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Sample records for bloat

  1. Abdominal bloating

    Science.gov (United States)

    ... acarbose, and medicines or foods containing lactulose or sorbitol, may cause bloating. More serious disorders that may ... from foods with high levels of fructose or sorbitol Avoid foods that can produce gas, such as ...

  2. Bloating: Avicenna's Perspective and Modern Medicine.

    Science.gov (United States)

    Naseri, Mohsen; Babaeian, Mahmoud; Ghaffari, Farzaneh; Kamalinejad, Mohammad; Feizi, Awat; Mazaheri, Mohammad; Mokaberinejad, Roshanak; Adibi, Peyman

    2016-04-01

    Bloating and abdominal distention are common complaints present in quite a number of organic and functional diseases. An important subject in traditional Persian medicine is digestive disorders, particularly bloating and its etiology. This is a literature review study conducted on The Canon in Medicine written by Avicenna and using the keywords: bloating, gas. In this article, causes for bloating, according to Avicenna, include diet causes, inappropriate lifestyle, gastrointestinal, and miscellaneous reasons. These were compared with causes suggested in modern medicine. Avicenna classifies causes based on the place of origin into upper part of the abdomen (stomach) and intestinal part of the abdomen. Also, 38 medicinal plants used as remedies were listed. Modern scientific data support all bloating causes that have been mentioned in the canon. Obviously, some causes such as uterine disorders and posterior nasal discharge need to be studied further.

  3. Thermal detoxification and bloating of chromium(VI) with bentonite

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Y.-L., E-mail: yulin@thu.edu.t [Department of Environmental Science and Engineering, Tunghai University, Taichung 40704, Taiwan (China); Hsieh, H.-F.; Peng, Y.-S.; Yang, J.-C. [Department of Environmental Science and Engineering, Tunghai University, Taichung 40704, Taiwan (China); Paul Wang, H. [Department of Environmental Engineering, National Cheng Kung University, Tainan 70101, Taiwan (China); Sustainable Environmental Research Center, National Cheng Kung University, Tainan 70101, Taiwan (China); Lin, C.-Y.; Shih, W.-L.; Hsu, C.-C. [Department of Environmental Science and Engineering, Tunghai University, Taichung 40704, Taiwan (China)

    2010-07-21

    This study stabilizes and bloats Cr(VI)-sorbed bentonite by heating at high temperature. Cr leaching decreases with increasing temperatures. Heating the sample at 1100 {sup o}C results in a non-detectable Cr concentration in the leachate, equivalent to a Cr leaching percent less than 0.001% (i.e., Cr TCLP concentration <0.018 mg of Cr L{sup -1} of leachate). Morphology observed with a scanning electron microscopy indicates the occurrence of sintering of the sample heated at 1100 {sup o}C. The heated samples also show the occurrence of a vesicant process at 1100 {sup o}C. X-ray absorption spectroscopy results indicate that heating at 500 {sup o}C for 4 h can convert approximately 87% Cr(VI) into Cr(III) that is negligibly toxic; Cr{sub 2}O{sub 3} was detected to be the most abundant Cr species. After heating at higher temperatures, namely 900-1100 {sup o}C, almost all doped Cr(VI) is reduced to Cr(III) as inferred from the height of the pre-edge peak of XANES spectra and/or from XANES simulation.

  4. [Using Acupressure to Improve Abdominal Bloating in a Hemicolectomy Patient: A Nursing Experience].

    Science.gov (United States)

    Tseng, Yi-Ling; Hsu, Chun-Hung; Tseng, Hui-Chen

    2015-10-01

    This article describes a nursing experience applying the protocol of bilateral Zusanli (ST-36) acupressure to reduce abdominal bloating in a colon cancer patient who had undergone a right hemicolectomy. The period of care was between November 13 and November 23, 2014. Data were collected through direct care, interviews, observation, and physical assessment. The main health problems of the patient included anxiety, surgical wound pain, and abdominal bloating. We provided pre- and postoperative routine nursing care, wound pain management, and the protocol of Zusanli (ST-36) acupressure for reducing abdominal bloating. Results of care recorded the first passage of flatus and intestinal motility during the second postoperative day, with no complaints of bloating from the fourth postoperative day. The subject exhibited a relaxed mood and slept soundly following each acupressure session. Furthermore, the subject reported experiencing no abdominal bloating during the week following discharge, during which he continued to follow the acupressure protocol. This article provides support via an instance of nursing care for the effectiveness of the Zusanli (ST-36) acupressure in improving abdominal bloating and thus reducing the complications of hemicolectomy surgery.

  5. Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Brian E Lacy

    Full Text Available Abdominal bloating is a common and bothersome symptom of chronic idiopathic constipation. The objective of this trial was to evaluate the efficacy and safety of linaclotide in patients with chronic idiopathic constipation and concomitant moderate-to-severe abdominal bloating.This Phase 3b, randomized, double-blind, placebo-controlled clinical trial randomized patients to oral linaclotide (145 or 290 μg or placebo once daily for 12 weeks. Eligible patients met Rome II criteria for chronic constipation upon entry with an average abdominal bloating score ≥5 (self-assessment: 0 10-point numerical rating scale during the 14-day baseline period. Patients reported abdominal symptoms (including bloating and bowel symptoms daily; adverse events were monitored. The primary responder endpoint required patients to have ≥3 complete spontaneous bowel movements/week with an increase of ≥1 from baseline, for ≥9 of 12 weeks. The primary endpoint compared linaclotide 145 μg vs. placebo.The intent-to-treat population included 483 patients (mean age=47.3 years, female=91.5%, white=67.7%. The primary endpoint was met by 15.7% of linaclotide 145 μg patients vs. 7.6% of placebo patients (P<0.05. Both linaclotide doses significantly improved abdominal bloating vs. placebo (P<0.05 for all secondary endpoints, controlling for multiplicity. Approximately one-third of linaclotide patients (each group had ≥50% mean decrease from baseline in abdominal bloating vs. 18% of placebo patients (P<0.01. Diarrhea was reported in 6% and 17% of linaclotide 145 and 290 μg patients, respectively, and 2% of placebo patients. AEs resulted in premature discontinuation of 5% and 9% of linaclotide 145 μg and 290 μg patients, respectively, and 6% of placebo patients.Once-daily linaclotide (145 and 290 μg significantly improved bowel and abdominal symptoms in chronic idiopathic constipation patients with moderate-to-severe baseline abdominal bloating; in particular

  6. Molecular characterization of the intestinal microbiota in patients with and without abdominal bloating.

    Science.gov (United States)

    Ringel-Kulka, Tamar; Benson, Andrew K; Carroll, Ian M; Kim, Jaehyoung; Legge, Ryan M; Ringel, Yehuda

    2016-03-15

    Recent studies have demonstrated differences in the intestinal microbiota between patients with irritable bowel syndrome (IBS) and healthy controls (HC), suggesting a role for the intestinal microbiota in the pathogenesis of IBS. Alterations in the microbiota have also been implicated in the pathogenesis of abdominal bloating, a commonly reported symptom in IBS. We investigated the relationship between the intestinal microbiota, abdominal bloating, and altered bowel patterns in a cohort of patients with IBS and HC. The 16S rRNA gene from fresh fecal samples was amplified and pyrosequenced by using Roche-454 Titanium chemistry. A Core Measurable Microbiome (CMM) was generated for Operational Taxonomic Unit (OTU) detected in >75% of all samples and compositional features of CMM were compared between groups by Linear Discriminant Analysis (LDA). IBS differentiated from HC by LDA using continuous variation in the species/OTUs or the CMM genera. When subcategorized based on bloating symptoms and bowel characteristics, the same subjects were also well differentiated from one another and from HC. ANOVA analysis showed quantitative species/OTU differences between the subgroups including IBS with and without bloating, and subtypes based on bowel characteristics. The clear LDA differentiation and the significant microbial taxa differences between the groups imply a significant association of the microbiota with bloating symptoms and bowel characteristics in IBS. These changes in the microbiota may serve as a biomarker for IBS and its clinical subtypes and suggest a role for the intestinal microbiota in the pathogenesis of the main symptoms of the disorder.

  7. Restriction of FODMAP in the management of bloating in irritable bowel syndrome.

    Science.gov (United States)

    Wong, Wei Mon

    2016-09-01

    Irritable bowel syndrome (IBS) is a common functional bowel disorder. Up to 96% of IBS patients experience bloating, resulting in poor response to conventional therapies and high consultation rates. Many IBS patients report that food triggers symptoms, particularly diets with poorly absorbed, short-chain carbohydrates, and restrict intake of certain foods to control their symptoms. IBS patients are especially susceptible to an attack due to visceral hypersensitivity. An emerging therapeutic strategy excludes fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) from the diet. There is evidence supporting the efficacy of a low FODMAP diet in improving symptoms of bloating in IBS patients. Individualised, structured dietary guidance may benefit those with persistent troublesome symptoms despite traditional therapies. In view of the multifactorial aetiology of the condition, it is probably best to use a multipronged approach, involving combination therapies, to address bloating in IBS patients.

  8. Holistic Acupuncture approach to idiopathic refractory nausea, abdominal pain and bloating

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    AIM: To evaluate the effectiveness of a holistic acupuncture approach on nausea, pain, bloating and electrogastrogram (EGG) parameters in patients with intractable symptoms. METHODS: Twelve patients with no or mild nausea (those without nausea had bloating or pain) and 10 with a history of moderate to severe nausea were referred for acupuncture. All underwent an EGG and were treated at acupuncture points PC6, SP4 and DU20. Visual analog scales (VAS) assessing severity of nausea, pain and bloating were obtained before and after acupuncture treatment. Nineteen patients received three and three patients received two treatments. RESULTS: VAS scores for nausea reflected the clinical assessment and differed significantly between mild and moderate/severe nausea groups. Acupuncture significantly improved severity of nausea in both groups with improved pre-treatment nausea between the first and third treatments in the moderate/severe nausea group. Pain scores improved with acupuncture in the mild nausea group only and bloating improved only with the first treatment in this group. Patients with bloating with VAS scores greater than 35 pre-treatment improved with acupuncture and over all VAS scores for pain improved with treatment. Acupuncture increased the power in the 2.7 to 3.5 cpm range in the EGG. CONCLUSION: In this uncontrolled clinical study, a holistic acupuncture approach significantly improved nausea in patients with refractory symptoms and increased the power in the 2.7-3.5 cpm component of the electrogastrogram. Bloating and pain VAS scores improved acutely with treatment. This study suggests that acupuncture may be effective in this refractory group of patients and further study using appropriate controls is warranted.

  9. Bloated stars as agn broad line clouds the emission line spectrum

    CERN Document Server

    Alexander, T; Tal Alexander; Hagai Netzer

    1994-01-01

    The `Bloated Stars Scenario' proposes that AGN broad line emission originates in the winds or envelopes of bloated stars (BS). Its main advantage over BLR cloud models is the gravitational confinement of the gas and its major difficulty the large estimated number of BSs and resulting high mass loss rate. We calculate the emission line spectrum by a detailed numerical photoionization code for a wide range of wind structures and a detailed QSO nucleus model with L(ion)=7E45 erg/s, M(bh)=8E7 Mo. The size and boundary density of the BS wind are determined by various processes: Comptonization by the central continuum source, calculated self consistently, tidal disruption by the black hole and the limit set by the wind's finite mass. We find that the emission spectrum is mainly determined by the conditions at the boundary of the line emitting fraction of the wind rather than by its internal structure. Comptonization results in very high ionization parameters at the boundary which produces an excess of unobserved br...

  10. Comparative review of foam formation in biogas plants and ruminant bloat

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, Lucie; Goersch, Kati; Zehnsdorf, Andreas; Mueller, Roland Arno [UFZ - Helmholtz Centre for Environmental Research, Leipzig (Germany). Environmental and Biotechnology Centre; Neuhaus, Juergen [Leipzig Univ. (Germany). Inst. of Bacteriology and Mycology

    2012-12-15

    This review gives an overview of the current knowledge concerning the problem of foam formation in the process of anaerobic digestion in biogas plants that utilize renewable resources or biogenic waste material for biogas production. Process upsets in biogas production induced by foam formation can have a negative impact on the efficiency of biogas plants. The foam can block gas pipes and cause severe damage to the bioreactor equipment, ranging from a failure of the feeders to a damage of the roof of the biogas plant. The most common foam removal methods - stirring in the foam, adding anti-foaming agents, diminishing substrate feeding, and altering the biogas reactor management - are not always successful. However, the reasons for the excessive foam formation during the biogas production process have not yet been elucidated in detail. In contrast, foam building in the rumen of ruminants as a cause for bloat has been studied thoroughly. In general, the interaction between proteins, polysaccharides (mucilage), and small plant particles is assumed to be the crucial factor. As the fermentation process in the rumen has many similarities with the biogas production process, the current research results on bloat in ruminants are summarized and compared with the process of foaming in biogas plants. (orig.)

  11. WASP-86b and WASP-102b: super-dense versus bloated planets

    CERN Document Server

    Faedi, F; Pollacco, D; Brown, D J A; Hébrard, G; Smalley, B; Lam, K W F; Veras, D; Anderson, D; Doyle, A P; Gillon, M; Goad, M R; Lendl, M; Mancini, L; McCormac, J; Plauchu-Frayn, I; Prieto-Arranz, J; Scholz, A; Street, R; Triaud, A H M; West, R; Wheatley, P J; Armstrong, D J; Barros, S C C; Boisse, I; Bouchy, F; Boumis, P; Cameron, A Collier; Haswell, C A; Hay, K L; Hellier, C; Kolb, U; Maxted, P F L; Norton, A J; Osborn, H P; Palle, E; Pepe, F; Queloz, D; Ségransan, D; Udry, S; Wilson, P A

    2016-01-01

    We report the discovery of two transiting planetary systems: a super dense, sub-Jupiter mass planet WASP-86b (\\mpl\\ = 0.82 $\\pm$ 0.06 \\mj, \\rpl\\ = 0.63 $\\pm$ 0.01 \\rj), and a bloated, Saturn-like planet WASP-102b (\\mpl\\ = 0.62 $\\pm$ 0.04 \\mj, \\rpl\\=1.27 $\\pm$ 0.03 \\rj). They orbit their host star every $\\sim$5.03, and $\\sim$2.71 days, respectively. The planet hosting WASP-86 is a F7 star (\\teff\\ = 6330$\\pm$110 K, \\feh\\ = $+$0.23 $\\pm$ 0.14 dex, and age $\\sim$0.8--1~Gyr), WASP-102 is a G0 star (\\teff\\ = 5940$\\pm$140 K, \\feh\\ = $-$0.09$\\pm$ 0.19 dex, and age $\\sim$1~Gyr). These two systems highlight the diversity of planetary radii over similar masses for giant planets with masses between Saturn and Jupiter. WASP-102b shows a larger than model-predicted radius, indicating that the planet is receiving a strong incident flux which contributes to the inflation of its radius. On the other hand, with a density of $\\rho_{pl}$ = 3.24$\\pm$~0.3~$\\rho_{jup}$, WASP-86b is the densest gas giant planet among planets with ma...

  12. Self-pathology, the five-factor model, and bloated specific factors: A cautionary tale.

    Science.gov (United States)

    Oltmanns, Joshua R; Widiger, Thomas A

    2016-04-01

    The five-factor model (FFM) is widely regarded as a useful model for the structure of both normal and maladaptive personality traits. However, recent factor analytic studies have suggested that deficits in the sense of self fall outside the FFM. The current study replicates and extends these findings, illustrating that factors can be situated outside a higher-order domain by including a relatively large number of closely related scales, forming what is known as a bloated specific factor. A total of 1,553 participants (M age = 37.8 years, SD = 13.1) were recruited across 3 studies. One measure of self-pathology (including 15 scales) and 2 measures of the FFM were administered, along with 17 measures of anxiousness and 12 measures of social withdrawal/sociability. Across 2 independent samples and 2 different measures of the FFM, deficits in the sense of self separated from neuroticism when all 15 scales of self-pathology were included. However, self-pathology loaded with FFM neuroticism when only a subset of the self-pathology scales was included. This finding was replicated with measures of social withdrawal/sociability, although only partially replicated with measures of anxiousness. Implications of these findings for past and future factor analytic studies of the structure of psychopathology are discussed.

  13. The living dead: bacterial community structure of a cadaver at the onset and end of the bloat stage of decomposition.

    Directory of Open Access Journals (Sweden)

    Embriette R Hyde

    Full Text Available Human decomposition is a mosaic system with an intimate association between biotic and abiotic factors. Despite the integral role of bacteria in the decomposition process, few studies have catalogued bacterial biodiversity for terrestrial scenarios. To explore the microbiome of decomposition, two cadavers were placed at the Southeast Texas Applied Forensic Science facility and allowed to decompose under natural conditions. The bloat stage of decomposition, a stage easily identified in taphonomy and readily attributed to microbial physiology, was targeted. Each cadaver was sampled at two time points, at the onset and end of the bloat stage, from various body sites including internal locations. Bacterial samples were analyzed by pyrosequencing of the 16S rRNA gene. Our data show a shift from aerobic bacteria to anaerobic bacteria in all body sites sampled and demonstrate variation in community structure between bodies, between sample sites within a body, and between initial and end points of the bloat stage within a sample site. These data are best not viewed as points of comparison but rather additive data sets. While some species recovered are the same as those observed in culture-based studies, many are novel. Our results are preliminary and add to a larger emerging data set; a more comprehensive study is needed to further dissect the role of bacteria in human decomposition.

  14. The mitochondrial and plastid genomes of Volvox carteri: bloated molecules rich in repetitive DNA

    Directory of Open Access Journals (Sweden)

    Lee Robert W

    2009-03-01

    Full Text Available Abstract Background The magnitude of noncoding DNA in organelle genomes can vary significantly; it is argued that much of this variation is attributable to the dissemination of selfish DNA. The results of a previous study indicate that the mitochondrial DNA (mtDNA of the green alga Volvox carteri abounds with palindromic repeats, which appear to be selfish elements. We became interested in the evolution and distribution of these repeats when, during a cursory exploration of the V. carteri nuclear DNA (nucDNA and plastid DNA (ptDNA sequences, we found palindromic repeats with similar structural features to those of the mtDNA. Upon this discovery, we decided to investigate the diversity and evolutionary implications of these palindromic elements by sequencing and characterizing large portions of mtDNA and ptDNA and then comparing these data to the V. carteri draft nuclear genome sequence. Results We sequenced 30 and 420 kilobases (kb of the mitochondrial and plastid genomes of V. carteri, respectively – resulting in partial assemblies of these genomes. The mitochondrial genome is the most bloated green-algal mtDNA observed to date: ~61% of the sequence is noncoding, most of which is comprised of short palindromic repeats spread throughout the intergenic and intronic regions. The plastid genome is the largest (>420 kb and most expanded (>80% noncoding ptDNA sequence yet discovered, with a myriad of palindromic repeats in the noncoding regions, which have a similar size and secondary structure to those of the mtDNA. We found that 15 kb (~0.01% of the nuclear genome are homologous to the palindromic elements of the mtDNA, and 50 kb (~0.05% are homologous to those of the ptDNA. Conclusion Selfish elements in the form of short palindromic repeats have propagated in the V. carteri mtDNA and ptDNA, resulting in the distension of these genomes. Copies of these same repeats are also found in a small fraction of the nucDNA, but appear to be inert in this

  15. Preparation and Bloating Mechanism of Porous Ultra-lightweight Ceramsite by Dehydrated Sewage Sludge and Yellow River Sediments

    Institute of Scientific and Technical Information of China (English)

    YUE Dongting; YUE Qinyan; GAO Baoyu; HE Hongtao; YU Hui; SUN Shenglei; LI Qian; WANG Yan; ZHAO Yu

    2014-01-01

    To solve the disposal problems of solid wastes, dehydrated sewage sludge and Yellow River sediments were tested as components for production of ultra-lightweight ceramsite. The effects of Yellow River sediments addition on the characteristics of ceramsite were investigated. Ceramsite with different Yellow River sediments additions was characterized using thermal analysis, X-ray diffraction, morphological structures analyses, pore size distributions and porosity analyses. Chemical components, especially ratios of SiO2 +Al2O3/Flux, were used to explain the glassy shell formation, physical properties and pores distribution of ultra-lightweight ceramsite;physical forces for instance expansion force and frictional resistance which combined with SiO2+Al2O3/Flux ratios were used to explain the bloating mechanism. Results showed that the maximum addition of Yellow River sediments for making ultra-lightweight ceramsite was 35%. Macropores (between 0.226μm and 0.554μm) of ultra-lightweight ceramsite were dominant in the pore structures of ultra-lightweight ceramsite and its porosity was up to 67.7%. Physical force of expansion force was constant with the variation of Yellow River sediments content and physical force of frictional resistance was decreased with the increase of Yellow River sediments addition. The relationship between expansion and frictional resistance could determine the expansion rate of ceramsite. Larger pores inside the ceramsite bodies could be obtained as Yellow River sediments additions ranged from 10%to 30%. Ceramsite with higher Yellow River sediments additions of 40%(SiO2+Al2O3/Flux ratios 4.25) became denser and have lower porosity. Crystal components analysis proved that the sintering process made some components of raw materials transfer into other crystals having better thermostability.

  16. Belching, Bloating and Flatulence

    Science.gov (United States)

    ... to digest milk sugars (lactose). This condition, called lactose intolerance, is less common in people of northern European ... is an indication of weak abdominal muscles. If lactose intolerance is suspected, milk can be withdrawn from the ...

  17. WASP-78b and WASP-79b: Two highly-bloated hot Jupiter-mass exoplanets orbiting F-type stars in Eridanus

    CERN Document Server

    Smalley, B; Collier-Cameron, A; Doyle, A P; Gillon, M; Hellier, C; Jehin, E; Lendl, M; Maxted, P F L; Pepe, F; Pollacco, D; Queloz, D; Segransan, D; Smith, A M S; Southworth, J; Triaud, A H M J; Udry, S; West, R G

    2012-01-01

    We report the discovery of WASP-78b and WASP-79b, two highly-bloated Jupiter-mass exoplanets orbiting F-type host stars. WASP-78b orbits its V=12.0 host star (TYC 5889-271-1) every 2.175 days and WASP-79b orbits its V=10.1 host star (CD-30 1812) every 3.662 days. A simultaneous fit to WASP and TRAPPIST transit photometry and CORALIE radial-velocity measurements yields planetary masses of 0.89 +/- 0.08 M_Jup and 0.90 +/- 0.08 M_Jup, and radii of 1.70 +/- 0.11 R_Jup and 2.09 +/- 0.14 R_Jup, for WASP-78b and WASP-79b, respectively. The planetary equilibrium temperature of T_P = 2350 +/- 80 K for WASP-78b makes it one of the hottest of the currently known exoplanets. The radius of WASP-79b suggests that it is potentially the largest known exoplanet.

  18. WASP-78b and WASP-79b: two highly-bloated hot Jupiter-mass exoplanets orbiting F-type stars in Eridanus

    Science.gov (United States)

    Smalley, B.; Anderson, D. R.; Collier-Cameron, A.; Doyle, A. P.; Fumel, A.; Gillon, M.; Hellier, , C.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smith, A. M. S.; Southworth, J.; Triaud, A. H. M. J.; Udry, S.; West, R. G.

    2012-11-01

    We report the discovery of WASP-78b and WASP-79b, two highly-bloated Jupiter-mass exoplanets orbiting F-type host stars. WASP-78b orbits its V = 12.0 host star (TYC 5889-271-1) every 2.175 days and WASP-79b orbits its V = 10.1 host star (CD-30 1812) every 3.662 days. Planetary parameters have been determined using a simultaneous fit to WASP and TRAPPIST transit photometry and CORALIE radial-velocity measurements. For WASP-78b a planetary mass of 0.89 ± 0.08 MJup and a radius of 1.70 ± 0.11 RJup is found. The planetary equilibrium temperature of TP = 2350 ± 80 K for WASP-78b makes it one of the hottest of the currently known exoplanets. WASP-79b its found to have a planetary mass of 0.90 ± 0.08 MJup, but with a somewhat uncertain radius due to lack of sufficient TRAPPIST photometry. The planetary radius is at least 1.70 ± 0.11 RJup, but could be as large as 2.09 ± 0.14 RJup, which would make WASP-79b the largest known exoplanet. Photometric data is only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/547/A61Table 1 is available in electronic form at http://www.aanda.org

  19. Determination of clozapine in hair and nail: the role of keratinous biological materials in the identification of a bloated cadaver case.

    Science.gov (United States)

    Chen, Hang; Xiang, Ping; Shen, Min

    2014-02-01

    Keratinous biological materials, such as hair and nails, offer a substantially longer retrospective window of detection compared to other body fluids. Little research on drug analysis in nails is currently being conducted. In this study, the hair and nails from a bloated cadaver was analyzed. The study showed that the forensic toxicology results of keratinous biological materials could provide valuable clues for solving cases. In this study, a method was developed for the extraction and analysis of clozapine from hair and nails. The keratinous bio-samples were washed and then pulverized using a freeze mill. After ultrasonic bath extraction, the supernatants were analyzed by ultra-performance liquid chromatography tandem mass spectrometer (UPLC-MS/MS). The method presented in this study proved to be reliable, specific, selective and sensitive with high precision and accuracy. Clozapine was found in both hair and nails from a long term user's remains, even after serious decomposition. The mean concentration of clozapine in the hair was 322.9 pg/mg and 138.3 pg/mg in the nails. Toxicological results helped police narrow the scope of the investigation and improved the efficiency of the breaking of the case. The findings of the present study demonstrated that the method can be used in forensic investigation. Toxicological results increased the efficiency of cadaver identification and the solving of the case. The study demonstrated that hair and nail analysis could provide vital clues for solving cases and showed the value of keratinous biological materials in the forensics field.

  20. Abdominal bloating and irritable bowel syndrome like symptoms following microinstillation inhalation exposure to chemical warfare nerve agent VX in guinea pigs.

    Science.gov (United States)

    Katos, Alexandre M; Conti, Michele L; Moran, Theodore S; Gordon, Richard K; Doctor, Bhupendra P; Sciuto, Alfred M; Nambiar, Madhusoodana P

    2007-05-01

    While assessing the methylphosphonothioic acid S-(2-(bis(1-methylethyl)amino)ethyl)O-ethyl ester (VX) induced respiratory toxicity and evaluating therapeutics against lung injury, we observed that the animals were experiencing abnormal swelling in the abdominal area. Nerve agent has been known to increase salivary, nasal and gastrointestinal secretion and cause diarrhea. This study was initiated to investigate the effect of VX on the gastrointestinal tract (GI) since abdominal pathology may affect breathing and contribute to the on going respiratory toxicity. The mid-abdominal diameter and the size of the lower left abdomen was measured before and after 27.3 mg/m3 VX exposure by microinstillation and at 30 min intervals up to 2 h post-VX exposure. Both VX and saline exposed animals exhibited a decrease in circumference of the upper abdomen, although the decrease was slightly higher in VX-exposed animals up to 1 h. The waist diameter increased slightly in VX-exposed animals from 60 to 90 min post-VX exposure but was similar to saline controls. The lower left abdomen near to the cecum, 6 cm below and 2cm to the right of the end of the sternum, showed an increase in size at 30-60 min that was significantly increased at 90-120 min post-VX exposure. In addition, VX-exposed animals showed loose fecal matter compared to controls. Necropsy at 24h showed an increased small intestine twisting motility in VX-exposed animals. Body tissue AChE assay showed high inhibition in the esophagus and intestine in VX-exposed animals indicating that a significant amount of the agent is localized to the GI following microinstillation exposure. These results suggest that microinstillatipn inhalation VX exposure induces gastrointestinal disturbances similar to that of irritable bowel syndrome and bloating.

  1. Timpanismo espumoso em bovinos leiteiros em pastagens de Trifolium spp. (Leg.Caesalpinoideae Leguminous bloat in dairy cattle on Trifolium spp. pastures

    Directory of Open Access Journals (Sweden)

    André Gustavo Cabrera Dalto

    2009-05-01

    Full Text Available O pastejo de plantas leguminosas que provocam fermentação excessiva pode causar surtos de timpanismo e mortes em ruminantes. Em uma propriedade no município de São Francisco de Paula, Rio Grande do Sul, oito bovinos de um total de 66 morreram subitamente, ao haverem sido transferidos de um potreiro de campo nativo, para outro cuja pastagem era composta por Trifolium repens e Trifolium pratense. Os animais foram encontrados mortos no amanhecer do dia seguinte à transferência, não foram observados sinais clínicos prévios. Os principais achados macroscópicos incluíram aumento de volume abdominal, protrusão de vagina e língua, distensão ruminal, fígado de coloração pálida e aumento do baço. Na histologia, havia congestão e edema pulmonares e hiperplasia linfóide difusa e acentuada no baço. A evidência de ingestão das leguminosas associada aos achados patológicos e à ausência de microrganismos no exame bacteriológico confirmaram o diagnóstico de timpanismo.Leguminous bloat may occur in cattle which graze pastures consisting of lush forages. In a dairy farm located on the municipality of São Francisco de Paula, Rio Grande do Sul, eight out of 66 cows died suddenly after being transferred to a paddock whose pastures were composed of Trifolium repens and Trifolium pratense. Animals were found dead in the morning of the next day after being transferred; no clinical signs were noticed. Main gross findings included enhanced abdominal volume, protrusion and congestion of the tongue and vagina, ruminal distension, pale liver, and enhanced spleen. Histologically, there were lung congestion and edema, and splenic lymphoid hyperplasia. The evidence of leguminous forages consumption associated with the pathological findings and the absence of growth on bacteriology confirmed the diagnosis.

  2. How bloated is the Dutch housing market?

    NARCIS (Netherlands)

    Francke, M.K.

    2010-01-01

    Is the Dutch housing market overvalued and, if so, to what degree? Are the home prices too steep in comparison to other economic data, such as interest rates and income? Can we expect a bubble to burst, causing a collapse of the market similar to what has happened in the United States of America? Af

  3. 纳子法耳穴埋籽联合随身灸治疗妇科术后腹胀的效果观察%Effect observation of ear acupoint seeds burying with Nazi combined moxibustion treatment bloating after gynecological surgery

    Institute of Scientific and Technical Information of China (English)

    张宇娟; 石夏君; 黄天宇

    2015-01-01

    目的:观察纳子法耳穴埋籽联合随身灸在治疗妇科腹部手术术后腹胀的效果。方法:将156例患者随机等分为对照组和观察组,对照组进行常规治疗与护理,术后6 h 内禁食水、早期下床活动、腹部按摩、饮用萝卜汤及橙皮水等方法,观察组患者在采用常规治疗与护理基础上在术后6 h 给予纳子法耳穴埋籽,术后12 h 起予随身灸直至肛门排气或腹胀消失。比较两组患者疗效。结果:观察组患者疗效优于对照组,差异有统计学意义(P ﹤0.05)。结论:纳子法耳穴埋籽联合随身灸能促进肛门矢气,减轻或消除妇科患者术后腹胀。合理运用纳子法耳穴埋籽和随身灸是治疗妇产科术后患者腹胀的关键。%Objective:To observaion the effect of ear acupoint seeds burying with hour - prescription of acupoints combined moxibustion treatment of bloating after gynecological abdominal surgery. Methods:The 156 cases of patients were randomly divided into control group and observation group,the control group received routine treatment and care,within 6 h after water fasting,early ambulation,abdominal massage,drinking carrot soup and orange peel water,while the observation group with conventional treatment and care on the basis of the 6 h after administration with ear acupoint seeds burying,after 12 h since I carry moxibustion until flatus or bloating disappear. Comparison of the efficacy of the two groups of patients. Results:The effect of observation group was better than the control group(P ﹤ 0. 05). Conclusion:Ear acupoint seeds burying with Nazi can promote joint portable moxibustion anus vector gas,gynecological sur-gery patients to reduce or eliminate bloating. Rational use of child law is satisfied ear buried seeds and carry moxibustion is the key to treatment of obstetrics and gynecology postoperative abdominal distention.

  4. Bloat and colic in horses experimentally induced by the ingestion of Panicum maximum cv. ‘Mombaça’ Timpanismo e cólica em equinos induzidos experimentalmente pela ingestão de Panicum maximum cv. ‘Mombaça’

    Directory of Open Access Journals (Sweden)

    Valíria Duarte Cerqueira

    2012-11-01

    Full Text Available In the Amazon region, sprouting pastures of Panicum maximum cause colic and death in horses and mules. To produce the disease two experiments were performed with growing P. maximum cv. 'Mombaça' in penned horses. In Experiment 1, at the beginning of the raining season, 10 horses were fed with recently harvested sprouting P. maximum. Two horses showed colic on the 5th and 11th day after start of the ingestion. In Experiment 2, also during the raining season, the same 10 horses used in Experiment 2 were divided into two groups of 5 horses each. Group 1 received sprouting P. maximum immediately after harvested and Group 2 received the grass 24 hours after harvested. The control group consisted of four animals which were placed in individual pens and fed with Pennisetum purpureum and commercial ration twice a day. One horse from Group 2 showed colic on day 13th after the start of feeding. The other horses of both groups showed intestinal bloat. In both experiments affected horses recovered after the end of the administration. The control group did not showed clinical signs. These results demonstrated that the disease is caused by the ingestion of sprouting P. maximum during the rainy season. The results in experiment 2 showed that P. maximum do not loss toxicity 24 hours after harvesting. Clinical signs suggest that primary alteration caused by P. maximum is intestinal fermentation followed by bloat.Na região Amazônica, Panicum maximum em brotação causa cólica em equinos durante o período chuvoso. Com o objetivo de reproduzir experimentalmente a doença, foram realizados dois experimentos com P. maximum cv. 'Mombaça' em brotação. No Experimento 1, 10 equinos receberam o capim em brotação, ofertado no coxo. Dois animais apresentaram cólica, um no 5° dia e outro no 11° dia de experimento. No Experimento 2, também durante a época de chuvas, os mesmos 10 animais foram separados em dois grupos de 5, um grupo recebia P. maximum rec

  5. VLT transit and occultation photometry for the bloated planet CoRoT-1b

    OpenAIRE

    Gillon, Michaël; Demory, B. -O.; Triaud, A. H. M. J.; Barman, T; Hebb, L.; Montalban Iglesias, Josefa; Maxted, P.; Queloz, D; Deleuil, M.; Magain, Pierre

    2009-01-01

    We present VLT eclipse photometry for the giant planet CoRoT-1b. We observed a transit in the R-band filter and an occultation in a narrow filter centered on 2.09 microns. Our analysis of this new photometry and published radial velocities, in combination with stellar-evolutionary modeling, leads to a planetary mass and radius of 1.07 (+0.13,-0.18) M_Jup and 1.45 (+0.07,-0.13) R_Jup, confirming the very low density previously deduced from CoRoT photometry. The large occultation depth that we ...

  6. VLT transit and occultation photometry for the bloated planet CoRoT-1b

    CERN Document Server

    Gillon, M; Triaud, A H M J; Barman, T; Hebb, L; Montalban, J; Maxted, P F L; Queloz, D; Deleuil, M; Magain, P

    2009-01-01

    We present VLT eclipse photometry for the giant planet CoRoT-1b. We observed a transit in the R-band filter and an occultation in a narrow filter centered on 2.09 microns. Our analysis of this new photometry and published radial velocities, in combination with stellar-evolutionary modeling, leads to a planetary mass and radius of 1.07 (+0.13,-0.18) M_Jup and 1.45 (+0.07,-0.13) R_Jup, confirming the very low density previously deduced from CoRoT photometry. The large occultation depth that we measure at 2.09 microns (0.278 (+0.043,-0.066) %) is consistent with thermal emission and is better reproduced by an atmospheric model with no redistribution of the absorbed stellar flux to the night side of the planet.

  7. Is tidal heating sufficient to explain bloated exoplanets? Consistent calculations accounting for finite initial eccentricity

    CERN Document Server

    Leconte, Jérémy; Baraffe, Isabelle; Levrard, Benjamin

    2010-01-01

    In this paper, we present the consistent evolution of short-period exoplanets coupling the tidal and gravothermal evolution of the planet. Contrarily to previous similar studies, our calculations are based on the complete tidal evolution equations of the Hut model, valid at any order in eccentricity, obliquity and spin. We demonstrate, both analytically and numerically, that, except if the system was formed with a nearly circular orbit (e<0.2), solving consistently the complete tidal equations is mandatory to derive correct tidal evolution histories. We show that calculations based on tidal models truncated at second order in eccentricity, as done in all previous studies, lead to erroneous tidal evolutions. As a consequence, tidal energy dissipation rates are severely underestimated in all these calculations and the characteristic timescales for the various orbital parameters evolutions can be wrong by up to three orders in magnitude. Based on these complete, consistent calculations, we revisit the viabili...

  8. Three irradiated and bloated hot Jupiters: WASP-76b, WASP-82b & WASP-90b

    CERN Document Server

    West, R G; Anderson, D R; Bouchy, F; Brown, D J A; Cameron, A Collier; Deleuil, M; Delrez, L; Doyle, A P; Faedi, F; Fumel, A; Gillon, M; Hebrard, G; Hellier, C; Jehin, E; Lendl, M; Maxted, P F L; Pepe, F; Pollacco, D; Queloz, D; Segransan, D; Smalley, B; Smith, A M S; Triaud, A H M J; Udry, S

    2016-01-01

    We report three new transiting hot-Jupiter planets discovered from the WASP surveys combined with radial velocities from OHP/SOPHIE and Euler/CORALIE and photometry from Euler and TRAPPIST. All three planets are inflated, with radii 1.7-1.8 Rjup. All orbit hot stars, F5-F7, and all three stars have evolved, post-MS radii (1.7-2.2 Rsun). Thus the three planets, with orbits of 1.8-3.9 d, are among the most irradiated planets known. This reinforces the correlation between inflated planets and stellar irradiation.

  9. Three irradiated and bloated hot Jupiters:. WASP-76b, WASP-82b, and WASP-90b

    Science.gov (United States)

    West, R. G.; Hellier, C.; Almenara, J.-M.; Anderson, D. R.; Barros, S. C. C.; Bouchy, F.; Brown, D. J. A.; Collier Cameron, A.; Deleuil, M.; Delrez, L.; Doyle, A. P.; Faedi, F.; Fumel, A.; Gillon, M.; Gómez Maqueo Chew, Y.; Hébrard, G.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smalley, B.; Smith, A. M. S.; Southworth, J.; Triaud, A. H. M. J.; Udry, S.

    2016-01-01

    We report on three new transiting hot Jupiter planets, discovered from the WASP surveys, which we combine with radial velocities from OHP/SOPHIE and Euler/CORALIE and photometry from Euler and TRAPPIST. The planets WASP-76b, WASP-82b, and WASP-90b are all inflated, with radii of 1.7-1.8 RJup. All three orbit hot stars, of type F5-F7, with orbits of 1.8-3.9 d, and all three stars have evolved, post-main-sequence radii (1.7-2.2 R⊙). Thus the three planets fit a known trend of hot Jupiters that receive high levels of irradiation being highly inflated. We caution, though, about the presence of a selection effect, in that non-inflated planets around ~2 R⊙ post-MS stars can often produce transits too shallow to be detected by the ground-based surveys that have found the majority of transiting hot Jupiters. Tables of the photometry and radial velocity are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/585/A126

  10. Genetic Program Based Data Mining of Fuzzy Decision Trees and Methods of Improving Convergence and Reducing Bloat

    Science.gov (United States)

    2007-04-01

    A data mining procedure for automatic determination of fuzzy decision tree structure using a genetic program (GP) is discussed. A GP is an algorithm...that evolves other algorithms or mathematical expressions. Innovative methods for accelerating convergence of the data mining procedure and reducing...Finally, additional methods that have been used to validate the data mining algorithm are referenced.

  11. The Transit Light Curve Project. VII. The Not-So-Bloated Exoplanet HAT-P-1b

    CERN Document Server

    Winn, Joshua N; Bakos, Gaspar A; Pal, Andras; Johnson, John Asher; Williams, Peter K G; Shporer, Avi; Mazeh, Tsevi; Fernandez, Jose; Latham, David W

    2007-01-01

    We present photometry of the G0 star HAT-P-1 during six transits of its close-in giant planet, and we refine the estimates of the system parameters. Relative to Jupiter's properties, HAT-P-1b is 1.20 +/- 0.05 times larger and its surface gravity is 2.7 +/- 0.2 times weaker. Although it remains the case that HAT-P-1b is among the least dense of the known sample of transiting exoplanets, its properties are in accord with previously published models of strongly irradiated, coreless, solar-composition giant planets. The times of the transits have a typical accuracy of 1 min and do not depart significantly from a constant period.

  12. Ovarian Cancer Fact Sheet

    Science.gov (United States)

    ... pelvis or abdomen (belly) Bloating in the abdomen Urinary urgency (needing to pee right away) Urinary frequency (having ... pelvis or abdomen (belly) Bloating in the abdomen Urinary urgency (needing to pee right away) Urinary frequency (having ...

  13. Medications (for IBS)

    Medline Plus

    Full Text Available ... with Diarrhea Nausea and IBS Bloating in IBS Sleep and Irritable Bowel Syndrome Gynecological Aspects of Irritable ... with Diarrhea Nausea and IBS Bloating in IBS Sleep and Irritable Bowel Syndrome Gynecological Aspects of Irritable ...

  14. Chromium in diet

    Science.gov (United States)

    The best source of chromium is brewer's yeast. However, many people do not use brewer's yeast because it causes bloating ( abdominal distention ) and nausea . Other good sources of chromium include ...

  15. Jejunostomy feeding tube

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000181.htm Jejunostomy feeding tube To use the sharing features on this ... vomiting Your child's stomach is bloated Alternate Names Feeding - jejunostomy tube; G-J tube; J-tube; Jejunum ...

  16. Bugs on the brain; brain in the gut--seeking explanations for common gastrointestinal symptoms.

    LENUS (Irish Health Repository)

    Quigley, E M M

    2013-03-01

    Gastrointestinal symptoms such as heartburn, indigestion (or dyspepsia), bloating, distension, constipation, abdominal pain, abdominal discomfort and diarrhoea are extremely common worldwide. For some, such symptoms can prove to be chronic and disabling.

  17. Sertraline

    Science.gov (United States)

    Sertraline is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and ... including mood swings, irritability, bloating, and breast tenderness. Sertraline is in a class of antidepressants called selective ...

  18. Food Allergies

    Science.gov (United States)

    ... digesting the sugar in milk. This is called "lactose intolerance," and it isn't an allergy because it ... t involve the immune system. The symptoms of lactose intolerance are bloating, cramping, nausea, gas and diarrhea. SymptomsWhat ...

  19. Hangekobokuto (Banxia-houpo-tang, a Kampo Medicine that Treats Functional Dyspepsia

    Directory of Open Access Journals (Sweden)

    Tetsuro Oikawa

    2009-01-01

    Full Text Available Although abdominal bloating is one of the most bothersome symptoms experienced by patients with functional dyspepsia (FD, therapeutic drugs to relieve abdominal bloating have not been established. We investigated the Kampo (Chinese herbal medicine, Hangekobokuto (Banxia-houpo-tang, HKT for patients with FD from the standpoint of bowel gas retention. The bowel gas volume calculated from a plain abdominal radiogram (gas volume score, GVS in FD patients was significantly higher than that in healthy subjects. Two week administration of HKT in the FD patients showed a significant decrease of GVS. Furthermore, gastrointestinal symptoms, especially symptoms of abdominal pain, indigestion and constipation, all of which are closely related to abdominal bloating, improved significantly in FD patients after the administration of HKT. These results suggest that HKT improves abdominal bloating accompanied by the reduction of bowel gas in FD patients.

  20. Low-fiber diet

    Science.gov (United States)

    ... slow your bowel movements. This helps decrease diarrhea, gas, and bloating. Your doctor may recommend that you follow a low-fiber diet when you have a flare-up of: Irritable bowel syndrome Diverticulitis Crohn disease ...

  1. National Ovarian Cancer Coalition

    Science.gov (United States)

    ... List Signs & Symptoms Potential signs and symptoms of ovarian cancer: Bloating Pelvic or abdominal pain Trouble eating or ... to urinate urgently or often Other symptoms of ovarian cancer can include: Fatigue Upset stomach or heartburn Back ...

  2. Indigestion

    Science.gov (United States)

    ... 2011:chap 139. Read More Abdominal bloating Belching Depression - overview Fiber Heart attack Nausea and vomiting - adults Stress and your health Patient Instructions Taking antacids Review Date 1/11/2015 Updated by: Todd Eisner, ...

  3. Too Much Vitamin C: Harmful?

    Science.gov (United States)

    ... Nausea Vomiting Heartburn Abdominal bloating and cramps Headache Insomnia Kidney stones Remember, for most people, a healthy ... Original article: http://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/vitamin-c/faq- ...

  4. Identifying and individuating cognitive systems: a task-based distributed cognition alternative to agent-based extended cognition.

    Science.gov (United States)

    Davies, Jim; Michaelian, Kourken

    2016-08-01

    This article argues for a task-based approach to identifying and individuating cognitive systems. The agent-based extended cognition approach faces a problem of cognitive bloat and has difficulty accommodating both sub-individual cognitive systems ("scaling down") and some supra-individual cognitive systems ("scaling up"). The standard distributed cognition approach can accommodate a wider variety of supra-individual systems but likewise has difficulties with sub-individual systems and faces the problem of cognitive bloat. We develop a task-based variant of distributed cognition designed to scale up and down smoothly while providing a principled means of avoiding cognitive bloat. The advantages of the task-based approach are illustrated by means of two parallel case studies: re-representation in the human visual system and in a biomedical engineering laboratory.

  5. Multiple endocrine neoplasia (MEN) I

    Science.gov (United States)

    ... at any age, and it affects men and women equally. A family history of this disorder raises your risk. Symptoms Symptoms vary from person to person, and depend on which gland is involved. They may include: Abdominal pain Anxiety Black, tarry stools Bloated feeling after meals Burning, ...

  6. Diversity of condensed tannin structures affects rumen in vitro methane production in sainfoin (Onobrychis viciifolia) accessions

    NARCIS (Netherlands)

    Hatew, B.; Hayot Carbonero, C.; Stringano, E.; Sales, L.F.; Smith, L.M.J.; Mueller-Harvey, I.; Hendriks, W.H.; Pellikaan, W.F.

    2015-01-01

    Sainfoin is a non-bloating temperate forage legume with a moderate-to-high condensed tannin (CT) content. This study investigated whether the diversity of sainfoin accessions in terms of CT structures and contents could be related to rumen in vitro gas and methane (CH4) production and fermentation c

  7. Deepening Corporate Integrity in the Nigerian University System

    Science.gov (United States)

    Ejiogu, Aloy; Onyene, Virgy

    2008-01-01

    The quest and agitation for the enthronement of corporate integrity in the nation's universities by the stakeholders have become almost hysterical given the often alleged, sometimes proven, cases of mal-administration, fund embezzlement and or misappropriation, over bloated or even fake invoicing, unbridled favoritism, sexual harassment, bribery,…

  8. The Cost of Chaos in the Curriculum. Perspectives on Higher Education

    Science.gov (United States)

    Capaldi Phillips, Elizabeth D.; Poliakoff, Michael B.

    2015-01-01

    ACTA's report "The Cost of Chaos in the Curriculum" reveals that the vast array of course choices given to college students is a cause of exploding costs and poor academic outcomes. And a bloated undergraduate curriculum is particularly detrimental to the success of students from lower socioeconomic backgrounds. The report documents how…

  9. Healthlines | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... disease get gas, diarrhea, or bloating after eating gluten. These symptoms could be caused by intolerance to the protein or a wheat allergy, but celiac disease is different. When a person with celiac disease eats or drinks anything with gluten, the body's immune system attacks the inside of ...

  10. What Is Celiac Disease? How Do I Live with It?

    Science.gov (United States)

    Blaska, Joan

    2007-01-01

    Celiac disease, also known as celiac sprue, is a hereditary, autoimmune disease that causes a sensitivity to gluten, which is a protein found in wheat, rye, and barley. The key symptoms of celiac disease are diarrhea, constipation, gas, bloating, backaches, stomachaches, nausea, anemia, fatigue, osteoporosis, stunted growth in children, and weight…

  11. A Randomised Controlled Trial on hypnotherapy for Irritable Bowel Syndrome : design and methodological challenges (the IMAGINE study)

    NARCIS (Netherlands)

    Flik, Carla E.; van Rood, Yanda R.; Laan, Wijnand; Smout, Andre J. P. M.; Weusten, Bas L. A. M.; Whorwell, Peter J.; de Wit, Niek J.

    2012-01-01

    Background: Irritable Bowel Syndrome (IBS) is a common gastro-intestinal disorder in primary and secondary care, characterised by abdominal pain, discomfort, altered bowel habits and/or symptoms of bloating and distension. In general the efficacy of drug therapies is poor. Hypnotherapy as well as Co

  12. Why Does College Cost So Much?

    Science.gov (United States)

    Archibald, Robert B.; Feldman, David H.

    2010-01-01

    Much of what is written about colleges and universities ties rapidly rising tuition to dysfunctional behavior in the academy. Common targets of dysfunction include prestige games among universities, gold plated amenities, and bloated administration. This book offers a different view. To explain rising college cost, the authors place the higher…

  13. Irritable bowel syndrome

    Science.gov (United States)

    ... or more. The main symptoms include: Abdominal pain Gas Fullness Bloating Change in bowel habits Pain and other symptoms will often be reduced or go away after a bowel movement. Symptoms may flare up when there is a change in the ...

  14. Education or Reputation? A Look at America's Top-Ranked Liberal Arts Colleges

    Science.gov (United States)

    Poliakoff, Michael; Alacbay, Armand

    2014-01-01

    ACTA [American Council of Trustees and Alumni] today released a report that examines the country's most prestigious liberal arts colleges. Despite endowments soaring as high as $1.8 billion, nearly all institutions increased tuition during the Great Recession to finance bloated administrative spending, with many college presidents enjoying…

  15. Carbohydrate digestion in congenital sucrase isomaltase deficient and recurrent abdominal pain children assesed by 13C- starch breath test

    Science.gov (United States)

    Starches contribute about half of the food energy needs to the weaned child's diet. Malabsorption of sucrose is associated with abdominal pain, bloating and diarrhea. A genetic disorder called Congenital Sucrase-Isomaltase Deficiency (CSID) is suspected when these symptoms follow sugar ingestion and...

  16. 78 FR 47154 - Food Labeling; Gluten-Free Labeling of Foods

    Science.gov (United States)

    2013-08-05

    ...,'' affecting the digestive tract (e.g., abdominal bloating; cramping and pain; chronic diarrhea; vomiting... ``permit a more rapid development of dependable and affordable technologies for testing gluten... limit our flexibility and possibly deter the development of new and better analytical methods. We...

  17. Fatal thrombotic complications of hepatic cystic compression of the inferior vena: A case report

    Institute of Scientific and Technical Information of China (English)

    Ting-Kai Leung; Chi-Ming Lee; Hsin-Chi Chen

    2005-01-01

    Of 5% of patients who develop liver cysts, only 10-15%of them come for medical attention, typically because of dull right upper quadrant pain, abdominal bloating or early satiety. We treated a 77-year-old female with a rare complication of inferior vena cava thrombosis. The patient expired due to septic shock and multiple organ failure.

  18. Non-pharmacological treatments in the irritable bowel syndrome

    Institute of Scientific and Technical Information of China (English)

    A Leahy; O Epstein

    2001-01-01

    @@INTRODUCTION The irritable bowel syndrome (IBS) is a gastrointestinal disorder characteried by chronic lower abdominal pain and disordered defaecation associated with bloating ,tenesmus and extra-intestinal symptoms including and functional upper gastrointestinal symptoms .Currently there is nounifying hypothesis which adepuately explains the pathogenesis of the disorder although a number of physiological and psychological abmormalites have been described.

  19. 78 FR 3333 - Spiromesifen; Pesticide Tolerances

    Science.gov (United States)

    2013-01-16

    ..., bloated stomachs, and pale liver), and decreased spleen weights. Cancer (Oral, dermal, inhalation... (free and conjugated). 2. Dietary exposure from drinking water. The Agency used screening level water... Provisional Cranberry Model and Screening Concentration in Ground Water (SCI-GROW) models the...

  20. High forage quality helps maintain resilience to gastrointestinal parasites in sheep and goats

    Science.gov (United States)

    Condensed tannins (CT) in browse and forage plants can have positive or negative effects on livestock health and performance, depending on the type and concentration of CT present in the diet. Historically, bloating in ruminants was reduced or eliminated when grazing legumes that contained CT. Con...

  1. Kronisk obstipation og betydning af livsstilsfaktorer

    DEFF Research Database (Denmark)

    Borre, Mette; Qvist, Niels; Raahave, Dennis;

    2015-01-01

    First-line treatment of constipation includes dietary fibre, fluid and exercise. The evidence for these recommendations is, however, scarce. Increased intake of fibre will reduce colonic transit time and improve the frequency and consistency of stools in 50% of patients. Bloating and flatulence...

  2. Waist-High and Knee-Deep: Humane Learning beyond Polemics and Precincts

    Science.gov (United States)

    Higgins, Chris

    2015-01-01

    In this essay, Chris Higgins sets out to disentangle the tradition of humane learning from contemporary distinctions and debates. The first section demonstrates how a bloated and incoherent "humanism" now functions primarily as a talisman or a target, that is, as a prompt to choose sides. It closes with the image of Doris Salcedo's…

  3. Acute oral administration of lauric acid reduces energy intake in healthy male

    DEFF Research Database (Denmark)

    Feltrin, K. L.; Brennan, I.M.; Rades, Thomas

    2014-01-01

    12 would result in a dose-related suppression of appetite and subsequent energy intake at breakfast and lunch. Methods 14 healthy men were studied on four separate occasions in double-blind, randomised fashion. Following ingestion of C12 (2 g (77 kJ), 4 g (153 kJ), or 6 g (230 kJ)) or control, energy...... intake at breakfast (30 min after C12 ingestion), perceptions of appetite, nausea and bloating (for 180 min following breakfast), and energy intake at lunch (180 min after breakfast), were measured. Results C12 ingestion did not induce nausea or bloating. While there was no effect of C12 on energy intake...... at breakfast, energy intake at lunch was reduced significantly after ingestion of both C12(2 g) (by 13.7%, P

  4. Irritable bowel syndrome: focus on otilonium bromide.

    Science.gov (United States)

    Boeckxstaens, Guy; Clavé, Pere; Corazziari, Enrico S; Tack, Jan

    2014-02-01

    Irritable bowel syndrome is a prevalent and chronic disorder, characterized by recurrent abdominal pain/discomfort, bloating and altered bowel habits. This condition affects an estimated 10-15% of the population worldwide and impacts heavily on a patient's daily life and ability to work, as well as healthcare resource utilization. Drug therapy aimed at correcting the primary symptoms of diarrhea/constipation/bloating may have little effect on abdominal pain, which results from visceral hypersensitivity. Smooth muscle relaxants or antispasmodics decrease the tone and contractility of intestinal smooth muscle, effectively managing abdominal pain. Otilonium bromide has been widely used worldwide and has been found to be safe and well tolerated, and superior to placebo for the reduction of symptoms and the prevention of symptom relapse in patients with irritable bowel syndrome.

  5. Comparing the Effects of Yoga & Oral Calcium Administration in Alleviating Symptoms of Premenstrual Syndrome in Medical Undergraduates

    OpenAIRE

    Mehta Bharati

    2016-01-01

    Introduction: Medical undergraduates are heavily burdened by their curriculum. The females, in addition, suffer from vivid affective or somatic premenstrual syndrome (PMS) symptoms such as bloating, mastalgia, insomnia, fatigue, mood swings, irritability, and depression. The present study was proposed to attenuate the symptoms of PMS by simple lifestyle measures like yoga and/or oral calcium. Methods: 65 medical female students (18-22 years) with a...

  6. Severe idiopathic hypocalcemia in a juvenile western lowland gorilla, Gorilla gorilla gorilla.

    Science.gov (United States)

    Chatfield, Jenifer; Stones, Greeley; Jalil, Tania

    2012-03-01

    A 6-mo-old, male western lowland gorilla (Gorilla gorilla gorilla) was evaluated because of tetany of both hands. The gorilla had alternating periods of constipation, diarrhea, and bloating since birth. A diagnosis of idiopathic hypocalcemia was based on severe hypocalcemia, a normal vitamin D level, response to oral calcium and vitamin D therapy, and eventual resolution. Idiopathic hypocalcemia, an uncommon disease in neonatal humans, should be considered in young gorillas with persistent gastrointestinal problems or acute tetany.

  7. Perbedaan Depresi Pada Pasien Dispepsia Fungsional dan Dispepsia Organik

    OpenAIRE

    Tarigan, Citra Julita

    2003-01-01

    The word dispepsia is a medical term that refers to a vague constellation of upper abdominal symptoms. Patients more commonly refer to this symptom, as indigestior Which is used sinonymously. Dispepsia is an extremely common condition. Dispepsia is the Fourth most common medical diagnosis. Defined dispepsia as episodic or persistent abdominal discomfort that is located in upper abdomen or epigastria. Other symptoms, such as bloating early satiety, distendon, and nausea, are commonly present. ...

  8. Lactose intolerance – current state of knowledge

    OpenAIRE

    Edyta Mądry; Ewa Fidler; Jarosław Walkowiak

    2010-01-01

    Lactase-phlorizin hydrolase (LCT), more commonly known as lactase, is an enzyme responsible for cleaving lactose into absorbable monosaccharides, glucose and galactose. LCT deficiency (hypolactasia – HL) is caused by a decreased activity of LCT in the small intestinal villi and potentially results in lactose malabsorption what may lead to the development of clinical symptoms (diarrhea, bloating, flatulence and cramps) andavoiding milk products in the diet. HL is the world’...

  9. Lactose Intolerance and the Irritable Colon

    OpenAIRE

    McSherry, J. A.

    1982-01-01

    Symptoms of lactase deficiency include nausea, abdominal pain, distension, bloating and diarrhea after ingesting foods which contain lactose. Lactose intolerance and bowel motility disorders have similar symptoms, and people with irritable bowel syndrome and unexplained abdominal pain may have lactose intolerance. A definite diagnosis can be made by detecting hydrogen in the breath after a lactose load, by lactase assay from a small bowel biopsy specimen or by lactose intolerance testing. Lac...

  10. Lactose malabsorption and intolerance: pathogenesis, diagnosis and treatment

    OpenAIRE

    Misselwitz, B.; Pohl, D.; Fruhauf, H; Fried, M; Vavricka, S R; Fox, Mark

    2013-01-01

    Lactose malabsorption is a common condition caused by reduced expression or activity of lactase in the small intestine. In such patients, lactose intolerance is characterized by abdominal symptoms (e.g. nausea, bloating, and pain) after ingestion of dairy products. The genetic basis of lactose malabsorption is established and several tests for this condition are available, including genetic, endoscopic, and H2-breath tests. In contrast, lactose intolerance is less well understood. Recent stud...

  11. Microscopic colitis: a review for the surgical endoscopist

    OpenAIRE

    Datta, Indraneel; Brar, Savtaj S.; Andrews, Christopher N; Dupre, Marc; Ball, Chad G.; Buie, W. Donald; Beck, Paul L.

    2009-01-01

    Microscopic colitis (MC) is an inflammatory condition of the colon distinct from Crohn disease or ulcerative colitis that can cause chronic diarrhea as well as cramping and bloating. Although it was first described 30 years ago, awareness of this entity as a cause of diarrhea has only become more widespread recently. Up to 20% of adults with chronic diarrhea who have an endoscopically normal colonoscopy may have MC. Endoscopic and radiological examinations are usually normal, but histology re...

  12. Carbon Dioxide Insufflation in Routine Colonoscopy Is Safe and More Comfortable: Results of a Randomized Controlled Double-Blinded Trial

    Directory of Open Access Journals (Sweden)

    M. Geyer

    2011-01-01

    Full Text Available Many patients experience pain and discomfort after colonoscopy. Carbon dioxide (CO2 can reduce periprocedural pain although air insufflation remained the standard procedure. The objective of this double-blinded, randomized controlled trial was to evaluate whether CO2 insufflation does decrease pain and bloating during and after colonoscopy compared to room air. Methods. 219 consecutive patients undergoing colonoscopy were randomized to either CO2 or air insufflation. Propofol was used in all patients for sedation. Transcutaneous CO2 was continuously measured with a capnograph as a safety parameter. Pain, bloating, and overall satisfaction were assessed at regular intervals before and after the procedure. Results(data are mean ±SD. 110 patients were randomized to CO2 and 109 to room air. The baseline characteristics were similar in both groups. The mean propofol dose was not different between the treatments, as were the time to reach the ileum and the withdrawal time. pCO2 at the end of the procedure was 35.2±4.3 mmHg (CO2 group versus 35.6±6.0 mmHg in the room air group (>.05. No relevant complication occurred in either group. There was significantly less bloating for the CO2 group during the postprocedural recovery period (<.001 and over the 24-hour period (<.001. Also, patients with CO2 insufflation experienced significantly less pain (=.014. Finally, a higher overall satisfaction (=.04 was found in the CO2 group. Conclusions. This trial provides compelling evidence that CO2 insufflation significantly reduces bloating and pain after routine colonoscopy in propofol-sedated patients. The procedure is safe with no significant differences in CO2 between the two groups.

  13. New and emerging therapies for the treatment of irritable bowel syndrome: an update for gastroenterologists

    OpenAIRE

    2016-01-01

    Irritable bowel syndrome is a functional bowel disorder with gastrointestinal symptoms (e.g. abdominal pain, straining, urgency, incomplete evacuation, nausea, and bloating) that occur alongside bowel function alterations (i.e. constipation, diarrhea, or both). Patients with irritable bowel syndrome may also experience comorbid anxiety and depression. Irritable bowel syndrome is common, with a prevalence estimated between 3% and 28%, affecting patient health and quality of life. Patients with...

  14. Intestinal myiasis caused by Muscina stabulans

    OpenAIRE

    Shivekar S; Senthil K; Srinivasan R; Sureshbabu L; Chand P; Shanmugam J; Gopal R.

    2008-01-01

    Intestinal maggots were isolated from a patient, who had reported to the Department of General Medicine of Sri Manakula Vinayagar Medical College, Puducherry, in southern India with complaints of abdominal distress, bloating of abdomen and intestinal hurry following a meal. He was diagnosed as a case of intestinal myiasis. Maggots obtained from his stool were identified to be Muscina stabulans based on characteristic patterns of posterior spiracles. He was treated with purgatives and albend...

  15. Cisplatin-induced peptic ulcers, vagotomy, adrenal and calcium modulation.

    Science.gov (United States)

    Aggarwal, S K; San Antonio, J D; Sokhansanj, A; Miller, C

    1994-04-01

    Cytochemical and autoradiographic studies in Wistar rats [Crl:(WI)BR] show that cisplatin treatment (9 mg/kg) inhibits the release of acetylcholine from the axonal endings of the stomach smooth muscle resulting in bloating of the stomach and ulceration. Cisplatin also induces corticosteroid release from the adrenal gland stimulating peptic ulceration. Vagotomy helps ameliorate the effect but not eliminate it. Calcium supplementation restores normal neuromuscular function to gastric smooth muscle, thereby eliminating the gastro-intestinal toxicity due to cisplatin.

  16. The Expanding Universe: Dark Energy

    Science.gov (United States)

    Lincoln, Don; Nord, Brian

    2014-01-01

    As is true of a far more famous story, it all began a long time ago, in a galaxy far, far away. It even involved a binary star system. A small star, called a white dwarf, had become a burned out husk of its former self and it turned to gorging on hydrogen and helium from its bloated red giant neighbor. The transferred gas reignited the fires of…

  17. Gambaran Pengetahuan dan Sikap ibu Tentang Gizi Seimbang dan Pola Makan Anak Autis di sdlbn 107708 Lubuk pakam tahun 2012

    OpenAIRE

    Ekawaty, Eva Erna

    2014-01-01

    Feeding patterns in children with autism should be possible, if the diet is not appropriate given it will be bad for the nutrients that can cause symptoms such as diarrhea, constipation, abdominal pain, gas, and bloating. This study is a descriptive survey research to describe the Mother of Knowledge and Attitude Balanced Nutrition and Diet Autistic Children in SDLBN Lubukpakam 107 708 in the District. The population in this study adalahseluruh mothers whose children have au...

  18. ECOLOGICAL SUCCESSION PATTERN OF THE INSECT SPECIES ASSOCIATED WITH THE CARCASS OF THE FREE-RANGING URBAN DOG, Canis domesticus (L.: A TOOL FOR FORENSIC ENTOMOLOGY

    Directory of Open Access Journals (Sweden)

    FARZANA PERVEEN

    2013-01-01

    Full Text Available The free-ranging urban dog, Canis domesticus (L. carcass decomposition in tropical region, i.e., Takht-i-Bahi, Mardan, Khyber Pakhtunkhwa, Pakistan during 15-25 May 2011 was characterized by 5 stages, i.e., fresh (12 h, bloated (13-48 h, active (49-96 h, advanced (97-144 h and dry (145-265 h and the ecological succession pattern of insect species collected were identified into 11 species of 3 orders. The insect species associated with the carcass of C. domesticus found that the blow flies, Chrysomya rufifacies (Macquart and house fly, Musca domestica (Linnaeus, 1758 were found in the fresh, bloat and active decay stages. However, the blow fly, C. megacephala (Fabricius; flesh fly, Parasarcophaga ruficornis (Meigen and the hornet wasp, Vespa orientalis (Linnaeus were existed in the fresh and bloat stages. Moreover, cheese fly, Piophila casei (Linnaeus was found bloat and active decay stages. Further, the hide beetle, Dermestes maculates (Geer, clown beetle, Hister sp. (Gullenhal; ham beetle, Necrobia rufipes (Fabricus and skin beetle, Trox sp. (Harold completed their life cycle in active decay, advance decay and dry stages. Furthermore, the jummper ant, Myrmecia pilosula (Smith was collected from only fresh stage. The specimens of insect species were collected minimum 0.8% of V. orientalis and maximum 21.3% of 2 species, i.e., C. rufifacies and M. domestica. The temperature, humidity and rainfalls were found affected insect larvae, pupae and adults, and rate of decomposition of C. domesticus. The average temperature, humidity and rainfalls were 35.34±1.54, 38.8% and 3.8 mm, respectively, of 11 experimental days. This research will be helpful for forensic entomologist for a case study of death to investigate of crimes in tropical region of Pakistan.

  19. [Obstruction of the nasal passage caused by a balloon catheter in a calf].

    Science.gov (United States)

    Rijkenhuizen, A B

    1993-01-01

    Decompression of the rumen as a supporting symptomatic therapy of recurrent bloat in calves and juvenile cattle is used regularly. The gas should be released for several days. This is facilitated by the use of a balloon stomach tube, which can be left in situ for up to five days. However, the use of this tube is not always without risks, which will be discussed on base of a patient.

  20. Diet and effects of diet management on symptoms and quality of life in patients with irritable bowel syndrome

    OpenAIRE

    Østgaard, Hege

    2011-01-01

    Background: Irritable bowel syndrome (IBS) is a gastrointestinal disorder manifested by abdominal discomfort or pain, bloating and abdominal distension, and changes in the defecation pattern between diarrhoea and constipation. A significant proportion of IBS patients attribute their symptoms to food items and food intolerance. More information is needed on the effect of diet management in the treatment of IBS and this thesis is a contribution with effort to adva...

  1. To Nissen or not to Nissen.

    Science.gov (United States)

    Schärli, A F

    1985-01-01

    Nissen's fundoplication is associated with a high morbidity rate in children. The symptoms are expressed as dysphagia, bloating, diarrhea, and neurotic behavioral changes. On the basis of our own experience, Nissen's fundoplication is not the treatment of choice in children. It is indicated only in cases where a total absence of reflux is tolerable (reflux followed by episodes of apnea, children with cerebral damage, etc.).

  2. Glucagon-like peptides 1 and 2

    DEFF Research Database (Denmark)

    Kissow, Hannelouise

    2015-01-01

    PURPOSE OF REVIEW: Chemotherapy often causes adverse effects, including pain, bloating, diarrhea, and inflammation and ulceration of the mucous membranes lining the digestive tract, which are collectively referred to as mucositis. Unfortunately, no remedy has been found yet to manage these side...... for therapeutic use. In type 2 diabetic and obese patients, GLP secretion is impaired. Elucidating the role of these endogenous hormones could lead to the identification of mucositis risk factors and an alternative preventive therapy for these patients....

  3. Current and Novel Therapeutic Options for Irritable Bowel Syndrome Management

    OpenAIRE

    2009-01-01

    Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder affecting up to 3-15% of the general population in western countries. It is characterized by unexplained abdominal pain, discomfort, and bloating in association with altered bowel habits. The pathophysiology of IBS is multifactorial involving disturbances of the brain-gut-axis. The pathophysiology provides the rationale for pharmacotherapy: abnormal gastrointestinal motor functions, visceral hypersensitivity, psychosocia...

  4. Review of Dercum’s disease and proposal of diagnostic criteria, diagnostic methods, classification and management

    OpenAIRE

    Hansson Emma; Svensson Henry; Brorson Håkan

    2012-01-01

    Abstract Definition and clinical picture We propose the minimal definition of Dercum’s disease to be generalised overweight or obesity in combination with painful adipose tissue. The associated symptoms in Dercum’s disease include fatty deposits, easy bruisability, sleep disturbances, impaired memory, depression, difficulty concentrating, anxiety, rapid heartbeat, shortness of breath, diabetes, bloating, constipation, fatigue, weakness and joint aches. Classification We suggest that Dercum’s ...

  5. Intestinal gas content and distribution in health and in patients with functional gut symptoms

    OpenAIRE

    Bendezú, Álvaro; Barba, Elisabeth; Burri, Emanuel; Cisternas, Daniel; Malagelada Prats, Carolina; Segui, Santi; Accarino Garaventa, Anna María; Quiroga, Sergi; Monclús Lahoya, Eva; Navazo Álvaro, Isabel; Malagelada Benapres, Juan Ramon; Azpiroz Vidaur, Fernando

    2015-01-01

    Background: The precise relation of intestinal gas to symptoms, particularly abdominal bloating and distension remains incompletely elucidated. Our aim was to define the normal values of intestinal gas volume and distribution and to identify abnormalities in relation to functional-type symptoms. Methods:Abdominal computed tomography scans were evaluated in healthy subjects (n = 37) and in patients in three conditions: basal (when they were feeling well; n = 88), during an episode of abdomi...

  6. The effect of abdominal massage in reducing malignant ascites symptoms.

    Science.gov (United States)

    Wang, Tsae-Jyy; Wang, Hung-Ming; Yang, Tsai-Sheng; Jane, Sui-Whi; Huang, Tse-Hung; Wang, Chao-Hui; Lin, Yi-Hsin

    2015-02-01

    As many as 50% of end-stage cancer patients will develop ascites and associated symptoms, including pain, tiredness, nausea, depression, anxiety, drowsiness, loss of appetite, dyspnea, perceived abdominal bloating, and immobility. Abdominal massage may stimulate lymph return to the venous system and reduce ascites-related symptoms. The purpose of this study was to test the effect of abdominal massage in reducing these symptoms and reducing ascites itself as reflected in body weight. For a randomized controlled design using repeated measures, a sample of 80 patients with malignant ascites was recruited from gastroenterology and oncology units of a medical center in northern Taiwan and randomly assigned to the intervention or the control group. A 15-minute gentle abdominal massage, using straight rubbing, point rubbing, and kneading, was administered twice daily for 3 days. The control group received a twice-daily 15-minute social interaction contact with the same nurse. Symptoms and body weight were measured in the morning for 4 consecutive days from pre- to post-test. In generalized estimation equation modeling, a significant group-by-time interaction on depression, anxiety, poor wellbeing, and perceived abdominal bloating, indicated that abdominal massage improved these four symptoms, with the greatest effect on perceived bloating. The intervention had no effect on pain, tiredness, nausea, drowsiness, poor appetite, shortness of breath, mobility limitation, or body weight. Abdominal massage appears useful for managing selected symptoms of malignant ascites.

  7. The impact of laxative use upon symptoms in patients with proven slow transit constipation

    Directory of Open Access Journals (Sweden)

    Dinning Phil G

    2011-11-01

    Full Text Available Abstract Background Constipation severity is often defined by symptoms including feelings of complete evacuation, straining, stool frequency and consistency. These descriptors are mostly obtained in the absence of laxative use. For many constipated patients laxative usage is ubiquitous and long standing. Our aim was to determine the impact of laxative use upon the stereotypic constipation descriptors. Methods Patients with confirmed slow transit constipation completed 3-week stool diaries, detailing stool frequency and form, straining, laxative use and pain and bloating scores. Each diary day was classified as being under laxative affect (laxative affected days or not (laxative unaffected days. Unconditional logistic regression was used to assess the affects of laxatives on constipation symptoms. Results Ninety four patients with scintigraphically confirmed slow transit constipation were enrolled in the study. These patients reported a stool frequency of 5.6 ± 4.3 bowel motions/week, only 21 patients reported P P Conclusions The reporting of frequent and loose stools with abdominal pain and/or bloating is common in patients with slow transit constipation. While laxative use is a significant contributor to altering stool frequency and form, laxatives have no apparent affect on pain or bloating or upon a patients feeling of complete evacuation. These factors need to be taken into account when using constipation symptoms to define this population.

  8. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome

    Institute of Scientific and Technical Information of China (English)

    Philippe Ducrotté; Prabha Sawant; Venkataraman Jayanthi

    2012-01-01

    AIM:To assess the symptomatic efficacy of Lactobacillus plantarum 299v (L.plantarum 299v) (DSM 9843) for the relief of abdominal symptoms in a large subset of irritable bowel syndrome (IBS) patients fulfilling the Rome Ⅲ criteria.METHODS:In this double blind,placebo-controlled,parallel-designed study,subjects were randomized to daily receive either one capsule of L.plantarum 299v (DSM 9843) or placebo for 4 wk.Frequency and intensity of abdominal pain,bloating and feeling of incomplete rectal emptying were assessed weekly on a visual analogue scale while stool frequency was calculated.RESULTS:Two hundred and fourteen IBS patients were recruited.After 4 wk,both pain severity (0.68+ 0.53 vs 0.92 + 0.57,P < 0.05) and daily frequency (1.01 + 0.77 vs 1.71 + 0.93,P < 0.05) were lower with L.plantarum 299v (DSM 9843) than with placebo.Similar results were obtained for bloating.At week 4,78.1% of the patients scored the L.plantarum 299v (DSM 9843) symptomatic effect as excellent or good vs only 8.1% for placebo (P < 0.01).CONCLUSION:A 4-wk treatment with L.plantarum 299v (DSM 9843) provided effective symptom relief,particularly of abdominal pain and bloating,in IBS patients fulfilling the Rome Ⅲ criteria.

  9. Calcium polycarbophil compared with placebo in irritable bowel syndrome.

    Science.gov (United States)

    Toskes, P P; Connery, K L; Ritchey, T W

    1993-02-01

    Calcium polycarbophil was compared with placebo in 23 patients with irritable bowel syndrome in a six-month, randomized double-blind crossover study. Patients received polycarbophil tablets at a dosage of 6 g/day (twelve 0.5-g tablets) or matching placebo tablets. At study end, among patients expressing a preference, 15 of 21 (71%) chose polycarbophil over placebo for relief of the symptoms of irritable bowel syndrome. Statistically significant differences favouring polycarbophil were found among the following patient subgroups: 15 (79%) of 19 with constipation: all six with alternating diarrhoea and constipation; 13 (87%) of 15 with bloating: and 11 (92%) of 12 with two or more symptoms. Polycarbophil was rated better than placebo in monthly global responses to therapy. Patient diary entries showed statistically significant improvement for ease of passage with polycarbophil. Polycarbophil was rated better than placebo for relief of nausea, pain, and bloating. The data suggest that calcium polycarbophil can benefit irritable bowel syndrome patients with constipation or alternating diarrhoea and constipation and may be particularly useful in patients with bloating as a major complaint.

  10. Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease

    Institute of Scientific and Technical Information of China (English)

    Vikas G Pai; Nitin V Pai; Hemant P Thacker; Jaisingh K Shinde; Vijay P Mandora; Subhash S Erram

    2006-01-01

    AIM: To compare the efficacy and tolerability of S-pantoprazole (20 mg once a day) versus racemic Pantoprazole (40 mg once a day) in the treatment of gastroesophageal reflux disease (GERD).METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suffering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28.RESULTS: Significant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001)and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically significant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the reference group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no significant difference in healing of esophagitis (P= 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation,bloating and equally

  11. 寒区军人功能性肠病的调查报告%Epidemiological investigation of functional intestinal disorders in Chinese soldiers under severe cold condition

    Institute of Scientific and Technical Information of China (English)

    刘旭; 郭晓钟; 李宏宇; 赵佳钧

    2015-01-01

    Objective To investigate the incidence of functional intestinal disorders( FID) among the soldiers under severe cold condi-tion and contribute to the precention of medical support. Methods According to cluster sampling,650 soldiers stationed in latitude 45°to 50°garrison were recruited. The standard questionnaire of RomeⅢ,Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used. Results Totally 622 valid questionnaires were returned. The incidence of FID was 29. 9%,which includes ir-ritable bowel syndrome was 10. 1%(63 cases),functional bloating was 5. 3%(33 cases),functional constipation was 6. 1%(38 ca-ses),functional diarrhea was 4. 5%(28 cases),nonspecific bowel dysfunction was 3. 8%(24 cases). Bloating,constipation,diarrhea were the most frequent symptoms. Under -20℃,the number of the soldiers suffered bloating and diarrhea was significantly increased than under -10℃,and-20℃(P40分者分别占13.4%和54.3%,高于非 FID 组官兵的6.65%和41.1%,差异有统计学意义(P <0.05)。结论寒区官兵FID发病率较高,以肠易激综合征最常见。腹痛、腹胀等功能性肠病的常见症状随温度的降低,发生率升高。寒冷诱发的FID对官兵有明显的心理影响。因此,现有的卫勤保障措施对寒区官兵FID的防治仍有待改善。

  12. Hernia of Morgagni--case report.

    Science.gov (United States)

    Zadro, Zvonko; Frketić, Ivan; Boban, Zdenko; Zadro, Ana Sostarić; Fudurić, Jurica; Veir, Zoran; Jurjević, Zoran

    2012-12-01

    Morgagni's hernia is result of penetration of the abdominal contents into the chest through an anterior retrocostoxiphoid defect in the anterior midline of the diaphragm. It can be manifested with symptoms since birth as a bloated feeling, nausea and belching after meals. We present a patient with symptomatic herniation of the torqued antral part of stomach and loops of the transverse colon. In our case, chest and abdominal radiography after oral intake of contrast are used to diagnose this condition. Herniation was reduced surgically by a transabdominal approach. At the control examination one year after surgery in our patient all symptoms have disappeared, and was given 15 kg of body weight.

  13. The clinical consequences of sucrase-isomaltase deficiency.

    Science.gov (United States)

    Cohen, Stanley A

    2016-12-01

    Primary sucrase-isomaltase deficiency, originally thought to be a homozygous recessive disorder, has been found to have numerous genetic variants that alone or in combination (compound heterozygosity) express varying degrees of clinical illness, most commonly causing chronic diarrhea, abdominal pain, and bloating. These symptoms are also present with secondary sucrase-isomaltase deficiency. Recent investigations are providing evidence that sucrase-isomaltase deficiency is more prevalent and of greater clinical significance than previously suspected. Further research is required to correlate the specific genotypes and phenotypes with their clinical expressions and to determine the most appropriate treatment algorithm for these patients.

  14. Android quick APIs reference

    CERN Document Server

    Cinar, Onur

    2015-01-01

    The Android Quick APIs Reference is a condensed code and APIs reference for the new Google Android 5.0 SDK. It presents the essential Android APIs in a well-organized format that can be used as a handy reference. You won't find any technical jargon, bloated samples, drawn out history lessons, or witty stories in this book. What you will find is a software development kit and APIs reference that is concise, to the point and highly accessible. The book is packed with useful information and is a must-have for any mobile or Android app developer or programmer. In the Android Quick APIs Refe

  15. [How I EXPLORE ... SIGMOID VOLVULUS].

    Science.gov (United States)

    Dequiedt, C; Milicevic, M

    2016-05-01

    Sigmoid volvulus is a significant cause of bowel obstruction and will become a major cause in the future given its prevalence in the elderly and/or institutionalized patients. Furthermore that's the first cause of bowel obstruction in pregnant women. Given it's a non specific clinical presentation, the clinician has to do complementary exams, above all the x ray examinations. So, the role of radiologist is primordial in diagnostic, sometimes in the treatment given important morbidity and mortality of this pathology. We bring you here a typical case of sigmoid volvulus in 60 years old patient seen in emergency department for bloating and vomiting since several days.

  16. Utilisation of different types of coal fly ash in the production of ceramic tiles

    Energy Technology Data Exchange (ETDEWEB)

    Kockal, N. U.

    2012-11-01

    The influence of varying proportions of different types of fly ash (used in place of feldspar) and different sintering temperatures on the sintered properties of ceramic tile bodies was evaluated. The results indicated that sintering ceramic tiles with a high fly ash content at a high temperature caused a decrease in the properties because of bloating. The ceramic samples containing a higher amount of fly ash that were sintered at low temperature exhibited lower water absorption, larger shrinkage and strength because of the densification observed also in microstructural investigation. (Author) 25 refs.

  17. Intestinal myiasis caused by Muscina stabulans.

    Science.gov (United States)

    Shivekar, S; Senthil, K; Srinivasan, R; Sureshbabu, L; Chand, P; Shanmugam, J; Gopal, R

    2008-01-01

    Intestinal maggots were isolated from a patient, who had reported to the Department of General Medicine of Sri Manakula Vinayagar Medical College, Puducherry, in southern India with complaints of abdominal distress, bloating of abdomen and intestinal hurry following a meal. He was diagnosed as a case of intestinal myiasis. Maggots obtained from his stool were identified to be Muscina stabulans based on characteristic patterns of posterior spiracles. He was treated with purgatives and albendazole. This intestinal myiasis case caused by M. stabulans is reported here because of its rare occurrence and the need to establish a correct diagnosis.

  18. Intestinal myiasis caused by Muscina stabulans

    Directory of Open Access Journals (Sweden)

    Shivekar S

    2008-01-01

    Full Text Available Intestinal maggots were isolated from a patient, who had reported to the Department of General Medicine of Sri Manakula Vinayagar Medical College, Puducherry, in southern India with complaints of abdominal distress, bloating of abdomen and intestinal hurry following a meal. He was diagnosed as a case of intestinal myiasis. Maggots obtained from his stool were identified to be Muscina stabulans based on characteristic patterns of posterior spiracles. He was treated with purgatives and albendazole. This intestinal myiasis case caused by M. stabulans is reported here because of its rare occurrence and the need to establish a correct diagnosis.

  19. Short Term (14 Days) Consumption of Insoluble Wheat Bran Fibre-Containing Breakfast Cereals Improves Subjective Digestive Feelings, General Wellbeing and Bowel Function in a Dose Dependent Manner

    OpenAIRE

    Lawton, Clare; Walton, Jenny; Hoyland, Alexa; Howarth, Elaine; Allan, Peter; Chesters, David; Dye, Louise

    2013-01-01

    15 g/day AOAC 985.29) completed a daily symptom diary for 14 days after which they consumed one bowl of ready-to-eat breakfast cereal containing at least 5.4 g fibre (3.5 g from wheat bran) for 14 days and completed a daily symptom diary. Significant improvements were demonstrated in subjective perception of bowel function (e.g., ease of defecation) and digestive feelings (bloating, constipation, feeling sluggish and digestive discomfort). Significant improvements were also found in subjectiv...

  20. Current perspectives on the management of gastroparesis

    Directory of Open Access Journals (Sweden)

    Rattansingh A

    2005-01-01

    Full Text Available Gastroparesis is a condition of abnormal gastric motility characterised by delayed gastric emptying in the absence of mechanical outlet obstruction. It is seen commonly in people with diabetes but is idiopathic in a third of patients. Symptoms include nausea and vomiting, post-prandial fullness and early satiety, and abdominal bloating and discomfort. Investigations fall into three categories: gastric emptying studies, intraluminal pressure measurements and recording of gastric myoelectrical activity. Nuclear scintigraphy is considered the gold standard for diagnosing and quantifying delayed gastric emptying. Treatment options include diet and behavioural changes, prokinetic drugs and surgical interventions. New advances in drug therapy and gastric electrical stimulation techniques hold considerable promise.

  1. A Case of Multicentric Carcinoid in a Patient with Psoriatic Spondyloarthropathy

    Directory of Open Access Journals (Sweden)

    Nabil George

    2015-01-01

    Full Text Available We describe the first case of a patient presenting with multicentric carcinoid occurring in the lung and subsequently in the rectum, with chronic psoriatic arthritis. Although reports have been published regarding carcinoid syndrome occurring alongside rheumatoid arthritis, no reports have been made on such a case. Initial presentation of carcinoid syndrome in this patient was insidious and atypical with few symptoms, including shortness of breath and long standing abdominal bloating. Several years later a sudden change in bowel habit prompted a colonoscopy with biopsy that revealed a carcinoid rectal polyp. The case we report describes a rare presentation of carcinoid syndrome in chronic psoriatic arthropathy.

  2. Diverticular disease: A therapeutic overview

    Institute of Scientific and Technical Information of China (English)

    Antonio; Tursi

    2010-01-01

    Formation of colonic diverticula, via herniation of the colonic wall, is responsible for the development of diverticulosis. When diverticulosis becomes symptomatic, it becomes diverticular disease. Diverticular disease is common in Western and industrialized countries, and it is associated with numerous abdominal symptoms (including pain, bloating, nausea, diarrhea, and constipation). Standard medical therapies with antibiotics are currently recommended for patients affected by diverticular disease. However, changing concepts on the pathophysiology of the disease suggest that diverticular disease may share many of the hallmarks of inflammatory bowel diseases. On this basis, the addition of therapies using mesalazine and probiotics may enhance treatment eff icacy by shortening the course of the disease and preventing recurrences.

  3. [Mesenteric cyst in the Instituto Nacional de Salud del Niño, Lima, Peru: a case report].

    Science.gov (United States)

    Cucho, Janetliz; Ormeño, Alexis; Valdivieso Falcon, Lidia; Pereyra, Sonia; Ramos Rodríguez, Karen

    2013-01-01

    Mesenteric cysts are rare abdominal tumors. About 60% of these cysts occurs before 5 years of age and can be located anywhere in the gastrointestinal tract, but are most often found in the small bowel mesentery. The clinical presentation depends on the location and size of the cyst and many cases are asymptomatic and are diagnosed incidentally. The most common symptoms are abdominal pain, bloating, abdominal mass, nausea, vomiting, constipation, diarrhea, weight loss, fever and peritonitis. Complications include torsion, infarction, volvulus formation, perforation, infection, anemia, intracystic hemorrhage, intestinal obstruction and obstructive uropathy. They are typically treated by simple excision, marsupialization or segmental bowel resection and have excellent long-term prognosis.

  4. Initial study of arthropods succession and pig carrion decomposition in two freshwater ecosystems in the Colombian Andes.

    Science.gov (United States)

    Barrios, Maria; Wolff, Marta

    2011-10-10

    Entomological succession and trophic roles of arthropods associated with different stages of carcass decomposition were studied to estimate the post-mortem submersion interval in two freshwater ecosystems in the Colombian Andes, at an altitude of 2614 m. Pig carcasses were employed as models placed 68 m apart, one in a stream (lotic) and another in an artificial lake (lentic). Decomposition time to skeletal remains was 74 days in the lake and 80 days in the stream. Six phases of decomposition were established: submerged fresh, early floating, floating decay, bloated deterioration, floating remains and sunken remains. A total of 18,832 organisms associated with the carcasses were collected: 11,487 in the lake (four orders, 19 families and 33 species) and 7345 in the stream (eight orders, 15 families and 25 species). Organisms were classified in the following ecological categories: shredders, collectors, predators, necrophagous, sarcosaprophagous and opportunists. Physical and chemical properties of the habitats, such as water temperature, CO(2) and conductivity, varied according to rainfall. In the lake, shredders (Coleoptera: Tropisternus sp. and Berosus sp.) and collectors (Diptera: Chironomus sp.) were found to be associated with submerged phases. Predators (Odonata) were only present during the first phases. Coleoptera (Dytiscidae) were found during floating decay and bloated deterioration stages. In the stream, shredders (Hyalella sp.) and collectors (Simulium sp.) were found during all stages, whereas the predator Oxelytrum discicolle was found exclusively during the floating stages, during which body temperature increased in a fashion similar to active decay in terrestrial environments.

  5. The Role of Proanthocyanidins Complex in Structure and Nutrition Interaction in Alfalfa Forage.

    Science.gov (United States)

    Jonker, Arjan; Yu, Peiqiang

    2016-05-23

    Alfalfa (Medicago sativa L.) is one of the main forages grown in the world. Alfalfa is a winter hardy, drought tolerant, N-fixing legume with a good longevity, high yield, high nutrient levels, high digestibility, unique structural to non-structural components ratio, high dry matter intake, and high animal productivity per hectare. However, its main limitation is its excessively rapid initial rate of protein degradation in the rumen, which results in pasture bloat and inefficient use of protein with consequent excessive excretions of nitrogen into the environment. Proanthocyanidins are secondary plant metabolites that can bind with protein and thereby reduce the rate and extent of ruminal protein degradation. However, these secondary metabolites do not accumulate in alfalfa. This review aims to firstly describe the events involved in the rapid release of protein from alfalfa and its effect on ruminant nutrition, environmental pollution, and pasture bloat; secondly, to describe occurrence, structure, functions and benefits of moderate amounts of proanthocyanidin; and finally, to describe the development of alfalfa which accumulates moderate amounts of proanthocyanidins. The emphasis of this review focuses on the role of proanthocyanidins compounds in structure and nutrition interaction in ruminant livestock systems.

  6. Extending our knowledge of fermentable, short-chain carbohydrates for managing gastrointestinal symptoms.

    Science.gov (United States)

    Barrett, Jacqueline S

    2013-06-01

    The Monash University low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) diet is now accepted as an effective strategy for managing symptoms of irritable bowel syndrome (IBS) in Australia, with interest expanding across the world. These poorly absorbed, short-chain carbohydrates have been shown to induce IBS symptoms of diarrhea, bloating, abdominal pain, and flatus due to their poor absorption, osmotic activity, and rapid fermentation. Four clinical trials have been published to date, all with significant symptomatic response to the low FODMAP diet. Up to 86% of patients with IBS have achieved relief of overall gastrointestinal symptoms and, more specifically, bloating, flatus, abdominal pain, and altered bowel habit from the approach. This review provides an overview of the low FODMAP diet and summarizes the research to date, emerging concepts, and limitations. FODMAPs are known to be beneficial to bowel health; the importance of this and how this should be considered in the clinical management of IBS is also discussed. A clinical management flowchart is provided to assist nutrition professionals in the use of this approach.

  7. The Role of Proanthocyanidins Complex in Structure and Nutrition Interaction in Alfalfa Forage

    Directory of Open Access Journals (Sweden)

    Arjan Jonker

    2016-05-01

    Full Text Available Alfalfa (Medicago sativa L. is one of the main forages grown in the world. Alfalfa is a winter hardy, drought tolerant, N-fixing legume with a good longevity, high yield, high nutrient levels, high digestibility, unique structural to non-structural components ratio, high dry matter intake, and high animal productivity per hectare. However, its main limitation is its excessively rapid initial rate of protein degradation in the rumen, which results in pasture bloat and inefficient use of protein with consequent excessive excretions of nitrogen into the environment. Proanthocyanidins are secondary plant metabolites that can bind with protein and thereby reduce the rate and extent of ruminal protein degradation. However, these secondary metabolites do not accumulate in alfalfa. This review aims to firstly describe the events involved in the rapid release of protein from alfalfa and its effect on ruminant nutrition, environmental pollution, and pasture bloat; secondly, to describe occurrence, structure, functions and benefits of moderate amounts of proanthocyanidin; and finally, to describe the development of alfalfa which accumulates moderate amounts of proanthocyanidins. The emphasis of this review focuses on the role of proanthocyanidins compounds in structure and nutrition interaction in ruminant livestock systems.

  8. A pilot trial on subjects with lactose and/or oligosaccharides intolerance treated with a fixed mixture of pure and enteric-coated α- and β-galactosidase

    Science.gov (United States)

    Di Pierro, Francesco; Bertuccioli, Alexander; Marini, Eleonora; Ivaldi, Leandro

    2015-01-01

    Aim Lactose and complex carbohydrates maldigestion, common food intolerances due to low gut content of α- and β-galactosidase, lead to abdominal symptoms including pain, diarrhea, bloating, flatulence, and cramping. Commonly, intolerant patients are advised by physicians to avoid the offending foods (dairy foods, cereals, beans, etc). This food-limiting option, however, has possible nutritional risks. We have therefore evaluated the impact of using pure, enteric-coated α- plus β-galactosidase on gut symptoms in intolerant subjects instead of avoidance of the offending foods. Methods Sixteen subjects intolerant to lactose and/or complex carbohydrates were enrolled and evaluated in terms of gut symptoms with 1) uncontrolled diet, 2) diet devoid of offending foods, and 3) uncontrolled diet along with pure, enteric-coated α- and β-galactosidase (DDM Galactosidase®). Results Even with the uncontrolled diet, intolerant subjects treated with DDM Galactosidase® exhibited reduced gut symptoms (bloating, flatulence, diarrhea, and constipation) significantly better than the control treatment as well as having a diet devoid of offending foods. Conclusion DDM Galactosidase® is a valid and safe optional treatment to counteract lactose and complex carbohydrate intolerance in subjects who prefer not to avoid, at least partially, offending foods. PMID:25733920

  9. Pain relief by applying transcutaneous electrical nerve stimulation (TENS) during unsedated colonoscopy: a randomized double-blind placebo-controlled trial.

    Science.gov (United States)

    Amer-Cuenca, J J; Goicoechea, C; Girona-López, A; Andreu-Plaza, J L; Palao-Román, R; Martínez-Santa, G; Lisón, J F

    2011-01-01

    Transcutaneous electrical nerve stimulation (TENS) is a noninvasive alternative to traditional pain treatments. TENS has been studied in the past as a pain reduction modality in colonoscopy with limited success. Reviews and meta-analysis have shown that the inconclusive results of TENS may be due to the lack of randomized controlled trials and the difficulty in defining precise output parameters. The objective of this double-blind randomized placebo-controlled trial was to investigate the pain-relieving effect of a new application of TENS in unsedated screening colonoscopy. Ninety patients undergoing unsedated screening colonoscopy were randomly allocated to one of three groups: a control group (n=30), a group to receive active TENS (n=30), or a group to receive placebo TENS (n=30). A visual analogue scale (VAS) and a five-point Likert scale were used to assess pain 5 min into the procedure and at the end of the procedure. The patient's bloating sensation during colonoscopy and the effect on the duration of the procedure were also evaluated. Throughout the procedure, the active TENS group experienced a VAS pain score reduction ≥50% compared to the placebo TENS group (PTENS group compared to the placebo TENS and control groups (P=0.009). No significant differences were found between the study groups as to the bloating sensation and the duration of the procedure. We conclude that TENS can be used as a pain relief therapy in unsedated screening colonoscopy.

  10. Managing irritable bowel syndrome in primary care.

    Science.gov (United States)

    Corsetti, Maura; Whorwell, Peter J

    2015-06-01

    The classic symptoms of irritable bowel syndrome (IBS) are abdominal pain, bloating and some form of bowel dysfunction. The pain is typically colicky in nature and can occur at any site although most commonly it is on the left side. The abdomen feels flat in the morning and then gradually becomes more bloated as the day progresses reaching a peak by late afternoon or evening. It then subsides again over night. Traditionally IBS is divided into diarrhoea, constipation or alternating subtypes. IBS patients frequently complain of one or more non-colonic symptoms, these include constant lethargy, low backache, nausea, bladder symptoms suggestive of an irritable bladder, chest pain and dyspareunia in women. The traditional view that IBS is a largely psychological condition is no longer tenable. Rectal bleeding, a family history of malignancy and a short history in IBS should always be treated with suspicion. Both pain and bowel dysfunction are often made worse by eating. It is recommended that a coeliac screening test is undertaken to rule out this condition. Other routine tests should include inflammatory markers such as CRP or ESR. Calprotectin is a marker for leukocytes in the stools and detects gastrointestinal inflammation. A negative test almost certainly rules out inflammatory bowel disease, especially in conjunction with a normal CRP. Fermentable carbohydrates can have a detrimental effect on IBS and this has led to the introduction of the low FODMAP diet.

  11. Preliminary study of insects associated to indoor body decay in Colombia

    Directory of Open Access Journals (Sweden)

    Yardany Ramos-Pastrana

    2014-12-01

    Full Text Available Preliminary study of insects associated to indoor body decay in Colombia. This is the first report studying insects associated to indoor body decay process of a white pig (Sus scrofa (Artiodactyla, Suidae in a controlled indoor environment in an urban area of Florencia city, Amazonia Piedmont, Colombia. For a period of 54 days, 9,220 individuals (immature and adults, distributed in 3 orders, 5 families, 10 genera, and 10 species were collected using entomological nets and tweezers. Five decaying stages are described (fresh, bloated, active decay, advanced decay and remains. During the fresh stage we recorded Cochliomyia macellaria (Fabricius, 1775, Chrysomya albiceps (Wiedemann, 1819, Ophyra aenescens (Wiedemann, 1830, Oxysarcodexia sp., Lepidodexia sp. and Lasiophanes sp.; during the bloating stage C. macellaria, C. albiceps, Lucilia eximia (Wiedemann, 1819, Hemilucillia semidiaphana (Rondani, 1850, Musca domestica Linnaeus, 1758, O. aenescens, Oxysarcodexia sp., Lepidodexia sp., Dermestes maculatus De Geer, 1774 and Lasiphanes sp.; during the active decay C. macellaria, C. albiceps, L. eximia, M. domestica, O. aenescens, Lepidodexia sp. D. maculatus and Lasiophanes sp.; during the advanced decay C. macellaria, C. albiceps, M. domestica, Lepidodexia sp. and Lasiophanes sp.; and during the remains stage C. albiceps, D. maculatus and Lasiophanes sp. The insects were sorted out in 3 ecological categories; necrophagous, predators and parasites and sarco-saprophagous. According to Chao and Jack estimators, total richness was observed on day 20, with 100% of the expected species.

  12. Recycling of air pollution control residues from municipal solid waste incineration into lightweight aggregates.

    Science.gov (United States)

    Quina, Margarida J; Bordado, João M; Quinta-Ferreira, Rosa M

    2014-02-01

    This work focuses on the assessment of technological properties and on the leaching behavior of lightweight aggregates (LWA) produced by incorporating different quantities of air pollution control (APC) residues from municipal solid waste (MSW) incineration. Currently this hazardous waste has been mostly landfilled after stabilization/solidification. The LWA were produced by pelletizing natural clay, APC residues as-received from incineration plant, or after a washing treatment, a small amount of oil and water. The pellets were fired in a laboratory chamber furnace over calcium carbonate. The main technological properties of the LWA were evaluated, mainly concerning morphology, bulk and particle densities, compressive strength, bloating index, water adsorption and porosity. Given that APC residues do not own expansive (bloating) properties, the incorporation into LWA is only possible in moderate quantities, such as 3% as received or 5% after pre-washing treatment. The leaching behavior of heavy metals from sintered LWA using water or acid solutions was investigated, and despite the low acid neutralization capacity of the synthetic aggregates, the released quantities were low over a wide pH range. In conclusion, after a washing pre-treatment and if the percentage of incorporation is low, these residues may be incorporated into LWA. However, the recycling of APC residues from MSW incineration into LWA does not revealed any technical advantage.

  13. Seasonality of insect succession on exposed rabbit carrion in Guangzhou,China

    Institute of Scientific and Technical Information of China (English)

    Yan-Wei Shi; Xiao-Shan Liu; Hai-Yang Wang; Run-Jie Zhang

    2009-01-01

    Succession patterns for insect fauna,spanning four seasons,on rabbit carcasses were studied in Guangzhou China from 2006 to 2008.A total of 49 taxa belonging to three orders and 15 families were collected and identified.Four decomposition stages were recognized:fresh,bloated,decay and dry stage.Taxa diversity was higher in bloated and decay stages than fresh and dry stages.Internal and ambient temperatures were measured.Maximum internal temperature arrived earlier in warmer seasons.The sequence of insect succession in this study follows the same general patterns:the Diptera peaked initially,and the Coleoptera peaked later.Chrysomya megacephala was the dominant species in four seasons.Its time point of different development stages on carrion could be the most important indicators for PMI (postmaortem interval) estimation in Guangzhou.Yearly and seasonal differences in activities of insects were compared.Alpha diversity indices were calculated.There were no significant differences in Shannon-Wiener index,evenness (J) and dominance (C) between seasons and years.From the Jaccard similarity index,the highest similarity was between winter and spring,while the lowest was between summer and winter.Some species occurring exclusively in one season may be important to characterize different seasons.A list of the insect taxa associated with above-ground rabbit carrion during the four seasons was compiled,which can be used for estimating time since death in similar bio-climate areas.

  14. Post-prandial reactive hypoglycaemia and diarrhea caused by idiopathic accelerated gastric emptying: a case report

    Directory of Open Access Journals (Sweden)

    Balan Kottekkattu

    2011-05-01

    Full Text Available Abstract Introduction The majority of cases of post-prandial reactive hypoglycemia are considered idiopathic. Abnormalities of B-cell function and glucose regulation by insulin and glucagon have been postulated as causes but associated gastrointestinal dysfunction has not been reported. We report the first case of accelerated gastric emptying associated with post-prandial reactive hypoglycemia, abdominal bloating and diarrhea. We consider that gastric dysmotility is an important cause of this condition as treatment of the underlying abnormal gastric emptying allows effective control of symptoms. Case presentation A 20-year-old Caucasian woman presented with post-prandial fatigue, sweating, nausea, faintness and intermittent confusion, which had led to pre-syncope and syncope on occasions. She also experienced marked abdominal bloating and diarrhea over the same period. These episodes responded to oral administration of sweet drinks. Her symptoms were ameliorated by modification of her diet. Conclusion This is an original case report of the association of idiopathic accelerated gastric emptying with post-prandial reactive hypoglycemia and diarrhea. Family physicians, endocrinologists and gastroenterologists often consult patients with a constellation of post-prandial symptoms, which are considered to be idiopathic in most cases. This case indicates that gastric dysmotility might be the primary cause of these symptoms in some patients and, if found, offers a therapeutic target which in our case was successful.

  15. Carbon dioxide insufflation during colonoscopy in deeply sedated patients

    Institute of Scientific and Technical Information of China (English)

    Rajvinder Singh; Eu Nice Neo; Nazree Nordeen; Ganesananthan Shanmuganathan; Angelie Ashby; Sharon Drummond; Garry Nind

    2012-01-01

    AIM:To compare the impact of carbon dioxide (CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the procedure.Both the colonoscopist and patient were blinded to the type of gas used.During the procedure,insertion and withdrawal times,caecal intubation rates,total sedation given and capnography readings were recorded.The level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale (VAS) (0-3).Patients then graded their level of discomfort and abdominal bloating using a similar VAS.Complications during and after the procedure were recorded.RESULTS:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 arm.Mean age between the two study groups were similar.Insertion time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air (P =0.0083).The average withdrawal times were not significantly different between the two groups.Caecal intubation rates were 94.4% and 100% in the air and CO2 groups respectively (P =0.012).The level of discomfort assessed by the nurse was 0.69 (air) and 0.39 (CO2) (P =0.0155) and by the patient 0.82 (air) and 0.46 (CO2) (P =0.0228).The level of abdominal bloating was 0.97 (air) and 0.36 (CO2) (P =0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air insufflation.There were no complications in both arms.CONCLUSION:CO2 insuffiation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation rates.Abdominal discomfort and bloating were significantly less with CO2 insufflation.

  16. 剖宫产产妇术后循证护理的临床效果分析%Clinical effects of evidence-based care for cesarean section puerperae

    Institute of Scientific and Technical Information of China (English)

    张丽梅

    2013-01-01

    Objective To analyze the clinical effects of evidence-based care for cesarean section puerperae. Methods The cesarean section puerperae's clinical datum from January 2010 -February 2013 were retrospectively analyzed. 100 puerperae with general care were selected from January 2010 - January 2012 as control group,100 puerperae with general care and evidence-based care were selected from February 2012-February 2013 as observation group. Compared maternal constipation、intestinal function recovery time and bloating and other aspects of the two groups. Results Maternal constipation,intestinal function recovery time and bloating and other aspects of the observation group were significantly better than the control group(P<0.05). Conclusion Evidence-based care make puerperae smooth recovery after cesarean section,reduce bloating,constipation and other occurrence probability,it can improve maternal and neonatal quality of life,it's worthy of promotion.%目的分析剖宫产产妇术后应用循证护理的临床效果。方法对我院2010年1月~2013年2月收治的剖宫产产妇的临床资料进行回顾性分析,在2010年1月~2012年1月采用一般护理的剖宫产产妇中选取100例作为对照组,在2012年2月~2013年2月在常规护理基础上增加循证护理模式的剖宫产产妇中选取100例作为观察组。比较两组产妇便秘、肠功能恢复时间和腹胀方面等情况。结果观察组产妇在便秘、肠功能恢复时间和腹胀等方面均明显优于对照组(P<0.05),两组比较差异有统计学意义。结论循证护理能够使产妇在剖宫产后顺利恢复,降低腹胀、便秘等发生机率,提高产妇和新生儿的生活质量,值得临床推广。

  17. Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract

    Institute of Scientific and Technical Information of China (English)

    Kenneth Brown; Brandi Scott-Hoy; Linda W Jennings

    2016-01-01

    The aim of this case series was to retrospectively examine the symptom response of irritable bowel syndrome with constipation(IBS-C) patients administered an herbal extract in a real-world setting. Twenty-four IBS-C patients in a community office practice were provided a combination over-the-counter dietary supplement composed of quebracho(150 mg), conker tree(470 mg) and M. balsamea Willd(0.2 mL) extracts(Atrantil?) and chose to take the formulation for a minimum of 2 wk in an attempt to manage their symptoms. Patient responses to the supplement were assessed by visual analogue scale(VAS) for abdominal pain, constipation and bloating at baseline and at 2 wk as part of standard-of-care. Patient scores from VAS assessments recorded in medical chart data were retrospectively compiled and assessed for the effects of the combined extract on symptoms. Sign tests were used to compare changes from baseline to 2 wk of taking the extract. Significance was defined as P < 0.05. Twenty-one of 24 patients(88%) responded to the dietary supplement as measured by individual improvements in VAS scores for abdominal pain, bloating and constipation symptoms comparing scores prior to administration of the extract against those reported after 2 wk. There were also significant improvements in individual as well as mean VAS scores after 2 wk of administration of the combinedextract compared to baseline for abdominal pain [8.0(6.5, 9.0) vs 2.0(1.0, 3.0), P < 0.001], bloating [8.0(7.0, 9.0) vs 1.0(1.0, 2.0), P < 0.001] and constipation [6.0(3.0, 8.0) vs 2.0(1.0, 3.0), P < 0.001], respectively. In addition, 21 of 24 patients expressed improved quality of life while taking the formulation. There were no reported side effects to administration of the dietary supplement in this practice population suggesting excellent tolerance of the formulation. This pilot retrospective analysis of symptom scores from patients before and after consuming a quebracho/conker tree/M. balsamea Wil d extract may

  18. Forensic entomology of decomposing humans and their decomposing pets.

    Science.gov (United States)

    Sanford, Michelle R

    2015-02-01

    Domestic pets are commonly found in the homes of decedents whose deaths are investigated by a medical examiner or coroner. When these pets become trapped with a decomposing decedent they may resort to feeding on the body or succumb to starvation and/or dehydration and begin to decompose as well. In this case report photographic documentation of cases involving pets and decedents were examined from 2009 through the beginning of 2014. This photo review indicated that in many cases the pets were cats and dogs that were trapped with the decedent, died and were discovered in a moderate (bloat to active decay) state of decomposition. In addition three cases involving decomposing humans and their decomposing pets are described as they were processed for time of insect colonization by forensic entomological approach. Differences in timing and species colonizing the human and animal bodies were noted as was the potential for the human or animal derived specimens to contaminate one another at the scene.

  19. AdSplit: Separating smartphone advertising from applications

    CERN Document Server

    Shekhar, Shashi; Wallach, Dan S

    2012-01-01

    A wide variety of smartphone applications today rely on third-party advertising services, which provide libraries that are linked into the hosting application. This situation is undesirable for both the application author and the advertiser. Advertising libraries require additional permissions, resulting in additional permission requests to users. Likewise, a malicious application could simulate the behavior of the advertising library, forging the user's interaction and effectively stealing money from the advertiser. This paper describes AdSplit, where we extended Android to allow an application and its advertising to run as separate processes, under separate user-ids, eliminating the need for applications to request permissions on behalf of their advertising libraries. We also leverage mechanisms from Quire to allow the remote server to validate the authenticity of client-side behavior. In this paper, we quantify the degree of permission bloat caused by advertising, with a study of thousands of downloaded ap...

  20. Could kinesiology taping help mitigate pain, breathlessness and abdominal-related symptoms in cancer?

    Science.gov (United States)

    Banerjee, Gourav; Rose, Alison; Briggs, Michelle; Johnson, Mark I

    2017-01-01

    We present the case of a woman who was an amateur athlete diagnosed with primary breast cancer, and 10 years later with terminal metastatic cancer. This case report was prepared posthumously in co-operation with her next of kin (husband). The patient first presented to a sports physiotherapist (AR) for her pain-management and to help maintain physical fitness so that she could continue with sports and an active lifestyle. The patient continued with physiotherapy for several months to enable her to be active. However, when her health deteriorated significantly due to advancing cancer, the treatment was modified and aimed at improving the patient's general well-being. The physiotherapist applied kinesiology tape over the patient's lower rib cage, diaphragm and abdomen in an attempt to manage pain, breathlessness and abdominal bloating. The patient reported alleviation of pain, breathlessness, abdominal discomfort and nausea, accompanied by improvements in eating, drinking, energy levels and physical function. PMID:28237944

  1. [Importance of diet in irritable bowel syndrome].

    Science.gov (United States)

    Mearin, Fermín; Peña, Enrique; Balboa, Agustín

    2014-05-01

    About two-thirds of irritable bowel syndrome (IBS) patients associate their symptoms with certain foods. We reviewed food-related factors putatively associated with manifestations of IBS. Soluble fiber may improve constipation but frequently increases bloating and abdominal pain. Carbohydrate malabsorption seems to be more frequent in IBS. A low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diet significantly reduces IBS symptoms and has been suggested as a therapeutic option. Serological screening for celiac disease should be done in patients without constipation. Moreover, non-celiac disease gluten sensitivity, defined as gluten intolerance once celiac disease and wheat allergy have been ruled out, should be considered in these patients. There is no specific diet for IBS patients but small and frequent meals, avoiding greasy foods, dairy products, many carbohydrates, caffeine and alcohol, is recommended.

  2. A NEARLY POLAR ORBIT FOR THE EXTRASOLAR HOT JUPITER WASP-79b

    Energy Technology Data Exchange (ETDEWEB)

    Addison, B. C.; Tinney, C. G.; Wright, D. J. [Exoplanetary Science Group, School of Physics, University of New South Wales, NSW 2052 (Australia); Bayliss, D.; Zhou, G.; Schmidt, B. [Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 2611 (Australia); Hartman, J. D.; Bakos, G. A., E-mail: b.addison@unsw.edu.au [Department of Astrophysical Sciences, Princeton University, NJ 08544 (United States)

    2013-09-01

    We report the measurement of a spin-orbit misalignment for WASP-79b, a recently discovered, bloated hot Jupiter from the Wide Angle Search for Planets (WASP) survey. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. We have used the Rossiter-McLaughlin effect to determine the sky-projected spin-orbit angle to be {lambda}= -106{sup +19}{sub -13} {sup o}. This result indicates a significant misalignment between the spin axis of the host star and the orbital plane of the planet-the planet being in a nearly polar orbit. WASP-79 is consistent with other stars that have T{sub eff} > 6250 K and host hot Jupiters in spin-orbit misalignment.

  3. The Feasibility of Using Black Widow Pulsars in Pulsar Timing Arrays for Gravitational Wave Detection

    CERN Document Server

    Bochenek, Christopher; Demorest, Paul

    2015-01-01

    In the past five years, approximately one third of the 65 pulsars discovered by radio observations of Fermi unassociated sources are black widow pulsars (BWPs). BWPs are binary millisecond pulsars with companion masses ranging from 0.01-0.1 solar masses which often exhibit radio eclipses. The bloated companions in BWP systems exert small torques on the system causing the orbit to change on small but measurable time scales. Because adding parameters to a timing model reduces sensitivity to a gravitational wave (GW) signal, the need to fit many orbital frequency derivatives to the timing data is potentially problematic for using BWPs to detect GWs with pulsar timing arrays. Using simulated data with up to four orbital frequency derivatives, we show that fitting for orbital frequency derivatives absorbs less than 5% of the low frequency spectrum expected from a stochastic gravitational wave background signal. Furthermore, this result does not change with orbital period. Therefore, we suggest that if timing syste...

  4. Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals?

    Science.gov (United States)

    Barrett, Jacqueline S; Gibson, Peter R

    2012-07-01

    Food intolerance in irritable bowel syndrome (IBS) is increasingly being recognized, with patients convinced that diet plays a role in symptom induction. Evidence is building to implicate fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) in the onset of abdominal pain, bloating, wind and altered bowel habit through their fermentation and osmotic effects. Hypersensitivity to normal levels of luminal distension is known to occur in patients with IBS, with consideration of food chemical intolerance likely to answer many questions about this physiological process. This paper summarizes the evidence and application of the most common approaches to managing food intolerance in IBS: the low-FODMAP diet, the elimination diet for food chemical sensitivity and others including possible noncoeliac gluten intolerance.

  5. Dietary fructose intolerance, fructan intolerance and FODMAPs.

    Science.gov (United States)

    Fedewa, Amy; Rao, Satish S C

    2014-01-01

    Dietary intolerances to fructose, fructans and FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) are common, yet poorly recognized and managed. Over the last decade, they have come to the forefront because of new knowledge on the mechanisms and treatment of these conditions. Patients with these problems often present with unexplained bloating, belching, distension, gas, abdominal pain, or diarrhea. Here, we have examined the most up-to-date research on these food-related intolerances, discussed controversies, and have provided some guidelines for the dietary management of these conditions. Breath testing for carbohydrate intolerance appears to be standardized and essential for the diagnosis and management of these conditions, especially in the Western population. While current research shows that the FODMAP diet may be effective in treating some patients with irritable bowel syndrome, additional research is needed to identify more foods items that are high in FODMAPs, and to assess the long-term efficacy and safety of dietary interventions.

  6. Lactose intolerance: from diagnosis to correct management.

    Science.gov (United States)

    Di Rienzo, T; D'Angelo, G; D'Aversa, F; Campanale, M C; Cesario, V; Montalto, M; Gasbarrini, A; Ojetti, V

    2013-01-01

    This review discusses one of the most relevant problems in gastrointestinal clinical practice: lactose intolerance. The role of lactase-persistence alleles the diagnosis of lactose malabsorption the development of lactose intolerance symptoms and its management. Most people are born with the ability to digest lactose, the major carbohydrate in milk and the main source of nutrition until weaning. Approximately, 75% of the world's population loses this ability at some point, while others can digest lactose into adulthood. Symptoms of lactose intolerance include abdominal pain, bloating, flatulence and diarrhea with a considerable intraindividual and interindividual variability in the severity. Diagnosis is most commonly performed by the non invasive lactose hydrogen breath test. Management of lactose intolerance consists of two possible clinical choice not mutually exclusive: alimentary restriction and drug therapy.

  7. Celiac disease and gluten-associated diseases.

    Science.gov (United States)

    Helms, Steve

    2005-09-01

    Celiac disease develops from an autoimmune response to specific dietary grains that contain gluten. Diagnosis can be made based on the classical presentation of diarrhea, fatty stools, and abdominal bloating and cramping, as well as the presence of specific serum antibodies. In addition, gluten ingestion has increasingly been found to be associated with other conditions not usually correlated with gluten intolerance. The subsequent diversity of the clinical presentation in these cases can complicate decision-making and delay treatment initiation in conditions such as ataxia, headaches, arthritis, neuropathy, type 1 diabetes mellitus, and others. This review explores the etiology and pathology of celiac disease, presents support for the relationship between gluten and other diseases, and provides effective screening and treatment protocols.

  8. Antimesenteric jejunal diverticulosis after a remote history of necrotising enterocolitis: a case report.

    Science.gov (United States)

    Monteiro, Rosebel; Schneble, Erica; Mino, Jeffrey; Stallion, Anthony

    2013-04-22

    Jejunal diverticulosis is a rare, acquired pathology of the small bowel. While most patients are asymptomatic, the condition is difficult to diagnose. It may present with chronic abdominal pain, diarrhoea, bloating and complications including malabsorption, diverticulitis, bleeding, intestinal obstruction or perforation. This is a case presentation of a 27-year-old woman with a history of necrotising enterocolitis (NEC) requiring surgical resection as a premature newborn who presented with recurrent abdominal pain and was found to have several small bowel diverticula intraoperatively. She underwent resection with complete resolution of symptoms over a 2-year follow-up. This is the first case report to suggest that small bowel diverticular disease as a long-term complication of NEC may result in chronic morbidity in long-term survivors.

  9. Explosions Triggered by Violent Binary-Star Collisions: Application to Eta Carinae and other Eruptive Transients

    CERN Document Server

    Smith, Nathan

    2010-01-01

    This paper discusses a model where a violent periastron collision of stars in an eccentric binary system induces an eruption or explosion seen as a brief transient source, attributed to LBVs, SN impostors, or other transients. The key ingredient is that an evolved primary increases its photospheric radius on relatively short timescales, to a point where the radius is comparable to or larger than the periastron separation in an eccentric binary. In such a configuration, a violent and sudden collision would ensue, possibly leading to substantial mass ejection instead of a binary merger. Repeated periastral grazings in an eccentric system could quickly escalate to a catastrophic encounter, wherein the companion star actually plunges deep inside the photosphere of a bloated primary during periastron, as a result of the primary star increasing its own radius. This is motivated by the case of $\\eta$~Carinae, where such a collision must have occured if conventional estimates of the present-day orbit are correct, and...

  10. The use of fecal calprotectin as a biomarker in gastrointestinal disease.

    Science.gov (United States)

    Burri, Emanuel; Beglinger, Christoph

    2014-02-01

    Abdominal discomfort including pain, bloating and diarrhea is common. It often arises from functional gastrointestinal disorders but may indicate inflammatory bowel disease (IBD). Calprotectin is an abundant neutrophil protein that is released during inflammation. When measured in feces, it can be used to differentiate between non-organic and inflammatory intestinal disorders, especially to identify IBD. Fecal calprotectin might also be useful to monitor patients with IBD under treatment and to predict the risk of recurrence of active disease prior to clinical relapse. The use of fecal calprotectin has been investigated in a number of gastrointestinal disorders other than IBD, for example, as screening test for colorectal cancer but the available data are limited. This article summarizes the current literature on the use of fecal calprotectin in clinical practice.

  11. Treating 12 cases of fever in children with simple food by abdominal massage%腹部按摩治疗小儿单纯性食积发热12例

    Institute of Scientific and Technical Information of China (English)

    张茂亮

    2013-01-01

    Children dyspepsia fever, is a common disease in pediatrics, the thermal potential not too high, on a low calorie, with stomach bloating, belching acid, do not think of eating, restless, restless sleep,not nearly clothing, poor stool symptoms, abdominal massage therapy, 12 patients with dyspepsia in children with fever were alleviated.%小儿食积发热,是当今小儿科的一种常见病,此病热势多不太高,以低热为主,多伴有肚腹胀热,嗳气酸腐,不思饮食,烦躁不安,睡眠不安,不近衣被,大便不畅诸症,经腹部按摩治疗,12例单纯性食积发热的患儿均得到了缓解。

  12. Mild protein hydrolysation of lactose-free milk further reduces milk-related gastrointestinal symptoms.

    Science.gov (United States)

    Turpeinen, Anu; Kautiainen, Hanna; Tikkanen, Marja-Leena; Sibakov, Timo; Tossavainen, Olli; Myllyluoma, Eveliina

    2016-05-01

    Gastrointestinal symptoms associated with milk are common. Besides lactose, milk proteins may cause symptoms in sensitive individuals. We have developed a method for mild enzymatic hydrolysation of milk proteins and studied the effects of hydrolysed milk on gastrointestinal symptoms in adults with a self-diagnosed sensitive stomach. In a double blind, randomised placebo-controlled study, 97 subjects consumed protein-hydrolysed lactose-free milk or commercially available lactose-free milk for 10 d. Frequency of gastrointestinal symptoms during the study period was reported and a symptom score was calculated. Rumbling and flatulence decreased significantly in the hydrolysed milk group (P < 0·05). Also, the total symptom score was lower in subjects who consumed hydrolysed milk (P < 0·05). No difference between groups was seen in abdominal pain (P = 0·47) or bloating (P = 0·076). The results suggest that mild enzymatic protein hydrolysation may decrease gastrointestinal symptoms in adults with a sensitive stomach.

  13. Probiotics supplementation for athletes - clinical and physiological effects.

    Science.gov (United States)

    Pyne, David B; West, Nicholas P; Cox, Amanda J; Cripps, Allan W

    2015-01-01

    Probiotic supplementation has traditionally focused on gut health. However, in recent years, the clinical applications of probiotics have broadened to allergic, metabolic, inflammatory, gastrointestinal and respiratory conditions. Gastrointestinal health is important for regulating adaptation to exercise and physical activity. Symptoms such as nausea, bloating, cramping, pain, diarrhoea and bleeding occur in some athletes, particularly during prolonged exhaustive events. Several studies conducted since 2006 examining probiotic supplementation in athletes or highly active individuals indicate modest clinical benefits in terms of reduced frequency, severity and/or duration of respiratory and gastrointestinal illness. The likely mechanisms of action for probiotics include direct interaction with the gut microbiota, interaction with the mucosal immune system and immune signalling to a variety of organs and systems. Practical issues to consider include medical and dietary screening of athletes, sourcing of recommended probiotics and formulations, dose-response requirements for different probiotic strains, storage, handling and transport of supplements and timing of supplementation in relation to travel and competition.

  14. Tolazoline reversal of xylazine in bison (Bison bison): Mitigation of adverse effects

    Science.gov (United States)

    Roffe, Thomas J.; Sweeney, Steven J.; Williams, Beth; Quist, Charlotte

    2002-01-01

    Tolazoline is a mixed alpha-1 and -2 adrenergic antagonist used to reverse the sedative, analgesic and muscle-relaxing effects of xylazine, a potent alpha adrenergic agonist. Tolazoline has been used in cattle and is superior to yohimbine, another alpha adrenergic antagonist, in this species. In white-tailed deer, tolazoline shortened recovery times and reversed xylazine-induced bradycardia, respiratory depression, and bloat following xylazine-ketamine anesthesia (Kreeger et al. 1986). We have used it for a number of years in moose without any detected adverse reactions. Caulkett et al. (2000) used tolazoline in wood bison to reverse the xylazine-induced effects of xylazine-tiletamine/zolazepam anesthesia and did not report any ill effects. However, the reported side effects of tolazoline in horses (species for which the drug was developed and is labeled) include abdominal discomfort, gastrointestinal hypermotility, diarrhea, tachycardia, ventricular dysrhythmia, hypertension and apprehensiveness.

  15. The Transit Light Curve project. XIV. Confirmation of Anomalous Radii for the Exoplanets TrES-4b, HAT-P-3b, and WASP-12b

    CERN Document Server

    Chan, Tucker; Winn, Joshua N; Holman, Matthew J; Sanchis-Ojeda, Roberto; Esquerdo, Gil; Everett, Mark

    2011-01-01

    We present transit photometry of three exoplanets, TrES-4b, HAT-P-3b, and WASP-12b, allowing for refined estimates of the systems' parameters. TrES-4b and WASP-12b were confirmed to be "bloated" planets, with radii of 1.706 +/- 0.056 R_Jup and 1.736 +/- 0.092 R_Jup, respectively. These planets are too large to be explained with standard models of gas giant planets. In contrast, HAT-P-3b has a radius of 0.827 +/- 0.055 R_Jup, smaller than a pure hydrogen-helium planet and indicative of a highly metal-enriched composition. Analyses of the transit timings revealed no significant departures from strict periodicity. For TrES-4, our relatively recent observations allow for improvement in the orbital ephemerides, which is useful for planning future observations.

  16. Pancreatic Lymphoepithelial Cyst with an Intracystic Papillary Projection. Report of a Case

    Directory of Open Access Journals (Sweden)

    Hiroshi Maekawa

    2009-11-01

    Full Text Available Context Lymphoepithelial cysts of the pancreas show various presentations on imaging studies often making a differential diagnosis difficult. Case report A 58-year-old man was admitted to our hospital with epigastric discomfort and abdominal bloating. Abdominal US was carried out and demonstrated a cystic lesion 5 cm in diameter which included an intracystic projection into the pancreatic body. This intracystic projection was also seen on CT and MR images. On FDG-PET images, the projection was positively visualized. Since we could not exclude a pancreatic cystic neoplasm, a distal pancreatectomy was performed. Postoperative pathological examination demonstrated that the lesion was a lymphoepithelial cyst of the pancreas. There were no atypical cells in the intracystic projection. Conclusion Resection is inevitable when a true pancreatic neoplasm cannot be excluded.

  17. Ileus caused by cholesterol crystal embolization: A case report.

    Science.gov (United States)

    Azuma, Shunjiro; Ikenouchi, Maiko; Akamatsu, Takuji; Seta, Takeshi; Urai, Shunji; Uenoyama, Yoshito; Yamashita, Yukitaka

    2016-03-28

    Cholesterol crystal embolization (CCE) is a rare systemic embolism caused by formation of cholesterol crystals from atherosclerotic plaques. CCE usually occurs during vascular manipulation, such as vascular surgery or endovascular catheter manipulation, or due to anticoagulation or thrombolytic therapy. We report a rare case of intestinal obstruction caused by spontaneous CCE. An 81-year-old man with a history of hypertension was admitted for complaints of abdominal pain, bloating, and anorexia persisting for 4 mo. An abdominal computed tomography revealed intestinal ileus. His symptoms were immediately relieved by an ileus tube insertion, and he was discharged 6 d later. However, these symptoms immediately reappeared and persisted, and partial resection of the small intestine was performed. A histopathological examination indicated that small intestine obstruction was caused by CCE. At the 12-mo follow-up, the patient showed no evidence of CCE recurrence. Thus, in cases of intestinal obstruction, CCE should also be considered.

  18. Carum copticum L.: A Herbal Medicine with Various Pharmacological Effects

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Boskabady

    2014-01-01

    Full Text Available Carum copticum L. commonly known as “Ajwain” is cultivated in many regions of the world including Iran and India, states of Gujarat and Rajasthan. Traditionally, C. copticum has been used in the past for various therapeutic effects including bloating, fatigue, diarrhea, abdominal tumors, abdominal pain, respiratory distress, and loss of appetite. It has other health benefits such as antifungal, antioxidant, antibacterial, antiparasitic, and hypolipidemic effects. This plant contains different important components such as carbohydrates, glucosides, saponins and phenolic compounds (carvacrol, volatile oils (thymol, terpiene, paracymene and beta-pinene, protein, fat, fiber, and minerals including calcium, phosphorus, iron, and nicotinic acid (niacin. In the previous studies, several pharmacological effects were shown for C. copticum. Therefore, in this paper, the pharmacological effects of the plant were reviewed.

  19. It is possible to classify non-erosive reflux disease (NERD) patients into endoscopically normal groups and minimal change groups by subjective symptoms and responsiveness to rabeprazole -- a report from a study with Japanese patients.

    Science.gov (United States)

    Kusano, Motoyasu; Shirai, Naohito; Yamaguchi, Kanako; Hongo, Michio; Chiba, Tsutomu; Kinoshita, Yoshikazu

    2008-12-01

    The hypothesis that non-erosive reflux disease (NERD) patients comprise various subgroups is gaining popularity. This study was conducted to investigate the possibility of categorizing NERD patients according to symptom types and response to acid-suppressive drug rabeprazole (RPZ) 10 mg/day. NERD patients were classified as grade N (endoscopically normal), M (minimal change), or erosive GERD, and answered a 51-item, yes-or-no questionnaire pre and post-treatment. Compared to erosive GERD, clear differences existed in pretreatment prevalence of symptoms and responsiveness to RPZ in grades N and M; the results suggested stomachaches (especially at night) were significant symptoms in grade N and dysmotility-like symptoms like bloated stomach were significant in grade M while gastroesophageal reflux symptoms were significant in erosive GERD. Clinical significance of classifying NERD was indicated from different symptoms and responsiveness to PPI.

  20. EFSA NDA Panel ( EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to Bimuno ® GOS and reducing gastro - intestinal discomfort pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    on the scientific substantiation of a health claim related to Bimuno® GOS and reducing gastro-intestinal discomfort. The food constituent, Bimuno® GOS, a mixture of β-galacto-oligosaccharides, which is the subject of the health claim, is sufficiently characterised. The claimed effect proposed by the applicant...... is “reduce bloating, flatulence and abdominal pain. These effects can be described collectively as abdominal discomfort” and the target population proposed by the applicant is the general adult population. Reducing gastro-intestinal discomfort is a beneficial physiological effect. A health claim on Bimuno......® GOS and reducing gastro-intestinal discomfort has already been assessed by the Panel with an unfavourable outcome. The supplementary information submitted by the applicant in this application did not provide evidence that could be used for the scientific substantiation of this claim. © European Food...

  1. Applying natural evolution for solving computational problems - Lecture 1

    CERN Document Server

    CERN. Geneva

    2017-01-01

    Darwin’s natural evolution theory has inspired computer scientists for solving computational problems. In a similar way to how humans and animals have evolved along millions of years, computational problems can be solved by evolving a population of solutions through generations until a good solution is found. In the first lecture, the fundaments of evolutionary computing (EC) will be described, covering the different phases that the evolutionary process implies. ECJ, a framework for researching in such field, will be also explained. In the second lecture, genetic programming (GP) will be covered. GP is a sub-field of EC where solutions are actual computational programs represented by trees. Bloat control and distributed evaluation will be introduced.

  2. Applying natural evolution for solving computational problems - Lecture 2

    CERN Document Server

    CERN. Geneva

    2017-01-01

    Darwin’s natural evolution theory has inspired computer scientists for solving computational problems. In a similar way to how humans and animals have evolved along millions of years, computational problems can be solved by evolving a population of solutions through generations until a good solution is found. In the first lecture, the fundaments of evolutionary computing (EC) will be described, covering the different phases that the evolutionary process implies. ECJ, a framework for researching in such field, will be also explained. In the second lecture, genetic programming (GP) will be covered. GP is a sub-field of EC where solutions are actual computational programs represented by trees. Bloat control and distributed evaluation will be introduced.

  3. An open-label pilot study to assess the effectiveness of krill oil with added vitamins and phytonutrients in the relief of symptoms of PMS

    Directory of Open Access Journals (Sweden)

    Wakeman MP

    2013-09-01

    Full Text Available Michael P Wakeman School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, UK Abstract: An open-label pilot study over 4 months to evaluate the effectiveness of a compound formulation of ingredients, which individually have been demonstrated to be implicated in the pathogenesis of premenstrual syndrome to ameliorate the most troublesome symptoms of the condition. The supplement provided thiamine, riboflavin, pyridoxine, vitamin D, soy isoflavones, rosemary extract, and krill oil and was taken each day for the 3 months of the trial. Statistically significant effect was reported by the 29 women who completed the study in relief of anxiety, bloating, mood swings, breast tenderness, skin outbreaks, food cravings, fatigue, forgetfulness, insomnia, and headache after 3 months of treatment compared with baseline. This pilot study indicates the formulation to be effective, and a larger placebo-controlled trial is now planned. Keywords: thiamine, riboflavin, pyridoxine, vitamin D, soy isoflavones, rosemary extract, premenstrual syndrome

  4. Alpha 2 Delta (α2δ Ligands, gabapentin and pregabalin: what is the evidence for potential use of these ligands in irritable bowel syndrome

    Directory of Open Access Journals (Sweden)

    Jeremy eGale

    2011-06-01

    Full Text Available Irritable bowel syndrome (IBS is a complex disorder that is characterized by abdominal pain and altered bowel habit, and often associates with other gastrointestinal symptoms such as feelings of incomplete bowel movement and abdominal bloating, and extra-intestinal symptoms such as headache, dyspareunia, heartburn, muscle pain and back pain. It also frequently coexists with conditions that may also involve central sensitization processes, such as fibromyalgia, irritable bladder disorder and chronic cough. This review examines the evidence to date on gabapentin and pregabalin which may supports further and continued research and development of the α2δ ligands in disorders characterized by visceral hypersensitivity, such as IBS. The distribution of the α2δ sub-unit of the voltage-gated calcium channel, possible mechanisms of action, pre-clinical data which supports an effect on motor-sensory mechanisms and clinical evidence that points to potential benefits in these patients with IBS will be discussed.

  5. [Antagonists of the type 3 serotonin receptor (5 -HT3) in IBS].

    Science.gov (United States)

    Komoto, Shunsuke; Miura, Soichiro

    2006-08-01

    Irritable bowel syndrome (IBS) is a common chronic gastrointestinal (GI) disorder, but its pathophysiology remains unknown. 5-hydroxytryptamine (5-HT, serotonin) is an important neurotransmitter involved in the brain-gut connection. Alosetron, a 5-HT3 receptor antagonist, has been demonstrated in randomized, placebo-controlled trials (RCT) to be effective in diarrhea-predominant IBS(IBS-D). Constipation is the most common adverse event. Alosetron improved abdominal pain and discomfort and stool consistency in both female and male patients, but it did not improve other symptoms (sense of urgency, stool frequency and bloating) in male patients. Although less is known about the gender differences in therapeutic benefit, a new 5-HT3 antagonist, cilansetron, has demonstrated effectiveness in male and female IBS-D patients and is currently under clinical trials.

  6. September 2014 critical care case of the month: bad case of colic

    Directory of Open Access Journals (Sweden)

    Andrews S

    2014-09-01

    Full Text Available No abstract available. Article truncated after 150 words. History of Present Illness: A 70 year old man with a past medical history of chronic kidney disease, bipolar disorder, benign prostatic hypertrophy, hypertension and diabetes presented to the emergency department with constipation associated with bloating for 15 days. He denies flatus. He tried over the counter laxatives (polyethylene glycol with no relief. He has no recent history of colonoscopy or recent antibiotic use. He denies chills, diarrhea, dysuria, fever, hematochezia, hematuria, melena, nausea or vomiting. In the emergency department, he is tachypneic with a grossly distended abdomen. Past Medical History: diabetes; hypertension; chronic kidney disease; bipolar disorder; benign prostatic hypertrophy; hyperlipidemia. Past Surgical History: cholecystectomy 2012. Medications: aspirin 81 mg daily; furosemide 20 mg daily; quetiapine 300 daily; doxazosin- 4 mg daily; clonazepam 1 mg – twice daily as needed; simvastatin 20 mg – daily; pioglitazone 15 ...

  7. Effect of psyllium gum and wheat bran on spontaneous energy intake.

    Science.gov (United States)

    Stevens, J; Levitsky, D A; VanSoest, P J; Robertson, J B; Kalkwarf, H J; Roe, D A

    1987-11-01

    Energy intake, fecal energy output, and gastrointestinal symptoms were measured in 12 females who consumed either approximately 23 g/d supplementary fiber or a 4 g/d fiber control. Fiber supplements were crackers containing psyllium gum, wheat bran, or a combination of the two fiber sources. After 1 wk on the control cracker, subjects consumed the three high-fiber crackers and the control cracker for 2-wk periods in a balanced design. Gum and combination supplements gave increased bloating and flatulence. Increase in abdominal pain was reported with gum supplement. Mean daily fecal energy was 96 kcal/d with control crackers and was increased by 63 kcal with high-fiber crackers. Gum and combination supplements significantly decreased intake of digestible energy by 153 and 115 kcal/d, respectively. This suppression was not dependent upon fiber intolerance. Wheat bran supplement had no effect on energy intake.

  8. Effects of Bermudagrass hay and soybean hulls inclusion on performance of sheep fed cactus-based diets.

    Science.gov (United States)

    Santos, A O A; Batista, Angela M V; Mustafa, Arif; Amorim, G L; Guim, A; Moraes, A C; de Lucena, R B; de Andrade, R

    2010-03-01

    The objective of this experiment was to determine the effects of replacing corn with soybean hulls (SH) or Bermudagrass tifton hay (TH) on performance of sheep fed cactus-based diets. Three ruminally fistulated sheep were used in a 3 x 3 Latin square experiment with 21-day periods. All diets contained 75% spineless cactus (dry matter basis, DM) and formulated to be isonitrogenous. Fiber source had no influence on nutrient intakes except for the intake of neutral detergent fiber (NDF) which was lower (pcactus-based diet had no effect on nutrient intakes or total tract nutrient utilization. Changes in ruminal fermentation parameters reflected differences in ruminal degradability between the two fiber sources. Bermudagrass tifton hay was more effective than SH in reducing the risk of bloat associated with feeding high levels of spineless cactus to ruminants.

  9. PREVALENCE OF HELICOBACTER PYLORI INFECTION IN PATIENTS WITH DYSPEPSIA

    Directory of Open Access Journals (Sweden)

    Chandrashekar

    2015-08-01

    Full Text Available Dyspepsia is synonymous with commonly used non - medical term indigestion . It includes symptoms like pain , bloating , nausea & early satiety . I t is now recognized that the large majority of duodenal and gastric ulcers are caused by H. pylori infection and/or NSAID use . H. pylori infection is associated with poverty, household crowding & limited education. Colonization rates exceed 70% in some groups and vary from less than 10% to more than 80% worldwide. Several studies have revealed the association of H. pylori in 70 – 75% of patients with dyspepsia. The aim o f this study is t o study the prevalence of H. pylori infection in dyspeptic patients. To study the various upper GI endoscopy findings in dyspeptic patients.

  10. Gastrointestinal involvement in systemic sclerosis.

    Science.gov (United States)

    Savarino, Edoardo; Furnari, Manuele; de Bortoli, Nicola; Martinucci, Irene; Bodini, Giorgia; Ghio, Massimo; Savarino, Vincenzo

    2014-10-01

    Systemic sclerosis is an autoimmune chronic disease characterised by microvascular, muscular and immunologic abnormalities that lead to progressive and systemic deposition of connective tissue in the skin and internal organs. The gastrointestinal tract is often overlooked by physicians but it is the most affected organ after the skin, from the mouth to the anus. Indeed, 80% of SSc patients may present with gastrointestinal involvement. Gastrointestinal manifestations range from bloating and heartburn to dysphagia and anorectal dysfunction to severe weight loss and malabsorption. However, the gastrointestinal involvement is rarely the direct cause of death, but has great impact on quality of life and leads to several comorbidities that subsequently affect patients' survival. Treatments, including nutritional support and prokinetics provide limited benefits and do not arrest the progressive course of the disease, but earlier detection of gastrointestinal involvement may reduce the risk of complications such as malnutrition.

  11. Ogilvie's syndrome with caecal perforation after Caesarean section: a case report

    Directory of Open Access Journals (Sweden)

    Saha Arin K

    2009-06-01

    Full Text Available Abstract Introduction Ogilvie's syndrome describes the phenomenon of an acute colonic pseudo-obstruction without a mechanical cause. It is rare but has been reported to occur after Caesarean section. It can lead to bowel perforation or ischaemia. Case presentation A healthy, 28-year-old Caucasian woman presented 2 weeks past her expected date of delivery for her first pregnancy. She underwent an uncomplicated elective Caesarean section but developed abdominal pain and bloating postoperatively and was subsequently diagnosed with acute colonic pseudo-obstruction, also known as Ogilvie's syndrome. Conclusion This case report highlights the rare, but potentially dangerous, diagnosis of Ogilvie's syndrome after Caesarean section. It is of particular interest to obstetricians, midwifery staff and general surgeons and shows the importance of accurate diagnosis, regular abdominal reassessment and early senior input to ensure appropriate and rapid treatment.

  12. Formation of Massive Primordial Stars: Intermittent UV Feedback with Episodic Mass Accretion

    Science.gov (United States)

    Hosokawa, Takashi; Hirano, Shingo; Kuiper, Rolf; Yorke, Harold W.; Omukai, Kazuyuki; Yoshida, Naoki

    2016-06-01

    We present coupled stellar evolution (SE) and 3D radiation-hydrodynamic (RHD) simulations of the evolution of primordial protostars, their immediate environment, and the dynamic accretion history under the influence of stellar ionizing and dissociating UV feedback. Our coupled SE RHD calculations result in a wide diversity of final stellar masses covering 10 {M}⊙ ≲ M * ≲ 103 {M}⊙ . The formation of very massive (≳250 {M}⊙ ) stars is possible under weak UV feedback, whereas ordinary massive (a few ×10 {M}⊙ ) stars form when UV feedback can efficiently halt the accretion. This may explain the peculiar abundance pattern of a Galactic metal-poor star recently reported by Aoki et al., possibly the observational signature of very massive precursor primordial stars. Weak UV feedback occurs in cases of variable accretion, in particular when repeated short accretion bursts temporarily exceed 0.01 {M}⊙ {{{yr}}}-1, causing the protostar to inflate. In the bloated state, the protostar has low surface temperature and UV feedback is suppressed until the star eventually contracts, on a thermal adjustment timescale, to create an H ii region. If the delay time between successive accretion bursts is sufficiently short, the protostar remains bloated for extended periods, initiating at most only short periods of UV feedback. Disk fragmentation does not necessarily reduce the final stellar mass. Quite the contrary, we find that disk fragmentation enhances episodic accretion as many fragments migrate inward and are accreted onto the star, thus allowing continued stellar mass growth under conditions of intermittent UV feedback. This trend becomes more prominent as we improve the resolution of our simulations. We argue that simulations with significantly higher resolution than reported previously are needed to derive accurate gas mass accretion rates onto primordial protostars.

  13. Herbal Remedies for Functional Dyspepsia and Traditional Iranian Medicine Perspective

    Science.gov (United States)

    Babaeian, Mahmoud; Naseri, Mohsen; Kamalinejad, Mohammad; Ghaffari, Farzaneh; Emadi, Fatemeh; Feizi, Awat; Hosseini Yekta, Nafiseh; Adibi, Peyman

    2015-01-01

    Context: Functional dyspepsia (FD) is a functional gastro-intestinal disorder with high prevalence. Among various treatment options, treatment by complementary and alternative medicines especially herbal remedies also practiced. Traditional Iranian medicine (TIM), a valuable resource of valid applied studies of ancient Iranian scholars, recommends numerous medicinal plants to treat dyspepsia symptoms. In this study, through investigation of TIM references, we aimed to identify medicinal plants for treatment of digestion insufficiency. Evidence Acquisition: In this qualitative study, dyspepsia symptoms including fullness, early satiety, bloating, nausea, and belching were checked under reliable sources of traditional medicine. Then medicinal plants recommended for the treatment of the symptoms were extracted from the books. Likewise, for investigating the pharmacological properties of medicinal plants used for the relieving of dyspepsia symptoms, electronic databases such as PubMed, Scopus, Google Scholar and some Iranian databases like SID and IranMedex were employed. Results: The study yielded 105 plants from 37 families which could treat various dyspepsia symptoms; fifty-seven plants, mainly from Apiaceae, Lamiaceae, Amaryllidaceae and Zingiberaceae had digestive effects. In this research, based on the information in TIM reference texts, we obtained 58 plants effective for bloating, 40 for nausea, 37 for appetite loss and 7 for belching. In human clinical trials conducted on medicinal plants effective for FD symptoms, 7 single plants were used. Conclusions: Finding the medicinal plants effective on digestion insufficiency based on TIM could suggest a better strategy for the relieving of dyspepsia symptoms. Traditional Iranian medicine prescribes medicinal plants based on each patient’s personal characteristics and practices multiple target therapies. PMID:26734483

  14. Degenerative and regenerative changes in epidermal organ culture: a morphological study with reference to membrane-coating granules.

    Science.gov (United States)

    Chapman, S J; Vickers, C F

    1988-11-01

    Membrane-coating granules (MCG) are poorly understood lamellate organelles unique to keratinized epithelia. This study provides data on a skin model for future in vitro investigations of MCG. Porcine ear epidermal organ cultures were used under standard cell culture conditions. This system was selected because it is easily established and, following a degenerative period in which MCG are lost, regenerates to form a highly differentiated epidermis. The epidermis appeared healthy during the first 2 d in vitro and contained MCG but lost keratohyalin granules (KHG). Overt degenerative changes were evident in the upper epidermis on Day 3, and MCG were now bloated. By Day 4 only one to three layers of viable undifferentiated cells remained. In the overlying necrotic epidermis MCG were rare, presumably due to the bursting of bloated MCG. Epidermal regeneration began around Day 5 and by Day 7 there were 8 to 13 layers, including a rudimentary parakeratotic stratum corneum (up to 4 layers). The stratum granulosum (two to three layers) now contained immature KHG and poorly lamellate MCG, but only amorphous material extracellularly. By Day 11 there were three to four layers of granular cells as in vivo, and an orthokeratotic stratum corneum (two to four layers). Improved cornification coincided with an increased number of mature KHG and cross-banded MCG, and lamellate MCG contents extracellularly. This model of epidermal regeneration will facilitate studies into the role played by MCG in keratinization because the epithelium initially lacked MCG but later expressed all the major morphologic features of epidermis. Furthermore the mechanisms by which MCG translocation and extrusion are effected may be probed by the inclusion of such agents as antimicrotubular drugs and calcium ionophores.

  15. Characteristics of Children Admitted to Hospital for Constipation

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    Sevim Savaşer

    2011-12-01

    Full Text Available Introduction: The aim of this study was to determine the sociodemographic characteristics of children with constipation, the causes of constipations in these children and the common practices of the parents to solve the problem of constipation.Materials and Methods: The population of the study was comprised of children aged 1 to 16 years followed with the diagnosis of functional constipation in the outpatient clinics of pediatric surgery at a university hospital in Istanbul between 1 June 2009-1 June 2010. A total of 146 children and their parents who agreed to participate in the study were included. The data of this descriptive cross-sectional study were obtained by using a questionnaire which was evaluated by appropriate statistical analysis.Results: About half of the children in the study were between 1-3 years old and females. We detected that in approximately half of the children constipation problem began during transition period from solid foods before age 1. The majority of children experienced abdominal pain, bloating, stool retention, fear and anxiety during bowel movements, hard/painful defecation, increased stool volume and fecal mass; and that though it varied according to age groups, most of the children drank olive oil and fruit juice to overcome constipation. Families of children in all age groups affected in similar proportions by constipation problem and this problem did not affect sibling relations.Discussion: Risk factors for constipation were found to be under 4 years of age, starting additional/solid foods before 6 months, starting school, having family members with constipation, feeling fear and anxiety during defecation and having symptoms arising from stool retention such as abdominal pain, abdominal bloating, and hard and painful defecation. (Journal of Current Pediatrics 2011; 9: 103-9

  16. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study.

    Science.gov (United States)

    Ouwehand, Arthur C; DongLian, Cai; Weijian, Xu; Stewart, Morgan; Ni, Jiayi; Stewart, Tad; Miller, Larry E

    2014-01-16

    Probiotics are known to reduce antibiotic associated diarrhea (AAD) and Clostridium difficile associated diarrhea (CDAD) risk in a strain-specific manner. The aim of this study was to determine the dose-response effect of a four strain probiotic combination (HOWARU(®) Restore) on the incidence of AAD and CDAD and severity of gastrointestinal symptoms in adult in-patients requiring antibiotic therapy. Patients (n=503) were randomized among three study groups: HOWARU(®) Restore probiotic 1.70×10(10) CFU (high-dose, n=168), HOWARU(®) Restore probiotic 4.17×10(9) CFU (low-dose, n=168), or placebo (n=167). Subjects were stratified by gender, age, and duration of antibiotic treatment. Study products were administered daily up to 7 days after the final antibiotic dose. The primary endpoint of the study was the incidence of AAD. Secondary endpoints included incidence of CDAD, diarrhea duration, stools per day, bloody stools, fever, abdominal cramping, and bloating. A significant dose-response effect on AAD was observed with incidences of 12.5, 19.6, and 24.6% with high-dose, low-dose, and placebo, respectively (p=0.02). CDAD was the same in both probiotic groups (1.8%) but different from the placebo group (4.8%; p=0.04). Incidences of fever, abdominal pain, and bloating were lower with increasing probiotic dose. The number of daily liquid stools and average duration of diarrhea decreased with higher probiotic dosage. The tested four strain probiotic combination appears to lower the risk of AAD, CDAD, and gastrointestinal symptoms in a dose-dependent manner in adult in-patients.

  17. Lactose intolerance in Indonesian children.

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    Hegar, Badriul; Widodo, Ariani

    2015-01-01

    "Lactose intolerance (LI)" is considered a common problem in Asians, and in many parts of the world. Its prevalence and age of manifestation varies between by Asian country, for possible genetic or cultural reasons. Studies in Indonesian children 3-15 years old (y) are available within the past two decades, using a pure lactose tolerance test. The prevalences of lactose malabsorption (LM) in pre-elementary (3-5 y), elementary (6-11 y), and junior high (12-14 y) school-children were 21.3%, 57.8%, and 73%, respectively. An increasing trend for LM prevalence was seen within the pre-elementary group, from 9.1% at 3 y to 28.6% at 5 y. The most frequent symptoms of LI in junior high school (JHS) group were abdominal pain (64.1%), abdominal distention (22.6%), nausea (15.1%), flatulence (5.7%), and diarrhea (1.9%), mostly within one hour of lactose ingestion. In children with regular and irregular milk drinking, LM occurred in 81.2% and 69.6%; LI was found in 56.2% and 52.1%, respectively. Most JHS children with dairy-associated recurrent abdominal pain (RAP) symptoms proved to be malabsorbers. Dairy products most related to RAP were milk and yogurt. LI was found in 81% of RAP children with abdominal pain most frequently, followed by nausea, bloating, diarrhea, borborygmi, and flatulence. Symp-tom onset occurred 30 minutes after lactose ingestion, especially nausea, bloating, and abdominal pain. In RAP children LI symptoms mostly found in breath hydrogen concentration>20 ppm. More LI symptoms were found in lactose malabsorbers, but symptoms were mild and generally disappeared in 7 hours, and in most by 15 hours.

  18. The attraction of virgin female hide beetles (Dermestes maculatus to cadavers by a combination of decomposition odour and male sex pheromones

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    von Hoermann Christian

    2012-08-01

    Full Text Available Abstract Introduction The hide beetle Dermestes maculatus (Coleoptera: Dermestidae feeds as an adult and larva on decomposing animal remains and can also be found on human corpses. Therefore, forensic entomological questions with regard to when and how the first receptive females appear on carcasses are important, as the developmental stages of their larvae can be used to calculate the post-mortem interval. To date, we know that freshly emerged males respond to the cadaver odour of post-bloated carcasses (approximately 9 days after death at Tmean = 27°C, being attracted by benzyl butyrate. This component occurs at its highest concentration at this stage of decay. The aim of our study was to determine the principle of attraction of virgin females to the feeding and breeding substrate. For this purpose, we tested the response of these females to headspace samples of piglet cadavers and male sex pheromones [(Z9-unsaturated fatty acid isopropyl esters] in a Y-olfactometer. Because we expected that such an odour combination is of importance for virgin female attraction, we tested the following two questions: 1 Are virgin female hide beetles attracted by a combination of cadaver odour and male sex pheromones? 2 During which decomposition stage do the first virgin females respond to cadaver odour when combined with male sex pheromones? Results We found that young virgin females were attracted to the cadaver by a combination of cadaver odour and male sex pheromones. Neither cadaver odour alone nor male sex pheromones alone was significantly more attractive than a solvent control. Our results also gave a weak indication that the first young virgin females respond as early as the post-bloating stage to its associated decomposition odour when combined with male sex pheromones. Conclusions Our results indicate that freshly emerged males possibly respond to cadaver odour and visit carcasses before virgin females. Being attracted to cadavers when male sex

  19. [Irritable Bowel Syndrome treatment: a multidisciplinary approach].

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    Shani-Zur, Dana; Wolkomir, Keren

    2015-01-01

    Irritable Bowel Syndrome affects 9-23% of the general population. This diagnosis contributes to more frequent doctor visits and multiple consultations by patients. The current approach to treating IBS is symptomatic and consists of a regimen of first line pharmacological treatment options; the use of anti-depressant drugs is also common. The efficiency of complementary medicine in the treatment of IBS has been studied in the last few years. Qualitative multidisciplinary approach studies, using personalized medicines with complementary therapies are needed. We present the case of a 39-year-old woman with a diagnosis of IBS since 2009, who complained about gastrointestinal symptoms since the age of 13 and severe episodes of spasmodic stomach aches in the last year self-ranked as 10, on a 0-10 scale; 3-4 episodes a month, which last for 5 days, accompanied by severe flatulence and bloating. In addition, she has constipation (one bowel movement every 10 days), alternating with multiple diarrheic bowel movements (6 times a day). Using a multidisciplinary approach, including medicinal care, Chinese medicine, reflexology and naturopathy resulted in significant improvement in symptoms and quality of life, as well as gradual reduction of drugs, approved by her physician. Stomach ache self-ranked now as 1, on a 0-10 scale; and flatulence and bloating self-ranked as mild. Bowel movement frequency increased and is now every other day. She no longer has diarrheic and/or multiple bowel movements. This case report emphasizes the importance of integrative treatment in IBS and its benefit in improving patients' quality of life.

  20. A pilot trial on subjects with lactose and/or oligosaccharides intolerance treated with a fixed mixture of pure and enteric-coated α- and ß-galactosidase

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    Di Pierro F

    2015-02-01

    Full Text Available Francesco Di Pierro,1 Alexander Bertuccioli,2 Eleonora Marini,3 Leandro Ivaldi4 1Velleja Research, Milan, Italy; 2Italian Association Fitness and Medicine, Fano, PU, Italy; 3Pharmextracta, Pontenure, Piacenza, Italy; 4Digestive Endoscopic Department, Ceva Hospital, Ceva, Cuneo, Italy Aim: Lactose and complex carbohydrates maldigestion, common food intolerances due to low gut content of α- and ß-galactosidase, lead to abdominal symptoms including pain, diarrhea, bloating, flatulence, and cramping. Commonly, intolerant patients are advised by physicians to avoid the offending foods (dairy foods, cereals, beans, etc. This food-limiting option, however, has possible nutritional risks. We have therefore evaluated the impact of using pure, enteric-coated α- plus ß-galactosidase on gut symptoms in intolerant subjects instead of avoidance of the offending foods. Methods: Sixteen subjects intolerant to lactose and/or complex carbohydrates were enrolled and evaluated in terms of gut symptoms with 1 uncontrolled diet, 2 diet devoid of offending foods, and 3 uncontrolled diet along with pure, enteric-coated α- and ß-galactosidase (DDM Galactosidase®. Results: Even with the uncontrolled diet, intolerant subjects treated with DDM Galactosidase® exhibited reduced gut symptoms (bloating, flatulence, diarrhea, and constipation significantly better than the control treatment as well as having a diet devoid of offending foods. Conclusion: DDM Galactosidase® is a valid and safe optional treatment to counteract lactose and complex carbohydrate intolerance in subjects who prefer not to avoid, at least partially, offending foods. Keywords: lactase, lactose intolerance, complex carbohydrate intolerance

  1. No significant association between halitosis and upper gastrointestinal endoscopic findings: a prospective study

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    Adnan Tas; Seyfettin K(o)klü; (I)lhami Yüksel; (O)mer Ba(s)ar; Erdem Akbal; Ahmet Cimbek

    2011-01-01

    Background Previous studies have focused on the relationship between halitosis,gastroesophageal reflux disease and Helicobacter pylori.In this study we aimed to investigate the interaction between halitosis and upper gastrointestinal endoscopic findings.Methods Patients who previously had dyspepsia and had undergone endoscopic examination were included in the study.Symptoms of dyspepsia were investigated by means of a questionnaire that investigated halitosis.Patients who suffered from objective halitosis (confirmed by questions both to the patient and their relatives) were further investigated.Patients with known local or systemic causes of halitosis or structural disorders at endoscopy were excluded.Results The study included 358 patients (121 men and 237 women) with dyspeptic symptoms.The patients with and without halitosis had mean ages of (39.4+13.5) and (43.1±14.9) years,respectively.Patients without halitosis were significantly older than those in the halitosis group (P <0.05).Patients in the halitosis group had significantly higher frequencies of regurgitation,bloating and nausea (P <0.05) when compared to patients without halitosis.Endoscopic findings,including esophagitis,open cardia,hiatal hernia,gastritis and duodenitis,were comparable in the two groups.Conclusions The frequency of halitosis was high in patients with dyspepsia who underwent upper gastrointestinal endoscopy.Halitosis had a close relationship with several upper gastrointestinal symptoms,including regurgitation,nausea and bloating.There was no significant association between upper gastrointestinal endoscopic findings and halitosis.

  2. Utility of the wireless motility capsule and lactulose breath testing in the evaluation of patients with Parkinson's disease who present with functional gastrointestinal symptoms

    Science.gov (United States)

    Su, Andrew; Gandhy, Rita; Barlow, Carrolee; Triadafilopoulos, George

    2017-01-01

    Background The aetiology and origin of gastrointestinal symptoms in Parkinson's disease (PD) remains poorly understood. Gastroparesis, small bowel transit delay and bacterial overgrowth may, individually or collectively, play a role. Aims In patients with PD and functional gastrointestinal symptoms, we aimed to determine the utility of the wireless motility capsule and lactulose breath tests in further defining their symptoms' aetiology. Methods In this retrospective cohort study, consecutive patients with PD and functional gastrointestinal symptoms underwent clinical assessment, as well as wireless motility capsule and lactulose breath testing using standard protocols. Results We studied 65 patients with PD and various gastrointestinal symptoms. 35% exhibited gastroparesis by the wireless motility capsule study, 20% small bowel transit delay, while 8% had combined transit abnormalities, suggestive of overlapping gastric and small bowel dysmotility. Small bowel bacterial overgrowth was seen in 34% of cases. Symptoms of abdominal pain, regurgitation, bloating, nausea, vomiting, belching and weight loss could not distinguish between patients with or without gastroparesis, although bloating was significantly more prominent (p<0.001) overall and specifically more so in patients with slow small bowel transit (p<0.01). There was no relationship between delayed small bowel transit time and bacterial overgrowth (p=0.5); PD scores and duration were not correlated with either the transit findings or small bowel bacterial overgrowth. Conclusions Functional gastrointestinal symptoms in patients with PD may reflect gastroparesis, small bowel transit delay or both, suggesting motor and/or autonomic dysfunction, and may be associated with small bowel bacterial overgrowth. The wireless motility capsule and lactulose breath testing are non-invasive and useful in the assessment of these patients.

  3. Association and symptom characteristics of irritable bowel syndrome among bronchial asthma patients in Kuwait

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    Panicker Radhakrishna

    2010-01-01

    Full Text Available Context : Excess prevalence of irritable bowel syndrome in asthma has been reported, suggesting a link between these two conditions. Aims: To investigate the association between irritable bowel syndrome (IBS and asthma, and explore the symptoms of IBS among asthma patients in Kuwait. Settings and Design: Case control study. Methods: In a tertiary center, for allergy and asthma, 138 patients aged 20-65 years, with asthma, diagnosed clinically and by spirometry,were compared with 145 healthy, non-asthmatic controls matched for age, gender and nationality. Cases and controls completed a self-administered questionnaire of irritable bowel syndrome diagnosis (ROME II criteria. Statistical Analysis Used: The data were analyzed using SPSS software, and proportions were tested with Chi-square or Fisher′s test. Odds ratio (OR with 95% Confidence Interval (CI were calculated to identify the associated risk factors. The demographic variables were selected for logistic regression analysis. Results : A significantly large proportion (39.13% of asthmatics had IBS as compared to 7.93% controls (P < 0.001. A higher proportion of females with IBS were observed in cases and controls (74%, 61.54%. IBS was seen in 87% cases using inhalers, and in 13% with additional oral theophylline (P < 0.001. As many as 66.6% cases, had IBS with relatively short duration of asthma (1-5 years, P < 000. Predominant symptoms of IBS in asthmatics were abdominal discomfort or distension (64.8% vs. 11.5%, (P < 0.000, OR = 14.1; 95%CI: 3.748-53.209, bloated feeling of abdomen (74.1% vs. 34.62% (P < 0.001, OR = 5.38; 95%CI:1.96-14.84, increased frequency of stools (63%, P < 0.006. Conclusions: Irritable bowel syndrome in asthmatics was significantly high, more in the female asthmatics. Abdominal discomfort, persistent bloated feeling, increased frequency of passing stools were the most common IBS symptoms observed.

  4. Functional results after repair of large hiatal hernia by use of a biologic mesh

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    Filimon eAntonakis

    2016-03-01

    Full Text Available Background: The aim of this observational study is to analyze the results of patients with large hiatal hernia and upside-down stomach after surgical closure with a biologic mesh (Permacol®, Covidien, Neustadt an der Donau, Germany. Biologic mesh is used to prevent long-term detrimental effects of artificial meshes and to reduce recurrence rates. Methods: A total of 13 patients with a large hiatal hernia and endothoracic stomach, who underwent surgery between 2010 and 2014, were included. Interviews and upper endoscopy were conducted to determine recurrence, lifestyle restrictions and current complaints. Results: After a mean follow-up of 26+18 months (range 3-58 months 10 patients (three men, mean age 73+13, range 26-81 years were evaluated. A small recurrent axial hernia was found in one patient postoperatively. Dysphagia was the most common complaint (four cases, while in one case the problem was solved after endoscopic dilatation. In three cases bloat and postprandial pain were documented. In one case explantation of the mesh was necessary due to mesh migration and painful adhesions. In one further case with gastroparesis pyloroplasty was performed without success.Conclusion: Recurrence was rare after hernia repair with the biologic mesh Permacol®. Dysphagia, gas bloat and intraabdominal pain were frequent complaints. Despite the small number of patients it can be concluded that a biologic mesh may be an alternative to synthetic meshes to reduce recurrences. Long-term results should be studied in the future in order to assess the potential of biologic meshes to preserve esophageal function as well. This is important since artificial meshes are known to erode the esophagus after 5–10 years.

  5. Menopausal complaints in Slovak midlife women and the impact of CYP1B1 polymorphism on their incidence.

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    Luptáková, Lenka; Sivtáková, Daniela; Cernanová, Veronika; Cvicelová, Marta

    2012-01-01

    A wide variety of symptoms have been attributed to menopause, negatively influencing women's physical and psychological health. In addition to lifestyle parameters and personal history, genetic factors are considered to be the main source of this variation. This study aims to investigate the incidence of menopausal symptoms among midlife women according to their menopausal status, and to evaluate the contribution to their manifestation from CYP1B1 Leu432Val polymorphism as a predisposing factor for menopausal symptoms. The studied cohort consisted of 299 women ranging from 39 to 59 years of age. Women were recruited from the western and middle parts of Slovakia, and all participants completed a menopause-specific questionnaire and provided blood or saliva samples for genotyping. Our results indicated that all women are at risk of typical menopausal symptoms, but there is a higher number of postmenopausal women affected than premenopausal ones. Regression analysis showed that the CYP1B1 Leu/Leu genotype can increase the experience of bloated stomach and facial hair increase in all the sampled women, while the Leu/Leu genotype may increase experience of palpitations and involuntary urination in the premenopausal women. The Leu/Leu genotype may increase the experience of nausea, bloated stomach, and vaginal dryness in peri- and postmenopausal women. We determined that women with the Leu/Leu, or Leu/Val genotypes were approximately five times more likely to suffer from vaginal dryness than the Val/Val women (OR = 4.948; 95% CI, 1.259-19.447). We therefore suggest that CYP1B1 Leu432Val polymorphism could be involved in individual susceptibility to menopausal symptoms in Slovak midlife women.

  6. Beetle succession and diversity between clothed sun-exposed and shaded pig carrion in a tropical dry forest landscape in Southern Mexico.

    Science.gov (United States)

    Caballero, Ubaldo; León-Cortés, Jorge L

    2014-12-01

    Over a 31-day period, the decomposition process, beetle diversity and succession on clothed pig (Sus scrofa L.) carcasses were studied in open (agricultural land) and shaded habitat (secondary forest) in Southern Mexico. The decomposition process was categorised into five stages: fresh, bloated, active decay, advanced decay and remains. Except for the bloated stage, the elapsed time for each decomposition stage was similar between open and shaded habitats, all carcasses reached an advanced decay stage in seven days, and the fifth stage (remains) was not recorded in any carcass during the time of this study. A total of 6344 beetles, belonging to 130 species and 21 families, were collected during the entire decomposition process, and abundances increased from fresh to advanced decay stages. Staphylinidae, Scarabaeidae and Histeridae were taxonomically and numerically dominant, accounting for 61% of the species richness and 87% of the total abundance. Similar numbers of species (87 and 88 species for open and shaded habitats, respectively), levels of diversity and proportions (open 49%; shaded 48%) of exclusive species were recorded at each habitat. There were significantly distinct beetle communities between habitats and for each stage of decomposition. An indicator species analysis ("IndVal") identified six species associated to open habitats, 10 species to shaded habitats and eight species to advanced decay stages. In addition, 23 beetle species are cited for the first time in the forensic literature. These results showed that open and shaded habitats both provide suitable habitat conditions for the carrion beetle diversity with significant differences in community structure and identity of the species associated to each habitat. This research provides the first empirical evidence of beetle ecological succession and diversity on carrion in Mexican agro-pastoral landscapes.

  7. High-fibre diet and Lactobacillus paracasei B21060 in symptomatic uncomplicated diverticular disease

    Institute of Scientific and Technical Information of China (English)

    Edith Lahner; Gianluca Esposito; Angelo Zullo; Cesare Hassan; Claudio Cannaviello; Maria Carla Di Paolo; Lorella Pallotta

    2012-01-01

    AIM:TO investigate in symptomatic uncomplicated diverticular disease the efficacy of symbiotics associated with a high-fibre diet on abdominal symptoms.METHODS:This study was a multicentre,6-mo randomized,controlled,parallel-group intervention with a preceding 4-wk washout period.Consecutive outpatients with symptomatic uncomplicated diverticular disease,aged 40-80 years,evaluated in 4 Gastroenterology Units,were enrolled.Symptomatic uncomplicated diverticular disease patients were randomized to two treatment arms A or B.Treatment A (n =24 patients)received 1 symbiotic sachet Flortec(c) (Lactobacillus paracasei B21060) once daily plus high-fibre diet for 6 mo.Treatment B (n =21 patients) received high-fibre diet alone for 6 mo.The primary endpoint was regression of abdominal symptoms and change of symptom severity after 3 and 6 mo of treatment.RESULTS:In group A,the proportion of patients with abdominal pain < 24 h decreased from 100% at baseline to 35% and 25% after 3 and 6 mo,respectively (P< 0.001).In group B the proportion of patients with this symptom decreased from 90.5% at baseline to 61.9% and 38.1% after 3 and 6 mo,respectively (P =0.001).Symptom improvement became statistically significant at 3 and 6 mo in group A and B,respectively.The proportion of patients with abdominal pain >24h decreased from 60% to 20% then 5% after 3 and 6 mo,respectively in group A (P < 0.001) and from 33.3% to 9.5% at both 3 and 6 mo in group B (P =0.03).In group A the proportion of patients with abdominal bloating significantly decreased from 95% to 60% after 3 mo,and remained stable (65%) at 6-mo follow-up (P =0.005) while in group B,no significant changes in abdominal bloating was observed (P =0.11).After 6 mo of treatment,the mean visual analogic scale (VAS) values of both short-lasting abdominal pain (VAS,mean ± SD,group A:4.6 ± 2.1 vs 2.2 ± 0.8,P =0.02;group B:4.6±2.9 vs 2.0 ± 1.9,P =0.03) and abdominal bloating (VAS,mean ± SD

  8. Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms

    Institute of Scientific and Technical Information of China (English)

    Kok-Sun Ho; Charmaine You Mei Tan; Muhd Ashik Mohd Daud; Francis Seow-Choen

    2012-01-01

    AIM:To investigate the effect of reducing dietary fiber on patients with idiopathic constipation.METHODS:Sixty-three cases of idiopathic constipation presenting between May 2008 and May 2010 were enrolled into the study after colonoscopy excluded an organic cause of the constipation.Patients with previous colon surgery or a medical cause of their constipation were excluded.All patients were given an explanation on the role of fiber in the gastrointestinal tract.They were then asked to go on a no fiber diet for 2 wk.Thereafter,they were asked to reduce the amount of dietary fiber intake to a level that they found acceptable.Dietary fiber intake,symptoms of constipation,difficulty in evacuation of stools,anal bleeding,abdominal bloating or abdominal pain were recorded at 1 and 6 mo.RESULTS:The median age of the patients (16 male,47 female) was 47 years (range,20-80 years).At 6 mo,41 patients remained on a no fiber diet,16 on a reduced fiber diet,and 6 resumed their high fiber diet for religious or personal reasons.Patients who stopped or reduced dietary fiber had significant improvement in their symptoms while those who continued on a high fiber diet had no change.Of those who stopped fiber completely,the bowel frequency increased from one motion in 3.75 d (± 1.59 d) to one motion in 1.0 d (± 0.0 d) (P < 0.001);those with reduced fiber intake had increased bowel frequency from a mean of one motion per 4.19 d (± 2.09 d)to one motion per 1.9 d (± 1.21 d) on a reduced fiber diet (P < 0.001); those who remained on a high fiber diet continued to have a mean of one motion per 6.83 d (± 1.03 d) before and after consultation.For no fiber,reduced fiber and high fiber groups,respectively,symptoms of bloating were present in 0%,31.3% and 100% (P < 0.001) and straining to pass stools occurred in 0%,43.8% and 100% (P < 0.001).CONCLUSION:Idiopathic constipation and its associated symptoms can be effectively reduced by stopping or even lowering the intake

  9. 大黄粉贴敷神阙穴治疗不完全性肠梗阻的临床研究%Clinical Study onDa Huang (Rheum Officinale) Powder Application at Shenque (CV 8) for Incomplete Intestinal Obstruction

    Institute of Scientific and Technical Information of China (English)

    喻明蕾

    2016-01-01

    Objective To observe the clinical efficacy ofDa Huang (Rheum Officinale) powder application at Shenque (CV 8) in treating incomplete intestinal obstruction.Method Fifty-eight patients with incomplete intestinal obstruction were randomized into a treatment group and a control group, 29 cases in each group. The control group was by enema with laxative medicine, while the treatment group was byDa Huang (Rheum Officinale) application at Shenque (CV 8) in addition to enema. The time of gassing and defecation, and abdominal bloating intensity were observed.Result The time of gassing and defecation and abdominal bloating intensity in the treatment group were significantly different from that in the control group (P<0.05).ConclusionDa Huang (Rheum Officinale) application at Shenque (CV 8) is an effective approach in treating incomplete intestinal obstruction.%目的:观察大黄粉贴敷神阙穴治疗不完全性肠梗阻的临床疗效。方法将58例不完全性肠梗阻患者随机分为治疗组和对照组,每组29例。对照组采用排便合剂灌肠治疗,治疗组在对照组基础上采用大黄粉贴敷神阙穴治疗。观察两组治疗后肛门排气时间、肛门排便时间及腹胀情况。结果治疗组治疗后肛门排气时间、肛门排便时间及腹胀情况与对照组比较,差异均具有统计学意义(P<0.05)。结论大黄粉贴敷神阙穴是一种治疗不完全性肠梗阻的有效方法。

  10. [Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].

    Science.gov (United States)

    Pilipenko, V I; Teplyuk, D A; Shakhovskaya, A K; Isakov, V A; Vorobyova, V M; Vorobyova, I S; Sarkisyan, V A; Kochetkova, A A; Mikheeva, G A; Yudina, A V

    2016-01-01

    Irritable bowel syndrome (IBS) is highly prevalent functional gastrointestinal disorder associated with decrease in quality of life and a high social cost. Diet is one of several therapeutic options in IBS treatment; therefore the development and clinical evaluation of innovative functional food for IBS patients are actual. Instant drink containing 4 g inulin, 4 mg menthol and 2 mg of pyridoxine (in daily dose) has been evaluated. 49 patients 18-68 (41.5±16.5) years old fulfilling the Rome III criteria for IBS-C were randomly assigned into two groups: one received standard diet plus two drinks per day for 2 weeks and control group received standard diet. Response to therapy was recorded daily using Likert scale of abdominal pain, bloating and feeling of incomplete bowel emptying, frequency of bowel movement, Bristol stool scale, and quality of life was assessed by IBSQoL questionnaire before and after the treatment. The consumption of the drink with inulin and menthol contributed to a significant positive effect on the stool parameters (from 0.91±0.73 to 1.12±0.45 bowel movements per day in stool frequency, p=0.05, from 2.68±1.63 to 3.43±1.27 index Bristol scale, p=0.05), reduced the severity of abdominal pain (from 1.78±0.58 to 1.47?0.61 Likert scale points, p=0.05), bloating (from 2.22±0.83 to 1.53±0.71 points ofLikertscale,p= 0.01) and a sense of incomplete bowelemptying (from 2.22 ± 0.88 to 1.61± 0.81 points of Likert scale, p=0.001), as well as increased the quality of life (from 75.3± 12.0 to 83.3±6.7%, p=0.05), but a significant part of patients (10 of 25) complained the appearance of heartburn after the start of the treatment. In conclusion, the consumption of the functional drink containing inulin, menthol and pyridoxine is associated with improve in stool parameters, abdominal pain, Bristol scale index and increase in quality of life in patients with IBS-C, but produce noticeable heartburn. Changes in functional drink composition are needed to

  11. Nucleotide supplementation: a randomised double-blind placebo controlled trial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449

    Directory of Open Access Journals (Sweden)

    Attree EA

    2006-06-01

    Full Text Available Abstract Background Dietary nucleotide supplementation has been shown to have important effects on the growth and development of cells which have a rapid turnover such as those in the immune system and the gastrointestinal tract. Work with infants has shown that the incidence and duration of diarrhoea is lower when nucleotide supplementation is given, and animal work shows that villi height and crypt depth in the intestine is increased as a result of dietary nucleotides. Dietary nucleotides may be semi-essential under conditions of ill-health, poor diet or stress. Since people with Irritable Bowel Syndrome tend to fulfil these conditions, we tested the hypothesis that symptoms would be improved with dietary nucleotide supplementation. Methods Thirty-seven people with a diagnosis of Irritable Bowel gave daily symptom severity ratings for abdominal pain, diarrhoea, urgency to have a bowel movement, incomplete feeling of evacuation after a bowel movement, bloating, flatulence and constipation for 28 days (baseline. They were then assigned to either placebo (56 days followed by experimental (56 days or the reverse. There was a four week washout period before crossover. During the placebo and experimental conditions participants took one 500 mg capsule three times a day; in the experimental condition the capsule contained the nutroceutical substances. Symptom severity ratings and psychological measures (anxiety, depression, illness intrusiveness and general health were obtained and analysed by repeated measures ANOVAs. Results Symptom severity for all symptoms (except constipation were in the expected direction of baseline>placebo>experimental condition. Symptom improvement was in the range 4 – 6%. A feeling of incomplete evacuation and abdominal pain showed the most improvement. The differences between conditions for diarrhoea, bloating and flatulence were not significant at the p Conclusion Dietary nucleotide supplementation improves some of the

  12. 中药保留灌肠配合穴位按摩对腹部术后胃肠功能恢复的疗效观察%Clinical Observation of TCM Retention Enema Combined with Acupressure Massage on Recovery of Gastrointestinal Function After Abdominal Surgery

    Institute of Scientific and Technical Information of China (English)

    刘均; 陈亮

    2015-01-01

    Abstracts:Objective To observe the effect of TCM retention enema combined with acupressure on the recovery of gastrointestinal func-tion after abdominal surgery.Methods 48 cases of abdominal surgery were randomly divided into two groups,the control group received rou-tine postoperative treatment,the treatment group were given TCM retention enema combined with acupressure therapy based on the control group.The clinical effect of two groups were compared.The recovery time of bowel sounds , flatus , defecation time , recovery time eating , bloating relief time and hospital stay in the two groups were recorded.Results The total effective rate in treatment group was higher than control group(P <0.05).The recovery time of bowel sounds , flatus , defecation , diet recovery,bloating relief and the hospital stay in treat-ment group were shorter than that of control group (P <0.05).Conclusion TCM retention enema combined with acupressure can promote the recovery of gastrointestinal function and improve the clinical efficacy after abdominal surgery.%目的:观察中药保留灌肠配合穴位按摩对腹部术后患者胃肠功能恢复的疗效。方法48例腹部手术患者随机分为两组。对照组给予常规术后处理,治疗组在对照组基础上给予中药保留灌肠配合穴位按摩治疗。比较两组临床疗效,记录两组肠鸣音恢复时间、肛门排气时间、排便时间、饮食恢复时间、腹胀缓解时间及住院天数。结果治疗组总有效率高于对照组(P <0.05);治疗组肠鸣音恢复时间、肛门排气时间、排便时间、饮食恢复时间、腹胀缓解时间及住院天数均短于对照组(P <0.05)。结论中药保留灌肠配合穴位按摩治疗能促进腹部术后患者肠功能恢复,提高临床疗效。

  13. Comparing the Effects of Yoga & Oral Calcium Administration in Alleviating Symptoms of Premenstrual Syndrome in Medical Undergraduates

    Directory of Open Access Journals (Sweden)

    Mehta Bharati

    2016-09-01

    Full Text Available Introduction: Medical undergraduates are heavily burdened by their curriculum. The females, in addition, suffer from vivid affective or somatic premenstrual syndrome (PMS symptoms such as bloating, mastalgia, insomnia, fatigue, mood swings, irritability, and depression. The present study was proposed to attenuate the symptoms of PMS by simple lifestyle measures like yoga and/or oral calcium. Methods: 65 medical female students (18-22 years with a regular menstrual cycle were asked to self-rate their symptoms, along with their severity, in a validated questionnaire for two consecutive menstrual cycles. Fifty-eight students were found to have PMS. Twenty girls were given yoga training (45 minutes daily, five days a week, for three months. Another group of 20 was given oral tablets of calcium carbonate daily (500 mg, for three months and rest 18 girl served as control group. Data were analyzed by SPSS ver.13 software. Results: The yoga and calcium groups showed a significant decrease in number and severity of premenstrual symptoms whereas in the control group there was not the significant difference. Conclusion: Encouraging a regular practice of yoga or taking a tablet of calcium daily in the medical schools can decrease the symptoms of premenstrual syndrome.

  14. Comparing the Effects of Yoga & Oral Calcium Administration in Alleviating Symptoms of Premenstrual Syndrome in Medical Undergraduates.

    Science.gov (United States)

    Bharati, Mehta

    2016-09-01

    Introduction: Medical undergraduates are heavily burdened by their curriculum. The females, in addition, suffer from vivid affective or somatic premenstrual syndrome (PMS) symptoms such as bloating, mastalgia, insomnia, fatigue, mood swings, irritability, and depression. The present study was proposed to attenuate the symptoms of PMS by simple lifestyle measures like yoga and/or oral calcium. Methods: 65 medical female students (18-22 years) with a regular menstrual cycle were asked to self-rate their symptoms, along with their severity, in a validated questionnaire for two consecutive menstrual cycles. Fifty-eight students were found to have PMS. Twenty girls were given yoga training (45 minutes daily, five days a week, for three months). Another group of 20 was given oral tablets of calcium carbonate daily (500 mg, for three months) and rest 18 girl served as control group. Data were analyzed by SPSS ver.13 software. Results: The yoga and calcium groups showed a significant decrease in number and severity of premenstrual symptoms whereas in the control group there was not the significant difference. Conclusion: Encouraging a regular practice of yoga or taking a tablet of calcium daily in the medical schools can decrease the symptoms of premenstrual syndrome.

  15. The environment of the strongest galactic methanol maser

    CERN Document Server

    Sanna, A; Carrasco-Gonzalez, C; Reid, M J; Ellingsen, S P; Brunthaler, A; Moscadelli, L; Cesaroni, R; Krishnan, V

    2015-01-01

    The high-mass star-forming site G009.62-00.20E hosts the 6.7 GHz methanol maser source with the greatest flux density in the Galaxy which has been flaring periodically over the last ten years. We performed high-resolution astrometric measurements of the CH3OH, H2O, and OH maser emission and 7 mm continuum in the region. The radio continuum emission was resolved in two sources separated by 1300 AU. The CH3OH maser cloudlets are distributed along two north-south ridges of emission to the east and west of the strongest radio continuum component. This component likely pinpoints a massive young stellar object which heats up its dusty envelope, providing a constant IR pumping for the Class II CH3OH maser transitions. We suggest that the periodic maser activity may be accounted for by an independent, pulsating, IR radiation field provided by a bloated protostar in the vicinity of the brightest masers. We also report about the discovery of an elliptical distribution of CH3OH maser emission in the region of periodic v...

  16. Parasites in Mexican patients with irritable bowel syndrome: a case-control study

    Directory of Open Access Journals (Sweden)

    Gonzalez-Angulo Alberto

    2010-10-01

    Full Text Available Abstract One hundred and fifteen patients with symptoms suggestive of irritable bowel syndrome (IBS according to Rome III criteria and 209 patients with gastrointestinal symptoms different from IBS (control were identified through medical records from the Gastroenterology Clinic of the "Dr. Manuel Gea Gonzalez General Hospital" from January 2008 to March 2010. No statistical differences in IBS data as compared with control groups were observed except in bloating, that was more frequent in the IBS group (P = 0.043. Although the pathogenicity of specific intestinal protozoa could not be demonstrated due to lack of association with the development of gastrointestinal symptoms, Blastocystis spp, in the IBS group, exhibited a trend of association to diarrhoea (odds ratio = 2.73, 95% confidence interval = 0.84-8.80, P = 0.053, while having any parasite and diarrhoea was significant (odds ratio = 3.38, 95% confidence interval = 1.33-8.57, P = 0.008. The association between Blastocystis and diarrhoea in IBS patients although not conclusive is an interesting finding; nonetheless more extensive case-controlled studies are required to clearly define the role of some "non-pathogenic" parasites in intestinal disease and IBS.

  17. Impact of volcanic plume emissions on rain water chemistry during the January 2010 Nyamuragira eruptive event: implications for essential potable water resources.

    Science.gov (United States)

    Cuoco, Emilio; Tedesco, Dario; Poreda, Robert J; Williams, Jeremy C; De Francesco, Stefano; Balagizi, Charles; Darrah, Thomas H

    2013-01-15

    On January 2, 2010 the Nyamuragira volcano erupted lava fountains extending up to 300 m vertically along an ~1.5 km segment of its southern flank cascading ash and gas on nearby villages and cities along the western side of the rift valley. Because rain water is the only available potable water resource within this region, volcanic impacts on drinking water constitutes a major potential hazard to public health within the region. During the 2010 eruption, concerns were expressed by local inhabitants about water quality and feelings of physical discomfort (e.g. nausea, bloating, indigestion, etc.) after consuming rain water collected after the eruption began. We present the elemental and ionic chemistry of drinking water samples collected within the region on the third day of the eruption (January 5, 2010). We identify a significant impact on water quality associated with the eruption including lower pH (i.e. acidification) and increases in acidic halogens (e.g. F(-) and Cl(-)), major ions (e.g. SO(4)(2-), NH(4)(+), Na(+), Ca(2+)), potentially toxic metals (e.g. Al(3+), Mn(2+), Cd(2+), Pb(2+), Hf(4+)), and particulate load. In many cases, the water's composition significantly exceeds World Health Organization (WHO) drinking water standards. The degree of pollution depends upon: (1) ash plume direction and (2) ash plume density. The potential negative health impacts are a function of the water's pH, which regulates the elements and their chemical form that are released into drinking water.

  18. Mineralogy and microstructure of sintered lignite coal fly ash

    Energy Technology Data Exchange (ETDEWEB)

    Marina Ilic; Christopher Cheeseman; Christopher Sollars; Jonathan Knight [Faculty of Technology and Metallurgy, Belgrade (Yugoslavia)

    2003-02-01

    Lignite coal fly ash from the 'Nikola Tesla' power plant in Yugoslavia has been characterised, milled, compacted and sintered to form monolithic ceramic materials. The effect of firing at temperatures between 1130 and 1190{sup o}C on the density, water accessible porosity, mineralogy and microstructure of sintered samples is reported. This class C fly ash has an initial average particle size of 82 {mu}m and contains siliceous glass together with the crystalline phases quartz, anorthite, gehlenite, hematite and mullite. Milling the ash to an average particle size of 5.6 m, compacting and firing at 1170{sup o}C for 1 h produces materials with densities similar to clay-based ceramics that exhibit low water absorption. Sintering reduces the amount of glass, quartz, gehlenite and anhydrite, but increases formation of anorthite, mullite, hematite and cristobalite. SEM confirms the formation of a dense ceramic at 1170{sup o}C and indicates that pyroplastic effects cause pore formation and bloating at 1190{sup o}C. 23 refs., 6 figs., 2 tabs.

  19. A case report of incisional hernia through a 5 mm lateral port site following laparoscopic cholecystectomy

    Directory of Open Access Journals (Sweden)

    Audrius Dulskas

    2011-01-01

    Full Text Available Introduction: Less than 10 mm port-site herniation is a rare complication after laparoscopic surgery. We report a case of complicated herniation through the 5-mm lateral trocar port site. Case Report: A 63-year old obese female was admitted due to intestinal obstruction. She has undergone the laparoscopic cholecystectomy 1 year ago. On examination, abdomen was bloated and roughly 10 cm size mass was palpable on the right subcostal area. Plane radiogram of the abdomen showed signs of intestinal obstruction. Since conservative treatment was ineffective, the patient was operated on. The laparotomy revealed a protrusion of a part of right large intestine and greater omentum into the subcutaneous space through the abdominal wall defect below right subcostal margin. There was a dilatation of intestines proximally incarcerated colon. It was released and a part of omentum was resected. The peritoneum and fascia-muscular defect was closed by interrupted vicryl sutures. Conclusion: Acute herniation through a 5 mm size most lateral trocar port site is a rare complication of laparoscopic surgery requiring prompt differential diagnosis.

  20. [ORAL CONTRACEPTIVES AND MOOD/SEXUAL DISORDERS IN WOMEN].

    Science.gov (United States)

    Sirakov, M; Tomova, E

    2015-01-01

    Oral contraceptives are used since more than 50 years and are very popular due to offering more than 99% confidence in preventing pregnancy. Over 100 million women worldwide use oral contraceptives. In the UK 27% of women between 16 and 49 y. use pills. In the United States they are about 30%, in Germany - 40%, and in The Netherlands - 60%. According to a study by B. Pehlivanov, 2008, in Bulgaria only 4% of women use OC. (1) Despite the convenience and security, in the U.S.A. 29% of women taking OC interrupt prematurely their use (2), while the percentage of adolescents appears to be higher (3) Earlier studies of the reasons for refusal of OC focus on their influence on the menstrual cycle, as well as on some physical side effects such as the appearance of hair growth, weight gain, bloating etc. They paid very little attention to their impact on mood and sexual behavior of women (4). Newer studies suggest that the side effects associated with mood and sexual behavior proved more powerful factor leading to early termination of the use of OC (5). This paper is a review of the literature and evaluation of the facts presented in studies from different countries. They found a high incidence of symptoms such as anxiety, susceptibility to stress, mood changes, incl. depression, anxiety, increased irritability and affection of sexual desire of women. (6) There are many indications that OC-users are at increased risk of suicide and mental illnesses. (9).

  1. Medical image of the week: splenic infarction

    Directory of Open Access Journals (Sweden)

    Casey DJ

    2016-08-01

    Full Text Available No abstract available. Article truncated after 150 words. A 52-year-old Hispanic woman with a past medical history significant for Type 1 Diabetes Mellitus, hypertension, and rheumatoid arthritis presented with left upper quadrant pain for one day. Her review of systems was positive for bloating, severe epigastric and left upper quadrant tenderness that radiated to the back and left shoulder, nausea with non-bilious emesis, and diarrhea for one day prior to admission. Physical exam only revealed epigastric and left upper quadrant tenderness to light palpation without rebound or guarding. Abdominal computed tomography of the abdomen demonstrated a new acute or subacute splenic infarct with no clear evidence of an embolic source in the abdomen or pelvis (Figure 1. Echocardiogram with bubble study and contrast did not demonstrate valve abnormalities, cardiac mass, vegetation, valve or wall motion abnormalities and no evidence of patent foramen ovale. Splenic infarction should be suspected when patients present with sharp, acute left upper quadrant pain ...

  2. May 2016 critical care case of the month

    Directory of Open Access Journals (Sweden)

    Al-Jashaami L

    2016-05-01

    Full Text Available No abstract available. Article truncated after first 150 words. History of Present Illness: A 50-year-old African American woman presented with weakness, altered mental status and constipation of 12 days duration. She was complaining of abdominal distension with diffuse pain and bloating. She denied melena, hematochezia or hematemesis. She had a history weight loss, anorexia and fatigue which had evolved over the past few months leading to recent severe weakness and inability to get out of bed. Past Medical History, Social History and Family History: Her past medical history included HIV infection with AIDS and noncompliance with her antiretroviral medications. Her most recent CD4 count was <20 cells/uL and viral load of 554,483 copies/mL. Physical Examination: Vital signs: Blood pressure, 120/80 mmHg, heart rate, 105/min, temperature, 98.6° and respiratory rate, 20/min. General: Physical examination showed a lethargic female who was poorly responsive to questioning. Abdomen: Distended, tympanic abdomen with hypoactive bowel sounds and diffuse tenderness. Radiography: Plain x-ray examination of ...

  3. Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

    Science.gov (United States)

    Gu, Lili; Ding, Chao; Tian, Hongliang; Yang, Bo; Zhang, Xuelei; Hua, Yue; Zhu, Yifan; Gong, Jianfeng; Zhu, Weiming; Li, Jieshou; Li, Ning

    2017-01-01

    Background/Aims Chronic intestinal pseudo-obstruction (CIPO) is a serious, life-threatening motility disorder that is often related to bacterial overgrowth. Fecal microbiota transplantation (FMT) results in restoration of the normal intestinal microbial community structure. We investigated the efficacy of FMT in the treatment of CIPO patients. Methods Nine patients (age 18–53 years) with CIPO were enrolled in this prospective, open-label study. Patients received FMT for 6 consecutive days through nasojejunal (NJ) tubes and were followed up for 8 weeks after treatment. We evaluated the rate of clinical improvement and remission, feeding tolerance of enteral nutrition, and CT imaging scores of intestinal obstructions. Lactulose hydrogen breath tests were performed before FMT and 8 weeks after FMT to evaluate for the presence small intestinal bacterial overgrowth (SIBO). Results FMT significantly alleviated bloating symptoms, and symptoms of pain were relieved 2 weeks after FMT. Enteral nutrition administered through a NJ tube after FMT was well-tolerated by 66.7% (6/9) of patients. CT scores of intestinal obstructions were significantly reduced after FMT (P = 0.014). SIBO was eliminated in 71.0% (5/7) of patients. Conclusions This pilot study demonstrated the safety of using FMT. FMT may relieve symptoms in selected patients with CIPO. FMT may also improve patient tolerance of enteral nutrition delivered via a NJ tube. PMID:27840368

  4. Addition of senna improves quality of colonoscopy preparation with magnesium citrate

    Institute of Scientific and Technical Information of China (English)

    Stergios Vradelis; Evangelos Kalaitzakis; Yalda Sharifi; Otto Buchel; Satish Keshav; Roger W Chapman; Barbara Braden

    2009-01-01

    AIM: To prospectively investigate the effectiveness and patient's tolerance of two low-cost bowel cleansing preparation protocols based on magnesium citrate only or the combination of magnesium citrate and senna. METHODS: A total of 342 patients who were referred for colonoscopy underwent a colon cleansing protocol with magnesium citrate alone ( n = 160) or magnesium citrate and senna granules ( n = 182). The colonoscopist rated the overall efficacy of colon cleansing using an established score on a 4-point scale. Patients were questioned before undergoing colonoscopy for side effects and symptoms during bowel preparation. RESULTS: The percentage of procedures rescheduled because of insufficient colon cleansing was 7% in the magnesium citrate group and 4% in the magnesium citrate/senna group ( P = 0.44). Adequate visualization of the colonic mucosa was rated superior under the citramag/senna regimen ( P = 0.004). Both regimens were well tolerated, and did not significantly differ in the occurrence of nausea, bloating or headache. However, abdominal cramps were observed more often under the senna protocol (29.2%) compared to the magnesium citrate only protocol (9.9%, P < 0.0003). CONCLUSION: The addition of senna to the bowel preparation protocol with magnesium citrate significantly improves the cleansing outcome.

  5. A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature

    Science.gov (United States)

    Tang, Chen; Scaramangas-Plumley, Daphne; Nast, Cynthia C.; Mosenifar, Zab; Edelstein, Marc A.; Weisman, Michael

    2017-01-01

    Patient: Male, 73 Final Diagnosis: Henoch-Schönlein purpura (HSP) Symptoms: Abdominal pain • bloating • blood in stool • nausea • vomiting Medication: — Clinical Procedure: EGD • colonoscopy • kidney biopsy • skin biopsy • arthrocentesis Specialty: Rheumatology Objective: Unknown ethiology Background: Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint pain, and hematuria. The disease most commonly targets children but can affect adults who tend to have a worse prognosis. Case Report: We discuss a case of HSP in an elderly Chinese male who presented with severe proximal bowel inflammation, vasculitic rash, and proteinuria; he was found to have positive stool rotavirus and giardia. He improved significantly with high dose steroids. We believe rotavirus may have been a triggering event in this patient. A brief review of the literature is also presented. Conclusions: This is the first case report describing a classic presentation of HSP in an adult following a rotavirus infection. HSP can cause significant morbidity and mortality in adult patients predominantly from progressive renal failure; therefore careful management and monitoring is important. GI infections seem to be a common trigger for HSP and this case report suggests that rotavirus may be part of the spectrum. PMID:28174414

  6. Curcumin ameliorates gastrointestinal dysfunction and oxidative damage in diabetic rats

    Directory of Open Access Journals (Sweden)

    Nitin Indarchandji Kochar

    2014-05-01

    Full Text Available Diabetes is known to be associated with gastrointestinal complications characterized by nausea, vomiting, early satiety, bloating, and abdominal discomfort or pain commonly occurring in the advanced stages of the disease. Curcumin is the lipid-soluble antioxidant obtained from the rhizomes of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and oxidative stress pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, literature lacks conclusive evidence supporting its use as a therapeutic agent for the treatment of diabetes induced gastrointestinal complications. Hence, Curcumin was given in different doses to SD rats after 4 weeks of diabetic GI complication induction. At the end of 4 weeks, significant GI dysfunction characterized by weight loss, delayed gastric emptying and intestinal transit associated with reduction in antioxidant enzyme levels and increased lipid peroxidation was observed.  Upon treatment with Curcumin for further 4 weeks, reversal of GI dysfunction evidenced by restoration of body weight, GI emptying, intestinal transit, and restoration of antioxidant enzyme level and lipid peroxidation proves the beneficial role of Curcumin in diabetes induced GI complications due to its antioxidant potential.     

  7. Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?

    Science.gov (United States)

    O'Malley, Dervla; Quigley, Eamonn M M; Dinan, Timothy G; Cryan, John F

    2011-10-01

    Irritable bowel syndrome (IBS) is a common, debilitating gastrointestinal (GI) disorder, with a worldwide prevalence of between 10% and 20%. This functional gut disorder is characterized by episodic exacerbations of a cluster of symptoms including abdominal pain, bloating and altered bowel habit, including diarrhea and/or constipation. Risk factors for the development of IBS include a family history of the disorder, childhood trauma and prior gastrointestinal infection. It is generally accepted that brain-gut axis dysfunction is fundamental to the development of IBS; however the underlying pathophysiological mechanisms remain elusive. Additional considerations in comprehending the chronic relapsing pattern that typifies IBS symptoms are the effects of both psychosocial and infection-related stresses. Indeed, co-morbidity with mood disorders such as depression and anxiety is common in IBS. Accumulating evidence points to a role for a maladaptive stress response in the initiation, persistence and severity of IBS-associated symptom flare-ups. Moreover, mechanistically, the stress-induced secretion of corticotropin-releasing factor (CRF) is known to mediate changes in GI function. Activation of the immune system also appears to be important in the generation of IBS symptoms and increasing evidence now implicates low-grade inflammation or immune activation in IBS pathophysiology. There is a growing body of research focused on understanding at a molecular, cellular and in vivo level, the relationship between the dysregulated stress response and immune system alterations (either individually or in combination) in the etiology of IBS and to the occurrence of symptoms.

  8. Barber Pole Sign in CT Angiography, Adult Presentation of Midgut Malrotation: A Case Report

    Directory of Open Access Journals (Sweden)

    Garcelan-Trigo

    2015-07-01

    Full Text Available Adult midgut volvulus is a challenging diagnosis because of its low incidence and nonspecific symptoms. Diagnostic delay and long-term complaints are frequent in this clinical scenario. We reported a patient referred to our diagnostic imaging unit with intermittent abdominal pain, bloating and episodic vomiting for several years. He underwent barium gastrointestinal transit and abdominal ultrasound, which revealed severe gastric dilatation, food retention and slow transit until a depressed duodenojejunal flexure, with malrotation of the midgut and jejunal loops being located in the right upper quadrant. Computed tomography angiography was performed, showing rotation of the small intestine around the mesentery root, suggestive of midgut malrotation. In addition, an abnormal twisted disposition of superior mesenteric artery with corkscrew appearance was seen, shaping the pole-barber sign which was evident in volume rendering three-dimensional reconstructions. The patient underwent scheduled surgical treatment without any complication and had good outcome after hospital discharge and follow-up. Computed tomography plays an important role in evaluation of adult midgut volvulus. In addition, angiographic reconstructions can help us to assess the anatomic disposition of mesenteric vascular supply. Both of these assessments are useful in preoperative management.

  9. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: Experience with Rifaximin

    Institute of Scientific and Technical Information of China (English)

    Sergio Peralta; Claudia Cottone; Tiziana Doveri; Piero Luigi Almasio; Antonio Craxi

    2009-01-01

    AIM: To estimate the prevalence of small intestinal bacterial overgrowth (SIBO) in our geographical area (Western Sicily, Italy) by means of an observational study, and to gather information on the use of locally active, nonabsorbable antibiotics for treatment of SIBO. METHODS: Our survey included 115 patients fulfilling the Rome Ⅱ criteria for diagnosis of irritable bowel syndrome (IBS); a total of 97 patients accepted to perform a breath test with lactulose (BTLact), and those who had a positive test, received Rifaximin (Normix., Alfa Wassermann) 1200 mg/d for 7 d; 3 wk after the end of treatment, the BTLact was repeated. RESULTS: Based on the BTLact results, SIBO was present in about 56% of IBS patients, and it was responsible for some IBSrelated symptoms, such as abdominal bloating and discomfort, and diarrhoea. 1wktreatment with Rifaximin turned the BTLact to negative in about 50% of patients and significantly reduced the symptoms, especially in those patients with an alternated constipation/diarrhoeavariant IBS.CONCLUSION: SIBO should be always suspected in patients with IBS, and a differential diagnosis is done by means of a"breath test". Rifaximin may represent a valid approach to the treatment of SIBO.

  10. Participatory surveillance of livestock and poultry diseases in Agidi development area of Nasarawa state Nigeria

    Directory of Open Access Journals (Sweden)

    Victor Haruna

    2012-08-01

    Full Text Available A participatory surveillance of livestock and poultry diseases was carried out in Agidi Development Area of Nasarawa State among 123 farmers, 29 of the respondent were female, while 94 were male. Open-ended interviews were utilized where necessary to clarify information that needed clarifications by the respondents; physical examination of the some affected animals and it surroundings were carried out during the surveillance. The following diseases were established in the study area: Peste des peptits ruminants, Foot rot, helminthosis, mite/lice/flea infestation, tick infestation, bloat, Orf (Contagious ecthyma, poison, mange, Newcastle disease, fowl pox, coccidiosis, infectious bursal disease (Gumboro, chronic respiratory disease, African Swine Fever (ASF, abortion, Dystocia, sudden death, foot and mouth disease, Fascioliasis, trypanosomosis, black quarter disease, babesiosis, and wounds. Some of these diseases have specific period (season of outbreak, while some occurs at all season. Analysis of data indicated that Newcastle disease was the most important disease of poultry, Peste des peptits ruminants was the disease that lead to high mortality in small ruminants, while African Swine Fever (ASF is the most devastating disease of pigs, and Lice/flea infestation is the most common disease to poultry, small ruminants and pigs, in the study area.

  11. Oats induced villous atrophy in coeliac disease

    Science.gov (United States)

    Lundin, K E A; Nilsen, E M; Scott, H G; Løberg, E M; Gjøen, A; Bratlie, J; Skar, V; Mendez, E; Løvik, A; Kett, K

    2003-01-01

    The current trend is to allow coeliac disease (CD) patients to introduce oats to their gluten free diet. We sought further data from the clinical setting with regards to oats consumption by coeliac patients. Several oat products were tested for wheat contamination using a commercial enzyme linked immunoassay (ELISA) kit, and six samples were examined by an ELISA using a cocktail of monoclonal antibodies, mass spectrometry, and western blot analysis. Nineteen adult CD patients on a gluten free diet were challenged with 50 g of oats per day for 12 weeks. Serological testing and gastroduodenoscopy was performed before and after the challenge. Biopsies were scored histologically and levels of mRNA specific for interferon γ were determined by reverse transcription-polymerase chain reaction analysis. Oats were well tolerated by most patients but several reported initial abdominal discomfort and bloating. One of the patients developed partial villous atrophy and a rash during the first oats challenge. She subsequently improved on an oats free diet but developed subtotal villous atrophy and dramatic dermatitis during a second challenge. Five of the patients showed positive levels of interferon γ mRNA after challenge. Some concerns therefore remain with respect to the safety of oats for coeliacs. PMID:14570737

  12. Recommended patient-reported core set of symptoms and quality-of-life domains to measure in ovarian cancer treatment trials.

    Science.gov (United States)

    Donovan, Kristine A; Donovan, Heidi S; Cella, David; Gaines, Martha E; Penson, Richard T; Plaxe, Steven C; von Gruenigen, Vivian E; Bruner, Deborah Watkins; Reeve, Bryce B; Wenzel, Lari

    2014-07-01

    There is no consensus as to what symptoms or quality-of-life (QOL) domains should be measured as patient-reported outcomes (PROs) in ovarian cancer clinical trials. A panel of experts convened by the National Cancer Institute reviewed studies published between January 2000 and August 2011. The results were included in and combined with an expert consensus-building process to identify the most salient PROs for ovarian cancer clinical trials. We identified a set of PROs specific to ovarian cancer: abdominal pain, bloating, cramping, fear of recurrence/disease progression, indigestion, sexual dysfunction, vomiting, weight gain, and weight loss. Additional PROs identified in parallel with a group charged with identifying the most important PROs across cancer types were anorexia, cognitive problems, constipation, diarrhea, dyspnea, fatigue, nausea, neuropathy, pain, and insomnia. Physical and emotional domains were considered to be the most salient domains of QOL. Findings of the review and consensus process provide good support for use of these ovarian cancer-specific PROs in ovarian cancer clinical trials.

  13. [Functional gastrointestinal disorders].

    Science.gov (United States)

    Vogt, W

    2007-11-21

    Functional gastrointestinal disorders particularly dyspepsia an irritable bowel syndrome are frequent problems for the general practitioner and also for the specialist. Both are diseases and not only a kind of discomfort. The high frequency of dispepsia and irritable bowel syndrome induces very high direct and indirect charges. Both diseases depend on a number of factors or causes, for whom the evidence is not good. But there are good experimental data for the visceral hypersensitivity as one of the main factors. Gastroscopy is the most important examination in the diagnosis of dyspepsia. Endoscopy has to be done in all patients with alarm symptoms an in all patients older than 45 years. The therapy of dyspepsia is an empirical one. The eradication of Helicobacter pylori is a therapeutical option, but only 8% of the patients will have benefit for a long time. Other therapeutical options are the use of proton-pump inhibitors, prokinetics or phytotherapeutics. The therapy of the irritable bowel syndrome depends on the subtype of the disease (diarrhea, constipation, abdominal pain, bloating). First of all a good doctor-patient relationship is mandatory. Furthermore the use of dietary fibre, antidiarrhoeics, laxatives and muscle relaxants may be beneficial. And phytotherapeutics can be an additional therapeutic approach.

  14. Buffer management in wireless full-duplex systems

    KAUST Repository

    Bouacida, Nader

    2015-10-19

    Wireless full-duplex radios can simultaneously transmit and receive using the same frequency. In theory, this can double the throughput. In fact, there is only little work addressing aspects other than throughput gains in full-duplex systems. Over-buffering in today\\'s networks or the so-called “bufferbloat” phenomenon creates excessive end-to-end delays resulting in network performance degradation. Our analysis shows that full-duplex systems may suffer from high latency caused by bloated buffers. In this paper, we address the problem of buffer management in full-duplex networks by using Wireless Queue Management (WQM), which is an active queue management technique for wireless networks. Our solution is based on Relay Full-Duplex MAC (RFD-MAC), an asynchronous media access control protocol designed for relay full-duplexing. We compare the performance of WQM in full-duplex environment to Drop Tail mechanism over various scenarios. Our solution reduces the end-to-end delay by two orders of magnitude while achieving similar throughput in most of the cases.

  15. Prevalence and Characterization of Self-Reported Gluten Sensitivity in The Netherlands

    Directory of Open Access Journals (Sweden)

    Tom van Gils

    2016-11-01

    Full Text Available Background: A growing number of individuals reports symptoms related to the ingestion of gluten-containing food in the absence of celiac disease. Yet the actual prevalence is not well established. Methods: Between April 2015 and March 2016, unselected adults visiting marketplaces, dental practices and a university in The Netherlands were asked to complete a modified validated questionnaire for self-reported gluten sensitivity (srGS. Results: Among the 785 adults enquired, two had celiac disease. Forty-nine (6.2% reported symptoms related to the ingestion of gluten-containing food. These individuals were younger, predominantly female and lived more frequently in urban regions compared with the other respondents. Symptoms reported included bloating (74%, abdominal discomfort (49% and flatulence (47%. A total of 23 (47% srGS individuals reported having had tried a gluten-free or gluten-restricted diet. Abdominal discomfort related to fermentable oligosaccharide, disaccharide, monosaccharide and polyol (FODMAP-containing food was more often reported in srGS individuals compared with the other respondents (73.5% vs. 21.7%, p < 0.001. Conclusion: Self-reported GS is common in The Netherlands, especially in younger individuals, females and urban regions, although the prevalence was lower than in a comparable recent UK study. It cannot be excluded that FODMAPs are in part responsible for these symptoms.

  16. Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?

    Science.gov (United States)

    De Giorgio, Roberto; Volta, Umberto; Gibson, Peter R

    2016-01-01

    IBS is one of the most common types of functional bowel disorder. Increasing attention has been paid to the causative role of food in IBS. Food ingestion precipitates or exacerbates symptoms, such as abdominal pain and bloating in patients with IBS through different hypothesised mechanisms including immune and mast cell activation, mechanoreceptor stimulation and chemosensory activation. Wheat is regarded as one of the most relevant IBS triggers, although which component(s) of this cereal is/are involved remain(s) unknown. Gluten, other wheat proteins, for example, amylase-trypsin inhibitors, and fructans (the latter belonging to fermentable oligo-di-mono-saccharides and polyols (FODMAPs)), have been identified as possible factors for symptom generation/exacerbation. This uncertainty on the true culprit(s) opened a scenario of semantic definitions favoured by the discordant results of double-blind placebo-controlled trials, which have generated various terms ranging from non-coeliac gluten sensitivity to the broader one of non-coeliac wheat or wheat protein sensitivity or, even, FODMAP sensitivity. The role of FODMAPs in eliciting the clinical picture of IBS goes further since these short-chain carbohydrates are found in many other dietary components, including vegetables and fruits. In this review, we assessed current literature in order to unravel whether gluten/wheat/FODMAP sensitivity represent 'facts' and not 'fiction' in IBS symptoms. This knowledge is expected to promote standardisation in dietary strategies (gluten/wheat-free and low FODMAP) as effective measures for the management of IBS symptoms.

  17. Irritable bowel syndrome: new insights into symptom mechanisms and advances in treatment.

    Science.gov (United States)

    Spiller, Robin

    2016-01-01

    Despite being one of the most common conditions leading to gastroenterological referral, irritable bowel syndrome (IBS) is poorly understood. However, recent years have seen major advances. These include new understanding of the role of both inflammation and altered microbiota as well as the impact of dietary intolerances as illuminated by magnetic resonance imaging (MRI), which has thrown new light on IBS. This article will review new data on how excessive bile acid secretion mediates diarrhea and evidence from post infectious IBS which has shown how gut inflammation can alter gut microbiota and function. Studies of patients with inflammatory bowel disease (IBD) have also shown that even when inflammation is in remission, the altered enteric nerves and abnormal microbiota can generate IBS-like symptoms. The efficacy of the low FODMAP diet as a treatment for bloating, flatulence, and abdominal discomfort has been demonstrated by randomized controlled trials. MRI studies, which can quantify intestinal volumes, have provided new insights into how FODMAPs cause symptoms. This article will focus on these areas together with recent trials of new agents, which this author believes will alter clinical practice within the foreseeable future.

  18. Prevalence and Characterization of Self-Reported Gluten Sensitivity in The Netherlands

    Science.gov (United States)

    van Gils, Tom; Nijeboer, Petula; IJssennagger, Catharina E.; Sanders, David S.; Mulder, Chris J. J.; Bouma, Gerd

    2016-01-01

    Background: A growing number of individuals reports symptoms related to the ingestion of gluten-containing food in the absence of celiac disease. Yet the actual prevalence is not well established. Methods: Between April 2015 and March 2016, unselected adults visiting marketplaces, dental practices and a university in The Netherlands were asked to complete a modified validated questionnaire for self-reported gluten sensitivity (srGS). Results: Among the 785 adults enquired, two had celiac disease. Forty-nine (6.2%) reported symptoms related to the ingestion of gluten-containing food. These individuals were younger, predominantly female and lived more frequently in urban regions compared with the other respondents. Symptoms reported included bloating (74%), abdominal discomfort (49%) and flatulence (47%). A total of 23 (47%) srGS individuals reported having had tried a gluten-free or gluten-restricted diet. Abdominal discomfort related to fermentable oligosaccharide, disaccharide, monosaccharide and polyol (FODMAP)-containing food was more often reported in srGS individuals compared with the other respondents (73.5% vs. 21.7%, p FODMAPs are in part responsible for these symptoms. PMID:27834802

  19. Role of FODMAPs in Patients With Irritable Bowel Syndrome.

    Science.gov (United States)

    Mansueto, Pasquale; Seidita, Aurelio; D'Alcamo, Alberto; Carroccio, Antonio

    2015-10-01

    Irritable bowel syndrome (IBS) is a condition characterized by abdominal pain, bloating, flatus, and altered bowel habits. The role of dietary components in inducing IBS symptoms is difficult to explore. To date, foods are not considered a cause but rather symptom-triggering factors. Particular interest has been given to the so-called FODMAPs (fermentable oligo-, di-, and monosaccharides and polyols). We aimed to summarize the evidence from the most common approaches to manage suspected food intolerance in IBS, with a particular interest in the role of FODMAPs and the effects of a low FODMAP diet. We reviewed literature, consulting PubMed and Medline by using the search terms FODMAP(s), fructose, lactose, fructans, galactans, polyols (sorbitol, mannitol, maltitol, xylitol, erythritol, polydextrose, and isomalt), irritable bowel syndrome, and functional gastrointestinal symptoms. FODMAP-restricted diets have been used for a long time to manage patients with IBS. The innovation in the so-called FODMAP concept is that a global restriction should have a more consistent effect than a limited one in preventing abdominal distension. Even though all the potential low FODMAP diets provide good relief of symptoms in many patients, there is just a little relief in others. Several studies highlight the role of low FODMAP diets to improve symptoms in patients with IBS. The evidence on this dietary approach supports the hypothesis that a low FODMAP diet should be the first dietary approach. However, many points remain to be clarified, including the evaluation of possibly significant nutrition concerns.

  20. Efficacy of the low FODMAP diet for treating irritable bowel syndrome: the evidence to date.

    Science.gov (United States)

    Nanayakkara, Wathsala S; Skidmore, Paula Ml; O'Brien, Leigh; Wilkinson, Tim J; Gearry, Richard B

    2016-01-01

    This review summarizes the published clinical studies concerning the management of irritable bowel syndrome (IBS) using restriction of Fermentable Oligosaccharide, Disaccharide, Monosaccharide, and Polyols in the diet (low FODMAP diet). In recent years, the data supporting low FODMAP diet for the management of IBS symptoms have emerged, including several randomized controlled trials, case-control studies, and other observational studies. Unlike most dietary manipulations tried in the past to alleviate gastrointestinal symptoms of IBS, all studies on low FODMAP diet have consistently shown symptomatic benefits in the majority of patients with IBS. However, dietary adherence by the patients and clear dietary intervention led by specialized dietitians appear to be vital for the success of the diet. Up to 86% of patients with IBS find improvement in overall gastrointestinal symptoms as well as individual symptoms such as abdominal pain, bloating, constipation, diarrhea, abdominal distention, and flatulence following the diet. FODMAP restriction reduces the osmotic load and gas production in the distal small bowel and the proximal colon, providing symptomatic relief in patients with IBS. Long-term health effects of a low FODMAP diet are not known; however, stringent FODMAP restriction is not recommended owing to risks of inadequate nutrient intake and potential adverse effects from altered gut microbiota. In conclusion, the evidence to date strongly supports the efficacy of a low FODMAP diet in the treatment of IBS. Further studies are required to understand any potential adverse effects of long-term restriction of FODMAPs.

  1. The low-FODMAP diet for irritable bowel syndrome: Lights and shadows.

    Science.gov (United States)

    Molina-Infante, Javier; Serra, Jordi; Fernandez-Bañares, Fernando; Mearin, Fermín

    2016-02-01

    Irritable bowel syndrome (IBS) affects 10-15% of the western population. Drug therapy for this entity has shown limited efficacy. The low Fermentable Oligo-, Di-, Monosaccharides And Polyols (FODMAP) diet has recently emerged as an effective intervention for reducing gastrointestinal symptoms in IBS. Currently, several mechanistic studies have proven the rational basis of carbohydrate restriction. In addition, high-quality evidence (prospective studies and randomized controlled trials) from a variety of countries supports the high effectiveness of a low-FODMAP diet for IBS symptoms (70%), especially abdominal bloating, pain, and diarrhea. Importantly, this diet seems to be superior to a gluten-free diet for patients with non-celiac gluten sensitivity. The most controversial features of the low FODMAP diet are its short- and long-term limitations (a high level of restriction, the need for monitoring by an expert dietitian, potential nutritional deficiencies, significant gut microbiota reduction, lack of predictors of response), as well as the potential lack of advantage over alternative dietary, pharmacological and psychological interventions for IBS. Although liberalization of carbohydrate intake is recommended in the long-term, the reintroduction process remains to be clarified as, theoretically, global carbohydrate restriction is deemed to be necessary to avoid additive effects.

  2. Irritable bowel syndrome: new insights into symptom mechanisms and advances in treatment [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Robin Spiller

    2016-04-01

    Full Text Available Despite being one of the most common conditions leading to gastroenterological referral, irritable bowel syndrome (IBS is poorly understood. However, recent years have seen major advances. These include new understanding of the role of both inflammation and altered microbiota as well as the impact of dietary intolerances as illuminated by magnetic resonance imaging (MRI, which has thrown new light on IBS. This article will review new data on how excessive bile acid secretion mediates diarrhea and evidence from post infectious IBS which has shown how gut inflammation can alter gut microbiota and function. Studies of patients with inflammatory bowel disease (IBD have also shown that even when inflammation is in remission, the altered enteric nerves and abnormal microbiota can generate IBS-like symptoms. The efficacy of the low FODMAP diet as a treatment for bloating, flatulence, and abdominal discomfort has been demonstrated by randomized controlled trials. MRI studies, which can quantify intestinal volumes, have provided new insights into how FODMAPs cause symptoms. This article will focus on these areas together with recent trials of new agents, which this author believes will alter clinical practice within the foreseeable future.

  3. [Recent insights into the pathogenesis of abdominal symptoms in functional bowel disorders].

    Science.gov (United States)

    Cervio, Elisabetta; Rondanelli, Mariangela; Balestra, Barbara; Dellabianca, Antonio; Agazzi, Alessandro; Giacosa, Attilio; Tonini, Marcello

    2007-02-01

    In the gut, 5-HT acts as a paracrine signalling molecule released by enterochromaffin cells and as a transmitter released by some descending serotonergic interneurons. It has a prominent role in the regulation of motility, vascular tone, secretion and perception both in normal and under certain pathophysiological conditions, such as the carcinoid syndrome and the irritable bowel syndrome (IBS). Serotonin is known to markedly influence bowel function by activating at least five receptor types (5-HT(1,2,3,4,7)). Among all 5-HT receptors, those belonging to the 5-HT3 (a ionotropic receptor) and 5-HT4 (a metabotropic receptor) type are the most extensively studied in gastroenterology, resulting in commercially available (although not worldwide) serotonergic agents for the treatment of IBS and functional dyspepsia. Recently, 5-HT7 receptors have been found to participate in the accommodation process of the circular muscle during the preparatory phase of ileal peristalsis. Since an exaggerated accommodation of the gut wall may contribute to abdominal distension and bloating, 5-HT7 receptor ligands may offer innovative opportunities for the pharmacological treatment of functional bowel disorders.

  4. Object detection via feature synthesis using MDL-based genetic programming.

    Science.gov (United States)

    Lin, Yingqiang; Bhanu, Bir

    2005-06-01

    In this paper, we use genetic programming (GP) to synthesize composite operators and composite features from combinations of primitive operations and primitive features for object detection. The motivation for using GP is to overcome the human experts' limitations of focusing only on conventional combinations of primitive image processing operations in the feature synthesis. GP attempts many unconventional combinations that in some cases yield exceptionally good results. To improve the efficiency of GP and prevent its well-known code bloat problem without imposing severe restriction on the GP search, we design a new fitness function based on minimum description length principle to incorporate both the pixel labeling error and the size of a composite operator into the fitness evaluation process. To further improve the efficiency of GP, smart crossover, smart mutation and a public library ideas are incorporated to identify and keep the effective components of composite operators. Our experiments, which are performed on selected training regions of a training image to reduce the training time, show that compared to normal GP, our GP algorithm finds effective composite operators more quickly and the learned composite operators can be applied to the whole training image and other similar testing images. Also, compared to a traditional region-of-interest extraction algorithm, the composite operators learned by GP are more effective and efficient for object detection.

  5. WASP-South transiting exoplanets: WASP-130b, WASP-131b, WASP-132b, WASP-139b, WASP-140b, WASP-141b & WASP-142b

    CERN Document Server

    Hellier, Coel; Cameron, A Collier; Delrez, L; Gillon, M; Jehin, E; Lendl, M; Maxted, P F L; Neveu-VanMalle, M; Pepe, F; Pollacco, D; Queloz, D; Segransan, D; Smalley, B; Southworth, J; Triaud, A H M J; Udry, S; Wagg, T; West, R G

    2016-01-01

    We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with [Fe/H] = +0.26. Warm Jupiters tend to have smaller radii than hot Jupiters, and WASP-130b is in line with this trend (1.23 Mjup; 0.89 Rjup). WASP-131b is a bloated Saturn-mass planet (0.27 Mjup; 1.22 Rjup). Its large scale height coupled with the V = 10.1 brightness of its host star make the planet a good target for atmospheric characterisation. WASP-132b is among the least irradiated and coolest of WASP planets, being in a 7.1-d orbit around a K4 star. It has a low mass and a modest radius (0.41 Mjup; 0.87 Rjup). The V = 12.4, [Fe/H] = +0.22 star shows a possible rotational modulation at 33 d. WASP-139b is the lowest-mass planet yet found by WASP, at 0.12 Mjup and 0.80 Rjup. It is a "super-Neptune" akin to HATS-7b and HATS-8b. It orbits a V = 12.4, [Fe/H] = +0.20, K0 star. The star appears to be anomalously...

  6. Scientific Opinion on the substantiation of a health claim related to Bimuno® GOS and reducing gastro-intestinal discomfort pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2013-06-01

    Full Text Available Following an application from Clasado Limited, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Malta, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to Bimuno® GOS and reducing gastro-intestinal discomfort. The food constituent, Bimuno® GOS, a mixture of β-galacto-oligosaccharides, which is the subject of the health claim, is sufficiently characterised. The claimed effect proposed by the applicant is “reduce bloating, flatulence and abdominal pain. These effects can be described collectively as abdominal discomfort” and the target population proposed by the applicant is the general adult population. Reducing gastro-intestinal discomfort is a beneficial physiological effect. A health claim on Bimuno® GOS and reducing gastro-intestinal discomfort has already been assessed by the Panel with an unfavourable outcome. The supplementary information submitted by the applicant in this application did not provide evidence that could be used for the scientific substantiation of this claim.

  7. Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management

    Directory of Open Access Journals (Sweden)

    Ayman A Abdo

    2003-01-01

    Full Text Available Microscopic colitis (MC encompasses the two morphologically distinct entities of collagenous colitis (CC and lymphocytic colitis (LC. MC was first described less than 30 years ago but is presently recognized as a relatively common cause of chronic diarrhea in the adult population. Remarkably, up to 10% of adults who have a colonoscopy for the investigation of chronic diarrhea, and have endoscopically normal appearing mucosa, may have MC. Patients with MC generally present with chronic diarrhea, which can be associated with cramping and bloating. Endoscopic and radiological examinations are usually normal. Histological assessment reveals inflammation consisting predominantly of lymphocytic infiltration, and a thickened subepithelial collagen band is diagnostic of CC. Both LC and CC can be associated with autoimmune diseases such as celiac disease, diabetes, arthritis and thyroiditis, yet the mechanisms involved in the pathogenesis remain unclear. Emerging studies suggest that a stepwise approach be taken in the medical management of MC. This approach includes antidiarrheal agents and stopping of any offending agents; budesonide or bismuth subsalicylate; and cholestyramine or 5-acetylsalicylic acid agents. In resistant cases, oral corticosteroids and other immune modulatory therapy have been used.

  8. Physical properties, transmission and emission spectra of the WASP-19 planetary system from multi-colour photometry

    CERN Document Server

    Mancini, L; Chen, G; Tregloan-Reed, J; Fortney, J J; Southworth, J; Tan, T G; Burgdorf, M; Novati, S Calchi; Dominik, M; Fang, X -S; Finet, F; Gerner, T; Hardis, S; Hinse, T C; Jorgensen, U G; Liebig, C; Nikolov, N; Ricci, D; Schaefer, S; Schoenebeck, F; Skottfelt, J; Wertz, O; Alsubai, K A; Bozza, V; Browne, P; Dodds, P; Gu, S -H; Harpsoe, K; Henning, Th; Hundertmark, M; Jessen-Hansen, J; Kains, N; Kerins, E; Kjeldsen, H; Lund, M N; Lundkvist, M; Madhusudhan, N; Mathiasen, M; Penny, M T; Proft, S; Rahvar, S; Sahu, K; Scarpetta, G; Snodgrass, C; Surdej, J

    2013-01-01

    We present new ground-based, multi-colour, broad-band photometric measurements of the physical parameters, transmission and emission spectra of the transiting extrasolar planet WASP-19b. The measurements are based on observations of 8 transits and four occultations using the 1.5m Danish Telescope, 14 transits at the PEST observatory, and 1 transit observed simultaneously through four optical and three near-infrared filters, using the GROND instrument on the ESO 2.2m telescope. We use these new data to measure refined physical parameters for the system. We find the planet to be more bloated and the system to be twice as old as initially thought. We also used published and archived datasets to study the transit timings, which do not depart from a linear ephemeris. We detected an anomaly in the GROND transit light curve which is compatible with a spot on the photosphere of the parent star. The starspot position, size, spot contrast and temperature were established. Using our new and published measurements, we as...

  9. Transanal Irrigation for Refractory Chronic Idiopathic Constipation: Patients Perceive a Safe and Effective Therapy

    Science.gov (United States)

    Minty, Ian; Bain, Iain M.; Cundall, Jeremy; Yiannakou, Yan

    2017-01-01

    Background. Transanal irrigation (TAI) can successfully treat neurogenic bowel dysfunction (NBD), but patient perception of its use in chronic idiopathic constipation (CIC) is unknown. Objective. To evaluate patient perceptions of the efficacy and safety of TAI for CIC and whether there are predictive factors of perceived treatment response. Methods. Prospective data collection of baseline physiology and symptom severity; retrospective evaluation of efficacy and safety perceptions using a snapshot survey. All patients fulfilling the Rome III criteria for functional constipation with chronic idiopathic aetiology were included. The main outcome measure was the duration of patients' usage of TAI. Results. 102 patients reported 21,476 irrigations over 119 patient years, with a mean duration of therapy use of 60.5 weeks [SD 73.2 : SE 7.3]. Overall symptom improvement included general well-being (65%), rectal clearance (63%), bloating (49%), abdominal pain (48%), and bowel frequency (42%). 68 patients (67%) were “moderately better” or “very much better” on a satisfaction question. Reported complications were minor. No correlation was demonstrated between duration of therapy use and baseline measures. Conclusion. A significant proportion of CIC sufferers use TAI as a long-term or bridging therapy and perceive it as safe. This therapy demands a prospective investigation of efficacy and safety. PMID:28115930

  10. Formation of the planet orbiting the millisecond pulsar J1719-1438

    CERN Document Server

    van Haaften, L M; Voss, R; Jonker, P G

    2012-01-01

    In 2011, Bailes et al. reported on the discovery of a detached companion in a 131 minute orbit around PSR J1719-1438, a 173 Hz millisecond pulsar. The combination of the very low mass function and such a short orbital period is unique. The discoverers suggested that the progenitor system could be an ultracompact X-ray binary (UCXB), which is a binary with a sub-hour orbital period in which a (semi-)degenerate donor fills its Roche lobe and transfers mass to a neutron star. The standard gravitational-wave driven UCXB scenario, however, cannot produce a system like PSR J1719-1438 as it would take longer than the age of the Universe to reach an orbital period of 131 min. We investigate two modifications to the standard UCXB evolution that may resolve this discrepancy. The first involves significant heating and bloating of the donor by pulsar irradiation, and in the second modification the system loses orbital angular momentum via a fast stellar wind from the irradiated donor, additional to the losses via the usu...

  11. Histologic effects of different technologies for dissection in endoscopic surgery: Nd:YAG laser, high frequency and water-jet.

    Science.gov (United States)

    Schurr, M O; Wehrmann, M; Kunert, W; Melzer, A; Lirici, M M; Trapp, R; Kanehira, E; Buess, G

    1994-01-01

    Precise cutting combined with reliable coagulation of the margins of the lesion is an important requirement for dissection techniques in endoscopic surgery. These requirements are met by the two most common ancillary energy sources applied for endoscopic dissection today, electrosurgery and "thermal lasers", mostly the Nd:YAG. For the comparison of the histological effects of monopolar and bipolar high frequency with the Nd:YAG laser an experimental in vitro and in vivo study has been performed. In order to evaluate the advantages of non thermal dissection for endoscopic procedures, a water jet cutting system was included in the in vitro study. In parenchymatous tissue the water jet was found to be the least traumatic technique, followed by bipolar high frequency, laser and monopolar high frequency. The water jet was not applicable for intestinal dissection since uncontrolled bloating of the rectal wall with uncontrolled disruption of the tissue layers occurred. A general disadvantage is that secure haemostasis in the line of incision is hard to achieve. In the microscopic comparison of the shape of the incision, the Nd:YAG laser produced the smoothest lesions with well-defined margins. The monopolar technique was more often associated with irregular and sometimes fissured margins. These results were confirmed in the in vivo part of the study (Transanal Endoscopic Microsurgery).

  12. Partial versus complete fundoplication for the correction of pediatric GERD: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Peter Glen

    Full Text Available There is no consensus as to what extent of "wrap" is required in a fundoplication for correction of gastroesophageal reflux disease (GERD.To evaluate if a complete (360 degree or partial fundoplication gives better control of GERD.A systematic search of MEDLINE and Scopus identified interventional and observational studies of fundoplication in children. Screening identified those comparing techniques. The primary outcome was recurrence of GERD following surgery. Dysphagia and complications were secondary outcomes of interest. Meta-analysis was performed when appropriate. Study quality was assessed using the Cochrane Risk of Bias Tool.2289 abstracts were screened, yielding 2 randomized controlled trials (RCTs and 12 retrospective cohort studies. The RCTs were pooled. There was no difference in surgical success between partial and complete fundoplication, OR 1.33 [0.67,2.66]. In the 12 cohort studies, 3 (25% used an objective assessment of the surgery, one of which showed improved outcomes with complete fundoplication. Twenty-five different complications were reported; common were dysphagia and gas-bloat syndrome. Overall study quality was poor.The comparison of partial fundoplication with complete fundoplication warrants further study. The evidence does not demonstrate superiority of one technique. The lack of high quality RCTs and the methodological heterogeneity of observational studies limits a powerful meta-analysis.

  13. What is the evidence for the use of probiotics in functional disorders?

    LENUS (Irish Health Repository)

    Quigley, Eamonn M M

    2012-02-03

    A rationale for the use of probiotics for a number of functional gastrointestinal symptoms and syndromes can be developed, and an experimental basis for their use continues to emerge, but data from well-conducted clinical trials of probiotics in this area remain scarce. Irritable bowel syndrome (IBS) has attracted the most attention; recent revelations regarding the potential pathogenic roles of the enteric flora and immune activation have led to reawakened interest in bacterio-therapy for this common and challenging disorder. Some recent randomized, controlled studies attest to the efficacy of some probiotics in alleviating individual IBS symptoms, and selected strains have a more global impact. Evidence for long-term efficacy is also beginning to emerge, though more studies are needed in this regard. In other functional syndromes, data are far from adequate to make recommendations, but there is evidence for efficacy of probiotics in treating individual symptoms such as diarrhea, constipation, and bloating. The interpretation of much of the literature in this area is complicated by lack of quality control, use of many different species and strains, and, above all, significant deficiencies in trial methodology.

  14. The therapeutic potential of truffle fungi: a patent survey

    Directory of Open Access Journals (Sweden)

    Małgorzata Gajos

    2014-12-01

    Full Text Available The purpose of this article is to research and retrieve patent information regarding the therapeutic use of truffles. Truffles have a unique value as a foodstuff and impact positively on human health and well-being. They are applied in such industries as the pharmaceutical industry and the cosmetic industry. Patent documentation available in the Espacenet network and the Patentscope service were analyzed by key word and patent specifications were examined to describe state of the art and to identify scientific research trends in therapeutic applications of truffles. Medicinal properties of truffles such as the anticancer or cardiovascular effect, a reduction in blood lipids, immunological resistance and increased energy were identified. Other therapeutic benefits include sedative action, prevention of hormonal imbalances in women, pre-menopause symptom relief, senile urethritis and prostate disorders, sleep disorders and increased absorption of calcium from milk. Truffles can also be used to alleviate symptoms of milk intolerance such as diarrhoea or bloating, to ease rheumatic pains and to treat and prevent further development or recurrence of senile cataract.

  15. Association of Medical Directors of Information Systems consensus on inpatient electronic health record documentation.

    Science.gov (United States)

    Shoolin, J; Ozeran, L; Hamann, C; Bria, W

    2013-01-01

    In 2013, electronic documentation of clinical care stands at a crossroads. The benefits of creating digital notes are at risk of being overwhelmed by the inclusion of easily importable detail. Providers are the primary authors of encounters with patients. We must document clearly our understanding of patients and our communication with them and our colleagues. We want to document efficiently to meet without exceeding documentation guidelines. We copy and paste documentation, because it not only simplifies the documentation process generally, but also supports meeting coding and regulatory requirements specifically. Since the primary goal of our profession is to spend as much time as possible listening to, understanding and helping patients, clinicians need information technology to make electronic documentation easier, not harder. At the same time, there should be reasonable restrictions on the use of copy and paste to limit the growing challenge of 'note bloat'. We must find the right balance between ease of use and thoughtless documentation. The guiding principles in this document may be used to launch an interdisciplinary dialogue that promotes useful and necessary documentation that best facilitates efficient information capture and effective display.

  16. Intestinal Obstruction in a 3-Year-Old Girl by Ascaris lumbricoides Infestation: Case Report and Review of the Literature.

    Science.gov (United States)

    Andrade, Angel Medina; Perez, Yeudiel; Lopez, Cecilia; Collazos, Stephanie Serrano; Andrade, Alejandro Medina; Ramirez, Grecia Ortiz; Andrade, Laura Medina

    2015-04-01

    Ascaris lumbricoides infection affects approximately 1.5 billion people globally. Children with environmental and socio-economic risk factors are more susceptible to infestation, with serious complications such as intestinal obstruction (IO), volvulus, intussusception, and intestinal necrosis.We present the case of a 3-year-old girl who arrived at emergency department with abdominal pain and diarrhea for the last 3 days. The previous day she took an unspecified anthelmintic. Symptoms worsened with vomiting and diarrhea, with expulsion of roundworms through mouth and anus. Physical examination revealed bloating, absence of bowel sounds, abdominal tenderness, and a palpable mass in right hemi-abdomen. Abdominal radiographs showed air-fluid levels with mild bowel distention and shadows of roundworms. The diagnosis of IO by A lumbricoides. infestation was established and surgical approach scheduled. During exploratory laparotomy an intraluminal bolus of roundworms from jejunum to ascendant colon was evident. An ileum enterotomy was performed and worms were removed. Fluid therapy and antibiotics for 72  hours were administered, with posterior albendazol treatment for 3 days. Patient was uneventfully discharged on the tenth day.Reduction in parasitic load by means of improvements in sanitation, health education, and anthelmintic treatment must be implemented in endemic zones to prevent serious life-threatening complications by A lumbricoides. infestation, because some of them require urgent surgical treatment.

  17. [Empacho: An historical review of popular Chilean childhood disease (1674-2014)].

    Science.gov (United States)

    Campos Navarro, Roberto

    2016-01-01

    "Empacho" (abdominal pain and bloating), "mal de ojo" (evil eye), "los aires" (illnesses said to be caught by catching draughts), "el susto" or "espanto" (fright or panic), are the principal and most well-known popular Latin American illnesses. As regards empacho, the medical, historical and ethnographic information is extensive and detailed, since there documents recording it from the 16th century until recent times (2014), and in the case of Chile since 1674. For this review, 109 source documents from libraries in Chile, including some foreign ones, were consulted. It was found that the illness is known all over the country. It is a digestive system disorder caused by over-eating and the ingestion of products difficult to digest or indigestible, which cause problems in gastrointestinal transit. The most significant clinical data are gastralgia, diarrhoea or constipation, vomiting, fever, and other discomforts. The illness is treated at home, and if necessary, popular specialists are employed, with a visit to a qualified doctor being exceptional. There are many complex and combined treatments, which go from herbal products to ritual elements, not forgetting the so-called "quebradura del empacho". This review summary of empacho in Chile should enable the paediatrician to enter the world of popular knowledge and practices with the aim of improving the care of child patients and their families. It should also lead to the serious and systematic study of this nosological condition that will continue to exist in the future.

  18. Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Lins Ponte

    2016-02-01

    Full Text Available OBJECTIVE: This work aimed to evaluate and correlate symptoms, biochemical blood test results and single nucleotide polymorphisms for lactose intolerance diagnosis. METHOD: A cross-sectional study was conducted in Fortaleza, Ceará, Brazil, with a total of 119 patients, 54 of whom were lactose intolerant. Clinical evaluation and biochemical blood tests were conducted after lactose ingestion and blood samples were collected for genotyping evaluation. In particular, the single nucleotide polymorphisms C>T-13910 and G>A-22018 were analyzed by restriction fragment length polymorphism/polymerase chain reaction and validated by DNA sequencing. RESULTS: Lactose-intolerant patients presented with more symptoms of flatulence (81.4%, bloating (68.5%, borborygmus (59.3% and diarrhea (46.3% compared with non-lactose-intolerant patients (pT-13910 and G>A-22018 with lactose tolerance in this population and suggest clinical management for patients with lactose intolerance that considers single nucleotide polymorphism detection and a change in the biochemical blood test cutoff from <25 mg/dL to <15 mg/dL.

  19. Lactose malabsorption and intolerance: pathogenesis, diagnosis and treatment.

    Science.gov (United States)

    Misselwitz, Benjamin; Pohl, Daniel; Frühauf, Heiko; Fried, Michael; Vavricka, Stephan R; Fox, Mark

    2013-06-01

    Lactose malabsorption is a common condition caused by reduced expression or activity of lactase in the small intestine. In such patients, lactose intolerance is characterized by abdominal symptoms (e.g. nausea, bloating, and pain) after ingestion of dairy products. The genetic basis of lactose malabsorption is established and several tests for this condition are available, including genetic, endoscopic, and H2-breath tests. In contrast, lactose intolerance is less well understood. Recent studies show that the risk of symptoms after lactose ingestion depends on the dose of lactose, lactase expression, intestinal flora, and sensitivity of the gastrointestinal tract. Lactose intolerance has recently been defined as symptoms developing after ingestion of lactose which do not develop after placebo challenge in a person with lactose maldigestion. Such blinded testing might be especially important in those with functional gastrointestinal diseases in whom self-reported lactose intolerance is common. However, placebo-controlled testing is not part of current clinical practice. Updated protocols and high-quality outcome studies are needed. Treatment options of lactose intolerance include lactose-reduced diet and enzyme replacement. Documenting the response to multiple doses can guide rational dietary management; however, the clinical utility of this strategy has not been tested. This review summarizes the genetic basis, diagnosis, and treatment of lactose malabsorption and intolerance.

  20. New strategies for diagnosis and management of celiac disease.

    Science.gov (United States)

    Westerberg, Dyanne P; Gill, James M; Dave, Bhavin; DiPrinzio, Marie J; Quisel, Anna; Foy, Andrew

    2006-03-01

    Celiac disease is a gastrointestinal disorder characterized by inflammation, leading to injury to the mucosal lining of the small intestine. The inflammation occurs when gliadin, a protein found in such gluten-containing foods as wheat, rye, and barley, is ingested by genetically susceptible individuals. The mucosal damage and subsequent malabsorption of nutrients leads to various complications. Researchers estimate that more than 2 million people in the United States have celiac disease-a prevalence that is greater than was previously believed. Approximately 60,000 Americans are diagnosed annually with celiac disease. Until recently, diagnosis has been complicated by the fact that the indicators of celiac disease are nonspecific. However, because of the development of new, easy-to-administer serology tests, diagnosis has become much less complicated. After conducting a review of the literature, the authors recommend a serologic testing sequence for diagnosis of celiac disease and urge that adults and children with an assortment of symptoms be tested for this disease. Common signs and symptoms of celiac disease include anemia, arthralgia, fatigue, infertility, neuropathy, and weight loss, in addition to such gastrointestinal symptomatology as abdominal pain, anorexia, bloating, constipation, and diarrhea. The only treatment for patients with celiac disease remains a gluten-free diet.

  1. Characterization of the four new transiting planets KOI-188b, KOI-195b, KOI-192b, and KOI-830b

    CERN Document Server

    Hebrard, G; Montagnier, G; Bruno, G; Deleuil, M; Havel, M; Almenara, J -M; Damiani, C; Barros, S C C; Bonomo, A S; Bouchy, F; Diaz, R F; Moutou, C

    2014-01-01

    The characterization of four new transiting extrasolar planets is presented here. KOI-188b and KOI-195b are bloated hot Saturns, with orbital periods of 3.8 and 3.2 days, and masses of 0.25 and 0.34 M_Jup, respectively. They are located in the low-mass range of known transiting, giant planets. KOI-192b has a similar mass (0.29 M_Jup) but a longer orbital period of 10.3 days. This places it in a domain where only few planets are known. KOI-830b, finally, with a mass of 1.27 M_Jup and a period of 3.5 days, is a typical hot Jupiter. The four planets have radii of 0.98, 1.09, 1.2, and 1.08 R_Jup, respectively. We detected no significant eccentricity in any of the systems, while the accuracy of our data does not rule out possible moderate eccentricities. The four objects were first identified by the Kepler Team as promising candidates from photometry of the Kepler satellite. We establish here their planetary nature thanks to the radial velocity follow-up we secured with the HARPS-N spectrograph at the Telescopio N...

  2. Do stellar winds prevent the formation of supermassive stars by accretion?

    Science.gov (United States)

    Nakauchi, Daisuke; Hosokawa, Takashi; Omukai, Kazuyuki; Saio, Hideyuki; Nomoto, Ken'ichi

    2017-03-01

    Supermassive stars (SMSs; ∼105 M⊙) formed from metal-free gas in the early Universe attract attention as progenitors of supermassive black holes observed at high redshifts. To form SMSs by accretion, central protostars must accrete at as high rates as ∼0.1-1 M⊙ yr-1. Such protostars have very extended structures with bloated envelopes, like supergiant stars, and are called supergiant protostars (SGPSs). Under the assumption of hydrostatic equilibrium, SGPSs have density-inverted layers, where the luminosity becomes locally super-Eddington, near the surface. If the envelope matter is allowed to flow out, however, a stellar wind could be launched and hinder the accretion growth of SGPSs before reaching the supermassive regime. We examine whether radiation-driven winds are launched from SGPSs by constructing steady and spherically symmetric wind solutions. We find that the wind velocity does not reach the escape velocity in any case considered. This is because once the temperature falls below ∼104 K, the opacity plummet drastically owing to the recombination of hydrogen and the acceleration ceases suddenly. This indicates that, in realistic non-steady cases, even if outflows are launched from the surface of SGPSs, they would fall back again. Such a 'wind' does not result in net mass-loss and does not prevent the growth of SGPSs. In conclusion, SGPSs will grow to SMSs and eventually collapse to massive black holes of ∼105 M⊙, as long as the rapid accretion is maintained.

  3. WASP-54b, WASP-56b and WASP-57b: Three new sub-Jupiter mass planets from SuperWASP

    CERN Document Server

    Faedi, F; Barros, S C C; Brown, D; Cameron, A Collier; Doyle, A P; Gillon, M; Chew, Y Gomez Maqueo; Hebrard, G; Lendl, M; Liebig, C; Smalley, B; Triaud, A H M J; West, R G; Wheatley, P J; Alsubai, K A; Anderson, D R; Armstrong, D J; Bento, J; Bochinski, J; Bouchy, F; Busuttil, R; Fossati, L; Fumel, A; Haswell, C A; Hellier, C; Holmes, S; Jehin, E; Kolb, U; McCormac, J; Miller, G R M; Moutou, C; Norton, A J; Parley, N; Queloz, D; Skillen, I; Smith, A M S; Udry, S; Watson, C

    2012-01-01

    We present three newly discovered sub-Jupiter mass planets from the SuperWASP survey: WASP-54b is a heavily bloated planet of mass 0.636$^{+0.025}_{-0.024}$ \\mj and radius 1.653$^{+0.090}_{-0.083}$ \\rj. It orbits a F9 star, evolving off the main sequence, every 3.69 days. Our MCMC fit of the system yields a slightly eccentric orbit ($e=0.067^{+0.033}_{-0.025}$) for WASP-54b. We investigated further the veracity of our detection of the eccentric orbit for WASP-54b, and we find that it could be real. However, given the brightness of WASP-54 V=10.42 magnitudes, we encourage observations of a secondary eclipse to draw robust conclusions on both the orbital eccentricity and the thermal structure of the planet. WASP-56b and WASP-57b have masses of 0.571$^{+0.034}_{-0.035}$ \\mj and $0.672^{+0.049}_{-0.046}$ \\mj, respectively; and radii of $1.092^{+0.035}_{-0.033}$ \\rj for WASP-56b and $0.916^{+0.017}_{-0.014}$ \\rj for WASP-57b. They orbit main sequence stars of spectral type G6 every 4.67 and 2.84 days, respectively...

  4. Celiac disease

    Directory of Open Access Journals (Sweden)

    Holtmeier Wolfgang

    2006-03-01

    Full Text Available Abstract Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen; often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years.

  5. [Irritable bowel syndrome, celiac disease and gluten].

    Science.gov (United States)

    Mearin, Fermín; Montoro, Miguel

    2014-08-04

    For many years irritable bowel syndrome (IBS) and celiac disease (CD) have been considered 2 completely separate entities, with CD being clearly related to a permanent gluten intolerance and IBS having no relation with gluten ingestion. However IBS and CD symptoms may be indistinguishable, especially when diarrhea, bloating or abdominal pain predominate. In the last decade several studies have shown that the separation between CD and IBS is not so clear. Thus, some patients who have been diagnosed of IBS suffer in fact from CD. In addition, it seems that there is a group of patients who, without having CD, suffer gluten intolerance that cause them digestive symptoms similar to those of IBS. Gluten sensitivity is defined as the spectrum of morphological, immunological and functional abnormalities that respond to a gluten-free diet. This concept includes histological, immunological and clinical manifestations in the absence of evident morphological abnormalities. Therefore, it is mandatory to establish in a scientific way in which patients a gluten-free diet will be beneficial as well as when this is not justified.

  6. The opioid effects of gluten exorphins: asymptomatic celiac disease.

    Science.gov (United States)

    Pruimboom, Leo; de Punder, Karin

    2015-11-24

    Gluten-containing cereals are a main food staple present in the daily human diet, including wheat, barley, and rye. Gluten intake is associated with the development of celiac disease (CD) and related disorders such as diabetes mellitus type I, depression, and schizophrenia. However, until now, there is no consent about the possible deleterious effects of gluten intake because of often failing symptoms even in persons with proven CD. Asymptomatic CD (ACD) is present in the majority of affected patients and is characterized by the absence of classical gluten-intolerance signs, such as diarrhea, bloating, and abdominal pain. Nevertheless, these individuals very often develop diseases that can be related with gluten intake. Gluten can be degraded into several morphine-like substances, named gluten exorphins. These compounds have proven opioid effects and could mask the deleterious effects of gluten protein on gastrointestinal lining and function. Here we describe a putative mechanism, explaining how gluten could "mask" its own toxicity by exorphins that are produced through gluten protein digestion.

  7. Influence of inhomogeneous static magnetic field-exposure on patients with erosive gastritis: a randomized, self- and placebo-controlled, double-blind, single centre, pilot study.

    Science.gov (United States)

    Juhász, Márk; Nagy, Viktor L; Székely, Hajnal; Kocsis, Dorottya; Tulassay, Zsolt; László, János F

    2014-09-06

    This pilot study was devoted to the effect of static magnetic field (SMF)-exposure on erosive gastritis. The randomized, self- and placebo-controlled, double-blind, pilot study included 16 patients of the 2nd Department of Internal Medicine, Semmelweis University diagnosed with erosive gastritis. The instrumental analysis followed a qualitative (pre-intervention) assessment of the symptoms by the patient: lower heartburn (in the ventricle), upper heartburn (in the oesophagus), epigastric pain, regurgitation, bloating and dry cough. Medical diagnosis included a double-line upper panendoscopy followed by 30 min local inhomogeneous SMF-exposure intervention at the lower sternal region over the stomach with peak-to-peak magnetic induction of 3 mT and 30 mT m(-1) gradient at the target site. A qualitative (post-intervention) assessment of the same symptoms closed the examination. Sham- or SMF-exposure was used in a double-blind manner. The authors succeeded in justifying the clinically and statistically significant beneficial effect of the SMF- over sham-exposure on the symptoms of erosive gastritis, the average effect of inhibition was 56% by p = 0.001, n = 42 + 96. This pilot study was aimed to encourage gastroenterologists to test local, inhomogeneous SMF-exposure on erosive gastritis patients, so this intervention may become an evidence-based alternative or complementary method in the clinical use especially in cases when conventional therapy options are contraindicated.

  8. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe).

    Science.gov (United States)

    Haniadka, Raghavendra; Saldanha, Elroy; Sunita, Venkatesh; Palatty, Princy L; Fayad, Raja; Baliga, Manjeshwar Shrinath

    2013-06-01

    The rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger is an important kitchen spice and also possess a myriad health benefits. The rhizomes have been used since antiquity in the various traditional systems of medicine to treat arthritis, rheumatism, sprains, muscular aches, pains, sore throats, cramps, hypertension, dementia, fever, infectious diseases, catarrh, nervous diseases, gingivitis, toothache, asthma, stroke and diabetes. Ginger is also used as home remedy and is of immense value in treating various gastric ailments like constipation, dyspepsia, belching, bloating, gastritis, epigastric discomfort, gastric ulcerations, indigestion, nausea and vomiting and scientific studies have validated the ethnomedicinal uses. Ginger is also shown to be effective in preventing gastric ulcers induced by nonsteroidal anti-inflammatory drugs [NSAIDs like indomethacin, aspirin], reserpine, ethanol, stress (hypothermic and swimming), acetic acid and Helicobacter pylori-induced gastric ulcerations in laboratory animals. Various preclinical and clinical studies have also shown ginger to possess anti-emetic effects against different emetogenic stimuli. However, conflicting reports especially in the prevention of chemotherapy-induced nausea and vomiting and motion sickness prevent us from drawing any firm conclusion on its effectiveness as a broad spectrum anti-emetic. Ginger has been shown to possess free radical scavenging, antioxidant; inhibition of lipid peroxidation and that these properties might have contributed to the observed gastroprotective effects. This review summarizes the various gastroprotective effects of ginger and also emphasizes on aspects that warranty future research to establish its activity and utility as a gastroprotective agent in humans.

  9. Formation of Massive Primordial Stars: Intermittent UV Feedback with Episodic Mass Accretion

    CERN Document Server

    Hosokawa, Takashi; Kuiper, Rolf; Yorke, Harold W; Omukai, Kazuyuki; Yoshida, Naoki

    2015-01-01

    We present coupled stellar evolution (SE) and 3D radiation-hydrodynamic (RHD) simulations of the evolution of primordial protostars, their immediate environment, and the dynamic accretion history under the influence of stellar ionizing and dissociating UV feedback. Our coupled SE-RHD calculations result in a wide diversity of final stellar masses covering $10~M_\\odot \\lesssim M_* \\lesssim 10^3~M_\\odot$. The formation of very massive ($\\gtrsim 250~M_\\odot$) stars is possible under weak UV feedback, whereas ordinary massive (a few $\\times 10~M_\\odot$) stars form when UV feedback can efficiently halt the accretion. Weak UV feedback occurs in cases of variable accretion, in particular when repeated short accretion bursts temporarily exceed $0.01~M_\\odot~{\\rm yr}^{-1}$, causing the protostar to inflate. In the bloated state, the protostar has low surface temperature and UV feedback is suppressed until the star eventually contracts, on a thermal adjustment timescale, to create an HII region. If the delay time betwe...

  10. Chili Peppers, Curcumins, and Prebiotics in Gastrointestinal Health and Disease.

    Science.gov (United States)

    Patcharatrakul, Tanisa; Gonlachanvit, Sutep

    2016-04-01

    There is growing evidence for the role of several natural products as either useful agents or adjuncts in the management of functional GI disorders (FGIDs). In this review, we examine the medical evidence for three such compounds: chili, a culinary spice; curcumin, another spice and active derivative of a root bark; and prebiotics, which are nondigestible food products. Chili may affect the pathogenesis of abdominal pain especially in functional dyspepsia and cause other symptoms. It may have a therapeutic role in FGIDs through desensitization of transient receptor potential vanilloid-1 receptor. Curcumin, the active ingredient of turmeric rhizome, has been shown in several preclinical studies and uncontrolled clinical trials as having effects on gut inflammation, gut permeability and the brain-gut axis, especially in FGIDs. Prebiotics, the non-digestible food ingredients in dietary fiber, may serve as nutrients and selectively stimulate the growth and/or activity of certain colonic bacteria. The net effect of this change on colonic microbiota may lead to the production of acidic metabolites and other compounds that help to reduce the production of toxins and suppress the growth of harmful or disease-causing enteric pathogens. Although some clinical benefit in IBS has been shown, high dose intake of prebiotics may cause more bloating from bacterial fermentation.

  11. Management of the clinical issue of constipation with abdominal complaints in adults: a national survey of Primary Care physicians and gastroenterologists

    Directory of Open Access Journals (Sweden)

    Enrique Rey

    Full Text Available Irritable bowel syndrome and functional constipation represent a relevant and common health issue. However, real-world clinical practice includes patients with constipation who may or may not have other abdominal complaints (pain, bloating, abdominal discomfort with variable frequency. The goal of the present study was to obtain information on the workload entailed by patients with constipation and associated abdominal complaints, predominant clinical behaviors, education needs, and potential daily practice aids both in Primary Care and gastroenterology settings. The clinical behavior of doctors is generally similar at both levels, despite differences in healthcare approach: use of empiric therapies and clinically guided diagnostic tests, with some differences in colonoscopy use (not always directly accessible from Primary Care. Regarding perceptions, general support and osmotic laxatives are most valued by PC doctors, whereas osmotic laxatives, combined laxatives, and linaclotide are most valued by GE specialists. Furthermore, over half of respondents considered differentiating both diagnoses as challenging. Finally, considerable education needs are self-acknowledged at both levels, as is a demand for guidelines and protocols to help in managing this issue in clinical practice. A strength of this study is its providing a joint photograph of the medical approach and the perceptions of constipation with abdominal discomfort from a medical standpoint. Weaknesses include self-declaration (no formal validation and a response rate potentially biased by professional motivation.

  12. WASP-42 b and WASP-49 b: two new transiting Saturns

    CERN Document Server

    Lendl, M; Collier-Cameron, A; Doyle, A P; Gillon, M; Hellier, C; Jehin, E; Lister, T A; Maxted, P F L; Pepe, F; Pollacco, D; Queloz, D; Smalley, B; Segransan, D; Smith, A M S; Triaud, A H M J; Udry, S; West, R G; Wheatley, P J

    2012-01-01

    We report the discovery of two new transiting planets from the WASP survey. WASP-42 b is a 0.500 +- 0.035 M_J planet orbiting a K1 star at a separation of 0.0548 +- 0.0017 AU with a period of 4.9816872 +- 0.0000073 days. The radius of WASP-42 is 1.080 +- 0.057 R_J while its equilibrium temperature is T_eq = 995 +- 34 K. We detect some evidence of a small but non-zero eccentricity of e = 0.060 +- 0.013. WASP-49 b is a 0.378 +- 0.027 M_J planet around an old G6 star. It has a period of 2.7817387 +- 5.6 x 10-6 days and a separation of 0.0379 +- 0.0011 AU. This planet is slightly bloated, having a radius of 1.115 +- 0.056 R_J and an equilibrium temperature of T_eq = 1369 +- 42 K. Both planets have been followed up intensively in photometry, in total we have obtained 5 full and one partial transit light curves of WASP-42 and 4 full and one partial light curves of WASP-49 using the Euler-Swiss, TRAPPIST and Faulkes South telescopes.

  13. Three WASP-South Transiting Exoplanets: WASP-74b, WASP-83b, and WASP-89b

    Science.gov (United States)

    Hellier, Coel; Anderson, D. R.; Collier Cameron, A.; Delrez, L.; Gillon, M.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smalley, B.; Smith, A. M. S.; Southworth, J.; Triaud, A. H. M. J.; Turner, O. D.; Udry, S.; West, R. G.

    2015-07-01

    We report the discovery of three new transiting hot Jupiters by WASP-South together with the TRAPPIST photometer and the Euler/CORALIE spectrograph. WASP-74b orbits a star of V = 9.7, making it one of the brighter systems accessible to southern telescopes. It is a 0.95MJup planet with a moderately bloated radius of 1.5 {R}{Jup} in a 2 day orbit around a slightly evolved F9 star. WASP-83b is a Saturn-mass planet at 0.3 {M}{Jup} with a radius of 1.0 {R}{Jup}. It is in a 5 day orbit around a fainter (V = 12.9) G8 star. WASP-89b is a 6 MJup planet in a 3 day orbit with an eccentricity of e = 0.2. It is thus similar to massive, eccentric planets such as XO-3b and HAT-P-2b, except that those planets orbit F stars whereas WASP-89 is a K star. The V = 13.1 host star is magnetically active, showing a rotation period of 20.2 days, while star spots are visible in the transits. There are indications that the planet’s orbit is aligned with the stellar spin. WASP-89 is a good target for an extensive study of transits of star spots.

  14. Three WASP-South transiting exoplanets: WASP-74b, WASP-83b & WASP-89b

    CERN Document Server

    Hellier, Coel; Cameron, A Collier; Delrez, L; Gillon, M; Jehin, E; Lendl, M; Maxted, P F L; Pepe, F; Pollacco, D; Queloz, D; Segransan, D; Smalley, B; Smith, A M S; Southworth, J; Triaud, A H M J; Turner, O D; Udry, S; West, R G

    2014-01-01

    We report the discovery of three new transiting hot Jupiters by WASP-South together with the TRAPPIST photometer and the Euler/CORALIE spectrograph. WASP-74b orbits a star of V = 9.7, making it one of the brighter systems accessible to Southern telescopes. It is a 0.95 M_Jup planet with a moderately bloated radius of 1.5 R_Jup in a 2-d orbit around a slightly evolved F9 star. WASP-83b is a Saturn-mass planet at 0.3 M_Jup with a radius of 1.0 R_Jup. It is in a 5-d orbit around a fainter (V = 12.9) G8 star. WASP-89b is a 6 M_Jup planet in a 3-d orbit with an eccentricity of e = 0.2. It is thus similar to massive, eccentric planets such as XO-3b and HAT-P-2b, except that those planets orbit F stars whereas WASP-89 is a K star. The V = 13.1 host star is magnetically active, showing a rotation period of 20.2 d, while star spots are visible in the transits. There are indications that the planet's orbit is aligned with the stellar spin. WASP-89 is a good target for an extensive study of transits of star spots.

  15. Changes in the ruminal contents of buffaloes suffering from digestive disorders

    Directory of Open Access Journals (Sweden)

    K. A. Philip

    2008-01-01

    Full Text Available The objective of the study was to determine the digestive disorders in 45 of local breed buffaloes and their prevalence in Mosul city. Traumatic reticuloperitonitis was 33.3 %, then frothy bloat (15.6 %, simple indigestion was 13.3 % and left side abomasal displacement (11.1 %, where as the occurrence of ruminal acidosis was lesser than other digestive disorders and was about 6.7 %. Also the secondary causes of digestive disorders was (20 % which included some infectious diseases, administration of some antibiotics like oxytetracycline 20 mg/Kg body weight or sulphonamide or Diacleane for 3 successive days to each drug. The results also showed significant changes in ruminal pH, sedimentation activity test and the time needed for methylin blue stain reduction from normal values.Also the ruminal protozoal activity showed significant differences between samples in different cases, and species of bacteria from morphology and stain characteristics with Gram's stain. The total and differential counts of ruminal protozoa was decreased significantly (P<0.05 in all cases. Ruminal protozoa were classified into 14 types firstly in buffaloes in this study.

  16. Intestinal obstruction due to Vasconcellea seeds: Report of three cases and literature review

    Directory of Open Access Journals (Sweden)

    Montoya-González, Juliana

    2015-07-01

    Full Text Available Vasconcellea spp., is a species of Andean papaya commonly cultivated in rural communities close to Medellín, Colombia. Due to the pleasant and sweet flavor of its fruits, children frequently ingest its seeds accidentally. After ingestion, the seeds are engaged in the colonic lumen and block the exit of stools, causing pain and bloating, and promoting bacterial translocation. Diagnosis is based on clinical history and rectal examination. Treatment depends on the degree of local and systemic involvement and includes disimpaction of rectal contents under general anesthesia and colonic washes with 0.9% saline solution. In severe cases derivative colostomy has been required. In the literature there are no reports of intestinal obstruction due to Vasconcellea seeds, possibly because it has been mistaken for seeds of the genus Carica. In this article, three cases treated at pediatric services in Medellín, Colombia, in 2012 and 2013 are described. We note that this is a rarely suspected disease, leading to late diagnosis and potential catastrophic consequences. It is important to educate people to prevent the ingestion of the seeds.

  17. Facial purpura in an elderly patient after upper gastrointestinal endoscopy

    Institute of Scientific and Technical Information of China (English)

    Ilhami Yüksel; (O)zlem Ekiz; Fuat Ekiz; (O)mer Basar; Oeman Yüksel

    2012-01-01

    To the editor:Upper gastrointestinal endoscopy (UGE) is a safe procedure and it is widely used without any complication in general.Complications are due to endoscopic procedure,invasive applications,local anesthetic medication or the sedative drugs like midazolam.Complications of the procedure are hemorrhage,peroration of the stomach or gut,respiratory arrest,reaction to the sedative drugs used like midazolam or pethidine,aspiration pneumonia,damaging of crowned teeth or dental bridgework,infection, cardiac arrest and finally under very unusual circmstances death.Mild complications are sore throat,numb throat,bloated feeling and feeling sleepy.1,2 Oral rash was reported to be a very rare complication (0.3%) of UGE in pediatric population.2 Some scholars reported a facial purpura after endoscopic procedure,previously3-5 Cutaneous complications after UGE may occur,however this condition is usually ignored by physicians.Herein,we present a case of facial purpura in an elderly patient as a mild complication of UGE.

  18. Prevalence of Celiac Disease and Helicobacter Pylori in Patients Referred to Endoscopy Section of Taleghani Hospital

    Directory of Open Access Journals (Sweden)

    P Mohammadi

    2012-07-01

    Full Text Available Introduction: According to previous studies celiac disease(CD is frequently associated with chronic gastritis. The aim of this study was to assess the prevalence of CD and Helicobacter pylori in patients with dyspepsia. Methods: 325 patients were studied from April 2008 to April 2009 who underwent endoscopic procedures for dyspepsia. Gastric antrum, duodenal biopsies, serology with tissue Transglutaminase Antibodies(tTGA and total IgA were performed for detection of H. pylori and CD. Results: Out of 325 patients 312(96% had a positive H. pylori. Heart burn and bloating were the most prevalent symptoms in this study. Twenty one of 25 patients with positive histology for CD who had gastric biopsies were positive for H. pylori(84%. Duodenal biopsy specimens results have shown normal histology in 213(65.5%, hyperplastic polyps in 1(0.4%, duodenitis in 79(24.3% and abnormality in small bowel (Marsh I-IIIc in 25(10%. In term of the serological analysis, 9 of 26 tTGA positive patients had abnormal histology (Marsh I-IIIc(2.7%. Conclusion: Similar to previous reports, we found a high prevalence of H. pylori infection and celiac disease in dyspeptic patients. Therefore, further studies for screening occult CD in dyspeptic patients is seems necessary.

  19. A case report of thyroid storm induced by acute sepsis

    Institute of Scientific and Technical Information of China (English)

    Chiu-Yin Yeh; Wen-Liang Yu

    2016-01-01

    Thyroid storm is a rare but life-threatening condition, which can be induced by many critical diseases. We reported a 40-year-old woman with thyroid goiter manifesting with acute sepsis-induced hyperthyroidism. She mainly presented with abdominal bloating, diarrhea, lower limbs edema and exertional dyspnea. The lactate was 9.5 mmol/L and procalcitonin was 3.8 ng/mL, suggesting acute sepsis. The thyroid echo showed bilateral thyroid goiter. Relevant data included a thyroid-stimulating hormone level of 0.03 mIU/mL;free tetraiodothyronine, 5.67 ng/dL;thyroid-stimulating hormone receptor antibody, 76.9%(normal range, < 14%); and antimicrosomal antibody titer, 1:102 400 (normal range,<1:100), suggesting toxic goiter with thyroid storm. Piperacillin/tazobactam, methimazole and Lugol's iodine achieved a good outcome. The symptoms of early sepsis and those of thyroid storm could be similar. Therefore, a careful history taking, a thorough physical examination and a high degree of suspicion could make early diagnosis and appropriate treatment.

  20. Urban poor program launched.

    Science.gov (United States)

    1991-01-01

    The government of the Philippines has launched a program to deal with the rapidly growing urban poor population. 60 cities (including Metro Manila) are expected to increase their bloated population by 3.8% over 1990 which would be 27.7 million for 1991. Currently there is an exodus of people from the rural areas and by 2000 half the urban population will be squatters and slum dwellers. Basic services like health and nutrition are not expected to be able to handle this type of volume without a loss in the quality of service. The basic strategy of the new program is to recruit private medical practitioners to fortify the health care delivery and nutrition services. Currently the doctor/urban dweller ration is 1:9000. The program will develop a system to pool the efforts of government and private physicians in servicing the target population. Barangay Escopa has been chosen as the pilot city because it typifies the conditions of a highly populated urban area. The projects has 2 objectives: 1) demonstrate the systematic delivery of health and nutrition services by the private sector through the coordination of the government, 2) reduce mortality and morbidity in the community, especially in the 0-6 age group as well as pregnant women and lactating mothers.

  1. Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

    Institute of Scientific and Technical Information of China (English)

    Giulia; Leonardi; Nicola; de; Bortoli; Massimo; Bellini; Maria; Gloria; Mumolo; Francesco; Costa; Angelo; Ricchiuti; Stefano; Bombardieri; Santino; Marchi

    2010-01-01

    Chronic intestinal pseudo-obstruction (CIP) is an infre-quent complication of an active systemic lupus erythema-tosus (SLE). We illustrate a case of SLE inactive-related CIP. A 51-year old female with inactive SLE (ECLAM score 2) was hospitalized with postprandial fullness, vomiting, abdominal bloating and abdominal pain. She had had no bowel movements for five days. Plain abdominal X-ray revealed multiple fluid levels and dilated small and large bowel loops with air-fluid levels. Intestinal contrast radiology detected dilated loops. CIP was diagnosed. The patient was treated with prokinetics, octreotide, claritromycin, rifaximin, azathioprine and tegaserod without any clinical improvement. Then methylprednisolone (500 mg iv daily) was started. After the first administration, the patient showed peristaltic movements. A bowel movement was reported after the second administration. A plain abdominal X-ray revealed no air-fluid levels. Steroid therapy was slowly reduced with complete resolution of the symptoms. The patient is still in a good clinical condition. SLE-related CIP is generally reported as a complication of an active disease. In our case, CIP was the only clinical demonstration of the SLE.

  2. Ovarian Cancer Stroma: Pathophysiology and the Roles in Cancer Development

    Energy Technology Data Exchange (ETDEWEB)

    Furuya, Mitsuko [Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004 (Japan)

    2012-07-18

    Ovarian cancer represents one of the cancers with the worst prognostic in adult women. More than half of the patients who present with clinical signs such as abdominal bloating and a feeling of fullness already show advanced stages. The majority of ovarian cancers grow as cystic masses, and cancer cells easily spread into the pelvic cavity once the cysts rupture or leak. When the ovarian cancer cells disseminate into the peritoneal cavity, metastatic nests may grow in the cul-de-sac, and in more advanced stages, the peritoneal surfaces of the upper abdomen become the next largest soil for cancer progression. Ascites is also produced frequently in ovarian cancers, which facilitates distant metastasis. Clinicopathologic, epidemiologic and molecular studies on ovarian cancers have improved our understanding and therapeutic approaches, but still further efforts are required to reduce the risks in the patients who are predisposed to this lethal disease and the mortality of the patients in advanced stages. Among various molecules involved in ovarian carcinogenesis, special genes such as TP53, BRCA1 and BRCA2 have been well investigated. These genes are widely accepted as the predisposing factors that trigger malignant transformation of the epithelial cells of the ovary. In addition, adnexal inflammatory conditions such as chronic salpingitis and ovarian endometriosis have been great research interests in the context of carcinogenic background of ovarian cancers. In this review, I discuss the roles of stromal cells and inflammatory factors in the carcinogenesis and progression of ovarian cancers.

  3. [Clinical practice guidelines: Irritable bowel syndrome with constipation and functional constipation in adults: Concept, diagnosis, and healthcare continuity. (Part 1 of 2)].

    Science.gov (United States)

    Mearin, F; Ciriza, C; Mínguez, M; Rey, E; Mascort, J J; Peña, E; Cañones, P; Júdez, J

    2017-01-01

    In this Clinical practice guide, an analysis is made of the diagnosis and treatment of adult patients with constipation and abdominal discomfort, under the spectrum of irritable bowel syndrome and functional constipation. These have an important personal, health and social impact, affecting the quality of life of these patients. In irritable bowel syndrome with a predominance of constipation, this is the predominant change in bowel movements, with recurrent abdominal pain, bloating and frequent abdominal distension. Constipation is characterised by infrequent or difficulty in bowel movements, associated with excessive straining during bowel movement or sensation of incomplete evacuation. There is often no underling cause, with an intestinal functional disorder being considered. They have many clinical and pathophysiological similarities, with a similar response of the constipation to common drugs. The fundamental difference is the presence or absence of pain, but not in a way evaluable way; "all or nothing". The severity depends on the intensity of bowel symptoms and other factors, a combination of gastrointestinal and extra-intestinal symptoms, level of involvement, forms of perception, and behaviour. The Rome criteria diagnose functional bowel disorders. This guide is adapted to the Rome criteria IV (May 2016) and in this first part an analysis is made of the alarm criteria, diagnostic tests, and the criteria for referral between Primary Care and Digestive Disease specialists. In the second part, a review will be made of the therapeutic alternatives available (exercise, diet, drug therapies, neurostimulation of sacral roots, or surgery), making practical recommendations for each one of them.

  4. Pseudoaneurysm of the splenic artery mimicking a solid lesion

    Directory of Open Access Journals (Sweden)

    Raffaele Pezzilli

    2016-08-01

    Full Text Available A 64-year-old man presented to the hospital because of hematemesis; on admission, he had weakness and pale skin, tachycardia and hypotension. Laboratory tests revealed severe anemia (hemoglobin 7.8 g/dL; liver, renal and pancreatic function tests were normal. An upper digestive endoscopy revealed a gastric ulcer of the cardia, treated with metallic clips and adrenalin injection. The patient was treated with fluids and was transfused with three units of red blood cells. In the previous two months, due to the presence of bloating and diarrhea, associated with abdominal distension, a colon-computed tomography (CT revealed a large retroperitoneal hypodense mass, 53x37 mm in size, without contrast enhancement localized between the body and the tail of the pancreas and the stomach, near the splenic artery and without signs of infiltration. To better define the mass, endoscopic ultrasound and biopsy were performed; however histopathology of multiple biopsies was not diagnostic, because of the presence of necrotic tissue and inflammatory cells. Since hematemesis recurred, the patient underwent a second upper digestive endoscopic examination, but no source of bleeding was found. Then a new contrast enhanced CT was performed that showed a size reduction of the mass, the presence of blood in the stomach and a small pseudoaneurysm of the splenic artery. Because of these findings an angiograpghic study was carried out; angiography confirmed a splenic artery pseudoaneurysm that was successfully embolized with metal microcoils.

  5. Lubiprostone--a novel treatment for irritable bowel syndrome with constipation.

    Science.gov (United States)

    Owen, Richard T

    2008-09-01

    Irritable bowel syndrome (IBS) is a chronic, highly prevalent gastrointestinal motility disorder characterized by abdominal discomfort/pain associated with altered bowel habits such as diarrhea or constipation or both. Current therapy for the constipation-predominant form (IBS-C) comprises fiber or osmotic or stimulant laxatives. However, these may exacerbate the condition or cause electrolyte disturbances. Lubiprostone is a novel selective chloride channel-2 activator that increases fluid secretion in the intestinal apical cell membrane, increasing gut motility and frequency of stool passage, and alleviating abdominal discomfort/pain. Lubiprostone has very low systemic bioavailability and cannot be quantitated in blood, but its active metabolite, M3, has been pharmacokinetically profiled. Lubiprostone reaches peak plasma concentrations within approximately 1 h and has a half-life of 0.9-1.4 h. Despite this short half-life, lubiprostone can be administered orally twice daily. Its efficacy in IBS-C has been demonstrated in two phase III studies; spontaneous bowel movement frequency increased and stool consistency improved, whereas straining, bloating and severity of constipation decreased. The beneficial effects continued for up to 4 weeks after cessation of lubiprostone. Lubiprostone was well tolerated in the long-term, with nausea and diarrhea being the commonest adverse events. Further studies are ongoing in opioid-induced bowel dysfunction.

  6. Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report.

    Science.gov (United States)

    Makker, Jasbir; Karki, Niraj; Sapkota, Binita; Niazi, Masooma; Remy, Prospere

    2016-08-25

    BACKGROUND Gastroesophageal cancers, previously considered rare, are rapidly increasing worldwide. We present here a unique case of gastroesophageal carcinoma with metastasis to the rectum. CASE REPORT A 60-year-old female patient presented with constipation, bloating, and weight loss of 4-month duration. She had undergone sleeve gastrectomy 6 years before. Endoscopies performed revealed a friable-looking mucosa in the lower esophagus and a polypoid rectal mass. Histopathological examination from both the esophageal and rectal lesions revealed poorly differentiated adenocarcinoma cells. Immunohistochemistry stain from both specimens was positive for CK7 supporting the gastric site primary with metastasis to the rectum. Further evaluation also revealed metastasis to bone and malignant pleural effusion. Chemotherapy with palliative intent was initiated. CONCLUSIONS Colorectal metastasis is commonly seen from cancers of the breast, stomach, melanoma, kidney, prostate, and ovaries. However, colorectal metastasis from gastroesophageal cancer has never been reported in the medical literature. Diagnosis relies on histopathologic examination and immunohistochemical staining of the tumor. Treatment depends on the tumor stage. Tumors with widespread metastatic disease are candidates for palliative chemotherapy.

  7. A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects.

    Science.gov (United States)

    Costabile, Adele; Kolida, Sofia; Klinder, Annett; Gietl, Eva; Bäuerlein, Michael; Frohberg, Claus; Landschütze, Volker; Gibson, Glenn R

    2010-10-01

    There is growing interest in the use of inulins as substrates for the selective growth of beneficial gut bacteria such as bifidobacteria and lactobacilli because recent studies have established that their prebiotic effect is linked to several health benefits. In the present study, the impact of a very-long-chain inulin (VLCI), derived from globe artichoke (Cynara scolymus), on the human intestinal microbiota compared with maltodextrin was determined. A double-blind, cross-over study was carried out in thirty-two healthy adults who were randomised into two groups and consumed 10 g/d of either VLCI or maltodextrin, for two 3-week study periods, separated by a 3-week washout period. Numbers of faecal bifidobacteria and lactobacilli were significantly higher upon VLCI ingestion compared with the placebo. Additionally, levels of Atopobium group significantly increased, while Bacteroides-Prevotella numbers were significantly reduced. No significant changes in faecal SCFA concentrations were observed. There were no adverse gastrointestinal symptoms apart from a significant increase in mild and moderate bloating upon VLCI ingestion. These observations were also confirmed by in vitro gas production measurements. In conclusion, daily consumption of VLCI extracted from globe artichoke exerted a pronounced prebiotic effect on the human faecal microbiota composition and was well tolerated by all volunteers.

  8. The effect of environment on development and survival of pupae of the necrophagous fly Ophyra albuquerquei Lopes (Diptera, Muscidae

    Directory of Open Access Journals (Sweden)

    Rodrigo Ferreira Krüger

    2011-09-01

    Full Text Available The effect of environment on development and survival of pupae of the necrophagous fly Ophyra albuquerquei Lopes (Diptera, Muscidae. Species of Ophyra Robineau-Desvoidy, 1830 are found in decomposing bodies, usually in fresh, bloated and decay stages. Ophyra albuquerquei Lopes, for example, can be found in animal carcasses. The influence of environmental factors has not been evaluated in puparia of O. albuquerquei. Thus, the focus of this work was motivated by the need for models to predict the development of a necrophagous insect as a function of abiotic factors. Colonies of O. albuquerquei were maintained in the laboratory to obtain pupae. On the tenth day of each month 200 pupae, divided equally into 10 glass jars, were exposed to the environment and checked daily for adult emergence of each sample. We concluded that the high survival rate observed suggested that the diets used for rearing the larvae and maintaining the adults were appropriate. Also, the data adjusted to robust generalized linear models and there were no interruptions of O. albuquerquei pupae development within the limits of temperatures studied in southern Rio Grande do Sul, given the high survival presented.

  9. Premenstrual Symptoms in Dysmenorrheic College Students: Prevalence and Relation to Vitamin D and Parathyroid Hormone Levels

    Directory of Open Access Journals (Sweden)

    Bayan A. Obeidat

    2012-11-01

    Full Text Available Objectives: To determine the prevalence of premenstrual symptoms (PMS due to primary dysmenorrhea among a sample of university female students, and to explore possible association with vitamin D and parathyroid (PTH levels, as well as frequency of consumption of dairy products. Design: A cross-sectional study. Setting: One Jordanian university. Subjects: A total of 177 female students aged between 18 and 24 years who experienced primary dysmenorrhea participated in the study and completed a self administered questionnaire to collect information concerning demographics, menstruation- related information, associated specified premenstrual symptoms, and consumption of dairy products. Plasma 25-hydroxyvitamin vitamin D level and intact parathyroid hormone level were measured. Results: Of the 177 participants 91.5% had two or more symptoms among which fatigue, mood swings, anxiety, abdominal bloating, and depression were the most prevalent symptoms. There was no evident association between presence of symptoms and vitamin D status, PTH level or dairy products consumption. Headaches and social withdrawal were significantly lower in those women who consumed high amounts of dairy products. Conclusion: Premenstrual symptoms are very common in young women with primary dysmenorrhea. PMS has no relation to levels of vitamin D, parathyroid hormone or dairy products consumption. Headache and social withdrawal may be affected by dairy product consumption.

  10. Transoral incisionless fundoplication: current status

    Science.gov (United States)

    Sami Trad, Karim

    2016-01-01

    Purpose of review Transoral incisionless fundoplication (TIF) performed with the EsophyX device (Redmond, Washington, USA) is a totally endoscopic procedure with the objectives to mechanically repair a defective gastroesophageal valve and to reduce small hiatal hernias. The recent publication of randomized controlled trials and long-term follow-up data offers the opportunity to reevaluate this treatment modality and its role in the management of patients with chronic gastroesophageal reflux disease (GERD). Recent findings Randomized controlled trials have confirmed the ability of TIF to eliminate troublesome GERD symptoms, heal esophagitis, and improve distal esophageal acid exposure in appropriately selected patient populations. These studies establish TIF's superiority to conventional medical therapy, especially in clinical scenarios where proton-pump inhibitors fail to provide complete symptom relief across the spectrum of classic and atypical GERD manifestations, including regurgitation and laryngopharyngeal reflux. Long-term data indicate sustained positive outcomes and durability up to 6 years after procedure. These results were achieved with a low rate of serious adverse events and usually without introducing troublesome dysphagia, gas bloat, or flatulence. Summary Based on the most recent data, TIF appears to be a valuable treatment alternative for the management of appropriately selected patients with moderate to severe chronic GERD symptoms. PMID:27023164

  11. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy

    Science.gov (United States)

    Ghoshal, Uday C.; Shukla, Ratnakar; Ghoshal, Ujjala

    2017-01-01

    The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is the realization that gut dysbiosis, including small intestinal bacterial overgrowth (SIBO), causes IBS symptoms. Between 4% and 78% of patients with IBS and 1% and 40% of controls have SIBO; such wide variations in prevalence might result from population differences, IBS diagnostic criteria, and, most importantly, methods to diagnose SIBO. Although quantitative jejunal aspirate culture is considered the gold standard for the diagnosis of SIBO, noninvasive hydrogen breath tests have been popular. Although the glucose hydrogen breath test is highly specific, its sensitivity is low; in contrast, the early-peak criteria in the lactulose hydrogen breath test are highly nonspecific. Female gender, older age, diarrhea-predominant IBS, bloating and flatulence, proton pump inhibitor and narcotic intake, and low hemoglobin are associated with SIBO among IBS patients. Several therapeutic trials targeting gut microbes using antibiotics and probiotics have further demonstrated that not all symptoms in patients with IBS originate in the brain but rather in the gut, providing support for the micro-organic basis of IBS. A recent proof-of-concept study showing the high frequency of symptom improvement in patients with IBS with SIBO further supports this hypothesis. PMID:28274108

  12. A case report of thyroid storm induced by acute sepsis

    Directory of Open Access Journals (Sweden)

    Chiu-Yin Yeh

    2016-03-01

    Full Text Available Thyroid storm is a rare but life-threatening condition, which can be induced by many critical diseases. We reported a 40-year-old woman with thyroid goiter manifesting with acute sepsis-induced hyperthyroidism. She mainly presented with abdominal bloating, diarrhea, lower limbs edema and exertional dyspnea. The lactate was 9.5 mmol/L and procalcitonin was 3.8 ng/mL, suggesting acute sepsis. The thyroid echo showed bilateral thyroid goiter. Relevant data included a thyroid-stimulating hormone level of 0.03 μIU/mL; free tetraiodothyronine, 5.67 ng/dL; thyroid-stimulating hormone receptor antibody, 76.9% (normal range, < 14%; and antimicrosomal antibody titer, 1:102400 (normal range, < 1:100, suggesting toxic goiter with thyroid storm. Piperacillin/tazobactam, methimazole and Lugol's iodine achieved a good outcome. The symptoms of early sepsis and those of thyroid storm could be similar. Therefore, a careful history taking, a thorough physical examination and a high degree of suspicion could make early diagnosis and appropriate treatment.

  13. Short term (14 days) consumption of insoluble wheat bran fibre-containing breakfast cereals improves subjective digestive feelings, general wellbeing and bowel function in a dose dependent manner.

    Science.gov (United States)

    Lawton, Clare L; Walton, Jenny; Hoyland, Alexa; Howarth, Elaine; Allan, Peter; Chesters, David; Dye, Louise

    2013-04-22

    This study investigated whether increasing insoluble (predominantly wheat bran) fibre over 14 days improves subjective digestive feelings, general wellbeing and bowel function. A single centre, multi-site, open, within subjects design with a 14 day non-intervention (baseline) monitoring period followed by a 14 day fibre consumption (intervention) period was performed. 153 low fibre consumers (AOAC 985.29) completed a daily symptom diary for 14 days after which they consumed one bowl of ready-to-eat breakfast cereal containing at least 5.4 g fibre (3.5 g from wheat bran) for 14 days and completed a daily symptom diary. Significant improvements were demonstrated in subjective perception of bowel function (e.g., ease of defecation) and digestive feelings (bloating, constipation, feeling sluggish and digestive discomfort). Significant improvements were also found in subjective perception of general wellbeing (feeling less fat, more mentally alert, slim, happy and energetic whilst experiencing less stress, mental and physical tiredness, difficulty concentrating and fewer headaches). In general, improvements in study outcomes increased with increasing cereal/fibre consumption. However, consuming an additional minimum 5.4 g of fibre (3.5 g wheat bran) per day was shown to deliver measurable and significant benefits for digestive health, comfort and wellbeing. Encouraging consumption of relatively small amounts of wheat bran could also provide an effective method of increasing overall fibre consumption.

  14. Short Term (14 Days Consumption of Insoluble Wheat Bran Fibre-Containing Breakfast Cereals Improves Subjective Digestive Feelings, General Wellbeing and Bowel Function in a Dose Dependent Manner

    Directory of Open Access Journals (Sweden)

    Louise Dye

    2013-04-01

    Full Text Available This study investigated whether increasing insoluble (predominantly wheat bran fibre over 14 days improves subjective digestive feelings, general wellbeing and bowel function. A single centre, multi-site, open, within subjects design with a 14 day non-intervention (baseline monitoring period followed by a 14 day fibre consumption (intervention period was performed. 153 low fibre consumers (<15 g/day AOAC 985.29 completed a daily symptom diary for 14 days after which they consumed one bowl of ready-to-eat breakfast cereal containing at least 5.4 g fibre (3.5 g from wheat bran for 14 days and completed a daily symptom diary. Significant improvements were demonstrated in subjective perception of bowel function (e.g., ease of defecation and digestive feelings (bloating, constipation, feeling sluggish and digestive discomfort. Significant improvements were also found in subjective perception of general wellbeing (feeling less fat, more mentally alert, slim, happy and energetic whilst experiencing less stress, mental and physical tiredness, difficulty concentrating and fewer headaches. In general, improvements in study outcomes increased with increasing cereal/fibre consumption. However, consuming an additional minimum 5.4 g of fibre (3.5 g wheat bran per day was shown to deliver measurable and significant benefits for digestive health, comfort and wellbeing. Encouraging consumption of relatively small amounts of wheat bran could also provide an effective method of increasing overall fibre consumption.

  15. A Study on the Dietary Intake and the Nutritional Status among the Pancreatic Cancer Surgical Patients

    Science.gov (United States)

    Park, Joon Seong; Yoon, Dong Sup; Kim, Woo Jeong; Chung, Hae-yun

    2016-01-01

    The adequate dietary intake is important to maintain the nutritional status of the patients after pancreatic cancer surgery. This prospective study was designed to investigate the dietary intake and the nutritional status of the patients who had pancreatic cancer surgery. Thirty-one patients (15 men, 16 women) were enrolled and measured body weight, body mass index (BMI), nutritional risk index (NRI), and Malnutrition Universal Screening Tool (MUST). Actual oral intake with nutritional impact symptoms recorded on the clinical research foam at every meal and medical information were collected from electronic medical charts. The rates of malnutrition at admission were 45.1% (14/31) and 28.9% (9/31) by NRI and MUST method, respectively, but those were increased to 87% (27/31) and 86.6% (26/31) after operation on discharge. The median values of daily intake of energy, carbohydrates, fat, and protein were 588.1 kcal, 96.0 g, 11.8 g, and 27.0 g, respectively. Most patients (n = 20, 64.5%) experienced two or more symptoms such as anorexia, abdominal bloating and early satiety. There were negative correlations between C-reactive protein (CRP) levels and the intake of total energy, protein, fat, and zinc. The rates of malnutrition were increased sharply after surgery and the dietary intake also influenced the inflammatory indicators. The results suggested that need of considering special therapeutic diets for the patients who received pancreatic surgery. PMID:27812517

  16. Stoneware tile manufacturing using rice straw ash as feldspar replacement; Fabricacion de gres porcelanico empleando ceniza de tamo de arroz en sustitucion del feldespato

    Energy Technology Data Exchange (ETDEWEB)

    Alvaro Guzman, A.; John Torres, L.; Martha Cedeno, V.; Silvio Delvasto, A.; Vicente Amigo, B.; Enrique Sanchez, V.

    2013-07-01

    In this research are presented the results of using rice straw ash (RSA) in low proportions as substitute of feldspar for manufacturing stoneware tiles. Specimens of semidry triaxial mixtures, where feldspar was substituted for different percentages (25 % and 50 %) of RSA, were prepared by uniaxial pressing, followed by drying and sintering. Physical and mechanical properties of sintered bodies were evaluated. Porcelain stoneware tile specimens C0 and CF25 reached bending strength and water absorption values were in accordance with standard ISO 13006 (Annex G, BIa) ( {>=} 35 MPa and {<=} 0.5 %, respectively). However, in porcelain stoneware tile specimens CF50 due to bloating phenomenon was not possible obtain commercial tiles in accordance with standard ISO 13006. By using Scanning Electron Microscopy (SEM) needles of primary and secondary mullite were identified in a vitreous phase; and by using X-Ray Diffraction (XRD) mullite and quartz phases were identified. It was concluded that feldspar can be substituted positively by RSA in stoneware tile pastes. (Author)

  17. Reassessment of functional dyspepsia: A topic review

    Institute of Scientific and Technical Information of China (English)

    Andrew Seng Boon Chua

    2006-01-01

    Dyspepsia itself is not a diagnosis but stands for a constellation of symptoms referable to the upper gastrointestinal tract. It consists of a variable combination of symptoms including abdominal pain or discomfort, postprandial fullness, abdominal bloating,early satiety, nausea, vomiting, heartburn and acid regurgitation. Patients with heartburn and acid regurgitation invariably have gastroesophageal reflux disease and should be distinguished from those with dyspepsia. There is a substantial group of patients who do not have a definite structural or biochemical cause for their symptoms and are considered to be suffering from functional dyspepsia (FD). Gastrointestinal motor abnormalities, altered visceral sensation, dysfunctional central nervous system-enteral nervous system (CNSENS) integration and psychosocial factors have all being identified as important pathophysiological correlates. It can be considered as a biopsychosocial disorder with dysregulation of the brain-gut axis being central in origin of disease. FD can be categorized into different subgroups based on the predominant single symptom identified by the patient. This subgroup classification can assist us in deciding the appropriate symptomatic treatment for the patient.

  18. In Vitro Evaluation of Tc-99m Radiopharmaceuticals for Gastric Emptying Studies

    Directory of Open Access Journals (Sweden)

    Türkan Ertay

    2014-02-01

    Full Text Available Objective: Gastrointestinal motility and functional motility disorders causing either delayed or accelerated gastric emptying (GE may result in similar symptoms including nausea, vomiting, early satiety, fullness, bloating, and abdominal discomfort or pain. Hence, it is important to evaluate patients for both rapid and delayed GE in the same test. The gold standard technique to measure GE is scintigraphy by radiolabeled test meals. The aim of this study was to test alternative Tc-99m agents to label eggs as the solid meal and compare to Tc-99m sulfur colloid (SC for gastric emptying studies. Methods: In search of alternative agents for gastric emptying studies, we mixed and fried eggs with four different particulate compounds (Tc-99m labeled SC, tin colloid, nanocolloid and MAA, as well as with free pertechnetate and Tc-99m DTPA. We then measured the stability of these compounds in simulated gastric juice. Results: Our experiments demonstrated that in addition to Tc-99m sulfur colloid;Tc-99m MAA, Tc-99m nanocolloid and Tc-99m tin colloid also appear to make stable complexes with eggs in acidic environment. Conclusion: Therefore, these agents may be used for gastric emptying studies which could be more practical in routine conditions.

  19. Role of cholecystokinin and central serotonergic receptors in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Andrew Seng Boon Chua; PWN Keeling; TG Dinan

    2006-01-01

    Symptoms of functional dyspepsia are characterized by upper abdominal discomfort or pain, early satiety, postprandial fullness, bloating, nausea and vomiting. It is a chronic disorder, with symptoms more than 3 mo per year, and no evidence of organic diseases. Dysfunctional motility, altered visceral sensation, and psychosocial factors have all been identified as major pathophysiological mechanisms. It is believed that these pathophysiological mechanisms interact to produce the observed symptoms.Dyspepsia has been categorized into three subgroups based on dominant symptoms. Dysmotility-like dyspepsia describes a subgroup of patients whose symptom complex is usually related to a gastric sensorimotor dysfunction. The brain-gut peptide cholecystokinin (CCK)and serotonin (5-HT) share certain physiological effects.Both have been shown to decrease gastric emptying and affect satiety. Furthermore the CCK induced anorexia depended on serotonergic functions probably acting via central pathways. We believe that abnormalities of central serotonergic receptors functioning together with a hyper responsiveness to CCK or their interactions may be responsible for the genesis of symptoms in functional dyspepsia (FD).

  20. Visceral response to acute retrograde gastric electrical stimulation in healthy human

    Institute of Scientific and Technical Information of China (English)

    Shu-Kun Yao; Mei-Yun Ke; Zhi-Feng Wang; Da-Bo Xu; Yan-Li Zhang

    2005-01-01

    AIM: To investigate the visceral response to acute retrograde gastric electrical stimulation (RGES) in healthy humans and to derive optimal parameters for treatment of patients with obesity.METHODS: RGES with a series of effective parameters were performed via a bipolar mucosal electrode implanted along the great curvature 5 cm above pylorus of stomach in 12 healthy human subjects. Symptoms associated with dyspepsia and other discomfort were observed and graded during RGES at different settings, including long pulse and pulse train. Gastric myoelectrical activity at baseline and during different settings of stimulation was recorded by a multi-channel electrogastrography.RESULTS: The gastric slow wave was entrained in all the subjects at the pacing parameter of 9 cpm in frequency, 500 ms in pulse width, and 5 mA in amplitude.The frequently appeared symptoms during stimulation were satiety, bloating, discomfort, pain, sting, and nausea. The total symptom score for each subject significantly increased as the amplitude or pulse width was adjusted to a higher scale in both long pulse and pulse train. There was a wide diversity of visceral responses to RGES among individuals.CONCLUSION: Acute RGES can result in a series of symptoms associated with dyspepsia, which is beneficial to the treatment of obesity. Optimal parameter should be determined according to the individual sensitivity to electrical stimulation.

  1. Possibilities for using plant extracts added to ruminant feed aimed at improving production results

    Directory of Open Access Journals (Sweden)

    Grdović Svetlana

    2010-01-01

    Full Text Available The use of plant extracts with the objective of improving production results and the quality of food articles of animal origin is an area which is acquiring increasing scientific importance. Numerous investigations carried out so far on ruminants and other species of domestic animals have been aimed at examining specific bioactive matter of plants. The results of these investigations have demonstrated a positive influence on the production results. A large number of data indicate that plant extracts added to animal feed contribute to increasing overall productivity. Furthermore, plant extracts as additives in animal feed have a positive effect also on the health condition of the animals. A large number of plants have characteristics which potentially improve consumption, digestibility and conversion of food, and also growth. Examinations have been performed of the effects of different plant extracts on food consumption, wool growth, growth and composition of the trunk, milk production, reproductive parameters, agents for wool shearing, preventing bloat, methane production, as well as the influence of plants on curbing nematode infestations of ruminants. This work presents a review of scientific investigations of different plant species and their effects on the production characteristics of ruminants. .

  2. Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials

    Directory of Open Access Journals (Sweden)

    Luis Collado Yurrita

    2014-08-01

    Full Text Available Background: Constipation is an intestinal dysfunction. Prebiotics, such as inulin, can improve bowel function by positively influencing intestinal biota. Aim: To analyze the scientific evidence for the role of inulin in improving bowel function in patients with chronic constipation. Methods: A meta-analysis of randomized controlled clinical trials was conducted, grounded on a literature search for the period 1995-2013 (descriptors: inulin & constipation on PubMed, ScieLo and Central Trials Register Cochrane databases. A total of 24 articles were found, 5 of them were selected for this meta-analysis, involving 252 subjects (experimental group: n = 144, control group: n = 108. The quality of the studies was assessed using the Jadad scale. Results: We found a significant overall effect of inulin on stool frequency (DEM = 0.69, 95%CI: 0.04, 1.34, stool consistency (Bristol scale (DEM = 1.07, 95% CI: 0.70, 1.45, transit time (DEM = -0.57, 95% CI: -0.99, -0.15 and hardness of stool (RR = 0.42, 95% CI: 0.26, 0.70. Pain and bloating do not improve with inulin intake. Conclusions: inulin intake has a positive effect on bowel function.

  3. THE ENVIRONMENT OF THE STRONGEST GALACTIC METHANOL MASER

    Energy Technology Data Exchange (ETDEWEB)

    Sanna, A.; Menten, K. M.; Carrasco-González, C.; Brunthaler, A. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Reid, M. J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Ellingsen, S. P.; Krishnan, V. [School of Mathematics and Physics, University of Tasmania, Private Bag 37, Hobart, Tasmania 7001 (Australia); Moscadelli, L.; Cesaroni, R., E-mail: asanna@mpifr-bonn.mpg.de [INAF, Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy)

    2015-05-01

    The high-mass star-forming site G009.62+00.20 E hosts the 6.7 GHz methanol maser source with the greatest flux density in the Galaxy which has been flaring periodically over the last 10 yr. We performed high-resolution astrometric measurements of the CH{sub 3}OH, H{sub 2}O, and OH maser emission and 7 mm continuum in the region. The radio continuum emission was resolved in two sources separated by 1300 AU. The CH{sub 3}OH maser cloudlets are distributed along two north–south ridges of emission to the east and west of the strongest radio continuum component. This component likely pinpoints a massive young stellar object which heats up its dusty envelope, providing a constant IR pumping for the Class II CH{sub 3}OH maser transitions. We suggest that the periodic maser activity may be accounted for by an independent, pulsating, IR radiation field provided by a bloated protostar in the vicinity of the brightest masers. We also report the discovery of an elliptical distribution of CH{sub 3}OH maser emission in the region of periodic variability.

  4. Three sub-Jupiter-mass planets: WASP-69b & WASP-84b transit active K dwarfs and WASP-70Ab transits the evolved primary of a G4+K3 binary

    CERN Document Server

    Anderson, D R; Delrez, L; Doyle, A P; Faedi, F; Fumel, A; Gillon, M; Chew, Y Gómez Maqueo; Hellier, C; Jehin, E; Lendl, M; Maxted, P F L; Pepe, F; Pollacco, D; Queloz, D; Ségransan, D; Skillen, I; Smalley, B; Smith, A M S; Southworth, J; Triaud, A H M J; Turner, O D; Udry, S; West, R G

    2013-01-01

    We report the discovery of the transiting exoplanets WASP-69b, WASP-70Ab and WASP-84b, each of which orbits a bright star (V~10). WASP-69b is a bloated Saturn-mass planet (0.26 M$_{\\rm Jup}$, 1.06 R$_{\\rm Jup}$) in a 3.868-d period around an active mid-K dwarf. We estimate a stellar age of 1 Gyr from both gyrochronological and age-activity relations, though an alternative gyrochronological relation suggests an age of 3 Gyr. ROSAT detected X-rays at a distance of 60$\\pm$27 arcsec from WASP-69. If the star is the source then the planet could be undergoing mass-loss at a rate of ~10$^{12}$ g s$^{-1}$. This is 1-2 orders of magnitude higher than the evaporation rate estimated for HD 209458b and HD 189733b, both of which have exhibited anomalously-large Lyman-{\\alpha} absorption during transit. WASP-70Ab is a sub-Jupiter-mass planet (0.59 M$_{\\rm Jup}$, 1.16R$_{\\rm Jup}$) in a 3.713-d orbit around the primary of a spatially-resolved G4+K3 binary, with a separation of 3.3 arcsec ($\\geq$800 AU). We exploit the binar...

  5. Repair of paraesophageal hiatal hernias – Is a fundoplication needed?

    DEFF Research Database (Denmark)

    Müller-Stich, Beat P.; Achtstätter, Verena; Diener, Markus K.;

    2015-01-01

    Background: The need for a fundoplication during the repair of paraesophageal hiatal hernias (PEH) remains unclear. Prevention of gastro-esophageal reflux represents a trade-off against the risk of fundoplication related side effects. The aim of the present trial was to compare laparoscopic mesh...... by central randomization to LMAH-C or LMAH-F. Endpoints were postoperative gastro- esophageal reflux, complications, and quality of life 12 months postoperatively. Registration number: DRKS00004492 (www.germanctr.de). Results: Forty patients (9 male, 31 female) were randomized. Patients were well......-F patients postoperative esophagitis was present (p = 0.026). Values of dysphagia (2.1 ± 1.6 vs. 1.9 ± 1.4; p = 0.737), gas bloating (2.6 ± 1.4 vs. 2.8 ± 1.4; p = 0.782) and quality of life (116.0 ± 16.2 vs. 115.9 ± 15.8; p = 0.992) were similar. Relevant postoperative complications occurred in 4 (10...

  6. Laparoscopic subtotal colectomy for colonic inertia.

    Science.gov (United States)

    Sample, Cliff; Gupta, Rohit; Bamehriz, Fahad; Anvari, Mehran

    2005-01-01

    Colonic inertia is an uncommon condition, usually occurring in women in the third decade of life. Severity of symptoms may lead some patients to a surgical consultation. This is a retrospective review of 14 patients who underwent laparoscopic subtotal colectomy for colonic inertia, performed by a single surgeon from August 1993 to November 2002. The mean age of the patients was 38.5 years (range 26-50 years); 93% of the patients were women. The common presenting symptoms included abdominal pain (93%), bloating (100%), constipation (100%), and nausea (57%). Median duration of symptoms before surgery was 4.5 years (range 1-30 years). Subtotal colectomy was completed laparoscopically in 13 patients. There was one conversion (7%) because of adhesions. Eleven patients (78.6%) had undergone previous abdominal surgery. The mean operating room time was 153 minutes (range 113-210 minutes). The median time to full bowel action was 2 days. One patient developed postoperative small bowel obstruction that required open exploration. Complete follow-up was available for 11 patients at a median follow-up of 18 months (range 2-96 months). Ninety-one percent of the patients reported excellent satisfaction with surgery, and their bowel movement frequency changed from 1.2 (+/-0.2) per week preoperatives to 17.2 (+/-2.9) per week postoperatively (P relief in patients with colonic inertia who do not respond to medical measures.

  7. Exploitation of dietary tannins to improve rumen metabolism and ruminant nutrition.

    Science.gov (United States)

    Patra, Amlan K; Saxena, Jyotisna

    2011-01-15

    Tannins (hydrolysable and condensed tannin) are polyphenolic polymers of relatively high molecular weight with the capacity to form complexes mainly with proteins due to the presence of a large number of phenolic hydroxyl groups. They are widely distributed in nutritionally important forage trees, shrubs and legumes, cereals and grains, which are considered as anti-nutritional compounds due to their adverse effects on intake and animal performance. However, tannins have been recognised to modulate rumen fermentation favourably such as reducing protein degradation in the rumen, prevention of bloat, inhibition of methanogenesis and increasing conjugated linoleic acid concentrations in ruminant-derived foods. The inclusion of tannins in diets has been shown to improve body weight and wool growth, milk yields and reproductive performance. However, the beneficial effects on rumen modulation and animal performance have not been consistently observed. This review discusses the effects of tannins on nitrogen metabolism in the rumen and intestine, and microbial populations (bacteria, protozoa, fungi and archaea), metabolism of tannins, microbial tolerance mechanisms to tannins, inhibition of methanogenesis, ruminal biohydrogenation processes and performance of animals. The discrepancies of responses of tannins among different studies are attributed to the different chemical structures (degree of polymerisation, procyanidins to propdelphinidins, stereochemistry and C-C bonding) and concentrations of tannins, and type of diets. An establishment of structure-activity relationship would be required to explain differences among studies and obtain consistent beneficial tannin effects.

  8. Ectopic expression of a basic helix-loop-helix gene transactivates parallel pathways of proanthocyanidin biosynthesis. structure, expression analysis, and genetic control of leucoanthocyanidin 4-reductase and anthocyanidin reductase genes in Lotus corniculatus.

    Science.gov (United States)

    Paolocci, Francesco; Robbins, Mark P; Madeo, Laura; Arcioni, Sergio; Martens, Stefan; Damiani, Francesco

    2007-01-01

    Proanthocyanidins (PAs) are plant secondary metabolites and are composed primarily of catechin and epicatechin units in higher plant species. Due to the ability of PAs to bind reversibly with plant proteins to improve digestion and reduce bloat, engineering this pathway in leaves is a major goal for forage breeders. Here, we report the cloning and expression analysis of anthocyanidin reductase (ANR) and leucoanthocyanidin 4-reductase (LAR), two genes encoding enzymes committed to epicatechin and catechin biosynthesis, respectively, in Lotus corniculatus. We show the presence of two LAR gene families (LAR1 and LAR2) and that the steady-state levels of ANR and LAR1 genes correlate with the levels of PAs in leaves of wild-type and transgenic plants. Interestingly, ANR and LAR1, but not LAR2, genes produced active proteins following heterologous expression in Escherichia coli and are affected by the same basic helix-loop-helix transcription factor that promotes PA accumulation in cells of palisade and spongy mesophyll. This study provides direct evidence that the same subclass of transcription factors can mediate the expression of the structural genes of both branches of PA biosynthesis.

  9. Ethnoveterinary uses of medicinal plants among the Lambani community in Chitradurga district, Karnataka, India

    Institute of Scientific and Technical Information of China (English)

    Ramachandra Naik M; Vaishnavi Venugopalan; Preethi Kumaravelayutham; YL Krishnamurthy

    2012-01-01

    Objective: To explore and document ethnomedicinal knowledge of various plants used by the Lambani ethnic group in Chitradurga District of Karnataka, Southern India for traditional veterinary purposes. The area is rich in plant wealth; therefore this study has been made to prepare an inventory of indigenous medicinal plants and to bring traditional knowledge on record. Methods: In accordance to standardized WHO questionnaires, one hundred fourteen informants - consisting of healers, practitioners, farmers and village headman - were interviewed regarding the medicinal use of the local flora in various tribal villages of Chitradurga District, Karnataka during February 2010 to October 2010. Results: Ethno botanical uses of 39 plants belonging to 24 families have been documented in the present study for their interesting therapeutic properties for various veterinary ailments such as lack of appetites, bloat, fever, ephemeral fever, diarrhea, cough, foot and mouth disease etc. Of the plants studied, most were trees and leaves contributed mainly to the plant part used for medical purpose. Conclusions:Lambani tribe, who are generally poor and live in remote areas, use ethno veterinary medicine (EVM) for the primary healthcare of their animals. The use of plants reveals their interest in ethnomedicine and further research on these species could lead to the discovery of novel bioactive molecules for efficient management of diseases.

  10. Ascariasis as a cause of recurrent abdominal pain.

    Science.gov (United States)

    Guzman, Gerly Edson; Teves, Pedro Montes; Monge, Eduardo

    2010-04-01

    Ascariasis is the most common helminthic infection in developing countries. It may cause chronic abdominal pain, tenderness and bloating. Our aim is to report a case of acute episodic abdominal pain and pancreatitis associated with ascariasis. We report a 59-year-old female patient who was admitted for acute abdominal pain, having had several previous similar events before one of them was diagnosed as acute idiopathic pancreatitis. On admission, her physical exam was normal. Laboratory results showed hemoglobin 12.2 g/dL, white blood cell count 11 900 cells/mm(3), eosinophils 420 cells/mm(3), serum amylase 84 IU/mL, lipase 22 IU/mL and normal liver function tests. Abdominal ultrasound and a plain abdominal X-ray were also normal. An upper endoscopy showed round white worms in the duodenum and the stomach, some of them with bile in their intestines. The intestinal parasites were diagnosed as Ascaris lumbricoides, and the patient was started on albendazole, with full recovery within a week. We believe that ascariasis should be considered in patients with recurrent abdominal pain and idiopathic pancreatitis.

  11. Management of gastroesophageal reflux disease.

    Science.gov (United States)

    Tutuian, Radu; Castell, Donald O

    2003-11-01

    Gastroesophageal reflux disease (GERD) is a chronic condition requiring long-term treatment. Simple lifestyle modifications are the first methods employed by patients and, because of their low cost and simplicity, should be continued even when more potent therapies are initiated. Potent acid-suppressive therapy is currently the most important and successful medical therapy. Whereas healing of the esophageal mucosa is achieved with a single dose of any proton pump inhibitor (PPI) in more than 80% of cases, symptoms are more difficult to control. Patients with persistent symptoms on therapy should be tested (preferably with combined multichannel intraluminal impedance and pH) for association of symptoms with acid, nonacid, or no GER. Long-term follow-up studies indicate that PPIs are efficacious, tolerable, and safe medication. So far, promotility agents have shown limited efficacy, and their side-effect profile outweighs their benefits. Antireflux surgery in carefully selected patients (ie, young, typical GERD symptoms, abnormal pH study, and good response to PPI) is as effective as PPI therapy and should be offered to these patients as an alternative to medication. Still, patients should be informed about the risks of antireflux surgery (ie, risk of postoperative dysphagia; decreased ability to belch, possibly leading to bloating; increased flatulence). Endoscopic antireflux procedures are recommended only in selected patients and given the relative short experience with these techniques, patients treated with endoscopic procedures should be enrolled in a rigorous follow-up program.

  12. Nissen fundoplication for gastro-oesophageal reflux disease: long-term results.

    Science.gov (United States)

    Luostarinen, M

    1995-01-01

    Since its introduction by Rudolph Nissen in 1956, fundoplication has become the most commonly used antireflux procedure. Following fundoplication the majority (80 to 90%) of the patients become symptomfree or have only mild and occasional reflux symptoms in the long run. With a short and loose fundic wrap postoperative dysphagia is not a clinical problem, providing that preoperative manometry shows adequate peristalsis. Flatus is increased after fundoplication, but rarely to a disturbing extent. Patients who have problems with flatus preoperatively are also prone to have complaints postoperatively. Bloating is decreased rather than increased after fundoplication. At endoscopy as intact seen fundic wrap (the main determinant of the long-term outcome) is observed in 70% to 80% of the cases 10 to 20 years after the operation. Oesophageal 24-hour pH-recording is normal and oesophagitis cured in similar number of patients. In conclusion, Nissen fundoplication gives effective cure of symptoms of gastro-oesophageal reflux disease and reliably corrects reflux oesophagitis. Postoperative adverse effects are rare and well tolerable and do not detract from the success of the operation in correctly selected patients.

  13. SOPHIE velocimetry of Kepler transit candidates XI. Kepler-412 system: probing the properties of a new inflated hot Jupiter

    CERN Document Server

    Deleuil, M; Santerne, A; Barros, S C C; Havel, M; Hébrard, G; Bonomo, A S; Bouchy, F; Bruno, G; Damiani, C; Díaz, R F; Montagnier, G; Moutou, C

    2014-01-01

    We confirm the planetary nature of Kepler-412b, listed as planet candidate KOI-202 in the Kepler catalog, thanks to our radial velocity follow-up program of Kepler-released planet candidates, which is on going with the SOPHIE spectrograph. We performed a complete analysis of the system by combining the Kepler observations from Q1 to Q15, to ground-based spectroscopic observations that allowed us to derive radial velocity measurements, together with the host star parameters and properties. We also analyzed the light curve to derive the star's rotation period and the phase function of the planet, including the secondary eclipse. We found the planet has a mass of 0.939 $\\pm$ 0.085 M$_{Jup}$ and a radius of 1.325 $\\pm$ 0.043 R$_{Jup}$ which makes it a member of the bloated giant subgroup. It orbits its G3 V host star in 1.72 days. The system has an isochronal age of 5.1 Gyr, consistent with its moderate stellar activity as observed in the Kepler light curve and the rotation of the star of 17.2 $\\pm$ 1.6 days. Fro...

  14. The Formation Process of Massive Close Spectroscopic Binaries: The Fission Hypothesis Revisited

    Science.gov (United States)

    Zinnecker, H.; Ostriker, J.

    2013-06-01

    The vast majority of massive Main-Sequence stars (M>20 Mo) seem to be born in close interactive binary systems (Chini et al. 2012, Sana et al. 2012). The very process by which these systems form is still a mystery and has received little attention so far. Because the binary separation is so tight (less than 1AU), break-up of a critically rotating protostar ("fission") remains an interesting possibility. However, standard current star formation theory treats fission as unlikely (cf. Tohline 2002, ARAA). We question this view and investigate minimum energy states of compressible polytropic analogs to the well-known incompressible MacLaurin spheroids. Dynamical non-axisymmetric instability at a critical ratio of rotational to gravitational energy (cf. Ostriker and Bodenheimer 1973) during the shrinkage of an accreting, rapidly rotating, bloated, massive protostar AFTER ACCRETION DECLINES may provide the conditions for break-up into a close binary system. Time dependent hydro-dynamical simulations are required to either confirm or reject this hypothesis.

  15. Barber Pole Sign in CT Angiography, Adult Presentation of Midgut Malrotation: A Case Report

    Science.gov (United States)

    Garcelan-Trigo, Juan Arsenio; Tello-Moreno, Manuel; Rabaza-Espigares, Manuel Jesus; Talavera-Martinez, Ildefonso

    2015-01-01

    Adult midgut volvulus is a challenging diagnosis because of its low incidence and nonspecific symptoms. Diagnostic delay and long-term complaints are frequent in this clinical scenario. We reported a patient referred to our diagnostic imaging unit with intermittent abdominal pain, bloating and episodic vomiting for several years. He underwent barium gastrointestinal transit and abdominal ultrasound, which revealed severe gastric dilatation, food retention and slow transit until a depressed duodenojejunal flexure, with malrotation of the midgut and jejunal loops being located in the right upper quadrant. Computed tomography angiography was performed, showing rotation of the small intestine around the mesentery root, suggestive of midgut malrotation. In addition, an abnormal twisted disposition of superior mesenteric artery with corkscrew appearance was seen, shaping the pole-barber sign which was evident in volume rendering three-dimensional reconstructions. The patient underwent scheduled surgical treatment without any complication and had good outcome after hospital discharge and follow-up. Computed tomography plays an important role in evaluation of adult midgut volvulus. In addition, angiographic reconstructions can help us to assess the anatomic disposition of mesenteric vascular supply. Both of these assessments are useful in preoperative management. PMID:26557278

  16. [Chronic idiopathic intestinal pseudo-obstruction: visceral myopathy. Report of 4 cases].

    Science.gov (United States)

    de Pini, A F; de Dávila, M T; Marín, A; Guastavino, E; Ruiz, J A; De Rosa, S

    1993-01-01

    Chronic intestinal pseudo-obstruction is the term applied to a heterogeneous group of functional motility disorders sharing a common clinical expression: signs and symptoms of bowel obstruction in absence of mechanical occlusion. It is caused by ineffective intestinal propulsion. The chronic form of intestinal pseudo-obstruction may be primary or secondary. Primary pseudo-obstruction or chronic idiopathic pseudo-obstruction (CIIP) defines a group of propulsive disorders having no recognized underlying diseases. This study presents four female patients, aged between 4 months to 7 years, and makes a review of the literature. The symptoms, very similar in three of them, were bilious vomiting, abdominal distention and constipation, alternating with diarrhea and malnutrition. The fourth patient, different from the others in the age of onset and evolution, only had severe constipation and abdominal bloating. The diagnostic was made by full thickness biopsies during laparotomy, getting specimens by mapping, at different heights of intestine and stomach. Samples were studied by optic and electronic microscopy and visceral myopathies were found. None of them had urinary disorders. Medical treatment consisted of total parental nutrition and/or enteral nutrition. Cisapride was not effective in the two patients who received it.

  17. Tolerability of a probiotic in subjects with a history of methicillin-resistant Staphylococcus aureus colonisation.

    Science.gov (United States)

    Warrack, S; Panjikar, P; Duster, M; Safdar, N

    2014-12-01

    Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen of major public health importance. Colonisation precedes infection; thus reducing MRSA carriage may be of benefit for reducing infection. Probiotics represent a novel approach to reducing MRSA carriage. We undertook a pilot feasibility randomised controlled trial of the tolerability and acceptability of probiotics for reducing nasal and intestinal carriage of MRSA. In addition, subjects were screened for vancomycin-resistant enterocococci (VRE). Subjects with a history of MRSA were recruited from a large, academic medical center and randomised to take either a placebo or probiotic (Lactobacillus rhamnosus HN001). Subjects returned to the clinic after four weeks for further testing to determine adherence to the probiotic regimen and colonisation of MRSA. 48 subjects were enrolled and randomised. Nearly 25% were transplant recipients and 30% had diabetes. The probiotic was well tolerated in the study population though minor side effects, such as nausea and bloating, were observed. A majority of the subjects randomised to HN001 had good adherence to the regimen. At the four week time point among subjects randomised to the probiotic, MRSA was detected in 67 and 50% of subjects colonised in the nares and the gastrointestinal tract, respectively. Three subjects who initially tested positive for VRE were negative after four weeks of probiotic exposure. Probiotics were well tolerated in our study population of largely immunocompromised subjects with multiple comorbidities. Adherence to the intervention was good. Probiotics should be studied further for their potential to reduce colonisation by multidrug resistant bacteria.

  18. Normal tissue tolerance to external beam radiation therapy: Small bowel; Dose de tolerance a l'irradiation des tissus sains: intestin grele

    Energy Technology Data Exchange (ETDEWEB)

    Martin, E. [Departement de radiotherapie, centre Georges-Francois-Leclerc, 21 - Dijon (France); Pointreau, Y.; Barillot, I. [Service de radiotherapie, centre regional universitaire de cancerologie Henry-S.-Kaplan, hopital Bretonneau, CHRU de Tours, 37 - Tours (France); Roche-Forestier, S. [Centre Jean-Bernard, 72 - Le Mans (France); Barillot, I. [Universite Francois-Rabelais, centre de cancerologie Henry-S.-Kaplan, CHU de Tours, 37 - Tours (France)

    2010-07-15

    The small bowel is a hollow organ involved in the transit and absorption of food. In relation to its anatomical location, a significant amount of this organ is exposed in whole or in part to ionizing radiation in external radiotherapy during abdominal or pelvic irradiation either for primary cancers or metastasis. The acute functional changes during external beam radiation are mainly leading to diarrhea, abdominal pain and bloating. The main late side effects of irradiation of the small intestine are chronic diarrhea, malabsorption with steatorrhoea, abdominal spasms, intestinal obstruction, bleeding and fistulas. The architecture of the small intestine may be considered as parallel with a significant correlation between the irradiated volume of small bowel and the likelihood of acute toxicity, whatever the dose. The literature analysis recommends to consider the volume of small bowel receiving 15 Gy (threshold of 100 to 200 cm{sup 3}) but also 30 and 50 Gy (thresholds of 35 to 300 cm{sup 3}, depending on the level of dose considered). Modern techniques of conformal radiotherapy with modulated intensity will probably have beneficial impact on small bowel toxicity. (authors)

  19. Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?

    Science.gov (United States)

    Piscaglia, Anna Chiara; Laterza, Lucrezia; Cesario, Valentina; Gerardi, Viviana; Landi, Rosario; Lopetuso, Loris Riccardo; Calò, Giovanni; Fabbretti, Giovanna; Brisigotti, Massimo; Stefanelli, Maria Loredana; Gasbarrini, Antonio

    2016-01-01

    AIM To evaluate the prevalence of nodular lymphoid hyperplasia (NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome (IBS)-type symptoms or suspected inflammatory bowel disease (IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening. Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period. RESULTS One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals (only 3%), while it was significantly more prevalent in symptomatic cases (32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis. CONCLUSION About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients. PMID:28028368

  20. Contributions of upper gut hormones and motility to the energy intake-suppressant effects of intraduodenal nutrients in healthy, lean men - a pooled-data analysis.

    Science.gov (United States)

    Schober, Gudrun; Lange, Kylie; Steinert, Robert E; Hutchison, Amy T; Luscombe-Marsh, Natalie D; Landrock, Maria F; Horowitz, Michael; Seimon, Radhika V; Feinle-Bisset, Christine

    2016-09-01

    We have previously identified pyloric pressures and plasma cholecystokinin (CCK) concentrations as independent determinants of energy intake following administration of intraduodenal lipid and intravenous CCK. We evaluated in healthy men whether these parameters also determine energy intake in response to intraduodenal protein, and whether, across the nutrients, any predominant gastrointestinal (GI) factors exist, or many factors make small contributions. Data from nine published studies, in which antropyloroduodenal pressures, GI hormones, and GI /appetite perceptions were measured during intraduodenal lipid or protein infusions, were pooled. In all studies energy intake was quantified immediately after the infusions. Specific variables for inclusion in a mixed-effects multivariable model for determination of independent predictors of energy intake were chosen following assessment for collinearity, and within-subject correlations between energy intake and these variables were determined using bivariate analyses adjusted for repeated measures. In models based on all studies, or lipid studies, there were significant effects for amplitude of antral pressure waves, premeal glucagon-like peptide-1 (GLP-1) and time-to-peak GLP-1 concentrations, GLP-1 AUC and bloating scores (P energy intake. In the model including the protein studies, only BPP was identified as an independent determinant of energy intake (P energy intake by lipid and protein, their contribution to the latter is much less. Moreover, the effects are likely to reflect small, cumulative contributions from a range of interrelated factors.

  1. Adverse Food Reaction and Functional Gastrointestinal Disorders: Role of the Dietetic Approach.

    Science.gov (United States)

    Pasqui, Francesca; Poli, Carolina; Colecchia, Antonio; Marasco, Giovanni; Festi, Davide

    2015-09-01

    Bloating, abdominal discomfort or pain, disturbed bowel habits are very common symptoms, frequently reported by the patients soon after food ingestion. These symptoms may occur in different clinical conditions, such as functional bowel disorders, food adverse reactions, gluten-related syndromes, which frequently are interrelated. Consequently, in clinical practice, it is necessary to perform a correct diagnosis in order to identify, for the single patient, the most appropriate therapeutic strategy, which may include not only specific drugs, but also, and mainly, life style changes (healthy nutritional behavior and constant physical activity). The aim of this review is to provide to the general physician, according to the available evidence, the most appropriate diagnostic work-ups for recognizing the different clinical scenarios (i.e. food allergy and intolerance, functional bowel diseases, gluten-related syndromes), to identify their clinical interrelationships and to suggest the most appropriate management. In fact, as far as food intolerances are concerned, it is well known that the number of patients who believe that their symptoms are related to food intolerance is increasing and consequently they restrict their diet, possibly causing nutritional deficiencies. Furthermore, there is an increasing use of unconventional diagnostic tests for food intolerance which lack accurate scientific evidence; the application of their results may induce misdiagnosis and unhealthy therapeutic choices. Consequently the recognition of food intolerance has to be performed on the basis of reliable tests within an agreed diagnostic workup.

  2. Experimental induction of abdominal tympany, abomasitis, and abomasal ulceration by intraruminal inoculation of Clostridium perfringens type A in neonatal calves.

    Science.gov (United States)

    Roeder, B L; Chengappa, M M; Nagaraja, T G; Avery, T B; Kennedy, G A

    1988-02-01

    The etiologic role of Clostridum perfringens type A in the acute abdominal syndrome characterized by abomasal and rumen tympany, abomasitis, and abomasal ulceration was investigated in neonatal calves. Eight calves, 4 to 12 days old, were inoculated intraruminally with toxigenic C perfringens type A. Before and after C perfringens inoculation, blood samples were collected from all calves for blood gas and serum biochemical analysis and for determination of serum copper concentration; ruminal fluid was obtained for isolation of C perfringens. Calves were monitored daily for clinical signs of the syndrome and, depending on the severity of clinical signs, they were either euthanatized or redosed within 4 to 7 days. After necropsy, specimens obtained from the abomasum and rumen for macroscopic and microscopic examination and for anaerobic bacteriologic culture were processed in routine manner. Intraruminal inoculation of C perfringens type A into healthy calves induced anorexia, depression, bloat, diarrhea, and in some calves, death. Serum copper concentration was within normal range. Necropsy revealed variable degrees of abomasitis, petechial and ecchymotic hemorrhages, and ulcers (ranging from pinpoint to nearly perforate) in the abomasum. Seven of those calves also had multiple trichobezoars in the rumen. These necropsy findings were not seen in calves (controls) given distilled H2O only. In affected calves, acute abdominal syndrome was unrelated to copper deficiency, and C perfringens type A given intraruminally was able to induce clinical signs similar to those of the naturally acquired disease.

  3. Central serotonergic and noradrenergic receptors in functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    S O'Mahony; TG Dinan; PW Keeling; ASB Chua

    2006-01-01

    Functional dyspepsia is a symptom complex characterised by upper abdominal discomfort or pain, early satiety,motor abnormalities, abdominal bloating and nausea in the absence of organic disease. The central nervous system plays an important role in the conducting and processing of visceral signals. Alterations in brain processing of pain, perception and affective responses may be key factors in the pathogenesis of functional dyspepsia. Central serotonergic and noradrenergic receptor systems are involved in the processing of motor,sensory and secretory activities of the gastrointestinal tract. Visceral hypersensitivity is currently regarded as the mechanism responsible for both motor alterations and abdominal pain in functional dyspepsia. Some studies suggest that there are alterations in central serotonergic and noradrenergic systems which may partially explain some of the symptoms of functional dyspepsia. Alterations in the autonomic nervous system may be implicated in the motor abnormalities and increases in visceral sensitivity in these patients.Noradrenaline is the main neurotransmitter in the sympathetic nervous system and again alterations in the functioning of this system may lead to changes in motor function. Functional dyspepsia causes considerable burden on the patient and society. The pathophysiology of functional dyspepsia is not fully understood but alterations in central processing by the serotonergic and noradrenergic systems may provide plausible explanations for at least some of the symptoms and offer possible treatment targets for the future.

  4. A Preliminary Analysis of Insects of Medico-legal Importance in Curitiba, State of Paraná

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    Mauricio Osvaldo Moura

    1997-03-01

    Full Text Available A survey of the carrion fauna was made at two sites in Curitiba, State of Paraná, with the objective of describing the insects associated with carrion and setting up a preliminary data-base for medico-legal purposes in south Brazil. Vertebrate exclusion experiments were carried out in each season between 1994 and 1995 with a 250 g laboratory-bred rat (Rattus norvegicus. Five stages of decomposition were identified: fresh, bloated, decaying, dry and adipocere-like. Some species showed seasonal and site preference and so could be used to identify the probable place and season where death took place. Sarconesia chlorogaster (Diptera, Calliphoridae was restricted to an open field site and to cooler months. Hemilucilia semidiaphana (Diptera, Calliphoridae and Pattonella resona (Diptera, Sarcophagidae were restricted to the forest site and warmer months. Phaenicia eximia (Diptera, Calliphoridae and Oxyletrum discicolle (Coleoptera, Silphidae were present at both sites throughout the year and could be useful for population level analysis. Dissochaetus murray (Coleoptera, Cholevidae was present throughout the year at the forest site and was associated with the adipocere-like stage. Ants played an important role producing post-mortem injuries to the carcasses. Insects of 32 species are reported as being useful in community level approaches

  5. Anti-Inflammatory Cytokines: Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis

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    Masooma Sultani

    2012-01-01

    Full Text Available “Mucositis” is the clinical term used to describe ulceration and damage of the mucous membranes of the entire gastrointestinal tract (GIT following cytotoxic cancer chemotherapy and radiation therapy common symptoms include abdominal pain, bloating, diarrhoea, vomiting, and constipation resulting in both a significant clinical and financial burden. Chemotherapeutic drugs cause upregulation of stress response genes including NFκB, that in turn upregulate the production of proinflammatory cytokines such as interleukin-1β (IL-1β, Interleukin-6 (IL-6, and tumour necrosis factor-α (TNF-α. These proinflammatory cytokines are responsible for initiating inflammation in response to tissue injury. Anti-inflammatory cytokines and specific cytokine inhibitors are also released to limit the sustained or excessive inflammatory reactions. In the past decade, intensive research has determined the role of proinflammatory cytokines in development of mucositis. However, a large gap remains in the knowledge of the role of anti-inflammatory cytokines in the setting of chemotherapy-induced mucositis. This critical paper will highlight current literature available relating to what is known regarding the development of mucositis, including the molecular mechanisms involved in inducing inflammation particularly with respect to the role of proinflammatory cytokines, as well as provide a detailed discussion of why it is essential to consider extensive research in the role of anti-inflammatory cytokines in chemotherapy-induced mucositis so that effective targeted treatment strategies can be developed.

  6. Strongyloidiasis: prevalence, risk factors, clinical and laboratory features among diarrhea patients in Ibadan Nigeria.

    Science.gov (United States)

    Dada-Adegbola, H O; Oluwatoba, O A; Bakare, R A

    2010-12-01

    Strongyloidiasis is a parasitic infection caused by Strongyloides stercoralis. The infection is usually mild or asymptomatic in normal immunocompetent individuals, but could be very severe or even fatal due to hyper infection in individuals who are immunosuppressed. This study aimed at determining the prevalence, risk factors and features of strongyloidiasis among diarrhea patients in Ibadan. This is a descriptive cross-sectional study of diarrhea patients from a teaching hospital, three major government hospitals and one mission hospital in Ibadan. Self administered questionnaire, clinical assessment and laboratory investigations were used to confirm health status and presence of S. stercoralis. Diagnosis was made by microscopic examination of stool in saline preparation and formol-ether concentration. One thousand and ninety patients, (562 (51.6%) males and 528 (48.4%) females) consisting 380 (34.9%) children and 710 (65.1%) adults who had diarrhea were studied. The prevalence rate for the parasite among diarrhea patients was 3.0%. While the risk factor for infection remains contact with contaminated soil, malnutrition, steroid therapy, HIV/AIDS, lymphomas, tuberculosis, and chronic renal failure. Others are maleness, institutionalism and alcoholism. Predominant clinical presentations are abdominal pain, chronic diarrhea, and bloating and weight loss, Strongyloides stercoralis should be considered in diarrhea patients who are either malnourished or immunosuppressed.

  7. Ultrasound-assisted extraction of phenolic compounds from Laurus nobilis L. and their antioxidant activity.

    Science.gov (United States)

    Muñiz-Márquez, Diana B; Martínez-Ávila, Guillermo C; Wong-Paz, Jorge E; Belmares-Cerda, Ruth; Rodríguez-Herrera, Raúl; Aguilar, Cristóbal N

    2013-09-01

    Bay leaves (BL) (Laurus nobilis L., Family: Laureceae) are traditionally used to treat some symptoms of gastrointestinal problems, such as epigastric bloating, impaired digestion, eructing and flatulence. These biological properties are mainly attributed to its phenolic compounds. In this paper, ultrasound-assisted extraction of phenolic compounds from Laurus nobilis L. (Laureceae) was studied. Effects of several experimental factors, such as sonication time, solid/liquid ratio and concentration of solvent on extraction of phenolic compounds were evaluated through a randomized complete block design with factorial treatment arrangement (3(3)). The best extraction conditions were: 1g plant sample with 12 mL of 35% ethanol, for 40 min, obtaining a yield of phenolic compounds of 17.32±1.52 mg g(-1) of plant. In addition, free radical-scavenging potential of DPPH and lipid oxidation inhibition, by linoleic acid peroxidation of the selected extract was measured in order to evidence their antioxidant properties. Results indicated that high amounts of phenolic compounds can be extracted from L. nobilis by ultrasound-assisted extraction technology.

  8. MtPAR MYB transcription factor acts as an on switch for proanthocyanidin biosynthesis in Medicago truncatula.

    Science.gov (United States)

    Verdier, Jerome; Zhao, Jian; Torres-Jerez, Ivone; Ge, Shujun; Liu, Chenggang; He, Xianzhi; Mysore, Kirankumar S; Dixon, Richard A; Udvardi, Michael K

    2012-01-31

    MtPAR (Medicago truncatula proanthocyanidin regulator) is an MYB family transcription factor that functions as a key regulator of proanthocyanidin (PA) biosynthesis in the model legume Medicago truncatula. MtPAR expression is confined to the seed coat, the site of PA accumulation. Loss-of-function par mutants contained substantially less PA in the seed coat than the wild type, whereas levels of anthocyanin and other specialized metabolites were normal in the mutants. In contrast, massive accumulation of PAs occurred when MtPAR was expressed ectopically in transformed hairy roots of Medicago. Transcriptome analysis of par mutants and MtPAR-expressing hairy roots, coupled with yeast one-hybrid analysis, revealed that MtPAR positively regulates genes encoding enzymes of the flavonoid-PA pathway via a probable activation of WD40-1. Expression of MtPAR in the forage legume alfalfa (Medicago sativa) resulted in detectable levels of PA in shoots, highlighting the potential of this gene for biotechnological strategies to increase PAs in forage legumes for reduction of pasture bloat in ruminant animals.

  9. Pharmacology, toxicology, clinical efficacy, and adverse effects of calcium polycarbophil, an enteral hydrosorptive agent.

    Science.gov (United States)

    Danhof, I E

    1982-01-01

    Calcium polycarbophil is the calcium salt of polyacrylic acid crosslinked with divinyl glycol. It is chemically and physiologically inert. In dilute alkali it possesses marked hydrophilic capacity (60 to 100 times its weight), which is the basis for its therapeutic use. In daily dosages of 4 to 5 g in adults, it appears to be quite safe, is non-toxic, does not interfere with digestion or absorption, and does not cause gastrointestinal irritation. It appears to be effective in the treatment of both constipation and diarrhea due to functional or organic causes. Several days of continuous use are necessary before effectiveness becomes apparent. Clinical studies, of which there are relatively few, range from uncontrolled, unblinded evaluations of an almost anecdotal nature to well controlled, double-blind, crossover studies. Additional carefully controlled studies on dietary influences, exercise, and patient compliance would be helpful. Adverse effects, which are minimal, include epigastric fullness or heaviness, abdominal distention and bloating, and flatulence. As with all bulk-forming agents, calcium polycarbophil should not be used by persons who have stenotic lesions of the gastrointestinal tract.

  10. Gluten sensitivity and neurological manifestations

    Directory of Open Access Journals (Sweden)

    Agostino Berio

    2015-12-01

    Full Text Available The authors report on six cases of gluten-sensitivity, also defined non-celiac gluten sensitivity, characterized by abdominal features (diarrhea, bloating, pain, genetic positivity for predisposition to celiac disease (DQB1* 02 in all cases; DQA1*05 in three; DQA1*02 in two, DQB1*03 in two, negative anti-t-Transglutaminase antibodies, normal mucosa on biopsy in four cases, type 1 of Marsh in one case. The subjects presented frequent central nervous system (CNS symptoms: headache in three patients, somnolence in one, electroencephalogram aspecific alterations in three (in two of them with previous seizures, leptomeningeal cyst in one, intracranial calcification in one, cerebral gliosis in two. After a gluten-free diet, all intestinal and clinical CNS features remitted, but re-appeared after gluten reintroduction. On the basis of the neurological signs, the authors stress the relevance of immune innate system in the pathogenesis of these cases with possible subsequent evolution on immune adaptive system involvement.

  11. [Frequent causes of diarrhea: celiac disease and lactose intolerance].

    Science.gov (United States)

    Jankowiak, Carsten; Ludwig, Diether

    2008-06-15

    Celiac disease and lactose intolerance are both relatively frequent diseases with symptoms occurring after ingestion of certain food components. In celiac disease wheat gluten and related proteins of other cereals induce an inflammatory disease of the small intestine in predisposed individuals, leading to gastrointestinal and extraintestinal symptoms. Moreover, there is an association with many other diseases and besides classic symptoms (diarrhea, weight loss, malabsorption) atypical courses with less or lacking gastrointestinal symptoms exist. The prevalence is about 1 : 100 (Europe, USA) and higher than supposed earlier. Diagnostic criteria include serologic tests (tissue transglutaminase antibody, endomysial antibody) and characteristic small bowel histology (lymphocytic infiltration, villous atrophy). Therapy is a strict and lifelong gluten-free diet. Rarely, refractory disease or lack of compliance are associated with increased risk of malignancy and worse prognosis. Lactose intolerance is attributed to low intestinal lactase levels, due to reduced genetic expression or mucosal injury and consequent intolerance to dairy products. The frequency is varying in different ethnic groups, occurring in 10-15% of Northern European people. Intensity of clinical symptoms (diarrhea, abdominal pain, bloating) depends on the amount of ingested lactose and individual activity of intestinal lactase. The capacity of lactose malabsorption can be measured using the noninvasive lactose breath hydrogen test. The treatment is based on a reduced dietary lactose intake or in case of secondary form treatment of the underlying disease.

  12. Practical toxicologic diagnosis.

    Science.gov (United States)

    Mount, M E; Feldman, B F

    1984-08-01

    Strychnine toxicosis is characterized by inducible tetanic seizures and metaldehyde poisoning by fine fasciculations progressing to generalized tremors and seizures. Intoxication with 1080 causes seizures, random running movements, vomiting, defecation, urination, acidosis and hyperglycemia. Intoxication with rodenticides causing coagulopathy is characterized by hemorrhage into body cavities but not necessarily external hemorrhage. Anticholinesterase insecticides cause salivation, urination and defecation, while chlorinated hydrocarbon insecticides cause CNS disturbances. Ethylene glycol intoxication results in ataxia, depression, coma, vomiting and tachypnea, followed by acute renal failure. Urea poisoning causes bloat and CNS signs in cattle. Monensin intoxication in horses lasts several days and causes stiffness, colic, uneasiness and recumbency. Salt poisoning results in depression, seizures and hypernatremia. Lead poisoning is associated with central and peripheral nervous system signs, as well as increased numbers of nucleated RBC and basophilic stippling of RBC. Arsenic poisoning results in GI pain, diarrhea, weakness and death. Copper toxicosis in sheep is manifested by hemolytic anemia, hemoglobinemia and hemoglobinuria. Plants that may intoxicate domestic animals include sorghum, greasewood, halogeton, water hemlock, Japanese yew, larkspur, lupine, milk-weed, philodendron, oleander, castor bean and precatory bean.

  13. Chronic Urticaria: A Cutaneous Manifestation of Celiac Disease

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    Jessica Haussmann

    2006-01-01

    Full Text Available Celiac disease, or gluten-sensitive enteropathy, is an immune-mediated disease of the small bowel that results in malabsorption. It classically presents with gastrointestinal symptoms including chronic diarrhea, weight loss, abdominal bloating and anorexia. It is becoming more frequently identified in asymptomatic patients with a diagnosis of deficiencies related to malabsorption of iron, folic acid, vitamin B12 and vitamin D. It is increasingly identified as a cause for early or refractory osteoporosis. Occasionally, celiac disease presents with cutaneous manifestations alone. Dermatitis herpetiformis is a well-recognized cutaneous manifestation of celiac disease. Other cutaneous manifestations include alopecia, angular stomatitis and aphthous ulcerations. Described here is a case of a 24-year-old woman who presented with intermittent urticaria and gastrointestinal complaints. She was found to have celiac disease on small-bowel biopsy. Both her gastrointestinal symptoms and urticaria resolved when she was put on a gluten-free diet, suggesting that her urticaria was a cutaneous manifestation of celiac disease.

  14. Veal calves’ clinical/health status in large groups fed with automatic feeding devices

    Directory of Open Access Journals (Sweden)

    Giulio Cozzi

    2010-01-01

    Full Text Available Aim of the current study was to evaluate the clinical/health status of veal calves in 3 farms that adopt large group housing and automatic feeding stations in Italy. Visits were scheduled in three phases of the rearing cycle (early, middle, and end. Results showed a high incidence of coughing, skin infection and bloated rumen particularly in the middle phase while cross-sucking signs were present at the early stage when calves’ nibbling proclivity is still high. Throughout the rearing cycle, the frequency of bursitis increased reaching 53% of calves at the end. The percentage of calves with a poorer body condition than the mid-range of the batch raised gradually as well, likely due to the non-proportioned teat/calves ratio that increases competition for feed and reduces milk intake of the low ranking animals. The remarked growth differences among pen-mates and the mortality rate close to 7% showed by the use of automatic feeding devices for milk delivery seem not compensating the lower labour demand, therefore its sustainability at the present status is doubtful both for the veal calves’ welfare and the farm incomes.

  15. Medium-chain Triglyceride Ketogenic Diet, An Effective Treatment for Drug-resistant Epilepsy and A Comparison with Other Ketogenic Diets

    Directory of Open Access Journals (Sweden)

    Yeou-mei Christiana Liu

    2013-02-01

    Full Text Available The ketogenic diet (KD is one of the most effective therapies for drug-resistant epilepsy. The efficacy of the medium-chain triglyceride KD (MCTKD is as excellent as the classic KD (CKD, which has been documented in several subsequent retrospective, prospective, and randomized studies. MCT oil is more ketogenic than long-chain triglycerides. Therefore, the MCTKD allows more carbohydrate and protein food, which makes the diet more palatable than the CKD. The MCTKD is not based on diet ratios as is the CKD, but uses a percentage of calories from MCT oil to create ketones. There has also been literature which documents the associated gastrointestinal side effects from the MCTKD, such as diarrhea, vomiting, bloating, and cramps. Therefore, the MCTKD has been an underutilized diet therapy for intractable epilepsy among children.The author has used up to >70% MCTKD diet to maximize seizure control with gastrointestinal side effects optimally controlled. As long as health care professionals carefully manage MCTKD, many more patients with epilepsy who are not appropriate for CKD or modified Atkins diet or low glycemic index treatment will benefit from this treatment. A comparison between the MCTKD and other KDs is also discussed.

  16. Do Stellar Winds Prevent the Formation of Supermassive Stars by Accretion?

    CERN Document Server

    Nakauchi, Daisuke; Omukai, Kazuyuki; Saio, Hideyuki; Nomoto, Ken'ichi

    2016-01-01

    Supermassive stars (SMS; ~ 10^5 M_sun) formed from metal-free gas in the early Universe attract attention as progenitors of supermassive black holes observed at high redshifts. To form SMSs by accretion, central protostars must accrete at as high rates as ~ 0.1-1 M_sun/yr. Such protostars have very extended structures with bloated envelopes, like super-giant stars, and are called super-giant protostars (SGPSs). Under the assumption of hydrostatic equilibrium, SGPSs have density inverted layers, where the luminosity becomes locally super-Eddington, near the surface. If the envelope matter is allowed to flow out, however, a stellar wind could be launched and hinder the accretion growth of SGPSs before reaching the supermassive regime. We examine whether radiation-driven winds are launched from SGPSs by constructing steady and spherically symmetric wind solutions. We find that the wind velocity does not reach the escape velocity in any case considered. This is because once the temperature falls below ~ 10^4 K, t...

  17. K2-30 b and K2-34 b: Two inflated hot Jupiters around solar-type stars

    Science.gov (United States)

    Lillo-Box, J.; Demangeon, O.; Santerne, A.; Barros, S. C. C.; Barrado, D.; Hébrard, G.; Osborn, H. P.; Armstrong, D. J.; Almenara, J.-M.; Boisse, I.; Bouchy, F.; Brown, D. J. A.; Courcol, B.; Deleuil, M.; Delgado Mena, E.; Díaz, R. F.; Kirk, J.; Lam, K. W. F.; McCormac, J.; Pollacco, D.; Rajpurohit, A.; Rey, J.; Santos, N. C.; Sousa, S. G.; Tsantaki, M.; Wilson, P. A.

    2016-10-01

    We report the discovery of the two hot Jupiters K2-30 b and K2-34 b. The two planets were detected during campaigns 4 and 5 of the extension of the Kepler mission, K2; they transit their main-sequence stars with periods of ~4.099 and ~2.996 days. Subsequent ground-based radial velocity follow-up with SOPHIE, HARPS-N, and CAFE established the planetary nature of the transiting objects. We analyzed the transit signal, radial velocity, and spectral energy distributions of the two systems to characterize their properties. Both planets (K2-30 b and K2-34 b) are bloated hot Jupiters (1.20 RJup and 1.22 RJup) around relatively bright (V = 13.5 and V = 11.5) slow rotating main-sequence (G8 and F9) stars. Thus, these systems are good candidates for detecting the Rossiter-MacLaughlin effect in order to measure their obliquity and for atmospheric studies. Full Tables 1 and 2 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/594/A50

  18. EPIC210957318b and EPIC212110888b: two inflated hot-Jupiters around Solar-type stars

    CERN Document Server

    Lillo-Box, J; Santerne, A; Barros, S C C; Barrado, D; Hébrard, G; Osborn, H P; Armstrong, D J; Almenara, J -M; Boisse, I; Bouchy, F; Brown, D J A; Courcol, B; Deleuil, M; Mena, E Delgado; Díaz, R F; Kirk, J; Lam, K W F; McCormac, J; Pollacco, D; Rajpurohit, A; Rey, J; Santos, N C; Sousa, S G; Tsantaki, M; Wilson, P A

    2016-01-01

    We report the discovery of the two hot-Jupiters EPIC210957318b and EPIC212110888b (hereafter EPIC-318b and EPIC-888b, respectively). The two planets were detected transiting their main-sequence star with periods $\\sim$ 4.099 and $\\sim$ 2.996 days, in campaigns 4 and 5 of the extension of the Kepler mission, K2. Subsequent ground-based radial velocity follow-up with SOPHIE, HARPS-N and CAFE, established the planetary nature of the transiting objects. We analyzed the transit signal, radial velocity and spectral energy distributions of the two systems to characterize their properties. Both planets (EPIC-318b and EPIC-888b) are bloated hot-Jupiters (1.25 $R_{\\rm Jup}$ and 1.33 $R_{\\rm Jup}$) around relatively bright (V =13.5 and V=11.5), slow rotating main-sequence (G8 and F9) stars. Thus, these systems are good candidates for detecting the Rossiter-MacLaughlin effect to measure their obliquity and for atmospheric studies.

  19. Small Intestinal Bacterial Overgrowth in Patients with Refractory Functional Gastrointestinal Disorders

    Science.gov (United States)

    Shimura, Shino; Ishimura, Norihisa; Mikami, Hironobu; Okimoto, Eiko; Uno, Goichi; Tamagawa, Yuji; Aimi, Masahito; Oshima, Naoki; Sato, Shuichi; Ishihara, Shunji; Kinoshita, Yoshikazu

    2016-01-01

    Background/Aims Small intestinal bacterial overgrowth (SIBO) is considered to be involved in the pathogenesis of functional gastrointestinal disorders (FGID). However, the prevalence and clinical conditions of SIBO in patients with FGID remain to be fully elucidated. Here, we examined the frequency of SIBO in patients with refractory FGID. Methods We prospectively enrolled patients with refractory FGID based on Rome III criteria. A glucose hydrogen breath test (GHBT) was performed using a gas analyzer after an overnight fast, with breath hydrogen concentration measured at baseline and every 15 minutes after administration of glucose for a total of 3 hours. A peak hydrogen value ≥ 10 ppm above the basal value between 60 and 120 minutes after administration of glucose was diagnosed as SIBO. Results A total of 38 FGID patients, including 11 with functional dyspepsia (FD), 10 with irritable bowel syndrome (IBS), and 17 with overlapping with FD and IBS, were enrolled. Of those, 2 (5.3%) were diagnosed with SIBO (one patient diagnosed with FD; the other with overlapping FD and IBS). Their symptoms were clearly improved and breath hydrogen levels decreased to normal following levofloxacin administration for 7 days. Conclusions Two patients initially diagnosed with FD and IBS were also diagnosed with SIBO as assessed by GHBT. Although the frequency of SIBO is low among patients with FGID, it may be important to be aware of SIBO as differential diagnosis when examining patients with refractory gastrointestinal symptoms, especially bloating, as a part of routine clinical care. PMID:26554916

  20. Primary duodenal adenocarcinoma: case report of an infrequent tumor

    Directory of Open Access Journals (Sweden)

    Óscar Moreno-Loaíza

    2013-10-01

    Full Text Available Introduction. Primary duodenal adenocarcinoma is an infrequent tumor both in our environment and in the world. There is no conclusive evidence on its epidemiology, diagnostic criteria, treatment or prognosis. Clinical case. We report a 77 year-old female patient, of mixed racial origin, native of Cusco (Peru who consulted for abdominal pain, weight loss, nausea, postprandial vomiting and bloating of three months course. At the time of examination she had second to third degree protein malnutrition with a BMI of 16.88 kg/m2, signs of moderate to severe chronic anemia and an 8 cm abdominal tumor in the epigastrium and right hypochondrium. The multislice spiral abdominal CT and ultrasonography revealed the presence of a solid tumor in the second portion of the duodenum. The patient was submitted to a gastroenterostomy without tumor resection. Biopsy confirmed tubular adenocarcinoma. Furthermore, no other primary tumors were found in the stomach, pancreas, biliary tree and colon. The patient was stabilized and was treated with 5-fluorouracil, irinotecan and leucovorin. Literature review. The article includes a brief review on the diagnosis, treatment and prognosis of this condition. Discussion. Management is not straightforward. There is little literature on the subject leaving decisions up to the attending physician’s criteria. We believe that all cases of rare diseases should be studied in depth, give rise to a thorough review of literature and, above all, be brought to the attention of the medical community.

  1. CHARACTERISTICS OF BACTERIOCIN BA28 PRODUCED BY Pediococcus acidilactici BA28

    Directory of Open Access Journals (Sweden)

    Kaur Baljinder

    2013-01-01

    Full Text Available Peptic ulcers are produced by an imbalance between gastro-duodenal mucosal defense mechanisms and damaging forces of gastric acid and pepsin, combined with superimposed injury from environmental or immunologic agents. Most common symptoms of peptic ulcer disease are abdominal discomfort, gnawing ache, occurs 2 to 3 hours after meal, other symptoms includes weight loss, poor appetite, bloating, nausea, vomiting etc. Some time duodenal wall perforates; bleeding due to the ulcer breaks blood vessels and obstructs the path of food trying to leave the stomach. Various studies have shown the association of Helicobacter pylori with peptic ulcers. Probiotic lactic acid bacteria are proposed to cure peptic ulcers by reducing colonization of H. pylori with stomach wall and by eradicating already established infection. A bacteriocin producing probiotic strain of P. acidilactici BA28 was evaluated for its antimicrobial activity against a number of Gram-positive and Gram-negative pathogens. Bacteriocin BA28 was partially purificated and characterized following in vitro assays. Preliminary investigations against H. plyori have suggested its effectiveness against peptic ulcer disease and therefore could be exploited to develop novel therapeutics.

  2. IDENTIFICATION OF ASPECTS USING COLOURED PETRINETS AND ASPECT REALIZATION

    Directory of Open Access Journals (Sweden)

    S.SOWMYADEVI

    2013-04-01

    Full Text Available a major impediment to program comprehension, maintenance and resolvability is the existence of crosscutting concerns scattered across different modules tangled with implementations of other concerns. Presence of crosscutting concerns in software systems can lead to bloated and inefficient software systems that are difficult to evolve, hard to analyse, difficult to reuse and costly to maintain. Aspect-oriented programming is a complementary programming technique to the object-oriented programming. It provides tools for managing so called cross-cutting concerns. The concept of aspect orientation with presentation of a method could modulate crosscutting concerns into the single manageable unit called, aspect. This method will solve many problems such as tangling and scattering of code. But the identification and specification of crosscutting concerns and considering it as aspects is not an easy job. The proposed method defines requirements and concerns in the formal form by Petri Nets and named them as requirement nets and concern nets. Concern nets with dependencies which there are between requirement nets, model the final system. The execution of final modelled software system based on Petri Nets and monitoring its transitions, shows crosscutting concerns which are candidate aspects. In this paper, we propose a formal method based on Petri Nets, for the identification of aspect and finding out the most dominant aspect. Then the aspect realization is done by using programming language with some case study.

  3. Characterization and control of Mucor circinelloides spoilage in yogurt.

    Science.gov (United States)

    Snyder, Abigail B; Churey, John J; Worobo, Randy W

    2016-07-02

    Consumer confidence in the food industry is severely affected by large-scale spoilage incidents. However, relatively little research exists on spoilage potential of members of the fungal subphylum Mucormycotina (e.g. Mucor), which includes dimorphic spoilage organisms that can switch between a yeast-like and hyphal phase depending on environmental conditions. The presence of Mucor circinelloides in yogurt may not cause spoilage, but growth and subsequent changes in quality (e.g. container bloating) can cause spoilage if not controlled. The purpose of this study was to evaluate the effects on M. circinelloides of pasteurization regimen, natamycin concentrations, and storage temperature in yogurt production, as measured by fungal proliferation and carbon dioxide production. A strain of M. circinelloides isolated from commercially spoiled yogurt showed greater yogurt-spoilage potential than clinical isolates and other industrial strains. D-values and z-values were determined for the spoilage isolate in milk as an evaluation of the fungus' ability to survive pasteurization. Natamycin was added to yogurt at 0, 5, 10, 15, and 20ppm (μg/ml) to determine its ability to inhibit M. circinelloides over the course of month-long challenge studies at 4°C, 15°C, and 25°C. Survivors were recovered on acidified PDA and carbon dioxide levels were recorded. The D-values at 54°C, 56°C, and 58°C for hyphae/sporangiospores were (in min) 38.31±0.02, 10.17±0.28, and 1.94±0.53, respectively, which yielded a z-value of 3.09°C. The D-values at 51°C, 53°C, and 55°C for yeast-like cells were (in min) 14.25±0.12, 6.87±1.19, and 2.44±0.35, respectively, which yielded a z-value of 0.34°C. These results indicated that M. circinelloides would not survive fluid milk pasteurization if contamination occurred prior to thermal treatment. CO2 production was only observed when M. circinelloides was incubated under low-oxygen conditions, and occurred only at temperatures above 4

  4. Perbedaan Tolerabilitas Meloxicam dengan Natrium Diklofenak terhadap Saluran Cerna pada Pasien Rawat Jalan di PoliklinikPenyakit Saraf Rumah Sakit Angkatan Laut Dr. Mintohardjo Jakarta 2011

    Directory of Open Access Journals (Sweden)

    Lailan Azizah

    2013-06-01

    gastrointestinal side-effects. Inhibition of the cyclooxygenase (COX enzyme is the basis for both the efficacy and toxicity of NSAIDs. The aim of thisstudy was to avaluate the non-steroidal anti-inflammatory drugs were used in neuro polyclinic hospital of Dr. Mintohardjo Jakarta, and to evaluate gastrointestinal tolerability of meloxicam 15 mg compared with diclofenac sodium 100 mg. The methode of this study was cross-sectional observation and cohort prospective on December 2010-March 2011. The data of dyspepsia associated were used non-steroidal anti-inflammatory drugs consist of pain in upper abdomen, nausea, vomiting, upper abdominal bloating and early satiety collected with the porto alegre dyspeptic symptoms questionnaire (PADYQ were assessed at baseline and after 2 and 4weeks of treatment. The non-steroidal anti-inflammatory drugs used in neuro polyclinic hospital of Dr. Mintohardjo Jakarta were meloxicam (48.21%, diclofenac sodium (31.07%, mefenamic acid (15.36%, piroxicam (3.93% dan acetaminophen (1.43%. Insiden of adverse event after 2 weeks treatment was significantly lower in the meloxicam group compared with diclofenac sodium group in pain in upper abdomen and upper abdominal bloating (p = 0.020 and p = 0.037. These result suggest that meloxicam was much better tolerated than diclofenac sodium after 2 weeks treatment.

  5. 单一应用磷酸钠盐口服溶液在大肠癌术前肠道准备中的临床观察%Clinical observation of single oral sodium phosphate in preoperative bowel preparation for colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    袁强; 杜峻峰; 陈光; 徐一石; 魏晓军; 孙亮; 苑树俊; 陈纲; 于波

    2011-01-01

    目的 探讨单一应用磷酸钠盐口服溶液在大肠癌术前肠道准备中的清洁效果、不良反应和耐受性.方法 将212例需做术前肠道准备的大肠癌患者随机分为四组:A组53例,口服磷酸钠盐口服溶液;;B组55例,口服磷酸钠盐口服溶液联合磷酸钠盐灌肠液肛人;C组51例口服聚乙二醇电解质溶液;D组53例,口服硫酸镁溶液.观察4种不同肠道准备方法的肠道清洁有效率、不良反应率和耐受性.结果 A组患者的肠道清洁有效率显著优于C组(P=0.031),而与B组、D组相比均无统计学差异(P>0.05).A组患者在腹胀及恶心发生率方面显著低于D组(P =0.037,0.008),而在腹痛、腹胀、恶心、呕吐方面A组与B组、C组相比均无统计学差异(P>0.05),A组患者的耐受性显著优于D组(P=0.001),而与B组、C组比较均无统计学差异(P =0.570,0.379).结论 单一应用磷酸钠盐口服溶液用于大肠癌术前肠道准备的肠道清洁有效率高,且不良反应少,患者耐受性好.%Objective To explore the cleaning efficacy, tolerahility and safety of single oral sodium phosphate in preoperative bowel preparation for colorectal cancer.Methods 212 patients who underwent the operation of colorectal cancer were randomly divided into four groups: A, B, C and D.In A group, 53 eases took single oral sodium phosphate.In B group, 55 casos were given the combination of omi sodium phosphate and sodium phosphate clyster.51 cases took polyethylene glycol solution (PEG) in group C,and 53 eases was administrated magnesium sulfate in group D.The cleaning efficacy, tolerability and safety were evaluated after bowel preparation.Results The cleaning efficacy of A group was significantly superior to that of B group ( P = 0.031 ), however no statistical difference was observed as compared with B or C group ( P > 0.05 ).The incidence rate of bellyache, bloating and nausea in A group were all lower than those of D group(P =0.037,0.008).However, with

  6. The wisdom of the deep south of Thailand: Case study on utilization of herbal medicine to treat domestic animal diseases by traditional doctors in Pattani, Yala and Narathiwat

    Directory of Open Access Journals (Sweden)

    Poh-etae A.

    2007-03-01

    used; to treat conjunctivitis, chilli (2.3% was used; and to treat broken bones, Alocasia macrorrhizos (2.3% was used.The pharmacopeia herbal medicine used to treat domestic animal diseases by traditional doctors were reported as follows: Blumea balasamifera leaves mixed with bullet wood flower (1.5% was used to treat bloat; mangosteen skin mixed with calcium hydroxide - Ca(OH2 (2.5% was used to treat deep wounds from foot and mouth disease.The most popular herbal medicine used by most traditional doctors in the pharmacopeia to treat diarrhea Tinospora crispa (50.0% was the most popular, followed by curcuma rhizomes (30.0% and Andrographis paniculata (20.0%; to treat bloat, Blumea balasamifera leaves or salt or cattle bone (22.2% was used; to treat worms in intestines, salt (25.0% was used; as an expectorant, Tinospora crispa or curcuma rhizomes (66.7% was used; to treat abscess, lime (100.0% was used to treat deep wounds from foot and mouth disease, curcuma rhizomes (66.7% came first, followed by Zingiber cassumunar or salt (33.3% and to chase away insects, curcuma rhizomes (50.0% came first, followed by vegetable oils or betel nuts or tobacco (33.3%.

  7. Effects of different ratios of white clover to lotus pedunculatus on rumen foam and gas production of Yanbian cattle%白三叶与长柄百脉根不同混合比例对延边黄牛瘤胃泡沫及产气的影响

    Institute of Scientific and Technical Information of China (English)

    张帆; 李成云; 吕忠蕾

    2013-01-01

    This experiment was designed to prevent rumen bloat, easily caused by feeding ruminants with high protein feed, from occurring effectively. Adding different ratio of the white clover to lotus pedunculatus (2:1, 2:2, 2:3 and 2:4) to rumen liquid, and then measured the weight of dry matter, soluble protein, foam production (cc), gas production and the changes of condensed tannins after cultured for 24 h. The results indicated that soluble condensed tannin and fiber bound condensed tannin decreased in different treatments, in addition, soluble condensed tannin reduced while protein bound condensed tannin increased reversely. When the ratio was 2:3, foam production (cc) decreased significantly compared with treatment with white clover alone, along with the increasement of lotus pedunculatus, the production of CO2 was decreased. In conclusion, the soluble condensed tannin in lotus pedunculatus was able to bind soluble protein and then converted into protein bound condensed tannin. This course can prevent the produce of foam and occurrence of rumen bloat as well as protect the undegradation protein. In order to get the significant effect, the lowest ratio of tannin containing forages in high protein forages was 2:2.%蛋白含量高的豆科牧草及高蛋白饲料饲喂反刍动物时易发生臌胀病,为有效防止臌胀病的发生,试验用4种不同比例的白三叶和长柄百脉根(分别为2∶1、2∶2、2∶3、2∶4)添加延边黄牛瘤胃液培养24h后测量干物质重、可溶性蛋白质、泡沫生成量(cc)、气体生成量及缩合单宁变化来比较差异.培养24h后,各处理中水溶性缩合单宁和纤维结合单宁减少,而蛋白结合单宁增加.白三叶与长柄百脉根比例为2∶3时比单独的白三叶处理时泡沫产生量显著减少;随着长柄百脉根的添加,CO2产量显著减少.这些结果表明,长柄百脉根内水溶性缩合单宁与可溶性蛋白结合转变为蛋白结合单宁,从而减少瘤胃内泡沫

  8. Analysis on the Lower Lumbar Fracture Postoperative Abdominal Distention Causes and Preventive Measures%下腰椎骨折术后腹胀原因分析及治疗探讨

    Institute of Scientific and Technical Information of China (English)

    唐永刚; 夏根; 贾瑞; 乔永东

    2012-01-01

      目的:对下腰椎骨折患者术后腹胀的临床原因进行分析,探讨预防及治疗腹胀的临床措施。方法:回顾笔者所在医院脊柱骨科546例下腰椎骨折患者的临床资料,并对脊髓损伤类型进行分类,分析脊髓损伤程度与腹胀的关系及不同下腰椎椎体节段与腹胀的关系,并对腹胀的原因及防治措施进行分析。结果:术前Frankel分级B级腹胀患者33例、C级63例、D级94例、E级197例,L3腹胀患者为190例、L4为125例、L5为72例,术后随访总患者Frankel分级,B级患者38例、C级78例、D级144例、E级286例,L3腹胀患者为245例、L4为176例、L5为125例。结论:对下腰椎骨折术后腹胀的原因及防治措施加以分析研究,有利于防止下腰椎骨折术后腹胀的发生,也利于提高腹胀发生后的处理水平,更利于患者的早日康复。%  Objective:The lower lumbar spine fractures in patients with postoperative abdominal distention clinical analysis,to investigate the clinical measures of prevention and treatment of abdominal distension.Method:Review 546 cases of hospital Spinal Orthopedic vertebral fracture patients,387 patients with a history of abdominal distension,and type of spinal cord injury classification,analysis of spinal cord injury and bloating, and the lower lumbar vertebral segments and the belly the expansion of relations,and abdominal distension.Result:Preoperative Frankel grade B bloating in patients with 33 cases,63 cases of class C,D in 94 cases,the E-Class 197 cases,L3 abdominal distension in patients with 190 cases,L4 125 cases,L5 72 patients were followed up patients with total Frankelgrade B patients and 38 cases,78 cases of class C,D in 144 cases,286 cases of E-Class, L3 abdominal distension in patients with 245 cases,L4 176 cases,and L5 125.Conclusion:Relationship between the degree of spinal cord loss and abdominal distension,and pedicle fixation,to prevent urinary retention and infection

  9. 铝碳酸镁片联合莫沙必利治疗胆汁反流性胃炎疗效的Meta分析%Meta Analysis of Hydrotalcite Tablets Combined with Mosapride for Treating Bile Reflux Gastritis

    Institute of Scientific and Technical Information of China (English)

    谢日升; 曾光

    2016-01-01

    目的:利用循证医学方法,系统评价铝碳酸镁片联合莫沙必利治疗胆汁反流性胃炎的疗效及上腹部饱胀不适缓解率。方法通过计算机检索中文数据库,收集铝碳酸镁片联合莫沙必利片治疗胆汁反流性胃炎临床研究。按纳入及排除标准筛选文献,由2位评价者筛选文献、提取资料并行方法学质量评价,数据分析采用Revman 5.1软件,通过检验异质性,并根据异质性结果选择相应的效应模型,最后绘制漏斗图评定有无发表偏倚。结果治疗组临床治疗有效率[ RR=1.20,95% CI (1.15,1.25)]、上腹饱胀不适缓解率[ MD=-0.38,95% CI (-0.71,-0.05)]方面均优于对照组,两组差异均有统计学意义。结论现有证据表明,铝碳酸镁片联合莫沙必利在治疗胆汁反流性胃炎上有一定疗效。%Objective To systematically evaluate the efficacy and improvement of bloating remission rate of Hydrotalcite Tablets combined with mosapride in the treatment of bile reflux gastritis. Methods The data of the Chinese database were retrieved for clinical trials of hydrotalcite combined with mosapride in treating bile reflux gastritis. According to inclusion and exclusion criteria, 2 reviewers performed the screening, data extraction, and methodological quality assessment. Revman 5. 1 software was used to perform data analysis, by checking the heterogeneity and heterogeneity of the results based on selection the corresponding effects model, to finally draw the funnel for as-sessing whether the publication bias. Results According to the results of meta-analyses, the trial groups were better than the control groups in terms of overall efficacy [ RR=1. 20, 95% CI:1. 15, 1. 25 ] , rate of bloating remission [ MD= -0. 38, 95% CI: -0. 71, -0. 05 ] , with statistically significant difference. Conclusion The results show that Hydrotalcite Tablets combined with mosapride is effective in the treatment of

  10. 微量喂养联合抚触疗法改善早产儿喂养不耐受疗效观察%The effect of micro-feeding combined with massage therapy in improving the feeding intolerance in preterm infant

    Institute of Scientific and Technical Information of China (English)

    安转芹

    2015-01-01

    目的::观察微量喂养联合抚触疗法改善早产儿喂养不耐受的临床效果。方法:将66例早产儿随机分为对照组和观察组,各33例。2组患儿入院后常规置于暖箱保暖、心电监护、防治感染、维持内环境稳定、静脉营养支持及对症治疗。对照组将早产儿配方奶置于奶瓶中经其吸吮橡胶奶头喂养;观察组在常规治疗的基础上给予微量喂养:生后24 h内视患儿病情酌情给予非营养性吸吮或滴管喂养、留置胃管饲早产儿配方奶等办法,同时坚持给患儿进行抚触疗法。比较2组患儿腹胀和胃潴留消失时间、恢复到出生体质量的时间以及喂养不耐受发生率。结果:观察组患儿较对照组腹胀和胃潴留消失时间缩短、恢复到出生体质量的时间明显缩短、喂养不耐受发生率降低(P<0.01)。结论:微量喂养联合抚触疗法可明显降低早产儿喂养不耐受发生率,有利于早产儿尽早达到全肠道内营养及生长发育需求。适宜的喂养方法对提高基层医院早产儿救治水平具有重要意义。%Objective:To observe the clinical effects of micro-feeding combined with massage therapy in improving the feeding intolerance in preterm infants. Methods:Sixty-six preterm infants were randomly divided into the observation group and control group (33 cases each group). Two groups were treated with keeping warm,monitoring electrocardiogram,preventing infection,maintaining homoiostasis,supporting parenteral nutrition and dealing with symptoms. The control group were fed using milk bottle, and the observation group were additionally fed with micro-feeding. The preterm infants were treated with non-nutritive sucking or eyedropper feeding,indwelling gastric tube feeding and massage therapy within 24 hours after birth. The time of the bloating, gastric retention disappear and recovering birth weight,and incidence of feeding intolerance between two groups were

  11. Arthropod succession on pig carcasses in southeastern Nigeria

    Directory of Open Access Journals (Sweden)

    M.S. Ekanem

    2010-01-01

    Full Text Available The domestic pig (Sus scrofa was used as a model to study arthropod succession on carcasses under tree shade and out of shade in southern Nigeria. Carcass decomposition took longer periods under tree shade than in exposed sites, at 24.5 and 16.5 days, respectively. Four decomposition stages - fresh, bloated, decay, and dry - were observed. No significant variabilities were recorded in the types and patterns of infestation of the carcasses by arthropods in both locations. Four classes of arthropods - Insecta, Arachnida, Diplopoda and Crustacea - were recorded. The class Insecta dominated the total arthropods collected with 24 families, and formed 94% of the catches. The other three classes each had one family represented, and contributed only 2% of the total catches. The calliphorids, a phorid, and sarcophagids arrived and bred on the carcasses only a few hours after death of the pigs. Families of coleopterans came during the bloated stage, and fed on the immature dipterous maggots and carrion materials. The ants (Hymenoptera came in large numbers to eat the carcasses, and also preyed on all other fauna of the food resource. A muscid and a stratiomyiid, bred on the carcass as to the decay stage. Other insects and arthropods arrived mostly during the decay stage to feed on the carcasses. Species richness on the carcasses peaked during the decay stage.O porco branco (Sus scrofa foi usado como modelo para o estudo da sucessão de Artrópodes em cadáveres em zonas sombreadas e não sombreadas por árvores no sul da Nigéria. Nos cadáveres em decomposição em zonas sombreadas observou-se um processo de decomposição mais lento que nos expostos ao sol; 24,5 e 16,5 dias, respectivamente. Foram observadas quatro etapas de decomposição; fresco (autólise, intumescido (putrefação, deteriorado e seco (diagênese. Não foram observadas diferenças significativas de tipo e padrão nas infestações dos cadáveres por Artrópodes em ambas as condi

  12. Study on Chinese diet therapy combined with domperidone applied in recovery of gastrointestinal function in oral cancer patients with nasal feeding after surgery%中医食疗配合多潘立酮在口腔癌术后鼻饲病人胃肠功能恢复中的应用研究

    Institute of Scientific and Technical Information of China (English)

    范玉霞; 阳静; 李晓霞; 曾定芬

    2016-01-01

    Objective:To probe into the application effect of Chinese food therapy combined with domperidone for the gastrointestinal recovery of oral cancer patients with nasal feeding after surgery.Methods:A total of 50 pa-tients with nasal feeding following oral cancer surgery were included in this study.These patients were random-ly divided into either the routine therapy group (control group,no Chinese food therapy)or the Chinese food therapy group(25 patients in each group).One day after surgery,the patients in control group were provided basic care(e.g.,intermittent gastrointestinal decompression and the nasal feeding of liquids)and the nasal feed-ing of domperidone.The patients in Chinese food therapy group were provided basic care,domperidone,and Chi-nese food therapy.Appetite,bloating,gastric retention,and the time to first stool passing after surgery were compared between the two groups.Results:Appetite,bloating and gastric retention were significantly improved on second day to 7th after surgery in Chinese food therapy group compared with control group(P <0.05),and the time to first stool passing after surgery was significantly shorter in Chinese food therapy group than that in control group(P <0.05).Conclusions:Patients with nasal feeding after oral cancer surgery showed varying de-grees of gastrointestinal dysfunction,and Chinese food therapy combined with domperidone was more effective at promoting gastrointestinal recovery.%[目的]探讨中医食疗配合多潘立酮在口腔癌术后鼻饲病人胃肠功能恢复中的应用效果。[方法]选取50例口腔癌术后鼻饲病人,按接受中医食疗与否区组随机化分为常规组、食疗组各25例,于术后第1日,常规组给予间断胃肠减压、管喂流质等基础护理,同时管喂多潘立酮;食疗组在常规组基础上给予中医食疗措施。比较两组病人术后食欲、腹胀、胃潴留量以及首次大便时间。[结果]食疗组病人术后第2日~第7日食欲、

  13. Maximum tolerated volume in drinking tests with water and a nutritional beverage for the diagnosis of functional dyspepsia

    Institute of Scientific and Technical Information of China (English)

    Aldo Monta(n)o-Loza; Max Schmulson; Sergio Zepeda-Gómez; Jose Maria Remes-Troche; Miguel Angel Valdovinos-Diaz

    2005-01-01

    AIM: Recently, drinking load tests with water or nutritional beverages have been proposed as diagnostic tools for functional dyspepsia (FD), therefore we sought to reproduce if these tests can discriminate between FD patients and controls in a Mexican population. METHODS: Twenty FD-Rome Ⅱ patients were matched by age and gender with 20 healthy controls. All underwent both drinking tests at a 15 mL/min rate, randomly, 7 d apart. Every 5 min within each test, four symptoms were evaluated (satiety, bloating, nausea and pain) by Likert scales. Maximum tolerated volume (MTV) was defined as the ingested volume when a score of 5 was reached for any symptom or when the test had to be stopped because the patients could not tolerate more volume. Sensitivity and specificity were analyzed. RESULTS: FD patients had higher symptom scores for both tests compared to controls (water: t= 4.1, P= 0.001 <0.01; Nutren(R): t= 5.2, P= 0.001<0.01). The MTV forwater and Nutren(R) were significantly lower in FD (water: 1014±288 vs 1749±275 mL; t = 7.9, P = 0.001<0.01;Nutren(R): 652±168 vs 1278±286 mL; t= 6.7, P = 0.001<0.01). With the volume tolerated by the controls, the percentile 10 was determined as the lower limit fortolerance. Sensitivity and specificity were 0.90, 0.95 for water and 0.95, 0.95 for Nutren(R) tests.CONCLUSION: A drinking test with water or a nutritional beverage can discriminate between FD patients and healthy subjects in Mexico, with high sensitivity and specificity. These tests could be used as objective, noninvasive, and safe diagnostic approaches for FD patients.

  14. Hormonal treatment for endometriosis associated pelvic pain

    Directory of Open Access Journals (Sweden)

    Wu Shun Felix Wong

    2011-01-01

    Full Text Available AbstractBackground: Endometriosis is a common gynecological problem associated with chronic pelvic pain. Objective: To evaluate the effectiveness of current hormonal treatments of endometriosis associated pain.Materials and Methods: Randomized Controlled studies identified from databases of Medline and Cochrane Systemic Review groups were pooled. 7 RCTs were recruited for evaluation in this review. Data from these studies were pooled and meta-analysis was performed in three comparison groups: 1 Progestogen versus GnRHa; 2 Implanon versus Progestogen (injection; 3 Combined oral contraceptive pills versus placebo and progestogen. Response to treatment was measured as a reduction in pain score. Pain improvement was defined as improvement ≥1 at the end of treatment. Results: There was no significant difference between treatment groups of progestogen and GnRHa (RR: 0.036; CI:-0.030-0.102 for relieving endometriosis associated pelvic pain. Long acting progestogen (Implanon and Mirena are not inferior to GnRHa and depot medroxy progesterone acetate (DMPA (RR: 0.006; CI:-0.142-0.162. Combined oral contraceptive pills demonstrated effective treatment of relieving endometriosis associated pelvic pain when compared with placebo groups (RR:0.321CI-0.066-0.707. Progestogen was more effective than combined oral contraceptive pills in controlling dysmenorrhea (RR:-0.160; CI:-0.386-0.066, however, progestogen is associated with more side effects like spotting and bloating than the combined contraceptive pills. Conclusion: Combined oral contraceptive pills (COCP, GnRHa and progestogens are equally effective in relieving endometriosis associated pelvic pain. COCP and progestogens are relatively cheap and more suitable for long-term use as compared to GnRHa. Long-term RCT of medicated contraceptive devices like Mirena and Implanon are required to evaluate their long-term effects on relieving the endometriosis associated pelvic pain

  15. Spirulina and Pentoxyfilline – A Novel Approach for Treatment of Oral Submucous Fibrosis

    Science.gov (United States)

    Mulk, Bhavana Sujana; Deshpande, Prasannasrinivas; Velpula, Nagalakshmi; Chappidi, Vani; Chintamaneni, Raja Lakshmi; Goyal, Stuti

    2013-01-01

    Background: Oral submucous fibrosis is a habit associated insidious precancerous condition of the oral cavity commonly found in Asian countries. Many treatment modalities have been attempted in treating the condition apart from steroids which have been the main stay. Hence the present study was designed to assess the efficacy of spirulina and pentoxyfilline and also to compare them in oral submucous fibrosis. Material and Methods: Fourty Patients with clinico-histological diagnosis of oral sub mucous fibrosis were selected and divided into two groups with 20 in each group by simple randomization method. Group I received Pentoxyfilline and Group II Spirulina for period of 3 months. The efficacy was assessed by parameters like mouth opening, burning sensation and tongue protrusion using vernier caliper, visual analog scale and a metric scale respectively along with the side effects. Results: Student’s t-test was applied to obtain the results. Both Pentoxyfilline and Spirulina groups showed statistically significant results (p=0.000) in all the three parameters namely mouth opening, burning sensation and tongue protrusion. On comparing both the drugs statistically insignificant results were obtained for mouth opening (p=0.35) and tongue protrusion (p=0.25) but statistically significant difference was seen in subjective parameter i.e burning sensation (p=0.04). Side effects like bloating of stomach, nausea and gastritis were noted in the pentoxyfilline group in contrast to Spirulina group. Conclusion: Newer drugs Pentoxyfilline and Spirulina showed promising results in treatment of Oral sub mucous fibrosis. Spirulina was used for the first time for treatment of Oral submucous fibrosis (OSMF) and it proved to be superior than pentoxyfilline as no side effects were observed. Also it was superior in reducing burning sensation and hence can be advised in OSMF patients suffering from severe subjective symptoms. PMID:24551724

  16. Magnetic resonance enterography or video capsule endoscopy – what do Crohn’s disease patients prefer?

    Science.gov (United States)

    Lahat, Adi; Kopylov, Uri; Amitai, Marianne M; Neuman, Sandra; Levhar, Nina; Yablecovitch, Doron; Avidan, Benjamin; Yanai, Henit; Dotan, Iris; Chowers, Yehuda; Weiss, Batya; Ben-Horin, Shomron; Eliakim, Rami

    2016-01-01

    Background Despite differences in the information obtained by capsule endoscopy (CE) and magnetic resonance enterography (MRE), one of these modalities is usually needed when evaluating disease activity. There are no data on patients’ preference that would help guide the choice between these two modalities in these instances. Aim To compare patients’ tolerance and preference to MRE versus CE. Patients and methods Patients with known small bowel Crohn’s disease (CD) in clinical remission (Crohn’s disease activity index [CDAI] <150) or with mild symptoms (CDAI <220) were prospectively recruited. All patients underwent MRE followed by CE. Patients were asked to fill out a questionnaire addressing specific points regarding inconvenience during the preparation for the procedures, the procedures, and postprocedures. Side effects and procedure preference were addressed. Questionnaires were included for analysis only when more than 95% of the items were addressed. Results Fifty-six patients fulfilled inclusion criteria. Pre-exam discomfort, during-exam discomfort, nausea, vomiting, bloating, and abdominal pain were all significantly more prominent in MRE as compared to CE (P<0.0001, P<0.0001, P<0.0001, P=0.009, P=0.0002, P<0.0001, respectively). MRE was perceived as a more difficult procedure (P<0.0001). Furthermore, MRE was associated with a specific adverse event – claustrophobia. Seventy-eight percent of patients (44 patients) preferred to repeat CE as compared to 22% (P<0.0001) who preferred MRE. Conclusion CE was better tolerated by CD patients compared to MRE and was preferred by 78% of patients. The superior tolerability of CE should be considered along with the diagnostic features, and more data sought when choosing between these two modalities for CD patients for long-term follow-up. PMID:27354774

  17. No evidence of harms of probiotic Lactobacillus rhamnosus GG ATCC 53103 in healthy elderly-a phase I open label study to assess safety, tolerability and cytokine responses.

    Directory of Open Access Journals (Sweden)

    Patricia L Hibberd

    Full Text Available BACKGROUND: Although Lactobacillus rhamnosus GG ATCC 53103 (LGG has been consumed by 2 to 5 million people daily since the mid 1990s, there are few clinical trials describing potential harms of LGG, particularly in the elderly. OBJECTIVES: The primary objective of this open label clinical trial is to assess the safety and tolerability of 1×1010 colony forming units (CFU of LGG administered orally twice daily to elderly volunteers for 28 days. The secondary objectives were to evaluate the effects of LGG on the gastrointestinal microbiome, host immune response and plasma cytokines. METHODS: Fifteen elderly volunteers, aged 66-80 years received LGG capsules containing 1×1010 CFU, twice daily for 28 days and were followed through day 56. Volunteers completed a daily diary, a telephone call on study days 3, 7 and 14 and study visits in the Clinical Research Center at baseline, day 28 and day 56 to determine whether adverse events had occurred. Assessments included prompted and open-ended questions. RESULTS: There were no serious adverse events. The 15 volunteers had a total of 47 events (range 1-7 per volunteer, 39 (83% of which were rated as mild and 40% of which were considered related to consuming LGG. Thirty-one (70% of the events were expected, prompted symptoms while 16 were unexpected events. The most common adverse events were gastrointestinal (bloating, gas, and nausea, 27 rated as mild and 3 rated as moderate. In the exploratory analysis, the pro-inflammatory cytokine interleukin 8 decreased during LGG consumption, returning towards baseline one month after discontinuing LGG (p = 0.038 while there was no difference in other pro- or anti-inflammatory plasma cytokines. CONCLUSIONS: Lactobacillus rhamnosus GG ATCC 53103 is safe and well tolerated in healthy adults aged 65 years and older. TRIAL REGISTRATION: ClinicalTrials.gov NCT 01274598.

  18. An atypical case of infection by Clostridium difficile

    Directory of Open Access Journals (Sweden)

    Maria Cristina Neri

    2010-09-01

    Full Text Available Clostridium difficile is a Gram-positive human pathogenic bacterium and nosocomial pathogen; it is the causative agent diarrhoea, colitis and pseudo-membranous colitis associated with antibiotic therapy. The pathogenesis of diarrhoea linked to a Clostridium difficile infection is complex and only partly know. A 75 years old subject with biventricular defibrillator for atrial flutter-fibril slow dilated cardiomyopathy underwent, in february 2008, surgery of mitro-aortic replacement.The subject, in march 2009, followed a rehabilitation therapy with aspirin and esomeprazole, as an outpatient, to Pio Albergo Trivulzio. The patient appeared lucid, oriented in time and space, in good general conditions; objectivity shows mild abdominal bloating, rectal examination negative; reported bowel function tend constipated with 1-2 bowel movements per week with formed stools and recent episodes of melena. Blood tests showed anemia and positive research haemoglobin in stool.The patient underwent esophagogastroduodenoscopy and then rettosigmoidoscopia, and decided to carry out biopsies. The sigmoid-rectal endoscopic picture was compatible with a diagnosis of “pseudo-membranous colitis hospitalization, On the basis of symptoms reported was required to search for toxins and bacterial culture for Clostridium difficile, resulting both positive. In literature are reported with increasing frequency of Clostridium difficile associated diarrhoea in patients home. The clinical case presented shows that in patients from home with symptoms vanished, the presence of formed stool does not exclude the possibility of infection by Clostridium difficile and is therefore useful and absolutely advisable to search for toxins and bacterial culture for Clostridium difficile.

  19. Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms.

    Directory of Open Access Journals (Sweden)

    Jonna Jalanka-Tuovinen

    Full Text Available BACKGROUND: While our knowledge of the intestinal microbiota during disease is accumulating, basic information of the microbiota in healthy subjects is still scarce. The aim of this study was to characterize the intestinal microbiota of healthy adults and specifically address its temporal stability, core microbiota and relation with intestinal symptoms. We carried out a longitudinal study by following a set of 15 healthy Finnish subjects for seven weeks and regularly assessed their intestinal bacteria and archaea with the Human Intestinal Tract (HIT Chip, a phylogenetic microarray, in conjunction with qPCR analyses. The health perception and occurrence of intestinal symptoms was recorded by questionnaire at each sampling point. PRINCIPAL FINDINGS: A high overall temporal stability of the microbiota was observed. Five subjects showed transient microbiota destabilization, which correlated not only with the intake of antibiotics but also with overseas travelling and temporary illness, expanding the hitherto known factors affecting the intestinal microbiota. We identified significant correlations between the microbiota and common intestinal symptoms, including abdominal pain and bloating. The most striking finding was the inverse correlation between Bifidobacteria and abdominal pain: subjects who experienced pain had over five-fold less Bifidobacteria compared to those without pain. Finally, a novel computational approach was used to define the common core microbiota, highlighting the role of the analysis depth in finding the phylogenetic core and estimating its size. The in-depth analysis suggested that we share a substantial number of our intestinal phylotypes but as they represent highly variable proportions of the total community, many of them often remain undetected. CONCLUSIONS/SIGNIFICANCE: A global and high-resolution microbiota analysis was carried out to determine the temporal stability, the associations with intestinal symptoms, and the

  20. Fecal microbiota transplantation for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients.

    Science.gov (United States)

    Webb, B J; Brunner, A; Ford, C D; Gazdik, M A; Petersen, F B; Hoda, D

    2016-08-01

    Recurrent Clostridium difficile infection (CDI) is a consequence of intestinal dysbiosis and is particularly common following hematopoietic stem cell transplantation (HSCT). Fecal microbiota transplantation (FMT) is an effective method of treating CDI by correcting intestinal dysbiosis by passive transfer of healthy donor microflora. FMT has not been widely used in immunocompromised patients, including HSCT recipients, owing to concern for donor-derived infection. Here, we describe initial results of an FMT program for CDI at a US HSCT center. Seven HSCT recipients underwent FMT between February 2015 and February 2016. Mean time post HSCT was 635 days (25-75 interquartile range [IQR] 38-791). Five of the patients (71.4%) were on immunosuppressive therapy at FMT; 4 had required long-term suppressive oral vancomycin therapy because of immediate recurrence after antibiotic cessation. Stool donors underwent comprehensive health and behavioral screening and laboratory testing of serum and stool for 32 potential pathogens. FMT was administered via the naso-jejunal route in 6 of the 7 patients. Mean follow-up was 265 days (IQR 51-288). Minor post-FMT adverse effects included self-limited bloating and urgency. One patient was suspected of having post-FMT small intestinal bacterial overgrowth. No serious adverse events were noted and all-cause mortality was 0%. Six of 7 (85.7%) patients had no recurrence; 1 patient recurred at day 156 post FMT after taking an oral antibiotic and required repeat FMT, after which no recurrence has occurred. Diarrhea was improved in all patients and 1 patient with gastrointestinal graft-versus-host disease was able to taper off systemic immunosuppression after FMT. With careful donor selection and laboratory screening, FMT appears to be a safe and effective therapy for CDI in HSCT patients and may confer additional benefits. Larger studies are necessary to confirm safety and efficacy and explore other possible effects.

  1. Addition of sodium bicarbonate to complete pelleted diets fed to dairy calves.

    Science.gov (United States)

    Wheeler, T B; Wangsness, P J; Muller, L D; Griel, L C

    1980-11-01

    During two trials, 35 and 27 Holstein calves were fed ad libitum complete, pelleted diets containing either 35% alfalfa (Trial 1) or 35% grass (Trial 2) hay from birth to 12 wk of age. Calves in Trial 1 were fed one of the following diets: control, control + 3.5% sodium chloride, or control + 5% sodium bicarbonate. In Trial 2, diets were: control, control + 5% sodium bicarbonate, or control + 5% sodium bicarbonate + loose, chopped grass hay. Intake of dry matter, gain in body weight, ruminal pH, or fecal starch did not differ. Calves fed sodium bicarbonate in Trial 1 but not 2 had a reduced feed efficiency compared with control and supplemented diets. In Trial 1 added sodium bicarbonate did not alter intake or digestible energy. Addition of sodium bicarbonate increased concentration of ruminal acetate and butyrate and decreased propionate in both trials. Fecal pH was elevated in calves fed sodium bicarbonate diets during both trials. Sodium chloride increased water intake in Trial 1, and sodium bicarbonate increased water indigestible energy. Addition of sodium bicarbonate increased concentration of ruminal acetate and butyrate and decreased propionate in both trials. Fecal pH was elevated in calves fed sodium bicarbonate diets during both trials. Sodium chloride increased water intake in Trial 1, and sodium bicarbonate increased water indigestible energy. Addition of sodium bicarbonate increased concentration of ruminal acetate and butyrate and decreased propionate in both trials. Fecal pH was elevated in calves fed sodium bicarbonate diets during both trials. Sodium chloride increased water intake in Trial 1, and sodium bicarbonate increased water intake in Trial 2. Incidence of free-gas bloat was higher in calves fed sodium bicarbonate in both trials. Addition of sodium bicarbonate to complete pelleted diets containing 35% alfalfa or 35% grass hay appeared to have no benefit for young, growing dairy calves in performance and health.

  2. Progressive retinal degeneration and glial activation in the CLN6 (nclf mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation.

    Directory of Open Access Journals (Sweden)

    Myriam Mirza

    Full Text Available Neuronal ceroid lipofuscinosis (NCL is a group of neurodegenerative lysosomal storage disorders characterized by vision loss, mental and motor deficits, and spontaneous seizures. Neuropathological analyses of autopsy material from NCL patients and animal models revealed brain atrophy closely associated with glial activity. Earlier reports also noticed loss of retinal cells and reactive gliosis in some forms of NCL. To study this phenomenon in detail, we analyzed the ocular phenotype of CLN6 (nclf mice, an established mouse model for variant-late infantile NCL. Retinal morphometry, immunohistochemistry, optokinetic tracking, electroretinography, and mRNA expression were used to characterize retinal morphology and function as well as the responses of Müller cells and microglia. Our histological data showed a severe and progressive degeneration in the CLN6 (nclf retina co-inciding with reactive Müller glia. Furthermore, a prominent phenotypic transformation of ramified microglia to phagocytic, bloated, and mislocalized microglial cells was identified in CLN6 (nclf retinas. These events overlapped with a rapid loss of visual perception and retinal function. Based on the strong microglia reactivity we hypothesized that dietary supplementation with immuno-regulatory compounds, curcumin and docosahexaenoic acid (DHA, could ameliorate microgliosis and reduce retinal degeneration. Our analyses showed that treatment of three-week-old CLN6 (nclf mice with either 5% DHA or 0.6% curcumin for 30 weeks resulted in a reduced number of amoeboid reactive microglia and partially improved retinal function. DHA-treatment also improved the morphology of CLN6 (nclf retinas with a preserved thickness of the photoreceptor layer in most regions of the retina. Our results suggest that microglial reactivity closely accompanies disease progression in the CLN6 (nclf retina and both processes can be attenuated with dietary supplemented immuno-modulating compounds.

  3. Effect of titania on fired characteristics of triaxial porcelain

    Indian Academy of Sciences (India)

    Sunipa Bhattacharyya; Swapan Kumar Das; Nirendra Krishna Mitra

    2005-08-01

    Titania was progressively added in the range 3–9 wt% into a triaxial porcelain body consisting of clay, quartz and feldspar. The composed bodies were heated at five different temperatures in the range 1200–1400°C and their fired properties as well as phases evolved were studied. The results revealed that beyond 1300°C, formation of more liquid phases caused bloating in samples which led to generation of pores. This effect is more pronounced in TiO2 containing samples. In the present system, 1300°C appeared to be the optimum temperature at which porosity was almost negligible and strength was maximum (45 MPa), particularly in presence of TiO2. From the results of XRD studies, it was revealed that quartz content primarily decreased with increase in TiO2 content due to excess glass formation and its subsequent dissolution. Mullite content increased with increase in TiO2 content. No significant effect was observed beyond 6 wt% addition. Microstructure primarily showed the presence of quartz grain and cluster of smaller sized primary mullite crystals in both the samples without and with TiO2. Very few secondary mullite crystals were also observed. SEM picture of sample containing 9 wt% TiO2 showed some grain boundary crack due to cooling stress generated in the glassy phase. The drastic reduction of residual strength after 8 cycles of heating at 800°C and cooling particularly in TiO2 containing samples suggests controlled heat treatment of the vitrified samples necessary to promote secondary crystallization process for the enhancement of strength. Attempts have also been made to correlate the constitutional parameters with the properties.

  4. A dearth of short-period massive binaries in the young massive star forming region M 17. Evidence for a large orbital separation at birth?

    Science.gov (United States)

    Sana, H.; Ramírez-Tannus, M. C.; de Koter, A.; Kaper, L.; Tramper, F.; Bik, A.

    2017-03-01

    Aims: The formation of massive stars remains poorly understood and little is known about their birth multiplicity properties. Here, we aim to quantitatively investigate the strikingly low radial-velocity dispersion measured for a sample of 11 massive pre- and near-main-sequence stars (σ1D= 5.6 ± 0.2 km s-1) in the very young massive star forming region M 17, in order to obtain first constraints on the multiplicity properties of young massive stellar objects. Methods: We compute the radial-velocity dispersion of synthetic populations of massive stars for various multiplicity properties and we compare the obtained σ1D distributions to the observed value. We specifically investigate two scenarios: a low binary fraction and a dearth of short-period binary systems. Results: Simulated populations with low binary fractions () or with truncated period distributions (Pcutoff > 9 months) are able to reproduce the low σ1D observed within their 68%-confidence intervals. Furthermore, parent populations with fbin > 0.42 or Pcutoff star formation process. In the context of the second scenario, compact binaries must form later on, and the cut-off period may be related to physical length-scales representative of the bloated pre-main-sequence stellar radii or of their accretion disks. Conclusions: If the obtained constraints for the M 17's massive-star population are representative of the multiplicity properties of massive young stellar objects, our results may provide support to a massive star formation process in which binaries are initially formed at larger separations, then harden or migrate to produce the typical (untruncated) power-law period distribution observed in few Myr-old OB binaries.

  5. 吴茱萸结合酚妥拉明治疗婴幼儿肺炎合并腹胀的疗效观察%The Evodia combined phentolamine treatment of infantile pneumonia complicated by abdominal distension Efficacy

    Institute of Scientific and Technical Information of China (English)

    李世巧

    2013-01-01

    Objective Research Evodia combined with phentolamine treatment of infantile pneumonia complicated by abdominal distension therapeutic effect, and to develop the best treatment plan. Methods 90 cases of pneumonia complicated by abdominal distension were randomly divided into two groups, the experimental group, 45 cases of abdominal topical the Evodia combination of phentolamine intravenous drug treatment and control group 45 cases using only intravenous phentolamine treatment. Results The two sets of cure time difference was statistically significant (P <0.05). Conclusion Evodia combination of phentolamine treatment than simple intravenous phentolamine can be reached much more quickly to reduce bloating symptoms, found no adverse reactions.%目的研究吴茱萸结合酚妥拉明治疗婴幼儿肺炎合并腹胀的治疗效果,制定最佳治疗方案。方法将90例肺炎合并腹胀患儿随机分为2组,实验组45例采用腹部外敷吴茱萸结合酚妥拉明静脉用药治疗,对照组45例只采用静脉使用酚妥拉明治疗。结果两组治愈时间差异有统计学意义(P<0.05)。结论吴茱萸结合酚妥拉明治疗比单纯静脉使用酚妥拉明能更快达到减轻腹胀症状,未发现不良反应。

  6. Efficacy of the low FODMAP diet for treating irritable bowel syndrome: the evidence to date

    Directory of Open Access Journals (Sweden)

    Nanayakkara WS

    2016-06-01

    Full Text Available Wathsala S Nanayakkara,1 Paula ML Skidmore,1 Leigh O'Brien,2 Tim J Wilkinson,3 Richard B Gearry,31Department of Human Nutrition, University of Otago, Dunedin, New Zealand; 2Dietary Specialists, Christchurch, New Zealand; 3Department of Medicine, University of Otago, Christchurch, New Zealand Abstract: This review summarizes the published clinical studies concerning the management of irritable bowel syndrome (IBS using restriction of Fermentable Oligosaccharide, Disaccharide, Monosaccharide, and Polyols in the diet (low FODMAP diet. In recent years, the data supporting low FODMAP diet for the management of IBS symptoms have emerged, including several randomized controlled trials, case-control studies, and other observational studies. Unlike most dietary manipulations tried in the past to alleviate gastrointestinal symptoms of IBS, all studies on low FODMAP diet have consistently shown symptomatic benefits in the majority of patients with IBS. However, dietary adherence by the patients and clear dietary intervention led by specialized dietitians appear to be vital for the success of the diet. Up to 86% of patients with IBS find improvement in overall gastrointestinal symptoms as well as individual symptoms such as abdominal pain, bloating, constipation, diarrhea, abdominal distention, and flatulence following the diet. FODMAP restriction reduces the osmotic load and gas production in the distal small bowel and the proximal colon, providing symptomatic relief in patients with IBS. Long-term health effects of a low FODMAP diet are not known; however, stringent FODMAP restriction is not recommended owing to risks of inadequate nutrient intake and potential adverse effects from altered gut microbiota. In conclusion, the evidence to date strongly supports the efficacy of a low FODMAP diet in the treatment of IBS. Further studies are required to understand any potential adverse effects of long-term restriction of FODMAPs. Keywords: irritable bowel

  7. Highlights from the UEG Week Congress 2014: New Evidence and Novel Therapies for Irritable Bowel Syndrome

    Directory of Open Access Journals (Sweden)

    Caroline Charles

    2014-12-01

    Full Text Available Irritable bowel syndrome (IBS is a common gastrointestinal disorder that affects up to 15% of the European and North American population, and is characterised by abdominal pain, bloating sensations, cramping, constipation, and diarrhoea. Main subtypes of IBS include constipation-predominant IBS (IBS-C, diarrhoea-predominant IBS (IBS-D, and mixed diarrhoea and constipation-associated IBS (IBS-M. The pathophysiology of IBS is still unclear, but important factors such as alterations in the brain-gut axis, bacterial overgrowth in the intestines, increased paracellular permeability, disruptions in the immune system, and accrued visceral sensitivity have been suggested. While many therapies are available to treat the symptoms associated with IBS, on a symptom-by-symptom basis, there are few effective treatments for IBS itself, including linaclotide, which was approved 2 years ago in Europe but only for IBS-C. Additional disease-modifying therapies to slow disease progression or achieve remission are needed as this represents a substantial unmet need. New emerging data on the pathophysiology of IBS are certainly promising; better knowledge of the underlying mechanisms will help refine the management of IBS, both in terms of diagnosis with the development of biomarkers, and in terms of therapeutic management with new pharmacological targets. Additional treatment options will be welcome given the variety of disease subtypes and presentations. The United European Gastroenterology (UEG Week Congress, which was held in Vienna, Austria, 18th-22nd October 2014, was an excellent opportunity to share new findings on the pathophysiology and new clinical evidence and emerging therapies in the management of IBS. Selected abstracts received additional exposure through the “Posters in the Spotlight” session and the “Posters of Excellence” award; such abstracts will be developed in this review.

  8. Lactose intolerance – current state of knowledge

    Directory of Open Access Journals (Sweden)

    Edyta Mądry

    2010-09-01

    Full Text Available Lactase-phlorizin hydrolase (LCT, more commonly known as lactase, is an enzyme responsible for cleaving lactose into absorbable monosaccharides, glucose and galactose. LCT deficiency (hypolactasia – HL is caused by a decreased activity of LCT in the small intestinal villi and potentially results in lactose malabsorption what may lead to the development of clinical symptoms (diarrhea, bloating, flatulence and cramps andavoiding milk products in the diet. HL is the world’s most common enzyme deficiency in humans. HL exists in three distinct forms – congenital, primary and secondary. Adult type hypolactasia (ATH is the most common phenotype found in human. It is a genetically predetermined physiological condition inherited through an autosomal recessive mode which results in a decline of lactase activity after weaning. ATH is associated with the LCT -13910 C>T polymorphism worldwide, except in Africa. Lactase non-persistence has been observed in individuals with the C/C-13910 genotype, whereas lactase persistence in subjects with remaining allelic variants. Small intestine biopsy is the only diagnostic procedure allowing for the direct measurement of LCT activity, however due to its invasive nature it is hardly accepted by patients. Therefore, LCT status is often inferred simply by assessing the patient’s lactose digestion. A lactose tolerance test can be performed after lactose load and then measuring blood glucose concentration or breath hydrogen (preferably hydrogen and methane expiration. A genetic test of the C/T-13910 polymorphism is also available at present. It is a reliable method in excluding/confirming ATH predisposition. However, it definitely does not assess lactose tolerance or malabsorption.

  9. Research of Chinese Characters Sort in Address Book Based on Android Platform%基于Android平台的通讯录中文汉字的排序研究

    Institute of Scientific and Technical Information of China (English)

    王秀华; 霍振鹏; 张庚

    2014-01-01

    With the rapid development of mobile Internet, the Android platform has also been popularity. On the platform, the application become more and more perfect. Address book as a medium between people have become a essential application. And the display order of the contacts has become a hot topic which attracts developers’attention. The paper presents a new sorting method, with the help of ordering statements in the database, realizing the sorting of Chinese charters according to the pinyin initials with high efficiency. Avoiding the program bloated problem which caused by introducing the third-party Jar package, this method is convenient and efficient .%随着移动互联网的迅速发展,Android平台也得到迅速普及,该移动平台上的应用日臻完善。通讯录作为人们之间联系方式存放的介质,自然成为必不可少的应用。而其中联系人的显示顺序则成为了开发者备受关注的话题,提出了一种新的排序方法,借助数据库的排序语句,方便高效地实现了将汉字按照拼音首字母自增的方式进行排序,该方法使用起来便捷、高效,避免了程序中引入第三方jar包所导致的程序臃肿问题。

  10. Post epidemic giardiasis and gastrointestinal symptoms among preschool children in Bergen, Norway. A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Eide Geir E

    2010-03-01

    Full Text Available Abstract Background A surprisingly low number of children became ill with giardiasis during the large waterborne outbreak of Giardia lamblia in Bergen, Norway during autumn 2004. The aim of the present study was to evaluate the prevalence of giardiasis among exposed children one year after an outbreak and compare faecal carriage of Giardia and abdominal symptoms among exposed versus unexposed children one year after the epidemic. Methods Children between 1 and 6 years old were recruited from the local health care centres in Bergen municipality in the period between June 2005 and January 2006. One faecal sample per child was collected and examined for presence of Giardia with a rapid immunoassay antigen test, and parents were asked to answer a questionnaire. A total of 513 children participated, 378 in the group exposed to contaminated water, and 135 in the in the group not exposed. Results In the exposed group eleven children had been treated for giardiasis during the epidemic and none in the unexposed group. Giardia positive faecal tests were found in six children, all in the exposed group, but the difference between the groups did not reach statistical significance. All six Giardia positive children were asymptomatic. No differences were found between the groups regarding demographic data, nausea, vomiting, different odour from stools and eructation. However, the reported scores of abdominal symptoms (diarrhoea, bloating and stomach ache during the last year were higher in the exposed group than in the unexposed group. Conclusions A low prevalence of asymptomatic Giardia infection (1.7% was found among exposed children around one year after the epidemic (1.2% overall prevalence in the study. In the present setting, pre-school children were therefore unlikely to be an important reservoir for continued transmission in the general population.

  11. Prospective study of biofeedback retraining in patients with chronic idiopathic functional constipation

    Institute of Scientific and Technical Information of China (English)

    Jun Wang; Mao-Hong Luo; Qing-Hui Qi; Zuo-Liang Dong

    2003-01-01

    AIM: To determine the efficacy and long-term outcome of biofeedback treatment for chronic idiopathic constipation and to compare the efficacy of two modes of biofeedback (EMG-based and manometry-based biofeedback).METHODS: Fifty consecutive contactable patients included 8 cases of slow transit constipation, 36 cases of anorectic outlet obstruction and 6 cases of mixed constipation. Two modes of biofeedback were used for these 50 patients, 30 of whom had EMG-based biofeedback, and 20 had manometrybased biofeedback. Before treatment, a consultation and physical examination were done for all the patients, related information such as bowel function and gut transit time was documented, psychological test (symptom checkJist 90, SCL90)and anorectic physiological test and defecography were applied. After biofeedback management, all the patients were followed up. The Student′s t-test, chi-squared test and Logistic regression were used for statistical analysis.RESULTS: The period of following up ranged from 12 to 24months (Median 18 months). 70% of patients felt that biofeedback was helpful, and 62.5% of patients with constipation were improved. Clinical manifestations including straining, abdominal pain, bloating, were relieved, and less oral laxative was used. Spontaneous bowel frequency and psychological state were improved significantly after treatment. Patients with slow and normal transit, and those with and without paradoxical contraction of the anal sphincter on straining, benefited equally from the treatment. The psychological status rather than anorectal test could predict outcome. The efficacy of the two modes of biofeedback was similar without side effects.CONCLUSION: This study suggests that biofeedback has a long-term effect with no side effects, for the majority of patients with chronic idiopathic constipation unresponsive to traditional treatment. Pelvic floor abnormalities and transit time should not be the selection criteria for treatment.

  12. 早产儿早期微量喂养胃肠道不耐受情况分析%Preterm children early minimal feeding gastrointestinal intolerance Analysis

    Institute of Scientific and Technical Information of China (English)

    管惠彬

    2012-01-01

    Objective:To evaluate early minimal feeding in improving preterm children,vomiting,bloating,stoma ch bleeding and other gastrointestinal intolerance situation.Methods:112 preterm children were randomly divided into two groups,early minimal feeding and traditional feeding group (control group),compared two methods after feeding in preterm children,vomiting,abdominal distention,the incidence of stomach bleeding.Results: The early minimal feeding group,vomiting,abdominal distension,stomach bleeding and other aspects of disease was significantly lower than the control group (P<0.05),the difference was significant.Conclusion: Early minimal feeding of premature children can promote mature gastric Road, improve feeding intolerance, reduce feeding complications.%目的探讨早期微量喂养在改善早产儿呕吐,腹胀,胃出血等胃肠道不耐受情况.方法112例早产儿随机平均分成2组,早期微量喂养及传统喂养组(对照组),比较2种方法喂养后早产儿在呕吐,腹胀,胃出血的发病率.结果早期微量喂养组在呕吐,腹胀,胃出血等方面发病率明显低于对照组(P<0.05),差异具有显著性.结论早产儿早期微量喂养可以促进胃道成熟,改善喂养不耐受,减少喂养并发症.

  13. Effects of Rebamipide on Gastrointestinal Symptoms in Patients with Type 2 Diabetes Mellitus

    Science.gov (United States)

    Park, Sejeong; Park, So Young; Kim, Yu Jin; Hong, Soo Min; Chon, Suk; Oh, Seungjoon; Woo, Jeong-taek; Kim, Sung-Woon; Kim, Young Seol

    2016-01-01

    Background Gastrointestinal (GI) symptoms are common in patients with type 2 diabetes mellitus (T2DM). Rebamipide is an effective gastric cytoprotective agent, but there are few data on its usefulness in T2DM. The aim of this study is to evaluate the improvement of GI symptoms after rebamipide treatment in patients with T2DM. Methods Patients with T2DM and atypical GI symptoms were enrolled. They took rebamipide (100 mg thrice daily) for 12 weeks and filled out the diabetes bowel symptom questionnaire (DBSQ) before and after rebamipide treatment. The DBSQ consisted of 10 questions assessing the severity of GI symptoms by a 1 to 6 scoring system. Changes in the DBSQ scores before and after rebamipide treatment were analyzed to evaluate any improvements of GI symptoms. Results A total of 107 patients were enrolled, and 84 patients completed the study. The mean age was 65.0±7.8, 26 patients were male (24.8%), the mean duration of T2DM was 14.71±9.12 years, and the mean glycosylated hemoglobin level was 6.97%±0.82%. The total DBSQ score was reduced significantly from 24.9±8.0 to 20.4±7.3 before and after rebamipide treatment (P<0.001). The DBSQ scores associated with reflux symptoms, indigestion, nausea or vomiting, abdominal bloating or distension, peptic ulcer, abdominal pain, and constipation were improved after rebamipide treatment (P<0.05). However, there were no significant changes in symptoms associated with irritable bowel syndrome, diarrhea, and anal incontinence. No severe adverse events were reported throughout the study. Conclusion Rebamipide treatment for 12 weeks improved atypical GI symptoms in patients with T2DM. PMID:27098506

  14. Ingesting Isomaltulose Versus Fructose-Maltodextrin During Prolonged Moderate-Heavy Exercise Increases Fat Oxidation but Impairs Gastrointestinal Comfort and Cycling Performance.

    Science.gov (United States)

    Oosthuyse, Tanja; Carstens, Matthew; Millen, Aletta M

    2015-10-01

    Certain commercial carbohydrate replacement products include slowly absorbed carbohydrates such as isomaltulose. Few studies have investigated the metabolic effects of ingesting isomaltulose during exercise and none have evaluated exercise performance and gastrointestinal comfort. Nine male cyclists participated postprandially during three trials of 2-h steady-state (S-S) exercise (60%Wmax) followed by a 16 km time trial (TT) while ingesting 63 g·h-1 of either, 0.8:1 fructose: maltodextrin (F:M) or isomaltulose (ISO) or placebo- flavored water (PL). Data were analyzed by magnitude-based inferences. During S-S exercise, ISO and PL similarly increased plasma nonesterified fatty acid (NEFA) concentration (mean change ISO versus F:M: 0.18, 90%CI ±0.21 mmol·L-1, 88% likelihood) and fat oxidation (10, 90%CI ±9 g, 89% likelihood) while decreasing carbohydrate oxidation (-36, 90%CI ±30.2 g, 91% likelihood) compared with F:M, despite equal elevations in blood glucose concentration with ISO and F:M. Rating of stomach cramps and bloating increased progressively with ISO (rating: 0-90 min S-S, weak; 120 min S-S, moderate; TT, strong) compared with F:M and PL (0-120 min S-S and TT, very weak). TT performance was substantially slower with ISO (mean change: 1.5, 90%CI ±1.4 min, 94% likely harmful) compared with F:M. The metabolic response of ISO ingestion during moderate exercise to increase NEFA availability and fat oxidation despite elevating blood glucose concentration is anomalous for a carbohydrate supplement. However, ingesting isomaltulose at a continuous high frequency to meet the recommended carbohydrate replacement dose, results in severe gastrointestinal symptoms during prolonged or high intensity exercise and negatively affects exercise performance compared with fructose-maltodextrin supplementation.

  15. Comparative outcome of stapled trans-anal rectal resection and macrogol in the treatment of defecation disorders

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    Ivano Biviano; Danilo Badiali; Laura Candeloro; Fortunee Irene Habib; Massimo Mongardini; Angelo Caviglia; Fiorella Anzini; Enrico S Corazziari

    2011-01-01

    AIM: To prospectively assess the efficacy and safety of stapled trans-anal rectal resection (STARR) compared to standard conservative treatment, and whether preoperative symptoms and findings at defecography and anorectal manometry can predict the outcome of STARR. METHODS: Thirty patients (Female, 28; age: 51 ± 9 years) with rectocele or rectal intussusception, a defecation disorder, and functional constipation were submitted for STARR. Thirty comparable patients (Female, 30; age 53 ± 13 years), who presented with symptoms of rectocele or rectal intussusception and were treated with macrogol, were assessed. Patients were interviewed with a standardized questionnaire at study enrollment and 38 ± 18 mo after the STARR procedure or during macrogol treatment. A responder was defined as an absence of the Rome El diagnostic criteria for functional constipation. Defecography and recto-anal manometry were performed before and after the STARR procedure in 16 and 12 patients, respectively. RESULTS: After STARR, 53% of patients were re-sponders; during conservative treatment, 75% were responders. After STARR, 30% of the patients reported the use of laxatives, 17% had intermittent anal pain, 13% had anal leakage, 13% required digital facilitation, 6% experienced defecatory urgency, 6% experienced fecal incontinence, and 6% required re-intervention. During macrogol therapy, 23% of the patients complained of abdominal bloating and 13% of borborygmi, and 3% required digital facilitation.No preoperative symptom, defecographic, or manometric finding predicted the outcome of STARR. Post-operative defecography showed a statistically significant reduction (P < 0.05) of the rectal diameter and rectocele. The postoperative anorectal manometry showed that anal pressure and rectal sensitivity were not significantly modified, and that rectal compliance was reduced (P = 0.01). CONCLUSION: STARR is not better and is less safe than macrogol in the treatment of defecation disorders. It

  16. INTOXICAÇÃO POR CESTRUM INTERMEDIUM EM BOVINOS NO MUNICÍPIO DE ITAPIRANGA SANTA CATARINA

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    VISNIESKI, Cleberson

    2015-04-01

    Full Text Available Cestrum intermedium poisoning is frequent cause of death for livestock in southern Brazil. This report served to describe a case in a property where four animals aged less than twelve months had clinical signs of acute poisoning, bloat and nerve signals. These animals came to death in less than twelve hours after the onset of clinical signs. According to the findings of macroscopic lesions during necropsy, histopathological changes of the material collected, consistent with the framework of acute intoxication, and, along with the presence of the plant on site, confirmed the diagnosis of acute intoxication by hepatotoxic plant. A intoxicação por Cestrum intermedium é frequente causa de morte de animais de produção na região sul do Brasil. O presente relato serviu para descrever um caso numa propriedade onde quatro animais com idade inferior a doze meses apresentavam sinais clínicos agudos de intoxicação, timpanismo e sinais nervosos. Estes animais vieram a óbito em menos de doze horas desde o surgimento dos sinais clínicos. De acordo com os achados de lesões macroscópicas durante a necropsia, alterações histopatológicas do material colhido, compatíveis com quadro de intoxicação aguda, e, juntamente com a presença da planta no local, confirmou-se o diagnóstico de intoxicação aguda por planta hepatotóxica.

  17. Self-Reported Prevalence of Symptomatic Adverse Reactions to Gluten and Adherence to Gluten-Free Diet in an Adult Mexican Population

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    Noe Ontiveros

    2015-07-01

    Full Text Available The prevalence of symptomatic adverse reactions to gluten and adherence to gluten-free diet in Latin American countries is unknown. These measurements are strongly linked to gluten-related disorders. This work aimed to estimate the prevalence of adverse reactions to oral gluten and the adherence to gluten-free diet in the adult Mexican population. To reach this aim, a self-administered questionnaire was designed and tested for clarity/comprehension and reproducibility. Then, a self-administered questionnaire-based cross-sectional study was conducted in the Mexican population. The estimated prevalence rates were (95% CI: 11.9% (9.9–13.5 and 7.8 (6.4–9.4 for adverse and recurrent adverse reactions to gluten respectively; adherence to gluten-free diet 3.7% (2.7–4.8, wheat allergy 0.72% (0.38–1.37; celiac disease 0.08% (0.01–0.45, and NCGS 0.97% (0.55–1.68. Estimated pooled prevalence of self-reported physician-diagnosis of gluten-related disorders was 0.88% (0.49–1.5, and 93.3% respondents reported adherence to gluten-free diet without a physician-diagnosis of gluten-related disorders. Symptom comparisons between those who reported recurrent adverse reactions to gluten and other foods showed statistically significant differences for bloating, constipation, and tiredness (p < 0.05. Gluten-related disorders may be underdiagnosed in the Mexican population and most people adhering to a gluten-free diet are doing it without proper diagnostic work-up of these disorders, and probably without medical/dietician advice.

  18. Small intestinal bacterial overgrowth and lactose intolerance contribute to irritable bowel syndrome symptomatology in Pakistan

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    Javed Yakoob

    2011-01-01

    Full Text Available Background /Aim: The symptoms of irritable bowel syndrome resemble those of small intestinal bacterial overgrowth (SIBO. The aim of this study was to determine the frequency of SIBO and lactose intolerance (LI occurrence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D according to Rome III criteria. Patients and Methods: In this retrospective case-control study, patients over 18 years of age with altered bowel habit, bloating, and patients who had lactose Hydrogen breath test (H 2 BT done were included. The "cases" were defined as patients who fulfill Rome III criteria for IBS-D, while "controls" were those having chronic nonspecific diarrhea (CNSD who did not fulfill Rome III criteria for IBS-D. Demographic data, predominant bowel habit pattern, concurrent use of medications, etc., were noted. Results: Patients with IBS-D were 119 (51% with a mean age of 35 ± 13 years, while those with CNSD were 115 (49% with mean age 36 ± 15 years. Patients in both IBS-D and CNSD were comparable in gender, with male 87 (74% and female 77 (64%. SIBO was documented by lactose H 2 BT in 32/234 (14% cases. It was positive in 22/119 (19% cases with IBS-D, while 10/115 (9% cases had CNSD (P = 0.03. LI was positive in 43/234 (18% cases. Of these, 25/119 (21% cases had IBS-D and 18/115 (16% cases had CNSD (P = 0.29. Conclusion: SIBO was seen in a significant number of our patients with IBS-D. There was no significant age or gender difference in patients with or without SIBO.

  19. Fructose and/or Sorbitol Intolerance in a Subgroup of Lactose Intolerant Patients

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    SR Mishkin

    1994-01-01

    Full Text Available The diagnosis and treatment of lactose intolerance often does not resolve all the symptoms of postcibal bloating and flatulence. Included in this study were 104 lactose intolerant patients (71 female, 33 male who complained of residual postcibal discomfort in spite of adherence to and benefit from appropriate measures for their documented lactose intolerance (at least 20 ppm H2 after 25 g lactose as well as appropriate symptomatic discomfort. Clinical characteristics common to this group included: symptomatic diarrhea (12.5%, history of foreign travel (5.8%, endoscopic and pathological evidence of gastritis and helicobacter infection (19.2 and 8.7%, respectively, nonspecific abnormalities of small bowel follow-through (15.4%, Crohn’s disease (8.7% and colonic cliverticulosis (14.4%. Intolerance co fructose (at least 10 ppm H2 after 25 g fructose plus appropriate symptoms or sorbitol (at least 10 ppm H2 after 5 g sorbitol plus appropriate symptoms was documented in 17.3 and 18.3%, respectively. Intolerance to both fructose and sorbicol (administered as separate challenges, more than twice as common as intolerance to either one alone, occurred in 41.4% and was independent of sex. In conclusion, additional carbohydrate intolerances contribute to postcibal discomfort in more than 75% of lactose intolerant patients who remain symptomatic in spite of adherence to appropriate measures for this condition. While 62% of all patients had benefited significantly (greater than 50% from appropriate dietary measures and enzyme replacement for lactose intolerance, only 40% of those who were also fructose intolerant and 47% who were sorbitol intolerant benefited (greater than 50% from appropriate dietary measures (no enzyme replacement yet available for intolerance to these sugars.

  20. Seasonal structure and dynamics of sarcosaprophagous fauna on pig carrion in a rural area of Cordoba (Argentina): their importance in forensic science.

    Science.gov (United States)

    Battán Horenstein, Moira; Rosso, Beatriz; García, M Dolores

    2012-04-10

    Four experiments, one in each season, were carried out during 2004 in a rural area of Córdoba, central Argentina. Two pigs (Sus scrofa L.), weighing approximately 8 kg each, were used in each of the four experiments. The animals were killed by a sharp blow to the head and immediately placed in an appropriate arthropod trap. One pig was placed in the shade and the other under direct sunlight. This research was conducted to determine the seasonal structure and dynamics of arthropods that constitute the sarcosaprophagous community in a given area of the central region of Argentina. The decomposition process was divided into five stages: fresh, bloated, decay, advanced decay and dry. The duration of each stage varied in different seasons, showing that the temperature and humidity are the most important variables that influence this process. A total of 51,500 adults and 36,909 immature were collected. More than 80% of the specimens collected belong to Insecta, and within this, Diptera were the most abundant order. The flies were mainly represented by adults and immature of the following species: Chrysomya albiceps (Wiedemann) (Calliphoridae), Musca domestica Linnaeus (Muscidae) and Fannia femoralis (Stein) (Fanniidae). Coleoptera were mainly represented by adults and immature of the species Creophilus maxillosus (Linnaeus) (Staphylinidae) and Dermestes maculatus (Geer) (Dermestidae). More than 50% of hymenopteran fauna collected belong to Formicidae. The trophic levels associated with the decomposition of the remains included five categories: necrophagous, parasites and predators of the necrophagous species, omnivores, opportunists and adventives. During faunal succession a strong dominance of the necrophagous species of the family Calliphoridae and Muscidae was observed, mainly during the early stages of decay process in all seasons.

  1. Clinical observation on treating postoperative abdominal distention by moxibustion%艾灸对术后腹胀的疗效观察

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    李俏梅; 高淑红; 王芳

    2014-01-01

    目的:观察艾灸疗法对术后腹胀的疗效。方法:将100例腹部手术后患者随机进行分组,对照组于术后6h协助床上适当活动,并协助早期下床待肛门自然排气。观察组在此基础上,采用术后6h行艾灸中脘、神阙、足三里三穴,观察出现腹胀减轻及肛门首次排气的时间。结果:观察组术后腹胀减轻及首次肛门排气时间均明显提前于对照组。结论:艾灸中脘、神阙、足三里三穴能有效促进腹部术后肠蠕动,减轻腹胀,且使肛门排气时间提前。%Objective: To observe the effects of moxibustion on postoperative abdominal distention. Methods:100 patients were grouped immediately after abdominal surgery, the control group was assisted to do some appropriate activities in bed after surgery and was helped to get out of bed for natural exhausting. Based on this therapy, the observation was acupuncture at Zhongwan, Shenque point and Zusanli point, reducing bloating and anal exhausting time were recorded. Results:The mitigation of postoperative abdominal distention and first anal exhausting time in observation group were significantly better than that in control group. Conclusion:Acupuncture at Zhongwan, Shenque point, Zusanli point can effectively promote postoperative abdominal peristalsis, reduce abdominal distention and advance the anus exhausting time.

  2. THE PREVALENCE OF CELIAC DISEASE AMONG PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

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    Sedat IŞIKAY

    2015-03-01

    Full Text Available Background Familial Mediterranean Fever and celiac disease are both related to auto-inflammation and/or auto-immunity and they share some common clinical features such as abdominal pain, diarrhea, bloating and flatulence. Objectives We aimed to determine the association of these two diseases, if present. Methods Totally 112 patients diagnosed with Familial Mediterranean Fever and 32 cases as healthy control were included in the study. All participants were examined for the evidence of celiac disease, with serum tissue transglutaminase IgA levels (tTG IgA. Results Totally 144 cases, 112 with Familial Mediterranean Fever and 32 healthy control cases were included in the study. tTG IgA positivity was determined in three cases with Familial Mediterranean Fever and in one case in control group. In that aspect there was no significant difference regarding the tTG IgA positivity between groups (P=0.81. Duodenum biopsy was performed to the tTG IgA positive cases and revealed Marsh Type 3b in two Familial Mediterranean Fever cases and Marsh Type 3c in the other one while the biopsy results were of the only tTG IgA positive case in control group was Marsh Type 3b. In HLA evaluation of the celiac cases; HLA DQ2 was present in two celiac cases of the Familial Mediterranean Fever group and in the only celiac case of the control group while HLA DQ8 was present in one celiac case of the Familial Mediterranean Fever group. Conclusions We did not determine an association of Familial Mediterranean Fever with celiac disease. Larger studies with subgroup analysis are warranted to determine the relationship of these two diseases.

  3. The Epidemiology of Functional Gastrointestinal Disorders in Mexico: A Population-Based Study

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    Aurelio López-Colombo

    2012-01-01

    Full Text Available Aims. The frequency of functional gastrointestinal disorders (FGIDs in the general population of Mexico is unknown. Methods. To determine the prevalence of FGIDs, associated depression, and health care utilization, a population-based sampling strategy was used to select 500 households in the State of Tlaxcala, in central Mexico. Household interviews were conducted by two trained physicians using the Rome II Modular Questionnaire, a health-care and medication used questionnaire and the CES-D depression scale. Results. The most common FGIDs were IBS: 16.0% (95% CI: 12.9–19.5; functional bloating: 10.8% (8.2–13.9; unspecified functional bowel disorder: 10.6% (8.0–13.6; and functional constipation (FC: 7.4% (5.3–10.1. Uninvestigated heartburn was common: 19.6% (16.2–23.4. All FGIDs were equally prevalent among both genders, except for IBS (P=0.001, IBS-C (P<0.001, IBS-A/M (P=0.049, and FC (P=0.039 which were more frequent in women. Subjects with FGIDs reported higher frequencies of medical visits: 34.6 versus 16.8%; use of medications: 40.7 versus 21.6%; (both P<0.001; and reported depression: 26.7 versus 6.7%, (P<0.001. Conclusion. In this first population-based study of FGIDs in Mexico, heartburn, IBS, functional distension, and FC were common. Only IBS, IBS-C, IBS-A/M, and FC were more frequent in women. Finally, FGIDs in Mexico had an increased burden of health care utilization and depression.

  4. The epidemiology of functional gastrointestinal disorders in Mexico: a population-based study.

    Science.gov (United States)

    López-Colombo, Aurelio; Morgan, Douglas; Bravo-González, Dalia; Montiel-Jarquín, Alvaro; Méndez-Martínez, Socorro; Schmulson, Max

    2012-01-01

    Aims. The frequency of functional gastrointestinal disorders (FGIDs) in the general population of Mexico is unknown. Methods. To determine the prevalence of FGIDs, associated depression, and health care utilization, a population-based sampling strategy was used to select 500 households in the State of Tlaxcala, in central Mexico. Household interviews were conducted by two trained physicians using the Rome II Modular Questionnaire, a health-care and medication used questionnaire and the CES-D depression scale. Results. The most common FGIDs were IBS: 16.0% (95% CI: 12.9-19.5); functional bloating: 10.8% (8.2-13.9); unspecified functional bowel disorder: 10.6% (8.0-13.6); and functional constipation (FC): 7.4% (5.3-10.1). Uninvestigated heartburn was common: 19.6% (16.2-23.4). All FGIDs were equally prevalent among both genders, except for IBS (P = 0.001), IBS-C (P < 0.001), IBS-A/M (P = 0.049), and FC (P = 0.039) which were more frequent in women. Subjects with FGIDs reported higher frequencies of medical visits: 34.6 versus 16.8%; use of medications: 40.7 versus 21.6%; (both P < 0.001); and reported depression: 26.7 versus 6.7%, (P < 0.001). Conclusion. In this first population-based study of FGIDs in Mexico, heartburn, IBS, functional distension, and FC were common. Only IBS, IBS-C, IBS-A/M, and FC were more frequent in women. Finally, FGIDs in Mexico had an increased burden of health care utilization and depression.

  5. Establishment of risk model for pancreatic cancer in Chinese Han population

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    Xing-Hua Lu; Li Wang; Hui Li; Jia-Ming Qian; Rui-Xue Deng; Lu Zhou

    2006-01-01

    AIM: To investigate risk factors for pancreatic cancer and establish a risk model for Han population.METHODS: This population-based case-control study was carried out from January 2002 to April 2004. One hundred and nineteen pancreatic cancer patients and 238 healthy people completed the questionnaire which was used for risk factor analysis. Logistic regression analysis was used to calculate odds ratio (ORs), 95%confidence intervals (Cis) and β value, which were further used to establish the risk model.RESULTS: According to the study, people who have smoked more than 17 pack-years had a higher risk to develop pancreatic cancer compared to non-smokers or light smokers (not more than 17 pack-years) (OR 1.98;95% CI 1.11-3.49, P=0.017). More importantly, heavy smokers in men had increased risk for developing pancreatic cancer (OR 2.11; 95%CI 1.18-3.78, P=0.012)than women. Heavy alcohol drinkers (>20 cup-years)had increased risk for pancreatic cancer (OR 3.68;95%CI 1.60-8.44). Daily diet with high meat intak was also linked to pancreatic cancer. Moreover, 18.5% of the pancreatic cancer patients had diabetes mellitus compared to the control group of 5.8% (P= 0.0003). Typical symptoms of pancreatic cancer were anorexia, upper abdominal pain, bloating, jaundice and weight loss. Each risk factor was assigned a value to represent its impor tance associated with pancreatic cancer. Subsequently by adding all the points together, a risk scoring model was established with a value higher than 45 as being at risk to develop pancreatic cancer.CONCLUSION: Smoking, drinking, high meat diet and diabetes are major risk factors for pancreatic cancer. A risk model for pancreatic cancer in Chinese Hah population has been established with an 88.9% sensitivity and a 97.6% specificity.

  6. Clinical Practice Guideline: Irritable bowel syndrome with constipation and functional constipation in the adult.

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    Mearin, Fermín; Ciriza, Constanza; Mínguez, Miguel; Rey, Enrique; Mascort, Juan José; Peña, Enrique; Cañones, Pedro; Júdez, Javier

    2016-06-01

    In this Clinical Practice Guideline we discuss the diagnostic and therapeutic approach of adult patients with constipation and abdominal complaints at the confluence of the irritable bowel syndrome spectrum and functional constipation. Both conditions are included among the functional bowel disorders, and have a significant personal, healthcare, and social impact, affecting the quality of life of the patients who suffer from them. The first one is the irritable bowel syndrome subtype, where constipation represents the predominant complaint, in association with recurrent abdominal pain, bloating, and abdominal distension. Constipation is characterized by difficulties with or low frequency of bowel movements, often accompanied by straining during defecation or a feeling of incomplete evacuation. Most cases have no underlying medical cause, and are therefore considered as a functional bowel disorder. There are many clinical and pathophysiological similarities between both disorders, and both respond similarly to commonly used drugs, their primary difference being the presence or absence of pain, albeit not in an "all or nothing" manner. Severity depends not only upon bowel symptom intensity but also upon other biopsychosocial factors (association of gastrointestinal and extraintestinal symptoms, grade of involvement, and perception and behavior variants). Functional bowel disorders are diagnosed using the Rome criteria. This Clinical Practice Guideline has been made consistent with the Rome IV criteria, which were published late in May 2016, and discuss alarm criteria, diagnostic tests, and referral criteria between Primary Care and gastroenterology settings. Furthermore, all the available treatment options (exercise, fluid ingestion, diet with soluble fiber-rich foods, fiber supplementation, other dietary components, osmotic or stimulating laxatives, probiotics, antibiotics, spasmolytics, peppermint essence, prucalopride, linaclotide, lubiprostone, biofeedback

  7. Adrenal incidentalomas: A collection of six interesting cases and brief review of literature

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    Roopal Panchani

    2012-01-01

    Full Text Available Introduction: Adrenal incidentalomas (AI are detected in approximately 4-7% of patients in imaging studies. Majority are benign, but careful evaluation is warranted to rule out carcinoma and functional adenomas. Aim: The purpose of presenting these cases is to highlight the approach to management of AI in terms of diagnosis, follow-up, and treatment. Materials and Methods: Seven patients presenting in the endocrine clinic with AI were evaluated for their presenting clinical features and investigated. Results: Case 1 was a 49-year-old female, with adrenal androgen secreting adrenocortical carcinoma with amenorrhoea which was mistaken as menopause. She had minimal hirsutism, which was mistaken as postmenopausal hirsutism. Case 2 was a 39-year-old male, presenting with hyperglycemia found to have Conns′ syndrome with aldosterone producing adenoma on routine ultrasound. Case 3 was a 32-year-old male, presenting with gastritis and bloating, where ultrasound showed bilateral large adrenal masses revealed as diffuse large B cell lymphoma on biopsy. Case 4 was a 21-year-old boy, who had pheochromocytoma misdiagnosed as benign intracranial hypertension (HTN. Case 5 was a 59-year-old hypertensive male, presenting with fever had pheochromocytoma with catecholamine excess, producing fever. Case 6 was isolated adrenal tuberculosis who presented with chronic diarrhea. Conclusion: AI are common, though prevalence varies depending on the reason for scanning, the characteristics of the population studied, and the radiological techniques used. Most are non-secreting cortical adenomas. AI should be evaluated both biochemically and radiologically. When a hormonal disorder is suspected clinically, targeted, diagnostic testing for autonomous cortisol secretion, pheochromocytoma, and hyperaldosteronism is indicated.

  8. Levonorgestrel-releasing intrauterine system (Mirena in compare to medroxyprogesterone acetate as a therapy for endometrial hyperplasia

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    Fariba Behnamfar

    2014-01-01

    Full Text Available Background: This study was designed to evaluate the comparison of insertion of levonorgestrel (LNG-releasing intrauterine system versus oral medroxyprogesterone acetate on endometrial hyperplasia in a randomized controlled trial. Materials and Methods: A total of 60 women with the initial histopathological diagnosis of endometrial hyperplasia in two groups received LNG or medroxyprogesterone (10 mg/d orally for 12 days a month for 3 months. Endometrial biopsy was obtained for all patients after 3 months of treatment. Response to treatment was defined based on the histopathology of the post treatment pipelle endometrial specimens in three categories of resolution, persistence and progression. Results: Treatment response rate in patients in the LNG group was 89.3% (25 of 28 patients, versus 70.4% (19 of 27 patients in patients in the medroxyprogesterone group. The rate of persistence was 10.7% (3 of 28 patients and 22.2% (6 of 27 patients in LNG and medroxyprogesterone groups respectively. No progression of endometrial hyperplasia observed in any of the patients in LNG group, but progression of endometrial hyperplasia was observed in 7.4% (2 of 27 patients in the medroxyprogesterone group. There was no statistically significant difference between groups regarding the response to treatment (P = 0.15. Side effects such as bloating, weight gain, fatigue and hair loss were comparable between the groups (P > 0.05. Hirsutism was significantly more in the medroxyprogesterone group than LNG group (P = 0.013. Conclusion: Results showed that the use of LNG for treating endometrial hyperplasia for 3 months was associated with high-treatment response rate and the low proportion of patients with progression compared to the use of medroxyprogesterone.

  9. Rising Food Insecurity: Dimensions in Farm Households

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    Okezie C. Austin

    2011-01-01

    Full Text Available Problem statement: Nigeria runs the risk of slowing further progress toward the achievement of MDG-1 to eradicate extreme hunger and poverty; the fourth goal, to reduce child mortality since over 30% of child deaths are attributable to malnutrition and the fifth goal relating to reduction in maternal mortality. This study evaluated the manifestation of food insecurity in households in Abia State, Nigeria. Approach: Systematic sampling was adopted in selecting households from the three geopolitical zones in the state. Primary and secondary data were used in the study. Data collection involved the use of structured questionnaires. Food intake, height and weight measures of children were taken Data analysis in involved the use of qualitative and quantitative methods. Results: Domestic food production is increasing but demand remained above production. The shortfall along with food import is on the increase. The composite consumer price index for food has continued to rise over the years. Logistic results show that income significantly reduced exposure to food insecurity while household size was an important determinant of food security. Children were more exposed to the incidence of growth retardation and stunting with increasing household size. Birth order increases the incidence of stunting. As more children come into the family there is increasing marginalization of the subsequent ones. Conclusion: Food insecurity is a developmental challenge in Nigeria. The country is characterized by high food imports and declining productivity of agriculture. Malnutrition is widespread especially among children in rural Nigeria. The study recommends family planning education to stern the over bloated population.

  10. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial

    Science.gov (United States)

    Yoon, Hyuk; Park, Young Soo; Lee, Dong Ho; Seo, Jae-Gu; Shin, Cheol Min; Kim,, Nayoung

    2015-01-01

    We assessed the effect of multi-species probiotic mixture on the changes in fecal microbiota and irritable bowel syndrome (IBS) symptoms. Eighty-one IBS patients were randomly assigned to receive either probiotic mixture (n = 39; containing Lactobacillus acidophilus, L. rhamnosus, Bifidobacterium breve, B. actis, B. longum, and Streptococcus thermophilus) or placebo (n = 42) for 4 weeks. A questionnaire regarding general symptom relief was administered. The change in total symptom scores (sum of 10 IBS symptoms) and subtotal scores in 4 domains (pain, constipation, diarrhea, and bloating/gas) were evaluated. The change in fecal flora was determined by quantitative real-time PCR. The concentration of probiotic strains significantly increased after ingestion in probiotics group (B. bifidum, p = 0.043; B. lactis, p<0.001; L. acidophilus, p = 0.016; L. rhamnosus, p<0.001). The proportion of patients with adequate symptom relief was higher in probiotics group than in placebo group (74.4% vs 61.9%, p = 0.230). The decrease in total symptom score over time was not significantly different between the groups (p = 0.703). Among subtotal scores of 4 IBS symptom domains, the time effect was significantly different for diarrhea-symptom score between the groups (p = 0.017). A 4-week administration of multi-species probiotic mixture significantly increased the fecal concentration of most probiotic strains and improved diarrhea-symptom scores in IBS patients. PMID:26388670

  11. Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention

    Institute of Scientific and Technical Information of China (English)

    Guo-Shuang Feng; Harry HX Xia; Ji-You Li; Shiu Kum Lam; Wei-Cheng You; Jun-Ling Ma; Benjamin CY Wong; Lian Zhang; Wei-Dong Liu; Kai-Feng Pan; Lin Shen; Xiao-Dong Zhang; Jie Li

    2008-01-01

    AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind,placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted.RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who Received: celecoxib and 17 of 473 (3.31%) patients who Received placebo,respectively (odds ratio = 1.13, 95% CI = 0.58-2.19).Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo,respectively.Compared with those who received placebo,patients who received celecoxib had no significant increase in occurrence of Cvevents (hazard ratio = 0.84,95% CI =0.23-3.15).Among the adverse events acquired by interview survey,only the frequency of bloating was significantly higher in patients treated with celecoxib than in those treated with placebo.CONCLUSION:Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events.

  12. Self-Reported Prevalence of Symptomatic Adverse Reactions to Gluten and Adherence to Gluten-Free Diet in an Adult Mexican Population.

    Science.gov (United States)

    Ontiveros, Noe; López-Gallardo, Jesús A; Vergara-Jiménez, Marcela J; Cabrera-Chávez, Francisco

    2015-07-21

    The prevalence of symptomatic adverse reactions to gluten and adherence to gluten-free diet in Latin American countries is unknown. These measurements are strongly linked to gluten-related disorders. This work aimed to estimate the prevalence of adverse reactions to oral gluten and the adherence to gluten-free diet in the adult Mexican population. To reach this aim, a self-administered questionnaire was designed and tested for clarity/comprehension and reproducibility. Then, a self-administered questionnaire-based cross-sectional study was conducted in the Mexican population. The estimated prevalence rates were (95% CI): 11.9% (9.9-13.5) and 7.8 (6.4-9.4) for adverse and recurrent adverse reactions to gluten respectively; adherence to gluten-free diet 3.7% (2.7-4.8), wheat allergy 0.72% (0.38-1.37); celiac disease 0.08% (0.01-0.45), and NCGS 0.97% (0.55-1.68). Estimated pooled prevalence of self-reported physician-diagnosis of gluten-related disorders was 0.88% (0.49-1.5), and 93.3% respondents reported adherence to gluten-free diet without a physician-diagnosis of gluten-related disorders. Symptom comparisons between those who reported recurrent adverse reactions to gluten and other foods showed statistically significant differences for bloating, constipation, and tiredness (p Gluten-related disorders may be underdiagnosed in the Mexican population and most people adhering to a gluten-free diet are doing it without proper diagnostic work-up of these disorders, and probably without medical/dietician advice.

  13. WASP-42 b and WASP-49 b: two new transiting sub-Jupiters

    Science.gov (United States)

    Lendl, M.; Anderson, D. R.; Collier-Cameron, A.; Doyle, A. P.; Gillon, M.; Hellier, C.; Jehin, E.; Lister, T. A.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Smalley, B.; Ségransan, D.; Smith, A. M. S.; Triaud, A. H. M. J.; Udry, S.; West, R. G.; Wheatley, P. J.

    2012-08-01

    We report the discovery of two new transiting planets from the WASP survey. WASP-42 b is a 0.500 ± 0.035 MJ planet orbiting a K1 star at a separation of 0.0548 ± 0.0017 AU with a period of 4.9816872 ± 7.3 × 10-6 days. The radius of WASP-42 b is 1.080 ± 0.057 RJ while its equilibrium temperature is Teq = 995 ± 34 K. We detect some evidence for a small but non-zero eccentricity of e = 0.060 ± 0.013. WASP-49 b is a 0.378 ± 0.027 MJ planet around an old G6 star. It has a period of 2.7817387 ± 5.6 × 10-6 days and a separation of 0.0379 ± 0.0011 AU. This planet is slightly bloated, having a radius of 1.115 ± 0.047 RJ and an equilibrium temperature of Teq = 1369 ± 39 K. Both planets have been followed up photometrically, and in total we have obtained 5 full and one partial transit light curves of WASP-42 and 4 full and one partial light curves of WASP-49 using the Euler-Swiss, TRAPPIST and Faulkes South telescopes. Based on photometric observations made with WASP-South, EulerCam on the Euler-Swiss telescope, the Belgian TRAPPIST telescope, the Faulkes South Telescope and spectroscopic observations obtained with CORALIE on the Euler-Swiss telescope and HARPS on the ESO 3.6 m telescope (Prog. ID: 087.C-0649).The photometric time series and radial velocity data in this work are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/544/A72

  14. Nutritional Education Needs in Relation to Ramadan Fasting and Its Complications in Tehran, Iran

    Science.gov (United States)

    Shadman, Zhaleh; Akhoundan, Mahdieh; Poorsoltan, Nooshin; Khoshniat Nikoo, Mohsen; Larijani, Bagher; Akhgar Zhand, Camelia; Soleymanzadeh, Mozhdeh; Alsadat Seyed Rohani, Zahra; Jamshidi, Zahra

    2016-01-01

    Background Ramadan fasting is associated with some lifestyle changes. A lack of nutritional needs knowledge or the improper performance of fasting, particularly in relation to time, type and amount of food intake, can cause disorders such as indigestion, bloating, constipation, headaches and other clinical problems. Objectives To investigate the general knowledge regarding dietary factors associated with Ramadan fasting and its related complications. Patients and Methods This prospective, non-interventional, observational study was conducted from April to July, 2012 to coincide with the month before and the month of Ramadan. The initial participants were 600 fasting and 588 non-fasting people (aged 18 - 65 years, BMI 18.5 - 40 kg/m2) chosen by random cluster sampling in Tehran, Iran. A questionnaire of Ramadan fasting nutritional knowledge was developed and validated in a pilot study. The Likert scale was used two weeks before Ramadan and during the third and fourth weeks of Ramadan to estimate Ramadan-related complications. Seven-day, 24 - hour food recalls were used to assess food intakes. Results The lowest level of general knowledge was identified in the context of foods associated with hunger (22.1%) and hypoglycemia (24.8%) and the highest level of general knowledge was identified in reference to unsuitable foods for Sahar (91.4%). During Ramadan, all attributed complications increased in fasting subjects (P diet were associated with some gastrointestinal and sleep complications (P diet to prevent Ramadan-related complications, practical training in regard to the amounts of nutrients associated with Ramadan-related complications is both necessary and recommended.

  15. Symptoms of depression and quality of life in functional dyspepsia patients

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    Muhammad Eko Cahyanto Neneng Ratnasari Agus Siswanto

    2014-08-01

    Full Text Available Dyspepsia is a common disorder characterized by heartburn, nausea, vomiting, bloating, feelingof fullness or early satiety, and belching. Functional dyspepsia (FD or non-ulcer dyspepsia is asyndrome without any physical or endoscopic abnormalities underlying these symptoms. Theimpacts of FD on psychological disturbances and quality of life in patients have been postulated.However, it has not much been a concern. This study was conducted to evaluate the relationshipbetween symptoms of depression and quality of life in patients with FD. This was an observationalstudy with cross-sectional design involving 30 patients. The symptoms of depression weremeasured by beck depression inventory (BDI and the quality of life of patients were measuredby SF-36. The results showed that FD were more suffered consecutively by female patients(66.7%, age over 45 years (53.4%, housewives (56.6%, educated graduates (56.6% andmarried (90.0%. Moreover, patients who experienced symptoms of clinical depression withlow, moderate and severe levels were 16.3%, 33.3% dan 10.0%, respectively. A significantcorrelation between depressive symptoms and the overall of patients quality of life was observed(r = 0.481; p<0.05. Furthermore analysis showed that among eight domains of health in SF-36analyzed, a negative significant correlation was observed between the depressive symptoms andthe three domains of health i.e. general physical function, limitation of motion caused byphysical problems, and vitality. In conclusion, there is a negative correlation between depressivesymptoms and quality of life in patients with FD.

  16. PREMENSTRUAL SYNDROME IN YOUNG GIRLS - ACADEMIC LOSS/WORK PRODUCTIVITY

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    Vijayalakshmi

    2015-10-01

    Full Text Available INTRODUCTION: Premenstrual syndrome is a common problem in young girls which adversely affects their educational performance and emotional well - being. PMS is associated with reductions in health - related quality of life and work productivity impairment regardless of the criteria used. We evaluated the loss the work productivity and functional impairment adolescent girls associated with premenstrual symptoms and dysphoric disorder (PMDD. METHODS: A total of 100 unmarried girls who had regular cycles for last 6 months, between the age group of 13 - 19 years, having dysmenorrhic symptoms and having a menstrual cycle length 0f 21 - 35 days were enrolled. Data was collected on Socio economic profile menstrual profile, PMS symptoms ACOG, DSM - IV (PMDD & Work productivity loss & Impairment. Symptoms were recorded. RESULTS: Physical symptoms, the highest % of symptoms are with Abdominal Bloating (95.81%; Breast Discomfort (94.72%; Acne (93.44%; Body ache (90.71%; Increased appetite (87.43%. Psychological symptoms - Angry (94.35% >Anxiety (92.71% >Irritability (91.44% >Feeling depressed (90.35% >Feeling Stress (85.97%. Behavioral S ymptoms: - Personality Change (85.6% >Abstinence from Work (80.5% >Violent Outburst (77.9% Work Productivity Loss and Functional I mpairment: - 27.1% have reported to have a loss of more than 2 days; 12% have reported to have loss of more than 5 days; 2% have reported to have a loss of more than 14 days. CONCLUSION: In the present study, 41% had academic/ work loss. 24% of PMS patients who missed more than 5 days per month with 50% reduction in work productivity and 2% missed more than 14 days per month with impairment in work/social activities/relationships.

  17. The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

    Science.gov (United States)

    Farzaei, Mohammad H; Bahramsoltani, Roodabeh; Abdollahi, Mohammad; Rahimi, Roja

    2016-01-01

    Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process that may occur within the peripheral or central nervous systems and plays a principal role in the etiology of IBS symptoms. The pharmacological studies on selective drugs based on targeting specific ligands can provide novel therapies for modulation of persistent visceral hyperalgesia. The current paper reviews the cellular and molecular mechanisms underlying therapeutic targeting for providing future drugs to protect or treat visceroperception and pain sensitization in IBS patients. There are a wide range of mediators and receptors participating in visceral pain perception amongst which substances targeting afferent receptors are attractive sources of novel drugs. Novel therapeutic targets for the management of VH include compounds which alter gut-brain pathways and local neuroimmune pathways. Molecular mediators and receptors participating in pain perception and visceroperception include histamine-1 receptors, serotonin (5-hydrodytryptamine) receptors, transient receptor potential vanilloid type I, tachykinins ligands, opioid receptors, voltage-gated channels, tyrosine receptor kinase receptors, protease-activated receptors, adrenergic system ligands, cannabinoid receptors, sex hormones, and glutamate receptors which are discussed in the current review. Moreover, several plant-derived natural compounds with potential to alleviate VH in IBS have been highlighted. VH has an important role in the pathology and severity of complications in IBS. Therefore, managing VH can remarkably modulate the symptoms of IBS. More preclinical and clinical investigations are needed to provide efficacious and targeted medicines for the management of VH. PMID:27431236

  18. Drospirenone/ethinyl estradiol.

    Science.gov (United States)

    Rapkin, Andrea J; Sorger, Shelley N; Winer, Sharon A

    2008-02-01

    Drospirenone 3 mg/ethinyl estradiol 20 microg (24/4) is a new unique oral contraceptive formulation that combines in a novel dosing regimen the lowest dosage of ethinyl estradiol commonly used today with drospirenone, an innovative progestin. Drospirenone is a compound closely resembling progesterone, but with the antimineralocorticoid and antiandrogenic properties of a related therapeutic agent, the diuretic, antihypertensive and androgen receptor antagonist, 17alpha-spironolactone. The prolongation of hormonally active pills in the monthly drospirenone/ethinyl estradiol cycle from 21 days to 24 days, followed by 4 days of inactive pills, is an interesting variant of the recently developed extended pill regimens (1). Recent contraceptive research has focused on improving side effect profiles and providing noncontraceptive health and lifestyle advantages. Many of these benefits are now supported with evidence-based medicine (2). Most available oral contraceptives improve cycle regularity, menstrual pain, excessive menstrual flow and acne. However, weight gain, bloating, food cravings, breast tenderness and mood alterations (especially irritability and depression and the complex of affective, behavioral and somatic symptoms of premenstrual syndrome [PMS] and the severe form of PMS, premenstrual dysphoric disorder [PMDD]) are not generally improved with the traditional oral contraceptive formulations (3). Drospirenone/ethinyl estradiol 24/4 is currently the only hormonally based contraceptive regimen with large, randomized, controlled trials demonstrating efficacy for PMDD. It has received U.S. Food and Drug Administration (FDA) indications not only for the prevention of pregnancy but also for PMDD and for moderate acne vulgaris in women who choose oral contraception for birth control (4, 5).

  19. Diets, equipment, and techniques for maintaining crawfish in the laboratory

    Science.gov (United States)

    Tarshis, I.B.; Avault, James W.

    1978-01-01

    One commercial and 4 laboratory prepared extruded, water-stable diets were fed 3 times a week in 1-g portions to juvenile male and female White River crawfish, Procambarus acutus acutus (Girard), for 10 weeks. The. binding material in the laboratory preparation was alginate (Kelgin), whereas that in the commercial preparation was starch. No statistically significant weight differences developed between the groups of crawfish at the end of the 10-week period; all 5 diets were found satisfactory for feeding and maintaining P. acutus acutus in the laboratory, and all test crawfish survived throughout the experimental period. Weight gains were highest in a diet containing 50.5% protein; intermediate in those fed a diet with 46.0% protein; and lowest in those fed diets with 31.7 or 36.3% protein. Crawfish fed the commercial preparation of one of the 46.0% protein diets showed a slightly but not significantly higher weight gain than those fed the laboratory preparation of the diet. In an evaluation of the water stability of 5 commercially prepared animal chow diets and the commercial extruded diet, 2 of the commercial diets disintegrated after one hour exposure in water and the other 3 became bloated after one hour and remained on the surface throughout the 24-hour test. The commercial extruded diet maintained its water stability for the full 24 hours. The commercial preparation of the 46.0% protein diet was successfully used under laboratory conditions for feeding and maintaining the following crawfishes: Cambarellus shufeldtii (Faxon), Cambarus acuminatus Faxon, Orconectes limosus (Rafinesque), O. virilis (Hagen), Procambarus clarkii (Girard), and P. spiculifer (Le conte). In longevity experiments Cambarus diogenes diogenes Girard and Procambarus hinei (Ortmann) now have survived for 8 months on this diet in the laboratory.

  20. Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: Effects of gender, age, and body mass index

    Directory of Open Access Journals (Sweden)

    Luigi Russo

    2015-01-01

    Full Text Available Background/Aims: Partially hydrolyzed guar gum (PHGG relieves symptoms in constipation-predominant irritable bowel syndrome (IBS and may have prebiotic properties. However, the correlation between the effectiveness of PHGG and patient characteristics has not been examined. We aimed to investigate the effect of PHGG in symptom relief on constipation-predominant IBS according to gender, age, and body mass index (BMI. Patients and Methods: Sixty-eight patients with IBS entered a 2-week run-in period, followed by a 4-week study period with PHGG. Patients completed a daily questionnaire to assess the presence of abdominal pain/discomfort, swelling, and the sensation of incomplete evacuation. The number of evacuations/day, the daily need for laxatives/enemas and stool consistency-form were also evaluated. All patients also underwent a colonic transit time (CTT evaluation. Results: PHGG administration was associated with a significant improvement in symptom scores, use of laxatives/enemas, stool form/consistency and CTT. At the end of the study period and compared with baseline, the number of evacuations improved in women, patients aged ≥ 45 years and those with BMI ≥ 25 (P < 0.05 for all comparisons; abdominal bloating improved in males (P < 0.05, patients < 45 years (P < 0.01 and those with BMI < 25 (P < 0.05. A decrease in the number of perceived incomplete evacuations/day was reported in patients with a BMI ≥ 25 (P < 0.05. Reductions in laxative/enema use were recorded in females (P < 0.05, patients < 45 years (P < 0.01, and patients with BMI < 25 (P < 0.05. Conclusions: Gender, age, and BMI seem to influence the effect of PHGG supplementation in constipated IBS patients. Further studies are needed to clarify the interaction of such parameters with a fiber-enriched diet.

  1. A randomised controlled trial on hypnotherapy for irritable bowel syndrome: design and methodological challenges (the IMAGINE study

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    Flik Carla E

    2011-12-01

    Full Text Available Abstract Background Irritable Bowel Syndrome (IBS is a common gastro-intestinal disorder in primary and secondary care, characterised by abdominal pain, discomfort, altered bowel habits and/or symptoms of bloating and distension. In general the efficacy of drug therapies is poor. Hypnotherapy as well as Cognitive Behaviour Therapy and short Psychodynamic Therapy appear to be useful options for patients with refractory IBS in secondary care and are cost-effective, but the evidence is still limited. The IMAGINE-study is therefore designed to assess the overall benefit of hypnotherapy in IBS as well as comparing the efficacy of individual versus group hypnotherapy in treating this condition. Methods/Design The design is a randomised placebo-controlled trial. The study group consists of 354 primary care and secondary care patients (aged 18-65 with IBS (Rome-III criteria. Patients will be randomly allocated to either 6 sessions of individual hypnotherapy, 6 sessions of group hypnotherapy or 6 sessions of educational supportive therapy in a group (placebo, with a follow up of 9 months post treatment for all patients. Ten hospitals and four primary care psychological practices in different parts of The Netherlands will collaborate in this study. The primary efficacy parameter is the responder rate for adequate relief of IBS symptoms. Secondary efficacy parameters are changes in the IBS symptom severity, quality of life, cognitions, psychological complaints, self-efficacy as well as direct and indirect costs of the condition. Hypnotherapy is expected to be more effective than the control therapy, and group hypnotherapy is expected not to be inferior to individual hypnotherapy. Discussion If hypnotherapy is effective and if there is no difference in efficacy between individual and group hypnotherapy, this group form of treatment could be offered to more IBS patients, at lower costs. Trial registration number ISRCTN: ISRCTN22888906

  2. Effect of dietary tannin source feeds on Ruminal fermentation and production of cattle; a review.

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    Addisu Sh.

    2016-02-01

    Full Text Available Generally, tannins are widely distributed throughout the plant kingdom, especially among trees, shrubs and herbaceous leguminous plants. Tannins are naturally occurring polyphenols with different molecular weights and complexity that are synthesized during the secondary metabolism of plants. Tannins might bind to macromolecules (proteins, structural carbohydrates and starch and decrease their availability to digestion. Tannins based on their chemical structure and properties divided into two groups, hydrolyzable tannins (HT and Condensed tannins (CT, proanthocyanidins. Tannins are polyphenols, which directly or indirectly affect intake and digestion. They are the primary source of astringency in plants, which results from binding to proteins, forming soluble or insoluble complexes. The nature of the interaction is greatly dependent on the structure of the polyphenols and the proteins involved. Relatively low concentration of tannins (0.5% of DM intake is sufficient to destabilize the bloat proteins while high concentration (2-4% of DM intake is needed for improvement of protein utilization. High concentration (> 5% of dry weight reduces feed intake and feed conversion efficiency. Tannins containing forages will be important for small ruminants to control of gastrointestinal parasites. Animals fed condensed tannin had lower dressing percent than controlled one; with dressing percent being intermediate for animals fed hydrolysable tannin. Neither tannin source affected the animal’s consumption of the diet or the animal’s growth. Additionally, the tannin sources did not affect the meat or by-product tissues, making tannin supplementation a viable option in finishing beef cattle. Therefore, tannin source feed will have its own advantages and disadvantages on animals’ performance.

  3. Reduced responses of submucous neurons from irritable bowel syndrome patients to a cocktail containing histamine, serotonin, TNFα and tryptase (IBS-cocktail

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    Daniela eOstertag

    2015-12-01

    Full Text Available Background & Aims:Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS. Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC.Methods:Activity of human submucous neurons in response to electrical nerve stimulation and local application of nicotine or a mixture of histamine, serotonin, tryptase and TNF-α (IBS-cocktail was recorded in biopsies from 17 HC and 35 IBS patients with the calcium-sensitive-dye Fluo-4 AM. The concentrations of the mediators resembeled those found in biopsy supernatants or blood. Neuronal activity in guinea-pig submucous neurons was studied with the voltage-sensitive-dye di-8-ANEPPS. Results:Activity in submucous ganglia in response to nicotine or electrical nerve stimulation was not different between HC and IBS patients (P=0.097 or P=0.448. However, the neuronal response after application of the IBS-cocktail was significantly decreased (P=0.039 independent of whether diarrhea (n=12, constipation (n=5 or bloating (n=5 was the predominant symptom. In agreement with this we found that responses of submucous ganglia conditioned by overnight incubation with IBS mucosal biopsy supernatant to spritz application of this supernatant was significantly reduced (P=0.019 when compared to incubation with HC supernatant.Conclusion:We demonstrated for the first time reduced neuronal responses in mucosal IBS biopsies to an IBS mediator cocktail. While excitability to classical stimuli of enteric neurons was comparable to HC, the activation by the IBS-cocktail was decreased. This was very likely due to desensitization to mediators constantly released by mucosal and immune cells in the gut wall of IBS patients.

  4. Application of Robotic Surgery in the treatment of endometriosis: View point of an Indian OBGYN fellow in USA

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    Krishna Kavita Ramavath

    2015-02-01

    Full Text Available Background: This article is an observational experience of robotic surgery in USA by an Indian Obgyn fellow. Primary objective is to analyze retrospectively peri operative outcomes in stage 2 and 3 Endometriosis treated with robot assisted laparoscopy. Secondary objective is to report an Indian Obgyn, Physician observer fellows experience in USA with Robotic surgery. Methods: 29 women underwent robotic surgery at in the department of gynecology at Doctor's hospital, Baptist health, Miami. Pre-op time, console time, total operative time, blood loss, peri-operative complications noted. Results: Mean age is 42 +/- 8 years with BMI of 26.2 +/- 8 kg/m2. Eighteen patients (62% were age 40 and above. Twenty patients (69% presented with chronic pelvic pain. Dyspareunia in 16 (55.2%, bloating in five (17.2% and pelvic mass in thirteen (44.8% Unilateral pelvic mass in nine patients (31 % and bilateral in four patients (13.8%. CA 125 levels are elevated in nine patients (31% and significantly higher with endometriomas (76.1 +/- 49.2 U/ml. 38% underwent robot assisted laparoscopic hysterectomy and BSO. 14.8% underwent robot assisted laparoscopic hysterectomy with Robot (LSO/RSO. Mean operative time 64.7 min. Mean blood loss 40 ml. Conclusions: Robotic surgery is safe, with minimal blood loss and shorter hospital stay. Alike in the surgical techniques, though diverse in the work infrastructure and technology, East and West have common scenarios which can be tackled with exchange of training opportunities. This interchange of knowledge and skills will benefit patients with increased surgeon's efficiency. [Int J Reprod Contracept Obstet Gynecol 2015; 4(1.000: 202-209

  5. Eosinophilia in a patient with cyclical vomiting: a case report

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    Fitzgerald S Matthew

    2004-05-01

    Full Text Available Abstract Background Eosinophilic gastritis is related to eosinophilic gastroenteritis, varying only in regards to the extent of disease and small bowel involvement. Common symptoms reported are similar to our patient's including: abdominal pain, epigastric pain, anorexia, bloating, weight loss, diarrhea, ankle edema, dysphagia, melaena and postprandial nausea and vomiting. Microscopic features of eosinophilic infiltration usually occur in the lamina propria or submucosa with perivascular aggregates. The disease is likely mediated by eosinophils activated by various cytokines and chemokines. Therapy centers around the use of immunosuppressive agents and dietary therapy if food allergy is a factor. Case presentation The patient is a 31 year old Caucasian female with a past medical history significant for ulcerative colitis. She presented with recurrent bouts of vomiting, abdominal pain and chest discomfort of 11 months duration. The bouts of vomiting had been reoccurring every 7–10 days, with each episode lasting for 1–3 days. This was associated with extreme weakness and cachexia. Gastric biopsies revealed intense eosinophilic infiltration. The patient responded to glucocorticoids and azathioprine. The differential diagnosis and molecular pathogenesis of eosinophilic gastritis as well as the molecular effects of glucocorticoids in eosinophilic disorders are discussed. Conclusions The patient responded to a combination of glucocorticosteroids and azathioprine with decreased eosinophilia and symptoms. It is likely that eosinophil-active cytokines such as interleukin-3 (IL-3, granulocyte macrophage colony stimulating factor (GM-CSF and IL-5 play pivotal roles in this disease. Chemokines such as eotaxin may be involved in eosinophil recruitment. These mediators are downregulated or inhibited by the use of immunosuppressive medications.

  6. Intraerioneal Catheter Paracentesis with Fresh Plasma Treament Refractory Cirrhosis Ascites%腹腔置管放腹水加输血浆治疗顽固性肝硬化腹水

    Institute of Scientific and Technical Information of China (English)

    李广平; 张瑞椿

    2013-01-01

      目的观察腹腔置管放腹水联合新鲜血浆治疗顽固性肝硬化腹水疗效。方法53例顽固性肝硬化腹水患者,行腹腔置管放腹水,每次1000mL,隔日1次,同时输注新鲜血浆200mL,每日1次。结果患者精神食欲均明显好转,表现为尿量增加,腹围缩小明显,腹胀症状减轻或消失,肝肾功能各项检查指标较前好转,复查腹部B超提示腹水减少或消失。结论该方法具有较好的应用价值。%Objective Observe the effects of intraperitoneal catheter paracentesis with fresh plasma treatment refractory Cirrhosis Ascites;Methods 53 cases of patients with refractory Cirrhosis Ascites, carry out intraperitoneal catheter paracentesis, Each 1000mL, Every other day, While infusion of fresh plasma 200mL, Once a day. Result The Patients vitality and appetite Significantly improved, Performance increase for the amount of urine, the abdominal circumference narrow significantly, the bloating symptom relief or disappearance, examinations of liver and kidney function indicators better than before, Review abdomen B-type ultrasonic inspection point ascites reduce or disappear. Conclusion The method has a good application value.

  7. IRAS 19520+2759: a 105 L⊙ massive young stellar object driving a collimated outflow

    Science.gov (United States)

    Palau, Aina; Sánchez Contreras, C.; Sahai, R.; Sánchez-Monge, Á.; Rizzo, J. R.

    2013-01-01

    The theory of massive star formation currently suffers from a scarce observational base of massive young stellar objects to compare with. In this paper, we present interferometric 12CO (1-0), 13CO (1-0), C18O (1-0) and 2.6 mm continuum images of the infrared source IRAS 19520+2759 together with complementary single-dish observations of CS (1-0), obtained with the 34 m antenna DSS-54 at the Madrid Deep Space Communications Complex, as well as archive images at different wavelengths. As a result from our work, IRAS 19520+2759, with a controversial nature in the past, is firmly established as a massive young stellar object associated with a strong and compact millimetre source and driving a collimated outflow. In addition, a second fainter millimetre source is discovered about 4 arcsec to the south, which is also driving an outflow. Furthermore, the two millimetre sources are associated with C18O clumps elongated perpendicularly to the outflows, which may be related to rotating toroids. The masses of gas and dust of the millimetre sources are estimated to be around 100 and 50 M⊙. MM1, the dominant source at all wavelengths, with a total luminosity of (1-2) × 105 L⊙ at 9 kpc, is however not associated with 6 cm emission down to an rms noise level of 0.1 mJy. We propose that IRAS 19520+2759 could be an example of the recent theoretical prediction of `bloated' or `swollen' star, i.e. a massive young stellar object whose radius has increased due to effects of accretion at a high-mass accretion rate.

  8. Bovine immunoglobulin protein isolates for the nutritional management of enteropathy.

    Science.gov (United States)

    Petschow, Bryon W; Blikslager, Anthony T; Weaver, Eric M; Campbell, Joy M; Polo, Javier; Shaw, Audrey L; Burnett, Bruce P; Klein, Gerald L; Rhoads, J Marc

    2014-09-07

    The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus (HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome (IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function (e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management of enteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasma- or serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy.

  9. The Effect of Ginger (Zingiber officinalis and Artichoke (Cynara cardunculus Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Attilio Giacosa

    2015-01-01

    Full Text Available Objective. Functional dyspepsia (FD is a frequent clinical finding in western world. The aim of this study is to compare the efficacy of a ginger and artichoke supplementation versus placebo in the treatment of FD. Methods. A prospective multicentre, double blind, randomized, placebo controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was performed. Two capsules/day were supplied (before lunch and dinner to 126 FD patients (supplementation/placebo: 65/61. Results. After 14 days of treatment, only supplementation group (SG showed a significant amelioration (SG: αS=+1.195 MCA score units (u, P=0.017; placebo: αP=+0.347 u, P=0.513. The intercept (α resulted to be significantly higher in SG than in placebo (αS-αP=+0.848 u, P<0.001. At the end of the study, the advantage of SG versus placebo persists without variation (βS-βP=+0.077 u, P=0.542. In SG, a significant advantage is observed for nausea (βS-βP=-0.398 u, P<0.001, epigastric fullness (βS-βP=-0.241, P<0.001, epigastric pain (βS-βP=-0.173 u, P=0.002, and bloating (βS-βP=-0.167 u, P=0.017. Conclusions. The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease.

  10. Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages.

    Directory of Open Access Journals (Sweden)

    Jaimie Hoh Kam

    Full Text Available BACKGROUND: Amyloid beta (Aβ accumulates in the ageing central nervous system and is associated with a number of age-related diseases, including age-related macular degeneration (AMD in the eye. AMD is characterised by accumulation of extracellular deposits called drusen in which Aβ is a key constituent. Aβ activates the complement cascade and its deposition is associated with activated macrophages. So far, little is known about the quantitative measurements of Aβ accumulation and definitions of its relative sites of ocular deposition in the normal ageing mouse. METHODOLOGY/PRINCIPAL FINDINGS: We have traced Aβ accumulation quantitatively in the ageing mouse retina using immunohistochemistry and Western blot analysis. We reveal that it is not only deposited at Bruch's membrane and along blood vessels, but unexpectedly, it also coats photoreceptor outer segments. While Aβ is present at all sites of deposition from 3 months of age, it increases markedly from 6 months onward. Progressive accumulation of deposits on outer segments was confirmed with scanning electron microscopy, revealing age-related changes in their morphology. Such progress of accumulation of Aβ on photoreceptor outer segments with age was also confirmed in human retinae using immunohistochemistry. We also chart the macrophage response to increases in Aβ showing up-regulation in their numbers using both confocal laser imaging of the eye in vivo followed by in vitro immunostaining. With age macrophages become bloated with cellular debris including Aβ, however, their increasing numbers fail to stop Aβ accumulation. CONCLUSIONS: Increasing Aβ deposition in blood vessels and Bruch's membrane will impact upon retinal perfusion and clearance of cellular waste products from the outer retina, a region of very high metabolic activity. This accumulation of Aβ may contribute to the 30% reduction of photoreceptors found throughout life and the shortening of those that remain. The

  11. 未来网络休眠机制的研究%Research on sleep mechanism for future network

    Institute of Scientific and Technical Information of China (English)

    苏俊基; 杨龙祥; 朱乐恒

    2014-01-01

    Traditional Internet is so bloated that it produces a lot of problems, and the energy consumption is more and more outstanding. In order to slove these problems, it changes the future Internet architecture based on the principle of "clean-slate"rather than that of "patching the Internet". Some projects about future Internet architecture have been proposed at home and abroad , and put forward sleep mechanism to reduce energy consumption. This paper introduces some sleep mechanisms for future Internet architecture, simulate and compare node level sleeping in order to pave the way to future research.%目前传统网络架构显得越来越臃肿,以致于产生很多的问题,其中能耗问题显得越来越突出。为了解决这些问题,不是对已有的网络架构做修补,而是革命性地更改网络体系架构。国内外已经有部分项目提出了未来网络体系架构,并且在一些新型的网络体系架构下提出了休眠机制,旨在降低能耗。主要介绍了未来网络架构下的休眠方案,同时对节点级休眠方案进行仿真和比较,为以后的研究做铺垫。

  12. An 8-year review of barium studies in the diagnosis of gastroparesis

    Energy Technology Data Exchange (ETDEWEB)

    Levin, A.A. [Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA (United States); Levine, M.S. [Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA (United States)], E-mail: marc.levine@uphs.upenn.edu; Rubesin, S.E.; Laufer, I. [Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA (United States)

    2008-04-15

    Aim: To determine the utility of barium studies for diagnosing gastroparesis in patients with nausea, vomiting, or other related symptoms. Materials and methods: Radiology files revealed gastroparesis without gastric outlet obstruction on upper gastrointestinal tract barium studies in 50 patients with nausea, vomiting, and other related symptoms. Original reports and images were reviewed to determine whether gastric peristalsis was decreased/absent and to investigate gastric dilatation, fluid or debris, and delayed emptying of barium. Twenty patients (40%) had nuclear gastric emptying studies. Medical records were reviewed to determine the presentation, treatment, and course. The diagnosis of gastroparesis was considered accurate if patients with gastroparesis on barium studies responded to treatment. Results: Forty-six patients (92%) had predisposing factors for gastroparesis, including narcotics and diabetes. Forty-five patients (90%) presented with nausea or vomiting, and 40 patients (80%) had one or more other symptoms, including bloating, early satiety, postprandial fullness, and abdominal pain. Barium studies revealed decreased gastric peristalsis in 46 (92%) of the 50 patients and absent peristalsis in four (8%); 46 patients (92%) had additional findings, including gastric dilatation in 30 (60%), delayed emptying of barium in 27 (54%), debris in 28 (56%; bezoars in three), and retained fluid in 13 (26%). Thirteen (65%) of 20 patients with nuclear gastric emptying studies had delayed emptying of solids and seven (35%) had normal emptying. Thirty-five (83%) of 42 patients treated for gastroparesis had symptomatic improvement versus two (25%) of eight patients not treated. Conclusion: Patients with nausea, vomiting, or other related symptoms who have gastroparesis without gastric outlet obstruction on barium studies can be treated for this condition on the basis of the clinical and radiographic findings.

  13. 糖尿病性胃轻瘫的诊治进展%Advances in the Diagnosis and Treatment of Diabetic Gastroparesis

    Institute of Scientific and Technical Information of China (English)

    赵英杰

    2013-01-01

    Diabetic gastroparesis( DGP )is a common complication in diabetics,which may result in poor quality of life. The typical symptoms of DGP are nausea,vomiting,early satiety,bloating and postprandial fullness , which can extremely lower the quality of life. The diagnosis of DGP is made by the presence of delayed gastric emptying,ruling out mechanical obstruction. The gold standard test to diagnose delayed gastric emptying is gastric emptying scintigraphy. The common treatments for DGP include dietary modifications,prokinetic agents and antiemetic agents. Here is to make a review on the progress of clinical manifestation,pathogensis, diagnosis and treatment of DGP.%糖尿病性胃轻瘫(DGP)是糖尿病患者的常见并发症,影响糖尿病患者的生活质量.DGP是糖尿病患者的常见并发症,其主要症状为恶心、呕吐,早饱感及餐后腹胀,可极大地降低患者的生活质量.患者有胃排空延迟症状,排除机械性梗阻的病因即可诊断为胃轻瘫.胃排空闪烁扫描法是诊断胃排空延迟的金标准.DGP的常用治疗措施是饮食调理、促胃动力药、止吐药等.现就DGP的临床表现、发病机制、诊断和治疗进展予以综述.

  14. Meig’s Syndrome:A Triad of Pleural Effusion, Abdominal Ascites, and Benign Ovarian Fibroma

    Institute of Scientific and Technical Information of China (English)

    Yaseen Ali; Amila M. Parekh; Rahul K. Rao; Taseen Ali; Linda S. Schneider; Jordan Garvey; Mirza R. Baig

    2015-01-01

    Background:Meig’s syndrome is a rare syndrome characterized by a triad of recurrent pleural effusions, ascites, and the finding of a benign ovarian fibroma on diagnostic imaging and histopathological evaluation. Patients can present with any of the constellation of symptoms attributing to the disease state. With pleural effusions they can present with shortness of breath, chest pressure, dyspnea on exertion; symptoms that can be confused with the exacerbation of congestive heart failure. Ascites can present with abdominal tenseness, pain, bloating, cramping, constipation, and elevated liver enzymes. The ifnding of a benign ovarian ifbroma is found only during diagnostic imaging and histopathological evaluation. Case report:The patients was an 85-year-old female with a recent history of coronary artery bypass graft surgery for her severe coronary artery disease presented with the chief complaint of generalized malaise, abdominal pain, constipation of few days. She was initially scheduled to have her second therapeutic thoracentesis for her recurrent pleural effusion as an outpatient procedure but complained of the former symptoms and was admitted for observation and treatment of her abdominal symptoms. Her recurrent pleural effusions were initially attributed to the complications of her coronary artery bypass graft surgery for her severe coronary artery disease. During the admission and evaluation she was diagnosed with Meig’s syndrome. She underwent a left oophorectomy with total abdominal hysterectomy that led to the resolution of all her symptoms. Conclusion:Meig’s syndrome is a rare syndrome characterized by the triad of recurrent pleural effusions, ascites, and the ifnding of a benign ovarian ifbroma. The diagnosis and knowledge of this syndrome holds the key to its treatment. The treatment generally involves the resection of the ovarian ifbroma. After the resection of the ovarian ifbroma patients recover from the inconvenient pleural effusions and

  15. [Irritable bowel syndrome with constipation and functional constipation in adults: Treatment (Part 2 of 2)].

    Science.gov (United States)

    Mearin, F; Ciriza, C; Mínguez, M; Rey, E; Mascort, J J; Peña, E; Cañones, P; Júdez, J

    2017-03-01

    In this Clinical practice guide we examine the diagnostic and therapeutic management of adult patients with constipation and abdominal discomfort, at the confluence of the spectrum of irritable bowel syndrome and functional constipation. Both fall within the framework of functional intestinal disorders and have major personal, health and social impact, altering the quality of life of the patients affected. The former is a subtype of irritable bowel syndrome in which constipation and altered bowel habit predominate, often along with recurring abdominal pain, bloating and abdominal distension. Constipation is characterised by infrequent or hard-to-pass bowel movements, often accompanied by straining during defecation or the sensation of incomplete evacuation. There is no underlying organic cause in the majority of cases; it being considered a functional bowel disorder. There are many clinical and pathophysiological similarities between the two conditions, the constipation responds in a similar way to commonly used drugs, the fundamental difference being the presence or absence of pain, but not in an "all or nothing" way. The severity of these disorders depends not only on the intensity of the intestinal symptoms but also on other biopsychosocial factors: association of gastrointestinal and extraintestinal symptoms, degree of involvement, forms of perception and behaviour. Functional bowel disorders are diagnosed using the Rome criteria. This Clinical practice guide adapts to the Rome IV criteria published at the end of May 2016. The first part (96, 97, 98) examined the conceptual and pathophysiological aspects, alarm criteria, diagnostic test and referral criteria between Primary Care and Gastroenterology. This second part reviews all the available treatment alternatives (exercise, fluid ingestion, diet with soluble fibre-rich foods, fibre supplements, other dietary components, osmotic or stimulating laxatives, probiotics, antibiotics, spasmolytics, peppermint

  16. The impact of microbial immune enteral nutrition on the patients with acute radiation enteritis in bowel function and immune status.

    Science.gov (United States)

    Shao, Feng; Xin, Fu-Ze; Yang, Cheng-Gang; Yang, Dao-Gui; Mi, Yue-Tang; Yu, Jun-Xiu; Li, Guo-Yong

    2014-06-01

    The aim of the study was to investigate the effect of microbial immune enteral nutrition by microecopharmaceutics and deep sea fish oil and glutamine and Peptisorb on the patients with acute radiation enteritis in bowel function and immune status. From June 2010 to January 2013, 46 acute radiation enteritis patients in Liaocheng People's Hospital were randomized into the microbial immune enteral nutrition group and the control group: 24 patients in treatment group and 22 patients in control group. The immune microbial nutrition was given to the study group, but not to the control group. The concentration of serum albumin and prealbumin and the number of CD3 (+) T cell, CD4 (+) T cell, CD8 (+) T cell, CD4 (+)/CD8 (+) and natural killer cell of the two groups were detected on the 1, 7 and 14 days after treatment. The arm muscle circumference and triceps skinfold thickness (TSF) were recorded, and the tolerance of the two groups for enteral nutrition and intestinal symptoms was collected and then comparing the two indicators and get results. The tolerance of microbial immune enteral nutrition group about abdominal pain, bloating and diarrhea was better than the control group (P values were 0.018, 0.04 and 0.008 after 7 days; P values were 0.018, 0.015 and 0.002 after 14 days); and the cellular immune parameters were better than the control group((△) P = 0.008,([Symbol: see text]) P = 0.039, (☆) P = 0.032); No difference was found in nutrition indicators. To the patients with acute radiation enteritis, microbial immune enteral nutrition could improve the patient's immune status, and the tolerance of enteral nutrition could be better for the bowel function and the patients' rehabilitation.

  17. Pathophysiology and Therapeutic Strategies for Symptomatic Uncomplicated Diverticular Disease of the Colon.

    Science.gov (United States)

    Scaioli, Eleonora; Colecchia, Antonio; Marasco, Giovanni; Schiumerini, Ramona; Festi, Davide

    2016-03-01

    Colonic diverticulosis imposes a significant burden on industrialized societies. The current accepted causes of diverticula formation include low fiber content in the western diet with decreased intestinal content and size of the lumen, leading to the transmission of muscular contraction pressure to the wall of the colon, inducing the formation of diverticula usually at the weakest point of the wall where penetration of the blood vessels occurs. Approximately 20 % of the patients with colonic diverticulosis develop abdominal symptoms (i.e., abdominal pain and discomfort, bloating, constipation, and diarrhea), a condition which is defined as symptomatic uncomplicated diverticular disease (SUDD). The pathogenesis of SUDD symptoms remains uncertain and even less is known about how to adequately manage bowel symptoms. Recently, low-grade inflammation, altered intestinal microbiota, visceral hypersensitivity, and abnormal colonic motility have been identified as factors leading to symptom development, thus changing and improving the therapeutic approach. In this review, a comprehensive search of the literature regarding on SUDD pathogenetic hypotheses and pharmacological strategies was carried out. The pathogenesis of SUDD, although not completely clarified, seems to be related to an interaction between colonic microbiota alterations, and immune, enteric nerve, and muscular system dysfunction (Cuomo et al. in United Eur Gastroenterol J 2:413-442, 2014). Greater understanding of the inflammatory pathways and gut microbiota composition in subjects affected by SUDD has increased therapeutic options, including the use of gut-directed antibiotics, mesalazine, and probiotics (Bianchi et al. in Aliment Pharmacol Ther 33:902-910, 2011; Comparato et al. in Dig Dis Sci 52:2934-2941, 2007; Tursi et al. in Aliment Pharmacol Ther 38:741-751, 2013); however, more research is necessary to validate the safety, effectiveness, and cost-effectiveness of these interventions.

  18. 热敏灸加耳穴压豆治疗术后自控镇痛尿潴留的观察%Treating postoperative urinary retention inTCM

    Institute of Scientific and Technical Information of China (English)

    莫镇豪; 莫桂英; 林艳珍; 曾燕玲; 唐荣德

    2016-01-01

    目的:分析热敏灸加耳穴压豆治疗术后自控镇痛尿潴留的效果。方法:选取2013年6月-2015年6月100例术后自控镇痛尿潴留患者作为研究对象,根据随机原则分组。参照组患者以常规方法进行处理,研究组患者在常规处理的同时辅以热敏灸加耳穴压豆治疗。对比治疗前和治疗结束后30min患者排尿、尿急、腹痛和腹胀症状积分,并对比疗效。结果:两组患者治疗前症状积分接近,组间差异无统计学意义(P>0.05)。治疗后,两组患者排尿、尿急、腹痛和腹胀症状积分均显著改善,组内差异有统计学意义(P0.05). After treatment, urination, urgency, abdominal pain and bloating symptom scores in two groups were signiifcantly improved (P<0.05). But the margin in the study group was improved (P<0.01).In the study group and the control group, the efifciency were 88.00% and 66.00% (P<0.01) respectively. Conclusion: Thermal moxa plus ear point beans pressure on postoperative showed an exact effect, could effectively improve the symptoms of urinary retention, and was worthy of promotion.

  19. 饲草中缩合单宁的研究进展%Progress in Condensed Tannins of Forage

    Institute of Scientific and Technical Information of China (English)

    朱琳; 陈鑫珠; 张建国

    2012-01-01

    Feeding a high concentration of condensed tannins will reduce protein degradation and voluntary feed intake, damage abomasum or intestine. However, appropriate concentration of condensed tannins have beneficial effects on prevention of bloat and pulmonary edema, reducing parasitic disease and pastoral flavour in meat products, improving animal performance. Condensed tannins are clearly a "double edged sword" for feeding value. Successful management of condensed tannins depends on a combination of chemical analysis and animal experimentation. This paper is a review on nutrition and anti-nutrition of condensed tannins for ruminants, the factors affecting content of condensed tannins in forage, and the methods of controling concentration of condensed tannins. Research on successful management of condensed tannins will offer a real benefit for farmers.%饲料中高浓度的缩合单宁会降低动物对营养物质的消化利用率,影响自愿采食量,甚至损伤肠胃.适宜含量的缩合单宁,又能阻止臌胀病、肺水肿的发生,降低寄生虫病害的影响,改善肉质品味,提高动物的生产性能.论文概述了缩合单宁的营养作用、抗营养作用,影响饲草缩合单宁含量的因素,以及控制缩合单宁含量的方法,以便在实践中合理应用缩合单宁.

  20. Structure and Evolution of Internally Heated Hot Jupiters

    Science.gov (United States)

    Komacek, Thaddeus D.; Youdin, Andrew N.

    2015-11-01

    The transit radii of many close-in extrasolar giant planets, or "hot Jupiters," are systematically larger than those expected from models considering only cooling from an initial high-entropy state. Though these planets receive strong irradiation, with equilibrium temperatures of 1000-2500 Kelvin, the absorption of stellar incident flux in the upper atmosphere alone cannot explain these anomalous radii. More promising mechanisms involve irradiation-driven meteorological activity, which penetrates much deeper into the planet than direct stellar heating. This circulation can lead to large-scale mixing and downward transport of kinetic energy, both processes whereby a fraction of the stellar incident power is transported downwards to the interior of the planet. Here we consider how deposition of heat at different pressure levels or structural locations within a planet affects the resulting evolution. To do so, we run global gas giant evolutionary models with with the stellar structure code MESA including additional energy dissipation. We find that relatively shallow atmospheric heating alone can explain the transit radii of the hot Jupiter sample, but heating in the convective zone is an order of magnitude more efficient regardless of exact location. Additionally, a small difference in atmospheric heating location can have a significant effect on radius evolution, especially near the radiative-convective boundary. The most efficient location to heat the planet is at the radiative-convective boundary or deeper. We expect that shear instabilities at this interface may naturally explain energy dissipation at the radiative-convective boundary, which typically lies at a pressure of ~1 kilobar after 5 Gyr for a planet with the mass and incident stellar flux of HD 209458b. Hence, atmospheric processes are most efficient at explaining the bloated radii of hot Jupiters if they can transport incident stellar power downwards to the top of the inner convective zone.

  1. 马铃薯能生食吗?%Can Potato Be Eaten Raw?

    Institute of Scientific and Technical Information of China (English)

    曾凡逵; 周添红

    2013-01-01

    马铃薯营养丰富,钾和维生素C含量都很高。很多蔬菜既可以生食也可以煮熟后食用。通常,生食的蔬菜鲜嫩多汁且口感清新。然而有些蔬菜很少用来生食,马铃薯就是其中一种。马铃薯可以生食,但带有一点苦味,因此很少有人生食马铃薯。生的马铃薯其内含有的蛋白酶抑制剂具有潜在的治疗癌症的作用,但生食马铃薯的风险也很大,会导致难消化、产气和腹胀、食源性疾病和中毒等现象。%Potatoes are an excellent source of potassium and vitamin C. Many vegetables are commonly consumed raw, as wel as cooked. In general, raw vegetables are bright in color, juicy and fresh flavored. However, there are some vegetables that are seldom eaten raw. Potato is one of those. Although they can be eaten raw, their starchy texture and slight bitterness are unappealing to most. Potato protease inhibitors have the potential application of treatment for cancer, but the risks of eating raw potatoes are present, including indigestibility, gas and bloating, foodborne il ness, and toxicity.

  2. Clinical Practice Guideline: irritable bowel syndrome with constipation and functional constipation in the adult

    Directory of Open Access Journals (Sweden)

    Fermín Mearin

    Full Text Available In this Clinical Practice Guideline we discuss the diagnostic and therapeutic approach of adult patients with constipation and abdominal complaints at the confluence of the irritable bowel syndrome spectrum and functional constipation. Both conditions are included among the functional bowel disorders, and have a significant personal, healthcare, and social impact, affecting the quality of life of the patients who suffer from them. The first one is the irritable bowel syndrome subtype, where constipation represents the predominant complaint, in association with recurrent abdominal pain, bloating, and abdominal distension. Constipation is characterized by difficulties with or low frequency of bowel movements, often accompanied by straining during defecation or a feeling of incomplete evacuation. Most cases have no underlying medical cause, and are therefore considered as a functional bowel disorder. There are many clinical and pathophysiological similarities between both disorders, and both respond similarly to commonly used drugs, their primary difference being the presence or absence of pain, albeit not in an "all or nothing" manner. Severity depends not only upon bowel symptom intensity but also upon other biopsychosocial factors (association of gastrointestinal and extraintestinal symptoms, grade of involvement, and perception and behavior variants. Functional bowel disorders are diagnosed using the Rome criteria. This Clinical Practice Guideline has been made consistent with the Rome IV criteria, which were published late in May 2016, and discuss alarm criteria, diagnostic tests, and referral criteria between Primary Care and gastroenterology settings. Furthermore, all the available treatment options (exercise, fluid ingestion, diet with soluble fiber-rich foods, fiber supplementation, other dietary components, osmotic or stimulating laxatives, probiotics, antibiotics, spasmolytics, peppermint essence, prucalopride, linaclotide, lubiprostone

  3. Spectrum of chronic small bowel diarrhea with malabsorption in Indian subcontinent: is the trend really changing?

    Science.gov (United States)

    Ingle, Meghraj; Rathi, Chetan; Poddar, Prateik; Pandav, Nilesh; Sawant, Prabha

    2016-01-01

    Background/Aims This study aimed to document the recent etiological spectrum of chronic diarrhea with malabsorption and also to compare features that differentiate tropical sprue from parasitic infections, the two most common etiologies of malabsorption in the tropics. Methods We analyzed 203 consecutive patients with malabsorption. The etiological spectrum and factors that differentiated tropical sprue from parasitic infections were analyzed. Results The most common etiology was tropical sprue (n=98, 48.3%) followed by parasitic infections (n=25, 12.3%) and tuberculosis (n=22, 10.8%). Other causes were immunodeficiency (n=15, 7.3%; 12 with human immunodeficiency virus and 3 with hypogammaglobulinemia), celiac disease (n=11, 5.4%), Crohn's disease (n=11, 5.4%), small intestinal bacterial overgrowth (n=11, 5.4%), hyperthyroidism (n=4, 1.9%), diabetic diarrhea (n=4, 1.9%), systemic lupus erythematosus (n=3, 1.4%), metastatic carcinoid (n=1, 0.5%) and Burkitt's lymphoma (n=1, 0.5%). On multivariate analysis, features that best differentiated tropical sprue from parasitic infections were larger stool volume (P=0.009), severe weight loss (P=0.02), knuckle hyperpigmentation (P=0.008), low serum B12 levels (P=0.05), high mean corpuscular volume (P=0.003), reduced height or scalloping of the duodenal folds on endoscopy (P=0.003) and villous atrophy on histology (P=0.04). Presence of upper gastrointestinal (GI) symptoms like bloating, nausea and vomiting predicted parasitic infections (P=0.01). Conclusions Tropical sprue and parasitic infections still dominate the spectrum of malabsorption in India. Severe symptoms and florid malabsorption indicate tropical sprue while the presence of upper GI symptoms indicates parasitic infections. PMID:26884738

  4. Benign Hydronephrosis and Elevated of Serum Levels of Carbohydrate Antigen CA 19-9: A Case Report

    Science.gov (United States)

    Filipovic, Branka; Milinić, Nikola; Gacic, Jasna; Markovic, Olivera; Djokovic, Aleksandra; Filipovic, Branislav

    2016-01-01

    Patient: Male, 58 Final Diagnosis: Hydronephrosis Symptoms: Blunt abdominal pain • constipation • constipation Medication: — Clinical Procedure: Extracorporeal shock wave lithotripsy and percutaneous nephrostolithotomy Specialty: Gastroenterology and Hepatology Objective: Rare co-existance of disease or pathology Background: Carbohydrate tumor-associated antigen (CA 19-9) has been shown to be upregulated in other malignant tumors including gastric, ovarian, hepatocellular, and colorectal carcinoma as well as benign diseases of the biliary track such as pancreatitis, cholangitis, and choledocholithiasis. According to the available literature, in several cases of benign hydronephrosis and in a few cases of benign renal diseases, elevated CA 19-9 has been noted. Case Report: A 58-year-old Caucasian male patient was admitted in our clinic with complaints about blunt abdominal pain in the past two-month period localized in the right lumbar region and irradiating into the right inguinal area, constipation, abdominal bloating, and intermittent hematuria. The concentration of serum CA 19-9 was 3500 U/mL. Urine cytology provided no signs of abnormality. Intravenous urography visualized right-sided pyelon and ureter duplex with the defect in contrast shade of the pyelon, caused by a stag horn calculus. Contrast added computerized axial tomography of the abdomen and pelvis visualized the pyelon casted concretion spreading throughout the right pyelon, with ureterohydronephrosis with the distal block for passage of the contrast to the distal part of the ureter. Conclusions: There is no doubt that CA 19-9 level is occasionally elevated in patients with obstructive urolithiasis as it was in our case. In the routine medical praxis, urolithiasis should not be neglected in the differential diagnosis of elevated concentrations of CA 19-9 marker. PMID:27287959

  5. Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2 regulates axon integrity in the mouse embryo.

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    Amy N Hicks

    Full Text Available Using transposon-mediated gene-trap mutagenesis, we have generated a novel mouse mutant termed Blad (Bloated Bladder. Homozygous mutant mice die perinatally showing a greatly distended bladder, underdeveloped diaphragm and a reduction in total skeletal muscle mass. Wild type and heterozygote mice appear normal. Using PCR, we identified a transposon insertion site in the first intron of Nmnat2 (Nicotinamide mononucleotide adenyltransferase 2. Nmnat2 is expressed predominantly in the brain and nervous system and has been linked to the survival of axons. Expression of this gene is undetectable in Nmnat2(blad/blad mutants. Examination of the brains of E18.5 Nmnat2(blad/blad mutant embryos did not reveal any obvious morphological changes. In contrast, E18.5 Nmnat2(blad/blad homozygotes showed an approximate 60% reduction of spinal motoneurons in the lumbar region and a more than 80% reduction in the sensory neurons of the dorsal root ganglion (DRG. In addition, facial motoneuron numbers were severely reduced, and there was virtually a complete absence of axons in the hind limb. Our observations suggest that during embryogenesis, Nmnat2 plays an important role in axonal growth or maintenance. It appears that in the absence of Nmnat2, major target organs and tissues (e.g., muscle are not functionally innervated resulting in perinatal lethality. In addition, neither Nmnat1 nor 3 can compensate for the loss of Nmnat2. Whilst there have been recent suggestions that Nmnat2 may be an endogenous modulator of axon integrity, this work represents the first in vivo study demonstrating that Nmnat2 is involved in axon development or survival in a mammal.

  6. Irradiated Human Dermal Fibroblasts Are as Efficient as Mouse Fibroblasts as a Feeder Layer to Improve Human Epidermal Cell Culture Lifespan

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    Lucie Germain

    2013-02-01

    Full Text Available A fibroblast feeder layer is currently the best option for large scale expansion of autologous skin keratinocytes that are to be used for the treatment of severely burned patients. In a clinical context, using a human rather than a mouse feeder layer is desirable to reduce the risk of introducing animal antigens and unknown viruses. This study was designed to evaluate if irradiated human fibroblasts can be used in keratinocyte cultures without affecting their morphological and physiological properties. Keratinocytes were grown either with or without a feeder layer in serum-containing medium. Our results showed that keratinocytes grown either on an irradiated human feeder layer or irradiated 3T3 cells (i3T3 can be cultured for a comparable number of passages. The average epithelial cell size and morphology were also similar. On the other hand, keratinocytes grown without a feeder layer showed heavily bloated cells at early passages and stop proliferating after only a few passages. On the molecular aspect, the expression level of the transcription factor Sp1, a useful marker of keratinocytes lifespan, was maintained and stabilized for a high number of passages in keratinocytes grown with feeder layers whereas Sp1 expression dropped quickly without a feeder layer. Furthermore, gene profiling on microarrays identified potential target genes whose expression is differentially regulated in the absence or presence of an i3T3 feeder layer and which may contribute at preserving the growth characteristics of these cells. Irradiated human dermal fibroblasts therefore provide a good human feeder layer for an effective expansion of keratinocytes in vitro that are to be used for clinical purposes.

  7. 运脾化湿法治疗小儿脾虚腹泻40例临床观察%Clinical observation on treating 40 cases of infantile diarrhea in TCM

    Institute of Scientific and Technical Information of China (English)

    王利然

    2015-01-01

    目的:观察运脾化湿法治疗小儿脾虚腹泻的临床疗效。方法:将80例脾虚腹泻患儿随机分为治疗组和对照组各40例,治疗组患儿用运脾化湿方直肠滴入进行治疗,对照组患儿给予金双歧片和蒙脱石散,两组均治疗6d 后,观察大便次数及伴随症状改善情况。结果:治疗组总有效率95%明显优于对照组总有效率80%,P<0.05;治疗组在缓解腹胀、腹痛、呕吐、食欲不振症状上优于对照组,P<0.05。结论:运脾化湿法治疗小儿脾虚腹泻疗效确切。%Objective:To observe the clinical efficacy of TCM treatment for diarrhea. Methods:80 patients were randomly divided into treatment group 40 cases, treated in TCM treatment, and the control group was given Jinshuangqi and smecta both for 6 days. Results:The total efficiency of 95%was significantly better than the control group (total efficiency of 80%), P<0.05;at bloating, abdominal pain, vomiting, loss of appetite treatment group was better, P<0.05. Conclusion: The Yunpi Huashi therapy for children with diarrhea was effective.

  8. Clinical research of the dermal pedicle nasolabial flap%真皮蒂鼻唇沟皮瓣的临床应用研究

    Institute of Scientific and Technical Information of China (English)

    陈誉华

    2011-01-01

    Objective To improve the traditional nasolabial flap, and to explore the value of clinical application of the dermal pedicle nasolabial flap. Methods Dermal pedicle nasolabial flap was designed to repair the small area defects of skin and soft tissues in nose and lips (43 cases). Results All the flaps survived completely with slight scar and satisfactory results, 6 to 12 months follow up reviewed that the color and elastic and texture of the flaps were similar to the skin around defects. Conclusion Because of the advantages of dermal pedicle nasolabial flap such as small damage to donor areas, quick recovery.flexible for transferring,low incidence of subcutaneous tunnel bloated, slight scar,it had wide application prospects in the repair of small area defects.%改良传统鼻唇沟皮瓣,探讨真皮蒂鼻唇沟皮瓣的临床应用价值.方法:设计以真皮组织作为蒂部的真皮蒂鼻唇沟皮瓣43例,用于修复鼻唇部皮肤软组织小面积缺损.结果:皮瓣全部成活,切口Ⅰ期愈合,随访6~12个月,术后皮瓣色泽、弹性、质地与周围组织接近,瘢痕不明显,修复效果满意.结论:真皮蒂鼻唇沟皮瓣修复鼻唇部缺损具有供区损伤小、恢复快,转移灵活,术后皮下隧道臃肿发生率低,瘢痕不明显等优点,在对鼻唇周围小面积缺损修复中具有广阔的应用前景.

  9. Gastrointestinal manifestations in myotonic muscular dystrophy

    Institute of Scientific and Technical Information of China (English)

    Massimo Bellini; Sonia Biagi; Cristina Stasi; Francesco Costa; Maria Gloria Mumolo; Angelo Ricchiuti; Santino Marchi

    2006-01-01

    Myotonic dystrophy (MD) is characterized by myotonic phenomena and progressive muscular weakness.Involvement of the gastrointestinal tract is frequent and may occur at any level. The clinical manifestations have previously been attributed to motility disorders caused by smooth muscle damage, but histologic evidence of alterations has been scarce and conflicting.A neural factor has also been hypothesized. In the upper digestive tract, dysphagia, heartburn, regurgitation and dyspepsia are the most common complaints, while in the lower tract, abdominal pain, bloating and changes in bowel habits are often reported. Digestive symptoms may be the first sign of dystrophic disease and may precede the musculo-skeletal features. The impairment of gastrointestinal function may be sometimes so gradual that the patients adapt to it with little awareness of symptoms. In such cases routine endoscopic and ultrasonographic evaluations are not sufficient and targeted techniques (electrogastrography, manometry,electromyography, functional ultrasonography,scintigraphy, etc.) are needed. There is a low correlation between the degree of skeletal muscle involvement and the presence and severity of gastrointestinal disturbances whereas a positive correlation with the duration of the skeletal muscle disease has been reported.The drugs recommended for treating the gastrointestinal complaints such as prokinetic, antidyspeptic drugs and laxatives, are mainly aimed at correcting the motility disorders.Gastrointestinal involvement in MD remains a complex and intriguing condition since many important problems are still unsolved. Further studies concentrating on genetic aspects, early diagnostic techniques and the development of new therapeutic strategies are needed to improve our management of the gastrointestinal manifestations of MD.

  10. Irritable bowel syndrome neuropharmacology. A review of approved and investigational compounds.

    Science.gov (United States)

    Callahan, Michael J

    2002-07-01

    Anticholinergics and prokinetics are mainstays of therapy for Irritable Bowel Syndrome (IBS) patients despite their limited efficacy and troublesome side-effect profile. The clinical limitations of these drugs are a result of their relative broad and nonspecific pharmacologic interaction with various receptors. Recent advances in gut physiology have led to the identification of various receptor targets that may play a pivotal role in the pathogenesis of IBS. Medicinal chemists searching for safe and effective IBS therapies are now developing compounds targeting many of these specific receptors. The latest generation of anticholinergics, such as zamifenacin, darifenacin, and YM-905, provide selective antagonism of the muscarinic type-3 receptor. Tegaserod, a selective 5-HT4 partial agonist, tested in multiple clinical trials, is effective in reducing the symptoms of abdominal pain, bloating, and constipation. Ezlopitant and nepadudant, selective antagonists for neurokinin receptors type 1 and type 2, respectively, show promise in reducing gut motility and pain. Loperamide, a mu (mu) opioid receptor agonist, is safe and effective for IBS patients with diarrhea (IBS-D) as the predominant bowel syndrome. Fedotozine, a kappa (kappa) opioid receptor agonist, has been tried as a visccral analgesic in various clinical trials with conflicting results. Alosetron, a 5-HT3 receptor antagonist, has demonstrated efficacy in IBS-D patients but incidents of ischemic colitis seen in post-marketing follow-up resulted its removal from the market. Compounds that target cholecystokinin. A, N-methyl-D-aspartate, alpha 2-adrenergic, and corticotropin-releasing factor receptors are also examined in this review.

  11. Subjective lactose intolerance in apparently healthy adults in southern Iran: Is it related to irritable bowel syndrome?

    Directory of Open Access Journals (Sweden)

    Saberi-Firoozi M

    2007-11-01

    Full Text Available Background : The main symptoms of lactose intolerance are bloating, abdominal cramps, increased flatus and loose watery stools. These symptoms are similar to those of irritable bowel syndrome (IBS, which is a prevalent entity in the community. Objective : As there was no data available on the prevalence of LI and the correlated factors, this study aimed to determine these correlations and their relation to IBS symptoms in an apparently healthy population in Shiraz, southern Iran. Materials and Methods : A survey among 1,978 individuals older than 35 years was conducted in Shiraz, southern Iran, using a questionnaire that consisted of items regarding demographic data, life style, subjective gastrointestinal symptoms of LI and IBS symptoms according to ROME II criteria. Results : A total of 562 subjects reported LI (28.41%. The prevalence was significantly higher in females, in subjects taking NSAIDs or acetaminophen and in cases reporting IBS symptoms. Subjects with LI avoided certain foods and drinks; and in order to relieve their symptoms, they used OTC drugs, herbal medicine or visited a physician. On the other hand, no relation was found between LI and age, smoking or the number of meals per day. Conclusions : Although we found that individuals with IBS had significantly more subjective LI than those without IBS, in the absence of documented lactose malabsorption, it is hard to tell whether the reported symptoms indeed are those of LI or simply those of IBS. So, a period of dairy product avoidance and/ or requesting a test for lactose malabsorption may be beneficial in this area.

  12. Application of Cotton Masks in the Use of Bipap%棉口罩在无创呼吸机使用过程中的应用

    Institute of Scientific and Technical Information of China (English)

    仲洁明

    2014-01-01

    [ABSTRACT]Objective:Explord the thin cotton masks to increase patients’ comfort in the process of using Bipap. Methods:Analyzed and compared patients’ between 2012 December to 2013 December, 258 cases with the addition of a thin cotton mask method and 2011 December~2012 December, 252 cases used routine methods in our department. Results:There are signiifcant differences between the two methods of discomfort in facial pressure ulcer, ocular discomfort and abdominal distension etc. Conclusion:By wearing the medical thin cotton mask can effectively reduce the face pressure ulcer,pneumatic,ophthalmia and bloating etc.Improved the patients’ comfort.%目的:探索佩戴薄棉口罩在使用无创呼吸机过程中增加患者舒适度的作用。方法:对我科2012年12月~2013年12月258例加用薄棉口罩法与2011年12月~2012年12月,252例使用常规佩戴法两种方法进行分析比较。结果:两种方法在发生面部压疮、眼部不适以及腹胀等不适方面存在显著差异。结论:通过佩戴医用薄棉口罩可以有效降低由于佩戴无创呼吸机面罩引起的面部压疮、刺激性结膜炎及腹胀等不适,提高患者的舒适度。

  13. Gastrointestinal symptoms are still prevalent and negatively impact health-related quality of life: a large cross-sectional population based study in The Netherlands.

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    Merel M Tielemans

    Full Text Available BACKGROUND: Over the last decades important risk factors for gastrointestinal symptoms have shifted, which may have changed its population prevalence. The aim of this study was to assess the current prevalence of gastrointestinal symptoms, appraise associated factors and assess health-related quality of life in the general population. METHODS: A total of 51,869 questionnaires were sent to a representative sample of the Dutch adult general population in December 2008. Demographic characteristics, gastrointestinal symptoms, health-related quality of life, medication use and co-morbidity were reported. We used multivariable logistic regression analysis to determine factors associated with gastrointestinal symptoms. RESULTS: A total of 18,317 questionnaires were returned, and 16,758 were eligible for analysis. Prevalence of gastrointestinal symptoms was 26%. Most frequent symptoms were bloating (63%, borborygmi (60% and flatulence (71%. Female gender (adjusted OR (aOR 1.59, 95% CI 1.43-1.77, asthma/COPD (aOR 1.47, 95% CI 1.21-1.79, use of paracetamol (aOR 1.33, 95% CI 1.20-1.47, antidepressants (aOR 1.56, 95% CI 1.22-2.00 and acid-suppressive medication were independently associated with presence of gastrointestinal symptoms. Age over 65 years (aOR 0.75, 95% CI 0.65-0.87, and use of statins (aOR 0.75, 95% CI 0.61-0.93 were associated with a lower prevalence of gastrointestinal symptoms. Respondents with gastrointestinal symptoms had a lower mean health-related quality of life of 0.81 (SD = 0.21 compared to 0.92 (SD = 0.14 for persons without gastrointestinal symptoms (P<0.01. CONCLUSIONS: Prevalence of gastrointestinal symptoms in the Dutch community is high and associated with decreased health-related quality of life.

  14. Irritable bowel syndrome subtypes: clinical and psychological features, body mass index and comorbidities

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    Cristiane Kibune-Nagasako

    2016-02-01

    Full Text Available Background: Irritable bowel syndrome (IBS is classified into subtypes according to bowel habit. Objective: To investigate whether there are differences in clinical features, comorbidities, anxiety, depression and body mass index (BMI among IBS subtypes. Methods: The study group included 113 consecutive patients (mean age: 48 ± 11 years; females: 94 with the diagnosis of IBS. All of them answered a structured questionnaire for demographic and clinical data and underwent upper endoscopy. Anxiety and depression were assessed by the Hospital Anxiety and Depression scale (HAD. Results: The distribution of subtypes was: IBS-diarrhea (IBS-D, 46%; IBS-constipation (IBS-C, 32%, and mixed IBS (IBS-M, 22%. IBS overlap with gastroesophageal reflux disease (GERD, functional dyspepsia, chronic headache and fibromyalgia occurred in 65.5%, 48.7%, 40.7% and 22.1% of patients, respectively. Anxiety and/or depression were found in 81.5%. Comparisons among subgroups showed that bloating was significantly associated with IBS-M compared to IBS-D (odds ratio-OR-5.6. Straining was more likely to be reported by IBS-M (OR 15.3 and IBS-C (OR 12.0 compared to IBS-D patients, while urgency was associated with both IBS-M (OR 19.7 and IBS-D (OR 14.2 compared to IBS-C. In addition, IBS-M patients were more likely to present GERD than IBS-D (OR 6.7 and higher scores for anxiety than IBS-C patients (OR 1.2. BMI values did not differ between IBS-D and IBS-C. Conclusion: IBS-M is characterized by symptoms frequently reported by both IBS-C (straining and IBS-D (urgency, higher levels of anxiety, and high prevalence of comorbidities. These features should be considered in the clinical management of this subgroup.

  15. Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study.

    Science.gov (United States)

    Mendel, M; Chłopecka, M; Dziekan, N; Karlik, W

    2016-09-01

    Flavonoid supplementation is likely to be beneficial in improving rumen fermentation and in reducing the incidence of rumen acidosis and bloat. Flavonoids are also said to increase the metabolic performance during the peripartum period. Ruminants are constantly exposed to flavonoids present in feed. However, it is not clear if these phytochemicals can affect the activity of the gut smooth muscle. Therefore, the aim of the study was to verify the effect of three flavonoids on bovine isolated abomasum smooth muscle. The study was carried out on bovine isolated circular and longitudinal abomasal smooth muscle specimens. All experiments were conducted under isometric conditions. The effect of apigenin, luteolin and quercetin (0.001 to 100 µM) was evaluated on acetylcholine-precontracted preparations. The effect of multiple, but not cumulative, treatment and single treatment with each flavonoid on abomasum strips was compared. Apigenin (0.1 to 100 µM) dose-dependently showed myorelaxation effects. Luteolin and quercetin applied in low doses increased the force of the ACh-evoked reaction. However, if used in high doses in experiments testing a wide range of concentrations, their contractile effect either declined (luteolin) or was replaced by an antispasmodic effect (quercetin). Surprisingly, the reaction induced by flavonoids after repeated exposure to the same phytochemical was not reproducible in experiments testing only single exposure of abomasum strips to the same flavonoid used in a high concentration. Taking into account the physicochemical properties of flavonoids, this data suggests the ability of flavonoids to interfere with cell membranes and, subsequently, to modify their responsiveness. Assuming ruminant supplementation with luteolin or quercetin or their presence in daily pasture, a reduction of the likelihood of abomasum dysmotility should be expected.

  16. Mast cell stabilizers as a potential treatment for Irritable bowel syndrome: A randomized placebo-controlled clinical trial

    Directory of Open Access Journals (Sweden)

    N Ebrahimi Daryani

    2009-08-01

    Full Text Available Objectives: Mast cells are believed to play a role in irritable bowel syndrome pathogenesis and symptom genesis due to their close neighborhood to gastrointestinal innervations. This study was designed to evaluate the efficacy of orally administered cromolyn for reduction of symptoms in patients with irritable bowel syndrome (IBS. Material and Methods s: A randomized placebo-controlled double-blinded 6×6 weeks cross-over study was performed in a private gastrointestinal clinic. 10 patients were allocated to group A and 6 patients to group B. Patients in group A received 150 mg cromolyn divided in three equal doses for the first 6 weeks and placebo for the next 6 weeks but patients in group B received placebo for the first 6 weeks and cromolyn in the next 6 weeks. Weekly evaluation was performed and visual analogue scale was used to determine severity of symptoms. Results: Sixteen patients completed the study. Mean age of the patients was 40.3 ± 10.9 years old [range: 24-57]. Eight patients had D-IBS (Diarrhea dominant and other 8 had C-IBS (Constipation dominant. Both cromolyn sodium and the placebo decreased the severity of bloating (Freidman test, p 0.001 and 0.006 respectively. The severity of the main symptom (diarrhea or constipation did not decrease in patients of group A and B who were treated with different sequences of the drug or placebo. The severity of pain decreased drastically after 6th week of treatment with cromolyn. Freidman test showed a significant difference between the pain levels of the former defined treatment spots (p 0.01, and 0.02 for patients in group A and B, respectively. No adverse drug reactions were observed during the study. Conclusion: In conclusion, long term administration of cromolyn seems to be partially effective for treatment of abdominal pain in patients with IBS while main symptoms (diarrhea or constipation might not decrease during this treatment.

  17. Polyethylene glycol 3350 in occasional constipation: A one-week, randomized, placebo-controlled, double-blind trial

    Institute of Scientific and Technical Information of China (English)

    Thomas Mc Graw

    2016-01-01

    AIM:to evaluate the efficacy and safety of polyethylene glycol(PEG)3350 in subjects with self-reported occasional constipation.METHODS:Eligible subjects≥17 years of age were randomized to receive either placebo or PEG 335017 g once daily in this multicenter,double-blind trial.Evaluations were conducted before(baseline)and after a 7-d treatment period.The primary efficacy variable was the proportion of subjects reporting complete resolution of straining and hard or lumpy stools.Secondary efficacy variables assessed the severity of the subjects’daily bowel movement(BM)symptoms,and preference of laxatives based on diary entries,visual analog scale scores,and questionnaires.RESULTS:Of the 203 subjects enrolled in the study,11had major protocol violations.Complete resolution was noted by 36/98(36.7%)subjects in the PEG 3350 group and 23/94(24.5%)in the placebo group(P=0.0595).The number of complete BMs without straining or lumpy stools was similar between both groups.Subjects receiving PEG 3350 experienced significant relief in straining and reduction in hardness of stools over a7-d period(P<0.0001).Subjects reported that PEG3350 had a better effect on their daily lives,provided better control over a BM,better relief from constipation,cramping,and bloating,and was their preferred laxative.Adverse events(AEs)were balanced between the PEG3350 and the placebo groups.No deaths,serious AEs,or discontinuations due to AEs were reported.This trial is registered at clinicaltrials.gov as NCT00770432.CONCLUSION:Oral administration of 17 g PEG3350 once daily for a week is effective,safe,and well tolerated in subjects with occasional constipation.

  18. Rifaximina nel trattamento della malattia diverticolare: potenziale terapeutico ed economico

    Directory of Open Access Journals (Sweden)

    Orietta Zaniolo

    2005-03-01

    Full Text Available Antibiotics are commonly used to treat major inflammatory complications of diverticular disease, but apparently there is no rationale for the use of antibiotic therapy in uncomplicated disease, where an inflammatory component is by definition excluded. Some observations suggest a possible role of gut microflora in determining some symptoms related to diverticular disease: bacterial overgrowth, amplifying gas production and bacterial degradation of fibres, could determine bloating, pain and high fecal density. Therefore a beneficial antibiotic action on diverticular disease symptoms can be hypothesized. In this paper pharmacokinetic, pharmacodinamic and therapeutic potential of an intestinal antibiotic, rifaximin, are reviewed. Rifaximin is a rifamycin derivative which acts by inhibiting bacterial ribonucleic acid (RNA synthesis. It is virtually unabsorbed after oral administration and in vitro data indicate it to possess a broad spectrum of action; bacterial resistance during exposure to rifaximin has been reported but its clinical importance remains to be fully defined. The results of placebo-controlled clinical trials show that cyclic administration of rifaximin is more effective in reducing symptoms and in preventing complications than fibre supplementation alone; the drug appears to be well tolerated and safe. We consider the clinical implications and economical impact of diverticulosis on the Italian National Health System and the patient, with a particular attention on the cost of hospitalization, surgery and global management of diverticulitis and other common disease complications. The hypothetic savings correlated to the reduction of complications incidence, attainable with rifaximin use have been calculated and the comparison between the different acquisition costs of the drug frequently used to treat the diverticular disease is provided. Finally we reviewed some quality of life trials in which the psychological and sociological

  19. Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.

    Science.gov (United States)

    Luhmann, Ulrich F O; Carvalho, Livia S; Robbie, Scott J; Cowing, Jill A; Duran, Yanai; Munro, Peter M G; Bainbridge, James W B; Ali, Robin R

    2013-02-01

    Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been implicated in the pathogenesis of age-related macular degeneration. Defects in Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling cause enhanced accumulation of bloated subretinal microglia/macrophages in senescent mice and this phenomenon is reported to result in the acceleration of age-related retinal degeneration. The purpose of this study was to determine whether defects in CCL2-CCR2 and CX3CL1-CX3CR1 signalling pathways, alone or in combination, cause age-dependent retinal degeneration. We tested whether three chemokine knockout mouse lines, Ccl2(-/-), Cx3cr1(-/-) and Ccl2(-/-)/Cx3cr1(-/-), in comparison to age-matched C57Bl/6 control mice show differences in subretinal macrophage accumulation and loss of adjacent photoreceptor cells at 12-14 months of age. All mouse lines are derived from common parental strains and do not carry the homozygous rd8 mutation in the Crb1 gene that has been a major confounding factor in previous reports. We quantified subretinal macrophages by counting autofluorescent lesions in fundus images obtained by scanning laser ophthalmoscopy (AF-SLO) and by immunohistochemistry for Iba1 positive cells. The accumulation of subretinal macrophages was enhanced in Ccl2(-/-), but not in Cx3cr1(-/-) or Ccl2(-/-)/Cx3cr1(-/-) mice. We identified no evidence of retinal degeneration in any of these mouse lines by TUNEL staining or semithin histology. In conclusion, CCL2-CCR2 and/or CX3CL1-CX3CR1 signalling defects may differentially affect the trafficking of microglia and macrophages in the retina during ageing, but do not appear to cause age-related retinal degeneration in mice.

  20. Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine.

    Science.gov (United States)

    Saha, Lekha

    2014-06-14

    Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder that affects 9%-23% of the population across the world. The percentage of patients seeking health care related to IBS approaches 12% in primary care practices and is by far the largest subgroup seen in gastroenterology clinics. It has been well documented that these patients exhibit a poorer quality of life and utilize the health care system to a greater degree than patients without this diagnosis. The pathophysiology of IBS is not clear. Many theories have been put forward, but the exact cause of IBS is still uncertain. According to the updated ROME III criteria, IBS is a clinical diagnosis and presents as one of the three predominant subtypes: (1) IBS with constipation (IBS-C); (2) IBS with diarrhea (IBS-D); and (3) mixed IBS (IBS-M); former ROME definitions refer to IBS-M as alternating IBS (IBS-A). Across the IBS subtypes, the presentation of symptoms may vary among patients and change over time. Patients report the most distressing symptoms to be abdominal pain, straining, myalgias, urgency, bloating and feelings of serious illness. The complexity and diversity of IBS presentation makes treatment difficult. Although there are reviews and guidelines for treating IBS, they focus on the efficacy of medications for IBS symptoms using high-priority endpoints, leaving those of lower priority largely unreported. Therefore, the aim of this review is to provide a comprehensive evidence-based review of the diagnosis, pathogenesis and treatment to guide clinicians diagnosing and treating their patients.

  1. Comparative study of intestinal flora in students from air force school before and after flight training%航校空军学员飞行训练前后肠道菌群的对比研究

    Institute of Scientific and Technical Information of China (English)

    李仕英; 张海谱; 王缚鲲; 季雯; 朱庆尧

    2012-01-01

    significantly decreased as compared with that in the ground staff (P< 0. 05) , Enterococci and Bacteroides increased significantly (Enterococci P<0. 01; Bact eroide P<0. 05); there were no statistical significance among other bacteria; as compared with the students with mental stress and the students with relaxation, the difference in the number of Bifidobacterium, Enterococci, Peptococcus and Bacteroide was statistically significant (P < 0. 05) ; as compared with the students with significant abdominal bloating and the student without abdominal bloating, the difference in the number of Bifidobacterium, Enterococci and Peptococcus was statistically significant (P<0. 05). CONCLUSION Diet as well as the mental status and abdominal bloating is one of the causes of the imbalance of intestinal flora in air force school pilots.

  2. Clinical effect of Pigtail catheter closed thoracic drainage therapyin the treatment of pneumothorax%猪尾导管行胸腔闭式引流治疗气胸的临床效果

    Institute of Scientific and Technical Information of China (English)

    于子翔

    2016-01-01

    Objective: To analyze the effect of the pigtail catheter closed thoracic drainagein the treatment of pneumothorax. Methods: 80 cases with pneumothorax admitted in our hospital from May 2014 to May 2015 were divided into a control group and observation group, 40 cases in each group.The control group received silicone drainage tubes treatment using thoracic drainage and the observation group received pigtail catheter using thoracic drainage. After the drainage treatment, the results between two groups of patients were analyzed. Result: In the long hospital stay, chest rate, subcutaneous emphysema, pleural reaction and bloating pulmonary edema, the observation group was better than the control group,P<0.05. Conclusion: The pigtail catheter pneumothorax thoracic drainage therapy can alleviate the patient's condition very quickly and effectively, reducing the adverse effects and enhancing the quality of treatment.%目的:分析猪尾导管行胸腔闭式引流治疗气胸的效果。方法:研究我院2014年5月—2015年5月接诊的80例气胸患者,分为对照组和观察组各40例,其中对照组采用硅胶引流管做胸腔闭式引流,观察组运用猪尾导管胸腔闭式引流,而后分析两组患者的引流治疗效果。方法:在住院时长、胸痛率、皮下气肿、堵管、胸膜反应和腹胀性肺水肿情况上,观察组均优于对照组,P<0.05。结论:猪尾导管行胸腔闭式引流治疗气胸可以尽快缓解患者病情,同时减少不良反应,提升治疗质量。

  3. Spatial distribution of charged particles along the ion-optical axis in electron cyclotron resonance ion sources. Experimental results

    Energy Technology Data Exchange (ETDEWEB)

    Panitzsch, Lauri

    2013-02-08

    The experimental determination of the spatial distribution of charged particles along the ion-optical axis in electron cyclotron resonance ion sources (ECRIS) defines the focus of this thesis. The spatial distributions of different ion species were obtained in the object plane of the bending magnet ({approx}45 cm downstream from the plasma electrode) and in the plane of the plasma electrode itself, both in high spatial resolution. The results show that each of the different ion species forms a bloated, triangular structure in the aperture of the plasma electrode. The geometry and the orientation of these structures are defined by the superposition of the radial and axial magnetic fields. The radial extent of each structure is defined by the charge of the ion. Higher charge states occupy smaller, more concentrated structures. The total current density increases towards the center of the plasma electrode. The circular and star-like structures that can be observed in the beam profiles of strongly focused, extracted ion beams are each dominated by ions of a single charge state. In addition, the spatially resolved current density distribution of charged particles in the plasma chamber that impinge on the plasma electrode was determined, differentiating between ions and electrons. The experimental results of this work show that the electrons of the plasma are strongly connected to the magnetic field lines in the source and thus spatially well confined in a triangular-like structure. The intensity of the electrons increases towards the center of the plasma electrode and the plasma chamber, as well. These electrons are surrounded by a spatially far less confined and less intense ion population. All the findings mentioned above were already predicted in parts by simulations of different groups. However, the results presented within this thesis represent the first (and by now only) direct experimental verification of those predictions and are qualitatively transferable to

  4. Observation of Zhengtiziyang decoction on malnutrition in hemodialysis patients%整体滋养汤治疗尿毒症血液透析患者营养不良38例临床研究

    Institute of Scientific and Technical Information of China (English)

    杜冬慧; 张翠萍

    2011-01-01

    Objective To observe the effect of Zhengtiziyang decoction on malnutrition in hemodialysis patients. Methods 76 cases of malnutrition in hemodialysis were randomly divided into two groups. 38 patients in control group were treated by maintenance treatment of hemodialysis and high - energy high - protein diet. 38 cases in treatment group were given combination of routine therapy and Zhengtiziyang decoction. The course was twenty days in two groups. The therapeutic effect was evaluated after two courses. Results The improvement rate including apathetic, poor appetite, bloating and fatigue after treatment was higher than that before treatment in two groups ( P <0.05). The levels of albumin precursor, albumin, Tf, TC and hemoglobin after treatment in treatment group was higher than that before treatment and after treatment in .control group ( P < 0.05 ). Conclusion Zhengtiziyang decoction can obvious improve malnutrition in hemodialysis patients.%目的 观察整体滋养汤治疗尿毒症血液透析(HD)患者营养不良的临床疗效.方法 将76例尿毒症HD营养不良患者随机分为2组.对照组38例予常规充分HD维持治疗及高能量优质蛋白饮食治疗,治疗组38例在对照组治疗基础上予自拟整体滋养汤.2组均治疗20 d为1个疗程,2个疗程后观察2组临床症状改善情况,并对营养状况进行评估.结果 2组治疗后精神萎靡、纳少、腹胀及乏力改善率均高于对照组(P<0.05).治疗组治疗后前白蛋白、白蛋白、转铁蛋白、总胆固醇及血红蛋白均较本组治疗前、对照组治疗后升高(P<0.05).结论 整体滋养汤可明显改善尿毒症HD患者营养不良状况.

  5. Semi-obstrução intestinal por esclerodermia: relato de caso

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    Juliana Mendes Cardoso

    2006-06-01

    Full Text Available A esclerodermia ou esclerose sistêmica progressiva é uma doença auto-imune de causa desconhecida que se caracteriza por fibrose da pele, vasos sanguíneos e de alguns outros órgãos, como os pulmões, coração, rins e trato gastrintestinal. Sintomas atribuíveis ao comprometimento gastrintestinal podem estar presentes em até 50% dos pacientes, sendo os mais freqüentes, relacionados às manifestações esofagianas e anorretais. Anormalidades na motilidade intestinal com freqüência levam a desnutrição, supercrescimento bacteriano e quadro de pseudo-obstrução ou mesmo semi-obstrução intestinal. É apresentado um caso de paciente com esclerodermia há 43 anos, evoluindo com quadro de semi-obstrução, apresentando distensão abdominal, cólicas recorrentes e desnutrição grave. Sem resposta ao tratamento clínico foi submetida à cirurgia que evidenciou quadro obstrutivo por comprometimento ileal, o qual foi tratado por bypass íleo-cólico. Lesão intestinal por esclerodermia levando a quadro de obstrução é raramente descrita na literatura médica e, portanto, o tratamento de escolha ainda não foi definido.Scleroderma or progressive systemic sclerosis (PSS is a self-immune illness of unknown cause that is characterized by fibrosis of the skin, blood vessels and some other tissues like the lungs, heart, kidneys and gastrointestinal system. Attributable symptoms to the gastrointestinal involvement can be present in up to 50% of the patients, esophageal and anorectal manifestations being more frequent. Abnormalities in the intestinal motility frequently lead to malnutrition, bacterial over-growth and intestinal pseudo-obstruction. We report a case of scleroderma with intestinal pseudo-obstruction presenting chronic abdominal cramps, bloating and malnutrition with no response to clinical approach. Patient underwent surgery with diagnosis of intestinal obstruction by annular ileal fibrosis treated by ileocolic bypass. Intestinal

  6. Self-medication with antibiotics for the treatment of menstrual symptoms in southwest Nigeria: a cross-sectional study

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    Otivhia Elizabeth

    2010-10-01

    Full Text Available Abstract Background Self-medication with antibiotics is an important factor contributing to the development of bacterial antibiotic resistance. The purpose of this study was to evaluate the prevalence of self-medication with antibiotics for the treatment of menstrual symptoms among university women in Southwest Nigeria. Methods A cross-sectional survey was administered to female undergraduate and graduate students (n = 706 at four universities in Southwest Nigeria in 2008. The universities were selected by convenience and the study samples within each university were randomly selected cluster samples. The survey was self-administered and included questions pertaining to menstrual symptoms, analgesic and antibiotic use patterns, and demographics. Data were analyzed using descriptive statistics and logistic regression. Results The response rate was 95.4%. Eighty-six percent (95% CI: 83-88% of participants experienced menstrual symptoms, and 39% (95% CI: 36-43% reported using analgesics to treat them. Overall, 24% (95% CI: 21-27% of participants reported self-medicated use of antibiotics to treat the following menstrual symptoms: cramps, bloating, heavy bleeding, headaches, pimples/acne, moodiness, tender breasts, backache, joint and muscle pain. Factors associated with this usage were: lower levels of education (Odds Ratio (OR: 2.8, 95% CI: 1.1-7.1, p-value: 0.03; non-science major (OR: 1.58, 95% CI: 1.03-2.50, p-value: 0.04; usage of analgesics (OR: 3.17, 95% CI: 2.07-4.86, p-value: p-value: 0.05 and pimples/acne (OR: 1.57, 95% CI: 0.98-2.54, p-value: 0.06. Ampicillin, tetracycline, ciprofloxacin and metronidazole were used to treat the most symptoms. Doctors or nurses (6%, 95% CI: 4-7%, friends (6%, 95% CI: 4-7% and family members (7%, 95% CI: 5-8% were most likely to recommend the use of antibiotics for menstrual symptoms, while these drugs were most often obtained from local chemists or pharmacists (10.2%, 95% CI: 8-12%. Conclusions This is

  7. Characteristics and risk factors for symptomatic Giardia lamblia infections in Germany

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    Stark Klaus

    2010-01-01

    Full Text Available Abstract Background In developed countries, giardiasis is considered a travel related disease. However, routine surveillance data from Germany indicate that >50% of infections were acquired indigenously. We studied the epidemiological characteristics of symptomatic Giardia infections acquired in Germany and abroad, and verified the proportion of cases acquired in Germany in order to investigate risk factors for sporadic autochthonous Giardia infections. Methods We identified Giardia cases notified by 41 local health authorities between February 2007 and January 2008 and interviewed them on their clinical symptoms, underlying morbidities, travel abroad and potential risk factors for the disease. We conducted a case-control-study including laboratory-confirmed (microscopy or antigen-test autochthonous Giardia cases with clinical manifestations (diarrhoea, cramps, bloating and randomly selected controls from the local population registry matched by county of residence and age-group (0-5, 6-19, ≥20 years. Secondary cases, controls with diarrhoea and persons who had travelled outside Germany in the three weeks prior to disease onset (exposure period were excluded. We calculated adjusted odds ratios (aOR with 95% confidence intervals (CI using conditional logistic regression. Results Of 273 interviewed cases, 131 (48% had not travelled abroad during the defined exposure period. Of these 131, 85 (65% were male, 68 (54% were living in communities with >100,000 inhabitants and 107 (83% were aged 20 years or older. We included 120 cases and 240 controls in the case-control study. Cases were more likely to be male (aOR 2.5 CI 1.4-4.4, immunocompromised (aOR 15.3 CI 1.8-127 and daily consumers of green salad (aOR 2.9 CI 1.2-7.2. Contact with animals (pets/farm animals and exposure to surface water (swimming/water sports were not associated with symptomatic disease. Conclusions A substantial proportion of Giardia lamblia cases in Germany are indigenously

  8. Effective treatment of common variable immunodeficiency associated diarrhea Diarrea asociada a inmunodeficiencia común variable tratada con budesonida

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    H. Córdova Guevara

    2009-03-01

    Full Text Available Common variable immunodeficiency disorder (CVID, the commonest symptomatic primary antibody deficiency syndrome, is characterised by recurrent bacterial infections, particularly of the upper and lower airways; it is also associated with an increased incidence of autoimmune and neoplastic disorders. CVID has a high prevalence of infectious, inflammatory and neoplastic gastrointestinal diseases. Up to 60% of the patients with non-treated CVID develop diarrhea and 10% associated idiopathic malabsorption with weight loss. The case of a 50-year-old woman with CVID-associated diarrhea, abdominal pain and bloating of one year's duration is reported. An exhaustive evaluation made for secondary causes of her symptoms was unrevealing; she was treated with loperamide and diet, without improvement. She later followed a course of oral budesonide for 3 months; her clinical symptoms disappeared and her quality of life improved. In conclusion, we report the case of a patient with CVID-related chronic diarrhea who responded well to oral budesonide treatment. This outcome provides the gastroenterologist with a new therapeutic option in this difficult group of patients.La inmunodeficiencia común variable (IDCV es la deficiencia primaria de anticuerpos sintomática más frecuente y está caracterizada por infecciones bacterianas recurrentes, especialmente de las vías aéreas superiores e inferiores, y también asociada a incremento de enfermedades autoinmunes y neoplasias. Presenta alta prevalencia de enfermedades gastrointestinales infecciosas, inflamatorias y neoplásicas. Hasta el 60% de los pacientes con IDCV no tratados desarrollan diarrea y el 10% desarrollan malabsorción idiopática asociado a pérdida de peso. Presentamos el caso de una mujer de 50 años con IDCV que presenta diarrea crónica, con dolor y distensión abdominal desde hace 1 año. Realizándose múltiples exploraciones y descartando causas secundarias de diarrea crónica, se inicia

  9. Gastroesophageal junction adenocarcinoma. A case report Adenocarcinoma de la unión gastroesofágica. Presentación de un caso

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    Nelia Maria Quintana Garcia

    2010-12-01

    Full Text Available The case of a 68 years old patient, smoking since adolescence, with urban origins, obesity history and gastroesophageal reflux symptoms is presented. The patient was diagnosed with gastroesophageal junction adenocarcinoma type III in the Gastroenterology Department of the Provincial University Hospital of Cienfuegos where he arrived with weight loss of about 20 pounds in four months along with dyspeptic manifestations such as stomach acidity, slow digestion, bloating and epigastric pain unrelated to food consumption. No dysphagia was observed as presentation form of the disease. The patient underwent surgery and chemotherapy and has had a favourable outcome up until today. It was decided to publish this article because of the few cases of gastroesophageal junction adenocarcinoma and especially type III that are commonly presented and also because the diagnosis is, unlike this case, usually made at an advanced stage of the diseaseSe presenta el caso de un paciente de 68 años, fumador desde la adolescencia, de procedencia urbana, con antecedentes personales de obesidad y síntomas de reflujo gastroesofágico, al que se le diagnosticó adenocarcinoma de la unión esofagogástrica tipo III, en el Servicio de Gastroenterología del Hospital Provincial Universitario de Cienfuegos, al cual acudió por presentar pérdida de peso de aproximadamente 20 libras en cuatro meses, acompañado de manifestaciones dispépticas: acidez, digestiones lentas, distensión abdominal y epigastralgia no relacionada con la ingestión de alimentos. No manifestó disfagia como forma de presentación de la enfermedad. Fue sometido a tratamiento quirúrgico y quimioterapia y ha tenido una evolución favorable hasta la fecha. Se decidió publicar este artículo debido a la baja frecuencia de presentación del adenocarcinoma de la unión esofagogástrica y en especial el tipo III, así como porque su diagnóstico generalmente se realiza en una etapa avanzada, a diferencia de

  10. Milk protein IgG and IgA: The association with milk-induced gastrointestinal symptoms in adults

    Institute of Scientific and Technical Information of China (English)

    Sari Anthoni; Erkki Savilahti; Hilpi Rautelin; Kaija-Leena Kolho

    2009-01-01

    AIM: To study the association between serum levels of milk protein IgG and IgA antibodies and milk-related gastrointestinal symptoms in adults.METHODS: Milk protein IgG and IgA antibodies were determined in serum samples of 400 subjects from five outpatient clinics in Southern Finland. Subjects were randomly selected from a total of 1900 adultsundergoing laboratory investigations in primary care. All 400 participants had completed a questionnaire onabdominal symptoms and dairy consumption while waiting for the laboratory visit. The questionnairecovered the nature and frequency of gastrointestinal problems, the provoking food items, family history and allergies. Twelve serum samples were disqualified due to insufficient amount of sera. The levels of specific milkprotein IgG and IgA were measured by using the ELISA technique. The association of the milk protein-specific antibody level was studied in relation to the milk-related gastrointestinal symptoms and dairy consumption.RESULTS: Subjects drinking milk ( n = 265) had higher levels of milk protein IgG in their sera than non-milk drinkers ( n = 123, P < 0.001). Subjects with gastrointestinal problems related to milk drinking ( n = 119) consumed less milk but had higher milk protein IgG levels than those with no milk-related gastrointestinal symptoms ( n = 198, P = 0.02). Among the symptomatic subjects, those reporting dyspeptic symptoms had lower milk protein IgG levels than non-dyspeptics ( P < 0.05). However, dyspepsia was not associated with milk drinking ( P = 0.5). The association of high milk protein IgG levels with constipation was close to the level of statistical significance. Diarrhea had no association with milk protein IgG level ( P = 0.5). With regard to minor symptoms, flatulence and bloating ( P = 0.8), were not associated with milk protein IgG level. Milk protein IgA levels did not show any association with milk drinking or abdominal symptoms. The levels of milk protein IgA and IgG declined as the

  11. Comparison of coconut water and a carbohydrate-electrolyte sport drink on measures of hydration and physical performance in exercise-trained men

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    Kalman Douglas S

    2012-01-01

    Full Text Available Abstract Background Sport drinks are ubiquitous within the recreational and competitive fitness and sporting world. Most are manufactured and artificially flavored carbohydrate-electrolyte beverages. Recently, attention has been given to coconut water, a natural alternative to manufactured sport drinks, with initial evidence indicating efficacy with regard to maintaining hydration. We compared coconut water and a carbohydrate-electrolyte sport drink on measures of hydration and physical performance in exercise-trained men. Methods Following a 60-minute bout of dehydrating treadmill exercise, 12 exercise-trained men (26.6 ± 5.7 yrs received bottled water (BW, pure coconut water (VitaCoco®: CW, coconut water from concentrate (CWC, or a carbohydrate-electrolyte sport drink (SD [a fluid amount based on body mass loss during the dehydrating exercise] on four occasions (separated by at least 5 days in a random order, single blind (subject and not investigators, cross-over design. Hydration status (body mass, fluid retention, plasma osmolality, urine specific gravity and performance (treadmill time to exhaustion; assessed after rehydration were determined during the recovery period. Subjective measures of thirst, bloatedness, refreshed, stomach upset, and tiredness were also determined using a 5-point visual analog scale. Results Subjects lost approximately 1.7 kg (~2% of body mass during the dehydrating exercise and regained this amount in a relatively similar manner following consumption of all conditions. No differences were noted between coconut water (CW or CWC and SD for any measures of fluid retention (p > 0.05. Regarding exercise performance, no significant difference (p > 0.05 was noted between BW (11.9 ± 5.9 min, CW (12.3 ± 5.8 min, CWC (11.9 ± 6.0 min, and SD (12.8 ± 4.9 min. In general, subjects reported feeling more bloated and experienced greater stomach upset with the CW and CWC conditions. Conclusion All tested beverages are

  12. Nursing of congenital microtia auricular reconstruction after the center of negative pressure drainage%先天性小耳畸形全耳廓再造术后中心负压引流的护理

    Institute of Scientific and Technical Information of China (English)

    曾沥缘; 王红霞

    2014-01-01

    目的:探讨先天性小耳畸形一次性耳再造术后持续中心负压引流的护理。方法选择2013年1月至2014年6月第三军医大学西南医院整形科收治的108例小耳畸形耳再造手术患者,在耳舟、三角窝处留置中心负压引流管持续中心负压吸引7天,记录术后每日负压引力及引流量,并观察耳区皮瓣情况及再造耳形态的变化。结果除4例患者再造耳外形略臃肿,其余患者对再造耳均表示满意。结论此方法操作简单,便于观察,对于提高再造耳的塑形效果及皮瓣的存活非常有效。%Objective To investigate the nursing of congenital microtia disposable ear reconstruction after operation durative center negative pressure drainage. Methods Select 2013 January to 2014 June orthopedic department of Southwest Hospital of Third Military Medical University from 108 patients with microtia reconstruction operation patients, in the scapha, triangular fossa indwelling central negative pressure drainage tube for central vacuum aspiration in 7 days after operation, record daily negative pressure attraction and drainage, and observe the changes and reconstruction flap ear morphology the. Results Except for 4 cases of reconstructed ear shape slightly bloated, the rest of the patients were satisfied with the reconstructed ear. Conclusion This method has the advantages of simple operation, convenient observation, is very effective for shaping effect and improve the survival of the flap reconstructed ear.

  13. Intoxicação por antibióticos ionóforos em animais Ionophore poisoning in animals

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    Vivian Assunção Nogueira

    2009-03-01

    Full Text Available O uso terapêutico de antibióticos ionóforos em medicina veterinária difundiu-se muito nos últimos anos, com conseqüente aumento no risco de intoxicação em animais. Antibióticos ionóforos são usados como coccidiostáticos e como aditivo em alimentos para animais, com o propósito de estimular o desenvolvimento e o ganho de peso. Os ionóforos mais utilizados na alimentação de animais são a monensina, lasalocida, nasarina e salinomicina. Há uma grande variação na susceptibilidade dos efeitos tóxicos dos ionóforos de acordo com a espécie animal. A intoxicação pode ocorrer quando dosagens elevadas de ionóforos são adicionadas aos alimentos, ou quando ionóforos são incluídos inadvertidamente ou acidentalmente em dosagens não corretas para determinada espécie animal. Casos de intoxicação têm sido descritos em bovinos, ovinos, suínos, eqüinos, cães e aves. Para os eqüinos os ionóforos são extremamente tóxicos. São considerados seguros quando usados nas espécies-alvo, dentro das dosagens recomendadas pelo fabricante.The therapeutic use of ionophores in veterinary medicine has grown in the last years, with resultant increase in the risk of poisoning in animals. Ionophores are used as food additives as coccidiostacts in several animal species and growth promoter and bloat prevention in ruminants. The most often used ionophores are monensin, lasalocid, narasin and salinomycin. There is a great variation in the susceptibility to the toxic effect of ionophores in different animal species. Poisoning can occur when the dosage is too high or when not correct doses for a certain animal species are given. Cases of poisoning have been described in sheep, swine, horses, dogs and poultry. For horses ionophores are extremely toxic. The use of ionophores is only safe when used accordingly to the instructions of the manufacturer and especially for each animal species. In this paper the most important data regarding clinical

  14. Effects of first-dose volume and exercise on the efficacy and tolerability of bowel preparations for colonoscopy in Chinese people

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    Qin Y

    2016-04-01

    Full Text Available Ying Qin, Wei Liu, Songbai Lin, Xiangfeng Li International Medical Services, Peking Union Medical College Hospital, Beijing, People’s Republic of China Aim: This study was designed to compare the efficacy and tolerability of bowel preparations with and without the higher first-dose volume of polyethylene glycol (PEG solution or exercise after drinking PEG solution in Chinese people. Methods: A total of 330 participants who had a colonoscopy done in Peking Union Medical College Hospital were randomly and evenly assigned to three groups. Participants in Group A ingested 1 L PEG solution and then ingested 2 L PEG solution at a rate of 250 mL every 15 minutes. Participants in Group B ingested 3 L PEG solution at a rate of 250 mL every 15 minutes and then exercised more than 10 minutes after ingesting each liter of PEG solution. Participants in Group C ingested 3 L PEG solution at a rate of 250 mL every 15 minutes. Experienced gastrointestinal endoscopists rated the efficacy of bowel preparations based on the Boston Bowel Preparation Scale score. A questionnaire regarding participants’ symptoms associated with bowel preparations was administered to evaluate participants’ tolerability. Results: The three groups had insignificant difference in the percentages of participants’ symptoms including dizziness, nausea, stomach ache, bloating, and asthenia. However, the percentages of participants having hunger sensation, sleep disturbance, and anal discomfort were significantly higher in groups with the higher first-dose volume of PEG solution or exercise after drinking PEG solution than without them. The three groups had insignificant difference in the Boston Bowel Preparation Scale score. Conclusion: Whether to add the higher first-dose volume of PEG solution and exercise after drinking PEG solution or not, all participants achieved a similar quality of bowel preparations. Bowel preparations without the additional first-dose volume of PEG

  15. Psychometric validation of patient-reported outcome measures assessing chronic constipation

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    Nelson LM

    2014-09-01

    Full Text Available Lauren M Nelson,1 Valerie SL Williams,1 Sheri E Fehnel,1 Robyn T Carson,2 James MacDougall,3 Mollie J Baird,3 Stavros Tourkodimitris,2 Caroline B Kurtz,3 Jeffrey M Johnston31RTI Health Solutions, Durham, NC, USA; 2Forest Research Institute, Jersey City, NJ, USA; 3Ironwood Pharmaceuticals, Cambridge, MA, USABackground: Measures assessing treatment outcomes in previous CC clinical trials have not met the requirements described in the US Food and Drug Administration's guidance on patient-reported outcomes.Aim: Psychometric analyses using data from one Phase IIb study and two Phase III trials of linaclotide for the treatment of chronic constipation (CC were conducted to document the measurement properties of patient-reported CC Symptom Severity Measures.Study methods: Each study had a multicenter, randomized, double-blind, placebo-controlled, parallel-group design, comparing placebo to four doses of oral linaclotide taken once daily for 4 weeks in the Phase IIb dose-ranging study (n=307 and to two doses of linaclotide taken once daily for 12 weeks in the Phase III trials (n=1,272. The CC Symptom Severity Measures addressing bowel function (Bowel Movement Frequency, Stool Consistency, Straining and abdominal symptoms (Bloating, Abdominal Discomfort, Abdominal Pain were administered daily using interactive voice-response system technology. Intraclass correlations, Pearson correlations, factor analyses, F-tests, and effect sizes were computed.Results: The CC Symptom Severity Measures demonstrated satisfactory test–retest reliability and construct validity. Factor analyses indicated one factor for abdominal symptoms and another for bowel symptoms. Known-groups F-tests substantiated the discriminating ability of the CC Symptom Severity Measures. Responsiveness statistics were moderate to strong, indicating that these measures are capable of detecting change.Conclusion: In large studies of CC patients, linaclotide significantly improved abdominal and

  16. Effect of the consumption of a fermented dairy product containing Bifidobacterium lactis DN-173 010 on constipation in childhood: a multicentre randomised controlled trial (NTRTC: 1571

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    Perrin Catherine

    2009-03-01

    Full Text Available Abstract Background Constipation is a frustrating symptom affecting 3% of children worldwide. Randomised controlled trials show that both polyethylene glycol and lactulose are effective in increasing defecation frequency in children with constipation. However, in 30–50%, these children reported abdominal pain, bloating, flatulence, diarrhoea, nausea and bad taste of the medication. Two recent studies have shown that the fermented dairy product containing Bifidobacterium lactis strain DN-173 010 is effective in increasing stool frequency in constipation-predominant irritable bowel syndrome patients with a defecation frequency Methods/design It is a two nation (The Netherlands and Poland double-blind, placebo-controlled randomised multicentre trial in which 160 constipated children (age 3–16 years with a defecation frequency Bifidobacterium lactis DN-173 010 or a control product, twice a day, for 3 weeks. During the study all children are instructed to try to defecate on the toilet for 5–10 minutes after each meal (3 times a day and daily complete a standardized bowel diary. Primary endpoint is stool frequency. Secondary endpoints are stool consistency, faecal incontinence frequency, pain during defecation, digestive symptoms (abdominal pain, flatulence, adverse effects (nausea, diarrhoea, bad taste and intake of rescue medication (Bisacodyl. Rate of success and rate of responders are also evaluated, with success defined as ≥ 3 bowel movements per week and ≤1 faecal incontinence episode over the last 2 weeks of product consumption and responder defined as a subject reporting a stool frequency ≥ 3 on the last week of product consumption. To demonstrate that the success percentage in the intervention group will be 35% and the success percentage in the control group (acidified milk without ferments, toilet training, bowel diary will be 15%, with alpha 0.05 and power 80%, a total sample size of 160 patients was calculated. Conclusion This

  17. WASP-South transiting exoplanets: WASP-130b, WASP-131b, WASP-132b, WASP-139b, WASP-140b, WASP-141b and WASP-142b

    Science.gov (United States)

    Hellier, C.; Anderson, D. R.; Cameron, A. Collier; Delrez, L.; Gillon, M.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Neveu-VanMalle, M.; Pepe, F.; Pollacco, D.; Queloz, D.; Ségransan, D.; Smalley, B.; Southworth, J.; Triaud, A. H. M. J.; Udry, S.; Wagg, T.; West, R. G.

    2017-03-01

    We describe seven exoplanets transiting stars of brightness V = 10.1-12.4. WASP-130b is a 'warm Jupiter' having an orbital period of 11.6 d around a metal-rich G6 star. Its mass and radius (1.23 ± 0.04 MJup and 0.89 ± 0.03 RJup) support the trend that warm Jupiters have smaller radii than hot Jupiters. WASP-131b is a bloated Saturn-mass planet (0.27 MJup and 1.22 RJup). Its large scaleheight and bright (V = 10.1) host star make it a good target for atmospheric characterization. WASP-132b (0.41 MJup and 0.87 RJup) is among the least irradiated and coolest of WASP planets, having a 7.1-d orbit around a K4 star. WASP-139b is a 'super-Neptune' akin to HATS-7b and HATS-8b, being the lowest mass planet yet found by WASP (0.12 MJup and 0.80 RJup). The metal-rich K0 host star appears to be anomalously dense, akin to HAT-P-11. WASP-140b is a 2.4-MJup planet in an eccentric (e = 0.047 ± 0.004) 2.2-d orbit. The planet's radius is large (1.4 RJup), but uncertain owing to the grazing transit (b = 0.93). The 10.4-d rotation period of the K0 host star suggests a young age, and the time-scale for tidal circularization is likely to be the lowest of all known eccentric hot Jupiters. WASP-141b (2.7 MJup, 1.2 RJup and P = 3.3 d) and WASP-142b (0.84 MJup, 1.53 RJup and P = 2.1 d) are typical hot Jupiters orbiting metal-rich F stars. We show that the period distribution within the hot-Jupiter bulge does not depend on the metallicity of the host star.

  18. Hepatic Angiosarcoma: a Review of Twelve Cases

    Institute of Scientific and Technical Information of China (English)

    Qiang Li; Xishan Hao

    2005-01-01

    OBJECTIVE Hepatic angiosarcoma (HAS), a lethal disease, is the most common sarcoma arising in the liver. Little information about the epidemiology, etiology, diagnosis and management of HAS has been reported. Increased familiarity with this disease will facilitate correct diagnosis and help to improve management of this condition in the future.The objective of this study was to describe cases of hepatic angiosarcoma and to discuss the etiologic, diagnostic, therapeutic features and prognosis of this tumor. This report not only serves to give more evidence of the relationship between hepatic angiosarcoma and carcinogenic exposure, but also demonstrates the key points in different methods of diagnosis and the optimal treatment of hepatic angiosarcoma.METHODS Twelve cases of hepatic angiosareoma were analyzed retrospectively, representing the different character in clinical presentations and laboratory computed tomographical scans; pathological data and treatment are described. Clinical and biologic follow-up was carried out for two years after surgical treatment.RESULTS There were nine men and three women varying in ages from 57 to 71 years with an average of 64.3 years. Ten patientshad a history of exposure to vinyl chloride or thorotrast. Mild or moderate abdominal pain and bloating, abdominal mass and fever were the common clinical presentations. Tumors were visualized by ultrasonography and CT scans in all patients. Biochemical profiles yielded variable results and proved to be of little value in detection or diagnosis. Surgical resection was feasible for each patient who was treated as follows: two wedge resections, six segementectomies and four bisegmentectomies. Five patients received Neoadjuvant chemotherapy postoperatively. The survival rate of those cases was poor. The maximum survival time was fourteen months. The mean survival time for this chemotherapeutic group was 11 months. The difference between the survival time of those treated with an operation

  19. Atmospheric Downscaling using Genetic Programming

    Science.gov (United States)

    Zerenner, Tanja; Venema, Victor; Simmer, Clemens

    2013-04-01

    optimization as genetic operators. Next we have worked on an improvement of the downscaling rule for the two-meter-temperature. We have added an if-function with four input arguments to the function set. Since this has shown to increase bloat we have additionally modified our fitness function by including penalty terms for both the size of the solutions and the number intron nodes, i.e program parts that are never evaluated. Starting from the known downscaling rule for the two-meter temperature, which linearly exploits the orography anomalies allowed or disallowed by a certain temperature gradient, our GP system has been able to find an improvement. The rule produced by the GP clearly shows a better performance concerning the reproduced small-scale variability.

  20. Rapid Characterization of Molecular Chemistry, Nutrient Make-Up and Microlocation of Internal Seed Tissue

    Energy Technology Data Exchange (ETDEWEB)

    Yu,P.; Block, H.; Niu, Z.; Doiron, K.

    2007-01-01

    Wheat differs from corn in biodegradation kinetics and fermentation characteristics. Wheat exhibits a relatively high rate (23% h{sup 01}) and extent (78% DM) of biodegradation, which can lead to metabolic problems such as acidosis and bloat in ruminants. The objective of this study was to rapidly characterize the molecular chemistry of the internal structure of wheat (cv. AC Barrie) and reveal both its structural chemical make-up and nutrient component matrix by analyzing the intensity and spatial distribution of molecular functional groups within the intact seed using advanced synchrotron-powered Fourier transform infrared (FTIR) microspectroscopy. The experiment was performed at the U2B station of the National Synchrotron Light Source at Brookhaven National Laboratory, New York, USA. The wheat tissue was imaged systematically from the pericarp, seed coat, aleurone layer and endosperm under the peaks at {approx}1732 (carbonyl C{double_bond}O ester), 1515 (aromatic compound of lignin), 1650 (amide I), 1025 (non-structural CHO), 1550 (amide II), 1246 (cellulosic material), 1160, 1150, 1080, 930, 860 (all CHO), 3350 (OH and NH stretching), 2928 (CH{sub 2} stretching band) and 2885 cm{sup -1} (CH{sub 3} stretching band). Hierarchical cluster analysis and principal component analysis were applied to analyze the molecular FTIR spectra obtained from the different inherent structures within the intact wheat tissues. The results showed that, with synchrotron-powered FTIR microspectroscopy, images of the molecular chemistry of wheat could be generated at an ultra-spatial resolution. The features of aromatic lignin, structural and non-structural carbohydrates, as well as nutrient make-up and interactions in the seeds, could be revealed. Both principal component analysis and hierarchical cluster analysis methods are conclusive in showing that they can discriminate and classify the different inherent structures within the seed tissue. The wheat exhibited distinguishable

  1. Advances in clinical research of celiac disease%乳糜泻临床研究进展

    Institute of Scientific and Technical Information of China (English)

    李慕然; 刘艳迫; 李文

    2011-01-01

    Celiac disease (CD) is a type of primary malab-sorption syndrome characterized by gluten intolerance and intestinal mucosal lesions. When genetically susceptible persons eat food containing gluten, their immune system responds by damaging or destroying intestinal villi to result in intestinal malnutrition. Depending on the degree of malabsorption, the symptoms of CD vary among individuals, ranging from no symptoms, few or mild symptoms, to many or severe symptoms. Some common symptoms of CD are diarrhea, abdominal pain and bloating. People with the disease may have other symptoms outside the digestive tract. Blood marker tests and small intestinal biopsy can help make a clear diagnosis. The disease is common in North Europe, North America and Australia, but is rarely reported in China. In this article, we will review the prevalence, pathogenesis, clinical manifestations, diagnosis and treatment of CD.%乳糜泻(celiac disease,CD)是患者对麸质不耐受引起小肠黏膜病变为特征的一种原发性吸收不良综合征.当遗传易感者食用含有麸质的食物后,引起机体的免疫应答,破坏小肠绒毛,引起小肠吸收不良.依据吸收不良的程度,CD的症状有个体差异,有的无症状或症状轻微,有的症状较重.典型表现为腹泻、腹痛、腹胀等消化系症状,也有的患者出现消化系外症状.血清标志物检测和小肠活检组织病理可明确诊断.此病在北美、北欧、澳大利亚发病率较高,在我国报道少见.本文就CD的流行病学、发病机制、临床表现以及诊断和治疗作一综述.

  2. Splenic vascular surgical intervention combined wti hf ast track surgery in spleen trau ma%脾脏血管介入联合加速康复外科理念在脾脏创伤中的运用

    Institute of Scientific and Technical Information of China (English)

    刘兴东; 蒋延美; 赖景奎; 杨波; 刘洪; 罗友琛

    2016-01-01

    Objective:To evaluate the feasibility of splenic vascular surgical intervention combined with fast track surgery for treatment of patients with traumatic rupture.Methods:The control group of 15 patients was diagnosed as traumatic rupture underwent conventional DAS splenic artery embolization therapy, FST group 15 cases where the concept of joint fast track surgery, postoperative observation time eating, bloating, abdominal pain time, flatus, length of stay, hospital costs.Results:30 cases were successfully retained spleen, eating earlier, relatively rapid postoperative recovery, including four cases of postoperative fever.Conclusion:DSA splenic artery embolization retention should be a simple, small damage, joint with FST patients related to the concept of eating time early, rapid recovery, pain relief, relative safety, reduce hospital costs, might have some clinical value.%目的:探讨应用血管介入联合加速康复外科理念( Fast track surgery,FST)救治外伤性脾破裂患者的可行性。方法:对照组15例诊断为外伤性脾破裂患者行常规DAS脾动脉栓塞止血治疗,FST组15例联合加速康复外科理念救治,观察患者术后进食时间,腹胀腹痛缓解时间,肛门排气时间,住院时间,住院费用。结果:30例均保留脾脏成功,进食时间早,术后恢复相对较快,其中4例出现术后发热。结论:DSA血管介入栓塞保留脾脏是一种简单,损伤小,联合加速康复外科相关理念患者术后进食时间早,康复快,疼痛减轻,相对安全,住院费用降低,具有一定临床价值。

  3. Maastricht Ⅱ treatment scheme and efficacy of different proton pump inhibitors in eradicating Helicobacter pylori

    Institute of Scientific and Technical Information of China (English)

    Engin Altintas; Orhan Sezgin; Oguz Ulu; Ozlem Aydin; Handan Camdeviren

    2004-01-01

    AIM: The Maastricht Ⅱ criteria suggest the use of amoxicillin and clarithromycin in addition to a proton pump inhibitor over 7-10 d as a first line therapy in the eradication of Helicobacter pylori(H pylori). For each proton pump inhibitor, various rates of eradication have been reported. The present study was to compare the efficacy of different proton pump inhibitors like omeprazole, lansoprazole and pantoprazole in combination with amoxicillin and clarithromycin in the first line eradication of H pylori and to investigate the success of H pylori eradication in our district.METHODS: A total of 139 patients were included having a Helicobacter pylori(+) gastroduodenal disorders diagnosed by means of histology and urease test. Besides amoxicillin (1 000 mg twice a day) and clarithromycin (500 mg twice a day), they were randomized to take omeprazole (20 mg twice a day), or lansoprazole (30 mg twice a day), or pantoprozole (40 mg twice a day) for 14 d. Four weeks after the therapy, the eradication was assessed by means of histology and urease test. It was evaluated as eradicated if the H pylori was found negative in both. The complaints (pain in epigastrium, nocturnal pain, pyrosis and bloating)were graded in accordance with the Licert scale. The compliance of the patients was recorded.RESULTS: The eradication was found to be 40.8% in the omeprazole group, 43.5% in the lansoprazole group and 47.4% in the pantoprazole group. Sixty-three out of 139patients (45%) had eradication. No statistically significant difference was observed between the groups. Significant improvements were seen in terms of the impact on the symptom scores in each group.CONCLUSION: There was no difference between omeprazole, lansoprazole and pantoprazole in H pylori eradication, and the rate of eradication was as low as 45%.Symptoms were improved independent of the eradication in each treatment group. The iow eradication rates suggest that the antibiotic resistance or the genetic differences of

  4. Scintigraphic evaluation of gastric emptying and motility; Nuklearmedizinische Diagnostik der Magenmotilitaet

    Energy Technology Data Exchange (ETDEWEB)

    Linke, R. [Klinik und Poliklinik fuer Nuklearmedizin, Ludwig-Maximilians-Univ. Muenchen (Germany)

    2003-06-01

    The stomach consists of two functionally distinct parts. The fundus and upper corpus mainly serve as a reservoir and exert primarily a tonic activity, which presses ingesta towards the antrum and duodenum. The phasic contractility of the lower corpus and antrum cause mechanical breakdown and mixing of the food particels. A complex regulation of these mechanisms provides a regular gastric emptying. Various disorders such as diabetes mellitus, mixed connective tissue diseases, gastritis, tumors, dyspeptic disorders but also drugs and gastric surgery may influence or impair gastric function and may cause typical symptoms such as upper abdominal discomfort, bloating, nausea and vomiting. However, the interpretation of gastrointestinal symptoms often is difficult. Radionuclide studies of gastric emptying and motility are the most physiologic tools available for studying gastric motor function. Gastric scintigraphy is non-invasive, uses physiologic meal and is quantitative. Emptying curves generated from the gastric ROI offer information whether a disorder is accompanied by a regular, fast or slow gastric emptying. Data on gastric contractions (amplitude and frequency) provide additional information to results obtained by conventional emptying studies. Depending on the underlying disorder, gastric emptying and peristalsis showed both corresponding and discrepant findings. Therefore, both parameters should be routinely assessed to further improve characterisation of gastric dysfunction by scintigraphy. (orig.) [German] Proximaler und distaler Magen haben funktionell unterschiedliche Aufgaben. Waehrend der proximale Magen die Nahrung voruebergehend speichert und ueber die Generierung eines gastroduodenalen Druckgefaelles eine fraktionierte Entleerung in den Duenndarm bewirkt, dient die Peristaltik des distalen Magens der Durchmischung und Zerkleinerung des Speisebreis. Eine komplexe hormonelle, humorale und nervale Regulation dieser ineinandergreifenden Funktionen

  5. Gastric Emptying in Patients with Diabetes: Gastric Emptying Time, Retention Rate and Effect of Cisapride

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Byung Chun; Choi, Chung Il; Gwak, Dong Suck; Lee, Jae Tae; Lee, Kyu Bo; Kim, Bo Wan; Chung, Jun Mo [Kyungpook National University School of Medicine, Daegu (Korea, Republic of)

    1992-07-15

    Gastic emptying scan in diabetic patients is widely used to assess the degree of motility disturbance and the symptoms such as nausea, vomiting, bloating, abdominal pain and early gastric fullness which we can't find anatomic lesion by fiberoscopic or barium study. In order to determine the relationship among diabetic gastropathy, neropathy, retinopathy and disease duration, gastric emptying scan using {sup 99m}Tc-tin colloid labeled scramble egg in hamburger was performed in 10 healthy male controls and 50 diabetic patients which were subdivided to no neuropathy, peripheral neuropathy and autonomic neuropathy groups according to the degree of diabetic neuropathy and no retinopathy, background retinopathy and proliferative retinopathy groups according to the degree of diabetic retinopathy. After medication of cisapride for 2 weeks, we observed the presence of improvement of gastric motility in diabetics. The results were as following: 1) In controls, gastric emptying time (GET1/2) was 75 +- 13.6 min and 2 hour gastric retension rate(GRR2) was 32 +- 11.1%. 2) In diabetics, GET/2 was prolonged more than 2 hours and GRR2 was 58 +- 23.1%. According to degree of neuropathy, GET1/2 was prolonged more than 2 hours in all three groups and GRR2 was 54+- 24.1% in no neuropathy group, 57 +- 24.3% in peripheral neuropathy group and 69 +- 24.6% in autonomic neuropathy group. According to degree of retinopathy, GET1/2 was 110 +- 23.4 min in no retinopathy group and prolonged more than 2 hours in other two groups and GRR2 was 45 +- 21.6% in no retinopathy group, 71 +- 19.7% in background retinopathy group and 73 +- 21.5% in proliferative retinopathy group. 3) After cisapride for 2 weeks, GET1/2 and GRR2 were improved as 90 +- 14.6 min and 40 +- 13.8% (initial GET1/2 and GRR2 were above 2 hours and 61 +- 15.4%). We can conclude from above findings that gastropathy in diabetic neuropathy suggesting main underlying factor in motility disorder. The degree of retinopathy and

  6. Lead telluride with increased mechanical stability for cylindrical thermoelectric generators; Bleitellurid mit erhoehter mechanischer Stabilitaet fuer zylindrische thermoelektrische Generatoren

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Andreas

    2013-04-30

    The aim of this work is to improve the mechanical stability of lead telluride (PbTe), trying to vary its mechanical properties independently from its thermoelectric properties. Thus the influence of material preparation as well as different dopants on the mechanical and thermoelectric properties of lead telluride is being analysed. When using appropriately set process parameters, milling and sintering of lead telluride increases the material's hardness. With sintering temperatures exceeding 300 C stable material of high relative density can be achieved. Milling lead telluride generates lattice defects leading to a reduction of the material's charge carrier density. These defects can be reduced by increased sintering temperatures. Contamination of the powder due to the milling process leads to bloating during thermal cycling and thus reduced density of the sintered material. In addition to that, evaporation of tellurium at elevated temperatures causes instability of the material's thermoelectric properties. Based on the experimental results obtained in this work, the best thermoelectric and mechanical properties can be obtained by sintering coarse powders at around 400 C. Within this work a concept was developed to vary the mechanical properties of lead telluride via synthesis of PbTe with electrically nondoping elements, which thus may keep the thermoelectric properties unchanged. Therefore, the mechanical and thermoelectric properties of Pb{sub 1-x}Ca{sub x}Te were investigated. Doping pure PbTe with calcium causes a significant increase of the material's hardness while only slightly decreasing the charge carrier density and thus keeping the thermoelectric properties apart from a slight reduction of the electrical conductivity nearly unchanged. The abovementioned concept is proven using sodium doped lead telluride, as it is used for thermoelectric generators: The additional doping with calcium again increases the material's hardness while

  7. The unexpected truth about dates and hypoglycemia

    Directory of Open Access Journals (Sweden)

    Mohammed I Yasawy

    2016-01-01

    Full Text Available Background: Dates are a concentrated source of essential nutrients, vitamins, minerals, and carbohydrates (CHOs, which are necessary for the maintenance of optimum health. Most of the CHOs in dates come from sugars including glucose and fructose. Dates are commonly consumed in Saudi Arabia, particularly at the time of breaking the fast to provide instant energy and maintain blood sugar level. However, dates may cause hypoglycemia in a rare condition named as heredity fructose intolerance (HFI, and a few families have been to see us with a history of that nature. This is to report the preliminary results of an on-going study of a group of patients who get symptoms of hypoglycemia following the ingestion of dates and have suffered for years without an accurate diagnosis. Methodology: This report is based on three patients, from the same family, living in a date growing region of the Kingdom of Saudi Arabia (KSA. The patients had been to several medical centers without getting any definite answers or diagnosis until they were referred to the Gastroenterology Clinic of King Fahd Hospital of the University, Al-Khobar, KSA. The data were obtained by careful history and laboratory investigations, and a final diagnosis of HFI made on fructose intolerance test (FIT. Results: The patients reported that they had avoided eating dates because of various symptoms, such as bloating, nausea, and even hypoglycemia when larger amounts were consumed. Their other symptoms included sleepiness, sweating, and shivering. After full examinations and necessary laboratory tests based on the above symptoms, FIT was performed and the patients were diagnosed with HFI. They were referred to a dietitian who advised a fructose-free diet. They felt well and were free of symptoms. Conclusion: HFI may remain undiagnosed until adulthood and may lead to disastrous complications and even death. The diagnosis can only be suspected after a careful dietary history is taken supported by

  8. [Sulpiride: study of 669 patient presenting with pain of psychological origin].

    Science.gov (United States)

    Ferreri, M; Florent, C; Gerard, D

    2000-01-01

    Among somatoform disorders, pain disorder (DSM IV) appears to be relatively common in general practice and to cause social, psychological, and functional impairment. A previous study conducted by Lemoine (1997) has shown that sulpiride is more effective than placebo in reducing intensity and frequency of pain in this disorder. The aim of our study was to assess safety and efficacy of sulpiride in a large sample of patients under natural conditions of use, in general practice. In a multicenter, open clinical trial, 669 patients (mean age: 47 years +/- 12; male: 245, female: 424) fulfilling the DSM IV criteria for pain disorder (of gastrointestinal localization), were included by 321 general practitioners (GP) and treated for 6 weeks with sulpiride 150 mg/d. Investigators' evaluations were planned at D14 and D42. Furthermore a diary was given to each patient for self evaluation and intercurrent events reporting. The pain was of psychological type in 93% of cases and caused social or working disabilities in 78% of patients. At inclusion the mean score of the Hamilton Anxiety Rating Scale was 18 +/- 8, and the mean score of the depression scale HARD (Humeur, Angoisse, Ralentissement, Danger) was 14.8 +/- 6.4. During the study 7.9% of the patients had at least one adverse event, and 3% of patients were withdrawn for adverse event. Safety assessed with a specific variable (grouping together adverse events' reporting and results of CGI item 3) was good for 88% of patients. The principal criterion of efficacy was the clinician's evaluation of the intensity and frequency of abdominal pain on a four-point scale from 0 (asymptomatic) to 3 (important/continuous) from D0 to D End a decrease in pain intensity (91% of patients) and in pain frequency (89%) was observed as well as in frequency and intensity of related gastroenterological symptoms such as disturbances of bowel movements (79% and 78%), bloated symptoms (88% and 83%), nausea/vomiting (90% and 90%). A similar

  9. Phenomena during thermal removal of binders

    Science.gov (United States)

    Hrdina, Kenneth Edward

    The research presented herein has focused on debinding of an ethylene copolymer from a SiC based molded ceramic green body. Examination of the binder burnout process was carried out by breaking down the process into two distinct regions: those events which occur before any weight loss begins, and those events occurring during binder removal. Below the temperature of observed binder loss (175sp°C), both reversible and irreversible displacement was observed to occur. The displacement was accounted for by relaxation of molding stresses, thermal expansion of the system, and melting of the semicrystalline copolymer occurring during heating. Upon further heating the binder undergoes a two stage thermal degradation process. In the first stage, acetic acid is the only degradation product formed, as determined by GC/MS analysis. In this stage, component shrinkage persisted and it was found that one unit volume of shrinkage corresponded with one unit volume of binder removed, indicating that no porosity developed. The escaping acetic acid effluents must diffuse through liquid polymer filled porous regions to escape. The gas pressure of the acetic acid species produced in the first stage of the thermal degradation may exceed the ambient pressure promoting bubble formation. Controlling the heating rate of the specimen maintains the gas pressure below the bubbling threshold and minimizes the degradation time. Experiments have determined the kinetics of the reaction in the presence of the high surface area (10-15msp2/g) ceramic powder and then verified that acetic acid was diffusing through the polymer phase to the specimen surface where evaporation is taking place. The sorption method measured the diffusivity and activity of acetic acid within the filled ceramic system within a TGA. These data were incorporated into a Fickian type model which included the rate of generation of the diffusing species. The modeling process involved prediction of the bloating temperature as a

  10. Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial

    Directory of Open Access Journals (Sweden)

    Yardley Lucy

    2010-11-01

    Full Text Available Abstract Background IBS affects 10-22% of the UK population. Abdominal pain, bloating and altered bowel habit affect quality of life, social functioning and time off work. Current GP treatment relies on a positive diagnosis, reassurance, lifestyle advice and drug therapies, but many suffer ongoing symptoms. A recent Cochrane review highlighted the lack of research evidence for IBS drugs. Neither GPs, nor patients have good evidence to inform prescribing decisions. However, IBS drugs are widely used: In 2005 the NHS costs were nearly £10 million for mebeverine and over £8 million for fibre-based bulking agents. CBT and self-management can be helpful, but poor availability in the NHS restricts their use. We have developed a web-based CBT self-management programme, Regul8, based on an existing evidence based self-management manual and in partnership with patients. This could increase access with minimal increased costs. Methods/Design The aim is to undertake a feasibility factorial RCT to assess the effectiveness of the commonly prescribed medications in UK general practice for IBS: mebeverine (anti-spasmodic and methylcellulose (bulking-agent and Regul8, the CBT based self-management website. 135 patients aged 16 to 60 years with IBS symptoms fulfilling Rome III criteria, recruited via GP practices, will be randomised to 1 of 3 levels of the drug condition: mebeverine, methylcellulose or placebo for 6 weeks and to 1 of 3 levels of the website condition, Regul8 with a nurse telephone session and email support, Regul8 with minimal email support, or no website, thus creating 9 groups. Outcomes: Irritable bowel symptom severity scale and IBS-QOL will be measured at baseline, 6 and 12 weeks as the primary outcomes. An intention to treat analysis will be undertaken by ANCOVA for a factorial trial. Discussion This pilot will provide valuable information for a larger trial. Determining the effectiveness of commonly used drug treatments will help

  11. Clinical potential of naloxegol in the management of opioid-induced bowel dysfunction

    Directory of Open Access Journals (Sweden)

    Poulsen JL

    2014-09-01

    Full Text Available Jakob Lykke Poulsen,1 Christina Brock,1,2 Anne Estrup Olesen,1,2 Matias Nilsson,1 Asbjørn Mohr Drewes1,3 1Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; 2Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark; 3Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkAbstract: Opioid-induced bowel dysfunction (OIBD is a burdensome condition which limits the therapeutic benefit of analgesia. It affects the entire gastrointestinal tract, predominantly by activating opioid receptors in the enteric nervous system, resulting in a wide range of symptoms, such as reflux, bloating, abdominal cramping, hard, dry stools, and incomplete evacuation. The majority of studies evaluating OIBD focus on constipation experienced in approximately 60% of patients. Nevertheless, other presentations of OIBD seem to be equally frequent. Furthermore, laxative treatment is often insufficient, which in many patients results in decreased quality of life and discontinuation of opioid treatment. Novel mechanism-based pharmacological approaches targeting the gastrointestinal opioid receptors have been marketed recently and even more are in the pipeline. One strategy is prolonged release formulation of the opioid antagonist naloxone (which has limited systemic absorption and oxycodone in a combined tablet. Another approach is peripherally acting, µ-opioid receptor antagonists (PAMORAs that selectively target µ-opioid receptors in the gastrointestinal tract. However, in Europe the only PAMORA approved for OIBD is the subcutaneously administered methylnaltrexone. Alvimopan is an oral PAMORA, but only approved in the US for postoperative ileus in hospitalized patients. Finally, naloxegol is a novel, oral PAMORA expected to be approved soon. In this review, the prevalence and pathophysiology of OIBD is presented. As PAMORAs seem to be a promising approach, their potential

  12. Nutritional support research progress? of COPD patients with mechanical ventilation%COPD机械通气患者营养支持研究进展

    Institute of Scientific and Technical Information of China (English)

    孙丽娟; 信丽艳; 薛森海; 赵长海

    2012-01-01

    慢性阻塞性肺疾病(COPD)的患者由于疾病本身的影响造成营养素的摄入不足、吸收不良及消耗量增加等,易导致机体的营养不良.良好的营养状态对COPD患者的预后有着积极的作用,而合理的营养支持有助于改善患者的营养不良状态.在营养支持过程中,营养支持方式及时机的选择、营养配方的选择以及一些特殊营养物质的添加都会直接影响营养治疗的效果.同时,在进行营养治疗过程中,易出现腹胀、腹泻、胃潴留、返流、吸入性肺炎等常见并发症,这些并发症如何处理也会影响患者的预后.营养支持的监测可以为营养治疗方案的调整提供依据,因此应该如何通过相关生化指标的监测来评估营养支持的效果也是一个重要的问题.作者对这些相关问题作一讨论.%Due to inadequate nutrient intake , malabsorption and increased consumption caused by Chronic obstructive pulmonary disease (COPD) , the COPD patients are easy to be malnutrition. Good nutritional status plays positive role in prognosis of COPD patients, and reasonable nutritional support also helps to improve the state of the patient s malnutrition. In the nutrition support process, the choice of nutritional support mode and opportunity, the choice of the nutritional formula, as well as some special nutrients added will directly affect the nutritional treatment effect. Meanwhile, during the nutrition therapy process, bloating , diarrhea , gastric retention , regurgitation , aspiration pneumonia and other common complications are prone to appear and the following treatments will affect the patients prognosis. Monitoring of nutritional support can provide the basis for the adjustment of the nutritional treatment program. Therefore, how to evaluate the effect of nutritional support via monitoring of biochemical markers is an important issue. This article discusses the above issues.

  13. The effect of environment on development and survival of pupae of the necrophagous fly Ophyra albuquerquei Lopes (Diptera, Muscidae

    Directory of Open Access Journals (Sweden)

    Rodrigo Ferreira Krüger

    2011-09-01

    Full Text Available The effect of environment on development and survival of pupae of the necrophagous fly Ophyra albuquerquei Lopes (Diptera, Muscidae. Species of Ophyra Robineau-Desvoidy, 1830 are found in decomposing bodies, usually in fresh, bloated and decay stages. Ophyra albuquerquei Lopes, for example, can be found in animal carcasses. The influence of environmental factors has not been evaluated in puparia of O. albuquerquei. Thus, the focus of this work was motivated by the need for models to predict the development of a necrophagous insect as a function of abiotic factors. Colonies of O. albuquerquei were maintained in the laboratory to obtain pupae. On the tenth day of each month 200 pupae, divided equally into 10 glass jars, were exposed to the environment and checked daily for adult emergence of each sample. We concluded that the high survival rate observed suggested that the diets used for rearing the larvae and maintaining the adults were appropriate. Also, the data adjusted to robust generalized linear models and there were no interruptions of O. albuquerquei pupae development within the limits of temperatures studied in southern Rio Grande do Sul, given the high survival presented.Efeito de fatores ambientais sobre o desenvolvimento e sobrevivência de pupas de Ophyra albuquerquei Lopes (Diptera, Muscidae. Espécies de Ophyra Robineau-Desvoidy, 1830 são encontradas em corpos em decomposição, usualmente nas fases fresca, inchamento e murcha. Entre estas espécies, Ophyra albuquerquei Lopes, 1985 pode ser encontrada em carcaças de ratos e coelhos. A influência de fatores ambientais sobre pupas de O. albuquerquei não tinha sido avaliada até o momento. Desta maneira, o foco deste trabalho foi motivado pela necessidade por modelos de previsão do desenvolvimento de insetos necrófagos em função de fatores abióticos. Colônias de O. albuquerquei foram mantidas em laboratório para a obtenção de pupas. Até o décimo dia de cada mês, 200

  14. A Real Shooting Star

    Science.gov (United States)

    2007-01-01

    [figure removed for brevity, see original site] Click on the image for movie of A Real Shooting Star This artist's animation illustrates a star flying through our galaxy at supersonic speeds, leaving a 13-light-year-long trail of glowing material in its wake. The star, named Mira (pronounced my-rah) after the latin word for 'wonderful,' sheds material that will be recycled into new stars, planets and possibly even life. NASA's Galaxy Evolution Explorer discovered the long trail of material behind Mira during its survey of the entire sky in ultraviolet light. The animation begins by showing a close-up of Mira -- a red-giant star near the end of its life. Red giants are red in color and extremely bloated; for example, if a red giant were to replace our sun, it would engulf everything out to the orbit of Mars. They constantly blow off gas and dust in the form of stellar winds, supplying the galaxy with molecules, such as oxygen and carbon, that will make their way into new solar systems. Our sun will mature into a red giant in about 5 billion years. As the animation pulls out, we can see the enormous trail of material deposited behind Mira as it hurls along between the stars. Like a boat traveling through water, a bow shock, or build up of gas, forms ahead of the star in the direction of its motion. Gas in the bow shock is heated and then mixes with the cool hydrogen gas in the wind that is blowing off Mira. This heated hydrogen gas then flows around behind the star, forming a turbulent wake. Why does the trailing hydrogen gas glow in ultraviolet light? When it is heated, it transitions into a higher-energy state, which then loses energy by emitting ultraviolet light - a process known as fluorescence. Finally, the artist's rendering gives way to the actual ultraviolet image taken by the Galaxy Evolution Explorer Mira is located 350 light-years from Earth in the constellation Cetus, otherwise known as the whale. Coincidentally, Mira and its 'whale of a tail' can be

  15. CLINIC EFFECT OF MEMBRANE ELEMENTS IN TREATMENT OF COMPOUND STOMACH ULCER%消化性溃疡的复方胃膜素治疗效果分析

    Institute of Scientific and Technical Information of China (English)

    李建

    2011-01-01

    [目的]研究复方胃膜素治疗消化性溃疡的效果.[方法]将我院2010年住院的64例HP阴性消化性溃疡患者随机分为两组,分别采用复方胃膜素和胃膜素治疗,比较两组治疗6周后的主观感受症状、治疗效果及不良反应有无差异.[结果]复方胃膜素组患者喛气、腹胀、上腹痛和有症状的发生率均低于胃膜素组,P<0.05;溃疡的总有效率显著商于胃膜素组,X2=4.27,P=0.039;不良反应显著低于胃膜素组X2=4.95,P=0.026.[结论]复方胃膜素在胃膜素基础上添加了碳酸钙、碳酸镁、次碳酸铋和维生素U,与胃膜素相比,对消化性溃疡的治疗效果更好,不良反应发生率更低,值得临床推广应用.%[Objective] To study the treatment effect of compound gastric mucin on peptic ulcer. [Methods] 64 patients who hospitalized in 2010 were randomly divided into two groups, and respectively got compound gastric mucin and gastric mucin. We compared the subjective feelings, treatment effects and side effects of two groups after treating six weeks. [Results] The incidence rate of belching, bloating, upper abdominal pain and persons with symptoms in compound gastric mucin group were significantly lower than gastric mucin group (P< 0.05) ; The effective rate was significantly higher than that of the gastric mucin group, x2 = 4.27, P= 0.039; The side effects were significantly lower than gastric mucin group, x2 = 4.95, P= 0.026. [Conclusion] Based on the gastric mucin, the compound gastric mucin was added with calcium carbonate, magnesium carbonate, bismuth sub-carbonate and vitamin U. Compared to gastric mucin, compound gastric mucin is better to cure peptic ulcer, with lower side effect, and is worth for clinical use.

  16. Clinical observation on the effects of diet on health quality%药膳对健康质量影响的临床观察

    Institute of Scientific and Technical Information of China (English)

    魏宝永; 郑斯玉; 曹术东; 王晓霞; 陈宾

    2016-01-01

    Objective: Diet, sleep and stool situation were important indicators of the quality of health. In real life, large numbers of people were perplexed by health problems, especially the longer course. However, many factors make people difficult to adhere to treatment. In the paper, compliance problems of patients were elaborated. Methods: Recipes with good efficacy and good taste were selected, processed into a powder or small particles, and added the right amount of cereal to produce food, to treat insomnia, anorexia, constipation and diarrhea. Results: For neuropsychiatric symptoms of insomnia, dreams, upset, difculty falling asleep, the total efciency was 93.39%; For dysfunctional system of clinical symptoms of bloating, belching, anorexia, epigastric noisy discomfort or pain, poor appetite eat less, the total efciency was 90.09%; the total efciency of constipation was 92.68%; the total efciency of diarrhea, loose stools was 92.98%.%目的:饮食、睡眠和二便状况是健康质量的重要标志。现实生活中有大量人群存在健康质量问题,且病程较长,长期困扰其身心健康。但诸多因素使之难以坚持治疗,本法旨在解决患者的依从问题。方法:选择既有治疗作用,又口感尚好的药膳配方,加工成粉状或细小颗粒,加入适量谷物,做成食品,以食代药,治疗失眠、纳差、便秘、泄泻。结果:治疗以精神、神经症状为主的失眠、多梦、心烦意乱、入睡困难,总有效率为93.39%;治疗化系统功能失调临床症状:腹胀、嗳气、纳差,胃脘嘈杂不适或疼痛,纳呆食少,总有效率为90.09%;治疗便秘,总有效率为92.68%;治疗腹泻、便溏,总有效率为92.98%。

  17. Treatment of functional dyspepsia with Changweishu capsule%肠胃舒胶囊治疗功能性消化不良51例疗效观察

    Institute of Scientific and Technical Information of China (English)

    祁永玲; 赵志娟

    2011-01-01

    目的 观察肠胃舒胶囊治疗功能性消化不良(FD)的临床疗效.方法 将102例FD患者随机分为2组.治疗组51例予肠胃舒胶囊治疗,对照组51例予枸橼酸莫沙必利片治疗,2组疗程均为4周.观察2组临床疗效和主要临床症状的改善情况.结果 治疗组总有效率96.08%,对照组总有效率82.35%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组.治疗组主要症状上腹胀、上腹痛、厌食、早饱、嗳气、恶心和呕吐改善率均高于对照组(P<0.05).结论 肠胃舒胶囊对FD有良好的治疗作用,疗效优于西药枸橼酸莫沙必利片.%Objective To investigate the effect of functional dyspepsia treated with Changweishu capsule.Methods 102 patients with functional dyspepsia were randomly divided into two groups. Patients in treatment group(n =51 ) were treated by Changweishu capsule. Patients in control group were treated by Mosapride citrate tablets. The course was four weeks in two groups. The clinical effect and improvement of main clinical symptoms were observed.Results The total effective rate in treatment group(96.08% ) was higher than that in control group (82.35%, P <0.05). The improvement rate of key symptoms of bloating, abdominal pain, anorexia, early satiety, belching, nausea and vomiting in treatment group were higher than those in control group( P < 0.05). Conclusion Changweishu capsule has a good effect on functional dyspepsia, the effect was more than that of Mosapride citrate tablets.

  18. Diagnostic and Therapeutic Strategies of Gastric Motility Disorder in Different Stages of Diabetes%不同阶段糖尿病胃运动障碍诊治对策

    Institute of Scientific and Technical Information of China (English)

    蓝宇; 路国涛

    2012-01-01

    Gastric motility disorder is common in patients with diabetes. The cardinal symptoms include bloating, early satiety, epigastric discomfort, nausea, vomiting and delayed gastric emptying. Delayed gastric emptying affects pharmacokinetics of hypoglycemic agents, causes mismatch of peak postprandial blood glucose level and peak concentration of insulin and oral hypoglycemic agents, thereby affects glycemic control. There are different patterns of gastric motility disorder in different stages of diabetes. The most commonly used diagnostic method for gastric emptying is scintigraphic measurement. Treatment of gastric motility disorder in diabetes includes dietary modifications and prokinetic agents to ameliorate symptoms and improve glycemic control. Therapeutic approaches of gastroparesis include gastric electrical stimulation, endoscopic pyloric injection of botulinum toxin A, endoscopic placement of nasal-jejunum nutrient feeding tube and percutaneous endoscopic gastrostomy/jejunostomy and surgical therapy.%糖尿病患者常见胃运动障碍,表现为上腹胀、早饱、上腹不适、恶心、呕吐等症状以及胃排空延迟,胃排空延迟影响降血糖药的药代动力学,造成餐后血糖升高与降血糖药或胰岛素的血浓度高峰不匹配,进而影响血糖的控制与稳定.糖尿病不同阶段胃运动障碍表现形式不同.核素法是最常用的胃排空诊断方法.糖尿病胃运动障碍的处理包括饮食调节、促动力药以减轻症状、控制血糖,针对胃轻瘫的治疗包括胃电刺激、内镜下幽门注射肉毒杆菌毒素A、内镜下放置鼻胃空肠营养管或经皮内镜下胃(空肠)造瘘、外科手术等.

  19. 食管贲门癌术后胃瘫32例临床诊治体会%Thoughts on diagnosis and treatment of 32 cases of post-surgery subtotal gastroparesis on gastrectomy and esophagectomy can-cer patients

    Institute of Scientific and Technical Information of China (English)

    陶一勤; 李道航; 沙纪名; 胡海峰

    2009-01-01

    Objective To review the diagnosis and treatment of gastroparesis after esophagectomy. Methods Retrospectively ana-lyzed 32 cases of clinical data between 1991 and 2007 with post-surgery subtotal Gastroparesis on gastrectomy & esophagectomy patients. Re-sults Gastroparesis in these patients caused the undesirable symptoms of nausea, vomiting, abdominal pain, bloating and early satiety and there is lcase of death due to Pseudomonas aeruginosa pneumonia. The upper gastrointestinal radiography showed a decrease in gastric motility, and no stomach obstruction. The rest of the cases had curative effects through the reduction of gastric pressure, maintenance of hydro electrolytic bal-ance and nutritional supplement, and application of prokinetic drugs. Conclusion The diagnosis of gastroparesis mainly depends on the clini-cal appearances, chest CT Scan and GI. When the gastroparesis is confirmed, the patient should be treated with conservative methods, such as the application of internal nutrition, prokinetic agents.%目的 总结食管、贲门癌术后胃瘫临床诊治经验.方法 对1991年至2007年食管癌、贲门癌术后发生胃瘫的32例患者的治疗过程和效果进行回顾性分析.结果 所有患者主要表现为胃潴留,无明显腹痛,肛门排气大多正常.消化道造影可见胃蠕动差,吻合口通畅.CT显示胸腔胃明显增大以及大量胃液潴留.本组病例中1例患者死于绿脓杆菌性肺炎.其余所有病例经胃肠减压,肠内营养支持,维持水电解质平衡,以及用促进胃肠动力药物的应用等措施使病情均得以缓解出院.结论 食管癌、贲门癌术后胃瘫的诊断主要依据临床表现、消化道造影及胸CT等检查.排除机械性梗阻的存在后应积极采取肠内营养及胃肠动力促进剂等综合治疗,可以治愈.

  20. Research progress on vegetable tannins and its effect on animals%植物单宁及其对动物的作用研究进展

    Institute of Scientific and Technical Information of China (English)

    王妍君; 谢开云; 赵祥; 董宽虎

    2011-01-01

    This article summarized the content of vegetable tannins,the impact of tannins on plants and ani reals, and the approaches to reduce the content of tannins. Vegetable tannins are common polyphenolic in plants and it is self-protective substances derived from the carbohydrate metabolism in plant evolution. There are two types of tannins in vascular plants, hydrolysis tannin and condensed tannin. The content of vegetable tannins is concerned with genes,location, growth stage, and diseases of plant. The impacts of tannins on animals are in many aspects, high content tannins can protect the plant from herbivore and appropriate content tannins can re- duce animal bloat. There are many ways to reduce the content of vegetable tannins.%对植物中单宁含量、单宁对动植物的影响及降低单宁含量的方法进行了综述。植物单宁是广泛存在于植物体内的一类多元酚化舍物,是植物进化过程中由碳水化舍物代谢衍生出来的一种自身保护性物质。一般认为单宁在维管植物中有两种存在形式既水解单宁和缩合单宁。单宁的含量与基因、部位、植物生长阶段、植物病虫害等有关;植物含有高度单宁可保护植物不被采食,适当浓度单宁可减少动物胃胀气,因此,对动物的影响有利有弊;可以通过多种方法来降低植物中单宁的含量。

  1. Clinical and epidemiological perspectives of dyspepsia in a multiracial Malaysian population.

    Science.gov (United States)

    Goh, Khean-Lee

    2011-04-01

    Dyspepsia is perhaps the most common gastrointestinal disease universally. The prevalence of dyspepsia ranges from 7-40% in population based studies worldwide. These figures vary with definition of dyspepsia used and also with the survey methodology. As with Western studies, functional dyspepsia (FD) predominates in Asia. With a decline in peptic ulcer disease and gastric cancer, the proportion of FD is set to increase further. Studies have shown FD to account for 50-70% of cases of uninvestigated dyspepsia. In Malaysia dyspepsia has been reported in up to 15% of a rural and 25% of an urban population. No racial differences were seen in the rural survey. In the urban survey, Malays and Indians were found to have significantly more dyspepsia than Chinese. No clear explanation can be found for these racial differences. In clinical practice, Malays seem to complain a lot of wind and bloating in the "stomach." This is interesting to note when you compare it with the prevalence of H. pylori which is distinctly less common amongst Malays compared to the Indians and Chinese. As with many Asian populations, many Malaysians do not consult for complains of dyspepsia. Many will self medicate and others may even bear with their complains. This is probably true in the rural population. Traditional medications are often used and these are often ethnic based. Different types of lotions for example are used for massaging the putative area in the abdomen by Malay, Chinese and Indian patients. Moxibustion and acupuncture is still practiced by Chinese traditional physicians for treatment of dyspepsia. The notion that mood disorders may underlies dyspepsia is still poorly accepted by a less educated or rural population who consider a psychiatric consultation a taboo. Amongst urban dwellers where Westernized medical care is readily available and the awareness of potential serious disease like cancer is higher, consultation for dyspepsia is certainly higher. Indeed a higher education

  2. [Laparoscopic surgery of gastroesophageal reflux in children].

    Science.gov (United States)

    Dias, Ana; Amaral, Marina; Trindade, Eunice; Dias, Jorge Amil; Campos, Miguel; Estevão-Costa, José

    2013-01-01

    Introdução: O refluxo gastroesofágico na criança é frequente e geralmente inócuo. Contudo, perante doença de refluxo gastroesofágico pode impor-se o tratamento cirúrgico, o qual pode ser realizado por via clássica ou laparoscópica. No presente estudo pretende-se avaliar a exequibilidade, eficácia e segurança da cirurgia antirrefluxo (fundoplicatura de Nissen) por via laparoscópica com ênfase no recém-nascido, lactente e primeira infância.Material e Métodos: Estudaram-se as crianças com refluxo gastroesofágico propostas para cirurgia por via laparoscópica entre janeiro 2006 e dezembro 2012 num Serviço de Cirurgia Pediátrica de um Hospital universitário. Realizou-se uma análise descritiva e comparativa por faixa etária (grupo I: 3 anos) e presença de comorbilidades. Foram avaliados os seguintes parâmetros: demografia, sintomatologia, comorbilidades, indicações operatórias, perioperatório e evolução pós-operatória. Foi assumido um nível de significância de 5%.Resultados: Foram propostas 55 crianças, das quais 12 do grupo I, 15 do grupo II e 28 do grupo III. 50,9% apresentavam comorbilidades (21 com doença do sistema nervoso central e sete com atresia esofágica). Em 52 (94,5%) casos, a cirurgia foi exequível exclusivamente por via laparoscópica. A duração do procedimento foi de 167 ± 42 minutos, sem diferenças significativas entre grupos etários, mas superior na doença do sistema nervoso central. Com um seguimento de 35,5 ± 23,9 meses, ocorreram as seguintes complicações: síndrome de gas-bloat, dumping e disfagia em oito casos (15,7%) e hérniaparaesofágica em dois casos (3,9%), sem diferenças significativas entre os grupos; verificou-se recidiva clínica com reoperação em dois casos.Conclusão: A fundoplicatura de Nissen laparoscópica é um procedimento exequível, eficaz e com baixa morbilidade, inclusive em recém-nascidos, lactentes e na primeira infância.

  3. Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study.

    Science.gov (United States)

    Childs, Caroline E; Röytiö, Henna; Alhoniemi, Esa; Fekete, Agnes A; Forssten, Sofia D; Hudjec, Natasa; Lim, Ying Ni; Steger, Cara J; Yaqoob, Parveen; Tuohy, Kieran M; Rastall, Robert A; Ouwehand, Arthur C; Gibson, Glenn R

    2014-06-14

    Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic (Bifidobacterium animalis subsp. lactis Bi-07, 109 colony-forming units (CFU)/d) or synbiotic (8 g XOS+109 CFU Bi-07/d) was given to healthy adults (25-65 years) for 21 d. The aim was to identify the effect of the supplements on bowel habits, self-reported mood, composition of the gut microbiota, blood lipid concentrations and immune function. XOS supplementation increased mean bowel movements per d (P= 0·009), but did not alter the symptoms of bloating, abdominal pain or flatulence or the incidence of any reported adverse events compared with maltodextrin supplementation. XOS supplementation significantly increased participant-reported vitality (P= 0·003) and happiness (P= 0·034). Lowest reported use of analgesics was observed during the XOS+Bi-07 supplementation period (P= 0·004). XOS supplementation significantly increased faecal bifidobacterial counts (P= 0·008) and fasting plasma HDL concentrations (P= 0·005). Bi-07 supplementation significantly increased faecal B. lactis content (P= 0·007), lowered lipopolysaccharide-stimulated IL-4 secretion in whole-blood cultures (P= 0·035) and salivary IgA content (P= 0·040) and increased IL-6 secretion (P= 0·009). XOS supplementation resulted in lower expression of CD16/56 on natural killer T cells (P= 0·027) and lower IL-10 secretion (P= 0·049), while XOS and Bi-07 supplementation reduced the expression of CD19 on B cells (XOS × Bi-07, P= 0·009). The present study demonstrates that XOS induce bifidogenesis, improve aspects of the plasma lipid profile and modulate the markers of immune function in healthy adults. The provision of XOS+Bi-07 as a synbiotic may confer further benefits due to the discrete effects of Bi-07 on the gut

  4. Comparing the rehydration potential of different milk-based drinks to a carbohydrate-electrolyte beverage.

    Science.gov (United States)

    Desbrow, Ben; Jansen, Sarah; Barrett, Abby; Leveritt, Michael D; Irwin, Christopher

    2014-12-01

    The aim of this study was to compare the rehydration potential of a carbohydrate-electrolyte beverage with several varieties of milk following exercise-induced fluid losses. Fifteen male participants (age 24.9 ± 5.5 years, height 179.3 ± 4.9 cm, body mass 75.8 ± 6.6 kg (mean ± SD)) lost 2.0% ± 0.2% body mass through intermittent cycling before consuming a different beverage on 4 separate occasions. Drinks included cow's milk (286 kJ·100 mL(-1)), soy milk (273 kJ·100 mL(-1)), a milk-based liquid meal supplement (Sustagen Sport (Nestle); 417 kJ·100 mL(-1)), and a sports drink (Powerade (Coca Cola Ltd); 129 kJ·100 mL(-1)). Beverages were consumed over 1 h in volumes equivalent to 150% of body mass loss. Body mass, blood and urine samples, and measures of gastrointestinal tolerance were obtained before and hourly for 4 h after beverage consumption. Net body mass at the conclusion of each trial was significantly less with Powerade (-1.37 ± 0.3 kg) than with cow's milk (-0.92 ± 0.48 kg), soy milk (-0.78 ± 0.37 kg), and Sustagen Sport (-0.48 ± 0.39 kg). Net body mass was also significantly greater for Sustagen Sport compared with cow's milk trials, but not soy milk. Upon completion of trials, the percentage of beverage retained was Sustagen Sport 65.1% ± 14.7%, soy milk 46.9% ± 19.9%, cow's milk 40.0% ± 24.9%, and Powerade 16.6% ± 16.5%. Changes in plasma volume and electrolytes were unaffected by drink treatment. Subjective ratings of bloating and fullness were higher during all milk trials compared with Powerade whereas ratings of overall thirst were not different between beverages. Milk-based drinks are more effective rehydration options compared with traditional sports drinks. The additional energy, protein, and sodium in a milk-based liquid meal supplement facilitate superior fluid recovery following exercise.

  5. Single Step to Orbit; a First Step in a Cooperative Space Exploration Initiative

    Science.gov (United States)

    Lusignan, Bruce; Sivalingam, Shivan

    1999-01-01

    At the end of the Cold War, disarmament planners included a recommendation to ease reduction of the U.S. and Russian aerospace industries by creating cooperative scientific pursuits. The idea was not new, having earlier been suggested by Eisenhower and Khrushchev to reduce the pressure of the "Military Industrial Complex" by undertaking joint space exploration. The Space Exploration Initiative (SEI) proposed at the end of the Cold War by President Bush and Premier Gorbachev was another attempt to ease the disarmament process by giving the bloated war industries something better to do. The engineering talent and the space rockets could be used for peaceful pursuits, notably for going back to the Moon and then on to Mars with human exploration and settlement. At the beginning of this process in 1992 staff of the Stanford Center for International Cooperation in Space attended the International Space University in Canada, met with Russian participants and invited a Russian team to work with us on a joint Stanford-Russian Mars Exploration Study. A CIA student and Airforce and Navy students just happened to join the Stanford course the next year and all students were aware that the leader of the four Russian engineers was well versed in Russian security. But, as long as they did their homework, they were welcome to participate with other students in defining the Mars mission and the three engineers they sent were excellent. At the end of this study we were invited to give a briefing to Dr. Edward Teller at Stanford's Hoover Institution of War and Peace. We were also encouraged to hold a press conference on Capitol Hill to introduce the study to the world. At a pre-conference briefing at the Space Council, we were asked to please remind the press that President Bush had asked for a cooperative exploration proposal not a U.S. alone initiative. The Stanford-Russian study used Russia's Energia launchers, priced at $300 Million each. The mission totaled out to $71.5 Billion

  6. Review of Dercum’s disease and proposal of diagnostic criteria, diagnostic methods, classification and management

    Directory of Open Access Journals (Sweden)

    Hansson Emma

    2012-04-01

    Full Text Available Abstract Definition and clinical picture We propose the minimal definition of Dercum’s disease to be generalised overweight or obesity in combination with painful adipose tissue. The associated symptoms in Dercum’s disease include fatty deposits, easy bruisability, sleep disturbances, impaired memory, depression, difficulty concentrating, anxiety, rapid heartbeat, shortness of breath, diabetes, bloating, constipation, fatigue, weakness and joint aches. Classification We suggest that Dercum’s disease is classified into: I. Generalised diffuse form A form with diffusely widespread painful adipose tissue without clear lipomas, II. Generalised nodular form - a form with general pain in adipose tissue and intense pain in and around multiple lipomas, and III. Localised nodular form - a form with pain in and around multiple lipomas IV. Juxtaarticular form - a form with solitary deposits of excess fat for example at the medial aspect of the knee. Epidemiology Dercum’s disease most commonly appears between the ages of 35 and 50 years and is five to thirty times more common in women than in men. The prevalence of Dercum’s disease has not yet been exactly established. Aetiology Proposed, but unconfirmed aetiologies include: nervous system dysfunction, mechanical pressure on nerves, adipose tissue dysfunction and trauma. Diagnosis and diagnostic methods Diagnosis is based on clinical criteria and should be made by systematic physical examination and thorough exclusion of differential diagnoses. Advisably, the diagnosis should be made by a physician with a broad experience of patients with painful conditions and knowledge of family medicine, internal medicine or pain management. The diagnosis should only be made when the differential diagnoses have been excluded. Differential diagnosis Differential diagnoses include: fibromyalgia, lipoedema, panniculitis, endocrine disorders, primary psychiatric disorders, multiple symmetric lipomatosis, familial

  7. Pancrelipase: an evidence-based review of its use for treating pancreatic exocrine insufficiency

    Directory of Open Access Journals (Sweden)

    Nakajima K

    2012-07-01

    Full Text Available Kei Nakajima,1 Haruki Oshida,1 Toshitaka Muneyuki,2 Masafumi Kakei21Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, 2First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Amanuma, Omiya, Saitama, JapanAbstract: Pancreatic exocrine insufficiency (PEI is often observed in patients with pancreatic diseases, including chronic pancreatitis, cystic fibrosis, and tumors, or after surgical resection. PEI often results in malnutrition, weight loss and steatorrhea, which together increase the risk of morbidity and mortality. Therefore, nutritional interventions, such as low-fat diets and pancreatic enzyme replacement therapy (PERT, are needed to improve the clinical symptoms, and to address the pathophysiology of pancreatic exocrine insufficiency. PERT with delayed-release pancrelipase is now becoming a standard therapy for pancreatic exocrine insufficiency because it significantly improves the coefficients of fat and nitrogen absorption as well as clinical symptoms, without serious treatment-emergent adverse events. The major adverse events were tolerable gastrointestinal tract symptoms, such as stomach pain, nausea, and bloating. Fibrosing colonopathy, a serious complication, is associated with high doses of enzymes. Several pancrelipase products have been approved by the US Food and Drug Administration in recent years. Although many double-blind, placebo-controlled trials of pancrelipase products have been conducted in recent years, these studies have enrolled relatively few patients and have often been less than a few weeks in duration. Moreover, few studies have addressed the issue of pancreatic diabetes, a type of diabetes that is characterized by frequent hypoglycemia, which is difficult to manage. In addition, it is unclear whether PERT improves morbidity and mortality in such settings. Therefore

  8. Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction

    Directory of Open Access Journals (Sweden)

    Leppert W

    2015-04-01

    Full Text Available Wojciech Leppert Chair and Department of Palliative Medicine, Poznan University of Medical Sciences, Poznan, Poland Abstract: Opioid-induced bowel dysfunction (OIBD comprises gastrointestinal (GI symptoms, including dry mouth, nausea, vomiting, gastric stasis, bloating, abdominal pain, and opioid-induced constipation, which significantly impair patients’ quality of life and may lead to undertreatment of pain. Traditional laxatives are often prescribed for OIBD symptoms, although they display limited efficacy and exert adverse effects. Other strategies include prokinetics and change of opioids or their administration route. However, these approaches do not address underlying causes of OIBD associated with opioid effects on mostly peripheral opioid receptors located in the GI tract. Targeted management of OIBD comprises purely peripherally acting opioid receptor antagonists and a combination of opioid receptor agonist and antagonist. Methylnaltrexone induces laxation in 50%–60% of patients with advanced diseases and OIBD who do not respond to traditional oral laxatives without inducing opioid withdrawal symptoms with similar response (45%–50% after an oral administration of naloxegol. A combination of prolonged-release oxycodone with prolonged-release naloxone (OXN in one tablet (a ratio of 2:1 provides analgesia with limited negative effect on the bowel function, as oxycodone displays high oral bioavailability and naloxone demonstrates local antagonist effect on opioid receptors in the GI tract and is totally inactivated in the liver. OXN in daily doses of up to 80 mg/40 mg provides equally effective analgesia with improved bowel function compared to oxycodone administered alone in patients with chronic non-malignant and cancer-related pain. OIBD is a common complication of long-term opioid therapy and may lead to quality of life deterioration and undertreatment of pain. Thus, a complex assessment and management that addresses underlying

  9. Integrin-linked kinase regulates oligodendrocyte cytoskeleton, growth cone, and adhesion dynamics.

    Science.gov (United States)

    Michalski, John-Paul; Cummings, Sarah E; O'Meara, Ryan W; Kothary, Rashmi

    2016-02-01

    Integrin-linked kinase (ILK), a focal adhesion protein, brokers the link between cytoskeleton, cell membrane, and extracellular environment. Here, we demonstrate a role for ILK in laminin-2-mediated adhesion in primary murine oligodendrocytes (OLs) - with ILK loss leading to severe defects in process branching and outgrowth. These defects were partially recovered when the ILK-depleted OLs were instead grown on the non-integrin-activating substrate poly-l-lysine. Intriguingly, ILK loss on the neutral poly-l-lysine substrate led to swelling at the tips of OL processes, which we identified as enlarged growth cones. Employing the bloated ILK-depleted growth cones as template, we demonstrate the appearance of distinct cytoskeletal domains within OL growth cones bearing classic neuronal growth cone architecture. Further, microtubule organization was severely perturbed following ILK loss, with centripetal microtubule looping and failure to bundle occurring in a laminin-2-independent manner. Together, our work highlights differences in specific aspects of OL biology as driven by laminin-2-dependent or independent ILK governed mechanisms. We also reinforce the idea of OLs as growth cone bearing cells and describe the neuronal-like cytoskeleton therein. Finally, we demonstrate a role for ILK in OL growth cone maturation through microtubule regulation, the loss of which translates to decreased process length and myelin production capacity. We describe herein how different substrates fundamentally alter the oligodendrocyte's response to loss of integrin-linked kinase (ILK). On laminin-2 (Ln-2), ILK-depleted oligodendrocytes appear stunted and malformed, while on the non-integrin-activating substrate PLL branching and membrane formation are restored. We also reinforce the idea of oligodendrocytes as growth cone-bearing cells, detailing the growth cone's cytoskeletal architecture. Strikingly, loss of ILK on poly-l-lysine leads to growth cone swelling, the structure's size and

  10. The small intestine and irritable bowel syndrome (IBS): a batch process model.

    Science.gov (United States)

    Dobson, Brian C

    2008-11-01

    Faults in a batch process model of the small intestine create the symptoms of all types of irritable bowel syndrome. The model has three sequential processing sections corresponding to the natural divisions of the intestine. It is governed by a brain controller that is divided into four sub-controllers, each with a unique neurotransmitter. Each section has a sub-controller to manage transport. Sensors in the walls of the intestine provide input and output goes to the muscles lining the walls of the intestine. The output controls the speed of the food soup, moves it in both directions, mixes it, controls absorption, and transfers it to the next section at the correct speed (slow). The fourth sub-controller manages the addition of chemicals. It obtains input from the first section of the process via the signalling hormone Cholecystokinin and sends output to the muscles that empty the gall bladder and pancreas. The correct amounts of bile salts and enzymes are then added to the first section. The sub-controllers produce output only when input is received. When output is missing the enteric nervous system applies a default condition. This default condition normally happens when no food is in the intestine. If food is in the intestine and a transport sub-controller fails to provide output then the default condition moves the food soup to the end of that section. The movement is in one direction only (forward), at a speed dependent on the amount and type of fibre present. Cereal, bean and vegetable fibre causes high speeds. This default high speed transport causes irritable bowel syndrome. A barrier is created when a section moving fast at the default speed, precedes a section controlled by a transport sub-controller. Then the sub-controller constricts the intestine to stop the fast flow. The barrier causes constipation, cramping, and bloating. Diarrhoea results when the section terminating the process moves at the fast default speed. Two problems can occur to prevent

  11. Inclusion of sainfoin (Onobrychis viciifolia) silage in dairy cow rations affects nutrient digestibility, nitrogen utilization, energy balance, and methane emissions.

    Science.gov (United States)

    Huyen, N T; Desrues, O; Alferink, S J J; Zandstra, T; Verstegen, M W A; Hendriks, W H; Pellikaan, W F

    2016-05-01

    Sainfoin (Onobrychis viciifolia) is a tanniniferous legume forage that has potential nutritional and health benefits preventing bloating, reducing nematode larval establishment, improving N utilization, and reducing greenhouse gas emissions. However, the use of sainfoin as a fodder crop in dairy cow rations in northwestern Europe is still relatively unknown. The objective of this study was to evaluate the effect of sainfoin silage on nutrient digestibility, animal performance, energy and N utilization, and CH4 production. Six rumen-cannulated, lactating dairy cows with a metabolic body weight (BW(0.75)) of 132.5±3.6kg were randomly assigned to either a control (CON) or a sainfoin (SAIN)-based diet over 2 experimental periods of 25 d each in a crossover design. The CON diet was a mixture of grass silage, corn silage, concentrate, and linseed. In the SAIN diet, 50% of grass silage dry matter (DM) of the CON diet was exchanged for sainfoin silage. The cows were adapted to 95% of ad libitum feed intake for a 21-d period before being housed in climate-controlled respiration chambers for 4 d, during which time feed intake, apparent total-tract digestibility, N and energy balance, and CH4 production was determined. Data were analyzed using a mixed model procedure. Total daily DM, organic matter, and neutral detergent fiber intake did not differ between the 2 diets. The apparent digestibility of DM, organic matter, neutral detergent fiber, and acid detergent fiber were, respectively, 5.7, 4.0, 15.7, and 14.8% lower for the SAIN diet. Methane production per kilogram of DM intake was lowest for the SAIN diet, CH4 production as a percentage of gross energy intake tended to be lower, and milk yield was greater for the SAIN diet. Nitrogen intake, N retention, and energy retained in body protein were greater for the SAIN than for the CON diet. Nitrogen retention as a percentage of N intake tended to be greater for the SAIN diet. These results suggest that inclusion of sainfoin

  12. Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy.

    Science.gov (United States)

    Iwamoto, Junichi; Saito, Yoshifumi; Honda, Akira; Matsuzaki, Yasushi

    2013-03-21

    Low-dose aspirin (LDA) is clinically used for the prevention of cardiovascular and cerebrovascular events with the advent of an aging society. On the other hand, a very low dose of aspirin (10 mg daily) decreases the gastric mucosal prostaglandin levels and causes significant gastric mucosal damage. The incidence of LDA-induced gastrointestinal mucosal injury and bleeding has increased. It has been noticed that the incidence of LDA-induced gastrointestinal hemorrhage has increased more than that of non-aspirin non-steroidal anti-inflammatory drug (NSAID)-induced lesions. The pathogenesis related to inhibition of cyclooxygenase (COX)-1 includes reduced mucosal flow, reduced mucus and bicarbonate secretion, and impaired platelet aggregation. The pathogenesis related to inhibition of COX-2 involves reduced angiogenesis and increased leukocyte adherence. The pathogenic mechanisms related to direct epithelial damage are acid back diffusion and impaired platelet aggregation. The factors associated with an increased risk of upper gastrointestinal (GI) complications in subjects taking LDA are aspirin dose, history of ulcer or upper GI bleeding, age > 70 years, concomitant use of non-aspirin NSAIDs including COX-2-selective NSAIDs, and Helicobacter pylori (H. pylori) infection. Moreover, no significant differences have been found between ulcer and non-ulcer groups in the frequency and severity of symptoms such as nausea, acid regurgitation, heartburn, and bloating. It has been shown that the ratios of ulcers located in the body, fundus and cardia are significantly higher in bleeding patients than the ratio of gastroduodenal ulcers in patients taking LDA. Proton pump inhibitors reduce the risk of developing gastric and duodenal ulcers. In contrast to NSAID-induced gastrointestinal ulcers, a well-tolerated histamine H2-receptor antagonist is reportedly effective in prevention of LDA-induced gastrointestinal ulcers. The eradication of H. pylori is equivalent to treatment with

  13. Review of Dercum’s disease and proposal of diagnostic criteria, diagnostic methods, classification and management

    Science.gov (United States)

    2012-01-01

    Definition and clinical picture We propose the minimal definition of Dercum’s disease to be generalised overweight or obesity in combination with painful adipose tissue. The associated symptoms in Dercum’s disease include fatty deposits, easy bruisability, sleep disturbances, impaired memory, depression, difficulty concentrating, anxiety, rapid heartbeat, shortness of breath, diabetes, bloating, constipation, fatigue, weakness and joint aches. Classification We suggest that Dercum’s disease is classified into: I. Generalised diffuse form A form with diffusely widespread painful adipose tissue without clear lipomas, II. Generalised nodular form - a form with general pain in adipose tissue and intense pain in and around multiple lipomas, and III. Localised nodular form - a form with pain in and around multiple lipomas IV. Juxtaarticular form - a form with solitary deposits of excess fat for example at the medial aspect of the knee. Epidemiology Dercum’s disease most commonly appears between the ages of 35 and 50 years and is five to thirty times more common in women than in men. The prevalence of Dercum’s disease has not yet been exactly established. Aetiology Proposed, but unconfirmed aetiologies include: nervous system dysfunction, mechanical pressure on nerves, adipose tissue dysfunction and trauma. Diagnosis and diagnostic methods Diagnosis is based on clinical criteria and should be made by systematic physical examination and thorough exclusion of differential diagnoses. Advisably, the diagnosis should be made by a physician with a broad experience of patients with painful conditions and knowledge of family medicine, internal medicine or pain management. The diagnosis should only be made when the differential diagnoses have been excluded. Differential diagnosis Differential diagnoses include: fibromyalgia, lipoedema, panniculitis, endocrine disorders, primary psychiatric disorders, multiple symmetric lipomatosis, familial multiple lipomatosis, and

  14. Effectofendogenoushypergastrinemiaon gallbladdervolumeandejectionfractionin patientswithautoimmunegastritis

    Institute of Scientific and Technical Information of China (English)

    Mustafa Yakut; Onur Keskin; Irfan Soykan

    2012-01-01

    BACKGROUND: Gastrin has a cholecystokinetic action on gallbladder motility, and cholecystokinin and gastrin act directly on the smooth muscle of the gallbladder. The aim of this study was to investigate the effect of endogenous hypergastrinemia on gallbladder motility in patients with autoimmune gastritis. METHODS: Forty-one patients (29 females, 12 males;mean age, 46 years) with autoimmune gastritis and 29 healthy subjects (17 females, 12 males;mean age, 44.8 years) were enrolled in the study. Fasting and postprandial gallbladder volumes were measured ultrasonographically with the ellipsoid technique and the ejection fraction of the gallbladder was calculated from fasting and postprandial volumes. All subjects were investigated after 12 hours of fasting and 30 minutes after a standard test meal. RESULTS: The gallbladder ejection fraction (%) of the patients with autoimmune gastritis was lower than that of the control group (46.06±18.28%vs 55.03±14.67%, P=0.032). There was no difference between patients with autoimmune gastritis and the control group in terms of the mean fasting gallbladder volume (30.38±12.85 vs 29.27±9.91 cm3, P=0.189) and the mean postprandial gallbladder volume (15.67±8.32 vs 13.44±7.69 cm3, P=0.258). Logistic regression analysis of baseline parameters revealed that"abdominal bloating"was a risk factor for the low gallbladder ejection fraction in autoimmune gastritis patients (P=0.045, F=4.40). In addition, logistic regression analysis of baseline parameters revealed that smoking (n=5, P=0.025, F=5.44) is a predictor of low gallbladder ejection fraction in patients with autoimmune gastritis. CONCLUSIONS: Patients with endogenous hypergastrinemia have a low gallbladder ejection fraction compared with healthy controls. This study shows that at least part of upper gastrointestinal symptoms observed in this patient population may be due to altered gallbladder motility.

  15. Combination therapy of azintamide and domperidone in functional dyspepsia: a randomised, double-blind, placebo-controlled trial%复方阿嗪米特肠溶片联合多潘立酮治疗功能性消化不良的随机、双盲、安慰剂对照临床研究

    Institute of Scientific and Technical Information of China (English)

    赵莉; 许乐; 李琪; 王秀娣; 王冬梅; 王昭钢

    2011-01-01

    Objective To study the efficacy and safety of combined therapy of compound azintamide and domperidone in functional dyspepsia. Methods A randomised, double-blind, placebo-controlled trial.Two hundred and eight patients with functional dyspepsia were randomly grouped into group A (experimental group, 102 cases) and group B (control group, 106 cases). The patients in the group A were given 2 tablets of compound azintamide 3 times a day in addition to domperidone 10 mg 3 times per day for four weeks. The patients in the group B were only given domperidone 10 mg 3 times per day for 4 weeks. The therapeutic efficacy was evaluated by modified Severity of Dyspepsia Assessment (mSODA) and Global Patient Assessment (GPA). Results Subscore in mSODA:the change of bloating/pain intensity score in group A is -12.35±5.48 while group B is -10.52±4.65(P=0.009), the change of non-bloating/pain symptoms score in group A is -5.75±3.31 while group B is - 4. 86 ± 2.65 (P=0.033), and the change of satisfaction score in group A is 7. 09 ± 3. 78 while group B is 5.62 ± 3. 54 (P = 0. 004). The response rate in group A is 89. 2% which is significantly higher than 76.4% in group B (P=0. 015). Other symptoms for response assessment included loss of appetite, early satiety, fullness after meal, diarrhea. No severe side-effect was found in both groups. Conclusions Combined therapy of compound azintamide and domperidone may lead to bigger improvement in overall efficacy and health related quality of life in patients with functional dyspepsia than use of motility medicine alone. Potential mechanisms that may account for the efficacy of compound azintamide in functional dyspepsia include modulation of visceral sensitivity and/or gastrointestinal motility.%目的 评估复方阿嗪米特肠溶片与促动力剂联合使用对功能性消化不良(FD)患者症状和生活质量的影响.方法 随机、双盲、安慰剂对照临床试验.卫生部北京医院门诊就诊的208例符合罗马

  16. Analysis on 30 Cases of Xuebijing Combined with Domestic Fourteen Peptides Treatment for Acute ;Hemorrhagic Necrotizing Pancreatitis%血必净联合国产十四肽治疗急性出血坏死性胰腺炎30例疗效分析

    Institute of Scientific and Technical Information of China (English)

    倪浩亮

    2015-01-01

    conventional treatment,continuously for 7 days.The observa-tion group received xuebijing injection(50 mL intravenous injection,twice a day) on the basis of the control group′s therapy.The body fluid amylase(EPS assay) of the patients on the first visit and 3 d and 5 d after treatment were recorded;the abdominal bloating and pain, nausea and vomiting, fasting, the incidence of fever,length of hospital stay and complications of the patients were recorded.Results The blood amylase and urine amylase of both groups declined gradually after treatment, observation group declined faster,and the difference between the two groups different time points; groups time points, time points and different groups interactive effects had significont difference (P<0.01).The average abdominal bloating and pain, nausea and vomiting,fasting,fever,hospital stay,and complications of the observation group were significantly lower than the control group[(2.5 ±1.3) d vs (4.4 ±1.3) d,(3.6 ±1.0)d vs (5.1 ±1.1) d,(8.4 ± 1.2) d vs (12.0 ±1.4) d,(4.9 ±1.4) d vs (7.1 ±1.7) d,(16.7 ±2.0) d vs (21.8 ±2.7) d,26.7%vs 36.7%,all P <0.01 ] .Conclusion Xuebijing combined with domestic peptide treatment of AHNP is effective,and worthy of promotion.

  17. BK Virus-Hemorrhagic Cystitis Following Allogeneic Stem Cell Transplantation: Clinical Characteristics and Utility of Leflunomide Treatment

    Directory of Open Access Journals (Sweden)

    Young Hoon Park

    2016-08-01

    Full Text Available Objective: BK virus-hemorrhagic cystitis (BKV-HC is a potential cause of morbidity and mortality in patients having undergone allogeneic stem cell transplantation (Allo-SCT. We analyzed the clinical features of BKV-HC following Allo-SCT and reported the utility of leflunomide therapy for BKV-HC. Materials and methods: From January 2005 to June 2014, among the 69 patients underwent Allo-SCT in our institution, the patients who experienced BKV-HC were investigated retrospectively. Results: Hemorrhagic cystitis (HC was observed in 30 patients (43.5%, and among them, 18 patients (26.1% were identified as BKV-HC. The median age of the patients (12 males and 6 females was 45 years (range, 13-63. Patients received Allo-SCT from acute myeloid leukemia (n=11, aplastic anemia (n=4, myelodysplastic syndrome (n=2, and non-Hodgkin lymphoma (n=1.The donor types were a HLA-matched sibling donor for 6 patients, HLA-matched unrelated donor for 9, and a haploidentical familial donor for 2. The median onset and duration of BKV-HC was on day 21 (range, 7-97 after transplantation and 22 days (range, 6-107. Eleven patients (62.1% had grade I-II HC and seven patients (38.9% had grade III-IV (high-grade HC. Among the seven patients who had high-grade HC, one had complete response (CR, one partial response (PR, and five no response (NR. Among the five non-responders, one died of BKV-HC associated complications. The remaining four patients were treated with leflunomide, with achieving CR (n=2 and PR (n=2. The median duration from the start of leflunomide therapy to response was 13 days (range, 8–17 days. All patients tolerated the leflunomide treatment well, with three patients having mild gastrointestinal symptoms, including anorexia and abdominal bloating. Conclusion: BKV-HC was commonly observed in patients with HC following Allo-SCT. In high-grade BKV-HC patients who fail supportive care, leflunomide may be a feasible option without significant toxicity. Materials

  18. Clinical efficacy of glutamine compound joint mesalamine in treatment of nonspecific small ulcer%复方谷氨酰胺联合美莎拉嗪治疗非特异性小肠溃疡的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    郑荣娟; 郝丽君; 赵莉; 胡爱萍; 吴贵楷

    2015-01-01

    Objective To investigate the clinical efficacy of glutamine compound joint mesalamine in treatment of nonspecific small ulcer.Methods Selected 72 cases of non specific small ulcer patients, they were randomly divided into two groups with 36 patients in each group, the observation group were used Sarah triazine compound joint US glutamine treatment, the control group received glutamine compound treatment, four weeks as a course of treatment, observation intestinal symptoms in patients before and after treatment, diarrhea, abdominal pain and bloating of patients were recorded, improvement of symp-toms and clinical efficacy were evaluated.Results After four weeks of treatment, observation and control groups’ total effi-ciency were 97.2%and 80.5%respectively, the total efficiency of the observation group was significantly higher than that of control group (χ2 =20.71, P <0.05).After two and four weeks of treatment, diarrhea were reduced in both of the two groups (control group:t =3.95, t =3.76, observation group:t =3.23, t =3.11, P <0.05), observation group was better than control group ( t =2.36, t =2.41, P <0.05) .Abdominal pain, bloating and diarrhea were relieved than before treat-ment in both group (control group:t =6.18, t =4.07, t =4.26, observation group:t =6.31, t =4.52, t =4.76, P <0.05), and observation group was better than that of control group ( t =2.97, t =2.65, t =2.58, P <0.05).Compared with before treatment, serum TNF-α, IL-6, IL-8 levels were decreased in both of the two groups ( observation group:t =4.35, t =4.51, t =4.43, control group:t =4.18, t =4.45, t =4.37, P <0.05), observation group were significantly lower than that of the control group, the difference was statistically significant ( t =2.85, t =2.91, t =3.19, P <0.05). Conclusion Sarah triazine compound glutamine joint US in treatment of nonspecific small ulcer effect has obvious effect, its worthy of clinical application.%目的:观察复方谷氨酰胺联合美莎拉嗪治疗非特

  19. Inclusão dos sintomas na discriminação entre tumores anexiais benignos e malignos Inclusion of symptoms in the discrimination between benign and malignant adnexal masses

    Directory of Open Access Journals (Sweden)

    Caio Augusto Hartman

    2012-11-01

    áusea e/ou vômito, irregularidade menstrual, perda de peso, diarreia e sinusorragia foram semelhantes nos dois grupos. CONCLUSÕES: Em mulheres com tumores anexiais com indicação cirúrgica, a avaliação pré-operatória dos sintomas pode auxiliar na predição da malignidade.PURPOSE: To assess the association between clinical symptoms and the diagnosis of malignancy in women with adnexal tumors who underwent surgery. METHODS: Cross-sectional study, in which 105 women with adnexal tumors and indication for laparotomy/laparoscopy were included. All women were treated at a teaching hospital in the state of São Paulo between November 2009 and March 2011. All patients underwent a structured interview about the occurrence of 18 symptoms associated with ovarian cancer. The interview included the severity, frequency, and duration of these symptoms in the 12 months prior to the first medical consultation. The CA125 levels and the ultrasound classification of the tumors were also evaluated. We calculated for each symptom the prevalence ratio with 95% confidence intervals. The golden-standard was the result of the pathological examination of the surgical specimens. RESULTS: Of the 105 women included, 75 (71.4% had benign tumors and 30 (28.6% had malignant ones. In women with malignant tumors, the most frequent symptoms were: abdominal bloating (70%, increased abdominal size (67%, pelvic pain (60%, menstrual irregularity (60%, swelling (53%, abdominal pain (50%, backache (50%, and early repletion (50%. Women with benign tumors showed essentially pelvic pain (61%, menstrual irregularities (61%, and abdominal swelling (47%. Symptoms significantly associated with malignancy were: bloating (PR=2.0; 95%CI 1.01 - 3.94, increased abdominal size (PR=2.16; 95%CI 1.12 - 4.16, backache (RP=1.97; 95%CI 1.09 - 3.55, swelling (PR=2.25; 95%CI 1.25 - 4.07, early repletion (RP=2.06; 95%CI 1.14 - 3.70, abdominal mass (PR=1.83; 95%CI 1.01 - 3.30, eating difficulties (PR=1.98; 95%CI 1.10 - 3

  20. 麻仁软胶囊对便秘的疗效及其安全性考察%Effect and safety of Maren Soft Capsule on constipation

    Institute of Scientific and Technical Information of China (English)

    李东冰; 谢振年; 李友峰; 蔡亭; 王淑媛

    2013-01-01

    Objective To explore the effect of low-dose Maren Soft Capsule (MSC) on constipation and colonic mucosa.Methods Patients (208 cases) with colon slow transit constipation and mixed constipation were divided into treatment and control groups.MSC (two pills,once daily) and Sennae Folium (5 g) were given to the patients in the treatment and control groups,respectively,for 10 months.The recovery rate,total significant efficiency,and total efficiency were determined by defecation frequency and gastrointestinal transmission experiment.The side effects such as bloating and abdominal pain were observed.Results The recovery rate in the treatment group was lower than that in the control group,and the total significant efficiency and total efficiency were similar to those in the control group.There was no colon melanosis in the treatment group after 10 month,while 26.9% of the patients in the control group were observed with colon melanosis.Conclusion The low-dose MSC has the therapeutic effect on constipation with high safety.%目的 观察麻仁软胶囊对便秘的疗效和对结肠黏膜的影响.方法 结肠慢传输型及混合型便秘的门诊患者208例随机分为治疗组及对照组.治疗组患者每日口服麻仁软胶囊1次,每次2粒,连续服用10个月;对照组患者每日口服番泻叶5 g(沸水100 mL浸泡后顿服)1次,连续服用10个月.根据排便次数和胃肠传输实验(GITT)判断治愈率、总显效率(治愈率+显效率)、总有效率(总显效率+有效率).依据腹胀、腹痛等判断不良反应.治疗10个月后肠镜观察结肠黏膜黑变情况.结果 治疗组的治愈率略低于对照组,总显效率、总有效率与对照组无显著差异,治疗组患者服药后10个月后镜检未发现结肠黑变,而对照组26.9%患者结肠黑变.结论 低剂量麻仁软胶囊治疗便秘有效,并具有较高安全性.

  1. Clinical Research on Tongmi Wan Treatment of Intestinal Excess Heat Type Constipation%通秘丸治疗肠道实热型便秘临床研究

    Institute of Scientific and Technical Information of China (English)

    刘佃温; 刘翔; 杨会举

    2014-01-01

    Objective:To observe the efficacy and safety of Tongmi Wan treatment of intestinal excess heat type constipation. Methods:54 cases of patients were randomly divided into the treatment group and the control group,27 cases in each group. The control group was given muxiang binglang pill,and the treatment group was treated with Tongmi Wan. Comparison of symptoms improvement such as defe-cation exertion,quality,abdominal bloating,loss of appetite,dry mouth and adverse reaction of the two groups. Results:The therapeutic effect of the treatment group was better than the control group(P < 0. 05). After treatment,syndrome integrals of the two groups in four aspects of defecation exertion,quality,abdominal distention,loss of appetite,dry mouth were decreased from 70% to 94% ,and sugges-ting that the effect was significant,and dry mouth syndrome integral reduction in 30% - 69% ,suggesting effective. Improvement of symptoms such as defecation exertion,quality,abdominal distention,loss of appetite of the treatment group were significantly better the control group(P < 0. 05). Follow up of the six months,the two groups were no obvious adverse reaction. Conclusion:Tongmi Wan treat-ment of intestinal excess heat type constipation is safe and effective.%目的:观察通秘丸治疗肠道实热型便秘的有效性及安全性。方法:54例肠道实热型便秘患者按随机数字表法分为治疗组和对照组,每组各27例。对照组给予木香槟榔丸,治疗组采用通秘丸治疗。比较两组排便费力、便质、腹部胀满、食欲不振、口干等症状的改善及不良反应。结果:两组疗效经统计学处理,治疗组优于对照组(P <0.05)。两组治疗前后其排便费力、便质、腹部胀满、食欲不振四方面,证候积分减少70%~94%,提示具有显著疗效,口干证候积分减少30%~69%,提示有效。在排便费力、便质、腹部胀满、食欲不振症状改善方面,治疗

  2. Estudo prospectivo e randomizado comparando solução de fosfato de sódio oral e manitol para o preparo de cólon para colonoscopia Mechanical bowel preparation with oral sodium phosphate solution for colonoscopy. A new small volume solution compared to the traditional mannitol

    Directory of Open Access Journals (Sweden)

    Lúcia Câmara Castro Oliveira

    1999-12-01

    -sum test and Fisher 's exact test. Between April 96 and 98, 220 patients were prospectively randomized to receive either mannitol or sodium phosphate solutions, and completed all phases 01 the trial. Patient's tolerance for both solutions was similar except for abdominal pain and bloating, that were more common with oral mannitol. Conversely, patients tolerance to sodium phosphate was poor due to oral taste (p=0.0043. The quality of preparation was similar for both solutions. However the exam was interrupted in 8 and 5 patients who took mannitol and sodium phosphate, respectively (p =0.56 There was no morbidity or mortality in this series. Although quality of both preparations was similar; oral sodium phosphate was better tolerated overall. Both oral solutions proved to be effective and safe. Sodium phosphate was related to less dehydration and overall cost. In addition, patient tolerance of the smaller volume of sodium phosphate may be a clear advantage over the traditional mannitol.

  3. ASTRO-ENTOMOLOGY? ANT-LIKE SPACE STRUCTURE PREVIEWS DEATH OF OUR SUN

    Science.gov (United States)

    2002-01-01

    From ground-based telescopes, the so-called 'ant nebula' (Menzel 3, or Mz 3) resembles the head and thorax of a garden-variety ant. This dramatic NASA/ESA Hubble Space Telescope image, showing 10 times more detail, reveals the 'ant's' body as a pair of fiery lobes protruding from a dying, Sun-like star. The Hubble images directly challenge old ideas about the last stages in the lives of stars. By observing Sun-like stars as they approach their deaths, the Hubble Heritage image of Mz 3 -- along with pictures of other planetary nebulae -- shows that our Sun's fate probably will be more interesting, complex, and striking than astronomers imagined just a few years ago. Though approaching the violence of an explosion, the ejection of gas from the dying star at the center of Mz 3 has intriguing symmetrical patterns unlike the chaotic patterns expected from an ordinary explosion. Scientists using Hubble would like to understand how a spherical star can produce such prominent, non-spherical symmetries in the gas that it ejects. One possibility is that the central star of Mz 3 has a closely orbiting companion that exerts strong gravitational tidal forces, which shape the outflowing gas. For this to work, the orbiting companion star would have to be close to the dying star, about the distance of the Earth from the Sun. At that distance the orbiting companion star wouldn't be far outside the hugely bloated hulk of the dying star. It's even possible that the dying star has consumed its companion, which now orbits inside of it, much like the duck in the wolf's belly in the story 'Peter and the Wolf.' (See http://oposite.stsci.edu/pubinfo/qt/ssudec.mov for an animation that shows how this might work.) A second possibility is that, as the dying star spins, its strong magnetic fields are wound up into complex shapes like spaghetti in an eggbeater. Charged winds moving at speeds up to 1000 kilometers per second from the star, much like those in our sun's solar wind but millions of

  4. 胰腺转移癌10例诊断及治疗%Diagnosis and treatment of metastatic pancreatic tumor with a case series of 10 patients

    Institute of Scientific and Technical Information of China (English)

    孟凡斌; 郭克建; 赵梅芬

    2008-01-01

    Objective To describe the diagnosis and treatment of metastatic pancreatic cancer. Methods The clinical data of 10 cases of metastatic pancreatic tumor in the first affiliated hospital of China Medical University from July 1997 to July 2007 were analyzed retrospectively. Results The etiologies of primary tumors were lung cancer(n=3), colonic carcinoma(n=2), stomach cancer(n=2), renal cell carcinoma(n=2), nasopharyngeal carcinoma(n=1). The median interval between the diagnosis of primary tumor and pancreatic metastases was 40 months (range:0~192 months). All the metastases were located in the pancreatic heed and neck, and solitary metastasis was detected in one ease, while other 9 cases were multiple metastases. The mean maximum tumor size was 3.03 cm. The main clinical manifestations were abdominal pain, bloating, anorexia and jaundice. 2 cases underwent pancreaticoduodeneetomy, 1 case underwent arterial pancreatic perfusion chemotherapy, 1 case underwent percutaneous biliary stenting and 2 cases received systematic chemotherapy, 1 case received radiotherapy, 3 patients did not accept any therapy. 7 patients were followed-up, the median survival was 10.6 months (range:2~44 months). Conclusions Metastatic pancreatic cancer was rare and the clinical manifestation was non-specific, lndividuaized treatment should be selected on a case-by-case basis. Aggressive surgical resection should be offered to some selected patients.%目的 探讨胰腺转移癌的诊断及治疗方法.方法 对1997年7月至2007年7月中国医科大学附属第一医院收治的10例胰腺转移癌进行回顾性分析.结果 原发肿瘤为肺癌3例、结肠癌2例、胃癌2例、肾癌2例、鼻咽癌1例.胰腺转移距发现原发肿瘤时间间隔平均40个月(0-192个月).10例转移灶均位于胰腺头颈部,单发9例,多发1例,肿瘤最大径平均3.03cm.主要临床表现为腹痛、腹胀、厌食、黄疸等.行胰十二指肠切除术2例.胰动脉灌注化疗1例,经皮

  5. 指固有动脉皮支血管链逆行侧方皮瓣修复手指软组织缺损%Flap Pedicled with Lateral Vascular Chain of Cutaneous Branch of Digital Artery to Repair the Soft Tissue Defect of the Distal Finger

    Institute of Scientific and Technical Information of China (English)

    李超; 王浩; 潘朝晖

    2014-01-01

    目的:探讨指固有动脉皮支血管链逆行侧方皮瓣修复手指远端软组织缺损的效果。方法以指固有动脉背侧皮支上行支、下行支形成的链式吻合供血,在手指近节侧方切取皮瓣。皮瓣的轴线是手指侧方中线,皮瓣旋转点为中节指体中远端,皮瓣的蒂部宽度为0.5~1.0cm。皮瓣携带指背神经与创面指神经断端进行缝合修复,重建手指感觉。逆行移位皮瓣修复指端创面32例。结果32例皮瓣全部成活。术后随访6个月~1年,皮瓣外形与正常相近,弹性、色泽良好。缺损饱满而不臃肿,质地柔软,有排汗功能,两点辨别觉达5~9 mm。结论采用指固有动脉皮支血管链逆行侧方皮瓣一期修复指端缺损,疗程短,效果好,操作简单,血供可靠,不牺牲指固有动脉、神经,供区损伤小,术后并发症少,并且能重建皮瓣感觉,是一种理想的手术修复方法。%Objective To explore the effect of flap pedicled with lateral vascular chain of cutaneous branch of digital artery to re -pair the soft tissue defect of the distal finger .Methods The flap based on the dorsal cutaneous branch of digital artery ,the ascending branch and the descending branch formation of supply vascular chain in the finger's lateral.The axis of the flap was finger lateral midline , the rotation point of flap was the middle finger of the distal , and the pedicle width of flap was 0.5~1.0cm.Flap repaird dorsal nerve and stump nerve , reconstructed of the finger's feeling.Retrograde transposition of flap in 32 cases to repair finger end .Results All flaps survived in 32 cases. After followed up for 6 months~1 years,flap had the normal close,elastic,good colour.Defect was full and not bloated , and soft texture,had the function that discharge sweat ,two-point discrimination Jueda 5~9mm.Conclusion Flap pedicled with lateral vascular chain of cutane-ous branch of digital artery to repair the

  6. Magnetic resonance enterography or video capsule endoscopy – what do Crohn’s disease patients prefer?

    Directory of Open Access Journals (Sweden)

    Lahat A

    2016-06-01

    , bloating, and abdominal pain were all significantly more prominent in MRE as compared to CE (P<0.0001, P<0.0001, P<0.0001, P=0.009, P=0.0002, P<0.0001, respectively. MRE was perceived as a more difficult procedure (P<0.0001. Furthermore, MRE was associated with a specific adverse event – claustrophobia. Seventy-eight percent of patients (44 patients preferred to repeat CE as compared to 22% (P<0.0001 who preferred MRE.Conclusion: CE was better tolerated by CD patients compared to MRE and was preferred by 78% of patients. The superior tolerability of CE should be considered along with the diagnostic features, and more data sought when choosing between these two modalities for CD patients for long-term follow-up. Keywords: inflammatory bowel disease, Crohn’s imaging, MRE, capsule endoscopy, patients’ preference 

  7. Gambaran Klinis dan Endoskopi Saluran Cerna Bagian Atas Pasien Dispepsia di Bagian RSUP Dr. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Citra Yuriana Putri

    2016-08-01

    Full Text Available AbstrakDispepsia ialah suatu sindrom yang terdiri dari nyeri atau rasa tidak nyaman di ulu hati, kembung, mual, muntah, sendawa, rasa cepat kenyang, perut rasa penuh/begah. Salah satu alat diagnostik untuk dispepsia adalah endoskopi. Alat ini dapat menentukan jenis lesi dan lokasi lesi pada saluran cerna atas pasien dispepsia. Tujuan penelitian ini adalah mementukan frekuensi keluhan, derajat keluhan, insiden pasien dispepsia yang mengalami tanda bahaya berdasarkan jenis kelamin, faktor risiko dispepsia, diagnosis endoskopi  dan lokasi lesi saluran cerna atas pasien dispepsia. Desain penelitian ini adalah deskriptif observasional. Subjek penelitian  terdiri dari 54 orang pasien dispepsia yang dilakukan pemeriksaan esofagogastroduodenoskopi (EGD di RSUP Dr. M. Djamil dari Mei hingga Juni 2014. Data dikumpulkan dengan cara pengisian kuisioner melalui wawancara, pencatatan hasil pemeriksaan endoskopi. Hasil penelitian didapatkan bahwa keluhan terbanyak dari pasien dispepsia adalah nyeri ulu hati (98,15%, derajat keluhan terbanyak adalah derajat sedang (38,89%, insiden tanda bahaya lebih banyak pada pria, faktor risiko terbanyak adalah konsumsi makanan berlemak (92,59%, diagnosis endoskopi dispepsia terbanyak adalah gastritis (61,11%, lokasi lesi saluran cerna atas terbanyak adalah gaster (85,19%. Kata kunci: dispepsia, gambaran klinis, endoskopi AbstractDyspepsia is a syndrome that consist of pain or discomfort in upper abdominal, bloating, nausea, vomiting, bletching, early satiation  and post-prandial fullness. One of the diagnostic tool for dyspepsia was endoscopy. It can be determined the type and the location of upper gastrointestinal’s lesions in patient with dyspepsia. The objective of this study was to determined the frequency of dyspepsia’s complaints, the degree of dyspepsia’s complaints, the incident of alarm sign based on gender, the frequency of  risk factors of dyspepsia, endoscopic diagnosis and the location of upper

  8. Safety, efficacy and patient satisfaction with continuous daily administration of levonorgestrel/ethinylestradiol oral contraceptives

    Directory of Open Access Journals (Sweden)

    Giuseppe Benagiano

    2009-04-01

    empirically utilized various continuous administration regimens. The first extended-cycle oral contraceptive regimen introduced in clinical practice is an 84-day regimen that results in bleeding only 4 times a year. A commercial product specifically packed for continuous use is now available in Europe and contains 30 µg EE and 150 µg LNG. In a variation of this regimen, after administration of the same combination for 84 days, women are given 7 pills containing 10 µg EE. A 6-monthly regimen has also been tested in a small study using EE 20 µg plus LNG 100 µg taken with and without a hormone-free interval. Women in the continuous group reported significantly fewer bleeding days requiring protection and were more likely to have amenorrhea; in addition they also reported significantly fewer days of bloating and menstrual pain. A yearly regimen is now being developed. Each pill of this novel formulation contains EE 20 µg and LNG 90 µg to be taken continuously for 364 days (13 cycles per year. A phase III trial has now evaluated safety, efficacy and menses inhibition. At the end of the 1-year trial amenorrhea was present in 58.7% of the women and a complete absence of bleeding in 79.0%. Overall, the number of bleeding and spotting days per pill pack declined with time and adverse events and discontinuations were comparable to those reported for cyclic oral contraceptive regimens.Keywords: levonorgestrel, oral contraceptive, continuous administration, menstruation, amenorrhea

  9. Relationship of Gastric pH Value and Feeding Intolerance in Very Low Birth Weight Infants (VLB-WI)%极低出生体重儿胃液 pH 值与喂养不耐受的相关性研究

    Institute of Scientific and Technical Information of China (English)

    郝群英

    2016-01-01

    Objective]To explore the relationship of gastric pH value and feeding intolerance in very low birth weight infant (VLBWI).[Method]80 cases of very low birth weight children in our hospital from January 2010 to December 2014 also in the neonatal intensive care unit were chosen for our study.Using the feeding intolerance di-agnostic criteria,the children were selected and divided into two groups.Group 1 had no feeding intolerance (36 cases)and Group 2 had feeding in tolerance (44 cases).The two groups of children were observed in respect to gastric pH value,feeding conditions (feeding time,the amount of intake and gastric residue),and feeding toler-ance (bloating times,frequency of vomiting,abnormal stool frequency).[Results]Group 1 had a feeding intoler-ance rate of 100%,significantly higher than the 8.33% rate in Group 2 (P <0.05),while the average gastric pH value was also higher in Group 1 than Group 2 (P <0.05).The occurrence of VLBWI feeding intolerance and gas-tric pH value were positively correlated r =0.77,P =0.00.[Conclusion]Gastric pH value in very low weight new-borns with feeding intolerance showed significant correlation with the gastric pH levels in the infants.It is worthy of effective monitoring to help clinicians and nurses to understand neonatal gastrointestinal function and promote neonatal rehabilitation reference.%【目的】探讨极低出生体重儿(VLBWI)胃液 pH 值与喂养不耐受的关系。【方法】选取2010年1月至2014年12月本院新生儿重症监护室(NICU)收治的 VLBWI 80例。参照喂养不耐受诊断标准,将入选患儿分为喂养耐受组36例,喂养不耐受组44例。比较两组患儿的胃液 pH 值、喂养耐受情况(胃残留量、腹胀、呕吐、大便异常)。【结果】喂养不耐受组喂养不耐受发生率为100%,高于喂养耐受组的8.33%(P <0.05),同时其平均胃液 pH 值高于喂养不耐受组(P <0.05);VLBWI 胃液 pH 值与胃残留量呈正相关,r =0.77,P =0.00

  10. Ileocecal valve dysfunction in small intestinal bacterial overgrowth: A pilot study

    Institute of Scientific and Technical Information of China (English)

    Larry S Miller; Anil K Vegesna; Aiswerya Madanam Sampath; Shital Prabhu; Sesha Krishna Kotapati; Kian Makipour

    2012-01-01

    air insufflation 21.23 ± 3.52 mmHg vs 16.10 ± 3.39 mmHg.The average percentage difference of the area under the pressure curve of the ICV from the cecum during air insufflation was not significantly different 101.08% ± 7.96% vs 100% ±0%.The total symptom score for subjects with normal lactulose breath tests and subjects with positive lactulose breath tests was not statistically different (13.30 ±4.09 vs 24.14 ± 6.58).The ICV peak pressures during air insufflations were significantly higher in subjects with normal lactulose breath tests than in subjects with positive lactulose breath tests (P =0.005).The average percent difference of the area under the pressure curve in the ICV from cecum was significantly higher in subjects with normal lactulose breath tests than in subjects with positive lactulose breath tests (P =0.0012).Individuals with positive lactulose breath tests demonstrated symptom scores which were significantly higher for the following symptoms:not able to finish normal sized meal,feeling excessively full after meals,loss of appetite and bloating.CONCLUSION:Compared to normal,subjects with a positive lactulose breath test have a defective ICV cecal distension reflex.These subjects also more commonly have higher symptom scores.

  11. Application of Nasal obstruction catheter insertion in the treatment of early postoperative inflammatory ileus%经鼻插入型肠梗阻导管在治疗术后早期炎性肠梗阻中的应用

    Institute of Scientific and Technical Information of China (English)

    苏冀

    2013-01-01

    Objective To explore the application of ileus tube in early postoperative inflammatory small bowel obstruction. Methods From January 2006 to March 2013, According to the Sequence of hospitalization, 50 patients with early postoperative inflammatory small bowel obstruction were divided into two groups respectively:the group with ilues tube (25 cases) and the Group with nasogastrictube (25 cases). Abdominal distension symp-tom, borborygmus,abdominal circumference,gastrointestinal Decompression amounts, plain abdominal radiogra-phy,time of bowel movements and fart,abdominal plain film and the disappearing time of liquid and gas were ob-served and compared. Results Compared with the nasogastric tube group, nasal obstruction catheter insertion in patients abdominal pain, bloating and other abdominal symptoms relief time, recovery time of bowel sounds, ex-haust and defecation was significantly shorter recovery time, decompression increased significantly. Conclusion The ilues tube can more effectively drain digestive juice,relieve intestional dilatation and promotein testional peristalsis.The ilues tube has a notably treatment effect to the patients with early postoperative inflammatory Small bowel obstruction.%目的:探讨经鼻插入型肠梗阻导管治疗术后早期炎性肠梗阻的临床疗效。方法:对我院2006年1月~2013年3月期间50例腹部术后早期炎性肠梗阻患者分为经鼻插入型肠梗阻导管组和普通鼻胃管组进行治疗,观察患者腹痛、腹胀等腹部症状缓解情况、肠鸣音变化、腹围、胃肠减压量、排气排便恢复时间、X线立卧位腹平片、气液平面消失时间等指标。对结果进行分析比较。结果:与鼻胃管组相比较,经鼻插入型肠梗阻导管组患者腹痛、腹胀等腹部症状缓解时间、肠鸣音恢复时间、排气与排便恢复时间明显缩短,胃肠减压量显著增加。结论:经鼻插入型肠梗阻导管能更有效胃肠减压,减轻

  12. Bezoar de madeira em trato gastrointestinal: relato de caso e revisão da literatura Wood bezoar in the gastrointestinal tract: case report and literature review

    Directory of Open Access Journals (Sweden)

    Jair Gimenez Marra

    2007-12-01

    large wood bezoar. CASE REPORT: R.F.L, a 20-year-old female, presenting neuropsychiatric disorder and history of ingesting matchsticks and colored pencils for over four years. She was admitted to our service feeling bloated, with abdominal pain and vomiting. Physical examination showed thin patient, pale skin, and slightly distended and painful abdomen. X-ray study showed numerous foreign bodies impacted in gastric region reaching the proximal section of the small intestine. She received tube feeding containing mineral oil and saline solution that resulted in elimination of a large amount of phytobezoars within the excrements. CONCLUSION: The association of bezoars with psychiatric disorders is relevant and may be recurrent. If possible these patients should be treated conservatively. Endoscopy has been shown to be the technique of choice, although its limitation depends on nature and quantity of bezoars. Surgical removal consists of longitudinal anterior gastrostomy as the preferred surgical procedure.

  13. Globálny vývoj ekonomiky a trendy na finančných trhoch

    Directory of Open Access Journals (Sweden)

    Miloš Bikár

    2013-10-01

    non-financial institutions, and the consolidation of fiscal accounts has barely started. International financial imbalances are re-emerging. Highly accommodative monetary policies are fast becoming a threat to price stability. Financial reforms have yet to be completed and fully implemented. And the data frameworks that should serve as an early warning system for financial stress remain underdeveloped. Conclusions: Interrelated imbalances made pre-crisis growth in several advanced countries unsustainable. Rapidly increasing debt and asset prices resulted in bloated housing and financial sectors. The boom also masked serious longterm fiscal vulnerabilities that, if left unchecked, could trigger the next crisis.The lessons of the crisis apply to emerging market economies, too. And those where debt is fuelling huge gains in property prices and consumption are running the risk of building up the imbalances that now plague the advanced economies.

  14. 手部多指或多处复杂性软组织缺损皮瓣Ⅰ期修复%Stage Ⅰ flap prosthetics of complex soft tissues defect of multi-fingers or multiple damaged sites in hands

    Institute of Scientific and Technical Information of China (English)

    谭耀灵; 许球祥; 余紫丹

    2015-01-01

    liposuctions at stage Ⅱ because of postsurgical bloated flap. Conclusion Proper stage Ⅰ flap prosthetics can have a better curative effect based on complex soft tissues defect of multi-fingers or multiple damaged sites in hands.

  15. Lubiprostone: RU 0211, SPI 0211.

    Science.gov (United States)

    2005-01-01

    Lubiprostone [RU 0211, SPI 0211] is a bicyclic fatty acid that acts as a chloride channel opener, increasing intestinal water secretion. Lubiprostone, an orally-administered formulation, is one of a series of functional fatty acid compounds discovered by Dr Ryuji Ueno, and is currently undergoing development for the treatment of constipation, constipation-predominant irritable bowel syndrome (IBS-C) and postoperative ileus with Sucampo Pharmaceutical's. Lubiprostone activates a specific chloride channel (CLC2) on cells lining the gut, thereby naturally increasing intestinal fluid secretion. The increased fluid level softens the stool, promotes spontaneous bowel movements, and reduces abdominal discomfort/pain and bloating. The chloride channel is a protein that controls cell membrane transport of chloride ion. Lubiprostone acts on the ClC-2 chloride channel, which is located in the apical intestinal membrane. In November 2004, Takeda Pharmaceuticals entered into a collaboration and licensing agreement for Lubiprostone with Sucampo Pharmaceuticals for the treatment of chronic constipation and constipation-predominant Irritable Bowel Syndrome (c-IBS). Under the terms of the agreement, Takeda received the right to market the product in the US and Canada, while Sucampo reserved the co-promotion rights for these countries. Takeda's wholly-owned US subsidiary, Takeda Pharmaceuticals North America Inc., will sell lubiprostone once the product is approved by the US FDA. Takeda will also receive an option for marketing rights in other territories, including Japan and Europe. Takeda and Sucampo agreed on the exclusive manufacturing and supply of Lubiprostone by R-Tech Ueno, Ltd, a member of the Sucampo Group. Sucampo has the potential to receive up to dollar US 210 million in initial and milestone payments, some of which are contingent upon the successful achievement of several milestones. Takeda will fund a major part of development costs not only for chronic constipation

  16. KANDUNGAN VITAMIN B6, B9, B12 DAN E BEBERAPA JENIS DAGING, TELUR, IKAN DAN UDANG LAUT DI BOGOR DAN SEKITARNYA (VITAMIN B6, B9, B12 AND E CONTENT OF SEVERAL TYPES OF MEATS, EGGS, FISHES AND MARINE SHRIMPS IN BOGOR AND SURROUNDING AREAS

    Directory of Open Access Journals (Sweden)

    Heru Yuniati

    2012-06-01

    Full Text Available ABSTRACT Food Composition Table (DKBM in Indonesia has not mentioned all types of nutrients available in the food, particularly vitamin B6, B9 (folic acid, B12, and vitamin E. Therefore this study aimed to analyze the content of vitamin B6, B9 (folic acid, B12, and vitamin E in several types of meat, eggs, fish and marine shrimps consumed in Bogor and surrounding areas. Vitamin B6, B9, B12, and vitamin E from three kinds of meat (chicken, beef, lamb, two types of eggs (chicken, duck, and four species of fish (snapper, bloating, carp and tuna and crayfish are analyzed using High-Performance Liquid Chromatography (HPLC. The samples used are raw and taken from three locations in Bogor and surrounding areas. Fishes, meats and eggs contain high levels of folic acid, however the amount of folic acid content in meat varies depending on which part of meat the samples are taken, types of organ, and the fat content of the meat. The folic acid content in chicken wings is different with those in thigh. In fatty mutton the folic acid is higher than in those lean meat, and in yolk is higher than those in egg white. Vitamin E content of snapper is the highest amongs other types of fishes (6.54 µg/100 g.Chicken eggs contain a higher amount of vitamin E than duck eggs, while the yolk contains ahigher amount of vitamin E than those egg white. Keywords: animal foods, vitamin B6, vitamin B9 (folic Acid, vitamin B12, vitamin E   ABSTRAK Daftar Komposisi Bahan Makanan (DKBM yang ada di Indonesia belum memuat semua jenis zat gizi dalam makanan, khususnya vitamin B6, B9 (asam folat, B12 dan vitamin E. Menganalisis kandungan vitamin B6, B9 (asam folat, B12, dan vitamin E dalam beberapa jenis daging, telur, ikan dan udang laut yang dikonsumsi masyarakat di Bogor dan sekitarnya. Kandungan vitamin B6, B9, B12 dan vitamin E dari tiga jenis daging (ayam, sapi, kambing, dua jenis telur (ayam, itik, serta empat jenis ikan (kakap, kembung, mas, tongkol dan udang laut

  17. Laparoscopic anti-reflux surgery for gastroesophageal reflux disease with hiatal hernia:A clinical analysis of 650 patients%腹腔镜手术治疗胃食管反流病合并食管裂孔疝650例临床分析

    Institute of Scientific and Technical Information of China (English)

    克力木; 阿力木江·麦斯依提; 张成; 阿扎提江; 皮尔地瓦斯; 王志

    2014-01-01

    Objective To evaluate the efficacy and safety of laparoscopic hiatal hernioraphy plus fundoplication for gastroesophageal reflux disease (GERD). Methods The clinical data of 650 patients underwent laparoscopic hiatal hernioraphy plus fundoplication from September 2005 to August 2013 in People’s Hospital of Xinjiang Uyghur Autonomous Region were analyzed retrospectively. Results Laparoscopic hiatal herniorrhaphy plus fundoplication were successfully performed in all 650 patients without conversion. Combined operation was performed in 135 patients (20.8%). The average duration of operation was 64.3 min (45-90min) and the average amount of bleeding was 18 mL (5-50mL). No intraoperative or postoperative blood transfusion. Liquid diet was used in 24-48 h after operation. Postoperative hospital stay was 2-8 d. All the patients were followed up for 6 months to 8 years. Postoperative dysphagia occurred in 21 patients. Recurrent hiatal hernia (gastric wrap herniated into the chest) occurred in 4 patients. Recurrence of symptoms occurred in 14 patients. Gas bloating syndrome occurred in 6 patients. Conclusion Laparoscopic hiatal hernioraphy plus fundoplication is safe and effective with less invasive,faster recovery,fewer complication, which can combine surgical treatment of other diseases and is the ideal choice for GERD with hiatal hernia.%目的:探讨腹腔镜下抗反流手术治疗胃食管反流病(GERD)合并食管裂孔疝的安全性和疗效。方法回顾性分析2005年9月至2013年8月新疆维吾尔自治区人民医院收治的650例GERD合并食管裂孔疝病人的临床资料,均行腹腔镜食管裂孔疝修补术+胃底折叠术。结果650例均成功完成腹腔镜食管裂孔疝修补+胃底折叠术,无一例中转开腹或开胸。其中联合手术135例,占20.8%。手术时间平均64.3(45~90)min;术中出血量平均18(5~50)mL,无术中术后输血者。术后24~48 h全流饮食。术后住院2~8 d。650

  18. Sintered bentonite ceramics for the immobilization of cesium- and strontium-bearing radioactive waste

    Science.gov (United States)

    Ortega, Luis Humberto

    were also tested. The final solid product was a hard dense ceramic with a density that varied from 2.12 g/cm3 for a 19% waste loading with a 1200°C sintering temperature to 3.03 g/cm 3 with a 29% waste loading and sintered at 1100°C. Differential Scanning Calorimetry and Thermal Gravimetric Analysis (DSC-TGA) of the loaded bentonite displayed mass loss steps which were consistent with water losses in pure bentonite. Water losses were complete after dehydroxylation at ˜650°C. No mass losses were evident beyond the dehydroxylation. The ceramic melts at temperatures greater than 1300°C. Light flash analysis found heat capacities of the ceramic to be comparable to those of strontium and barium feldspars as well as pollucite. Thermal conductivity improved with higher sintering temperatures, attributed to lower porosity. Porosity was minimized in 1200°C sinterings. Ceramics with waste loadings less than 25 wt% displayed slump, the lowest waste loading, 15 wt% bloated at a 1200°C sintering. Waste loading above 25 wt% produced smooth uniform ceramics when sintered >1100°C. Sintered bentonite may provide a simple alternative to vitrification and other engineered radioactive waste-forms.

  19. ALMA喉罩在乳腺外科全身麻醉术中临床效果的比较%Comparison of clinical effect of ALMA laryngeal mask on general anaesthesia breast operation

    Institute of Scientific and Technical Information of China (English)

    唐帅; 尚游

    2015-01-01

    目的:比较将ALMA喉罩的两种置入方法用于乳腺外科手术全身麻醉中的效果。方法选取全身麻醉下行乳腺外科手术患者80例。随机数字表法分为标准正中置入喉罩组( A组)和入口后部分充气侧方置入喉罩组(B组)。记录两组的一次置入成功率、置入时间、置入总成功率、气道压、口咽腔漏气压、术中需调整喉罩情况、术后咽痛和拔出喉罩沾有血迹情况,并观察有无其他并发症的发生。结果 A组和B组喉罩一次置入成功率、喉罩成功置入时间、咽痛及拔出喉罩沾有血迹的发生率,有统计学意义( P 0.05)。结论入口后部分充气侧方置入ALMA双管喉罩法,较传统标准正中置入法更为实用方便,一次置入成功率高,且置入时间更短,减少了术后咽痛和黏膜损伤并发症的发生,值得临床推广。%Objective To compare the effect of two implantation methods of ALMA laryngeal mask during the general anesthesia for breast operation. Methods Under general anesthesia, 80 cases of patients undergone the breast operation were randomly divided into standard median LMA group ( Group A) and partial aeration lateral LMA implantation after entrance group (Group B). The success rate of first implantation, implantation time, implantation total success rate, airway pressure, pharyngo-oral cavity leak pressure, intraoperative adjustment of laryngeal mask, postoperative sore throat and bloodstain when laryngeal mask pulled out were recorded, meanwhile, the incidence of other complications were observed. Results Comparison between Group A and Group B, success rate of the first la-ryngeal mask implantation, laryngeal mask implantation time, sore throat occurrence rate and the incidence of blood-stain when laryngeal mask pulled out showed statistical significance ( P 0. 05). Oxygen desaturation, bronchial spasm, dysphagia, aspiration, bloating and hoarseness complications did not appear in two

  20. Clinical Observation on Fire Needle Therapy for Gastroesophageal Reflux Disease%火针治疗胃食管反流病临床观察

    Institute of Scientific and Technical Information of China (English)

    李永红; 张万龙; 汪芗; 杨文婷; 钟亚彬; 王丹; 张俞

    2015-01-01

    Objective To observe the fire needle therapy for GERD symptom scores and endoscopic results impact. Methods Fifty six patients were randomly divided into two groups. Patients in the treatment group received acupuncture combined with fire needles. Patients in the control group were given omeprazole treatment for 8 weeks. The therapeutic effects and TCM syndrome scores were observed.(1)Main symptoms:burning sensation after observing sternum heart,chest pain,discomfort Chung.(2)Sub - mouth disease on a sour or bitter taste,stomach contents:chest fullness or pain,acid regurgitation,belching,epigastric noisy,emo-tional irritability or depression,foreign body sensation in the throat,stomach pain or bloating,early satiety,ab-dominal fullness or pain,abnormal stools and other symptoms. Results After treatment,symptom scores im-proved significantly compared with those before treatment(P <0. 05). The 28 cases in treatment group achieved the efficiency rate of 92. 6 % ,and the control group had the efficiency rate of 80. 6% . There was statistically significant difference between the two groups(P <0. 05). Conclusion Fire acupuncture treating gastroesopha-geal reflux disease has a good effect,and it is the economic and secure which should be widely applied.%目的:观察火针疗法对胃食管反流病患者的临床疗效及症状评分的影响。方法将56例随机分为两组,治疗组采用火针结合针刺进行治疗,对照组服用奥美拉唑治疗,疗程9周。观察两组患者治疗后临床疗效及中医症状评分。主症:反酸,嘈杂,胸骨后灼痛,两肋胀满;次症:心烦,易怒,口干口苦,大便秘结等症状变化,采用症状程度评分对治疗前后疗效进行对比。结果两组治疗后,症状评分均较治疗前明显改善(P <0.05)。治疗组28例,有效率92.6%,对照组28例,有效率80.6%%,两组有效率比较,差异有统计学意义(P <0.05),治疗组疗效优于对照组。结

  1. 原发性骨髓纤维化继发门脉高压症六例分析并文献复习%A clinical analysis of six cases of portal hypertension secondary to primary myelofibrosis and review of literatures

    Institute of Scientific and Technical Information of China (English)

    宋志强; 周丽雅

    2010-01-01

    目的 探讨原发性骨髓纤维化(PMF)继发门脉高压症患者的临床特点.方法 对北京大学第三医院确诊的6例PMF继发门脉高压症患者进行临床分析,并进行文献复习.结果 6例患者中,男、女各3例,年龄(52.8±11.7)岁,临床起病至确诊的中位时间为24个月.门脉高压症相关症状主要包括腹胀、腹部包块、呕血和黑便,体征主要包括脾大(均为中重度肿大)、肝大(以轻中度肿大多见)、移动性浊音阳性和腹壁静脉曲张,而黄疸、肝掌和蜘蛛痣少见.大多数患者的肝功能指标正常.门、脾静脉宽度为(16.0±3.2)、(11.0±3.4)mm,2例合并门静脉或脾静脉血栓.1例患者进行了肝穿刺,显示有髓外造血.5例患者接受了门脉高压症相关药物治疗,脾切除术和食管曲张静脉套扎治疗各1例.结论 PMF继发门脉高压症临床罕见,极易误诊.脾大显著