Sample records for blood gas monitoring transcutaneous

  1. Clinical application and research progress of transcutaneous monitoring of noninvasive blood gas%经皮无创血气监测的临床应用及研究进展

    Institute of Scientific and Technical Information of China (English)

    张凤蕊; 平芬; 韩书芝; 李萍


    经皮无创血气监测具有无创、持续、动态监测等特点,弥补了传统血气分析的许多不足.经皮氧分压、经皮二氧化碳分压与PaO2、PaCO2有很好的相关性,故能够反映患者PaO2、PaCO2的即刻变化,广泛应用于临床的许多领域中,为许多疾病的早期发现,早期诊治及预后评估提供有价值的信息.%Transcutaneous monitoring of noninvasive blood gas is a noninvasive,continuous,and dynamic monitoring technique,makes up for many of the shortcomings of the traditional blood gas analysis.It had good correlation between transcutaneous oxygen tension,transcutaneous carbon dioxide tension and arterial oxygen tension (PaO2),arterial carbon dioxide tension (PaCO2),so it could reflect the immediate change of PaO2 and PaCO2 in patients.Transcutaneous monitoring of noninvasive blood gas has been already widely used in clinical sets and provided valuable informations for the early screening and diagnosis and prognosis assessment of many diseases.

  2. Continuous blood gas monitoring in femoral arteries (United States)

    Schlain, Les A.; Spar, Steven M.; Dellinger, Bart


    Continuous intra-arterial blood gas monitoring is a potentially valuable tool in the surgical and intensive care arenas. Patient oxygenation and acid base status can change rapidly and without warning. The ability to monitor pHa, PaCO2 and PaO2 in arterial blood will be a major medical advance for the anesthesiologist and intensivist. Intra-arterial blood gas sensors are typically placed in radial arteries. In certain patient populations accurate monitoring is not possible in radial arteries due to arterial environmental factors such as hypotension, vasoconstriction and atherosclerotic disease. These same factors can make radial cannulation difficult resulting in traumatic catheter insertion, thereby further compromising flow conditions. In situations where radial artery flow is expected to be compromised, selecting a large vessel for sensor placement is desirable. We report an initial feasibility study of our blood gas monitoring system using the femoral artery as the sensing site. Clinical results are presented as well as potential advantages and disadvantages associated with monitoring in the femoral artery.

  3. Clinical assessment of intraarterial blood gas monitor accuracy (United States)

    Aziz, Salim; Spiess, R.; Roby, Paul; Kenny, Margaret


    The accuracy of intraarterial blood gas monitoring (IABGM) devices is challenging to assess under routine clinical conditions. When comparing discrete measurements by blood gas analyzer (BGA) to IABGM values, it is important that the BGA determinations (reference method) be as accurate as possible. In vitro decay of gas tensions caused by delay in BGA analysis is particularly problematic for specimens with high arterial oxygen tension (PaO2) values. Clinical instability of blood gases in the acutely ill patient may cause disagreement between BGA and IABGM values because of IABGM response time lag, particularly in the measurement of arterial blood carbon dioxide tension (PaCO2). We recommend that clinical assessments of IABGM accuracy by comparison with BGA use multiple bedside BGA instruments, and that blood sampling only occur during periods when IABGM values appear stable.


    NARCIS (Netherlands)



    We have evaluated the possibility of monitoring the plasma lactate concentration in human volunteers during cycle ergometer exercise using subcutaneous and transcutaneous microdialysis. In transcutaneous microdialysis, the relative increase in dialysate lactate concentration exceeded that of plasma

  5. Transcutaneous measurement of volume blood flow (United States)

    Daigle, R. E.; Mcleod, F. D.; Miller, C. W.; Histand, M. B.; Wells, M. K.


    Blood flow velocity measurements, using Doppler velocimeter, are described. The ability to measure blood velocity using ultrasound is derived from the Doppler effect; the change in frequency which occurs when sound is reflected or transmitted from a moving target. When ultrasound of the appropriate frequency is transmitted through a moving blood stream, the blood cells act as point scatterers of ultrasonic energy. If this scattered ultrasonic energy is detected, it is found to be shifted in frequency according to the velocity of the blood cells, nu, the frequency of the incident sound, f sub o, the speed of sound in the medium, c, and the angle between the sound beam and the velocity vector, o. The relation describing this effect is known as the Doppler equation. Delta f = 2 f sub o x nu x cos alpha/c. The theoretical and experimental methods are evaluated.

  6. Use of transcutaneous oxygen and carbon dioxide tensions for assessing indices of gas exchange during exercise testing. (United States)

    Carter, R; Banham, S W


    The slow response characteristics of the combined transcutaneous electrode have been viewed as a major disadvantage when compared with other types of non-invasive assessment of gas exchange during exercise testing. We have previously shown that by using the highest recommended temperature of 45 degrees C to reduce response times, and combining this with an exercise protocol of gradual work load increments, that this allows changes in arterial blood gases to be closely followed by transcutaneous values. In the present study we have validated the use of a transcutaneous electrode for estimation of alveolar-arterial oxygen gradient (AaO2) and dead space to tidal volume ratio (V(D)/V(T)) during exercise, against values calculated from direct arterial blood gas analysis. One hundred measurements were made in 20 patients with various cardiopulmonary disorders who underwent exercise testing. Exercise testing was performed by bicycle ergometry with a specific protocol involving gradual work load increments at 2 min intervals. Transcutaneous gas tensions were measured by a heated combined O2 and CO2 electrode. Arterial blood was sampled at the midpoint of each stage of exercise and transcutaneous tensions noted at the end of each stage. The mean difference of the AaO2 gradient calculated from blood gas tensions obtained by the two methods was 0.14 kPa. The limits of agreement were -0.26 and 0.63 kPa. The same values for V(D)/V(T) calculated from gas tensions measured by the two methods were: mean difference 0001; limits of agreement -0.0242 and 0.0252. For both these parameters there was an even scatter around the mean value on Bland and Altman analysis. The findings of this study suggest that estimation of parameters of gas exchange using transcutaneous values during exercise testing is reliable, provided the electrode is heated to a slightly higher temperature than usual and the work load increments are gradual, allowing for the latency in the response time of the system

  7. Carbon dioxide monitoring during laparoscopic-assisted bariatric surgery in severely obese patients: transcutaneous versus end-tidal techniques. (United States)

    Dion, Joanna M; McKee, Chris; Tobias, Joseph D; Herz, Daniel; Sohner, Paul; Teich, Steven; Michalsky, Marc


    Various factors including severe obesity or increases in intra-abdominal pressure during laparoscopy can lead to inaccuracies in end-tidal carbon dioxide (PETCO2) monitoring. The current study prospectively compares ET and transcutaneous (TC) CO2 monitoring in severely obese adolescents and young adults during laparoscopic-assisted bariatric surgery. Carbon dioxide was measured with both ET and TC devices during insufflation and laparoscopic bariatric surgery. The differences between each measure (PETCO2 and TC-CO2) and the PaCO2 were compared using a non-paired t test, Fisher's exact test, and a Bland-Altman analysis. The study cohort included 25 adolescents with a mean body mass index of 50.2 kg/m2 undergoing laparoscopic bariatric surgery. There was no difference in the absolute difference between the TC-CO2 and PaCO2 (3.2±3.0 mmHg) and the absolute difference between the PETCO2 and PaCO2 (3.7±2.5 mmHg). The bias and precision were 0.3 and 4.3 mmHg for TC monitoring versus PaCO2 and 3.2 and 3.2 mmHg for ET monitoring versus PaCO2. In the young severely obese population both TC and PETCO2 monitoring can be used to effectively estimate PaCO2. The correlation of PaCO2 to TC-CO2 is good, and similar to the correlation of PaCO2 to PETCO2. In this population, both of these non-invasive measures of PaCO2 can be used to monitor ventilation and minimize arterial blood gas sampling.

  8. The influence of transcutaneous electrical neurostimulation (TENS) on human cerebral blood flow velocities

    NARCIS (Netherlands)

    ter Laan, Mark; van Dijk, J. Marc C.; Elting, Jan-Willem J.; Fidler, Vaclav; Staal, Michiel J.


    It has been shown that transcutaneous electrical neurostimulation (TENS) reduces sympathetic tone. Spinal cord stimulation (SCS) has proven qualities to improve coronary, peripheral, and cerebral blood circulation. Therefore, we postulate that TENS and SCS affect the autonomic nervous system in anal

  9. Transcutaneous monitoring of steroid-induced osteoporosis with Raman spectroscopy (United States)

    Maher, Jason R.; Inzana, Jason; Takahata, Masahiko; Awad, Hani A.; Berger, Andrew J.


    Although glucocorticoids are among the most frequently prescribed anti-inflammatory agents used in the treatment of rheumatoid arthritis, extended exposure to this steroid hormone is the leading cause of iatrogenic osteoporosis. Recently, Raman spectroscopy has been utilized to exploit biochemical differences between osteoporotic and normal bones in order to predict fracture risk. In this presentation, we report the results of ongoing research in our laboratory towards the clinical translation of this technique. We will discuss strategies for the transcutaneous acquisition of spectra from the tibiae of mice that are of sufficient quality to generate accurate predictions of fracture risk.

  10. Assessment of a continuous blood gas monitoring system in animals during circulatory stress

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    Renzulli Attilio


    Full Text Available Abstract Background The study was aimed to determine the measurement accuracy of The CDI™ blood parameter monitoring system 500 (Terumo Cardiovascular Systems Corporation, Ann Arbor MI in the real-time continuous measurement of arterial blood gases under different cardiocirculatory stress conditions Methods Inotropic stimulation (Dobutamine 2.5 and 5 μg/kg/min, vasoconstriction (Arginine-vasopressin 4, 8 and 16 IU/h, hemorrhage (-10%, -20%, -35%, and -50% of the theoretical volemia, and volume resuscitation were induced in ten swine (57.4 ± 10.7 Kg.Intermittent blood gas assessments were carried out using a routine gas analyzer at any experimental phase and compared with values obtained at the same time settings during continuous monitoring with CDI™ 500 system. The Bland-Altman analysis was employed. Results Bias and precision for pO2 were - 0.06 kPa and 0.22 kPa, respectively (r2 = 0.96; pCO2 - 0.02 kPa and 0.15 kPa, respectively; pH -0.001 and 0.01 units, respectively ( r2 = 0.96. The analysis showed very good agreement for SO2 (bias 0.04,precision 0.33, r2 = 0.95, Base excess (bias 0.04,precision 0.28, r2 = 0.98, HCO3 (bias 0.05,precision 0.62, r2 = 0.92,hemoglobin (bias 0.02,precision 0.23, r2 = 0.96 and K+ (bias 0.02, precision 0.27, r2 = 0.93. The sensor was reliable throughout the experiment during hemodynamic variations. Conclusions Continuous blood gas analysis with the CDI™ 500 system was reliable and it might represent a new useful tool to accurately and timely monitor gas exchange in critically ill patients. Nonetheless, our findings need to be confirmed by larger studies to prove its reliability in the clinical setting.

  11. Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration

    Institute of Scientific and Technical Information of China (English)

    Wenliang Chen(陈文亮); Rong Liu(刘蓉); Houxin Cui(崔厚欣); Kexin Xu(徐可欣); Lina Lü(吕丽娜)


    In this paper, the propagation characteristics of near-infrared (NIR) light in the palm tissue are analyzed,and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasive blood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectance spectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopy are designed. Based on this system, oral glucose tolerance tests are performed to measure the blood glucose concentrations of two young healthy volunteers. The partial least square calibration model is then constructed by all individual experimental data. The final result shows that correlation coefficients of the two experiments between the predicted blood glucose concentrations and the reference blood glucose concentrations are 0.9870 and 0.9854, respectively. The root mean square errors of prediction of full cross validation are 0.54 and 0.52 mmol/1, respectively.

  12. Transcutaneous oximetry monitoring in patients with type 2 diabetes mellitus and critical limb ischemia

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    O N Bondarenko


    Full Text Available Aims. To evaluate transcutaneous oximetry as a method for diagnostics and monitoring in patients with diabetes mellitus (DM and critical limb ischemia (CLI after percutaneous transluminal balloon angioplasty (PTBA.Materials and Methods. We enrolled 126 patients with DM and CLI for participation in this study (148 limbs in total. 22 patients underwent PTBA on both lower limbs, and 104 – on single limb. Transcutaneous oximetry and duplex ultrasonography of lower limb arteries was performed prior to PTBA with subsequent examinations on 5-7th days, 1st, 3rd and 6th month after intervention. Transcu- taneous oxygen tension (TcpO2 was measured by Radiometer (Copenhagen oximeter system. Duplex ultrasonography was performed on Voluson 730® Expert system (GE Medical Systems Kretztechnik GmbH&Co OHG, Austria.Results. Multiple factor analysis suggests that results of TcpO2 monitoring prior to and after PTBA are influenced by presence of ischemic heart disease, severe lower limb infections, serum creatinine, arterial hypertension and lower limb reperfusion edema. We observed a strong correlation of TcpO2 with the degree of anterior tibial artery and dorsal pedis artery occlusion.Conclusion. Transcutaneous oximetry allows evaluation of CLI severity and efficiency of PTBA in the majority oа patients with DM and CLI. Certain comorbidities impose limitations on this technique. Efficiency of endovascular intervention should be evaluated based on complex non-invasive examination, clinical data and signs of CLI.

  13. Modulation of cerebral blood flow with transcutaneous electrical neurostimulation (TENS) in patients with cerebral vasospasm after subarachnoid hemorrhage

    NARCIS (Netherlands)

    ter Laan, Mark; van Dijk, J.M.C.; Stewart, Roy; Staal, Michiel J; Elting, Jan-Willem J


    ObjectivesTranscutaneous electrical neurostimulation (TENS) and spinal cord stimulation have been shown to increase peripheral and cerebral blood flow. We postulate that certain pathological conditions attenuate cerebral autoregulation, which may result in a relative increase of the importance of ne

  14. Novel diode-based laser system for combined transcutaneous monitoring and computer-controlled intermittent treatment of jaundiced neonates (United States)

    Hamza, Mostafa; El-Ahl, Mohammad H. S.; Hamza, Ahmad M.


    The high efficacy of laser phototherapy combined with transcutaneous monitoring of serum bilirubin provides optimum safety for jaundiced infants from the risk of bilirubin encephalopathy. In this paper the authors introduce the design and operating principles of a new laser system that can provide simultaneous monitoring and treatment of several jaundiced babies at one time. The new system incorporates diode-based laser sources oscillating at selected wavelengths to achieve both transcutaneous differential absorption measurements of bilirubin concentration in addition to the computer controlled intermittent laser therapy through a network of optical fibers. The detailed description and operating characteristics of this system are presented.

  15. 经皮氧分压监测在骨科手术中的应用%Application of transcutaneous partial pressure of oxygen monitoring in orthopedics surgery

    Institute of Scientific and Technical Information of China (English)

    公茂伟; 米卫东; 傅强; 刘靖; 张宏


    目的 评价经皮氧分压(TcPO2)监测在临床麻醉中的应用价值.方法 对28例在全麻下实施骨科手术的患者进行持续TcPO2监测,分别在吸入氧浓度(FiO2)为21%、40%、70%与100%时进行动脉血气分析测定,并与动脉血氧分压(Pa02)进行对比,比较4组不同FiO2的经皮氧分压指数(TcPO2/PaO2).结果 在不同吸入氧浓度的条件下,TcPO2与PaO2之间均呈显著正相关,FiO2为21%时TcPO2与PaO2相关系数r=0.599(P<0.01),FiO2为40%时r=0.715(P<0.01),FiO2为70%时r=0.718(P<0.01),FiO2为100%时r=0.708(P<0.01).4组TePO2/PaO2/无显著性差异(P=0.063).结论 TcPO2/能够较准确地反映PaO2/的变化趋势,并且TcPO2/PaO2可有效地反映组织灌注,经皮氧分压监测技术在临床麻醉中应用具有可行性.%Objective To evaluate the application value of transcutaneous partial pressure of oxygen (TcPO2) monitoring in clinical anesthesia. Methods Twenty-eight patients who underwent general anesthesia and orthopedics surgery were studied. The inhaled oxygen concentrations (FiO2) were 21%, 40%, 70% and 100%, and the TcPO2 were measured with TC devices and arterial blood gas analysis were tested simultaneously. Measurements of TcPO2 were compared with arterial blood oxygen pressure(PaO2) in different inhaled oxygen concentrations respectively, and four groups of transcutaneous oxygen indexes (TcPO2/PaO2) were compared. Results Although inhaled oxygen concentrations were different, TcPO2 correlated positively with PaO2. When FiO2 was 21%, the correlation coefficients ( r )for TcPO2 and PaO2 was 0.599 (P< 0.01); while when FiO2 was 40%, 70% and 100%, the rwas 0.715 (P< 0.01), 0.718 (P< 0.01), and 0.708 respectively(P < 0.01). There was no significant difference in four groups in TcPO2/PaO2 (P = 0.063). Conclusions TcPO2 reflects the trend of PaO2 change more accurately and TcPO2/PaO2 can effectively reflect tissue perfusion. Transcutaneous partial pressure of oxygen monitoring in

  16. Effects of the transcutaneous electrode temperature on the accuracy of transcutaneous carbon dioxide tension

    DEFF Research Database (Denmark)

    Sørensen, Line C; Brage-Andersen, Lene; Greisen, Gorm


    The harmful effect of hypocapnia on the neonatal brain emphasizes the importance of monitoring arterial carbon dioxide tension (PaCO2). Transcutaneous monitoring of carbon dioxide (tcPCO2) reduces the need for arterial blood sampling. Drawbacks are high electrode temperature causing risks of skin...

  17. Flap monitoring by transcutaneous PO2 and PCO2: importance of transcutaneous PCO2 in determining follow-up treatment for compromised free flaps. (United States)

    Hashimoto, Ichiro; Nakanishi, Hideki; Takiwaki, Hirotsugu; Takase, Maki Toda; Yamano, Masahiro; Sedo, Hiromichi


    The authors conducted a two-part study to determine whether transcutaneous oxygen pressure (TcPO (2)) and transcutaneous carbon dioxide pressure (TcPCO (2)) can be used to monitor flap viability after transplantation. The first part was an animal study in which TcPO (2) and TcPCO (2) were measured in 10 epigastric island flaps subjected to arterial or venous ischemia. The second part was a clinical study in which both were measured in 27 free skin flaps. In the experimental study, TcPO (2) decreased to nearly 0 mmHg after 10 minutes of arterial and venous ischemia. TcPCO (2) increased to 100 mmHg after 60 minutes of either type of ischemia. In the clinical study, congestion was suspected in six flaps on the basis of clinical signs alone. Three congested flaps with TcPCO (2) more than 90 mmHg were selected for intervention. The remaining three congested flaps, with TcPCO (2) 80 mmHg or less, survived completely without further treatment. The TcPO (2) of all treated flaps and of the six flaps not requiring further treatment was 0 mmHg. Results of experimental study indicate that TcPO (2) is more sensitive than TcPCO (2) to flap ischemia. However, results of clinical study suggest that it is very hard to distinguish congested flaps from healthy flaps by TcPO (2) alone. The authors believe that a congested flap with a TcPCO (2) more than 90 mmHg requires further treatment.

  18. S35: a new parameter in blood gas analysis for monitoring the systemic oxygenation. (United States)

    Trouwborst, A; Tenbrinck, R; Van Woerkens, E C


    In the estimation of oxygen transport the term oxygen availability is used as the product of cardiac output and the arterial oxygen content (CaO2). Attempts can be made to modify the concept of oxygen availability by subtracting from the CaO2 the venous content at a critical PO2 as measured in mixed venous blood (Pv-O2), where oxygen diffusion into tissue becomes compromised and oxygen uptake (VO2) may decrease. The real arterial available oxygen content (CavlO2) can be calculated by estimating the saturation at the critical Pv-O2. For our concept S35 was chosen as such a dynamic baseline. Similar modification of oxygen extraction ratio (ERav) defined as VO2 divided by the real oxygen availability (O2av) should give, more than the classic ER, a realistic indices of oxygen availability in relation to oxygen consumption. It can be hypothesized that VO2 starts to decline when ERav is around 1.0. During isovolemic hemodilution VO2 started to drop when ERav reached 1.08 +/- 0.09. The S35 changed from 55.0 +/- 2.1% to 41.5 +/- 4.1%, correlated with changes in Pv-O2. A direct correlation was also found between the increase of the classic ER and the change in S35. We conclude that the S35, the CavlO2 and the ERav can be of value in monitoring the systemic oxygenation and that the concept also includes the effect of changes in oxyhemoglobin characteristics on oxygen delivery.

  19. Home monitoring of blood pressure


    McGrath, Barry P.


    Home blood pressure monitoring is the self-measurement of blood pressure by patients. In the diagnosis and management of high blood pressure it is complementary to 24-hour ambulatory blood pressure monitoring and clinic blood pressure measurements. Home monitoring can also help to identify white-coat and masked hypertension.

  20. Interference of heart and transcutaneous oxygen monitoring in the measurement of bioelectrical impedance analysis in preterm newborns

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    Viviane C. Comym

    Full Text Available Abstract Objective: To verify if the connection of electrodes for heart and transcutaneous oxygen monitoring interfere with the measurement of electrical bioimpedance in preterm newborns. Methods: This was a prospective, blinded, controlled, cross-sectional, crossover study that assessed and compared paired measures of resistance (R and reactance (Xc by BIA, obtained with and without monitoring wires attached to the preterm newborn. The measurements were performed in immediate sequence, after randomization to the presence or absence of electrodes. The sample size calculated was 114 measurements or tests with monitoring wires and 114 without monitoring wires, considering for a difference between the averages of 0.1 ohms, with an alpha error of 10% and beta error of 20%, with significance <0.05. Results: No differences were observed between the R (677.37 ± 196.07 vs. 677.46 ± 194.86 and Xc (31.15 ± 9.36 vs. 31.01 ± 9.56 values obtained with and without monitoring wires, respectively, with good correlation between them (R: 0.997 and Xc: 0.968. Conclusion: The presence of heart and/or transcutaneous oxygen monitoring wires connected to the preterm newborn did not affect the values of R or Xc measured by BIA, allowing them to be carried out in this population without risks.

  1. Effects of the transcutaneous electrode temperature on the accuracy of transcutaneous carbon dioxide tension

    DEFF Research Database (Denmark)

    Sørensen, Line C; Brage-Andersen, Lene; Greisen, Gorm


    The harmful effect of hypocapnia on the neonatal brain emphasizes the importance of monitoring arterial carbon dioxide tension (PaCO2). Transcutaneous monitoring of carbon dioxide (tcPCO2) reduces the need for arterial blood sampling. Drawbacks are high electrode temperature causing risks of skin...... burning. The aim was to determine the accuracy and precision of tcPCO2 at reduced electrode temperature....

  2. [Changes in the blood rheological properties in the transcutaneous irradiation of the ulnar vascular fascicle with a helium-neon laser]. (United States)

    Paleev, N R; Karandashov, V I; Voronina, M A; Fin'ko, I A


    An investigation of blood rheologic properties in 12 patients with acute pneumonia has been made by using low-energy He-Ne laser (LG-79-2) irradiation of vascular fascicle. 37 exposures have been performed, 40 min each. Immediate effects of He-Ne laser were studied comparing blood samples taken before and after the radiation. Results obtained have demonstrated transcutaneous blood irradiation causing prompt and pronounced effects on blood rheologic characteristics: reduced blood viscosity, improved both viscous-elastic properties and osmotic resistance of erythrocytes, activated platelet aggregation. These effects excluding the latter are rather positive for the human body. As for platelet aggregation, its activation following transcutaneous laser irradiation of blood might be expected to grow into a factor of risk provoking pathologic thrombogenesis in venous congestion, hypercoagulation and vascular wall injury.

  3. A rate-based transcutaneous CO2 sensor for noninvasive respiration monitoring


    Chatterjee, M; Ge, X; Kostov, Y; Luu, P; Tolosa, L; Woo, H.; Viscardi, R; Falk, S; R. Potts; G Rao


    The pain and risk of infection associated with invasive blood sampling for blood gas measurements necessitate the search for reliable noninvasive techniques. In this work we developed a novel rate-based noninvasive method for a safe and fast assessment of respiratory status. A small sampler was built to collect the gases diffusing out of the skin. It was connected to a CO2 sensor through gas-impermeable tubing. During a measurement, the CO2 initially present in the sampler was first removed b...

  4. Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost. (United States)

    Melillo, Elio; Grigoratos, Chrysanthos; Sanctis, Francesco De; Spontoni, Paolo; Nuti, Marco; Dell'Omodarme, Matteo; Ferrari, Mauro; Balbarini, Alberto


    We evaluated the effectiveness of intravenous iloprost (IVI) in outpatients with thromboangiitis obliterans (TAO) and lower limb noninvasive transcutaneous monitoring (TCM) at follow-up (FU). Ten consecutive patients with TAO underwent IVI therapy. Transcutaneous oxygen (TcPo 2) and carbon dioxide (TcPco 2) determination and laser Doppler flowmetry (LDF) were performed before and after IVI at 3, 6, and 12 months of FU. Clinical response was positive in 7 patients, whereas 3 nonresponders underwent a second IVI cycle with 1 showing a late positive clinical response. After 12 months of FU, all patients were alive without amputations. Supine and dependent TcP2 levels significantly improved (P < .005). Hallux LDF values showed significant change with the maximal hyperemic test at 44°C (P < .005). Forefoot maximal hyperemic test at 44°C LDF (P < .005) and improved venous arterial reflex (P < .05) showed statistically significant time evolution. We demonstrated some degree of IVI effectiveness and evaluated TCM in patients with TAO.


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    R. Fuentes


    Full Text Available In this work we present a blood pressure monitor which measures both the high blood pressure (systolic pressure,and the low blood pressure (diastolic pressure. It is a semiautomatic meter because the inflation of the occlusivecuff is carried out in a manual way. The transducer used is a piezoresistive silicon pressure sensor integrated onchip which provides a proportional voltage to the input pressure, with a measurement range from 0 to 50 kPa (0–7.3 PSI. The oscillometric method is employed, which consists on detecting the oscillometric signal on brachialartery, being processed at each pressure step, when the cuff is gradually deflated. Signal sampling is carried out ata rate determined by the heart rate.In order to program the digital electronics of the circuit we used Altera tools, with the compiler MAX-PLUS II, andthe device selected to implement the design was an EPM7128SLC84-15 CPLD (Complex Programmable LogicDevice

  6. A novel system for transcutaneous application of carbon dioxide causing an "artificial Bohr effect" in the human body.

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    Yoshitada Sakai

    Full Text Available BACKGROUND: Carbon dioxide (CO(2 therapy refers to the transcutaneous administration of CO(2 for therapeutic purposes. This effect has been explained by an increase in the pressure of O(2 in tissues known as the Bohr effect. However, there have been no reports investigating the oxygen dissociation of haemoglobin (Hb during transcutaneous application of CO(2in vivo. In this study, we investigate whether the Bohr effect is caused by transcutaneous application of CO2 in human living body. METHODS: We used a novel system for transcutaneous application of CO(2 using pure CO(2 gas, hydrogel, and a plastic adaptor. The validity of the CO(2 hydrogel was confirmed in vitro using a measuring device for transcutaneous CO(2 absorption using rat skin. Next, we measured the pH change in the human triceps surae muscle during transcutaneous application of CO(2 using phosphorus-31 magnetic resonance spectroscopy ((31P-MRS in vivo. In addition, oxy- and deoxy-Hb concentrations were measured with near-infrared spectroscopy in the human arm with occulted blood flow to investigate O2 dissociation from Hb caused by transcutaneous application of CO(2. RESULTS: The rat skin experiment showed that CO(2 hydrogel enhanced CO(2 gas permeation through the rat skin. The intracellular pH of the triceps surae muscle decreased significantly 10 min. after transcutaneous application of CO(2. The NIRS data show the oxy-Hb concentration decreased significantly 4 min. after CO(2 application, and deoxy-Hb concentration increased significantly 2 min. after CO(2 application in the CO(2-applied group compared to the control group. Oxy-Hb concentration significantly decreased while deoxy-Hb concentration significantly increased after transcutaneous CO(2 application. CONCLUSIONS: Our novel transcutaneous CO(2 application facilitated an O(2 dissociation from Hb in the human body, thus providing evidence of the Bohr effect in vivo.

  7. Electrical characteristic of the titanium mesh electrode for transcutaneous intrabody communication to monitor implantable artificial organs. (United States)

    Okamoto, Eiji; Kikuchi, Sakiko; Mitamura, Yoshinori


    We have developed a tissue-inducing electrode using titanium mesh to obtain mechanically and electrically stable contact with the tissue for a new transcutaneous communication system using the human body as a conductive medium. In this study, we investigated the electrical properties of the titanium mesh electrode by measuring electrode-tissue interface resistance in vivo. The titanium mesh electrode (Hi-Lex Co., Zellez, Hyogo, Japan) consisted of titanium fibers (diameter of 50 μm), and it has an average pore size of 200 μm and 87 % porosity. The titanium mesh electrode has a diameter of 5 mm and thickness of 1.5 mm. Three titanium mesh electrodes were implanted separately into the dorsal region of the rat. We measured the electrode-electrode impedance using an LCR meter for 12 weeks, and we calculated the tissue resistivity and electrode-tissue interface resistance. The electrode-tissue interface resistance of the titanium mesh electrode decreased slightly until the third POD and then continuously increased to 75 Ω. The electrode-tissue interface resistance of the titanium mesh electrode is stable and it has lower electrode-tissue interface resistance than that of a titanium disk electrode. The extracted titanium mesh electrode after 12 weeks implantation was fixed in 10 % buffered formalin solution and stained with hematoxylin-eosin. Light microscopic observation showed that the titanium mesh electrode was filled with connective tissue, inflammatory cells and fibroblasts with some capillaries in the pores of the titanium mesh. The results indicate that the titanium mesh electrode is a promising electrode for the new transcutaneous communication system.

  8. Monitoring Blood Sugar: The Importance of Checking Blood Sugar Levels (United States)

    ... Your 1- to 2-Year-Old Monitoring Blood Sugar KidsHealth > For Parents > Monitoring Blood Sugar Print A ... Tests Record Keeping The Importance of Checking Blood Sugar Levels Besides helping to keep blood sugar levels ( ...

  9. Monitoring Blood Sugar: The Importance of Checking Blood Sugar Levels (United States)

    ... Feeding Your 1- to 2-Year-Old Monitoring Blood Sugar KidsHealth > For Parents > Monitoring Blood Sugar A ... Other Tests Record Keeping The Importance of Checking Blood Sugar Levels Besides helping to keep blood sugar ...

  10. Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models

    Directory of Open Access Journals (Sweden)

    Michael D. Poscente


    Full Text Available Transcutaneous intraluminal impedance measurement (TIIM is a new method to cutaneously measure gastric contractions by assessing the attenuation dynamics of a small oscillating voltage emitted by a battery-powered ingestible capsule retained in the stomach. In the present study, we investigated whether TIIM can reliably assess gastric motility in acute canine models. Methods. Eight mongrel dogs were randomly divided into 2 groups: half received an active TIIM pill and half received an identically sized sham capsule. After 24-hour fasting and transoral administration of the pill (active or sham, two force transducers (FT were sutured onto the antral serosa at laparotomy. After closure, three standard cutaneous electrodes were placed on the abdomen, registering the transluminally emitted voltage. Thirty-minute baseline recordings were followed by pharmacological induction of gastric contractions using neostigmine IV and another 30-minute recording. Normalized one-minute baseline and post-neostigmine gastric motility indices (GMIs were calculated and Pearson correlation coefficients (PCCs between cutaneous and FT GMIs were obtained. Statistically significant GMI PCCs were seen in both baseline and post-neostigmine states. There were no significant GMI PCCs in the sham capsule test. Further chronic animal studies of this novel long-term gastric motility measurement technique are needed before testing it on humans.

  11. Noninvasive monitoring of PaCO2 during one-lung ventilation and minimal access surgery in adults: End-tidal versus transcutaneous techniques


    Cox, Paul; Tobias, Joseph D.


    Background: Previous studies have suggested that end-tidal CO2 (ET-CO2) may be inaccurate during one-lung ventilation (OLV). This study was performed to compare the accuracy of the noninvasive monitoring of PCO2 using transcutaneous CO2 (TC-CO2) with ET-CO2 in patients undergoing video-assisted thoracoscopic surgery (VATS) during OLV. Materials and Methods: In adult patients undergoing thoracoscopic surgical procedures, PCO2 was simultaneously measured with TC-CO2 and ET-CO2 devices and compa...

  12. Rugged and breathable forms of stretchable electronics with adherent composite substrates for transcutaneous monitoring. (United States)

    Jang, Kyung-In; Han, Sang Youn; Xu, Sheng; Mathewson, Kyle E; Zhang, Yihui; Jeong, Jae-Woong; Kim, Gwang-Tae; Webb, R Chad; Lee, Jung Woo; Dawidczyk, Thomas J; Kim, Rak Hwan; Song, Young Min; Yeo, Woon-Hong; Kim, Stanley; Cheng, Huanyu; Rhee, Sang Il; Chung, Jeahoon; Kim, Byunggik; Chung, Ha Uk; Lee, Dongjun; Yang, Yiyuan; Cho, Moongee; Gaspar, John G; Carbonari, Ronald; Fabiani, Monica; Gratton, Gabriele; Huang, Yonggang; Rogers, John A


    Research in stretchable electronics involves fundamental scientific topics relevant to applications with importance in human healthcare. Despite significant progress in active components, routes to mechanically robust construction are lacking. Here, we introduce materials and composite designs for thin, breathable, soft electronics that can adhere strongly to the skin, with the ability to be applied and removed hundreds of times without damaging the devices or the skin, even in regions with substantial topography and coverage of hair. The approach combines thin, ultralow modulus, cellular silicone materials with elastic, strain-limiting fabrics, to yield a compliant but rugged platform for stretchable electronics. Theoretical and experimental studies highlight the mechanics of adhesion and elastic deformation. Demonstrations include cutaneous optical, electrical and radio frequency sensors for measuring hydration state, electrophysiological activity, pulse and cerebral oximetry. Multipoint monitoring of a subject in an advanced driving simulator provides a practical example.

  13. Gas House Autonomous System Monitoring (United States)

    Miller, Luke; Edsall, Ashley


    Gas House Autonomous System Monitoring (GHASM) will employ Integrated System Health Monitoring (ISHM) of cryogenic fluids in the High Pressure Gas Facility at Stennis Space Center. The preliminary focus of development incorporates the passive monitoring and eventual commanding of the Nitrogen System. ISHM offers generic system awareness, adept at using concepts rather than specific error cases. As an enabler for autonomy, ISHM provides capabilities inclusive of anomaly detection, diagnosis, and abnormality prediction. Advancing ISHM and Autonomous Operation functional capabilities enhances quality of data, optimizes safety, improves cost effectiveness, and has direct benefits to a wide spectrum of aerospace applications.

  14. [Intraoperative monitoring in artificial respiration of premature and newborn infants. I. Monitoring of respiratory parameters and alveolar ventilation]. (United States)

    Lenz, G; Heipertz, W; Leidig, E; Madee, S


    Monitoring of ventilation serves to ensure adequate alveolar ventilation and arterial oxygenation, and to avoid pulmonary damage due to mechanical ventilation. Basic clinical monitoring, i.e., inspection, auscultation (including precordial or oesophageal stethoscope) and monitoring of heart rate and blood pressure, is mandatory. Mechanical ventilation is monitored by ventilation pressures (peak pressure, plateau pressure and endexpiratory pressure), ventilation volumes (measured at the in/expiratory valve of the respirator and by hot-wire anemometry at the tube connector), ventilation rate, and inspiratory oxygen concentration (FiO2). Alveolar ventilation should be continuously and indirectly recorded by capnometry (pECO2) and by measurement of transcutaneous pCO2 (tcpCO2), whereas oxygenation is determined via measurement of transcutaneous pO2 (tcpO2). Invasive monitoring of gas exchange is essential in prolonged or intrathoracic interventions as well as in neonates with cardiopulmonary problems. paCO2 may be estimated by capillary or venous blood gas analysis; arterial blood gas analysis is required for exact determination of paCO2 as well as arteriocutaneous pCO2 (atcDCO2) and arterio-end-expiratory (aEDCO2) gradients.

  15. Blood monitoring of perfluorocarbon compounds (F-tert-butylcyclohexane, perfluoromethyldecalin and perfluorodecalin) by headspace-gas chromatography-tandem mass spectrometry. (United States)

    Giuliani, N; Saugy, M; Augsburger, M; Varlet, V


    A headspace-gas chromatography-tandem mass spectrometry (HS-GC-MS/MS) method for the trace measurement of perfluorocarbon compounds (PFCs) in blood was developed. Due to oxygen carrying capabilities of PFCs, application to doping and sports misuse is speculated. This study was therefore extended to perform validation methods for F-tert-butylcyclohexane (Oxycyte(®)), perfluoro(methyldecalin) (PFMD) and perfluorodecalin (PFD). The limit of detection of these compounds was established and found to be 1.2 µg/mL blood for F-tert-butylcyclohexane, 4.9 µg/mL blood for PFMD and 9.6 µg/mL blood for PFD. The limit of quantification was assumed to be 12 µg/mL blood (F-tert-butylcyclohexane), 48 µg/mL blood (PFMD) and 96 µg/mL blood (PFD). HS-GC-MS/MS technique allows detection from 1000 to 10,000 times lower than the estimated required dose to ensure a biological effect for the investigated PFCs. Thus, this technique could be used to identify a PFC misuse several hours, maybe days, after the injection or the sporting event. Clinical trials with those compounds are still required to evaluate the validation parameters with the calculated estimations.

  16. A Novel Infrared Gas Monitor (United States)

    Wang, Yingding; Zhong, Hongjie


    In the paper a novel non-dispersive infrared(IR) gas monitor is described.It is based on the principle that certain gases absorb IR radiation at specific(and often unique) wavelengths.Conventional devices typically include several primary components:a broadband source, usually an incandescent filament,a rotating chopper shutter,a narrow-band filter,a sample tube and a detector. We have developed a number of IR light emitting diodes(LED) having narrow optical bandwidths and which can be intensity modulated by electrical means,for example InAsSbP(4.2 micron)LED.The IR LED can thus replace the thermal source,narrow-band filter and chopper assembly of the conventional IR gas monitor,yielding a solid state,low- powered,compact and almost maintenance-free instrument with high sensitivity and stability and which free of the effects of mechanical vibration too. The detector used in the IR gas monitor is the solid-state detector,such as PbS,PbSe, InSb,HgCdTe,TGS,LT and PZT detector etc. The different configuration of the IR gas monitor is designed.For example,two-path version for measuring methane concentration by monitoring the 3.31 micron absorption band,it can eliminate the interference effects,such as to compensate for LED intensity changes caused by power and temperature variations,and for signal fluctuations due to changes in detector bias. we also have designed portable single-beam version without the sample tube.Its most primary advantage is very cheap(about cost USD 30 ).It measures carbon dioxide concentration by monitoring the 4.25 micron absorption band.Thought its precisions is low,it is used to control carbon dioxide concentration in the air in the green houses and plastic houses(there are about twenty millon one in the China).Because more carbon dioxide will increase the quanity of vegetable and flower production to a greatextent. It also is used in medical,sanitary and antiepidemic applications,such as hospital, store,hotel,cabin and ballroom etc. Key words

  17. Changes in EEG, systemic circulation and blood gas parameters following two or six aliquots of porcine surfactant. (United States)

    Lundstrøm, K E; Greisen, G


    Surfactant instillation often causes transient EEG suppression, the cause remaining unknown. To compare the timing of the EEG changes with the timing of the changes in blood gases and systemic circulation we compared two administration modes: 20 preterm infants were randomly assigned to receive the initial dose of surfactant divided into two or six aliquots. Heart rate, blood pressure and transcutaneous blood gases were measured continuously, while left ventricular output was estimated intermittently. No difference in blood gas response was found between the groups, whereas the circulatory changes occurred more gradually with six aliquots. EEG suppression was similar in the two groups and not related to the circulatory or the respiratory changes. Left ventricular output increased in all patients following surfactant instillation. We conclude that the EEG suppression is not directly related to alterations in blood gases or systemic circulation.

  18. Transcutaneous oximetry but not arterial toe blood pressure or ankle-brachial index is related to macular thickness in patients with chronic diabetic foot ulcers

    Directory of Open Access Journals (Sweden)

    Per Katzman


    Full Text Available Objectives: Diabetes related vascular complications of the lower extremity could be classified as micro- and macrovascular. Ankle-brachial index (ABI and toe blood pressure (TBP measurements evaluate macro-circulation, whereas transcutaneous oximetry (TcPO2 is considered to be a composite measure of vascular function, thereby also reflecting microcirculation. Microvascular disease in the eye involves abnormal capillary permeability and possibly thereby increased macular thickness. The aim of the present clinical study was to evaluate if microvascular disease in the eye was related to measures of foot ischemia in patients with diabetes mellitus. Methods: Twenty consecutive patients with diabetes and chronic full-thickness foot ulcers were included. Peripheral ischemia was diagnosed using TcPO2, TBP and ABI. Macular thickness was measured with optical coherence tomography technique. Results: Based on TcPO2, TBP and ABI measurements 14, 13 and 13 patients, respectively, were classified as ischemic. Patients with ischemic TcPO2 levels at the dorsum of the foot had significantly higher macular thicknesses. This was not the case in patients with ischemic TBP or ABI levels. Conclusion: TcPO2, unlike TBP and ABI, seems to be a clinically relevant measure of peripheral microvascular disease in patients with diabetes mellitus and may, if low, indicate an increased risk of macular edema. [J Exp Integr Med 2013; 3(2.000: 81-85

  19. Blood monitoring systems and methods thereof (United States)

    Mir, Jose (Inventor); Zander, Dennis (Inventor)


    A blood monitoring system is capable of monitoring the blood of a subject in vivo. The blood monitoring system comprises: 1) an array of movable microneedle micromachined within associated wells; 2) array of motion actuators able to move each needle in and out of their associated wells; 3) array of microvalves associated with each microneedle able to control the flow of air around the microneedle; 4) an array of chemical sensors inserted into patient by movable microneedles; 5) an array of inductors able to measure chemical concentration in the vicinity of inserted chemical sensors; 6) conducting vias that provide timed actuating signal signals from a control system to each motion actuator; 7) conducting vias that transmit signal produced by array of chemical sensors to the control system for processing, although the blood monitoring system can comprise other numbers and types of elements in other configurations.

  20. 脐血血气分析与胎儿Apgar评分监测缺氧的相关性研究%Study on correlation between umbilical cord blood gas analysis and Apgar scores in monitoring fetal hypoxia

    Institute of Scientific and Technical Information of China (English)



    Objective To study the correlation of umbilical cord blood gas analysis and Apgar scores in monitoring fetal hypoxia.Methods 180 cases of bom from March 2011 to March 2012 in our hospital,with the legislation collected cord blood samples for blood gas analysis,and two groups according to the results of fetal Apgar scores,were divided into experimental and control groups.The 90 cases of experimental group had fetal Apgar score ≤7 points,the 90 cases of control group had fetal Apgar score ≥8 points.combining with cord blood research blood gas analysis and fetal Apgar scores,we monitored the two groups of children with hypoxia and statistical analysis.Reaults The experimental group's fetal Apgar score ≤7 Pa02,HC03-,pH values were significantly lower than those of the control group (P<0.05),fetal PaC02 values of the experimental group,BE negative values were significantly higher than those in the control group (P<0.05).Concluaions Umbilical cord blood gas analysis for monitoring fetal Apgrscores neonatal hypoxia.can improve the neonatal diagnostic accuracy,and improve perinatal survival the control group (P<0.05).Conclusion umbilical cord blood gas analysis to monitor fetal Apgar scores neonatal hypoxia can improve the the neonatal diagnostic accuracy,and improve perinatal survival.%目的 研究脐血血气分析与胎儿Apgar评分监测缺氧的相关性.方法 选择2011年3月至2012年3月我院180例新生儿出生后,立采集脐血血样进行血气分析,并根据胎儿Apgar评分结果,分为实验组和对照组两组.实验组90例胎儿Apgar评分≤7分,对照组90例胎儿Apgar评分≥8分,结合研究脐血血气分析与胎儿Apgar评分情况,监测两组患儿缺氧情况,并进行统计分析.结果 Apgar评分≤7分的实验组胎儿的PaO2、HCO3-、pH值均明显低于Apgar评分≥8分的对照组胎儿(P<0.05),实验组胎儿的PaCO2值、BE负值均明显高于对照组(P<0.05).结论 脐血血气分析与胎

  1. Embedded programmable blood pressure monitoring system (United States)

    Hasan, Md. Mahmud-Ul; Islam, Md. Kafiul; Shawon, Mehedi Azad; Nowrin, Tasnuva Faruk


    A more efficient newer algorithm of detecting systolic and diastolic pressure of human body along with a complete package of an effective user-friendly embedded programmable blood pressure monitoring system has been proposed in this paper to reduce the overall workload of medical personals as well as to monitor patient's condition more conveniently and accurately. Available devices for measuring blood pressure have some problems and limitations in case of both analog and digital devices. The sphygmomanometer, being analog device, is still being used widely because of its reliability and accuracy over digital ones. But it requires a skilled person to measure the blood pressure and obviously not being automated as well as time consuming. Our proposed system being a microcontroller based embedded system has the advantages of the available digital blood pressure machines along with a much improved form and has higher accuracy at the same time. This system can also be interfaced with computer through serial port/USB to publish the measured blood pressure data on the LAN or internet. The device can be programmed to determine the patient's blood pressure after each certain interval of time in a graphical form. To sense the pressure of human body, a pressure to voltage transducer is used along with a cuff in our system. During the blood pressure measurement cycle, the output voltage of the transducer is taken by the built-in ADC of microcontroller after an amplifier stage. The recorded data are then processed and analyzed using the effective software routine to determine the blood pressure of the person under test. Our proposed system is thus expected to certainly enhance the existing blood pressure monitoring system by providing accuracy, time efficiency, user-friendliness and at last but not the least the 'better way of monitoring patient's blood pressure under critical care' all together at the same time.

  2. Coronary blood flow dynamics during transcutaneous electrical nerve stimulation for stable angina pectoris associated with severe narrowing of one major coronary artery

    NARCIS (Netherlands)

    Jessurun, GAJ; Tio, RA; De Jongste, MJL; Hautvast, RWM; Den Heijer, P; Crijns, HJGM


    To study the effect of transcutaneous electrical nerve stimulation (TENS) on coronary vasomotion, patients with New York Heart Association class III angina pectoris and significant single-vessel left coronary artery disease and who were also scheduled for elective percutaneous transluminal coronary

  3. Monitoring gas quality green gas feeding in; Monitoring gaskwaliteit groengasinvoeding

    Energy Technology Data Exchange (ETDEWEB)

    Holstein, J. [DNV KEMA Energy and Sustainability, Arnhem (Netherlands); Polman, E. [Kiwa Technology, Apeldoorn (Netherlands)


    Due to the growing number of green gas facilities in the Netherlands more practical knowledge is collected about the production and injection of green gas. Also there was the need to gather data about more practical experiences and knowledge about the gas quality, the performance of gas cleaning and gas treatment systems, as well the integration of green gas in the gas infrastructure. In addition to this, there is a need to get insight in the safety aspects of green gas injection. In order to comply this demand, DNV KEMA en Kiwa Technology measured the quality parameters continuously between June 2012 en January 2013 (three weeks) and discontinuously (gas samples) of green gas at eight production facilities. The measurements have been performed at designated places and are independent from the measurements of the biomethane producer. In order to be sure that the results of DNV KEMA and Kiwa are comparable, a combined measurement program was executed. It results in uniformity for all the measured values: the differences are within the uncertainty level for each component. During the measurement period of three weeks, the gas quality parameters were compared to specifications, written down in the national regulations for the transport and the distribution grid respectively [Dutch] Door het groeiend aantal groengasinvoedingen in Nederland wordt steeds meer praktijkkennis verzameld. Er dient meer praktijkkennis te worden verzameld over de chemische gaskwaliteit, prestaties van de gasreiniging- en gasopwaardering en de wijze van inpassing in de bestaande infrastructuur. Daarnaast is het wenselijk om inzicht te verkrijgen in de veiligheid van groengasinvoeding. Daarop is de groengaskwaliteit op acht locaties over een periode van drie weken continu en discontinu gemeten tussen juni 2012 en januari 2013. De metingen zijn uitgevoerd op een aangewezen plaats door de netbeheerder en staan los van de metingen van de invoeders zelf. Voor het waarborgen van de uniformiteit van

  4. Skin perfusion pressure measured by isotope washout in legs with arterial occlusive disease. Evaluation of different tracers, comparison to segmental systolic pressure, angiography and transcutaneous oxygen tension and variations during changes in systemic blood pressure

    DEFF Research Database (Denmark)

    Holstein, P; Trap-Jensen, J; Bagger, H


    The skin perfusion pressure (SPP) measured as the isotope washout cessation external pressure is valuable in selection of major amputation level. Five methodological investigations important to clinical use were carried out: (1) In five normal legs and 10 legs with arterial occlusive disease (AOD...... in legs with arterial occlusions at two levels or more; (4) In 47 legs with AOD, the SPP on the calf or on the thigh was compared with transcutaneously measured pO2. The two different methods correlated statistically significant, but the scatter was great; (5) During induced variations in systemic blood...... pressure in seven patients (12 legs with AOD), the segmental SPP and the segmental systolic blood pressure were found on average to vary in proportion with intra-arterial mean and systolic pressure respectively; however, this proportional relationship was not valid for the individual leg. It is concluded...

  5. Ambulatory Blood Pressure Monitoring in Clinical Practice: A Review


    Turner, J. Rick; Viera, Anthony J.; Shimbo, Daichi


    Ambulatory blood pressure monitoring offers the ability to collect blood pressure readings several times an hour across a 24-hour period. Ambulatory blood pressure monitoring facilitates the identification of white-coat hypertension, the phenomenon whereby certain individuals who are not on antihypertensive medication show elevated blood pressure in a clinical setting but show non-elevated blood pressure averages when assessed by ambulatory blood pressure monitoring. Additionally, readings ca...

  6. Surgical staple as a transcutaneous transducer for ECG electrodes in burnt skin: safe surgical monitoring in major burns. (United States)

    Sofos, Stratos S; Tehrani, Hamid; Shokrollahi, Kayvan; James, M I


    It is often difficult to apply traditional ECG electrodes on patients with extensive burns due to a large operative site, compromise of sterility, the fact that traditional placement would be within the operative site or because stick-on pads cannot stick due to prep solution, bleeding and other factors. We present an effective solution based on our experience, of using a common staple or "clip" where the ECG electrode is attached. We can see the patient in the prone position with the back having been debrided and grafted. This technical improvisation gives clinicians the ability to monitor safely and accurately the patients' physiological parameters.

  7. Ambulatory Blood Pressure Monitoring in the Elderly


    Juan Diego Mediavilla García; Fernando Jaén Águila; Celia Fernández Torres; Blas Gil Extremera; Juan Jiménez Alonso


    The incidence of hypertension is high in the elderly and is present in 2/3 of the patients older than 65 years. Prevalence can reach 90% in patients older than 80 years. The presence of isolated systolic hypertension (ISH) is characteristic of this population. However, the prevalence of hypertension by ambulatory blood pressure monitoring (ABPM) is not well known. In this study, we analyzed the special characteristics of hypertension in this population, giving special emphasis on ABPM readings.

  8. Beat-to-Beat Blood Pressure Monitor (United States)

    Lee, Yong Jin


    This device provides non-invasive beat-to-beat blood pressure measurements and can be worn over the upper arm for prolonged durations. Phase and waveform analyses are performed on filtered proximal and distal photoplethysmographic (PPG) waveforms obtained from the brachial artery. The phase analysis is used primarily for the computation of the mean arterial pressure, while the waveform analysis is used primarily to obtain the pulse pressure. Real-time compliance estimate is used to refine both the mean arterial and pulse pressures to provide the beat-to-beat blood pressure measurement. This wearable physiological monitor can be used to continuously observe the beat-to-beat blood pressure (B3P). It can be used to monitor the effect of prolonged exposures to reduced gravitational environments and the effectiveness of various countermeasures. A number of researchers have used pulse wave velocity (PWV) of blood in the arteries to infer the beat-to-beat blood pressure. There has been documentation of relative success, but a device that is able to provide the required accuracy and repeatability has not yet been developed. It has been demonstrated that an accurate and repeatable blood pressure measurement can be obtained by measuring the phase change (e.g., phase velocity), amplitude change, and distortion of the PPG waveforms along the brachial artery. The approach is based on comparing the full PPG waveform between two points along the artery rather than measuring the time-of-flight. Minimizing the measurement separation and confining the measurement area to a single, well-defined artery allows the waveform to retain the general shape between the two measurement points. This allows signal processing of waveforms to determine the phase and amplitude changes.

  9. Transcutaneous oxygen tension in imminent foot gangrene

    DEFF Research Database (Denmark)

    Tønnesen, K H


    with moderate obstruction, the oxygen tension reached zero at a toe systolic blood pressure of 5--10 mmHg (tilt toe up) and reached arterial oxygen tension at about 50 to 70 mmHg (tilt toe down). In legs withsevere arterial obstruction and ischaemic rest pain, oxygen tension rose from zero not before systolic......Transcutaneous oxygen tension at 44 degree C and maximal isotope clearance (90m Tc-pretechnetate + histramine) just proximal to the 1st toe and systolic toe blood pressure (strain gauge) were studied on a tilt table in patients with various degrees of obstructive arteriosclerotic disease. In legs...

  10. Monitoring and humidification during tracheal gas insufflation. (United States)

    Delgado, E; Hoffman, L A; Tasota, F J; Pinsky, M R


    In order to use tracheal gas insufflation (TGI) in a safe and effective manner, it is important to understand potential interactions between TGI and the mechanical ventilator that may impact upon gas delivery and carbon dioxide (CO2) elimination. Furthermore, potentially serious complications secondary to insufflation of cool, dry gas directly into the airway and the possibility of tube occlusion must be considered during use of this adjunct modality to mechanical ventilation. Regardless of the delivery modality (continuous TGI, expiratory TGI, reverse TGI, or bidirectional TGI), conventional respiratory monitoring is required. However, TGI with mechanical ventilation can alter tidal volume and peak inspiratory pressure and can lead to the development of intrinsic positive end-expiratory pressure. Therefore, depending on the gas delivery technique used, it is important to carefully monitor these ventilatory parameters for TGI-induced changes and understand the potential need for adjustments to ventilator settings to facilitate therapy and avoid problems. Optimally, gas insufflated by the TGI catheter should be conditioned by addition of heat and humidity to prevent mucus plug formation and potential damage to the tracheal mucosa. Finally, patients must be closely monitored for increases in peak inspiratory pressure from obstruction of the tracheal tube and should have the TGI catheter removed and inspected every 8-12 hours to assess for plugs.

  11. Prediction of arterial blood gas values from arterialized earlobe blood gas values in patients treated with mechanical ventilation

    Directory of Open Access Journals (Sweden)

    Honarmand Azim


    earlobe blood gas can accurately predict the ABG values of pH, PCO 2 , BE, and HCO 3 - for patients who do not require regular continuous blood pressure measurements and close monitoring of arterial PO 2 measurements.

  12. A xenon gas purity monitor for EXO

    CERN Document Server

    Dobi, A; Herrin, S; Odian, A; Prescott, C Y; Rowson, P C; Ackerman, N; Aharmin, B; Auger, M; Barbeau, P S; Barry, K; Benitez-Medina, C; Breidenbach, M; Cook, S; Counts, I; Daniels, T; DeVoe, R; Dolinski, M J; Donato, K; Fairbank, W; Farine, J; Giroux, G; Gornea, R; Graham, K; Gratta, G; Green, M; Hagemann, C; Hall, K; Hallman, D; Hargrove, C; Karelin, A; Kaufman, L J; Kuchenkov, A; Kumar, K; Lacey, J; Leonard, D S; LePort, F; Mackay, D; MacLellan, R; Mong, B; Diez, M Montero; Muller, A R; Neilson, R; Niner, E; O'Sullivan, K; Piepke, A; Pocar, A; Pushkin, K; Rollin, E; Sinclair, D; Slutsky, S; Stekhanov, V; Twelker, K; Voskanian, N; Vuilleumier, J -L; Wichoski, U; Wodin, J; Yang, L; Yen, Y -R


    We discuss the design, operation, and calibration of two versions of a xenon gas purity monitor (GPM) developed for the EXO double beta decay program. The devices are sensitive to concentrations of oxygen well below 1 ppb at an ambient gas pressure of one atmosphere or more. The theory of operation of the GPM is discussed along with the interactions of oxygen and other impurities with the GPM's tungsten filament. Lab tests and experiences in commissioning the EXO-200 double beta decay experiment are described. These devices can also be used on other noble gases.

  13. Blood gas partition coefficient and pulmonary extraction ratio for propofol in goats and pigs. (United States)

    Grossherr, M; Hengstenberg, A; Dibbelt, L; Igl, B-W; Noel, R; Knesebeck, A v d; Schmucker, P; Gehring, H


    The interpretation of continuously measured propofol concentration in respiratory gas demands knowledge about the blood gas partition coefficient and pulmonary extraction ratio for propofol. In the present investigation we compared both variables for propofol between goats and pigs during a propofol anaesthesia. In ten goats and ten pigs, expired alveolar gas and arterial and mixed venous blood samples were simultaneously drawn during total intravenous anaesthesia with propofol. The blood gas partition coefficient and pulmonary extraction ratio were calculated for both species. Non-parametric methods were used for statistical inference. The blood gas partition coefficient ranged between 7000 and 646,000 for goats and between 17,000 and 267,000 for pigs. The pulmonary extraction ratio ranged between 32.9% and 98.1% for goats and was higher for pigs, which ranged between -106.0% and 39.0%. The blood gas partition coefficient for propofol exceeded those for other known anaesthetic compounds so that it takes longer to develop a steady-state. The different pulmonary extraction rates in two species suggest that there are different ways to distribute propofol during the lung passage on its way from the blood to breathing gas. This species-specific difference has to be considered for methods using the alveolar gas for monitoring the propofol concentration in plasma.

  14. Using Willie's Acid-Base Box for Blood Gas Analysis (United States)

    Dietz, John R.


    In this article, the author describes a method developed by Dr. William T. Lipscomb for teaching blood gas analysis of acid-base status and provides three examples using Willie's acid-base box. Willie's acid-base box is constructed using three of the parameters of standard arterial blood gas analysis: (1) pH; (2) bicarbonate; and (3) CO[subscript…

  15. Apparatus and method for monitoring of gas having stable isotopes (United States)

    Clegg, Samuel M; Fessenden-Rahn, Julianna E


    Gas having stable isotopes is monitored continuously by using a system that sends a modulated laser beam to the gas and collects and transmits the light not absorbed by the gas to a detector. Gas from geological storage, or from the atmosphere can be monitored continuously without collecting samples and transporting them to a lab.

  16. Continuous measurement of transcutaneous oxygen tension of neonates under general anesthesia. (United States)

    Welle, P; Hayden, W; Miller, T


    Neonates present unique challenges to the anesthesiologist because of their susceptibility to oxygen toxicity and because clinical assessment of the degree of an infant's hypoxia is more difficult than in the adult. Equipment is now available for the continuous noninvasive measurement of transcutaneous oxygen tension. We used this equipment to monitor nine different neonates undergoing ten surgical procedures requiring general anesthesia. We found that certain of the infants were above and below what we considered to be a safe range for the transcutaneous oxygen tension for a significant portion of the surgery. Additionally, the manipulations of the surgeon and anesthesiologists were seen to cause sudden and large fluctuations in the transcutaneous oxygen tension. By providing the anesthesiologist with continuous and immediate data on the cardiorespiratory status of the infant, transcutaneous oxygen monitoring makes itself a valuable addition to the equipment used in the intraoperative monitoring of the neonate.

  17. Computer monitors natural-gas-liquids line

    Energy Technology Data Exchange (ETDEWEB)

    Muldoon, J.F.; Wilson, W.O.


    A new computer-based system continuously monitors composition, flow, and specific gravity of natural-gas liquids flowing in a pipeline. Compositional analysis is performed automatically, under computer control, by a process gas chromatograph. The chromatograph is tailored for hydrocarbon analysis and will separate these compounds into individual components: nitrogen, carbon dioxide, methane, ethane, propane, n-butane, isobutane, n-pentane, isopentane, 1-hexane, 2-hexane, 3-hexane, 4-hexane, and heptanes-and-heavier. At the completion of the analysis, the compositional totals, barrels, and pounds, are updated based on flow and average specific gravity. Reports generated include a compositional report, a subtotal ticket report, and a ticket report. The new system, designated Pro-PACE-100, has been successfully installed in several pipeline applications, including one for Mid-America Pipeline Co. in New Mexico.

  18. Inherently safe passive gas monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Cordaro, Joseph V.; Bellamy, John Stephen; Shuler, James M.; Shull, Davis J.; Leduc, Daniel R.


    Generally, the present disclosure is directed to gas monitoring systems that use inductive power transfer to safely power an electrically passive device included within a nuclear material storage container. In particular, the electrically passive device can include an inductive power receiver for receiving inductive power transfer through a wall of the nuclear material storage container. The power received by the inductive power receiver can be used to power one or more sensors included in the device. Thus, the device is not required to include active power generation components such as, for example, a battery, that increase the risk of a spark igniting flammable gases within the container.

  19. Cardiorespiratory and blood gas alterations during laparoscopic surgery for intra-uterine artificial insemination in dogs. (United States)

    Fukushima, Fabíola B; Malm, Christina; Andrade, Maria Elisa J; Oliveira, Humberto P; Melo, Eliane G; Caldeira, Fátima Maria C; Gheller, Valentim A; Palhares, Maristela S; Macedo, Sabrina P; Figueiredo, Mariana S; Silva, Marcos X


    Cardiorespiratory and blood gas alterations were evaluated in 6 healthy dogs that underwent a laparoscopic procedure using isoflurane anesthesia and carbon dioxide (CO(2)) pneumoperitoneum for 30 min. Heart rate, respiratory rate, body temperature, venous blood pH, partial pressure of CO(2) and oxygen, oxygen saturation, total carbon dioxide (TCO(2)) and bicarbonate were monitored. Significant alterations were hypercapnia, hypoventilation, and respiratory acidosis.

  20. A comparison of the incidence of hypercapnea in non-obese and morbidly obese peri-operative patients using the SenTec transcutaneous pCO(2) monitor. (United States)

    Soto, Roy G; Davis, Maurice; Faulkner, Michael J


    Obese patients are at increased risk for hypoventilation, leading to hypercapnea and acidosis. The primary objective of this study was to compare the incidence of perioperative hypercapnea in non-obese and morbidly obese patients using the SenTec transcutaneous PCO2 (tcPCO2) monitor. 10 morbidly obese subjects (BMI > 40 kg/m(2)) undergoing laparoscopic bariatric surgery, and 10 non-obese subjects (BMI < 30 kg/m(2)) undergoing laparoscopic abdominal procedures were studied, using a standardized anesthesia regimen. TcPCO2 and SpO2 were monitored continuously intraoperatively, and during the first 24 h postoperatively. Opiate consumption, respiratory rate (RR), and pain scores were collected from postanesthesia care unit (PACU) and ward nursing notes. RR, SpO2, and tcPCO2 did not differ significantly between groups during PACU or ward time periods. End-tidal CO2 (EtCO2) values were similar between groups during the intraoperative period, but tcPCO2 was significantly higher in the obese group at specific time points, and trended towards being higher throughout the case. Our study did not show significant tcPCO2 differences between non-obese and obese post-surgical patients, however, it did allow for continuous, trendable, nonobtrusive monitoring throughout the perioperative period. As V/Q mismatch increases with the PaCO2/EtCO2 gradient, and this effect is most pronounced in morbidly obese patients, tcPCO2 monitoring may prove to be a useful additional monitor in these patients during the intraoperative period.

  1. Wearable Beat to Beat Blood Pressure Monitor Project (United States)

    National Aeronautics and Space Administration — A key component of NASA's human exploration programs is a system that monitors the health of the crew during space missions. The wearable beat-to-beat blood pressure...

  2. Undisplayed Bicarbonate ion Concentration in Arterial Blood Gas Analysis



    Blood bicarbonate ion concentration (BcHCO3-) is a vital parameter in the management of acid base disorders. In an arterial blood gas (ABG) analyzer, the BcHCO3- is calculated from the values of pH and pCO2.

  3. 20 CFR 718.105 - Arterial blood-gas studies. (United States)


    ... gas exchange. This defect will manifest itself primarily as a fall in arterial oxygen tension either... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Arterial blood-gas studies. 718.105 Section... DEATH DUE TO PNEUMOCONIOSIS Criteria for the Development of Medical Evidence § 718.105 Arterial...

  4. Noble gas atmospheric monitoring at reprocessing facilities

    Energy Technology Data Exchange (ETDEWEB)

    Nakhleh, C.W.; Perry, R.T. Jr.; Poths, J.; Stanbro, W.D.; Wilson, W.B.; Fearey, B.L.


    The discovery in Iraq after the Gulf War of the existence of a large clandestine nuclear-weapon program has led to an across-the-board international effort, dubbed Programme 93+2, to improve the effectiveness and efficiency of International Atomic Energy Agency (IAEA) safeguards. One particularly significant potential change is the introduction of environmental monitoring (EM) techniques as an adjunct to traditional safeguards methods. Monitoring of stable noble gas (Kr, Xe) isotopic abundances at reprocessing plant stacks appears to be able to yield information on the burnup and type of the fuel being processed. To estimate the size of these signals, model calculations of the production of stable Kr, Xe nuclides in reactor fuel and the subsequent dilution of these nuclides in the plant stack are carried out for two case studies: reprocessing of PWR fuel with a burnup of 35 GWd/tU, and reprocessing of CAND fuel with a burnup of 1 GWd/tU. For each case, a maximum-likelihood analysis is used to determine the fuel burnup and type from the isotopic data.

  5. Role of ambulatory blood pressure monitoring in resistant hypertension. (United States)

    Grassi, Guido; Bombelli, Michele; Seravalle, Gino; Brambilla, Gianmaria; Dell'oro, Raffaella; Mancia, Giuseppe


    Ambulatory blood pressure monitoring has gained growing popularity in the diagnosis and treatment of essential hypertension for several reasons, such as the lack of the so-called white-coat effect, the greater reproducibility as compared with clinic blood pressure, the ability to provide information on blood pressure phenomena of prognostic value and the closer relationship with the risk of cardiovascular morbidity and mortality. All the above-mentioned main features of ambulatory blood pressure monitoring are also true for resistant hypertension. In addition, however, in resistant hypertension, blood pressure monitoring allows one to precisely define the diagnosis of this clinical condition, by excluding the presence of white-coat hypertension, which is responsible for a consistent number of "false" resistant hypertensive cases. The approach also allows one to define the patterns of blood pressure variability in this clinical condition, as well as its relationships with target organ damage. Finally, it allows one to assess the effects of therapeutic interventions, such as renal nerves ablation, aimed at improving blood pressure control in this hypertensive state. The present paper will critically review the main features of ambulatory blood pressure monitoring in resistant hypertension, with particular emphasis on the diagnosis and treatment of this high-risk hypertensive state.

  6. Squeezing red blood cells on an optical waveguide to monitor cell deformability during blood storage. (United States)

    Ahluwalia, Balpreet Singh; McCourt, Peter; Oteiza, Ana; Wilkinson, James S; Huser, Thomas R; Hellesø, Olav Gaute


    Red blood cells squeeze through micro-capillaries as part of blood circulation in the body. The deformability of red blood cells is thus critical for blood circulation. In this work, we report a method to optically squeeze red blood cells using the evanescent field present on top of a planar waveguide chip. The optical forces from a narrow waveguide are used to squeeze red blood cells to a size comparable to the waveguide width. Optical forces and pressure distributions on the cells are numerically computed to explain the squeezing process. The proposed technique is used to quantify the loss of blood deformability that occurs during blood storage lesion. Squeezing red blood cells using waveguides is a sensitive technique and works simultaneously on several cells, making the method suitable for monitoring stored blood.

  7. Wearable Beat-to-Beat Blood Pressure Monitor (United States)

    Lee, Yong Jin


    Linea Research Corporation has developed a wearable noninvasive monitor that provides continuous blood pressure and heart rate measurements in extreme environments. Designed to monitor the physiological effects of astronauts' prolonged exposure to reduced-gravity environments as well as the effectiveness of various countermeasures, the device offers wireless connectivity to allow transfer of both real-time and historical data. It can be modified to monitor the health status of astronaut crew members during extravehicular missions.

  8. Cuff inflation during ambulatory blood pressure monitoring and heart rate

    Directory of Open Access Journals (Sweden)

    Mia Skov-Madsen


    Full Text Available Mia Skov-Madsen, My Svensson, Jeppe Hagstrup ChristensenDepartment of Nephrology, Aarhus University Hospital, Aalborg, DenmarkIntroduction: Twenty four-hour ambulatory blood pressure monitoring is a clinically validated procedure in evaluation of blood pressure (BP. We hypothesised that the discomfort during cuff inflation would increase the heart rate (HR measured with 24-h ambulatory BP monitoring compared to a following HR measurement with a 24-h Holter monitor.Methods: The study population (n = 56 were recruited from the outpatient’s clinic at the Department of Nephrology, Aalborg Hospital, Aarhus University Hospital at Aalborg, Denmark. All the patients had chronic kidney disease (CKD. We compared HR measured with a 24-h Holter monitor with a following HR measured by a 24-h ambulatory BP monitoring.Results: We found a highly significant correlation between the HR measured with the Holter monitor and HR measured with 24-h ambulatory blood pressure monitoring (r = 0.77, p < 0.001. Using the Bland-Altman plot, the mean difference in HR was only 0.5 beat/min during 24 hours with acceptable limits of agreement for both high and low HR levels. Dividing the patients into groups according to betablocker treatment, body mass index, age, sex, angiotensin-converting enzyme inhibitor treatment, statins treatment, diuretic treatment, or calcium channel blocker treatment revealed similar results as described above.Conclusion: The results indicate that the discomfort induced by cuff inflation during 24-h ambulatory BP monitoring does not increase HR. Thus, 24-h ambulatory BP monitoring may be a reliable measurement of the BP among people with CKD.Keywords: ambulatory blood pressure monitoring, Holter monitoring, heart rate, chronic kidney disease, hypertension

  9. Condition monitoring of rotary blood pumps. (United States)

    Jammu, V B; Malanoski, S; Walter, T; Smith, W


    Long-term, trouble-free operation of ventricular assist devices (VADs) is critical to the patient. A catastrophic failure of the VAD could cost the patient's life, thus defeating the purpose of the device. The targeted 90% 5 year reliability also implies that the average device life would exceed the 5 year limit. Time based explantation of the device after the fifth year will replace many devices with significant additional life, subject the patient to unnecessary surgical risk, and increase costs. To preclude the need for time based replacements and prevent catastrophic failures, a condition monitor is proposed in this article for early detection of faults in VADs. To develop this monitor, the effectiveness of various sensing and monitoring methods for determining the VAD condition is investigated. A Hemadyne pump was instrumented with a set of eight sensors, and a series of experiments were performed to record and analyze signals from the normal and abnormal pumps with five different faults. Statistical, spectral, envelope, and ensemble averaging analyses were performed to characterize changes in sensor signals due to faults. Experimental results indicate that statistical and frequency information from the acceleration and dynamic pressure signals can clearly detect and identify various VAD faults.

  10. Dependence of transcutaneous oxygen tension on local arteriovenous pressure gradient in normal subjects. (United States)

    Wyss, C R; Matsen, F A; King, R V; Simmons, C W; Burgess, E M


    1. We studied the relationship between transcutaneous oxygen tension at the foot and local arteriovenous pressure difference in 15 normal men and women; arteriovenous pressure difference was varied by changing the height of the foot with respect to the heart and by applying external pressure to the foot. 2. Control transcutaneous oxygen tension was 67 +/- 9 SD mmHg (8.9 +/- 1.2 kPa) at a control arteriovenous pressure difference of 80 +/- 6 SD mmHg (10.6 +/- 0.8 kPa). 3. In every subject transcutaneous oxygen tension fell non-linearly with a decrease in arteriovenous pressure difference; transcutaneous oxygen tension was relatively insensitive to changes in arteriovenous pressure difference when arteriovenous pressure difference was high, but always fell sharply to zero at some positive arteriovenous pressure difference [range 13-34 mmHg (1.7-4.5 kPa)]. 4. An analysis of the data indicated that transcutaneous oxygen tension varied with arteriovenous pressure difference approximately as the oxygen tension of cutaneous venous blood under the sensor varied (in the absence of changes in cutaneous vascular resistance and oxygen consumption). 5. This analysis was supported by studies in three subjects in whom the oxygen tension of superficial venous drainage from a warmed hand or foot was measured along with transcutaneous oxygen tension while arteriovenous pressure difference was varied.

  11. A Microprocessor-Based System for Monitoring Gas Turbines

    Directory of Open Access Journals (Sweden)

    P. K.S. Shrivastava


    Full Text Available The development and testing of hardware and software for a microprocessor-based monitoring system for gas turbines is described in this paper. The operators of gas turbines can be trained to monitor running hours, slip between high and low pressure compressor spools and torque on the reduction gear-box under various conditions ofoperation. The system will replace the traditional method of monitoring these parameters which are more time consuming and error prone.

  12. [Verification of complete blood cell count (CBC) data from heparinized blood gas samples]. (United States)

    Sakoguchi, Takafumi; Fujii, Seiji; Inuzumi, Koji; Kaminoh, Yoshiroh; Hirose, Munetaka; Masaki, Mitsuru; Koshiba, Masahiro


    Complete blood cell count (CBC) data from heparinized blood gas (H-Gas) samples were verified with primary focus on the platelet count (PLT). When a part of H-Gas sample was taken to a separation tube from the blood collection syringe and CBC of the sample in the separation tube was repeatedly measured (Procedure 1), the PLT from 5 samples relative to that obtained immediately after the separation was gradually reduced to 72.6-94.2% during serial measurements (every 5 minutes, up to 30 minutes). The change in the scattergram pattern suggested that this PLT decrease was due to the formation of platelet clumps. The white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb) and hematocrit (Ht) values did not significantly change during the repeated measurements. On the other hand, PLT was significantly improved to 96.8-99.8% when the H-Gas sample was kept in the blood collection syringe so as to minimizing the exposure to the air, and the sample for the measurement from H-Gas was taken every time to separation tube from the syringe, followed by CBC measurement without delay (Procedure 2). In addition, while there were significant variations (CV: 11.8-18.2%) in PLT reproducibility among H-Gas samples by Procedure 1, measurements utilizing the Procedure 2 resulted in much smaller variations (CV: 2.2-3.7%). Thus the CBC data obtained from H-Gas samples were equivalent to those from EDTA samples when the Procedure 2 was applied. These data suggest that H-Gas samples can be used for the accurate CBC measurement, including PLT, by applying the Procedure 2.

  13. Engineering considerations for corrosion monitoring of gas gathering pipeline systems

    Energy Technology Data Exchange (ETDEWEB)

    Braga, T.G.; Asperger, R.G.


    Proper corrosion monitoring of gas gathering pipelines requires a system review to determine the appropriate monitor locations and types of monitoring techniques. This paper develops and discusses a classification of conditions such as flow regime and gas composition. Also discussed are junction categories which, for corrosion monitoring, need to be considered from two points of view. The first is related to fluid flow in the line and the second is related corrosion inhibitor movement along the pipeline. The appropriate application of the various monitoring techniques such as coupons, hydrogen detectors, electrical resistance probe and linear polarization probes are discussed in relation to flow regime and gas composition. Problems caused by semi-conduction from iron sulfide are considered. Advantages and disadvantages of fluid gathering methods such as pots and flow-through drips are discussed in relation to their reliability as on-line monitoring locations.

  14. Hydrogen and Oxygen Gas Monitoring System Design and Operation

    Energy Technology Data Exchange (ETDEWEB)

    Lee C. Cadwallader; Kevin G. DeWall; J. Stephen Herring


    This paper describes pertinent design practices of selecting types of monitors, monitor unit placement, setpoint selection, and maintenance considerations for gas monitors. While hydrogen gas monitors and enriched oxygen atmosphere monitors as they would be needed for hydrogen production experiments are the primary focus of this paper, monitors for carbon monoxide and carbon dioxide are also discussed. The experiences of designing, installing, and calibrating gas monitors for a laboratory where experiments in support of the DOE Nuclear Hydrogen Initiative (NHI) are described along with codes, standards, and regulations for these monitors. Information from the literature about best operating practices is also presented. The NHI program has two types of activities. The first, near-term activity is laboratory and pilot-plant experimentation with different processes in the kilogram per day scale to select the most promising types of processes for future applications of hydrogen production. Prudent design calls for indoor gas monitors to sense any hydrogen leaks within these laboratory rooms. The second, longer-term activity is the prototype, or large-scale plants to produce tons of hydrogen per day. These large, outdoor production plants will require area (or “fencepost”) monitoring of hydrogen gas leaks. Some processes will have oxygen production with hydrogen production, and any oxygen releases are also safety concerns since oxygen gas is the strongest oxidizer. Monitoring of these gases is important for personnel safety of both indoor and outdoor experiments. There is some guidance available about proper placement of monitors. The fixed point, stationary monitor can only function if the intruding gas contacts the monitor. Therefore, monitor placement is vital to proper monitoring of the room or area. Factors in sensor location selection include: indoor or outdoor site, the location and nature of potential vapor/gas sources, chemical and physical data of the

  15. Noninvasive 24-hour ambulatory arterial blood pressure monitoring in cirrhosis

    DEFF Research Database (Denmark)

    Møller, Søren; Wiinberg, N; Henriksen, Jens Henrik


    Cirrhotic patients have disturbed systemic hemodynamics with reduced arterial blood pressure, but this has not been investigated during daily activity and sleep. Systolic (SBP), diastolic (DBP), and mean arterial blood pressure (MAP), and heart rate (HR) were measured by an automatic ambulant...... device for monitoring blood pressure in 35 patients with cirrhosis and 35 healthy matched controls. During the daytime, SBP, DBP, and MAP were significantly lower in the patients than in the controls (median 118 vs. 127; 70 vs. 78; 86 vs. 94 mm Hg, P blood pressures...... were almost similar in the two groups (108 vs. 110; 65 vs. 67; 78 vs. 82 mm Hg, NS). Conversely, HR was significantly higher in the patients both in the daytime (86 vs. 72/min, P blood pressure and HR from daytime...

  16. Coal mine gas monitoring system based on wireless sensor network

    Institute of Scientific and Technical Information of China (English)

    WANG Jian; WANG Ru-lin; WANG Xue-min; SHEN Chuan-he


    Based on the nowadays' is urgent that the gas detection cable communication system must be replaced by the wireless communication systems.The wireless sensors distributed in the environment can achieve the intelligent gas monitoring system.Apply with multilayer data fuse to design working tactics,and import the artificial neural networks to analyze detecting result.The wireless sensors system communicates with the controI center through the optical fiber cable.All the gas sensor nodes distributed in coal mine are combined into an intelligent,flexible structure wireless network system.forming coal mine gas monitoring system based on wireless sensor network.

  17. 21 CFR 870.4410 - Cardiopulmonary bypass in-line blood gas sensor. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary bypass in-line blood gas sensor... Cardiopulmonary bypass in-line blood gas sensor. (a) Identification. A cardiopulmonary bypass in-line blood gas sensor is a transducer that measures the level of gases in the blood. (b) Classification. Class...

  18. Transcutaneous Raman Spectroscopy of Bone (United States)

    Maher, Jason R.

    Clinical diagnoses of bone health and fracture risk typically rely upon measurements of bone density or structure, but the strength of a bone is also dependent upon its chemical composition. One technology that has been used extensively in ex vivo, exposed-bone studies to measure the chemical composition of bone is Raman spectroscopy. This spectroscopic technique provides chemical information about a sample by probing its molecular vibrations. In the case of bone tissue, Raman spectra provide chemical information about both the inorganic mineral and organic matrix components, which each contribute to bone strength. To explore the relationship between bone strength and chemical composition, our laboratory has contributed to ex vivo, exposed-bone animal studies of rheumatoid arthritis, glucocorticoid-induced osteoporosis, and prolonged lead exposure. All of these studies suggest that Raman-based predictions of biomechanical strength may be more accurate than those produced by the clinically-used parameter of bone mineral density. The utility of Raman spectroscopy in ex vivo, exposed-bone studies has inspired attempts to perform bone spectroscopy transcutaneously. Although the results are promising, further advancements are necessary to make non-invasive, in vivo measurements of bone that are of sufficient quality to generate accurate predictions of fracture risk. In order to separate the signals from bone and soft tissue that contribute to a transcutaneous measurement, we developed an overconstrained extraction algorithm that is based upon fitting with spectral libraries derived from separately-acquired measurements of the underlying tissue components. This approach allows for accurate spectral unmixing despite the fact that similar chemical components (e.g., type I collagen) are present in both soft tissue and bone and was applied to experimental data in order to transcutaneously detect, to our knowledge for the first time, age- and disease-related spectral

  19. Gas pipeline monitoring in Europe by Satellite SAR

    NARCIS (Netherlands)

    Smith, A.J.E.


    At present, gas pipeline networks in Europe are routinely monitored by vehicle and air patrols to protect them against damage by soil movement and third part interference. Because of the expenses, pipeline operators are investigating the possibilities to replace these traditional monitoring methods

  20. Ambulatory blood pressure monitoring during pregnancy with a new, small, easily concealed monitor. (United States)

    Tape, T G; Rayburn, W F; Bremer, K D; Schnoor, T A


    Before establishing the utility of ambulatory blood pressure monitoring during pregnancy, we evaluated the accuracy of a small, easily concealed monitor. The 59 normotensive pregnant patients were between 13 and 26 gestational weeks. For each monitor reading, two trained observers independently and simultaneously recorded blood pressures using a mercury manometer connected to the monitor cuff. Seven readings in three positions (sitting upright, semirecumbent, standing) were performed on each patient. Averaged differences between the observers' and monitor readings varied from -2.2 to -0.9 mm Hg (systolic) and from -2.8 to -0.6 (fifth-phase diastolic), indicating slight but clinically unimportant overestimation by the monitor. Correlations between averaged observers' readings and the monitor ranged from 0.79 to 0.92 (systolic) and from 0.85 to 0.92 (fifth-phase diastolic). Overall, the observers agreed with the monitor within 5 mm Hg on 94% of systolic readings and 99% of fifth-phase diastolic readings. There was no statistically significant difference in accuracy with changes in body position. We conclude that this small, quiet, noninvasive device accurately determined blood pressures during pregnancy.

  1. Photoacoustic monitoring and imaging of blood vessels in tissue (United States)

    Kolkman, Roy G. M.; Pilatou, Magdalena C.; Steenbergen, Wiendelt; de Mul, Frits F. M.


    Using very sensitive photoacoustical detectors we localized and monitored the blood content in tissue. In these detectors a PVdF-layer has been used as piezo-electric material and also fibers for the illumination of the sample are integrated. The resolution is about 20micrometers in depth and about 50-100micrometers laterally. The wavelengths of the laser light were 532 and 1064 nm. With these colors we can measure at different depths in tissue. The measurements concerned blood perfusion in real tissue: vessels in chicken breast, in test animals at various positions and in the human arm.

  2. Oscillometric continuous blood pressure sensing for wearable health monitoring system

    CERN Document Server

    Gelao, Gennaro; Passaro, Vittorio M N; Perri, Anna Gina


    In this paper we present an acquisition chain for the measurement of blood arterial pressure based on the oscillometric method. This method does not suffer from any limitation as the well-known auscultatory method and it is suited for wearable health monitoring systems. The device uses a pressure sensor whose signal is filtered, digitalized and analyzed by a microcontroller. Local analysis allows the evaluation of the systolic and diastolic pressure values which can be used for local alarms, data collection and remote monitoring.

  3. High-rangeability ultrasonic gas flowmeter for monitoring flare gas. (United States)

    Mylvaganam, K S


    A transit-time ultrasonic gas flowmeter for high-rangeability requirements, such as those encountered in flare-gas flow-metering, is presented. The concept of ray rescue angle for the orientation of the ultrasonic transducers in single-beam transit-time ultrasonic flowmeters is introduced to overcome the problem of ultrasonic beam drift in high-velocity flows. To overcome problems associated with noise at high velocities, a chirp signal is used. To preserve the accuracy of the meter at low velocities near zero flow, a combination of chirp and continuous-wave signals is used to interrogate the flow. Overall system performance is presented, based on results from extensive wind-tunnel tests.

  4. New mud gas monitoring system aboard D/V Chikyu (United States)

    Kubo, Yusuke; Inagaki, Fumio; Eguchi, Nobuhisa; Igarashi, Chiaki


    Mud gas logging has been commonly used in oil industry and continental scientific drilling to detect mainly hydrocarbon gases from the reservoir formation. Quick analysis of the gas provides almost real-time information which is critical to evaluate the formation and, in particular, safety of drilling operation. Furthermore, mud gas monitoring complements the lack of core or fluid samples particularly in a deep hole, and strengthen interpretations of geophysical logs. In scientific ocean drilling, on the other hand, mud gas monitoring was unavailable in riserless drilling through the history of DSDP and ODP, until riser drilling was first carried out in 2009 by D/V Chikyu. In IODP Exp 319, GFZ installed the same system with that used in continental drilling aboard Chikyu. High methane concentrations are clearly correlated with increased wood content in the cuttings. The system installation was, however, temporary and gas separator was moved during the expedition for a technical reason. In 2011, new mud gas monitoring system was installed aboard Chikyu and was used for the first time in Exp 337. The gas separator was placed on a newly branched bypass mud flow line, and the gas sample was sent to analysis unit equipped with methane carbon isotope analyzer in addition to mass spectrometer and gas chromatograph. The data from the analytical instruments is converted to depth profiles by calculating the lag effects due to mud circulation. Exp 337 was carried out from July 26 to Sep 30, 2011, at offshore Shimokita peninsula, northeast Japan, targeting deep sub-seafloor biosphere in and around coal bed. Data from the hole C0020A, which was drilled to 2466 mbsf with riser drilling, provided insights into bio-geochemical process through the depth of the hole. In this presentation, we show the design of Chikyu's new mud gas monitoring system, with preliminary data from Exp 337.

  5. Laser Doppler perfusion monitoring and imaging of blood microcirculation (United States)

    Nilsson, Gert E.; Wardell, Karin


    Laser Doppler perfusion monitoring is a method of assessing tissue perfusion based on measurements performed using Doppler broadening of monochromatic light scattered in moving blood cells. Ever since laser Doppler perfusion monitors became available about 15 years ago they have been used in numerous applications in both clinical and laboratory settings. The high spatial resolution has in practice manifested itself as one of the main limitations of the method. The reason for this is the difficulty in attaining reproducible values at successive measurement sites because most skin tissue possesses a substantial variation in blood flow even at adjacent measurement sites. In order to overcome this difficulty the laser Doppler perfusion imager was developed. In this camera-like device, the laser beam successively scans the tissue and the Doppler components of the backscattered light are detected by a remote photodiode. After a scanning procedure is complete, a color-coded perfusion map showing the spatial variation of skin blood flow is displayed on a monitor. The operating principle and early applications of this emerging technology are addressed in further detail.

  6. Magnetic sensor for arterial distension and blood pressure monitoring. (United States)

    Ruhhammer, Johannes; Herbstritt, Tamara; Ruh, Dominic; Foerster, Katharina; Heilmann, Claudia; Beyersdorf, Friedhelm; Goldschmidtboeing, Frank; Seifert, Andreas; Woias, Peter


    A novel sensor for measuring arterial distension, pulse and pressure waveform is developed and evaluated. The system consists of a magnetic sensor which is applied and fixed to arterial vessels without any blood vessel constriction, hence avoiding stenosis. The measurement principle could be validated by in vitro experiments on silicone tubes, and by in vivo experiments in an animal model, thereby indicating the non-linear viscoelastic characteristics of real blood vessels. The sensor is capable to provide absolute measurements of the dynamically varying arterial diameter. By calibrating the sensor, a long-term monitoring system for continuously measuring blood pressure and other cardiovascular parameters could be developed based on the method described. This will improve diagnostics for high risk patients and enable a better, specific treatment.

  7. Noninvasive 24-hour ambulatory arterial blood pressure monitoring in cirrhosis

    DEFF Research Database (Denmark)

    Møller, Søren; Wiinberg, N; Henriksen, Jens Henrik


    were almost similar in the two groups (108 vs. 110; 65 vs. 67; 78 vs. 82 mm Hg, NS). Conversely, HR was significantly higher in the patients both in the daytime (86 vs. 72/min, P pressure and HR from daytime......Cirrhotic patients have disturbed systemic hemodynamics with reduced arterial blood pressure, but this has not been investigated during daily activity and sleep. Systolic (SBP), diastolic (DBP), and mean arterial blood pressure (MAP), and heart rate (HR) were measured by an automatic ambulant...... device for monitoring blood pressure in 35 patients with cirrhosis and 35 healthy matched controls. During the daytime, SBP, DBP, and MAP were significantly lower in the patients than in the controls (median 118 vs. 127; 70 vs. 78; 86 vs. 94 mm Hg, P pressures...

  8. [Development of ultrasound-based monitor of relative blood volume]. (United States)

    Jiang, Shunzhong; Hu, Xiao; Liang, Zhongwei; Fan, Jianghong; Xia, Wubing; Zhou, Hongbo; Yi, Wei


    Assessing dry weight accurately is crucial in providing effective and safe haemodialysis. Biases towards dry weight assessment may bring a series of dialysis complications. This study introduces an online detection technique of relative blood volume (RBV) based on ultrasound, which analyzes the correlation between changes in blood density and sound speed. By measuring the attenuation in sound velocity, this method was employed to calculate RBV, and then to evaluate the dry weight of patients on dialysis. TDC-GP2 time measurement chip and MSP430 Single-chip Microcontroller (SCM) were used in the system to measure the ultrasonic travel time. In the clinical trials, RBV values range between 71.3% and 108.1%, showing consistent result with Fresenius 4008S blood volume monitor (BVM). This detection method possesses several advantages, such as real time, convenient, reproducible, non-invasive, and etc.

  9. A Gas Monitoring and Control System in a Coal and Gas Outburst Laboratory

    Directory of Open Access Journals (Sweden)

    W. Nie


    Full Text Available Coal and gas outburst is a phenomenon characterized by the ejection of gas and coal from the solid face of a mine. Physical minioutburst experiments are a very important tool for analyzing outbursts of coal and gas. However, few reports have focused on the safety problem produced by gas concentration or the role of gas spread during the physical experiments. In this study, we designed a simple monitoring and control system for the safety of staff during the minioutburst experiments. The results showed that, in the simulation of four dangerous situations, the system based on a sensors feedback loop can monitor the development of gas content in the temporal and spatial domains for the enhancement of accurate warnings. The system also automatically chooses the appropriate ventilation measures to lower the gas content considering different degrees of danger.

  10. Operating experience review of an INL gas monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Cadwallader, Lee C. [Idaho National Lab. (INL), Idaho Falls, ID (United States); DeWall, K. G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Herring, J. S. [Idaho National Lab. (INL), Idaho Falls, ID (United States)


    This article describes the operations of several types of gas monitors in use at the Idaho National Laboratory (INL) High Temperature Electrolysis Experiment (HTE) laboratory. The gases monitored in the lab room are hydrogen, carbon monoxide, carbon dioxide, and oxygen. The operating time, calibration, and both actual and unwanted alarms are described. The calibration session time durations are described. In addition, some simple calculations are given to estimate the reliability of these monitors and the results are compared to operating experiences of other types of monitors.

  11. Transcutaneous Determination of Arterial Oxygen Tension (United States)

    Fenner, A.; And Others


    Evaluated were two techniques (the conventional method and the new transcutaneous method) of measuring arterial oxygen tension in 20 severely ill preterm and term infants and in 70 healthy infants. (Author/CL)

  12. Monitoring blood flow and photobleaching during topical ALA PDT treatment (United States)

    Sands, Theresa L.; Sunar, Ulas; Foster, Thomas H.; Oseroff, Allan R.


    Photodynamic therapy (PDT) using topical aminolevulinic acid (ALA) is currently used as a clinical treatment for nonmelanoma skin cancers. In order to optimize PDT treatment, vascular shutdown early in treatment must be identified and prevented. This is especially important for topical ALA PDT where vascular shutdown is only temporary and is not a primary method of cell death. Shutdown in vasculature would limit the delivery of oxygen which is necessary for effective PDT treatment. Diffuse correlation spectroscopy (DCS) was used to monitor relative blood flow changes in Balb/C mice undergoing PDT at fluence rates of 10mW/cm2 and 75mW/cm2 for colon-26 tumors implanted intradermally. DCS is a preferable method to monitor the blood flow during PDT of lesions due to its ability to be used noninvasively throughout treatment, returning data from differing depths of tissue. Photobleaching of the photosensitizer was also monitored during treatment as an indirect manner of monitoring singlet oxygen production. In this paper, we show the conditions that cause vascular shutdown in our tumor model and its effects on the photobleaching rate.

  13. Pediatric ambulatory blood pressure monitoring: indications and interpretations. (United States)

    Flynn, Joseph T; Urbina, Elaine M


    The prevalence of hypertension in children and adolescents is increasing, especially in obese and ethnic children. The adverse long-term effects of hypertension beginning in youth are known; therefore, it is important to identify young patients who need intervention. Unfortunately, measuring blood pressure (BP) is difficult due to the variety of techniques available and innate biologic variation in BP levels. Ambulatory BP monitoring may overcome some of the challenges clinicians face when attempting to categorize a young patient's BP levels. In this article, the authors review the use of ambulatory BP monitoring in pediatrics, discuss interpretation of ambulatory BP monitoring, and discuss gaps in knowledge in usage of this technique in the management of pediatric hypertension.

  14. Development of oil and gas sector monitoring in Perm territory

    Directory of Open Access Journals (Sweden)

    Galina Vasil'evna Kutergina


    Full Text Available This paper reviews current approaches to the definition of «regional monitoring» and its contents. The work is based on the use of a systematic approach to the analysis of regional monitoring, reviewing it as part of the overall control system and risk management in the region.Organization of regional monitoring is considered on the example of oil and gas complex (OGC of Perm territory. This paper summarizes the structure of the OGC, the specific features of the activities of the enterprises that have the most significant impact on the organization of monitoring. The findings are based on an analysis and compilation of statistics. Authors consider in most details the subjects and objects of state and corporate level monitoring of the regional OGC in Perm territory, their main function of monitoring, interoperability issues, methodological support of various institutions in the periodic monitoring of OGC - the audit committees and internal audit units. Proposals for the development in most parts refer to the use of risk-oriented approach to organizing periodic monitoring of oil and gas industry in the territory on the basis of a common methodology for assessing its effectiveness. The proposals to expand cooperation between state agencies and regional bodies of governance of OGC enterprises in Perm territory on a wide range of areas of the organization of monitoring: the exchange of professional information, methodology, activities, staff and others.


    Directory of Open Access Journals (Sweden)

    Sandhu Premjeet


    Full Text Available Conventional drug delivery systems are often not suitable for new protein based and other Therapeutic compounds produced by modern technology. Therefore an alternative Approach to deliver these drugs can be achieved through the skin in the form of transcutaneous drug delivery system. Modern medicine has responded with the development of methods to deliver drug transcutanously (through the skin for therapeutic use as an alternative to traditional route including oral, intravascular, intramuscular, subcutaneous, and sublingual. Transcutaneous drug delivery has many theoretic and practical advantage and disadvantages, and such issues are often a concern for both clinicians and patients. Transcutaneous patches are flexible pharmaceutical preparations of varying sizes, containing one or more active ingredient, intended to be applied to the unbroken skin in order to deliver the active ingredient to the systemic circulation after passing through the skin barriers. A Transcutaneous patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. In this method, the drug enters the bloodstream directly through skin and it avoid first pass effect. Characterization of Transcutaneous patch are necessary because check it’s quality, size, time of onset & duration, adhesive property, thickness, weight of patch, moisture of content, uniformity & cutaneous toxicological studies. Their requirements for evaluation are HPLC, U.V. spectrophotometer, screw gauge, digital balance, desiccators, thin layer chromatography & K.C. Cell used.

  16. Infrared spectroscopy for monitoring gas hydrates in aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Dobbs, G.T.; Luzinova, Y.; Mizaikoff, B. [Georgia Inst. of Technology, Atlanta, GA (United States). School of Chemistry and Biochemistry; Raichlin, Y.; Katzir, A. [Tel-Aviv Univ., Tel-Aviv (Israel). Shool of Physics and Astronomy


    This paper introduced the first principles for monitoring gas hydrate formation and dissociation in aqueous solution by evaluating state-responsive infrared (IR) absorption features of water with fiberoptic evanescent field spectroscopy. A first order linear functional relationship was also derived according to Lambert Beer's law in order to quantify the percentage gas hydrate within the volume of water probed via the evanescent field. In addition, spectroscopic studies evaluating seafloor sediments collected from a gas hydrate site in the Gulf of Mexico revealed minimal spectral interferences from sediment matrix components. As such, evanescent field sensing strategies were established as a promising perspective for monitoring the dynamics of gas hydrates in oceanic environments. 21 refs., 5 figs.

  17. Real-time trend monitoring of gas compressor stations

    Energy Technology Data Exchange (ETDEWEB)

    Van Hardeveld, T. (Nova, an Alberta Corp., AB (Canada))


    The authors' company has developed a machinery health monitoring system (MHealth) for short-term and long-term historical trending and analysis of data from its 40 gas compressor stations. The author discusses the benefits of real-time trending in troubleshooting operations, in preventative maintenance scheduling and cites specific applications in the startup operations of several new gas compressor/centrifugal compressor units.

  18. Postocclusive Hyperemia Measured with Laser Doppler Flowmetry and Transcutaneous Oxygen Tension in the Diagnosis of Primary Raynaud's Phenomenon: A Prospective, Controlled Study. (United States)

    Maga, Paweł; Henry, Brandon Michael; Kmiotek, Elizabeth K; Gregorczyk-Maga, Iwona; Kaczmarczyk, Paweł; Tomaszewski, Krzysztof A; Niżankowski, Rafał


    The aim of this study was to measure the sensitivity and specificity of transcutaneous oxygen tension and postocclusive hyperemia testing using laser Doppler flowmetry in patients with primary Raynaud's phenomenon. One hundred patients and one hundred controls were included in the study. Baseline microvascular blood flow and then time to peak flow following occlusion were measured using laser Doppler flowmetry. Afterwards, the transcutaneous oxygen tension was recorded. The sensitivities of baseline microvascular blood flow, postocclusive time to peak flow, and transcutaneous oxygen tension were 79%, 79%, and 77%, respectively. The postocclusive time peak flow had a superior specificity of 90% and area under the curve of 0.92 as compared to 66% and 0.80 for baseline microvascular flow and 64% and 0.76 for transcutaneous oxygen tension. Time to postocclusive peak blood flow measured by laser Doppler flowmetry is a highly accurate test for differentiating patients with primary Raynaud's phenomenon from healthy controls.

  19. Postocclusive Hyperemia Measured with Laser Doppler Flowmetry and Transcutaneous Oxygen Tension in the Diagnosis of Primary Raynaud's Phenomenon: A Prospective, Controlled Study (United States)

    Maga, Paweł; Henry, Brandon Michael; Kmiotek, Elizabeth K.; Gregorczyk-Maga, Iwona; Kaczmarczyk, Paweł; Niżankowski, Rafał


    The aim of this study was to measure the sensitivity and specificity of transcutaneous oxygen tension and postocclusive hyperemia testing using laser Doppler flowmetry in patients with primary Raynaud's phenomenon. One hundred patients and one hundred controls were included in the study. Baseline microvascular blood flow and then time to peak flow following occlusion were measured using laser Doppler flowmetry. Afterwards, the transcutaneous oxygen tension was recorded. The sensitivities of baseline microvascular blood flow, postocclusive time to peak flow, and transcutaneous oxygen tension were 79%, 79%, and 77%, respectively. The postocclusive time peak flow had a superior specificity of 90% and area under the curve of 0.92 as compared to 66% and 0.80 for baseline microvascular flow and 64% and 0.76 for transcutaneous oxygen tension. Time to postocclusive peak blood flow measured by laser Doppler flowmetry is a highly accurate test for differentiating patients with primary Raynaud's phenomenon from healthy controls. PMID:28101516

  20. Optical coherence tomography for blood glucose monitoring through signal attenuation (United States)

    De Pretto, Lucas R.; Yoshimura, Tania M.; Ribeiro, Martha S.; de Freitas, Anderson Z.


    Development of non-invasive techniques for glucose monitoring is crucial to improve glucose control and treatment adherence in patients with diabetes. Hereafter, Optical Coherence Tomography (OCT) may offer a good alternative for portable glucometers, since it uses light to probe samples. Changes in the object of interest can alter the intensity of light returning from the sample and, through it, one can estimate the sample's attenuation coefficient (μt) of light. In this work, we aimed to explore the behavior of μt of mouse's blood under increasing glucose concentrations. Different samples were prepared in four glucose concentrations using a mixture of heparinized blood, phosphate buffer saline and glucose. Blood glucose concentrations were measured with a blood glucometer, for reference. We have also prepared other samples diluting the blood in isotonic saline solution to check the effect of a higher multiple-scattering component on the ability of the technique to differentiate glucose levels based on μt. The OCT system used was a commercial Spectral Radar OCT with 930 nm central wavelength and spectral bandwidth (FWHM) of 100 nm. The system proved to be sensitive for all blood glucose concentrations tested, with good correlations with the obtained attenuation coefficients. A linear tendency was observed, with an increase in attenuation with higher values of glucose. Statistical difference was observed between all groups (p<0.001). This work opens the possibility towards a non-invasive diagnostic modality using OCT for glycemic control, which eliminates the use of analytes and/or test strips, as in the case with commercially available glucometers.

  1. Ambulatory Blood Pressure Monitoring – Clinical Practice Recommendations

    Directory of Open Access Journals (Sweden)

    Katalin Mako


    Full Text Available Ambulatory blood pressure monitoring (ABPM became a subject of considerable scientific interest. Due to the increasing use of the ABPM in everyday clinical practice it is important that all the users have a correct knowledge on the clinical indications, the methodology of using the device including some technical issues and the interpretation of results. In the last years several guidelines and position papers have been published with recommendations for the monitoring process, reference values, for clinical practice and research. This paper represents a summary of the most important aspects related to the use of ABPM in daily practice, being a synthesis of recommendations from the recent published guidelines and position papers. This reference article presents the practical and technical issues of ABPM, the use of this method in special situations, the clinical interpretation of measured values including the presentation of different ABPM patterns, derived parameters, the prognostic significance and the limitations of this method.

  2. High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels (United States)

    Petrov, Irene Y.; Petrov, Yuriy; Prough, Donald S.; Esenaliev, Rinat O.


    Ultrasound imaging is being widely used in clinics to obtain diagnostic information non-invasively and in real time. A high-resolution ultrasound imaging platform, Vevo (VisualSonics, Inc.) provides in vivo, real-time images with exceptional resolution (up to 30 microns) using high-frequency transducers (up to 80 MHz). Recently, we built optoacoustic systems for probing radial artery and peripheral veins that can be used for noninvasive monitoring of total hemoglobin concentration, oxyhemoglobin saturation, and concentration of important endogenous and exogenous chromophores (such as ICG). In this work we used the high-resolution ultrasound imaging system Vevo 770 for visualization of the radial artery and peripheral veins and acquired corresponding optoacoustic signals from them using the optoacoustic systems. Analysis of the optoacoustic data with a specially developed algorithm allowed for measurement of blood oxygenation in the blood vessels as well as for continuous, real-time monitoring of arterial and venous blood oxygenation. Our results indicate that: 1) the optoacoustic technique (unlike pure optical approaches and other noninvasive techniques) is capable of accurate peripheral venous oxygenation measurement; and 2) peripheral venous oxygenation is dependent on skin temperature and local hemodynamics. Moreover, we performed for the first time (to the best of our knowledge) a comparative study of optoacoustic arterial oximetry and a standard pulse oximeter in humans and demonstrated superior performance of the optoacoustic arterial oximeter, in particular at low blood flow.

  3. The first experience with LHC beam gas ionization monitor

    CERN Document Server

    Sapinski, M; Dehning, B; Guerrero, A; Patecki, M; Versteegen, R


    The Beam Gas Ionization Monitors (BGI) are used to measure beam emittance on LHC. This paper describes the detectors and their operation and discusses the issues met during the commissioning. It also discusses the various calibration procedures used to correct for non-uniformity of Multi-Channel plates and to correct the beam size for effects affecting the electron trajectory after ionization.

  4. Development and Remodeling of the Vertebrate Blood-Gas Barrier

    Directory of Open Access Journals (Sweden)

    Andrew Makanya


    Full Text Available During vertebrate development, the lung inaugurates as an endodermal bud from the primitive foregut. Dichotomous subdivision of the bud results in arborizing airways that form the prospective gas exchanging chambers, where a thin blood-gas barrier (BGB is established. In the mammalian lung, this proceeds through conversion of type II cells to type I cells, thinning, and elongation of the cells as well as extrusion of the lamellar bodies. Subsequent diminution of interstitial tissue and apposition of capillaries to the alveolar epithelium establish a thin BGB. In the noncompliant avian lung, attenuation proceeds through cell-cutting processes that result in remarkable thinning of the epithelial layer. A host of morphoregulatory molecules, including transcription factors such as Nkx2.1, GATA, HNF-3, and WNT5a; signaling molecules including FGF, BMP-4, Shh, and TFG-β and extracellular proteins and their receptors have been implicated. During normal physiological function, the BGB may be remodeled in response to alterations in transmural pressures in both blood capillaries and airspaces. Such changes are mitigated through rapid expression of the relevant genes for extracellular matrix proteins and growth factors. While an appreciable amount of information regarding molecular control has been documented in the mammalian lung, very little is available on the avian lung.

  5. Ultrasonic monitoring of droplets' evaporation: Application to human whole blood. (United States)

    Laux, D; Ferrandis, J Y; Brutin, D


    During a colloidal droplet evaporation, a sol-gel transition can be observed and is described by the desiccation time τD and the gelation time τG. These characteristic times, which can be linked to viscoelastic properties of the droplet and to its composition, are classically rated by analysis of mass droplet evolution during evaporation. Even if monitoring mass evolution versus time seems straightforward, this approach is very sensitive to environmental conditions (vibrations, air flow…) as mass has to be evaluated very accurately using ultra-sensitive weighing scales. In this study we investigated the potentialities of ultrasonic shear reflectometry to assess τD and τG in a simple and reliable manner. In order to validate this approach, our study has focused on blood droplets evaporation on which a great deal of work has recently been published. Desiccation and gelation times measured with shear ultrasonic reflectometry have been perfectly correlated to values obtained from mass versus time analysis. This ultrasonic method which is not very sensitive to environmental perturbations is therefore very interesting to monitor the drying of blood droplets in a simple manner and is more generally suitable for complex fluid droplets evaporation investigation.

  6. A multichannel bioimpedance monitor for full-body blood flow monitoring. (United States)

    Vondra, Vlastimil; Jurak, Pavel; Viscor, Ivo; Halamek, Josef; Leinveber, Pavel; Matejkova, Magdalena; Soukup, Ladislav


    The design, properties, and possible diagnostic contribution of a multichannel bioimpedance monitor (MBM) with three independent current sources are presented in this paper. The simultaneous measurement of bioimpedance at 18 locations (the main part of the body, legs, arms, and neck) provides completely new information, on the basis of which more precise haemodynamic parameters can be obtained. The application of the MBM during various haemodynamic stages, such as resting in a supine position, tilting, exercise stress, and various respiration manoeuvres, is demonstrated. Statistical analysis on a group of 34 healthy volunteers is presented for demonstration of blood flow monitoring by using the proposed method.

  7. Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns

    Directory of Open Access Journals (Sweden)

    Toshio Itoh


    Full Text Available Various volatile organic compounds (VOCs in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls, and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system. The prototype system analyzed exhaled breath samples from 101 volunteers (74 patients with lung cancer and 27 controls. The prototype system exhibited a level of performance similar to that of the gas condenser-GC/MS system for breath analysis.

  8. Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns. (United States)

    Itoh, Toshio; Miwa, Toshio; Tsuruta, Akihiro; Akamatsu, Takafumi; Izu, Noriya; Shin, Woosuck; Park, Jangchul; Hida, Toyoaki; Eda, Takeshi; Setoguchi, Yasuhiro


    Various volatile organic compounds (VOCs) in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS) for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls), and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system. The prototype system analyzed exhaled breath samples from 101 volunteers (74 patients with lung cancer and 27 controls). The prototype system exhibited a level of performance similar to that of the gas condenser-GC/MS system for breath analysis.

  9. Sixth hour transcutaneous bilirubin predicting significant hyperbilirubinemia in ABO incompatible neonates

    Institute of Scientific and Technical Information of China (English)

    Ramesh Y Bhat; Pavan CG Kumar


    Background: Neonates with ABO hemolytic disease are at greater risk for developing significant hyperbilirubinemia. We aimed to determine whether sixth hour transcutaneous bilirubin (TcB) could predict such a risk. Methods: TcB measurements were obtained at the 6th hour of life in blood group A or B neonates born to blood group O, rhesus factor compatible mothers. Subsequent hyperbilirubinemia was monitored and considered significant if a neonate required phototherapy/exchange transfusion. The predictive role of sixth hour TcB was estimated. Results: Of 144 ABO incompatible neonates, 41(OA, 24; O-B, 17) had significant hyperbilirubinemia. Mean sixth hour TcB was significantly higher among neonates who developed significant hyperbilirubinemia than those who did not (5.83±1.35 mg/dL vs. 3.65±0.96 mg/dL, P4 mg/dL had the highest sensitivity of 93.5% and >6 mg/dL had the highest specifi city of 99%. Area under receiver operating characteristic curve was 0.898. Conclusion: Sixth hour TcB predicts subsequent significant hyperbilirubinemia in ABO incompatible neonates.

  10. Silicon microring refractometric sensor for atmospheric CO(2) gas monitoring. (United States)

    Mi, Guangcan; Horvath, Cameron; Aktary, Mirwais; Van, Vien


    We report a silicon photonic refractometric CO(2) gas sensor operating at room temperature and capable of detecting CO(2) gas at atmospheric concentrations. The sensor uses a novel functional material layer based on a guanidine polymer derivative, which is shown to exhibit reversible refractive index change upon absorption and release of CO(2) gas molecules, and does not require the presence of humidity to operate. By functionalizing a silicon microring resonator with a thin layer of the polymer, we could detect CO(2) gas concentrations in the 0-500ppm range with a sensitivity of 6 × 10(-9) RIU/ppm and a detection limit of 20ppm. The microring transducer provides a potential integrated solution in the development of low-cost and compact CO(2) sensors that can be deployed as part of a sensor network for accurate environmental monitoring of greenhouse gases.

  11. Reactive intermediates in the gas phase generation and monitoring

    CERN Document Server

    Setser, D W


    Reactive Intermediates in the Gas Phase: Generation and Monitoring covers methods for reactive intermediates in the gas phase. The book discusses the generation and measurement of atom and radical concentrations in flow systems; the high temperature flow tubes, generation and measurement of refractory species; and the electronically excited long-lived states of atoms and diatomic molecules in flow systems. The text also describes the production and detection of reactive species with lasers in static systems; the production of small positive ions in a mass spectrometer; and the discharge-excite


    Directory of Open Access Journals (Sweden)

    S. Schlüter


    Full Text Available The spontaneous Raman scattering technique is an excellent tool for a quantitative analysis of multi-species gas mixtures. It is a noninvasive optical method for species identification and gas phase concentration measurement of all Raman active molecules, since the intensity of the species specific Raman signal is linearly dependent on the concentration. Applying a continuous wave (CW laser it typically takes a few seconds to capture a gas phase Raman spectrum at room temperature. Nevertheless in contrast to these advantages the weak Raman signal intensity is a major drawback. Thus, it is still challenging to detect gas phase Raman spectra in alow-pressure regime with a temporal resolution of only a few 100 ms. In this work a fully functional gas phase Raman system for measurements in the low-pressure regime (p ≥ 980 hPa (absolute is presented. It overcomes the drawback of a weak Raman signal by using a multipass cavity. A description of the sensor setup and of the multipass arrangement will be presented. Moreover the complete functionality of the sensor system will be demonstrated by measurements at an anesthesia simulator under clinical relevant conditions and in comparison to a conventional gas monitor.

  13. Blood Pressure Mobile Monitoring for Pregnant Woman Based Android System (United States)

    Supriyanti, Retno; Erfayanto, Uji; Ramadani, Yogi; Murdyantoro, Eko; Widodo, Haris B.


    Currently, at least 18,000 women die every year in Indonesia due to pregnancy or childbirth. It means that every half hour a woman dies due to pregnancy or childbirth. As a result, every year 36,000 children became orphans. The high maternal mortality rate was put Indonesia on top in ASEAN. The main causes of maternal mortality are high-risk pregnancy. Mothers who have diseases like high blood pressure, pre-eclampsia, diabetes, hyperthyroidism, and already over 40 years old and infectious diseases such as rubella, hepatitis and HIV can be factors that lead to high-risk pregnancy. This paper will discuss the development of a blood pressure monitoring device that is suitable for pregnant women. It is based on convenience for pregnant women to get the equipment that is flexible with her presence. Results indicate that the equipment is in use daily support for pregnant women therefore, one of the causes of maternal mortality can be detected earlier.

  14. Microfabricated BTU monitoring device for system-wide natural gas monitoring.

    Energy Technology Data Exchange (ETDEWEB)

    Einfeld, Wayne; Manginell, Ronald Paul; Robinson, Alex Lockwood; Moorman, Matthew Wallace


    The natural gas industry seeks inexpensive sensors and instrumentation to rapidly measure gas heating value in widely distributed locations. For gas pipelines, this will improve gas quality during transfer and blending, and will expedite accurate financial accounting. Industrial endusers will benefit through continuous feedback of physical gas properties to improve combustion efficiency during use. To meet this need, Sandia has developed a natural gas heating value monitoring instrument using existing and modified microfabricated components. The instrument consists of a silicon micro-fabricated gas chromatography column in conjunction with a catalytic micro-calorimeter sensor. A reference thermal conductivity sensor provides diagnostics and surety. This combination allows for continuous calorimetric determination with a 1 minute analysis time and 1.5 minute cycle time using air as a carrier gas. This system will find application at remote natural gas mining stations, pipeline switching and metering stations, turbine generators, and other industrial user sites. Microfabrication techniques will allow the analytical components to be manufactured in production quantities at a low per-unit cost.

  15. Mobile Personal Health System for Ambulatory Blood Pressure Monitoring

    Directory of Open Access Journals (Sweden)

    Luis J. Mena


    Full Text Available The ARVmobile v1.0 is a multiplatform mobile personal health monitor (PHM application for ambulatory blood pressure (ABP monitoring that has the potential to aid in the acquisition and analysis of detailed profile of ABP and heart rate (HR, improve the early detection and intervention of hypertension, and detect potential abnormal BP and HR levels for timely medical feedback. The PHM system consisted of ABP sensor to detect BP and HR signals and smartphone as receiver to collect the transmitted digital data and process them to provide immediate personalized information to the user. Android and Blackberry platforms were developed to detect and alert of potential abnormal values, offer friendly graphical user interface for elderly people, and provide feedback to professional healthcare providers via e-mail. ABP data were obtained from twenty-one healthy individuals (>51 years to test the utility of the PHM application. The ARVmobile v1.0 was able to reliably receive and process the ABP readings from the volunteers. The preliminary results demonstrate that the ARVmobile 1.0 application could be used to perform a detailed profile of ABP and HR in an ordinary daily life environment, bedsides of estimating potential diagnostic thresholds of abnormal BP variability measured as average real variability.

  16. High-Tech Blood Sugar Monitors May Help People with Type 1 Diabetes (United States)

    ... gov/news/fullstory_163211.html High-Tech Blood Sugar Monitors May Help People With Type 1 Diabetes ... need insulin shots every day manage their blood sugar levels safely, two new studies suggest. Also known ...

  17. Long-term monitoring of marine gas leakage (United States)

    Spickenbom, Kai; Faber, Eckhard; Poggenburg, Jürgen; Seeger, Christian; Furche, Markus


    The sequestration of CO2 in sub-seabed geological formations is one of the Carbon Capture and Storage (CCS) strategies currently under study. Although offshore operations are significantly more expensive than comparable onshore operations, the growing public resistance against onshore CCS projects makes sub-seabed storage a promising option. Even after a thorough review of the geological setting, there is always the possibility of leakage from the reservoir. As part of the EU-financed project CO2ReMoVe (Research, Monitoring, Verification), which aims to develop innovative research and technologies for monitoring and verification of carbon dioxide geological storage, we are working on the development of submarine long-term gas flow monitoring systems. The basic design of the monitoring system builds on our experience in volcano monitoring. Early prototypes were composed of a raft floating on the surface of a mud volcano, carrying sensors for CO2 flux and concentration, data storage and transmission, and power supply by battery-buffered solar panels. The system was modified for installation in open sea by using a buoy instead of a raft and a funnel on the seafloor to collect the gas, connected by a flexible tube. This setup provides a cost-effective solution for shallow waters. However, a buoy interferes with ship traffic, and it is also difficult to adapt this design to greater water depths. These requirements can best be complied by a completely submersed system. A system for unattended long-term monitoring in a marine environment has to be extremely durable. Therefore, we focussed on developing a mechanically and electrically as simple setup as possible, which has the additional advantage of low cost. The system consists of a funnel-shaped gas collector, a sensor head and pressure housings for electronics and power supply. Since this setup is inexpensive, it can be deployed in numbers to cover larger areas. By addition of multi-channel data loggers, data

  18. Long-term flow monitoring of submarine gas emanations (United States)

    Spickenbom, K.; Faber, E.; Poggenburg, J.; Seeger, C.


    One of the Carbon Capture and Storage (CCS) strategies currently under study is the sequestration of CO2 in sub-seabed geological formations. Even after a thorough review of the geological setting, there is the possibility of leaks from the reservoirs. As part of the EU-financed project CO2ReMoVe (Research, Monitoring, Verification), which aims to develop innovative research and technologies for monitoring and verification of carbon dioxide geological storage, we are working on the development of submarine long-term gas flow monitoring systems. Technically, however, these systems are not limited to CO2 but can be used for monitoring of any free gas emission (bubbles) on the seafloor. The basic design of the gas flow sensor system was derived from former prototypes developed for monitoring CO2 and CH4 on mud volcanoes in Azerbaijan. This design was composed of a raft floating on the surface above the gas vent to collect the bubbles. Sensors for CO2 flux and concentration and electronics for data storage and transmission were mounted on the raft, together with battery-buffered solar panels for power supply. The system was modified for installation in open sea by using a buoy instead of a raft and a funnel on the seafloor to collect the gas, which is then guided above water level through a flexible tube. Besides some technical problems (condensed water in the tube, movement of the buoys due to waves leading to biased measurement of flow rates), this setup provides a cost-effective solution for shallow waters. However, a buoy interferes with ship traffic, and it is also difficult to adapt this design to greater water depths. These requirements can best be complied by a completely submersed system. To allow unattended long-term monitoring in a submarine environment, such a system has to be extremely durable. Therefore, we focussed on developing a mechanically and electrically as simple setup as possible, which has the additional advantage of low cost. The system

  19. Transcutaneous immunization using microneedles and cubosomes

    DEFF Research Database (Denmark)

    Rattanapak, Teerawan; Birchall, James; Young, Katherine


    Transcutaneous (TCI) immunization is a novel vaccination approach that provides many advantages over traditional parenteral vaccination. However, a major barrier to TCI is mediating penetration of vaccine antigens through the stratum corneum (SC) to the deeper tissue layers. Many approaches have...

  20. Peripheral arterial blood pressure monitoring adequately tracks central arterial blood pressure in critically ill patients: an observational study


    Mignini, Mariano Alejandro; Piacentini, Enrique; Dubin,Arnaldo


    Introduction Invasive arterial blood pressure monitoring is a common practice in intensive care units (ICUs). Accuracy of invasive blood pressure monitoring is crucial in evaluating the cardiocirculatory system and adjusting drug therapy for hemodynamic support. However, the best site for catheter insertion is controversial. Lack of definitive information in critically ill patients makes it difficult to establish guidelines for daily practice in intensive care. We hypothesize that peripheral ...

  1. Antihypertensive effect of low-frequency transcutaneous electrical nerve stimulation (TENS) in comparison with drug treatment. (United States)

    Silverdal, Jonas; Mourtzinis, Georgios; Stener-Victorin, Elisabet; Mannheimer, Clas; Manhem, Karin


    Hypertension is a major risk factor for vascular disease, yet blood pressure (BP) control is unsatisfactory low, partly due to side-effects. Transcutaneous electrical nerve stimulation (TENS) is well tolerated and studies have demonstrated BP reduction. In this study, we compared the BP lowering effect of 2.5 mg felodipin once daily with 30 min of bidaily low-frequency TENS in 32 adult hypertensive subjects (mean office BP 152.7/90.0 mmHg) in a randomized, crossover design. Office BP and 24-h ambulatory BP monitoring (ABPM) were performed at baseline and at the end of each 4-week treatment and washout period. Felodipin reduced office BP by 10/6 mmHg (p TENS reduced office BP by 5/1.5 mmHg (p TENS washout, BP was further reduced and significantly lower than at baseline, but at levels similar to BP after felodipin washout and therefore reasonably caused by factors other than the treatment per se. ABPM revealed a significant systolic reduction of 3 mmHg by felodipin, but no significant changes were noted after TENS. We conclude that our study does not present any solid evidence of BP reduction of TENS.

  2. GasQuant-hydroacoustic monitoring of a natural gas seep field, Tommeliten, North Sea

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, J.; Von Deimling, J. [Leibniz Inst. for Baltic Sea Research, Rostock (Germany); Greinert, J. [Ghent Univ., Ghent (Belgium). Renard Centre of Marine Geology; Linke, P. [Leibniz Inst. of Marine Science, Kiel (Germany)


    Marine gas seeps can cause significant releases of greenhouse gases (GHGs) into the atmosphere. Gas bubbles rising up from the sea floor are thought to be strong indicators of underlying gas hydrates in sea floor sediments. This paper described a new tool developed to monitor gas bubbles. The GasQuant monitor was comprised of a multibeam system, a 180 kHz transducer and a data storage and computerized control system. The transducer was placed 3 meters above the sea floor. Its swath covered a range of between 13 and 63 meters. Received echo time series for the beams were divided into 512 samples. The system was adapted to sequentially scan the water column and correct backscatter for geometrical spreading and absorption. The study showed that the system accurately localized and analyzed bubble releases from the sea floor with a higher spatial and temporal resolution than other currently available optical systems. Sixty-one gas releasing point sources were identified within an area of 2075 m{sup 2}. Data obtained from the study showed that miscellaneous bubble release patterns occurred in close proximity to each other. Constant, tidal-dominated, periodic and erratic bubble release patterns co-existed a few meters apart from each other. Tidal and pressure effects accounted for 8 per cent of all gas releases from seep holes. The system will also be calibrated in order to enable gas flux estimates for seepage research. Bubble detection algorithms are now being designed to analyze data obtained from the system. 21 refs., 1 tab., 6 figs.

  3. Blood gas analysis in dogs with pulmonary heartworm disease. (United States)

    Kitagawa, H; Yasuda, K; Sasaki, Y


    Blood gases were analyzed in dogs with pulmonary heartworm (HW) disease. The arterial oxygen tension (PaO2) in dogs with mild signs of dirofilariasis (mildly affected group, n = 48, 85.7 +/- 8.2 mmHg) and in dogs with signs of right heart failure (severely affected group, n = 13, 76.4 +/- 11.6 mmHg) was lower (p < 0.01) than in dogs without HW infection (HW-free group, n = 19, 91.5 +/- 7.3 mmHg). Only 2 dogs in the severely affected group had a PaO2 less than 60 mmHg. The arterial carbon dioxide tension (PaCO2, p < 0.01) and mixed venous O2 (p < 0.01) and CO2 (p < 0.01) tensions were lower, and alveolar-arterial oxygen difference (AaDO2, p < 0.01) was greater in the severely affected group than in the HW-free and mildly affected groups. Arterial pH and bicarbonate (HCO3-) concentrations were lower (p < 0.01) in both affected groups than in the HW-free groups. The anion gap level was not different among the 3 groups. Serum lactic acid level in the severely affected group was higher (p < 0.01) than in the HW-free and mildly affected groups. However, a slightly higher serum lactic acid concentration was found only in 2 dogs of the severely affected group (3.84 mmol/l and 3.82 mmol/l). The PaO2 (r = -0.62) and AaDO2 (r = 0.66) correlated significantly (p < 0.01) with mean pulmonary arterial pressure. One week after HW removal, blood gases, pH and HCO3- concentration remained unchanged in the mildly affected group. In the severely affected group, blood gas values were the same, but pH and HCO3- concentration improved slightly.

  4. Accuracy of the Dinamap 1846 XT automated blood pressure monitor. (United States)

    Beaubien, E R; Card, C M; Card, S E; Biem, H J; Wilson, T W


    Accurate blood pressure (BP) measurement is important for the detection and treatment of hypertension. Despite widespread use of automated devices, there is limited published evidence for their reliability and accuracy. To determine the reliability and accuracy of the Dinamap 1846XT (Critikon Corporation, Tampa, FL, USA), a commonly used non-invasive oscillometric BP monitor The Dinamap was evaluated against the mercury manometer in 70 randomly selected adult hospitalised medical patients. Each individual underwent three sets of standardised BP measurement by automated method and three sets by mercury manometer by two independent observers. Reliability of BP measurement was assessed by repeated measures analysis. Dinamap accuracy was evaluated according to the American Association of Medical Instrumentation (AAMI) and British Hypertension Society (BHS) guidelines. Most patients were either normotensive or had stage I hypertension. The Dinamap tended to overestimate lower diastolic BP, and displayed poor reliability (P mercury manometer and 84% of systolic and 80% of diastolic readings were within 10 mm hg (bhs grade c). systolic and diastolic accuracy were worse with pressures >160/90 mm Hg (grade D) although these measures were based on a smaller sample of subjects. In conclusion the Dinamap yields inaccurate estimates of both systolic and diastolic BP even under standardised, and thus optimal conditions. This inaccuracy is exaggerated at higher BP (>160/90 mm Hg), although the number of measurements at higher pressures was small. We recommend that this device not be used when accurate BP measurement is needed for therapeutic decision-making.

  5. Evaluation of the Capillary Blood Glucose Self-monitoring Program

    Directory of Open Access Journals (Sweden)

    Mariana Cristina Augusto


    Full Text Available OBJECTIVE: to evaluate the structure, process and results of the Capillary Blood Glucose Self-monitoring Program in a Brazilian city.METHOD: epidemiological, cross-sectional study. The methodological framework of Donabedian was used to construct indicators of structure, process and outcome. A random sample (n = 288 of users enrolled and 96 health professionals who worked in the program was studied. Two questionnaires were used that were constructed for this study, one for professionals and one for users, both containing data for the evaluation of structure, process and outcome. Anthropometric measures and laboratory results were collected by consulting the patients' health records. The analysis involved descriptive statistics.RESULTS: most of the professionals were not qualified to work in the program and were not knowledgeable about the set of criteria for patient registration. None of the patients received complete and correct orientations about the program and the percentage with skills to perform conducts autonomously was 10%. As regards the result indicators, 86.4% of the patients and 81.3% of the professionals evaluated the program positively.CONCLUSION: the evaluation indicators designed revealed that one of the main objectives of the program, self-care skills, has not been achieved.

  6. Evaluation of the Capillary Blood Glucose Self-monitoring Program (United States)

    Augusto, Mariana Cristina; Nitsche, Maria José Trevizani; Parada, Cristina Maria Garcia de Lima; Zanetti, Maria Lúcia; Carvalhaes, Maria Antonieta de Barros Leite


    OBJECTIVE: to evaluate the structure, process and results of the Capillary Blood Glucose Self-monitoring Program in a Brazilian city. METHOD: epidemiological, cross-sectional study. The methodological framework of Donabedian was used to construct indicators of structure, process and outcome. A random sample (n = 288) of users enrolled and 96 health professionals who worked in the program was studied. Two questionnaires were used that were constructed for this study, one for professionals and one for users, both containing data for the evaluation of structure, process and outcome. Anthropometric measures and laboratory results were collected by consulting the patients' health records. The analysis involved descriptive statistics. RESULTS: most of the professionals were not qualified to work in the program and were not knowledgeable about the set of criteria for patient registration. None of the patients received complete and correct orientations about the program and the percentage with skills to perform conducts autonomously was 10%. As regards the result indicators, 86.4% of the patients and 81.3% of the professionals evaluated the program positively. CONCLUSION: the evaluation indicators designed revealed that one of the main objectives of the program, self-care skills, has not been achieved. PMID:25493676

  7. Dried blood spot analysis for therapeutic drug monitoring of pazopanib. (United States)

    de Wit, Djoeke; den Hartigh, Jan; Gelderblom, Hans; Qian, Yanwen; den Hollander, Margret; Verheul, Henk; Guchelaar, Henk-Jan; van Erp, Nielka P


    Dried blood spot (DBS) sampling is potentially a more patient-friendly and flexible alternative to venous sampling of pazopanib. This study determined the agreement between pazopanib DBS and plasma concentrations to facilitate implementation of pazopanib DBS sampling into clinical practice. Paired DBS and plasma samples were collected in 12 patients. Pazopanib plasma concentrations were calculated from DBS concentrations using the formula: plasma concentration = DBSconcentration /(1 - hematocrit). Passing-Bablok and Bland-Altman analyses were used to determine the agreement between calculated and measured plasma concentrations. We predefined a clinical acceptance limit of 25% for the Bland-Altman analysis. Passing-Bablok analysis showed a small constant (intercept estimate, -8.53 [95%CI, -12.22 to -4.41]) and slightly proportional (slope estimate, 1.15 [95%CI, 1.04-1.24]) bias between calculated and measured concentrations. This bias was clinically nonrelevant, as shown by Bland-Altman analysis; the mean ratio of calculated to measured concentrations was 0.94 (95%CI, 0.65-1.23). The clinical acceptance limits were well within these 95% limits of agreement. More specifically, 92.6% of the data points were within the predefined acceptance limits. Pazopanib plasma concentrations can be accurately calculated from DBS concentrations. Although validation of DBS cards prepared by patients themselves is required, these results show that DBS sampling can be used to monitor pazopanib therapy in clinical practice.

  8. Mucosal blood flow measurements using laser Doppler perfusion monitoring

    Institute of Scientific and Technical Information of China (English)

    Dag Arne Lihaug Hoff; Hans Gregersen; Jan Gunnar Hatlebakk


    Perfusion of individual tissues is a basic physiological process that is necessary to sustain oxygenation and nutrition at a cellular level. Ischemia, or the insufficiency of perfusion, is a common mechanism for tissue death or degeneration, and at a lower threshold, a mechanism for the generation of sensory signalling including pain. It is of considerable interest to study perfusion of peripheral abdominal tissues in a variety of circumstances. Microvascular disease of the abdominal organs has been implicated in the pathogenesis of a variety of disorders, including peptic ulcer disease, inflammatory bowel disease and chest pain. The basic principle of laser Doppler perfusion monitoring (LDPM) is to analyze changes in the spectrum of light reflected from tissues as a response to a beam of monochromatic laser light emitted. It reflects the total local microcirculatory blood perfusion, including perfusion in capillaries, arterioles, venules and shunts. During the last 20-25 years, numerous studies have been performed in different parts of the gastrointestinal (GI) tract using LDPM. In recent years we have developed a multi-modal catheter device which includes a laser Doppler probe, with the intent primarily to investigate patients suffering from functional chest pain of presumed oesophageal origin. Preliminary studies show the feasibility of incorporating LDPM into such catheters for performing physiological studies in the GI tract. LDPM has emerged as a research and clinical tool in preference to other methods; but, it is important to be aware of its limitations and account for them when reporting results.

  9. Active Geophysical Monitoring in Oil and Gas Industry (United States)

    Bakulin, A.; Calvert, R.


    Effective reservoir management is a Holy Grail of the oil and gas industry. Quest for new technologies is never ending but most often they increase effectiveness and decrease the costs. None of the newcomers proved to be a silver bullet in such a key metric of the industry as average oil recovery factor. This factor is still around 30 %, meaning that 70 % of hydrocarbon reserves are left in the ground in places where we already have expensive infrastructure (platforms, wells) to extract them. Main reason for this inefficiency is our inability to address realistic reservoir complexity. Most of the time we fail to properly characterize our reservoirs before production. As a matter of fact, one of the most important parameters -- permeability -- can not be mapped from remote geophysical methods. Therefore we always start production blind even though reservoir state before production is the simplest one. Once first oil is produced, we greatly complicate the things and quickly become unable to estimate the state and condition of the reservoir (fluid, pressures, faults etc) or oilfield hardware (wells, platforms, pumps) to make a sound next decision in the chain of reservoir management. Our modeling capabilities are such that if we know true state of the things - we can make incredibly accurate predictions and make extremely efficient decisions. Thus the bottleneck is our inability to properly describe the state of the reservoirs in real time. Industry is starting to recognize active monitoring as an answer to this critical issue. We will highlight industry strides in active geophysical monitoring from well to reservoir scale. It is worth noting that when one says ``monitoring" production technologists think of measuring pressures at the wellhead or at the pump, reservoir engineers think of measuring extracted volumes and pressures, while geophysicist may think of change in elastic properties. We prefer to think of monitoring as to measuring those parameters of the

  10. Beam Impedance Studies of the PS Beam Gas Ionization Monitor

    CERN Document Server

    Avgidis, Fotios


    The Beam Gas Ionization monitor (BGI) is a device for continuous beam size monitoring that is intended to be installed in the CERN Proton Synchrotron (PS) during the extended year-end technical stop from December 2016 to April 2017. With the objective of determining the impedance contribution of the BGI vacuum chamber to the overall beam impedance, we report on RF measurements on the device in a laboratory frame, measurement data analysis, and RF simulations of the structure under investigation. For the impedance contribution characterization of the BGI, the following approach has been followed: First, the EM fields inside a simplified BGI model that doesn’t include any of the internal components of the vacuum chamber have been simulated. RF measurements have been performed on the same empty structure showing great agreement between measurement and simulation and thus verifying the validity of the model. Second, simulations have been executed on a fully assembled BGI model that includes all the internal ele...

  11. Laser Spectroscopy Based Multi-Gas Monitor Technology Demonstration (United States)

    Mudgett, Paul D.; Pilgrim, Jeffrey S.


    The timing was right in the “evolution” of low power tunable diode laser spectroscopy (TDLS) to design a spacecraft cabin air monitor around technology being developed at a small company funded by SBIR grants. NASA Centers had been monitoring their progress hoping that certain key gaps in the long term gas monitoring development roadmap could be filled by TDLS. The first iteration of a monitor for multiple gases called the Multi-Gas Monitor (MGM) which measures oxygen, carbon dioxide, ammonia and water vapor, as well as temperature and pressure. In January 2013, the ISS Program being particularly interested in ammonia funded a technology demonstration of MGM. The project was a joint effort between Vista Photonics for the sensor, NASA-JSC for project management and laboratory calibration, and Nanoracks for the enclosure and payload certification/integration. Nanoracks was selected in order to use their new experimental infrastructure located in an EXPRESS rack in the JEM. The MGM enclosure has multiple power supply options including 5VDC USB interface to the Nanoracks Frame, 28VDC Express Rack power and internal rechargeable batteries. MGM was calibrated at NASA-JSC in July 2013, delivered to ISS on 37 Soyuz in November 2013 and was installed and activated in February 2014. MGM resided in the Nanoracks Frame making continuous measurements the majority of the time, but also spent a day in Node 3 on battery power, and a month in the US Lab Module on 28VDC power, as part of the demonstration. Data was downloaded via Nanoracks on roughly a weekly basis. Comparisons were made with data from the Major Constituents Analyzer (MCA) which draws and analyzes air from JEM and other modules several times per hour. A crewmember challenged the carbon dioxide channel by breathing into the intake upon startup, and challenged the ammonia channel later using a commercial ammonia inhalant. Many interesting phenomena in the cabin atmosphere were detected during the tech demo

  12. European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring

    NARCIS (Netherlands)

    Parati, Gianfranco; Stergiou, George; O'Brien, Eoin; Asmar, Roland; Beilin, Lawrence; Bilo, Grzegorz; Clement, Denis; de la Sierra, Alejandro; de Leeuw, Peter; Dolan, Eamon; Fagard, Robert; Graves, John; Head, Geoffrey A; Imai, Yutaka; Kario, Kazuomi; Lurbe, Empar; Mallion, Jean-Michel; Mancia, Giuseppe; Mengden, Thomas; Myers, Martin; Ogedegbe, Gbenga; Ohkubo, Takayoshi; Omboni, Stefano; Palatini, Paolo; Redon, Josep; Ruilope, Luis M; Shennan, Andrew; Staessen, Jan A; vanMontfrans, Gert; Verdecchia, Paolo; Waeber, Bernard; Wang, Jiguang; Zanchetti, Alberto; Zhang, Yuqing


    Given the increasing use of ambulatory blood pressure monitoring (ABPM) in both clinical practice and hypertension research, a group of scientists, participating in the European Society of Hypertension Working Group on blood pressure monitoring and cardiovascular variability, in year 2013 published

  13. Development of monitoring and control technology based on trace gas monitoring. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Liebowitz, B.


    Trace gases are generated by many biological reactions. During anaerobic decomposition, trace levels of hydrogen (H{sub 2}) and carbon monoxide (CO) gases are produced. It was shown previously that these trace gases are intrinsically related to the biochemical reactions occurring and, therefore, offer promise for on-line process monitoring and control. This work was designed to test how effectively hydrogen and CO could be to monitor high-rate anaerobic systems that has significant mass transfer and complex hydraulics. An experimental program was designed to examine the behavior of an upflow anaerobic sludge blanket (UASB) reactor system under steady state and in response to organic loading perturbations. The responses of trace gases CO and H{sub 2} were tracked using an on-line, real-time gas-monitoring system linked to a computer-controlled data acquisition package. Data on conventional process parameters such as pH, chemical oxygen demand (COD), volatile fatty acids (VFAs) were concurrently collected. Monitoring of conventional process indicators (i.e., pH, VFA, gas production) and trace gas (H{sub 2} and CO) indicators was conducted using a matrix of nine different steady-state OLRs (4-23 kg COD/m{sup 3} -d) and system HRTs (0.5 to 2.5 days) was performed to determine any correlation among the indicators. Of OLR, HRT, and influent COD, only OLR had any significant influence on the process indicators examined. All parameters except methane increased with increases in OLR; methane decreased with increased OLR. The OLR and gas production rate (GP) were observed to be linearly correlated.

  14. Diabetes and Exercise: When to Monitor Your Blood Sugar (United States)

    ... plan. To avoid potential problems, check your blood sugar before, during and after exercise. By Mayo Clinic ... diabetes. Exercise can help you improve your blood sugar control, boost your overall fitness, and reduce your ...

  15. Transcutaneous bilirubin nomograms in African neonates (United States)

    Mabogunje, Cecilia A.; Imosemi, Donald O.; Emokpae, Abieyuwa A.


    Background The use of transcutaneous bilirubin (TcB) as a screening tool, based on relevant population-specific nomogram, or proxy for total serum bilirubin (TSB) levels in assessing the risk of subsequent hyperbilirubinemia is supported by several clinical guidelines on the management of neonatal hyperbilirubinemia. However, while TcB has been found to significantly over-estimate TSB in neonates of African-American ancestry, with variations across TcB devices, no nomogram has been specifically reported for this racial group. This study therefore set out to develop TcB nomograms for healthy late pre-term and term black African neonates derived from two widely used bilirubinometers. Methods A retrospective analysis of 12,377 TcB measurements obtained from 6,373 neonates in the first postnatal week, over a period of 48 months using Bilichek and JM-103 bilirubinometers. TcB percentiles were computed from hour-specific TcB values and nomograms developed for each of the screening devices. Predictive ability of the 75th and 95th percentiles to detect significant hyperbilirubinemia was evaluated between 24–96 hours of age. The 95th percentile curve was compared with those from other populations. Results The velocity of TcB rise at 75th and 95th percentiles was generally higher with JM-103 than Bilichek. Both percentiles also peaked at higher TcB levels with JM-103. The 95th percentile for both instruments showed a downward trend as from approximately 114 hours. Both instruments had high negative predictive values across the selected time-epochs and lower discriminatory ability than reported in non-black populations. Conclusions The predictive utility of TcB as a potential screening tool varies across devices in black African neonates with or without risk of significant hyperbilirubinemia, and lower than levels reported in non-black populations. Equipment-specific nomograms should be considered for TcB monitoring in this racial population where TSB is not routinely

  16. Fluid input control in burned patients with the aid of ultrasonic arterial blood pressure monitoring. (United States)

    Banssillon, V; Latarjet, J


    Arterial blood pressure is nowadays easily and reliably measured with ultrasonic equipment. It correlates well with blood volume, and may therefore be used to guide fluid infusion in burned patients. Monitoring of blood pressure, instead of application of old-fashioned recipes, helps to avoid dangerous situations of hypovolemia or overload.

  17. Metal Oxide Semi-Conductor Gas Sensors in Environmental Monitoring

    Directory of Open Access Journals (Sweden)

    George F. Fine


    Full Text Available Metal oxide semiconductor gas sensors are utilised in a variety of different roles and industries. They are relatively inexpensive compared to other sensing technologies, robust, lightweight, long lasting and benefit from high material sensitivity and quick response times. They have been used extensively to measure and monitor trace amounts of environmentally important gases such as carbon monoxide and nitrogen dioxide. In this review the nature of the gas response and how it is fundamentally linked to surface structure is explored. Synthetic routes to metal oxide semiconductor gas sensors are also discussed and related to their affect on surface structure. An overview of important contributions and recent advances are discussed for the use of metal oxide semiconductor sensors for the detection of a variety of gases—CO, NOx, NH3 and the particularly challenging case of CO2. Finally a description of recent advances in work completed at University College London is presented including the use of selective zeolites layers, new perovskite type materials and an innovative chemical vapour deposition approach to film deposition.

  18. Condition Based Monitoring of Gas Turbine Combustion Components

    Energy Technology Data Exchange (ETDEWEB)

    Ulerich, Nancy; Kidane, Getnet; Spiegelberg, Christine; Tevs, Nikolai


    The objective of this program is to develop sensors that allow condition based monitoring of critical combustion parts of gas turbines. Siemens teamed with innovative, small companies that were developing sensor concepts that could monitor wearing and cracking of hot turbine parts. A magnetic crack monitoring sensor concept developed by JENTEK Sensors, Inc. was evaluated in laboratory tests. Designs for engine application were evaluated. The inability to develop a robust lead wire to transmit the signal long distances resulted in a discontinuation of this concept. An optical wear sensor concept proposed by K Sciences GP, LLC was tested in proof-of concept testing. The sensor concept depended, however, on optical fiber tips wearing with the loaded part. The fiber tip wear resulted in too much optical input variability; the sensor could not provide adequate stability for measurement. Siemens developed an alternative optical wear sensor approach that used a commercial PHILTEC, Inc. optical gap sensor with an optical spacer to remove fibers from the wearing surface. The gap sensor measured the length of the wearing spacer to follow loaded part wear. This optical wear sensor was developed to a Technology Readiness Level (TRL) of 5. It was validated in lab tests and installed on a floating transition seal in an F-Class gas turbine. Laboratory tests indicate that the concept can measure wear on loaded parts at temperatures up to 800{degrees}C with uncertainty of < 0.3 mm. Testing in an F-Class engine installation showed that the optical spacer wore with the wearing part. The electro-optics box located outside the engine enclosure survived the engine enclosure environment. The fiber optic cable and the optical spacer, however, both degraded after about 100 operating hours, impacting the signal analysis.

  19. Wearable Beat to Beat Blood Pressure Monitor Project (United States)

    National Aeronautics and Space Administration — A key component of NASA's human exploration programs is a system that monitors the health of the crew during the space missions. The wearable physiological monitor...

  20. Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O(2) carrying capacity. (United States)

    Rissanen, Antti-Pekka E; Tikkanen, Heikki O; Koponen, Anne S; Aho, Jyrki M; Hägglund, Harriet; Lindholm, Harri; Peltonen, Juha E


    The magnitude and timing of oxygenation responses in highly active leg muscle, less active arm muscle, and cerebral tissue, have not been studied with simultaneous alveolar gas exchange measurement during incremental treadmill exercise. Nor is it known, if blood O(2) carrying capacity affects the tissue-specific oxygenation responses. Thus, we investigated alveolar gas exchange and tissue (m. vastus lateralis, m. biceps brachii, cerebral cortex) oxygenation during incremental treadmill exercise until volitional fatigue, and their associations with blood O(2) carrying capacity in 22 healthy men. Alveolar gas exchange was measured, and near-infrared spectroscopy (NIRS) was used to monitor relative concentration changes in oxy- (Δ[O(2)Hb]), deoxy- (Δ[HHb]) and total hemoglobin (Δ[tHb]), and tissue saturation index (TSI). NIRS inflection points (NIP), reflecting changes in tissue-specific oxygenation, were determined and their coincidence with ventilatory thresholds [anaerobic threshold (AT), respiratory compensation point (RC); V-slope method] was examined. Blood O(2) carrying capacity [total hemoglobin mass (tHb-mass)] was determined with the CO-rebreathing method. In all tissues, NIPs coincided with AT, whereas RC was followed by NIPs. High tHb-mass associated with leg muscle deoxygenation at peak exercise (e.g., Δ[HHb] from baseline walking to peak exercise vs. tHb-mass: r = 0.64, p capacity for blood O(2) carrying was associated with a high level of m. vastus lateralis deoxygenation at peak exercise.

  1. Transcutaneous absorption of oil in preterm babies--a pilot study. (United States)

    Fernandez, A R; Krishnamoorthy, G; Patil, N; Mondkar, J A; Swar, B D


    This study was conducted to determine transcutaneous absorption of oil in preterm neonates. A mixture of coconut oil and Meadowfoam oil which contains unique fatty acids, which acted as marker fatty acids was applied to the skin of babies. One mL blood was collected before and one hour after post oil application. Both pre and post oil application serum samples were hydrolysed and derivatised with 2-phenyl hydrazine hydrochloride in order to detect fatty acids by HPLC analysis on C-8 column. None of the pre oil application serum sample showed the presence of the marker fatty acids. The post oil application serum sample of all the 12 babies showed the presence of marker fatty acids of Meadowfoam oil which indicates transcutaneous absorption of oil in preterm babies.

  2. Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs

    Directory of Open Access Journals (Sweden)

    Charton A


    Full Text Available Antoine Charton,1 François Péronnet,2 Stephane Doutreleau,3 Evelyne Lonsdorfer,3 Alexis Klein,4 Liliana Jimenez,4 Bernard Geny,3 Pierre Diemunsch,1 Ruddy Richard5 1Department of Anesthesia and Critical Care, and EA 3072, Hôpital de Hautepierre; University of Strasbourg, Strasbourg, France; 2Department of Kinesiology, Université de Montréal, Montreal, QC, Canada; 3CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France and University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, France; 4Danone Research, Palaiseau, France; 5Department of Sport Medicine and Functional Explorations, CHU Clermont-Ferrand and INRA UMR 1019, CRNH-Auvergne, Clermont-Ferrand, France Background: Oral administration of oxygenated water has been shown to improve blood oxygenation and could be an alternate way for oxygen (O2 supply. In this experiment, tissue oxygenation was compared in anesthetized pigs receiving a placebo or water enriched in O2 by injection or a new electrolytic process. Methods: Forty-two pigs randomized in three groups received either mineral water as placebo or water enriched in O2 by injection or the electrolytic process (10 mL/kg in the stomach. Hemodynamic parameters, partial pressure of oxygen in the arterial blood (PaO2, skin blood flow, and tissue oxygenation (transcutaneous oxygen pressure, or TcPO2 were monitored during 90 minutes of general anesthesia. Absorption and tissue distribution of the three waters administered were assessed using dilution of deuterium oxide. Results: Mean arterial pressure, heart rate, PaO2, arteriovenous oxygen difference, and water absorption from the gut were not significantly different among the three groups. The deuterium to protium ratio was also similar in the plasma, skin, and muscle at the end of the protocol. Skin blood flow decreased in the three groups. TcPO2 slowly decreased over the last 60 minutes of the experiment in

  3. Monitoring carbon dioxide in mechanically ventilated patients during hyperbaric treatment

    DEFF Research Database (Denmark)

    Bjerregård, Asger; Jansen, Erik


    Measurement of the arterial carbon dioxide (P(a)CO(2)) is an established part of the monitoring of mechanically ventilated patients. Other ways to get information about carbon dioxide in the patient are measurement of end-tidal carbon dioxide (P(ET)CO(2)) and transcutaneous carbon dioxide (PTCCO2......). Carbon dioxide in the blood and cerebral tissue has great influence on vasoactivity and thereby blood volume of the brain. We have found no studies on the correlation between P(ET)CO(2) or P(TC)CO(2), and P(a)CO(2) during hyperbaric oxygen therapy (HBOT)....

  4. Trace gas detection and monitoring with the Digital Array Gas-correlation Radiometer (DAGR) (United States)

    Gordley, Larry L.; Hervig, Mark E.; Fish, Chad; McHugh, Martin J.


    We present the first results from a Digital Array Gas-correlation Radiometer (DAGR) prototype sensor, and discuss applications in remote sensing of trace gases. The sensor concept is based on traditional and reliable Gas Filter Correlation Radiometry (GFCR), but overcomes the limitations in solar backscatter applications. The DAGR sensor design can be scaled to the size of a digital camera and is ideal for downlooking detection of gases in the boundary layer, where solar backscatter measurements are needed to overcome the lack of thermal contrast in the IR. Ground-based portable DAGR sensors can monitor carbon sequestration sites or industrial facilities. Aircraft or UAV deployment can quickly survey large areas and are particularly well suited for gas leak detection or carbon monitoring. From space-based platforms, Doppler modulation can be exploited to produce an extremely fine spectral resolution with effective resolving power exceeding 100,000. Such space-based DAGR observations could provide near-global sensing of climatically important species such as such as CO2, CO, CH4, O3 and N2O. Planetary science applications include detection and mapping of biomarkers in the Martian atmosphere.

  5. Extensive monitoring through multiple blood samples in professional soccer players

    DEFF Research Database (Denmark)

    Heisterberg, Mette F; Fahrenkrug, Jan; Krustrup, Peter


    ABSTRACT: The aim of this study was to make a comprehensive gathering of consecutive detailed blood samples from professional soccer players, and to analyze different blood parameters in relation to seasonal changes in training and match exposure.Blood samples were collected five times during a six...... months period and analyzed for 37 variables in 27 professional soccer players from the best Danish league. Additionally, players were tested for body composition, VO2max and physical performance by the Yo-Yo intermittent endurance sub-max test (IE2).Multiple variations in blood parameters occurred during...... of the season. Leucocytes decreased with increased physical training. Lymphocytes decreased at the end of the season. VO2max decreased towards the end of the season whereas no significant changes were observed in the IE2 test.The regular blood samples from elite soccer players reveal significant changes...

  6. Development and Evaluation of a Hyperbaric Toxic Gas Monitor (SUBTOX) for Disabled Submarines (United States)



  7. Data Of Daily Blood Pressure Monitoring In Patients With Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    A.P. Rebrov


    Full Text Available The aim of present work is to study the frequency of hypertension and the peculiarity of 24-hour blood pressure monitoring in patients with rheumatoid arthritis. We studied 584 patients with rheumatoid arthritis. Daily blood pressure monitoring was carried out in 46 patients with arthritis and 18 patients with essential hypertension. Frequency of hypertension was higher in patients with arthritis then in general population. Elevation of systolic blood pressure, heart rate and arterial blood pressure adequate decrease at night were developed to associate with advance of the disease.

  8. Transcutaneous delivery of levodopa: enhancement by fatty acid synthesis inhibition. (United States)

    Babita, Kumar; Tiwary, Ashok K


    The present investigation aimed at evaluating the role of fatty acid synthesis inhibition in enhancing transcutaneous delivery of levodopa (LD). Rat epidermis was treated with ethanol and various doses of cerulenin (an inhibitor of fatty acid synthase enzyme system) for reducing the normal level of fatty acids. Calcium chloride (0.1 mM) and/or verapamil (1 microM) were coapplied to cerulenin treated skin in order to modulate duration of epidermal perturbation. These treated skin portions were used for estimation of altered triglyceride content (an indicator of fatty acid synthesis), differential scanning calorimetry (DSC) analysis, and in vitro permeation of LD. Plasma concentration of LD was monitored in rats following topical application of various transdermal formulations. Application of cerulenin (0.1 or 0.15 mM/7 cm(2)) to viable rat skin inhibited approximately 60% triglyceride synthesis with respect to control at 2 h. Coapplication of calcium chloride (0.1 mM) significantly increased this inhibition, whereas verapamil application reduced this effect. The decrease in triglyceride content reduced the enthalpy of the lipid endothermic transition. The in vitro permeation of LD was enhanced 3-fold across skin excised after treatment with cerulenin. LD did not permeate across normal skin. The effective plasma concentration (C(eff)) of LD was achieved within 3 h and maintained till 10 h by a single topical application of a carbidopa-levodopa combination (1:4) to ethanol-perturbed cerulenin-treated skin. Coapplication of calcium chloride reduced the time lag to achieve C(eff) to 2 h and maintained it till 24 h. A single transdermal LD (64 mg) patch formulated with calcium chloride (0.1 mM) and cerulenin (0.1 mM) dissolved in a propylene glycol:ethanol (7:3) mixture seems to offer a noninvasive approach for transcutaneous delivery of levodopa.


    NARCIS (Netherlands)



    Transcutaneous nerve stimulation (TENS) has been described as resulting in vasodilatation. The effect of 2 Hz TENS of the right hand during forty-five minutes on skin temperature and plethysmography of the third digit of both hands and feet and on transcutaneous oxygen tension (TcpO2) of the right h

  10. Gas Analysis and Monitoring Systems for the RPC Detector of CMS at LHC

    CERN Document Server

    Abbrescia, M; Guida, R; Iaselli, G; Liuzzi, R; Loddo, F; Maggi, M; Marangelli, B; Natali, S; Nuzzo, S; Pugliese, G; Ranieri, A; Romano, F; Trentadue, R; Benussi, L; Bertani, M; Bianco, S; Caponero, M A; Colonna, D; Donisi, D; Fabbri, F L; Felli, F; Ortenzi, M G B; Pallotta, M; Paolozzi, A; Passamonti, L; Ponzio, B; Pucci, C; Polese, G S G; Segoni, I; Cavallo, N; Fabozzi, F; Paolucci, P; Piccolo, D; Belli, C S G; Grelli, A; Necchi, M; Ratti, S P; Riccardi, C; Torre, P; Vitulo, P


    The Resistive Plate Chambers (RPC) detector of the CMS experiment at the LHC proton collider (CERN, Switzerland) will employ an online gas analysis and monitoring system of the freon-based gas mixture used. We give an overview of the CMS RPC gas system, describe the project parameters and first results on gas-chromatograph analysis. Finally, we report on preliminary results for a set of monitor RPC.

  11. The effect of transcutaneous application of carbon dioxide (CO{sub 2}) on skeletal muscle

    Energy Technology Data Exchange (ETDEWEB)

    Oe, Keisuke [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe (Japan); Ueha, Takeshi [NeoChemir Inc, Kobe (Japan); Sakai, Yoshitada, E-mail: [Faculty of Health Care Sciences, Himeji Dokkyo University, Himeji (Japan); Niikura, Takahiro; Lee, Sang Yang; Koh, Akihiro [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe (Japan); Hasegawa, Takumi [Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe (Japan); Tanaka, Masaya [NeoChemir Inc, Kobe (Japan); Miwa, Masahiko; Kurosaka, Masahiro [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe (Japan)


    Highlights: {yields} PGC-1{alpha} is up-regulated as a result of exercise such as mitochondrial biogenesis and muscle fiber-type switching, and up-regulation of VEGF. {yields} We demonstrated transcutaneous application of CO{sub 2} up-regulated the gene expression of PGC-1{alpha}, SIRT1 and VEGF, and instance of muscle fiber switching. {yields} Transcutaneous application of CO{sub 2} may cause similar effect to aerobic exercise in skeletal muscle. -- Abstract: In Europe, carbon dioxide therapy has been used for cardiac disease and skin problems for a long time. However there have been few reports investigating the effects of carbon dioxide therapy on skeletal muscle. Peroxisome proliferators-activated receptor (PPAR)-gamma coactivator-1 (PGC-1{alpha}) is up-regulated as a result of exercise and mediates known responses to exercise, such as mitochondrial biogenesis and muscle fiber-type switching, and neovascularization via up-regulation of vascular endothelial growth factor (VEGF). It is also known that silent mating type information regulation 2 homologs 1 (SIRT1) enhances PGC-1{alpha}-mediated muscle fiber-type switching. Previously, we demonstrated transcutaneous application of CO{sub 2} increased blood flow and a partial increase of O{sub 2} pressure in the local tissue known as the Bohr effect. In this study, we transcutaneously applied CO{sub 2} to the lower limbs of rats, and investigated the effect on the fast muscle, tibialis anterior (TA) muscle. The transcutaneous CO{sub 2} application caused: (1) the gene expression of PGC-1{alpha}, silent mating type information regulation 2 homologs 1 (SIRT1) and VEGF, and increased the number of mitochondria, as proven by real-time PCR and immunohistochemistry, (2) muscle fiber switching in the TA muscle, as proven by isolation of myosin heavy chain and ATPase staining. Our results suggest the transcutaneous application of CO{sub 2} may have therapeutic potential for muscular strength recovery resulting from disuse

  12. Upgrade to the Cryogenic Hydrogen Gas Target Monitoring System (United States)

    Slater, Michael; Tribble, Robert


    The cryogenic hydrogen gas target at Texas A&M is a vital component for creating a secondary radioactive beam that is then used in experiments in the Momentum Achromat Recoil Spectrometer (MARS). A stable beam from the K500 superconducting cyclotron enters the gas cell and some incident particles are transmuted by a nuclear reaction into a radioactive beam, which are separated from the primary beam and used in MARS experiments. The pressure in the target chamber is monitored so that a predictable isotope production rate can be assured. A ``black box'' received the analog pressure data and sent RS232 serial data through an outdated serial connection to an outdated Visual Basic 6 (VB6) program, which plotted the chamber pressure continuously. The black box has been upgraded to an Arduino UNO microcontroller [Atmel Inc.], which can receive the pressure data and output via USB to a computer. It has been programmed to also accept temperature data for future upgrade. A new computer program, with updated capabilities, has been written in Python. The software can send email alerts, create audible alarms through the Arduino, and plot pressure and temperature. The program has been designed to better fit the needs of the users. Funded by DOE and NSF-REU Program.

  13. Optical sensor technology for a noninvasive continuous monitoring of blood components (United States)

    Kraitl, Jens; Timm, Ulrich; Lewis, Elfed; Ewald, Hartmut


    NIR-spectroscopy and Photoplethysmography (PPG) is used for a measurement of blood components. The absorptioncoefficient of blood differs at different wavelengths. This fact is used to calculate the optical absorbability characteristics of blood which is yielding information about blood components like hemoglobin (Hb), carboxyhemoglobin (CoHb) and arterial oxygen saturation (SpO2). The measured PPG time signals and the ratio between the peak to peak pulse amplitudes are used for a measurement of these parameters. Hemoglobin is the main component of red blood cells. The primary function of Hb is the transport of oxygen from the lungs to the tissue and carbon dioxide back to the lungs. The Hb concentration in human blood is an important parameter in evaluating the physiological status of an individual and an essential parameter in every blood count. Currently, invasive methods are used to measure the Hb concentration, whereby blood is taken from the patient and subsequently analyzed. Apart from the discomfort of drawing blood samples, an added disadvantage of this method is the delay between the blood collection and its analysis, which does not allow real time patient monitoring in critical situations. A noninvasive method allows pain free continuous on-line patient monitoring with minimum risk of infection and facilitates real time data monitoring allowing immediate clinical reaction to the measured data.

  14. Two methods for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations

    DEFF Research Database (Denmark)

    Kanno, I; Lassen, N A


    Two methods are described for calculation of regional cerebral blood flow from completed tomographic data of radioactive inert gas distribution in a slice of brain tissue. It is assumed that the tomographic picture gives the average inert gas concentration in each pixel over data collection periods...

  15. Get the Most Out of Home Blood Pressure Monitoring (United States)

    ... monitors might not give you an accurate reading. Most pharmacies, medical supply stores and some websites sell ... fitted on the upper arm are generally the most accurate. If you can't find a cuff ...

  16. Blood gas analyzer utility in evaluating oxygen kinetics of the aqueous humor

    Directory of Open Access Journals (Sweden)

    Ismail Ersan


    Full Text Available Purpose: To measure the partial pressure of oxygen (PO2 and carbon dioxide (PCO2 and the pH of aqueous humor (AH and arterial blood samples from rabbits using a blood gas analyzer. Methods: Twenty New Zealand rabbits were anesthetized intramuscularly with ketamine and xylazine and were then allowed to breathe room air. Using a gas blood analyzer, arterial blood and AH samples were analyzed for PO2, PCO2, and pH. Results: The mean arterial blood pressure was 87.14 ± 15.0 mmHg. The mean blood and AH PO2 were 95.18 ± 11.76 mmHg and 88.83 ± 9.92 mmHg, the mean blood and AH PCO2 were 25.86 ± 5.46 mmHg and 29.50 ± 5.36 mmHg, and the mean blood and AH pH were 7.38 ± 0.06 and 7.33 ± 0.09, respectively. Conclusion: Conclusions: The blood gas analyzer was easily employed to evaluate the aqueous humor in rabbits. When comparing the results of studies evaluating aqueous PO2, care should be taken to determine the methods used in these studies.

  17. Evaluation of two methods of rapid blood-glucose monitoring by unskilled personnel during surgery

    DEFF Research Database (Denmark)

    Madsbad, S; Adelhøj, B; Bigler, Dennis Richard;


    The accuracy of two rapid methods of blood-glucose monitoring without (Haemo-glucotest 1-44) and with a reflectance meter (Hypocount B) was compared using a laboratory method. The assessment was carried out by personnel with no previous experience in measuring blood glucose. Eighty-five percent o...

  18. Novel Approach for Ensuring Increased Validity in Home Blood Pressure Monitoring

    DEFF Research Database (Denmark)

    Wagner, Stefan Rahr; Toftegaard, Thomas Skjødeberg; Bertelsen, Olav Wedege

    This paper proposes a novel technique to increase the validity of home blood pressure monitoring by using various sensor technologies as part of an intelligent environment platform in the home of the user. A range of recommendations exists on how to obtain a valid blood pressure...

  19. Self-Monitoring of Blood Glucose : Professional Advice and Daily Practice of Patients With Diabetes

    NARCIS (Netherlands)

    Hortensius, Johanna; van der Bijl, Jaap J.; Kleefstra, Nanne; Houweling, Sebastiaan T.; Bilo, Henk J. G.


    Purpose This study investigated the advice given by diabetes educators in Europe, and the daily practice of Dutch patients with diabetes regarding the use of the first or second drop of blood and other aspects concerning self-monitoring of blood glucose (SMBG). Method During a diabetes conference in

  20. The Biology and Clinical Utility of EBV Monitoring in Blood. (United States)

    Kanakry, Jennifer; Ambinder, Richard


    Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker.

  1. Blood pressure monitor with a position sensor for wrist placement to eliminate hydrostatic pressure effect on blood pressure measurement. (United States)

    Sato, Hironori; Koshimizu, Hiroshi; Yamashita, Shingo; Ogura, Toshihiko


    Accurate measurement of blood pressure at wrist requires the heart and wrist to be kept at the same level to avoid the effects of hydrostatic pressure. Although a blood pressure monitor with a position sensor that guides appropriate forearm angle without use of a chair and desk has already been proposed, a similar functioning device for measuring upper arm blood pressure with a chair and desk is needed. In this study, a calculation model was first used to explore design of such a system. The findings were then implemented into design of a new blood pressure monitor. Results of various methods were compared. The calculation model of the wrist level from arthrosis angles and interarticulars lengths was developed and considered using published anthropometric dimensions. It is compared with 33 volunteer persons' experimental results. The calculated difference of level was -4.1 to 7.9 (cm) with a fixed chair and desk. The experimental result was -3.0 to 5.5 (cm) at left wrist and -2.1 to 6.3(cm) at right wrist. The absolute difference level equals ±4.8 (mmHg) of blood pressure readings according to the calculated result. This meets the AAMI requirements for a blood pressure monitor. In the conclusion, the calculation model is able to effectively evaluate the difference between the heart and wrist level. Improving the method for maintaining wrist to heart level will improve wrist blood pressure measurement accuracy when also sitting in the chair at a desk. The leading angle of user's forearm using a position sensor is shown to work for this purpose.

  2. Contiuous gas monitoring at the volcano Galeras, Colombia (United States)

    Faber, E.; Morán, C.; Poggenburg, J.; Garzón, G.; Teschner, M.; Weinlich, F. H.


    (1) Federal Institute for Geosciences and Natural Resources, Hannover, Germany (, (2) Instituto de Investigación en Geocientifica, Mineroambiental y Nuclear - INGEOMINAS, San Juan de Pasto, Colombia (3) Instituto de Investigación en Geocientifica, Mineroambiental y Nuclear - INGEOMINAS, Manizales, Colombia A gas monitoring system has been installed on the volcano Galeras in Colombia as part of a multi-parameter station. Gases are extracted from the fumarolic vapour through a short pipe. After the water has been condensed the gas passes over sensors for carbon dioxide, sulphur dioxide and radon. Other parameters measured are temperature of the fumarolic vapour, fumarolic pressure, temperature of the ambient air and the ambient atmospheric pressure. The signals of the sensors are digitised in the electronics. The digital data are transmitted every 6 seconds by a telemetry system to the observatory down in the city of Pasto via a repeater station at the rim of the Galeras. The system at the volcano is powered by batteries connected to solar panels. Data are stored in the observatory, they are plotted and compared with all the other information of the multi-parameter station. Although the various compounds of the gas system are well preserved for the very aggressive environment close to the fumarole some problems still remain: Sulphur often plugs the pipe to the sensors and requires maintenance more often than desired. As the volcano is most of the time in clouds the installed solar power system (about 400 Watts maximum power) does not enable to run the system at the fumarole (consumption about 15 Watts) continuously during all nights. Despite these still existing problems some results have been obtained encouraging us to continue the operation of the system, to further develop the technical quality and to increase the number of fumaroles included into a growing monitoring network. In March 2000 seismic activity in the crater increased accompanied by a

  3. 静脉血气分析的文献研究%Literature Review of Venous Blood Gas Analysis

    Institute of Scientific and Technical Information of China (English)

    董敬军; 赵海伶; 黄穗华


    目的 探讨静脉血气分析在临床中的应用.方法 检索2000 ~2010年静脉血气分析方面的文献,统计分析符合标准的文献例数、检测指标、研究方法和结果等资料.结果 在所筛选的42篇文献中,关于危重医学、新生儿监测的最多,其他包括呼吸系统疾病、麻醉医学、心血管系统疾病、糖尿病等.常用的检测指标包括pH、PVO2、SvO2、ERO2等.结论 在对休克、脑卒中、新生儿窒息等患者进行诊治时,静脉血气监测弥补了动脉血气分析的不足,对临床治疗起到了良好的指导作用.%Objective To study the use of venous blood gas analysis in clinical practice. Methods Literatures regarding venous blood gas analysis published between 2000 and 2010 were retrieved to statistically analyze the number of eligible literatures, measures, study methods, and results. Results In 42 eligible literatures, the majority of them were from critical care and neonatal monitoring, in addition to respiratory disorders, anesthesiology, cardiovascular medicine, and diabetes mellitus. The common measures included pH, PvO2 , SvO2 , and ERO2. Conclusion In the diagnosis of shock, cerebral stroke and neonatal apnea,venous blood gas analysis is complementary to arterial blood gas analysis, useful for the direction of clinical treatment.

  4. 78 FR 11619 - Greenhouse Gas Reporting Rule: Revision to Best Available Monitoring Method Request Submission... (United States)


    ... protection, Administrative practice and procedures, Air pollution control, Greenhouse gases, Monitoring... AGENCY 40 CFR Part 98 RIN 2060-AR74 Greenhouse Gas Reporting Rule: Revision to Best Available Monitoring... category of the Greenhouse Gas Reporting Rule must submit requests for use of best available...

  5. Performance of the gas gain monitoring system of the CMS RPC muon detector

    CERN Document Server

    Benussi, L; Passamonti, L; Piccolo, D; Pierluigi, D; Raffone, G; Russo, A; Saviano, G; Ban, Y; Cai, J; Li, Q; Qian, S; Wang, D; Xu, Z; Zhang, F; Choi, Y; Kim, D; Choi, S; Hong, B; Kang, J W; Kang, M; Kwon, J H; Lee, K S; Park, S K; Pant, L; Singh, V B J; Kumar, A M R; Kumar, S; Chand, S; Singh, A; Bhandari, V K; Cimmino, A; Ocampo, A; Thyssen, F; Tytgat, M; Van Doninck, W; Ahmad, A; Muhamma, S; Shoaib, M; Hoorani, H; Awan, I; Ali, I; Ahmed, W; Asqhar, M I; Shahzad, H; Sayed, A; Ibrahim, A; Ali, S; Ali, R; Radi, A; Elkafrawi, T; Sharma, A; Colafranceschi, S; Abbrescia, M; Verwilligen, P; Meola, S; Cavallo, N; Braghieri, A; Montagna, P; Riccardi, C; Salvini, P; Vitulo, P; Dimitrov, A; Hadjiiska, R; Litov, L; Pavlov, B; Petkov, P; Aleksandrov, A; Genchev, V; Iaydjiev, P; Rodozov, M; Sultanov, G; Vutova, M; Stoykova, S; Ibarguen, H S; Pedraza Morales, M I; Bernardino, S Carpinteyro; Bagaturia, I


    The RPC muon detector of the CMS experiment at the LHC (CERN, Geneva, Switzerland) is equipped with a Gas Gain Monitoring (GGM) system. A report on the stability of the system during the 2011-2012 data taking run is given, as well as the observation of an effect which suggests a novel method for the monitoring of gas mixture composition.

  6. 78 FR 25392 - Greenhouse Gas Reporting Rule: Revision to Best Available Monitoring Method Request Submission... (United States)


    ... AGENCY 40 CFR Part 98 RIN 2060-AR74 Greenhouse Gas Reporting Rule: Revision to Best Available Monitoring... Greenhouse Gas Reporting Rule must submit requests for use of best available monitoring methods to the... INFORMATION CONTACT: Carole Cook, Climate Change Division, Office of Atmospheric Programs...

  7. On preventive blood pressure self-monitoring at home

    DEFF Research Database (Denmark)

    Verdezoto, Nervo; Gronvall, Erik


    -called Quantified Self). In this article, we explore socio-technical complexities that may occur when introducing preventive health-measurement technologies into older adults’ daily routines and everyday lives. In particular, the original study investigated blood pressure (BP) measurement in non-clinical settings...

  8. Monitoring infection: from blood culture to polymerase chain reaction (PCR). (United States)

    Book, Malte; Lehmann, Lutz Eric; Zhang, XiangHong; Stüber, Frank


    In patients with sepsis, diagnosis of blood stream infection (BSI) is a key concern to the therapist. Direct verification of pathogens in the blood stream executed by blood cultures (BC) still is regarded as the gold standard up to date. The quickest possible initiation of an appropriate antimicrobial therapy is a cornerstone of an effective therapy. Moreover, in this view BC can also serve to identify antimicrobial agents to target the pathogen. However, when employing BC the time needed until microbiological results are available ranges from 24 up to 72 h. Moreover, infections caused by multiple pathogens often remain undetected and concurrent antibiotic therapy may lower the overall sensitivity. Alternative pathogen characterization can be performed by polymerase chain reaction (PCR) based amplification methods. Results using PCR can be obtained within 6-8 h. Therefore, the time delay until an appropriate therapy can be reduced enormously. Moreover, these methods have the potential to enhance the sensitivity in the diagnosis of blood stream infections. Therefore, PCR based methods might be a valuable adjunct to present procedures of diagnosing bacteraemia.

  9. Oxygen and carbon dioxide monitoring during sleep. (United States)

    Amaddeo, Alessandro; Fauroux, Brigitte


    Monitoring of oxygen and carbon dioxide (CO2) is of crucial importance during sleep-disordered breathing in order to assess the consequences of respiratory events on gas exchange. Pulse oximetry (SpO2) is a simple and cheap method that is used routinely for the recording of oxygen levels and the diagnosis of hypoxemia. CO2 recording is necessary for the diagnosis of alveolar hypoventilation and can be performed by means of the end-tidal (PetCO2) or transcutaneous CO2 (PtcCO2). However, the monitoring of CO2 is not performed on a routine basis due to the lack of simple, cheap and reliable CO2 monitors. This short review summarizes some technical aspects of gas exchange recording during sleep in children before discussing the different definitions of alveolar hypoventilation and the importance of CO2 recording.

  10. Results of Vapor Space Monitoring of Flammable Gas Watch List Tanks

    Energy Technology Data Exchange (ETDEWEB)

    MCCAIN, D.J.


    This report documents the measurement of headspace gas concentrations and monitoring results from the Hanford tanks that have continuous flammable gas monitoring. The systems used to monitor the tanks are Standard Hydrogen Monitoring Systems. Further characterization of the tank off-gases was done with Gas Characterization systems and vapor grab samples. The background concentrations of all tanks are below the action level of 6250 ppm. Other information which can be derived from the measurements (such as generation rate, released rate, and ventilation rate) is also discussed.

  11. Extracorporeal gas exchange with the DeltaStream rotary blood pump in experimental lung injury. (United States)

    Dembinski, Rolf; Kopp, Rüdger; Henzler, Dietrich; Hochhausen, Nadine; Oslender, Nicole; Max, Martin; Rossaint, Rolf; Kuhlen, Ralf


    In most severe cases of the acute respiratory distress syndrome, veno-venous extracorporeal membrane oxygenation (ECMO) can be used to facilitate gas exchange. However, the clinical use is limited due to the size and the concomitant risk of severe adverse events of conventionally-used centrifugal blood pumps with high extracorporeal blood volumes. The DeltaStream blood pump is a small-sized rotary blood pump that may reduce extracorporeal blood volume, foreign surfaces, contact activation of the coagulation system, and blood trauma. The aim of the present study was to test the safety and efficacy of the DeltaStream pump for ECMO in animals with normal lung function and experimental acute lung injury (ALI). Therefore, veno-venous ECMO was performed for 6 hours in mechanically ventilated pigs with normal lung function (n=6) and with ALI induced by repeated lung lavage (n=6) with a blood flow of 30% of the cardiac output. Gas flow with a FiO2 of 1.0 was set to equal blood flow. With a mean activated clotting time of 121 +/- 22 s, no circulatory impairment or thrombus formation was revealed during ECMO. Furthermore, free plasma Hb did not increase. In controls, hemodynamics and gas exchange remained unchanged. In animals with ALI, hemodynamics remained stable and gas transfer across the extracorporeal oxygenators was optimal, but only in 2 animals was a marked increase in PaO2 observed. CO2 removal was efficacious in all animals. We concluded that the DeltaStream blood pump may be used for veno-venous ECMO without major blood damage or hemodynamic impairment.

  12. 40 CFR 60.107a - Monitoring of emissions and operations for fuel gas combustion devices. (United States)


    ... this section will be considered inherently low in sulfur content. (i) Pilot gas for heaters and flares... content in the fuel gas stream going to the loading rack flare). (2) The effective date of the exemption... monitoring and recording the concentration of reduced sulfur in flare gas. The owner or operator of...

  13. Influence of different storage times and temperatures on blood gas and acid-base balance in ovine venous blood

    Directory of Open Access Journals (Sweden)

    H.A. Hussein


    Full Text Available The present study was designed to investigate the effects of storage temperature and time on blood gas and acid-base balance of ovine venous blood. Ten clinically healthy sheep were used in this study. A total number of 30 blood samples, were divided into three different groups, and were stored in a refrigerator adjusted to +4 ºC (Group I, n = 10, at RT of about 22-25 ºC (Group II, n = 10 and in an incubator adjusted to 37 ºC (Group III, n = 10 for up to 48 h. Blood samples were analysed for blood gas and acid-base indices at 0, 1, 2, 3, 4, 5, 6, 12, 24 and 48 h of storage. In comparison to the baseline value (0, there were significant decreases of blood pH of samples stored at RT and in the incubator after 1 h (p<0.05, the pH value of refrigerated blood samples exhibited insignificant changes during the study (p<0.05. Mean values of pCO2 showed a significant increase in Group I and Group III after 1 h then a progressive decrease after 12 h in all Groups. Mean pO2 values were significantly higher for Group I after 2 h and for Groups II and III after 1 h (p<0.05. In general, base excess decreased significantly for all the groups during the study especially in Groups II and III. In comparison with baseline values, in all groups, bicarbonate (HCO3 increased between 1 h and 6 h (p<0.05, and later decreased at the end of the study (p<0.05. In conclusion, status of acid-base indices of the samples stored at refrigerator and RT were found within normal reference range and it may be of clinical diagnostic use for up to 6 h.

  14. Generalized model of synthesis quality monitoring system of extraction, processing and transportation of gas

    Directory of Open Access Journals (Sweden)

    Леонид Иванович Нефедов


    Full Text Available The extraction and processing and gas transportation have been analyzed in the article. Decomposition of the process of monitoring is introduced based on that; allowing the hierarchical structure of the monitoring system is request. Scientific novelty consists in the fact that developed generalized synthesis quality model monitoring system to extract, processing and gas transportation, which allows solving the problem of synthesis of a unified system and criteria positions.

  15. Transcutaneous bilirubinometry in the newborn infant: state of the art. (United States)

    Hegyi, T


    Hyperbilirubinemia in the newborn infant continues to challenge physicians. Clinical evaluation and treatment have evolved well-established principles over the past decade. This review examines neonatal bilirubin metabolism and focuses on a recently developed clinical diagnostic tool, the transcutaneous bilirubinometer. In spite of some limitations, the transcutaneous bilirubinometer can be best applied as a screening tool to identify healthy full-term infants who require serum bilirubin determination. With proper application, this device can eliminate most invasive diagnostic testing. Optimal use of the instrument requires the relationship between the serum bilirubin concentration and the transcutaneous bilirubinometer index to be determined for each device, institution, and population.

  16. Continuous blood pressure monitoring in cirrhosis. Relations to splanchnic and systemic haemodynamics

    DEFF Research Database (Denmark)

    Møller, S; Christensen, E; Henriksen, Jens Henrik Sahl


    post-sinusoidal resistance, a low plasma volume, a short central circulation time, and the presence of ascites. In contrast, a low intra-arterial blood pressure was determined by a low serum sodium, a low haemoglobin, and a high cardiac output. Diuretic treatment did not influence this model......BACKGROUND/AIMS: Low arterial blood pressure is recognised as a distinctive factor in the hyperdynamic circulation in cirrhosis. 24-hour monitoring of the blood pressure and heart rate has recently revealed a reduced circadian variation with relation to liver function. However, associations...... with cirrhosis than in matched controls (p low 24-h arterial blood pressure were a high...

  17. Noninvasive monitoring of peripheral microcirculatory hemodynamics under varying degrees of hypoxia. (United States)

    Ovadia-Blechman, Zehava; Meilin, Aviram; Rabin, Neta; Eldar, Michael; Castel, David


    The effect of hypoxia on skin blood flow was examined in anesthetized rabbits during induction of various levels of hypoxia. Peripheral perfusion and oxygenation were monitoring using a combined system (LPT) composed of a laser Doppler flowmeter (LDF), a photoplatysmograph (PPG), and a transcutaneous oxygen tension monitor (tc-PO2). Central blood parameters (PaO2, HCO3(-), SaO2, pH, and lactate) were measured concomitantly throughout the experiment. A continuous decline was found in both peripheral and central values, depending on the severity of the hypoxia. The results clearly indicate that monitoring peripheral indices with the LPT system enables monitoring changes of vital blood parameters during hypoxia. The system has clinical potential for sensitive and noninvasive monitoring of vital variables during medical procedures in clinics, as well as for homecare for patients with respiratory diseases. Minimizing the system may be useful in various conditions of exposure to low oxygen levels, such as during mountain climbing.

  18. Evaluation of transcutaneous and end-tidal carbon dioxide levels during inhalation sedation in volunteers. (United States)

    Satoh, Kenichi; Chikuda, Mami; Ohashi, Ayako; Kumagai, Miho; Kuji, Akiyoshi; Joh, Shigeharu


    Measurement of end-tidal carbon dioxide (PETCO2) is useful because of its noninvasiveness, continuity, and response time when sudden changes in ventilation occur during inhalation sedation. We compared the accuracy of PETCO2 using a nasal mask and nasal cannula with the accuracy of transcutaneous carbon dioxide (TC-CO2) and determined which method is more useful during inhalation sedation in volunteers. We used a modified nasal mask (MNM) and modified nasal cannula (MNC) for measurement of PETCO2. The capnometer measured PETCO2 in the gas expired from the nasal cavity by means of two devices. The volunteers received supplemental O2 by means of each device at a flow rate of 6 L/min. After the volunteers lay quietly for 5 min with a supply of 100 % O2, they received supplemental N2O by means of each device at concentrations of 10, 20, and 25 % for 5 min and 30 % for 25 min. The correlation coefficient was poorer in the MNM than in the MNC, and the mean difference between TC-CO2 and PETCO2 in the MNM was greater than that in the MNC. The difference between the TC-CO2 and PETCO2 ranged from 3 to 6 mmHg in the MNM and from 2 to 5 mmHg in the MNC. The difference between two variables against the TC-CO2 and the CO2 waveforms obtained by means of the two devices were within the clinically acceptable range. Our two devices can provide continuous monitoring of PETCO2 with a supply of N2O/O2 in patients undergoing inhalation sedation.

  19. Skin perfusion pressure measured by isotope washout in legs with arterial occlusive disease. Evaluation of different tracers, comparison to segmental systolic pressure, angiography and transcutaneous oxygen tension and variations during changes in systemic blood pressure

    DEFF Research Database (Denmark)

    Holstein, P; Trap-Jensen, J; Bagger, H;


    digit (strain gauge technique). The two different methods correlated statistically significant at all four levels, but the systolic blood pressures were higher than the SPP in particular in diabetic legs; (3) Angiograms in 35 legs with AOD showed that the SPP on the ankle was only consistently decreased......The skin perfusion pressure (SPP) measured as the isotope washout cessation external pressure is valuable in selection of major amputation level. Five methodological investigations important to clinical use were carried out: (1) In five normal legs and 10 legs with arterial occlusive disease (AOD......Hg (range 18-98) (P less than 0.02). The average washout constant for the three different tracers were approximately equal and correlated statistically significant with the SPP; (2) In 59 legs with AOD, segmental SPP was compared to segmental systolic blood pressures on the thigh, calf, ankle and first...

  20. Lifetime-based portable instrument for blood gas analysis (United States)

    Kieslinger, Dietmar; Trznadel, Karolina; Oechs, Karin; Draxler, Sonja; Lippitsch, Max E.


    A portable, compact device for measuring blood gases by using the fluorescence decay time as the information carrier is presented. The instrument is based on solid state technology only, thus using LEDs for excitation and a photodiode as detector. A capillary coated on its inner surface with different sensing membranes serves as a sample compartment and an optical sensor element simultaneously. Furthermore, due to inhomogeneous waveguiding in the capillary walls, only the fluorescent light is guided. Technical details of the electronic circuit, the optical design and the instrumental performance will be discussed.

  1. Improving the gas gain monitoring system in multiwire proportional chambers for MUON detector of LHCb experiment.

    CERN Document Server

    Ruvinskaia, Ekaterina


    The gas gain monitoring system in multi-wire proportional chambers for MUON detector of LHCb has been constructed and commissioned. It includes an online- monitoring, tools for analysis the archived data and an alarm system on the quality of the gas mixture. Finally, it will be implemented in the main ECS of LHCb for MUON detector and as a part of safety system of LHCb as a permanent online monitor of the quality of the gas mixture in MWPCs. The main advantage of this setup is a monitoring of Gas Gain (GG) in MWPCs with radioactive sources independently from the presence of beam at LHC. It also provides an option for prompt reaction in case of a problem with the gas.

  2. Noninvasive cerebral blood oxygenation monitoring: clinical test of multiwavelength optoacoustic system (United States)

    Petrov, Y. Y.; Prough, D. S.; Petrova, I.; Patrikeev, I. A.; Cicenaite, I.; Esenaliev, R. O.


    Continuous monitoring of cerebral blood oxygenation is critically important for treatment of patients with life-threatening conditions like severe brain injury or during cardiac surgery. We designed and built a novel multiwavelength optoacoustic system for noninvasive, continuous, and accurate monitoring of cerebral blood oxygenation. We use an Optical Parametric Oscillator as a light source. We successfully tested the system in vitro as well as in vivo in large animals (sheep) through thick tissues overlying blood vessels which drain venous blood out of the brain (e.g., superior sagittal sinus or jugular vein). Here we present the results of clinical tests of the system for continuous noninvasive cerebral blood oxygenation monitoring in the internal jugular vein of healthy volunteers. We applied our custom-built optoacoustic probe (which incorporated a wide-band acoustic transducer and an optical fiber) to the neck area overlying the internal jugular vein. We performed measurements with volunteers at 18 wavelengths in the near-infrared spectral range. Despite a thick layer of overlying connective tissue and low energy used in the experiments, we recorded signals with high signal-to-noise ratios for all volunteers. We found that the temporal (independent of signal amplitude) parameters of recorded profiles for different levels of blood oxygenation correlated well with the spectrum of effective attenuation coefficients of blood.

  3. Lamotrigine in pregnancy - therapeutic drug monitoring in maternal blood, amniotic fluid, and cord blood. (United States)

    Paulzen, Michael; Lammertz, Sarah E; Veselinovic, Tanja; Goecke, Tamme W; Hiemke, Christoph; Gründer, Gerhard


    This study is the first to measure and correlate lamotrigine concentrations in maternal blood, amniotic fluid, and umbilical cord blood and account for distribution of the drug between these three compartments. Concentrations of lamotrigine were measured in six mother-infant pairs at the time of delivery. Daily doses of lamotrigine ranged between 200 and 650 mg. Daily doses were correlated with maternal serum and umbilical cord blood concentrations, and serum levels were correlated with levels in amniotic fluid. Lamotrigine levels in serum correlated strongly with the lamotrigine levels in amniotic fluid (r=+0.986, Pamniotic fluid was in a range between 0.31 and 0.75 (mean 0.58, SD 0.17); the penetration ratio into the fetal circulation, calculated on the basis of umbilical cord blood levels, was found to be in a range between 0.48 and 1.27 (mean 0.81, SD 0.28). Lamotrigine concentrations in amniotic fluid provided evidence that maternally administered lamotrigine is accessible to the fetus in a manner not previously appreciated. Furthermore, the penetration ratio into umbilical cord blood calculated here is in line with the largest study carried out so far to explore transplacental transfer.

  4. Blood infection with Enterobacter aerogenes--an unusual cause of portal vein gas. (United States)

    Fayyaz, Afshan


    Portal vein gas was once thought of as an invariably fatal condition. Now, with the availability of better equipment and expertise, the condition is more frequently diagnosed. A case of fever with rigors is presented and on ultrasound and CT examination was found to have portal venous gas which resolved with adequate antibiotic treatment. Blood culture revealed growth of gram negative bacillus; Enterobacter aerogenes. Patient was investigated further for portal vein gas, and although no other cause for the development of portal vein gas was found, she was treated with antibiotics and showed an immediate response. The aim of this case report is to highlight the benign causes of portal vein gas as well as to discuss the causes which warrant immediate surgery. Portal vein gas may herald a more ominous condition, which if intercepted in its course may result in complete cure.

  5. Transcutaneous electrostimulation for osteoarthritis of the knee: CAT

    Directory of Open Access Journals (Sweden)

    Raúl Alberto Aguilera Eguía


    Full Text Available Purpose. The aim of this CAT (Critically Appraised Topic was to check the validity of the results and effectiveness of Transcutaneous Electrical Stimulation in subjects with knee osteoarthritis and answer the question: In subjects with osteoarthritis of the knee, does low frequency transcutaneous electrical stimulation reduce pain? Method. We conducted an analysis of the article "Transcutaneous Electrical Stimulation for osteoarthritis of the knee, Cochrane Systematic Review" of Rutjes et al (2009. We analyzed validity of results, applicability and effectiveness of this intervention in patients with knee osteoarthritis. Results. Low frequency transcutaneous electrical stimulation may reduce pain in subjects with knee osteoarthritis. SMD -0.85 (95% CI -1.36 to -0.34. Conclusion. The intervention is neither endorsed nor discouraged in knee pain reduction.

  6. Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor-alpha. (United States)

    Brock, C; Brock, B; Aziz, Q; Møller, H J; Pfeiffer Jensen, M; Drewes, A M; Farmer, A D


    The vagus nerve is a central component of cholinergic anti-inflammatory pathways. We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24 hours after t-VNS, there was an increase in cardiac vagal tone and a reduction in tumor necrosis factor-α in comparison to baseline. No change was seen in blood pressure, cardiac sympathetic index or other cytokines. These preliminary data suggest that t-VNS exerts an autonomic and a subtle antitumor necrosis factor-α effect, which warrants further evaluation in larger controlled studies.

  7. Effects of anesthesia and surgery on serial blood gas values and lactate concentrations in yellow perch (Perca flavescens), walleye pike (Sander vitreus), and koi (Cyprinus carpio). (United States)

    Hanley, Christopher S; Clyde, Victoria L; Wallace, Roberta S; Paul-Murphy, Joanne; Patterson, Tamatha A; Keuler, Nicholas S; Sladky, Kurt K


    OBJECTIVE-To evaluate serial blood gas values and lactate concentrations in 3 fish species undergoing surgery and to compare blood lactate concentrations between fish that survived and those that died during the short-term postoperative period. DESIGN-Prospective cohort study. Animals-10 yellow perch, 5 walleye pike, and 8 koi. PROCEDURES-Blood samples were collected from each fish at 3 time points: before anesthesia, during anesthesia, and immediately after surgery. Blood gas values and blood lactate concentrations were measured. Fish were monitored for 2 weeks postoperatively. RESULTS-All walleye and koi survived, but 2 perch died. Blood pH significantly decreased in perch from before to during anesthesia, but increased back to preanesthesia baseline values after surgery. Blood Pco(2) decreased significantly in perch from before anesthesia to immediately after surgery, and also from during anesthesia to immediately after surgery, whereas blood Pco(2) decreased significantly in koi from before to during anesthesia. Blood Po(2) increased significantly in both perch and koi from before to during anesthesia, and also in koi from before anesthesia to immediately after surgery. For all 3 species, blood lactate concentrations increased significantly from before anesthesia to immediately after surgery. Blood lactate concentration (mean +/- SD) immediately after surgery for the 8 surviving perch was 6.06 +/- 1.47 mmol/L, which was significantly lower than blood lactate concentrations in the 2 nonsurviving perch (10.58 and 10.72 mmol/L). CONCLUSIONS AND CLINICAL RELEVANCE-High blood lactate concentrations following surgery in fish may be predictive of a poor short-term postoperative survival rate.

  8. Correlation between arterial and venous blood gas analysis parameters in patients with acute exacerbation of chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Novović Miloš


    Full Text Available Introduction. Arterial blood gas (ABG analyses have an important role in the assessment and monitoring of the metabolic and oxygen status of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD. Arterial puncture could have a lot of adverse effects, while sampling of venous blood is simpler and is not so invasive. Objective. The aim of this study was to evaluate whether venous blood gas (VBG values of pH, partial pressure of carbon dioxide (PCO2, partial oxygen pressure (PO2, bicarbonate (HCO3, and venous and arterial blood oxygen saturation (SO2 can reliably predict ABG levels in patients with acute exacerbation of COPD. Methods. Forty-seven patients with a prior diagnosis of COPD were included in this prospective study. The patients with acute exacerbation of this disease were examined at the General Hospital EMS Department in Prijepolje. ABG samples were taken immediately after venous sampling, and both were analyzed. Results. The Pearson correlation coefficients between arterial and venous parameters were 0.828, 0.877, 0.599, 0.896 and 0.312 for pH, PCO2, PO2, HCO3 and SO2, respectively. The statistically significant correlation between arterial and venous pH, PCO2 and HCO3, values was found in patients with acute exacerbation of COPD (p<0.001. Conclusion. When we cannot provide arterial blood for analysis, venous values of the pH, Pv,CO2 and HCO3 parameters can be an alternative to their arterial equivalents in the interpretation of the metabolic status in patients with acute exacerbation of COPD, while the values of venous Pv,O2 and Sv,O2 cannot be used as predictors in the assessment of oxygen status of such patients.

  9. Importance of monitoring family members in establishing sources and pathways of lead in blood. (United States)

    Gulson, B L; Mizon, K J; Korsch, M J; Howarth, D


    High precision lead isotope measurements were undertaken to establish the sources and pathways in blood and environmental samples of five families from the Broken Hill lead mining community, New South Wales, Australia. The five families were selected from 27 families investigated to illustrate the different sources and pathways of lead into blood and the importance of monitoring the whole family. The results illustrate that although the major source of lead is from the orebody, paint and petrol can be significant contributors to both house dust and blood leads. The results also show that the sources and pathways can be from the father's occupation and hence monitoring of families is important, especially in high risk locations. In two cases, the elevated blood leads in the children did not derive from their current residence but from other residences in the community.

  10. Transcutaneous electrical nerve stimulation (TENS) in angina pectoris. (United States)

    Mannheimer, C; Carlsson, C A; Vedin, A; Wilhelmsson, C


    The aim of this study was to determine the efficacy of transcutaneous electrical nerve stimulation (TENS) in the treatment of chronic stable severe angina pectoris. In a short-term study the effect of TENS was studied in 10 male patients with angina pectoris (functional class III and IV). All patients had previously been stabilized on long-term maximal oral treatment. The effects of the treatment were measured by means of repeated bicycle ergometer tests. All patients had an increased working capacity (16-85%), decreased ST segment depression and reduced recovery time during TENS. No adverse effects were observed. A long-term study of TENS on similarly selected patients showed beneficial effects in terms of pain reduction, reduced frequency of anginal attacks, increased physical activity and increased working capacity during bicycle ergometer tests. An invasive study was carried out with respect to systemic and coronary hemodynamics and myocardial metabolism during pacing provoked myocardial ischemia in 13 patients. The results showed that TENS led to an increased tolerance to pacing, improved lactate metabolism, less pronounced ST segment depression. A drop in systolic blood pressure during TENS treatment at identical pacing rates indicated a decreased afterload. An increased coronary flow to ischemic areas in the myocardium was supported by the fact that the rate pressure product during anginal pain increased during TENS.

  11. Effects of Imidapril on Venous Blood Gas Values in Broiler Chickens Exposed to Low Ambient Temperature

    Institute of Scientific and Technical Information of China (English)

    Xueqin HAO; Meng LI; Shouyan ZHANG; Yongshu WANG; Tongwen SUN


    [Objective] This study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens.[Method] Twenty-four chickens were randomly divided into three groups (n=8),control group,low temperature group and imidapril group.Chickens in low temperature group and imidapril group were exposed to low ambient temperature (12-18 ℃) from age at 14 d to 45 d,whereas the control group was exposed to 24-30 ℃; chickens in imidapril group were gavaged with imidapril (3 mg/kg) once daily for 30 d.At age of 45 d,blood was taken from wing vein and blood gas parameters were evaluated by blood gas analyzer in Luoyang Central Hospital Affiliated to Zhengzhou University.[Result] Imidapril significantly increased hematocrit (HCT) and total hemoglobin content (THBC) and blood Na concentration in broiler chickens exposed to low ambient temperature.No significant differences were observed in pH,Pco2,Po2,K+,Ca2+,HCO3-,HCO3std,Tco2,BE and SO2c.[Conclusion] Imidapril increases hematocrit,total hemoglobin content and blood Na+concentration in chickens exposed to low ambient temperature.

  12. Electromagnetic Radiofrequency Radiation Emitted from GSM Mobile Phones Decreases the Accuracy of Home Blood Glucose Monitors. (United States)

    Mortazavi, Smj; Gholampour, M; Haghani, M; Mortazavi, G; Mortazavi, Ar


    Mobile phones are two-way radios that emit electromagnetic radiation in microwave range. As the number of mobile phone users has reached 6 billion, the bioeffects of exposure to mobile phone radiation and mobile phone electromagnetic interference with electronic equipment have received more attention, globally. As self-monitoring of blood glucose can be a beneficial part of diabetes control, home blood glucose testing kits are very popular. The main goal of this study was to investigate if radiofrequency radiation emitted from a common GSM mobile phone can alter the accuracy of home blood glucose monitors. Forty five female nondiabetic students aged 17-20 years old participated in this study. For Control-EMF group (30 students), blood glucose concentration for each individual was measured in presence and absence of radiofrequency radiation emitted by a common GSM mobile phone (HTC touch, Diamond 2) while the phone was ringing. For Control- Repeat group (15 students), two repeated measurements were performed for each participant in the absence of electromagnetic fields. The magnitude of the changes between glucose levels in two repeated measurements (|ΔC|) in Control-Repeat group was 1.07 ± 0.88 mg/dl while this magnitude for Control-EMF group was 7.53 ± 4.76 mg/dl (P < 0.001, two-tailed test). To the best of our knowledge, this is the first study to assess the electromagnetic interference in home blood glucose monitors. It can be concluded that electromagnetic interference from mobile phones has an adverse effect on the accuracy of home blood glucose monitors. We suggest that mobile phones should be used at least 50 cm away from home blood glucose monitors.

  13. Transcutaneous optical power converter for implantable devices (United States)

    Tamura, Toshiyo; Shamsuddin, A. K. M.; Kawarada, Atsushi; Togawa, Tatsuo; Oberg, P. Ake


    An optical transcutaneous power converter has been developed for the power supply of implanted devices. It consists of a light source, optical fiber system and a photo detector. The light source is either a halogen lamp or continuous high-power laser diode which illuminated skin surface. The light penetrates through the skin to the solar cells. The preliminary experiments with a slice of tissue in between the light source and the solar cells showed that the power transfer efficiency was 40% in comparison to direct illumination of the solar cells. The maximum electric power obtained with a slice of tissue simulating the skin was about 8 mW at a laser diode run at a power of 100 mW. The electric power transferred is enough to supply low power consuming CMOS circuits.

  14. The Health Behavior Schedule-II for Diabetes Predicts Self-Monitoring of Blood Glucose (United States)

    Frank, Maxwell T.; Cho, Sungkun; Heiby, Elaine M.; Lee, Chun-I; Lahtela, Adrienne L.


    The Health Behavior Schedule-II for Diabetes (HBS-IID) is a 27-item questionnaire that was evaluated as a predictor of self-monitoring of blood glucose (SMBG). The HBS-IID was completed by 96 adults with Type 2 diabetes. Recent glycosylated hemoglobin HbA1c and fasting blood glucose results were taken from participants' medical records. Only 31.3%…

  15. Fish peripheral blood mononuclear cells preparation for future monitoring applications. (United States)

    Pierrard, Marie-Aline; Roland, Kathleen; Kestemont, Patrick; Dieu, Marc; Raes, Martine; Silvestre, Frédéric


    Fish species possess many specific characteristics that support their use in ecotoxicology. Widely used in clinical research, peripheral blood mononuclear cells (PBMCs) can reasonably be exploited as relevant target cells in the assessment of environmental chemical toxicity. The current article focuses on the methods necessary to isolate, characterize, and culture fish PBMCs. These procedures were successfully applied on an endangered species, the European eel (Anguilla anguilla L.), and on an economically important and worldwide exported species, the Asian catfish (Pangasianodon hypophthalmus S.). Proteomic approaches can be useful to screen xenobiotic exposure at the protein expression level, giving the opportunity to develop early warning signals thanks to molecular signatures of toxicity. To date, a major limitation of proteomic analyses is that most protein expression profiles often reveal the same predominant and frequently differentially expressed families of proteins regardless of the experimental stressing conditions. The current study describes a methodology to get a postnuclear fraction of high quality isolated from fish PBMCs in order to perform subsequent subproteomic analyses. Applied on samples from eel, the subproteomic analysis (two-dimensional differential in-gel electrophoresis) allowed the identification by liquid chromatography-tandem mass spectrometry and searches in the full NCBInr (National Center for Biotechnology Information nonredundant) database of 66 proteins representing 36 different proteins validated through Peptide and Protein Prophet of Scaffold software.

  16. Long-term autonomous volcanic gas monitoring with Multi-GAS at Mount St. Helens, Washington, and Augustine Volcano, Alaska (United States)

    Kelly, P. J.; Ketner, D. M.; Kern, C.; Lahusen, R. G.; Lockett, C.; Parker, T.; Paskievitch, J.; Pauk, B.; Rinehart, A.; Werner, C. A.


    In recent years, the USGS Volcano Hazards Program has worked to implement continuous real-time in situ volcanic gas monitoring at volcanoes in the Cascade Range and Alaska. The main goal of this ongoing effort is to better link the compositions of volcanic gases to other real-time monitoring data, such as seismicity and deformation, in order to improve baseline monitoring and early detection of volcanic unrest. Due to the remote and difficult-to-access nature of volcanic-gas monitoring sites in the Cascades and Alaska, we developed Multi-GAS instruments that can operate unattended for long periods of time with minimal direct maintenance from field personnel. Our Multi-GAS stations measure H2O, CO2, SO2, and H2S gas concentrations, are comprised entirely of commercial off-the-shelf components, and are powered by small solar energy systems. One notable feature of our Multi-GAS stations is that they include a unique capability to perform automated CO2, SO2, and H2S sensor verifications using portable gas standards while deployed in the field, thereby allowing for rigorous tracking of sensor performances. In addition, we have developed novel onboard data-processing routines that allow diagnostic and monitoring data - including gas ratios (e.g. CO2/SO2) - to be streamed in real time to internal observatory and public web pages without user input. Here we present over one year of continuous data from a permanent Multi-GAS station installed in August 2014 in the crater of Mount St. Helens, Washington, and several months of data from a station installed near the summit of Augustine Volcano, Alaska in June 2015. Data from the Mount St. Helens Multi-GAS station has been streaming to a public USGS site since early 2015, a first for a permanent Multi-GAS site. Neither station has detected significant changes in gas concentrations or compositions since they were installed, consistent with low levels of seismicity and deformation.

  17. Photoacoustic & pulsed laser-doppler monitoring of blood concentration and perfusion in tissue


    Kolkman, Roy Gerardus Maria


    In medicine there are situations that require continuous bedside monitoring of perfusion and blood volume. Such a situation can occur when children are born prematurely. Those children have a high risk to develop a handicap, which is most likely caused by cerebral damage due to impaired brain perfusion. Monitoring cerebral perfusion can provide information for preventive treatment. In this thesis we have explored the potential of photoacoustics and laser Doppler flowmetry for measurement of c...

  18. Monitoring gas emissions can help forecast volcanic eruptions (United States)

    Kern, Christoph; Maarten de Moor,; Bo Galle,


    As magma ascends in active volcanoes, dissolved volatiles partition from melt into a gas phase, rise, and are released into the atmosphere from volcanic vents. The major components of high-temperature volcanic gas are typically water vapor, carbon dioxide, and sulfur dioxide. 

  19. Combustion/Emission Species Monitoring Ground and Flight Aeronautical Research Using a Gas Microsensor Array Project (United States)

    National Aeronautics and Space Administration — The goal of this program is to develop a miniaturized and in-situ operated gas microsensor array for the real time monitoring of chemical composition of turbine...

  20. Continuous blood pressure monitoring in cirrhosis. Relations to splanchnic and systemic haemodynamics

    DEFF Research Database (Denmark)

    Møller, Søren; Christensen, E; Henriksen, Jens Henrik


    with cirrhosis than in matched controls (p blood pressures and heart rate, pertinent variables were included in a multivariate regression model. This model revealed that independent determinants of a low 24-h arterial blood pressure were a high...... post-sinusoidal resistance, a low plasma volume, a short central circulation time, and the presence of ascites. In contrast, a low intra-arterial blood pressure was determined by a low serum sodium, a low haemoglobin, and a high cardiac output. Diuretic treatment did not influence this model......BACKGROUND/AIMS: Low arterial blood pressure is recognised as a distinctive factor in the hyperdynamic circulation in cirrhosis. 24-hour monitoring of the blood pressure and heart rate has recently revealed a reduced circadian variation with relation to liver function. However, associations...

  1. Agreement Between Doppler and Invasive Blood Pressure Monitoring in Anesthetized Dogs Weighing <5 kg. (United States)

    Kennedy, Martin J; Barletta, Michele


    The objectives of this study were to determine if Doppler (DOP) blood pressure measurements more closely estimate either invasive systolic or invasive mean arterial blood pressures (ISAP or IMAP, respectively) in small dogs under general anesthesia and to assess the ability of DOP to detect anesthesia-related hypotension in small dogs. Blood pressure measurements (n = 203) were obtained from 10 client-owned dogs. DOP, ISAP, and IMAP were recorded simultaneously, and the data were categorized into two groups: hypotensive (ISAP dogs, suggesting that DOP measures systolic arterial blood pressure in dogs dogs with hypotension, DOP met all of the performance criteria for noninvasive blood pressure monitors recommended by the American College of Veterinary Internal Medicine. DOP is an acceptably accurate and highly specific means of detecting hypotension in small dogs under general anesthesia.

  2. Improvement of a sensor unit for wrist blood pressure monitoring system (United States)

    Koo, Sangjun; Kwon, Jongwon; Park, Yongman; Ayuzenara, Odgerel; Kim, Hiesik


    A blood pressure sensor unit for ubiquitous healthcare monitoring was newly developed. The digital wrist band-type blood pressure devices for home are popular already in the market. It is useful for checking blood pressure level at home and control of hypertension. Especially, it is very essential home device to check the health condition of blood circulation disease. Nowadays many product types are available. But the measurement of blood pressure is not accurate enough compared with the mechanical type. It needs to be upgraded to assure the precise health data enough to use in the hospital. The structure, feature and output signal of capacitor type pressure sensors are analyzed. An improved design of capacitor sensor is suggested. It shows more precise health data after use on a wrist band type health unit. They can be applied for remote u-health medical service.

  3. Portable blood gas and electrolyte analyzer evaluated in a multiinstitutional study

    NARCIS (Netherlands)

    J. Lindemans (Jan); P. Hoefkens (Peter); A.L. van Kessel; M. Bonnay; W.R. Kulpmann; J.D.E. van Suijlen


    textabstractA recently introduced blood gas/electrolyte analyzer (SenDx 100((R)), renamed ABL70) intended for point-of-care, near-patient, or stat laboratory use was evaluated simultaneously in four different institutions and compared with three different laboratory ben

  4. Inert tracer gas washout from mixed venous blood: the sloping alveolar plateau

    NARCIS (Netherlands)

    Vries, W.R. de; Luijendijk, S.C.M.; Zwart, Aart


    The aim of this model study was to investigate the mechanisms underlying the sloping alveolar plateau for inert tracer gases supplied to the lung by mixed venous blood. Transpulmonary gas exchange was simulated in an asymmetric lung model for conditions at rest and in exercise. For highly soluble ga

  5. Clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring. (United States)

    Kansui, Yasuo; Matsumura, Kiyoshi; Kida, Haruko; Sakata, Satoko; Ohtsubo, Toshio; Ibaraki, Ai; Kitazono, Takanari


    Strict control of blood pressure is important to prevent cardiovascular disease, although it is sometimes difficult to decrease blood pressure to target levels. The aim of this study was to investigate the clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring. One hundred in-hospital patients, whose 24-hour average blood pressure was higher than 130/80 mmHg even after treatment with more than three antihypertensive drugs, were included in the present analysis. Circadian variation of blood pressure was evaluated by nocturnal fall in systolic blood pressure. Average blood pressures of all patients were high in both daytime and nighttime, 150.0/82.9 and 143.8/78.2 mmHg, respectively. Twenty patients had been treated with hemodialysis or peritoneal dialysis. In 63 patients out of the other 80 patients (79%), estimated glomerular filtration rate (eGFR) was also decreased (blood pressure variation only by renal dysfunction. These results show that a large number of the patients with resistant hypertension suffered from renal dysfunction, although it was difficult to explain altered circadian blood pressure variation based on renal dysfunction alone.

  6. Effects of Ambient Air Particulate Exposure on Blood-Gas Barrier Permeability and Lung Function

    DEFF Research Database (Denmark)

    Bräuner, Elvira Vaclavik; Mortensen, Jann; Møller, Peter


    Particulate air pollution is associated with increased risk of pulmonary diseases and detrimental outcomes related to the cardiovascular system, including altered vessel functions. This study's objective was too evaluate the effects of ambient particle exposure on the blood-gas permeability, lung.......5-15.8 microg/m(3) PM(10-2.5)) or filtered (91-542 particles/cm(3)) air collected above a busy street. The clearance rate of aerosolized (99m)Tc-labeled diethylenetriamine pentaacetic acid ((99m)Tc-DTPA) was measured as an index for the alveolar epithelial membrane integrity and permeability of the lung blood...... on the concentration of CC16 in plasma and urine or on the static and dynamic volumes or ventilation distribution of the lungs. The study thus demonstrates increased permeability of the alveolar blood-gas barrier following moderate exercise, whereas exposure to ambient levels of urban air particles has no detectable...

  7. Monitoring of tissue optical properties using OCT: application for blood glucose analysis (United States)

    Larin, Kirill V.; Eledrisi, Mohsen S.; Ashitkov, Taras V.; Motamedi, Massoud; Esenaliev, Rinat O.


    Noninvasive monitoring of tissue optical properties in real time could significantly improve diagnostics and management of various diseases. Recently we proposed to use high- resolution Optical Coherence Tomography (OCT) technique for measurement of tissue scattering coefficient at the depth of up to 1mm. Our pilot studies performed in vitro and in vivo demonstrated that measurement of tissue scattering with this technique can potentially be applied for noninvasive monitoring of blood glucose concentration. High resolution and coherent photon detection of the OCT technique allowed detection of glucose-induced changes in the scattering coefficient. In this paper we report results of in vivo studies performed in dog, New Zealand rabbits, and first human subjects. OCT system with the wavelength of 1300 nm was used in our experiments. OCT signal slope was measured and compared with actual blood glucose concentration. Bolus glucose injections and glucose clamping administrations were used in animal studies. OCT signals were recorded form human subjects during oral glucose tolerance test. Results obtained form both animal and human studies show good correlation between slope of the OCT signals and actual blood glucose concentration measured using standard glucometesr. Sensitivity and accuracy of blood glucose concentrations monitoring with the OCT is discussed. Obtained result suggest that OCT is a promising technique for noninvasive monitoring of tissue analytes including glucose.

  8. Self-monitoring of blood glucose in tablet-treated type 2 diabetic patients (ZODIAC)

    NARCIS (Netherlands)

    Kleefstra, Nanno; Hortensius, J.; Logtenberg, Susan; Slingerland, R. J.; Groenier, K. H.; Houweling, S. T.; Gans, R. O. B.; van Ballegooie, E; Bilo, H. J. G.


    Background: Whether self-monitoring of blood glucose (SMBG) improves glycaemic control in patients with type 2 diabetes mellitus (T2DM) not using insulin is questionable. Our aim was to investigate the effects of SMBG in patients with T2DM who were in persistent moderate glycaemic control whilst not

  9. Self-monitoring of blood glucose during pregnancy: indications and limitations

    Directory of Open Access Journals (Sweden)

    Negrato Carlos Antonio


    Full Text Available Abstract Self-monitoring of blood glucose (SMBG is an important tool to treat diabetes during pregnancy. However, proper implementation of SMBG in pregnant women requires understanding of its applications and limitations. This article reviews issues related to the implementation, efficacy, and accuracy of SMBG and discusses factors that can confound results of SMBG during pregnancy.

  10. Electronic monitoring of adherence, treatment of hypertension, and blood pressure control

    NARCIS (Netherlands)

    Onzenoort, H.A. van; Verberk, W.J.; Kroon, A.A.; Kessels, A.G.; Neef, C.; Kuy, P.H. van der; Leeuw, P.W. de


    BACKGROUND: Although it is generally acknowledged that electronic monitoring of adherence to treatment improves blood pressure (BP) control by increasing patients' awareness to their treatment, little information is available on the long-term effect of this intervention. METHODS: In this observation

  11. Noninvasive monitoring of blood glucose concentration in diabetic patients with optical coherence tomography (United States)

    Lan, Y. T.; Kuang, Y. P.; Zhou, L. P.; Wu, G. Y.; Gu, P. C.; Wei, H. J.; Chen, K.


    Optical coherence tomography (OCT) has been used to noninvasively monitor the blood glucose concentration (BGC) in healthy subjects with good accuracy and acceptable specificity. Based on this, the paper further considered the possibility of OCT in noninvasive monitoring BGC in diabetic patients. The OCT signal slope (OCTSS) changed with variation of BGC. The correlation coefficient R between BGC and OCTSS in diabetic patients was 0.91; while the correlation coefficient R in healthy volunteers was 0.78. Thus, a better linear dependence of OCTSS on BGC in diabetic patients was presented in the experiment. The results showed that the capability and accuracy of OCT in noninvasive monitoring BGC of diabetic patients, and the noninvasive monitoring BGC in diabetic patients may be better than the monitoring in the healthy subjects.

  12. Remote Blood Glucose Monitoring in mHealth Scenarios: A Review

    Directory of Open Access Journals (Sweden)

    Giordano Lanzola


    Full Text Available Glucose concentration in the blood stream is a critical vital parameter and an effective monitoring of this quantity is crucial for diabetes treatment and intensive care management. Effective bio-sensing technology and advanced signal processing are therefore of unquestioned importance for blood glucose monitoring. Nevertheless, collecting measurements only represents part of the process as another critical task involves delivering the collected measures to the treating specialists and caregivers. These include the clinical staff, the patient’s significant other, his/her family members, and many other actors helping with the patient treatment that may be located far away from him/her. In all of these cases, a remote monitoring system, in charge of delivering the relevant information to the right player, becomes an important part of the sensing architecture. In this paper, we review how the remote monitoring architectures have evolved over time, paralleling the progress in the Information and Communication Technologies, and describe our experiences with the design of telemedicine systems for blood glucose monitoring in three medical applications. The paper ends summarizing the lessons learned through the experiences of the authors and discussing the challenges arising from a large-scale integration of sensors and actuators.

  13. Ambulatory Blood Pressure Monitoring: Five Decades of More Light and Less Shadows (United States)

    Nobre, Fernando; Mion Junior, Décio


    Casual blood pressure measurements have been extensively questioned over the last five decades. A significant percentage of patients have different blood pressure readings when examined in the office or outside it. For this reason, a change in the paradigm of the best manner to assess blood pressure has been observed. The method that has been most widely used is the Ambulatory Blood Pressure Monitoring - ABPM. The method allows recording blood pressure measures in 24 hours and evaluating various parameters such as mean BP, pressure loads, areas under the curve, variations between daytime and nighttime, pulse pressure variability etc. Blood pressure measurements obtained by ABPM are better correlated, for example, with the risks of hypertension. The main indications for ABPM are: suspected white coat hypertension and masked hypertension, evaluation of the efficacy of the antihypertensive therapy in 24 hours, and evaluation of symptoms. There is increasing evidence that the use of ABPM has contributed to the assessment of blood pressure behaviors, establishment of diagnoses, prognosis and the efficacy of antihypertensive therapy. There is no doubt that the study of 24-hour blood pressure behavior and its variations by ABPM has brought more light and less darkness to the field, which justifies the title of this review. PMID:27168473

  14. Real-Time Electrical Impedimetric Monitoring of Blood Coagulation Process under Temperature and Hematocrit Variations Conducted in a Microfluidic Chip


    Lei, Kin Fong; Chen, Kuan-Hao; Tsui, Po-Hsiang; Tsang, Ngan-Ming


    Blood coagulation is an extremely complicated and dynamic physiological process. Monitoring of blood coagulation is essential to predict the risk of hemorrhage and thrombosis during cardiac surgical procedures. In this study, a high throughput microfluidic chip has been developed for the investigation of the blood coagulation process under temperature and hematocrit variations. Electrical impedance of the whole blood was continuously recorded by on-chip electrodes in contact with the blood sa...

  15. Circulating miRNA-155 is realted to blood pressure monitoring parameters

    Institute of Scientific and Technical Information of China (English)

    WU Ying; HUANG Yu-qing; HUANG Cheng; LI Jie; CAI An-ping; YU Xue-ju; ZHOU Dan


    Background Studies have shown that miRNA-155 played an important role in the process of development of hypertension.However,there is no date about miRNA-155 and blood pressure monitoring parameters.Therefore,we examined whether in hypertensive patients the expression level of plasma miRNA-155 related to 24-h ambulatory blood pressure monitoring (ABPM) parameters.Methods A cohort of adult patients scheduled to receive physical examination,office and ambulatory blood pressure monitoring.Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was used to evaluate the expression of selected miRNA-155.The miRNA-155 expression level correlation between blood pressure parameters was assessed using the Spearman correlation coefficient.Results Fifty four essential hypertension patients (25 men;mean age,53.28 ± 9.52 years) and thirty healthy volunteers (15 men;mean age,53.03 ± 5.87 years) were included.We observed higher expression level of miRNA-155 (32.31 ± 2.85 vs 27.21 ± 1.59,P < 0.001) in hypertensive patients compared to healthy control individuals.MiRNA-155 expression level showed significant positive correlation with 24 h Daytime SBP (r =0.681,P < 0.001),24 h Daytime DBP (r =0.473,P < 0.001),24 h Daytime PP (r =0.565,P < 0.001) and dipping (r =0.257,P =0.018),respectively.Conclusions Our study showed that miRNA-155 expression level was associated positively with daytime blood pressure monitoring parameters,as well as blood pressure variability,indicating a possible implication of miRNA-155 in the pathogenesis of hypertension.

  16. Changes in pulmonary blood flow do not affect gas exchange during intermittent ventilation in resting turtles

    DEFF Research Database (Denmark)

    Wang, Tobias; Hicks, James W.


    with characteristic increases in pulmonary blood flow and tachycardia. In animals with central vascular shunts, the rise in pulmonary blood flow during ventilation is associated with the development of left-to-right (L-R) cardiac shunt (pulmonary recirculation of oxygenated blood returning from the lungs......The breathing pattern of many different air-breathing vertebrates, including lungfish, anuran amphibians, turtles, crocodiles and snakes, is characterized by brief periods of lung ventilation interspersed among apnoeas of variable duration. These intermittent ventilatory cycles are associated...... experimentally. The present study measured pulmonary gas exchange in fully recovered, freely diving turtles, where changes in pulmonary blood flow were prevented by partial occlusion of the pulmonary artery. Prevention of L-R shunt during ventilation did not impair CO2 excretion and overall, oxygen uptake and CO...

  17. 21 CFR 874.3950 - Transcutaneous air conduction hearing aid system. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Transcutaneous air conduction hearing aid system... Transcutaneous air conduction hearing aid system. (a) Identification. A transcutaneous air conduction hearing aid... occluding the ear canal. The device consists of an air conduction hearing aid attached to a...

  18. Applications of ZigBee Technology in the Safety Monitoring System of Low Gas Pipeline Transportation

    Directory of Open Access Journals (Sweden)

    Wei Deyu


    Full Text Available The existing safety monitoring system of low gas pipeline transportation establishes a wired communication network monitoring system mainly on the basis of industrial bus. It has problems such as large transmission signal attenuation, complex wiring, high-labor intensity, inconvenient installation and maintenance, high maintenance cost, and so on. Featuring low cost, power-saving, reliability, stability and flexibility, the wireless sensor network established by ZigBee wireless communication technology can realize the real-time all-dimensional dynamic monitoring on parameters of low gas pipeline transportation system and overcome the shortcomings and deficiencies of wired network system.

  19. A MEMS Complete Blood Count Sensor with Vanes for Reduction in Influence of Electrolysis Gas (United States)

    Tanabe, Rikiya; Hata, Seiichi; Shimokohbe, Akira

    To develop a miniature complete blood count (CBC) analyzer for point-of-care testing (POCT), a MEMS CBC sensor based on the impedance method is discussed. A novel MEMS CBC sensor that is fabricated through a simple photolithography process using SU-8 is realized. However, the fabricated sensor exhibits a noisy output signal due to electrolysis gas. The relationship between the noise and the gas is revealed through microscopic observation and finite element method (FEM) simulation. To solve the problem of electrolysis gas, an improved MEMS CBC sensor with vanes is developed. The improved sensor is unaffected by electrolysis gas. Moreover, the signal stability of the sensor and the signals detected for latex particles are successfully evaluated.

  20. Cost estimation of hypertension management based on home blood pressure monitoring alone or combined office and ambulatory blood pressure measurements. (United States)

    Boubouchairopoulou, Nadia; Karpettas, Nikos; Athanasakis, Kostas; Kollias, Anastasios; Protogerou, Athanase D; Achimastos, Apostolos; Stergiou, George S


    This study aims at estimating the resources consumed and subsequent costs for hypertension management, using home blood pressure (BP) monitoring (HBPM) alone versus combined clinic measurements and ambulatory blood pressure monitoring (C/ABPM). One hundred sixteen untreated hypertensive subjects were randomized to use HBPM or C/ABPM for antihypertensive treatment initiation and titration. Health resources utilized within 12-months follow-up, their respective costs, and hypertension control were assessed. The total cost of the first year of hypertension management was lower in HBPM than C/ABPM arm (€1336.0 vs. €1473.5 per subject, respectively; P cost was identical in both arms. There was no difference in achieved BP control and drug expenditure (HBPM: €233.1 per subject; C/ABPM: €247.6 per subject; P = not significant), whereas the cost of BP measurements and/or visits was higher in C/ABPM arm (€393.9 vs. €516.9, per patient, respectively P cost for subsequent years (>1) was €348.9 and €440.2 per subject, respectively for HBPM and C/ABPM arm and €2731.4 versus €3234.3 per subject, respectively (P cost than C/ABPM, and the same trend is observed in 5-year projection. The results on the resources consumption can be used to make cost estimates for other health-care systems.

  1. Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Suzanne Miyamoto


    Full Text Available Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and monitoring of treatment. We report results from two separate studies using gas chromatography time-of-flight mass spectrometry (GC-TOF MS to profile metabolites in human blood samples that significantly differ from non-small cell lung cancer (NSCLC adenocarcinoma and other lung cancer cases. Metabolomic analysis of blood samples from the two studies yielded a total of 437 metabolites, of which 148 were identified as known compounds and 289 identified as unknown compounds. Differential analysis identified 15 known metabolites in one study and 18 in a second study that were statistically different (p-values <0.05. Levels of maltose, palmitic acid, glycerol, ethanolamine, glutamic acid, and lactic acid were increased in cancer samples while amino acids tryptophan, lysine and histidine decreased. Many of the metabolites were found to be significantly different in both studies, suggesting that metabolomics appears to be robust enough to find systemic changes from lung cancer, thus showing the potential of this type of analysis for lung cancer detection.

  2. Blood viscosity monitoring during cardiopulmonary bypass based on pressure-flow characteristics of a Newtonian fluid. (United States)

    Okahara, Shigeyuki; Zu Soh; Takahashi, Shinya; Sueda, Taijiro; Tsuji, Toshio


    We proposed a blood viscosity estimation method based on pressure-flow characteristics of oxygenators used during cardiopulmonary bypass (CPB) in a previous study that showed the estimated viscosity to correlate well with the measured viscosity. However, the determination of the parameters included in the method required the use of blood, thereby leading to high cost of calibration. Therefore, in this study we propose a new method to monitor blood viscosity, which approximates the pressure-flow characteristics of blood considered as a non-Newtonian fluid with characteristics of a Newtonian fluid by using the parameters derived from glycerin solution to enable ease of acquisition. Because parameters used in the estimation method are based on fluid types, bovine blood parameters were used to calculate estimated viscosity (ηe), and glycerin parameters were used to estimate deemed viscosity (ηdeem). Three samples of whole bovine blood with different hematocrit levels (21.8%, 31.0%, and 39.8%) were prepared and perfused into the oxygenator. As the temperature changed from 37 °C to 27 °C, the oxygenator mean inlet pressure and outlet pressure were recorded for flows of 2 L/min and 4 L/min, and the viscosity was estimated. The value of deemed viscosity calculated with the glycerin parameters was lower than estimated viscosity calculated with bovine blood parameters by 20-33% at 21.8% hematocrit, 12-27% at 31.0% hematocrit, and 10-15% at 39.8% hematocrit. Furthermore, deemed viscosity was lower than estimated viscosity by 10-30% at 2 L/min and 30-40% at 4 L/min. Nevertheless, estimated and deemed viscosities varied with a similar slope. Therefore, this shows that deemed viscosity achieved using glycerin parameters may be capable of successfully monitoring relative viscosity changes of blood in a perfusing oxygenator.

  3. [Influence of treatment with olmesartan on ambulatory blood pressure monitoring parameters in patients with arterial hypertension]. (United States)

    Bregvadze, T R; Tseluĭko, V I; Mishchuk, N E


    Hypertension is the most common disease of the cardiovascular system. Active treatment of hypertension with adequate control of blood pressure (BP) can prevent complications, improve life quality and increase life expectancy. One of the interesting new antihypertensive agents, from the group of angiotensin receptor blockers is olmesartan. The obvious advantages of ambulatory blood pressure monitoring to traditional one-time measurements of BP make this method perspective for quality control of anti-hypertensive therapy. The aim of this study was to evaluate the influence of treatment with olmesartan on ambulatory blood pressure monitoring parameters in patients with hypertension. 38 out-patients with hypertension at the age of 25-84 years (mean 55,3±10,6) were studied. Patients received olmesartan 20 mg daily as monotherapy (20 patients (52,6%)) or in combination with other antihypertensive agents (18 patients (47,4%)). Treatment continued for 6 months. The complex examination included: measurement of office brachial BP, electrocardiography, echocardiography and ambulatory blood pressure monitoring (ABPM). As a result of treatment, office BP and diurnal BP, according to ABPM, significantly decreased; the favorable circadian BP profile dynamics were found: significantly less frequently observed lack of reduction in BP during night (daily index - non-dipper) - 18% vs. 64% (p treatment of hypertensive patients with olmesartan provides significant decline not only in office BP, but also in diurnal BP, normalizes BP of active and passive periods, also - daily index and reduces BP variability.

  4. Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring. (United States)

    Chen, Da; Song, Shuren; Ma, Jilong; Zhang, Zhen; Wang, Peng; Liu, Weihui; Guo, Qiuquan


    Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1μl. The procoagulant activity of thromboplastin and the anticoagulant effect of heparin on the blood coagulation process were illustrated exemplarily. The measured prothrombin times showed a good linear correlation with R(2)=0.99969 and a consistency with the coefficient of variation less than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the advantages of small size, light weight, low cost, simple operation and little sample consumption, is a promising device for miniaturized, online and automated analytical system for routine diagnostics of hemostatic status and personal health monitoring.

  5. Non-constrained blood pressure monitoring using ECG and PPG for personal healthcare. (United States)

    Yoon, Youngzoon; Cho, Jung H; Yoon, Gilwon


    Blood pressure (BP) is one of the important vital signs that need to be monitored for personal healthcare. Arterial blood pressure (BP) was estimated from pulse transit time (PTT) and PPG waveform. PTT is a time interval between an R-wave of electrocardiography (ECG) and a photoplethysmography (PPG) signal. This method does not require an aircuff and only a minimal inconvenience of attaching electrodes and LED/photo detector sensors on a subject. PTT computed between the ECG R-wave and the maximum first derivative PPG was strongly correlated with systolic blood pressure (SBP) (R = -0.712) compared with other PTT values, and the diastolic time proved to be appropriate for estimation diastolic blood pressure (DBP) (R = -0.764). The percent errors of SBP using the individual regression line (4-11%) were lower than those using the regression line obtained from all five subjects (9-14%). On the other hand, the DBP estimation did not show much difference between the individual regression (4-10%) and total regression line (6-10%). Our developed device had a total size of 7 x 13.5 cm and was operated by single 3-V battery. Biosignals can be measured for 72 h continuously without external interruptions. Through a serial network communication, an external personal computer can monitor measured waveforms in real time. Our proposed method can be used for non-constrained, thus continuous BP monitoring for the purpose of personal healthcare.

  6. Gas dynamics considerations in a non-invasive profile monitor for charged particle beams

    CERN Document Server

    Tzoganis, Vasilis; Welsch, Carsten P


    A non-invasive, gas jet-based, beam profile monitor has been developed in the QUASAR Group at the Cockcroft Institute, UK. This allows on-line measurement of the 2-dimensional transverse profile of particle beams with negligible disturbance to either primary beam or accelerator vacuum. The monitor is suitable for use with beams across a wide range of energies and intensities. In this setup a nozzle-skimmer system shapes a thin supersonic gas jet into a curtain. However, the small dimensions of the gas inlet nozzle and subsequent skimmers were shown to be the cause of many operational problems. In this paper, the dynamics of gas jet formation transport and shaping is discussed before an image-processing based alignment technique is introduced. Furthermore, experimental results obtained with a 5 keV electron beam are discussed and the effects of gas stagnation pressure on the acquired beam are presented.

  7. Gas monitoring data anomaly identification based on spatio-temporal correlativity analysis

    Institute of Scientific and Technical Information of China (English)

    Shi-song ZHU; Yun-jia WANG; Lian-jiang WEI


    Based on spatio-temporal correlativity analysis method,the automatic identification techniques for data anomaly monitoring of coal mining working face gas are presented.The asynchronous correlative characteristics of gas migration in working face airflow direction are qualitatively analyzed.The calculation method of asynchronous correlation delay step and the prediction and inversion formulas of gas concentration changing with time and space after gas emission in the air return roadway are provided.By calculating one hundred and fifty groups of gas sensors data series from a coal mine which have the theoretical correlativity,the correlative coefficient values range of eight kinds of data anomaly is obtained.Then the gas monitoring data anomaly identification algorithm based on spatio-temporal correlativity analysis is accordingly presented.In order to improve the efficiency of analysis,the gas sensors code rules which can express the spatial topological relations are suggested.The experiments indicate that methods presented in this article can effectively compensate the defects of methods based on a single gas sensor monitoring data.

  8. Evaluation of artificial pancreas technology for continuous blood glucose monitoring in dogs. (United States)

    Mori, Akihiro; Lee, Peter; Yokoyama, Takeshi; Oda, Hitomi; Saeki, Kaori; Miki, Yohei; Nozawa, Satoshi; Azakami, Daigo; Momota, Yutaka; Makino, Yuki; Matsubara, Takako; Osaka, Motohisa; Ishioka, Katsumi; Arai, Toshiro; Sako, Toshinori


    Artificial pancreas technology, involving "closed-loop" controls with real-time blood glucose monitoring, has been increasing in reliability as its potential for clinical use and application grows. One such device, based on this technology, is the STG-22 (Nikkiso Co., Ltd., Tokyo, Japan) artificial pancreas apparatus. In order to assess the reliability and accuracy of the device for measuring blood glucose, it is important to compare its readings to those obtained using a 'gold standard' method, such as the hexokinase method. Therefore, in the present study, canine blood [glucose] measurements using the STG-22 were compared to those obtained using a previously established commercial reagent, Quickauto-Neo GLU-HK. Furthermore, two different sample types (whole blood versus plasma constituent) were compared to determine which sample type results in more accurate and optimal readings with the STG-22. Given that the STG-22 was not primarily designed for canine blood samples, results for canine blood samples were not accurate. Measurements performed by the STG-22 with whole blood were significantly lower than reference [glucose] counterparts. Alternatively, an opposite trend was observed with plasma measurements that were significantly higher. A conversion format using the following formula, Hexokinase [glucose] = STG-22 [glucose] × 1.407 + 1.532, was observed with canine samples in our study.

  9. Transcutaneous mechanical nerve stimulation using perineal vibration: a novel method for the treatment of female stress urinary incontinence

    DEFF Research Database (Denmark)

    Sønksen, Jens; Ohl, Dana A; Bonde, Birthe;


    We defined basic guidelines for transcutaneous mechanical nerve stimulation in modifying pelvic floor responses in women and determined the efficacy of transcutaneous mechanical nerve stimulation in treating stress urinary incontinence.......We defined basic guidelines for transcutaneous mechanical nerve stimulation in modifying pelvic floor responses in women and determined the efficacy of transcutaneous mechanical nerve stimulation in treating stress urinary incontinence....

  10. Optical coherence tomography for blood glucose monitoring in vitro through spatial and temporal approaches (United States)

    De Pretto, Lucas Ramos; Yoshimura, Tania Mateus; Ribeiro, Martha Simões; Zanardi de Freitas, Anderson


    As diabetes causes millions of deaths worldwide every year, new methods for blood glucose monitoring are in demand. Noninvasive approaches may increase patient adherence to treatment while reducing costs, and optical coherence tomography (OCT) may be a feasible alternative to current invasive diagnostics. This study presents two methods for blood sugar monitoring with OCT in vitro. The first, based on spatial statistics, exploits changes in the light total attenuation coefficient caused by different concentrations of glucose in the sample using a 930-nm commercial OCT system. The second, based on temporal analysis, calculates differences in the decorrelation time of the speckle pattern in the OCT signal due to blood viscosity variations with the addition of glucose with data acquired by a custom built Swept Source 1325-nm OCT system. Samples consisted of heparinized mouse blood, phosphate buffer saline, and glucose. Additionally, further samples were prepared by diluting mouse blood with isotonic saline solution to verify the effect of higher multiple scattering components on the ability of the methods to differentiate glucose levels. Our results suggest a direct relationship between glucose concentration and both decorrelation rate and attenuation coefficient, with our systems being able to detect changes of 65 mg/dL in glucose concentration.

  11. A signal processing application for evaluating self-monitoring blood glucose strategies in a software agent model. (United States)

    Wang, Zhanle; Paranjape, Raman


    We propose the signal processing technique of calculating a cross-correlation function and an average deviation between the continuous blood glucose and the interpolation of limited blood glucose samples to evaluate blood glucose monitoring frequency in a self-aware patient software agent model. The diabetic patient software agent model [1] is a 24-h circadian, self-aware, stochastic model of a diabetic patient's blood glucose levels in a software agent environment. The purpose of this work is to apply a signal processing technique to assist patients and physicians in understanding the extent of a patient's illness using a limited number of blood glucose samples. A second purpose of this work is to determine an appropriate blood glucose monitoring frequency in order to have a minimum number of samples taken that still provide a good understanding of the patient's blood glucose levels. For society in general, the monitoring cost of diabetes is an extremely important issue, and these costs can vary tremendously depending on monitoring approaches and monitoring frequencies. Due to the cost and discomfort associated with blood glucose monitoring, today, patients expect monitoring frequencies specific to their health profile. The proposed method quantitatively assesses various monitoring protocols (from 6 times per day to 1 time per week) in nine predefined categories of patient agents in terms of risk factors of health status and age. Simulation results show that sampling 6 times per day is excessive, and not necessary for understanding the dynamics of the continuous signal in the experiments. In addition, patient agents in certain conditions only need to sample their blood glucose 1 time per week to have a good understanding of the characteristics of their blood glucose. Finally, an evaluation scenario is developed to visualize this concept, in which appropriate monitoring frequencies are shown based on the particular conditions of patient agents. This base line can

  12. Practical Perspectives On The In-Vitro And In-Vivo Evaluation Of A Fiber Optic Blood Gas Sensor (United States)

    Hansmann, Douglas R.; Gehrich, John L.


    A new optical fluorescence-based microsensor has been developed to continuously monitor intra-arterial blood gases (pH, pCO2, p02) with a probe sufficiently small to share the lumen of a 20 gauge arterial catheter without compromising pressure fidelity or ease of blood withdrawal. The evaluation of performance has proceeded through a combination of in-vitro, animal and clinical studies. Each has had its own unique problems. This series of studies has re-emphasized the fact that acceptable clinical performance of even the best designed systems is not assured by success in in-vitro or even animal studies. In-vitro studies were conducted to quantify the precision and time response of the sensors and to obtain an assessment of performance characteristics in the in-vitro environment. System precision (1 S.D.) in tonometered bovine blood was 0.03 (pH units), 2 mm Hg (pCO2), and 4 mm Hg (p02). These results were collected over 40 points at two different temperatures (28 and 37 F). Average drift measured over a 200 hour continuous study period showed 0.005 pH units, 0.9 mm Hg pCO2, and 2.1 mm Hg p02 per 24 hour period. In-vivo animal studies (dog, pig, sheep, and rabbit) demonstrated the need for antithrombogenic materials. The probe system employs a covalently bound Heparin coating. However, maintenance of a patent IV drip line and adequate arterial flow was found to be critical. With proper attention to these factors, overall probe performance was found to be equivalent to that predicted by the in-vitro studies. Clinical trials in volunteers, and in critical care and surgical patients, have re-affirmed the need for antithrombogenic probe materials and adequate arterial blood flow. In addition, human studies revealed factors which can lead to sensor offsets, unless properly compensated by probe design. Subsequent clinical trials in volunteers and clinical subjects have verified that continuous monitoring of blood gases is feasible with accuracies approaching that of the

  13. A new online exhaust gas monitoring system in hydrochloric acid regeneration of cold rolling mills. (United States)

    Tuo, Long; Zheng, Xiang; Chen, Xiong


    Measuring the content of hydrogen chloride (HCl) in exhaust gas used to take time and energy. In this paper, we introduce a new online monitoring system which can output real-time data to the monitoring center. The system samples and cools exhaust gas, and after a series of processing, it will be analyzed by a specific instrument. The core part of this system is remote terminal unit (RTU) which is designed on Cortex-A8 embedded architecture. RTU runs a scaled-down version of Linux which is a good choice of OS for embedded applications. It controls the whole processes, does data acquisition and data analysis, and communicates with monitoring center through Ethernet. In addition, through a software developed for windows, the monitoring process can be remotely controlled. The new system is quite beneficial for steel industry to do environment monitoring.

  14. A CMOS-Based Tactile Sensor for Continuous Blood Pressure Monitoring

    CERN Document Server

    Kirstein, K -U; Salo, T; Hagleitner, C; Vancura, T; Hierlemann, A


    A monolithic integrated tactile sensor array is presented, which is used to perform non-invasive blood pressure monitoring of a patient. The advantage of this device compared to a hand cuff based approach is the capability of recording continuous blood pressure data. The capacitive, membrane-based sensor device is fabricated in an industrial CMOS-technology combined with post-CMOS micromachining. The capacitance change is detected by a S?-modulator. The modulator is operated at a sampling rate of 128kS/s and achieves a resolution of 12bit with an external decimation filter and an OSR of 128.

  15. Double Invasive Blood Pressure Monitoring for Cesarean Delivery in a Pregnant Woman With Aortic Coarctation. (United States)

    Barcellos, Bruno Mendonça; Loureiro, Fernanda Martins; Sampaio, Livia Fernandes; de Resende, Marco Antonio Cardoso


    Aortic coarctation is a discrete narrowing of the proximal thoracic aorta. It is poorly tolerated during pregnancy because of its association with hypertension, cerebrovascular accident, and aortic rupture. We report a case of severe uncorrected congenital aortic coarctation in a 31-year-old symptomatic pregnant woman at 29 weeks of gestation who underwent successful cesarean delivery with an epidural anesthetic technique. Transthoracic echocardiography showed a gradient of 75 mm Hg. To avoid undiagnosed arterial hypotension and inadequate uteroplacental flow distal to the coarctation, double (radial and femoral) invasive arterial blood pressure measurement was used to monitor both pre- and postcoarctation arterial blood pressure.

  16. Environmental Monitoring and the Gas Industry: Program Manager Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Gregory D. Gillispie


    This document has been developed for the nontechnical gas industry manager who has the responsibility for the development of waste or potentially contaminated soil and groundwater data or must make decisions based on such data for the management or remediation of these materials. It explores the pse of common analytical chemistry instrumentation and associated techniques for identification of environmentally hazardous materials. Sufficient detail is given to familiarize the nontechnical reader with the principles behind the operation of each technique. The scope and realm of the techniques and their constituent variations are portrayed through a discussion of crucial details and, where appropriate, the depiction of real-life data. It is the author's intention to provide an easily understood handbook for gas industry management. Techniques which determine the presence, composition, and quantification of gas industry wastes are discussed. Greater focus is given to traditional techniques which have been the mainstay of modem analytical benchwork. However, with the continual advancement of instrumental principles and design, several techniques have been included which are likely to receive greater attention in fiture considerations for waste-related detection. Definitions and concepts inherent to a thorough understanding of the principles common to analytical chemistry are discussed. It is also crucial that gas industry managers understand the effects of the various actions which take place before, during, and after the actual sampling step. When a series of sample collection, storage, and transport activities occur, new or inexperienced project managers may overlook or misunderstand the importance of the sequence. Each step has an impact on the final results of the measurement process; errors in judgment or decision making can be costly. Specific techniques and methodologies for the collection, storage, and transport of environmental media samples are not

  17. [Today data management in self-monitoring of blood glucose for diabetic patients]. (United States)

    Fermon, C


    Improving diabetes treatment needs intensive glucose monitoring which is restricting for patients and time-consuming for physicians. Up-to-date tools of data management were developed, following progress in computing technology and home computing. Glucometers with memory and softwares are able to improve data management of self blood glucose monitoring, personalized interactivity with physician. They are very important to develop telemedecine systems in diabetes care. These systems are designed to complement the daily care and intensive management of diabetics through telemonitoring and telecare services.

  18. An in situ method for real-time monitoring of soil gas diffusivity (United States)

    Laemmel, Thomas; Maier, Martin; Schack-Kirchner, Helmer; Lang, Friederike


    Soil aeration is an important factor for the biogeochemistry of soils. Generally, gas exchange between soil and atmosphere is assumed to be governed by molecular diffusion and by this way fluxes can be calculated using by Fick's Law. The soil gas diffusion coefficient DS represents the proportional factor between the gas flux and the gas concentration gradient in the soil and reflects the ability of the soil to "transport passively" gas through the soil. One common way to determine DS is taking core samples in the field and measuring DS in the lab. Unfortunately this method is destructive and laborious and it can only reflect a small fraction of the whole soil. As a consequence, uncertainty about the resulting effective diffusivity on the profile scale, i.e. the real aeration status remains. We developed a method to measure and monitor DS in situ. The set-up consists of a custom made gas sampling device, the continuous injection of an inert tracer gas and inverse gas transport modelling in the soil. The gas sampling device has seven sampling depths (from 0 to -43 cm of depth) and can be easily installed into vertical holes drilled by an auger, which allows for fast installation of the system. Helium (He) as inert tracer gas was injected continuously at the lower end of the device. The resulting steady state distribution of He was used to deduce the DS depth distribution of the soil. For Finite Element Modeling of the gas-sampling-device/soil system the program COMSOL was used. We tested our new method both in the lab and in a field study and compared the results with a reference lab method using soil cores. DS profiles obtained by our in-situ method were consistent with DS profiles determined based on soil core analyses. Soil gas profiles could be measured with a temporal resolution of 30 minutes. During the field study, there was an important rain event and we could monitor the decrease in soil gas diffusivity in the top soil due to water infiltration. The effect

  19. Value of arterial blood gas analysis in patients with acute dyspnea: an observational study



    Introduction The diagnostic and prognostic value of arterial blood gas analysis (ABGA) parameters in unselected patients presenting with acute dyspnea to the Emergency Department (ED) is largely unknown. Methods We performed a post-hoc analysis of two different prospective studies to investigate the diagnostic and prognostic value of ABGA parameters in patients presenting to the ED with acute dyspnea. Results We enrolled 530 patients (median age 74 years). ABGA parameters were neither useful ...

  20. Trans-Cutaneous Bilirubinometery versus Serum Bilirubin in Neonatal Jaundice. (United States)

    Mahram, Manoochehr; Oveisi, Sonia; Jaberi, Najmeh


    Hyperbilirubinemia is a common problem in neonates and causes serious complications. Thus, serial measurements of bilirubin should be done. This assessment is done through two methods of laboratory measurement in serum sample and transcutaneous bilirubinometer. This descriptive study compared transcutaneous bilirubin assessment and laboratory serum bilirubin. Bilirubin level was assessed among 256 neonates admitted to the Qods Children's Hospital in Qazvin- Iran, because of neonatal indirect jaundice, through two methods of transcutaneous bilirubinometery from two sites of forehead and sternum and laboratory measurement of bilirubin in serum. The cases were non-hemolytic icteric term neonates weighing 2500 gram or more and had not received phototherapy or other treatments. Neonates with hemolytic forms of jaundice, sepsis and suspicious to metabolic disorders were excluded. Assessments by means of KJ-8000 transcutaneous bilirubinometer from two sites of forehead and sternum and through laboratory measurement of serum bilirubin were registered and analyzed. The results of the current study showed that there was a correlation of 0.82 between serum bilirubin and transcutaneous forehead bilirubin assessment and for the used device sensitivity of 0.844; specificity of 0.842, Youden Index of 0.709 and Shortest of 0.042 for a cut-off of 12.4 in bilirubin of participants. Furthermore, Likelihood Ratio positive and negative (LR) were 5.665 and 0.164, respectively and diagnostic Odds Ratio (LR+/LR-) was 34.56. Transcutaneous bilirubinometery can be considered as a reliable tool to assess bilirubin for the screening of neonatal jaundice in term neonates.

  1. Real-Time Monitoring of Trace Gas Concentrations in Syngas

    Directory of Open Access Journals (Sweden)

    Herbig J.


    Full Text Available A Proton Transfer Reaction Mass Spectrometer (PTR-MS was used for the analysis of syngas in an industrial Fischer-Tropsch process. A PTR-MS can detect a variety of volatile organic and inorganic compounds in real-time and with high sensitivity. Together with a multiplexer, this allows for online (real-time monitoring of the trace contaminations at different stages of a Fischer-Tropsch process. Several volatile compounds, such as HCN, H2S, RSH, carbonyls, acids, alcohols and others have been measured in Syngas. This paper describes the setup to monitor syngas using PTR-MS and summarizes the result of this proof-of-principle project.

  2. Graphical arterial blood gas visualization tool supports rapid and accurate data interpretation. (United States)

    Doig, Alexa K; Albert, Robert W; Syroid, Noah D; Moon, Shaun; Agutter, Jim A


    A visualization tool that integrates numeric information from an arterial blood gas report with novel graphics was designed for the purpose of promoting rapid and accurate interpretation of acid-base data. A study compared data interpretation performance when arterial blood gas results were presented in a traditional numerical list versus the graphical visualization tool. Critical-care nurses (n = 15) and nursing students (n = 15) were significantly more accurate identifying acid-base states and assessing trends in acid-base data when using the graphical visualization tool. Critical-care nurses and nursing students using traditional numerical data had an average accuracy of 69% and 74%, respectively. Using the visualization tool, average accuracy improved to 83% for critical-care nurses and 93% for nursing students. Analysis of response times demonstrated that the visualization tool might help nurses overcome the "speed/accuracy trade-off" during high-stress situations when rapid decisions must be rendered. Perceived mental workload was significantly reduced for nursing students when they used the graphical visualization tool. In this study, the effects of implementing the graphical visualization were greater for nursing students than for critical-care nurses, which may indicate that the experienced nurses needed more training and use of the new technology prior to testing to show similar gains. Results of the objective and subjective evaluations support the integration of this graphical visualization tool into clinical environments that require accurate and timely interpretation of arterial blood gas data.

  3. Systemic and mucosal immune response induced by transcutaneous immunization using Hepatitis B surface antigen-loaded modified liposomes. (United States)

    Mishra, Dinesh; Mishra, Pradyumna Kumar; Dubey, Vaibhav; Nahar, Manoj; Dabadghao, Sunil; Jain, N K


    We have evaluated the efficiency of novel modified liposomes (ethosomes) for transcutaneous immunization (TCI) against Hepatitis B. Antigen-loaded ethosomes were prepared and characterized for shape, lamellarity, fluidity, size distribution, and entrapment efficiency. Spectral bio-imaging and flow cytometric studies showed efficient uptake of Hepatitis B surface antigen (HBsAg)-loaded ethosomes by murine dendritic cells (DCs) in vitro, reaching a peak by 180 min. Transcutaneous delivery potential of the antigen-loaded system using human cadaver skin demonstrated a much higher skin permeation of the antigen in comparison to conventional liposomes and soluble antigen preparation. Topically applied HBsAg-loaded ethosomes in experimental mice showed a robust systemic and mucosal humoral immune response compared to intramuscularly administered alum-adsorbed HBsAg suspension, topically applied plain HBsAg solution and hydroethanolic (25%) HBsAg solution. The ability of the antigen-pulsed DCs to stimulate autologous peripheral blood lymphocytes was demonstrated by BrdU assay and a predominantly TH1 type of immune response was observed by multiplex cytometric bead array analysis. HBsAg-loaded ethosomes are able to generate a protective immune response and their ability to traverse and target the immunological milieu of the skin may find a potential application in the development of a transcutaneous vaccine against Hepatitis B virus (HBV).

  4. Wearable and low-stress ambulatory blood pressure monitoring technology for hypertension diagnosis. (United States)

    Altintas, Ersin; Takoh, Kimiyasu; Ohno, Yuji; Abe, Katsumi; Akagawa, Takeshi; Ariyama, Tetsuri; Kubo, Masahiro; Tsuda, Kenichiro; Tochikubo, Osamu


    We propose a highly wearable, upper-arm type, oscillometric-based blood pressure monitoring technology with low-stress. The low-stress is realized by new developments in the hardware and software design. In the hardware design, conventional armband; cuff, is almost halved in volume thanks to a flexible plastic core and a liquid bag which enhances the fitness and pressure uniformity over the arm. Reduced air bag volume enables smaller motor pump size and battery leading to a thinner, more compact and more wearable unified device. In the software design, a new prediction algorithm enabled to apply less stress (and less pain) on arm of the patient. Proof-of-concept experiments on volunteers show a high accuracy on both technologies. This paper mainly introduces hardware developments. The system is promising for less-painful and less-stressful 24-hour blood pressure monitoring in hypertension managements and related healthcare solutions.

  5. Non-invasive blood glucose monitoring with Raman spectroscopy: prospects for device miniaturization (United States)

    Wróbel, M. S.


    The number of patients with diabetes has reached over 350 million, and still continues to increase. The need for regular blood glucose monitoring sparks the interest in the development of modern detection technologies. One of those methods, which allows for noninvasive measurements, is Raman spectroscopy. The ability of infrared light to penetrate deep into tissues allows for obtaining measurements through the skin without its perforation. This paper presents the limitations and possibilities of non-invasive blood glucose monitoring with Raman spectroscopy. Especially focusing on the possibilities for device miniaturization. Such device incorporates a Raman spectrometer, a fiber-optical probe, and a computing device (microcontroller, smartphone, etc.) which calculates the glucose concentration using specialized algorithms. Simplification of device design, as well as turbidity correction technique and a new proposed method of synchronized detection are described.

  6. Protective coating and hyperthermal atomic oxygen texturing of optical fibers used for blood glucose monitoring (United States)

    Banks, Bruce A. (Inventor)


    Disclosed is a method of producing cones and pillars on polymethylmethacralate (PMMA) optical fibers for glucose monitoring. The method, in one embodiment, consists of using electron beam evaporation to deposit a non-contiguous thin film of aluminum on the distal ends of the PMMA fibers. The partial coverage of aluminum on the fibers is randomly, but rather uniformly distributed across the end of the optical fibers. After the aluminum deposition, the ends of the fibers are then exposed to hyperthermal atomic oxygen, which oxidizes the areas that are not protected by aluminum. The resulting PMMA fibers have a greatly increased surface area and the cones or pillars are sufficiently close together that the cellular components in blood are excluded from passing into the valleys between the cones and pillars. The optical fibers are then coated with appropriated surface chemistry so that they can optically sense the glucose level in the blood sample than that with conventional glucose monitoring.

  7. Analytical methods and monitoring system for E-beam flue gas treatment process (United States)

    Licki, J.; Chmielewski, A. G.; Iller, E.; Zakrzewska-Trznadel, G.; Tokunaga, O.; Hashimoto, S.


    The results of reliable and precise measurement of gas composition in different key points of e-beam installation are necessary for its proper operation and control. Only the composition of flue gas coming into installation is adequate to composition of flue gas emitted from coal-fired boiler. At other points of e-b installation the gas composition is strongly modified by process conditions therefore specific measuring system (sampling and conditioning system and set of gas analyzers) for its determination are required. In the paper system for gas composition measurement at inlet and outlet of e-b installation are described. Process parameters are continuously monitoring by CEM system and occasionally by the grab sample system. Both system have been tested at pilot plant at EPS Kawȩczyn.

  8. Accuracy of continuous noninvasive hemoglobin monitoring for the prediction of blood transfusions in trauma patients. (United States)

    Galvagno, Samuel M; Hu, Peter; Yang, Shiming; Gao, Cheng; Hanna, David; Shackelford, Stacy; Mackenzie, Colin


    Early detection of hemorrhagic shock is required to facilitate prompt coordination of blood component therapy delivery to the bedside and to expedite performance of lifesaving interventions. Standard physical findings and vital signs are difficult to measure during the acute resuscitation stage, and these measures are often inaccurate until patients deteriorate to a state of decompensated shock. The aim of this study is to examine a severely injured trauma patient population to determine whether a noninvasive SpHb monitor can predict the need for urgent blood transfusion (universal donor or additional urgent blood transfusion) during the first 12 h of trauma patient resuscitation. We hypothesize that trends in continuous SpHb, combined with easily derived patient-specific factors, can identify the immediate need for transfusion in trauma patients. Subjects were enrolled if directly admitted to the trauma center, >17 years of age, and with a shock index (heart rate/systolic blood pressure) >0.62. Upon admission, a Masimo Radical-7 co-oximeter sensor (Masimo Corporation, Irvine, CA) was applied, providing measurement of continuous non-invasive hemoglobin (SpHb) levels. Blood was drawn and hemoglobin concentration analyzed and conventional pulse oximetry photopletysmograph signals were continuously recorded. Demographic information and both prehospital and admission vital signs were collected. The primary outcome was transfusion of at least one unit of packed red blood cells within 24 h of admission. Eight regression models (C1-C8) were evaluated for the prediction of blood use by comparing area under receiver operating curve (AUROC) at different time intervals after admission. 711 subjects had continuous vital signs waveforms available, to include heart rate (HR), SpHb and SpO2 trends. When SpHb was monitored for 15 min, SpHb did not increase AUROC for prediction of transfusion. The highest ROC was recorded for model C8 (age, sex, prehospital shock index, admission

  9. 经皮测胆红素在新生儿高胆红素血症中的应用价值%The Application Value of Transcutaneous Bilirubin in Neonatal Hyperbilirubinemia

    Institute of Scientific and Technical Information of China (English)

    周琼; 张飞忠


    Objectiv:To investigate the application value of transcutaneous bilirubin (TCB) in neonatal hyperbilirubinemia. Methods:215 cases of children with hyperbilirubinemia were dynamically tested by transcutaneous bilirubin method and blood bilirubin method at 6h, 12h, 2d, 4d, 7d and other time points respectively after the admission, and the correlation of the two sets of data was compared.Results:the values measured by transcutaneous bilirubin method and blood bilirubin method at 6h, 12h, 2d, 4d, 7d and other time points showed a linear correlation relationship (P<0.05).Conclusion:TCB has many advantages such as non-invasive, repeatable testing, easy to perform, rapid detection, dynamic monitoring of neonatal bilirubin changes, etc. it deserves clinical application.%目的::探讨经皮测胆红素(TCB)在新生儿高胆红素血症中的应用价值。方法:在入院第6h、12h、2d、4d、7d等时间点采用经皮测胆红素和经血测胆红素方法对215例高胆红素血症患儿进行动态检测,比较两组数据的相关性。结果:经皮测胆红素值和经血测胆红素值在新生儿入院第6h、12h、2d、4d、7d等时间点呈直线相关性关系(P<0.05)。结论:TCB具有无创伤性、可重复多次检测、操作简单易学、检测迅速、可动态监测新生儿胆红素变化情况等优点,值得临床推广使用。

  10. Photoacoustic a-scanning and monitoring of blood content in tissue (United States)

    Kolkman, Roy G. M.; Pilatou, Magdalena C.; Hondebrink, Erwin; de Mul, Frits F. M.


    To localize and monitor the blood content in tissue we developed a very sensitive double-ring photo-acoustical detector. PvdF has been used as piezo-electric material. In this detector also a fiber for illumination of the sample is integrated. This detector has the advantage that it is very sensitive in the forward direction. A ratio of FWHM to depth of 1:70 can be obtained with this detector.

  11. Continuous monitoring of blood pressure in children and adolescents,a review of the literature. (United States)

    Mercado, Arlene B


    Continuous or ambulatory blood pressure monitoring (CBPM or ABPM) is becoming a useful tool in the early detection of hypertension in children and adolescents. With increased obesity in pediatrics, chronic diseases such as hypertension, diabetes, dyslipidemia and metabolic syndrome which was more commonly seen in adults in the early years, can now be seen in this population. This review provides the clinical reports of the use of CBPM for diagnosis and management of hypertension in the pediatric population.

  12. Ambulatory Blood Pressure Monitoring Profile as a Useful Prognostic Tool in Patients with Primary Hypertension


    Mohamed, A. L.; Katiman, E; Hassan, J Abu


    Ambulatory blood pressure monitoring (ABPM) devices are increasingly being used in the assessment of hypertension. The purpose of the study was to investigate patient’s diurnal BP variation and to further determine the differences of BP readings between male and female patients and the effects of age in patients who attended the clinic with essential hypertension. In addition, evidence of relationship between the parameters recorded by 24-hour ABPM was also investigated. This study was conduc...

  13. A wearable diffuse reflectance sensor for continuous monitoring of cutaneous blood content

    Energy Technology Data Exchange (ETDEWEB)

    Zakharov, P; Talary, M S; Caduff, A [Solianis Monitoring AG, Leutschenbachstrasse 46, CH-8050 Zuerich (Switzerland)], E-mail:


    An optical diffuse reflectance sensor for characterization of cutaneous blood content and optimized for continuous monitoring has been developed as part of a non-invasive multisensor system for glucose monitoring. A Monte Carlo simulation of the light propagation in the multilayered skin model has been performed in order to estimate the optimal geometrical separation of the light source and detector for skin and underlying tissue. We have observed that the pathlength within the upper vascular plexus of the skin which defines the sensor sensitivity initially grows with increasing source-detector distance (SDD) before reaching a maximum at 3.5 mm and starts to decay with further increase. At the same time, for distances above 2.4 mm, the sensor becomes sensitive to muscle blood content, which decreases the specificity to skin perfusion monitoring. Thus, the SDDs in the range from 1.5 mm to 2.4 mm satisfy the requirements of sensor sensitivity and specificity. The hardware implementation of the system has been realized and tested in laboratory experiments with a venous occlusion procedure and in an outpatient clinical study in 16 patients with type 1 diabetes mellitus. For both testing procedures, the optical sensor demonstrated high sensitivity to perfusion change provoking events. The general build-up of cutaneous blood under the sensor has been observed which can be associated with pressure-induced vasodilation as a response to the sensor application.

  14. A wearable diffuse reflectance sensor for continuous monitoring of cutaneous blood content (United States)

    Zakharov, P.; Talary, M. S.; Caduff, A.


    An optical diffuse reflectance sensor for characterization of cutaneous blood content and optimized for continuous monitoring has been developed as part of a non-invasive multisensor system for glucose monitoring. A Monte Carlo simulation of the light propagation in the multilayered skin model has been performed in order to estimate the optimal geometrical separation of the light source and detector for skin and underlying tissue. We have observed that the pathlength within the upper vascular plexus of the skin which defines the sensor sensitivity initially grows with increasing source-detector distance (SDD) before reaching a maximum at 3.5 mm and starts to decay with further increase. At the same time, for distances above 2.4 mm, the sensor becomes sensitive to muscle blood content, which decreases the specificity to skin perfusion monitoring. Thus, the SDDs in the range from 1.5 mm to 2.4 mm satisfy the requirements of sensor sensitivity and specificity. The hardware implementation of the system has been realized and tested in laboratory experiments with a venous occlusion procedure and in an outpatient clinical study in 16 patients with type 1 diabetes mellitus. For both testing procedures, the optical sensor demonstrated high sensitivity to perfusion change provoking events. The general build-up of cutaneous blood under the sensor has been observed which can be associated with pressure-induced vasodilation as a response to the sensor application.

  15. Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Yonghua; Chen, Zhongping; Saxer, Christopher; Shen, Qimin; Xiang, Shaohua; Boer, Johannes F. de; Nelson, J. Stuart


    We used a novel phase-resolved optical Doppler tomographic (ODT) technique with very high flow-velocity sensitivity (10 {mu}m/s) and high spatial resolution (10 {mu}m) to image blood flow in port-wine stain (PWS) birthmarks in human skin. In addition to the regular ODT velocity and structural images, we use the variance of blood flow velocity to map the PWS vessels. Our device combines ODT and therapeutic systems such that PWS blood flow can be monitored in situ before and after laser treatment. To the authors' knowledge this is the first clinical application of ODT to provide a fast semiquantitative evaluation of the efficacy of PWS laser therapy in situ and in real time. (c) 2000 Optical Society of America.

  16. Analysis of acetylene in blood and urine using cryogenic gas chromatography-mass spectrometry. (United States)

    Kashiwagi, Masayuki; Hara, Kenji; Fujii, Hiroshi; Kageura, Mitsuyoshi; Takamoto, Mutsuo; Matsusue, Aya; Sugimura, Tomoko; Kubo, Shin-ichi


    A method for quantitative analysis of acetylene in blood and urine samples was investigated. Using cryogenic gas chromatography-mass spectrometry (GC-MS), acetylene was measured with isobutane as the internal standard in the headspace method, which revealed a linear response over the entire composite range with an excellent correlation coefficient, both in blood (R = 0.9968, range = 5.39-43.1 microg/ml) and urine (R = 0.9972, range = 2.16-10.8 microg/ml). The coefficients of variation (CV) for blood ranged from 2.62 to 11.6% for intra-day and 4.55 to 10.4% for inter-day. The CV for urine ranged from 2.38 to 3.10% for intra-day and 4.83 to 11.0% for inter-day. The recovery rate as an index of accuracy ranged from 83 to 111%. The present method showed good reliability, and is also simple and rapid. In actual samples from a charred cadaver due to acetylene explosion, the measured concentrations of acetylene by this method were 21.5 microg/ml for femoral vein blood, 17.9 microg/ml for right atrial blood, 25.5 microg/ml for left atrial blood and 7.49 microg/ml for urine. Quantification of acetylene provides important information, because the acetylene concentration is a vital reaction or sign. For example, when acetylene is filled in a closed space and then explodes, in antemortem explosion, the blood acetylene concentration of the cadaver might be significant. On the other hand, in postmortem explosion, acetylene is not detected in blood. Furthermore, when several victims are involved in one explosion, comparison of the sample concentrations can also provide useful information to establish the conditions at the accident scene; therefore, the present method is useful in forensics.

  17. New Criteria for Assessing the Accuracy of Blood Glucose Monitors meeting, October 28, 2011. (United States)

    Walsh, John; Roberts, Ruth; Vigersky, Robert A; Schwartz, Frank


    Glucose meters (GMs) are routinely used for self-monitoring of blood glucose by patients and for point-of-care glucose monitoring by health care providers in outpatient and inpatient settings. Although widely assumed to be accurate, numerous reports of inaccuracies with resulting morbidity and mortality have been noted. Insulin dosing errors based on inaccurate GMs are most critical. On October 28, 2011, the Diabetes Technology Society invited 45 diabetes technology clinicians who were attending the 2011 Diabetes Technology Meeting to participate in a closed-door meeting entitled New Criteria for Assessing the Accuracy of Blood Glucose Monitors. This report reflects the opinions of most of the attendees of that meeting. The Food and Drug Administration (FDA), the public, and several medical societies are currently in dialogue to establish a new standard for GM accuracy. This update to the FDA standard is driven by improved meter accuracy, technological advances (pumps, bolus calculators, continuous glucose monitors, and insulin pens), reports of hospital and outpatient deaths, consumer complaints about inaccuracy, and research studies showing that several approved GMs failed to meet FDA or International Organization for Standardization standards in postapproval testing. These circumstances mandate a set of new GM standards that appropriately match the GMs' analytical accuracy to the clinical accuracy required for their intended use, as well as ensuring their ongoing accuracy following approval. The attendees of the New Criteria for Assessing the Accuracy of Blood Glucose Monitors meeting proposed a graduated standard and other methods to improve GM performance, which are discussed in this meeting report.

  18. In vivo photoacoustic and photothermal cytometry for monitoring multiple blood rheology parameters. (United States)

    Galanzha, Ekaterina I; Zharov, Vladimir P


    Alterations of blood rheology (hemorheology) are important for the early diagnosis, prognosis, and prevention of many diseases, including myocardial infarction, stroke, sickle cell anemia, thromboembolism, trauma, inflammation, and malignancy. However, real-time in vivo assessment of multiple hemorheological parameters over long periods of time has not been reported. Here, we review the capabilities of label-free photoacoustic (PA) and photothermal (PT) flow cytometry for dynamic monitoring of hemorhelogical parameters in vivo which we refer to as photoacoustic and photothermal blood rheology. Using phenomenological models, we analyze correlations between both PT and PA signal characteristics in the dynamic modes and following determinants of blood rheology: red blood cell (RBC) aggregation, deformability, shape (e.g., as in sickle cells), intracellular hemoglobin distribution, individual cell velocity, hematocrit, and likely shear rate. We present ex vivo and in vivo experimental verifications involving high-speed PT imaging of RBCs, identification of sickle cells in a mouse model of human sickle cell disease and in vivo monitoring of complex hemorheological changes (e.g., RBC deformability, hematocrit and RBC aggregation). The multi-parameter platform that integrates PT, PA, and conventional optical techniques has potential for translation to clinical applications using safe, portable, laser-based medical devices for point-of-care screening of disease progression and therapy efficiency.

  19. Blood flow changes after unilateral carotid artery ligation monitored by optical coherence tomography (United States)

    Ma, Yushu; Liang, Chengbo; Suo, Yanyan; Zhao, Yuqian; Wang, Yi; Xu, Tao; Wang, Ruikang; Ma, Zhenhe


    Unilateral carotid artery ligation which could induce adaptive improvement is a classic model that has been widely used to study pathology of ischemic disease. In those studies, blood flow is an important parameter to characterize the ischemia. Optical coherence tomography (OCT) is a powerful imaging modality which can provide depth resolved images in biological tissue with high spatial and temporal resolution. SPF rats was anesthetized with isoflurane and divided into two groups. In first group, bilateral carotid artery was surgically exposed, and then left carotid artery was ligated. Blood flow changes of the contralateral carotid artery was monitored using high speed spectral domain optical coherence tomography, including the absolute flow velocity and the flow volume. In the other group, skull window was opened at the ipsilateral cerebral cortex of ligation and blood supply of small artery was measured before and after the ligation. The measured results demonstrate the blood supply compensation process after unilateral carotid artery ligation. With the superiority of high resolution, OCT is an effective technology in monitoring results of carotid artery after ligation.

  20. A compact x-ray beam intensity monitor using gas amplified sample current measurement (United States)

    Hayakawa, Shinjiro; Kobayashi, Kazuo; Gohshi, Yohichi


    Development of a compact beam intensity monitor using gas amplified sample current measurement is described. The monitor can be a powerful tool for x-ray spectroscopy and microscopy when the beam is defined by a small pinhole or slits and when the workspace around the sample is limited. The thickness of the monitor is as small as approximately 3 mm, and the dimension is 10 mm square. The photon flux is monitored by measuring x-ray excited current from an Al foil under atmospheric conditions. Emitted electrons from the Al foil can ionize surrounding air molecules, and the gas amplified current can be measured with the use of a biased grid that prevents created ion pairs from recombination.

  1. The CMS RPC gas gain monitoring system: an overview and preliminary results

    CERN Document Server

    Benussi, L; Colafranceschi, S; Colonna, D; Daniello, L; Fabbri, F L; Giardoni, M; Ortenzi, B; Paolozzi, A; Passamonti, L; Pierluigi, D; Ponzio, B; Pucci, C; Russo, A; Roselli, G; Colaleo, A; Loddo, F; Maggi, M; Ranieri, A; Abbrescia, M; Iaselli, G; Marangelli, B; Natali, S; Nuzzo, S; Pugliese, G; Romano, F; Trentadue, R; Tupputi, S; Guida, R; Polese, G; Cavallo, N; Cimmino, A; Lomidze, D; Noli, P; Paolucci, D; Piccolo, P; Sciacca, C; Baesso, P; Necchi, M; Pagano, D; Ratti, S P; Vitulo, P; Viviani, C


    The status of the CMS RPC Gas Gain Monitoring (GGM) system developed at the Frascati Laboratory of INFN (Istituto Nazionale di Fisica Nucleare) is reported on. The GGM system is a cosmic ray telescope based on small RPC detectors operated with the same gas mixture used by the CMS RPC system. The GGM gain and efficiency are continuously monitored on-line, thus providing a fast and accurate determination of any shift in working point conditions. The construction details and the first result of GGM commissioning are described.

  2. Toward Ubiquitous Blood Pressure Monitoring via Pulse Transit Time: Theory and Practice. (United States)

    Mukkamala, Ramakrishna; Hahn, Jin-Oh; Inan, Omer T; Mestha, Lalit K; Kim, Chang-Sei; Töreyin, Hakan; Kyal, Survi


    Ubiquitous blood pressure (BP) monitoring is needed to improve hypertension detection and control and is becoming feasible due to recent technological advances such as in wearable sensing. Pulse transit time (PTT) represents a well-known potential approach for ubiquitous BP monitoring. The goal of this review is to facilitate the achievement of reliable ubiquitous BP monitoring via PTT. We explain the conventional BP measurement methods and their limitations; present models to summarize the theory of the PTT-BP relationship; outline the approach while pinpointing the key challenges; overview the previous work toward putting the theory to practice; make suggestions for best practice and future research; and discuss realistic expectations for the approach.

  3. Water management in capillary gas chromatographic air monitoring systems

    Energy Technology Data Exchange (ETDEWEB)

    Tipler, A. [Perkin Elmer Corp., Norwalk, CT (United States). Fresh Aire Lab.


    Capillary gas chromatography is an excellent technique for the speciated quantitation of low-level volatile organic compounds (VOCs) in ambient air. Although GC detectors have excellent sensitivity, some sample pre-concentration will be necessary to enable detection of VOCs at sub-ppb levels. This process normally employs a cooled and/or adsorbent trap to retain the analytes from a large volume of sample air. For very volatile VOCs, a very retentive trap is used and this may also retain water present as vapor in the sample. This trapped water causes significant problems with the chromatography and detector operation and methods must be sought to remove it or eliminate its effects. This paper investigates the magnitude of the problem and examines the various alternatives for managing the trapped water. The application of some of these techniques is demonstrated in a method for the determination of volatile polar and non-polar toxic organic compounds in ambient air.

  4. Arterial blood gas analysis and electrolyte determination in neonates with asphyxia

    Institute of Scientific and Technical Information of China (English)

    Zi-Mei Sun


    Objective:To explore the value of arterial blood gas analysis and electrolyte determination in the diagnosis of neonatal asphyxia.Methods: A total of 100 neonates with asphyxia who were admitted in our department from March, 2013 to March, 2014 were included in the study and divided into the mild asphyxia group and the severe asphyxia group according to Apgar scoring. Moreover, 50 normal neonates were served as the control group and used for comparative analysis. AVL blood-gas analyzer was used to detect the levels of pH, PaO2, HCO3-, BE, PaCO2, K+, Na+, Cl-, and Ca2+.Results:The concentrations of pH, PaO2, HCO3-, and BE in the severe asphyxia group were significantly lower than those in the mild asphyxia group and the control group, while PaCO2 level was significantly higher than that in the mild asphyxia group and the control group. The comparison of the various indicators between the control group and the mild asphyxia group was not statistically significant. The comparison of serum K+, Na+,and Cl- levels among the control group, the mild asphyxia group, and the severe asphyxia group was not statistically significant. The serum Ca2+ level in the severe asphyxia group was significantly lower than that in the mild asphyxia group and the control group, while the comparison between the mild asphyxia group and the control group was also statistically significant.Conclusions:Blood gas analysis and electrolyte determination to the arterial blood in neonates can compensate for the insufficiency of Apgar scoring and provide an objective evidence for the diagnosis of neonatal asphyxia and the estimation of severity degree. Clinical combination with Apgar scoring is of great significance in enhancing the diagnosis of neonatal asphyxia and the accuracy of severity evaluation.

  5. Identification and differentiation of dragon's blood in works of art using gas chromatography/mass spectrometry. (United States)

    Baumer, Ursula; Dietemann, Patrick


    Dragon's blood is a common but non-specific name for red-coloured resins that are produced by various plants, particularly exudations from plant species belonging to the genera Dracaena and Daemonorops. Although dragon's blood is mentioned in historic sources as a colourant, it has hardly ever been identified in real artworks. This paper reports the identification and discrimination of dragon's blood produced by Dracaena cinnabari, Dracaena draco as well as Daemonorops draco and Daemonorops micracantha by means of gas chromatography/mass spectrometry (GC/MS) within the context of a routine analysis of binding media used in works of art. The detection of specific flavonoid marker compounds in both underivatised and methylated methanol extracts provided the first evidence for the use of dragon's blood from all four species in various works of art from the fifteenth to nineteenth centuries. Dragon's blood was mainly used as a red colourant in gold lacquers as well as translucent glazes and paints, e.g. in reverse-glass paintings (Hinterglasmalerei).

  6. Mechanistic studies on transcutaneous vaccine delivery : microneedles, nanoparticles and adjuvants

    NARCIS (Netherlands)

    Bal, Suzanne Marleen


    Microneedle-based transcutaneous immunisation is an appealing alternative to the classical manner of injecting vaccines by intramuscular or subcutaneous route. Importantly, as a consequence of the fact that the skin is in direct contact with the environment and should protect the body against pathog

  7. Application of Condition-Based Monitoring Techniques for Remote Monitoring of a Simulated Gas Centrifuge Enrichment Plant

    Energy Technology Data Exchange (ETDEWEB)

    Hooper, David A [ORNL; Henkel, James J [ORNL; Whitaker, Michael [ORNL


    This paper presents research into the adaptation of monitoring techniques from maintainability and reliability (M&R) engineering for remote unattended monitoring of gas centrifuge enrichment plants (GCEPs) for international safeguards. Two categories of techniques are discussed: the sequential probability ratio test (SPRT) for diagnostic monitoring, and sequential Monte Carlo (SMC or, more commonly, particle filtering ) for prognostic monitoring. Development and testing of the application of condition-based monitoring (CBM) techniques was performed on the Oak Ridge Mock Feed and Withdrawal (F&W) facility as a proof of principle. CBM techniques have been extensively developed for M&R assessment of physical processes, such as manufacturing and power plants. These techniques are normally used to locate and diagnose the effects of mechanical degradation of equipment to aid in planning of maintenance and repair cycles. In a safeguards environment, however, the goal is not to identify mechanical deterioration, but to detect and diagnose (and potentially predict) attempts to circumvent normal, declared facility operations, such as through protracted diversion of enriched material. The CBM techniques are first explained from the traditional perspective of maintenance and reliability engineering. The adaptation of CBM techniques to inspector monitoring is then discussed, focusing on the unique challenges of decision-based effects rather than equipment degradation effects. These techniques are then applied to the Oak Ridge Mock F&W facility a water-based physical simulation of a material feed and withdrawal process used at enrichment plants that is used to develop and test online monitoring techniques for fully information-driven safeguards of GCEPs. Advantages and limitations of the CBM approach to online monitoring are discussed, as well as the potential challenges of adapting CBM concepts to safeguards applications.

  8. Results of ambulatory arterial blood pressure monitoring in children with obesity

    Directory of Open Access Journals (Sweden)

    Faruk Öktem


    Full Text Available Objectives: The relationship between obesity and essential hypertension is well known. In this study, we aimed to evaluate ambulatory arterial blood pressure monitoring of obese and non-obese children who had similar demographic characteristics.Materials and methods: Seventy one children and adolescents (n=39 obesity, n=32 controls were studied. Blood pressure of the children were measured by 24 hour ambulatory blood pressure monitoring device.Results: Obese children had significantly higher mean blood pressure values (systolic 121.9±11.7 mmHg, diastolic 70.2±5.3 mmHg than control subjects (systolic 109.3±6.7 mmHg, diastolic 65.1±4.6 mmHg, p0.05. Blood pressure load was found to be increased in obese children compared to the controls (%13.6±12.9 and %2.6±3.4, respectively; p<0.05. Serum total cholesterol and LDL-cholesterol levels of obese children (181.1±33.4 and 131.1±23.1mg/dl were significantly higher than those of the controls (134.3±11.1 and 103.3±14.2 mg/dl, p<0.05.Conclusions: Obesity in children and adolescents should not be regarded as variations of normality, but as abnormality with an extremely high risk for the development of hypertension and hyperlipidemia in adulthood.

  9. Isotope Ratio Monitoring Gas Chromatography Mass Spectrometry (IRM-GCMS) (United States)

    Freeman, K. H.; Ricci, S. A.; Studley, A.; Hayes, J. M.


    On Earth, the C-13 content of organic compounds is depleted by roughly 13 to 23 permil from atmospheric carbon dioxide. This difference is largely due to isotope effects associated with the fixation of inorganic carbon by photosynthetic organisms. If life once existed on Mars, then it is reasonable to expect to observe a similar fractionation. Although the strongly oxidizing conditions on the surface of Mars make preservation of ancient organic material unlikely, carbon-isotope evidence for the existence of life on Mars may still be preserved. Carbon depleted in C-13 could be preserved either in organic compounds within buried sediments, or in carbonate minerals produced by the oxidation of organic material. A technique is introduced for rapid and precise measurement of the C-13 contents of individual organic compounds. A gas chromatograph is coupled to an isotope-ratio mass spectrometer through a combustion interface, enabling on-line isotopic analysis of isolated compounds. The isotope ratios are determined by integration of ion currents over the course of each chromatographic peak. Software incorporates automatic peak determination, corrections for background, and deconvolution of overlapped peaks. Overall performance of the instrument was evaluated by the analysis of a mixture of high purity n-alkanes of know isotopic composition. Isotopic values measured via IRM-GCMS averaged withing 0.55 permil of their conventionally measured values.

  10. 经皮穴位电刺激复合药物全麻行控制性降压对丘脑局部血流的影响%Effect of deliberated hypotension on thalamus regional blood flow during general anesthesia combined with transcutaneous electrical acupoint stimulation

    Institute of Scientific and Technical Information of China (English)

    邵晓梅; 方剑乔; 周传龙; 郭小青; 张乐乐; 金铃


    Objective To investigate the effect of deliberated hypotension on thalamus regional blood flow during general anesthesia combined with transcutaneous electrical acupoint stimulation (TEAS). Methods Fourteen beagle dogs were randomly divided into treatment group (general anesthesia. n=7) and control group (combined TEAS and general anesthesia, n = 7). TEAS(2/ l00Hz, 8-10 mA) was applied to Quchi (LI 11). Zusanli (ST 36), Hegu (LI 4), Sanyinjiao (SP 6) following isoflurane anesthesia (lvol%). Every dog received nitroprusside-induced hypotension and regional cerebral blood flow of thalamus was delected by laser Doppler at baseline(TD), the time when MAP decreased to 70%(T, ),60%(T2),50%(T3), 40%(T1),and 40%-45% maintaining for 10 min (T5), 20 min(T6), 30min(T7), 40 min(T8), 50 min(T9), 60 min(T10). Results The regional cerebral blood flow (rCBF) of treatment group (161.80±73. 65) was higher significantly than that of control group(84. 33±50.65) during the beginning of hypotension(P<0.05). The rCBF of treatment group was also higher at T5-T10 compared with To (P<0.05). The rCBF of treatment group at T1-T10 was higher than that of control group(P<0. 05). Conclusion TEAS combined with general anesthesia can benefit the brain by increasing thalamus blood flow and improving oxygen delivery during deliberated hypotension when MAP decreased to 40% of baseline for 1 hour.%目的 观察经皮穴位电刺激(TEAS)复合药物全麻行控制性降压对丘脑血流的影响.方法 成年健康雄性比格犬随机均分为单纯药物全麻行控制性降压组(对照组)和TEAS复合药物全麻行控制性降压组(观察组).对照组采用常规异氟醚吸入全麻联合硝普钠静脉泵注行控制性降压,观察组在常规全麻行控制性降压时复合TEAS,电刺激强度8~10 mA,频率2/100 Hz,取双侧“曲池”、“合谷”、“足三里”、“三阴交”穴位.两组比格犬均将MAP下降至麻醉前的40%水平,并在40%~45% MAP

  11. Validation protocol for multiple blood gas analyzers in accordance with laboratory accreditation programs

    Directory of Open Access Journals (Sweden)

    Pérsio A. R. Ebner


    Full Text Available ABSTRACTIntroduction:The results of blood gas analysis using different instrumentation can vary widely due to the methodological differences, the calibration procedures and the use of different configurations for each type of instrument.Objective:The objective of this study was to evaluate multiple analytical systems for measurement of blood gases, electrolytes and metabolites in accordance with the accreditation program (PALC of Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML.Materials and methods:20 samples were evaluated in three ABL800 Flex (Radiometer Medical ApS, Denmark blood gas analyzers, and the results were compared with those of the device in use, which was considered the reference. The analysis of variance (Anova was applied for statistical purposes, as well as the calculation of mean, standard deviation and coefficient of variation.Results:The p values obtained in the statistical analysis were: pH = 0.983, pO2 = 0.991, pCO2 = 0.353, lactate = 0.584, glucose = 0.995, ionized calcium = 0.983, sodium = 0.991, potassium = 0.926, chlorine = 0.029.Conclusion:The evaluation of multiple analytical systems is an essential procedure in the clinical laboratory for quality assurance and accuracy of the results.

  12. Large-Scale Wireless Temperature Monitoring System for Liquefied Petroleum Gas Storage Tanks

    Directory of Open Access Journals (Sweden)

    Guangwen Fan


    Full Text Available Temperature distribution is a critical indicator of the health condition for Liquefied Petroleum Gas (LPG storage tanks. In this paper, we present a large-scale wireless temperature monitoring system to evaluate the safety of LPG storage tanks. The system includes wireless sensors networks, high temperature fiber-optic sensors, and monitoring software. Finally, a case study on real-world LPG storage tanks proves the feasibility of the system. The unique features of wireless transmission, automatic data acquisition and management, local and remote access make the developed system a good alternative for temperature monitoring of LPG storage tanks in practical applications.

  13. Designing optimal greenhouse gas monitoring networks for Australia

    Directory of Open Access Journals (Sweden)

    T. Ziehn


    Full Text Available Atmospheric transport inversion is commonly used to infer greenhouse gas (GHG flux estimates from concentration measurements. The optimal location of ground based observing stations that supply these measurements can be determined by network design. Here, we use a Lagrangian particle dispersion model (LPDM in reverse mode together with a Bayesian inverse modelling framework to derive optimal GHG observing networks for Australia. This extends the network design for carbon dioxide (CO2 performed by Ziehn et al. (2014 to also minimize the uncertainty on the flux estimates for methane (CH4 and nitrous oxide (N2O, both individually and in a combined network using multiple objectives. Optimal networks are generated by adding up to 5 new stations to the base network, which is defined as two existing stations, Cape Grim and Gunn Point, in southern and northern Australia respectively. The individual networks for CO2, CH4 and N2O and the combined observing network show large similarities because the flux uncertainties for each GHG are dominated by regions of biologically productive land. There is little penalty, in terms of flux uncertainty reduction, for the combined network compared to individually designed networks. The location of the stations in the combined network is sensitive to variations in the assumed data uncertainty across locations. A simple assessment of economic costs has been included in our network design approach, considering both establishment and maintenance costs. Our results suggest that while site logistics change the optimal network, there is only a small impact on the flux uncertainty reductions achieved with increasing network size.

  14. Designing optimal greenhouse gas monitoring networks for Australia (United States)

    Ziehn, T.; Law, R. M.; Rayner, P. J.; Roff, G.


    Atmospheric transport inversion is commonly used to infer greenhouse gas (GHG) flux estimates from concentration measurements. The optimal location of ground-based observing stations that supply these measurements can be determined by network design. Here, we use a Lagrangian particle dispersion model (LPDM) in reverse mode together with a Bayesian inverse modelling framework to derive optimal GHG observing networks for Australia. This extends the network design for carbon dioxide (CO2) performed by Ziehn et al. (2014) to also minimise the uncertainty on the flux estimates for methane (CH4) and nitrous oxide (N2O), both individually and in a combined network using multiple objectives. Optimal networks are generated by adding up to five new stations to the base network, which is defined as two existing stations, Cape Grim and Gunn Point, in southern and northern Australia respectively. The individual networks for CO2, CH4 and N2O and the combined observing network show large similarities because the flux uncertainties for each GHG are dominated by regions of biologically productive land. There is little penalty, in terms of flux uncertainty reduction, for the combined network compared to individually designed networks. The location of the stations in the combined network is sensitive to variations in the assumed data uncertainty across locations. A simple assessment of economic costs has been included in our network design approach, considering both establishment and maintenance costs. Our results suggest that, while site logistics change the optimal network, there is only a small impact on the flux uncertainty reductions achieved with increasing network size.

  15. Monitoring of glucose, salt and pure water in human whole blood: An in vitro study. (United States)

    Imran, Muhammad; Ullah, Hafeez; Akhtar, Munir; Sial, Muhammad Aslam; Ahmed, Ejaz; Durr-E-Sabeeh; Ahmad, Mukhtar; Hussain, Fayyaz


    Designing and implementation of non-invasive methods for glucose monitoring in blood is main focus of biomedical scientists to provide a relief from skin puncturing of diabete patient. The objective of this research work is to investigate the shape deformations and the aggregation of red blood cells (RBCs) in the human blood after addition of three different analytes i) (0mM-400mM: Range) of glucose (C(6)H(12)O(6)), ii) (0mM-400mM: range) of pure salt (NaCl) and iii) (0mM- 350mM: range) of pure water (H(2)O). We have observed that the changes in the shape of individual cells from biconcave discs to spherical shapes and eventually the lysis of the cells at optimum concentration of glucose, salts and pure water. This demonstration also provides a base line to facilitate diabetes during partial diagnosis and monitoring of the glucose levels qualitatively both in research laboratories and clinical environment.

  16. Use of paravascular admittance waveforms to monitor relative change in arterial blood pressure (United States)

    Zielinski, Todd M.; Hettrick, Doug; Cho, Yong


    Non-invasive methods to monitor ambulatory blood pressure often have limitations that can affect measurement accuracy and patient adherence [1]. Minimally invasive measurement of a relative blood pressure surrogate with an implantable device may provide a useful chronic diagnostic and monitoring tool. We assessed a technique that uses electrocardiogram and paravascular admittance waveform morphology analysis to one, measure a time duration (vascular tone index, VTI in milliseconds) change from the electrocardiogram R-wave to admittance waveform peak and two, measure the admittance waveform minimum, maximum and magnitude as indicators of change in arterial compliance/distensibility or pulse pressure secondary to change in afterload. Methods: Five anesthetized domestic pigs (32 ± 4.2 kg) were used to study the effects of phenylephrine (1-5 ug/kg/min) on femoral artery pressure and admittance waveform morphology measured with a quadrapolar electrode array catheter placed next to the femoral artery to assess the relative change in arterial compliance due to change in peripheral vascular tone. Results: Statistical difference was observed (p blood pressure may be suitable for implantable devices to detect progression of cardiovascular disease such as hypertension.


    NARCIS (Netherlands)



    A beam profile monitor for high energy beams, which has no intercepting parts in the beam pipe, is described. It makes use of the ionization of the residual gas, which is still present in the vacuum chamber of the beam guiding system. The detection of the ionization products is performed with microc

  18. Feasibility of monitoring gas hydrate production with time-lapse VSP

    Energy Technology Data Exchange (ETDEWEB)

    Kowalsky, M.B.; Nakagawa, S.; Moridis, G.J.


    In this work we begin to examine the feasibility of using time-lapse seismic methods-specifically the vertical seismic profiling (VSP) method-for monitoring changes in hydrate accumulations that are predicted to occur during production of natural gas.

  19. Monitoring 222 Rn in soil gas of Garfagnana (Tuscany aimed at earthquake prediction

    Directory of Open Access Journals (Sweden)

    A. Pescia


    Full Text Available 222 Rn concentration in soil gas from nineteen stations of Garfagnana valley (Central ltaly was continuously monitored from December 1990 to May 1993. 222 Rn activity was measured by solid state nuclear track detector (SSNTD. Tracks detected by spark-counter and by optical microscope were proportionally constant for track densities lower than 2500 tracks/cm2. Since time variations in track density both for the same monitoring station and for different stations are significanfly higher than fluctuations in the experimental conditions, the validity of spark-counter for radon activity measurements is confirmed. Data collected in the period of monitoring indicate significant seasonal variations in radon concentration for every monitoring station. Moreover, the soil characteristics play an important role in determining the observed patterns. No significant correlation could be found between radon emission and seismicity. However, it should be noted that no earthquake with a magnitude higher than 3.5 occurred in Garfagnana during the monitoring period.

  20. Acceptance and side effects of ambulatory blood pressure monitoring: evaluation of a new technology. (United States)

    Beltman, F W; Heesen, W F; Smit, A J; May, J F; Lie, K I; Meyboom-de Jong, B


    Ambulatory blood pressure (BP) monitoring is probably becoming a clinically useful procedure for the evaluation of hypertensive patients. Previous reports have shown that the devices are safe and serious side effects are rare. Discomfort and inconveniences associated with its use are more frequent. In this study, patient acceptance of ambulatory blood pressure monitoring (ABPM) was compared with acceptance of other diagnostic procedures and their side effects were assessed. Patients were asked to fill in a form and 129 of 166 patients responded. The acceptance was measured with a visual analogue scale which ranged from 'very annoying' on the left to 'not annoying at all' on the right. All forms were collected anonymously. Mean distance (cm) of the visual likert scale was 8.6 to 9.4 for the diagnostic procedures frequently used in routine patient care. Ambulatory BP measurement (ABPM) scored 6.1 cm. Reported side effects (in 27% of patients) were: plan (9%), skin irritation (8%), noisy device (8%), inconvenience with work (3%), haematoma (2%) and other (4%). Reports from the patients on sleep quality were: 23% normal, 61% minor disturbance, 14% had sleep, and 2% did not sleep at all. It can be concluded that ambulatory BP monitoring was the diagnostic procedure with the lowest patient acceptance. Side effects of this new technology were reported by 27% of patients. However, risks are relatively minor. Sleep disturbances were very frequent and was a serious problem for 16% of patients.

  1. New Hadron Monitor By Using A Gas-Filled RF Resonator

    Energy Technology Data Exchange (ETDEWEB)

    Yonehara, Katsuya [Fermilab; Fasce, Giorgio [ECONA, Rome; Flanagan, Gene [MUONS Inc., Batavia; Johnson, Rolland [MUONS Inc., Batavia; Tollestrup, Alvin [Fermilab; Zwaska, Robert [Fermilab


    It is trend to build an intense neutrino beam facility for the fundamental physics research, e.g. LBNF at Fermilab, T2K at KEK, and CNGS at CERN. They have investigated a hadron monitor to diagnose the primary/secondary beam quality. The existing hadron monitor based on an ionization chamber is not robust in the high-radiation environment vicinity of MW-class secondary particle production targets. We propose a gas-filled RF resonator to use as the hadron monitor since it is simple and hence radiation robust in this environment. When charged particles pass through the resonator they produce ionized plasma via the Coulomb interaction with the inert gas. The beam-induced plasma changes the permittivity of inert gas. As a result, a resonant frequency in the resonator shifts with the amount of ionized electrons. The radiation sensitivity is adjustable by the inert gas pressure and the RF amplitude. The hadron profile will be reconstructed with a tomography technique in the hodoscope which consists of X, Y, and theta layers by using a strip-shaped gas resonator. The sensitivity and possible system design will be shown in this presentation.

  2. Real-time electrical impedimetric monitoring of blood coagulation process under temperature and hematocrit variations conducted in a microfluidic chip.

    Directory of Open Access Journals (Sweden)

    Kin Fong Lei

    Full Text Available Blood coagulation is an extremely complicated and dynamic physiological process. Monitoring of blood coagulation is essential to predict the risk of hemorrhage and thrombosis during cardiac surgical procedures. In this study, a high throughput microfluidic chip has been developed for the investigation of the blood coagulation process under temperature and hematocrit variations. Electrical impedance of the whole blood was continuously recorded by on-chip electrodes in contact with the blood sample during coagulation. Analysis of the impedance change of the blood was conducted to investigate the characteristics of blood coagulation process and the starting time of blood coagulation was defined. The study of blood coagulation time under temperature and hematocrit variations was shown a good agreement with results in the previous clinical reports. The electrical impedance measurement for the definition of blood coagulation process provides a fast and easy measurement technique. The microfluidic chip was shown to be a sensitive and promising device for monitoring blood coagulation process even in a variety of conditions. It is found valuable for the development of point-of-care coagulation testing devices that utilizes whole blood sample in microliter quantity.

  3. Sensitive determination of xylenes in whole blood by capillary gas chromatography with cryogenic trapping. (United States)

    Hattori, H; Iwai, M; Kurono, S; Yamada, T; Watanabe-Suzuki, K; Ishii, A; Seno, H; Suzuki, O


    A new and sensitive method for measurement of o-, m- and p-xylenes in human whole blood by capillary gas chromatography (GC) with cryogenic trapping is presented. After heating 0.5 ml of whole blood and 0.5 ml of distilled water containing the xylenes and aniline (internal standard, I.S.) in a 4.0-ml vial at 100 degrees C for 30 min, 2 ml of the headspace vapor was drawn into a glass syringe. All vapor was introduced through the GC port into an AT-Wax middle-bore capillary column in the splitless mode at an oven temperature of 5 degrees C to trap the entire analytes, and the oven temperature was then programmed up to 180 degrees C. The present conditions gave sharp peaks for xylenes and aniline (I.S.), and low background noises for whole blood samples; the peaks of p- and m-xylenes showed about 90% separation with the AT-Wax column. As much as 41.0-46.3% of xylenes, which had been spiked to whole blood could be recovered. The calibration curves showed linearity in the range of 0.1-0.5 microg/0.5 ml of whole blood. The detection limit was estimated to be about 10 ng/0.5 ml. The coefficients of intra-day and inter-day variations for xylenes were not greater than 9.38%. The data for actual detection of xylenes in post-mortem blood of self-ignition suicide cases by the present method were also presented.

  4. Is liquid heparin comparable to dry balanced heparin for blood gas sampling in intensive care unit?

    Directory of Open Access Journals (Sweden)

    Viswas Chhapola


    Full Text Available Introduction: Blood gas (BG analysis is required for management of critically ill patients in emergency and intensive care units. BG parameters can be affected by the type of heparin formulations used-liquid heparin (LH or dry balanced heparin (DBH. This study was conducted to determine whether blood gas, electrolyte, and metabolite estimations performed by using DBH and LH are comparable. Materials and Methods: A prospective study was conducted at pediatric intensive care unit (PICU of a tertiary care hospital. Paired venous samples were collected from 35 consecutive children in commercially prepared DBH syringes and custom-prepared LH syringes. Samples were immediately analyzed by blood gas analyzer and compared for pH, pCO 2 , pO 2 , HCO 3 - , Na + , K + , Cl - , and lactate. Paired comparisons were done and agreement was assessed by Bland-Altman difference plots. The 95% limits of absolute agreement (LOA were compared with the specifications for total allowable error (TEa. Results: The P values were significant for all measured parameters, with the exception of pCO 2 and K +. Bland-Altman difference plots showed wide LOA for pCO 2 , pO 2 , HCO3 - , Na + , K + , and Cl - when compared against TEa. For pCO 2 , HCO3 - , Na + , K + , and Cl - , 40%, 23%, 77%, 34%, and 54% of samples were outside the TEa limits, respectively, with LH. Conclusion: Our study showed that there is poor agreement between LH and DBH for the BG parameters pCO2, pO2, HCO3 - , K + , Na + , and Cl - and, thus, are not comparable. But for pH and lactate, LH and DBH can be used interchangeably.

  5. Satellite Monitoring Systems for Shipping and Offshore Oil and Gas Industry in the Baltic Sea

    Directory of Open Access Journals (Sweden)

    Kostianoy A.G.


    Full Text Available Shipping activities, oil production and transport in the sea, oil handled in harbors, construction and exploitation of offshore oil and gas pipelines have a number of negative impacts on the marine environment and coastal zone of the seas. In 2004-2014 we elaborated several operational satellite monitoring systems for oil and gas companies in Russia and performed integrated satellite monitoring of the ecological state of coastal waters in the Baltic, Black, Caspian, and Kara seas, which included observation of oil pollution, suspended matter, and algae bloom at a fully operational mode. These monitoring systems differ from the existing ones by the analysis of a wide spectrum of satellite, meteorological and oceanographic data, as well as by a numerical modeling of oil spill transformation and transport in real weather conditions. Our experience in the Baltic Sea includes: (1 integrated satellite monitoring of oil production at the LUKOIL-KMN Ltd. D-6 oil rig in the Southeastern Baltic Sea (Kravtsovskoe oil field in 2004-2014; (2 integrated satellite monitoring of the “Nord Stream” underwater gas pipeline construction and exploitation in the Gulf of Finland (2010-2013; (3 numerical modeling of risks of oil pollution caused by shipping along the main maritime shipping routes in the Gulf of Finland, the Baltic Proper, and in the Southeastern Baltic Sea; (4 numerical modeling of risks of oil pollution caused by oil production at D-6 oil rig and oil transportation on shore via the connecting underwater oil pipeline.

  6. Neonatal apgar scores and umbilical blood gas changes in vaginal delivery and cesarean: a comparative study

    Directory of Open Access Journals (Sweden)

    SH. Raafati


    Full Text Available Background: Umbilical cord blood gas analysis is a useful method for assessment of oxygenation and acid-base status in neonates. Severe fetal acidemia is associated with increased perinatal mortality and increased risk of subsequent impaired neurological development. Due to high percentage of C/S in our country and the effect of anesthetic medications on umbilical blood gases which can cause neonatal acidosis and hypoxemia, the study of umbilical cord blood gas in vaginal delivery versus cesarean section is mandatory. Methods: In this cross-sectional study one hundred samples were taken from Mostafa Khomeini hospital in summer 2004. The samples were taken immediately of umbilical vein after clamping the umbilical cord and analyzed after 10 minutes. Cases were classified in to 3 groups: vaginal delivery (n=40, elective C/S under general anesthesia (n=35 and C/S under spinal anesthesia (n=25. Duration of anesthesia and its effect on blood gas and infants apgar were assessed. Results: In the first group (vaginal delivery mean blood gase parameters were; pH=7.3064.73, pO2=25.246.87, HCO3=20.562.03, Apgar=8.820.38 and pCO2=41.826.57. In the second group (general anesthesia mean blood gaze parameters were: pH=7.3044.73, pO2=38.7014.02, pCO2=43.265.87, HCO3=21.1113 and apgar score=8.170.7. In the third group (spinal anesthesia mean blood gaze parameters were: pH=7.3014.50, pCO2=44.14.99, HCO3=21.382.15, pO2=26.625.5 and apgar=8.600.62. The apgar scores and pO2 demonstrated significant relationship with type of anesthesia. The apgar score was lower and pO2 was higher in C/S under general anesthesia compared with the other two groups. There was significant relationship between duration of anesthesia and umbilical pO With increasing duration of anesthesia, pO2 was reduced. Between the type of delivery and anesthesia duration with PH, pO2, pCO2 and HCO3 were not meaningful relationship (P<0.05. Conclusion: There

  7. Determination of ketone bodies in blood by headspace gas chromatography-mass spectrometry

    DEFF Research Database (Denmark)

    Holm, Karen Marie Dollerup; Linnet, Kristian; Rasmussen, Brian Schou


    A gas chromatography-mass spectrometry (GC-MS) method for determination of ketone bodies (ß-hydroxybutyrate, acetone, and acetoacetate) in blood is presented. The method is based on enzymatic oxidation of D-ß-hydroxybutyrate to acetoacetate, followed by decarboxylation to acetone, which...... was quantified by the use of headspace GC-MS using acetone-(13)C(3) as an internal standard. The developed method was found to have intra- and total interday relative standard deviations acetone+acetoacetate levels (~25 to 8300 µM) and D-ß-hydroxybutyrate levels (~30 to 16500 µM). Recovery values varied...

  8. Gas Filled RF Resonator Hadron Beam Monitor for Intense Neutrino Beam Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Yonehara, Katsuya [Fermilab; Abrams, Robert [MUONS Inc., Batavia; Dinkel, Holly [U. Missouri, Columbia; Freemire, Ben [IIT, Chicago; Johnson, Rolland [MUONS Inc., Batavia; Kazakevich, Grigory [MUONS Inc., Batavia; Tollestrup, Alvin [Fermilab; Zwaska, Robert [Fermilab


    MW-class beam facilities are being considered all over the world to produce an intense neutrino beam for fundamental particle physics experiments. A radiation-robust beam monitor system is required to diagnose the primary and secondary beam qualities in high-radiation environments. We have proposed a novel gas-filled RF-resonator hadron beam monitor in which charged particles passing through the resonator produce ionized plasma that changes the permittivity of the gas. The sensitivity of the monitor has been evaluated in numerical simulation. A signal manipulation algorithm has been designed. A prototype system will be constructed and tested by using a proton beam at the MuCool Test Area at Fermilab.

  9. Artificial neural networks for monitoring the gas turbine; Artificiella neuronnaet foer gasturbinoevervakning

    Energy Technology Data Exchange (ETDEWEB)

    Fast, Magnus; Thern, Marcus [Inst. foer Energivetenskaper, Lunds Univ. (Sweden)


    Through available historical operational data from gas turbines, fast, accurate, easy to use and reliable models can be developed. These models can be used for monitoring of gas turbines and assist in the transition from today's time-based maintenance to condition based maintenance. For the end user this means that, because only operational data is needed, they can easily develop their own tools independent of the manufacturer. Traditionally these types of models are constructed with physical relations for e.g., mass, energy and momentum. To develop a model with physical relations is often laborious and requires classified information which the end user does not have access to. Research has shown that by producing models using operational data a very high model precision can be achieved. When implementing these models in a power plant computer system the gas turbine's performance can be monitored in real time. This can facilitate fault detection at an early stage, and if necessary, stop the gas turbine before major damage occurs. For the power plant owner, this means that the gas turbine reliability is increased since the need for maintenance is minimized and the downtime is reduced. It also means that a measure of the gas turbine's overall status is continuously available, with respect to e.g. degradation, which helps in the planning of service intervals. The tool used is called artificial neural networks (ANN), a collective name for a number of algorithms for information processing that attempts to mimic the nerve cell function. Just like real networks of neurons in a brain, these artificial neural networks have the ability to learn. In this case, neural networks are trained to mimic the behavior of gas turbines by introducing them to data from real gas turbines. After a neural network is trained it represents a very accurate model of the gas turbine that it is trained to emulate.

  10. The determination of phenazone in blood plasma for obtained sistem suitable test of monitoring drug level

    Directory of Open Access Journals (Sweden)

    Mochamad Lazuardi


    Full Text Available The determining of Phenazone to human blood plasma from healthy man after separated by solid phase extraction (SPE and spectroscopic measurements has been investigated. The objective of that research was to obtain system suitable test for determine the Phenazone level in biological fluids (human blood plasma, for new performed dosage regimented in clinical dentistry. The method can be divided into the following four steps. 1. Centrifugation the blood sample, 2. Extraction from blood plasma and, 3. Separation by SPE with manual pressured, 4. Elution to SPE followed by the measurement on a spectrophotometer in the ultra violet region. The critical value of  │t │at the 5% confidence level indicates that there is no systematic error in the linearity proposed method. Recoveries for this research were obtained at ranging 93.460 to 95.598%. The coefficient variation precision of this procedure was clearly good at smallest than 2%. The analytical procedure can be carried out in one working operation as a monitored therapeutic activity.

  11. 糖尿病血糖精准监测%Accurate monitoring of blood glucose in diabetic patients

    Institute of Scientific and Technical Information of China (English)



    ABSTRACT:Precision medicine is the medical model proposed in the era of big data,diabetes blood glucose monitoring is also affected by the impact of precision thinking.Based on adequate assessment of various means of monitoring blood glucose,blood glucose monitoring is recommended from the self monitoring of the"point"blood sugar,to dynamically monitor the blood glucose change curve,and then to reflect the total blood glucose level of three months of glycosylated hemoglobin under the present stage.Future artificial pancreas technology will achieve accurate blood glucose management.%精准医学是在大数据时代提出的医疗模式,糖尿病血糖监测也受到精准思维的影响。充分评估血糖监测手段精准性基础上,现阶段血糖监测推荐从自我监测的“点”血糖,到动态监测血糖变化“曲线”,再到反映3个月总体血糖水平的糖化血红蛋白。未来人工胰腺技术将实现精准的血糖管理。

  12. On-line monitoring of dissolved gas-in-oil with FTIR spectra

    Institute of Scientific and Technical Information of China (English)

    Xianyong Liu; Yunluo Liu; Li Yue


    To overcome the disadvantages of conventional DGA (dissolved gas-in-oil) analysis using gas chromatography and other electrochemical sensors, initial researches were completed to realize on-line monitoring of dissolved gas-in-oil of power transformers using FTIR (Fourier Transform InfraRed) spectroscopy. Gas cell method is used to determine the characteristic absorption peaks of each diagnostic gas; simple and novel devices and procedures were designed in order to get measurable samples and spectra of mixed diagnostic gases with known concentration are taken using long optical path gas cell. The range of wavelength is estimated to be 3.0-13.9 μm from experimental spectra data. Hence the corresponding sampling frequency range should be in 536-4288 Hz and usable optical materials are suggested. It is concluded that a resolution of 10 cm-1 may well satisfy the monitoring of all diagnostic gases and water content except hydrogen, and the lowest detection limit may be as low as 2×l0-8 to acetylene with a 2.4-meter-long optical length.

  13. Monitoring off-gas O2/CO2 to predict nitrification performance in activated sludge processes. (United States)

    Leu, Shao-Yuan; Libra, Judy A; Stenstrom, Michael K


    Nitrification/denitrification (NDN) processes are the most widely used technique to remove nitrogenous pollutants from municipal wastewater. The performance of nitrogen removal in the NDN process depends on the metabolism of nitrifying bacteria, and is dependent on adequate oxygen supply. Off-gas testing is a convenient and popular method for measuring oxygen transfer efficiency (OTE) under process conditions and can be performed in real-time. Since carbon dioxide is produced by carbonaceous oxidizing organism and not by nitrifiers, it should be possible to use the off-gas carbon dioxide mole fraction to estimate nitrification performance independently of the oxygen uptake rate (OUR) or OTE. This paper used off-gas data with a dynamic model to estimate nitrifying efficiency for various activated sludge process conditions. The relationship among nitrification, oxygen transfer, carbon dioxide production, and pH change was investigated. Experimental results of an online off-gas monitoring for a full-scale treatment plant were used to validate the model. The results showed measurable differences in OUR and carbon dioxide transfer rate (CTR) and the simulations successfully predicted the effluent ammonia by using the measured CO(2) and O(2) contents in off-gas as input signal. Carbon dioxide in the off-gas could be a useful technique to control aeration and to monitor nitrification rate.

  14. Ambulatory Blood Pressure Monitoring in the Diagnosis and Treatment of Hypertension. (United States)

    Islam, Md Shahidul


    Clinicians should take initiatives to establish ambulatory blood pressure monitoring (ABPM) services in their own practice, or to ensure that they have access to such services elsewhere. Whenever possible, ABPM should be performed in suitable cases, where it is likely to deliver clinically useful information for making a correct diagnosis, or for tailoring the anti-hypertensive treatment regimen for each individual patient. ABPM is clinically useful, among others, for identifying people with "masked normotension", "masked hypertension", "sleep-time hypertension", and "reduced decline of sleep-time blood pressure". This review briefly outlines the rationales for the use of ABPM, interpretations of the ABPM-derived parameters, and the advantages of ABPM in decision making in the management of hypertension.

  15. An intelligent system for continuous blood pressure monitoring on remote multi-patients in real time

    CERN Document Server

    Marani, Roberto


    In this paper we present an electronic system to perform a non-invasive measurement of the blood pressure based on the oscillometric method, which does not suffer from the limitations of the well-known auscultatory one. Moreover the proposed system is able to evaluate both the systolic and diastolic blood pressure values and makes use of a microcontroller and a Sallen-Key active filter. With reference to other similar devices, a great improvement of our measurement system is achieved since it performs the transmission of the systolic and diastolic pressure values to a remote computer. This aspect is very important when the simultaneous monitoring of multi-patients is required. The proposed system, prototyped and tested at the Electron Devices Laboratory (Electrical and Information Engineering Department) of Polytechnic University of Bari, Italy, is characterized by originality, by plainness of use and by a very high level of automation (so called intelligent system).

  16. Collaborative Processing of Wearable and Ambient Sensor System for Blood Pressure Monitoring (United States)

    Nakamura, Masayuki; Nakamura, Jiro; Lopez, Guillaume; Shuzo, Masaki; Yamada, Ichiro


    This paper describes wireless wearable and ambient sensors that cooperate to monitor a person’s vital signs such as heart rate and blood pressure during daily activities. Each wearable sensor is attached on different parts of the body. The wearable sensors require a high sampling rate and time synchronization to provide a precise analysis of the received signals. The trigger signal for synchronization is provided by the ambient sensors, which detect the user’s presence. The Bluetooth and IEEE 802.15.4 wireless technologies are used for real-time sensing and time synchronization. Thus, this wearable health-monitoring sensor response is closely related to the context in which it is being used. Experimental results indicate that the system simultaneously provides information about the user’s location and vital signs, and the synchronized wearable sensors successfully measures vital signs with a 1 ms resolution. PMID:22163984

  17. Collaborative Processing of Wearable and Ambient Sensor System for Blood Pressure Monitoring

    Directory of Open Access Journals (Sweden)

    Ichiro Yamada


    Full Text Available This paper describes wireless wearable and ambient sensors that cooperate to monitor a person’s vital signs such as heart rate and blood pressure during daily activities. Each wearable sensor is attached on different parts of the body. The wearable sensors require a high sampling rate and time synchronization to provide a precise analysis of the received signals. The trigger signal for synchronization is provided by the ambient sensors, which detect the user’s presence. The Bluetooth and IEEE 802.15.4 wireless technologies are used for real-time sensing and time synchronization. Thus, this wearable health-monitoring sensor response is closely related to the context in which it is being used. Experimental results indicate that the system simultaneously provides information about the user’s location and vital signs, and the synchronized wearable sensors successfully measures vital signs with a 1 ms resolution.

  18. Ground gas monitoring: implications for hydraulic fracturing and CO2 storage. (United States)

    Teasdale, Christopher J; Hall, Jean A; Martin, John P; Manning, David A C


    Understanding the exchange of carbon dioxide (CO2) and methane (CH4) between the geosphere and atmosphere is essential for the management of anthropogenic emissions. Human activities such as carbon capture and storage and hydraulic fracturing ("fracking") affect the natural system and pose risks to future global warming and to human health and safety if not engineered to a high standard. In this paper an innovative approach of expressing ground gas compositions is presented, using data derived from regulatory monitoring of boreholes in the unsaturated zone at infrequent intervals (typically 3 months) with data from a high frequency monitoring instrument deployed over periods of weeks. Similar highly variable trends are observed for time scales ranging from decades to hourly for boreholes located close to sanitary landfill sites. Additionally, high frequency monitoring data confirm the effect of meteorological controls on ground gas emissions; the maximum observed CH4 and CO2 concentrations in a borehole monitored over two weeks were 40.1% v/v and 8.5% v/v respectively, but for 70% of the monitoring period only air was present. There is a clear weakness in current point monitoring strategies that may miss emission events and this needs to be considered along with obtaining baseline data prior to starting any engineering activity.

  19. Impact of antihypertensive combination and monotreatments on blood pressure variability: assessment by old and new indices. Data from a large ambulatory blood pressure monitoring database.

    LENUS (Irish Health Repository)

    Parati, Gianfranco


    High 24-h ambulatory blood pressure (ABP) variability is associated with poor cardiovascular outcomes. We analysed a large ABP monitoring database containing data from hypertensive patients treated with telmisartan\\/amlodipine combination or various monotherapies with the aim of quantifying the 24-h distribution of blood pressure (BP) reduction by treatment through the smoothness index and of developing and testing a new treatment-on-variability index (TOVI) to quantify the effects of treatment on both mean BP and BP variability.

  20. Enabling Technology for Monitoring & Predicting Gas Turbine Health & Performance in IGCC Powerplants

    Energy Technology Data Exchange (ETDEWEB)

    Kenneth A. Yackly


    The ''Enabling & Information Technology To Increase RAM for Advanced Powerplants'' program, by DOE request, was re-directed, de-scoped to two tasks, shortened to a 2-year period of performance, and refocused to develop, validate and accelerate the commercial use of enabling materials technologies and sensors for coal/IGCC powerplants. The new program was re-titled ''Enabling Technology for Monitoring & Predicting Gas Turbine Health & Performance in IGCC Powerplants''. This final report summarizes the work accomplished from March 1, 2003 to March 31, 2004 on the four original tasks, and the work accomplished from April 1, 2004 to July 30, 2005 on the two re-directed tasks. The program Tasks are summarized below: Task 1--IGCC Environmental Impact on high Temperature Materials: The first task was refocused to address IGCC environmental impacts on high temperature materials used in gas turbines. This task screened material performance and quantified the effects of high temperature erosion and corrosion of hot gas path materials in coal/IGCC applications. The materials of interest included those in current service as well as advanced, high-performance alloys and coatings. Task 2--Material In-Service Health Monitoring: The second task was reduced in scope to demonstrate new technologies to determine the inservice health of advanced technology coal/IGCC powerplants. The task focused on two critical sensing needs for advanced coal/IGCC gas turbines: (1) Fuel Quality Sensor to rapidly determine the fuel heating value for more precise control of the gas turbine, and detection of fuel impurities that could lead to rapid component degradation. (2) Infra-Red Pyrometer to continuously measure the temperature of gas turbine buckets, nozzles, and combustor hardware. Task 3--Advanced Methods for Combustion Monitoring and Control: The third task was originally to develop and validate advanced monitoring and control methods for coal/IGCC gas

  1. Research on coal-mine gas monitoring system controlled by annealing simulating algorithm (United States)

    Zhou, Mengran; Li, Zhenbi


    This paper introduces the principle and schematic diagram of gas monitoring system by means of infrared method. Annealing simulating algorithm is adopted to find the whole optimum solution and the Metroplis criterion is used to make iterative algorithm combination optimization by control parameter decreasing aiming at solving large-scale combination optimization problem. Experiment result obtained by the performing scheme of realizing algorithm training and flow of realizing algorithm training indicates that annealing simulating algorithm applied to identify gas is better than traditional linear local search method. It makes the algorithm iterate to the optimum value rapidly so that the quality of the solution is improved efficiently. The CPU time is shortened and the identifying rate of gas is increased. For the mines with much-gas gushing fatalness the regional danger and disaster advanced forecast can be realized. The reliability of coal-mine safety is improved.

  2. Use of Audible and Chart-recorded Ultrasonography to Monitor Fetal Heart Rate and Uterine Blood Flow Parameters in Cattle (United States)

    The objective of the present study was to evaluate the use of audible chart-recorded doppler ultrasonography (DUS) to monitor both uterine blood flow and fetal heart rate (FHR) during pregnancy in dairy cattle. Possible applications of DUS include the monitoring of fetal distress when a pregnancy be...

  3. Gas Bubble Disease Monitoring and Research of Juvenile Salmonids : Annual Report 1996.

    Energy Technology Data Exchange (ETDEWEB)

    Maule, Alec G.; Beeman, John W.; Hans, Karen M.; Mesa, M.G.; Haner, P.; Warren, J.J. [Geological Survey, Cook, WA (United States). Columbia River Research Lab.


    This document describes the project activities 1996--1997 contract year. This report is composed of three chapters which contain data and analyses of the three main elements of the project: field research to determine the vertical distribution of migrating juvenile salmonids, monitoring of juvenile migrants at dams on the Snake and Columbia rivers, and laboratory experiments to describe the progression of gas bubble disease signs leading to mortality. The major findings described in this report are: A miniature pressure-sensitive radio transmitter was found to be accurate and precise and, after compensation for water temperature, can be used to determine the depth of tagged-fish to within 0.32 m of the true depth (Chapter 1). Preliminary data from very few fish suggest that depth protects migrating juvenile steelhead from total dissolved gas supersaturation (Chapter 1). As in 1995, few fish had any signs of gas bubble disease, but it appeared that prevalence and severity increased as fish migrated downstream and in response to changing gas supersaturation (Chapter 2). It appeared to gas bubble disease was not a threat to migrating juvenile salmonids when total dissolved gas supersaturation was < 120% (Chapter 2). Laboratory studies suggest that external examinations are appropriate for determining the severity of gas bubble disease in juvenile salmonids (Chapter 3). The authors developed a new method for examining gill arches for intravascular bubbles by clamping the ventral aorta to reduce bleeding when arches were removed (Chapter 3). Despite an outbreak of bacterial kidney disease in the experimental fish, the data indicate that gas bubble disease is a progressive trauma that can be monitored (Chapter 3).

  4. Effect of caffeine citrate on the blood gas indexes in newborns with apnea

    Institute of Scientific and Technical Information of China (English)

    Chun-Yan Wu; Xiao-Jiao Wang; Yuan-Yuan Wang


    Objective:To explore the effect of caffeine citrate on the blood gas indexes in newborns with apnea.Methods: A total of 108 primary premature infants diagnosed with apnea were included in the study and randomized into the caffeine citrate treatment group and the aminophylline control group with 54 cases in each group. The apnea episode duration 72 h after medication, and the blood gas before medication and 24, 48, 72 h after medication between the two groups were compared.Results: The apnea episode duration 24, 48, 72 h after medication in the treatment group was significantly shorter than that in the control group. PaO2 24, 48, 72 h after medication in the treatment group was significantly higher than that in the control group, while PaCO2 was significantly reduced when compared with the control group.Conclusions:Caffeine citrate has achieved a significantly clinical effect in the treatment of newborn apnea, as a new therapeutic drug, is worthy of being widely recommended in the clinic.

  5. Designing and Constructing Blood Flow Monitoring System to Predict Pressure Ulcers on Heel

    Directory of Open Access Journals (Sweden)

    Akbari H.


    Full Text Available Background: A pressure ulcer is a complication related to the need for the care and treatment of primarily disabled and elderly people. With the decrease of the blood flow caused by the pressure loaded, ulcers are formed and the tissue will be wasted with the passage of time. Objective: The aim of this study was to construct blood flow monitoring system on the heel tissue which was under external pressure in order to evaluate the tissue treatment in the ulcer. Methods: To measure the blood flow changes, three infrared optical transmitters were used at the distances of 5, 10, and 15 mm to the receiver. Blood flow changes in heels were assessed in pressures 0, 30, and 60 mmHg. The time features were extracted for analysis from the recorded signal by MATLAB software. Changes of the time features under different pressures were evaluated at the three distances by ANOVA in SPSS software. The level of significance was considered at 0.05. Results: In this study, 15 subjects, including both male and female, with the mean age of 54±7 participated. The results showed that the signal amplitude, power and absolute signal decreased significantly when pressure on the tissue increased in different layers (p<0.05. Heart rate only decreased significantly in pressures more than 30 mmHg (p=0.02. In pressures more than 30 mmHg, in addition to a decrease in the time features, the pattern of blood flow signal changed and it wasn’t the same as noload signal. Conclusion: By detecting the time features, we can reach an early diagnosis to prognosticate the degeneration of the tissue under pressure and it can be recommended as a method to predict bedsores in the heel.

  6. Performance Evaluation and Labeling Comprehension of a New Blood Glucose Monitoring System with Integrated Information Management (United States)

    List, Susan M; Starks, Nykole; Baum, John; Greene, Carmine; Pardo, Scott; Parkes, Joan L; Schachner, Holly C; Cuddihy, Robert


    Background This study evaluated performance and product labeling of CONTOUR® USB, a new blood glucose monitoring system (BGMS) with integrated diabetes management software and a universal serial bus (USB) port, in the hands of untrained lay users and health care professionals (HCPs). Method Subjects and HCPs tested subject's finger stick capillary blood in parallel using CONTOUR USB meters; deep finger stick blood was tested on a Yellow Springs Instruments (YSI) glucose analyzer for reference. Duplicate results by both subjects and HCPs were obtained to assess system precision. System accuracy was assessed according to International Organization for Standardization (ISO) 15197:2003 guidelines [within ±15 mg/dl of mean YSI results (samples <75 mg/dl) and ±20% (samples ≥75 mg/dl)]. Clinical accuracy was determined by Parkes error grid analysis. Subject labeling comprehension was assessed by HCP ratings of subject proficiency. Key system features and ease-of-use were evaluated by subject questionnaires. Results All subjects who completed the study (N = 74) successfully performed blood glucose measurements, connected the meter to a laptop computer, and used key features of the system. The system was accurate; 98.6% (146/148) of subject results and 96.6% (143/148) of HCP results exceeded ISO 15197:2003 criteria. All subject and HCP results were clinically accurate (97.3%; zone A) or associated with benign errors (2.7%; zone B). The majority of subjects rated features of the BGMS as “very good” or “excellent.” Conclusions CONTOUR USB exceeded ISO 15197:2003 system performance criteria in the hands of untrained lay users. Subjects understood the product labeling, found the system easy to use, and successfully performed blood glucose testing. PMID:22027308

  7. [A new method for the transcutaneous measurement of deep body temperature during anaesthesia and intensive care (author's transl)]. (United States)

    Jost, U; Hanf, K; Köhler, C O; Just, O H


    A new method for monitoring deep body temperature is described. It is based on the establishment, by means of electronic appliances, of a zone without heatflow from the deep tissues. The method is simple and the results compare favourably with those obtained by other procedures for measuring core temperature. The uses of this transcutaneous mehtod are discussed and its advantages and reliability in the operating theatre and intensive care unit are emphasized. It becomes less reliable if it is employed during and after extracorporeal circulation in hypothermia on account of the temperature gradient.

  8. Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies: a proof of concept trial. (United States)

    Stefan, Hermann; Kreiselmeyer, Gernot; Kerling, Frank; Kurzbuch, Katrin; Rauch, Christophe; Heers, Marcel; Kasper, Burkhard S; Hammen, Thilo; Rzonsa, Martina; Pauli, Elisabeth; Ellrich, Jens; Graf, Wolfgang; Hopfengärtner, Rüdiger


    To elucidate, in a pilot-study, whether noninvasive transcutaneous vagus nerve stimulation (t-VNS) is a safe and tolerable alternative treatment option in pharmacoresistant epilepsy. t-VNS was applied to 10 patients with pharmacoresistant epilepsies. Stimulation via the auricular branch of the vagus nerve of the left tragus was delivered three times per day for 9 months. Subjective documentation of stimulation effects was obtained from patients' seizure diaries. For a more reliable assessment of seizure frequency, we carried out prolonged outpatient video-electroencephalography (EEG) monitoring. In addition, computerized testing of cognitive, affective, and emotional functions was performed. Three patients aborted the study. Of the remaining seven patients, an overall reduction of seizure frequency was observed in five patients after 9 months of t-VNS. The noninvasive t-VNS stimulation is a safe and well-tolerated method for relatively long periods, and might be an alternative treatment option for patients with epilepsy.

  9. Continued Development of Compact Multi-gas Monitor for Life Support Systems Control in Space (United States)

    Delgado-Alonso, Jesús; Phillips, Straun; Chullen, Cinda; Quinn, Gregory


    Miniature optic gas sensors (MOGS) based on luminescent materials have shown great potential as alternatives to Near-Infrared-based gas sensor systems for the advanced space suit portable life support system (PLSS). The unique capability of MOGS for carbon dioxide and oxygen monitoring under wet conditions has been reported, as has the fast recovery of MOGS humidity sensors after long periods of being wet. Lower volume and power requirements are also potential advantages of MOGS over both traditional and advanced Non-Dispersive Infrared (NDIR) gas sensors, which have shown so far longer life than luminescent sensors. This paper presents the most recent results in the development and analytical validation of a compact multi-gas sensor unit based on luminescent sensors for the PLSS. Results of extensive testing are presented, including studies conducted at Intelligent Optical Systems laboratories, a United Technology Corporation Aerospace Systems (UTAS) laboratory, and a Johnson Space Center laboratory. The potential of this sensor technology for gas monitoring in PLSSs and other life support systems and the advantages and limitations found through detailed sensor validation are discussed.

  10. Transcutaneous Noninvasive Device for the Responsive Delivery of Melatonin in Microgravity. Project (United States)

    National Aeronautics and Space Administration — Our goal is develop a smart, transcutaneous device for individualized circadian (sleep) therapy by responsive release of melatonin, in microgravity. Additionally,...

  11. Assessment of transcutaneous vaccine delivery by optical coherence tomography Assessment of transcutaneous vaccine delivery by OCT (United States)

    Kamali, T.; Doronin, A.; Rattanapak, T.; Hook, S.; Meglinski, I.


    Immunization is one of the most efficient and cost-effective means for the prevention of diseases. The latest trend for inducing protective immunity is topical application of vaccines to intact skin rather than invasive administration via injection. Apart from being a non-invasive route of drug delivery, skin itself also offers advantages through the presence of cells of the immune system in both the dermis and epidermis. However, vaccine penetration through the outermost layers of skin is limited by the barrier provided by the Stratum corneum. In the current study utilizing conventional Optical Coherence Tomography (OCT) we investigate the transcutaneous delivery of a nano- particulate peptide vaccine into mouse skin in vivo. We demonstrate that a front of molecular diffusion within the skin can be clearly observed by using cross-correlations of successive 2D OCT images. Thus, OCT provides a unique tool for quantitative assessment of dynamics of diffusion of drugs, target compounds, analytes, cosmetics and various chemical agents in biological tissues in vivo.

  12. Continuous intra-arterial blood pH monitoring in rabbits with acid-base disorders. (United States)

    Jin, Weizhong; Jiang, Jinjun; Wang, Xun; Zhu, Xiaodan; Wang, Guifang; Song, Yuanlin; Bai, Chunxue


    The acid-base balance of arterial blood is important for the clinical management of seriously ill patients, especially patients with acute lung injury or acute respiratory distress syndrome. We developed a novel fluorosensor for continuous blood pH monitoring and evaluated its performance both in vitro and in vivo in rabbits with acid-base disorders. The pH sensor is made of N-allyl-4-piperazinyl-1, 8-napthalimide and 2-hydroxyethyl methacrylate, which were bonded at the distal end of the optical fiber. The fluorescence intensity increased as the pH decreased with good reproducibility, selectivity and linearity in the pH range of 6-8. The pH measurement precision was 0.03 ± 0.03 pH units with a bias of -0.02 ± 0.04 (n = 105) and -0.00 ± 0.05 pH units (n=189) in rabbits with metabolic and respiratory acid-base orders, respectively. The optical pH sensor can accurately measure pH fluctuations with a fast response and is a promising candidate for continuous in-line measurements of blood pH in critical care patients.

  13. [Ambulatory blood pressure monitoring is a useful tool for all patients]. (United States)

    de la Sierra, A

    Clinical blood pressure measurement (BP) is an occasional and imperfect way of estimating this biological variable. Ambulatory blood pressure monitoring (ABPM) is by far the best clinical tool for measuring an individual's blood pressure. Mean values over 24h, through the daytime and at night all make it more possible to predict organic damage and the future development of the disorder. ABPM enables the detection of white-coat hypertension and masked hypertension in both the diagnosis and follow-up of treated patients. Although some of the advantages of ABPM can be reproduced by more automated measurement without the presence of an observer in the clinic or self-measurement at home, there are some other elements of great interest that are unique to ABPM, such as seeing what happens to a patient's BP at night, the night time dipping pattern and short-term variability, all of which relate equally to the patient's prognosis. There is no scientific or clinical justification for denying these advantages, and ABPM should form part of the evaluation and follow-up of practically all hypertensive patients. Rather than continuing unhelpful discussions as to its availability and acceptability, we should concentrate our efforts on ensuring its universal availability and clearly explaining its advantages to both doctors and patients.

  14. Modelling, verification, and calibration of a photoacoustics based continuous non-invasive blood glucose monitoring system. (United States)

    Pai, Praful P; Sanki, Pradyut K; Sarangi, Satyabrata; Banerjee, Swapna


    This paper examines the use of photoacoustic spectroscopy (PAS) at an excitation wavelength of 905 nm for making continuous non-invasive blood glucose measurements. The theoretical background of the measurement technique is verified through simulation. An apparatus is fabricated for performing photoacoustic measurements in vitro on glucose solutions and in vivo on human subjects. The amplitude of the photoacoustic signals measured from glucose solutions is observed to increase with the solution concentration, while photoacoustic amplitude obtained from in vivo measurements follows the blood glucose concentration of the subjects, indicating a direct proportionality between the two quantities. A linear calibration method is applied separately on measurements obtained from each individual in order to estimate the blood glucose concentration. The estimated glucose values are compared to reference glucose concentrations measured using a standard glucose meter. A plot of 196 measurement pairs taken over 30 normal subjects on a Clarke error grid gives a point distribution of 82.65% and 17.35% over zones A and B of the grid with a mean absolute relative deviation (MARD) of 11.78% and a mean absolute difference (MAD) of 15.27 mg/dl (0.85 mmol/l). The results obtained are better than or comparable to those obtained using photoacoustic spectroscopy based methods or other non-invasive measurement techniques available. The accuracy levels obtained are also comparable to commercially available continuous glucose monitoring systems.

  15. System Accuracy Evaluation of the GlucoRx Nexus Voice TD-4280 Blood Glucose Monitoring System

    Directory of Open Access Journals (Sweden)

    Muhammad Khan


    Full Text Available Use of blood glucose (BG meters in the self-monitoring of blood glucose (SMBG significantly lowers the risk of diabetic complications. With several BG meters now commercially available, the International Organization for Standardization (ISO ensures that each BG meter conforms to a set degree of accuracy. Although adherence to ISO guidelines is a prerequisite for commercialization in Europe, several BG meters claim to meet the ISO guidelines yet fail to do so on internal validation. We conducted a study to determine whether the accuracy of the GlucoRx Nexus TD-4280 meter, utilized by our department for its cost-effectiveness, complied with ISO guidelines. 105 patients requiring laboratory blood glucose analysis were randomly selected and reference measurements were determined by the UniCel DxC 800 clinical system. Overall the BG meter failed to adhere to the ≥95% accuracy criterion required by both the 15197:2003 (overall accuracy 92.4% and 15197:2013 protocol (overall accuracy 86.7%. Inaccurate meters have an inherent risk of over- and/or underestimating the true BG concentration, thereby risking patients to incorrect therapeutic interventions. Our study demonstrates the importance of internally validating the accuracy of BG meters to ensure that its accuracy is accepted by standardized guidelines.

  16. Effect of training on the performance of blood glucose monitoring using a reagent strip (Glucoprofil). (United States)

    Chantelau, E; Starostina, E G; Antsiferov, M B


    A relatively simple, new test-strip for blood-glucose monitoring, the Glucoprofil strip with a reaction-zone of film-foil, was evaluated by testing 100 different blood glucose concentrations between 2.1 and 29.7 mmol/l. The results were obtained visually before and after training to read the color changes of the strip according to the scale on the strip-container. Plasma glucose measurements with the Beckman Glucose-Analyzer were used for reference. The results show that the Glucoprofil-strip readings correlated well with the reference method (r = 0.97), thorough training provided. The mean deviation of the strip results was less than 1 mmol/l. Similar results were obtained using another blood glucose strip, the Haemoglukotest 20-800 R. Our study indicates that the performance of the Glucoprofil strip is satisfactory, and hence the strip may be useful for clinical purposes. Consistent with previous reports we could demonstrate that training improved the reading results of the Glucoprofil strip.

  17. Self-monitoring of blood glucose in noninsulin-treated type 2 diabetes: an overview

    Directory of Open Access Journals (Sweden)

    Nanne Kleefstra


    Full Text Available Nanne Kleefstra1, Johanna Hortensius1, Kornelis JJ van Hateren1, Susan JJ Logtenberg1, Sebastiaan T Houweling2, Rijk OB Gans3, Henk JG Bilo11Diabetes Centre, Isala Clinics, Zwolle, The Netherlands; 2Langerhans Medical Research Group, The Netherlands; 3Department of Internal Medicine, University Medical Center Groningen, Groningen, The NetherlandsIntroduction: The effectiveness of self-monitoring of blood glucose (SMBG in noninsulin-treated patients with type 2 diabetes (T2DM remains unclear. We aimed to review the trials investigating the effects of SMBG in this population.Methods: Medline was searched until June 29, 2009. Randomized controlled trials (RCTs of at least 12 weeks’ duration were included. Data on the following aspects were gathered: patient and study characteristics, effects on HbA1c, quality of life and treatment satisfaction, and methodological quality.Results: The search revealed 9 original RCTs. These studies were very heterogeneous, and 5 were classified as of high quality. The studies with the best methodology did not show an effect of SMBG on HbA1c, the studies with the worst methodological quality did. Two out of the 4 studies that assessed quality of life showed a significant change in favor of the control group, 1 study showed a significant change in favor of SMBG.Discussion and conclusion: We found an inverse relation between study quality and efficacy of SMBG. At this moment, there is no basis for general use of SMBG in noninsulin-treated T2DM patients.Keywords: blood glucose self-monitoring, diabetes mellitus, type 2, blood glucose, hemoglobin A, glycosylated

  18. Unraveling fabrication and calibration of wearable gas monitor for use under free-living conditions. (United States)

    Yue Deng; Cheng Chen; Tsow, Francis; Xiaojun Xian; Forzani, Erica


    Volatile organic compounds (VOC) are organic chemicals that have high vapor pressure at regular conditions. Some VOC could be dangerous to human health, therefore it is important to determine real-time indoor and outdoor personal exposures to VOC. To achieve this goal, our group has developed a wearable gas monitor with a complete sensor fabrication and calibration protocol for free-living conditions. Correction factors for calibrating the sensors, including sensitivity, aging effect, and temperature effect are implemented into a Quick Response Code (QR code), so that the pre-calibrated quartz tuning fork (QTF) sensor can be used with the wearable monitor under free-living conditions.

  19. Design and performance of a skid-mounted portable compartment fire gas furnace and monitoring system

    Directory of Open Access Journals (Sweden)

    Mueller K.


    Full Text Available A custom, portable natural gas fire furnace was designed and constructed for use at the University of Notre Dame to experimentally investigate the out-of-plane behavior of full-scale reinforced concrete (RC bearing walls under fire. The unique aspects of this furnace allowed the application of large mechanical loads and non-contact optical response monitoring to be done while subjecting the wall to elevated temperatures. The performance of the experimental furnace, mechanical loading, and response monitoring system is reported using the results from the first two RC wall test specimens.

  20. Blood gas analysis of patients with malignant ascites in 42 cases%恶性腹水患者42例血气分析

    Institute of Scientific and Technical Information of China (English)

    谭斌; 辛瑞娟; 陈慧; 冯雅宁; 白飞虎


    Objective:To explore the clinical significance of blood gas analysis indexes of patients with malignant ascites.Methods:The blood gas parameters of the malignant ascites group and the healthy control group were detected by using automatic blood gas analyzer.The blood sodium(Na+),the blood chlorine(Cl-) concentration were detected in the venous blood.Results:pH value,PCO2, PO2 and HCO3- of the malignant ascites group were compared with those of the control group,and the differences were all statistically significant(P<0.05).The incidence rate of hypoxemia in the malignant ascites group was 69.0%,the incidence rate of acid-base imbalance was 66.7%,the acid-base imbalance was give priority to with simple respiratory alkalosis,the incidence rate was 44.89%.Conclusion:Patients with malignant ascites easily have acid-base imbalance and hypoxia,the acid-base imbalance is give priority to with respiratory alkalosis.It should monitor the blood gas analysis in a timely manner and give timely symptomatic treatment to improve the life quality of the patients.%目的:探讨恶性腹水患者血气分析指标的临床意义。方法:采用全自动血气分析仪检测恶性腹水组和健康对照组血气参数,静脉血测定血钠(Na+)、血氯(Cl-)浓度。结果:恶性腹水组pH值、PCO2、PO2和HCO3-与对照组比较,差异均有统计学意义。恶性腹水组低氧血症的发生率69.0%,酸碱失衡的发生率66.7%,酸碱失衡以单纯性呼吸性碱中毒为主,发生率44.89%。结论:恶性腹水患者易发生酸碱失衡及低氧血症,酸碱失衡以呼吸性碱中毒为主,应及时进行血气分析,及时对症治疗,提高患者生活质量。

  1. Limitations of stroke volume estimation by non-invasive blood pressure monitoring in hypergravity.

    Directory of Open Access Journals (Sweden)

    Olivier Manen

    Full Text Available Altitude and gravity changes during aeromedical evacuations induce exacerbated cardiovascular responses in unstable patients. Non-invasive cardiac output monitoring is difficult to perform in this environment with limited access to the patient. We evaluated the feasibility and accuracy of stroke volume estimation by finger photoplethysmography (SVp in hypergravity.Finger arterial blood pressure (ABP waveforms were recorded continuously in ten healthy subjects before, during and after exposure to +Gz accelerations in a human centrifuge. The protocol consisted of a 2-min and 8-min exposure up to +4 Gz. SVp was computed from ABP using Liljestrand, systolic area, and Windkessel algorithms, and compared with reference values measured by echocardiography (SVe before and after the centrifuge runs.The ABP signal could be used in 83.3% of cases. After calibration with echocardiography, SVp changes did not differ from SVe and values were linearly correlated (p<0.001. The three algorithms gave comparable SVp. Reproducibility between SVp and SVe was the best with the systolic area algorithm (limits of agreement -20.5 and +38.3 ml.Non-invasive ABP photoplethysmographic monitoring is an interesting technique to estimate relative stroke volume changes in moderate and sustained hypergravity. This method may aid physicians for aeronautic patient monitoring.

  2. Optical Multi-Gas Monitor Technology Demonstration on the International Space Station (United States)

    Pilgrim, Jeffrey S.; Wood, William R.; Casias, Miguel E.; Vakhtin, Andrei B,; Johnson, Michael D.; Mudgett, Paul D.


    There are a variety of both portable and fixed gas monitors onboard the International Space Station (ISS). Devices range from rack-mounted mass spectrometers to hand-held electrochemical sensors. An optical Multi-Gas Monitor has been developed as an ISS Technology Demonstration to evaluate long-term continuous measurement of 4 gases. Based on tunable diode laser spectroscopy, this technology offers unprecedented selectivity, concentration range, precision, and calibration stability. The monitor utilizes the combination of high performance laser absorption spectroscopy with a rugged optical path length enhancement cell that is nearly impossible to misalign. The enhancement cell serves simultaneously as the measurement sampling cell for multiple laser channels operating within a common measurement volume. Four laser diode based detection channels allow quantitative determination of ISS cabin concentrations of water vapor (humidity), carbon dioxide, ammonia and oxygen. Each channel utilizes a separate vertical cavity surface emitting laser (VCSEL) at a different wavelength. In addition to measuring major air constituents in their relevant ranges, the multiple gas monitor provides real time quantitative gaseous ammonia measurements between 5 and 20,000 parts-per-million (ppm). A small ventilation fan draws air with no pumps or valves into the enclosure in which analysis occurs. Power draw is only about 3 W from USB sources when installed in Nanoracks or when connected to 28V source from any EXPRESS rack interface. Internal battery power can run the sensor for over 20 hours during portable operation. The sensor is controlled digitally with an FPGA/microcontroller architecture that stores data internally while displaying running average measurements on an LCD screen and interfacing with the rack or laptop via USB. Design, construction and certification of the Multi-Gas Monitor were a joint effort between Vista Photonics, Nanoracks and NASA-Johnson Space Center (JSC

  3. [New routes of administration: epidermal, transcutaneous mucosal ways of vaccination]. (United States)

    Denis, François; Alain, Sophie; Ploy, Marie-Cécile


    A successful vaccine triggers the interaction of various cells of the immune system as does a regular immune response. It is thus necessary to introduce the vaccine antigens into an anatomic site where they will contact immune cells. The route of administration is thus critical for the outcome of vaccination. Intramuscular or subcutaneous injections are the most popular. Antigens injected intramuscularly can form persistent precipitates that are dissolved and re-absorbed relatively slowly. If injecting antigens is a quick, easy and reproducible way to vaccination, it requires trained personnel. Alternatives exist, through non-invasive formulations which allow administration by the patient or a third party with no particular expertise. The skin, especially its epidermal layer, is an accessible and competent immune environment and an attractive target for vaccine delivery, through transcutaneous delivery or immunostimulant patches. Mucosal immunization is another strategy: its major rationale is that organisms invade the body via mucosal surfaces. Therefore, local protection at mucosal surface as well as systemic defense is beneficial. Various formulations of mucosal vaccines have been developed, such as the Sabin oral polio vaccine (OPV), rotavirus vaccines, cold-adapted influenza vaccines or vaccine against typhoid fever. Thus we are entering in an era where mucosal and transcutaneous immunisation will play an important role in disease management. However, it has not been so easy to obtain regulatory approval for mucosal or transcutaneous formulations and needle-based vaccines continue to dominate the market.

  4. A plunger lift and monitoring system for gas wells based on deployment-retrievement integration

    Directory of Open Access Journals (Sweden)

    Zheng Tong


    Full Text Available As a necessary step, removing liquid in the wellbore plays an important role during the production of gas wells. Plunger lift is a widely-used intermittent deliquification process for gas wells. However, the manual control way and wire logging are still utilized as a downhole monitoring way for plunger lift, which is not efficient in terms of interrupting the production. This paper presents an improved solution that logging instruments canister are deployed and retrieved by means of a new assembly. With the reciprocating plunger, logging instruments canister can be carried and deployed to the bottom of a gas well to carry out logging and sampling tasks on the production demand of a field. After the deployment and logging tasks are performed, logging instruments canister is carried back to the surface by the plunger and then data is transferred to the wellhead device near field wireless communication technology. This newly developed plunger lift system comprises plunger body, deployment sub-assembly, retrieve sub-assembly and logging instruments canister. The surface device comprises RF antenna, reader and writer. Based upon the method of deployment-retrieve integration, the new deliquification process is introduced and on-line monitoring of production dynamics can be performed including P/T measurement, downhole fluid sampling, pressure build-up, etc. without interrupting production. The general solution and engineering design parameters have been confirmed by research teams, while system prototype manufacture and workbench tests are being performed. The cost-effective way combining deliquification with dynamic monitoring is developed and contributes to increasing production and the stable productivity of gas wells. It is very significant for low-pressure and low-production gas fields to achieve automation production and management.

  5. Laser Spectroscopy Multi-Gas Monitor: Results of Technology Demonstration on ISS (United States)

    Mudgett, Paul D.; Pilgrim, Jeffrey S.


    Tunable diode laser spectroscopy (TDLS) is an up and coming trace and major gas monitoring technology with unmatched selectivity, range and stability. The technology demonstration of the 4 gas Multi-Gas Monitor (MGM), reported at the 2014 ICES conference, operated continuously on the International Space Station (ISS) for nearly a year. The MGM is designed to measure oxygen, carbon dioxide, ammonia and water vapor in ambient cabin air in a low power, relatively compact device. While on board, the MGM experienced a number of challenges, unplanned and planned, including a test of the ammonia channel using a commercial medical ammonia inhalant. Data from the unit was downlinked once per week and compared with other analytical resources on board, notably the Major Constituent Analyzer (MCA), a magnetic sector mass spectrometer. MGM spent the majority of the time installed in the Nanoracks Frame 2 payload facility in front breathing mode (sampling the ambient environment of the Japanese Experiment Module), but was also used to analyze recirculated rack air. The capability of the MGM to be operated in portable mode (via internal rechargeable lithium ion polymer batteries or by plugging into any Express Rack 28VDC connector) was a part of the usability demonstration. Results to date show unprecedented stability and accuracy of the MGM vs. the MCA for oxygen and carbon dioxide. The ammonia challenge (approx. 75 ppm) was successful as well, showing very rapid response time in both directions. Work on an expansion of capability in a next generation MGM has just begun. Combustion products and hydrazine are being added to the measurable target analytes. An 8 to 10 gas monitor (aka Gas Tricorder 1.0) is envisioned for use on ISS, Orion and Exploration missions.

  6. Optical Multi-Gas Monitor Technology Demonstration on the International Space Station (United States)

    Pilgrim, Jeffrey S.; Wood, William R.; Casias, Miguel E.; Vakhtin, Andrei B.; Johnson, Michael D.; Mudgett, Paul D.


    The International Space Station (ISS) employs a suite of portable and permanently located gas monitors to insure crew health and safety. These sensors are tasked with functions ranging from fixed mass spectrometer based major constituents analysis to portable electrochemical sensor based combustion product monitoring. An all optical multigas sensor is being developed that can provide the specificity of a mass spectrometer with the portability of an electrochemical cell. The technology, developed under the Small Business Innovation Research program, allows for an architecture that is rugged, compact and low power. A four gas version called the Multi-Gas Monitor was launched to ISS in November 2013 aboard Soyuz and activated in February 2014. The portable instrument is comprised of a major constituents analyzer (water vapor, carbon dioxide, oxygen) and high dynamic range real-time ammonia sensor. All species are sensed inside the same enhanced path length optical cell with a separate vertical cavity surface emitting laser (VCSEL) targeted at each species. The prototype is controlled digitally with a field-programmable gate array/microcontroller architecture. The optical and electronic approaches are designed for scalability and future versions could add three important acid gases and carbon monoxide combustion product gases to the four species already sensed. Results obtained to date from the technology demonstration on ISS are presented and discussed.

  7. High-Density Fiber Optical Sensor and Instrumentation for Gas Turbine Operation Condition Monitoring

    Directory of Open Access Journals (Sweden)

    Hua Xia


    Full Text Available Gas turbine operation control is normally based on thermocouple-measured exhaust temperatures. Due to radiation shielding and bulky package, it is difficult to provide high spatial resolution for measuring can-to-can combustion temperature profile at the exhaust duct. This paper has demonstrated that wavelength-division-multiplexing-based fiber Bragg grating sensors could provide high spatial resolution steady and dynamic temperature measurements. A robust sensor package can be designed with either circumferential sensing cable or radial sensing rake for quasi-distributing multiple fiber sensors in the gas turbine environment. The field validations have demonstrated that quasi-distributed fiber sensors have not only demonstrated its temperature measurement accuracy compared to existing thermocouple sensors but also shown its unique dynamic response amplitude and power spectra that could be utilized for gas turbine transient operation condition monitoring and diagnostics.

  8. Blood (United States)

    ... Also, blood is either Rh-positive or Rh-negative. So if you have type A blood, it's either A positive or A negative. Which type you are is important if you need a blood transfusion. And your Rh factor could be important ...

  9. Development of an online biosensor for in situ monitoring of chlorine dioxide gas disinfection efficacy

    Energy Technology Data Exchange (ETDEWEB)

    Del Busto-Ramos, M.; Budzik, M.; Corvalan, C.; Morgan, M.; Nivens, D.; Applegate, B. [Purdue Univ., West Lafayette, IN (United States). Dept. of Food Science; Turco, R. [Purdue Univ., West Lafayette, IN (United States). Dept. of Agronomy


    A prototype bioluminescence-based biosensor was designed and constructed to evaluate the antimicrobial efficacy of chlorine dioxide (ClO{sub 2}) gas under various treatment conditions. The biosensor consisted of a bioluminescent bioreporter (Pseudomonas fluorescens 5RL), an optical transducer (photomultiplier tube), and a light-tight chamber housing, the bioreporter and the transducer. The bioluminescent recombinant P. fluorescens 5RL in the biosensor allowed for online monitoring of bioluminescence during ClO{sub 2} gas disinfection. Experiments were performed to evaluate the effects of the two key physical parameters associated with ClO{sub 2} disinfection: relative humidity (40, 60, 80%) and ClO{sub 2} gas concentration (0.5, 1.0, 1.6, 2.1 mg/l) on the bioreporter. Results showed that increasing concentrations of ClO{sub 2} gas corresponded to a faster decrease in luminescence. The rates of luminescence decrease from P. fluorescens 5RL, and the log reduction time (LRT, time required to obtain 1-log reduction in luminescence) were calculated for each treatment tested. The LRT values of luminescence were 103, 78, 53, and 35 s for 0.5, 1.0, 1.6, and 2.1 mg/l of ClO{sub 2} gas treatment, respectively, at 78% relative humidity. The gas concentration which caused a tenfold change in LRT (z value) for luminescence of P. fluorescens 5RL was 3.4 mg/l of ClO{sub 2}. The prototype biosensor showed potential for many applications, such as monitoring real-time microbial inactivation and understanding parameters that influence the efficacy of gaseous decontamination procedures. (orig.)

  10. NDIR Gas Sensor for Spatial Monitoring of Carbon Dioxide Concentrations in Naturally Ventilated Livestock Buildings

    Directory of Open Access Journals (Sweden)

    Luciano B. Mendes


    Full Text Available The tracer gas ratio method, using CO2 as natural tracer, has been suggested as a pragmatic option to measure emissions from naturally ventilated (NV barns without the need to directly estimate the ventilation rate. The aim of this research was to assess the performance of a low-cost Non-Dispersive Infra-Red (NDIR sensor for intensive spatial field monitoring of CO2 concentrations in a NV dairy cow house. This was achieved by comparing NDIR sensors with two commonly applied methods, a Photo-Acoustic Spectroscope (PAS Gas Monitor and an Open-Path laser (OP-laser. First, calibrations for the NDIR sensors were obtained in the laboratory. Then, the NDIR sensors were placed in a dairy cow barn for comparison with the PAS and OP-laser methods. The main conclusions were: (a in order to represent the overall barn CO2 concentration of the dairy cow barn, the number of NDIR sensors to be accounted for average concentration calculation was dependent on barn length and on barn area occupation; and (b the NDIR CO2 sensors are suitable for multi-point monitoring of CO2 concentrations in NV livestock barns, being a feasible alternative for the PAS and the OP-laser methods to monitor single-point or averaged spatial CO2 concentrations in livestock barns.

  11. Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

    Energy Technology Data Exchange (ETDEWEB)

    Deborah L. Layton; Kimberly Frerichs


    The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and the results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).

  12. Idaho National Laboratory (INL) Site Greenhouse Gas (GHG) Monitoring Plan - 40 CFR 98

    Energy Technology Data Exchange (ETDEWEB)

    Deborah L. Layton; Kimberly Frerichs


    The purpose of this Greenhouse Gas (GHG) Monitoring Plan is to meet the monitoring plan requirements of Title 40 of the Code of Federal Regulations Part 98.3(g)(5). This GHG Monitoring Plan identifies procedures and methodologies used at the Idaho National Laboratory Site (INL Site) to collect data used for GHG emissions calculations and reporting requirements from stationary combustion and other regulated sources in accordance with 40 CFR 98, Subparts A and other applicable subparts. INL Site Contractors determined subpart applicability through the use of a checklist (Appendix A). Each facility/contractor reviews operations to determine which subparts are applicable and the results are compiled to determine which subparts are applicable to the INL Site. This plan is applicable to the 40 CFR 98-regulated activities managed by the INL Site contractors: Idaho National Laboratory (INL), Idaho Cleanup Project (ICP), Advanced Mixed Waste Treatment Project (AMWTP), and Naval Reactors Facilities (NRF).

  13. Effect of breath-hold on blood gas analysis in captive Pacific white-sided dolphins (Lagenorhynchus obliquidens). (United States)

    Terasawa, Fumio; Ohizumi, Hiroshi; Ohshita, Isao


    The effect of a breath-hold on blood gas was evaluated in captive Pacific white-sided dolphins (Lagenorhynchus obliquidens). Serial blood collections were performed from a vessel on the ventral surface of the flukes during breath-hold. In total, 178 blood samples were taken from three dolphins for five trials in each animal. During a breath-hold, partial pressure of oxygen (Po₂) decreased from 152.5 to 21.8 mmHg and partial pressure of carbon dioxide (Po₂) conversely increased from 31.8 to 83.6 mmHg. The range of pH was 7.54 to 7.25, suggesting drastic change from alkalemia to acidemia. These wide ranges of blood gas imply a considerable change of oxygen affinity caused by the Bohr effect during breath-hold, which enable effective uptake and distribution of oxygen to metabolizing tissues.

  14. Application of Ambulatory Blood Pressure Monitoring Essential Hypertension with Target-Organ Damage

    Institute of Scientific and Technical Information of China (English)


    @@The purpose of this study was to determine whether this normal ambulatory blood pressure (ABP) criterion deter-mined by JVC-VI was suitable for Chinese patients with es-sential hypertention (EH), in order to decrease target organ damage (TOD). 24-hour ABP monitoring (ABPM) results in 1 325 cases with reliable data according with the selected criteria were investigated. 106 normotensives (65 men, 41women, mean age 52 years), 498 untreated simple hyper-tensives (288 men, 210 women, mean age 54 years) and 722 recently untreated hypertensives with TOD (490 men,232 women, mean age 58 years) including 53% cardiac damage, 16% cerebral damage, 9% renal damage and 22 % more than one organ damage were studied.

  15. The business of self-monitoring of blood glucose: a market profile. (United States)

    Hughes, Mark D


    The market for self-monitoring of blood glucose (SMBG) approached $8.8 billion worldwide in 2008. Yet despite dramatic double-digit growth in sales of SMBG products since 1980, the business is now facing declining prices and slower dollar growth. Given that SMBG meters and test strips are viewed by consumers and insurers as essentially generic products, it will be extremely challenging for new market entrants to displace well-entrenched existing competitors without a truly innovative technology. Also, in the face of declining glucose test strip prices, market expansion can only occur through identification of more of the undiagnosed diabetes population and convincing existing diabetes patients to adopt glucose testing or to test more frequently. Ultimately, a combination of technology innovations, patient education, and economic incentives may be needed to significantly expand the SMBG market and build sustainable long-term dollar growth for SMBG vendors.

  16. Effect of heparin in combined with magnesium sulfate on the blood gas and blood viscosity in patients with pulmonary heart failure

    Institute of Scientific and Technical Information of China (English)

    Rui Deng; Hong-Wei Liang; Jun-Hong Liao; Jun-Hua Chen; Hai-Yan Liu


    Objective:To observe the effect of heparin in combined with magnesium sulfate on the blood gas indicators and blood viscosity in patients with pulmonary heart disease merged with respiratory failure.Methods: A total of 80 patients with pulmonary heart disease merged with respiratory failure who were admitted in our hospital were included in the study and randomized into the observation group (n=40) and the control group (n=40). The patients in the control group were given routine symptomatic treatments of pulmonary heart disease. On the above basis, the patients in the observation group were given intravenous drip of heparin and magnesium sulfate. The patients in the two groups were treated for 2 weeks. The blood gas indicators, blood viscosity indicators, PAPs, SBP, and DBP in the two groups were compared. The clinical efficacy in the two groups was evaluated.Results:After 2-week treatment, PaO2 and PaCO2 in the two groups were improved, pH value was not significantly changed, PaO2 in the observation group was significantly higher than that in the control group, while PaCO2 was significantly lower than that in the control group. The hemorheology indicators after treatment in the two groups were significantly reduced when compared with before treatment, among which the comparison of WBV, PV, Hct, and EAI between the two groups was statistically significant, and PAPs after treatment in the observation group was significantly reduced when compared with the control group. SBP and DBP after treatment in the two groups were not significantly changed.Conclusions: Heparin in combined with magnesium sulfate in the treatment of pulmonary heart disease merged with respiratory failure can improve the blood gas indicators and blood viscosity indicators, and reduce SBP of pulmonary artery, with a higher efficacy; therefore, it deserves to be widely recommended in the clinic.

  17. Validation of pulse oximetry for monitoring of hypoxaemic episodes in the late postoperative period

    DEFF Research Database (Denmark)

    Stausholm, K; Rosenberg-Adamsen, S; Edvardsen, L;


    We monitored 12 patients undergoing major abdominal surgery using a pulse oximeter (Nellcor N-200) and a transcutaneous oxygen tension monitor (TINA, Radiometer A/S) on the second or third night after operation. Of the shortest hypoxaemic episodes measured with the pulse oximeter (... duration), 78% also occurred in the transcutaneous oxygen tension measurement. Episodes of longer duration (> or = 1 min duration on the pulse oximeter) were, in 95% of cases, reflected in the transcutaneous oxygen tension measurement also. Thus postoperative episodic desaturations lasting > or = 1 min...

  18. 急诊静脉血气分析的临床价值%Clinical value of venous blood gas analysis in emergency medical care

    Institute of Scientific and Technical Information of China (English)

    徐安忆; 单仁飞; 秦杰; 沈建飞


    Objective To analyze the correlation between arterial and peripheral venous blood gas analysis variables. Methods The datas including PubMed,Medline,Embase were systematically searched for the variables in adult emergency peripheral venous and arterial blood gas analysis,including pH,PCO2,HCO3- and BE from January 1966 to March,2015. The quality of studies was critically evaluated and the data were extracted by two reviewers independently. Meta-analysis was conducted by using the RevMan 5.2. Results Totally 17 studies were finally identified. The pH value of arterial blood gas analysis in patients with non shock is similar to venous blood gas analysis (WMD=0.00,95%CI:-0.01~0.02,P>0.05). The PCO2 value of arterial blood gas analysis and venous blood gas analysis is obviously different (WMD=-3.87,95%CI:-4.35~-3.38,P0.05)as well as BE value(MD=0.09,95%CI:-0.97~0.55). Conclusion It had sufficient evidence to support that the pH and HCO3- of the arterial blood gas analysis in patients with non shock patients is similar with peripheral venous blood gas analysis. But there is no enough data to show the correlation between arterial and venous blood gas analysis in patients with shock or disturbance of acid-base balance. The difference between peripheral venous blood gas analysis and arterial blood gas analysis PCO2 value is obvious,it is difficult to predict the PCO2 value of arterial blood gas analysis by using PCO2 value of peripheral venous gas analysis in clinical,but the partial pressure of CO2 could apply in the arterial hypercarbia selection or partial carbon dioxide pressure monitoring.%目的:分析动脉和外周静脉血气分析变量之间的相关性。方法计算机检索PubMed、Medline、Embase数据库,收集1966年1月至2015年3月成人急诊比较外周动脉和静脉血气分析值,包括氢离子浓度指数(pH)值、二氧化碳分压(PCO2)、碳酸氢盐(HCO3-)和剩余碱(BE)的研究。由2名研究者独立对文献进

  19. Evaluation of OneTouch Verio, a new blood glucose self-monitoring system for patients with diabetes

    DEFF Research Database (Denmark)

    Littman, Karin; Petersen, Eva R.B.; Pussinen, Christel


    Introduction. Self-monitoring of blood glucose (SMBG) is important in diabetes management. Reliable and user-friendly instruments are essential. OneTouch Verio® is a new blood glucose concentration-measuring system designed to be used by patients with diabetes and healthcare professionals...... (ADA) quality goals. Blood samples were collected and measured on the OneTouch Verio® by laboratory personnel and patients with diabetes (n = 91, randomized into groups receiving personal training or mail instructions for the OneTouch Verio® system). Results were compared to a validated routine method......, imprecision and bias were calculated. User-friendliness was evaluated with a questionnaire. Results. Quality specifications for blood glucose concentration monitoring systems according to ISO 15197 were fulfilled. The mean coefficients of variation (CV%) of repeatability was 3.4% when tested by laboratory...

  20. [Blood pressure monitoring - Status quo and future : A contribution to the personalized medicine]. (United States)

    Engelmann, L; Kunig, S; Kunig, H


    Sustainment of life demands that the heart create sufficient pressure to maintain enough flow to keep the body healthy and oxygenated. Blood pressures can be easily measured, while volume measurements required additional invasive procedures. In analogy to volumetrically determined ejection fraction, a pressure ejection fraction EF(P) may be calculated. When standardized to heart rate and body surface area, a new, effective performance metric may be defined. These metrics enable the long-term monitoring of the critically ill patient. When presented in a performance diagram, the metrics contain prognostic implications and enable a real-time evaluation of the efficacy of therapeutic measures. Until now, pressure-related prognostic statements were based on statistical averages, which by definition apply to groups. With this new analytical approach, we have the ability to provide patient-specific therapeutics in an area of medicine that requires individualized treatment. Here, we show preliminary results of applying a mathematical risk analysis to blood pressure metrics to assess therapeutic risk.

  1. Fully Autonomous Multiplet Event Detection: Application to Local-Distance Monitoring of Blood Falls Seismicity

    Energy Technology Data Exchange (ETDEWEB)

    Carmichael, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carr, Christina [Univ. of Alaska, Fairbanks, AK (United States); Pettit, Erin C. [Univ. of Alaska, Fairbanks, AK (United States)


    We apply a fully autonomous icequake detection methodology to a single day of high-sample rate (200 Hz) seismic network data recorded from the terminus of Taylor Glacier, ANT that temporally coincided with a brine release episode near Blood Falls (May 13, 2014). We demonstrate a statistically validated procedure to assemble waveforms triggered by icequakes into populations of clusters linked by intra-event waveform similarity. Our processing methodology implements a noise-adaptive power detector coupled with a complete-linkage clustering algorithm and noise-adaptive correlation detector. This detector-chain reveals a population of 20 multiplet sequences that includes ~150 icequakes and produces zero false alarms on the concurrent, diurnally variable noise. Our results are very promising for identifying changes in background seismicity associated with the presence or absence of brine release episodes. We thereby suggest that our methodology could be applied to longer time periods to establish a brine-release monitoring program for Blood Falls that is based on icequake detections.

  2. Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma (United States)

    Sun, Fang; Hung, Hsiang-Chieh; Sinclair, Andrew; Zhang, Peng; Bai, Tao; Galvan, Daniel David; Jain, Priyesh; Li, Bowen; Jiang, Shaoyi; Yu, Qiuming


    Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive analytical technique with molecular specificity, making it an ideal candidate for therapeutic drug monitoring (TDM). However, in critical diagnostic media including blood, nonspecific protein adsorption coupled with weak surface affinities and small Raman activities of many analytes hinder the TDM application of SERS. Here we report a hierarchical surface modification strategy, first by coating a gold surface with a self-assembled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zwitterionic polymer brush layer to effectively repel protein fouling. We demonstrate how this modification can enable TDM applications by quantitatively and dynamically measuring the concentrations of several analytes--including an anticancer drug (doxorubicin), several TDM-requiring antidepressant and anti-seizure drugs, fructose and blood pH--in undiluted plasma. This hierarchical surface chemistry is widely applicable to many analytes and provides a generalized platform for SERS-based biosensing in complex real-world media.

  3. A rapid and reversible skull optical clearing method for monitoring cortical blood flow (United States)

    Zhang, Chao; Zhao, Yanjie; Shi, Rui; Zhu, Dan


    In vivo cortex optical imaging is of great important for revealing both structural and functional architecture of brain with high temporal-spatial resolution. To reduce the limitation of turbid skull, researchers had to establish various skull windows or directly expose cortex through craniotomy. Here we developed a skull optical clearing method to make skull transparent. Laser speckle contrast imaging technique was used to monitor the cortical blood flow after topical treatment with the optical clearing agents. The results indicated that the image contrast increased gradually, and then maintained at a high level after 15 min for adult mice, which made the image quality and resolution of micro-vessels nearly approximate to those of exposed cortex. Both the cortical blood flow velocity almost kept constant after skull became transparent. Besides, the treatment of physiological saline on the skull could make skull return to the initial state again and the skull could become transparent again when SOCS retreated it. Thus, we could conclude that the skull optical clearing method was rapid, valid, reversible and safe, which provided us available approach for performing the cortical structural and functional imaging at high temporal-spatial resolution.

  4. [Intraoperative monitoring of cerebral blood-flow and condition of cerebral at open and endovascular interventions in carotid system]. (United States)

    Kuntsevich, G I; Tanashian, M M; Skrylev, S I; Krotenkova, M V; Shchipakin, V L; Koshcheev, A Iu; Lagoda, O V; Gemdzhian, E G; Medvedev, R B; Kulikova, S N


    The aim of our research is to study hemodynamic and embolic situation during the carotid endarterectomy (CEA), carotid angioplastic and stenting (CAS), and to reveal the prognostic significance of the data provided by intraoperative monitoring of the brain blood flow in exposing acute ischemic lesions in brain. Intraoperative monitoring of blood flow in artery ophthalmic vas carried out with 60% of patients, in the middle cerebral artery-with 40% during the main stages of CEA, and with 64 patients in the middle cerebral artery during CAS. The comparison of the data of intraoperative monitoring of blood flow in middle cerebral artery with the result of brain diffusion-weighted magnetic resonance imaging (DW-MRI) 24 hours after the operation shows, that solid microembolic signals and vasospasm are prognostic signals (sensibility and specifics make up 95%) in the development of acute ischemic cerebral lesions. The monitoring of blood flow in artery ophthalmic is of the greatest diagnostic value in estimation of the hemodynamic situation, but it is of the lowest practical value in detecting microembolic signals. According to the data of the intraoperative blood flow monitoring in middle cerebral artery in group CEA the development of acute ischemic cerebral lesions were predicted with 11,1% of patients and the cause of postoperative stroke, developed by 2,9% of the patients, was specified. According to the result of DW-MRI, acute ischemic cerebral lesions were diagnosed with 21% of patients, that is, 18% of ischemic cerebral lesions were asymptomatic. In group CAS ischemic cerebral lesions were prognosed with 30% of patients, actually they were later detected with 40,6% of cases by means of DW-MRI. According to the data of intraoperative of blood flow monitoring the cause of the development of postoperative stroke was specified in 6,2% of cause; in 34,4% of cause the acute ischemic cerebral lesions were asymptomatic.

  5. Monitoring induced seismicity from underground gas storage: first steps in Italy (United States)

    Mucciarelli, Marco; Priolo, Enrico


    The supply of natural gas and its storage are focal points of the Italian politics of energy production and will have increasing importance in the coming years. About a dozen reservoirs are currently in use and fifteen are in development or awaiting approval. Some of these are found in the vicinity of geological structures that are seismically active. The assessment of seismic hazard (both for natural background and induced seismicity) for a geological gas storage facility has a number of unconventional aspects that must be recognized and traced in a clear, ordered way and using guidelines and rules that leave less room as possible for interpretation by the individual applicant / verification body. Similarly, for control and monitoring there are not clearly defined procedures or standard instrumentation, let alone tools for analysing and processing data. Finally, governmental organizations in charge of permission grants and operative control tend to have appropriate scientific knowledge only in certain areas and not in others (e.g. the seismic one), and the establishment of an independent multidisciplinary inspection body appears desirable. The project StoHaz ( aims to initiate a series of actions to overcome these deficiencies and allow to define procedures and standards for the seismic hazard assessment and control of the activities of natural gas storage in underground reservoirs. OGS will take advantage of the experience gained with the design, installation and maintenance of the seismic network monitoring the Collalto reservoir, at the moment the only example in Italy of a public research institution monitoring independently the activities of a private gas storage company.

  6. Evaluation of a novel artificial pancreas: closed loop glycemic control system with continuous blood glucose monitoring. (United States)

    Tsukamoto, Yuuki; Kinoshita, Yoshihiko; Kitagawa, Hiroyuki; Munekage, Masaya; Munekage, Eri; Takezaki, Yuka; Yatabe, Tomoaki; Yamashita, Koichi; Yamazaki, Rie; Okabayashi, Takehiro; Tarumi, Masatoshi; Kobayashi, Masaki; Mishina, Suguru; Hanazaki, Kazuhiro


    A closed-loop glycemic control system using an artificial pancreas has been applied with many clinical benefits in Japan since 1987. To update this system incorporating user-friendly features, we developed a novel artificial pancreas (STG-55). The purpose of this study was to evaluate STG-55 for device usability, performance of blood glucose measurement, glycemic control characteristics in vivo in animal experiments, and evaluate its clinical feasibility. There are several features for usability improvement based on the design concepts, such as compactness, display monitor, batteries, guidance function, and reduction of the preparation time. All animal study data were compared with a clinically available artificial pancreas system in Japan (control device: STG-22). We examined correlations of both blood glucose levels between two groups (STG-55 vs. control) using Clarke's error grid analysis, and also compared mean glucose infusion rate (GIR) during glucose clamp. The results showed strong correlation in blood glucose concentrations (Pearson's product-moment correlation coefficient: 0.97; n = 1636). Clarke's error grid analysis showed that 98.4% of the data fell in Zones A and B, which represent clinically accurate or benign errors, respectively. The difference in mean GIRs was less than 0.2 mg/kg/min, which was considered not significant. Clinical feasibility study demonstrated sufficient glycemic control maintaining target glucose range between 80 and 110 (mg/dL), and between 140 and 160 without any hypoglycemia. In conclusion, STG-55 was a clinically acceptable artificial pancreas with improved interface and usability. A closed-loop glycemic control system with STG-55 would be a useful tool for surgical and critical patients in intensive care units, as well as diabetic patients.

  7. Performance of two updated blood glucose monitoring systems: an evaluation following ISO 15197:2013. (United States)

    Pleus, Stefan; Baumstark, Annette; Rittmeyer, Delia; Jendrike, Nina; Haug, Cornelia; Freckmann, Guido


    Objective For patients with diabetes, regular self-monitoring of blood glucose (SMBG) is essential to ensure adequate glycemic control. Therefore, accurate and reliable blood glucose measurements with SMBG systems are necessary. The international standard ISO 15197 describes requirements for SMBG systems, such as limits within which 95% of glucose results have to fall to reach acceptable system accuracy. The 2013 version of this standard sets higher demands, especially regarding system accuracy, than the currently still valid edition. ISO 15197 can be applied by manufacturers to receive a CE mark for their system. Research design and methods This study was an accuracy evaluation following ISO 15197:2013 section 6.3 of two recently updated SMBG systems (Contour * and Contour TS; Bayer Consumer Care AG, Basel, Switzerland) with an improved algorithm to investigate whether the systems fulfill the requirements of the new standard. For this purpose, capillary blood samples of approximately 100 participants were measured with three test strip lots of both systems and deviations from glucose values obtained with a hexokinase-based comparison method (Cobas Integra † 400 plus; Roche Instrument Center, Rotkreuz, Switzerland) were determined. Percentages of values within the acceptance criteria of ISO 15197:2013 were calculated. This study was registered at (NCT02358408). Main outcome Both updated systems fulfilled the system accuracy requirements of ISO 15197:2013 as 98.5% to 100% of the results were within the stipulated limits. Furthermore, all results were within the clinically non-critical zones A and B of the consensus error grid for type 1 diabetes. Conclusions The technical improvement of the systems ensured compliance with ISO 15197 in the hands of healthcare professionals even in its more stringent 2013 version. Alternative presentation of system accuracy results in radar plots provides additional information with certain advantages. In addition

  8. Results of a Long-Term Demonstration of an Optical Multi-Gas Monitor on ISS (United States)

    Mudgett, Paul; Pilgrim, Jeffrey S.


    Previously at SAMAP we reported on the development of tunable diode laser spectroscopy (TDLS) based instruments for measuring small gas molecules in real time. TDLS technology has matured rapidly over the last 5 years as a result of advances in low power diode lasers as well as better detection schemes. In collaboration with two small businesses Vista Photonics, Inc. and Nanoracks LLC, NASA developed a 4 gas TDLS based monitor for an experimental demonstration of the technology on the International Space Station (ISS). Vista invented and constructed the core TDLS sensor. Nanoracks designed and built the enclosure, and certified the integrated monitor as a payload. The device, which measures oxygen, carbon dioxide, ammonia and water vapor, is called the Multi-Gas Monitor (MGM). MGM measures the 4 gases every few seconds and records a 30 second moving average of the concentrations. The relatively small unit draws only 2.5W. MGM was calibrated at NASA-Johnson Space Center in July 2013 and launched to ISS on a Soyuz vehicle in November 2013. Installation and activation of MGM occurred in February 2014, and the unit has been operating nearly continuously ever since in the Japanese Experiment Module. Data is downlinked from ISS about once per week. Oxygen and carbon dioxide data is compared with that from the central Major Constituents Analyzer. Water vapor data is compared with dew point measurements made by sensors in the Columbus module. The ammonia channel was tested by the crew using a commercial ammonia inhalant. MGM is remarkably stable to date. Results of 18 months of operation are presented and future applications including combustion product monitoring are discussed.

  9. 21 CFR 882.5890 - Transcutaneous electrical nerve stimulator for pain relief. (United States)


    ... pain relief. 882.5890 Section 882.5890 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Devices § 882.5890 Transcutaneous electrical nerve stimulator for pain relief. (a) Identification. A transcutaneous electrical nerve stimulator for pain relief is a device used to apply an electrical current...

  10. Role of National Accreditation Board of Hospitals and Healthcare Providers (NABH core indicators monitoring in quality and safety of blood transfusion

    Directory of Open Access Journals (Sweden)

    Anshu Gupta


    Full Text Available Context: Certain quality indicators are mandatory in the maintenance and improvement of quality in blood transfusion. Monitoring of such indicators should be done regularly and deficiencies are to be corrected for effective blood transfusion services. Aims: To study the usefulness of monitoring of the National Accreditation Board for Hospitals and Healthcare Providers (NABH core indicators in blood transfusion and in the maintenance of hemovigilance. Settings and Design: Hemovigilance is a "quality process" to improve quality and increase the safety of blood transfusion. It covers and surveys all activities of the blood transfusion chain from donors to recipients. Core indicators′ monitoring is a part of the hemovigilance process. Materials and Methods: A 2-year retrospective study was conducted in a blood storage unit of a NABH accredited tertiary care hospital of a metropolitan city. Four NABH core indicators in blood transfusion were observed and monitored by the clinical and blood storage unit staff of different levels. Results: It was observed that there was an improvement in quality by core indicators monitoring with decreased wastage of blood and blood components, decreased average turnaround time for issue of blood and blood components, and lesser number of transfusion reactions. Conclusion: This study demonstrated that monitoring of NABH core indicators results in the enhancement of quality and safety in blood transfusion services, reducing the incidence of transfusion reactions.

  11. Association between self-monitoring of blood glucose and diet among minority patients with diabetes* (United States)

    McANDREW, Lisa M.; HOROWITZ, Carol R.; LANCASTER, Kristie J.; QUIGLEY, Karen S.; POGACH, Leonard M.; MORA, Pablo A.; LEVENTHAL, Howard


    Background Self-monitoring of blood glucose (SMBG) is used to regulate glucose control. It is unknown whether SMBG can motivate adherence to dietary recommendations. We predicted that participants who used more SMBG would also report lower fat and greater fruit and vegetable consumption. Methods The present study was a cross-sectional study of 401 primarily minority individuals living with diabetes in East Harlem, New York. Fat intake and fruit and vegetable consumption were measured with the Block Fruit/Vegetable/Fiber and Fat Screeners. Results Greater frequency of SMBG was associated with lower fat intake (rs = −0.15; P < 0.01), but not fruit and vegetable consumption. The effects of SMBG were not moderated by insulin use; thus, the relationship was significant for those individuals both on and not on insulin. A significant interaction was found between frequency of SMBG and changing one’s diet in response to SMBG on total fat intake. The data suggest that participants who use SMBG to guide their diet do not have to monitor multiple times a day to benefit. Conclusion The present study found that the frequency of SMBG was associated with lower fat intake. Patients are often taught to use SMBG to guide their self-management. This is one of the first studies to examine whether SMBG is associated with better dietary intake. PMID:21599868

  12. Continuous cuff-less blood pressure monitoring based on the pulse arrival time approach: the impact of posture. (United States)

    Muehlsteff, J; Aubert, X A; Morren, G


    There is an unmet need for cuff-less blood pressure (BP) monitoring especially, in personal healthcare applications. The pulse arrival time (PAT) approach might offer a suitable solution to enable comfortable BP monitoring even at beat-level. However, the methodology is based on hemodynamic surrogate measures, which are sensitive to patient activities such as posture changes, not necessarily related to blood pressure variations. In this paper, we analyze the impact of posture on the PAT measure and related hemodynamic parameters such as the pre-ejection period in well-defined procedures. Additionally, the PAT of a monitored subject is investigated in an unsupervised scenario illustrating the complexity of such a measurement. Our results show the failure of blood pressure inference based on simple calibration strategies using the PAT measure only. We discuss opportunities to compensate for the observed effects towards the realization of wearable cuff-less blood pressure monitoring. These findings emphasize the importance of accessing context information in personal healthcare applications, where vital sign monitoring is typically unsupervised.


    Directory of Open Access Journals (Sweden)

    Zuvdija Cecunjanin


    Full Text Available Objective: The purpose of our retrospective study was to investigate the necessity of some laboratory testing in patients with acute bronchiolitis before and after treatment. Methods: We have taken blood samples of all children puncturing the cubital vein, and analyzed it using the Colter appliances-automatic counter blood count, for analyzes of a number of erythrocytes, leukocytes, platelets, differential blood count, Hct, Hb. CRP concentration in serum of patients determined by laser nephelometry with CardioPhase® high sensitivity C-reactive protein (hsCRP. For assessment of acid-base status and arterial blood gas analysis were used ABL5 and ABL700 Radiometer Copenhagen. We monitored the following parameters: pH, pCO2, HCO3-, total CO2, base excess, pO2, SpO2. Results: There was a significant improvement of hypoxemia after management of acute bronchiolitis in the form of a significant increase in average values of pO2 and SpO2 after treatment of acute bronchiolitis. The average value of the number of leukocytes and value of CRP in children were significantly decreased before and after management of acute bronchiolitis. There was no significant difference in duration of hospitalization in term and preterm newborns. Conclusion: No routine diagnostic tests are used routinely. However, there is an improvement of hypoxemia after management of acute bronchiolitis in children.

  14. On0Line Fuel Failure Monitor for Fuel Testing and Monitoring of Gas Cooled Very High Temperature Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ayman I. Hawari; Mohamed A. Bourham


    IVery High Temperature Reactors (VHTR) utilize the TRISO microsphere as the fundamental fuel unit in the core. The TRISO microsphere (~ 1- mm diameter) is composed of a UO2 kernel surrounded by a porous pyrolytic graphite buffer, an inner pyrolytic graphite layer, a silicon carbide (SiC) coating, and an outer pyrolytic graphite layer. The U-235 enrichment of the fuel is expected to range from 4% – 10% (higher enrichments are also being considered). The layer/coating system that surrounds the UO2 kernel acts as the containment and main barrier against the environmental release of radioactivity. To understand better the behavior of this fuel under in-core conditions (e.g., high temperature, intense fast neutron flux, etc.), the US Department of Energy (DOE) is launching a fuel testing program that will take place at the Advanced Test Reactor (ATR) located at Idaho National Laboratory (INL). During this project North Carolina State University (NCSU) researchers will collaborate with INL staff for establishing an optimized system for fuel monitoring for the ATR tests. In addition, it is expected that the developed system and methods will be of general use for fuel failure monitoring in gas cooled VHTRs.

  15. Using the first drop of blood for monitoring blood glucose values in critically ill patients: An observational study (United States)

    Saini, Sunita; Kaur, Sukhpal; Das, Karobi; Saini, Vikas


    Context: Using the first drop or second drop of blood while measuring blood glucose (BG) values. Objective: The study was planned to compare the BG values from the first and second drops of blood. Research Settings: The study was conducted at the Main Intensive Care Unit, PGIMER, Chandigarh, India. Research Design: This study was a comparative study. Materials and Methods: Ninety patients aged 2–93 years were enrolled in this study. BG values from the first and second drops of blood were taken and compared. Statistical Analysis Used: Agreement between two drops was assessed using Bland–Altman analysis. A bias of <10 mg/dl was considered clinically acceptable. Linear regression of the mean difference (bias) with the BG readings was performed. Results: One thousand four hundred and seven pairs of BG readings were taken from the enrolled patients. BG values had a bias of 3.9 ± 14.9 mg/dl. Nearly 96.7% of BG readings were within the limits of agreement. The absolute difference between first and second drops of blood was calculated; nearly 75.4% of the readings had fallen between 0 and 10 mg/dl, i.e. clinically acceptable range. Conclusion: There is no compete concordance of values of blood glucose between the first and the second drops of blood; any of the drops can be used for measuring BG values as the difference is not statistically significant. However, if hands are visibly clean and to decrease the blood loss in the critically ill patients where the BG values are measured frequently, using the first drop of blood is advised. PMID:27994381

  16. [Hemodynamics, blood gas composition and viscosity in patients with chronic obstructive bronchitis complicated by chronic cor pulmonale]. (United States)

    Verbitskiĭ, O N; Buturov, I V; Purkh, T Iu; Mohamed Fadi Fanari; Paraska, V I


    Hemodynamics, external respiratory function (ERF), blood gas composition and viscosity were studied in 120 patients with chronic obstructive bronchitis at different developmental stage of cor pulmonale. In pulmonary hypertension, there were moderate ERF disorders that became more marked in the compensatory and particularly decompensatory cor pulmonale. As bronchial patency deteriorated, the index of right ventricular performance increased from 0.76+0.081 to 1.23+0.022 in the examinees. Examination of blood gas composition revealed insignificant hypoxemia in pulmonary hypertension and compensatory cor pulmonale, which progressed with decompensation of chronic cor pulmonale (CCP). As bronchial obstruction progressed, there were increases in systolic, diastolic, and mean pressure in the pulmonary artery. The viscosity of blood and plasma and the indices of red blood cell aggregation and deformability were in the normal range in pulmonary hypertension and compensatory CCP. In CCP decompensation, the viscosity of blood and plasma and the index of red blood cell aggregation were increased and the index of red blood cell deformability was decreased.

  17. Bird interactions with offshore oil and gas platforms: review of impacts and monitoring techniques. (United States)

    Ronconi, Robert A; Allard, Karel A; Taylor, Philip D


    Thousands of oil and gas platforms are currently operating in offshore waters globally, and this industry is expected to expand in coming decades. Although the potential environmental impacts of offshore oil and gas activities are widely recognized, there is limited understanding of their impacts on migratory and resident birds. A literature review identified 24 studies and reports of bird-platform interactions, most being qualitative and half having been peer-reviewed. The most frequently observed effect, for seabirds and landbirds, is attraction and sometimes collisions associated with lights and flares; episodic events have caused the deaths of hundreds or even thousands of birds. Though typically unpredictable, anecdotally, it is known that poor weather, such as fog, precipitation and low cloud cover, can exacerbate the effect of nocturnal attraction to lights, especially when coincidental with bird migrations. Other effects include provision of foraging and roosting opportunities, increased exposure to oil and hazardous environments, increased exposure to predators, or repulsion from feeding sites. Current approaches to monitoring birds at offshore platforms have focused on observer-based methods which can offer species-level bird identification, quantify seasonal patterns of relative abundance and distribution, and document avian mortality events and underlying factors. Observer-based monitoring is time-intensive, limited in spatial and temporal coverage, and suffers without clear protocols and when not conducted by trained, independent observers. These difficulties are exacerbated because deleterious bird-platform interaction is episodic and likely requires the coincidence of multiple factors (e.g., darkness, cloud, fog, rain conditions, occurrence of birds in vicinity). Collectively, these considerations suggest a need to implement supplemental systems for monitoring bird activities around offshore platforms. Instrument-based approaches, such as radar

  18. Evaluation of the Colin STBP-680 at rest and during exercise: an automated blood pressure monitor using R-wave gating.


    Bond, V.; Bassett, D R; Howley, E T; Lewis, J.; Walker, A J; Swan, P D; Tearney, R J; Adams, R.G.


    The application of automated blood pressure measurement during exercise has been limited by inaccuracies introduced by the effects of accompanying motion and noise. We evaluated a newly developed automated blood pressure monitor for measuring exercise blood pressure (Colin STBP-680; Colin, San Antonio, Texas, USA). The STBP-680 uses acoustic transduction with the assistance of the electrocardiogram R-wave to trigger the sampling period for blood pressure measurement. The automated monitor rea...

  19. On-line blood viscosity monitoring in vivo with a central venous catheter, using electrical impedance technique. (United States)

    Pop, Gheorghe A M; Bisschops, Laurens L A; Iliev, Blagoy; Struijk, Pieter C; van der Hoeven, Johannes G; Hoedemaekers, Cornelia W E


    Blood viscosity is an important determinant of microvascular hemodynamics and also reflects systemic inflammation. Viscosity of blood strongly depends on the shear rate and can be characterized by a two parameter power-law model. Other major determinants of blood viscosity are hematocrit, level of inflammatory proteins and temperature. In-vitro studies have shown that these major parameters are related to the electrical impedance of blood. A special central venous catheter was developed to measure electrical impedance of blood in-vivo in the right atrium. Considering that blood viscosity plays an important role in cerebral blood flow, we investigated the feasibility to monitor blood viscosity by electrical bioimpedance in 10 patients during the first 3 days after successful resuscitation from a cardiac arrest. The blood viscosity-shear rate relationship was obtained from arterial blood samples analyzed using a standard viscosity meter. Non-linear regression analysis resulted in the following equation to estimate in-vivo blood viscosity (Viscosity(imp)) from plasma resistance (R(p)), intracellular resistance (R(i)) and blood temperature (T) as obtained from right atrium impedance measurements: Viscosity(imp)=(-15.574+15.576R(p)T)SR ((-.138RpT-.290Ri)). This model explains 89.2% (R(2)=.892) of the blood viscosity-shear rate relationship. The explained variance was similar for the non-linear regression model estimating blood viscosity from its major determinants hematocrit and the level of fibrinogen and C-reactive protein (R(2)=.884). Bland-Altman analysis showed a bias between the in-vitro viscosity measurement and the in-vivo impedance model of .04 mPa s at a shear rate of 5.5s(-1) with limits of agreement between -1.69 mPa s and 1.78 mPa s. In conclusion, this study demonstrates the proof of principle to monitor blood viscosity continuously in the human right atrium by a dedicated central venous catheter equipped with an impedance measuring device. No safety

  20. Physics Simulation Software for Autonomous Propellant Loading and Gas House Autonomous System Monitoring (United States)

    Regalado Reyes, Bjorn Constant


    1. Kennedy Space Center (KSC) is developing a mobile launching system with autonomous propellant loading capabilities for liquid-fueled rockets. An autonomous system will be responsible for monitoring and controlling the storage, loading and transferring of cryogenic propellants. The Physics Simulation Software will reproduce the sensor data seen during the delivery of cryogenic fluids including valve positions, pressures, temperatures and flow rates. The simulator will provide insight into the functionality of the propellant systems and demonstrate the effects of potential faults. This will provide verification of the communications protocols and the autonomous system control. 2. The High Pressure Gas Facility (HPGF) stores and distributes hydrogen, nitrogen, helium and high pressure air. The hydrogen and nitrogen are stored in cryogenic liquid state. The cryogenic fluids pose several hazards to operators and the storage and transfer equipment. Constant monitoring of pressures, temperatures and flow rates are required in order to maintain the safety of personnel and equipment during the handling and storage of these commodities. The Gas House Autonomous System Monitoring software will be responsible for constantly observing and recording sensor data, identifying and predicting faults and relaying hazard and operational information to the operators.

  1. Use of dried blood samples for monitoring hepatitis B virus infection

    Directory of Open Access Journals (Sweden)

    Muñoz Onofre


    Full Text Available Abstract Background Hepatitis B virus (HBV infection is a problem in several regions of the world with limited resources. Blood samples dried on filter paper (DBS have been successfully used to diagnose and monitor several infectious diseases. In Mexico there is an urgent need for an affordable and easy sampling method for viral load (VL testing and monitoring of chronic HBV infection. The purpose of this work was to validate the utility of DBS samples for monitoring HBV infection in patients from Mexico City. Methods Matched samples of plasma and DBS on filter paper from 47 HBV infected patients from the Instituto Mexicano del Seguro Social (IMSS, were included. To evaluate the DNA stability and purity from DBS stored at different temperature conditions, samples from ten patients were stored at 4 degree, 25 degree, and 37 degree C for 7 days. After DBS elution and DNA extraction, the purity of these samples was determined measuring the O.D. rate 260/280. The DBS utility for molecular studies was assessed with PCR assays to amplify a 322 bp fragment from the "a" determinant region of the HBV "S" gene. The VL from all samples was determined to evaluate the correlation between plasma and DBS matched samples. Results The quality of the DNA from DBS specimen is not adversely affected by storage at 4 degree, 25 degree and 37 degree C for up 7 days. Statistical ANOVA analyses did not show any significant difference. The same amplification efficiency was observed between DNA templates from samples stored at different temperatures. The Pearson correlation between the VL from DBS and plasma matched samples was 0.93 (p = 0.01. The SD was 1.48 for DBS vs.1.32 for Plasma, and an average of log10 copies/mL of 5.32 vs. 5.53. ANOVA analysis did not show any statistically significant difference between the analyzed groups (p = 0.92. Conclusion The results provide strong evidence that the isolation and quantification of DNA-HBV from DBS is a viable alternative

  2. Wearable autonomous microsystem with electrochemical gas sensor array for real-time health and safety monitoring. (United States)

    Li, Haitao; Mu, Xiaoyi; Wang, Zhe; Liu, Xiaowen; Guo, Min; Jin, Rong; Zeng, Xiangqun; Mason, Andrew J


    Airborne pollution and explosive gases threaten human health and occupational safety, therefore generating high demand for a wearable autonomous multi-analyte gas sensor system for real-time environmental monitoring. This paper presents a system level solution through synergistic integration of sensors, electronics, and data analysis algorithms. Electrochemical sensors featuring ionic liquids were chosen to provide low-power room-temperature operation, rapid response, high sensitivity, good selectivity, and a long operating life with low maintenance. The system utilizes a multi-mode electrochemical instrumentation circuit that combines all signal condition functions within a single microelectronics chip to minimize system cost, size and power consumption. Embedded sensor array signal processing algorithms enable gas classification and concentration estimation within a real-world mixture of analytes. System design and integration methodologies are described, and preliminary results are shown for a first generation SO(2) sensor and a thumb-drive sized prototype system.

  3. In Vivo Monitoring of Hemodynamic Changes during Clogging and Unclogging of Blood Supply for the Application of Clinical Shock Detection (United States)

    Kanawade, Rajesh; Stelzle, Florian; Schmidt, Michael

    This paper presents a novel methodology in early detection of clinical shock by monitoring hemodynamic changes using diffuse reflectance measurement technique. Detailed prototype of the reflectance measurement system and data analysis technique of hemodynamic monitoring was carried out in our laboratory. The real time in-vivo measurements were done from the index finger. This study demonstrates preliminary results of real time monitoring of reduced/- oxyhemoglobin changes during clogging and unclogging of blood flow in the finger tip. The obtained results were verified with pulse-oximeter values, connected to the tip of the same index finger.

  4. Cerebral oximetry and cerebral blood flow monitoring in 2 pediatric survivors with out-of-hospital cardiac arrest. (United States)

    Abramo, Thomas; Aggarwal, Nitin; Kane, Ian; Crossman, Kristen; Meredith, Mark


    In pediatric out-of-hospital cardiac arrest (POHCA), cardiovascular monitoring tools have improved resuscitative endeavors and cardiovascular outcomes but with still poor neurologic outcomes. Regarding cardiac arrest in patients with congenital heart disease during surgery, the application of cerebral oximetry with blood volume index (BVI) during the resuscitation has shown significant results and prognostic significance. We present 2 POHCA patients who had cerebral oximetry with BVI monitoring during their arrest and postarrest phase in the emergency department and its potential prognostic aspect.Basic procedures include left and right cerebral oximetry with BVI monitoring at every 5-second interval during cardiac arrest, resuscitation, and postarrest in 2 POHCA patients in the pediatric emergency department.Regional cerebral tissue oxygen saturation (rSo2) with BVI readings in these 2 POHCA survivors demonstrated interesting cerebral physiology, blood flow, and potential prognostic outcome. In 1 patient, the reference range of cerebral rSo2 with positive blood flow during arrest and postarrest phases consistently occurred. This neurologic monitoring had its significance when the resuscitation effectiveness was used and end-tidal CO2 changes were lost. The other patient's cerebral rSo2 with simultaneous BVI readings and trending showed the effectiveness of the emergency medical services (EMS) resuscitation.Cerebral oximetry with cerebral blood flow index monitoring in these POHCA survivors demonstrates compelling periarrest and postarrest cerebral physiology information and prognostication. Cerebral oximetry with cerebral BVI monitoring during these arrest phases has potential as a neurologic monitor for the resuscitative intervention's effectiveness and its possible neurologic prognostic application in the pediatric OCHA patients.

  5. Remote sensing for gas plume monitoring using state-of-the-art infrared hyperspectral imaging (United States)

    Hinnrichs, Michele


    Under contract to the US Air Force and Navy, Pacific Advanced Technology has developed a very sensitive hyperspectral imaging infrared camera that can perform remote imaging spectro-radiometry. One of the most exciting applications for this technology is in the remote monitoring of gas plume emissions. Pacific Advanced Technology (PAT) currently has the technology available to detect and identify chemical species in gas plumes using a small light weight infrared camera the size of a camcorder. Using this technology as a remote sensor can give advanced warning of hazardous chemical vapors undetectable by the human eye as well as monitor the species concentrations in a gas plume from smoke stack and fugitive leaks. Some of the gas plumes that have been measured and species detected using an IMSS imaging spectrometer are refinery smoke stacks plumes with emission of CO2, CO, SO2, NOx. Low concentration vapor unseen by the human eye that has been imaged and measured is acetone vapor evaporating at room temperature. The PAT hyperspectral imaging sensor is called 'Image Multi-spectral Sensing or IMSS.' The IMSS instrument uses defractive optic technology and exploits the chromatic aberrations of such lenses. Using diffractive optics for both imaging and dispersion allows for a very low cost light weight robust imaging spectrometer. PAT has developed imaging spectrometers that span the spectral range from the visible, midwave infrared (3 to 5 microns) and longwave infrared (8 to 12 microns) with this technology. This paper will present the imaging spectral data that we have collected on various targets with our hyperspectral imaging instruments as will also describe the IMSS approach to imaging spectroscopy.

  6. Parameter monitoring system of the Dubna Gas-Filled Recoil Separator

    CERN Document Server

    Tsyganov, Y S; Sukhov, A M


    PC-based one-crate monitoring and control system of the Dubna Gas Filled Recoil Separator (DGFRS) is considered. It is developed for the long-term experiments at the U400 FLNR cyclotron and is aimed at the synthesis of super heavy nuclei in heavy ion induced complete fusion reactions. Parameters related to: a) beam and cyclotron; b) separator by itself, c) detection system, d) target and entrance window are measured and stored in the protocol file of the experiment. Special attention is paid to generating the alarm signals and implementing further the appropriate procedures

  7. Effect of deep anesthesia on blood gas and immune function in patients undergoing laparoscopic radical gastrectomy for gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Zhen Wang; Xiao-Fan Li; Hui Wang; Zhi-Jun Mao; Tong Xue; Rui Yang


    Objective:To investigate the effects of deep anesthesia on blood gas and immune function in patients undergoing laparoscopic radical gastrectomy for gastric cancer. Methods:A total of 84 gastric cancer patients in our hospital were randomly divided into observation group (42 cases) and control group (42 cases). Patients in observation group were treated by deep anesthesia, while the control group was treated with shallow anesthesia. The blood gas was observed and compared before and after CO2 pneumoperitoneum, and the immune function was observed and compared before anesthesia, after operation and 72 h post-operation. Results:The PaCO2 and pH level of patients in the two groups had no significant difference before pneumoperitoneum;Compared with before pneumoperitoneum, no obvious blood gas change was observed in the observation group, the difference had no statistically significant;Blood gas level of control group was significantly higher than that of before pneumoperitoneum , the difference was statistically significant, pH (7.26±0.07) was statistically decreased;After pneumoperitoneum, the level of PaCO2 and pH was significantly different in both groups , the difference was statistically significant. Indexes of the patients in the observation and control group of CD3+, CD4+, CD4+/CD8+, NK level had no significant difference before anesthesia, the difference was not statistically significant;The immunology index of CD3+, CD4+, CD4+/CD8+and NK cell levels of the postoperative patients in both groups were significantly lower than before anesthesia, and the differences were statistically significant, but each index in the observation group decreased significantly less than that of the control group, the difference was statistically significant;The immunological indexes can be restored to before anesthesia postoperative 72 h with two groups, and had no significant difference. Conclusion:The blood gas analysis index was stable and the immune function was suppressed in

  8. Clinical significance of blood gas and electrolyte analysis, CK, CK-MB and HBDH changes in neonatal asphyxia

    Institute of Scientific and Technical Information of China (English)

    Bao-Hua Xu; Xin Lin; Mi-Jia Huang


    Objective:To investigate the clinical significance of blood gas and electrolyte analysis, CK, CK-MB and HBDH changes in neonatal asphyxia.Methods:A total of 100 newborns with asphyxia who visited in our hospital were collected, and divided into severe group (n=20) and mild group (n=80) according to the asphyxia degree, and 50 healthy newborns regarded as control group. The 3 groups received blood gas analysis (pH, BE and PaCO2), electrolyte (K+, Na+ and Ca2+) and 3 kinds of enzymes (CK, CK-MB and HBDH) were tested and compared.Results: Compared with control group, pH and BE of blood gas indexes decreased significantly and PaCO2 increased significantly in severe group (P0.05). Compared with mild group, pH and BE of blood gas indexes decreased significantly and PaCO2 increased significantly in severe group (P0.05). Compared with mild group, the level of Ca2+ decreased significantly in severe group (P<0.05); Compared with control group, the levels of CK, CK-MB and HBDH increased significantly in severe and mild group (P<0.05). Compared with mild group, the levels of CK, CK-MB and HBDH increased significantly in severe group (P<0.05).Conclusions:The detection of blood gas and electrolyte analysis, CK, CK-MB and HBDH can provide an objective evidence for the diagnosis of neonatal asphyxia and estimation of severity degree which was helpful in clinical treatment.

  9. Calculation and verification of blood ethanol measurement uncertainty for headspace gas chromatography. (United States)

    Sklerov, Jason H; Couper, Fiona J


    An estimate was made of the measurement uncertainty for blood ethanol testing by headspace gas chromatography. While uncertainty often focuses on compliance to a single threshold level (0.08 g/100 mL), the existence of multiple thresholds, related to enhanced sentencing, subject age, or commercial vehicle licensure, necessitate the use of an estimate with validity across multiple specification levels. The uncertainty sources, in order of decreasing magnitude, were method reproducibility, linear calibration, recovery, calibrator preparation, reference material, and sample preparation. A large set of reproducibility data was evaluated (n = 15,433) in order to encompass measurement variability across multiple conditions, operators, instruments, concentrations and timeframes. The relative, combined standard uncertainty was calculated as ±2.7%, with an expanded uncertainty of ±8.2% (99.7% level of confidence, k = 3). Bias was separately evaluated through a recovery study using standard reference material from a national metrology institute. The uncertainty estimate was verified through the use of proficiency test (PT) results. Assigned values for PT results and their associated uncertainties were calculated as robust means (x*) and standard deviations (s*) of participant values. Performance scores demonstrated that the uncertainty estimate was appropriate across the full range of PT concentrations (0.010-0.370 g/100 mL). The use of PT data as an empirical estimate of uncertainty was not examined. Until providers of blood ethanol PT samples include details on how an assigned value is obtained along with its uncertainty and traceability, the use of PT data should be restricted to the role of verification of uncertainty estimates.


    Energy Technology Data Exchange (ETDEWEB)

    J. Robert Woolsey; Thomas M. McGee; Robin C. Buchannon


    The gas hydrates research Consortium (HRC), established and administered at the University if Mississippi's Center for Marine Research and Environmental Technology (CMRET) has been active on many fronts in FY 03. Extension of the original contract through March 2004, has allowed completion of many projects that were incomplete at the end of the original project period due, primarily, to severe weather and difficulties in rescheduling test cruises. The primary objective of the Consortium, to design and emplace a remote sea floor station for the monitoring of gas hydrates in the Gulf of Mexico by the year 2005 remains intact. However, the possibility of levering HRC research off of the Joint Industries Program (JIP) became a possibility that has demanded reevaluation of some of the fundamental assumptions of the station format. These provisions are discussed in Appendix A. Landmark achievements of FY03 include: (1) Continuation of Consortium development with new researchers and additional areas of research contribution being incorporated into the project. During this period, NOAA's National Undersea Research Program's (NURP) National Institute for Undersea Science and Technology (NIUST) became a Consortium funding partner, joining DOE and Minerals Management Service (MMS); (2) Very successful annual and semiannual meetings in Oxford Mississippi in February and September, 2003; (3) Collection of piston cores from MC798 in support of the effort to evaluate the site for possible monitoring station installation; (4) Completion of the site evaluation effort including reports of all localities in the northern Gulf of Mexico where hydrates have been documented or are strongly suspected to exist on the sea floor or in the shallow subsurface; (5) Collection and preliminary evaluation of vent gases and core samples of hydrate from sites in Green Canyon and Mississippi Canyon, northern Gulf of Mexico; (6) Monitoring of gas activity on the sea floor, acoustically

  11. Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples

    NARCIS (Netherlands)

    Hofman, Susan; Bolhuis, Mathieu S.; Koster, Remco A.; Akkerman, Onno W.; van Assen, Sander; Stove, Christophe; Alffenaar, Jan-Willem C.


    Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment. We subsequently examined potential use of dried blood spots as sample p

  12. Blood lactate concentrations are mildly affected by mobile gas exchange measurements. (United States)

    Scharhag-Rosenberger, F; Wochatz, M; Otto, C; Cassel, M; Mayer, F; Scharhag, J


    We sought to investigate the effects of wearing a mobile respiratory gas analysis system during a treadmill test on blood lactate (bLa) concentrations and commonly applied bLa thresholds. A total of 16 recreational athletes (31±3 years, VO2max: 58±6 ml · min(-1) · kg(-1)) performed one multistage treadmill test with and one without gas exchange measurements (GEM and noGEM). The whole bLa curve, the lactate threshold (LT), the individual anaerobic thresholds according to Stegmann (IATSt) and Dickhuth (IATDi), and a fixed bLa concentration of 4 mmol ∙ l(-1) (OBLA) were evaluated. The bLa curve was shifted slightly leftward in GEM compared to noGEM (Prate response was not different between conditions (P=0.89). There was no difference between GEM and noGEM for LT (2.61±0.34 vs. 2.64±0.39 m · s(-1), P=0.49) and IATSt (3.47±0.42 vs. 3.55±0.47 m · s(-1), P=0.12). However, IATDi (3.57±0.39 vs. 3.66±0.44 m · s(-1), Psystem. This also applies to bLa thresholds located at higher exercise intensities. While the magnitude of the effects is of little importance for recreational athletes, it might be relevant for elite athletes and scientific studies.

  13. Total on-line monitoring system of Tokyo gas transmission pipelines; Systeme global de controle et de surveillance des canalisations de transport du gaz developpe par Tokyo gas

    Energy Technology Data Exchange (ETDEWEB)

    Shibata, M. [Tokyo Gas Co., Ltd (Japan)


    As Tokyo Gas transmission pipeline is located in residential areas of Metropolitan Tokyo, more precise and advanced maintenance and inspection methods become necessary. A more efficient maintenance and inspection management system is being sought in line with the extension of gas transmission pipelines. Research and development is underway for various types of maintenance /monitoring systems that predict or detect pipeline damage or failure. Some systems have already been put to practical use. Tokyo Gas has developed a total online monitoring system featuring upgraded performance and centralized data processing. This system carries out 24-hour monitoring for damage and failure, and sends warnings to operators at the Pipeline Regional Network Office. This paper introduces the functions of the system, as well as the functions which are currently in the R and D stage. (author)

  14. Effective transcutaneous immunization by antigen-loaded flexible liposome in vivo

    Directory of Open Access Journals (Sweden)

    Li N


    Full Text Available Ni Li1, Li-Hua Peng1, Xi Chen1, Shinsaku Nakagawa2, Jian-Qing Gao11Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; 2Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, JapanBackground: Transcutaneous vaccines have received wide attention due to their easy-to-use, needle-free, noninvasive delivery. However, the novel barrier function of stratum corneum hinders the transport of antigen and adjuvant in transcutaneous immunization. Novel nanoscale delivery systems employing, for example, liposomes and nanoparticles, have been widely investigated to overcome the penetration barrier of stratum corneum for effective transcutaneous immunization.Objective: The objective of this study was to prepare two types of flexible liposomes and determine their efficacies for the transcutaneous delivery of antigen and the subsequent immune response induced in vivo.Methods: Ovalbumin (OVA liposome-based transcutaneous vaccines were prepared using reverse-phase evaporation and film-dispersion methods. Particle sizes and antigen encapsulating efficiency were then evaluated. After application to bare mouse skin, topical sites were examined for the presence of fluorescence-labeled liposome. The efficacy of the transcutaneously delivered OVA-loaded flexible liposome in activating the immune responses was investigated by detecting serum immunoglobulin G levels. The influence of an adjuvant, imiquimod, in the transcutaneous immunization was also tested.Results: Two flexible liposomes with well-encapsulated OVA were successfully prepared by film-dispersion or reverse-phase evaporation methods. The sizes of the prepared flexible liposomes ranged from 200 to 400 nm. In vivo, the fluorescence-labeled liposome was detected in hair-follicle ducts, indicating that the flexible liposome can penetrate the skin barrier through the hair

  15. US Navy Submarine Sea Trial of NASA developed Multi-Gas Monitor (United States)

    Mudgett, Paul D.; Manney, Joshua A.; Pilgrim, Jeffrey S.


    During a successful 2 year technology demonstration of the tunable diode laser spectroscopy (TDLS) based Multi-Gas Monitor (MGM) on the International Space Station (ISS), we began discussing with the US Navy the possibility of conducting a sea trial of an MGM on a submarine. The sea trial would also include a gas chromatography/differential mobility spectrometer based Air Quality Monitor (AQM), which is used operationally on ISS for select volatile organic compounds. AQM results will be the subject of a separate paper. The Navy’s interest in testing NASA equipment is in a planned update to the environmental monitoring equipment used aboard submarines. NASA’s goal is studying submarines as closed environment analogs to spacecraft. MGM’s core technology was developed by Vista Photonics Inc using Small Business Innovation Research (SBIR) grants and expanded for various applications using NASA program funding. The MGM measures oxygen, carbon dioxide, ammonia and water vapor in ambient air, displays concentrations with temperature and pressure, and stores 30 second moving averages. The sea trial involves colocating the instrument with the Central Air Monitor (CAM) and connecting it to rack power prior to departure, and letting it run during the entire sea trial of a few months duration. All data stored is inside MGM, with no connection to the vessel data bus. Crew intervention is limited to checking MGM periodically to see that it is working and power cycling if the display is OFF. After the trial is over, the unit with its data will be retrieved. Post sea trial calibration check and data analysis are planned and results will be compared with both CAM data and results from MGM’s ISS technology demonstration.

  16. European Society of Hypertension position paper on ambulatory blood pressure monitoring. (United States)

    O'Brien, Eoin; Parati, Gianfranco; Stergiou, George; Asmar, Roland; Beilin, Laurie; Bilo, Grzegorz; Clement, Denis; de la Sierra, Alejandro; de Leeuw, Peter; Dolan, Eamon; Fagard, Robert; Graves, John; Head, Geoffrey A; Imai, Yutaka; Kario, Kazuomi; Lurbe, Empar; Mallion, Jean-Michel; Mancia, Giuseppe; Mengden, Thomas; Myers, Martin; Ogedegbe, Gbenga; Ohkubo, Takayoshi; Omboni, Stefano; Palatini, Paolo; Redon, Josep; Ruilope, Luis M; Shennan, Andrew; Staessen, Jan A; vanMontfrans, Gert; Verdecchia, Paolo; Waeber, Bernard; Wang, Jiguang; Zanchetti, Alberto; Zhang, Yuqing


    Ambulatory blood pressure monitoring (ABPM) is being used increasingly in both clinical practice and hypertension research. Although there are many guidelines that emphasize the indications for ABPM, there is no comprehensive guideline dealing with all aspects of the technique. It was agreed at a consensus meeting on ABPM in Milan in 2011 that the 34 attendees should prepare a comprehensive position paper on the scientific evidence for ABPM.This position paper considers the historical background, the advantages and limitations of ABPM, the threshold levels for practice, and the cost-effectiveness of the technique. It examines the need for selecting an appropriate device, the accuracy of devices, the additional information and indices that ABPM devices may provide, and the software requirements.At a practical level, the paper details the requirements for using ABPM in clinical practice, editing considerations, the number of measurements required, and the circumstances, such as obesity and arrhythmias, when particular care needs to be taken when using ABPM.The clinical indications for ABPM, among which white-coat phenomena, masked hypertension, and nocturnal hypertension appear to be prominent, are outlined in detail along with special considerations that apply in certain clinical circumstances, such as childhood, the elderly and pregnancy, and in cardiovascular illness, examples being stroke and chronic renal disease, and the place of home measurement of blood pressure in relation to ABPM is appraised.The role of ABPM in research circumstances, such as pharmacological trials and in the prediction of outcome in epidemiological studies is examined and finally the implementation of ABPM in practice is considered in relation to the issue of reimbursement in different countries, the provision of the technique by primary care practices, hospital clinics and pharmacies, and the growing role of registries of ABPM in many countries.

  17. Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence. (United States)

    Lin, Hao-Cheng; Yang, Wen-Li; Zhang, Jun-Lan; Dai, Yu-Tian; Wang, Run


    Our previous study showed that vacuum erectile device (VED) therapy has improved erectile function in rats with bilateral cavernous nerve crush (BCNC) injuries. This study was designed to explore the mechanism of VED in penile rehabilitation by analyzing cavernous oxygen saturation (SO2) and to examine the effect of VED therapy on preventing penile shrinkage after BCNC. Thirty adult Sprague-Dawley rats were randomly assigned into three groups: group 1, sham surgery; group 2, BCNC; and group 3, BCNC+VED. Penile length and diameter were measured on a weekly basis. After 4 weeks of therapy, the penile blood was extracted by three methods for blood gas analysis (BGA): method 1, cavernous blood was aspirated at the flaccid state; method 2, cavernous blood was aspirated at the traction state; and method 3, cavernous blood was aspirated immediately after applying VED. SO2 values were tested by the blood gas analyzer. The results showed that VED therapy is effective in preventing penile shrinkage induced by BCNC (Penile shortening: BCNC group 1.9±1.1 mm; VED group 0.3±1.0 mm; P<0.01. Penile diameter reduction: BCNC group 0.28±0.14 mm; VED group 0.04±0.14 mm; P<0.01). The mean SO2±s.d. values were increased by VED application (88.25%±4.94%) compared to the flaccid (76.53%±4.16%) or traction groups (78.93%±2.56%) (P<0.05). The calculated blood constructs in the corpus cavernosum right after VED application were 62% arterial and 38% venous blood. These findings suggest that VED therapy can effectively preserve penile size in rats with BCNC injury. The beneficial effect of VED therapy is related to antihypoxia by increasing cavernous blood SO2.

  18. Monitoring and Protection of Oil and Gas Condition in Industrial Using Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Y. Chalapathi Rao


    Full Text Available Wireless Sensor Networks (WSNs are one of the fastest growing and emerging technologies in the field of Wireless networking today. WSNs have a vast amount of applications including environmental monitoring, military, ecology, agriculture, inventory control, robotics and health care. This paper focuses on monitoring and protection of oil and gas operations using WSNs that are optimized to decrease installation, and maintenance cost, energy requirements, increase reliability and improve communication efficiency. In addition, simulation experiments using the proposed model are presented. Such models could provide new tools for research in predictive maintenance and condition-based monitoring of factory machinery in general and for open architecture machining systems in particular. Wireless sensing no longer needs to be relegated to locations where access is difficult or where cabling is not practical. Wireless condition monitoring systems can be cost effectively implemented in extensive applications that were historically handled by running routes with data collectors. The result would be a lower cost program with more frequent data collection, increased safety, and lower spare parts inventories. Facilities would be able to run leaner because they will have more confidence in their ability to avoid downtime

  19. Dynamic Monitoring on the Bacterial Endotoxin Concentration in Whole Blood and Blood Component%全血及成分血内毒素动态监测

    Institute of Scientific and Technical Information of China (English)

    鲍自谦; 刘怡; 王飞; 陈云龙


    目的 通过监测全血及成分血的内毒素含量动态变化,探讨内毒素监控的意义,为评估血液安全提供依据,保证安全输血.方法 选择2009年3月至4月本血液中心献血者中,符合国家《献血者健康检查要求》的自愿献血者血液样品300份为研究对象.按血液成分分为3组:全血组(n=50)、悬浮RBC成分血组(n=150)及PLT成分血组(n=100).采用动态浊度法内毒素定量检测技术分别于各组血液保存前期、中期及后期检测各个血液样品内毒素含量,并采用方差分析比较各个检测时间点血样内毒素变化情况.结果 全血保存期前中后期中,内毒素含量在部分时段差异有统计学意义(W=0.860,P<0.05);而PLT悬液、悬浮RBC在3个时间段的内毒素含量差异无统计学意义(P>0.05).结论 对全血及成分血的内毒素含量监测,结果显示血液保存期的内毒素含量稳定与其细菌培养阴性相吻合,表明现行的采供血流程的质量控制是有效的,可有效保障血液的安全.%Objective To explore the importance of dynamic monitoring on the bacterial endotoxin and assess the blood safety to guarantee the safety of blood transfusion,through dynamically monitoring the bacterial endotoxin concentration in whole blood and blood component. Methods From March to April 2009,300 donors' samples,which had met the requirements of donors' health check,were included in this study.According to the blood component,all these samples were performed into three groups:whole blood group (n=50),red blood cells (RBC) suspension group (n=150),platelet (PLT) components group (n=100).Dynamic turbidity in blood which were respectively stored at early stage,metaphase and later stage,were used as the detection quantitative method of bacterial endotoxin.And the results were further analyzed by variance of repeated measurement data. Results There was no difference of the bacterial endotoxin concentration during the preservation in

  20. Evaluation of OneTouch Verio(®), a new blood glucose self-monitoring system for patients with diabetes

    DEFF Research Database (Denmark)

    Littmann, Karin; Petersen, Eva; Pussinen, Christel;


    Introduction. Self-monitoring of blood glucose (SMBG) is important in diabetes management. Reliable and user-friendly instruments are essential. OneTouch Verio(®) is a new blood glucose concentration-measuring system designed to be used by patients with diabetes and healthcare professionals...... routine method, imprecision and bias were calculated. User-friendliness was evaluated with a questionnaire. Results. Quality specifications for blood glucose concentration monitoring systems according to ISO 15197 were fulfilled. The mean coefficients of variation (CV%) of repeatability was 3.4% when....... The objective of the present study was to evaluate the analytical performance of the OneTouch Verio(®). Method. The OneTouch Verio(®) was evaluated by the Scandinavian evaluation of laboratory equipment for primary healthcare (SKUP) according to a protocol based on ISO 15197 and the American Diabetes...

  1. A System for Simple Real-Time Anastomotic Failure Detection and Wireless Blood Flow Monitoring in the Lower Limbs (United States)

    Rothfuss, Michael A.; Franconi, Nicholas G.; Unadkat, Jignesh V.; Gimbel, Michael L.; STAR, Alexander; Mickle, Marlin H.


    Current totally implantable wireless blood flow monitors are large and cannot operate alongside nearby monitors. To alleviate the problems with the current monitors, we developed a system to monitor blood flow wirelessly, with a simple and easily interpretable real-time output. To the best of our knowledge, the implanted electronics are the smallest in reported literature, which reduces bio-burden. Calibration was performed across realistic physiological flow ranges using a syringe pump. The device’s sensors connected directly to the bilateral femoral veins of swine. For each 1 min, blood flow was monitored, then, an occlusion was introduced, and then, the occlusion was removed to resume flow. Each vein of four pigs was monitored four times, totaling 32 data collections. The implant measured 1.70 cm3 without battery/encapsulation. Across its calibrated range, including equipment tolerances, the relative error is less than ±5% above 8 mL/min and between −0.8% and +1.2% at its largest calibrated flow rate, which to the best of our knowledge is the lowest reported in the literature across the measured calibration range. The average standard deviation of the flow waveform amplitude was three times greater than that of no-flow. Establishing the relative amplitude for the flow and no-flow waveforms was found necessary, particularly for noise modulated Doppler signals. Its size and accuracy, compared with other microcontroller-equipped totally implantable monitors, make it a good candidate for future tether-free free flap monitoring studies. PMID:27730016

  2. Using natural, stable calcium isotopes of human blood to detect and monitor changes in bone mineral balance. (United States)

    Channon, Melanie B; Gordon, Gwyneth W; Morgan, Jennifer L L; Skulan, Joseph L; Smith, Scott M; Anbar, Ariel D


    We are exploring variations in the Ca isotope composition of blood and urine as a new tool for early diagnosis and monitoring of changes in bone mineral balance for patients suffering from metabolic bone disease, cancers that originate in or metastasize to bone, and for astronauts who spend time in low gravity environments. Blood samples are often collected instead of, or in addition to, urine in clinical settings, so it is useful to know if variations in the Ca isotope composition of blood carry the same information as variations in urine. We found that the Ca isotope composition of blood shifts in the same direction and to the same magnitude (~2 parts per ten thousand--pptt) as that of urine in response to skeletal unloading during bed rest. However, the Ca isotope composition of blood is lighter than that of urine by 12 ± 2 pptt. This offset between blood and urine may result from Ca isotope fractionation occurring in the kidneys. This is the first study to confirm the suspected offset between the Ca isotope composition of blood and urine in humans, to directly quantify its magnitude, and to establish that either blood or urine can be used to detect and quantify bone loss.

  3. [Effects of procaterol on arterial blood gas and pulmonary function in asthmatic children]. (United States)

    Obata, T; Masaki, T; Iikura, Y


    We examined the changes in arterial blood gas, FEV1 and V50 after the inhalation of procaterol on 19 occasions in 16 asthmatic children. The initial value of PaO2 had statistically significant correlation with the initial values of %FEV1 and %V50. PaO2 fell down in 11 out of 19 (57.9%) and remarkably decreased more than 5 mmHg in 6 out of 19 (31.6%). The fall in PaO2 was most significant at 5 min after the inhalation in almost subjects. The changes in PaO2 after the inhalation had good correlation with the initial value of %FEV1 and %V50. The initial values were quite lower in the patients with decreased PaO2 more than 5 mmHg than those with increased PaO2. Severe patients showed statistically low values of the initial PaO2 and %V50 and showed a fall in PaO2 after inhalation compared with moderate patients. An increase in A-aDO2 elicited that deteriorations of V/Q ratio caused a decrease in PaO2 after inhalation. There were no significant changes in heart rates and no complaints of nausea, headache or tremor.

  4. Tissue gas and blood analyses of human subjects breathing 80% argon and 20% oxygen (United States)

    Horrigan, D. J.; Wells, C. H.; Guest, M. M.; Hart, G. B.; Goodpasture, J. E.


    Eight human volunteers, individually studied in a hyperbaric chamber, breathed: (1) air at 1 ATA; (2) 80% argon and 20% oxygen at 1 ATA for 30 min; (3) air at 1 ATA for 30 min; (4) 100% O2 at 1 ATA for 30 min; (5) air at 1 ATA for 30 min; (6) 100% O2 at 2 ATA for 60 min; and (7) 80% argon and 20% oxygen at 1 ATA for 30 min. Oxygen, carbon dioxide, nitrogen, and argon tensions were measured in muscle and subcutaneous tissue by mass spectroscopic analyses. Venous blood obtained at regular intervals was analyzed for coagulation and fibrinolytic factors. Inert gas narcosis was not observed. After breathing argon for 30 min, muscle argon tensions were almost three times the subcutaneous tensions. Argon wash-in mirrored nitrogen wash-out. Argon wash-in and wash-out had no effect on tissue PO2 or PCO2. Coagulation and fibrinolytic changes usually associated with vascular bubbles were absent.

  5. Monitoring and modeling wetland chloride concentrations in relationship to oil and gas development (United States)

    Post van der Burg, Max; Tangen, Brian A.


    Extraction of oil and gas via unconventional methods is becoming an important aspect of energy production worldwide. Studying the effects of this development in countries where these technologies are being widely used may provide other countries, where development may be proposed, with some insight in terms of concerns associated with development. A fairly recent expansion of unconventional oil and gas development in North America provides such an opportunity. Rapid increases in energy development in North America have caught the attention of managers and scientists as a potential stressor for wildlife and their habitats. Of particular concern in the Northern Great Plains of the U.S. is the potential for chloride-rich produced water associated with unconventional oil and gas development to alter the water chemistry of wetlands. We describe a landscape scale modeling approach designed to examine the relationship between potential chloride contamination in wetlands and patterns of oil and gas development. We used a spatial Bayesian hierarchical modeling approach to assess multiple models explaining chloride concentrations in wetlands. These models included effects related to oil and gas wells (e.g. age of wells, number of wells) and surficial geology (e.g. glacial till, outwash). We found that the model containing the number of wells and the surficial geology surrounding a wetland best explained variation in chloride concentrations. Our spatial predictions showed regions of localized high chloride concentrations. Given the spatiotemporal variability of regional wetland water chemistry, we do not regard our results as predictions of contamination, but rather as a way to identify locations that may require more intensive sampling or further investigation. We suggest that an approach like the one outlined here could easily be extended to more of an adaptive monitoring approach to answer questions about chloride contamination risk that are of interest to managers.

  6. Monitoring internal corrosion in natural gas pipelines; Monitoracao da corrosao interna em gasodutos

    Energy Technology Data Exchange (ETDEWEB)

    Nobrega, Ana C.V.; Silva, Djalma R.; Pimenta, Gutemberg S. [Universidade Federal do Rio Grande do Norte, Natal, RN (Brazil); Barbosa, Andrea F.F. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil). Centro de Pesquisas


    For susceptibilities to the corrosion of the pipelines and equipment made in carbon steel and used by the natural gas, it makes be necessary to identify the acting corrosive agents and monitoring them along time, controlling failures for internal corrosion. Also, of that process it origins the black powder (solid particles) that can not commit the structural integrity of the equipment, but it can also bring the company other implications very serious, like quality of the sold product, as well as stops due to blockages and wastes for erosion of the equipment. The monitoring methodology and control of the corrosion in field consisted of the use of corrosion test equipment, chemical characterization of samples of black powder and liquids and analysis of the operational data of processes and plants. Like this, it was identified for the gas pipeline in analysis the most responsible parameters for the corrosive action of the fluid, establishing a controlling methodology and operational actions to maintain the corrosion rates at safe levels and structural warranty of the same. (author)

  7. Spalax™ new generation: A sensitive and selective noble gas system for nuclear explosion monitoring. (United States)

    Le Petit, G; Cagniant, A; Gross, P; Douysset, G; Topin, S; Fontaine, J P; Taffary, T; Moulin, C


    In the context of the verification regime of the Comprehensive nuclear Test ban Treaty (CTBT), CEA is developing a new generation (NG) of SPALAX™ system for atmospheric radioxenon monitoring. These systems are able to extract more than 6cm(3) of pure xenon from air samples each 12h and to measure the four relevant xenon radioactive isotopes using a high resolution detection system operating in electron-photon coincidence mode. This paper presents the performances of the SPALAX™ NG prototype in operation at Bruyères-le-Châtel CEA centre, integrating the most recent CEA developments. It especially focuses on an innovative detection system made up of a gas cell equipped with two face-to-face silicon detectors associated to one or two germanium detectors. Minimum Detectable activity Concentrations (MDCs) of environmental samples were calculated to be approximately 0.1 mBq/m(3) for the isotopes (131m)Xe, (133m)Xe, (133)Xe and 0.4 mBq/m(3) for (135)Xe (single germanium configuration). The detection system might be used to simultaneously measure particulate and noble gas samples from the CTBT International Monitoring System (IMS). That possibility could lead to new capacities for particulate measurements by allowing electron-photon coincidence detection of certain fission products.

  8. Response of CO2 Concentration in Andisol to Rainfall Events by Using Buried Tubing Gas Monitoring System (United States)

    Endo, Toshifumi; Tokida, Takeshi; Imoto, Hiromi; Nishimura, Taku; Miyazaki, Tsuyoshi

    For the purpose of continuous soil CO2 gas monitoring, gas permeable resins were evaluated. Among polytetrafluoroethylen (PTFE), polyfluoroethylene propylene (PFEP) and silicone, the silicone rubber tube had highest permeability for oxygen gas. Buried Tubing Gas Monitoring System (BT-GMS) consisting of silicone rubber tube connected to a Non-diffuse infrared (NDIR) -CO2 gas and galvanic cell O2 gas sensors were constructed, and buried into an Andisol upland field at a depth of 20cm. Thermo-couples and EC-5 soil moisture sensors were inserted into 10 and 20cm deep layers. Soil CO2 gas concentration, temperature and moisture were continuously monitored for 5 months. Soil CO2 concentration was sensitive to rainfall events and soil moisture change. Responses were keen during summer until early autumn when soil temperature was higher than 20°C. Then, when soil temperature got lower the response tended to be dull. This suggested quick CO2 gas concentration change following a rainfall event was mostly due to enhancement in soil respiration with soil moisture rise.

  9. Simultaneous determination of polycyclic musks in blood and urine by solid supported liquid-liquid extraction and gas chromatography-tandem mass spectrometry. (United States)

    Liu, Hongtao; Huang, Liping; Chen, Yuxin; Guo, Liman; Li, Limin; Zhou, Haiyun; Luan, Tiangang


    A rapid, precise and accurate method for the simultaneous determination of 5 polycyclic musks (PCMs) in biological fluids was developed by solid supported liquid-liquid extraction (SLE) coupled with gas chromatography-tandem mass spectrometry (GC-MS/MS). All parameters influencing SLE-GC-MS performance, including electron energy of electron-impact ionization source, collision energy for tandem mass spectrometer when operated in selected-reaction monitoring (SRM) mode, type and volume of elution reagent, nitrogen evaporation time, pH and salinity of sample have been carefully optimized. Eight milliliter of n-hexane was finally chosen as elution reagent. Blood and urine sample could be loaded into SLE cartridge without adjusting pH and salinity. Deuterated tonalide (AHTN-d3) was chosen as internal standard. The correlation coefficient (r(2)) of the calibration curves of target compounds ranged from 0.9996 to 0.9998. The dynamic range spanned over two orders of magnitude. The limit of detection (LOD) of target compounds in blood and urine ranged from 0.008 to 0.105μgL(-1) and 0.005 to 0.075μgL(-1), respectively. The developed procedure was successfully applied to the analysis of PCMs in human blood and urine obtaining satisfying recoveries on low, medium and high levels. The method was compared with SLE-GC-MS and shown one to two orders of magnitude improvement in sensitivity.

  10. A highlight on lipid based nanocarriers for transcutaneous immunization. (United States)

    Nasr, Maha; Abdel-Hamid, Sameh; Alyoussef, Abdullah A


    Transcutaneous vaccination has become a widely used technique for providing immunity against several types of pathogens, taking advantage of the immune components found in the skin. The success in the field of vaccination has not only relied on the type of antigen and adjuvant delivered, but also on how they are delivered. In this regard, particulate carriers, especially nanoparticles have evoked considerable interest, owing to the desirable properties that they impart to the substance being delivered. The presentation of antigens by the nanoparticles mimics the presentation of the immunogen by the pathogen; hence, it creates a similar immune response. Furthermore, nanoparticles protect the antigen from degradation and allow its prolonged release, which maximizes its exposure to the immune cells. The most commonly used materials for the formulation of nanoparticles are either polymer-based or lipid based. This review will focus on the lipid based nanocarriers, either vesicular such as liposomes, transfersomes, and ethosomes, or non-vesicular such as cubosomes, solid lipid nanoparticles, nano-structured lipid carriers, solid in oil nanodispersions, lipoplexes, and hybrid polymeric-lipidic systems. The applications of these carriers in the field of transcutaneous immunization will be discussed in this review as well.

  11. Gas Bubble Trauma Monitoring and Research of Juvenile Salmonids, 1994-1995 Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Hans, Karen M.


    This report describes laboratory and field monitoring studies of gas bubble trauma (GBT) in migrating juvenile salmonids in the Snake and Columbia rivers. The first chapter describes laboratory studies of the progression of GBT signs leading to mortality and the use of the signs for GBT assessment. The progression and severity of GBT signs in juvenile salmonids exposed to different levels of total dissolved gas (TDG) and temperatures was assessed and quantified. Next, the prevalence, severity, and individual variation of GBT signs was evaluated to attempt to relate them to mortality. Finally, methods for gill examination in fish exposed to high TDG were developed and evaluated. Primary findings were: (1) no single sign of GBT was clearly correlated with mortality, but many GBT signs progressively worsened; (2) both prevalence and severity of GBT signs in several tissues is necessary; (3) bubbles in the lateral line were the earliest sign of GBT, showed progressive worsening, and had low individual variation but may develop poorly during chronic exposures; (4) fin bubbles had high prevalence, progressively worsened, and may be a persistent sign of GBT; and (5) gill bubbles appear to be the proximate cause of death but may only be relevant at high TDG levels and are difficult to examine. Chapter Two describes monitoring results of juvenile salmonids for signs of GBT. Emigrating fish were collected and examined for bubbles in fins and lateral lines. Preliminary findings were: (1) few fish had signs of GBT, but prevalence and severity appeared to increase as fish migrated downstream; (2) there was no apparent correlation between GBT signs in the fins, lateral line, or gills; (3) prevalence and severity of GBT was suggestive of long-term, non-lethal exposure to relatively low level gas supersaturated water; and (4) it appeared that GBT was not a threat to migrating juvenile salmonids. 24 refs., 26 figs., 3 tabs.

  12. Determination of VX-G analogue in red blood cells via gas chromatography-tandem mass spectrometry following an accidental exposure to VX. (United States)

    McGuire, Jeffrey M; Taylor, James T; Byers, Christopher E; Jakubowski, Edward M; Thomson, Sandra M


    A sensitive method for determining exposure to the chemical warfare agent VX is described in which the biomarker ethyl methylphosphonofluoridate (VX-G) is measured in red blood cells (RBCs) following treatment with fluoride ion using isotope-dilution gas chromatography-tandem mass spectrometry. The analyte was isolated via solid-phase extraction and detected using ammonia chemical ionization in the multiple reaction monitoring mode. A good linear relationship was obtained in the quantitative concentration range of 4 ng/mL to 1000 ng/mL with an absolute detection limit of VX vapor. Detection and quantitation of VX-G were possible in samples taken as late as 27 days following exposure.

  13. Commissioning of the KATRIN Raman system for monitoring of the WGTS gas composition

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Sebastian; Bornschein, Beate; James, Timothy M.; Off, Andreas; Rupp, Simone; Seitz-Moskaliuk, Hendrik; Sturm, Michael; Wecker, Matthias [Karlsruhe Institute of Technology (Germany); Schloesser, Magnus [Universidad Complutense de Madrid (Spain); Karlsruhe Institute of Technology (Germany); Telle, Helmut H. [Universidad Complutense de Madrid (Spain)


    The Karlsruhe Tritium Neutrino (KATRIN) Experiment aims at determining the neutrino mass by the investigation of the endpoint energy-region of the tritium β-spectrum. Tritium in its molecular form ({sup 3}H{sub 2}) is injected into the Windowless Gaseous Tritium Source (WGTS) of KATRIN, and thus molecular effects, e.g. ro-vibrational excitations levels, have to be considered in the neutrino mass analysis in order to reach the design sensitivity of 200 meV/c{sup 2} (90% C.L.). As the source gas also contains impurities of the other hydrogen isotopes protium and deuterium - giving rise to different molecular excitation levels - continuous and precise monitoring of the source gas composition is required. Raman spectroscopy is the method of choice for this task as it is an inline and non-contact analysis method. In this talk, results from the recently performed commissioning phase of the KATRIN Raman system are presented: over the course of more than 50 days, consecutive Raman spectra (recorded with acquisition times of 60 s) of circulating tritium gas were acquired and analysed in real-time. In addition, valuable information on the system performance during long-term operation was gained.

  14. Long-term blood pressure changes induced by the 2009 L'Aquila earthquake: assessment by 24 h ambulatory monitoring. (United States)

    Giorgini, Paolo; Striuli, Rinaldo; Petrarca, Marco; Petrazzi, Luisa; Pasqualetti, Paolo; Properzi, Giuliana; Desideri, Giovambattista; Omboni, Stefano; Parati, Gianfranco; Ferri, Claudio


    An increased rate of cardiovascular and cerebrovascular events has been described during and immediately after earthquakes. In this regard, few data are available on long-term blood pressure control in hypertensive outpatients after an earthquake. We evaluated the long-term effects of the April 2009 L'Aquila earthquake on blood pressure levels, as detected by 24 h ambulatory blood pressure monitoring. Before/after (mean±s.d. 6.9±4.5/14.2±5.1 months, respectively) the earthquake, the available 24 h ambulatory blood pressure monitoring data for the same patients were extracted from our database. Quake-related daily life discomforts were evaluated through interviews. We enrolled 47 patients (25 female, age 52±14 years), divided into three groups according to antihypertensive therapy changes after versus before the earthquake: unchanged therapy (n=24), increased therapy (n=17) and reduced therapy (n=6). Compared with before the quake, in the unchanged therapy group marked increases in 24 h (P=0.004), daytime (P=0.01) and nighttime (P=0.02) systolic blood pressure were observed after the quake. Corresponding changes in 24 h (P=0.005), daytime (P=0.01) and nighttime (P=0.009) diastolic blood pressure were observed. Daily life discomforts were reported more frequently in the unchanged therapy and increased therapy groups than the reduced therapy group (P=0.025 and P=0.018, respectively). In conclusion, this study shows that patients with unchanged therapy display marked blood pressure increments up to more than 1 year after an earthquake, as well as long-term quake-related discomfort. Our data suggest that particular attention to blood pressure levels and adequate therapy modifications should be considered after an earthquake, not only early after the event but also months later.

  15. Haematological, blood gas and acid-base effects of central histamine-induced reversal of critical haemorrhagic hypotension in rats. (United States)

    Jochem, J


    In a rat model of volume-controlled irreversible haemorrhagic shock, which results in a severe metabolic acidosis and the death of all control animals within 30 min., intracerebroventricular injection of histamine (100 nmol) produces a prompt and long-lasting increase in mean arterial pressure and heart rate, with a 100% survival of 2 h after treatment. Histamine action is accompanied by a decrease in haematocrit value, haemoglobin concentration, erythrocyte and platelet count, and an increase in residual blood volume at the end of the experiment (2 h). Cardiovascular effects are also associated with a long-lasting rise in respiratory rate and biphasic blood acid-base changes - initial increase of metabolic acidosis with the decrease in arterial and venous pH, bicarbonate concentration and base excess, followed by almost a complete recovery of blood gas and acid-base parameters to the pre-bleeding values, with normalisation of arterial and venous pH, Pco2 bicarbonate concentration and base excess at the end of experiment. It can be concluded that in the late phase of central histamine-induced reversal of haemorrhagic hypotension there is almost a complete restoration of blood gas and acid-base status due to circulatory and respiratory compensations, while accompanying haematological changes are the result of the haemodilution and the increase in residual blood volume.

  16. Developing monitoring plans to detect spills related to natural gas production. (United States)

    Harris, Aubrey E; Hopkinson, Leslie; Soeder, Daniel J


    Surface water is at risk from Marcellus Shale operations because of chemical storage on drill pads during hydraulic fracturing operations, and the return of water high in total dissolved solids (up to 345 g/L) from shale gas production. This research evaluated how two commercial, off-the-shelf water quality sensors responded to simulated surface water pollution events associated with Marcellus Shale development. First, peak concentrations of contaminants from typical spill events in monitored watersheds were estimated using regression techniques. Laboratory measurements were then conducted to determine how standard in-stream instrumentation that monitor conductivity, pH, temperature, and dissolved oxygen responded to three potential spill materials: ethylene glycol (corrosion inhibitor), drilling mud, and produced water. Solutions ranging from 0 to 50 ppm of each spill material were assessed. Over this range, the specific conductivity increased on average by 19.9, 27.9, and 70 μS/cm for drilling mud, ethylene glycol, and produced water, respectively. On average, minor changes in pH (0.5-0.8) and dissolved oxygen (0.13-0.23 ppm) were observed. While continuous monitoring may be part of the strategy for detecting spills to surface water, these minor impacts to water quality highlight the difficulty in detecting spill events. When practical, sensors should be placed at the mouths of small watersheds where drilling activities or spill risks are present, as contaminant travel distance strongly affects concentrations in surface water systems.

  17. A cell-based systems biology assessment of human blood to monitor immune responses after influenza vaccination. (United States)

    Hoek, Kristen L; Samir, Parimal; Howard, Leigh M; Niu, Xinnan; Prasad, Nripesh; Galassie, Allison; Liu, Qi; Allos, Tara M; Floyd, Kyle A; Guo, Yan; Shyr, Yu; Levy, Shawn E; Joyce, Sebastian; Edwards, Kathryn M; Link, Andrew J


    Systems biology is an approach to comprehensively study complex interactions within a biological system. Most published systems vaccinology studies have utilized whole blood or peripheral blood mononuclear cells (PBMC) to monitor the immune response after vaccination. Because human blood is comprised of multiple hematopoietic cell types, the potential for masking responses of under-represented cell populations is increased when analyzing whole blood or PBMC. To investigate the contribution of individual cell types to the immune response after vaccination, we established a rapid and efficient method to purify human T and B cells, natural killer (NK) cells, myeloid dendritic cells (mDC), monocytes, and neutrophils from fresh venous blood. Purified cells were fractionated and processed in a single day. RNA-Seq and quantitative shotgun proteomics were performed to determine expression profiles for each cell type prior to and after inactivated seasonal influenza vaccination. Our results show that transcriptomic and proteomic profiles generated from purified immune cells differ significantly from PBMC. Differential expression analysis for each immune cell type also shows unique transcriptomic and proteomic expression profiles as well as changing biological networks at early time points after vaccination. This cell type-specific information provides a more comprehensive approach to monitor vaccine responses.

  18. The determination of phenazone in blood plasma for obtained sistem suitable test of monitoring drug level


    Mochamad Lazuardi


    The determining of Phenazone to human blood plasma from healthy man after separated by solid phase extraction (SPE) and spectroscopic measurements has been investigated. The objective of that research was to obtain system suitable test for determine the Phenazone level in biological fluids (human blood plasma), for new performed dosage regimented in clinical dentistry. The method can be divided into the following four steps. 1. Centrifugation the blood sample, 2. Extraction from blood plasma ...

  19. Barriers to self-monitoring of blood glucose among adults with diabetes in an HMO: A cross sectional study

    Directory of Open Access Journals (Sweden)

    Barton Mary B


    Full Text Available Abstract Background Recent studies suggest that patients at greatest risk for diabetes complications are least likely to self-monitor blood glucose. However, these studies rely on self-reports of monitoring, an unreliable measure of actual behavior. The purpose of the current study was to examine the relationship between patient characteristics and self-monitoring in a large health maintenance organization (HMO using test strips as objective measures of self-monitoring practice. Methods This cross-sectional study included 4,565 continuously enrolled adult managed care patients in eastern Massachusetts with diabetes. Any self-monitoring was defined as filling at least one prescription for self-monitoring test strips during the study period (10/1/92–9/30/93. Regular SMBG among test strip users was defined as testing an average of once per day for those using insulin and every other day for those using oral sulfonylureas only. Measures of health status, demographic data, and neighborhood socioeconomic status were obtained from automated medical records and 1990 census tract data. Results In multivariate analyses, lower neighborhood socioeconomic status, older age, fewer HbA1c tests, and fewer physician visits were associated with lower rates of self-monitoring. Obesity and fewer comorbidities were also associated with lower rates of self-monitoring among insulin-managed patients, while black race and high glycemic level (HbA1c>10 were associated with less frequent monitoring. For patients taking oral sulfonylureas, higher dose of diabetes medications was associated with initiation of self-monitoring and HbA1c lab testing was associated with more frequent testing. Conclusions Managed care organizations may face the greatest challenges in changing the self-monitoring behavior of patients at greatest risk for poor health outcomes (i.e., the elderly, minorities, and people living in low socioeconomic status neighborhoods.

  20. The Blood Quality Monitoring Network System's Role in the Safety of Blood Transfusion%血液质量监测网络体系在输血安全中的作用

    Institute of Scientific and Technical Information of China (English)

    胡秀兰; 田志彬; 李忠杰; 玄红霞; 陈书芳


    目的探寻建立血站血液质量监测网络体系,确保血液质量与安全。方法对献血者献血前的血液标本进行初筛,对采血场所、关键原辅材料、关键设备进行质量控制,同时加强采后血液的质量监测以及各供血库的监测。结果比较质量监测网络体系建立前后血液质量情况,发现血液质量监测网络体系建立后血液质量有明显提高。结论建立完整有效、安全的血液质量监测网络体系,对血液的采集、检验、保存、运送和使用等多个环节进行血液质量监测,监控血液"从血管到血管"的全过程,确保献血者、用血者身体健康和生命安全。%Objective To explore the establishment of a blood bank blood quality monitoring network system to ensure the quality and safety of blood. Methods for screening blood donors before blood samples, blood col ection establishments, the key raw materials, key equipment for quality control quality, while strengthening the postharvest quality monitoring of blood as wel as monitoring for blood banks. Results the comparative quality monitoring network system to establish the quality of blood before and after situation, significantly improved blood quality monitoring network system to establish the quality of blood. Conclusions to establish a complete and ef ective, safe blood quality monitoring network system for blood col ection, testing, preservation, transportation and use of other aspects of the blood quality monitoring, monitoring of blood"from the blood vessels to the blood vessels,"the whole process to ensure donors with blood by the health and safety of life.

  1. Roles of preoperative arterial blood gas tests in the surgical treatment of scoliosis with moderate or severe pulmonary dysfunction

    Institute of Scientific and Technical Information of China (English)

    LIU Jia-ming; SHEN Jian-xiong; ZHANG Jian-guo; ZHAO Hong; LI Shu-gang; ZHAO Yu; QIU Giu-xing


    Background It has been stated that preoperative pulmonary function tests are essential to assess the surgical risk in patients with scoliosis.Arterial blood gas tests have also been used to evaluate pulmonary function before scoliotic surgery.However,few studies have been reported.The aim of this study was to investigate the roles of preoperative arterial blood gas tests in the surgical treatment of scoliosis with moderate or severe pulmonary dysfunction.Methods This study involved scoliotic patients with moderate or severe pulmonary dysfunction (forced vital capacity <60%) who underwent surgical treatment between January 2002 and April 2010.A total of 73 scoliotic patients (23 males and 50 females) with moderate or severe pulmonary dysfunction were included.The average age of the patients was 16.53 years (ranged 10-44).The demographic distribution,medical records,and radiographs of all patients were collected.All patients received arterial blood gas tests and pulmonary function tests before surgery.The arterial blood gas tests included five parameters:partial pressure of arterial oxygen,partial pressure of arterial carbon dioxide,alveolar-arterial oxygen tension gradient,pH,and standard bases excess.The pulmonary function tests included three parameters:forced expiratory volume in 1 second ratio,forced vital capacity ratio,and peak expiratory flow ratio.All five parameters of the arterial blood gas tests were compared between the two groups with or without postoperative pulmonary complications by variance analysis.Similarly,all three parameters of the pulmonary function tests were compared.Results The average coronal Cobb angle before surgery was 97.42° (range,50°-180°).A total of 15 (20.5%) patients had postoperative pulmonary complications,including hypoxemia in 5 cases (33.3%),increased requirement for postoperative ventilatory support in 4 (26.7%),pneumonia in 2 (13.3%),atelectasis in 2 (13.3%),pneumothorax in 1 (6.7%),and hydrothorax in 1

  2. Fission Product Monitoring of TRISO Coated Fuel For The Advanced Gas Reactor -1 Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Dawn M. Scates; John (Jack) K Hartwell; John B. Walter


    The US Department of Energy has embarked on a series of tests of TRISO-coated particle reactor fuel intended for use in the Very High Temperature Reactor (VHTR) as part of the Advanced Gas Reactor (AGR) program. The AGR-1 TRISO fuel experiment, currently underway, is the first in a series of eight fuel tests planned for irradiation in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The AGR-1 experiment reached a peak compact averaged burn up of 9% FIMA with no known TRISO fuel particle failures in March 2008. The burnup goal for the majority of the fuel compacts is to have a compact averaged burnup greater than 18% FIMA and a minimum compact averaged burnup of 14% FIMA. At the INL the TRISO fuel in the AGR-1 experiment is closely monitored while it is being irradiated in the ATR. The effluent monitoring system used for the AGR-1 fuel is the Fission Product Monitoring System (FPMS). The FPMS is a valuable tool that provides near real-time data indicative of the AGR-1 test fuel performance and incorporates both high-purity germanium (HPGe) gamma-ray spectrometers and sodium iodide [NaI(Tl)] scintillation detector-based gross radiation monitors. To quantify the fuel performance, release-to-birth ratios (R/B’s) of radioactive fission gases are computed. The gamma-ray spectra acquired by the AGR-1 FPMS are analyzed and used to determine the released activities of specific fission gases, while a dedicated detector provides near-real time count rate information. Isotopic build up and depletion calculations provide the associated isotopic birth rates. This paper highlights the features of the FPMS, encompassing the equipment, methods and measures that enable the calculation of the release-to-birth ratios. Some preliminary results from the AGR-1 experiment are also presented.

  3. Breath acetone monitoring by portable Si:WO{sub 3} gas sensors

    Energy Technology Data Exchange (ETDEWEB)

    Righettoni, Marco; Tricoli, Antonio; Gass, Samuel [Particle Technology Laboratory, Department of Mechanical and Process Engineering ETH Zurich, CH-8092 Zurich (Switzerland); Schmid, Alex; Amann, Anton [Univ.-Clinic for Anesthesia, Innsbruck Medical University, A-6020 Innsbruck (Austria); Breath Research Institute of the Austrian Academy of Sciences, A-6850 Dornbirn (Austria); Pratsinis, Sotiris E., E-mail: [Particle Technology Laboratory, Department of Mechanical and Process Engineering ETH Zurich, CH-8092 Zurich (Switzerland)


    Highlights: Black-Right-Pointing-Pointer Portable sensors were developed and tested for monitoring acetone in the human breath. Black-Right-Pointing-Pointer Acetone concentrations down to 20 ppb were measured with short response times (<30 s). Black-Right-Pointing-Pointer The present sensors were highly selective to acetone over ethanol and water. Black-Right-Pointing-Pointer Sensors were applied to human breath: good agreement with highly sensitive PTR-MS. Black-Right-Pointing-Pointer Tests with people at rest and during physical activity showed the sensor robustness. - Abstract: Breath analysis has the potential for early stage detection and monitoring of illnesses to drastically reduce the corresponding medical diagnostic costs and improve the quality of life of patients suffering from chronic illnesses. In particular, the detection of acetone in the human breath is promising for non-invasive diagnosis and painless monitoring of diabetes (no finger pricking). Here, a portable acetone sensor consisting of flame-deposited and in situ annealed, Si-doped epsilon-WO{sub 3} nanostructured films was developed. The chamber volume was miniaturized while reaction-limited and transport-limited gas flow rates were identified and sensing temperatures were optimized resulting in a low detection limit of acetone ({approx}20 ppb) with short response (10-15 s) and recovery times (35-70 s). Furthermore, the sensor signal (response) was robust against variations of the exhaled breath flow rate facilitating application of these sensors at realistic relative humidities (80-90%) as in the human breath. The acetone content in the breath of test persons was monitored continuously and compared to that of state-of-the-art proton transfer reaction mass spectrometry (PTR-MS). Such portable devices can accurately track breath acetone concentration to become an alternative to more elaborate breath analysis techniques.

  4. Loading of red blood cells with an analyte-sensitive dye for development of a long-term monitoring technique (United States)

    Ritter, Sarah C.; Meissner, Kenith E.


    Measurement of blood analytes, such as pH and glucose, provide crucial information about a patient's health. Some such analytes, such as glucose in the case of diabetes, require long-term or near-continuous monitoring for proper disease management. However, current monitoring techniques are far from ideal: multiple-per-day finger stick tests are inconvenient and painful for the patient; implantable sensors have short functional life spans (i.e., 3-7 days). Red blood cells serve as an attractive alternative for carriers of analyte sensors. Once reintroduced to the blood stream, these carriers may continue to live for the remainder of their life span (120 days for humans). They are also biodegradable and biocompatible, thereby eliminating the immune system response common for many implanted devices. The proposed carrier system takes advantage of the ability of the red blood cells to swell in response to a decrease in the osmolarity of the extracellular solution. Just before the membranes lyse, they develop small pores on the scale of tens of nanometers. Analyte-sensitive dyes in the extracellular solution may then diffuse into the perforated red blood cells and become entrapped upon restoration of physiological temperature and osmolarity. Because the membranes contain various analyte transporters, intracellular analyte levels rapidly equilibrate to those of the extracellular solution. A fluorescent dye has been loaded inside of red blood cells using a preswelling technique. Alterations in preparation parameters have been shown to affect characteristics of the resulting dye-loaded red blood cells (e.g., intensity of fluorescence).

  5. Analysis of feasibility of blood cell count in blood emergency arterial blood gas%急诊动脉血气分析用血进行血细胞计数的可行性探讨

    Institute of Scientific and Technical Information of China (English)

    黄万仁; 张桂芬; 张杰雄


    Objective To explore the feasibility of blood cell count in blood emergency arterial blood gas. Methods 153 patients of the emergency department of our hospital in 2008 March to 2013October were collected,arterial blood gas analysis andblood cell count were performed in all patients at the same time were all observed. Results Venous blood and the instant blood blood cell counts were compared,comparison of MCV,MCH,MCHC,MPV, PDW,P-LCR,BASO,the difference was statistically significant(P < 0.05);and the venous blood and the half hour blood blood cell counts were compared,comparison of HGB,HCT,RWD-SD,RWD-CV,PLT PDW,P-LCR,MPV,LYMPH,BASO,etc,the difference was statistically significant(P < 0.05). There are differences between the index of the linear analysis,venous blood and theinstant blood, half an hour of arterial blood indicators are positively correlated with significant(P < 0.05). Conclusion Analysis of blood transfusion in emergency inspection of arterial blood gas, in the instant conditions analysis of alternative venous blood forblood cell count.%目的:探讨急诊动脉血气分析用血进行血细胞计数的可行性。方法选取2008年3月~2013年10月我院急诊科进行治疗的患者153例,所有患者同时进行动脉血气分析和静脉血细胞计数分析。结果静脉血与即时动脉血血细胞计数均数比较,MCHC、MCV、MCH、MPV、P-LCR、BASO、PDW等指标比较,差异有统计学意义(P<0.05);而静脉血与半小时动脉血血细胞计数均数比较,HGB、HCT、RWD-SD、RWD-CV、PLT、MPV、PDW、P-LCR、LYMPH、BASO等比较,差异有统计学意义(P<0.05)。对各项有差异的指标做线性分析,即时动脉血、半小时动脉血各项指标与静脉血呈正相关关系(P<0.05)。结论动脉血气分析用血急诊检验中,在即时条件下可以替代静脉血行全血细胞计数分析。

  6. Effect of remifentanil combined with propofol anesthesia on stress response, blood gas index in patients with laparoscopic cholecystectomy

    Institute of Scientific and Technical Information of China (English)

    Yan-Dong Jiang; Su-Min Zhao


    Objective:To observe the effect of remifentanil combined with propofol anesthesia on stress response, blood gas index in patients with laparoscopic cholecystectomy. Methods:A total of 88 patients with laparoscopic cholecystectomy were randomly divided into the observation group (46 cases) and the control group (42 cases). After anesthesia induction,the observation group was given remifentanil combined with propofol intravenous anesthesia for continuous anesthesia, and control group was given isoflurane and propofol. Stress response (TNF-αα, CRP, BG, COGT), blood gas index (PaO2, PCO2, PH value) before surgery, before anesthesia maintained, and after surgery between two groups were compared. Results: Before anesthesia maintained and after surgery, PaO2 and PCO2 levels of the two groups increased with before surgery (P0.05). pH value of the two groups showed no change before and after surgery. Before anesthesia maintained and after surgery, TNF-αα, CRP, BG, COGT of the two groups increased with before surgery (P0.05) at before anesthesia maintained. While to the end of surgery, these index of the control group was significantly higher than that in the observation group (P<0.05). Conclusions:Remifentanil combined with propofol anesthesia can make blood gas index stable as well as isoflurane combined with propofol anesthesia, but inhibit stress response more significantly.

  7. Operational benefits obtained by implementing a remote monitoring and control system at CEGAS (Gas Company of Ceara, Brazil)

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Rui C.O. [Companhia de Gas do Ceara (CEGAS), Fortaleza, CE (Brazil); Zamponha, Rogerio S. [SOFTBRASIL, Sao Paulo, SP (Brazil)


    CEGAS (Gas Company of Ceara) recently implemented an automated remote monitoring and control system at the Natural Gas Stations located within the city of Fortaleza. The main purposes to implement the project were to install a better operational platform, allowing CEGAS to analyze its operational conditions and to measure customer's consumption in real time. The data communication infra-structure chosen was GPRS/GSM, due to it's low deployment cost and coverage availability. The first phase of the project comprised 50 vehicular natural gas stations. The project was successfully installed, and became the 1{sup st} project at this type to run efficiently over a GPRS infra-structure in Brazil for gas monitoring, with reliable control and data communication. This document intends to present the reasons that lead CEGAS to invest in such a system, the technology deployed and the benefits achieved. (author)

  8. Real-time electronic monitoring of a pitted and leaking gas gathering pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Asperger, R.G.; Hewitt, P.G.


    Hydrogen patch, flush electrical resistance, and flush linear polarization proves wre used with flush coupons to monitor corrosion rates in a pitted and leaking sour gas gathering line. Four inhibitors were evaluated in stopping the leaks. Inhibitor residuals and the amount and ratio of water and condensate in the lines were measured at five locations along the line. The best inhibitor reduced reduced the pit-leak frequency by over a factor of 10. Inhibitor usage rate was optimized using the hydrogen patch current as a measure of the instantaneous corrosion rate. Improper pigging was identified as a cause of corrosion transients. This problem is discussed in relation to the pigging of pipelines in stratified flow where moving fluids are the carriers for continuously injected corrosion inhibitors.

  9. Investigations into sensing characteristics of circular thin-plate electrostatic sensors for gas path monitoring

    Institute of Scientific and Technical Information of China (English)

    Zhongsheng Chen; Xin Tang; Zheng Hu; Yongmin Yang


    Circular thin-plate electrostatic sensors are promising in gas path monitoring due to their advantages of non-intrusiveness and easy installation. The spatial sensitivity and filtering effect are two important performance parameters. In this paper, an analytically mathematical model of induced charge on a circular thin-plate electrode is first derived. Then the spatial sensitivity and fil-tering effect of the circular electrostatic sensor are investigated by numerical calculations. Finally, experimental studies are performed to testify the theoretical results. Both theoretical and experimen-tal results demonstrate that circular thin-plate electrostatic sensors act as a low-pass filter in the spa-tial frequency domain, and both the spatial filtering effect and the temporal frequency response characteristics depend strongly on the spatial position and velocity of the charged particle. These conclusions can provide guidelines for the optimal design of circular thin-plate electrostatic sensors.

  10. Design and Evaluation of a Fully Implantable Control Unit for Blood Pumps

    Directory of Open Access Journals (Sweden)

    Kristin Unthan


    Full Text Available As the number of donor hearts is limited while more and more patients suffer from end stage biventricular heart failure, Total Artificial Hearts become a promising alternative to conventional treatment. While pneumatic devices sufficiently supply the patients with blood flow, the patient’s quality of life is limited by the percutaneous pressure lines and the size of the external control unit. This paper describes the development of the control unit of the ReinHeart, a fully implantable Total Artificial Heart. General requirements for any implantable control unit are defined from a technical and medical point of view: necessity of a Transcutaneous Energy Transmission, autonomous operation, safety, geometry, and efficiency. Based on the requirements, a prototype is designed; it incorporates a LiFePo4 battery pack with charger, a rectifier for transcutaneous energy transmission, the motor’s driver electronics, and a microcontroller which monitors and controls all functions. In validation tests, the control unit demonstrated a stable operation on TET and battery supply and a safe switching from one supply to the other. The overall mean efficiency is 14% on TET and 22% on battery supply. The control unit is suitable for chronic animal trials of the ReinHeart.

  11. Open and Closed Endotracheal Suctioning and Arterial Blood Gas Values: A Single-Blind Crossover Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Azam Faraji


    Full Text Available Aim. This study was aimed at comparing the effects of the open and closed suctioning techniques on the arterial blood gas values in patients undergoing open-heart surgery. Methods. In a clinical trial, we recruited 42 patients after open-heart surgery in an educational hospital. Each patient randomly underwent both open and closed suctioning. ABGs, PaO2, SaO2, PaCO2, were analyzed before and one, five, and fifteen minutes after each suctioning episode. Results. At first the pressure of oxygen in arterial blood increased; however, this increase in the open technique was greater than that of the closed system (P<0.001. The pressure of oxygen decreased five and fifteen minutes after both suctioning techniques (P<0.05. The trends of carbon dioxide variations after the open and closed techniques were upward and downward, respectively. Moreover, the decrease in the level of oxygen saturation five and fifteen minutes after the open suctioning was greater than that of the closed suctioning technique (P<0.05.  Conclusion. Arterial blood gas disturbances in the closed suctioning technique were less than those of the open technique. Therefore, to eliminate the unwanted effects of endotracheal suctioning on the arterial blood gases, the closed suctioning technique is recommended.

  12. 8th Annual Symposium on Self-Monitoring of Blood Glucose (SMBG): April 16-18, 2015, Republic of Malta. (United States)

    Parkin, Christopher G; Homberg, Anita; Hinzmann, Rolf


    International experts in the fields of diabetes, diabetes technology, endocrinology, mobile health, sport science, and regulatory issues gathered for the 8(th) Annual Symposium on Self-Monitoring of Blood Glucose (SMBG) with a focus on personalized diabetes management. The aim of this meeting was to facilitate new collaborations and research projects to improve the lives of people with diabetes. The 2015 meeting comprised a comprehensive scientific program, parallel interactive workshops, and two keynote lectures.

  13. Community pharmacy-based intervention to improve self-monitoring of blood glucose in type 2 diabetic patients

    Directory of Open Access Journals (Sweden)

    Müller U


    Full Text Available Self-monitoring of blood glucose (SMBG is clearly correlated with increased life expectancy and quality of life in type 2 diabetic patients. Objective: The objective of our study was to record and assess the errors patients make in preparing, performing, and processing self-monitoring of blood glucose (SMBG. Furthermore, the study aimed to determine to what extent a single standardized SMBG instruction session in a community pharmacy might reduce the number of patients making errors or the number of errors per patient. Methods: Between May and October 2005, SMBG of 462 randomly selected patients with type 2 diabetes was monitored in 32 pharmacies specialized in diabetes care. The patients performed blood glucose self-tests using their own blood glucose meters. Self-testing was monitored using a standardized documentation sheet on which any error made during the performance of the test was recorded. If necessary, patients were instructed in the accurate operation of their meter and the use of the necessary equipment. Additionally, patients obtained written instructions. Six weeks later, assessment of the quality of patient’s SMBG was repeated.Results: During the first observation, 383 patients (83% made at least one mistake performing SMBG. By the time of the second observation, this frequency had fallen to 189 (41% (p<0.001. The average number of mistakes fell from 3.1 to 0.8 per patient. Mistakes that may potentially have led to inaccurate readings were initially recorded for 283 (61% and at study end for 110 (24% patients (p<0.001. Conclusion: It is important to periodically instruct type 2 diabetic patients in the proper SMBG technique in order to ensure accurate measurements. In this study it was shown that community pharmacies specialized in diabetes care can provide this service effectively.

  14. Rationale and methodology of monitoring ambulatory blood pressure and arterial compliance in the Hypertension in the Very Elderly Trial



    OBJECTIVE: This article describes the rationale and methodology for the monitoring of ambulatory blood pressure and arterial compliance in hypertensive patients aged 80 years and above. This is a side project of the Hypertension in the Very Elderly Trial. METHODS: The hypertension in the Very Elderly Trial is a multicentre, double-blind, randomized, placebo-controlled trial aiming to investigate the effect of active treatment on cardiovascular and other outcomes in hypertensive patients aged ...

  15. Expected trace gas and aerosol retrieval accuracy of the Geostationary Environment Monitoring Spectrometer (United States)

    Jeong, U.; Kim, J.; Liu, X.; Lee, K. H.; Chance, K.; Song, C. H.


    The predicted accuracy of the trace gases and aerosol retrievals from the geostationary environment monitoring spectrometer (GEMS) was investigated. The GEMS is one of the first sensors to monitor NO2, SO2, HCHO, O3, and aerosols onboard geostationary earth orbit (GEO) over Asia. Since the GEMS is not launched yet, the simulated measurements and its precision were used in this study. The random and systematic component of the measurement error was estimated based on the instrument design. The atmospheric profiles were obtained from Model for Ozone And Related chemical Tracers (MOZART) simulations and surface reflectances were obtained from climatology of OMI Lambertian equivalent reflectance. The uncertainties of the GEMS trace gas and aerosol products were estimated based on the OE method using the atmospheric profile and surface reflectance. Most of the estimated uncertainties of NO2, HCHO, stratospheric and total O3 products satisfied the user's requirements with sufficient margin. However, about 26% of the estimated uncertainties of SO2 and about 30% of the estimated uncertainties of tropospheric O3 do not meet the required precision. Particularly the estimated uncertainty of SO2 is high in winter, when the emission is strong in East Asia. Further efforts are necessary in order to improve the retrieval accuracy of SO2 and tropospheric O3 in order to reach the scientific goal of GEMS. Random measurement error of GEMS was important for the NO2, SO2, and HCHO retrieval, while both the random and systematic measurement errors were important for the O3 retrievals. The degree of freedom for signal of tropospheric O3 was 0.8 ± 0.2 and that for stratospheric O3 was 2.9 ± 0.5. The estimated uncertainties of the aerosol retrieval from GEMS measurements were predicted to be lower than the required precision for the SZA range of the trace gas retrievals.

  16. Cost Evaluation of Dried Blood Spot Home Sampling as Compared to Conventional Sampling for Therapeutic Drug Monitoring in Children (United States)

    Martial, Lisa C.; Aarnoutse, Rob E.; Schreuder, Michiel F.; Henriet, Stefanie S.; Brüggemann, Roger J. M.; Joore, Manuela A.


    Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in children. This study aimed to compare all costs involved in conventional sampling versus DBS home sampling in two pediatric populations: renal transplant patients and hemato-oncology patients. Total costs were computed from a societal perspective by adding up healthcare cost, patient related costs and costs related to loss of productivity of the caregiver. Switching to DBS home sampling was associated with a cost reduction of 43% for hemato-oncology patients (€277 to €158) and 61% for nephrology patients (€259 to €102) from a societal perspective (total costs) per blood draw. From a healthcare perspective, costs reduced with 7% for hemato-oncology patients and with 21% for nephrology patients. Total savings depend on the number of hospital visits that can be avoided by using home sampling instead of conventional sampling. PMID:27941974

  17. Clinical study of transcutaneous vaccination using a hydrogel patch for tetanus and diphtheria. (United States)

    Hirobe, Sachiko; Matsuo, Kazuhiko; Quan, Ying-Shu; Kamiyama, Fumio; Morito, Hironori; Asada, Hideo; Takaya, Yusuke; Mukai, Yohei; Okada, Naoki; Nakagawa, Shinsaku


    Transcutaneous immunization (TCI) is a non-invasive and easy-to-use vaccination method. We demonstrated the efficacy and safety of a transcutaneous vaccine formulation using a hydrogel patch in animal experiments. In the present study, we performed a clinical study to apply our TCI formulation for vaccination against tetanus and diphtheria in human. The TCI device was a hydrogel patch (antigen-free) applied to the left brachial medial skin of 22 healthy volunteers for 48 h. Next, the hydrogel patch, containing 2mg tetanus toxoid (TT) and 2mg diphtheria toxoid (DT) as the TCI formulation, was applied to 27 healthy volunteers for 24h and some volunteers were vaccinated again by TCI formulation. For safety assessment, the patch application site was observed to assess local adverse events, and systemic adverse events were determined by a blood test. The antigen-free hydrogel patch and TCI formulation containing TT and DT did not induce local or systemic severe adverse events. For vaccine efficacy estimation, toxoid-specific serum antibody titers were determined by ELISA and the toxin-neutralizing activity of the induced antibody was evaluated in a passive-challenge experiment. The anti-TT IgG titer and the anti-DT IgG titer increased, and a significant effect was detected by paired t-test. The antibody titers were maintained at higher level than that before vaccination for at least 1 year. Moreover, toxoid-specific antibodies were produced by the second vaccination in some subjects. Antibodies induced by application of the TCI formulation neutralized the toxin and prevented toxic death in mice. In addition, changes in the skin condition due to application of the TCI formulation were observed under in vivo confocal Raman spectroscopy. The amount of water and patch components in the stratum corneum increased after application of the TCI formulation, suggesting that the change in the skin condition was related to antigen penetration. These data indicate that this easy

  18. Mobile monitoring of fugitive methane emissions from natural gas consumer industries (United States)

    Zhou, X.; Albertson, J. D.; Gaylord, A.; von Fischer, J.; Rudek, J.; Thoma, E. D.


    Natural gas is used as a feedstock for major industrial processes, such as ammonia and fertilizer production. However, fugitive methane emissions from many major end-use sectors of the natural gas supply chain have not been quantified yet. This presentation introduces new tools for estimating emission rates from mobile methane measurements, and examines results from recent field measurements conducted downwind of several industrial plants using a specialized vehicle equipped with fast response methane sensor. Using these data along with local meteorological data measured by a 3-D sonic anemometer, a Bayesian approach is applied to probabilistically infer methane emission rates based on a modified Gaussian dispersion model. Source rates are updated recursively with repeated traversals of the downwind methane plume when the vehicle was circling around the targeted facilities. Data from controlled tracer release experiments are presented and used to validate the approach. With access via public roads, this mobile monitoring method is able to quickly assess the emission strength of facilities along the sensor path. This work is developing the capacity for efficient regional coverage of potential methane emission rates in support of leak detection and mitigation efforts.

  19. Analysis article on the performance analysis of the OneTouch UltraVue blood glucose monitoring system. (United States)

    Solnica, Bogdan


    In this issue of Journal of Diabetes Science and Technology, Chang and colleagues present the analytical performance evaluation of the OneTouch UltraVue blood glucose meter. This device is an advanced construction with a color display, used-strip ejector, no-button interface, and short assay time. Accuracy studies were performed using a YSI 2300 analyzer, considered the reference. Altogether, 349 pairs of results covering a wide range of blood glucose concentrations were analyzed. Patients with diabetes performed a significant part of the tests. Obtained results indicate good accuracy of OneTouch UltraVue blood glucose monitoring system, satisfying the International Organization for Standardization recommendations and thereby locating >95% of tests within zone A of the error grid. Results of the precision studies indicate good reproducibility of measurements. In conclusion, the evaluation of the OneTouch UltraVue meter revealed good analytical performance together with convenient handling useful for self-monitoring of blood glucose performed by elderly diabetes patients.

  20. Reproducibility of transcutaneous oximetry and laser Doppler flowmetry in facial skin and gingival tissue. (United States)

    Svalestad, J; Hellem, S; Vaagbø, G; Irgens, A; Thorsen, E


    Laser Doppler flowmetry (LDF) and transcutaneous oximetry (TcPO(2)) are non-invasive techniques, widely used in the clinical setting, for assessing microvascular blood flow and tissue oxygen tension, e.g. recording vascular changes after radiotherapy and hyperbaric oxygen therapy. With standardized procedures and improved reproducibility, these methods might also be applicable in longitudinal studies. The aim of this study was to evaluate the reproducibility of facial skin and gingival LDF and facial skin TcPO(2). The subjects comprised ten healthy volunteers, 5 men, aged 31-68 years. Gingival perfusion was recorded with the LDF probe fixed to a custom made, tooth-supported acrylic splint. Skin perfusion was recorded on the cheek. TcPO(2) was recorded on the forehead and cheek and in the second intercostal space. The reproducibility of LDF measurements taken after vasodilation by heat provocation was greater than for basal flow in both facial skin and mandibular gingiva. Pronounced intraday variations were observed. Interweek reproducibility assessed by intraclass correlation coefficient ranged from 0.74 to 0.96 for LDF and from 0.44 to 0.75 for TcPO(2). The results confirm acceptable reproducibility of LDF and TcPO(2) in longitudinal studies in a vascular laboratory where subjects serve as their own controls. The use of thermoprobes is recommended. Repeat measurements should be taken at the same time of day.

  1. Reducing greenhouse gas emissions from deforestation in developing countries : considerations for monitoring and measuring

    Energy Technology Data Exchange (ETDEWEB)

    DeFries, R. [Maryland Univ., College Park, MD (United States); Achard, F. [Joint Research Centre of the European Commission, Ispra (Italy); Brown, S. [Winrock International, Arlington, VA (United States). Ecosystem Services Unit; Herold, M. [Friedrich Schiller Univ., Jena (Germany). Dept. of Geography, GOFC-GOLD Land Cover Office; Murdiyarso, D. [CIFOR Headquarters, Jakarta (Indonesia); Schlamadinger, B. [Joanneum Research, Graz (Austria); De Souza, C.Jr. [Inst. Homem e Meio Ambiente da Amazonia, Belem (Brazil)


    The removal of forest cover through deforestation is a primary contributor to greenhouse gas (GHG) emissions. This report presented technical considerations for the measurement and monitoring of GHG emissions reductions from avoided deforestation. The process of quantifying GHG emissions averted from reduced deforestation requires the measurement of changes in forest cover and carbon stocks using remotely sensed data from aircraft and satellite. Methods for analyzing satellite data for changes in forest cover ranged from visual photo-interpretation to digital analysis, hot spot analysis, and statistical sampling. The study showed that new technologies are now being developed for monitoring changes in forest carbon stocks. International coordination is needed to implement the technologies, which use a combination of satellite and airborne images to reduce uncertainties in accounting for changes in GHG emissions. Coordination is also needed to ensure adequate coverage of forests around the world as there is limited capacity in many developing countries to both acquire and analyze deforestation and degradation data. It was concluded that data from the 1990s are now being used as historical reference points. 38 refs., 2 tabs., 2 figs.

  2. Hierarchical leak detection and localization method in natural gas pipeline monitoring sensor networks. (United States)

    Wan, Jiangwen; Yu, Yang; Wu, Yinfeng; Feng, Renjian; Yu, Ning


    In light of the problems of low recognition efficiency, high false rates and poor localization accuracy in traditional pipeline security detection technology, this paper proposes a type of hierarchical leak detection and localization method for use in natural gas pipeline monitoring sensor networks. In the signal preprocessing phase, original monitoring signals are dealt with by wavelet transform technology to extract the single mode signals as well as characteristic parameters. In the initial recognition phase, a multi-classifier model based on SVM is constructed and characteristic parameters are sent as input vectors to the multi-classifier for initial recognition. In the final decision phase, an improved evidence combination rule is designed to integrate initial recognition results for final decisions. Furthermore, a weighted average localization algorithm based on time difference of arrival is introduced for determining the leak point's position. Experimental results illustrate that this hierarchical pipeline leak detection and localization method could effectively improve the accuracy of the leak point localization and reduce the undetected rate as well as false alarm rate.

  3. Experience of molecular monitoring techniques in upstream oil and gas operations

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Anthony F.; Anfindsen, Hilde; Liengen, Turid; Molid, Solfrid [Statoil ASA (Denmark)


    For a numbers of years, molecular monitoring tools have been used in upstream oil and gas operations but the results have given only limited added value. This paper discusses the various techniques available for upstream molecular monitoring which provides scope for identification of microbial influenced problems. The methodology, which consists of analyzing solid samples using traditional as well as molecular techniques, is detailed. Two cases were studied with the objective of determining if microbial contamination was contributing to the problem. The first case was a study of amorphous deposits in production wells and mainly iron sulphide was found. The second study was of amorphous deposits in water injection wells and the analysis showed typical components of drilling and completion fluids with some organic material. Two more cases, corrosion of tubing in a water injection well and flow line corrosion, are discussed and the results are given. From the study, it can be concluded that failure can be due to several factors, chemical and biological.

  4. Tunable Diode Laser Sensors to Monitor Temperature and Gas Composition in High-Temperature Coal Gasifiers

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, Ronald [Stanford Univ., CA (United States); Whitty, Kevin [Univ. of Utah, Salt Lake City, UT (United States)


    The integrated gasification combined cycle (IGCC) when combined with carbon capture and storage can be one of the cleanest methods of extracting energy from coal. Control of coal and biomass gasification processes to accommodate the changing character of input-fuel streams is required for practical implementation of integrated gasification combined-cycle (IGCC) technologies. Therefore a fast time-response sensor is needed for real-time monitoring of the composition and ideally the heating value of the synthesis gas (here called syngas) as it exits the gasifier. The goal of this project was the design, construction, and demonstration an in situ laserabsorption sensor to monitor multiple species in the syngas output from practical-scale coal gasifiers. This project investigated the hypothesis of using laser absorption sensing in particulateladen syngas. Absorption transitions were selected with design rules to optimize signal strength while minimizing interference from other species. Successful in situ measurements in the dusty, high-pressure syngas flow were enabled by Stanford’s normalized and scanned wavelength modulation strategy. A prototype sensor for CO, CH4, CO2, and H2O was refined with experiments conducted in the laboratory at Stanford University, a pilot-scale at the University of Utah, and an engineering-scale gasifier at DoE’s National Center for Carbon Capture with the demonstration of a prototype sensor with technical readiness level 6 in the 2014 measurement campaign.

  5. Transcutaneous electric nerve stimulation (TENS) in dentistry- A review. (United States)

    Kasat, Vikrant; Gupta, Aditi; Ladda, Ruchi; Kathariya, Mitesh; Saluja, Harish; Farooqui, Anjum-Ara


    Transcutaneous electric nerve stimulation (TENS) is a non-pharmacological method which is widely used by medical and paramedical professionals for the management of acute and chronic pain in a variety of conditions. Similarly, it can be utilized for the management of pain during various dental procedures as well as pain due to various conditions affecting maxillofacial region. This review aims to provide an insight into clinical research evidence available for the analgesic and non analgesic uses of TENS in pediatric as well as adult patients related to the field of dentistry. Also, an attempt is made to briefly discuss history of therapeutic electricity, mechanism of action of TENS, components of TENs equipment, types, techniques of administration, advantages and contradictions of TENS. With this we hope to raise awareness among dental fraternity regarding its dental applications thereby increasing its use in dentistry. Key words:Dentistry, pain, TENS.

  6. Deqi Sensations of Transcutaneous Electrical Nerve Stimulation on Auricular Points

    Directory of Open Access Journals (Sweden)

    Xiaoling Wang


    Full Text Available Deqi sensation, a psychophysical response characterized by a spectrum of different needling sensations, is essential for Chinese acupuncture clinical efficacy. Previous research works have investigated the component of Deqi response upon acupuncture on acupoints on the trunk and limbs. However, the characteristics of Deqi sensations of transcutaneous electrical nerve stimulation (TENS on auricular points are seldom reported. In this study, we investigated the individual components of Deqi during TENS on auricular concha area and the superior scapha using quantitative measurements in the healthy subjects and depression patients. The most striking characteristics of Deqi sensations upon TENS on auricular points were tingling, numbness, and fullness. The frequencies of pressure, warmness, heaviness, and soreness were relatively lower. The dull pain and coolness are rare. The characteristics of Deqi were similar for the TENS on concha and on the superior scapha.

  7. Electrochemical sensor for continuous transcutaneous PCO2 measurement. (United States)

    Beran, A V; Huxtable, R F; Sperling, D R


    A sensor suitable for continuous transcutaneous PCO2 measurements is described. The sensor consists of an antimony-antimony oxide electrode in combination with a silver-silver chloride reference electrode, bathed in an electrolyte and covered by a Teflon membrane. A servo-controlled heater unit was used to maintain the sensor's temperature and to produce local hyperemia. The resulting oxidation-reduction potential under constant temperature is a linear function of the logarithm PCO2. Response time (95%) to step changes in PCO2 from 27 to 70 mmHg was 2.7 +/- 0.3 min. Following a 12-h "aging" time, the electrode exhibited a minimal drift of 5.2 +/- 2.2 mV for 16 h, representing an average PCO2 drift of 0.5 mmHg/h. This sensor was applied on three rabbits and on five human volunteers, and found satisfactory under normal physiological conditions.

  8. Validation of the Oregon Scientific BPU 330 for self-monitoring of blood pressure according to the International Protocol

    Directory of Open Access Journals (Sweden)

    Li Li


    Full Text Available Li Li1, XinYu Zhang1, ChunHong Yan1, QingXiang Liang21Biomedical Engineering Lab, Faculty of Information Engineering, ShenZhen University, ShenZhen, China; 2Bao An People’s Hospital, ShenZhen, ChinaObjective: Extensive marketing of devices for self-measurement of blood pressure has created a need for purchasers to be able to satisfy themselves that such devices have been evaluated according to agreed criteria. The Oregon Scientific BPU 330 blood pressure monitor is an electronic device for upper arm measurement. This study assessed the accuracy of the Oregon Scientific BPU 330 blood pressure monitor according to the International Protocol by the Working Group on Blood Pressure Monitoring of the European Society of Hypertension for validation of blood pressure measuring devices.Method: 52 participants over 30 years of age were studied in the validation. Nine blood pressure measurements were taken alternately with a mercury sphygmomanometer by two observers, and by the supervisor, using the BPU 330 device. A total of 33 participants were selected for the analysis. The validation was divided into two phases. Phase 1 included 15 participants. If the device passed phase 1, 18 more participants were included. The 99 pairs of measurements were compared according to the International Protocol. The device was given a pass/fail recommendation based on its accuracy compared with the mercury standard (within 5, 10, and 15 mmHg, as well as the number met in the ranges specified by the International Protocol.Results: The mean and standard deviation of the difference between the mean of the observers and the BPU 330 device were 1.7 ± 4.7 mmHg and 2.8 ± 3.9 mmHg for systolic blood pressure (SBP and diastolic blood pressure (DBP, respectively. In phase 1, the device passed with a total of 33, 43, and 44 SBP readings; 38, 44, and 45 DBP readings were within 5, 10, and 15 mmHg, respectively. In phase 2.1, 81, 95, and 96 for SBP, and 83, 95, and 98 for DBP

  9. A fence line noble gas monitoring system for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Grasty, R.L.; Hovgaard, J.; LaMarre, J.R


    A noble gas monitoring system has been installed at Ontario Power Generations' Pickering Nuclear Generating Station (PNGS) near Toronto, Canada. This monitoring system allows a direct measure of air kerma from external radiation instead of calculating this based on plant emission data and meteorological models. This has resulted in a reduction in the reported effective dose from external radiation by a factor of at least ten. The system consists of nine self-contained units, each with a 7.6 cm x 7.6 cm (3 inch x 3 inch) NaI(Tl) detector that is calibrated for air kerma. The 512-channel gamma ray spectral information is downloaded daily from each unit to a central computer where the data are stored and processed. A spectral stripping procedure is used to remove natural background variations from the spectral windows used to monitor xenon-133 ({sup 133}Xe), xenon-135 ({sup 135}Xe), argon-41 ({sup 41}Ar), and skyshine radiation from the use of radiography sources. Typical monthly minimum detection limits in air kerma are 0.3 nGy for {sup 133}Xe, 0.7 nGy for {sup 135}Xe, 3 nGy for {sup 41}Ar and 2 nGy for skyshine radiation. Based on 9 months of continuous operation, the annualised air kerma due to {sup 133}Xe, {sup 135}Xe and {sup 41}Ar and skyshine radiation were 7 nGy, 8 nGy, 26 nGy and 107 nGy respectively. (author)

  10. Blood pressure, acid-base and blood gas status and indicators of oxidative stress in healthy male rats exposed to acute hyperbaric oxygenation. (United States)

    Drenjancevic, Ines; Kibel, Aleksandar; Kibel, Dijana; Seric, Vatroslav; Cosic, Anita


    Different protocols of hyperbaric oxygenation (HBO2) are used for research purposes; however, data on the changes in blood pressure, oxidative stress and acid-base and gas status induced by various oxygenation protocols are scarce and conflicting. The aim of this study was to examine the effects of an acute session of HBO2 [2 bar (200 kPa) for two hours] on arterial systolic and diastolic blood pressure, arterial blood gases and acid-base status, and oxidative stress in rats. Sprague-Dawley rats (12-15 weeks) were examined prior to, immediately and 24 hours after a two-hour HBO2 exposure at 2 bars. The femoral artery was cannulated to determine blood pressure, and blood samples were collected to measure blood gases and acid-base status, Ferric reducing antioxidant power ability of plasma (FRAP) and thiobarbituric acid reactive substances (TBARS). Immediately after HBO2 systolic and diastolic blood pressure significantly decreased (from 138 +/- 14/103 +/- 13 to 113 +/- 12/72 +/- 16 mmHg). However, these values were still inside the normal physiological range. pH decreased (from 7.34 +/- 0.05 to 7.28 +/- 0.05), pCO2 decreased (from 7.07 +/- 0.89 to 5.76 +/- 0.50 kPa), pO2 increased (from 12.48 +/- 0.88 to 13.68 +/- 2.4 kPa), plasma bicarbonate decreased (from 27.04 +/- 3.25 to 20.52 +/- 3.02 mmol/L). Exposure to HBO2 immediately increased TBARS levels (from 0.17 +/- 0.09 to 21.79 +/- 1.05 microM/MDA), while FRAP levels were not significantly changed. Measurements on separate animals 24 hours after a single HBO2 exposure showed no differences in comparison to control animals, except for pO2, which was significantly lower (11.10 +/- 0.31 kPa). The results define values of important parameters, serving as a necessary basis for complex analysis of HBO2 effects in research on rat animal models.

  11. A novel artificial anal sphincter system based on transcutaneous energy transmission

    Institute of Scientific and Technical Information of China (English)

    Zan Peng; Yan Guozheng; Liu Hua


    For controlling anal incontinence, a new artificial anal sphincter system (AASS) with sensor feedback based on transcutaneous energy transmission is developed. The device mainly comprises an artificial anal sphincter (AAS), a wireless power supply subsystem, and a communication subsystem. The artificial anal sphincter comprises a front cuff and a sensor cuff placed around the rectum, a reservoir sited in abdominal cavity and a micropump controlling inflation and deflation of the front cuff. There are two pressure sensors in the artificial anal sphincter. One can measure the pressure in the front cuff to clamp the rectum, the other in the sensor cuff can measure the pressure of the rectum. Wireless power supply subsystem includes a resonance transmit coil to transmit an alternating magnetic field and a secondary coil to receive the power. Wireless communication subsystem can transmit the pressure information of the artificial anal sphincter to the monitor, or send the control commands to the artificial anal sphincter. A prototype is designed and the basic function of the artificial anal sphincter system has been tested through experiments. The results demonstrate that the artificial anal sphincter system can control anal incontinence effectively.

  12. Strategies for Detecting Hidden Geothermal Systems by Near-Surface Gas Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Lewicki, Jennifer L.; Oldenburg, Curtis M.


    ''Hidden'' geothermal systems are those systems above which hydrothermal surface features (e.g., hot springs, fumaroles, elevated ground temperatures, hydrothermal alteration) are lacking. Emissions of moderate to low solubility gases (e.g., CO2, CH4, He) may be one of the primary near-surface signals from these systems. Detection of anomalous gas emissions related to hidden geothermal systems may therefore be an important tool to discover new geothermal resources. This study investigates the potential for CO2 detection and monitoring in the subsurface and above ground in the near-surface environment to serve as a tool to discover hidden geothermal systems. We focus the investigation on CO2 due to (1) its abundance in geothermal systems, (2) its moderate solubility in water, and (3) the wide range of technologies available to monitor CO2 in the near-surface environment. However, monitoring in the near-surface environment for CO2 derived from hidden geothermal reservoirs is complicated by the large variation in CO2 fluxes and concentrations arising from natural biological and hydrologic processes. In the near-surface environment, the flow and transport of CO2 at high concentrations will be controlled by its high density, low viscosity, and high solubility in water relative to air. Numerical simulations of CO2 migration show that CO2 concentrations can reach very high levels in the shallow subsurface even for relatively low geothermal source CO2 fluxes. However, once CO2 seeps out of the ground into the atmospheric surface layer, surface winds are effective at dispersing CO2 seepage. In natural ecological systems in the absence of geothermal gas emissions, near-surface CO2 fluxes and concentrations are primarily controlled by CO2 uptake by photosynthesis, production by root respiration, and microbial decomposition of soil/subsoil organic matter, groundwater degassing, and exchange with the atmosphere. Available technologies for monitoring CO2 in

  13. Natural Gas Storage Seismic Monitoring Suivi sismique des stockages de gaz naturel

    Directory of Open Access Journals (Sweden)

    Mari J.L.


    Full Text Available IFP Energies nouvelles, CGGVeritas and GDF Suez have conducted together, since 1980, a series of seismic monitoring experiments in order to detect and follow the movements of the gas plume in natural gas geologic storages. Surface and well seismic surveys were carried out at different stages of the storage life. Permanent receiver arrays have been set down in wells. Permanent sources have been designed. Sources and receivers have been used to follow continuously the storage cycle during several years, providing time measurement accuracy within a tenth of a millisecond. Gas intrusion into an aquifer leads to an increase in the arrival times of reflections beneath the storage reservoir and to a variation of the reflection amplitudes at top and bottom of the reservoirs. Progressive variations of the seismic parameters may be followed during the initial infill period. Further movements of the gas plume with the annual in/out cycles are more difficult to follow, because of the simultaneous presence of gas and water in the pores. Arrival time variations of some tenths of a millisecond may be detected and measured. Saturations, using accurate picking of the arrival times, can be estimated in favourable cases. Because of the higher density of carbon dioxide, when stored in a supercritical phase, sensitivity of the seismic parameters, velocity, density and acoustic impedance to saturation variations will be about twice smaller for CO2 storages than it is for methane. IFP Energies nouvelles, la CGGVeritas et GDF Suez ont mené ensemble, depuis 1980, de nombreuses expériences de monitoring sismique afin de détecter et de suivre les mouvements du gaz dans des stockages géologiques de gaz naturel. Des acquisitions ont été réalisées à différents stades de la vie du stockage tant en sismique de surface qu’en sismique de puits. Des antennes de récepteurs permanentes ont été construites et implantées dans des puits. Des sources permanentes ont

  14. Monitoring in microvascular surgery. (United States)

    Furnas, H; Rosen, J M


    The importance of monitoring in microvascular surgery is underscored by the high reported salvage rates of failing free flaps and replants. In this overview, we begin by defining the physiology of ischemic tissue with emphasis given to the no-reflow phenomenon and the secondary critical ischemia times. Based on the physiological changes accompanying ischemia, several variables are defined that can be monitored to reflect the vascular state of a free flap or replant. Multifarious monitoring systems are then reviewed, including clinical observation, temperature, isotope clearance, ultrasonic Doppler, laser Doppler, transcutaneous oxygen tension, reflection plethysmography, dermofluorometry, pH, electromagnetic flowmetry, serial hematocrits, interstitial fluid pressure, and magnetic resonance imaging.

  15. Application network for monitoring of green house gas emission from lithosphere in Khibina territories (United States)

    Asavin, Alex; Nivin, Valentin; Litvinov, Artur; Chesalova, Elena; Baskov, Sergey


    The aim of project is to estimate the contribution of lithospheric flue gas emission of gases CH4, CO2, H2 in the general composition of atmospheric pollution of Arctic zone. The main task is organization of the ecological monitoring in the area of exploitation of large apatite and rare earth ore deposit from Khibine massive on the base of modern WSN (wireless sensor network) technologies. Application network consist from sensors of gas H2, CH4, CO2, complex autonomous equipment for measurement temperature, pressure, humidity and network of telecommunications (used ZigBee protocol). Our project offer technical decisions for experimentally-methodical monitoring network on the base of WSN and the high-sensitive sensors of hydrogen and methane, software and electronic equipment with a transmitter network. This work is the first project in Russia. The advantages of this technology is autonomous work (to several months and more), high-frequency programmable measurement of gas sensor, low cost (on one node of network), possibility to connect to one node of supervision a several types of sensors. And as a result is complex monitoring of environment. It has long been known that the pollution in Arctic Khibine and Lovosero region contains unusually high levels of hydrocarbon gases (HCG) [Petersilie,1964]. The presence of these gases has a number of practical implications and it is therefore important to understand their source and distribution. Among alkaline intrusive complexes with high (for magmatic rocks) concentrations of hydrocarbon and hydrogen- hydrocarbon gases occluded as fluid inclusions in minerals. The Khibina and Lovozero massives are well known, as region of spontaneous emissions of these gases from lithosphere [Khitarov et al., 1979; Ikorskii et al., 1992; Beeskow 2007; Nivin 2005, 2009]. The presence of the HCG, however, raises a number of questions and possibilities. It is unclear how homogeneously the HCG are distributed through the complex? What is the

  16. A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations

    DEFF Research Database (Denmark)

    Celsis, P; Goldman, T; Henriksen, L;


    of four 1 min pictures and using a fixed value for the brain:blood partition coefficient, lambda. The method is essentially based on the bolus distribution principle, and it allows the estimation of blood flow in ischemic areas. Application to positron emission tomography is discussed....

  17. Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry. (United States)

    Habrdova, Vilma; Peters, Frank T; Theobald, Denis S; Maurer, Hans H


    In recent years, several newer designer drugs of the so-called 2C series such as 2C-D, 2C-E, 2C-P, 2C-B, 2C-I, 2C-T-2, and 2C-T-7 have entered the illicit drug market as recreational drugs. Some fatal intoxications involving 2C-T-7 have been reported. Only scarce data have been published about analyses of these substances in human blood and/or plasma. This paper describes a method for screening and simultaneous quantification of the above-mentioned compounds and their analog mescaline in human blood plasma. The analytes were analyzed by gas chromatography/mass spectrometry in the selected-ion monitoring mode, after mixed-mode solid-phase extraction (HCX) and derivatization with heptafluorobutyric anhydride. The method was fully validated according to international guidelines. Validation data for 2C-T-2 and 2C-T-7 were unacceptable. For all other analytes, the method was linear from 5 to 500 microg/L and the data for accuracy (bias) and precision (coefficient of variation) were within the acceptance limits of +/-15% and <15%, respectively (within +/-20% and <20% near the limit of quantification of 5 microg/L).

  18. Ultrasound-assisted dispersive liquid-liquid microextraction for the determination of seven recreational drugs in human whole blood using gas chromatography-mass spectrometry. (United States)

    Lin, Zebin; Li, Jiaolun; Zhang, Xinyu; Qiu, Meihong; Huang, Zhibin; Rao, Yulan


    Recreational drugs have large impact on public health and security, and to monitor them is of urgent demand. In the present study, ultrasound-assisted dispersive liquid-liquid microextraction combined with the detection of gas chromatography-mass spectrometry was applied to the determination of seven common recreational drugs, including amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, meperidine, methadone and ketamine in 200μL of human whole blood. A series of factors which would affect the extraction efficiency were systematically investigated, including the nature and the volume of extraction and dispersing solvents, ultrasonication time, salting-out effect and pH value. The method consumed small amount of sample. The limits of detection and limits of quantification for each analyte were 10 and 40ng/mL, respectively, and the linearity was in the range of 0.04-25μg/mL (R(2) higher than 0.99). Good specificity, precision (1.5-8.2% for the intra-day study and 2.6-12.8% for the inter-day study), satisfactory accuracy (85.0-117.1%) and extraction recovery (77.0-92.4%) were obtained, which makes it a high performance method for the determination of recreational drugs in human whole blood samples.

  19. Validated Method for the Quantification of Buprenorphine in Postmortem Blood Using Solid-Phase Extraction and Two-Dimensional Gas Chromatography-Mass Spectrometry. (United States)

    Nahar, Limon Khatun; Andrews, Rebecca; Paterson, Sue


    A highly sensitive and fully validated method was developed for the quantification of buprenorphine in postmortem blood. After a two-step protein precipitation process using acetonitrile, buprenorphine was purified using mixed-mode (C8/cation exchange) solid-phase extraction cartridges. Endogenous water-soluble compounds and lipids were removed from the cartridges before the samples were eluted, concentrated and derivatized using N-methyl-N-trimethylsilyltrifluoroacetamide. The samples were analyzed using two-dimensional gas chromatography-mass spectrometry (2D GC-MS) in selective ion-monitoring mode. A low polarity Rxi(®)-5MS (30 m × 0.25 mm I.D. × 0.25 µm) was used as the primary column and the secondary column was a mid-polarity Rxi(®) -17Sil MS (15 m × 0.32 mm I.D. × 0.25 µm). The assay was linear from 1.0 to 50.0 ng/mL (r(2) > 0.99; n = 6). Intraday (n = 6) and interday (n = 9) imprecisions (percentage relative standard deviation, % RSD) were selective with no interference from endogenous compounds or from 62 commonly encountered drugs. To prove method applicability to forensic postmortem cases, 14 authentic postmortem blood samples were analyzed.

  20. Determination of eight selected organophosphorus insecticides in postmortem blood samples using solid-phase extraction and gas chromatography/mass spectrometry. (United States)

    Raposo, R; Barroso, M; Fonseca, S; Costa, S; Queiroz, J A; Gallardo, E; Dias, M


    A simple, rapid and sensitive method is described for the determination of omethoate, dimethoate, diazinon, chlorpyrifos, parathion-ethyl, chlorfenvinphos, quinalphos and azinphos-ethyl in postmortem whole blood samples. The analytes and internal standard (ethion) were isolated from the matrix by solid-phase extraction, and were analysed by gas chromatography/mass spectrometry in the selected ion monitoring mode. The method has shown to be selective after analysis of postmortem samples of 40 different origins. Calibration curves were established between 0.05 (0.1 for omethoate) and 25 µg/mL, and the values obtained for intra- and interday precision and accuracy were within the criteria usually accepted for bioanalytical method validation. Lower limits of quantitation were 50 ng/mL for all compounds, except for omethoate (100 ng/mL); the limits of identification of the method were 25 ng/mL for all analytes, except for omethoate, for which 50 ng/mL was obtained. Absolute recovery was determined at three concentration levels, and ranged from 31 to 108%. The proposed method is simple and fast, and can be routinely applied in the determination of these compounds in postmortem whole blood samples within the scope of forensic toxicology. In addition, mass spectrometry has demonstrated to be a powerful and indispensable tool for the unequivocal identification of the analytes, since the acceptance criteria were accomplished even at very low levels, thus allowing obtaining forensically valid and sound results.

  1. The relationship between blood and muscle samples to monitor for residues of the antibiotic enrofloxacin in chickens. (United States)

    Reyes-Herrera, I; Schneider, M J; Blore, P J; Donoghue, D J


    In 2005, the US Food and Drug Administration withdrew approval for use of enrofloxacin in poultry, thus effectively imposing zero tolerance for residues of this antibiotic in poultry. Conventional residue monitoring for most antibiotics, including enrofloxacin, involves removing poultry carcasses from the processing line and collecting muscle tissues for analysis. Because of the loss of valuable edible products and the difficulties and expense of sampling all the carcasses, only a small portion of carcasses are tested for violative residues. Unlike muscle tissue, blood is readily available from all birds at the beginning of processing and may be used to screen for illegal residues in all poultry carcasses. It is unknown, however, if enrofloxacin concentrations in blood are predictive of muscle concentrations. In an effort to evaluate this relationship, 156 broiler chickens, 5 wk of age, were dosed with either 25 or 50 µg/mL of enrofloxacin for 3 or 7 d, respectively, in the drinking water. Blood and muscle samples were collected at 0, 1, 3, 6, 12, and 24 h (n = 6 birds/group) during the first dosing day, every 48 h during the dosing period, and every 12 h during the withdrawal period for up to 60 h after withdrawal. Enrofloxacin residues were determined in all blood and tissue samples during the dosing periods and in most of the withdrawal period for both doses. These results support the potential to use blood to screen for illegal enrofloxacin residues in edible poultry tissues in an effort to protect the human food supply.

  2. Surrogate testing suggests that chlorine dioxide gas exposure would not inactivate Ebola virus contained in environmental blood contamination. (United States)

    Lowe, John J; Hewlett, Angela L; Iwen, Peter C; Smith, Philip W; Gibbs, Shawn G


    The ability to decontaminate a room potentially containing the Ebola virus is important to healthcare facilities in the United States. Ebola virus remains viable in body fluids, a room that has housed a patient with Ebola virus disease must have all surfaces manually wiped with an approved disinfectant, which increases occupational exposure risk. This study evaluated the efficacy of gaseous chlorine dioxide inactivation of bacterial organisms in blood as Ebola virus surrogates and as the organisms used by the Nebraska Biocontainment Unit to provide the margin of safety for decontamination. Bacillus anthracis, Escherichia coli, Enterococcus faecalis, and Mycobacterium smegmatis blood suspensions that were exposed to ClO2 gas concentrations and exposure limits. The log reduction in Colony Forming Units (CFU) was determined for each bacterial blood suspension. Exposure parameters approximating industry practices for ClO2 environmental decontamination (360ppm concentration to 780 ppm-hrs exposure, 65% relative humidity) as well as parameters exceeding current practice (1116 ppm concentration to 1400 ppm-hrs exposure; 1342ppm concentration to 1487 ppm-hrs exposure) were evaluated. Complete inactivation was not achieved for any of the bacterial blood suspensions tested. Reductions were observed in concentrations of B. anthracis spores (1.3 -3.76 log) and E. faecalis vegetative cells (1.3 log) whereas significant reductions in vegetative cell concentrations for E. coli and M. smegmatis blood suspensions were not achieved. Our results showed that bacteria in the presence of blood were not inactivated using gaseous ClO2 decontamination. ClO2 decontamination alone should not be used for Ebola virus, but decontamination processes should first include manual wiping of potentially contaminated blood; especially for microorganisms as infectious as the Ebola virus.

  3. Ultra-sensitive method for determination of ethanol in whole blood by headspace capillary gas chromatography with cryogenic oven trapping. (United States)

    Watanabe-Suzuki, K; Seno, H; Ishii, A; Kumazawa, T; Suzuki, O


    We have established an ultra-sensitive method for determination of ethanol in whole blood by headspace capillary gas chromatography (GC) with cryogenic oven trapping. After heating a blood sample containing ethanol and isobutyl alcohol (internal standard, IS) in a 7.0-ml vial at 55 degrees C for 15 min, 5 ml of the headspace vapor was drawn into a glass syringe and injected into a GC port. All vapor was introduced into an Rtx-BAC2 wide-bore capillary column in the splitless mode at -60 degrees C oven temperature to trap entire analytes, and then the oven temperature was programmed up to 240 degrees C for GC measurements with flame ionization detection. The present method gave sharp peaks of ethanol and IS, and low background noise for whole blood samples. The mean partition into the gaseous phase for ethanol and IS was 3.06+/-0.733 and 8.33+/-2.19%, respectively. The calibration curves showed linearity in the range 0.02-5.0 microg/ml whole blood. The detection limit was estimated to be 0.01 microg/ml. The coefficients of intra-day and inter-day variation for spiked ethanol were 8.72 and 9.47%, respectively. Because of the extremely high sensitivity, we could measure low levels of endogenous ethanol in whole blood of subjects without drinking. The concentration of endogenous ethanol measured for 10 subjects under uncontrolled conditions varied from 0 to 0.377 microg/ml (mean, 0.180 microg/ml). Data on the diurnal changes of endogenous ethanol in whole blood of five subjects under strict food control are also presented; they are in accordance with the idea that endogenous blood ethanol is of enteric bacterial origin.

  4. Strict Blood Pressure Control Achieved Using an ICT-Based Home Blood Pressure Monitoring System in a Catastrophically Damaged Area After a Disaster. (United States)

    Nishizawa, Masafumi; Hoshide, Satoshi; Okawara, Yukie; Matsuo, Takefumi; Kario, Kazuomi


    At the time of the Great East Japan earthquake and tsunami (March 2011), the authors developed a web-based information and communications technology (ICT)-based blood pressure (BP) monitoring system (the Disaster CArdiovascular Prevention [DCAP] Network) and introduced it in an area that was catastrophically damaged (Minamisanriku town) to help control the survivors' BP. Using this system, home BP (HBP) was monitored and the data were automatically transmitted to a central computer database and to the survivors' attending physicians. The study participants, 341 hypertensive patients, continued to use this system for 4 years after the disaster and all of the obtained HBP readings were analyzed. This DCAP HBP-guided approach helped achieve a decrease in the participants' HBPs (initial average: 151.3±20.0/86.9±10.2 mm Hg to 120.2±12.1/70.8±10.2 mm Hg) over the 4 years. In addition, the amplitude of seasonal BP variation was suppressed and the duration from the summer lowest HBP values to the winter peak HBP values was gradually prolonged. This ICT-based approach was useful to achieve strict HBP control and minimize the seasonal BP variation even in a catastrophically damaged area during a 4-year period after the disaster, suggesting that this approach could be a routine way to monitor BP in the community.

  5. Clinical significance of ambulatory blood pressure monitoring%动态血压监测及其临床价值

    Institute of Scientific and Technical Information of China (English)

    孙乐; 于宪一


    Ambulatory blood pressure monitoring(ABPM)system can record patients blood pressure of 24 h on the predetermined time. The primary data forms the graph,the curve and the general report by operation of the related software after the analysis and statistics processing. Patients keep daily life condition,so the blood pressure data is more accuracy. ABPM can provide the dynamic change of the patients 24 h blood pressure,including the 24 h blood pressure survey data,the undulation situation and the change tendency. ABPM has become an useful element in the evaluation and follow - up of hypertension in adults. And ABPM is increasingly used to evaluate the blood pressure of children and adolescents in recent years. The ABPM has been shown to differ significantly values.%动态血压监测(ambulatory blood pressure monitoring,ABPM)是通过血压记录仪自动操作,在预定的时间点记录受检者日常生活状态下的血压,经相关的软件程序对原始数据进行分析和统计学处理后,形成图表、曲线和综合报告。ABPM 能提供24 h 血压测量数据、波动情况及变化趋势,能全面地反映患者24 h 血压的动态变化,近年来已经开始在儿科广泛应用,在高血压的诊断、治疗、预后评估及随访等多方面研究中均具有重要作用。

  6. Overview of microseismic monitoring of hydraulic fracturing for unconventional oil and gas plays (United States)

    Shemeta, J. E.


    The exponential growth of unconventional resources for oil and gas production has been driven by the use of horizontal drilling and hydraulic fracturing. These drilling and completion methods increase the contact area of the low permeability and porosity hydrocarbon bearing formations and allow for economic production in what was previously considered uncommercial rock. These new resource plays have sparked an enormous interest in microseismic monitoring of hydraulic fracture treatments. As a hydraulic fracture is pumped, microseismic events are emitted in a volume of rock surrounding the stimulated fracture. The goal of the monitoring is to identify and locate the microseismic events to a high degree of precision and to map the position of the induced hydraulic fracture in time and space. The microseismic events are very small, typically having a moment-magnitude range of -4 to 0. The microseismic data are collected using a variety of seismic array designs and instrumentation, including borehole, shallow borehole, near-surface and surface arrays, using either of three-component clamped 15 Hz borehole sondes to simple vertical 10 Hz geophones for surface monitoring. The collection and processing of these data is currently under rapid technical development. Each monitoring method has technical challenges which include accurate velocity modeling, correct seismic phase identification and signal to noise issues. The microseismic locations are used to guide hydrocarbon exploration and production companies in crucial reservoir development decisions such as the direction to drill the horizontal well bores and the appropriate inter-well spacing between horizontal wells to optimally drain the resource. The fracture mapping is also used to guide fracture and reservoir engineers in designing and calibrating the fluid volumes and types, injection rates and pressures for the hydraulic fracture treatments. The microseismic data can be located and mapped in near real-time during

  7. The correlation and level of agreement between end-tidal and blood gas pCO2 in children with respiratory distress: a retrospective analysis

    Directory of Open Access Journals (Sweden)

    Alexander Jamin L


    Full Text Available Abstract Background To investigate the correlation and level of agreement between end-tidal carbon dioxide (EtCO2 and blood gas pCO2 in non-intubated children with moderate to severe respiratory distress. Methods Retrospective study of patients admitted to an intermediate care unit (InCU at a tertiary care center over a 20-month period with moderate to severe respiratory distress secondary to asthma, bronchiolitis, or pneumonia. Patients with venous pCO2 (vpCO2 and EtCO2 measurements within 10 minutes of each other were eligible for inclusion. Patients with cardiac disease, chronic pulmonary disease, poor tissue perfusion, or metabolic abnormalities were excluded. Results Eighty EtCO2-vpCO2 paired values were available from 62 patients. The mean ± SD for EtCO2 and vpCO2 was 35.7 ± 10.1 mmHg and 39.4 ± 10.9 mmHg respectively. EtCO2 and vpCO2 values were highly correlated (r = 0.90, p SD between EtCO2 and vpCO2 was -3.68 ± 4.70 mmHg. The 95% level of agreement ranged from -12.88 to +5.53 mmHg. EtCO2 was found to be more accurate when vpCO2 was 35 mmHg or lower. Conclusion EtCO2 is correlated highly with vpCO2 in non-intubated pediatric patients with moderate to severe respiratory distress across respiratory illnesses. Although the level of agreement between the two methods precludes the overall replacement of blood gas evaluation, EtCO2 monitoring remains a useful, continuous, non-invasive measure in the management of non-intubated children with moderate to severe respiratory distress.

  8. Continuous monitoring of absolute cerebral blood flow by combining diffuse correlation spectroscopy and time-resolved near-infrared technology (United States)

    Diop, Mamadou; Lee, Ting-Yim; St. Lawrence, Keith


    Continuous bedside monitoring of cerebral blood flow (CBF) in patients recovering from brain injury could improve the detection of impaired substrate delivery, which can exacerbate injury and worsen outcome. Diffuse correlation spectroscopy (DCS) provides the ability to monitor perfusion changes continuously, but it is difficult to quantify absolute blood flow - leading to uncertainties as to whether or not CBF has fallen to ischemic levels. To continuously measure CBF, we propose to calibrate DCS data using a single time-point, time-resolved near-infrared (TR-NIR) technique for measuring absolute CBF. Experiments were conducted on newborn piglets in which CBF was increased by raising the arterial tension of CO2 (40-62 mmHg) and decreased by carotid occlusion. For validation, values of CBF measured by TR-NIR were converted into blood flow changes and compared to CBF changes measured by DCS. A strong correlation between perfusion changes from the two techniques was revealed (slope = 0.98 and R2 = 0.96), suggesting that a single time-point CBF measurement by TR-NIR can be used to convert continuous DCS data into units of CBF (ml/100g/min).

  9. A greenhouse-gas information system monitoring and validating emissions reporting and mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Jonietz, Karl K [Los Alamos National Laboratory; Dimotakis, Paul E [JPL/CAL TECH; Roman, Douglas A [LLNL; Walker, Bruce C [SNL


    Current GHG-mitigating regimes, whether internationally agreed or self-imposed, rely on the aggregation of self-reported data, with limited checks for consistency and accuracy, for monitoring. As nations commit to more stringent GHG emissions-mitigation actions and as economic rewards or penalties are attached to emission levels, self-reported data will require independent confirmation that they are accurate and reliable, if they are to provide the basis for critical choices and actions that may be required. Supporting emissions-mitigation efforts and agreements, as well as monitoring energy- and fossil-fuel intensive national and global activities would be best achieved by a process of: (1) monitoring of emissions and emission-mitigation actions, based, in part, on, (2) (self-) reporting of pertinent bottom-up inventory data, (3) verification that reported data derive from and are consistent with agreed-upon processes and procedures, and (4) validation that reported emissions and emissions-mitigation action data are correct, based on independent measurements (top-down) derived from a suite of sensors in space, air, land, and, possibly, sea, used to deduce and attribute anthropogenic emissions. These data would be assessed and used to deduce and attribute measured GHG concentrations to anthropogenic emissions, attributed geographically and, to the extent possible, by economic sector. The validation element is needed to provide independent assurance that emissions are in accord with reported values, and should be considered as an important addition to the accepted MRV process, leading to a MRV&V process. This study and report focus on attributes of a greenhouse-gas information system (GHGIS) needed to support MRV&V needs. These needs set the function of such a system apart from scientific/research monitoring of GHGs and carbon-cycle systems, and include (not exclusively): the need for a GHGIS that is operational, as required for decision-support; the need for a

  10. Development of a telecare system based on ZigBee mesh network for monitoring blood pressure of patients with hemodialysis in health care centers. (United States)

    Du, Yi-Chun; Lee, You-Yun; Lu, Yun-Yuan; Lin, Chia-Hung; Wu, Ming-Jei; Chen, Chung-Lin; Chen, Tainsong


    In Taiwan, the number of the patients needing dialysis increases rapidly in recent years. Because there is risk in every hemodialysis session, monitoring physiological status, such as blood pressure measurement every 30 min to 1 h is needed during about 4 h hemodialysis process. Therefore, an assisted measurement on blood pressure is needful in dialysis care centers. Telecare system (TCS) is regarded as one of important technique in the medical care. In this study, we utilized ZigBee wireless technique to establish a mesh network for monitoring blood pressure automatically and data storage in medical record system for display and further analysis. Moreover, while the blood pressure exceeds the normal range, the system could send a warning signal to remind, or inform the relatives and clinicians in health care center through the personal handy-phone system (PHS) immediately. The proposed system provides an assisted device for monitoring patients' blood pressure during hemodialysis process and saving medical manpower.

  11. Cost-benefit analysis of home blood pressure monitoring in hypertension diagnosis and treatment: an insurer perspective. (United States)

    Arrieta, Alejandro; Woods, John R; Qiao, Nan; Jay, Stephen J


    Home blood pressure (BP) monitoring has been shown to be more effective than clinic BP monitoring for diagnosing and treating hypertension. However, reimbursement of home BP monitoring is uncommon in the United States because of a lack of evidence that it is cost beneficial for insurers. We develop a decision-analytic model, which we use to conduct a cost-benefit analysis from the perspective of the insurer. Model inputs are derived from the 2008 to 2011 claims data of a private health insurer in the United States, from 2009 to 2010 National Health and the Nutrition Examination Survey data, and from published meta-analyses. The model simulates the transitions among health states from initial physician visit to hypertension diagnosis, to treatment, to hypertension-related cardiovascular diseases, and patient death or resignation from the plan. We use the model to estimate cost-benefit ratios and both short- and long-run return on investment for home BP monitoring compared with clinic BP monitoring. Our results suggest that reimbursement of home BP monitoring is cost beneficial from an insurer's perspective for diagnosing and treating hypertension. Depending on the insurance plan and age group categories considered, estimated net savings associated with the use of home BP monitoring range from $33 to $166 per member in the first year and from $415 to $1364 in the long run (10 years). Return on investment ranges from $0.85 to $3.75 per dollar invested in the first year and from $7.50 to $19.34 per dollar invested in the long run.

  12. Flue gas on-line monitoring techniques of continuous emission monitoring system.%烟气排放连续监测系统的烟气参数在线监测技术

    Institute of Scientific and Technical Information of China (English)

    朱卫东; 朱建平; 徐淮明; 范黎峰; 祖亮


    The flue gas monitoring techniques of continuous emission monitoring system are introduced briefly,including flue gas flow rate measurement, flue gas water content measurement and flue gas oxygen content measurement. The applications of the data obtained from flue gas monitoring and the future development of flue gas monitoring techniques are discussed.%简要介绍了烟气排放连续监测系统的烟气参数监测项目及技术要求,包括烟气流速、烟气水分含量、烟气含氧量在线监测技术.对烟气参数在线监测的应用与发展进行了探讨.

  13. Ambulatory blood pressure monitoring for the early identification of hypertension in pregnancy. (United States)

    Ayala, Diana E; Hermida, Ramón C


    Gestational hypertension and preeclampsia are major contributors to perinatal morbidity and mortality. The diagnosis of gestational hypertension still relies on conventional clinic blood pressure (BP) measurements and thresholds of ≥140/90 mm Hg for systolic (SBP)/diastolic (DBP) BP. However, the correlation between BP level and target organ damage, cardiovascular disease risk, and long-term prognosis is greater for ambulatory BP monitoring (ABPM) than clinic BP measurement. Accordingly, ABPM has been suggested as the logical approach to overcoming the low sensitivity and specificity of clinic BP measurements in pregnancy. With the use of ABPM, differing predictable BP patterns throughout gestation have been identified for clinically healthy and hypertensive pregnant women. In normotensive pregnancies, BP steadily decreases up to the middle of gestation and then increases up to the day of delivery. In contrast, women who develop gestational hypertension or preeclampsia show stable BP during the first half of pregnancy and a continuous linear BP increase thereafter until delivery. Epidemiologic studies have also consistently reported sex differences in the 24-h patterns of ambulatory BP and heart rate. Typically, men exhibit a lower heart rate and higher BP than women, the differences being larger for SBP than DBP. Additionally, as early as in the first trimester of gestation, statistically significant increased 24-h SBP and DBP means characterize women complicated with gestational hypertension or preeclampsia compared with women with uncomplicated pregnancies. However, the normally lower BP in nongravid women as compared with men, additional decrease in BP during the second trimester of gestation in normotensive but not in hypertensive pregnant women, and significant differences in the 24-h BP pattern between healthy and complicated pregnancies at all gestational ages have not been taken into consideration when establishing reference BP thresholds for the

  14. Wireless Implementation for Monitoring the Bio-Signal Shape of Blood Vessels

    Directory of Open Access Journals (Sweden)

    Cordova-Fraga Teodoro


    Full Text Available The application of telemetry systems to monitor and send physiological functions raises a number of challenges in project development of modules that can enter the body with minimal intrusion, managing and amplifying the sensitive signals generated by the body, and transmitting them to an external system for data reading. Such devices can be used to monitor and manage the signals from patients and obtain accurate readings in noisy electrical environments (such as operating rooms. The following paper shows an application of wireless communication systems applied to medical measurement and monitoring via Bluetooth.

  15. Full-field speckle correlation technique as applied to blood flow monitoring (United States)

    Vilensky, M. A.; Agafonov, D. N.; Timoshina, P. A.; Shipovskaya, O. V.; Zimnyakov, D. A.; Tuchin, V. V.; Novikov, P. A.


    The results of experimental study of monitoring the microcirculation in tissue superficial layers of the internal organs at gastro-duodenal hemorrhage with the use of laser speckles contrast analysis technique are presented. The microcirculation monitoring was provided in the course of the laparotomy of rat abdominal cavity in the real time. Microscopic hemodynamics was analyzed for small intestine and stomach under different conditions (normal state, provoked ischemia, administration of vasodilative agents such as papaverine, lidocaine). The prospects and problems of internal monitoring of micro-vascular flow in clinical conditions are discussed.

  16. Formation and migration of Natural Gases: gas composition and isotopes as monitors between source, reservoir and seep (United States)

    Schoell, M.; Etiope, G.


    Natural gases form in tight source rocks at temperatures between 120ºC up to 200ºC over a time of 40 to 50my depending on the heating rate of the gas kitchen. Inferring from pyrolysis experiments, gases after primary migration, a pressure driven process, are rich in C2+ hydrocarbons (C2 to C5). This is consistent with gas compositions of oil-associated gases such as in the Bakken Shale which occur in immediate vicinity of the source with little migration distances. However, migration of gases along porous rocks over long distances (up to 200km in the case of the Troll field offshore Norway) changes the gas composition drastically as C2+ hydrocarbons tend to be retained/sequestered during migration of gas as case histories from Virginia and the North Sea will demonstrate. Similar "molecular fractionation" is observed between reservoirs and surface seeps. In contrast to gas composition, stable isotopes in gases are, in general, not affected by the migration process suggesting that gas migration is a steady state process. Changes in isotopic composition, from source to reservoir to surface seeps, is often the result of mixing of gases of different origins. Examples from various gas provinces will support this notion. Natural gas basins provide little opportunity of tracking and identifying gas phase separation. Future research on experimental phase separation and monitoring of gas composition and gas ratio changes e.g. various C2+ compound ratios over C1 or isomer ratios such as iso/n ratios in butane and pentane may be an avenue to develop tracers for phase separation that could possibly be applied to natural systems of retrograde natural condensate fields.

  17. The effects of hypotension on differences between the results of simultaneous venous and arterial blood gas analysis

    Directory of Open Access Journals (Sweden)

    Farhad Shirani


    Full Text Available Background: Analysis of venous blood gas (VBG can represent arterial blood gas (ABG analysis in patients with various diseases. The effects of hypotension on differences between the results of simultaneous venous and arterial blood gas analyses were reviewed. Methods: This observational, cross-sectional study was conducted from March to October 2010 in emergency depart-ments of two university hospitals in Tehran (Iran on consecutive adult patients for whom ABG had been indicated for diagnosis/treatment. Arterial and peripheral venous bloods were simultaneously sampled with blood pressure measure-ment. The VBG-ABG amount of difference regarding pH, HCO 3 , PCO 2 , PO 2 , SO 2 , and Base Excess (BE was com-pared between those with and without hypotension. Results: During the study, 192 patients (51.6 ± 23.6 years, 67.7% males were entered into the hypotension (n = 78 and normotensive groups (n = 114. The average VBG-ABG amount of difference (95% limits of agreement in the hypotension versus normotensive group were -0.030 (-0.09 to 0.03 vs. -0.016 (-0.1 to 0.068 for pH (p = 0.01, 1.79 (-1.91 to 5.49 vs. 1.32 (-1.94 to 4.58 mEq/L for HCO 3 (p = 0.032, 2.69 (-20.43 to 25.81 vs. 2.03 (-7.75 to 11.81 mmHg for PCO 2 (p = 0.295, -35.97 (-130.17 to 58.23 vs. -32.65 (-104.79 to 39.49 mmHg for PO 2 (p = 0.293, -18.58 (-14.66 to 51.82 vs. -9.06 (-31.28 to 13.16 percent (p < 0.001 for SO 2 , and 0.25 (-3.73 to 4.23 vs. 0.79 (-2.51 to 4.09 for BE (p = 0.036. Conclusions: Hypotensive status is associated with an increase in the amount of difference between VBG and ABG analysis regarding pH, HCO 3 , and BE, though the amount of increase does not seem to be clinically important. Studying the precise effects of replacing ABG with VBG on the clinical decision-making and the following outcomes is worth-while.

  18. Ambulatory blood pressure monitoring after 1 year on valsartan or amlodipine-based treatment: a VALUE substudy

    DEFF Research Database (Denmark)

    Pedersen, Ole Lederballe; Mancia, Giuseppe; Pickering, Thomas


    OBJECTIVE: The ambulatory blood pressure (ABP) monitoring substudy of the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was carried out in a subset of patients from USA, Italy and Denmark. ABP was measured after 1 year in the trial, with the aim of evaluating comparability...... of ABP levels on valsartan (VAL) and amlodipine (AML)-based regimens. METHODS: ABP was measured every 20 min during a 25-h period after morning administration of medicine; 659 patients were available for intention-to-treat analysis. RESULTS: Office blood pressure (BP) differences were smaller than...... of combined cardiovascular endpoints--superior to the relationship to office BP. CONCLUSIONS: In these elderly high-risk patients, diastolic ABP levels tended to be less predictive than systolic, and daytime less predictive than night-time for all cardiovascular endpoints. The findings underline...

  19. A mobile monitoring system of blood pressure for underserved in China by information and communication technology service. (United States)

    Jiang, Jiehui; Yan, Zhuangzhi; Kandachar, Prabhu; Freudenthal, Adinda


    High blood pressure (BP, hypertension) is a leading chronic condition in China and has become the main risk factor for many high-risk diseases, such as heart attacks. However, the platform for chronic disease measurement and management is still lacking, especially for underserved Chinese. To achieve the early diagnosis of hypertension, one BP monitoring system has been designed. The proposed design consists of three main parts: user domain, server domain, and channel domain. All three units and their materialization, validation tests on reliability, and usability are described in this paper, and the conclusion is that the current design concept is feasible and the system can be developed toward sufficient reliability and affordability with further optimization. This idea might also be extended into one platform for other physiological signals, such as blood sugar and ECG.

  20. Using blood plasma for monitoring organochlorine contaminants in juvenile white sturgeon, Acipenser transmontanus, from the lower Columbia River. (United States)

    Gundersen, D T; Webb, M A H; Fink, A K; Kushner, L R; Feist, G W; Fitzpatrick, M S; Foster, E P; Schreck, C B


    Organochlorine (OC) pesticide concentrations in blood plasma samples from 88 juvenile white sturgeon collected from the lower Columbia River were measured and compared to plasma sex steroid and OC tissue levels previously measured in corresponding fish. Significant squared correlation coefficients between summation operator DDT concentrations in sturgeon plasma and gonads and livers were 0.37 and 0.32, respectively. Significant negative correlations between plasma testosterone concentration and plasma Sigma DDT concentration in male fish (r(2)=0.26), plasma 17beta estradiol concentration and plasma Sigma DDT concentration in female fish (r(2)=0.38) and condition factor and plasma Sigma DDT concentration in all fish were found (r(2)=0.17). These results suggest that blood plasma may be a suitable nondestructive method for monitoring adult sturgeon population for persistent OC contaminants.

  1. Gas Monitoring System Based on ZigBee Pro and a New Method for Safety Grade Evaluation

    Directory of Open Access Journals (Sweden)

    Shutao Wang


    Full Text Available Aiming at the mine safety problem, this paper proposes a gas concentration monitoring system design scheme based on ZigBee Pro. The scheme designs a set of ZigBee Pro wireless network combined software with hardware based on KGS-20 gas sensor and CC2530 chip as the controller core. According to the fuzzy reasoning technology and multi-factors information fusion technology, a new method for the gas safety grade evaluation is put forward and achieves a high-precision prediction for gas safety grade. The system with the merits of security, anti-interference, high sensitivity, low power consumption, high life expectancy and easy application, has a huge advantage in practical applications.

  2. Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis.

    Directory of Open Access Journals (Sweden)

    Pieter W Smit

    Full Text Available BACKGROUND: Dried blood spots (DBS have been used as alternative specimens to plasma to increase access to HIV viral load (VL monitoring and early infant diagnosis (EID in remote settings. We systematically reviewed evidence on the performance of DBS compared to plasma for VL monitoring and EID. METHODS AND FINDINGS: Thirteen peer reviewed HIV VL publications and five HIV EID papers were included. Depending on the technology and the viral load distribution in the study population, the percentage of DBS samples that are within 0.5 log of VL in plasma ranged from 52-100%. Because the input sample volume is much smaller in a blood spot, there is a risk of false negatives with DBS. Sensitivity of DBS VL was found to be 78-100% compared to plasma at VL below 1000 copies/ml, but this increased to 100% at a threshold of 5000 copies/ml. Unlike a plasma VL test which measures only cell free HIV RNA, a DBS VL also measures proviral DNA as well as cell-associated RNA, potentially leading to false positive results when using DBS. The systematic review showed that specificity was close to 100% at DBS VL above 5000 copies/ml, and this threshold would be the most reliable for predicting true virologic failure using DBS. For early infant diagnosis, DBS has a sensitivity of 100% compared to fresh whole blood or plasma in all studies. CONCLUSIONS: Although limited data are available for EID, DBS offer a highly sensitive and specific sampling strategy to make viral load monitoring and early infant diagnosis more accessible in remote settings. A standardized approach for sampling, storing, and processing DBS samples would be essential to allow successful implementation. TRIAL REGISTRATION: PROSPERO Registration #: CRD42013003621.

  3. Systematic Review of the Use of Dried Blood Spots for Monitoring HIV Viral Load and for Early Infant Diagnosis (United States)

    Smit, Pieter W.; Sollis, Kimberly A.; Fiscus, Susan; Ford, Nathan; Vitoria, Marco; Essajee, Shaffiq; Barnett, David; Cheng, Ben; Crowe, Suzanne M.; Denny, Thomas; Landay, Alan; Stevens, Wendy; Habiyambere, Vincent; Perriens, Joseph H.; Peeling, Rosanna W.


    Background Dried blood spots (DBS) have been used as alternative specimens to plasma to increase access to HIV viral load (VL) monitoring and early infant diagnosis (EID) in remote settings. We systematically reviewed evidence on the performance of DBS compared to plasma for VL monitoring and EID. Methods and Findings Thirteen peer reviewed HIV VL publications and five HIV EID papers were included. Depending on the technology and the viral load distribution in the study population, the percentage of DBS samples that are within 0.5 log of VL in plasma ranged from 52–100%. Because the input sample volume is much smaller in a blood spot, there is a risk of false negatives with DBS. Sensitivity of DBS VL was found to be 78–100% compared to plasma at VL below 1000 copies/ml, but this increased to 100% at a threshold of 5000 copies/ml. Unlike a plasma VL test which measures only cell free HIV RNA, a DBS VL also measures proviral DNA as well as cell-associated RNA, potentially leading to false positive results when using DBS. The systematic review showed that specificity was close to 100% at DBS VL above 5000 copies/ml, and this threshold would be the most reliable for predicting true virologic failure using DBS. For early infant diagnosis, DBS has a sensitivity of 100% compared to fresh whole blood or plasma in all studies. Conclusions Although limited data are available for EID, DBS offer a highly sensitive and specific sampling strategy to make viral load monitoring and early infant diagnosis more accessible in remote settings. A standardized approach for sampling, storing, and processing DBS samples would be essential to allow successful implementation. Trial Registration PROSPERO Registration #: CRD42013003621. PMID:24603442

  4. A Greenhouse-Gas Information System: Monitoring and Validating Emissions Reporting and Mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Jonietz, Karl K. [Los Alamos National Laboratory; Dimotakis, Paul E. [JPL/CAL Tech; Rotman, Douglas A. [Lawrence Livermore National Laboratory; Walker, Bruce C. [Sandia National Laboratory


    This study and report focus on attributes of a greenhouse-gas information system (GHGIS) needed to support MRV&V needs. These needs set the function of such a system apart from scientific/research monitoring of GHGs and carbon-cycle systems, and include (not exclusively): the need for a GHGIS that is operational, as required for decision-support; the need for a system that meets specifications derived from imposed requirements; the need for rigorous calibration, verification, and validation (CV&V) standards, processes, and records for all measurement and modeling/data-inversion data; the need to develop and adopt an uncertainty-quantification (UQ) regimen for all measurement and modeling data; and the requirement that GHGIS products can be subjected to third-party questioning and scientific scrutiny. This report examines and assesses presently available capabilities that could contribute to a future GHGIS. These capabilities include sensors and measurement technologies; data analysis and data uncertainty quantification (UQ) practices and methods; and model-based data-inversion practices, methods, and their associated UQ. The report further examines the need for traceable calibration, verification, and validation processes and attached metadata; differences between present science-/research-oriented needs and those that would be required for an operational GHGIS; the development, operation, and maintenance of a GHGIS missions-operations center (GMOC); and the complex systems engineering and integration that would be required to develop, operate, and evolve a future GHGIS.

  5. Gas centrifuge enrichment plants inspection frequency and remote monitoring issues for advanced safeguards implementation

    Energy Technology Data Exchange (ETDEWEB)

    Boyer, Brian David [Los Alamos National Laboratory; Erpenbeck, Heather H [Los Alamos National Laboratory; Miller, Karen A [Los Alamos National Laboratory; Ianakiev, Kiril D [Los Alamos National Laboratory; Reimold, Benjamin A [Los Alamos National Laboratory; Ward, Steven L [Los Alamos National Laboratory; Howell, John [GLASGOW UNIV.


    Current safeguards approaches used by the IAEA at gas centrifuge enrichment plants (GCEPs) need enhancement in order to verify declared low enriched uranium (LEU) production, detect undeclared LEU production and detect high enriched uranium (BEU) production with adequate probability using non destructive assay (NDA) techniques. At present inspectors use attended systems, systems needing the presence of an inspector for operation, during inspections to verify the mass and {sup 235}U enrichment of declared cylinders of uranium hexafluoride that are used in the process of enrichment at GCEPs. This paper contains an analysis of how possible improvements in unattended and attended NDA systems including process monitoring and possible on-site destructive analysis (DA) of samples could reduce the uncertainty of the inspector's measurements providing more effective and efficient IAEA GCEPs safeguards. We have also studied a few advanced safeguards systems that could be assembled for unattended operation and the level of performance needed from these systems to provide more effective safeguards. The analysis also considers how short notice random inspections, unannounced inspections (UIs), and the concept of information-driven inspections can affect probability of detection of the diversion of nuclear material when coupled to new GCEPs safeguards regimes augmented with unattended systems. We also explore the effects of system failures and operator tampering on meeting safeguards goals for quantity and timeliness and the measures needed to recover from such failures and anomalies.

  6. A versatile integrating sphere based photoacoustic sensor for trace gas monitoring

    CERN Document Server

    Lassen, Mikael; Brusch, Anders; Petersen, Jan C


    A compact versatile photoacoustic (PA) sensor for trace gas detection is reported. The sensor is based on an integrating sphere as the PA absorption cell with an organ pipe tube attached to increase the sensitivity of the PA sensor. The versatility and enhancement of the sensitivity of the PA signal is investigated by monitoring specific ro-vibrational lines of CO2 in the 2 mm wavelength region and of NO2 in the 405 nm region. The measured enhancement factor of the PA signal exceeds 1200, which is due to the acoustic resonance of the tube and the absorption enhancement of the integrating sphere relatively to a non-resonant single pass cell. It is observed that the background absorption signals are highly attenuated due to the thermal conduction and diffusion effects in the polytetrafluoroethylene cell walls. This demonstrates that careful choice of cell wall materials can be highly beneficial to the sensitivity of the PA sensor. These properties makes the sensor suitable for various practical sensor applicati...

  7. Microprocessor-based near real-time bedside blood chemistry monitor. (United States)

    Wong, D K; Jordan, W S


    A microprocessor-based instrument which integrates the function of a volumetric infusion pump with a blood chemistry analyzer has been developed. Presently, the instrument is capable of measuring Na+, K+, Ca++ and pH within approximately 40 sec at a frequency of up to every 2 min. The system is set up as an intravenous (IV) infusion pump with the addition of an array of disposable sensors placed at the distal end of the IV set. An isotonic IV solution is used to keep the site patent while also serving as a calibrant for the sensors. The instrument first calibrates the sensors, then withdraws approximately 0.6 ml of blood to come in contact with the sensors. Within approximately 15 sec, it displays the results, flushes the blood back into the patient and resumes normal infusion. There is no blood loss to the patient and no need to handle blood. The system was first validated with known aqueous controls and then used on-line in a variety of animal studies where dynamic fluctuation of electrolytes and pH occurred. Excellent correlation was found with off-line samples tested on conventional STAT analyzers. Some preliminary patient data is also presented.

  8. A Cysteine-Specific Fluorescent Switch for Monitoring Oxidative Stress and Quantification of Aminoacylase-1 in Blood Serum. (United States)

    A, Anila H; Ali, Firoj; Kushwaha, Shilpi; Taye, Nandaraj; Chattopadhyay, Samit; Das, Amitava


    Reagents that allows detection and monitoring of crucial biomarkers with luminescence ON response have significance in clinical diagnostics. A new coumarin derivative is reported here, which could be used for specific and efficient chemodosimetric detection of cysteine, an important biomarker. The probe is successfully used for studying the biochemical transformation of N-acetylcysteine, a commonly prescribed Cys supplement drug to Cys by aminoacylase-1 (ACY-1), an important and endogenous mammalian enzyme. The possibility of using this reagent for quantification of ACY-1 in blood serum samples is also explored. Nontoxic nature and cell membrane permeability are key features of this probe and are ideally suited for imaging intracellular Cys in normal and cancerous cell lines. Our studies have also revealed that this reagent could be utilized as a redox switch to monitor the hydrogen-peroxide-induced oxidative stress in living SW480 cell lines. Peroxide-mediated cysteine oxidation has a special significance for understanding the cellular-signaling events.

  9. Laser speckle contrast imaging for monitoring changes in microvascular blood flow

    DEFF Research Database (Denmark)

    Ambrus, Rikard; Strandby, Rune B.; Svendsen, Lars Bo;


    BACKGROUND/AIMS: Microvascular blood flow is essential for healing and predicts surgical outcome. The aim of the current study was to investigate the relation between fluxes measured with the laser speckle contrast imaging (LSCI) technique and changes in absolute blood flow. In addition, we studied...... the reproducibility of the LSCI technique when assessing the intra-abdominal microcirculation of the pig. METHODS: During trial 1, a fish gill arch was mechanically perfused with heparinized fish blood under controlled stepwise-altered flow rates alongside mechanically induced movement artefacts. The microcirculation...... = 6.0, 3.2, and 6.4%, respectively). CONCLUSION: Due to the non-contact and real-time assessment over large areas, LSCI is a promising technique for the intraoperative assessment of intra-abdominal microcirculation. A linear correlation between flux and volumetric flow was found, in accordance...

  10. A Portable Gas Sensor System for Environmental Monitoring and Malodours Control: Data Assessment of an Experimental Campaign (United States)

    Penza, Michele; Suriano, Domenico; Cassano, Gennaro; Rossi, Riccardo; Alvisi, Marco; Pfister, Valerio; Trizio, Livia; Brattoli, Magda; Amodio, Martino; De Gennaro, Gianluigi


    A portable sensor-system based on solid-state gas sensors has been designed and implemented as proof-of-concept for environmental air-monitoring applications, malodours olfactometric control and landfill gas monitoring. Commercial gas sensors and nanotechnology sensors are arranged in a configuration of array for multisensing and multiparameter devices. Wireless sensors at low-cost are integrated to implement a portable and mobile node, that can be used as early-detection system in a distributed sensor network. Real-time and continuous monitoring of hazardous air-contaminants (NO2, CO, PAH, BTEX, etc.) has been performed in field measurements by comparison of chemical analyzers from environmental protection governmental agency (ARPA-Puglia). In addition, experimental campaigns of the integrated portable sensor-system have been realized for assessment of malodours emitted from an urban waste site. The results demonstrate that the sensor-system has a potential capacity for real-time measurements of air-pollutants, malodours from waste site, and control of landfill gas.

  11. Casual and ambulatory blood pressure monitoring in children with renal scarring

    Directory of Open Access Journals (Sweden)

    Miloševski Gordana


    Full Text Available INTRODUCTION Renal scarring is the most common cause of arterial hypertension in children. High blood pressure (BP and microalbuminuria contribute to the progression of chronic renal disease. OBJECTIVE The aims of the study were: to assess BP in children with renal scarring by continuous ambulatory blood pressure measurement (ABPM in comparison to the casual method (CBP, and to determine the correlation between ambulatory blood pressure (ABP and/or casual blood pressure (CBP values and proteinuria in children with renal scarring. METHOD This forward-looking study comprised thirty-five children (26 girls and 9 boys, aged between 3-13 years, 10.4±3.9, X+SD. Blood pressure was measured using the casual method (CBP with a mercury manometer; BP was measured three times and the average was taken as a referent value. ABPM was performed using the oscillometric method with the Space Labs device, model 90207. RESULTS 45.71% of patients were classified as hypertensive by ABPM, while only 22.6% of CBP measurements were above the 95th percentile (p<0.01. "White coat hypertension" was present in 40% of the patients. Non-dipping BP alteration was detected in 37.14% of the patients. CONCLUSION Nocturnal systolic hypertension (systolic non-dipping alteration is very frequent in children with renal scarring. Nocturnal diastolic blood pressure, detectable only via ABPM, is positively correlated with proteinuria and may be an initial sign of the progression of renal scarring. ABPM is more sensitive than CBP in the evaluation of BP in children with renal scarring.

  12. Moderator's view: Ambulatory blood pressure monitoring and home blood pressure for the prognosis, diagnosis and treatment of hypertension in dialysis patients. (United States)

    Zoccali, Carmine; Tripepi, Rocco; Torino, Claudia; Tripepi, Giovanni; Mallamaci, Francesca


    Major health agencies now recommend the systematic application of ambulatory blood pressure monitoring (ABPM) for the diagnosis of hypertension. Given the exceedingly high prevalence of nocturnal hypertension, masked and white coat hypertension and the overt inadequacy of peridialysis (pre-, intra- and post-dialysis) BP measurements, more extensive application of ABPM for the diagnosis of hypertension in dialysis patients would appear logical. In a recent survey performed in NDT Educational, organizational problems and/or cognitive resistance emerged as important factors hindering more extensive application of ABPM and home BP by nephrologists. External validation of observations made in landmark studies in a single institution about hypertension subcategorization by ABPM is urgently needed. Furthermore, apparent cognitive resistance by nephrologists may be justified by the fact that these techniques have been insufficiently tested in the dialysis population for applicability in everyday clinical practice, tolerability, organizational impact and cost-effectiveness. We should be more resolute in abandoning peridialysis measurements for diagnosing and treating hypertension in haemodialysis patients. Home BP is a formidable educational instrument for patient empowerment and self-care, and evidence exists that this technique is superior to peridialysis values to better hypertension control as defined on the basis of ABPM. We should strive to promote more extensive application of home BP monitoring to diagnose and manage hypertension in haemodialysis patients. ABPM with novel, user friendly and better tolerated techniques is to be awaited in the near future.

  13. Effects of education on self-monitoring of blood pressure based on BASNEF model in hypertensive patients

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Baghianimoghadam


    Full Text Available Background: Hypertension is one of the most important health problems. Self-monitoring may be an effective method for controlling this disease. The aim of this study is to determine the effectiveness of education on blood pressure self-monitoring in patients with hypertension based on BASNEF model. Methods: In this clinical trial, 150 outpatients with hypertension were randomly selected from those referred to private clinics in Yazd, Iran, during 2008. They were divided in two groups. The data were collected by a validated and reliable questionnaire. The implementing educational program was continued for 2 months and the pre-test and post-test had an interval of 2-months. BASNEF model was applied to explain the motivation of a behavior. Descriptive analysis, correlation test and also regression analysis were used to analyze data. Results: The respondents acquired 17.72% of total score for self-monitoring behavior, 47.03% of attitude, 12.37% of subjective norms, 33.46% of intention and 50.95% of enabling factors. After intervention, there were significant increases in self-monitoring behavior (173.31%, attitude (62.60%, subjective norms (54.70%, intention (129.93% and enabling factors (46.62% in the intervention group. There was no significant difference between the constructs of BASNEF model in the control group after intervention compared to the baseline values (p > 0.05. Conclusions: The results of this study showed that the level of self-monitoring behavior in the patients was low. Educational programs are helpful and necessary to improve self-monitoring behavior in patients with hypertension.

  14. The effect of intra-operative transcutaneous electrical nerve stimulation on posterior neck pain following thyroidectomy. (United States)

    Park, C; Choi, J B; Lee, Y-S; Chang, H-S; Shin, C S; Kim, S; Han, D W


    Posterior neck pain following thyroidectomy is common because full neck extension is required during the procedure. We evaluated the effect of intra-operative transcutaneous electrical nerve stimulation on postoperative neck pain in patients undergoing total thyroidectomy under general anaesthesia. One hundred patients were randomly assigned to one of two groups; 50 patients received transcutaneous electrical nerve stimulation applied to the trapezius muscle and 50 patients acted as controls. Postoperative posterior neck pain and anterior wound pain were evaluated using an 11-point numerical rating scale at 30 min, 6 h, 24 h and 48 h following surgery. The numerical rating scale for posterior neck pain was significantly lower in the transcutaneous electrical nerve stimulation group compared with the control group at all time points (p pain at any time point. No adverse effects related to transcutaneous electrical nerve stimulation were observed. We conclude that intra-operative transcutaneous electrical nerve stimulation applied to the trapezius muscle reduced posterior neck pain following thyroidectomy.

  15. Compact Multi-Gas Monitor for Life Support Systems Control in Space: Evaluation Under Realistic Environmental Conditions (United States)

    Alonso, Jesus Delgado; Phillips, Straun; Chullen, Cinda; Mendoza, Edgar


    Advanced space life support systems require lightweight, low-power, durable sensors for monitoring critical gas components. A luminescence-based optical flow-through cell to monitor carbon dioxide, oxygen, and humidity has been developed and was demonstrated using bench-top instrumentation under environmental conditions relevant to portable life support systems, including initially pure oxygen atmosphere, temperature range from 50 F to 150 F, and humidity from dry to 100% RH and under conditions of water condensation. This paper presents the most recent progress in the development of this sensor technology. Trace gas contaminants in a space suit, originating from hardware and material off-gassing and crew member metabolism, are from many chemical families. The result is a gas mix much more complex than the pure oxygen fed into the space suit, and this complexity may interfere with gas sensor readings. This paper presents an evaluation of optical sensor performance when exposed to the most significant trace gases reported to be found in space suits. A study of the calibration stability of the sensors is also presented. For that purpose, a profile of temperature, pressure, humidity, and gas composition for the duration of an EVA has been defined, and the performance of sensors operated repeatedly under those conditions has been studied. Finally, this paper presents the first compact readout unit for these optical sensors, designed for the volume, power, and weight restrictions of a PLSS.

  16. Comparative evaluation of online oil and gas monitor; Avaliacao de monitores de teor de oleo e graxa em linha

    Energy Technology Data Exchange (ETDEWEB)

    Louvisse, Ana Maria Travalloni; Pereira Junior, Oswaldo de Aquino; Jesus, Rafael Ferreira de; Santos, Lino Antonio Duarte dos; Lopes, Humberto Eustaquio [PETROBRAS, Rio de Janeiro, RJ (Brazil)


    Petroleum is predominantly recovered in form of water in oil emulsions, which are stabilised by petroleum resins and asphaltenes, the colloidal disperse components of crude oil. The water phase, separated during the production process, consists of a dilute oil in water emulsion, commonly called produced water.There are a wide variety of methods for determination of oil in produced water that are commercially based on a number of technique. On line continuously monitoring shall be particularly useful in providing information to assist in optimising the separation process and also to attend the environmental legislation for discharge the produced water. There are a wide variety of on line oil in water monitors that are commercially available based on a number of technique. In this paper, a comparative evaluation was made between some methods of on line oil in water detecting. These are light scattering and ultraviolet fluorescence technique. A brief description of the optical methods will be discussed and some of associated problems and limitation are pointed. The work was done in a specific experimental set up that allows the simultaneous pumping of crude oil and water through a calibrated restriction in a pipe has been used. A permanent pressure drop induced by the restriction leads to the dispersion of the oil droplets in the water phase. The monitors based on light scattering technique tested show good agreement between monitor reading and the oil dispersion used. Otherwise for ultraviolet fluorescence based monitors show a significant effect of the variation of oil type. (author)

  17. Theranastic USPIO-loaded microbubbles for mediating and monitoring blood-brain barrier permeation

    NARCIS (Netherlands)

    Lammers, Twan; Koczera, Patrick; Fokong, Stanley; Gremse, Felix; Ehling, Josef; Vogt, Michael; Pich, Andrij; Storm, Gert; Zandvoort, van Marc; Kiessling, Fabian


    Efficient and safe drug delivery across the blood-brain barrier (BBB) remains one of the major challenges of biomedical and (nano-) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)-based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanop

  18. Theranostic USPIO-loaded microbubbles for mediating and monitoring blood-brain barrier permeation

    NARCIS (Netherlands)

    Lammers, Twan; Koczera, Patrick; Fokong, Stanley; Gremse, Felix; Ehling, Josef; Vogt, Michael; Pich, Andrij; Storm, G; Van Zandvoort, Marc; Kiessling, Fabian


    Efficient and safe drug delivery across the blood-brain barrier (BBB) remains one of the major challenges of biomedical and (nano-) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)-based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanop

  19. Beyond White Blood Cell Monitoring : Screening in the Initial Phase of Clozapine Therapy

    NARCIS (Netherlands)

    Cohen, Dan; Bogers, Jan P. A. M.; van Dijk, Daniel; Bakker, Bert; Schulte, Peter F. J.


    Objective: Clozapine is the preferred option for treatment-resistant schizophrenia. However, since 1975, clozapine has been known to cause agranulocytosis. In the clozapine screening guidelines, white blood cell count is mandatory. In the past 20 years, after its reintroduction, 3 other serious side

  20. Blood Glucose Monitoring as a Teaching Tool for Endocrinology: A New Perspective (United States)

    Moats, Robert K., II


    The education of new allied health professionals and nurses in proper endocrine evaluation and care has become critical in recent years, especially considering the greatly increased prevalence of diabetes in adults and children. The evaluation of blood glucose levels in human volunteers over time is a powerful teaching tool for endocrinology that…

  1. Understanding Challenges and Opportunities of Preventive Blood Pressure Self-Monitoring at Home

    DEFF Research Database (Denmark)

    Grönvall, Erik; Verdezoto, Nervo


    The herein presented study explores socio-technical complexities that may occur when introducing preventive health-measurement technologies in older adults’ daily routines and everyday lives. Using mainly blood pressure measurements in private homes, the study applied qualitative and quantitative...

  2. 家庭血压监测对社区高血压病人血压控制的价值探讨%The Change of Blood Pressure in Patients with Hypertension by Home Blood Pressure Monitoring

    Institute of Scientific and Technical Information of China (English)

    张仁汉; 芦娜; 李洪山; 黄超


    Objective: To observe the change of blood pressure, by means of home blood pressure monitoring in patients with hypertension. Method: 212 patients with hypertension were included to proceed home blood pressure monitoring for three months. The data of ambulatory blood pressure monitoring before and after the home blood pressure monitoring were recorded and analyzed. Result:After regular home blood pressure monitoring for three months, the 24h-systolic blood pressure, day systolic blood pressure, and night systolic blood pressure were depressed (P<0.05), and the day mean blood pressure and 24h mean blood pressure were lowered significantly(P<0.05). Conclusion:By means of regular home blood pressure monitoring, the total level of blood pressure are controlled lower in patients with hypertension. It is beneficial for improvement of controlling rate of hypertension and decreasing of complication.%  目的:观察家庭自测血压对高血压病人血压变化的影响。方法:212例门诊高血压病人经过家庭自测血压培训,进行规定的家庭血压监测,持续3个月,观察监测前后动态血压参数的变化。结果:与监测前相比,监测3个月后24h收缩压、白天收缩压、夜间收缩压均有明显降低(P<0.05);在监测3个月后白天平均压和24h平均压也有明显降低(P<0.05)。结论:通过规律的家庭自测血压,可使患者整体血压水平降低,从而有利于提高高血压的控制率和降低高血压的并发症。

  3. Method of monitoring photoactive organic molecules in-situ during gas-phase deposition of the photoactive organic molecules (United States)

    Forrest, Stephen R.; Vartanian, Garen; Rolin, Cedric


    A method for in-situ monitoring of gas-phase photoactive organic molecules in real time while depositing a film of the photoactive organic molecules on a substrate in a processing chamber for depositing the film includes irradiating the gas-phase photoactive organic molecules in the processing chamber with a radiation from a radiation source in-situ while depositing the film of the one or more organic materials and measuring the intensity of the resulting photoluminescence emission from the organic material. One or more processing parameters associated with the deposition process can be determined from the photoluminescence intensity data in real time providing useful feedback on the deposition process.

  4. The Residual Gas Ionization Profile Monitor in the J-PARC 3-GeV Rapid Cycling Synchrotron (United States)

    Harada, Hiroyuki; Kato, Shinichi

    The residual gas Ionization Profile Monitor (IPM) is developed in the J-PARC 3-GeV RCS. The IPM is a non-destructive beam profile monitor to observe a circulating transverse beam profile in the ring. It is very important to observe the beam profile turn-by-turn in the ring for identification of the beam loss and emittance growth source because beam loss is always issue in increasing the beam power in terms of keeping hands on maintenance. The IPM has been continuously upgraded since 2008. The recent progress of the IPM is reported together with the outline of IPM system.

  5. Transcutaneous electrical nerve stimulation therapy in reduction of orofacial pain

    Directory of Open Access Journals (Sweden)

    Đorđević Igor


    Full Text Available Introduction. Patients with craniomandibular disorders suffer from hypertonic, fatigued and painful masticatory muscles. This condition can lead to limitation of mandibular jaw movements. All of these symptoms and signs are included in myofascial pain dysfunction syndrome. Transcutaneous electrical nerve stimulation (TENS has been used for treatment of these patients. Objective. The aim of this study was to assess the effect of TENS therapy on chronic pain reduction in patients with the muscular dysfunction symptom. Methods. In order to evaluate the effect of TENS therapy before and after the treatment, Craniomandibular Index (Helkimo was used. Pain intensity was measured by VAS. Patients had TENS treatment over two-week period. BURST TENS modality was used. Current intensity was individually adjusted. Results. Two patients did not respond to TENS therapy. Complete pain reduction was recorded in 8 patients, while pain reduction was not significantly different after TENS therapy in 10 patients. Conclusion. TENS therapy was confirmed as therapeutic procedure in orofacial muscle relaxation and pain reduction.

  6. Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. (United States)

    Jacobs, Heidi I L; Riphagen, Joost M; Razat, Chantalle M; Wiese, Svenja; Sack, Alexander T


    Direct vagus nerve stimulation (dVNS) is known to improve mood, epilepsy, and memory. Memory improvements have been observed in Alzheimer's disease patients after long-term stimulation. The potential of transcutaneous vagus nerve stimulation (tVNS), a noninvasive alternative to dVNS, to alter memory performance remains unknown. We aimed to investigate the effect of a single-session tVNS on associative memory performance in healthy older individuals. To investigate this, we performed a single-blind sham-controlled randomized crossover pilot study in healthy older individuals (n = 30, 50% female). During the stimulation or sham condition, participants performed an associative face-name memory task. tVNS enhanced the number of hits of the memory task, compared with the sham condition. This effect was specific to the experimental task. Participants reported few side effects. We conclude that tVNS is a promising neuromodulatory technique to improve associative memory performance in older individuals, even after a single session. More research is necessary to investigate its underlying neural mechanisms, the impact of varying stimulation parameters, and its applicability in patients with cognitive decline.

  7. Successful Treatment of Dercum's Disease by Transcutaneous Electrical Stimulation (United States)

    Martinenghi, Sabina; Caretto, Amelia; Losio, Claudio; Scavini, Marina; Bosi, Emanuele


    Abstract Dercum's disease is a rare condition of painful subcutaneous growth of adipose tissue. Etiology is unknown and pain is difficult to control. We report the case of a 57-year-old man with generalized diffuse Dercum's disease, who improved after the treatment with transcutaneous frequency rhythmic electrical modulation system (FREMS). Treatment consisted in 4 cycles of 30 minutes FREMS sessions over a 6-month period. Measures of efficacy included pain assessment (visual analogue scale, VAS), adipose tissue thickness by magnetic resonance imaging, total body composition and regional fat mass by dual-energy X-ray absorptiometry, physical disability (Barthel index), and health status (Short Form-36 questionnaire). After FREMS treatment the patient's clinical conditions significantly improved, with reduction of pain on the VAS scale from 64 to 17 points, improvement of daily life abilities (the Barthel index increased from 12 to 18) and amelioration of health status (higher scores than baseline in all Short Form-36 domains). Furthermore, we documented a 12 mm reduction in subcutaneous adipose tissue thickness at the abdominal wall and a 7040 g decrease in total body fat mass. FREMS therapy proved to be effective and safe in the treatment of this rare and disabling condition. PMID:26091459

  8. Improvement of physical performance by transcutaneous nerve stimulation in athletes. (United States)

    Kaada, B


    The present pilot study tested the exercise response to transcutaneous nerve stimulation (TNS) of 21 volunteers, who were well-trained competitive athletes. In 62 experiments (n) they received low-frequency TNS (2 Hz) for 30-45 min prior to either a road or track race, swimming race, bicycle ergometer exercise, isometric muscular endurance test, or dynamometer hand grip test. Improvement in performance compared with a corresponding number of control tests, without TNS or with placebo stimulation in the same subjects, was almost regularly observed in running, swimming and ergometer cycling, although with great individual variations. The average improvement was 4.3 sec (2.2%) in 1.000 m road racing (n = 9); 2.3 sec (1.8%) in 800 m track racing (n = 5); 0.9 sec (1.4%) in 100 m swimming (n = 12); 1.3 sec (0.8%) in 200 m swimming (n = 6); and 2.5 sec (0.9%) in 400 m swimming (n = 3). In a bicycle ergometer test with stepwise, progressive exercise to muscular fatigue, the maximal capacity was increased by 9% (n = 4). Local isometric muscle endurance of the elbow flexors (n = 7) and hand grip strengths (n = 11) were not significantly altered. Possible mechanisms involved in the response to TNS are discussed.

  9. Time-Series Analysis of Continuously Monitored Blood Glucose: The Impacts of Geographic and Daily Lifestyle Factors

    Directory of Open Access Journals (Sweden)

    Sean T. Doherty


    Full Text Available Type 2 diabetes is known to be associated with environmental, behavioral, and lifestyle factors. However, the actual impacts of these factors on blood glucose (BG variation throughout the day have remained relatively unexplored. Continuous blood glucose monitors combined with human activity tracking technologies afford new opportunities for exploration in a naturalistic setting. Data from a study of 40 patients with diabetes is utilized in this paper, including continuously monitored BG, food/medicine intake, and patient activity/location tracked using global positioning systems over a 4-day period. Standard linear regression and more disaggregated time-series analysis using autoregressive integrated moving average (ARIMA are used to explore patient BG variation throughout the day and over space. The ARIMA models revealed a wide variety of BG correlating factors related to specific activity types, locations (especially those far from home, and travel modes, although the impacts were highly personal. Traditional variables related to food intake and medications were less often significant. Overall, the time-series analysis revealed considerable patient-by-patient variation in the effects of geographic and daily lifestyle factors. We would suggest that maps of BG spatial variation or an interactive messaging system could provide new tools to engage patients and highlight potential risk factors.

  10. The effect of siesta in parameters of cardiac structure and in interpretation of ambulatory arterial blood pressure monitoring

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    Marco A.M. Gomes


    Full Text Available OBJECTIVE: To evaluate the influence of the siesta in ambulatory blood pressure (BP monitoring and in cardiac structure parameters. METHODS: 1940 ambulatory arterial blood pressure monitoring tests were analyzed (Spacelabs 90207, 15/15 minutes from 7:00 to 22:00 hours and 20/20 minutes from 22:01 to 6.59hours and 21% of the records indicated that the person had taken a siesta (263 woman, 52±14 years. The average duration of the siesta was 118±58 minutes. RESULTS: (average ± standard deviation The average of systolic/diastolic pressures during wakefulness, including the napping period, was less than the average for the period not including the siesta (138±16/85±11 vs 139±16/86±11 mmHg, p5%. CONCLUSION: The siesta influenced the heart structure parameters and from a statistical point of view the average of systolic and diastolic pressures and the respective pressure loads of the wakeful period.

  11. Renal Fractional Excretion of Sodium in Relation to Arterial Blood Gas and Spirometric Parameters in Chronic Obstructive Pulmonary Disease

    Directory of Open Access Journals (Sweden)

    Fariba Rezaeetalab


    Full Text Available Introduction: Arterial gas derangement could change urinary sodium excretion in Chronic Obstructive Pulmonary Disease (COPD patients.There are very few and conflicting data in regards to the measurement of fractional excretion of sodium in COPD patients. The main aim of this study was to assess the relationship between renal fractional excretion of sodium(FeNa with arterial blood gas and spirometric parameters in COPD. Materials and Methods: This study was a cross-sectional study performed on 40 consecutive stable COPD outpatients in 2 main general hospitals (Emam Reza, Ghaem in Mashhad/Iran between 2011 and 2012. We investigated the relationship of renal FeNa with arterial blood gas parameters including HCO3, PH, PaCO2 and PaO2, and spirometric parameters. Analysis was done by SPSS v16 with a statistically meaningful p value of less than 0.05. Results: Mean age was 65.97±10.77 SD years and female to male ratio was 0.26. A renal FeNa of less than 1% was presented in 27% patients. There was a significant, positive relationship between renal FeNa and PaO2 (P=0.005, r=0.456. The correlations between PaCO2, HCO3, PH and spirometric parameters were not seen (P>0.05, but there was a significant relationship between Urine Na and PaO2. Outstanding, it seems likely that kidneys of COPD patients are responsible for sodium retaining state particularly in the presence of hypoxemia. Conclusion: This study indicates that in COPD patients, PaO2 but not PaCO2 is related to renal FeNa which shows the probable role of hypoxemia on sodium output in COPD patients. However, some caution is needed for interpretation of the probable role of hypercapnia on sodium retention in COPD.

  12. Evaluation of dried blood spots as sample matrix for gas chromatography/mass spectrometry based metabolomic profiling. (United States)

    Kong, Sing Teang; Lin, Hai-Shu; Ching, Jianhong; Ho, Paul C


    We propose using dried blood spots (DBS) as sample matrix for gas chromatography/mass spectrometry (GC/MS) based metabolomic profiling for the benefits of higher sample stability, more convenient sample acquisition with DBS, higher analyte separation power, and more readily biomarker identification with GC/MS. To establish this proposition, the metabolomic profiles generated from DBS were compared with that obtained from the conventional whole blood and plasma matrixes and also with dried plasma spots (DPS) as another covariate control. Our findings indicated that whole blood produced the most number of detectable markers (866), whereas DPS yielded the least number (614). DBS and plasma matrix, on the other hand, produced the most similar numbers of detectable (695 vs 749) and identifiable markers (137 vs 147, matching with Fiehn library). From the analysis of the DBS and plasma metabolomic profiles, it was concluded that when l-lysine 2, iminodiacetic acid 2, dl-threo-beta-hydroxyaspartic acid, citric acid, or adenosine-5-monophosphate 2 are not involved as markers, DBS could be a suitable substitute for plasma for metabolomic profiling.

  13. The pharmacist and the management of arterial hypertension: the role of blood pressure monitoring and telemonitoring. (United States)

    Omboni, Stefano; Sala, Elisa


    Randomized controlled trials have documented that a team of health care professionals which includes a physician, a nurse and a community pharmacist may improve the benefit and adherence of anti-hypertensive therapy. If such a health care model relies on blood pressure telemonitoring, it can promote a stronger relationship between health care professionals and patients, and further improve BP control of hypertension. The major benefit of this collaborative approach is to center the patient's management in a tailored way, providing comprehensive and preventive care based on health information technologies. In this review, the authors summarize recent clinical studies that evaluate the role of the community pharmacist in BP measurements, and in hypertension screening and control. The authors also describe the advantages of using blood pressure telemonitoring in home and ambulatory settings to evaluate potential alternatives to primary care in hypertension management.

  14. A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy (United States)

    Lee, Hyunjae; Choi, Tae Kyu; Lee, Young Bum; Cho, Hye Rim; Ghaffari, Roozbeh; Wang, Liu; Choi, Hyung Jin; Chung, Taek Dong; Lu, Nanshu; Hyeon, Taeghwan; Choi, Seung Hong; Kim, Dae-Hyeong


    Owing to its high carrier mobility, conductivity, flexibility and optical transparency, graphene is a versatile material in micro- and macroelectronics. However, the low density of electrochemically active defects in graphene synthesized by chemical vapour deposition limits its application in biosensing. Here, we show that graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy. The stretchable device features a serpentine bilayer of gold mesh and gold-doped graphene that forms an efficient electrochemical interface for the stable transfer of electrical signals. The patch consists of a heater, temperature, humidity, glucose and pH sensors and polymeric microneedles that can be thermally activated to deliver drugs transcutaneously. We show that the patch can be thermally actuated to deliver Metformin and reduce blood glucose levels in diabetic mice.

  15. Rheoencephalography (REG) as a Non-Invasive Monitoring Alternative for the Assessment of Brain Blood Flow (United States)


    bioimpedance (rheoencephalography - REG) measurement as a non-invasive, continuous method for assessing the status of cerebral blood flow (CBF) in combat...Dunster KR, Colditz PB, Ward LC. Noninvasive measurement of cerebral bioimpedance for detection of cerebral edema in the neonatal piglet. Brain Res...REG measurements and DC impedance (Ro) were recorded simultaneously on a portable IBM compatible computer using CODAS (DATAQ, Inc., Akron, OH) data

  16. Ambulatory instrument for monitoring indirect beat-to-beat blood pressure in superficial temporal artery using volume-compensation method. (United States)

    Tanaka, S; Yamakoshi, K


    A portable instrument, based on a volume-compensation technique, is designed for ambulatory monitoring of indirect beat-to-beat blood pressure (BP) in the superficial temporal artery. The instrument consists of a small disc-type cuff and a portable unit carried by the subject. Several components are integrated in the cuff for applying counter-pressure to the artery, i.e. a reflectance-type photo-plethysmographic sensor for arterial volume detection, a pressure sensor for cuff pressure Pc measurement and a nozzle flapper-type- electro-pneumatic convertor for controlling Pc. The portable unit includes volume servo control circuitry and a microprocessor-based signal-processing and recording unit. This automatically performs all the necessary measurement procedures and stores into a memory IC element the processed systolic, mean and diastolic blood pressure data, together with pulse intervals on a beat-to-beat basis from the servo-controlled Pc (indirectly measured BP waveform). With this instrument, momentary changes in BP during ambulatory situations such as bicycle ergometer exercise and daily activities including motorway driving are successfully recorded. From the results of simultaneous measurement of the subject's posture changes, the effect of posture change on blood pressure, e.g. baroreceptor-cardiac reflex, is also clearly demonstrated.

  17. Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review

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    Pedro Shiozawa


    Full Text Available We reviewed trigeminal nerve stimulation (TNS and transcutaneous vagus nerve stimulation (tVNS. All techniques have shown preliminary promising results, although the results are mixed. Method: We performed a systematic review of the Medline and Embase databases, with no constraint to dates, through June 2013. The keywords were [(1 trigeminal nerve stimulation OR (2 cranial nerve OR (3 trigemin* OR (4 transcutaneous VNS OR (5 transcutaneous cranial nerve stimulation] and (6 mental disorders. Results: We included four preclinical and clinical five studies on TNS. All clinical data were based on open-label studies with small samples, which diminished the external validity of the results, thus reflecting the modest impact of TNS in current clinical practice. Of the tVNS clinical trials, three assessed physiological features in healthy volunteers, and one examined patients with epilepsy. Conclusion: TNS and tVNS improve treatment of particular neuropsychiatric disorders such as depression.

  18. A greenhouse-gas information system monitoring and validating emissions reporting and mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Jonietz, Karl K [Los Alamos National Laboratory; Dimotakis, Paul E [JPL/CAL TECH; Roman, Douglas A [LLNL; Walker, Bruce C [SNL


    Current GHG-mitigating regimes, whether internationally agreed or self-imposed, rely on the aggregation of self-reported data, with limited checks for consistency and accuracy, for monitoring. As nations commit to more stringent GHG emissions-mitigation actions and as economic rewards or penalties are attached to emission levels, self-reported data will require independent confirmation that they are accurate and reliable, if they are to provide the basis for critical choices and actions that may be required. Supporting emissions-mitigation efforts and agreements, as well as monitoring energy- and fossil-fuel intensive national and global activities would be best achieved by a process of: (1) monitoring of emissions and emission-mitigation actions, based, in part, on, (2) (self-) reporting of pertinent bottom-up inventory data, (3) verification that reported data derive from and are consistent with agreed-upon processes and procedures, and (4) validation that reported emissions and emissions-mitigation action data are correct, based on independent measurements (top-down) derived from a suite of sensors in space, air, land, and, possibly, sea, used to deduce and attribute anthropogenic emissions. These data would be assessed and used to deduce and attribute measured GHG concentrations to anthropogenic emissions, attributed geographically and, to the extent possible, by economic sector. The validation element is needed to provide inde