WorldWideScience

Sample records for blisters

  1. Fracture Blisters

    Directory of Open Access Journals (Sweden)

    Uebbing, Claire M

    2011-02-01

    Full Text Available Fracture blisters are a relatively uncommon complication of fractures in locations of the body, such as the ankle, wrist elbow and foot, where skin adheres tightly to bone with little subcutaneous fat cushioning. The blister that results resembles that of a second degree burn.These blisters significantly alter treatment, making it difficult to splint or cast and often overlying ideal surgical incision sites. Review of the literature reveals no consensus on management; however, most authors agree on early treatment prior to blister formation or delay until blister resolution before attempting surgical correction or stabilization. [West J Emerg Med. 2011;12(1;131-133.

  2. Decontamination Data - Blister Agents

    Data.gov (United States)

    U.S. Environmental Protection Agency — Decontamination efficacy data for blister agents on various building materials using various decontamination solutions. This dataset is associated with the following...

  3. Radiation blistering: recent developments

    International Nuclear Information System (INIS)

    Kaminsky, M.; Das, S.K.

    1978-01-01

    Different metals have been proposed for radiation blistering of metals. For example, for the formation of blisters on helium bombarded metal surfaces such models are based on the coalescence of gas bubbles and the build-up of excess gas pressure in the implant region, causing large enough stresses for the occurrence of plastic deformation of the surface regions; or the percolation of helium in the lattice; or the build-up of large, lateral stresses in the implant layer causing buckling. These models are critically reviewed in the light of recent experimental results. A discussion of blistering effects at high doses is included

  4. Blistering and hydride embrittlement

    International Nuclear Information System (INIS)

    Louthan, M.R. Jr.

    1975-01-01

    The effects of hydrogen on the mechanical properties of metals have been categorized into several groups. Two of the groups, hydrogen blistering and hydride embrittlement, are reasonably well understood, and problems relating to their occurrence may be avoided if that understanding is used as a basis for selecting alloys for hydrogen service. Blistering and hydride embrittlement are described along with several techniques of materials selection and used to minimize their adverse effects. (U.S.)

  5. Blistering and bubble formation

    International Nuclear Information System (INIS)

    Roth, J.

    1976-01-01

    Blister formation in metals has been observed during bombardment with inert-gas ions in the energy range between 1 and 2000 keV at doses of about 10 17 to 10 19 cm -2 . The changes in surface topography and the erosion yields were mainly studied in the scanning electron microscope (SEM). Additionally the release of the implanted gas during blister formation was observed. Recently measurements on single crystals were performed determining simultaneously the implantation profile, the total amount of trapped ions, the depth distribution of the induced lattice damage and the thickness of the covers of the blisters. In several stages of the formation process of blisters the implanted layer was observed in the transmission electron microscope (TEM) showing the formation of gas bubbles. Using the results of all these measurements in this review an attempt is made to develop a model of blister formation combining the effects of hydrostatic pressure in the gas bubbles and lateral stress due to volume swelling. (author)

  6. [Application of blistering cupping].

    Science.gov (United States)

    Gu, Xingui; Chen, Zelin; Chen, Bo; Fan, Yihua; Chen, Xianghong

    2016-11-12

    Blistering cupping is special as eliminating wind and dampness as well as removing phlegm and blood stasis, and it achieves effects through suction. In this paper we reviewed relevant literature combined with clinical experience so as to summarize its operation attention through exploring the origin, mechanism and application. We divide the progress into the blistering period, the phlegm-stasis-eliminating period, and the escharosis period according to the changes of bubble and the things pulled out. Blistering cupping creates ways to eliminate concrete unhealthy influences through smoothing meridians and collaterals, such as phlegm and retained fluid, dampness and blood stasis. Thus chronic diseases are relieved. Also,we propose the rules of "blistering acupoints being related to disease location as well as the nature of acupoints and diseases". The therapy has been used to treat diseases of respiratory system, osteoarticular, skin and subcutaneous tissue, mental and behavioral disorders, and tumor, among which the effects of intractable diseases of respiratory and osteoarticular systems are definite. It deserves to be further explored and promoted.

  7. Commandra Blister Rust

    Science.gov (United States)

    David W. Johnson

    1986-01-01

    Commandra blister rust is a disease of hard pines that is caused by a fungus growing in the inner bark. The fungus (Cronartium commandrae Pk.) has a complex life cycle. It infects hard pines but needs an alternate host, an unrelated plant, to spread from one pine to another.

  8. A model for blister exfoliation

    International Nuclear Information System (INIS)

    Deb, S.K.; Sood, D.K.

    1983-01-01

    We describe a mechanism for exfoliation of blisters by taking into account the temperature rise of the blister cover due to the incident beam heating. The rise in temperature is calculated by solving the time dependent heat conduction equation. The exfoliation is initiated either by a local melting or by the reduction of material strength due to the temperature rise leading to rupture of the blister skin by the pressure of the gas in the blister cavity. We propose two types of exfoliation: peripheral and non-peripheral, depending on the blister size. This model agrees well with the various experimental results reported on blister exfoliation. It is argued that this thermally assisted exfoliation of blisters may render the first wall erosion by high energy helium flux more serious than considered hitherto, in an actual fusion reactor system. (author)

  9. AUTOIMMUNE EPIDERMAL BLISTERING DISEASES

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2013-11-01

    Full Text Available Autoimmune bullous skin diseases (ABDs are uncommon, potentially fatal diseases of skin and mucous membranes which are associated with deposits of autoantibodies and complement against distinct molecules of the epidermis and dermal/epidermal basement membrane zone (BMZ. These autoantibodies lead to a loss in skin molecular integrity, which manifests clinically as formation of blisters or erosions. In pemphigus vulgaris, loss of adhesion occurs within the epidermis. The pioneering work of Ernst H. Beutner, Ph.D. and Robert E. Jordon, M.D. confirmed the autoimmune nature of these diseases. Walter F. Lever, M.D. contributed significantly to our understanding of the histopathologic features of these diseases. Walter Lever, M.D. and Ken Hashimoto, M.D. contributed electron microscopic studies of these diseases, especially in pemphigus vulgaris and bullous pemphigoid. In bullous pemphigoid (BP, linear IgA bullous dermatosis, epidermolysis bullosa acquisita (EBA and dermatitis herpetiformis (DH, loss of adhesion takes place within or underneath the BMZ. Classic EBA demonstrates extensive skin fragility; DH is commonly associated with gluten-sensitive enteropathy, and manifests clinically with pruritic papulovesicles on the extensor surfaces of the extremities and the lumbosacral area. The clinical spectrum of bullous pemphigoid includes tense blisters, urticarial plaques, and prurigo-like eczematous lesions. Pemphigoid gestationis mostly occurs during the last trimester of pregnancy, and mucous membrane pemphigoid primarily involves the oral mucosa and conjunctivae and leads to scarring. Linear IgA bullous dermatosis manifests with tense blisters in a „cluster of jewels”-like pattern in childhood (chronic bullous disease of childhood and is more clinically heterogeneous in adulthood. Many of the autoantigens in these disorders are known and have been well characterized. ABDs may be influenced by both genetic and exogenous factors. The diagnoses of

  10. Blistering phenomena I: metals and alloys

    International Nuclear Information System (INIS)

    Kaminsky, M.; Das, S.K.

    1976-01-01

    A summary of the major parameters affecting the blistering process is given. Brief discussions of the blistering mechanisms are included. The following topics are described: (1) projectile-target system, (2) projectile energy, (3) critical dose for blister formation, (4) effect of total dose, (5) dose rate, (6) target temperature, (7) crystallographic orientation of the irradiated surface, (8) models for blister formation, and (9) surface erosion of fusion reactor components by blistering

  11. Radiation blistering of stainless steel

    International Nuclear Information System (INIS)

    Yoshii, Naritsugu; Tanabe, Tetsuo; Imoto, Shosuke

    1980-01-01

    Surface blistering of stainless steels due to 20 keV He + ion bombardment has been investigated by examination of surface topography with a scanning electron microscope (SEM) and an optical microscope. Blisters of 0.1 to 2 μm in diameter are observed in all samples irradiated with fluence of about 1 x 10 18 He + /cm 2 at any temperature between -80 0 C and 500 0 C. With increasing the fluence blister covers are ruptured and exfoliated and finally the surface becomes rough surface without traces of blister formation. The surface effect is severer at 500 0 C than at 100 0 C irradiation. Also in double-phase stainless steel DP-3, similar surface topography to 316 SS is observed. But by the difference of the erosion rate by sputtering of the surface between α-phase and γ-phase, a striped pattern appears in DP-3 with heavy irradiation of about 2 x 10 19 He + /cm 2 . (author)

  12. The Causes of Boat Hull Blisters

    Science.gov (United States)

    1987-05-01

    blistering. The report is divided into the following sections: Introduction; How Blisters Form; the Hull Material; Manufacturing Processes; Water Diffusion...Term Effects of Water Up-Takeo " The much more detailed and highly technical report of thia-Vsrk is entitled "The Causes of Blistering in Boat Building...Chemical Engineering, ably assisted by several graduate students, and was completed in the fall of 1986. The report itself, d List-ribution/_ Availabilit

  13. Radiation blistering in metals and alloys

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminsky, M.

    1975-01-01

    Radiation blistering in solids has been identified as a process leading to damage and erosion of irradiated surfaces. Some of the major parameters governing the blistering process in metals and some metallic alloys are the type of projectile and its energy, total dose, dose rate, target temperature, channeling condition of the projectile, orientation of the irradiated surface plane, and target material and its microstructure. Experimental results and models proposed for blister formation and rupture are reviewed. The blistering phenomenon is important as an erosion process in applications such as fusion reactor technology (plasma-wall interactions) and accelerator technology (erosion of components and targets). A description of methods for the reduction of surface erosion caused by blistering is included

  14. WHITE BLISTER SPECIES (Albuginaceae ON WEEDS

    Directory of Open Access Journals (Sweden)

    Karolina Vrandečić

    2011-06-01

    Full Text Available The obligate fungi inside the family Albuginaceae are widespread world wide and cause white rust or white blister disease. Mycopopulation of weeds has been researched within the project „The role of weeds in epidemiology of row-crop diseases“. The aim of this research was to identify white blister species occurring on weeds in Eastern Croatia. Weed plants with disease symptoms characteristic for white blister species have been collected since 2001 on location Slavonia and Baranja country. Determination of white blister species was based on morphological characters of pathogen and the host. Wilsoniana bliti was determined on Amaranthus retroflexus and Amaranthus hybridus leaves. Capsella bursa pastoris is a host for Albugo candida. Ambrosia artemisiifolia is a host for Pustula sp. and Cirsium arvense was found to be host for Pustula spinulosa. Wilsoniana portulaceae was determined on Portulaca oleracea.

  15. Microbiological Quality of Blister Pack Tablets in Community ...

    African Journals Online (AJOL)

    Keywords: Blister pack, Community pharmacy, Good Manufacturing Practice, Microbial contamination,. Quality control ... High levels of microbial contamination in blister-packed tablets ... and their drugs approved by the Jordan Food and Drug ...

  16. Antiplectin autoantibodies in subepidermal blistering diseases

    NARCIS (Netherlands)

    Buijsrogge, J. J. A.; de Jong, M. C. J. M.; Kloosterhuis, G. J.; Vermeer, M. H.; Koster, J.; Sonnenberg, A.; Jonkman, M. F.; Pas, H. H.

    2009-01-01

    Background Hemidesmosomal proteins may become targets of autoimmunity in subepidermal blistering diseases. Well-known recognized autoantigens are the intracellular plaque protein BP230, the transmembrane BP180 and its shed ecto-domain LAD-1. Objectives To establish the prevalence of autoimmunity

  17. Correlation of blister diameter and blister skin thickness in helium-ion-irradiated Nb

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminsky, M.; Fenske, G.

    1979-01-01

    A systematic study of the correlation between blister diameter and blister skin thickness has been performed for helium-ion irradiation of monocrystalline and polycrystalline Nb for ion energies ranging from 20 to 500 keV. The results indicate that a relationship Datsub mpatproportionaltatsup 1.50at between the most probable blister diameter, Datsub mpat, and blister skin thickness, t, which has been suggested by other authors, does not exist for the various types of Nb targets studied. For example, for room-temperature irradiation of annealed polycrystalline Nb the experimentally determined relationship is Datsub mpat<10.3tatsup 1.22at. Furthermore, the D-t relationship was found to depend on the irradiation temperature in contrast to theoretical predictions by the lateral stress model of blister formation. These results do not appear to support the lateral stress model which predicts the relationship Dproportionaltatsup 1.5at. However, the experimentally determined relationships can be explained in part by the gas pressure model of blister formation

  18. A computer model for hydride blister growth in zirconium alloys

    International Nuclear Information System (INIS)

    White, A.J.; Sawatzky, A.; Woo, C.H.

    1985-06-01

    The failure of a Zircaloy-2 pressure tube in the Pickering unit 2 reactor started at a series of zirconium hydride blisters on the outside of the pressure tube. These blisters resulted from the thermal diffusion of hydrogen to the cooler regions of the pressure tube. In this report the physics of thermal diffusion of hydrogen in zirconium is reviewed and a computer model for blister growth in two-dimensional Cartesian geometry is described. The model is used to show that the blister-growth rate in a two-phase zirconium/zirconium-hydride region does not depend on the initial hydrogen concentration nor on the hydrogen pick-up rate, and that for a fixed far-field temperature there is an optimum pressure-type/calandria-tube contact temperature for growing blisters. The model described here can also be used to study large-scale effects, such as hydrogen-depletion zones around hydride blisters

  19. Ion implantation induced blistering of rutile single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, Bing-Xi [School of Physics, Shandong University, Jinan, Shandong 250100 (China); Jiao, Yang [College of Physics and Electronics, Shandong Normal University, Jinan, Shandong 250100 (China); Guan, Jing [School of Physics, Shandong University, Jinan, Shandong 250100 (China); Wang, Lei [School of Physics, Shandong University, Jinan, Shandong 250100 (China); Key Laboratory of Nanodevices and Applications, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences (China)

    2015-07-01

    The rutile single crystals were implanted by 200 keV He{sup +} ions with a series fluence and annealed at different temperatures to investigate the blistering behavior. The Rutherford backscattering spectrometry, optical microscope and X-ray diffraction were employed to characterize the implantation induced lattice damage and blistering. It was found that the blistering on rutile surface region can be realized by He{sup +} ion implantation with appropriate fluence and the following thermal annealing.

  20. Reliable site for suction blister induction and harvesting

    Directory of Open Access Journals (Sweden)

    Laxmisha Chandrashekar

    2005-01-01

    Full Text Available Background: Suction blister grafting is a useful modality of treatment of patients with resistant and stable vitiligo. However, there have been no detailed studies to find out the best donor site for blister formation. Methods: The study was conducted between the period of October 2004 and February 2005 in the dermatology department at a tertiary care center. Nine patients with vitiligo (focal vitiligo, 3; mucosal vitiligo, 2; acrofacial vitiligo, 2; vitiligo vulgaris, 1; and segmental vitiligo, 1 were selected for blister harvesting and grafting. The blisters were raised using the method described by Gupta et al. Results: Suction blisters were attempted to be raised at 52 sites, but only 38 blisters could be raised, 24 complete and 14 incomplete. Blisters were raised in all the three cases on the flexor aspect of the arm (100%, 15 of 17 cases (88.2% on the flexor aspect of the forearm, 4 of 5 cases (80% on the abdomen, 11 of 16 cases (68.7% on the anterolateral thigh, and less frequently over leg or foot. Complete blisters were formed in 13/15 cases (86.6% on the flexor aspect of the forearm, 6/11 cases (54.5% on the anterolateral thigh, and in all cases over leg. Conclusion: The flexor aspect of the forearm is a good site for suction blister harvesting.

  1. Alpha transport and blistering in tokamaks

    International Nuclear Information System (INIS)

    Bauer, W.; Wilson, K.L.; Bisson, C.L.; Haggmark, L.G.; Goldston, R.J.

    1978-12-01

    The particle flux and angular distribution of 3.5 MeV alpha particles impinging on the first wall from uncontained banana orbits in an axisymmetric tokamak reactor have been calculated. The resulting helium concentration profiles in the first wall can give rise to surface exfoliation under specified conditions. The major mitigating factor is the simultaneous surface recession due to sputtering by the D-T charge exchange neutral flux. For the parameters used in these calculations blistering in high sputtering rate materials such as Be is unlikely whereas in low sputtering rate materials such as Nb, He induced surface deformation is quite probable

  2. Suction blister lesions and epithelialization monitored by optical coherence tomography

    DEFF Research Database (Denmark)

    Ahlström, M G; Gjerdrum, L M R; Larsen, H F

    2018-01-01

    suction blister was raised on each buttock, and the blister roof was excised. Lesions were covered with moisture-retaining dressing. In Study 1, the lesions were OCT-scanned on day 0 (D0), D2 and D4 and excised for histological examination. In Study 2, the progress of epithelialization and skin barrier...

  3. Frequency of comandra blister rust infection episodes on lodgepole pine

    Science.gov (United States)

    William R. Jacobi; Brian W. Geils; Jane E. Taylor

    2002-01-01

    Comandra blister rust is a damaging canker disease of lodgepole pine in the Central Rocky Mountains. Our knowledge of previous blister rust outbreaks and the effects of weather and climate on rust epidemiology has not been sufficient to explain the frequency and severity of disease outbreaks. Thus, we sought to describe the seasonal and annual frequency and duration of...

  4. White pines, blister rust, and management in the Southwest

    Science.gov (United States)

    D. A. Conklin; M Fairweather; D Ryerson; B Geils; D Vogler

    2009-01-01

    White pines in New Mexico and Arizona are threatened by the invasive disease white pine blister rust, Cronartium ribicola. Blister rust is already causing severe damage to a large population of southwestern white pine in the Sacramento Mountains of southern New Mexico. Recent detection in northern and western New Mexico suggests that a major expansion of the...

  5. Role of gas pressure and lateral stress on blistering

    International Nuclear Information System (INIS)

    Wolfer, W.G.

    1980-04-01

    Both gas pressure in bubbles and lateral stress have been suggested as primary causes of blistering. An analysis of both mechanisms is presented, and the conditions for blistering are examined. To realistically predict the gas pressure in bubbles, a recently derived high-density equation of state for helium is utilized

  6. Deuterium ion irradiation induced blister formation and destruction

    Energy Technology Data Exchange (ETDEWEB)

    Song, Jaemin; Kim, Nam-Kyun; Kim, Hyun-Su; Jin, Younggil; Roh, Ki-Baek; Kim, Gon-Ho, E-mail: ghkim@snu.ac.kr

    2016-11-01

    Highlights: • The areal number density of blisters on the grain with (1 1 1) plane orientation increased with increasing ion fluence. • No more blisters were created above the temperature about 900 K due to high thermal mobility of ions and inactivity of traps. • The destruction of blister at the boundary induced by sputtering is proposed. • The blisters were destructed at the position about the boundary by high sputtering yield of oblique incident ions and thin thickness due to plastic deformation at the boundary. - Abstract: The blisters formation and destruction induced by the deuterium ions on a polycrystalline tungsten were investigated with varying irradiation deuterium ion fluence from 3.04 × 10{sup 23} to 1.84 × 10{sup 25} D m{sup −2} s{sup −1} and an fixed irradiated ion energy of 100 eV in an electron cyclotron resonance plasma source, which was similar to the far-scrape off layer region in the nuclear fusion reactors. Target temperature was monitored during the irradiation. Most of blisters formed easily on the grain with (1 1 1) plane orientation which had about 250 nm in diameter. In addition, the areal number density of blisters increased with increasing the ion fluence under the surface temperature reaching to about 900 K. When the fluence exceeded 4.6 × 10{sup 24} D m{sup −2}, the areal number density of the blister decreased. It could be explained that the destruction of the blister was initiated by erosion at the boundary region where the thickness of blister lid was thin and the sputtering yield was high by oblique incident ions, resulting in remaining the lid open, e.g., un-eroded center dome. It is possible to work as a tungsten dust formation from the plasma facing divertor material at far-SOL region of fusion reactor.

  7. Is cupping blister harmful?-A proteomical analysis of blister fluid induced by cupping therapy and scald.

    Science.gov (United States)

    Liu, Zhidan; Chen, Chunlan; Li, Xiaoyan; Zhao, Chuang; Li, Zunyuan; Liang, Wei; Lin, Yufang

    2018-02-01

    Cupping therapy has a long history in traditional medicine especially in Asian countries. It was controversial whether cupping induced blisters are beneficial to healing effects, and the formation and content in the blisters remain unexplored. We aimed to identify and compare the molecular components of the blister fluid from the cupping therapy and the scalds to explore the necessary of inducing cupping induced blisters. Fluid sample of blisters from fifteen patients receiving cupping therapy (Cupping group) and scald burns (Scald group) were collected in this study. Proteins from the blisters were separated by two-dimensional electrophoresis (2D-gel) and further analyzed by mass spectrometry. In addition, the changes in particular proteins were confirmed by Western blotting. The protein components are significantly different between blister from cupping therapy and scalds. The immune responses, oxidative stress and metabolic related proteins (Ig lambda-2 chain C regions, Ig gamma-1 chain C region, hemopexin, prdx2, calmodulin, succinyl-CoA ligase and tetranectin) were increased, whereas the hemoglobin subunit beta was decreased in the Cupping group compared with the Scald group. Cupping induced blisters contain several proteins which relate to the activation of certain immune pathways including anti-oxidation, anti-apoptosis, tissue repairing and metabolic regulation. This proteomic analysis may indicate a significant clue to the mechanism study of cupping. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. The ‘Sticky Elastica’: delamination blisters beyond small deformations

    KAUST Repository

    Wagner, Till J. W.; Vella, Dominic

    2013-01-01

    We consider the form of an elastic loop adhered to a rigid substrate: the 'Sticky Elastica'. In contrast to previous studies of the shape of delamination 'blisters', the theory developed accounts for deflections with large slope (i.e. geometrically

  9. Surface roughness effects on blister formation in polycrystalline molybdenum

    International Nuclear Information System (INIS)

    Saidoh, Masahiro; Sone, Kazuho; Yamada, Rayji; Ohtsuka, Hidewo; Murakami, Yoshio

    1977-07-01

    Polycrystalline molybdenum targets with electropolished and roughened surfaces were bombarded with 100 keV He + and 200 keV H 2 + ions at room temperature. It has been demonstrated that the blister formation is largely or completely suppressed by roughening the electropolished surface with emery paper of No. 1200, No. 400 and No. 100. Up to a He + fluence of 1.0 x 10 19 particles/cm 2 , no blisters are observed in the targets with the two roughest surfaces, while on the smooth surface blisters begin to occur at a fluence of 7.5 x 10 17 particles/cm 2 . The surface roughness effect on blister suppression is discussed in relation to the projected range of incident particles. (auth.)

  10. Suction blister grafting - Modifications for easy harvesting and grafting

    Directory of Open Access Journals (Sweden)

    2012-01-01

    Full Text Available Suction blister grafting is a simple modality of treatment of patients with resistant and stable vitiligo. But raising the blisters may be time consuming and transferring to the recipient site may be difficult as the graft is ultrathin. By doing some modifications we can make the technique simpler and easier. We can decrease the blister induction time by intradermal injection of saline, exposure to Wood′s lamp, intrablister injection of saline. By these methods we can decrease the blister induction time from 2-3 hrs to 45-90 minutes. After harvesting the graft, it can be transferred to the recipient area by taking the graft on a sterile glass slide, on the gloved finger, rolling the graft over a sterile syringe and then spreading on the recipient area, or taking on the sterile wrapper of paraffin dressing and then placing over the recipient area.

  11. Helium-induced blistering and volume swelling in nickel

    International Nuclear Information System (INIS)

    Fenske, G.R.

    1980-01-01

    The results of an experimental investigation of helium-induced blistering are presented. The goal of the research was to examine the mechanisms involved in blistering by observing the microstructure of the implanted region using transmission electron microscopy (TEM). In particular, the volume swelling was measured as a function of the implant depth, and compared to experimental skin thicknesses in order to determine if the skin separated at the maximum volume swelling, or at the end of the swelling profile

  12. Flaking and blistering on He and Ne bombardments

    International Nuclear Information System (INIS)

    Kamada, K.; Naramoto, H.

    1979-01-01

    Large scale exfoliation formed by 300 keV He + bombardment of niobium without any preceding blistering is investigated, in comparison with the blistering due to 450 and 850 keV Ne + bombardments. In-situ observations of the erosion processes were performed in a scanning electron microscope connected to the Van de Graaff. Critical doses of 7.2 x 10 17 He + /cm 2 , 2.4 x 10 17 Ne + /cm 2 and 4.0 x 10 17 Ne + /cm 2 were obtained for the 300 keV He flaking, 450 keV Ne blistering and 850 keV Ne blistering, respectively. The He flaking was presumed to be due to brittle fashion peeling-off of the surface layer by the bending moment driven by the internal gas pressure. The blistering, on the other hand, was presumed to be the result of the ductile fashion spreading of the lenticular bubble in the sub-surface layer. The necessary pressure for the peeling-off of the cover was calculated, and was speculated to be able to work as the driving force for the flaking from its unexpectedly low values. Fractographies under the exfoliations were discussed for both flaking and blistering. (author)

  13. The significance of a correlation of blister diameter with skin thickness for Ni and Be for blistering models

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminsky, M.; Fenske, G.

    1978-01-01

    It has been suggested that large lateral stresses introduced in an ion implanted surface layer may cause elastic instability and buckling of the implant layer (blister formation), and result in a relationship Dsub(mp) proportional to tsup(3/2) between the most probable blister diameter Dsub(mp) and the blister skin thickness, t, for metals such as Be, V, stainless steel, Nb and Mo. To test this relationship a systematic study of the correlation between blister diameter and skin thickness for helium blistering of annealed polycrystalline Ni and Be has been conducted for helium ion energies in the range of 15-300 keV. For beryllium the relationship between Dsup(mp) (μm) and t(μm) can be fitted by the expression Dsub(mp)=24.6tsup(1.25) whereas for nickel a best fit is obtained for the expression Dsub(mp)=1.24tsup(1.5). These results, together with earlier results for Nb and V show that the relationship between Dsub(mp) and t is stronly dependent on the type of metal studied and do not support the lateral stress model for blister formation. (Auth.)

  14. The ‘Sticky Elastica’: delamination blisters beyond small deformations

    KAUST Repository

    Wagner, Till J. W.

    2013-01-01

    We consider the form of an elastic loop adhered to a rigid substrate: the \\'Sticky Elastica\\'. In contrast to previous studies of the shape of delamination \\'blisters\\', the theory developed accounts for deflections with large slope (i.e. geometrically nonlinear). Starting from the classical Euler Elastica we provide numerical results for the dimensions of such blisters for a variety of end-end confinements and develop asymptotic expressions that reproduce these results well, even up to the point of self-contact. Interestingly, we find that the width of such blisters does not grow monotonically with increased confinement. Our theoretical predictions are confirmed by simple desktop experiments and suggest a new method for the measurement of the elastocapillary length for deformations that cannot be considered small. We discuss the implications of our results for applications such as flexible electronics. © 2013 The Royal Society of Chemistry.

  15. Characterization of Blistering and Delamination in Depleted Uranium Hohlraums

    Energy Technology Data Exchange (ETDEWEB)

    Biobaum, K. J. M.

    2013-03-01

    Blistering and delamination are the primary failure mechanisms during the processing of depleted uranium (DU) hohlraums. These hohlraums consist of a sputter-deposited DU layer sandwiched between two sputter-deposited layers of gold; a final thick gold layer is electrodeposited on the exterior. The hohlraum is deposited on a copper-coated aluminum mandrel; the Al and Cu are removed with chemical etching after the gold and DU layers are deposited. After the mandrel is removed, blistering and delamination are observed on the interiors of some hohlraums, particularly at the radius region. It is hypothesized that blisters are caused by pinholes in the copper and gold layers; etchant leaking through these holes reaches the DU layer and causes it to oxidize, resulting in a blister. Depending on the residual stress in the deposited layers, blistering can initiate larger-scale delamination at layer interfaces. Scanning electron microscopy indicates that inhomogeneities in the machined aluminum mandrel are replicated in the sputter-deposited copper layer. Furthermore, the Cu layer exhibits columnar growth with pinholes that likely allow etchant to come in contact with the gold layer. Any inhomogeneities or pinholes in this initial gold layer then become nucleation sites for blistering. Using a focused ion beam system to etch through the gold layer and extract a cross-sectional sample for transmission electron microscopy, amorphous, intermixed layers at the gold/DU interfaces are observed. Nanometer-sized bubbles in the sputtered and electrodeposited gold layers are also present. Characterization of the morphology and composition of the deposited layers is the first step in determining modifications to processing parameters, with the goal of attaining a significant improvement in hohlraum yield.

  16. Psychosocial impact of inherited and autoimmune blistering diseases

    Directory of Open Access Journals (Sweden)

    Swaranjali V. Jain, B Med Sci (Hons MD

    2018-03-01

    Full Text Available Inherited and autoimmune blistering diseases are rare, chronic, and often severe disorders that have the potential to significantly affect patients’ quality of life. The effective management of these conditions requires consideration of the physical, emotional, and social aspects of the disease. Self-esteem is integral to patients’ ability to cope with their illness, participate in treatment, and function in society. This article discusses quality-of-life studies of patients with blistering diseases with a particular focus on self-esteem issues that patients may face.

  17. Exposure to a First World War blistering agent.

    Science.gov (United States)

    Le, H Q; Knudsen, S J

    2006-04-01

    Sulfur mustards act as vesicants and alkylating agents. They have been used as chemical warfare since 1917 during the first world war. This brief report illustrates the progression of injury on a primary exposed patient to a first world war blistering agent. This case documents the rapid timeline and progression of symptoms. It emphasises the importance of appropriate personal protective equipment and immediate medical response plan with rapid decontamination and proper action from military and civilian medical treatment facilities. This case reports the first US active duty military exposure to a blistering agent in the age of global terrorism.

  18. A case showing a blistering disorder in radiation dermatitis during radiation therapy

    International Nuclear Information System (INIS)

    Nonoshita, Takeshi; Nakamura, Katsumasa; Shioyama, Yoshiyuki

    2007-01-01

    We experienced a case showing a blistering disorder in radiation dermatitis during radiation therapy for thymic cancer. Application of steroid to the lesion improved blisters. The literature on bullous eruption including radiation-induced bullous pemhigoid was critically reviewed. (author)

  19. Antibiotic Treatment of Blister Rust Cankers in Eastern White Pine

    Science.gov (United States)

    William R. Phelps; Ray Weber

    1970-01-01

    Cycloheximide (Acti-dione) and Phytoactin antibiotics, applied as basal stem treatments, aerial spray treatments, and complete foliar drenches were not effective in controlling blister rust cankers in eastern white pine. Cycloheximide was effective in suppressing canker activity and growth if directly applied to scarified cankers.

  20. Blister rust control in the management of western white pine

    Science.gov (United States)

    Kenneth P. Davis; Virgil D. Moss

    1940-01-01

    The forest industry of the western white pine region depends on the production of white pine as a major species on about 2,670,000 acres of commercial forest land. Continued production of this species and maintenance of the forest industry at anything approaching its present level is impossible unless the white pine blister rust is controlled. Existing merchantable...

  1. Resistance of three interspecific white pine hybrids to blister rust

    Science.gov (United States)

    R. Z. Callaham

    1962-01-01

    Three white pine hybrids exposed to infection by white pine blister rust (Cronartium ribicola Fischer) since 1946 have inherited the relative resistance of their parental species. The hybrids were produced from controlled pollinations in 1940 and 1941 at the Institute of Forest Genetics, Placerville, Calif. Twelve seedlings of each hybrid were...

  2. Characteristics of Blister Rust Cankers on Eastern White Pine

    Science.gov (United States)

    William R. Phelps; Ray Weber

    1969-01-01

    The growth, development, and sporulation of white pine blister rust cankers were studied on eastern white pine in Wisconsin and Minnesota. Three district canker types were identified on the basis of physical appearance, growth rate, and sporulation. Canker growth rate and sporulation decreased as tree size or age increased, and many cankers apparently became inactive...

  3. Microbiological Quality of Blister Pack Tablets in Community ...

    African Journals Online (AJOL)

    Methods: A total of 66 items of 22 registered blister-packed tablet brands were purchased from community pharmacies in Amman. All the items were investigated for total bacterial count and the presence of specified microorganisms using compendial procedures. Results: Out of 66 items purchased, forty eight (72.7 ...

  4. Hydride blister formation simulation in Candu type reactors

    International Nuclear Information System (INIS)

    Otero, D.; Bollini, C.; Sangregorio, D.

    1992-01-01

    We have developed a computer code for the probability study of hydride blister formation in pressure tubes named BLIFO. The basic hypothesis of the model are: the pressure tube is divided into five areas according to the existence of four garter springs. For each area the probability of blister formation is the probability of the hydrogen content exceeding a critical threshold when contact tube is present; the probability of a blister in a tube is the OR combination of the probabilities of a blister in each area; the tube contact is a function of the garter springs location, and the time; the critical hydrogen threshold is sorted over the areas within the pressure tube; hydrogen pick-up rate was sorted with a Gaussian distribution; the initial hydrogen content values for each tube were measured before the ensamble and they are used in the code. For Embalse evaluation, we build up a subroutine that simulate Gaussian distribution using the parameters of a typical nuclear power Candu reactor garter spring distribution. (author)

  5. White pine blister rust resistance research in Minnesota and Wisconsin

    Science.gov (United States)

    Andrew David; Paul Berrang; Carrie Pike

    2012-01-01

    The exotic fungus Cronartium ribicola causes the disease white pine blister rust on five-needled pines throughout North America. Although the effects of this disease are perhaps better known on pines in the western portion of the continent, the disease has also impacted regeneration and growth of eastern white pine (Pinus strobus L. ...

  6. White pines, Ribes, and blister rust: integration and action

    Science.gov (United States)

    R. S. Hunt; B. W. Geils; K. E. Hummer

    2010-01-01

    The preceding articles in this series review the history, biology and management of white pine blister rust in North America, Europe and eastern Asia. In this integration, we connect and discuss seven recurring themes important for understanding and managing epidemics of Cronartium ribicola in the white pines (five-needle pines in subgenus Strobus). Information and...

  7. White pines, Ribes, and blister rust: a review and synthesis

    Science.gov (United States)

    Brian W. Geils; Kim E. Hummer; Richard S. Hunt

    2010-01-01

    For over a century, white pine blister rust (Cronartium ribicola) has linked white pines (Strobus) with currants and gooseberries (Ribes) in a complex and serious disease epidemic in Asia, Europe, and North America. Because of ongoing changes in climate, societal demands for forests and their amenities, and scientific advances in genetics and proteomics, our current...

  8. White pine blister rust in the interior Mountain West

    Science.gov (United States)

    Kelly Burns; Jim Blodgett; Dave Conklin; Brian Geils; Jim Hoffman; Marcus Jackson; William Jacobi; Holly Kearns; Anna Schoettle

    2010-01-01

    White pine blister rust is an exotic, invasive disease of white, stone, and foxtail pines (also referred to as white pines or five-needle pines) in the genus Pinus and subgenus Strobus (Price and others 1998). Cronartium ribicola, the fungus that causes WPBR, requires an alternate host - currants and gooseberries in the genus Ribes and species of Pedicularis...

  9. Helium-induced blistering and volume swelling in nickel

    International Nuclear Information System (INIS)

    Fenske, G.R.

    1979-01-01

    The results of an experimental investigation of He-induced blistering are presented. The mechanisms involved in blistering were examined by observing the microstructure of the implanted region using TEM. The volume swelling was measured as a function of the implant depth. The investigation revealed factors important in understanding the mechanisms involved in blister formation. First, a direct comparison of measured skin-thicknesses with the location of the maximum volume swelling demonstrated that the skin separates at the peak swelling depth, not at the end of the swelling profile. Second, an examination of the assumptions that have been used to predict skin-thicknesses revealed that the differences between predicted and measured skin thicknesses at low energies can be attributed to: failure to account for volume swelling in the skin, using a Gaussian approximation to the range profile, or one generated with a Monte-Carlo code, and uncertainties in the electronic stopping powers. Beyond a certain dose, the density of cavities in the peak-swelling region decreased with increasing dose; indicating that cavity coalescence does occur. A calculation of the He concentration required to fracture the load-bearing cross section between the cavities revealed that a sufficient quantity of He was available to generate the required gas pressures. These observations indicate that models based on coalescence followed by gas-driven deformation provide an accurate description of the mechanisms involved in blistering; and they can accurately predict skin thicknesses at low energies

  10. HOW TO Identify White Pine Blister Rust and Remove Cankers

    Science.gov (United States)

    Thomas H. Nicholls; Robert L. Anderson

    1977-01-01

    White pine blister rust (caused by the fungus Cronartium ribicola J. C. Fisch. ex Rabenh.) was introduced into the United States about 1900 and has since spread throughout the range of white pine. The disease intensity varies throughout the range but is normally most severe where late summers (July-September) are cool (below 67? F) and damp, conditions necessary for...

  11. Radiation blistering in Inconel-625 due to 100 KeV helium ion irradiation

    International Nuclear Information System (INIS)

    Whitton, J.L.; Rao, A.S.; Kaminsky, M.

    1988-01-01

    The objective of this study was to determine whether the change of angle of incidence of an ion beam impinging on surface blisters during their growth phase (before exfoliation) could influence the blister skin thickness and the blister crater depth. Polished, polycrystalline Inconel-625 samples were irradiated at room temperature and at normal incidence to the major sample surface with 100 keV helium ions to a total dose of 6.24x10 18 ions/cm 2 . The results revealed that many exfoliated blisters leave craters which have two or three concentric pits. The blister skin thickness near the center of the blister was found to agree well with the calculated projected range of 100 keV He ions in nickel. However, the blister skin thickness of some exfoliated blisters along the edge of the fracture surface showed different thicknesses. A model is proposed to explain the observed blister crater/blister fracture features in terms of a change of angle of incidence of the incident ions to the surface during the growth phase of surface blisters. (orig.)

  12. Influence of external action and structural factors on radiation blistering

    International Nuclear Information System (INIS)

    Kalin, B.A.; Chernov, I.I.; Fomina, E.P.; Korshunov, S.H.; Polsky, V.I.; Skorov, D.M.; Yakushin, V.L.

    1985-01-01

    A survey of experimental results is presented, pertaining to radiation blistering of a considerable number of materials (stainless steels, alloys with high nickel content, alloys of refractory metals) under helium ion irradiation with energies of 20-100 keV under conditions corresponding to the plasma-wall interaction: bombardment at various angles of incidence and cyclic irradiation in a wide spectrum of ion incidence angles; influence of external action, including thermocyclic; influence of preceding neutron and proton irradiation. It has been shown that external factors have a complex influence on blister parameters and erosion coefficients of materials. A study has been carried out on the influence of aluminium coatings, alloying additions, phase state of material and microstructure on the nature and degree of surface erosion. Complex influence of element and phase composition, as well as microstructural changes during heat treatment and welding on radiation erosion have been established. (orig.)

  13. Diagnostic pitfalls in newborns and babies with blisters and erosions.

    Science.gov (United States)

    Nischler, Elke; Klausegger, Alfred; Hüttner, Clemens; Pohla-Gubo, Gabriele; Diem, Anja; Bauer, Johann W; Hintner, Helmut

    2009-01-01

    Establishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic) and inherited disorders have to be taken into consideration. Similarities in clinical appearance, colonization and/or superinfections of preexisting skin lesions, as well as the absence of late changes in the neonate often pose significant diagnostic challenges. In this paper we discuss by giving examples the process of making an accurate diagnosis of blistering skin diseases in the neonatal period on the basis of a diagnostic algorithm. In addition, we provide an overview of the rational use and the limitations of laboratory procedures such as microbial testing, routine light microscopy, immunofluorescence antigen mapping, transmission electron microscopy, and molecular genetic analysis.

  14. Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions

    Directory of Open Access Journals (Sweden)

    Elke Nischler

    2009-01-01

    Full Text Available Establishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic and inherited disorders have to be taken into consideration. Similarities in clinical appearance, colonization and/or superinfections of preexisting skin lesions, as well as the absence of late changes in the neonate often pose significant diagnostic challenges. In this paper we discuss by giving examples the process of making an accurate diagnosis of blistering skin diseases in the neonatal period on the basis of a diagnostic algorithm. In addition, we provide an overview of the rational use and the limitations of laboratory procedures such as microbial testing, routine light microscopy, immunofluorescence antigen mapping, transmission electron microscopy, and molecular genetic analysis.

  15. Coulomb explosion sputtering, crater and blister formation by HCI

    International Nuclear Information System (INIS)

    Parilis, E.S.

    2001-01-01

    A simple theoretical model based on gradual Auger neutralization of a highly charged ion as it approaches the surface, with consequent positive charge deposition in surface layers and their expansion due to Coulomb repulsion provides the means to make some estimates that could explain the creation of very shallow blisters and craters on surface, as well as sputtering of up to 10 3 atoms in a single ion impact. Calculation of the dependence of blister size on projectile charge, based on charge evolution, gives some results fitting the experimental data. The model deals not just with the conducting properties of the solid, but with its structure as well, for instance the layered structure of mica. While the general source of energy remains the same, the particular mechanism of its realization depends largely on the composition, structure and electronic properties of the solid. The composition of the ejecta is discussed within the framework of the shock wave approach. (orig.)

  16. Simulation of hydrogen migration and blisters formation in zirconium alloys

    International Nuclear Information System (INIS)

    Saliba, R.O.

    1991-06-01

    The phenomenon of hydrogen migration and hydride blister growth after pressure tube/calandria tube contact in CANDU reactors is addressed. This phenomenon is by now regarded as an important factor limiting reactors lifetime, since it originated Pickering incident in 1983. Numerical results of thermally-assisted diffusion in excellent agreement with quasi-analytical solutions of the mathematical model were obtained. A sensitivity analysis was performed to assess the accuracy of these results. Some two-dimensional calculations are also included to demonstrate the capabilities of the numerical methods. The main outcomes of the work are the following: a through understanding of the mathematics and physics involved in hydrogen migration under thermal gradients. The validation of a numerical procedure based on a regularization of the constitutive equations. Blister growth rates in slab geometries for initial concentrations that span the full range of technological interest. Some preliminary two-dimensional results allow the design of future developments. (Author) [es

  17. Contact Burn with Blister Formation in Children Treated with Sennosides.

    Science.gov (United States)

    Cogley, Kimberly; Echevarria, Andrea; Correa, Catalina; De la Torre-Mondragón, Luis

    2017-03-01

    Eight children treated for severe constipation with sennosides unexpectedly developed contact burns with blisters secondary to the use of these laxatives. All patients wore diapers, and the injuries occurred overnight. To avoid this side effect, we recommend that patients treated with sennosides, especially those in diapers, receive the medication at a time that allows for bowel movements to occur during the day and not overnight. © 2017 Wiley Periodicals, Inc.

  18. Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions

    OpenAIRE

    Elke Nischler; Alfred Klausegger; Clemens Hüttner; Gabriele Pohla-Gubo; Anja Diem; Johann W. Bauer; Helmut Hintner

    2009-01-01

    Establishing the correct diagnosis in newborns presenting with blisters and erosions is not always a straightforward process. Many different disease entities including acquired (i.e., infectious, immunobullous, traumatic) and inherited disorders have to be taken into consideration. Similarities in clinical appearance, colonization and/or superinfections of preexisting skin lesions, as well as the absence of late changes in the neonate often pose significant diagnostic challenges. In this pape...

  19. The effect of autoimmune blistering diseases on work productivity.

    Science.gov (United States)

    Wang, E Q; Radjenovic, M; Castrillón, M A; Feng, G H Y; Murrell, D F

    2018-05-06

    Autoimmune blistering diseases (AIBD) are known to negatively impact upon quality of life (QoL); however, there is a paucity of research on the effect of AIBD on work productivity. AIBD can be quite disfiguring in terms of a patient's appearance due to their blistering nature. To determine the impact of AIBD on work productivity and to determine whether patients are stigmatized at work due to their appearance. Sixty-one patients with AIBD completed the Work Productivity and Activity Impairment Questionnaire-Specific Health Problem (WPAIQ-SHP), the Dermatology Life Quality Index (DLQI), the Autoimmune Bullous Disease Quality of Life (ABQOL) and the Treatment of Autoimmune Bullous Disease Quality of Life questionnaires (TABQOL). Non-responders to treatment had more work and activity impairment compared to responders. Worse WPAIQ-SHP scores were correlated with higher ABQOL, TABQOL and DLQI scores. Approximately 14.8% of subjects experienced stigmatization at work due to their appearance. The most common body areas stigmatized were easily visible sites, particularly the hands, arms and feet, with the majority of occurrences related to co-workers; for some patients, this stigmatization occurred on a daily basis. Loss of productivity at work was statistically much higher in those with higher disease severity, ABQOL & TABQOL scores and in non-responders to treatment. Autoimmune blistering diseases negatively impacts upon work productivity and activity. Stigmatization was common in the workplace which leads to increased stress, itself a stimulator of pemphigus. © 2018 European Academy of Dermatology and Venereology.

  20. Studies of radiation blistering effects on voltage holding

    International Nuclear Information System (INIS)

    Miley, G.H.

    1975-01-01

    The surfaces of niobium and tungsten wires were blistered by 300-keV helium-ion irradiation and then tested for voltage holding. A cylindrical projection-tube technique was employed so that regions of strong electron emission could be observed and later examined with a scanning electron microscope (SEM). Blistering was found to cause significant increases in pre-breakdown currents. However, these currents tend to saturate over a region corresponding to around 200-400 kV/cm surface field such that the ultimate voltage breakdown limit is not seriously reduced. Emission image observations and SEM photographs suggest that, in many cases, parts of the blistered surface are gradually erected by the strong surface fields, but this may not occur until after several arc breakdowns. SEM photographs also indicate that vapor from the anode may play an important part in the breakdown mechanism. Implications of these results to the design of devices important to fusion development, such as direct collectors and ion sources, are briefly discussed. The importance of future in situ irradiation-voltage experiments is also stressed. (U.S.)

  1. An investigation of two-level fracture in the blistering of D+ irradiated Cu

    International Nuclear Information System (INIS)

    Johnson, P.B.; Jones, W.R.

    1984-01-01

    The blisters produced by 200 keV D + irradiation of Cu at 120 K and subsequent heating to room temperature are found to be of two distinct types: small semi-spherical blisters and large blister flakes. A simple method has been developed to remove blister flakes enabling direct observation of the exposed underside of the flakes by scanning electron microscopy. The small semi-spherical blisters, which form before the more extensive blister flakes, have a consistently deeper plane of fracture than the flakes. To explain the different depths of fracture two alternative models are proposed. Compressional stress may inhibit bubble nucleation and early growth near the depth region around the maxima in the damage and gas deposition profiles. It is proposed that in the later stages of the irradiation shear introduced by differential expansion, caused by a combination of radiation induced swelling and localised heating plays a central role in fracture. (orig./RK)

  2. Determining the feasibility of objective adherence measurement with blister packaging smart technology.

    Science.gov (United States)

    van Onzenoort, Hein A; Neef, Cees; Verberk, Willem W; van Iperen, H Peter; de Leeuw, Peter W; van der Kuy, Paul-Hugo M

    2012-05-15

    The results of a feasibility study of blister-pack smart technology for monitoring medication adherence are reported. Research in the area of objective therapy compliance measurement has led to the development of microprocessor-driven systems that record the time a unit dose is removed from blister packaging. One device under development is the Smart Blister-a label imprinted with event-detection circuitry that can be affixed to standard commercial blister cards. In the first trial of the device in actual clinical practice, 115 community-dwelling Dutch patients receiving valsartan maintenance therapy (160 mg once daily) were given 14-day blister packages equipped with the Smart Blister. On the return of empty blister cards to the 20 participating community pharmacies, the stored information was scanned and downloaded for data analysis and patient counseling purposes. A total of 245 Smart Blister-equipped packages were used by valsartan recipients during the eight-month study. The device was largely effective in recording patient and blister-card identification data and other desired information. However, in 17% of cases, the Smart Blister system registered multiple tablet-removal events at the same time, presumably indicating unintentional breakage of nearby conductive circuits and the need for design refinements. The Smart Blister-equipped medication cards were generally well received by patients and pharmacies. An evaluation of the functionality and robustness of the Smart Blister in a real-world clinical practice situation yielded some promising results, but the findings also indicated a need for design refinements and additional performance testing of the device.

  3. Accumulation and release of implanted hydrogen from blisters in Si during the thermal treatment

    International Nuclear Information System (INIS)

    Aleksandrov, P.A.; Baranova, E.K.; Baranova, I.V.; Budaragin, V.V.; Litvinov, V.L.

    2004-01-01

    The processes of accumulation of ion implanted hydrogen in blisters in silicon and its release during the thermal treatment at 350-1020 deg C have been studied by optical techniques. It is established that accumulation of gaseous hydrogen inside blisters takes place at temperatures lower than ∼ 450-500 deg C and is accompanied by the growth of blisters thickness and deformation of their caps. At higher temperatures hydrogen leaves cavities and dissolves in silicon. Due to internal pressure dropping the elasticity deformed top layer partially relaxes, and the blister thickness decreases. Etching of the surface layer reveals the agglomerations of small voids ( [ru

  4. Multi-scale characterization of surface blistering morphology of helium irradiated W thin films

    International Nuclear Information System (INIS)

    Yang, J.J.; Zhu, H.L.; Wan, Q.; Peng, M.J.; Ran, G.; Tang, J.; Yang, Y.Y.; Liao, J.L.; Liu, N.

    2015-01-01

    Highlights: • Multi-scale blistering morphology of He irradiated W film was studied. • This complex morphology was first characterized by wavelet transform approach. - Abstract: Surface blistering morphologies of W thin films irradiated by 30 keV He ion beam were studied quantitatively. It was found that the blistering morphology strongly depends on He fluence. For lower He fluence, the accumulation and growth of He bubbles induce the intrinsic surface blisters with mono-modal size distribution feature. When the He fluence is higher, the film surface morphology exhibits a multi-scale property, including two kinds of surface blisters with different characteristic sizes. In addition to the intrinsic He blisters, film/substrate interface delamination also induces large-sized surface blisters. A strategy based on wavelet transform approach was proposed to distinguish and extract the multi-scale surface blistering morphologies. Then the density, the lateral size and the height of these different blisters were estimated quantitatively, and the effect of He fluence on these geometrical parameters was investigated. Our method could provide a potential tool to describe the irradiation induced surface damage morphology with a multi-scale property

  5. Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease.

    Science.gov (United States)

    Wada, Taizo; Toma, Tomoko; Miyazawa, Hanae; Koizumi, Eiko; Shirahashi, Tetsujiro; Matsuda, Yusuke; Yachie, Akihiro

    2018-04-01

    Epstein-Barr virus (EBV)-associated T- or natural killer (NK)-cell lymphoproliferative disease (LPD) is a heterogeneous group of disorders characterized by chronic proliferation of EBV-infected lymphocytes. Patients may present with severe skin manifestations, including hypersensitivity to mosquito bites (HMB) and hydroa vacciniforme (HV)-like eruption, which are characterized by blister formation and necrotic ulceration. Skin biopsy specimens show inflammatory reactions comprising EBV-infected lymphocytes. However, blister fluids have not been fully assessed in patients with this disease. Blister fluids were collected from three patients with EBV-associated LPD: two with HMB and one with HV. Immunophenotyping of blister lymphocytes and measurement of tumor necrosis factor (TNF)-α in blister fluids were performed. The patients with HMB and HV exhibited markedly increased percentages of NK and γδ T cells, respectively, in both peripheral blood and blister fluids. These NK and γδ T cells strongly expressed the activation marker human leukocyte antigen-DR and were considered to be cellular targets of EBV infections. TNF-α was highly elevated in all blister fluids. Severe local skin reactions of EBV-associated LPD may be associated with infiltrating EBV-infected lymphocytes and a high TNF-α concentration in blister fluids. © 2018 Japanese Dermatological Association.

  6. Current and future molecular approaches to investigate the white pine blister rust pathosystem

    Science.gov (United States)

    B. A. Richardson; A. K. M. Ekramoddoulah; J.-J. Liu; M.-S. Kim; N. B. Klopfenstein

    2010-01-01

    Molecular genetics is proving to be especially useful for addressing a wide variety of research and management questions on the white pine blister rust pathosystem. White pine blister rust, caused by Cronartium ribicola, is an ideal model for studying biogeography, genetics, and evolution because: (1) it involves an introduced pathogen; (2) it includes multiple primary...

  7. Strategies for managing whitebark pine in the presence of white pine blister rust [Chapter 17

    Science.gov (United States)

    Raymond J. Hoff; Dennis E. Ferguson; Geral I. McDonald; Robert E. Keane

    2001-01-01

    Whitebark pine (Pinus albicaulis) is one of many North American white pine species (Pinus subgenus Strobus) susceptible to the fungal disease white pine blister rust (Cronartium ribicola). Blister rust has caused severe mortality (often reaching nearly 100 percent) in many stands of white bark pine north of 45° latitude in western North America. The rust is slowly...

  8. Hydrides blister formation and induced embrittlement on zircaloy-4 cladding tubes in reactivity initiated conditions

    International Nuclear Information System (INIS)

    Hellouin-De-Menibus, A.

    2012-01-01

    Our aim is to study the cladding fracture with mechanical tests more representative of RIA conditions, taking into account the hydrides blisters, representative strain rates and stress states. To obtain hydride blisters, we developed a thermodiffusion setup that reproduces blister growth in reactor conditions. By metallography, nano-hardness, XRD and ERDA, we showed that they are constituted by 80% to 100% of δ hydrides in a Zircaloy-4 matrix, and that the zirconium beneath has some radially oriented hydrides. We modeled the blister growth kinetics taking into account the hysteresis of the hydrogen solubility limit and defined the thermal gradient threshold for blister growth. The modeling of the dilatometric behavior of hydrided zirconium indicates the important role of the material crystallographic texture, which could explain differences in the blister shape. Mechanical tests monitored with an infrared camera showed that significant local heating occurred at strain rates higher than 0.1/s. In parallel, the Expansion Due to Compression test was optimized to increase the bi-axiality level from uniaxial stress to plane strain (HB-EDC and VHB-EDC tests). This increase in loading bi-axiality lowers greatly the fracture strain at 25 C and 350 C only in homogeneous material without blister. Eventually, the ductility decrease of unirradiated Zircaloy-4 cladding tube in function of the blister depth was quantified. (author) [fr

  9. Low average blister-rust infection rates may mean high control costs

    Science.gov (United States)

    Robert Marty

    1965-01-01

    The Northeastern Forest Experiment Station, in cooperation with Federal and State forest-pest-control agencies, undertook a survey of blister-rust infection rates in the white pine region of the East during 1962 and 1963. Those engaged in blister-rust-control activities will not be surprised at the survey's results. We found that infection rates were significantly...

  10. Biology and pathology of Ribes and their implications for management of white pine blister rust

    Science.gov (United States)

    P. J. Zambino

    2010-01-01

    Ribes (currants and gooseberries) are telial hosts for the introduced and invasive white pine blister rust fungus, Cronartium ribicola. Knowledge of wild and introduced Ribes helps us understand the epidemiology of blister rust on its aecial hosts, white pines, and develop disease control and management strategies. Ribes differ by species in their contribution to...

  11. Blister rust in North America: What we have not learned in the past 100 years

    Science.gov (United States)

    Eugene P. Van Arsdel; Brian W. Geils

    2011-01-01

    Introduction of Cronartium ribicola (white pine blister rust) greatly motivated development of tree disease control and research in America. Although foresters and pathologists have learned much in the past 100 years, more remains to learn. The most important lesson is that fear of blister rust has reduced pine regeneration more than the disease itself. Based on six...

  12. Simulation Analysis of the Mutual Influence of the Stress Intensity Factor on the Multiple Blisters Caused by Hydrogen Induced Damage

    Science.gov (United States)

    Ji, Congwei; Zhang, Shaojie; Wang, Hehui

    2018-03-01

    Hydrogen blisters are taken as the research object by using the finite element software ABAQUS. The stress intensity factors of blister cracks are numerically calculated at varying depths and different edge distances for established three-dimensional finite element models of single-blister and double-blisters, respectively. The mutual influence of the stress intensity factors of the multiple blisters is obtained. It shows that the blister crack is easier to expand when the crack is closer to inner wall of the cylinder. What’s more, the crack growth rate increases firstly and then decreases as the increasing of the distance between two blisters cracks. The investigated result is of great reference value for predicting the trend of blister crack growth.

  13. Friction Blisters on the Hands Treated Successfully Using 2-Octyl Cyanoacrylate: A Case Report.

    Science.gov (United States)

    Gearhart, Peter A; Gaspar, Michael P; Jacoby, Sidney M

    Friction blisters on the hand are challenging to treat as conventional dressings are prone to saturation, contamination, and loosening with active hand use and other mechanical stresses. Alternative methods and materials for dressing hand blisters warrant exploration. A 48-year-old male surgeon presented with friction blisters over his bilateral thumbs. The patient complained of significant difficulty in keeping his dressings clean and dry, significant pain with hand hygiene, and functional limitations at work. The patient's blisters were dressed with 2-octyl cyanoacrylate (Dermabond; Ethicon US LLC, Somerville, New Jersey), applied directly onto the wound bed. The patient was able to perform his normal duties immediately, without the need for additional intervention. Six days postapplication, the Dermabond sloughed off, revealing an epithelialized surface. Dermabond is a promising agent for dressing unroofed blisters of the hand, as it provides a barrier to moisture and contamination, while allowing the wound to epithelialize, without functional cost.

  14. Temperature thresholds for surface blistering of platinum and stainless steel exposed to curium-242 alpha radiations

    International Nuclear Information System (INIS)

    McDonell, W.R.; Dillich, S.

    1981-01-01

    Implantation of helium in materials exposed to alpha-emitting radionuclides such as 242 Cm causes surface blistering at elevated temperatures. The temperature thresholds for such blistering are of practical importance to the selection of suitable container materials for radionuclides, and are of fundamental interest with regard to the mechanisms of helium blistering of materials in radiation environments. The purpose of this investigation was to establish temperature thresholds for surface blistering of platinum and stainless-steel container materials by post-irradiation heating of specimens exposed at room temperature to alpha particles from an external 242 Cm source. These thresholds were compared with (1) the analogous temperature thresholds for surface blistering of materials exposed to external beams of accelerator helium ions, and (2) thresholds for swelling and grain-boundary cracking of materials in which helium is generated internally by (n,α) reactions during reactor exposures

  15. Hydrogen blister formation on cold-worked tungsten with layered structure

    International Nuclear Information System (INIS)

    Nishijima, Dai; Sugimoto, Takanori; Takamura, Shuichi; Ye, Minyou; Ohno, Noriyasu

    2005-01-01

    Low-energy ( 10 21 m -2 s -1 ) hydrogen plasma exposures were performed on cold-worked powder metallurgy tungsten (PM-W), recrystallized cold-worked PM-W and hot-worked PM-W. Large blisters with a diameter of approximately 100-200 μm were observed only on the surface of cold-worked PM-W. The blister formation mechanism has not been clarified thus far. PM-W has a consisting of 1-μm-thick layers, which is formed by press-roll processing. A detailed observation of the cross section of those blisters shows for the first time that the blisters are formed by cleaving the upper layer along the stratified layer. These experimental results indicate that the manufacturing process of tungsten material is one of the key factors for blister formation on the tungsten surface. (author)

  16. Effect of solute elements in Ni alloys on blistering under He + and D + ion irradiation

    Science.gov (United States)

    Wakai, E.; Ezawa, T.; Takenaka, T.; Imamura, J.; Tanabe, T.; Oshima, R.

    2007-08-01

    Effects of solute atoms on microstructural evolution and blister formation have been investigated using Ni alloys under 25 keV He + and 20 keV D + irradiation at 500 °C to a dose of about 4 × 10 21 ions/m 2. The specimens used were pure Ni, Ni-Si, Ni-Co, Ni-Cu, Ni-Mn and Ni-Pd alloys. The volume size factors of solute elements for the Ni alloys range from -5.8% to +63.6%. The formations of blisters were observed in the helium-irradiated specimens, but not in the deuteron-irradiated specimens. The areal number densities of blisters increased with volume size difference of solute atoms. The dependence of volume size on the areal number densities of blisters was very similar to that of the number densities of bubbles on solute atoms. The size of the blisters inversely decreased with increasing size of solute atoms. The formation of blisters was intimately related to the bubble growth, and the gas pressure model for the formation of blisters was supported by this study.

  17. On the blister formation in copper alloys due to the helium ion implantation

    International Nuclear Information System (INIS)

    Moreno, D.; Eliezer, D.

    1997-01-01

    Structural materials in fusion reactors will be exposed to alpha radiation and helium implantation over a broad range of energies. A new approach to the blister-formation phenomenon is discussed by means of the mathematical solution on a uniformly loaded circular plate with clamped edges (circular diaphragm). In the present investigation, it was found that blister formation depends on the mechanical properties of the alloys and the near-surface concentration of the implanted gas, which itself is contingent on the crystallographic orientation by means of the stopping power of the implanted atoms. The reported model is based on the fact that at certain depths from the surface, the pressure in the cavities approaches the yield stress of the metal and blistering starts. The thickness of this thin film depends on the mechanical properties of the specific metal. Once a blister cavity is formed, the deformation of the thin film to form a blister cap depends on the buildup of pressure in the cavity contingent on the implanted dose. For the present model, it is sufficient to say that the thickness of the blister's cap cannot be correlated with the projected range of the implantation, as assumed by other authors. The implanted helium concentration needed to build up enough gas pressure to create a blister at a depth which is close to the projected range is higher by 50 times than the gas helium concentration in the cavity. Experimental results, such as the fact that the blisters have burst at the edge of the circular skin, where the maximum stresses are developed, and the fact that at high implantation energy (large projected range), the bursting of the blisters occurs by multilayer caps, support the present model

  18. Cantharidin biosynthesis in a blister beetle: inhibition by 6-fluoromevalonate causes chemical disarmament.

    Science.gov (United States)

    Carrel, J E; Doom, J P; McCormick, J P

    1986-07-15

    Biosynthesis of cantharidin in a blister beetle, Lytta polita, is effectively inhibited by 6-fluoromevalonate. Inhibition is attributed specifically to the fluorine substituent. Biochemical inhibition has not been demonstrated previously for an arthropod's defensive substance.

  19. Evaluation of hydride blisters in zirconium pressure tube in CANDU reactor

    International Nuclear Information System (INIS)

    Cheong, Y. M.; Kim, Y. S.; Gong, U. S.; Kwon, S. C.; Kim, S. S.; Choo, K.N.

    2000-09-01

    When the garter springs for maintaining the gap between the pressure tube and the calandria tube are displaced in the CANDU reactor, the sagging of pressure tube results in a contact to the calandria tube. This causes a temperature difference between the inner and outer surface of the pressure tube. The hydride can be formed at the cold spot of outer surface and the volume expansion by hydride dormation causes the blistering in the zirconium alloys. An incident of pressure tube rupture due to the hydride blisters had happened in the Canadian CANDU reactor. This report describes the theoretical development and models on the formation and growth of hydride blister and some experimental results. The evaluation methodology and non-destructive testing for hydride blister in operating reactors are also described

  20. Evaluation of hydride blisters in zirconium pressure tube in CANDU reactor

    Energy Technology Data Exchange (ETDEWEB)

    Cheong, Y M; Kim, Y S; Gong, U S; Kwon, S C; Kim, S S; Choo, K N

    2000-09-01

    When the garter springs for maintaining the gap between the pressure tube and the calandria tube are displaced in the CANDU reactor, the sagging of pressure tube results in a contact to the calandria tube. This causes a temperature difference between the inner and outer surface of the pressure tube. The hydride can be formed at the cold spot of outer surface and the volume expansion by hydride dormation causes the blistering in the zirconium alloys. An incident of pressure tube rupture due to the hydride blisters had happened in the Canadian CANDU reactor. This report describes the theoretical development and models on the formation and growth of hydride blister and some experimental results. The evaluation methodology and non-destructive testing for hydride blister in operating reactors are also described.

  1. Surface erosion of fusion reactor components due to radiation blistering and neutron sputtering

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminsky, M.

    1975-01-01

    Radiation blistering and neutron sputtering can lead to the surface erosion of fusion reactor components exposed to plasma radiations. Recent studies of methods to reduce the surface erosion caused by these processes are discussed

  2. The formation and characteristics of hydride blisters in c.w. Zircaloy-2 pressure tubes

    Energy Technology Data Exchange (ETDEWEB)

    Price, E G [ed.

    1994-09-01

    Under the auspices of the IAEA, a consultants` meeting was arranged in Vienna, 1994 July 25-29, at which a Canadian delegation, consisting of AECL and Ontario Hydro Technologies personnel, presented information on their knowledge of the behaviour of hydride blisters in Zircaloy-2 pressure tubes. This document contains the 10 papers presented by the Canadian delegation to the meeting. It is believed that they represent a good reference document on hydride blister phenomena.

  3. Whisker growth: a new mechanism for helium blistering of surfaces in complex radiation environments

    International Nuclear Information System (INIS)

    McDonell, W.R.

    1978-01-01

    Implantation of helium concurrent with the generation of large numbers of displaced atoms in surface layers of materials exposed to 252 Cf α-particles and fission fragments produces a unique form of low temperature surface blistering. The purpose of this paper is to formulate a basis for the whisker-growth mechanism for helium blistering as an aid to the specification of conditions under which the mechanism might apply

  4. The role of implanted gas and lateral stress in blister formation mechanisms

    International Nuclear Information System (INIS)

    Evans, J.H.

    1978-01-01

    In this paper the parts played by gas and lateral stress in blister formation on metal surfaces after helium implantation are critically reviewed. Although measurements show the existence of lateral stresses in implanted surfaces, an analysis indicates that these stresses can play little part in blister formation. Conversely, there is a strong case for a gas driven model. One possible mechanism, that involving the interbubble fracture of overpressurised helium bubbles, is outlined and revised to take recent measurements into account. (Auth.)

  5. Radiation blistering of niobium in sequence irradiated by helium ions with different energy

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminskij, M.S.; Guseva, M.I.; Gusev, V.M.; Krasulin, Yu.L.; Martynenko, Yu.V.; Rozina, I.A.

    1977-01-01

    The results of the investigation of the blistering of the surface of polycrystalline niobium foils subjected to successive irradiation by helium ions of energies of 3 to 50 keV are reported. The critical doses of irradiation, the types of blisters and the rate of erosion were determined. A comparative analysis of the formation of blisters on cold-rolled and annealed niobium has been made. On cold-rolled niobium the blistering is mainly due to ions with energies of 3 to 80 keV, on annealed niobium of 100 to 500 keV. The erosion of cold-rolled niobium takes place through blisters formed by the action of helium ions with energies of the order of 45 keV, and that of annealed niobium, through helium ions with energies of 100 to 500 keV. The observed differences in the formation of blisters on niobium irradiated with helium ions of a wide range of energies are explained by the change in the diffusion kinetics of implanted ions having a uniform distribution across the thickness of the target

  6. Obtention of the constitutive equation of hydride blisters in fuel cladding from nanoindentation tests

    Energy Technology Data Exchange (ETDEWEB)

    Martin Rengel, M.A., E-mail: mamartin.rengel@upm.es [E.T.S.I. Caminos, Canales y Puertos, Universidad Politécnica de Madrid, c/ Profesor Aranguren, 3, E-28040 Madrid (Spain); Gomez, F.J., E-mail: javier.gomez@amsimulation.com [Advanced Material Simulation, AMS, Bilbao (Spain); Rico, A., E-mail: alvaro.rico@urjc.es [DIMME, Universidad Rey Juan Carlos, Mostoles (Spain); Ruiz-Hervias, J. [E.T.S.I. Caminos, Canales y Puertos, Universidad Politécnica de Madrid, c/ Profesor Aranguren, 3, E-28040 Madrid (Spain); Rodriguez, J. [DIMME, Universidad Rey Juan Carlos, Mostoles (Spain)

    2017-04-15

    It is well known that the presence of hydrides in nuclear fuel cladding may reduce its mechanical and fracture properties. This situation may be worsened as a consequence of the formation of hydride blisters. These blisters are zones with an extremely high hydrogen concentration and they are usually associated to the oxide spalling which may occur at the outer surface of the cladding. In this work, a method which allows us to reproduce, in a reliable way, hydride blisters in the laboratory has been devised. Depth-sensing indentation tests with a spherical indenter were conducted on a hydride blister produced in the laboratory with the aim of measuring its mechanical behaviour. The plastic stress-strain curve of the hydride blister was calculated for first time by combining depth-sensing indentation tests results with an iterative algorithm using finite element simulations. The algorithm employed reduces, in each iteration, the differences between the numerical and the experimental results by modifying the stress-strain curve. In this way, an almost perfect adjustment of the experimental data was achieved after several iterations. The calculation of the constitutive equation of the blister from nanoindentation tests, may involve a lack of uniqueness. To evaluate it, a method based on the optimization of parameters of analytical equations has been proposed in this paper. An estimation of the error which involves this method is also provided.

  7. Synergistic helium and deuterium blistering in tungsten–tantalum composites

    Energy Technology Data Exchange (ETDEWEB)

    Dias, M., E-mail: marta.dias@itn.pt [Associação Euratom/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Mateus, R.; Catarino, N.; Franco, N. [Associação Euratom/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Nunes, D. [CENIMAT-I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa, 2829-516 Caparica (Portugal); Correia, J.B. [LNEG, Laboratório Nacional de Energia e Geologia, Estrada do Paço do Lumiar, 1649-038 Lisboa (Portugal); Carvalho, P.A. [Associação Euratom/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); ICEMS, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Hanada, K. [AIST, National Institute of Advanced Industrial Science and Technology, 1-2-1 Namiki, Tsukuba, 305-8564 Ibaraki (Japan); Sârbu, C. [National Institute of Materials and Physics, 105bis Atomistilor street, 077125 Magurele-Ilfov (Romania); and others

    2013-11-15

    Abstruct: Tungsten–tantalum composites with 10 and 20 at.% Ta were prepared by ball milling W powder with Ta fibers and by consolidating the milled materials with spark plasma sintering. The composites were implanted at room temperature with He{sup +} (30 keV with a fluence 5 × 10{sup 21} at/m{sup 2}) and/or D{sup +} (15 keV with a fluence 5 × 10{sup 21} at/m{sup 2}) ion beams. The materials were studied by scanning and high-resolution transmission electron microscopy, both coupled with energy dispersive X-ray spectroscopy, and by X-ray diffraction, Rutherford backscattering spectrometry and nuclear reaction analysis. The microstructure observations revealed that the milling operation resulted in severe fragmentation of the Ta fibers. Furthermore, during the consolidation process the Ta phase acted as oxygen getter and reduced the W oxide present in the original material. The surface of the tungsten–tantalum composites implanted with D{sup +} remained essentially unaltered, while the materials implanted with He{sup +} evidenced blisters on the Ta-rich regions. D retention in the composites increased with He{sup +} pre-implantation.

  8. Synergistic helium and deuterium blistering in tungsten–tantalum composites

    International Nuclear Information System (INIS)

    Dias, M.; Mateus, R.; Catarino, N.; Franco, N.; Nunes, D.; Correia, J.B.; Carvalho, P.A.; Hanada, K.; Sârbu, C.

    2013-01-01

    Abstruct: Tungsten–tantalum composites with 10 and 20 at.% Ta were prepared by ball milling W powder with Ta fibers and by consolidating the milled materials with spark plasma sintering. The composites were implanted at room temperature with He + (30 keV with a fluence 5 × 10 21 at/m 2 ) and/or D + (15 keV with a fluence 5 × 10 21 at/m 2 ) ion beams. The materials were studied by scanning and high-resolution transmission electron microscopy, both coupled with energy dispersive X-ray spectroscopy, and by X-ray diffraction, Rutherford backscattering spectrometry and nuclear reaction analysis. The microstructure observations revealed that the milling operation resulted in severe fragmentation of the Ta fibers. Furthermore, during the consolidation process the Ta phase acted as oxygen getter and reduced the W oxide present in the original material. The surface of the tungsten–tantalum composites implanted with D + remained essentially unaltered, while the materials implanted with He + evidenced blisters on the Ta-rich regions. D retention in the composites increased with He + pre-implantation

  9. Summary of the works on blistering and related erosion phenomena in JAERI

    International Nuclear Information System (INIS)

    Kamada, Kohji

    1980-01-01

    The works in JAERI on the blistering and related erosion phenomena on material surfaces have been made theoretically and experimentally. The theoretical studies were concerned with the blistering and flaking mechanisms from the standpoint of pressure driven model. A condition for blistering was introduced as a result of the theoretical work. Assuming ductile crack propagation in an ion-irradiated subsurface layer due to the presence of small spherical bubbles, blistering and flaking are reasonably discriminated on the basis of a single mechanism of gas driven model. Experimentally, the in-situ observations of blistered surfaces were carried out with a scanning electron microscope connected to a 2 MeV Van de Graaff accelerator. Targets were single crystals of Nb, Mo, Cu and Al. The flaking in pyrolytic graphite due to He + , Ne + , Ar + and N + ion bombardments, and the hole-formation in glassy carbon by Ne + ion bombardment were also studied. The theoretical explanation gave satisfactory agreements with the experimental results. The in-situ observation of blistering and subsequent exfoliation during 100 keV He + bombardment on a polycrystalline Mo surface was carried with a 400 keV Cockcroft-Walton type ion accelerator. It was found by scanning electron microscopy that the surface erosion due to blistering was effectively reduced by the multi-groove structure. The phenomena named grain ejection were found by bombardment with pulsed intense beam of 25 keV H + , as well as H 2 + , in the temperature range of 150 to 250 degree C. (Kato, T.)

  10. A gene network bioinformatics analysis for pemphigoid autoimmune blistering diseases.

    Science.gov (United States)

    Barone, Antonio; Toti, Paolo; Giuca, Maria Rita; Derchi, Giacomo; Covani, Ugo

    2015-07-01

    In this theoretical study, a text mining search and clustering analysis of data related to genes potentially involved in human pemphigoid autoimmune blistering diseases (PAIBD) was performed using web tools to create a gene/protein interaction network. The Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database was employed to identify a final set of PAIBD-involved genes and to calculate the overall significant interactions among genes: for each gene, the weighted number of links, or WNL, was registered and a clustering procedure was performed using the WNL analysis. Genes were ranked in class (leader, B, C, D and so on, up to orphans). An ontological analysis was performed for the set of 'leader' genes. Using the above-mentioned data network, 115 genes represented the final set; leader genes numbered 7 (intercellular adhesion molecule 1 (ICAM-1), interferon gamma (IFNG), interleukin (IL)-2, IL-4, IL-6, IL-8 and tumour necrosis factor (TNF)), class B genes were 13, whereas the orphans were 24. The ontological analysis attested that the molecular action was focused on extracellular space and cell surface, whereas the activation and regulation of the immunity system was widely involved. Despite the limited knowledge of the present pathologic phenomenon, attested by the presence of 24 genes revealing no protein-protein direct or indirect interactions, the network showed significant pathways gathered in several subgroups: cellular components, molecular functions, biological processes and the pathologic phenomenon obtained from the Kyoto Encyclopaedia of Genes and Genomes (KEGG) database. The molecular basis for PAIBD was summarised and expanded, which will perhaps give researchers promising directions for the identification of new therapeutic targets.

  11. Depth distribution of bubbles in 4He+-ion irradiated nickel and the mechanism of blister formation

    International Nuclear Information System (INIS)

    Fenske, G.; Das, S.K.; Kaminsky, M.; Miley, G.H.

    1978-01-01

    While the radiation blistering phenomenon has been widely studied, the mechanism of blister formation is still not well understood. The present studies on depth distribution of helium bubbles in nickel were carried out in order to obtain a better understanding of the radiation blistering process. Particularly, the aim was to understand the experimental observation that the blister skin thickness for many metals irradiated with He + ions of energies lower than 20-keV is a factor of two or more larger than the calculated projected range. (Auth.)

  12. An interbubble fracture mechanism of blister formation on helium-irradiated metals

    International Nuclear Information System (INIS)

    Evans, J.H.

    1977-01-01

    This paper describes a new model of surface blister formation in which a blister is nucleated by the interbubble fracture of highly overpressurized helium bubbles. As in other gas-driven models, the internal release of helium then provides the driving force for blister lid deformation. The high pressures required for the suggested mode of fracture are a result of the difficulty, experienced by the bubbles in acquiring vacancies. By considering the bubble growth mechanisms, the critical conditions for interbubble fracture are shown to depend on the helium dose and energy, the bubble size, and their depth in the irradiated material. These parameters and other aspects of blister formation are discussed on the basis of the proposed model. One important result concerns the position of the fracture plane; because of the usual displacement of damage and helium peaks relative to depth, this plane can lie well beyond the helium peak. Thus, the disagreement inherent in previous gas models between helium range and measured blister lid thickness values can be resolved without recourse to lateral stress arguments. (Auth.)

  13. Blistering and exfoliation of 304 stainless steel studied by SEM and RBS

    International Nuclear Information System (INIS)

    Braun, M.; Emmoth, B.; Whitton, J.L.

    1981-01-01

    Blistering and exfoliation induced by helium irradiation have been studied in polycrystalline stainless steel with the aim of measuring flake or blister skin thicknesses for different implantation energies in the keV region. The authors present measurements of skin thicknesses determined both by direct SEM observations and RBS techniques. The results of the RBS studies show for all implantation energies used that the thickness measured in target atoms/unit area of a flake equals the calculated implantation range with an accuracy of about 10%. Conversely, the SEM measurements show that swelling gives rise to a geometrical skin thickness much greater than the corresponding implantation range. Thus from the SEM and RBS data swelling as a function of the implantation energy is obtained and the linear relative swelling is shown to be strongly dependent on the energy. In addition a comparison between the skin thickness of blisters and flakes has been made for the same material. Blisters were observed at low implantation temperatures and room temperature while exfoliation occurs at elevated temperatures. The result of this comparison is that within the experimental accuracy the flake and blister thicknesses are the same. (Auth.)

  14. Reduction of surface erosion caused by helium blistering in sintered beryllium and sintered aluminum powder

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminsky, M.

    1976-01-01

    Studies have been conducted to find materials with microstructures which minimize the formation of blisters. A promising class of materials appears to be sintered metal powder with small average grain sizes and low atomic number Z. Studies of the surface erosion of sintered aluminum powder (SAP 895) and of aluminum held at 400 0 C due to blistering by 100 keV helium ions have been conducted and the results are compared to those obtained earlier for room temperature irradiation. A significant reduction of the erosion rate in SAP 895 in comparison to annealed aluminum and SAP 930 is observed. In addition results on the blistering of sintered beryllium powder (type I) irradiated at room temperature and 600 0 C by 100 keV helium ions are given. These results will be compared with those reported recently for vacuum cast beryllium foil and a foil of sintered beryllium powder (type II) which was fabricated differently, than type I. For room temperature irradiation only a few blisters could be observed in sintered beryllium powder type I and type II and they are smaller in size and in number than in vacuum cast beryllium. For irradiation at 600 0 C large scale exfoliation of blisters was observed for vacuum cast beryllium but much less exfoliation was seen for sintered beryllium powder, type I, and type II. The results show a reduction in erosion rate cast beryllium, for both room temperature and 600 0 C

  15. Internal Carotid Artery Blister-Like Aneurysm Caused by Aspergillus – Case Report

    International Nuclear Information System (INIS)

    Ogawa, Masaki; Sakurai, Keita; Kawaguchi, Takatsune; Naiki-Ito, Aya; Nakagawa, Motoo; Okita, Kenji; Matsukawa, Noriyuki; Shibamoto, Yuta

    2015-01-01

    Blister-like aneurysm of the supraclinoid internal carotid artery (ICA) is a well-documented cause of subarachnoid hemorrhage. Generally, this type of aneurysm is associated with various conditions such as hypertension, arteriosclerosis, and ICA dissection. Although Aspergillus is the most common organism causing intracranial fungal aneurysmal formation, there is no report of a blister-like aneurysm caused by Aspergillus infection. An 83-year-old man received corticosteroid pulse therapy followed by oral steroid therapy for an inflammatory pseudotumor of the clivus. Two months later, the patient was transported to an emergency department due to the diffuse subarachnoid hemorrhage, classified as Fisher group 4. Subsequent 3D computed tomography angiogram revealed a blister-like aneurysm at the superior wall of the left ICA. Six days later, the patient died of subarachnoid hemorrhage caused by the left ICA aneurysm rerupture. Autopsy revealed proliferation of Aspergillus hyphae in the wall of the aneurysm. Notably, that change was present more densely in the inner membrane than in the outer one. Thus, it was considered that Aspergillus hyphae caused infectious aneurysm formation in the left ICA via hematogenous seeding rather than direct invasion. The blister-like aneurysm is a rare but important cause of subarachnoid hemorrhage. This case report documents another cause of blister-like aneurysms, that is an infectious aneurysm associated with Aspergillus infection

  16. IMMUNOHISTOCHEMISTRY VERSUS IMMUNOFLUORESENCE IN THE DIAGNOSIS OF AUTOIMMUNE BLISTERING DISEASES

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2013-11-01

    Full Text Available Introduction: In patients with autoimmune skin blistering diseases (ABDs, the diagnostic gold standard has classically been direct and indirect immunofluorescence (DIF and IIF, despite inherent technical problems of autofluorescence. Aim: We sought to overcome autofluorescence issues and compare the reliability of immunofluorescence versus immunohistochemistry (IHC staining in the diagnoses of these diseases. Methods: We tested via IHC for anti-human IgG, IgM, IgA, IgD, IgE, Kappa light chains, Lambda light chains, Complement/C3c, Complement/C1q, Complement/C3d, albumin and fibrinogen in 30 patients affected by a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF, and 30 control biopsies from the endemic area. We also tested archival biopsies from patients with ABDs whose diagnoses were made clinically, histopathologically and by DIF/IIF studies from 2 independent dermatopathology laboratories in the USA. Specifically, we tested 34 patients with bullous pemphigoid (BP, 18 with pemphigus vulgaris (PV, 8 with pemphigus foliaceus (PF, 14 with dermatitis herpetiformis (DH and 30 control skin samples from plastic esthetic surgery reduction surgeries. Results: The diagnostic correlation between IHC and DIF-IIF was almost 98% in most cases. IHC revealed evidence of autofluorescence around dermal blood vessels, dermal eccrine glands and neurovascular packages feeding skin appendices in ABDs; this autofluorescence may represent a non-specific immune response. Strong patterns of positivity were seen also in endothelial-mesenchymal cell junction-like structures, as well as between dermal fibrohistiocytic cells. In PV, we noted strong reactivity to neurovascular packages supplying sebaceous glands, as well as apocrine glands with edematous changes. Conclusions: We suggest that IHC is as reliable as DIF or IIF for the diagnosis of ABDs; our findings further suggest that what has previously been considered DIF/IIF autofluorescence

  17. Coma blisters in children: case report and review of the literature.

    Science.gov (United States)

    Bosco, Laura; Schena, Donatella; Colato, Chiara; Biban, Paolo; Girolomoni, Giampiero

    2013-12-01

    Coma-induced blisters is a rare condition associated with prolonged impairment of conscious level, which is relatively well-known in adults following overdose with barbiturates. However, it has been very rarely described in children. A case of coma-bullae occurring in an 11-year-old child with meningoencephalitis is herein reported. The bullous lesions occurred on the limbs and trunks, and evolved into necrotic ulcers in a few days. No correlation with any drug overdosage was found. A skin biopsy revealed epidermal and eccrine sweat gland necrosis with abundant neutrophils, and thrombosis of the vessels in the lower dermis. A comprehensive review of the literature showed that only 5 cases of coma-bullae in children have been published so far. Coma blistering resolves spontaneously within days or weeks. Diagnosis of coma-bullae may require careful clinical-pathologic correlation to exclude other blistering diseases in children.

  18. Comparative morphological analysis of apple blister mite, Eriophyes mali Nal., a new pest in Serbia

    Directory of Open Access Journals (Sweden)

    Biljana Vidović

    2014-06-01

    Full Text Available The apple blister mite, Eriophyes mali Nalepa, 1926 (Acari: Prostigmata: Eriophyoidea, has been recently found in Serbia as a new pest of apple. The history of its research, the results of a morphological analysis and degree of infestation are presented. A comparison of the main morphological features of mites from different populations of remote geographical origin has shown that the apple blister mite from Serbia is most similar to another European population (Bulgarian [or Austrian?] while it differs from E. mali originating from the USA and New Zealand. The percentage of infestation varied from 1.6% to 87.6%, with an average of 22.4%.

  19. White pine blister rust in Korea, Japan and other Asian regions: comparisons and implications for North America

    Science.gov (United States)

    M.-S. Kim; N. B. Klopfenstein; Y. Ota; S. K. Lee; K.-S. Woo; S. Kaneko

    2010-01-01

    This article briefly reviews the history of white pine blister rust, attributed to Cronartium ribicola, and addresses current research and management issues in South Korea, Japan and other regions of eastern Asia (China, Russia and Himalaya). For each region, the distribution, damage, aecial hosts, telial hosts and management of C. ribicola and other blister rust fungi...

  20. White pine blister rust resistance of 12 western white pine families at three field sites in the Pacific Northwest

    Science.gov (United States)

    Richard A. Sniezko; Robert Danchok; Jim Hamlin; Angelia Kegley; Sally Long; James Mayo

    2012-01-01

    Western white pine (Pinus monticola Douglas ex D. Don) is highly susceptible to the non-native, invasive pathogen Cronartium ribicola, the causative agent of white pine blister rust. The susceptibility of western white pine to blister rust has limited its use in restoration and reforestation throughout much of western North...

  1. White pine blister rust in northern ldaho and western Montana: alternatives for integrated management

    Science.gov (United States)

    Susan K. Hagle; Geral I. McDonald; Eugene A. Norby

    1989-01-01

    This report comprises a handbook for managing western white pine in northern ldaho and western Montana, under the threat of white pine blister rust. Various sections cover the history of the disease and efforts to combat it, the ecology of the white pine and Ribes, alternate host of the rust, and techniques for evaluating the rust hazard and attenuating it. The authors...

  2. BLISTERING AND DEGRADATION OF POLYURETHANE COATINGS UNDER DIFFERENT ACCELERATED WEATHERING TESTS. (R828081E01)

    Science.gov (United States)

    An epoxy primer with a high gloss polyurethane topcoat coating system was exposed either only in a QUV chamber or exposed in a QUV chamber and a Prohesion chamber, alternatively, in this study. AFM studies found that micro blisters formed on the coating surface after both expo...

  3. Monitoring white pine blister rust infection and mortality in whitebark pine in the Greater Yellowstone ecosystem

    Science.gov (United States)

    Cathie Jean; Erin Shanahan; Rob Daley; Gregg DeNitto; Dan Reinhart; Chuck Schwartz

    2011-01-01

    There is a critical need for information on the status and trend of whitebark pine (Pinus albicaulis) in the Greater Yellowstone Ecosystem (GYE). Concerns over the combined effects of white pine blister rust (WPBR, Cronartium ribicola), mountain pine beetle (MPB, Dendroctonus ponderosae), and climate change prompted an interagency working group to design and implement...

  4. Conservation of biodiversity in sugar pine: effects of the blister rust epidemic on genetic diversity

    Science.gov (United States)

    Constance I. Millar; Bohun B. Kinloch; Robert D. Westfall

    1992-01-01

    Genetic diversity in sugar plne will be severely reduced by the blister rust pandemic predicted within the next 50 to 75 years. We model effects of the epidemic on genetic diversity at the stand and landscape levels for both natural and artificial regeneration. In natural stands, because natural frequencies of the dominant gene (R) for resistance are low, the most...

  5. Determining the feasibility of objective adherence measurement with blister packaging smart technology

    NARCIS (Netherlands)

    Onzenoort, H.A. van; Neef, C.; Verberk, W.W.; van Iperen, H.P.; Leeuw, P.W. de; van der Kuy, P.H.

    2012-01-01

    PURPOSE: The results of a feasibility study of blister-pack smart technology for monitoring medication adherence are reported. METHODS: Research in the area of objective therapy compliance measurement has led to the development of microprocessor-driven systems that record the time a unit dose is

  6. Blistering effects in neutral injection systems operated with helium and hydrogen gases: a preliminary assessment

    International Nuclear Information System (INIS)

    Hamilton, G.W.

    1977-01-01

    The practical effects of blistering and flaking in neutral injection systems are studied. These effects will soon be more important because of energy increases in systems now under development and because of their operation with fast helium ions as well as hydrogen and deuterium ions. Two main effects were studied: enhanced erosion rate and possible voltage breakdown from sharp flakes and gas emission

  7. Depth distribution of bubbles in He-ion irradiated nickel and the mechanism of blister formation

    International Nuclear Information System (INIS)

    Fenske, G.; Das, S.K.; Kaminsky, M.; Miley, G.H.

    1978-01-01

    Studies carried out to understand the experimental observation that the blister skin thickness for many metals irradiated with He + ions of energies lower than 20 keV is a factor of two or more larger than the calculated projected range are reported. Nickel foils were used with 20 and 500 keV helium ions

  8. Strong partial resistance to white pine blister rust in sugar pine

    Science.gov (United States)

    Bohun B. Kinloch, Jr.; Deems Burton; Dean A. Davis; Robert D. Westfall; Joan Dunlap; Detlev Vogler

    2012-01-01

    Quantitative resistance to white pine blister rust in 128 controlled- and open-pollinated sugar pine families was evaluated in a “disease garden”, where alternate host Ribes bushes were interplanted among test progenies. Overall infection was severe (88%), but with great variation among and within families: a 30-fold range in numbers of infections...

  9. Cyclosporin A levels in suction-blister fluid of patients with psoriasis treated systemically

    NARCIS (Netherlands)

    Meinardi, M. M.; van Eendenburg, J. P.; Oosting, J.; van Boxtel, C. J.; de Rie, M. A.; Bos, J. D.

    1990-01-01

    Oral cyclosporin A (CyA) is highly effective in the treatment of psoriasis. The long-term use is limited by dose-dependent side-effects, and the local concentration of CyA is a determining factor in treatment. The concentration of CyA in suction-blister fluid (SBF) and in whole blood was assessed

  10. Selection for resistance to white pine blister rust affects the abiotic stress tolerances of limber pine

    Science.gov (United States)

    Patrick J. Vogan; Anna W. Schoettle

    2015-01-01

    Limber pine (Pinus flexilis) mortality is increasing across the West as a result of the combined stresses of white pine blister rust (Cronartium ribicola; WPBR), mountain pine beetle (Dendroctonus ponderosae), and dwarf mistletoe (Arceuthobium cyanocarpum) in a changing climate. With the continued spread of WPBR, extensive mortality will continue with strong selection...

  11. Antibiotics Do Not Control Blister Rust in Eastern White Pine Seedlings

    Science.gov (United States)

    William R. Phelps; Ray Weber

    1968-01-01

    To prevent blister rust infections in Eastern white pine seedlings, the antibiotics, cycloheximide (acti-dione) and Phytoactin, were tested in root dips, root slurries, and foliar drenches before planting and after planting the trees. None of the methods and materials tested was effective.

  12. White pine blister rust resistance in limber pine: Evidence for a major gene

    Science.gov (United States)

    A. W. Schoettle; R. A. Sniezko; A. Kegley; K. S. Burns

    2014-01-01

    Limber pine (Pinus flexilis) is being threatened by the lethal disease white pine blister rust caused by the non-native pathogen Cronartium ribicola. The types and frequencies of genetic resistance to the rust will likely determine the potential success of restoration or proactive measures. These first extensive inoculation trials using individual tree seed collections...

  13. Resistance to white pine blister rust in Pinus flexilis and P

    Science.gov (United States)

    Anna W. Schoettle; Richard A. Sniezko; Angelia Kegley; Jerry Hill; Kelly S. Burns

    2010-01-01

    The non-native fungus Cronartium ribicola, that causes white pine blister rust (WPBR), is impacting or threatening limber pine, Pinus flexilis, and Rocky Mountain bristlecone pine, Pinus aristata. In the Southern Rockies, where the rust invasion is still expanding, we have the opportunity to be proactive and prepare the landscape for invasion. Genetic...

  14. Preempting the pathogen: Blister rust and proactive management of high-elevation pines

    Science.gov (United States)

    Sue Miller; Anna Schoettle; Kelly Burns; Richard Sniezko; Patty Champ

    2017-01-01

    White pine blister rust has been spreading through western forests since 1910, causing widespread mortality in a group that includes some of the oldest and highest-elevation pines in the United States. The disease has recently reached Colorado and is expected to travel through the southern Rockies. Although it cannot be contained, RMRS researchers and collaborators are...

  15. Hydrogen-induced blistering of Mo/Si multilayers: Uptake and distribution

    NARCIS (Netherlands)

    Kuznetsov, Alexey; Gleeson, M.A.; Bijkerk, Frederik

    2013-01-01

    We report on the uptake of deuterium by thin-film Mo/Si multilayer samples as a result of exposure to fluxes of predominantly thermal atomic and molecular species, but also containing a small fraction of energetic (800–1000 eV) ions. These exposures result in blister formation characterized by layer

  16. Hydrogen-induced blistering of Mo/Si multilayers: Uptake and distribution

    NARCIS (Netherlands)

    Kuznetsov, A. S.; Gleeson, M. A.; F. Bijkerk,

    2013-01-01

    Abstract We report on the uptake of deuterium by thin-film Mo/Si multilayer samples as a result of exposure to fluxes of predominantly thermal atomic and molecular species, but also containing a small fraction of energetic (800 1000 eV) ions. These exposures result in blister formation

  17. Limber pine forests on the leading edge of white pine blister rust distribution in Northern Colorado

    Science.gov (United States)

    Jennifer G. Klutsch; Betsy A. Goodrich; Anna W. Schoettle

    2011-01-01

    The combined threats of the current mountain pine beetle (Dendroctonus ponderosae, MPB) epidemic with the imminent invasion of white pine blister rust (caused by the non-native fungus Cronartium ribicola, WPBR) in limber pine (Pinus flexilis) forests in northern Colorado threatens the limber pine's regeneration cycle and ecosystem function. Over one million...

  18. Histology of white pine blister rust in needles of resistant and susceptible eastern white pine

    Science.gov (United States)

    Joel A. Jurgens; Robert A. Blanchette; Paul J. Zambino; Andrew David

    2003-01-01

    White pine blister rust, Cronartium ribicola, has plagued the forests of North America for almost a century. Over past decades, eastern white pine (Pinus strobus) that appear to tolerate the disease have been selected and incorporated into breeding programs. Seeds from P. strobus with putative resistance were...

  19. Increased Activity and Apoptosis of Eosinophils in Blister Fluids, Skin and Peripheral Blood of Patients with Bullous Pemphigoid.

    Science.gov (United States)

    Engmann, Judith; Rüdrich, Urda; Behrens, Georg; Papakonstantinou, Eleni; Gehring, Manuela; Kapp, Alexander; Raap, Ulrike

    2017-04-06

    Bullous pemphigoid (BP) is an autoimmune blistering skin disease that is more common in elderly individuals. The aim of this study was to determine the functional activity of eosinophils in patients with BP compared with healthy donors. Blood, skin and blister-derived eosinophils were strongly activated in patients with BP, seen by increased surface expression of CD69 compared with controls. CD11b was also increased in BP blood eosinophils, which may explain the striking accumulation of eosinophils in BP (1×106 per ml blister fluid). Furthermore, CCL26 was expressed by activated eosinophils in BP skin and in blister fluid. BP eosinophils also released IL-6, IL-8 and IL-1α in BP blister fluids. Apoptosis in cultivated BP eosinophils was increased and accompanied by enhanced surface externalization of CD95. Caspase 3 positive eosinophils in lesional BP skin and blister fluid also showed the initiation of apoptosis. These results reveal novel pathophysiological aspects of BP, with a strong activation pattern and increased apoptosis of eosinophils in the peripheral blood, skin and blister fluids.

  20. Investigation of blister formation in sputtered Cu{sub 2}ZnSnS{sub 4} absorbers for thin film solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Bras, Patrice, E-mail: patrice.bras@angstrom.uu.se [Midsummer AB, Elektronikhöjden 6, SE-17543 Järfälla, Sweden and Solid State Electronics, Angström Laboratory, Uppsala University, Box 534, SE-75121 Uppsala (Sweden); Sterner, Jan [Midsummer AB, Elektronikhöjden 6, SE-17543 Järfälla (Sweden); Platzer-Björkman, Charlotte [Solid State Electronics, Angström Laboratory, Uppsala University, Box 534, SE-75121 Uppsala (Sweden)

    2015-11-15

    Blister formation in Cu{sub 2}ZnSnS{sub 4} (CZTS) thin films sputtered from a quaternary compound target is investigated. While the thin film structure, composition, and substrate material are not correlated to the blister formation, a strong link between sputtering gas entrapment, in this case argon, and blistering effect is found. It is shown that argon is trapped in the film during sputtering and migrates to locally form blisters during the high temperature annealing. Blister formation in CZTS absorbers is detrimental for thin film solar cell fabrication causing partial peeling of the absorber layer and potential shunt paths in the complete device. Reduced sputtering gas entrapment, and blister formation, is seen for higher sputtering pressure, higher substrate temperature, and change of sputtering gas to larger atoms. This is all in accordance with previous publications on blister formation caused by sputtering gas entrapment in other materials.

  1. Whitebark pine mortality related to white pine blister rust, mountain pine beetle outbreak, and water availability

    Science.gov (United States)

    Shanahan, Erin; Irvine, Kathryn M.; Thoma, David P.; Wilmoth, Siri K.; Ray, Andrew; Legg, Kristin; Shovic, Henry

    2016-01-01

    Whitebark pine (Pinus albicaulis) forests in the western United States have been adversely affected by an exotic pathogen (Cronartium ribicola, causal agent of white pine blister rust), insect outbreaks (Dendroctonus ponderosae, mountain pine beetle), and drought. We monitored individual trees from 2004 to 2013 and characterized stand-level biophysical conditions through a mountain pine beetle epidemic in the Greater Yellowstone Ecosystem. Specifically, we investigated associations between tree-level variables (duration and location of white pine blister rust infection, presence of mountain pine beetle, tree size, and potential interactions) with observations of individual whitebark pine tree mortality. Climate summaries indicated that cumulative growing degree days in years 2006–2008 likely contributed to a regionwide outbreak of mountain pine beetle prior to the observed peak in whitebark mortality in 2009. We show that larger whitebark pine trees were preferentially attacked and killed by mountain pine beetle and resulted in a regionwide shift to smaller size class trees. In addition, we found evidence that smaller size class trees with white pine blister rust infection experienced higher mortality than larger trees. This latter finding suggests that in the coming decades white pine blister rust may become the most probable cause of whitebark pine mortality. Our findings offered no evidence of an interactive effect of mountain pine beetle and white pine blister rust infection on whitebark pine mortality in the Greater Yellowstone Ecosystem. Interestingly, the probability of mortality was lower for larger trees attacked by mountain pine beetle in stands with higher evapotranspiration. Because evapotranspiration varies with climate and topoedaphic conditions across the region, we discuss the potential to use this improved understanding of biophysical influences on mortality to identify microrefugia that might contribute to successful whitebark pine conservation

  2. Reproduction in Laboratory and characterization of Blister of Hydride of zirconium in nuclear fuel pods; Reproduccion en laboratorio y caracterizacion de Blisters de hidroduro de circonio en muestras de vaina de combustible nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Martin Rengel, M. A.; Ruiz-Hervias, J.; Munoz, P.

    2014-07-01

    This paper have replicated in laboratory blisters of different size in samples of pod of ZIRLO pre-hydrided evenly with 500 ppm of hydrogen. For these samples was used a technique of cathodic charging in basic medium. To produce the blister was heated up to about 350 degree centigrade in its outer surface sample. With the aim of producing a point cold on the surface of the sheath contacted the surface with a piece of aluminum water-cooled (cold finger). Was held a morphological characterization of the blisters by means of optical microscopy and found that the size of the produced blister is function of the contact time between fuel pod and cold finger. (Author)

  3. The effect of alpha incident- and poloidal-angle distributions on blister-induced first-wall erosion

    International Nuclear Information System (INIS)

    Fenske, G.; Hively, L.; Miley, G.

    1979-01-01

    The incident velocity distribution of high-energy alpha particles bombarding the first wall of an axisymmetric tokamak is evaluated as a function of poloidal angle (theta). The resulting helium concentration profile as a function of the poloidal angle and the implant depth is calculated for a typical Experimental Power Reactor (EPR) design. The critical helium concentration for blistering is first exceeded at theta approx. 55 0 . Peak concentrations are reduced somewhat through continuous D-T sputtering which, dependent on theta, reduces the blister skin thicknesses. The blistering-induced impurity level is found to increase drastically (< approx. 50%), relative to sputtering-induced impurities, at periodic intervals corresponding to approx. 4000 hours operation when each generation of blister begins to exfoliate. (orig.)

  4. Blister formation and hydrogen retention in aluminium and beryllium: A modeling and experimental approach

    Directory of Open Access Journals (Sweden)

    C. Quirós

    2017-08-01

    Full Text Available Experiments were performed in a low pressure-high density plasma reactor in order to study the impact of hydrogen retention in aluminium under plasma conditions. Microscopy scans of the surface were performed before and after 1h plasma exposure (fluence 6.1 ×1023ions/m2 where it is seen that blisters start to nucleate at the grain boundaries. Investigation on blister growth kinetics was performed for fluences ranging between 6 ×1023 and 3.7 ×1024ions/m2. The evolution of the characteristic size of the projected area was also analyzed. Finally, a macroscopic rate equations (MRE code was used to simulate hydrogen retention and diffusion in Al and bubble growth in the bulk was simulated using experimental results. This model was also used to simulate these phenomena in Be and compare its behavior with respect to Al.

  5. Effect of periodic deuterium ion irradiation on deuterium retention and blistering in Tungsten

    Directory of Open Access Journals (Sweden)

    M. Oya

    2017-08-01

    Full Text Available The effect of periodic irradiation on Deuterium (D retention and blistering in Tungsten (W was investigated. W samples were exposed to D plasma at a fixed fluence while varying the irradiation cycle number (1-shot, 2-shots and 3-shots. Exposure energy and flux were ∼50eV and ∼1 ×1022 D m−2 s−1, respectively. Sample temperatures were 537K and 643K. At 573K, D retention and blister density decreased with increasing number of irradiation cycle. In contrast at 643K, D retention showed no dependence on number of irradiation cycle. Therefore, sample temperature during irradiation is an important parameter in comparing the results of continuous and periodic irradiation, especially in studies involving extremely-high-flux (>1024 D m−2 s−1 irradiation and fluence dependency of D retention.

  6. Boat Hull Blisters: Repair Techniques and Long Term Effects on Hull Degradation

    Science.gov (United States)

    1988-08-01

    X 12’ waxed glass mold. Orthophthalic Acid/ Neopentyl glycol based gel coat was used in the R, RA, RA and RD series. Isophthalic acid/keopentyl glycol ...a boat manufacturer. The gel coat was isophthalic acid and / neopentyl glycol based. The laminating resin used was isophthalic acid/propylene glycol ...something present in the resin itself. We have reported blistering vhen sorbitol is added to the resin. Pritchard has reported on the role of excess glycol

  7. The use of suction blisters to measure sunscreen protection against UVR-induced DNA damage.

    Science.gov (United States)

    Josse, Gwendal; Douki, Thierry; Le Digabel, Jimmy; Gravier, Eleonore; Questel, Emmanuel

    2018-02-01

    The formation of DNA photoproducts caused by solar UVR exposure needs to be investigated in-vivo and in particular in order to assess sunscreens' level of protection against solar genotoxicity. The study's purposes were: i) to evaluate if the roof of suction blisters is an appropriate sampling method for measuring photoproducts, and ii) to measure in-vivo sunscreen protection against cyclobutane pyrimidine dimers. Skin areas on the interior forearms of eight healthy volunteers were exposed in-vivo to 2 MED of simulated solar radiation (SSR) and to 15 MED on a sunscreen protected area. After irradiation, six suction blisters were induced and the blister roofs were collected. Analysis of SSR-induced CPDs was performed by two independent methods: a chromatography coupled to mass spectroscopy (HPLC-MS/MS) approach and a 3D-imaging of CPD immunostaining by multiphoton microscopy on floating epidermal sheets. HPLC-MS/MS analyses showed that SSR-unexposed skin presented no CPD dimers, whereas 2 MED SSR-exposed skin showed a significant number of TT-CPD. The sunscreen covered skin exposed to 15 MED appeared highly protected from DNA damage, as the amount of CPD-dimers remained below the detection limit. The multiphoton-immunostaining analysis consistently showed that no CPD staining was observed on the non-SSR-exposed skin. A significant increase of CPD staining intensity and number of CPD-positive cells were observed on the 2 MED SSR-exposed skin. Sunscreen protected skin presented a very low staining intensity and the number of CPD-positive cells remained very close to non-SSR-exposed skin. This study showed that suction blister samples are very appropriate for measuring CPD dimers in-vivo, and that sunscreens provide high protection against UVR-induced DNA damage. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Observations of suppressed retention and blistering for tungsten exposed to deuterium-helium mixture plasmas

    International Nuclear Information System (INIS)

    Miyamoto, M.; Morito, S.; Ono, K.; Nishijima, D.; Doerner, R.P.; Baldwin, M.J.; Hanna, J.; Ueda, Y.; Kurishita, H.

    2009-01-01

    Blister formation and D retention in W have been investigated for low energy (∼55 ± 15 eV), high flux (∼10 22 m -2 s -1 ), high fluence (≤4.5 x 10 26 m -2 ) ion bombardment at moderate temperature (∼573 K) in mixed species D+He plasmas in the linear divertor plasma simulator PISCES-A. The amount of D retained in W is found to decrease significantly when compared with that in W exposed to pure D plasmas, as measured with high resolution thermal desorption spectroscopy. Scanning electron microscopy observations reveal the suppression of the blisters, a surface feature known to drive up retention, in the D + He mixture plasma exposed W samples. Reduced D retention is accompanied by the formation of nano-sized high density He bubbles in the near surface, observed with a transmission electron microscope (TEM). It is believed that the nano-bubbles act as a diffusion barrier to implanted D atoms and consequently reduce the amount of uptake in the W material. This newly observed effect implies that current predictions of D retention in W, in actual fusion devices, may be overestimated, since there will be He ash in fusion plasma. Toughness enhanced, fine-grained (grain size of ∼1 μm) W-TiC samples, exposed to pure D plasma conditions, also show little or no evidence of blistering. The measured D retention in the W-TiC samples was approximately 1 x 10 19 D m -2 corresponding to about 2 x 10 -7 of the implanted D fluence, and is very low compared with the retention in pure stress relieved W, which exhibited surface blisters and had a D retention of about 1 x 10 21 D m -2 .

  9. First report of the white pine blister rust pathogen, Cronartium ribicola, in Arizona

    Science.gov (United States)

    M. L. Fairweather; Brian Geils

    2011-01-01

    White pine blister rust, caused by Cronartium ribicola J.C. Fisch., was found on southwestern white pine (Pinus flexilis James var. reflexa Engelm., synonym P. strobiformis Engelm.) near Hawley Lake, Arizona (Apache County, White Mountains, 34.024°N, 109.776°W, elevation 2,357 m) in April 2009. Although white pines in the Southwest (Arizona and New Mexico) have been...

  10. Fine element (F.E.) modelling of hydrogen migration and blister formation in PHWR coolant channels

    International Nuclear Information System (INIS)

    Prasad, P.S.; Dutta, B.K.; Sinha, R.K.; Kushwaha, H.S.; Mahajan, S.C.; Kakodkar, A.

    1995-01-01

    The formation of a cold spot in pressure tube due to its contact with calandria tube of PHWR coolant results in the migration of Hydrogen in pressure tube towards contact zone from its surrounding material. A 3-D finite element code SPARSH is developed to model the hydrogen redistribution and consequent hydride blister formation due to thermal and Hydrogen concentration gradients. In the present paper, the details and performance of this code are presented. (author). 6 refs., 2 figs

  11. Evidence for a role of eosinophils in blister formation in bullous pemphigoid.

    Science.gov (United States)

    de Graauw, E; Sitaru, C; Horn, M; Borradori, L; Yousefi, S; Simon, H-U; Simon, D

    2017-07-01

    Bullous pemphigoid (BP) is an autoimmune bullous disease of the skin characterized by subepidermal blister formation due to tissue-bound and circulating autoantibodies to the hemidesmosomal antigens BP180 and BP230. Although eosinophils and their toxic mediators are found abundantly in BP lesions, their role in blister formation has remained unclear. To investigate the role of eosinophils in the pathogenesis of BP with a specific focus on blister formation and to define conditions inducing dermal-epidermal separation (DES). In an ex vivo human model of BP, normal human skin cryosections were incubated with purified human peripheral blood eosinophils with or without activation in the presence or absence of BP autoantibodies, brefeldin A, diphenyleneiodonium, DNase or blocking F(ab') 2 fragments to CD16, CD18, CD32 and CD64. Dermal-epidermal separation was assessed by light microscopy studies and quantified using Fiji software. Following activation with IL-5 and in the presence of BP autoantibodies, eosinophils induced separation along the dermal-epidermal junction of ex vivo skin. Dermal-epidermal separation was significantly reduced by blocking any of the following: Fcγ receptor binding (P = 0.048), eosinophil adhesion (P = 0.046), reactive oxygen species (ROS) production (P = 0.002), degranulation (P eosinophil extracellular trap (EET) formation (P = 0.048). Our results provide evidence that IL-5-activated eosinophils directly contribute to BP blister formation in the presence of BP autoantibodies. Dermal-epidermal separation by IL-5-activated eosinophils depends on adhesion and Fcγ receptor activation, requires elevated ROS production and degranulation and involves EET formation. Thus, targeting eosinophils may be a promising therapeutic approach for BP. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy.

    Science.gov (United States)

    Cohen, Philip R

    2016-04-18

     Bullous impetigo results from Staphylococcus aureus (S. aureus) release of exfoliative toxins type A and type B thatresults in flaccid, easily ruptured, bullae in the upper layers of the epidermis.  Physiologic, gestation-associated, and incidental skin changes can occur in pregnancy.  Blisters in pregnant women can occur secondary to either common skin disorders orspecific dermatoses of pregnancy.  To describe a pregnant woman with bullous impetigo and review bullous conditions in pregnant women.  PubMed was used to search the following terms, separately and in combination:  blister, blistering, bullous, gestationis, herpes, herpetiformis, impetigo, pemphigoid, pregnancy, pregnant, psoriasis, pustular, virus. All papers were reviewed and relevant manuscripts, along with their reference citations, were evaluated.  Flaccid, easily rupturing, pustules, which developed into superficial annular erosions with peripheral scale and central healing appeared in a woman of 7-weeks gestation and allergy to penicillin on her lower abdomen, suprapubic region, perineum, buttocks, and proximal legs.  A bacterial culture subsequently isolated methicillin-susceptible S. aureus.  All of the lesions resolved after treatment with clindamycin.  Bullous impetigo should be considered in the differential diagnosis of common skin diseases presenting as blistersin pregnant women.

  13. Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins

    Directory of Open Access Journals (Sweden)

    Donna Brennan

    2010-01-01

    Full Text Available Cell-cell adhesion mediated by desmosomes is crucial for maintaining proper epidermal structure and function, as evidenced by several severe and potentially fatal skin disorders involving impairment of desmosomal proteins. Pemphigus foliaceus (PF and staphylococcal scalded skin syndrome (SSSS are subcorneal blistering diseases resulting from loss of function of the desmosomal cadherin, desmoglein 1 (Dsg1. To further study the pathomechanism of these diseases and to assess the adhesive properties of Dsg2, we employed a recently established transgenic (Tg mouse model expressing Dsg2 in the superficial epidermis. Neonatal Tg and wild type (WT mice were injected with purified ETA or PF Ig. We showed that ectopic expression of Dsg2 reduced the extent of blister formation in response to both ETA and PF Ig. In response to PF Ig, we observed either a dramatic loss or a reorganization of Dsg1-α, Dsg1-β, and, to a lesser extent, Dsg1-γ, in WT mice. The Inv-Dsg2 Tg mice showed enhanced retention of Dsg1 at the cell-cell border. Collectively, our data support the role for Dsg2 in cell adhesion and suggest that ectopic superficial expression of Dsg2 can increase membrane preservation of Dsg1 and limit epidermal blister formation mediated by PF antibodies and exfoliative toxins.

  14. Investigation of the Cause of Low Blister Threshold Temperatures in the RERTR-12 and AFIP-4 Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell K Meyer

    2012-06-01

    Blister–threshold testing of fuel plates is a standard method through which the safety margin for operation of plate-type in research and test reactors is assessed. The blister-threshold temperature is indicative of the ability of fuel to operate at high temperatures for short periods of time (transient conditions) without failure. This method of testing was applied to the newly developed U-Mo monolithic fuel system. Blister annealing studies on the U-Mo monolithic fuel plates began in 2007, with the Reduced Enrichment for Research and Test Reactors (RERTR)-6 experiment, and they have continued as the U-Mo fuel system has evolved through the research and development process. Blister anneal threshold temperatures from early irradiation experiments (RERTR-6 through RERTR-10) ranged from 400 to 500°C. These temperatures were projected to be acceptable for NRC-licensed research reactors and the high-power Advanced Test Reactor (ATR) and the High Flux Isotope Reactor (HFIR) based on current safety-analysis reports (SARs). Initial blister testing results from the RERTR-12 experiment capsules X1 and X2 showed a decrease in the blister-threshold temperatures. Blister threshold temperatures from this experiment ranged from 300 to 400°C. Selected plates from the AFIP-4 experiment, which was fabricated using a process similar to that used to fabricate the RERTR-12 experiment, also underwent blister testing to determine whether results would be similar. The measured blister-threshold temperatures from the AFIP-4 plates fell within the same blister-threshold temperature range measured in the RERTR-12 plates. Investigation of the cause of this decrease in bister threshold temperature is being conducted under the guidance of Idaho National Laboratory PLN-4155, “Analysis of Low Blister Threshold Temperatures in the RERTR-12 and AFIP-4 Experiments,” and is driven by hypotheses. The main focus of the investigation is in the following areas: 1. Fabrication variables 2. Pre

  15. Blistering in a porous surface layer of materials. [He ion implantation

    Energy Technology Data Exchange (ETDEWEB)

    Afrikanov, I.N.; Vladimirov, B.G.; Guseva, M.I.; Ivanov, S.M.; Martynenko, Yu.V.; Nikol' skij, Yu.V.; Ryazanov, A.I.

    1981-03-01

    The effect of porous structure on the nature and rate of radiation erosion during implantation of helium ions into nickel and the OKh15N15M3B stainless steel is studied. The investigation results showed sharp dependence of the erosion rate due to blistering on the dimension and density of pores in the by-surface layer. The rate of the surface erosion increased in one order as compared with the control specimens without pores at 1% swelling for stainless steel and 4% for nickel.

  16. The influence of microstructure on blistering and bubble formation by He ion irradiation in Al alloys

    International Nuclear Information System (INIS)

    Soria, S.R.; Tolley, A.; Sánchez, E.A.

    2015-01-01

    The influence of microstructure and composition on the effects of ion irradiation in Al alloys was studied combining Atomic Force Microscopy, Scanning Electron Microscopy and Transmission Electron Microscopy. For this purpose, irradiation experiments with 20 keV He + ions at room temperature were carried out in Al, an Al–4Cu (wt%) supersaturated solid solution, and an Al-5.6Cu-0.5Si-0.5Ge (wt.%) alloy with a very high density of precipitates, and the results were compared. In Al and Al–4Cu, He bubbles were found with an average size in between 1 nm and 2 nm that was independent of fluence. The critical fluence for bubble formation was higher in Al–4Cu than in Al. He bubbles were also observed below the critical fluence after post irradiation annealing in Al–4Cu. The incoherent interfaces between the equilibrium θ phase and the Al matrix were found to be favorable sites for the formation of He bubbles. Instead, no bubbles were observed in the precipitate rich Al-5.6Cu-0.5Si-0.5Ge alloy. In all alloys, blistering was observed, leading to surface erosion by exfoliation. The blistering effects were more severe in the Al-5.6Cu-0.5Si-0.5Ge alloy, and they were enhanced by increasing the fluence rate. - Highlights: • In Al and Al–4Cu, He bubbles were formed, but no bubbles were observed in Al-5.6Cu-0.5Si-0.5Ge. • Bubble formation was enhanced at incoherent matrix/precipitate interfaces in Al–4Cu. • The bubble size was insensitive to displacement rate in pure Al. • In Al and Al-5.6Cu-0.5Si-0.5Ge blistering was observed, which was more severe in the alloy. • Blistering effects were enhanced by increasing the displacement rate in Al and Al–4Cu.

  17. Pill in the blister pack: a rare cause of dysphagia in an elderly adult

    Science.gov (United States)

    Laeeq, Syed Mudassir; Rai, Ayesha Aslam; Tasneem, Abbas Ali; Luck, Nasir Hassan; Majid, Zain

    2015-01-01

    Foreign body impaction in the esophagus amongst adults is not a common cause of dysphagia. Fish bone, food bolus, dentures may cause symptoms of dysphagia, odynophagia, chest pain or respiratory distress. It needs prompt evaluation along with removal of the substance either surgically or endoscopically to avoid the development of life threatening complications. Here we are reporting a case of an elderly male, who presented to us with a history of absolute dysphagia for one week, as a consequence of ingestion of a pill in blister pack. PMID:26918072

  18. The surface blistering kinetics and the H-platelet evolution in H-implanted germanium

    International Nuclear Information System (INIS)

    Yang Fan; Zhang Xuanxiong; Ye Tianchun; Zhuang Songlin

    2012-01-01

    The surface blistering phenomenon produced in H-implanted Ge by a series of low temperature annealing processes was investigated. The kinetic plot of the onset of blistering contains a break point that separates the straight-line plot into two parts, with two distinct slopes based on the calculated activation energy from the different temperature regions for 3×10 16 cm -2 and 5×10 16 cm -2 H-implanted doses. This plot indicates the existence of distinct, temperature dependent mechanisms, probably caused by the release of different types of H-platelets. The turning direction (from low to high temperature) of the Arrhenius plot with the break point is contrary to that of other known materials. The formation and evolution of the H-platelets under the Ge surface was revealed by TEM (transmission electron microscopy). The TEM results demonstrate that the 〈0 0 1〉 platelets parallel to the sample surface are first produced by a low H implantation dose; however, the vertical 〈0 1 0〉 platelets perpendicular to the sample surface form later as the H implantation dose increases. The H-platelets combine with each other, becoming micro-cracks. The {1 1 1} and {3 1 1} micro-cracks serve as interconnections between the 〈0 0 1〉-oriented micro-cracks below the substrate surface. Finally, the accumulated H 2 pressure in the cracks deforms the surface to generate Ge surface exfoliation.

  19. Blister rust resistance among 19 families of whitebark pine, Pinus albicaulis, from Oregon and Washington – early results from an artificial inoculation trial

    Science.gov (United States)

    Angelia Kegley; Richard A. Sniezko; Robert Danchok; Douglas P. Savin

    2012-01-01

    Whitebark pine is considered one of the most susceptible white pine species to white pine blister rust, the disease caused by the non-native pathogen Cronartium ribicola. High mortality from blister rust and other factors in much of the range in the United States and Canada have raised serious concerns about the future viability of this high-...

  20. Blister/hole formation on tungsten surface due to low-energy and high-flux deuterium/helium plasma exposures

    International Nuclear Information System (INIS)

    Nishijima, D.; Iwakiri, H.; Yoshida, N.; Ye, M.Y.; Ohno, N.; Takamura, S.

    2005-01-01

    Deuterium/helium plasma exposures on tungsten surface bring serious damages such as blister and hole. Blistering occurs by cleaving along layered structure intrinsic to the press-roll manufacturing process. Mechanical polishing and helium pre-exposure on mirror-finished powder metallurgy tungsten drastically suppress blister formation. Small cracks made by a polishing would become paths to the surface for diffusing deuterium atoms in the substrate, resulting in no gas accumulation and no blister formation on the surface. Helium pre-exposure would make a helium-enriched layer near the surface, which becomes a kind of diffusion barrier for incident deuterium atoms. Blister formation and deuterium retention are suppressed on the surface with helium-enriched layer. (author)

  1. Characterization of the effect generated by the preformed and formed processes applied to drainage catheters of Quadrathane"T"M, in the blistered defect

    International Nuclear Information System (INIS)

    Rodriguez Forero, Diana Catalina

    2014-01-01

    The effect generated by preformed and formed processes on drainage catheters is characterized in the blistered defect. The potential root causes generated from the blistered defect are identified by the experimental design of one factor at a time. The experimental phases performed on the blistered defect have been: chemical interaction, humidity, mechanical stress, parameters RO Bonding, parameters of temperature and time of retention in the forming process. The application of quality control process methodology is recommended to obtain robust information about the defect and the process in general. Polymeric extrusions and construction of drainage catheters processes are described. The processes of preformed, formed and blistered defect are explained. The incidence of blistered defect and the yields of each batch produced of catheters should be controlled by means of weekly records to avoid further complications at the level of yield or quality [es

  2. Blistering in ALD Al2O3 passivation layers as rear contacting for local Al BSF Si solar cells

    NARCIS (Netherlands)

    Vermang, B.; Goverde, J.C.; Uruena, A.; Lorenz, A.; Cornagliotti, E.; Rothschild, A.; John, J.; Poortmans, J.; Mertens, R.

    2012-01-01

    Random Al back surface field (BSF) p-type Si solar cells are presented, where a stack of Al2O3 and SiNx is used as rear surface passivation layer containing blisters. It is shown that no additional contact opening step is needed, since during co-firing local Al BSFs are induced at the location of

  3. Non-Ribes alternate hosts of white pine blister rust: What this discovery means to whitebark pine

    Science.gov (United States)

    Paul J. Zambino; Bryce A. Richardson; Geral I. McDonald; Ned B. Klopfenstein; Mee-Sook. Kim

    2006-01-01

    From early to present-day outbreaks, white pine blister rust caused by the fungus Cronartium ribicola, in combination with mountain pine beetle outbreaks and fire exclusion has caused ecosystem-wide effects for all five-needled pines (McDonald and Hoff 2001). To be successful, efforts to restore whitebark pine will require sound management decisions that incorporate an...

  4. 4.4.5S: Genetic interactions of white pines and blister rust in western North America

    Science.gov (United States)

    Bohun B. Kinloch Jr.

    1998-01-01

    A century since its introduction to North America from Europe, white pine blister rust has come to be recognized as one of the catastrophic plant disease epidemics in history. It has yet to stabilize, continuing to spread and intensify. The nine native white pine hosts comprise major timber producers, important watershed protectors, keystone ecological species, and the...

  5. Chitosan-induced immunity in Camellia sinensis (L.) O. Kuntze against blister blight disease is mediated by nitric-oxide.

    Science.gov (United States)

    Chandra, Swarnendu; Chakraborty, Nilanjan; Panda, Koustubh; Acharya, Krishnendu

    2017-06-01

    Blister blight disease, caused by an obligate biotrophic fungal pathogen, Exobasidium vexans Massee is posing a serious threat for tea cultivation in Asia. As the use of chemical pesticides on tea leaves substantially increases the toxic risks of tea consumption, serious attempts are being made to control such pathogens by boosting the intrinsic natural defense responses against invading pathogens in tea plants. In this study, the nature and durability of resistance offered by chitosan and the possible mechanism of chitosan-induced defense induction in Camellia sinensis (L.) O. Kuntze plants against blister blight disease were investigated. Foliar application of 0.01% chitosan solution at 15 days interval not only reduced the blister blight incidence for two seasons, but also maintained the induced expressions of different defense related enzymes and total phenol content compared to the control. Defense responses induced by chitosan were found to be down regulated under nitric oxide (NO) deficient conditions in vivo, indicating that the observed chitosan-induced resistance is probably activated via NO signaling. Such role of NO in host defense response was further established by application of the NO donor, sodium nitroprusside (SNP), which produced similar defense responses accomplished through chitosan treatment. Taken together, our results suggest that increased production of NO in chitosan-treated tea plants may play a critical role in triggering the innate defense responses effective against plant pathogens, including that causing the blister blight disease. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  6. Size determinations, by ultrasonic techniques, of cracks in hydride blisters formed in Zr-2.5 % Nb pressure tubes

    International Nuclear Information System (INIS)

    Trujillo Badillo, Giovanna; Desimone, Carlos; Domizzi, Gladys

    1999-01-01

    Non destructive techniques (NDT) are very useful in the detection of flaws produced in structural components in service. During the service of CANDU nuclear power reactors, it is possible that pressure tubes (PT) may contact calandria tubes (CT). After the PT/CT contact, zirconium hydride blisters may form at the point of contact depending on the concentration of hydrogen/deuterium. Zirconium hydride is brittle and is therefore prone to cracking under stress. Ultrasonic NDT is routinely use during PT in service inspection. In order to be able of detecting cracked blisters, it is of great importance the development of standards to calibrate the employed equipment. On this purpose, hydride blisters were grown, in laboratory, on sections of pressure tube. The cracks in the blisters were detected and measured by ultrasonic techniques. The obtained results were compared with measurements carried out in optic microscope, on successive sections of the samples. The crack tip diffraction technique was found to be the more effective for the mentioned ends. (author)

  7. Status of white pine blister rust and seed collections in california's high-elevation white pine species

    Science.gov (United States)

    J. Dunlap

    2011-01-01

    White pine blister rust (caused by the non-native pathogen Cronartium ribicola) reached northern California about 80 years ago. Over the years its spread southward had been primarily recorded on sugar pine. However, observations on its occurrence had also been reported in several of the higher elevation five-needled white pine species in California. Since the late...

  8. Activated charcoal and baking soda to reduce odor associated with extensive blistering disorders.

    Science.gov (United States)

    Chakravarthi, Arun; Srinivas, C R; Mathew, Anil C

    2008-01-01

    Skin disease leading to extensive blistering and loss of skin is associated with a characteristic smell. Odor can cause physiologic disturbances such as increase in heart rate and respiratory rate. It can also cause nausea and vomiting and is disturbing to bystanders. To test odor reducing capability of activated charcoal. In this blinded experimental study we used putrefied amniotic membrane to produce odor and studied the effectiveness of activated charcoal and soda-bi-carbonate to reduce odor. Statistical analysis with Kruskal Wall's Chi Square Test and Man Whitney U test showed significant reduction of odor using activated charcoal by itself or along with soda-bi-carbonate. We recommend the usage of activated charcoal with/without soda bicarbonate as an inexpensive practical measure to reduce foul odor associated with extensive skin loss.

  9. Activated charcoal and baking soda to reduce odor associated with extensive blistering disorders

    Directory of Open Access Journals (Sweden)

    Chakravarthi Arun

    2008-01-01

    Full Text Available Background: Skin disease leading to extensive blistering and loss of skin is associated with a characteristic smell. Odor can cause physiologic disturbances such as increase in heart rate and respiratory rate. It can also cause nausea and vomiting and is disturbing to bystanders. Aims: To test odor reducing capability of activated charcoal. Methods: In this blinded experimental study we used putrefied amniotic membrane to produce odor and studied the effectiveness of activated charcoal and soda-bi-carbonate to reduce odor. Results: Statistical analysis with Kruskal Wall′s Chi Square Test and Man Whitney U test showed significant reduction of odor using activated charcoal by itself or along with soda-bi-carbonate. Conclusion: We recommend the usage of activated charcoal with/without soda bicarbonate as an inexpensive practical measure to reduce foul odor associated with extensive skin loss.

  10. White blister rusts and downy mildews from bajaur agency fata, with some new records from pakistan

    International Nuclear Information System (INIS)

    Haq, M.A.; Shahzad, S.

    2015-01-01

    In a species diversity study of Oomycyctes of Bajaur Agency FATA, Pakistan, infection of white blister rusts and downy mildews recorded on three cultivated and four wild plants. Capsella bursa-pastoris showed mixed infection of Albugo candida and Hyaloperonospora parasitica (syn: Peronospora parasitica). Similarly, A. candida and H. brassicae (syn: P. brassicae) parasitized Brassica campestris. Wilsoniana portulacae (syn: Albugo portulacae) and W. occidentalis com. nov. (syn: Albugo occidentalis) recovered from Portulaca oleracea and Spinacia oleracea, respectively. Bremia taraxaci, B. sonchicola and B. saussureae recorded on Taraxicum officinale, Sonchus sp., and Saussurea sp., respectively. All these obligate parasites are new records from Bajaur Agency, while H. parasitica, W. occidentalis, B. taraxaci, and B. saussureae on the mentioned hosts are new records from Pakistan. (author)

  11. Genetic transformation with the gfp gene of Colletotrichum gloeosporioides isolates from coffee with blister spot

    Directory of Open Access Journals (Sweden)

    Cecilia Armesto

    2012-09-01

    Full Text Available Blister spot (Colletotrichum gloeosporioides is now widespread in most coffee producing states of Brazil, becoming a limiting factor for production. The lack of data relating to the reproduction of typical symptoms (light green, oily patches leaves a gap within the pathosystem, forcing the search for new methodologies for monitoring the disease. Monitoring of genetically modified organisms has proven to be an effective tool in understanding the host x pathogen interactions. Thus, the present study was carried out to evaluate the effectiveness of two systems of genetic transformation in obtaining mutants using the gfp reporter gene. Using the two transformation systems (PEG and electroporation revealed the efficiency of both, confirmed by fluorescence microscopy and resistance to the antibiotic hygromycin-B, when incorporated into the culture medium. The fungus maintained its cultural and morphological characteristics when compared to wild strains. When inoculated on coffee seedlings, it was found that the pathogenicity of the processed isolates had not changed.

  12. Complete genome sequence of a proposed new tymovirus, tomato blistering mosaic virus.

    Science.gov (United States)

    Nicolini, Cícero; Inoue-Nagata, Alice Kazuko; Nagata, Tatsuya

    2015-02-01

    In a previous work, a distinct tymovirus infecting tomato plants in Brazil was reported and tentatively named tomato blistering mosaic virus (ToBMV). In this study, the complete genome sequence of ToBMV was determined and shown to have a size of 6277 nucleotides and three ORFs: ORF 1 encodes the replication-complex polyprotein, ORF 2 the movement protein, and ORF 3 the coat protein. The cleavage sites of the replication-complex polyprotein (GS/LP and VAG/QSP) of ToBMV were predicted by alignment analysis of amino acid sequences of other tymoviruses. In the phylogenetic tree, ToBMV clustered with the tymoviruses that infect solanaceous hosts.

  13. Deuterium implantation into Y{sub 2}O{sub 3}-doped and pure tungsten: Deuterium retention and blistering behavior

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, M. [School of Materials Science and Engineering, University of Science and Technology, Beijing, Beijing 100083 (China); Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, Garching 85748 (Germany); Jacob, W., E-mail: wolfgang.jacob@ipp.mpg.de [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, Garching 85748 (Germany); Manhard, A.; Gao, L.; Balden, M.; Toussaint, U. von [Max-Planck-Institut für Plasmaphysik, Boltzmannstr. 2, Garching 85748 (Germany); Zhou, Z. [School of Materials Science and Engineering, University of Science and Technology, Beijing, Beijing 100083 (China)

    2017-04-15

    The blistering and near-surface deuterium retention of a Y{sub 2}O{sub 3}-doped tungsten (W) and two different pure W grades were studied after exposure to deuterium (D) plasma at elevated temperatures (370, 450 and 570 K). Samples were exposed to a deuterium fluence of 6 × 10{sup 24} D m{sup −2} applying a moderate ion flux of about 9 × 10{sup 19} D m{sup −2} s{sup −1} at an ion energy of 38 eV/D. Morphological modifications at the surface were analyzed by confocal laser scanning microscopy and scanning electron microscopy. The D depth profiles and the accumulated D inventories within the topmost 8 μm were determined by nuclear reaction analysis. Blistering and deuterium retention were strongly dependent on the implantation temperature. In addition, blistering was sensitively influenced by the used tungsten grade, although the total amount of retained D measured by nuclear reaction analysis was comparable. Among the three different investigated tungsten grades, Y{sub 2}O{sub 3}-doped W exhibited the lowest degree of surface modification despite a comparable total D retention. - Highlights: •Y{sub 2}O{sub 3}-doped W and 2 pure W were exposed to D plasma at 370, 450 and 570 K. •D retention in all 3 materials is comparable. •D plasma exposure leads to blister formation on all investigated W grades. •Blister morphology and size distribution depend strongly on W grade. •Y{sub 2}O{sub 3}-doped W shows the lowest degree of surface modification.

  14. Relationship between theoretical molecular weight and blister fluid/serum ratio of cytokines and five other molecules evaluated in patients with bullous pemphigoid.

    Science.gov (United States)

    D'Auria, L; Pimpinelli, F; Ferraro, C; D'Ambrogio, G; Giacalone, B; Bellocci, M; Ameglio, F

    1998-01-01

    Bullous pemphigoid (BP) blisters contain several molecules, some of which spread into the blisters from the interstitial fluid, while others are produced locally and migrate into the circulation. The calculation of the ratios between blister/serum concentrations may help to distinguish between these two types of molecules. The rules regulating the diffusion of the molecules have been described only in suction blisters, where the theoretical molecular weight (MW) represents one of the principal influencing factors. The aim of the present study was to analyse the relationship between theoretical MWs and the ratios of concentrations of several molecules evaluated both in sera and in blister fluids. Eight cytokines (interleukin-2, interleukin-3, interleukin-4, interleukin-5, interleukin-10, tumor necrosis factor-alpha, oncostatin-M and vascular endothelial growth factor), two acute phase reactants (alpha-1 acid glycoprotein, haptoglobin), albumin, one soluble membrane molecule with adhesion functions (sICAM-1) and the eosinophil cathionic protein (ECP) were measured in samples from 15 patients affected with BP by means of commercially available tests. The data suggest that the MW may influence the rate of diffusion throughout the blister, both in input and output directions, despite the discontinuity observed at the basement membrane level on the BP blister floor.

  15. Effect of preliminary neutron irradiation on helium blistering of 0Kh16N15M3B steel

    International Nuclear Information System (INIS)

    Chernov, I.I.; Kalin, B.A.; Skorov, D.M.; Shishkin, G.N.; Ivanov, M.V.

    1982-01-01

    The method of electron microscopy has been applied to investigate the effect of preliminary neutron irradiation on the OKh16N15M3B steel blistering under irradiation by 20 keV helium ions with (1-10)x10 21 ion/m 2 doses at the temperature below 373 K. It is shown that neutron irradiation shifts critical doses of blister formation and intense scaling towards higher doses. But after the incubation period the erosion of steel preliminary neutron irradiated grows with the increase of helium ion dose above 7x10 21 ion/m 2 . Short-term heating of neutron irradiated samples during 15 min at 1173 K does not practically affect the beginning of intense scaling of the surface

  16. Nanorobotic investigation identifies novel visual, structural and functional correlates of autoimmune pathology in a blistering skin disease model.

    Directory of Open Access Journals (Sweden)

    Kristina Seiffert-Sinha

    Full Text Available There remain major gaps in our knowledge regarding the detailed mechanisms by which autoantibodies mediate damage at the tissue level. We have undertaken novel strategies at the interface of engineering and clinical medicine to integrate nanoscale visual and structural data using nanorobotic atomic force microscopy with cell functional analyses to reveal previously unattainable details of autoimmune processes in real-time. Pemphigus vulgaris is a life-threatening autoimmune blistering skin condition in which there is disruption of desmosomal cell-cell adhesion structures that are associated with the presence of antibodies directed against specific epithelial proteins including Desmoglein (Dsg 3. We demonstrate that pathogenic (blister-forming anti-Dsg3 antibodies, distinct from non-pathogenic (non-blister forming anti-Dsg3 antibodies, alter the structural and functional properties of keratinocytes in two sequential steps--an initial loss of cell adhesion and a later induction of apoptosis-related signaling pathways, but not full apoptotic cell death. We propose a "2-Hit" model for autoimmune disruption associated with skin-specific pathogenic autoantibodies. These data provide unprecedented details of autoimmune processes at the tissue level and offer a novel conceptual framework for understanding the action of self-reactive antibodies.

  17. A novel blister test to evaluate the interface strength between nickel coating and low carbon steel substrate

    International Nuclear Information System (INIS)

    Xiao, L.H.; Su, Xu Ping.; Wang, J.H.; Zhou, Y.C.

    2009-01-01

    A novel blister test theory model was developed based on the bending theory of beams for assessing the interface strength of the nickel coating/low carbon steel substrate material system. The strain energy of the debonded nickel coating was calculated analytically and by finite element analysis, respectively. The analytic solutions agree well with the FE calculation results. Some blister tests were carried out on the WII-5 Computer Controlled Material Mechanical Properties Testing Machine, using four nickel-coated specimens type-A, -B, -C and -D which were electrodeposited on low carbon steel substrate. Here, types A, B, C and D correspond to the nickel coating thickness of 5 μm, 10 μm, 15μm and 25μm, respectively. The interface strength, evaluated by this blister test method, is 196.86 J/m 2 and 269.40 J/m 2 for type-C and -D specimens, respectively. However the tests demonstrate that the type-A and -B specimens were cut through by the spindle and no delaminations between the coating and the substrate could be found

  18. Transcriptome Analysis Reveals Candidate Genes involved in Blister Blight defense in Tea (Camellia sinensis (L) Kuntze)

    Science.gov (United States)

    Jayaswall, Kuldip; Mahajan, Pallavi; Singh, Gagandeep; Parmar, Rajni; Seth, Romit; Raina, Aparnashree; Swarnkar, Mohit Kumar; Singh, Anil Kumar; Shankar, Ravi; Sharma, Ram Kumar

    2016-07-01

    To unravel the molecular mechanism of defense against blister blight (BB) disease caused by an obligate biotrophic fungus, Exobasidium vexans, transcriptome of BB interaction with resistance and susceptible tea genotypes was analysed through RNA-seq using Illumina GAIIx at four different stages during ~20-day disease cycle. Approximately 69 million high quality reads were assembled de novo, yielding 37,790 unique transcripts with more than 55% being functionally annotated. Differentially expressed, 149 defense related transcripts/genes, namely defense related enzymes, resistance genes, multidrug resistant transporters, transcription factors, retrotransposons, metacaspases and chaperons were observed in RG, suggesting their role in defending against BB. Being present in the major hub, putative master regulators among these candidates were identified from predetermined protein-protein interaction network of Arabidopsis thaliana. Further, confirmation of abundant expression of well-known RPM1, RPS2 and RPP13 in quantitative Real Time PCR indicates salicylic acid and jasmonic acid, possibly induce synthesis of antimicrobial compounds, required to overcome the virulence of E. vexans. Compendiously, the current study provides a comprehensive gene expression and insights into the molecular mechanism of tea defense against BB to serve as a resource for unravelling the possible regulatory mechanism of immunity against various biotic stresses in tea and other crops.

  19. Degradation of the blister agent sulfur mustard, bis(2-chloroethyl) sulfide, on concrete

    International Nuclear Information System (INIS)

    Brevett, Carol A.S.; Sumpter, Kenneth B.; Wagner, George W.; Rice, Jeffrey S.

    2007-01-01

    The products formed from the degradation of the blister agent sulfur mustard [bis(2-chloroethyl) sulfide] on concrete were identified using gas chromatography with mass spectrometry detection (GC/MSD), 1 H NMR, 2D 1 H- 13 C NMR and 13 C solid state magic angle spinning (SSMAS) NMR. In situ and extraction experiments were performed. Sulfur mustard was detected in the in situ 13 C SSMAS samples for 12 weeks, whereas less than 5% of the sulfur mustard was detected in extracts from the concrete monoliths after 8 days. Sulfonium ions and (2-chloroethylthio)ethyl ether (T) were observed on the in situ samples after a period of 12 weeks, whereas vinyl species and bis(2-chloroethyl) sulfoxide were observed in the extracts of the concrete monoliths within 24 h. The differences between the extraction and the SSMAS data indicated that the sulfur mustard existed in the concrete in a non-extractable form prior to its degradation. Extraction methods alone were not sufficient to identify the products; methods to identify the presence of non-extractable degradation products were also required

  20. Fatigue and creep to leak tests of proton exchange membranes using pressure-loaded blisters

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yongqiang; Dillard, David A.; Case, Scott W. [Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0219 (United States); Ellis, Michael W. [Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0238 (United States); Lai, Yeh-Hung; Gittleman, Craig S.; Miller, Daniel P. [Fuel Cell Research Lab, GM R and D, General Motors Corporation, 10 Carriage Street, Honeoye Falls, NY 14472-0603 (United States)

    2009-12-01

    In this study, three commercially available proton exchange membranes (PEMs) are biaxially tested using pressure-loaded blisters to characterize their resistance to gas leakage under either static (creep) or cyclic fatigue loading. The pressurizing medium, air, is directly used for leak detection. These tests are believed to be more relevant to fuel cell applications than quasi-static uniaxial tensile-to-rupture tests because of the use of biaxial cyclic and sustained loading and the use of gas leakage as the failure criterion. They also have advantages over relative humidity cycling test, in which a bare PEM or catalyst coated membrane is clamped with gas diffusion media and flow field plates and subjected to cyclic changes in relative humidity, because of the flexibility in allowing controlled mechanical loading and accelerated testing. Nafion {sup registered} NRE-211 membranes are tested at three different temperatures and the time-temperature superposition principle is used to construct stress-lifetime master curve. Tested at 90 C, 2%RH extruded Ion Power {sup registered} N111-IP membranes have a longer lifetime than Gore trademark -Select {sup registered} 57 and Nafion {sup registered} NRE-211 membranes. (author)

  1. Acute fish liver intoxication induced blisters formation and generalized skin peeling.

    Science.gov (United States)

    Chang, Chih-Hao; Lu, Chun-Wei; Chung, Wen-Hung; Ho, Hsin-Chun

    2018-02-01

    Acute fish liver intoxication, including hypervitaminosis A and hypervitaminosis D, may result from the ingestion of certain fish livers. The typical symptoms of hypervitaminosis A include nausea, headache, blurred vision, and cutaneous manifestations, such as flushing, vesicles formation, and desquamation. Hypervitaminosis D may result in hypercalcemia. We report a case of acute fish liver intoxication with systemic and cutaneous manifestations. A 63-year-old male presented to the clinic with generalized desquamation and multiple clear-fluid filled flaccid vesicles after eating approximately two fist-sized portions (about 300-400 g) of cooked seerfish (Scomberomorus spp.) liver. Laboratory examination showed a high serum level of vitamin A and D, and hypercalcemia. Fish liver consumption from particular fish may result in acute hypervitaminosis A and D. In patients with skin detachment or blister formation, headache, drowsiness, and other symptoms and signs consistent with hypervitaminosis A and/or hypercalcemia, a history of fish intake should be sought, and a serum level of vitamin A and D should be measured.

  2. Blood blister-like aneurysms: Single center experience and systematic literature review

    International Nuclear Information System (INIS)

    Gonzalez, Ana Marcos; Narata, Ana Paula; Yilmaz, Hasan; Bijlenga, Philippe; Radovanovic, Ivan; Schaller, Karl; Lovblad, Karl-Olof; Pereira, Vitor Mendes

    2014-01-01

    Blood blister-like aneurysms (BBAs) are a controversial entity. They arise from non-branching sites on the supraclinoid internal carotid artery (ICA) and are suspected to originate from a dissection. Our aim is to describe the BBA cases seen in our center and to present a systematic review of the literature on BBAs. We analyzed the eleven cases of BBA admitted to our center from 2003 to 2012. We assessed the medical history, treatment modality (endovascular and/or surgery), complications and clinical outcome. The cohort included 8 women and 4 men with a mean age of 53.16 years. Treatment of the BBA consisted of stenting and coiling in 5 patients, stenting only in 4 patients, coiling and clipping in 1 patient, clipping only in 1 patient, and conservative treatment in 1 patient. A good outcome was found in 10 patients, as defined by a modified Rankin Scale (mRS) less than or equal to two at three months. A systematic review of the literature was performed, and 314 reported patients were found: 221 patients were treated with a primarily surgical approach, and 87 patients were treated with a primarily endovascular approach. A rescue or second treatment was required in 46 patients (21%). The overall estimated treatment morbidity rate was 17%, and the mortality rate was 15%. BBAs exhibit more aggressive behavior compared to saccular aneurysms, and more intra-operative complications occur with BBAs, independent of the treatment type offered. They are also significantly more likely to relapse and rebleed after treatment. Endovascular treatment offers a lower morbidity–mortality compared with surgical approaches. Multilayer flow-diverting stents appear to be a promising strategy

  3. Experimental study of changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in patients with vitiligo in progressive stage

    International Nuclear Information System (INIS)

    Bi Mingye; Huang Haifen

    2011-01-01

    Objective: To explore the significance of changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in patients with vitiligo in progressive stage. Methods: 80 patients with vitiligo in progressive stage were divided into two groups (vulgaris vitiligo groups : n=54, segmental vitiligo groups : n=26) Their blister fluid levels of NPY and GM-CSF were determined by radioimmunoassay(RIA), and IL-12 and sICAM-1 were determined by enzyme immunoassay. Results: The levels of skin blister fluid NPY were definitely higher in vitiliginous skin than those in non-vitiliginous patches in segmental vitiligo groups (P 0.05). The levels of skin blister fluid IL-12, sICAM-1 and GM-CSF were all obviously higher in vitiliginous skin than that in non-vitiliginous patches in vulgaris vitiligo groups (P 0.05). Conclusion: The changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in vitiliginous skin may be closely related to development of difference type vitiligo patients with vitiligo, determination of 4 indexes might be helpful for studying the pathogenesis and clinical diagnosis of vitiligo. (authors)

  4. Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes

    DEFF Research Database (Denmark)

    Khandelia, Himanshu; Duelund, Lars; Pakkanen, Kirsi Inkeri

    2010-01-01

    triolein molecules to the bilayer center in the form of a disordered, isotropic, mobile neutral lipid aggregate, at least 17 nm in diameter, which forms spontaneously, and remains stable on at least the microsecond time scale. The results give credence to the hotly debated existence of mobile neutral lipid...... aggregates of unknown function present in malignant cells, and to the early biogenesis of lipid droplets accommodated between the two leaflets of the endoplasmic reticulum membrane. The TO aggregates give the bilayer a blister-like appearance, and will hinder the formation of multi-lamellar phases in model...

  5. The viability of PVC/Al blister reuse and PVC property studies after ionizing radiation processing

    International Nuclear Information System (INIS)

    Castro, Alex Terela Pinheiro de

    2008-01-01

    The objective of this research was to separate, by means of a process of dissolution, the PVC and the aluminum that compose blister packs, generally used for pharmaceutical pills. We also studied the effect of the ionizing radiation on the PVC, and, finally, the mechanical recycling of the separated PVC, by a process of extrusion. The material we used in this work is the surplus of the pharmaceutical industry, i.e., packs with defects or burrs. We ground the material to facilitate the handling and the homogenization of the system. After that, we chose two bases for the dissolution of the aluminum: the sodium hydroxide and the potassium hydroxide. We used a system with two concentrations (1 and 2M) for each base, and for every solution we had also an agitated and a non-agitated process. From this method resulted eight experiments. After the dissolution, the samples of the material were submitted to ionizing radiation with doses of 50, 100, 150 and 200 kGy in the Dynamitron II electron accelerator of the CTR-IPEN/CNEN-SP. In the following, these samples were submitted to traction resistance tests to analyze which modifications the irradiation caused. The last step of the research was the recycling of the PVC separated from the Aluminum. We made the recycling in industrial equipment, a PVC tube extruder. The material was combined with lubricants, heat stabilizers and pigment in an intensive mixer and processed into the form of rigid PVC electrical conduits. After the eight experiments, the system with potassium hydroxide base, concentration of 2M and agitation presented the best relation between time of dissolution and characteristics of the resulting material, without degradation of the PVC. In the irradiated samples, the color of the material changed as well as its extension that was as larger as the dose of irradiation they received, indicating the dissociation of the PVC molecules. The extrusion of the PVC was successfully realized: about 200 kg (440 pounds) of

  6. Introduction of chemical, physical and mechanical coupling in the study of the blistering phenomena for semi-crystalline polymers; Une approche multiphysique de l'endommagement de polymeres en milieu petrolier: exemple du blistering

    Energy Technology Data Exchange (ETDEWEB)

    Cangemi, L.; Klopffer, M.H.; Martin, J. [Institut Francais du Petrole (IFP), 92 - Rueil-Malmaison (France); Grandidier, J.C. [Poitiers Univ., Lab. de Mecanique et de Physique des Materiaux, UMR 6617 CNRS, ENSMA, 86 (France)

    2005-09-01

    Polymer materials are used in numerous oil applications where the knowledge and the control of their barrier properties are required: thermosetting coatings, rubber seals, thermoplastic liners. In that case, thermoplastic materials are in contact with water, hydrocarbons, gases and all carried fluids at high temperature and high pressure (up to 13 deg C and to 100 MPa). Under these extreme conditions, gases contained in petroleum products (such as H{sub 2}S, CO{sub 2}) have a high tendency to dissolve into semi-crystalline polymers (polyolefins, fluorinated polymers). A decompression, i.e. a rupture of the thermodynamic equilibrium may eventually lead to gas concentration and temperature gradients in the polymer structures. The resulting damaging phenomenon is called blistering and can be really dramatic for the material because it is irreversible and may end the pipe leak-proofness. As a matter of fact, the condition of damage is mainly correlated to the temperature, the rate of decompression and the properties of the material. Thereby, it is important to have an accurate knowledge of all the involved phenomena in order to quantify and then predict the barrier properties of the materials in those aggressive conditions. The aim of this study is to identify the various mechanism involved in the blistering phenomena for semi-crystalline polymers (such as PVF2, PE), to establish some relations between the polymer microstructure (morphology), its mechanical properties and the damage and to build physicochemical models which will take into account some mechanical, thermal and diffusional aspects. (authors)

  7. Skin blister formation together with patterned intradermal hematoma: a special type of tire mark injury in victims run over by a wheel.

    Science.gov (United States)

    Pircher, R; Epting, T; Schmidt, U; Geisenberger, D; Pollak, S; Kramer, L

    2015-04-01

    A traffic accident victim run over by a vehicle may show a patterned skin hematoma reflecting the grooves of the tire's profile. Apart from this well-known type of imprint mark, the affected skin can also be blistered provided that the wheel exerts high pressure on the body for a prolonged period of time. The macro- and micromorphological findings as well as the protein composition of the blister fluid were investigated on the basis of a relevant autopsy case. Analogous to blisters associated with hanging marks, the transudation of serous fluid with consecutive detachment of the epidermis is interpreted as a pressure-related effect which cannot be regarded as a sign of vitality. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  8. Theoretical Study on Synchronous Characterization of Surface and Interfacial Mechanical Properties of Thin-Film/Substrate Systems with Residual Stress Based on Pressure Blister Test Technique

    Directory of Open Access Journals (Sweden)

    Zhi-xin Yang

    2018-01-01

    Full Text Available In this study, based on the pressure blister test technique, a theoretical study on the synchronous characterization of surface and interfacial mechanical properties of thin-film/substrate systems with residual stress was presented, where the problem of axisymmetric deformation of a blistering film with initial stress was analytically solved and its closed-form solution was presented. The expressions to determine Poisson’s ratios, Young’s modulus, and residual stress of surface thin films were derived; the work done by the applied external load and the elastic energy stored in the blistering thin film were analyzed in detail and their expressions were derived; and the interfacial adhesion energy released per unit delamination area of thin-film/substrate (i.e., energy release rate was finally presented. The synchronous characterization technique presented here has theoretically made a big step forward, due to the consideration for the residual stress in surface thin films.

  9. Triglyceride blisters in lipid bilayers: implications for lipid droplet biogenesis and the mobile lipid signal in cancer cell membranes.

    Directory of Open Access Journals (Sweden)

    Himanshu Khandelia

    Full Text Available Triglycerides have a limited solubility, around 3%, in phosphatidylcholine lipid bilayers. Using millisecond-scale course grained molecular dynamics simulations, we show that the model lipid bilayer can accommodate a higher concentration of triolein (TO than earlier anticipated, by sequestering triolein molecules to the bilayer center in the form of a disordered, isotropic, mobile neutral lipid aggregate, at least 17 nm in diameter, which forms spontaneously, and remains stable on at least the microsecond time scale. The results give credence to the hotly debated existence of mobile neutral lipid aggregates of unknown function present in malignant cells, and to the early biogenesis of lipid droplets accommodated between the two leaflets of the endoplasmic reticulum membrane. The TO aggregates give the bilayer a blister-like appearance, and will hinder the formation of multi-lamellar phases in model, and possibly living membranes. The blisters will result in anomalous membrane probe partitioning, which should be accounted for in the interpretation of probe-related measurements.

  10. Churg-Strauss syndrome with coexistence of eosinophilic vasculitis, granulomatous phlebitis and granulomatous dermatitis in bullous pemphigoid-like blisters.

    Science.gov (United States)

    Ishibashi, Masafumi; Kudo, Saori; Yamamoto, Kyoko; Shimai, Nobuko; Chen, Ko-Ron

    2011-03-01

    The main histopathological features in the cutaneous lesions of Churg-Strauss syndrome (CSS) are dermal leukocytoclastic vasculitis with a variable eosinophilic infiltrate and non-vasculitic tissue eosinophilia with granuloma formation. This wide histopathological spectrum may account for the various skin manifestations of CSS. However, the unique histopathological combination of dermal eosinophilic vasculitis and subcutaneous granulomatous phlebitis accompanied by bulla formation has not been previously described. We report an unusual CSS case showing dermal necrotizing eosinophilic vasculitis and granulomatous phlebitis in purpuric lesions coupled with subepidermal blistering. The blisters showed dermal granulomatous dermatitis and eosinophilia without evidence of vasculitis. Dermal necrotizing eosinophilic vasculitis was characterized by fibrinoid alteration of the vessel wall, a prominent perivascular eosinophilic infiltrate, a few infiltrating histiocytes along the affected vessel wall, and the absence of neutrophilic infiltration. The underlying subcutaneous granulomatous phlebitis was characterized by an angiocentric histiocytic infiltrate surrounded by marked eosinophilic infiltrate. Deposition of cytotoxic proteins and radicals derived from eosinophils in the vessel walls and papillary dermis followed by a secondary granulomatous response may account for the unique clinical and histopathological features in this case. Copyright © 2010 John Wiley & Sons A/S.

  11. Cytoskeleton and pericellular matrix organization of pure adult human keratinocytes cultured from suction-blister roof epidermis.

    Science.gov (United States)

    Kariniemi, A L; Lehto, V P; Vartio, T; Virtanen, I

    1982-12-01

    Pure adult human keratinocyte cultures were raised from suction-blister roof epidermis and cultured in MCDB-151 medium. In primary culture the epidermal cells rapidly adhered, spread and began to proliferate on collagen-coated growth substrata but not on uncoated plastic or glass substrata. A fibrillar keratin-specific fluorescence, showing a typical cell-cell arrangement, was seen in all cells in indirect immunofluorescence microscopy, whereas only some cells also showed vimentin-specific staining. A fine fibrillar fibronectin-specific surface staining was seen at the margin of attaching cells and in marginal cells of spreading cell islands, whereas no fluorescence could be seen in epidermal cells, with antibodies against type IV collagen or laminin. Interestingly, the marginal cells also showed intracellular fibronectin. The synthesis of fibronectin in epidermal cell cultures could also be revealed by metabolic labelling experiments with [35S]methionine. In contrast to primary cultures, subcultivated keratinocytes also adhered to uncoated plastic and glass substrata. After subcultivation, keratin and surface fibronectin distribution remained unaltered but after some subcultivations, most of the cells also showed fibrillar vimentin and expressed fibronectin intracellularly. The results show that the suction-blister method provides an easy way to obtain pure epidermal cell cultures without contaminating mesenchymal cells. Our results also suggest a direct role for fibronectin but not for collagen type IV or laminin in adhesion and spreading of epidermal cells in vitro.

  12. CYCLO-OXYGENASE 2 IS PRESENT IN THE MAJORITY OF LESIONAL SKIN FROM PATIENTS WITH AUTOINMUNE BLISTERING DISEASES

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2013-10-01

    Full Text Available Introduction: The in situ immune response within skin biopsies from patients affected by autoimmune skin blistering diseases (ABDs is not well characterized. Aim: Based on the fact that the ABD immune response is considered an adaptive immune response, both an innate immune response and inflammation would be expected in these diseases. Our investigation investigates the presence of cyclo-oxygenase-2 (COX-2, since this enzyme is commonly involved in innate immune responses. Methods: We utilized immunohistochemistry (IHC to evaluate the presence of COX-2 in lesional skin biopsies of patients affected by ABDs. We tested 30 patients with endemic pemphigus foliaceus (EPF, 15 controls from the endemic area, and 15 biopsies from healthy controls from the USA. We also tested archival biopsies from patients with selected ABDs, including 20 patients with bullous pemphigoid, 20 with pemphigus vulgaris, 8 with pemphigus foliaceus and 12 with dermatitis herpetiformis. Results: Most ABD biopsies stained positive for COX-2 in the lesional blister and/or the dermal inflammatory infiltrate, accentuated in the upper neurovascular plexus. In BP and EPF, the COX-2 staining was also seen in the sweat glands. All controls were negative. Conclusions: We document that COX-2 is expressed in lesional skin of patients with ABDs.

  13. White pine blister rust resistance in North American, Asian and european species - results from artificial inoculartion trials in Oregon

    Directory of Open Access Journals (Sweden)

    R.A. Sniezko

    2013-12-01

    Full Text Available Dorena Genetic Resource Center (DGRC has used artificial inoculation trials to evaluate progenies of thousands of Pinus monticola and P. lambertiana selections from Oregon and Washington for resistance to white pine blister rust caused by Cronartium ribicola. In addition, early results are now available for P. albicaulis and P. strobiformis. DGRC has also recently evaluated seed orchard progenies of P. strobus, as well as bulked seedlots from P. armandii and P. peuce. The majority of P. monticola, P. lambertiana, P. albicaulis, and P. strobus progenies are very susceptible to blister rust. However, resistance exists in all these species. P. strobiformis showed relatively high levels of resistance for the eight progenies tested. Resistance in P. armandii was mainly reflected in the very low percentage of cankered seedlings; for P. peuce, the high percentage of cankered seedlings alive three years after inoculation was notable. R-genes are present in some of the North American five-needle pine species, but partial resistance traits (e.g. bark reaction will play a major role in breeding activities for P. monticola and P. lambertiana and will likely be the key to developing durable resistance.

  14. Correlation between blister skin thickness, the maximum in the damage-energy distribution, and projected ranges of He+ ions in metals: Nb

    International Nuclear Information System (INIS)

    Kaminsky, M.; Das, S.K.; Fenske, G.

    1975-01-01

    The skin thicknesses of blisters formed on niobium by helium-ion irradiation at room temperature for energies from 100 to 1500 keV have been measured. The projected ranges of helium ions in Nb for this energy range were calculated using either Brice's formalism or the one given by Schiott. For the damage-energy distribution Brice's formalism was used. The measured skin-thickness values corrleate more closely with the maxima in the projected-range probability distributions than with the maxima in the damage-energy distributions. The results are consistent with our model for blister formation and rupture proposed earlier

  15. CD1a, HAM56, CD68 and S-100 are present in lesional skin biopsies from patients affected by autoimmune blistering diseases

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2014-04-01

    Full Text Available Introduction: Previous research on autoimmune skin blistering diseases (ABD has primarily focused on the humoral immune response; moreover, little attention has been given to the potential role of the antigen presenting cells (APCs in lesional skin. Aim: The purpose of our study was to immunophenotype selected APC in the lesional skin of ABDs, utilizing immunohistochemistry (IHC stains. Materials and Methods: We utilized IHC to stain for dendritic cells (DC, staining with CD1a, CD68, HAM56, and S-100 in lesional skin from 30 patients with endemic pemphigus foliaceus (EPF, 15 controls from the EPF endemic area, and 15 healthy controls from the USA. We also tested archival biopsies from patients with selected ABD, including 30 patients with bullous pemphigoid (BP, 20 with pemphigus vulgaris (PV, 8 with pemphigus foliaceus (PF and 14 with dermatitis herpetiformis (DH and 2 with epidermolysis bullosa acquisita (EBA. Results: Cells stained by CD68, HAM56 and S-100 were present in the majority of the ABD skin biopsies; these cells were located primarily in perivascular infiltrates surrounding dermal vessels subjacent to the blisters. However, these cells were also noted within the blisters, in vessels supplying dermal eccrine glands and ducts, and in areas of dermal endothelial-mesenchymal cell junction-like structures, especially in BP cases. In our CD1a staining, the number and location of positive staining cells varied with each disease, being abundant in most ABD in the epidermis suprajacent to the blisters, or in the epidermis surrounding the blister site if the blister site epidermis was missing. In the control biopsies, most did not display positive IHC staining, with the exception of a few CD1a positive cells in the epidermis Conclusion: Our findings confirm positive IHC staining for APCs in areas of the skin besides the disease blisters. Our findings suggest that the antigen presentation in ABD proceeds in areas distant from the blister site

  16. Synoptic climatology of the long-distance dispersal of white pine blister rust II. Combination of surface and upper level conditions

    Science.gov (United States)

    K. L. Frank; B. W. Geils; L. S. Kalkstein; H. W. Thistle

    2008-01-01

    An invasive forest pathogen, Cronartium ribicola, white pine blister rust (WPBR), is believed to have arrived in the Sacramento Mountains of south-central New Mexico about 1970. Epidemiological and genetic evidence supports the hypothesis that introduction was the result of long-distance dispersal (LDD) by atmospheric transport from California. This...

  17. Dynamics of hydrogen induced blistering of a low carbon steel sheet by lamb waves analysis; Ramuha no teiryo kaiseki ni yoru hakubanteitansoko no suiso hare no dainamikkusu

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Teruyoshi.; Takemoto, Mikio. [Aoyama Gakuin University, Tokyo (Japan). Faculty of Science and Engineering

    1999-06-15

    With the aim of studying the fracture dynamics of environmentally assisted fractures in thin plates, we developed a new source simulation method of the zeroth-order symmetric (or S{sub 0}-) Lamb wave using the experimental overall-transfer function of the system. The transfer function was determined by the time-domain deconvolution of detected S{sub 0}-Lamb component by the artificial fracture source of a compression -type PZT element whose vibration kinetics was estimated by the iteration so that the S{sub o}-waveform detected. Hydrogen induced blistering was found to be caused by the succession of fast Mode-I fracture with source rise times from 0.6 to 1.0{mu}s. The crack volume estimated by the source simulation corresponded to that of fine blistering with an opening displacement of 5{mu}m. As the estimated fracture kinetics of hydrogen blistering coincide with those of delayed fracture of high tension low alloy steel under tensile loading, the kinetics of first and micro-fractures and blistering induced by hydrogen gas precipitation appears to be independent on the hydrogen solubility and strength of steels, the applied stresses and the orientation of cracks. (author)

  18. First report of the white pine blister rust fungus, Cronartium ribicola, infecting Pinus flexilis on Pine Mountain, Humboldt National Forest, Elko County, northeastern Nevada, U.S.A.

    Science.gov (United States)

    Detlev R. Vogler; Patricia E. Maloney; Tom Burt; Jacob W. Snelling

    2017-01-01

    In 2013, while surveying for five-needle white pine cone crops in northeastern Nevada, we observed white pine blister rust, caused by the rust pathogen Cronartium ribicola Fisch., infecting branches and stems of limber pines (Pinus flexilis James) on Pine Mountain (41.76975°N, 115.61622°W), Humboldt National Forest,...

  19. Mobile health (mHealth) based medication adherence measurement - a pilot trial using electronic blisters in diabetes patients.

    Science.gov (United States)

    Brath, Helmut; Morak, Jürgen; Kästenbauer, Thomas; Modre-Osprian, Robert; Strohner-Kästenbauer, Hermine; Schwarz, Mark; Kort, Willem; Schreier, Günter

    2013-09-01

    The aim of the present study was to evaluate a mobile health (mHealth) based remote medication adherence measurement system (mAMS) in elderly patients with increased cardiovascular risk treated for diabetes, high cholesterol and hypertension. Cardiovascular risk was defined as the presence of at least two out of the three risk factors: type 2 diabetes, hypercholesterolaemia and hypertension. For treatment of diabetes, hypercholesterolaemia and hypertension, four predefined routinely used drugs were selected. Drug adherence was investigated in a controlled randomized doctor blinded study with crossover design. The mAMS was used to measure and improve objectively the adherence by means of closed-loop interactions. The mean age of the 53 patients (30 female) was 69.4 ± 4.8 years. A total of 1654 electronic blisters were handed out. A statistically significant difference (P = 0.04) between the monitoring and the control phase was observed for the diabetes medication only. In a post-study questionnaire twenty-nine patients appreciated that their physician knew if and when they had taken their medications and 13 asked for more or automated communication with their physicians. Only one subject withdrew from the study because of technical complexity. The results indicate that mHealth based adherence management is feasible and well accepted by patients with increased cardiovascular risk. It may help to increase adherence, even in patients with high baseline adherence and, subsequently, lead to improved control of indicators including blood pressure and cholesterol concentrations. Electronic blisters can be used in a multi-medication regimen but need to be carefully designed for day-to-day application. © 2013 The British Pharmacological Society.

  20. Effect of litter quality on foot pad dermatitis, hock burns and breast blisters in broiler breeders during the production period.

    Science.gov (United States)

    Kaukonen, Eija; Norring, Marianna; Valros, Anna

    2016-12-01

    Foot pad dermatitis and hock burn lesions are a form of contact dermatitis, a condition affecting skin areas in contact with unsuitable or irritating material. Contact dermatitis is a common problem, reducing the welfare of broilers, and is believed to also affect broiler breeders. However, there is very little research on contact dermatitis in breeders. This study followed the severity of foot pad lesions in broiler breeders throughout the production period. At slaughter the presence of hock burns and breast blisters was also determined. In addition, changes in litter condition over time and the impact of litter quality on foot pads were evaluated. The study was performed on 10 broiler breeder farms, including altogether 18 flocks. Foot pads of 100 hens per flock were assessed at the end of rearing period, three times during the production period, and at slaughter. Foot pad and hock lesions, as well as litter condition were scored on a 5-point scale. Litter quality was evaluated as pH, moisture and ammonia content. The condition of foot pads deteriorated towards slaughter age, with the occurrence of severe lesions reaching a maximum of 64% on average at slaughter. Hock lesions and breast blisters were rare. The litter layer became drier over time. Although poorer litter condition and wetness influenced foot pad health negatively, the effect on severe lesions was not significant. We also observed a negative effect on foot pad condition of larger slat areas. In conclusion, maintaining good litter quality alone is not enough to ensure healthy foot pads in broiler breeders.

  1. Intercomparison of techniques for inspection and diagnostics of heavy water reactor pressure tubes. Determination of hydrogen concentration and blister characterization

    International Nuclear Information System (INIS)

    2009-03-01

    Heavy water reactors (HWRs) comprise significant numbers of today's operating nuclear power plants, and more are under construction. Efficient and accurate inspection and diagnostic techniques for various reactor components and systems, especially pressure tubes, are an important factor in ensuring reliable and safe plant operation. To foster international collaboration in the efficient and safe use of nuclear power, the IAEA conducted a Coordinated Research Project (CRP) on Intercomparison of Techniques for HWR Pressure Tube Inspection and Diagnostics. This CRP was carried out within the framework of the IAEA's Technical Working Group on Advanced Technologies for HWRs (the TWG-HWR). The TWG-HWR is a group of experts nominated by their governments and designated by the IAEA to provide advice and to support implementation of IAEA's project on advanced technologies for HWRs. The objective of the CRP was to compare non-destructive inspection and diagnostic techniques, in use and being developed, for structural integrity assessment of HWR pressure tubes. During the first phase of this CRP participants investigated the capability of different techniques to detect and characterize flaws. During the second phase participants collaborated to detect and characterize hydride blisters and to determine the hydrogen concentration in zirconium alloys. The intention was to identify the most effective pressure tube inspection and diagnostic methods and to identify further development needs. The organizations which participated in phase 2 of this CRP are: - Comision Nacional de Energia Atomica (CNEA), Argentina; - Atomic Energy of Canada Ltd. (AECL), Chalk River Laboratories (CRL), Canada; - Bhabha Atomic Research Centre (BARC), India; - Korea Atomic Energy Research Institute (KAERI), Republic of Korea; - National Institute for Research and Development for Technical Physics (NIRDTP), Romania; - Nuclear Non-Destructive Testing Research and Services (NNDT), Romania. IAEA-TECDOC-1499

  2. Influence of fillers on hydrogen penetration properties and blister fracture of rubber composites for O-ring exposed to high-pressure hydrogen gas

    Energy Technology Data Exchange (ETDEWEB)

    Yamabe, Junichiro; Nishimura, Shin [Department of Mechanical Science Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan); Research Center for Hydrogen Industrial Use and Storage (HYDROGENIUS), National Institute of Advanced Industrial Science and Technology (AIST), 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan)

    2009-02-15

    Ethylene-propylene rubber (EPDM) and nitrile-butadiene rubber (NBR) composites having carbon black, silica, and no fillers were exposed to hydrogen gas at a maximum pressure of 10 MPa; then, blister tests and the measurement of hydrogen content were conducted. The hydrogen contents of the composites were proportional to the hydrogen pressure, i.e., the behavior of their hydrogen contents follows Henry's law. This implies that hydrogen penetrates into the composite as a hydrogen molecule. The addition of carbon black raised the hydrogen content of the composite, while the addition of silica did not. Based on observations, the blister damages of composites with silica were less pronounced, irrespective of the hydrogen pressures. This may be attributed to their lower hydrogen content and relatively better tensile properties than the others. (author)

  3. TISSUE INHIBITOR OF METALLOPROTEINASE 1, MATRIX METALLOPROTEINASE 9, ALPHA-1 ANTITRYPSIN, METALLOTHIONEIN AND UROKINASE TYPE PLASMINOGEN ACTIVATOR RECEPTOR IN SKIN BIOPSIES FROM PATIENTS AFFECTED BY AUTOIMMUNE BLISTERING DISEASES

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2013-07-01

    Full Text Available Introduction: Proteinases and proteinase inhibitors have been described to play a role in autoimmune skin blistering diseases. We studied skin lesional biopsies from patients affected by several autoimmune skin blistering diseases for proteinases and proteinase inhibitors. Methods: We utilized immunohistochemistry to evaluate biopsies for alpha-1-antitrypsin, human matrix metalloproteinase 9 (MMP9, human tissue inhibitor of metalloproteinases 1 (TIMP-1, metallothionein and urokinase type plasminogen activator receptor (uPAR. We tested 30 patients affected by endemic pemphigus, 30 controls from the endemic area, and 15 normal controls. We also tested 30 biopsies from patients with bullous pemphigoid (BP, 20 with pemphigus vulgaris (PV, 8 with pemphigus foliaceus, and 14 with dermatitis herpetiformis (DH. Results: Contrary to findings in the current literature, most autoimmune skin blistering disease biopsies were negative for uPAR and MMP9. Only some chronic patients with El Bagre-EPF were positive to MMP9 in the dermis, in proximity to telocytes. TIMP-1 and metallothionein were positive in half of the biopsies from BP patients at the basement membrane of the skin, within several skin appendices, in areas of dermal blood vessel inflammation and within dermal mesenchymal-epithelial cell junctions.

  4. Identifying and exploring physical and psychological morbidity and patient and family caregiver resilience following acute wound development and/or wound blistering post orthopaedic surgery: a systematic review.

    Science.gov (United States)

    Ousey, Karen; Edward, Karen-Leigh; Lui, Steve

    2015-02-01

    The aim of this article was to identify the literature that examined and explored physical and psychological morbidity and patient and family caregiver resilience following acute wound development and/or wound blistering post orthopaedic surgery. A systematic review of the literature using the databases MEDLINE, CINAHL and EMBASE was undertaken. The papers were examined using title and abstract for relevance to the primary and secondary outcomes. The primary outcome of interest was family caregiver resilience following acute wound development and/or wound blistering post orthopaedic surgery. The search yielded 275 records after removing any duplicates; eight studies were considered eligible and were reviewed as full text. Following full review, none of the studies was included in this article. To conclude, there were no papers that investigated or examined the concept of resilience in relation to the management of acute post-surgical orthopaedic wounds. Four of the papers identified, following the review process, did discuss quality of life outcomes and how these may be improved following wound development; most papers focused on the management of chronic wounds. It is apparent from the review that there is no evidence currently available that explores patient and family caregiver resilience following acute wound development and/or wound blistering post orthopaedic surgery. © 2013 The Authors. International Wound Journal © 2013 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  5. Non-invasive measurement of reepithelialization and microvascularity of suction-blister wounds with benchmarking to histology

    DEFF Research Database (Denmark)

    Larsen, Heidi Fhaer; Ahlström, Malin Glindvad; Gjerdrum, Lise Mette Rahbek

    2018-01-01

    blister (10 mm) was induced on each buttock in 30 healthy volunteers (15 females:15 males) and de-roofed on day 0. The wounds were randomized to daily treatment with 1.4% zinc sulfate shower gel (n = 20), placebo (n = 20) or control (n = 20). Digital photography coupled with planimetry, transepidermal...... groups but increased more with the placebo than with the zinc shower gel (p = 0.003) or the control treatment (p = 0.002) and correlated (rS = 0.313, p = 0.015) with the inflammatory response on day 4, as determined by histology. Coagulase-negative staphylococci were more common in wounds compared...... with skin (p = 0.002) and was reduced (p = 0.030) with zinc sulfate treatment. Planimetric analysis of digital wound images was not biased (p = 0.234) compared with histology, and TEWL measurements showed no correlation (rS = 0.052, p = 0.691) with epithelialization. Neoepidermal formation, determined...

  6. IN SITU IMMUNE RESPONSE EVALUATION VIA IMMUNOHISTOCHEMISTRY IN SKIN BIOPSIES FROM PATIENTS AFFECTED BY AUTOIMMUNE BLISTERING DISEASES

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2013-11-01

    Full Text Available Introduction: The in situ immune response in skin biopsies from patients affected by autoimmune skin blistering diseases (ABD is not well characterized. Aim: Our investigation attempts to immunophenotype cells in lesional skin in several ABD, utilizing immunohistochemistry (ICH. Methods: We tested by IHC for CD4, CD8, CD19, CD20, CD45, CD56/NCAM, PAX-5, granzyme B, myeloperoxidase, neutrophil elastase, LAT and ZAP-70 in patients affected by ABD. We tested 30 patients with endemic pemphigus foliaceus (EPF, 15 controls from the EPF endemic area, and 15 biopsies from healthy controls from the USA. We also tested archival biopsies from patients with selected ABD, including 30 patients with bullous pemphigoid, 20 with pemphigus vulgaris, 8 with pemphigus foliaceus and 14 with dermatitis herpetiformis. Results: We found a predominantly CD8 positive/CD45 positive T cell infiltrate in all ABD. Our skin biopsies demonstrated consistently positive staining for myeloperoxidase, but negative staining for neutrophil elastase. Most ABD biopsies displayed negative staining for CD4 and B cell markers; natural killer cell markers were also rarely seen. ZAP-70 and LAT were frequently detected. In El Bagre-EPF, a significant fragmentation of T cells in lesional skin was noted, as well as autoreactivity to lymph nodes. Conclusions: The documented T cell and myeloperoxidase staining are indicative of the role of T lymphocytes and neutrophils in lesional biopsies in patients with ABD, in addition to previously documented deposition of B cells, immunoglobulins and complement in situ. In El Bagre-EPF, T cells could also target lymph nodes; however, further studies are needed to confirm this possibility.

  7. Composição, proteólise, capacidade de derretimento e formação de "blisters" do queijo mussarela obtido pelos métodos tradicional e de ultrafiltração: composition, proteolysis, melting capacity and blisters formation Mozzarella by ultrafiltration

    Directory of Open Access Journals (Sweden)

    Patrícia D. Pizaia

    2003-12-01

    Full Text Available O objetivo deste trabalho foi comparar a composição, a proteólise, a capacidade de derretimento e a formação de "blisters" (bolhas em queijos tipo Mussarela fabricados com retentado de leite (MR de fator de concentração volumétrica (FCV de 2,34:1, com um queijo Mussarela padrão (MP fabricado com leite não ultrafiltrado. Foi realizado um ensaio de produção com 3 lotes de MR e um lote de MP. Determinou-se a composição do leite, retentado, soro, água de filagem e queijos e a proteólise, a capacidade de derretimento e a formação de "blisters" nos queijos com 7, 15, 30 e 60 dias de armazenamento refrigerado. MRs apresentaram maiores valores de pH e de porcentagem de cinzas e de proteína total e menores porcentagens de acidez titulável, gordura, gordura no extrato seco e sal quando comparadas a MP. Durante o tempo de estocagem, as MRs apresentaram menor proteólise e capacidade de derretimento, em todas as datas analisadas. A porcentagem de área coberta por 'blisters" na pizza e o diâmetro médio dos mesmos foram maiores na MP durante o primeiro mês de estocagem e depois ambos os tipos de queijos apresentaram comportamentos similares para estes 2 parâmetros.The objective of this research was to compare the composition, proteolysis, melting capacity and blisters formation in Mozzarella cheese manufactured with milk retentate (MR of a volumetric concentration factor (FCV of 2.34:1, with a standard Mozzarella cheese (MP manufactured with non ultrafiltrated milk. It was realized one production assay with 3 batches of MRs and one of MP. It was evaluated the milk, retentate, whey, stretching water and cheeses composition and the proteolysis, melting capacity and the blisters formation on cheeses with 7, 15, 30 and 60 days of refrigerates storage. MRs presented larger pH, ash and total protein contents and lower titratable acidity and fat, fat on dry matter and salt contents when compared to MP. Along the storage time the MRs

  8. The viability of PVC/Al blister reuse and PVC property studies after ionizing radiation processing; Viabilizacao do reaproveitamento dos 'blister' de PVC/Al e estudos das propriedades do PVC apos processamento por radiacao ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Alex Terela Pinheiro de

    2008-07-01

    The objective of this research was to separate, by means of a process of dissolution, the PVC and the aluminum that compose blister packs, generally used for pharmaceutical pills. We also studied the effect of the ionizing radiation on the PVC, and, finally, the mechanical recycling of the separated PVC, by a process of extrusion. The material we used in this work is the surplus of the pharmaceutical industry, i.e., packs with defects or burrs. We ground the material to facilitate the handling and the homogenization of the system. After that, we chose two bases for the dissolution of the aluminum: the sodium hydroxide and the potassium hydroxide. We used a system with two concentrations (1 and 2M) for each base, and for every solution we had also an agitated and a non-agitated process. From this method resulted eight experiments. After the dissolution, the samples of the material were submitted to ionizing radiation with doses of 50, 100, 150 and 200 kGy in the Dynamitron II electron accelerator of the CTR-IPEN/CNEN-SP. In the following, these samples were submitted to traction resistance tests to analyze which modifications the irradiation caused. The last step of the research was the recycling of the PVC separated from the Aluminum. We made the recycling in industrial equipment, a PVC tube extruder. The material was combined with lubricants, heat stabilizers and pigment in an intensive mixer and processed into the form of rigid PVC electrical conduits. After the eight experiments, the system with potassium hydroxide base, concentration of 2M and agitation presented the best relation between time of dissolution and characteristics of the resulting material, without degradation of the PVC. In the irradiated samples, the color of the material changed as well as its extension that was as larger as the dose of irradiation they received, indicating the dissociation of the PVC molecules. The extrusion of the PVC was successfully realized: about 200 kg (440 pounds) of

  9. Correlation between blister skin thickness, the maximum in the damage-energy distribution, and the projected ranges of He+ ions in metals

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminsky, M.; Fenske, G.

    1976-01-01

    The skin thickness of blisters formed on aluminium by helium-ion irradiation at room temperature for energies from 100 to 1000 keV have been measured. The projected ranges of helium ions in Al for this energy range were calculated using either Brice's formalism (Brice, D.K., 1972, Phys. Rev., vol. A6, 1791) or the one given by Schioett (Schioett, H.E., 1966, K. Danske Vidensk.Selsk., Mat.-Fys. Meddr., vol.35, No.9). For the damage-energy distribution Brice's formalism was used. The measured skin thickness values are smaller than the calculated values of the maxima in the projected range distributions over the entire energy range studied. These results on the ductile metal aluminium are contrasted with the results on relatively brittle refractory metals V and Nb where the measured skin thickness values correlate more closely with the maxima in the projected range probability distributions than with the maxima in the damage-energy distributions. Processes affecting the blister skin fracture and the skin thickness are discussed. (author)

  10. Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Niehof Sjoerd

    2006-11-01

    Full Text Available Abstract Background In complex regional pain syndrome type 1 (CRPS1 pro-inflammatory mediators and vascular changes play an important role in the sustained development and outcome of the disease. The aim of this study was to determine the involvement of vasoactive substances endothelin-1 (ET-1 and nitric oxide (NO during early chronic CRPS1. Methods Included were 29 patients with CRPS 1 who were diagnosed during the acute stage of their disease and observed during follow-up visits. Disease activity and impairment were determined and artificial suction blisters were made on the CRPS1 and the contralateral extremities for measurements of IL-6, TNF-α, ET-1 and nitrate/nitrite (NOx. Results The levels of IL-6, TNF-α and ET-1 in blister fluid in the CRPS1 extremity versus the contralateral extremity were significantly increased and correlated with each other, whereas NOx levels were decreased. Conclusion The NOx/ET-1 ratio appears to be disturbed in the intermediate stage of CRPS, resulting in vasoconstriction and consequently in a diminished tissue blood distribution.

  11. A Case of Ruptured Blood Blister-like Aneurysm Treated with Pipeline Embolization Device: Clinical Significance of Fetal-type Posterior Communicating Artery.

    Science.gov (United States)

    Park, Ki-Su; Kang, Dong-Hun; Son, Won-Soo; Park, Jaechan; Kim, Young-Sun; Kim, Byung Moon

    2017-03-01

    Blood-blister like aneurysms (BBAs) are challenging lesions because of their wide fragile neck. Flow-diverting stents (FDSs), such as the Pipeline Embolization Device (PED), have been applied to treat BBAs less amenable to more established techniques of treatment. However, the use of FDSs, including the PED, in acute subarachnoid hemorrhage (SAH) still remains controversial. We report a case of aneurysm regrowth following PED application for a ruptured BBA that overlapped the origin of the dominant posterior communicating artery (PCoA), which was successfully treated after coil trapping of the origin of the fetal-type PCoA. And, we discuss the clinical significance of the fetal-type PCoA communicating with a BBA in terms of PED failure.

  12. Exfoliation of oxide in bar: estimation of the geometry of HZ{sub r} blister; Exfoliacion de oxido en barra: estimacion de la geometria de la ampolla de HZ{sub r}

    Energy Technology Data Exchange (ETDEWEB)

    Ramos Calvo, A.; Munoz-Reja, C.; Nicolas Garcia, E.

    2013-07-01

    This paper presents a method to model the formation of a blister of HZ{sub r}. The method consists of two distinct parts. First is a study of the temperature distribution in the pod different configurations of loss of thickness of oxide fuel to define the likely distribution of hydrides geometry. Second is an engineering approach to solving the equation of precipitation of hydrides in the sheath.

  13. Correlation between blister skin thickness, the maximum in the damage-energy distribution, and projected ranges of helium ions in Nb for the energy range 10 to 1500 keV

    International Nuclear Information System (INIS)

    St-Jacques, R.G.; Martel, J.G.; Terreault, B.; Veilleux, G.; Das, S.K.; Kaminsky, M.; Fenske, G.

    1976-01-01

    The skin thickness of blisters formed on polycrystalline niobium by 4 He + irradiation at room temperature for energies from 15 to 80 keV have been measured. Similar measurements were conducted for 10 keV 4 He + irradiation at 500 0 C to increase blister exfoliation, and thereby allow examination of a larger number of blister skins. For energies smaller than 100 keV the skin thicknesses are compared with the projected range and the damage-energy distributions constructed from moments interpolated from Winterbon's tabulated values. For energies of 10 and 15 keV the projected ranges and damage-energy distributions have also been computed with a Monte Carlo program. For energies larger than 100 keV the projected ranges of 4 He + in Nb were calculated using either Brice's formalism or the one given by Schiott. The thicknesses for 60 and 80 keV, and those reported earlier for 100 to 1500 keV correlate well with calculated projected ranges. For energies lower than 60 keV the measured thicknesses are larger than the calculated ranges

  14. Enhanced resistance to blister blight in transgenic tea (Camellia sinensis [L.] O. Kuntze) by overexpression of class I chitinase gene from potato (Solanum tuberosum).

    Science.gov (United States)

    Singh, H Ranjit; Deka, Manab; Das, Sudripta

    2015-07-01

    Tea is the second most consumed beverage in the world. A crop loss of up to 43 % has been reported due to blister blight disease of tea caused by a fungus, Exobasidium vexans. Thus, it directly affects the tea industry qualitatively and quantitatively. Solanum tuberosum class I chitinase gene (AF153195) is a plant pathogenesis-related gene. It was introduced into tea genome via Agrobacterium-mediated transformation with hygromycin phosphotransferase (hpt) gene conferring hygromycin resistance as plant selectable marker. A total of 41 hygromycin resistant plantlets were obtained, and PCR analysis established 12 plantlets confirming about the stable integration of transgene in the plant genome. Real-time PCR detected transgene expression in four transgenic plantlets (T28, C57, C9, and T31). Resistance to biotrophic fungal pathogen, E. vexans, was tested by detached leaf infection assay of greenhouse acclimated plantlets. An inhibitory activity against the fungal pathogen was evident from the detached leaves from the transformants compared with the control. Fungal lesion formed on control plantlet whereas the transgenic plantlets showed resistance to inoculated fungal pathogen by the formation of hypersensitivity reaction area. This result suggests that constitutive expression of the potato class I chitinase gene can be exploited to improve resistance to fungal pathogen, E. vexans, in economical perennial plantation crop like tea.

  15. Microstructural characterization of an irradiated RERTR-6 U-7Mo/AA4043 alloy dispersion fuel plate specimen blister-tested to a final temperature of 500 °C

    Science.gov (United States)

    Keiser, Dennis D.; Jue, Jan-Fong; Gan, Jian; Miller, Brandon D.; Robinson, Adam B.; Madden, James W.; Ross Finlay, M.; Moore, Glenn; Medvedev, Pavel; Meyer, Mitch

    2017-05-01

    The Material Management and Minimization (M3) Reactor Conversion Program, in the past called the Reduced Enrichment for Research and Test Reactor (RERTR) Program, is developing low-enriched uranium (LEU) fuels for application in research and test reactors. U-Mo alloy dispersion fuel is one type being developed. Blister testing has been performed on different fuel plate samples to determine the margin to failure for fuel plates irradiated to different fission densities. Microstructural characterization was performed using scanning electron microscopy and transmission electron microscopy on a sample taken from a U-7Mo/AA4043 matrix dispersion fuel plate irradiated in the RERTR-6 experiment that was blister-tested up to a final temperature of 500 °C. The results indicated that two types of grain/cell boundaries were observed in the U-7Mo fuel particles, one with a relatively low Mo content and fission gas bubbles and a second type enriched in Si, due to interdiffusion from the Si-containing matrix, with little evidence of fission gas bubbles. With respect to the behavior of the major fission gas Xe, a significant amount of the Xe was still observed within the U-7Mo fuel particle, along with microns into the AA4043 matrix. For the fuel/matrix interaction layers that form during fabrication and then grow during irradiation, they change from the as-irradiated amorphous structure to one that is crystalline after blister testing. In the AA4043 matrix, the original Si-rich precipitates, which are typically observed in as-irradiated U-Mo dispersion fuel, get consumed due to interdiffusion with the U-7Mo fuel particles during the blister test. Finally, the fission gas bubbles that were originally around 3 nm in diameter and resided on a fission gas superlattice (FGS) in the intragranular regions of as-irradiated U-7Mo fuel grew in size (up to ∼20 nm diameter) during blister testing and, in many areas, are no longer organized as a superlattice.

  16. Microstructural characterization of an irradiated RERTR-6 U-7Mo/AA4043 alloy dispersion fuel plate specimen blister-tested to a final temperature of 500 °C

    Energy Technology Data Exchange (ETDEWEB)

    Keiser, Dennis D., E-mail: dennis.keiser@inl.gov [Nuclear Fuels and Materials Division, Idaho National Laboratory, P. O. Box 1625, Idaho Falls, ID 83415-6146 (United States); Jue, Jan-Fong; Gan, Jian; Miller, Brandon D.; Robinson, Adam B.; Madden, James W. [Nuclear Fuels and Materials Division, Idaho National Laboratory, P. O. Box 1625, Idaho Falls, ID 83415-6146 (United States); Ross Finlay, M. [Australian Nuclear Science and Technology Organization, PMB 1, Menai, NSW 2234 (Australia); Moore, Glenn; Medvedev, Pavel; Meyer, Mitch [Nuclear Fuels and Materials Division, Idaho National Laboratory, P. O. Box 1625, Idaho Falls, ID 83415-6146 (United States)

    2017-05-15

    The Material Management and Minimization (M3) Reactor Conversion Program, in the past called the Reduced Enrichment for Research and Test Reactor (RERTR) Program, is developing low-enriched uranium (LEU) fuels for application in research and test reactors. U–Mo alloy dispersion fuel is one type being developed. Blister testing has been performed on different fuel plate samples to determine the margin to failure for fuel plates irradiated to different fission densities. Microstructural characterization was performed using scanning electron microscopy and transmission electron microscopy on a sample taken from a U-7Mo/AA4043 matrix dispersion fuel plate irradiated in the RERTR-6 experiment that was blister-tested up to a final temperature of 500 °C. The results indicated that two types of grain/cell boundaries were observed in the U-7Mo fuel particles, one with a relatively low Mo content and fission gas bubbles and a second type enriched in Si, due to interdiffusion from the Si-containing matrix, with little evidence of fission gas bubbles. With respect to the behavior of the major fission gas Xe, a significant amount of the Xe was still observed within the U-7Mo fuel particle, along with microns into the AA4043 matrix. For the fuel/matrix interaction layers that form during fabrication and then grow during irradiation, they change from the as-irradiated amorphous structure to one that is crystalline after blister testing. In the AA4043 matrix, the original Si-rich precipitates, which are typically observed in as-irradiated U-Mo dispersion fuel, get consumed due to interdiffusion with the U-7Mo fuel particles during the blister test. Finally, the fission gas bubbles that were originally around 3 nm in diameter and resided on a fission gas superlattice (FGS) in the intragranular regions of as-irradiated U-7Mo fuel grew in size (up to ∼20 nm diameter) during blister testing and, in many areas, are no longer organized as a superlattice.

  17. Colonization history, host distribution, anthropogenic influence and landscape features shape populations of white pine blister rust, an invasive alien tree pathogen.

    Directory of Open Access Journals (Sweden)

    Simren Brar

    Full Text Available White pine blister rust is caused by the fungal pathogen Cronartium ribicola J.C. Fisch (Basidiomycota, Pucciniales. This invasive alien pathogen was introduced into North America at the beginning of the 20th century on pine seedlings imported from Europe and has caused serious economic and ecological impacts. In this study, we applied a population and landscape genetics approach to understand the patterns of introduction and colonization as well as population structure and migration of C. ribicola. We characterized 1,292 samples of C. ribicola from 66 geographic locations in North America using single nucleotide polymorphisms (SNPs and evaluated the effect of landscape features, host distribution, and colonization history on the structure of these pathogen populations. We identified eastern and western genetic populations in North America that are strongly differentiated. Genetic diversity is two to five times higher in eastern populations than in western ones, which can be explained by the repeated accidental introductions of the pathogen into northeastern North America compared with a single documented introduction into western North America. These distinct genetic populations are maintained by a barrier to gene flow that corresponds to a region where host connectivity is interrupted. Furthermore, additional cryptic spatial differentiation was identified in western populations. This differentiation corresponds to landscape features, such as mountain ranges, and also to host connectivity. We also detected genetic differentiation between the pathogen populations in natural stands and plantations, an indication that anthropogenic movement of this pathogen still takes place. These results highlight the importance of monitoring this invasive alien tree pathogen to prevent admixture of eastern and western populations where different pathogen races occur.

  18. Sensibilidade de Colletotrichum gloeosporioides (mancha manteigosa do cafeeiro a diferentes concentrações de fungicidas Sensibility of Colletotrichum gloeosporioides (coffee blister spot to different fungicide concentrations

    Directory of Open Access Journals (Sweden)

    Josimar Batista Ferreira

    2009-01-01

    Full Text Available Com o objetivo de avaliar a eficiência de alguns fungicidas sobre Colletotrichum gloeosporioides, agente etiológico da mancha manteigosa do cafeeiro (Coffea arabica L., testes in vitro foram conduzidos no Laboratório de Diagnose e Controle/UFLA. Utilizou-se o método de incorporação de fungicidas ao meio de cultura MEA 2% para a avaliação da inibição do crescimento micelial e em lâmina escavada contendo água com fungicida para a germinação de conídios. Os fungicidas, tetraconazol, triadimenol, chlorotalonil e mancozeb foram testados quanto à inibição do crescimento do micelial (nas concentrações de 1, 5, 10, 25, 50, 100, 500 e 1.000 mg L-1 e quanto à inibição da germinação de conídios (nas concentrações de 1, 5, 10, 25, 50 e 100 mg L-1. Os fungicidas tetraconazol e triadimenol apresentaram alta eficiência na inibição do crescimento micelial. Os fungicidas chlorotalonil e mancozeb mostraram baixa eficiência e ineficiência, respectivamente. Quanto à germinação dos conídios, os fungicidas que demonstraram maior eficiência em baixas concentrações foram o chlorotalonil e o tetraconazol.With the aim of assessing the effect of selected fungicides on Colletotrichum gloeosporioides, the cause of coffee blister spot, in vitro tests were carried out in the Laboratory of Diagnosis and Control/UFLA, Federal University of Lavras, Brazil. In the in vitro experiments the fungicides were incorporated into malt extract medium (MEA 2% to evaluate the effect on the fungus growth rate, and concavity slides containing water plus fungicide to assess the conidia germination. The fungicides tetraconazol, triadimenol, chlorothalonil and mancozeb were tested on the mycelial growth inhibition (in the concentrations of 1, 5, 10, 25, 50, 100, 500 and 1.000 mg L-1 and on the inhibition conidia germination (in the concentrations of 1, 5, 10, 25, 50 e 100 mg L-1. The fungicides tetraconazol and triadimenol showed high efficiency on the

  19. Flow diversion with Pipeline Embolic Device as treatment of subarachnoid hemorrhage secondary to blister aneurysms: dual-center experience and review of the literature.

    Science.gov (United States)

    Linfante, Italo; Mayich, Michael; Sonig, Ashish; Fujimoto, Jena; Siddiqui, Adnan; Dabus, Guilherme

    2017-01-01

    Aneurysmal subarachnoid hemorrhage (aSAH) secondary to blister-type aneurysms (BAs) is associated with high morbidity and mortality. Microsurgical clipping or wrapping and/or use of traditional endovascular techniques to repair the lesion result in frequent regrowth and rebleeds and ultimately high fatality rates. Because of the purely endoluminal nature of arterial reconstruction, flow diversion may represent an ideal option to repair ruptured BAs. We performed a retrospective analysis of our database including all consecutive patients with aSAH secondary to BAs treated with the Pipeline Embolic Device (PED) between November 2013 and November 2015 in two institutions. We collected basic patient demographics, aneurysm size, location, number and sizes of PEDs used, use of coiling, 30-day modified Rankin Scale (mRS) score, and follow-up imaging data. Ten cases of aSAH were found as a result of a ruptured BA. Patients had a mean age of 47.2 years (range 27-68). Mean Hunt and Hess score was 1.6 (range 1-4). Lesions were predominantly left-sided, mostly along the dorsal aspect of the internal carotid artery, either paraclinoid or paraophthalmic (8/10). In two patients the BA was located in the left middle cerebral artery. All lesions were very small (mean 1.4×1.5 mm; range 0.75-2.1 mm). Placement of a single PED resulted in immediate occlusion or near-occlusion of the BA in 9 out of 10 patients. Nine patients did very well; eight had a 90-day mRS score of 0 and one had a 90-day mRS score of 1. Follow-up digital subtraction angiography was performed in all patients (mean 15 months; range 7-24). In the surviving nine patients there was complete occlusion of the BA on long-term follow-up angiography. Repair of ruptured BA with PED may be a safe and durable option. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  20. Effectiveness and side effects of anti-CD20 therapy for autoantibody-mediated blistering skin diseases: A comprehensive survey of 71 consecutive patients from the Initial use to 2007

    Directory of Open Access Journals (Sweden)

    Jennifer D Peterson

    2008-11-01

    Full Text Available Jennifer D Peterson1, Lawrence S Chan2,3,41Department of Dermatology, Texas Tech University Health Sciences Center at Lubbock, Lubbock, TX, USA; 2Department of Dermatology; 3Department of Microbiology/Immunology, University of Illinois at Chicago, Chicago, IL, USA; 4Medicine Service, Jesse Brown VA Medical Center, Chicago, IL, USAAbstract: In order to examine the efficacy and side effects of the monoclonal antibody anti-CD20 (rituximab on autoimmune blistering skin diseases, we performed a comprehensive survey of 71 consecutive patients from initial use up to 2007, using the PubMed database. A heterogeneous group of patients, including 51 patients with pemphigus vulgaris, one with pemphigus vegetans, nine with pemphigus foliaceus, five with paraneoplastic pemphigus, four with epidermolysis bullosa acquisita, and one with both bullous pemphigoid and graft vs host disease was included in this survey. Overall the monoclonal antibody seems to be effective in that 69% of patients showed complete response, 25% of patients showed partial response, whereas 6% of patients showed progressive disease. Six deaths occurred in association with the treatment, with four of these deaths in patients with paraneoplastic pemphigus, a disease characteristically resistant to conventional medication and with a high mortality rate. Of note, 11 patients who received combined rituximab and intravenous immune globulin treatments had the best outcome: complete response without any serious side effects. Therefore further investigation on rituximab with controlled clinical trial is a worthy pursuit.Keywords: blistering diseases, skin, anti-CD20, pemphigus, epidermolysis bullosa acquisita

  1. Stress analysis of local blisters coupling Raman spectroscopy and X-ray diffraction. Correlation between experimental results and continuous damage modelling for buckling in an iron oxide/phosphated iron system

    Energy Technology Data Exchange (ETDEWEB)

    Panicaud, B., E-mail: benoit.panicaud@utt.fr [Universite de Technologie de Troyes (UTT), CNRS UMR 6279, 12 rue Marie Curie, 10010 Troyes (France); Grosseau-Poussard, J.L. [LEMMA, Pole Sciences et Technologie, Universite de La Rochelle, Av. M. Crepeau, 17042 La Rochelle Cedex (France)

    2010-12-01

    In this present work, local stress development in the iron oxide layers growing on phosphated {alpha}-Fe at 400 deg. C in ambient air is investigated by Raman spectroscopy. Coupled with X-ray diffraction it enables to obtain directly local stresses' maps in the oxide layers. Use of Raman spectroscopy allows obtaining better accuracy on mechanical behaviour at local scale. This characterisation technique is very useful to study systems developing mechanical heterogeneities on surface, especially in case of buckling phenomenon. Investigations on particular local blisters have been done to measure some characteristic lengths at local scale. From local measurements, we are able to evaluate general effect of buckling from simplified scale transition. So, a macroscopic approach has been performed to calculate global stress evolution of the oxide layer, based on continuous damage mechanics. Consequently, it leads to good comparison between modelling and experimental values (global stresses versus oxidation time) in {alpha}-Fe{sub 2}O{sub 3} oxide.

  2. Effect of the order of He{sup +} and H{sup +} ion co-implantation on damage generation and thermal evolution of complexes, platelets, and blisters in silicon

    Energy Technology Data Exchange (ETDEWEB)

    Daghbouj, N. [CEMES-CNRS and Université de Toulouse, 29 rue J. Marvig, 31055 Toulouse (France); Faculté des Sciences de Monastir, Université de Monastir, Monastir (Tunisia); Cherkashin, N., E-mail: nikolay.cherkashin@cemes.fr; Darras, F.-X.; Paillard, V.; Claverie, A. [CEMES-CNRS and Université de Toulouse, 29 rue J. Marvig, 31055 Toulouse (France); Fnaiech, M. [Faculté des Sciences de Monastir, Université de Monastir, Monastir (Tunisia)

    2016-04-07

    Hydrogen and helium co-implantation is nowadays used to efficiently transfer thin Si layers and fabricate silicon on insulator wafers for the microelectronic industry. The synergy between the two implants which is reflected through the dramatic reduction of the total fluence needed to fracture silicon has been reported to be strongly influenced by the implantation order. Contradictory conclusions on the mechanisms involved in the formation and thermal evolution of defects and complexes have been drawn. In this work, we have experimentally studied in detail the characteristics of Si samples co-implanted with He and H, comparing the defects which are formed following each implantation and after annealing. We show that the second implant always ballistically destroys the stable defects and complexes formed after the first implant and that the redistribution of these point defects among new complexes drives the final difference observed in the samples after annealing. When H is implanted first, He precipitates in the form of nano-bubbles and agglomerates within H-related platelets and nano-cracks. When He is implanted first, the whole He fluence is ultimately used to pressurize H-related platelets which quickly evolve into micro-cracks and surface blisters. We provide detailed scenarios describing the atomic mechanisms involved during and after co-implantation and annealing which well-explain our results and the reasons for the apparent contradictions reported at the state of the art.

  3. Clinical Efficacy of Composite Blister Beetle Capsule on Lung Cancer Patients′Immunity%复方斑蝥胶囊对肺癌的疗效及其对免疫水平的影响

    Institute of Scientific and Technical Information of China (English)

    辜斌; 谢佳琳; 林东亮

    2016-01-01

    Objective:To observe the effect of the Composite Blister Beetle Capsule in the treatment of perioperative lung cancer, and to discuss the regulation of immunity.Methods:A total of 90 perioperative lung cancer who were admitted to our department from August 2015-January 2016,were randomly divided into control group and observation group,45 cases in each group.The control group,glucose injection 250 mL intravenous injection,twice a day for 15 days.Observation group were given Composite Blister Beetle Capsule twice a day.After 15 days′treatment,the clinical efficacy of the same treatment,all immune factors score, adverse drug reactions,clinical benefit analysis and serum IL-2,IL-6,IL-10 and TNF-αlevel changes were evaluated.Results:1)After the treatment,the observation group′s effective rate was 88.89%,the control group 77.78,the differences were statisti-cally significant between the two groups(P 0.05),after 15 days′treatment,observation group′s immunized kinetic energy slightly improved,but the treatment experienced no changes compared with the control group,the difference was statistically signif-icant (P 0.05).The observation group has higher stability rate than control group in KPS and body weight change (P 0.05).After 15 days′treatment,the index decreased,but the observation group decreased more significantly.Con-clusion:Composite Blister Beetle Capsule can improve the immunity of lung cancer patients with significant clinical effect and not obvious side effect,which is worthy of clinical promotion.%目的:观察复方斑蝥胶囊在改善肺癌患者免疫力方面的临床疗效,并借此探讨其对各炎性反应因子及免疫因子的影响和机制。方法:选取2015年8月至2016年6月南京军区福州总医院第一附属医院收治的非小细胞肺癌(NSCLC)患者患者90例,随机分成对照组和观察组,每组45例。观察组予口服复方斑蝥胶囊750 mg 口服,3次/d,连用1周(7 d)

  4. How To Prevent and Treat Blisters

    Science.gov (United States)

    ... Registration General information Housing & travel Education Exhibit hall Mobile app 2019 Annual Meeting Derm Exam Prep Course ... SkinPAC State societies Scope of practice Truth in advertising NP/PA laws Action center Public and patients ...

  5. Chemical Blistering: Cellular and Macromolecular Components

    Science.gov (United States)

    1985-12-15

    34’ has been applied. In principle , this experimental technique involves infection ef a permissive host with a virus which is nonvirulent because of...rate of lactate &cowmulation as compared with the control. The ethanol/methyleno chloride mixture Itself appeared to account for a small amount of...D.C., Part III, pp. 479- 518. 6. Ross, W. C. J. (1962) Biologiral Alkylating Agents* Fundmental ChemLsLr and Desi 2f L ds fgr Selive ToxicitX

  6. Intermittency and Inflexibility Blister Pump Impress Factors

    OpenAIRE

    Mlakar, Boštjan; Zupančič, Cvetko

    2011-01-01

    Divisional centralized heating and cooling system, cogeneratton system of heat and power and power-gas cogeneration system. In order to further fully and reasonably use the heat in doubleeffect absorption units, double-stage bubble pump must be involved in the adoption o u pump replacing the traditional mechanical solution pump. It was designed a secon generator based on a solar pump-free lithium bromide absorption chiller system. The expenmen adopts the lunate thermosiphon elevation tube, ef...

  7. The Causes of Blistering in Boat Building Materials

    Science.gov (United States)

    1986-08-01

    acrylate units (MET) Ethylene glycol (MET) Propylene glycol (MET) Neopentyl glycol (NET) Maleic acid or anhydride (unsaturated) (NET) lumaric acid...PROPYLENE GLYCOL OPA ORTHOPHTHALIC ACID VINYL - URETHANE BASED POLYESTER IqPG NEOPENTYL GLYCOL RESIN EG - ETHYLENE GLYCOL TMPD - 22,, - TRiMETHY...IPA Isophthalic acid WSN Low molecular weight water soluble material NPG Neopentyl glycol OPA Orthophthalio acid PG Propylene glycol MEKP Hethyl

  8. Kinetics of the conversion of copper sulfide to blister copper

    Directory of Open Access Journals (Sweden)

    Carrillo, F.

    2002-10-01

    Full Text Available The desulfurization of copper sulfide by air and oxygen has been studied in two laboratory reactors where the gas is blown onto the melt surface. Rates of oxidation in a vertical resistance furnace may be explained by the mass transfer control in the gas phase. However, results for a horizontal tube suggest that the chemical resistance is controlling.

    La desulfuración del sulfuro cuproso con aire y oxígeno se ha estudiado en dos reactores de laboratorio, en los cuales el gas se sopla sobre la superficie del fundido. La velocidad de reacción en un horno de resistencias verticales se puede explicar considerando como controlante la resistencia a la transferencia de materia de la fase gas. Sin embargo, los resultados del horno horizontal indican que la resistencia química es la controlante.

  9. Treatment of acute burn blisters in unscheduled care settings.

    Science.gov (United States)

    Payne, Sarah; Cole, Elaine

    2012-09-01

    Many patients with minor burns present at emergency departments and urgent care centres, where their management is often undertaken by experienced nurses rather than experts in treating burns. This article describes a small study of the clinical decision making that underpins nurses' management of minor burns in these non-specialist settings. The results suggest that, due to a lack of relevant research, nurses base their decisions on previous experience or expert colleagues' opinions and advice rather than on the evidence.

  10. Effect of aqueous vitamin B on the growth of blister blight pathogen, Exobasidium vexans

    Directory of Open Access Journals (Sweden)

    Hideyuki Nagao

    2012-12-01

    Full Text Available The effect of three aqueous solution of biotin, thiamine and calcium pantothenate, on the growth of Exobasidiumvexans was examined in vitro. The germination process of basidiospores of E. vexans differed from those of the otherExobasidium species. Basidiospore germination commenced after 19.5 hr incubation and chlamydospore-like bodies wereformed after 96 hr of incubation. Addition of biotin, calcium pantothenate, and thiamine to Difco PDA and Czapek’s mediumdid not affect the proportion of germinating basidiospores. The length of germ tubes was enhanced only by addition ofthiamine in the media. Larger size germ tubes (thick germ tubes were occasionally observed among the ordinary hyphae.Most germlings of basidiospores developed chlamydospore-like bodies or autolysed on the media. Thick germ tubesfrequently appeared on the calcium pantothenate amended media and developed into a colony when these hyphae weretransferred to new calcium pantothenate amended media. However, further transfer of colonies did not successfully bring anew colony to grow on the calcium pantothenate amended media. Vitamin B5, calcium pantothenate, was only partially effective in generating the thick germ tubes and to induce the initial colony formation, whereas amendment of biotin and thiamineto the media did not induce visible colony growth.

  11. Blistering in alloy Ti–6Al–4V from H + ion implantation

    Indian Academy of Sciences (India)

    6Al–4V, was studied, following H+ ion implantation of 150 keV and 250 keV energy to fluence of 2.6 × 1018 cm-2 and 2.5 × 1019 cm-2, respectively at ambient temperature. No detectable change was observed in surface features of either of the ...

  12. Blister Packaging Medication to Increase Treatment Adherence and Clinical Response: Impact on Suicide-Related Morbidity and Mortality

    Science.gov (United States)

    2013-09-01

    D., Adler, L. E., Ivins, B. J., Helmick, K., & Warden, D. (2010). Neuropsychological test performance in soldiers with blast-related mild TBI... Neuropsychology , 24(2), 160-167. doi:10.1037/a0017966 Selby, E. A., Anestis, M.D., Bender, T. W., Ribeiro, J. D, Nock, M. K. , Rudd, M. D., Bryan, C. J...relationship between physical and/or sexual abuse, attitudes about life and death, and suicidal ideation in young women. Death Studies, 24(8), 675

  13. Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease.

    Directory of Open Access Journals (Sweden)

    Danillo G Augusto

    Full Text Available The KIR genes and their HLA class I ligands have thus far not been investigated in pemphigus foliaceus (PF and related autoimmune diseases, such as pemphigus vulgaris. We genotyped 233 patients and 204 controls for KIR by PCR-SSP. HLA typing was performed by LABType SSO reagent kits. We estimated the odds ratio, 95% confidence interval and performed logistic regression analyses to test the hypothesis that KIR genes and their known ligands influence susceptibility to PF. We found significant negative association between activating genes and PF. The activating KIR genes may have an overlapping effect in the PF susceptibility and the presence of more than three activating genes was protective (OR=0.49, p=0.003. A strong protective association was found for higher ratios activating/inhibitory KIR (OR=0.44, p=0.001. KIR3DS1 and HLA-Bw4 were negatively associated to PF either isolated or combined, but higher significance was found for the presence of both together (OR=0.34, p<10(-3 suggesting that the activating function is the major factor to interfere in the PF pathogenesis. HLA-Bw4 (80I and 80T was decreased in patients. There is evidence that HLA-Bw4(80T may also be important as KIR3DS1 ligand, being the association of this pair (OR=0.07, p=0.001 stronger than KIR3DS1-Bw4(80I (OR=0.31, p=0.002. Higher levels of activating KIR signals appeared protective to PF. The activating KIR genes have been commonly reported to increase the risk for autoimmunity, but particularities of endemic PF, like the well documented influence the environmental exposure in the pathogenesis of this disease, may be the reason why activated NK cells probably protect against pemphigus foliaceus.

  14. Laser pulse duration dependence of blister formation on back-radiated Ti thin films for BB-LIFT

    Czech Academy of Sciences Publication Activity Database

    Goodfriend, N. T.; Starinskiy, S.V.; Nerushev, O. A.; Bulgakova, Nadezhda M.; Bulgakov, A.V.; Campbell, E.E.B.

    2016-01-01

    Roč. 122, č. 3 (2016), s. 1-9, č. článku 154. ISSN 0947-8396 R&D Projects: GA MŠk ED2.1.00/01.0027; GA MŠk LO1602 Grant - others:HILASE(XE) CZ.1.05/2.1.00/01.0027 Institutional support: RVO:68378271 Keywords : mass-spectrometry * nanoparticles * ablation Subject RIV: BH - Optics, Masers, Lasers Impact factor: 1.455, year: 2016

  15. Blister pouches for effective reagent storage and release for low-cost point-of-care diagnostic applications

    CSIR Research Space (South Africa)

    Smith, S

    2016-02-01

    Full Text Available Lab-on-a-chip devices are often applied to point-of-care diagnostic solutions as they are low-cost, compact, disposable, and require only small sample volumes. For such devices, various reagents are required for sample preparation and analysis and...

  16. Return of the giants: Restoring white pine ecosystems by breeding and aggressive planting of blister rust-resistant white pines

    Science.gov (United States)

    Lauren Fins; James Byler; Dennis Ferguson; Al Harvey; Mary Francis Mahalovich; Geral I. McDonald; Dan Miller; John Schwandt; Art Zack

    2001-01-01

    In 1883, when the Northern Pacific Railroad made its way through northern Idaho, western white pines dominated the moist, mid-elevation, mixed-species forests of the Inland Northwest between 2,000 and 6,000 feet. These majestic trees often lived to 350 years but could reach the ripe old ages of 400 and even 500 years. They were an integral part of the most productive...

  17. Radiation blistering of Nb implanted sequentially with helium ions of different energies (3-500 keV)

    International Nuclear Information System (INIS)

    Guseva, M.I.; Gusev, V.; Krasulin, U.L.; Martinenko, U.V.; Das, S.K.; Kaminsky, M.S.

    1976-01-01

    Cold rolled, polycrystalline niobium samples were irradiated at room temperature with 4 He + ions sequentially at 14 different energies over an energy range from 3 keV--500 keV in steps of 50 keV. The dose for each energy was chosen to give an approximately uniform concentration of helium between the implant depths corresponding to 3 keV and 500 keV. In one set of experiments the irradiations were started at the Kurchatov Institute with 3 keV 4 He + ions and extended up to 80 keV in several steps. Subsequently, the same target area was irradiated with 4 He + ions at Argonne National Laboratory (ANL) starting at 100 keV and increased to 500 keV in steps of 50 keV. Another set of irradiations were started at ANL with 500 keV 4 He + ions and continued with decreasing ion energies to 100 keV. Subsequently, the same area was irradiated at the Kurchatov Institute starting at 80 keV and continued with decreasing ion energies to 3 keV. Both sets of irradiations were completed for two different total doses, 0.5 C cm -2 and 1.0 C cm -2

  18. Demographic projection of high-elevation white pines infected with white pine blister rust: a nonlinear disease model

    Science.gov (United States)

    S. G. Field; A. W. Schoettle; J. G. Klutsch; S. J. Tavener; M. F. Antolin

    2012-01-01

    Matrix population models have long been used to examine and predict the fate of threatened populations. However, the majority of these efforts concentrate on long-term equilibrium dynamics of linear systems and their underlying assumptions and, therefore, omit the analysis of transience. Since management decisions are typically concerned with the short term (

  19. First report of the white pine blister rust fungus, Cronartium ribicola, infecting Ribes inerme in north-central Utah

    Science.gov (United States)

    D. R. Vogler; B. W. Geils; K. Coats

    2017-01-01

    Cronartium ribicola Fisch. has not been found infecting any of the five-needle white pines (Pinus subgenus Strobus) in Utah, despite being established on both white pine and Ribes hosts in the other 10 western states, defined as those west of the 102° meridian.

  20. Synoptic climatology of the long-distance dispersal of white pine blister rust I. Development of an upper level synoptic classification

    Science.gov (United States)

    K. L. Frank; L. S. Kalkstein; B. W. Geils; H. W. Thistle

    2008-01-01

    This study developed a methodology to temporally classify large scale, upper level atmospheric conditions over North America, utilizing a newly-developed upper level synoptic classification (ULSC). Four meteorological variables: geopotential height, specific humidity, and u- and v-wind components, at the 500 hPa level over North America were obtained from the NCEP/NCAR...

  1. Caspase-1-Independent IL-1 Release Mediates Blister Formation in Autoantibody-Induced Tissue Injury through Modulation of Endothelial Adhesion Molecules

    NARCIS (Netherlands)

    Sadeghi, Hengameh; Lockmann, Anike; Hund, Anna-Carina; Samavedam, Unni K. S. R. L.; Pipi, Elena; Vafia, Katerina; Hauenschild, Eva; Kalies, Kathrin; Pas, Hendrikus; Jonkman, Marcel F.; Iwata, Hiroaki; Recke, Andreas; Schon, Michael P.; Zillikens, Detlef; Schmidt, Enno; Ludwig, Ralf J.

    2015-01-01

    Although reports documented aberrant cytokine expression in autoimmune bullous dermatoses (AIBDs), cytokine-targeting therapies have not been established in these disorders. We showed previously that IL-6 treatment protected against tissue destruction in experimental epidermolysis bullosa acquisita

  2. Track 1 - fuel fabrication: design, manufacture and automation stress field of blister forming in a metallic fuel and its interaction with clad

    International Nuclear Information System (INIS)

    Singh, A.K.; Hussain, M.M.; Singh, R.P.; Singh, R.N.; Chakravartty, J.K.; Shah, B.K.; Ståhle, P.

    2009-01-01

    One of the most critical components for the nuclear reactor is nuclear fuel. The fuel is subjected to severe environment of temperature, thermal stress, irradiation and corrosion in a reactor and its behaviour is governed by complex interaction of physical, chemical, mechanical and metallurgical processes which become operative in the reactor environment. A good fuel element should perform reliably in a reactor without experiencing any type of failure during its lifetime. Hence, the fabrication of nuclear fuel elements to the stringent quality requirements as demanded by the designers is a highly specialized and sophisticated technology

  3. Tracking the footsteps of an invasive plant pathogen: Intercontinental phylogeographic structure of the white-pine-blister-rust fungus, Cronartium ribicola

    Science.gov (United States)

    Bryce A. Richardson; Mee-Sook Kim; Ned B. Klopfenstein; Yuko Ota; Kwan Soo Woo; Richard C. Hamelin

    2009-01-01

    Presently, little is known about the worldwide genetic structure, diversity, or evolutionary relationships of the white-pineblister-rust fungus, Cronartium ribicola. A collaborative international effort is underway to determine the phylogeographic relationships among Asian, European, and North American sources of C. ribicola and...

  4. Correlation between blister skin thickness, the maximum in the damage-energy distribution, and projected ranges of He+ ions in metals: V

    International Nuclear Information System (INIS)

    Kaminsky, M.; Das, S.K.; Fenske, G.

    1976-01-01

    In these experiments a systematic study of the correlation of the skin thickness measured directly by scanning electron microscopy with both the calculated projected-range values and the maximum in the damage-energy distribution has been conducted for a broad helium-ion energy range (100 keV-1000 keV in polycrystalline vanadium. (Auth.)

  5. Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis

    DEFF Research Database (Denmark)

    Grando, S.A.; Bystryn, J.C.; Chernyavsky, A.I.

    2009-01-01

    of EGF receptor, Src, mTOR, p38 MAPK and other signalling elements downstream of ligated antigens, elevation of intracellular calcium and launching of the cell death cascades. (3) Basal cell shrinkage due to: (i) collapse and retraction of the tonofilaments cleaved by executioner caspases; and (ii...

  6. Measuring of quality of life in autoimmune blistering disorders in Poland. Validation of disease - specific Autoimmune Bullous Disease Quality of Life (ABQOL) and the Treatment Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaires.

    Science.gov (United States)

    Kalinska-Bienias, Agnieszka; Jakubowska, Beata; Kowalewski, Cezary; Murrell, Dedee F; Wozniak, Katarzyna

    2017-03-01

    Autoimmune bullous dermatoses (AIBD) are rare, severe diseases resulting from some antibodies activity against the different adhesion structures within the skin and/or mucosa. Few studies investigated quality of life (QOL) in AIBD by generic and dermatology-specific instruments, all reporting strong impact on QOL. Recently, disease-specific measurement tools have been developed: Autoimmune Bullous Disease Quality of Life (ABQOL) and Treatment of Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaires. The aim of this study was to test the reliability and validity of ABQOL and TABQOL by developing the first foreign language versions and to evaluate ABQOL and TABQOL in Polish patients. The study enrolled 80 patients from the tertiary referral center for AIBD at the outpatient clinic or on admission to the hospital. Sixty six patients completed the 17-item questionnaires of each ABQOL and TABQOL at day 0 and after 5-7 days. Both questionnaires were translated into Polish according to protocol. The internal consistency and test-retest reliability were high (Cronbach α=0.95 for ABQOL, α=0.87 for TABQOL), (R=0.98 for ABQOL, R=0.86 for TABQOL). In convergent validity, the correlation of ABQOL and TABQOL was strong (R=0.81), but low with objective disease activity scales. The strongest impact of AIBD on QOL has been observed in flares and in patients with the onset below 70 years of age. The patients with bullous pemphigoid had the highest QOL compared to other AIBD patients. The ABQOL and TABQOL are reliable and valid instruments for the assessment of QOL in AIBD. Copyright © 2016 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.

  7. Release of fission products from miniature fuel plates at elevated temperature

    International Nuclear Information System (INIS)

    Posey, J.C.

    1982-01-01

    Three miniature fuel plates were tested at progressively higher temperatures. A U 3 Si plated blistered and released fission gases at 500 0 C. Two U 3 O 8 filled plates blistered and released fission gases at 550 0 C

  8. Deuterium retention in tungsten under combined high cycle ELM-like heat loads and steady-state plasma exposure

    Directory of Open Access Journals (Sweden)

    A. Huber

    2016-12-01

    Enhanced blister formation has been observed under combined loading conditions at power densities close to the threshold for damaging. It is shown that blisters are not mainly responsible for the pronounced increase of the D retention.

  9. Floating Carpets and the Delamination of Elastic Sheets

    KAUST Repository

    Wagner, Till J. W.; Vella, Dominic

    2011-01-01

    determine the initial blister size and the evolution of blister size with continuing compression before verifying our theoretical results with experiments at a macroscopic scale. © 2011 American Physical Society.

  10. Disease: H00693 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available osomal dominant disorder characterized by mild hyperkeratosis and blister formation. The blistering is super... to those in epidermolytic hyperkeratosis, but can be distinguished by the absenc

  11. Herpes Simplex Virus (Cold Sores)

    Science.gov (United States)

    ... Print Share Cold Sores in Children: About the Herpes Simplex Virus Page Content ​A child's toddler and ... Cold sores (also called fever blisters or oral herpes) start as small blisters that form around the ...

  12. Idelalisib

    Science.gov (United States)

    ... lips or throat; difficulty swallowing or breathing; or peeling, blistering skin, your doctor will probably tell you not to ... immediately or get emergency medical treatment: red, itching, peeling, or blistering skin painful sores or ulcers on your skin, lips, ...

  13. Genetics Home Reference: dystrophic epidermolysis bullosa

    Science.gov (United States)

    ... fragile and to blister easily. Blisters and skin erosions form in response to minor injury or friction, such as ... M, Favia G, Serpico R. Oro-dental manifestations in Hallopeau-Siemens-type recessive dystrophic epidermolysis ...

  14. Corrosion-Resistant Roof with Integrated Photovoltaic Power System

    Science.gov (United States)

    2014-02-01

    Figure 9. The panels are coated with a PVDF organic coating on the external facing surface and polyester enamel on the interior-facing surface. The high...1 no scribe No evidence of blistering, cracking , peeling or delaminating #2 scribe No evidence of blistering, cracking , peeling or delaminating...3 scribe No evidence of blistering, cracking , peeling or delaminating #4 scribe No evidence of blistering, cracking , peeling or delaminating

  15. Floating Carpets and the Delamination of Elastic Sheets

    KAUST Repository

    Wagner, Till J. W.

    2011-07-22

    We investigate the deformation of a thin elastic sheet floating on a liquid surface and subject to a uniaxial compression. We show that at a critical compression the sheet delaminates from the liquid over a finite region forming a delamination "blister." This blistering regime adds to the wrinkling and localized folding regimes that have been studied previously. The transition from wrinkled to blistered states occurs when delamination becomes energetically favorable compared with wrinkling. We determine the initial blister size and the evolution of blister size with continuing compression before verifying our theoretical results with experiments at a macroscopic scale. © 2011 American Physical Society.

  16. Surface damage of W exposed to combined stationary D plasma and ELMs-like pulsed plasma

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Y.Z., E-mail: jaja880816@aliyun.com [Science and Technology on Reactor Fuel and Materials Laboratory, Nuclear Power Institute of China, Chengdu, Sichuan 610213 (China); Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China); Liu, W., E-mail: liuw@mail.tsinghua.edu.cn [Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China); Xu, B.; Qu, S.L. [Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China); Morgan, T.W. [FOM Institute DIFFER-Dutch Institute for Fundamental Energy Research, 5612AJ Eindhoven (Netherlands)

    2017-04-15

    The surface damage of W under D plasma and ELMs-like transient heat loads was studied by combined stationary and pulsed D plasma. Low-flux transient heat loads will promote blister formation due to the gas expansion inside the blisters. On the contrary, high-flux transient heat loads will mitigate blistering due to the high surface temperature. Therefore, blistering on W surface first increased and then decreased with the increasing transient heat loads. The promotion effect of pulsed plasma on blistering is more obvious on [001] and [110] surfaces than on [111] surface, and the orientation dependence of blisters was mitigated by the transient heat loads. Surface modification induced by transient heat loads only formed on [001] and [110] surfaces, but did not form on [111] surface. The orientation dependence of surface modification was mainly due to the slipping system of dislocations.

  17. Degradation of ZrN films at high temperature under controlled atmosphere

    International Nuclear Information System (INIS)

    Lu, F.-H.; Lo, W.-Z.

    2004-01-01

    The degradation of ZrN films deposited onto Si substrates by unbalanced magnetron sputtering was investigated over temperatures of 300-1200 deg. C in different atmospheres by analyzing changes in color and appearance, as well as microstructures. The atmospheres contained air, nitrogen, and forming gas (N 2 /H 2 =9), which exhibited drastically different oxygen/nitrogen partial pressure ratios. The resultant degradation included mainly color changes and formation of blisters on the film surface. Color change was associated with the oxidation of the nitride film, which was analyzed by looking into the Gibbs free-energy changes at various temperatures and oxygen partial pressures. Two types of blisters occurred at different temperature ranges. Several large round blisters, denoted as A-type blisters, occurring at low temperatures originated from the large residual stress in the films. Many small irregular blisters, denoted as B-type blisters, appearing at relatively high temperatures resulted from the oxidation of the film

  18. Foot Marching, Load Carriage, and Injury Risk

    Science.gov (United States)

    2016-05-01

    Foot blisters: Though not a musculoskeletal injury , past studies and reviews have described foot blisters as one of the most common marching... injuries were the highest among all activities in these studies, ranging from 36 to 69 limited duty days per injury .23, 24 The top three most common ...Knapik, and J.J. 1994. Exercise, training and injuries . Sports Med 18(3): 202-1. 35. APHC (Prov) Blister Prevention Factsheet. 2015. Available at

  19. Erosion of the first wall of Tokamaks

    International Nuclear Information System (INIS)

    Guseva, M.I.; Ionova, E.S.; Martynenko, Yu.V.

    1980-01-01

    An estimate of the rate of erosion of the wall due to sputtering and blistering requires knowledge of the fluxes and energies of the particles which go from the plasma to the wall, of the sputtering coefficients S, and of the erosion coefficients S* for blistering. The overall erosion coefficient is equal to the sum of the sputtering coefficient and the erosion coefficient for blistering. Here the T-20 Tokamak is examined as an example of a large-scale Tokamak. 18 refs

  20. Apparatus Tests Peeling Of Bonded Rubbery Material

    Science.gov (United States)

    Crook, Russell A.; Graham, Robert

    1996-01-01

    Instrumented hydraulic constrained blister-peel apparatus obtains data on degree of bonding between specimen of rubbery material and rigid plate. Growth of blister tracked by video camera, digital clock, pressure transducer, and piston-displacement sensor. Cylinder pressure controlled by hydraulic actuator system. Linear variable-differential transformer (LVDT) and float provide second, independent measure of change in blister volume used as more precise volume feedback in low-growth-rate test.

  1. 78 FR 45911 - Foreign-Trade Zone (FTZ) 38-Spartanburg County, South Carolina, Notification of Proposed...

    Science.gov (United States)

    2013-07-30

    ... labels; blister cards; advertising flyers; leaflets; bulletins; warranty cards; survey cards; slot liners...; solders; solder wire; prepared solder bars; parts of inflator fans; mobile bases; wheels for lawnmowers...

  2. Release of fission products from miniature fuel plates at elevated temperature

    International Nuclear Information System (INIS)

    Posey, John C.

    1983-01-01

    Three miniature fuel plates were tested at progressively higher temperatures. A U 3 Si filled plate blistered and released fission gases at 500 deg. C. Two U 3 O 8 filled plates blistered and released fission gases at 550 deg. C. (author)

  3. Pre and post garter spring repositioning ultrasonic inspection of pressure tubes

    International Nuclear Information System (INIS)

    Desimone, C.; Katchadjian, P.; Tacchia, Mauricio

    1997-01-01

    This paper present a description of the ultrasonic cracked hydride blister detections system used for pre and post inspection of pressure tubes during garter spring repositioning in CNE (Embalse Nuclear Power Station). Ultrasonic system setup configuration, transducers characteristics, blister detection head, calibration of parameters, operating procedure, records of ultrasonic inspections and evaluation. (author) [es

  4. Chickenpox

    Science.gov (United States)

    ... a person's ears and mouth. The number of pox is different for everyone. Some people get just a few bumps; others are covered from head to toe. At first, the rash looks like pinkish dots that quickly develop a small blister on top (a blister is a bump ...

  5. Surface damage of 316 stainless steel irradiated with 4He+ to high doses

    International Nuclear Information System (INIS)

    Kaminsky, M.; Das, S.K.

    1978-01-01

    Surface blistering of niobium by implantation with helium ions in the 9 to 15 keV range was investigated. The apparent disappearance of blisters at sufficiently high doses was believed to be an equilibrium effect. To determine whether high temperature annealing causes the equilibrium condition, stainless steel-316 samples were irradiated at a constant 450 0 C. Results are presented

  6. Unusual presentation of childhood Systemic Lupus Erythematosus

    Science.gov (United States)

    Kumar, Sathish; Agarwal, Indira

    2007-01-01

    Bullous systemic lupus erythematosus is a rare blistering condition with a distinctive combination of clinical, histological and immunopathologic features that together constitute a unique bullous disease phenotype. It is often associated with autoimmunity to type VII collagen. Here we report a child who presented with bullous systemic lupus erythematosus. Rapid resolution of the blisters occurred following treatment with dapsone. PMID:18028550

  7. "I've got a UFO stuck in my throat!"--an interesting case of foreign body impaction in the oesophagus.

    Science.gov (United States)

    Yip, L W; Goh, F S; Sim, R S

    1998-03-01

    This is a case report of an elderly lady with odynophagia because she accidentally swallowed a tablet which was still wrapped in its blister pack. A discussion of foreign body ingestion, particularly in the elderly, is included. To the authors' knowledge, this is the first paper that includes a lateral cervical radiograph of an ingested blister pack.

  8. Increased Levels of Type I and III Collagen and Hyaluronan in Scleroderma Skin

    DEFF Research Database (Denmark)

    Søndergaard, Klaus; Heickendorff, Lene; L, Risteli

    1997-01-01

    The aminoterminal propeptide of type III procollagen (PIIINP) and the carboxyterminal propeptide of type I procollagen (PICP) and hyaluronan (HA) were measured in plasma and suction blister fluid from 13 systemic sclerosis patients and 11 healthy volunteers. Suction blisters and skin biopsies were...

  9. Surface damage of TFTR protective plate candidate materials by energetic D+ irradiation

    International Nuclear Information System (INIS)

    Kaminsky, M.; Das, S.K.

    1979-01-01

    Experiments were conducted to determine the surface damage of ATJ graphite, V, Cu, and Type 316 stainless steel under 60-keV D + irradiation. The irradiations were conducted in the pulsed mode. For a total accumulated dose of 8.1 x 10 18 ions/cm 2 , blisters were readily seen for Cu surfaces, but no blisters were observed on Type 316 stainless steel and vanadium surfaces. For the case of ATJ graphite, the surface damage was observed in the form of ridges and grooves. In the case of copper, many large blisters with diameters ranging from 3.5 μm to 46 μm are observed in addition to some small ones (average diameter approx. 2 μm. The blister density of the large blisters is the highest in the case of copper (1.1 x 10 5 blisters/cm 2 ). These observations of blister formation are related to the differences in the premeability of deuterium in these materials. An examination of the cross section of the ridges in fractured samples of graphite indicates that they are not hollow. The mechanisms of formation of these ridges is not clear at present. 1 figure

  10. Measuring Patient Adherence to Malaria Treatment: A Comparison of Results from Self-Report and a Customised Electronic Monitoring Device.

    Science.gov (United States)

    Bruxvoort, Katia; Festo, Charles; Cairns, Matthew; Kalolella, Admirabilis; Mayaya, Frank; Kachur, S Patrick; Schellenberg, David; Goodman, Catherine

    2015-01-01

    Self-report is the most common and feasible method for assessing patient adherence to medication, but can be prone to recall bias and social desirability bias. Most studies assessing adherence to artemisinin-based combination therapies (ACTs) have relied on self-report. In this study, we use a novel customised electronic monitoring device--termed smart blister packs--to examine the validity of self-reported adherence to artemether-lumefantrine (AL) in southern Tanzania. Smart blister packs were designed to look identical to locally available AL blister packs and to record the date and time each tablet was removed from packaging. Patients obtaining AL at randomly selected health facilities and drug stores were followed up at home three days later and interviewed about each dose of AL taken. Blister packs were requested for pill count and extraction of smart blister pack data. Data on adherence from both self-report verified by pill count and smart blister packs were available for 696 of 1,204 patients. There was no difference between methods in the proportion of patients assessed to have completed treatment (64% and 67%, respectively). However, the percentage taking the correct number of pills for each dose at the correct times (timely completion) was higher by self-report than smart blister packs (37% vs. 24%; psmart blister packs, 64% of patients completing treatment did not take the correct number of pills per dose or did not take each dose at the correct time interval. Smart blister packs resulted in lower estimates of timely completion of AL and may be less prone to recall and social desirability bias. They may be useful when data on patterns of adherence are desirable to evaluate treatment outcomes. Improved methods of collecting self-reported data are needed to minimise bias and maximise comparability between studies.

  11. Measuring Patient Adherence to Malaria Treatment: A Comparison of Results from Self-Report and a Customised Electronic Monitoring Device.

    Directory of Open Access Journals (Sweden)

    Katia Bruxvoort

    Full Text Available Self-report is the most common and feasible method for assessing patient adherence to medication, but can be prone to recall bias and social desirability bias. Most studies assessing adherence to artemisinin-based combination therapies (ACTs have relied on self-report. In this study, we use a novel customised electronic monitoring device--termed smart blister packs--to examine the validity of self-reported adherence to artemether-lumefantrine (AL in southern Tanzania.Smart blister packs were designed to look identical to locally available AL blister packs and to record the date and time each tablet was removed from packaging. Patients obtaining AL at randomly selected health facilities and drug stores were followed up at home three days later and interviewed about each dose of AL taken. Blister packs were requested for pill count and extraction of smart blister pack data.Data on adherence from both self-report verified by pill count and smart blister packs were available for 696 of 1,204 patients. There was no difference between methods in the proportion of patients assessed to have completed treatment (64% and 67%, respectively. However, the percentage taking the correct number of pills for each dose at the correct times (timely completion was higher by self-report than smart blister packs (37% vs. 24%; p<0.0001. By smart blister packs, 64% of patients completing treatment did not take the correct number of pills per dose or did not take each dose at the correct time interval.Smart blister packs resulted in lower estimates of timely completion of AL and may be less prone to recall and social desirability bias. They may be useful when data on patterns of adherence are desirable to evaluate treatment outcomes. Improved methods of collecting self-reported data are needed to minimise bias and maximise comparability between studies.

  12. Nitrous oxide for procedural analgesia at home in a child with epidermolysis bullosa.

    Science.gov (United States)

    Ingelmo, Pablo; Wei, Andrew; Rivera, Gonzalo

    2017-07-01

    Epidermolysis bullosa comprises a range of conditions characterized by fragile skin with painful blistering induced by minor trauma and friction. The Dowling-Meara variant is a severe form characterized by disseminated painful blistering requiring lifelong skin and wound care. The natural history of the disease is characterized by a chronic course that tends to improve with advancing age. Various multimodal analgesic strategies have been proposed for painful procedures in children with epidermolysis bullosa. In this case report, we describe the use of nitrous oxide for pain control at home of blister treatments in a 4-year-old child with the Dowling-Meara variant. © 2017 John Wiley & Sons Ltd.

  13. Soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptors (sIL-2R) in scleroderma skin

    DEFF Research Database (Denmark)

    Søndergaard, Klaus; Deleuran, Mette; Heickendorff, Lene

    1998-01-01

    In order to investigate whether soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptors (sIL-2R) were present in scleroderma skin, and to compare their levels to concentrations measured in plasma and clinical parameters, we examined suction blister fluid and plasma...... from 13 patients with systemic sclerosis and 11 healthy volunteers. Suction blisters and biopsies were from the transition zone between normal skin and scleroderma, and uninvolved abdominal skin. The levels of sICAM-1 and sIL-2R were significantly increased in both plasma and suction blister fluid from...

  14. Lionfish envenomation of the hand.

    Science.gov (United States)

    Patel, M R; Wells, S

    1993-05-01

    Lionfish (Pterois volitans) envenomation of the hand causes excruciating pain and occurs in three grades: (1) erythematous reaction, (2) blister formation, and (3) dermal necrosis. The initial treatment in all cases is to soak the hand in nonscalding water (45 degrees C) until the pain subsides by denaturing the thermolabile venom proteins. The blisters should be immediately excised to prevent dermal necrosis, inasmuch as the blister fluid contains residual active venom. To prevent a hypersensitivity reaction, any further contact with the fish should be avoided.

  15. Disease: H00585 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available lysis bullosa simplex, Ogna type (EBS-Ogna) Inherited epidermolysis bullosa is a diverse group of disorders characterized by mechanic...ally fragile skin that readily blister. The conditions i

  16. Disease: H00586 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available osa, junctional, with pyloric atresia (JEB-PA) Inherited epidermolysis bullosa is a diverse group of disorders characterized by mecha...nically fragile skin that readily blister. The junctiona

  17. Skin Complications

    Science.gov (United States)

    ... Text Size: A A A Listen En Español Skin Complications Diabetes can affect every part of the ... lipoidica diabeticorum, diabetic blisters, and eruptive xanthomatosis. General Skin Conditions Bacterial Infections Several kinds of bacterial infections ...

  18. Thermal Degradation Study of IM7/DMBZ-15 High Temperature Composite by TGA/FTIR

    National Research Council Canada - National Science Library

    Nadler, Melvin

    2003-01-01

    (U) High temperature graphite composites such as IM7/8552 epoxy, IM7/5250 BMI, and IM7/DMBZ-15 polyimide show blistering and/or "catastrophic" delamination when rapidly heated to temperatures above...

  19. Bug bites and stings: When to see a dermatologist

    Medline Plus

    Full Text Available ... hair, and nail care Skin care Hair care / hair loss Injured skin Nail care Anti-aging skin care ... hair, and nail care Skin care Hair care / hair loss Injured skin Blisters Bug bites and stings How ...

  20. Proposal for a Coordinated Research Project: Prediction of Axial and Radial Creep in Pressure Tubes

    International Nuclear Information System (INIS)

    Bozzano, Patricia B.

    2013-01-01

    Participation of Argentina: • hydrogen charge of 90 samples for hydrogen determination: IGF, HVEMS, DSC, Resistivity, DTA; • 17 samples for non destructive techniques; • 6 blisters in CANDU pressure tube sections for NDT evaluation

  1. Mouth Problems and HIV

    Science.gov (United States)

    ... teeth (periodontitis), canker sores, oral warts, fever blisters, oral candidiasis (thrush), hairy leukoplakia (which causes a rough, white patch on the tongue), and dental caries. Read More Publications Cover image Mouth Problems + HIV Publication files Download Language English PDF — ...

  2. 78 FR 15681 - Beaverhead-Deerlodge National Forest, Dillon Ranger District; Montana; Birch, Willow, Lost Project

    Science.gov (United States)

    2013-03-12

    ... higher susceptibility to insect and disease such as mountain pine beetle and blister rust. Responsible... documentation. Dated: March 5, 2013. Cole Mayn, Acting Dillon District Ranger. [FR Doc. 2013-05574 Filed 3-11-13...

  3. Bioterrorism

    Science.gov (United States)

    ... Blisters may form, followed by a deep, black scab. The area is usually painless. Gastrointestinal anthrax typically ... agents have also been studied for use as biological weapons, such as tularemia, brucellosis, Q fever, and ...

  4. Chickenpox

    Science.gov (United States)

    ... coughing and sneezing) and by direct contact with mucus, saliva (spit), or fluid from the blisters. Chickenpox ... to the baby through the placenta and breast milk. How Is Chickenpox Diagnosed? Doctors usually can diagnose ...

  5. Celiac Disease: Symptoms, Diagnosis & Treatment

    Science.gov (United States)

    ... Table of Contents What are some of the symptoms of celiac disease? Some people with celiac disease may not feel ... skin rash with blisters slowed growth Why are celiac disease symptoms so varied? Researchers are studying the reasons celiac ...

  6. Stevens-Johnson Syndrome

    Science.gov (United States)

    ... after blisters form If you have Stevens-Johnson syndrome, several days before the rash develops you may experience: Fever Sore mouth and throat Fatigue Cough Burning eyes When to see a doctor Stevens-Johnson ...

  7. Partial genome sequence of currant latent virus, a new chera-like virus related to Apple latent spherical virus

    Czech Academy of Sciences Publication Activity Database

    Petrzik, Karel; Přibylová, Jaroslava; Špak, Josef; Havelka, Jan

    2015-01-01

    Roč. 81, č. 2 (2015), s. 142-145 ISSN 1345-2630 Institutional support: RVO:60077344 Keywords : Picornaviridae * Red currant blister aphid * Ribes Subject RIV: EE - Microbiology, Virology Impact factor: 1.120, year: 2015

  8. Helium trapping in aluminum and sintered aluminum powders

    International Nuclear Information System (INIS)

    Das, S.K.; Kaminsky, M.; Rossing, T.

    1975-01-01

    The surface erosion of annealed aluminum and of sintered aluminum powder (SAP) due to blistering from implantation of 100-keV 4 He + ions at room temperature has been investigated. A substantial reduction in the blistering erosion rate in SAP was observed from that in pure annealed aluminum. In order to determine whether the observed reduction in blistering is due to enhanced helium trapping or due to helium released, the implanted helium profiles in annealed aluminum and in SAP have been studied by Rutherford backscattering. The results show that more helium is trapped in SAP than in aluminum for identical irradiation conditions. The observed reduction in erosion from helium blistering in SAP is more likely due to the dispersion of trapped helium at the large Al-Al 2 O 3 interfaces and at the large grain boundaries in SAP than to helium release

  9. Skin disorders affecting the feet

    African Journals Online (AJOL)

    blistering, with weeping lesions, leading to secondary bacterial infection. ... 2015; 57(4):34-38. Open Access article distributed under the terms of the .... appear as bluish macules and plaques. Late lesions ... Oxford: Blackwell Science,1998; p.

  10. Gefitinib

    Science.gov (United States)

    ... of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance ... blisters or peeling skin swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles or ...

  11. Erlotinib

    Science.gov (United States)

    ... of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals ... acne and may affect the skin on the face, upper chest, or back) blistering, peeling, dry, or ...

  12. Ruxolitinib

    Science.gov (United States)

    ... of medications called kinase inhibitors. It works by blocking an enzyme that causes scar tissue to form ... sensitivity on one side of the body or face with painful rash or blisters appearing several days ...

  13. Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test

    NARCIS (Netherlands)

    Kardaun, Sylvia H.; de Monchy, Jan G.

    Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed. Best known are Urticaria, erythema, and pruritus; sometimes pseudoallergic anaphylactoid reactions, and blisters are reported.

  14. Canker sore

    Science.gov (United States)

    ... under one third inch or 1 centimeter across) Gray color as healing starts Less common symptoms include: ... Aphthous ulcer; Ulcer - aphthous Images Canker sore Mouth anatomy Canker sore (aphthous ulcer) Fever blister References Bope ...

  15. Genital sores - male

    Science.gov (United States)

    Sores - male genitals; Ulcers - male genitals ... A common cause of male genital sores are infections that are spread through sexual contact, such as: Genital herpes (small, painful blisters filled with clear ...

  16. Pachyonychia Congenita

    Science.gov (United States)

    ... Bullosa Lichen Sclerosus Pachyonychia Congenita Pemphigus Psoriasis Raynaud’s Phenomenon Rosacea Vitiligo All Diseases and Conditions Kids Pages ... on the soles of the feet when a child begins to walk. In some cases, blisters and ...

  17. Junctional epidermolysis bullosa(non-herlitz type)

    International Nuclear Information System (INIS)

    Bhinder, M. A.; Arshad, M. W.; Shabbir, M. I.; Zahoor, M. Y.; Shehzad, W.; Tariq, M.

    2017-01-01

    Junctional epidermolysis bullosa (JEB) is a recessively inherited skin blistering disease and is caused due to abnormalities in proteins that hold layers of the skin. Herlitz JEB is the severe form and non-Herlitz JEB is the milder form. This report describes a case of congenitally affected male child aged 5 years, with skin blistering. He has mitten-like hands and soft skin blistering on hands, legs and knees. Symptoms almost disappeared at the age of 3 years but reappeared with increased severity after 6 months. Histopathological examination showed epidermal detachment with intact basal cell layer and sparse infiltrate of lymphocytes with few eosinophils in the dermis. There was no blistering on the moist lining of the mouth and digestive tract. Localized symptoms with less lethality and histopathological examination indicated the presence of non-Herlitz type of JEB. This is the first report which confirms the presence of non-Herlitz junctional epidermolysis bullosa in Pakistan. (author)

  18. Junctional Epidermolysis Bullosa (Non-Herlitz Type).

    Science.gov (United States)

    Bhinder, Munir Ahmad; Arshad, Muhammad Waqar; Zahoor, Muhammad Yasir; Shehzad, Wasim; Tariq, Muhammad; Shabbir, Muhammad Imran

    2017-05-01

    Junctional epidermolysis bullosa (JEB) is a recessively inherited skin blistering disease and is caused due to abnormalities in proteins that hold layers of the skin. Herlitz JEB is the severe form and non-Herlitz JEB is the milder form. This report describes a case of congenitally affected male child aged 5 years, with skin blistering. He has mitten-like hands and soft skin blistering on hands, legs and knees. Symptoms almost disappeared at the age of 3 years but reappeared with increased severity after 6 months. Histopathological examination showed epidermal detachment with intact basal cell layer and sparse infiltrate of lymphocytes with few eosinophils in the dermis. There was no blistering on the moist lining of the mouth and digestive tract. Localized symptoms with less lethality and histopathological examination indicated the presence of non-Herlitz type of JEB. This is the first report which confirms the presence of non-Herlitz junctional epidermolysis bullosa in Pakistan.

  19. EPA Science Matters Newsletter: Chemical Warfare Agent Analytical Standards Facilitate Lab Testing (Published November 2013)

    Science.gov (United States)

    Learn about the EPA chemists' efforts to develop methods for detecting extremely low concentrations of nerve agents, such as sarin, VX, soman and cyclohexyl sarin, and the blister agent sulfur mustard.

  20. to view fulltext PDF

    Indian Academy of Sciences (India)

    blisters and lays its hands on corpses. ... experimental, quantitative and theoretical understandings enable us to acquire .... experiments to weigh this fluid. ... of the close relationships between the mechanical energy of atoms and molecules.

  1. Spider Bites (For Parents)

    Science.gov (United States)

    ... Videos for Educators Search English Español First Aid: Spider Bites KidsHealth / For Parents / First Aid: Spider Bites ... rare. Signs and Symptoms Of a brown recluse spider bite: red blister in the center with surrounding ...

  2. Carriers with functional null mutations in LAMA3 have localized enamel abnormalities due to haploinsufficiency

    NARCIS (Netherlands)

    Gostynska, Katarzyna B.; Yuen, Wing Yan; Pasmooij, Anna Maria Gerdina; Stellingsma, Cornelius; Pas, Hendri H.; Lemmink, Henny; Jonkman, Marcel F.

    2017-01-01

    The hereditary blistering disease junctional epidermolysis bullosa (JEB) is always accompanied by structural enamel abnormalities of primary and secondary dentition, characterized as amelogenesis imperfecta. Autosomal recessive mutations in LAMA3, LAMB3 and LAMC2 encoding the heterotrimer laminin

  3. Isotretinoin

    Science.gov (United States)

    ... mouth, or nose nosebleeds changes in skin color peeling skin on the palms of the hands and soles ... red, swollen, itchy, or teary eyes fever rash peeling or blistering skin, especially on the legs, arms, or face sores ...

  4. Ideal Internal Carotid Artery Trapping Technique without Bypass in a Patient with Insufficient Collateral Flow

    OpenAIRE

    Chung, Joon Ho; Shin, Yong Sam; Lim, Yong Cheol; Park, Minjung

    2009-01-01

    Internal carotid artery (ICA) trapping can be used for treating intracranial giant aneurysm, blood blister-like aneurysms and ICA rupture during the surgery. We present a novel ICA trapping technique which can be used with insufficient collaterals flow via anterior communicating artery (AcoA) and posterior communicating artery (PcoA). A patient was admitted with severe headache and the cerebral angiography demonstrated a typical blood blister-like aneurysm at the contralateral side of PcoA. F...

  5. The Effect of Substrate Contaminates on the Life of Epoxy Coatings Submerged in Sea Water

    Science.gov (United States)

    1991-03-01

    contaminants: coal tar, SovaPon, Mare Island and Aquapon . Aquapon is a clear (unpigmented) polyamide epoxy coating. While Aquapon is not normally used for...pigmented coatings. It was found that the Aquapon and coal tar coatings performed similarly, and blistered to the same extent, at the contamination levels...used in the test program. The Sovapon and Mare Island coatings were slightly more resistive to blistering when compared to Aquapon or coal tar but they

  6. Gunther′s Disease

    Directory of Open Access Journals (Sweden)

    Gupta Somesh

    1998-01-01

    Full Text Available A three year old female child of Gunther’s disease with blistering over exposed parts of body, mutilation of nose and fingers, scanning alopecia and erythrodontia, is reported. Her urine was strongly positive for uropoprhyrinogen. The blistering could not be prevented by strict avoidance of sun, sunscreen with high SPF, chloroquine, high doses of activated charcoal and betacarotene, though there was significant symptomatic improvement by repeated packed erythrocyte transfusion.

  7. Facies of ion bombarded surfaces of brittle materials

    International Nuclear Information System (INIS)

    Primak, W.

    1975-12-01

    Materials were bombarded by protons, deuterons, and helium ions. The materials investigated were quartz; glasses; carbides and borides (SiC, B 4 C, TiB 2 ); oxides and nitrides (magnorite, sapphire, spinel, Al 2 O 3 , Si 3 N 4 , ZrO 2 , BaTiO 3 ); and miscellaneous (graphite, LiNbO 3 , copper). Oberservations were of growth, reflectivity, blistering, surface ablation, and swelling. Calculations were made of the effects of a layer, of its gradual transformation, and of the introduction of a gas. It is concluded that: Radiation blistering is not a primary process. Observations of blister formation and exfoliation cannot be used to calculate the surface ablation rate. The primary process is the development of a microporous layer which causes swelling. Visible blisters are caused by fracturing by transverse stresses in this layer and may occur during the bombardment, or in some cases, much later, in storage. There is no evidence of extreme gas pressures in the blisters. When blisters develop, they may be stable under continued bombardment for a dose many times that at which they formed. The swelling is a better index of the effects than is the blistering, and must be associated in most cases with permeability to the gas. Behavior with protons and deuterons is similar, with helium different. All but quartz, vitreous silica, and Pyrex are impervious to hydrogen and deuterium; only dense barium crown glass, carbides, borides, oxides, and nitrides are impervious to helium. Quartz shows swelling caused by conversion to a vitreous product of much lower density but no porosity, while for the others, most of the swelling and surface growth is caused by porosity. Surface ablation by the blistering process may be reduced by initial porosity or by initial or subsequent surface fissuring. However, for impervious materials, surface damage by the introduction of porosity would continue

  8. Development of a Computerized Data Base to Monitor Wheeled Vehicle Corrosion

    Science.gov (United States)

    1989-10-01

    Outside Storage of Cardboard Containers and Wood Crates .... ............ .77 5.9-7. Outside Storage of Large Components ... ........ 78 5.9-8. Indoor...for data collection: GR General Rusting GP General Pitting GPB General Paint Blistering GW General Wear LP Local Pitting LCA Local Chemical Attack LCC...upon surface area exposure of base metal. Therefore, when up to 1/5 of the surface area of the part has had the paint blistered, chipped , spalled, or

  9. Silvical characteristics of balsam fir (Abies balsamea)

    Science.gov (United States)

    Arthur C. Hart

    1959-01-01

    Balsam fir takes its name from the Latin word for balm. Some people know the tree as the Balm-of-Gilead fir. It has also been called the blister fir, because of the bark blisters that yield Canada balsam, a resin that is used for, among other things, mounting microscope slides. The needles of balsam fir have a spicy aroma that Donald Culross Peattie has called "...

  10. Coexisting Morphea and Bullous Lichen Sclerosus Et Atrophicus: A Case Report

    OpenAIRE

    Nurcan Metin; Mahizer Yaldız; Teoman Erdem; Şahin Erdem

    2015-01-01

    Morphea and lichen skleroatrofikans (LSA)are localized fibrosing diseases characterized by well-defined fibrotic plaques. Blisters rarely occur on morphea plaque, and these blisters are mostly considered as bullous morphea which is a rare type of morphea. The cases of bullous LSA growing on plaque morphea are rarer. In this case report, we presented a patient has bullous lesions compatible with of lichen skleroatrofikans clinically and histopathologically on morphea lesions, to draw attention...

  11. Acral peeling skin syndrome: a case of two brothers.

    Science.gov (United States)

    Wakade, Oojwala; Adams, Beth; Shwayder, Tor

    2009-01-01

    We report two brothers of Middle Eastern descent with consanguineous parents who present with numerous fragile, flaccid blisters on the hands and feet. In addition to spontaneous peeling, they can manually peel skin from acral areas without pain. The symptoms worsen with warm temperatures, excessive water exposure, and perspiration. Two biopsies from flaccid blisters on the feet were taken from the older brother, which revealed cleavage at the level of the stratum corneum. A diagnosis of acral peeling skin syndrome was made.

  12. Damage of niobium surfaces caused by bombardment with 4He+ ions of different energies typical for T-20

    International Nuclear Information System (INIS)

    Guseva, M.I.; Gusev, V.; Martynenko, Yu.V.; Das, S.K.; Kaminsky, M.

    1979-01-01

    The aim of the present studies was to study surface damage due to blistering of both annealed and cold-worked niobium (a candidate first wall material for keV) irradiated sequentially with 4 He + ions with energies of 0.5 to 1800 keV for a total dose of 5.0 C/cm 2 . A typical surface of cold-worked Nb after irradiations with 4 He + ions with increasing energy from 0.5 to 90 keV is shown. The blister diameters range from 0.1 μm to 3 μm, and most of the blisters have exfoliated. The blisters fall into several size classes, the two most dominant ones having most probable blister diameters of approx. 0.27 μm and approx. 2.0 μm. The skin thickness of the larger blisters was measured to be approx. 0.23 μm. Also shown is the same area after irradiation with 150-1800-keV 4 He + irradiation for a dose of 0.66 C/cm 2 . A few additional blisters can be seen. A cold-worked Nb surface that was irradiated only with 150-1800-keV 4 He + ions is also shown. It is seen that prior irradiation with 0.5-90-keV 4 He + helped in significantly reducing blistering. For a total dose of 0.5 C/cm 2 , the erosion yield due to helium blistering of Nb ranges from (5.4 +- 2.0) x 10 -3 to (1.5 +- 0.7) x 10 -2 atoms/ion. For the cold-worked Nb target the results indicate clearly that the 4 He + implantations for the energy range from 0.5 to 90 keV help to reduce both the density and diameter of blisters formed by subsequent He-implantation for the energy ranging from 150 to 1800 keV. 2 figures

  13. Ion irradiation and thermal cycling tests of TiC coatings

    International Nuclear Information System (INIS)

    Yamanaka, S.; Ohara, H.; Son, P.; Miyake, M.

    1984-01-01

    Ion irradiation of TiC coatings prepared by diffusion annealing was performed with 20-40 keV He + ions for different doses at room temperature. The polished TiCsub(0.99) coatings irradiated with 40 keV He + ions showed the surface damage and erosion due to blistering and exfoliation above a dose of 1.8x10 17 ions/cm 2 , whereas no change in the surface morphology could be detected for the as-prepared coatings up to a dose of 1.4x10 18 ions/cm 2 . The results suggested that surface erosion due to blistering can be effectively reduced on the rough surface of the as-prepared TiC coating. The average blister diameter in the polished TiCsub(0.99) coating increased with increasing projectile energy. For the 40 keV He + ion irradiation of the polished TiCsub(0.5) coatings, general features in blisters were similar to those observed for the TiCsub(0.99) coatings, but the critical dose for blistering shifted to a higher value in comparison with the polished TiCsub(0.99) coating. Thermal cycling between 500 and 1200 0 C caused serious surface damage for the TiCsub(0.99) coating irradiated with 40 keV He + ions below the critical dose for blistering, while the coating with surface damage due to blistering showed no significant change in the surface topography after thermal cycling. (orig.)

  14. Effects of temperature on surface modification of W exposed to He particles

    International Nuclear Information System (INIS)

    Li, C.; Greuner, H.; Yuan, Y.; Luo, G.N.; Böswirth, B.; Fu, B.Q.; Xu, H.Y.; Jia, Y.Z.; Liu, W.

    2014-01-01

    Highlights: • Blisters were observed on W surface under He beam heating at ∼950 °C. • He-induced blistering shows a clear grain orientation dependence. • An evolution to a coral-like structure was observed under loading at ∼2700 °C. • A texture with 〈0 0 1〉 parallel to the surface normal direction will be beneficial. - Abstract: The effect of combined heating and helium particle flux on annealed tungsten samples has been studied in the neutral beam facility GLADIS. He beams with power densities of 2.4 MW/m 2 and 9.5 MW/m 2 were used to adiabatically load the samples to peak surface temperatures from ∼950 °C (1223 K) to ∼2700 °C (2973 K). Changes in the surface morphology resulting from combined heat and the flux exposure were studied for He fluences up to 3 × 10 22 /m 2 . Typical structures for the sample loaded at ∼950 °C (1223 K) were blisters with a clear grain orientation dependence and the largest blisters formed on grains with 〈0 0 1〉 surface normal. However at higher temperatures, blistering was more easily suppressed for grains near this orientation because the growth of larger blister takes place more slowly. An evolution from a “porous structure” to a “coral-like structure” with increasing fluence was observed on the samples loaded at the highest temperature. Based on these results mechanisms for surface modification at different temperatures are discussed and a texture with 〈0 0 1〉 parallel to the normal direction of the grains is suggested to optimize the plasma facing material due to their stronger resistance to early stage blistering

  15. Autoimmune Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis, and Management.

    Science.gov (United States)

    Amber, Kyle T; Murrell, Dedee F; Schmidt, Enno; Joly, Pascal; Borradori, Luca

    2018-02-01

    Autoimmune subepidermal blistering diseases of the skin and mucosae constitute a large group of sometimes devastating diseases, encompassing bullous pemphigoid, gestational pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, and anti-p200 pemphigoid. Their clinical presentation is polymorphic. These autoimmune blistering diseases are associated with autoantibodies that target distinct components of the basement membrane zone of stratified epithelia. These autoantigens represent structural proteins important for maintenance of dermo-epidermal integrity. Bullous pemphigoid (BP) is the most common subepidermal autoimmune blistering disease of the skin and mucosae. Although the disease typically presents with a generalized blistering eruption associated with itch, atypical variants with either localized bullous lesions or "non-bullous" presentations are observed in approximately 20% of patients. A peculiar form of BP typically associated with pregnancy is pemphigoid gestationis. In anti-p200 pemphigoid, patients present with tense blisters on erythematosus or normal skin resembling BP, with a predilection for acral surfaces. These patients have antibodies targeting the 200-kDa basement membrane protein. Epidermolysis bullosa is a rare autoimmune blistering disease associated with autoantibodies against type VII collagen that can have several phenotypes including a classical form mimicking dystrophic epidermolysis bullosa, an inflammatory presentation mimicking BP, or mucous membrane pemphigoid-like lesions. Mucous membrane pemphigoid (MMP) is the term agreed upon by international consensus for an autoimmune blistering disorder, which affects one or more mucous membrane and may involve the skin. The condition involves a number of different autoantigens in the basement membrane zone. It may result in severe complications from scarring, such as blindness and strictures. Diagnosis of these diseases relies on direct immunofluorescence microscopy studies

  16. Problems experienced by older people when opening medicine packaging.

    Science.gov (United States)

    Philbert, Daphne; Notenboom, Kim; Bouvy, Marcel L; van Geffen, Erica C G

    2014-06-01

    Medicine packages can cause problems in daily practice, especially among older people. This study aimed to investigate the prevalence of problems experienced by older people when opening medicine packaging and to investigate how patients manage these problems. A convenience sample of 30 community pharmacies participated in this study. They selected a systematic sample of 30 patients over 65 years old with a recent omeprazole prescription, and a questionnaire was administered by telephone for at least 10 patients per pharmacy. A total of 317 patients completed the questionnaire. They received their omeprazole in a bottle (n = 179, 56.5%), push-through blister pack (n = 102, 32.2%) or peel-off blister pack (n = 36, 11.4%). Some 28.4% of all patients experienced one or more problems with opening their omeprazole packaging; most problems occurred with peel-off blisters (n = 24, 66.7% of all respondents using peel-off blisters), followed by push-through blisters (n = 34, 33.3%) and finally bottles (n = 32, 17.9%). The risk of experiencing problems with peel-off blisters and push-through blisters was higher [relative risk 3.7 (95% confidence interval 2.5-5.5) and 1.9 (1.2-2.8), respectively] than the risk of experiencing problems with opening bottles. Two-thirds of respondents reported management strategies for their problems. Most were found for problems opening bottles (n = 24, 75%), followed by push-through blisters (n = 24, 70.6%) and peel-off blisters (n = 14, 58.3%). One in four patients over 65 experienced difficulties opening their omeprazole packaging and not all of them reported a management strategy for their problems. Manufacturers are advised to pay more attention to the user-friendliness of product packaging. In addition, it is important that pharmacy staff clearly instruct patients on how to open their medicine packaging, or assist them in choosing the most appropriate packaging. © 2013 Royal Pharmaceutical Society.

  17. Surface deformation effects on stainless steel, Ni, Cu and Mo produced by medium energy He ions irradiation

    International Nuclear Information System (INIS)

    Constantinescu, B.; Florescu, V.; Sarbu, C.

    1993-01-01

    To investigate dose and energy dependence of surface deformation effects (blistering and flaking), different kinds of candidate CTR first wall materials as 12KH18N10T, W-4541, W-4016 and SS-304 stainless steels, Ni, Cu, Mo were irradiated at room temperature with 3.0, 4.7 and 6.8 MeV He + ions at IAP Cyclotron. The effects were investigated by means of a TEMSCAN 200 CX electron microscope and two metallographic Orthoplan Pol Leitz and Olympus microscopes. We observed two dose dependent main phenomena: blistering and flaking (craters). So, blisters occurrence on the irradiated surface is almost instantaneous when a critical dose (number of He ions accumulated in the region at the end of alpha particles range) is reached. Increasing irradiation dose, we reached flaking stage. So, isolated submicronic fissures along grain boundaries were observed on the blister skin, chronologically followed by large (5-20 μm) deep cracks of hundreds of microns in length, blisters opening and, finally, flaking appearance. (author) 8 figs., 1 tab

  18. Oral Manifestations and Dental Management of Epidermolysis Bullosa Simplex.

    Science.gov (United States)

    Scheidt, Lisa; Sanabe, Mariane Emi; Diniz, Michele Baffi

    2015-01-01

    Epidermolysis bullosa (EB) is a group of hereditary chronic disorders, characterized by fragility of the skin and mucous membranes in response to minor mechanical trauma. The objective of this study was to report the case of a young girl diagnosed with epidermolysis bullosa simplex (EBS), transmitted by an autosomal dominant gene. Cutaneous findings included blisters and dystrophy following minimal friction. Recurrent blisters and vesicle formation on the hard palate were the main oral findings. In conclusion, publications concerning the oral and clinical manifestations of EBS are important for providing knowledge and an early multidisciplinary approach that prevents blister formation and improves these patients' quality of life, with the dentist playing an important role in oral health management. How to cite this article: Scheidt L, Sanabe ME, Diniz MB. Oral Manifestations and Dental Management of Epidermolysis Bullosa Simplex. Int J Clin Pediatr Dent 2015;8(3):239-241.

  19. Role of inert gases in first wall phenomena in fusion devices

    International Nuclear Information System (INIS)

    Das, S.K.

    1979-01-01

    The first wall surfaces of fusion devices will be exposed to bombardment by inert gaseous projectiles such as helium. The flux, energy and angular distribution of the helium radiation will depend not only on the type of device but also on its design parameters. For near term tokamak devices, the first wall surface phenomena caused by helium bombardment that appear to be quite important are physical sputtering and radiation blistering. Examples of these processes for a number of first wall candidate materials are discussed. While the physical sputtering phenomen is well understood, the mechanism of blister formation is still not fully understood. The various models proposed for radiation blistering of metal during helium bombardment is critically reviewed in the light of most recent experimental results

  20. Necrotizing Fasciitis: Diagnostic Challenges in a Mute Bedridden Patient with Atypical Laboratory Parameters

    Directory of Open Access Journals (Sweden)

    Ghan-Shyam Lohiya

    2012-01-01

    Full Text Available A 27-year-old mute bedridden patient required parenteral corticosteroids and antibiotics, and hospitalization for an acute respiratory illness. After 2 days, staff noted a ~0.3 cm blister on the patient’s right heel. Within 19 hours, blistering increased and the foot became partly gangrenous. The patient developed high fever (40.3°C, and leukocytosis (count: 13×109/L; was 6.5×109/L ten days earlier. Necrotizing fasciitis (NF was diagnosed and treated with emergency leg amputation. Histopathology revealed necrosis of fascia, muscle, subcutaneous tissue, and skin. In bedridden patients, corticosteroids may particularly facilitate serious infections, and initial NF blistering may be mistaken for pressure ulcers. Vigilant and frequent whole body monitoring is necessary for all patients incapable of verbalizing their symptoms.

  1. Necrotizing fasciitis: diagnostic challenges in a mute bedridden patient with atypical laboratory parameters.

    Science.gov (United States)

    Lohiya, Ghan-Shyam; Tan-Figueroa, Lilia; Krishna, Vijay; Lohiya, Sunita

    2012-01-01

    A 27-year-old mute bedridden patient required parenteral corticosteroids and antibiotics, and hospitalization for an acute respiratory illness. After 2 days, staff noted a ~0.3 cm blister on the patient's right heel. Within 19 hours, blistering increased and the foot became partly gangrenous. The patient developed high fever (40.3°C), and leukocytosis (count: 13 × 10(9)/L; was 6.5 × 10(9)/L ten days earlier). Necrotizing fasciitis (NF) was diagnosed and treated with emergency leg amputation. Histopathology revealed necrosis of fascia, muscle, subcutaneous tissue, and skin. In bedridden patients, corticosteroids may particularly facilitate serious infections, and initial NF blistering may be mistaken for pressure ulcers. Vigilant and frequent whole body monitoring is necessary for all patients incapable of verbalizing their symptoms.

  2. A Case Report of Angina Bullosa Haemorrhagica (ABH in Patient with Churg Strauss Syndrome

    Directory of Open Access Journals (Sweden)

    M. Koopaie

    2015-11-01

    Full Text Available Bullosa Haemorrhagica (ABH is a rare oral blood blisters disorder. This recurrent disorder is restricted to oral mucosa and its difference with other oral vesiculobullos disorders is that blood vesicles are formed after minor trauma and in the absence of any blood dyscrasia, vesiculobullos disease and systemic disorder. This blood blisters are without pain, with color of dark red and full of bloods that rapidly enlarge and rapidly burst. The incidence of Angina Bullosa Haemorrhagica is unknown. Diagnosis of this disorder and differentiation from vesiculobullos disease like pemphigus and pemphiguid is important for patient's health. In this report we introduce a 55 years old woman with a 4­years history of oral blood blisters. These vesicles were in lateral border and ventral surface of tongue and on the ferenum. In medical history the patient had churg strauss syndrome and using inhalation corticosteroid for control of asthmatic attacks (An etiologic factor for appearing or aggravation of the disease.

  3. Coating degradation at tank bottomdue to settled water

    International Nuclear Information System (INIS)

    Majeed, U.; Rizvi, M.A.; Khan, I.H.

    2008-01-01

    In the present work, coating degradation as a result of settled water on fuel storage tank bottoms has been reported with the help of electrochemical impedance spectroscopy (EIS), blister analysis and gravimetric analysis (water uptake). Blistering occurs underneath the coating at the tank bottom due to direct contact with settled water. Degradation behavior of polyamide epoxy coatings on mild steel has been reported in term of coating resistance at the start of the experiments, after 96 hours and at the end of EIS experiments. Coating degradation in terms of shift in phase angle (theta) at high frequency as a function of exposure time has also been reported. The blister formation and gravimetric analysis data has also been reported in support of EIS result. (author)

  4. Surface mechanical attrition treatment of tungsten and its behavior under low energy deuterium plasma implantation relevant to ITER divertor conditions

    Energy Technology Data Exchange (ETDEWEB)

    Xu, H.Y.; Yuan, Y.; Fu, B.Q.; Godfrey, A.; Liu, W. [Tsinghua Univ.. Lab. of Advanced Materials, Beijing (China); Zhang, Y.B. [Technical Univ. og Denmark. DTU Risoe Campus, Roskilde (Denmark); Tao, N.R. [Chinese Academy of Sciences, Shenyang (China)

    2012-11-01

    In the light of a foreseen application for tungsten (W) as an ITER divertor material samples have been plastically deformed by a surface mechanical attrition treatment (SMAT) and by cold rolling. The resistance to blister formation by low energy deuterium implantation in these samples has been examined, with the result that the structure is significantly improved as the structural scale is reduced to the nanometer range in the SMAT sample. The distribution of blisters in this sample is however bimodal, due to the formation of several very large blisters, which are heterogeneously distributed. The observations suggest that process optimization must be a next step in the development with a view to the application of plastically deformed W in a fusion reactor. (Author)

  5. Anesthetic Approach to a Patient with Epidermolysis Bullosa: A Case Report

    Directory of Open Access Journals (Sweden)

    Ersin KOKSAL

    2015-09-01

    Full Text Available Epidermolysis Bullosa (EB is characterized by fragility and formation of blisters in the skin and mucosal membranes. Due to blisters on the airway and occurring new blisters as a result of anesthetic or surgical procedures may complicate anesthesia management. In this case report, we present the anesthetic approach of a 6 years old case with EB who underwent reconstructive surgery. After premedication and optimal monitorization, intravenous (IV anesthesia and analgesia was administered. Associated with the oropharyngeal lesions and limitation to reach an adequate mouth opening, we preferred the facemask to maintain ventilation. Neither new lesions nor complications were detected during or after surgery. [J Contemp Med 2015; 5(3.000: 192-195

  6. Evaluation of microstructure of irradiated fuel channel components of PHWR

    International Nuclear Information System (INIS)

    Ramadasan, E.

    2005-01-01

    Performance evaluation and failure analysis of irradiated reactor structural components such as those in-core and PHT circuit components necessitate metallographic evaluation using special metallographic specimen preparation techniques due to the radiation dose and contamination levels involved in handling the specimens. The metallographic specimen preparation techniques that are resorted to involve use of fully automatic and semi automatic machines, shielded metallographic microscope and specialised equipment developed for lead-cell metallography. The techniques used and the results obtained in the metallographic studies on irradiated fuel channel components such as pressure tubes and garter springs of various Indian PHWRs at RAPS, NAPS and MAPS are presented as case studies in the paper. The evaluation of oxidation and hydriding behaviour of zircaloy-2 pressure tubes and garter springs are presented. The paper also gives in detail the microstructural evaluation of hydride blistering seen at the PT-CT contact location of the pressure tubes of RAPS-2. The evaluation revealed that the hydride blisters was small compared to their length, unlike the hydride blisters seen in the CANDU pressure tube G-16 of Pickering-2. This could be attributed to be due to the difference in the annulus conditions between the two types of reactors. The hydride blisters in J-07 pressure tube of RAPS-2 had ductile material adjacent to them. The paper also gives the hydride blistering observation on irradiated Zr-2.5% Nb-0.5% Cu garter springs of RAPS-2. It was seen that there was only negligible hydriding of the garter springs during service through they showed presence of benign hydride blisters in them. The general hydriding observations made on the pressure tubes of Indian PHWRs under different conditions are also presented. (author)

  7. Parent artery occlusion for ruptured “true” posterior communicating artery aneurysm

    Science.gov (United States)

    Takeda, Nobuaki; Oishi, Hidenori; Arai, Hajime

    2015-01-01

    A case of a patient with a ruptured true posterior communicating artery (PCoA) aneurysm is reported, who had been managed by early endovascular parent artery occlusion with coils. The small blister aneurysm was located at the proximal PCoA itself and directed superiorly. Postoperative course was uneventful. During 1-month follow-up, the patient recovered well and could care for herself. Aneurysms of the PCoA itself are very rare. As reported to date, surgical procedures would favor microsurgical clipping over endovascular coil embolization. Endovascular treatment may be a good alternative to surgical trapping for true PCoA blister aneurysm. PMID:25953771

  8. Pearling Instabilities of a Viscoelastic Thread

    Science.gov (United States)

    Deblais, A.; Velikov, K. P.; Bonn, D.

    2018-05-01

    Pearling instabilities of slender viscoelastic threads have received much attention, but remain incompletely understood. We study the instabilities in polymer solutions subject to uniaxial elongational flow. Two distinctly different instabilites are observed: beads on a string and blistering. The beads-on-a-string structure arises from a capillary instability whereas the blistering instability has a different origin: it is due to a coupling between stress and polymer concentration. By varying the temperature to change the solution properties we elucidate the interplay between flow and phase separation.

  9. The influence of the ion implantation temperature and the dose rate on smart-cut in GaAs

    International Nuclear Information System (INIS)

    Webb, M.; Jeynes, C.; Gwilliam, R.; Too, P.; Kozanecki, A.; Domagala, J.; Royle, A.; Sealy, B.

    2005-01-01

    The temperature and dose rate dependence of the smart-cut process in GaAs have been investigated in this paper. The distribution of hydrogen and the implantation damage in the samples were studied by ion beam analysis and X-ray diffraction. It was found that at higher temperatures, hydrogen is mobile in the lattice and can rearrange into the platelets, microcracks and bubbles which are present in blistered material, thus relieving the strain in the lattice. The dose rate was also found to be significant for the smart-cut process, as blistering and exfoliation are inhibited at low dose rates

  10. Helium implantation effects in SAP and aluminum

    International Nuclear Information System (INIS)

    Bauer, W.; Thomas, G.J.

    1976-02-01

    A series of 300 keV He implantations of Al and SAP 930 have been conducted at temperatures between 150 and 773K. The He re-emission was monitored during implantation and the samples were examined with a scanning electron microscope after implantation. Both Al and SAP 930 were found to blister after a critical He dose was reached at temperatures above 473K, both underwent flaking below that temperature, with blistering re-appearing in SAP 930 at an implantation temperature of 150K. The surface deformation and He re-emission are strongly dependent on microstructural effects in the intermediate temperature regime

  11. "EB, or Not EB?" Neonatal Desquamative Impetigo in a Degloving Pattern.

    Science.gov (United States)

    Nguyen, Tuyet A; Wang, Audrey S; Eichenfield, Lawrence F; Barrio, Victoria

    2016-01-01

    We present the case of a 7-day-old boy with significant, rapidly spreading blistering and desquamation in a "degloving" pattern on the hands that mimicked epidermolysis bullosa but was ultimately diagnosed as bullous impetigo caused by a clinically aggressive strain of Staphylococcus aureus. Bullous impetigo is a desquamating condition caused by local release of S. aureus exfoliative toxin A and is more commonly seen in children. This case highlights the fragility of newborn skin and reviews the major diagnoses that should be considered in an infant with significant blistering. © 2016 Wiley Periodicals, Inc.

  12. Erythema gyratum repense like eruption in bullous pemphigoid: A case report

    Directory of Open Access Journals (Sweden)

    Hojat Eftekhari

    2016-07-01

    Full Text Available Bullous pemphigoid (BP is an autoimmune disease characterized by presence of bullous eruption on the trunk and extremities especially flexural aspects of the limbs. This disease usually occurs in the elderly. The initial presentation of BP is variable. An urticarial or erythematous rash may precede the appearance of the blister formation and can be associated with itch or pruritus. We presented 87 year old bedridden man diagnosed with BP who initially presented with erythema gyratum repens like eruption before blister formation. This case report discusses the presentation of figurate erythema in non-bullous phase of BP for clinicians.

  13. Noncrucial role of the defects in the splitting for hydrogen implanted silicon with high boron concentration

    International Nuclear Information System (INIS)

    Popov, V.P.; Stas, V.F.; Antonova, I.V.

    1999-01-01

    The present work deals with the investigation of the electrical and structural properties of heavily boron-doped silicon irradiated by hydrogen. Blistering and splitting processes are enhanced with an increase in boron concentration in the crystal. The measured values of perpendicular strain are over 0.7% which corresponds to a gas overpressure of 0.5 GPa. Processes which lead to blistering and splitting is better described in the frame of a gas pressure model than a model of local stress caused by the defects

  14. Analysis of vesicle fluid following the sting of the lionfish Pterois volitans.

    Science.gov (United States)

    Auerbach, P S; McKinney, H E; Rees, R S; Heggers, J P

    1987-01-01

    Fluid aspirated from blisters following a lionfish (Pterois volitans) sting was analyzed utilizing combined capillary column gas chromatography and negative ion chemical ionization mass spectrometry. Analysis for prostaglandin F2 alpha demonstrated 16.91 ng/ml, for prostaglandin E2 0.143 ng/ml, for 6-keto-prostaglandin F1 alpha less than 0.1 ng/ml (nondetectable) and for thromboxane B2 1.65 ng/ml. Platelet aggregation studies showed that blister fluid caused aggregation of isolated platelets only, which was inhibited by heat treatment or by the presence of normal donor plasma.

  15. Characterization of a novel tymovirus on tomato plants in Brazil.

    Science.gov (United States)

    de Oliveira, Virgínia Carla; Nagata, Tatsuya; Guimarães, Felipe C; Ferreira, Fernanda A; Kitajima, Elliot Watanabe; Nicolini, Cícero; de Oliveira Resende, Renato; Inoue-Nagata, Alice Kazuko

    2013-02-01

    A tymovirus was isolated in Brazil from tomato plants with severe symptoms of leaf mosaic and blistering. The virus was mechanically transmissible to solanaceous indicator host species. The infected plants contained icosahedral particles and chloroplasts with membrane deformations which are typical cytopathic effects caused by tymoviruses. Its coat protein amino acid sequence shares the maximum of 64 % identity with the tymovirus Chiltepin yellow mosaic virus, which suggested that it can be considered as a distinct member of the genus Tymovirus. In a phylogenetic tree, this tymovirus was clustered with other solanaceous-infecting tymoviruses. It was tentatively named as Tomato blistering mosaic virus (ToBMV).

  16. Pemphigus. S2 Guideline for diagnosis and treatment - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)

    NARCIS (Netherlands)

    Hertl, M.; Jedlickova, H.; Karpati, S.; Marinovic, B.; Uzun, S.; Yayli, S.; Mimouni, D.; Borradori, L.; Feliciani, C.; Ioannides, D.; Joly, P.; Kowalewski, C.; Zambruno, G.; Zillikens, D.; Jonkman, M. F.

    BACKGROUND: Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions of the mucous membranes and skin. Before the era of immunosuppressive treatment, the prognosis of pemphigus was almost fatal. Due to its rarity, only few prospective

  17. Geographic patterns of genetic variation and population structure in Pinus aristata, Rocky Mountain bristlecone pine

    Science.gov (United States)

    Anna W. Schoettle; Betsy A. Goodrich; Valerie Hipkins; Christopher Richards; Julie Kray

    2012-01-01

    Pinus aristata Engelm., Rocky Mountain bristlecone pine, has a narrow core geographic and elevational distribution, occurs in disjunct populations, and is threatened by rapid climate change, white pine blister rust, and bark beetles. Knowledge of genetic diversity and population structure will help guide gene conservation strategies for this species. Sixteen sites...

  18. Paint Failures on Ran Minehunter Vessels: The Effect of Surface Condition on Adhesion of Paints to Immersed GRP

    Science.gov (United States)

    1990-10-01

    141 that the use of neopentyl glycol produces laminates with greater blister resistance because the two methyl groups provide steric protection of...It is known that susceptibility of the ester linkage to hydrolysis is also reduced by increasing the size of the glycol unit 1101, e.g. it is clairned

  19. Mothers Perception of Teething in Children

    African Journals Online (AJOL)

    TNHJOURNALPH

    includes blistering, bleeding, placing leeches on the gum, applying cautery to the back of the head and lancing- a method where lancet was used to cut the gum in other for the teeth to appear.7 1t was thought that failure of the teeth to appear was due to lack of a pathway and that this was the cause of death from teething,.

  20. Oral purpura as the first manifestation of primary systemic amyloidosis.

    Science.gov (United States)

    McCormick, Robert Stuart; Sloan, Philip; Farr, David; Carrozzo, Marco

    2016-07-01

    Oral blood blisters and purpura are rare features of primary systemic amyloidosis (amyloid light-chain (AL) amyloidosis). We report a case in which these unusual presentations led to a diagnosis of amyloidosis, which enabled effective treatment before organ failure. Copyright © 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  1. Experimental Study of Heat Dissipation in Indoor Sports Shoes

    NARCIS (Netherlands)

    Dessing, O.; Jansen, A.J.; Leihitu, C.; Overhage, D.

    2014-01-01

    As indoor sports shoes are intensively used in a warm and sweaty environment for periods of up to three consecutive hours, the built-up heat inside is insufficiently released causing warm and perspiring feet. This results in an increased chance of blisters and skin irritations. Experimental research

  2. Natural Gene Therapy in Dystrophic Epidermolysis Bullosa

    NARCIS (Netherlands)

    van den Akker, Peter C.; Nijenhuis, Albertine; Hofstra, Robert M. W.; Jonkman, Marcel F.; Pasmooij, Anna M. G.; Meijer, G.

    Background: Dystrophic epidermolysis bullosa is a genetic blistering disorder caused by mutations in the type VII collagen gene, COL7A1. In revertant mosaicism, germline mutations are corrected by somatic events resulting in a mosaic disease distribution. This "natural gene therapy" phenomenon long

  3. Climate influences on whitebark pine mortality from mountain pine beetle in the Greater Yellowstone Ecosystem

    Science.gov (United States)

    Polly C. Buotte; Jeffrey A. Hicke; Haiganoush K. Preisler; John T. Abatzoglou; Kenneth F. Raffa; Jesse A. Logan

    2016-01-01

    Extensive mortality of whitebark pine, beginning in the early to mid-2000s, occurred in the Greater Yellowstone Ecosystem (GYE) of the western USA, primarily from mountain pine beetle but also from other threats such as white pine blister rust. The climatic drivers of this recent mortality and the potential for future whitebark pine mortality from mountain pine beetle...

  4. 76 FR 31171 - Importation of Plants for Planting; Establishing a Category of Plants for Planting Not Authorized...

    Science.gov (United States)

    2011-05-27

    ... photosensitizes the skin of humans, leading to photodermatitis, which results in painful and lasting blisters. Sap... resources. The regulations in 7 CFR part 360, ``Noxious Weed Regulations,'' contain prohibitions and... to U.S. agricultural and environmental resources, meaning they can only be moved under a permit...

  5. 7 CFR 51.3157 - Damage.

    Science.gov (United States)

    2010-01-01

    ...) When the skin is blistered, cracked, or decidedly flattened; (2) When the normal color of the skin or... exceeds three-sixteenths inch in diameter; (c) Scab or bacterial spot when cracked, or when the aggregate... one-fourth inch in diameter; (e) Drought spots or external gum spots which have an aggregate area...

  6. 7 CFR 51.317 - Damage.

    Science.gov (United States)

    2010-01-01

    ... of more than one-half inch in diameter. (4) Red skin spots which are thinly scattered over more than... diameter. (b) Sunburn or sprayburn which has caused blistering or cracking of the skin, or when the.... (d) Hail marks, drought spots, other similar depressions, or scars: (1) When any unhealed mark is...

  7. 7 CFR 51.1280 - Serious damage.

    Science.gov (United States)

    2010-01-01

    ... inch in diameter, or which materially deform or disfigure the fruit. 2 (3) Drought spot when more than... discoloration. 2 (4) Sunburn or sprayburn where the skin is blistered, cracked or shows any brownish color, or...) Disease: (i) Scab spots which are black and which cover an aggregate area of more than one-half inch in...

  8. Hydrogen embrittlement in power plant steels

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    cause of blistering is well-known, handling and finishing techniques have been developed to minimize this form of damage. Vacuum melting and degassing minimize the quantity of hydrogen in the steels. Acid pickling and other such processes that may introduce hydrogen are avoided when practical, and possible moisture ...

  9. After 100 years, is coevolution relevant?

    Science.gov (United States)

    Geral I. McDonald

    2011-01-01

    On the 100th anniversary of the introduction of Cronartium ribicola into western North America, it is fitting to assess the philosophical foundation of plant pathology and forest ecology. We should ask whether this foundation provides sufficient understanding of blister rust, other diseases of North American forests, and general forest ecology to insure the application...

  10. Re-measurement of whitebark pine infection and mortality in the Canadian Rockies

    Science.gov (United States)

    Cyndi M. Smith; Brenda Shepherd; Cameron Gillies; Jon Stuart-Smith

    2011-01-01

    Whitebark pine (Pinus albicaulis) populations are under threat across the species' range from white pine blister rust (Cronartium ribicola), mountain pine beetle (Dendroctonus ponderosae), fire exclusion and climate change (Tomback and Achuff 2010). Loss of whitebark pine is predicted to have cascading effects on the following ecological services: provision of...

  11. Limber pine seed and seedling planting experiment in Waterton Lakes National Park, Canada

    Science.gov (United States)

    Cyndi M. Smith; Graeme Poll; Cameron Gillies; Celina Praymak; Eileen Miranda; Justin Hill

    2011-01-01

    Limber pine plays an important role in the harsh environments in which it lives, providing numerous ecological services, especially because its large, wingless seeds serve as a high energy food source for many animals. Limber pine populations are declining due to a combination of white pine blister rust, mountain pine beetle, drought, and fire suppression. Outplanting...

  12. Kidney failure in mice lacking the tetraspanin CD151

    NARCIS (Netherlands)

    Sachs, Norman; Kreft, Maaike; van den Bergh Weerman, Marius A.; Beynon, Andy J.; Peters, Theo A.; Weening, Jan J.; Sonnenberg, Arnoud

    2006-01-01

    The tetraspanin CD151 is a cell-surface molecule known for its strong lateral interaction with the laminin-binding integrin alpha3beta1. Patients with a nonsense mutation in CD151 display end-stage kidney failure associated with regional skin blistering and sensorineural deafness, and mice lacking

  13. Kidney failure in mice lacking the tetraspanin CD151.

    NARCIS (Netherlands)

    Sachs, N.; Kreft, M.; Bergh Weerman, M. van der; Beynon, A.J.; Peters, T.A.; Weening, J.J.; Sonnenberg, A.

    2006-01-01

    The tetraspanin CD151 is a cell-surface molecule known for its strong lateral interaction with the laminin-binding integrin alpha3beta1. Patients with a nonsense mutation in CD151 display end-stage kidney failure associated with regional skin blistering and sensorineural deafness, and mice lacking

  14. Bug bites and stings: When to see a dermatologist

    Medline Plus

    Full Text Available ... 0; c public SPOT Skin Cancer™ Diseases and treatments Skin, hair, and nail care Skin care Hair care / hair loss Injured skin Blisters Bug bites and stings How to remove a tick How to treat a bee sting When to see a dermatologist Burns Frostbite Splinters Treating sunburn Wound care Nail care ...

  15. Damage phenomena of thin hard coatings submitted to repeated impacts: Influence of the substrate and film properties

    Energy Technology Data Exchange (ETDEWEB)

    Lamri, S. [IRTES-LERMPS, EA 7274, UTBM, 90 010 Belfort Cedex (France); ICD-LASMIS, UTT antenne de Nogent, Rue Lavoisier, 52800 Nogent (France); Langlade, C., E-mail: cecile.langlade@utbm.fr [IRTES-LERMPS, EA 7274, UTBM, 90 010 Belfort Cedex (France); Kermouche, G. [LTDS Laboratory, UMR CNRS 5513, ENI St Etienne (France); UMR CNRS 5146, Ecole des Mines de St-Etienne, Centre SMS, 158 Cours Fauriel, 42100 St-Etienne (France)

    2013-01-10

    To evaluate the surface fatigue resistance of some thin nitride films obtained by Physical Vapour Deposition (PVD) techniques, repeated impact tests have been performed under controlled impact conditions. Short and long duration tests have revealed the occurrence of an original damage phenomenon likely linked to a mechanical blistering of the films. As these blisters appear to be the first damage step, their formation has to be understood in order to be avoided in industrial applications. In particular, the role of the mechanical properties of the substrate has to be clarified as thin protective coatings may be used on pieces prepared using various heat treatments. finite element method (FEM) analysis has been conducted in order to better understand the specific mechanical conditions in the substrate and at the film-substrate interface that could lead to such blistering phenomena. Correlations with the experimental results have been evidenced. From the modelling results the substrate properties have been shown to be of significant influence on the blister formation. However as they do not fully explain the origin of this phenomenon, the influence of the substrate microstructure has also been studied and the presence of vanadium carbides appears to be of major effect.

  16. Causes of early neonatal respiratory distress in the former Venda - a ...

    African Journals Online (AJOL)

    respiratory distress in the newborn in Western Europe ... cell count. Positive clinical findings are an enlarged liver or spleen, skin petechiae or blisters, or a positive rapid plasma reagin (RPR) test. A positive maternal history features intrapartum fever above ..... Stem H. Elhs U. The low birth weight Af"can baby. Arch Dts Child ...

  17. Audio 2008--Alternative Rock: Forced Exposure Is Good for You

    Science.gov (United States)

    Pasteur, Eric

    2008-01-01

    According to this author, alternative rock did not deserve what it became in the post-Nirvana 1990s. Reduced to a marketing catch-phrase--effectively rendering it meaningless--major label co-optation helped blur the line between artistic expression and cloned sounds. Before Nirvana broke through to the mainstream with the blistering sarcasm of its…

  18. The proactive strategy for sustaining five-needle pine populations: An example of its implementation in the southern Rocky Mountains

    Science.gov (United States)

    A. W. Schoettle; B. A. Goodrich; J. G. Klutsch; K. S. Burns; S. Costello; R. A. Sniezko

    2011-01-01

    The imminent invasion of the non-native fungus, Cronartium ribicola J.C. Fisch., that causes white pine blister rust (WPBR) and the current mountain pine beetle (Dendroctonus ponderosae Hopkins, MPB) epidemic in northern Colorado limber pine forests will severely affect the forest regeneration cycle necessary for functioning ecosystems. The slow growth and maturity of...

  19. Population biology of sugar pine (Pinus lambertiana Dougl.) with reference to historical disturbances in the Lake Tahoe Basin: implications for restoration

    Science.gov (United States)

    Patricia E. Maloney; Detlev R. Vogler; Andrew J. Eckert; Camille E. Jensen; David B. Neale

    2011-01-01

    Historical logging, fire suppression, and an invasive pathogen, Cronartium ribicola, the cause of white pine blister rust (WPBR), are assumed to have dramatically affected sugar pine (Pinus lambertiana) populations in the Lake Tahoe Basin. We examined population- and genetic-level consequences of these disturbances within 10...

  20. The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila.

    Directory of Open Access Journals (Sweden)

    Reto Müller

    Full Text Available The O-GlcNAc transferase Eogt modifies EGF repeats in proteins that transit the secretory pathway, including Dumpy and Notch. In this paper, we show that the Notch ligands Delta and Serrate are also substrates of Eogt, that mutation of a putative UDP-GlcNAc binding DXD motif greatly reduces enzyme activity, and that Eogt and the cytoplasmic O-GlcNAc transferase Ogt have distinct substrates in Drosophila larvae. Loss of Eogt is larval lethal and disrupts Dumpy functions, but does not obviously perturb Notch signaling. To identify novel genetic interactions with eogt, we investigated dominant modification of wing blister formation caused by knock-down of eogt. Unexpectedly, heterozygosity for several members of the canonical Notch signaling pathway suppressed wing blister formation. And importantly, extensive genetic interactions with mutants in pyrimidine metabolism were identified. Removal of pyrimidine synthesis alleles suppressed wing blister formation, while removal of uracil catabolism alleles was synthetic lethal with eogt knock-down. Therefore, Eogt may regulate protein functions by O-GlcNAc modification of their EGF repeats, and cellular metabolism by affecting pyrimidine synthesis and catabolism. We propose that eogt knock-down in the wing leads to metabolic and signaling perturbations that increase cytosolic uracil levels, thereby causing wing blister formation.

  1. Helium ion damage in an amorphous Fe-Ni-Mo-B alloy

    International Nuclear Information System (INIS)

    Swijgenhoven, H. van; Stals, L.M.; Knuyt, G.

    1983-01-01

    Data are presented on helium gas bubble and helium blister formation for Metglas 2826MB during 5 keV He + -implantation in the temperature range 200K-600K and dose range 5.10 20 -10 22 He + /m 2 . It is concluded that amorphous alloys are less radiation resistant as has been thought earlier. (author)

  2. Native ectomycorrhizal fungi of limber and whitebark pine: Necessary for forest sustainability?

    Science.gov (United States)

    Cathy L. Cripps; Robert K. Antibus

    2011-01-01

    Ectomycorrhizal fungi are an important component of northern coniferous forests, including those of Pinus flexilis (limber pine) and P. albicaulis (whitebark pine) which are being decimated by white pine blister rust and mountain pine beetles. Ectomycorrhizal fungi are known to promote seedling establishment, tree health, and may play a role in forest sustainability....

  3. In vivo UVB irradiation induces clustering of Fas (CD95) on human epidermal cells

    DEFF Research Database (Denmark)

    Bang, Bo; Gniadecki, Robert; Larsen, Jørgen K

    2003-01-01

    a single dose of UVB irradiation. Normal healthy individuals were irradiated with three minimal erythema doses (MED) of UVB on forearm or buttock skin. Suction blisters from unirradiated and irradiated skin were raised, and Fas, FasL, and apoptosis of epidermal cells quantified by flow cytometry...

  4. Novel protease-based diagnostic devices for detection of wound infection

    NARCIS (Netherlands)

    Heinzle, A.; Papen-Botterhuis, N.E.; Schiffer, D.; Schneider, K.P.; Binder, B.; Schintler, M.; Haaksman, I.K.; Lenting, H.B.; Gübitz, G.M.; Sigl, E.

    2013-01-01

    A gelatinase-based device for fast detection of wound infection was developed. Collective gelatinolytic activity in infected wounds was 23 times higher (p ≤ 0.001) than in noninfected wounds and blisters according to the clinical and microbiological description of the wounds. Enzyme activities of

  5. Erythema elevatum diutinum in association with dermatitis herpetiformis

    Directory of Open Access Journals (Sweden)

    Shanmuga Sekar Chandrasekaran

    2014-01-01

    Full Text Available Erythema elevatum diutinum (EED is a rare skin disease that initially presents as leucocytoclastic vasculitis and later resolves with fibrosis. Dermatitis herpetiformis is an autoimmune blistering disease characterized by granular deposits of immunoglobulin A (IgA in dermal papillae. We report a rare association of these two disorders.

  6. Energy-saving by the optimization of the operation conditions in the vinylcloride lining steel pipe baking furnace. Enbirainingu kokan yakitsukero no sogyo joken saitekika ni yoru sho energy

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, Y. (Kawasaki Steel Corp., Tokyo (Japan))

    1991-02-04

    By the investigation of the operation conditions in the small experimental furnace, the improvement of the heat pattern of the steel pipes, and the remodeling and arrangement of the furnace, the progress of the yield and the productivity, and the reduction of the fuel unit were expected. In baking of a PVC pipe with a steel pipe, defects of PVC pipes as the blister of the inner surface occurred often. Accordingly the conditions when the blister occurred were investigated in the experimental furnace and optimized operation conditions when it does not occur were established. Next the flow rate of the hot air and the temperature distribution in the actual furnace were examined and the mechanism of occurrence of the defects of the blister of the inner surface was investigated. As a result, it was proved that the deviation of the hot air flux and the intrusion of the outer air cause it, and the places where the outer air intruded were closed by steel plates. After the improvements the rate of the defects of PVC pipes of the blister of the inner surface was decreased from 5% to 0.5%. Further, by the optimization of the operation conditions the fuel unit decreased and 31% of the rate of the energy-saving was achieved. The reduction of 10,414,000 yen a year was achieved. 29 figs., 4 tabs.

  7. Inheritance of the bark reaction resistance mechanism in Pinus monticola infected by Cronartium ribicola

    Science.gov (United States)

    Ray J. Hoff

    1986-01-01

    Necrotic reactions in branch or main stems of western white pine (Pinus monticola Dougl.) caused by infection by the blister rust fungus (Cronartium ribicola J. C. Fisch. ex Rabenh.) are a major mechanism of resistance. Overall, 26 percent of the seedlings eliminated the fungus via this defense system. Heritability based upon crossing family groups averaged 33 percent...

  8. Two Models of Adhesive Debonding of Sylgard

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, Ralph Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-03-14

    This report begins with a brief summary of the range of modeling methods used to simulate adhesive debonding. Then the mechanical simulation of the blister debonding test, and the thermomechanical simulation of the potted hemisphere problem are described. For both simulations, details of the chosen modeling techniques, and the reasons for choosing them (and rejecting alternate modeling approaches) will be discussed.

  9. Symptoms associated in the diagnosis and management of malaria ...

    African Journals Online (AJOL)

    Symptomatic diagnosis of the 352 pregnant women and children, showed that 260 (79%) did not manifest any of the malarial symptoms within the past three months as at the time of the study, 20 (5.7%) patients had fever alone, chill and blisters (0.9%), headache, diarrhoea and joint pain (0.3%), and weakness and anorexia ...

  10. Development of Sub-Ischial Prosthetic Sockets with Vacuum-Assisted Suspension for Highly Active Persons with Transfemoral Amputations

    Science.gov (United States)

    2013-10-01

    inner and outer-most layers). However, the carbon and kevlar frame materials were replaced by polypropylene that was blister formed and trimmed to form...attach the pyramid adapters and the bolts screwed into these holes were secured with an epoxy resin. An image of the final hybrid pump prototype is

  11. Pedicularis and Castilleja are natural hosts of Cronartium ribicola in North America: A first report

    Science.gov (United States)

    Geral I. McDonald; Bryce A. Richardson; Paul J. Zambino; Ned B. Klopfenstein; Mee-Sook Kim

    2006-01-01

    White pine blister rust disease, caused by the introduced pathogen Cronartium ribicola, has severely disrupted five-needled pine ecosystems in North America. A 100-year effort to manage this disease was predicated in part on the premise that the pathogen utilizes only species of Ribes (Grossulariaceae) as...

  12. Interaction of implanted deuterium and helium with beryllium: radiation enhanced oxidation

    Energy Technology Data Exchange (ETDEWEB)

    Langley, R.A.

    1979-01-01

    The interaction of implanted deuterium and helium with beryllium is of significant interest in the application of first wall coatings and other components of fusion reactors. Electropolished polycrystalline beryllium was first implanted with an Xe backscatter marker at 1.98 MeV followed by either implantation with 5 keV diatomic deuterium or helium. A 2.0 MeV He beam was used to analyze for impurity buildup; namely oxygen. The oxide layer thickness was found to increase linearly with increasing implant fluence. A 2.5 MeV H/sup +/ beam was used to depth profile the D and He by ion backscattering. In addition the retention of the implant was measured as a function of the implant fluence. The mean depth of the implant was found to agree with theoretical range calculations. Scanning electron microscopy was used to observe blister formation. No blisters were observed for implanted D but for implanted He blisters occurred at approx. 1.75 x 10/sup 17/ He cm/sup -2/. The blister diameter increased with increasing implant fluence from about 0.8 ..mu..m at 10/sup 18/ He cm/sup -2/ to 5.5 ..mu..m at 3 x 10/sup 18/ He cm/sup -2/.

  13. Staying Up in a Down Economy

    Science.gov (United States)

    Pulley, John

    2009-01-01

    The fundraising landscape has been blistered by stock-market meltdowns and a financial sector that has repeatedly erupted in flames. In turn, the environment for development has turned icy, cooled by frozen credit markets and chilly consumer confidence. It is ragged, unstable terrain. Fundraisers, the ground moving beneath them, are unsure of…

  14. Genetic diversity and structure of western white pine (Pinus monticola) in North America: A baseline study for conservation, restoration, and addressing impacts of climate change

    Science.gov (United States)

    Mee-Sook Kim; Bryce A. Richardson; Geral I. McDonald; Ned B. Klopfenstein

    2010-01-01

    Western white pine (Pinus monticola) is an economically and ecologically important species in western North America that has declined in prominence over the past several decades, mainly due to the introduction of Cronartium ribicola (cause of white pine blister rust) and reduced opportunities for regeneration. Amplified fragment length polymorphism (AFLP) markers were...

  15. Parameters for Estimation of Casualties from Ammonia (NH3), Tabun (GA), Soman (GD),Cyclosarin (GF) and Lewisite (L)

    Science.gov (United States)

    2015-09-01

    untreated casualty estimate, AMedP-7.5 uses the Injury Profile to deter- mine the final outcome for each Injury Profile cohort. For a treated casualty...materially from that of an HD burn. Large, single coalescent blisters with sharply defined margins are filled with cloudy and opales - cent fluid, and the

  16. Analysis system for characterisation of simple, low-cost microfluidic components

    CSIR Research Space (South Africa)

    Smith, S

    2014-03-01

    Full Text Available mechanism is used to introduce and dispense a sample of blood, while a reagent is released into the microfluidic system through compression and bursting of a blister pack. Mixing and dispensing of the sample and reagent are facilitated via air actuation...

  17. National Infrastructure Advisory Council: Chemical, Biological, and Radiological Events and the Critical Infrastructure Workforce. Final Report and Recommendations

    Science.gov (United States)

    2008-01-08

    inbound and outbound products and materials, and products for distribution and product stewardship activities. The CSCC was the first Sector...for Nuclear and Radiological Terrorism” published in April 2006 addressed many of the 73 tactical logistical elements surrounding first response...including blisters, burns, vomiting, reddened skin, etc. o Residents faced nation-wide discrimination, including inability to travel, secure hotel rooms

  18. Stopping Shingles (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    Shingles, also known as herpes zoster, is a disease characterized by a painful skin rash, with blisters usually occurring on one side of the body. Each year, approximately one million people in the U.S. get the disease. In this podcast, Dr. Mark Pallansch discusses a newly approved vaccine to prevent shingles.

  19. Gene conservation of Pinus aristata: a collection with ecological context for management today and resources for tomorrow

    Science.gov (United States)

    A.W. Schoettle

    2017-01-01

    Pinus aristata, Rocky Mountain bristlecone pine, has a narrow geographic and elevational distribution and is threatened by rapid climate change, the introduced pathogen Cronartium ribicola that causes white pine blister rust (WPBR), and bark beetles. The core distribution of P. aristata is near and at treeline in central and southern Colorado and...

  20. Bone setter's gangrene | Nwadiaro | Nigerian Journal of Medicine

    African Journals Online (AJOL)

    Abstract. Background: Gangrene usually supervenes following prolonged pressure of tight splintage by traditional bone setters (TBS) in the process of treating fractures. However, various complications such as blisters, pressure sores, Volkmann's ischaemia/ contracture, Crush syndrome and pregangrene occur by the same ...

  1. Children with Rare Chronic Skin Diseases: Hemangiomas and Epidermolysis Bullosa.

    Science.gov (United States)

    Jones, Sheila Dove; Miller, Cynthia Dieterich

    The paper reports on studies involving children having the rare chronic skin diseases of hemangiomas and epidermolysis bullosa (characterized by easy blistering). One study compared the self-concept and psychosocial development of young (mean age 46 months) children (N=19) with hemangiomas with 19 children without hemangiomas. Findings indicated…

  2. Managing High Blood Pressure Medications

    Science.gov (United States)

    ... pharmacist to help you come up with a coding system for your medications that makes them easier to take. Some pharmacists will prepare blister packs for daily or weekly medications. Make an instruction sheet for yourself by taping a sample of each ...

  3. Medications for Arrhythmia

    Science.gov (United States)

    ... pharmacist to help you come up with a coding system for your medications that makes them easier to take. Some pharmacists will prepare blister packs for daily or weekly medications. Make an instruction sheet for yourself by taping a sample of each ...

  4. A POW'S STORY

    African Journals Online (AJOL)

    with automatic guns,. and in the blistering heat we were marched from ... No hygiene system at all. We are now on ... wash. Rations same as previous day. Nothing exciting all day. 30th June. Early this ..... In this way we car-. -ied on for days, ...

  5. Health, reproduction, and fuels in whitebark pine in the Frank Church River of No Return Wilderness Area in central Idaho (Project INT-F-05-02)

    Science.gov (United States)

    Lauren Fins; Ben Hoppus

    2013-01-01

    Whitebark pine (Pinus albicaulis Engelm.) is in serious decline across its range, largely due to the combined effects of Cronartium ribicola J. C. Fisch (an introduced fungal pathogen that causes white pine blister rust), replacement by late successional species, and widespread infestation of mountain pine beetle (...

  6. Degradation mechanisms of organic rubber and glass flake/vinyl ester linings in flue gas desulphurization plants

    Energy Technology Data Exchange (ETDEWEB)

    Weber, R [Allianz-Centre for Technology GmbH, Ismaning (Germany)

    1996-12-01

    In recent years, there have been reports in numerous publications about damage to rubber and glass flake coatings in flue gas desulphurization plants. The pattern of damage has been described and attempts have frequently been made to determine and explain the cause of the damage. Oxidation/hydrolytic changes were generally observed as the damage mechanisms. In addition, blistering occurs in both the chloroprene coatings in the absorbers and in the glass flake coatings in clean gas ducts. This blistering may be considered as the end of the useful life and leads to cost-intensive and time-intensive repair and restoration measures. The present state of knowledge suggests that the blistering is mainly due to osmotic processes preceded by permeation processes and with permeation processes superimposed on them. Among other things, the reports describe the permeation behaviour of water and other flue gas constituents; the blistering in chloroprene rubber coatings and glass flake coatings is explained by means of the knowledge gained. (au) 16 refs.

  7. Knowledge and beliefs about sexually transmitted infections among ...

    African Journals Online (AJOL)

    0.021), blisters on the penis (p=0.033) and clear vaginal discharge (p=0.021). These results indicate that learners have poor and inadequate knowledge about STIs. The study, therefore, recommends that all School Health Promotion programmes ...

  8. Regeneration of Rocky Mountain bristlecone pine (Pinus aristata) and limber pine (Pinus flexilis) three decades after stand-replacing fires

    Science.gov (United States)

    Jonathan D. Coop; Anna W. Schoettle

    2009-01-01

    Rocky Mountain bristlecone pine (Pinus aristata) and limber pine (Pinus flexilis) are important highelevation pines of the southern Rockies that are forecast to decline due to the recent spread of white pine blister rust (Cronartium ribicola) into this region. Proactive management strategies to promote the evolution of rust resistance and maintain ecosystem function...

  9. Method and means of reducing erosion of components of plasma devices exposed to helium and hydrogen isotope radiation

    International Nuclear Information System (INIS)

    Kaminsky, M.S.; Das, S.K.; Rossing, T.D.

    1977-01-01

    Surfaces of components of plasma devices exposed to radiation by atoms or ions of helium or isotopes of hydrogen can be protected from damage due to blistering by shielding the surfaces with a structure formed by sintering a powder of aluminum or beryllium and its oxide or by coating the surfaces with such a sintered metal powder. 7 claims

  10. The Impact Of Community-Directed Administration Of Various ...

    African Journals Online (AJOL)

    ... the CMCs and PMVs with the essential antimalarial drug, chloroquine (CQ) packaged in various age-specific plastic bottles, compartmentalized polythene bags and blister packs. Of the 3,000 pre-packs delivered in 4 instalments from January to November 1998, 2503 were sold under a subsidized cost-recovery scheme.

  11. Camphor Burns on the Palm: An Unusual New Presentation

    African Journals Online (AJOL)

    in the center), and Type 3 (a full‑thickness burn exposing the palmar fascia). Conclusion: Different types of camphor burns on the palm are described in this study. This is the first study to report ring‑shaped blisters and ring‑shaped partially thick camphor burns caused on the palm. KEYWORDS: Camphor, palm burn, ring ...

  12. Guide to Canadian Aerospace Related Industries,

    Science.gov (United States)

    1986-02-28

    Canadair, de Havilland Aircraft of Canada, Government of Precision Engraving; Custom Packaging; Blister Packaging. Malaysia and many other corporate...formal projects and special assign- Frequency Control (Crystals). ments for EPA (US), Cal OSHA , USDA, US Gas Research Revised: Sep 85 Keywords: Test

  13. Analytical tools and methodologies for evaluation of residual life of contacting pressure tubes in the early generation of Indian PHWRs

    International Nuclear Information System (INIS)

    Sinha, S.K.; Madhusoodanan, K.; Rupani, B.B.; Sinha, R.K.

    2002-01-01

    In-service life of a contacting Zircaloy-2 pressure tube (PT) in the earlier generation of Indian PHWRs, is limited mainly due to the accelerated hydrogen pick-up and nucleation and growth of hydride blister(s) at the cold spot(s) formed on outside surface of pressure tube as a result of its contact with the calandria tube (CT). The activities involving development of the analytical models for simulating the degradation mechanisms leading to PT-CT contact and the methodologies for the revaluation of their safe life under such condition form the important part of our extensive programme for the life management of contacting pressure tubes. Since after the PT-CT contact, rate of hydrogen pick-up and nucleation and growth of hydride blisters govern the safe residual life of the pressure tube, two analytical models (a) hydrogen pick-up model ('HYCON') and (b) model for the nucleation and growth of hydride blister at the contact spot ('BLIST -2D') have been developed in-house to estimate the extent of degradation caused by them. Along with them, a methodology for evaluation of safe residual life has also been formulated for evaluating the safe residual life of the contacting channels. This paper gives the brief description of the models and the methodologies relevant for the contacting Zircaloy-2 pressure tubes. (author)

  14. 78 FR 45845 - Airworthiness Directives; Bell Helicopter Textron Helicopters

    Science.gov (United States)

    2013-07-30

    ..., whichever occurs first, cleaning and visually inspecting each T/R blade assembly for a crack, corrosion... be covered under warranty, thereby reducing the cost impact on affected individuals. We do not... a crack, corrosion (may be indicated by blistering, peeling, flaking, bubbling, or cracked paint), a...

  15. The examination of the ruptured Zircaloy-2 pressure tube from Pickering NGS Unit 2

    International Nuclear Information System (INIS)

    Cheadle, B.A.; Smith, A.D.; Baskin, C.C.

    1985-07-01

    On 1983 August 01 a Zircaloy-2 pressure tube in Pickering NGS Unit 2 ruptured. All the fuel channel components, the fuel bundles, pressure tube, end fittings, garter springs and calandria tubes were shipped to Chalk River Nuclear Laboratories for examination to determine the cause of the rupture. The examination showed that the rupture initiated at a series of hydride blisters on the outside surface of the pressure tube. The blisters formed because of the garter spring spacers between the pressure tube and calandria tube was about one metre out of position. This allowed the horizontal pressure tube to sag by creep and touch the cool calandria tube. The resulting thermal gradients in the pressure tube concentrated the hydrogen and deuterium at the cool zones and blisters of solid hydride formed. Cracks initiated at several of the blisters and linked together to form a partial through wall critical crack which initiated the final rupture. The video presentation shows how the examination of the fuel channel components was conducted in underwater bays and shielded cells and explains the sequence of events that caused the rupture

  16. Sex Pheromone of Conophthorus ponderosae (Coleoptera: Scolytidae) in a Coastal Stand of Western White Pine (Pinaceae)

    Science.gov (United States)

    Daniel R. Miller; Harold D. Pierce; Peter de Groot; Nicole Jeans-Williams; Robb Bennett; John H. Borden

    2000-01-01

    An isolated stand of western white pine, Pinus monticola Dougl. ex D. Don, on Texada Island (49°40'N, 124°10'W), British Columbia, is extremely valuable as a seed-production area for progeny resistant to white pine blister rust, Cronartium ribicola J.C. Fisch. (Cronartiaceae). During the past 5 years, cone beetles, ...

  17. Revertant cell therapy for epidermolysis bullosa

    NARCIS (Netherlands)

    Gostynski, Antoni

    2014-01-01

    Epidermolysis bullosa (EB) is an inherited skin disease. Patients have lifelong fragile skin leading to chronic blistering of the skin and mucosa. Children born with EB are called Butterfly Children, because their skin is as fragile as the wings of a butterfly. Presently, the disease has no cure. In

  18. Follicular non-Hodgkin's lymphoma with refractory paraneoplastic pemphigus : Case report with review of novel treatment modalities

    NARCIS (Netherlands)

    Van Rossum, MM; Verhaegen, NTM; Jonkman, MF; Mackenzie, MA; Koster, A; Van der Valk, PGM; Span, LFR

    2004-01-01

    In this paper a patient with a non-Hodgkin's lymphoma (NHL) and paraneoplastic pemphigus (PNP) is described. PNP is a very rare, painful mucocutaneous intraepithelial blistering disease associated with occult or confirmed malignancy. Patients with PNP show severe, progressive mucocutaneous disease

  19. Welfare of organic laying hens kept at different indoor stocking densities in a multi-tier aviary system. II: live weight, health measures and perching

    DEFF Research Database (Denmark)

    Steenfeldt, Sanna; Nielsen, Birte L.

    2015-01-01

    regulations on the keeping of organic laying hens. Hen live weight, mortality and foot health were not affected by the stocking densities used in the present study. Other variables (plumage condition, presence of breast redness and blisters, pecked tail feathers, and perch use) were indirectly affected...

  20. Dielectric Coating Thermal Stabilization During GaAs-Based Laser Fabrication for Improved Device Yield

    Science.gov (United States)

    2015-11-25

    forced outgassing of LT-PECVD SiO2 has been employed to reduce contact-metal blister formation in the fabrication of SiO2/Pt/ PZT /Pt capacitors. 10...modest thermal-stress-induced swing and minimal permanent change in coating stress. Differences in thermal-expansion coefficient between the

  1. Silvicultural approaches for management of eastern white pine to minimize impacts of damaging agents

    Science.gov (United States)

    M.E. Ostry; G. Laflamme; S.A. Katovich

    2010-01-01

    Since the arrival to North America of Cronartium ribicola, management of eastern white pine has been driven by the need to avoid the actual or, in many areas, the perceived damage caused by white pine blister rust. Although white pine has lost much of its former dominance, it remains a valuable species for biotic diversity, aesthetics, wildlife...

  2. Burns (For Parents)

    Science.gov (United States)

    ... small, and have sensitive skin that needs extra protection. Although some minor burns aren't cause for concern and can ... burns, the mildest of the three, are limited to the top layer of skin: Signs ... pain, and minor swelling. The skin is dry without blisters. Healing ...

  3. Range-wide conservation of Pinus aristata: A genetic collection with ecological context for proactive management today and resources for tomorrow

    Science.gov (United States)

    Anna W. Schoettle; Jonathan C. Coop

    2017-01-01

    Tree species are highly vulnerable to anthropogenic environmental change, and are increasingly being challenged by non-native pests and climate change. Rocky Mountain bristlecone pines are long-lived, exhibit delayed maturation, have low genetic diversity, and inhabit cold, high-elevation environments. They are threatened by the non-native disease white pine blister...

  4. Contribution to the study of zinc and cadmium diffusions in InP and In0,97 Ga0,03 As0,08 P0,92 quaternary compound

    International Nuclear Information System (INIS)

    Tesser Junior, N.L.

    1986-01-01

    The zinc and cadmium diffusions in In 0,97 Ga 0,03 As 0,08 P 0,92 and InP, using sealed blister method, are studied. The consequences of fick law in diffusion processes are analysed. The diffusion measuring methods and carried out adjustments are described. (M.C.K.) [pt

  5. Somatic mosaicism for the COL7A1 mutation p.Gly2034Arg in the unaffected mother of a patient with dystrophic epidermolysis bullosa pruriginosa

    NARCIS (Netherlands)

    van den Akker, P. C.; Pasmooij, A. M. G.; Meijer, R.; Scheffer, H.; Jonkman, M. F.

    Dystrophic epidermolysis bullosa (DEB) is a heritable blistering disorder caused by mutations in the type VII collagen gene, COL7A1. Although revertant mosaicism is well known in DEB, 'forward' somatic mosaicism, in which a pathogenic mutation arises on a wild-type (WT) background, extending beyond

  6. Somatic mosaicism for the COL7A1 mutation p.Gly2034Arg in the unaffected mother of a patient with dystrophic epidermolysis bullosa pruriginosa

    NARCIS (Netherlands)

    Akker, P.C. van den; Pasmooij, A.M.; Meijer, R.; Scheffer, H.; Jonkman, M.F.

    2015-01-01

    Dystrophic epidermolysis bullosa (DEB) is a heritable blistering disorder caused by mutations in the type VII collagen gene, COL7A1. Although revertant mosaicism is well known in DEB, 'forward' somatic mosaicism, in which a pathogenic mutation arises on a wild-type (WT) background, extending beyond

  7. 7 CFR 51.1319 - Injury.

    Science.gov (United States)

    2010-01-01

    ... FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) United States... or stimulated by artificial means; leaf whips or light limbrubs which resemble and blend into... color of the fruit has been materially changed, or if the skin is blistered or cracked, or the flesh...

  8. Long-term follow-up of patients with Herlitz-type junctional epidermolysis bullosa

    NARCIS (Netherlands)

    Yuen, W. Y.; Duipmans, J. C.; Molenbuur, B.; Herpertz, I.; Mandema, J. M.; Jonkman, M. F.

    Background Junctional epidermolysis bullosa, type Herlitz (JEB-H) is a rare, autosomal recessive disease caused by absence of the epidermal basement membrane adhesion protein laminin-332. It is characterized by extensive and devastating blistering of the skin and mucous membranes, leading to death

  9. Manzinellaforgiftning kompliceret med streptokokpharyngitis og impetigo

    DEFF Research Database (Denmark)

    Bygbjerg, Ib Christian; Johansen, H K

    1991-01-01

    A Danish tourist to Antigua in the West Indies, ate a fruit of Hippomane mancinella and developed acute poisoning with blistering of the oral mucosa and diarrhoea and a streptococcal superinfection. Ignorant tourists and their travel advisers are warned against this potentially deadly apple-tree-...

  10. A holistic approach to genetic conservation of Pinus strobiformis

    Science.gov (United States)

    K.M. Waring; R. Sniezko; B.A. Goodrich; C. Wehenkel; J.J. Jacobs

    2017-01-01

    Pinus strobiformis (southwestern white pine) is threatened by both a rapidly changing climate and the tree disease white pine blister rust, caused by an introduced fungal pathogen, Cronartium ribicola. We began a proactive program in ~2009 to sustain P. strobiformis that includes genetic conservation, research, and management strategies. Research...

  11. Kindler′s syndrome: A rare case report

    Directory of Open Access Journals (Sweden)

    Neelam Suman

    2014-01-01

    Full Text Available Kindler syndrome is a rare hereditary disorder, associated with skin fragility. The syndrome involves the skin and mucous membrane with radiological changes. The genetic defect has been identified on the short arm of chromosome 20. This report describes a 16-year-old patient with classical features like blistering and photosensitivity in childhood and the subsequent development of poikiloderma.

  12. Possibilities of radioisotopic fluorescence analysis application in copper industry

    International Nuclear Information System (INIS)

    Parus, J.; Kierzek, J.

    1983-01-01

    The main applications of X-ray fluorescence analysis in copper industry such as: copper ores and other materials from flotation analysis, lead and silver determination in blister copper, analysis of metallurgic dusts and copper base alloys analysis are presented. (A.S.)

  13. 62 case report hepatitis c virus-associated porphyria cutanea tarda

    African Journals Online (AJOL)

    boaz

    Porhyria cutanea tarda (PCT) is a rare, inherited or acquired disorder due to decreased activity or deficiency of uroporphyrinogen decarboxylase (UROD), one of the enzymes in the haem synthetic pathway. It is characterized by cutaneous manifestations such as erosions, blisters and bulae in the dorsum of the hand, ...

  14. Improved nickel plating of Inconel X-750

    Science.gov (United States)

    Farmer, M. E.; Feeney, J. E.; Kuster, C. A.

    1969-01-01

    Electroplating technique with acid pickling provides a method of applying nickel plating on Inconel X-750 tubing to serve as a wetting agent during brazing. Low-stress nickel-plating bath contains no organic wetting agents that cause the nickel to blister at high temperatures.

  15. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

    LENUS (Irish Health Repository)

    McCormack, Mark

    2011-03-24

    Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.

  16. The main problems of parents of a child with epidermolysis bullosa

    NARCIS (Netherlands)

    van Scheppingen, Corinne; Lettinga, Ant T.; Duipmans, Jose C.; Maathuis, Karel G. B.; Jonkman, Marcel F.

    Epidermolysis Bullosa (EB) is a rare genetic blistering- skin disorder with varying degrees of severity, ranging from mild forms to severe forms, with chronic progression. The aim of this study was to identify and specify the problems of parents of a child with EB. Qualitative research methodology

  17. Expedition medicine: A southern African perspective | Hofmeyr ...

    African Journals Online (AJOL)

    Routine general practice complaints and accidental trauma are ubiquitous; travel medical issues such as blisters, diarrhoea, insomnia, sunburn and dehydration occur commonly; area/activity-specific issues such as infectious disease risks and altitude illnesses must be addressed; and women's health and dental problems ...

  18. Primary hemochromatosis presented by porphyria cutanea tarda: a case report.

    NARCIS (Netherlands)

    Bovenschen, H.J.; Vissers, W.H.P.M.

    2009-01-01

    We present a 27-year-old female Caucasian patient, who initially presented with extensive fragility and blistering of mainly the dorsal side of both hands. Histology and urine porphyrin analysis confirmed the diagnosis of porphyria cutanea tarda. Internal screening for underlying disease revealed

  19. The Higgs Boson: Is the End in Sight?

    Science.gov (United States)

    Lincoln, Don

    2012-01-01

    This summer, perhaps while you were lounging around the pool in the blistering heat, the blogosphere was buzzing about data taken at the Large Hadron Collider at CERN. The buzz reached a crescendo in the first week of July when both Fermilab and CERN announced the results of their searches for the Higgs boson. Hard data confronted a theory nearly…

  20. Mouth ulcers

    Science.gov (United States)

    ... Gingivostomatitis Herpes simplex ( fever blister ) Leukoplakia Oral cancer Oral lichen planus Oral thrush A skin sore caused by histoplasmosis may ... mouth Images Oral thrush Canker sore (aphthous ulcer) Lichen planus on the oral mucosa Mouth sores References Daniels TE, Jordan RC. ...

  1. Strategies, tools, and challenges for sustaining and restoring high elevation five-needle white pine forests in western North America

    Science.gov (United States)

    Robert E. Keane; Anna W. Schoettle

    2011-01-01

    Many ecologically important, five-needle white pine forests that historically dominated the high elevation landscapes of western North America are now being heavily impacted by mountain pine beetle (Dendroctonus spp.) outbreaks, the exotic disease white pine blister rust (WPBR), and altered high elevation fire regimes. Management intervention using specially designed...

  2. Mouth sores

    Science.gov (United States)

    ... To help cold sores or fever blisters, you can also apply ice to the sore. You may reduce your chance of getting common mouth sores by: Avoiding very hot foods or beverages Reducing stress and practicing relaxation techniques like yoga or meditation ...

  3. Phylogeny of an Albugo sp. infecting Barbarea vulgaris in Denmark and its frequency of symptom development in natural populations of two evolutionary divergent plant types

    DEFF Research Database (Denmark)

    van Mölken, Tamara; Heimes, Christine; Hauser, Thure Pavlo

    2014-01-01

    The oomycete Albugo candida has long been considered a broad spectrum generalist pathogen, but recent studies suggest that it is diverged into several more specialised species in addition to the generalist Albugo candida s.s.. Whereas these species cause the disease white blister rust in many cru...

  4. Recessive Epidermolysis Bullosa simplex- A case report

    African Journals Online (AJOL)

    Ademu

    Abstract: Background:Epidermolysis bullosa simplex (EBS) is characterized by intraepidermal blister formation, most commonly appearing in early infancy. Many variants of EBS exist; the four most common variants are inherited in an autosomal dominant fashion. The recessive forms are rare and less reported in our ...

  5. Punch grafting of chronic ulcers in patients with laminin-332-deficient, non-Herlitz junctional epidermolysis bullosa

    NARCIS (Netherlands)

    Yuen, Wing Yan; Huizinga, Janneke; Jonkman, Marcel F.

    Background: Epidermolysis bullosa (EB) is a genetic, heterogeneous, trauma-induced blistering disease. Patients with laminin-332-deficient non-Herlitz junctional EB (JEB-nH) can have impaired wound healing witnessed by persistent, small, deep ulcers on the hands and feet that adversely affect the

  6. Landscape biology of western white pine: implications for conservation of a widely-distributed five-needle pine at its southern range limit

    Science.gov (United States)

    Patricia Maloney; Andrew Eckert; Detlev Vogler; Camille Jensen; Annette Delfino Mix; David Neale

    2016-01-01

    Throughout much of the range of western white pine, Pinus monticola Dougl., timber harvesting, fire exclusion and the presence of Cronartium ribicola J. C. Fisch., the white pine blister rust (WPBR) pathogen, have led to negative population and genetic consequences. To address these interactions, we examined population dynamics...

  7. Preparation and properties of hydrothermally stable gamma-alumina membranes

    NARCIS (Netherlands)

    Nijmeijer, Arian; Kruidhof, H.; Bredesen, Rune; Verweij, H.

    2001-01-01

    Supported mesoporous γ-Al2O3 membranes deteriorate and blister in steam-containing environments at high temperatures. This deterioration led us to the development of a new type of supported γ-Al2O3 membrane with significantly improved stability under hostile conditions. Two measures were taken to

  8. Sexually Transmitted Infection

    Science.gov (United States)

    ... infected person’s herpes sore or fluid from a herpes sore. Having genital herpes during pregnancy can cause serious health problems for ... pass herpes to your baby if you have genital herpes sores and blisters (called an outbreak) for the ...

  9. 76 FR 42631 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List Pinus...

    Science.gov (United States)

    2011-07-19

    ... typically 5 to 20 meters (m) (16 to 66 feet (ft)) tall with a rounded or irregularly spreading crown shape... disease white pine blister rust and the current epidemic of the predatory mountain pine beetle... warming trends have resulted in unprecedented mountain pine beetle epidemics throughout the range of P...

  10. Foot-and-Mouth Disease

    DEFF Research Database (Denmark)

    Belsham, Graham; Charleston, Bryan; Jackson, Terry

    2015-01-01

    Foot‐and‐mouth disease (FMD) is an economically important, highly contagious disease of cloven‐hoofed animals characterised by the appearance of vesicles (blisters) on the feet and in, and around, the mouth. The causative agent, foot‐and‐mouth disease virus (FMDV), was the first mammalian virus...

  11. Caloplaca alstrupii, a new lichen species from Denmark

    DEFF Research Database (Denmark)

    Søchting, Ulrik

    1999-01-01

    Caloplaca alstrupii Søchting is described from an old Platanus in Denmark. The sorediate species has a greyish smooth thallus with very characteristic globose to subglobose blister-like areoles that rupture at maturity exposing pale yellowish green soredia. Apothecia sparse, orange, differing fro...... those of the other species having soralia without anthraquinones....

  12. Foot-and-mouth disease

    DEFF Research Database (Denmark)

    Belsham, Graham; Charleston, Bryan; Jackson, Terry

    2009-01-01

    Foot-and-mouth disease is an economically important, highly contagious, disease of cloven-hoofed animals characterized by the appearance of vesicles (blisters) on the feet and in and around the mouth. The causative agent, foot-and-mouth disease virus, was the first mammalian virus to be discovered...

  13. Semi-continuous high speed gas analysis of generated vapors of chemical warfare agents

    NARCIS (Netherlands)

    Trap, H.C.; Langenberg, J.P.

    1999-01-01

    A method is presented for the continuous analysis of generated vapors of the nerve agents soman and satin and the blistering agent sulfur mustard. By using a gas sampling valve and a very short (15 cm) column connected to an on-column injector with a 'standard length' column, the system can either

  14. Rust resistance in seedling families of Pinus albicaulis and Pinus strobiformis and implications for restoration

    Science.gov (United States)

    R. A. Sniezko; A. Kegley; R. Danchok; J. Hamlin; J. Hill; D. Conklin

    2011-01-01

    Infection and mortality levels from Cronartium ribicola, the fungus causing white pine blister rust, are very high in parts of the geographic range of Pinus albicaulis (whitebark pine) and P. strobiformis (Southwestern white pine). Genetic resistance to this non-native fungus will be one of the key factors in maintaining or restoring populations of these species in...

  15. A 20-year reassessment of the health and status of whitebark pine forests in the Bob Marshall Wilderness Complex, Montana

    Science.gov (United States)

    Molly L. Retzlaff; Signe B. Leirfallom; Robert E. Keane

    2016-01-01

    Whitebark pine plays a prominent role in high elevation ecosystems of the northern Rocky Mountains. It is an important food source for many birds and mammals as well as an essential component of watershed stabilization. Whitebark pine is vanishing from the landscape due to three main factors: white pine blister rust, mountain pine beetle outbreaks, and successional...

  16. Natural regeneration of whitebark pine: Factors affecting seedling density

    Science.gov (United States)

    S. Goeking; D. Izlar

    2014-01-01

    Whitebark pine (Pinus albicaulis) is an ecologically important species in high-altitude areas of the western United States and Canada due to the habitat and food source it provides for Clark’s nutcrackers, red squirrels, grizzly bears, and other animals. Whitebark pine stands have recently experienced high mortality due to wildfire, white pine blister rust, and a...

  17. Influence of epidermal hydration on the friction of human skin against textiles

    OpenAIRE

    Gerhardt, L.-C; Strässle, V; Lenz, A; Spencer, N.D; Derler, S

    2008-01-01

    Friction and shear forces, as well as moisture between the human skin and textiles are critical factors in the formation of skin injuries such as blisters, abrasions and decubitus. This study investigated how epidermal hydration affects the friction between skin and textiles.

  18. Influence of epidermal hydration on the friction of human skin against textile

    NARCIS (Netherlands)

    Gerhardt, L.C.; Strässle, V.; Lenz, A.; Spencer, N.D.; Derler, S.

    2008-01-01

    Friction and shear forces, as well as moisture between the human skin and textiles are critical factors in the formation of skin injuries such as blisters, abrasions and decubitus. This study investigated how epidermal hydration affects the friction between skin and textiles. The friction between

  19. Fire Ant Allergy

    Science.gov (United States)

    ... venom in a fire ant sting will kill bacteria and some of your skin cells. This results in the formation of a blister that fills with a cloudy white material in about 24 hours. While this looks like a pus-filled lesion that should be drained, ...

  20. Interaction of implanted deuterium and helium with beryllium: radiation enhanced oxidation

    International Nuclear Information System (INIS)

    Langley, R.A.

    1979-01-01

    The interaction of implanted deuterium and helium with beryllium is of significant interest in the application of first wall coatings and other components of fusion reactors. Electropolished polycrystalline beryllium was first implanted with an Xe backscatter marker at 1.98 MeV followed by either implantation with 5 keV diatomic deuterium or helium. A 2.0 MeV He beam was used to analyze for impurity buildup; namely oxygen. The oxide layer thickness was found to increase linearly with increasing implant fluence. A 2.5 MeV H + beam was used to depth profile the D and He by ion backscattering. In addition the retention of the implant was measured as a function of the implant fluence. The mean depth of the implant was found to agree with theoretical range calculations. Scanning electron microscopy was used to observe blister formation. No blisters were observed for implanted D but for implanted He blisters occurred at approx. 1.75 x 10 17 He cm -2 . The blister diameter increased with increasing implant fluence from about 0.8 μm at 10 18 He cm -2 to 5.5 μm at 3 x 10 18 He cm -2

  1. 21 CFR 558.415 - Novobiocin.

    Science.gov (United States)

    2010-04-01

    ... susceptible to novobiocin; treatment of acute outbreaks of fowl cholera caused by strains of Pasteurella... lb. body weight per day. (a) Indications for use. Aid in the treatment of breast blisters associated.... body weight per day. (a) Indications for use. Treatment of staphylococcal synovitis and generalized...

  2. Stopping Shingles (A Minute of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2018-01-25

    Shingles, also known as herpes zoster, is a disease characterized by a painful skin rash with blisters. This podcast discusses a new vaccine to prevent shingles.  Created: 1/25/2018 by MMWR.   Date Released: 1/25/2018.

  3. Provenance study through analysis of microstructural characteristics using an optical microscope and scanning electron microscopy for Goryeo celadon excavated from the seabed.

    Science.gov (United States)

    Min-su, Han

    2013-08-01

    This paper aims at identifying the provenance of Goryeo celadons by understanding its microstructural characteristics, such as particles, blisters, forms and amount of pores, and the presence of crystal formation, bodies, and glazes and its boundary, using an optical microscope and scanning electron microscopy (SEM). The analysis of the reproduced samples shows that the glazed layer of the sherd fired at higher temperatures has lower viscosity and therefore it encourages the blisters to be combined together and the layer to become more transparent. In addition, the result showed that the vitrification and melting process of clay minerals such as feldspars and quartzs on the bodies was accelerated for those samples. To factor such characteristics of the microstructure and apply it to the sherds, the samples could be divided into six categories based on status, such as small particles with many small pores or mainly large and small circular pores in the bodies, only a limited number of varied sized blisters in the glazes, and a few blisters and needle-shaped crystals on the boundary surface. In conclusion, the analysis of the microstructural characteristics using an optical microscope and SEM have proven to be useful as a categorizing reference factor in a provenance study on Goryeo celadons.

  4. Developing proactive management options to sustain bristlecone and limber pine ecosystems in the presence of a non-native pathogen

    Science.gov (United States)

    A. W. Schoettle

    2004-01-01

    Limber pine and Rocky Mountain bristlecone pine are currently threatened by the non-native pathogen white pine blister rust (WPBR). Limber pine is experiencing mortality in the Northern Rocky Mountains and the infection front continues to move southward. The first report of WPBR on Rocky Mountain bristlecone pine was made in 2003 (Blodgett and Sullivan 2004), at a site...

  5. Molecular dissection of white pine genetic resistance to Cronartium ribicola

    Science.gov (United States)

    Jun-Jun Liu; Richard Sniezko

    2011-01-01

    Pinus monticola (Dougl. ex D. Don.) maintains a complex defence system that detects white pine blister rust pathogen (Cronartium ribicola J.C.Fisch.) and activates resistance responses. A thorough understanding of how it functions at the molecular level would provide us new strategies for creating forest trees with durable disease resistance. Our research focuses on...

  6. Molecular and genetic basis for partial resistance of western white pine against Cronartium ribicola.

    Science.gov (United States)

    Jun-Jun Liu; Arezoo Zamany; Richard. Sniezko

    2012-01-01

    Western white pine (Pinus monticola Douglas ex D. Don) is an important forest species in North America. Forest genetics programs have been breeding for durable genetic resistance against white pine blister rust (WPBR) caused by Cronartium ribicola in the past few decades. As various genetic resistance resources are screened and...

  7. 19 CFR 10.539 - Retail packaging materials and containers.

    Science.gov (United States)

    2010-04-01

    ...-Singapore Free Trade Agreement Rules of Origin § 10.539 Retail packaging materials and containers. Packaging... requirement. The United States importer of good C decides to use the build-down method, RVC=((AV−VNM)/AV... content requirement. In applying this method, the non-originating blister packages are taken into account...

  8. Novel TGM5 mutations in acral peeling skin syndrome

    NARCIS (Netherlands)

    van der Velden, Jaap J. A. J.; van Geel, Michel; Nellen, Ruud G. L.; Jonkman, Marcel F.; McGrath, John A.; Nanda, Arti; Sprecher, Eli; van Steensel, Maurice A. M.; McLean, W. H. Irwin; Cassidy, Andrew J.

    Acral peeling skin syndrome (APSS, MIM #609796) is a rare autosomal recessive disorder characterized by superficial exfoliation and blistering of the volar and dorsal aspects of hands and feet. The level of separation is at the junction of the stratum granulosum and stratum corneum. APSS is caused

  9. Keratolysis exfoliativa (dyshidrosis lamellosa sicca): a distinct peeling entity

    NARCIS (Netherlands)

    Chang, Y.Y.; Velden, J. van der; van der Wier, G.; Kramer, D.; Diercks, G.F.; van Geel, M.; Coenraads, P.J.; Zeeuwen, P.L.J.M.; Jonkman, M.F.

    2012-01-01

    Background Keratolysis exfoliativa (KE), also known as dyshidrosis lamellosa sicca, is a palmoplantar dermatosis characterized by air-filled blisters and collarette desquamation. It has been regarded as a subtype of dyshidrotic eczema, a fungal infection or a dermatophytid reaction. KE may also

  10. Keratolysis exfoliativa (dyshidrosis lamellosa sicca) : a distinct peeling entity

    NARCIS (Netherlands)

    van der Velden, J.; van der Wier, G.; Kramer, D.; Diercks, G.F.; van Geel, M.; Coenraads, P.J.; Zeeuwen, P.L.; Jonkman, M.F.; Chang, Y.Y.

    Background Keratolysis exfoliativa (KE), also known as dyshidrosis lamellosa sicca, is a palmoplantar dermatosis characterized by air-filled blisters and collarette desquamation. It has been regarded as a subtype of dyshidrotic eczema, a fungal infection or a dermatophytid reaction. KE may also

  11. Threats, status & management options for bristlecone pines and limber pines in Southern Rockies

    Science.gov (United States)

    A. W. Schoettle; K. S. Burns; F. Freeman; R. A. Sniezko

    2006-01-01

    High-elevation white pines define the most remote alpine-forest ecotones in western North America yet they are not beyond the reach of a lethal non-native pathogen. The pathogen (Cronartium ribicola), a native to Asia, causes the disease white pine blister rust (WPBR) and was introduced into western Canada in 1910. Whitebark (Pinus albicaulis) and...

  12. Jejunal perforation by swallowed ibuprofen caplet | Njoku | Nigerian ...

    African Journals Online (AJOL)

    We present a case of jejunal perforation caused by an unusual foreign body, an ibuprofen caplet in its blister packing believed to be the first of its kind, perforation of the intestine caused by an ingested medication. The patient eventually developed an enterocutaneous fistula through the weak wall of a preexisting incisional ...

  13. Antisense Oligonucleotide-mediated Exon Skipping as a Systemic Therapeutic Approach for Recessive Dystrophic Epidermolysis Bullosa : Exon Skipping as Systemic Therapy for RDEB

    NARCIS (Netherlands)

    Bremer, Jeroen; Bornert, Olivier; Nyström, Alexander; Gostynski, Antoni; Jonkman, Marcel F; Aartsma-Rus, Annemieke; van den Akker, Peter C; Pasmooij, Anna MG

    2016-01-01

    The "generalized severe" form of recessive dystrophic epidermolysis bullosa (RDEB-gen sev) is caused by bi-allelic null mutations in COL7A1, encoding type VII collagen. The absence of type VII collagen leads to blistering of the skin and mucous membranes upon the slightest trauma. Because most

  14. Characterisation of the clinical and activated T cell response to repeat delayed-type hypersensitivity skin challenges in human subjects, with KLH and PPD, as a potential model to test T cell-targeted therapies.

    Science.gov (United States)

    Belson, Alexandra; Schmidt, Tim; Fernando, Disala; Hardes, Kelly; Scott, Nicola; Brett, Sara; Clark, Deborah; Oliveira, João Joaquim; Davis, Bill; McHugh, Simon; Stone, John

    2016-05-01

    To characterise the delayed-type hypersensitivity (DTH) skin reaction to repeated challenges of keyhole limpet hemocyanin (KLH) and tuberculin purified protein derivative (PPD) in healthy volunteers, as a potential model to test T cell-targeted investigational agents. Forty-nine subjects received either KLH, PPD, or PBS repeat skin challenges, and clinical assessments including induration, erythema and Laser Doppler Imaging. Skin biopsies or suction blisters were taken after challenge to investigate the cellular infiltrate of the challenge site, the T cell activation status, as determined by LAG-3 expression, and, specifically for the blister, the concentrations of inflammatory cytokines. Point estimates, estimates of variation and corresponding 95% confidence intervals were constructed for each type of challenge and timepoint. The DTH response could be measured at 48 and 120 h post-KLH and PPD challenge with induration, erythema and Laser Doppler Imaging, with 48 h post-challenge demonstrating the peak of the response. PPD was well tolerated in subjects after multiple challenges, however, a significant number of KLH-treated subjects demonstrated an injection site reaction 6-7 days following the SC injection. PPD demonstrated a boost effect on the second challenge as measured by increased induration, where as this was not noted consistently for KLH. Compared to unchallenged and PBS control-injected skin, increased T cell numbers were detected in the challenge site by both the skin suction blister and biopsy technique, at either time point following KLH or PPD challenge. Use of the T cell activation marker LAG-3 demonstrated the activated phenotype of these cells. In skin blisters, higher numbers of LAG-3+ T cells were detected at 48 h post-challenge, whereas in the biopsies, similar numbers of LAG-3+ cells were observed at both 48 and 120 h. Analysis of blister T cell subpopulations revealed some differences in phenotypes between the time points and between the CD4

  15. Surface damage and gas trapping profile measurements in copper during 20 kev He+ irradiation

    International Nuclear Information System (INIS)

    Terreault, B.; Veilleux, G.

    1980-01-01

    Surface damage due to 20 keV he + irradiation of OFHC Cu was studied by optical and scanning electron microscopy, and by gas trapping profile measurements with proton backscattering and elastic recoil detection. Both annealed (1 h at 773 K) and unannealed Cu were implanted, at 300 K (0.22Tsub(m)) and 500 K(0.37 Tsub(m)), up to fluences of 3 x 10 18 cm -2 . Additional results with thin (1 μm) evaporated films and stressed cold-rolled foils (3 μm) were obtained. At 500 K in bulk OFHC Cu pores and/or large (approx. 1μm) but scattered blisters appear; at 300 K in bulk or thin film Cu blisters are large and abundant. In all these cases a very large (>=1.5 x 10 1 7 cm -2 ) and sudden release of deeply implanted helium takes place, leading to a depleted profile at a depth of about 90 nm (approx. Rsub(p)). In contrast in cold-rolled foils the blisters are small (approx. 0.4 μm) and the profiles are undepleted. These results are explained by fissuration of helium-pressurized cavities. At high fluence blisters disappear, leaving a porous structure at 500 K and a rough micro-relief at 300 K; the helim profiles are flat and very wide (2-3 Rsub(p)). Blister disappearance, absence of flaking, and porous structure are discussed in terms of the width of the profiles and the formation of a helium-saturated, highly damaged (recrystallized), and permeable layer. (orig.)

  16. The Influence of Irradiation Regimes on Retention Hydrogen Isotopes in Structural Materials

    International Nuclear Information System (INIS)

    Zaluzhnyi, A.

    2007-01-01

    Full text of publication follows: In the present work was investigated the influence of irradiation regimes on retention hydrogen isotopes in samples of austenitic steel during heating. The samples of studied materials were irradiated both in the reactor and by hydrogen isotopes ions of different energies and fluencies bombardment in an accelerator. Kinetic of hydrogen release from the samples worked with deuterium plasma was investigated. The following results were obtained. Heating the irradiate d samples of steel (irradiated in the reactor or by hydrogen isotopes ions bombardment), which have been kept in normal temperature during quite a long period after the irradiation, a shift of the diffusion peak of hydrogen release to higher temperatures, comparing to no irradiated samples, was observed. It means that atoms of hydrogen in the irradiated sample were caught by radiation defects, which are very effective as traps for hydrogen atoms till quite high temperatures (700 K). The worked out analysis of the received results supposes that vacancy complexes. On thermodesorption curves of hydrogen release from irradiated samples of austenitic steels a high temperature peak (900-1000 K) was observed because of dissociation of hydrogen containing compounds in micro pores. During investigations of hydrogen release from irradiated samples of austenitic steel, after it had been saturated with hydrogen plasma, abnormally big blisters were registered with cover thickness of about 1 mkm. Three peaks were observed on the thermodesorption curves of hydrogen release from irradiated samples, contained blisters. The low temperature spike (∼500 K) was showed to correspond to hydrogen release because of its resolution from blisters, where it was in molecular form. The high temperature peak (∼900 K) corresponds to hydrogen release from dissociating blisters, which contain hydrocarbons. The mechanism of abnormal blisters generation is offered. Inasmuch methane is not soluble in

  17. Origin of microplasma instabilities during DC operation of silicon based microhollow cathode devices

    Science.gov (United States)

    Felix, Valentin; Lefaucheux, Philippe; Aubry, Olivier; Golda, Judith; Schulz-von der Gathen, Volker; Overzet, Lawrence J.; Dussart, Rémi

    2016-04-01

    The failure mechanisms of micro hollow cathode discharges (MHCD) in silicon have been investigated using their I-V characteristics, high speed photography and scanning electron microscopy. Experiments were carried out in helium. We observed I-V instabilities in the form of rapid voltage decreases associated with current spikes. The current spikes can reach values more than 100 times greater than the average MHCD current. (The peaks can be more than 1 Ampere for a few 10’s of nanoseconds.) These current spikes are correlated in time with 3-10 μm diameter optical flashes that occur inside the cavities. The SEM characterizations indicated that blister-like structures form on the Si surface during plasma operation. Thin Si layers detach from the surface in localized regions. We theorize that shallow helium implantation occurs and forms the ‘blisters’ whenever the Si is biased as the cathode. These blisters ‘explode’ when the helium pressure inside them becomes too large leading to the transient micro-arcs seen in both the optical emission and the I-V characteristics. We noted that blisters were never found on the metal counter electrode, even when it was biased as the cathode (and the Si as the anode). This observation led to a few suggestions for delaying the failure of Si MHCDs. One may coat the Si cathode (cavities) with blister resistant material; design the MHCD array to operate with the Si as the anode rather than as the cathode; or use a gas additive to prevent surface damage. Regarding the latter, tests using SF6 as the gas additive successfully prevented blister formation through rapid etching. The result was an enhanced MHCD lifetime.

  18. Origin of microplasma instabilities during DC operation of silicon based microhollow cathode devices

    International Nuclear Information System (INIS)

    Felix, Valentin; Lefaucheux, Philippe; Aubry, Olivier; Dussart, Rémi; Golda, Judith; Schulz-von der Gathen, Volker; Overzet, Lawrence J

    2016-01-01

    The failure mechanisms of micro hollow cathode discharges (MHCD) in silicon have been investigated using their I-V characteristics, high speed photography and scanning electron microscopy. Experiments were carried out in helium. We observed I–V instabilities in the form of rapid voltage decreases associated with current spikes. The current spikes can reach values more than 100 times greater than the average MHCD current. (The peaks can be more than 1 Ampere for a few 10’s of nanoseconds.) These current spikes are correlated in time with 3–10 μm diameter optical flashes that occur inside the cavities. The SEM characterizations indicated that blister-like structures form on the Si surface during plasma operation. Thin Si layers detach from the surface in localized regions. We theorize that shallow helium implantation occurs and forms the ‘blisters’ whenever the Si is biased as the cathode. These blisters ‘explode’ when the helium pressure inside them becomes too large leading to the transient micro-arcs seen in both the optical emission and the I–V characteristics. We noted that blisters were never found on the metal counter electrode, even when it was biased as the cathode (and the Si as the anode). This observation led to a few suggestions for delaying the failure of Si MHCDs. One may coat the Si cathode (cavities) with blister resistant material; design the MHCD array to operate with the Si as the anode rather than as the cathode; or use a gas additive to prevent surface damage. Regarding the latter, tests using SF 6 as the gas additive successfully prevented blister formation through rapid etching. The result was an enhanced MHCD lifetime. (paper)

  19. Parent artery occlusion for ruptured "true" posterior communicating artery aneurysm.

    Science.gov (United States)

    Mitsuhashi, Takashi; Takeda, Nobuaki; Oishi, Hidenori; Arai, Hajime

    2015-04-01

    A case of a patient with a ruptured true posterior communicating artery (PCoA) aneurysm is reported, who had been managed by early endovascular parent artery occlusion with coils. The small blister aneurysm was located at the proximal PCoA itself and directed superiorly. Postoperative course was uneventful. During 1-month follow-up, the patient recovered well and could care for herself. Aneurysms of the PCoA itself are very rare. As reported to date, surgical procedures would favor microsurgical clipping over endovascular coil embolization. Endovascular treatment may be a good alternative to surgical trapping for true PCoA blister aneurysm. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  20. Effect of smoking, abstention, and nicotine patch on epidermal healing and collagenase in skin transudate

    DEFF Research Database (Denmark)

    Sorensen, L.T.; Zillmer, R.; Agren, M.

    2009-01-01

    Delayed wound healing may explain postoperative tissue and wound dehiscence in smokers, but the effects of smoking and smoking cessation on the cellular mechanisms remain unclear. Suction blisters were raised in 48 smokers and 30 never smokers. The fluid was retrieved and the epidermal roof...... and in 6 never smokers. Matrix metalloproteinase (MMP)-8 and MMP-1 levels in suction blister fluid were assessed by an enzyme-linked immunosorbent assay. Random-effects models for repeated measurements were applied and p ....47-19.92) g/cm(2) hour (mean, 95% CI) in smokers and 13.89 (9.46-18.33) in never smokers (p smokers TEWL was 18.95 (15.20-22.70)(p smokers). In smokers, MMP-8 was 36.4 (24.3-48.5) ng/mL (mean, 95% CI) and 15.2 (1.4-30.2) ng/mL in never smokers (p

  1. Tensin stabilizes integrin adhesive contacts in Drosophila.

    Science.gov (United States)

    Torgler, Catherine N; Narasimha, Maithreyi; Knox, Andrea L; Zervas, Christos G; Vernon, Matthew C; Brown, Nicholas H

    2004-03-01

    We report the functional characterization of the Drosophila ortholog of tensin, a protein implicated in linking integrins to the cytoskeleton and signaling pathways. A tensin null was generated and is viable with wing blisters, a phenotype characteristic of loss of integrin adhesion. In tensin mutants, mechanical abrasion is required during wing expansion to cause wing blisters, suggesting that tensin strengthens integrin adhesion. The localization of tensin requires integrins, talin, and integrin-linked kinase. The N-terminal domain and C-terminal PTB domain of tensin provide essential recruitment signals. The intervening SH2 domain is not localized on its own. We suggest a model where tensin is recruited to sites of integrin adhesion via its PTB and N-terminal domains, localizing the SH2 domain so that it can interact with phosphotyrosine-containing proteins, which stabilize the integrin link to the cytoskeleton.

  2. Primary Copper Smelter and Refinery as a Recycling Plant—A System Integrated Approach to Estimate Secondary Raw Material Tolerance

    Directory of Open Access Journals (Sweden)

    Olof Forsén

    2017-10-01

    Full Text Available The primary production of sulfide concentrates includes smelting to copper matte or blister copper, conversion of matte to blister copper, and refining to copper. Smelting, converting, and fire-refining can use a limited amount of secondary materials. Molten copper can effectively dissolve many metals, from valuable noble metals to harmful impurities such as bismuth. However, some of the impurity metals in copper are valuable in other applications. In this paper, we outline the main material flows in copper smelting and electrorefining and describe how minor metals can be recovered from secondary raw materials using copper as a carrier material. We will use a system integrated approach to define the factors that affect the recovery of different metals and copper quality. Metals typical in copper production are used as examples, like noble metals, As, Bi, Se, and Te, including metals in the EU critical raw materials list like PGM and Sb.

  3. Dystrophic Epidermolysis Bullosa in Pregnancy: A Case Report of the Autosomal Dominant Subtype and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Nicole Colgrove

    2014-01-01

    Full Text Available Epidermolysis bullosa (EB is a group of inherited blistering skin diseases that vary widely in their pathogenesis and severity. There are three main categories of EB: simplex, junctional, and dystrophic. This classification is based on the level of tissue separation within the basement membrane zone and this is attributed to abnormalities of individual or several anchoring proteins that form the interlocking network spanning from the epidermis to the dermis underneath. Dystrophic EB results from mutations in COL7A1 gene coding for type VII collagen leading to blister formation within the dermis. Diagnosis ultimately depends on the patient’s specific genetic mutation, but initial diagnosis can be made from careful examination and history taking. We present a pregnant patient known to have autosomal dominant dystrophic EB and discuss the obstetrical and neonatal outcome. The paper also reviews the current English literature on this rare skin disorder.

  4. Emergency management of chemical weapons injuries.

    Science.gov (United States)

    Anderson, Peter D

    2012-02-01

    The potential for chemical weapons to be used in terrorism is a real possibility. Classes of chemical weapons include nerve agents, vesicants (blister agents), choking agents, incapacitating agents, riot control agents, blood agents, and toxic industrial chemicals. The nerve agents work by blocking the actions of acetylcholinesterase leading to a cholinergic syndrome. Nerve agents include sarin, tabun, VX, cyclosarin, and soman. The vesicants include sulfur mustard and lewisite. The vesicants produce blisters and also damage the upper airways. Choking agents include phosgene and chlorine gas. Choking agents cause pulmonary edema. Incapacitating agents include fentanyl and its derivatives and adamsite. Riot control agents include Mace and pepper spray. Blood agents include cyanide. The mechanism of toxicity for cyanide is blocking oxidative phosphorylation. Toxic industrial chemicals include agents such as formaldehyde, hydrofluoric acid, and ammonia.

  5. Nutritional support for children with epidermolysis bullosa.

    Science.gov (United States)

    Haynes, Lesley

    Epidermolysis bullosa (EB) comprises a rare group of genetically determined skin blistering disorders characterized by extreme fragility of the skin and mucous membranes, with recurrent blister formation. The cornerstones of management are control of infection, wound management, pain relief, promotion of optimal nutritional status and mobility, surgical intervention and provision of the best possible quality of life. There is currently no cure for EB and, throughout life, those with the more severe types are at risk of significant nutritional compromise which impacts negatively on health and overall quality of life. Nutritional support is an important facet of holistic care and the dietetic challenges can be considerable. This paper describes some of the issues involved in optimizing the nutritional status of children with this disorder.

  6. Neutron radiography of irradiated zircaloy coupons of pressure tubes from PHWR`s

    Energy Technology Data Exchange (ETDEWEB)

    Gangotra, S; Ouseph, P M; Tamhane, A B; Singh, H N; Sahoo, K C [Bhabha Atomic Research Centre, Bombay (India). Radiometallurgy Div.

    1994-12-31

    The Indian Pressurised Heavy Water Reactors (PHWR`s) are of CANDU type, consisting of 304 zircaloy-2 pressure tubes. These pressure tubes contain the fuel bundles, where the heat is generated and is removed by the heavy water flowing through these pressure tubes at high temperature and pressure. These pressure tubes are surrounded by the calandria tubes, and are separated from them by a pair of garter springs. Over a period of time, as a result of the irradiation creep and assisted by the displacement of the garter springs, the hot pressure tube may come in contact with the cold calandria tube. This would result in the hydrogen migrating to the cold contact location and formation of hydride blisters. These blisters could eventually rupture the pressure tube by the DHC (delayed hydrogen cracking) mechanism. 2 refs., 2 figs.

  7. Surface behaviour of first-wall materials due to the synergistic effect of helium and hydrogen isotopes

    International Nuclear Information System (INIS)

    Abramov, E.; Moreno, D.; Solovioff, G.; Eliezer, D.

    1994-01-01

    Scanning electron microscopy has been used to investigate changes in surface morphology due to helium implantation and hydrogen charging. Pure polycrystalline nickel, OFHC copper and Cu-1.8Be-0.2Co (CAD 172) alloy have been studied. The influence of helium implantation parameters on blister formation and growth was investigated. Hydrogen charging (cathodic or thermal-gas) was found to lower the helium content needed for blistering and surface exfoliation. The effect of heating, carried out after hydrogen charging, was also studied. For the copper samples, hydrogen damage was produced by oxide reduction at the oxide-metal interface. This damage was found to be lower when the sputtering due to helium implantation increased. The CuBe alloy showed a greater hydrogen resistance due to the stability of the surface BeO. ((orig.))

  8. Beam limiter for thermonuclear fusion devices

    International Nuclear Information System (INIS)

    Kaminsky, M.S.

    1976-01-01

    A beam limiter circumscribes the interior surface of a vacuum vessel to inhibit collisions of contained plasma and the vessel walls. The cross section of the material making up the limiter has a flatsided or slightly concave portion of increased width towards the plasma and portions of decreased width towards the interior surface of the vessel. This configuration is designed to prevent a major fraction of the material sputtered, vaporized and blistered from the limiter from reaching the plasma. It also allows adequate heat transfer from the wider to the narrower portions. The preferred materials for the beam limiter are solids of sintered, particulate materials of low atomic number with low vapor pressure and low sputtering and blistering yields. 7 claims, 3 figures

  9. The mechanical response of tetragonal zirconia polycrystal to conical indentation

    International Nuclear Information System (INIS)

    Asif, S.A.S.; Biswas, S.K.

    1994-01-01

    Blocks of 3Y-TZP were indented with conical diamond indenters. Indentation caused tetragonal to monoclinic phase transformation in a subsurface. Of the cracks generated in the subsurface, radial and lateral cracks can be accounted for by a continuum model of the indented subsurface, built using a combination of the Boussinesq and blister stress fields. Additional ring, median and cone cracks were also observed. It is hypothesized that the latter are motivated by the reduction in blister strength or residual energy brought about by the material damage caused by the phase transformation. This damage reduces the load bearing capacity of the material progressively with increasing normal load. (author). 13 refs., 5 figs., 2 tabs

  10. A glass of red wine to keep vascular disease at bay, but what about pemphigus vulgaris?

    Science.gov (United States)

    Caldarola, Giacomo; Feliciani, Claudio

    2011-03-01

    Pemphigus vulgaris is a rare autoimmune blistering disease, involving the skin and mucous epithelia, which is characterized by flaccid blisters and erosions. It is caused by the presence of autoantibodies directed against desmoglein, a glycoprotein that plays a critical role in cell-cell attachment. Upon a predisposing genetic background, different agents have been shown to act as triggers for the pathogenesis of pemphigus. The most evident association is with drug intake, while the role of diet is often underestimated. The aim of this article is to review the possible role of tannins, a group of phenolic metabolites that are widely distributed in almost all plant foods and beverages, particularly red wine, as a trigger for pemphigus vulgaris.

  11. Linear IgA bullous dermatosis in a neonate.

    Science.gov (United States)

    Hruza, L L; Mallory, S B; Fitzgibbons, J; Mallory, G B

    1993-06-01

    A newborn black boy had two facial blisters at birth that progressed to bullous lesions over the trunk, genitals, extremities, and oral and tracheal mucosa. A biopsy specimen demonstrated a subepidermal bulla with mixed eosinophilic and neutrophilic, inflammatory infiltrate. Direct immunofluorescence showed linear IgA, IgG, and C3 depositions along the basement membrane zone, consistent with a diagnosis of childhood linear IgA bullous dermatosis (chronic bullous dermatosis of childhood). The skin disease was controlled with combined prednisone and dapsone. This is the youngest reported patient with the disease. Linear IgA bullous dermatosis should be considered in the differential diagnosis of blistering diseases of the newborn, and immunofluorescence should be performed on a skin biopsy specimen.

  12. In vivo UVB irradiation induces clustering of Fas (CD95) on human epidermal cells

    DEFF Research Database (Denmark)

    Bang, Bo; Gniadecki, Robert; Larsen, Jørgen K

    2003-01-01

    In vitro studies with human cell lines have demonstrated that the death receptor Fas plays a role in ultraviolet (UV)-induced apoptosis. The purpose of the present study was to investigate the relation between Fas expression and apoptosis as well as clustering of Fas in human epidermis after...... a single dose of UVB irradiation. Normal healthy individuals were irradiated with three minimal erythema doses (MED) of UVB on forearm or buttock skin. Suction blisters from unirradiated and irradiated skin were raised, and Fas, FasL, and apoptosis of epidermal cells quantified by flow cytometry....... Clustering of Fas was from skin biopsied. Soluble FasL in suction blister fluid was quantified by ELISA. Flow cytometric analysis demonstrated increased expression intensity of Fas after irradiation, with 1.6-,2.2- and 2.7-fold increased median expression at 24, 48 and 72 h after irradiation, respectively (n...

  13. Radioimmunoassay of total IgE and allergen-specific IgE antibodies with a uniform indicator system in allergies of childhood

    International Nuclear Information System (INIS)

    Struy, H.; Schuster, R.; Sollich, V.; Thal, W.; Morenz, J.

    1984-01-01

    Solid-phase radioimmunoassays for the determination of allergen-specific and total IgE have been developed. In an indirect solid-phase radioimmunoassay for the measurement of allergen-specific antibodies PVC blisters coated with allergens and in a sandwich solid-phase radioimmunoassay blisters coated with antihuman IgE antibodies are incubated sequentially with patient serum, unlabelled antihuman IgE from rabbits purified by affinity chromatography, and finally with antirabbitglobulin from sheep. Antirabbitglobuline was purified by immunoadsorption. The 125 I-labelled antibody with a specific activity of 30 kBq/μg antibody protein could be used universally for the determination of antibodies of each immunoglobulin class. In 160 patients mostly with seasonal asthma these assays supported RAST and PRIST kits and were helpful in the diagnosis of atopic diseases. (author)

  14. Development of beryllium-based neutron target system with three-layer structure for accelerator-based neutron source for boron neutron capture therapy.

    Science.gov (United States)

    Kumada, Hiroaki; Kurihara, Toshikazu; Yoshioka, Masakazu; Kobayashi, Hitoshi; Matsumoto, Hiroshi; Sugano, Tomei; Sakurai, Hideyuki; Sakae, Takeji; Matsumura, Akira

    2015-12-01

    The iBNCT project team with University of Tsukuba is developing an accelerator-based neutron source. Regarding neutron target material, our project has applied beryllium. To deal with large heat load and blistering of the target system, we developed a three-layer structure for the target system that includes a blistering mitigation material between the beryllium used as the neutron generator and the copper heat sink. The three materials were bonded through diffusion bonding using a hot isostatic pressing method. Based on several verifications, our project chose palladium as the intermediate layer. A prototype of the neutron target system was produced. We will verify that sufficient neutrons for BNCT treatment are generated by the device in the near future. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Low level light therapy and tattoos: A case report.

    Science.gov (United States)

    Ingenito, Teresa

    2016-10-01

    Physical therapists (PTs) frequently provide neuromusculoskeletal treatment for patients who incidentally may have one or more tattoos. Low level light therapy (LLLT) is one of the modalities commonly used by physical therapists to decrease pain and facilitate healing. This case report describes a 22 year old man who was given LLLT to address his complaints of musculoskeletal pain. Blistering of the skin was documented over the LLLT application site, a black tattoo. The blisters, which formed after the LLLT treatment were most likely caused by the inadvertent and unexpected heating of the iron oxides and/or the metal salts in the tattoo's black pigment. PTs should exercise caution when applying LLLT in the presence of dark tattoos. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Meshed split skin graft for extensive vitiligo

    Directory of Open Access Journals (Sweden)

    Srinivas C

    2004-05-01

    Full Text Available A 30 year old female presented with generalized stable vitiligo involving large areas of the body. Since large areas were to be treated it was decided to do meshed split skin graft. A phototoxic blister over recipient site was induced by applying 8 MOP solution followed by exposure to UVA. The split skin graft was harvested from donor area by Padgett dermatome which was meshed by an ampligreffe to increase the size of the graft by 4 times. Significant pigmentation of the depigmented skin was seen after 5 months. This procedure helps to cover large recipient areas, when pigmented donor skin is limited with minimal risk of scarring. Phototoxic blister enables easy separation of epidermis thus saving time required for dermabrasion from recipient site.

  17. Behaviour of plasma-sprayed TiC coatings under H and He irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Fournier, D; Saint-Jacques, R G; Ross, G G; Terreault, B

    1987-02-01

    The effects of H and He irradiation on plasma-sprayed TiC coatings have been studied. The effects were studied by SEM and TEM microscopy, and by H depth-profiling with the ERD technique. Samples prepared by CVD were also implanted for comparison. In the case of H, bubbles have been observed during an in-situ implantation inside the TEM. In order to understand the absence of hydride, H depth-profiling was performed. The H saturation concentration is about 20 at.% or slightly more (the uncertainty is due to the effect of the porosity of the coatings on the ERD technique). Helium bubbles are observed above 10/sup 15/Hecm/sup 2/. Blisters are formed on polished samples above 10/sup 17/Hecm/sup 2/. In contrast, the high roughness of non-polished samples prevents blister formation. CVD samples behave essentially like the polished samples.

  18. Feasibility of mHealth and Near Field Communication technology based medication adherence monitoring.

    Science.gov (United States)

    Morak, Juergen; Schwarz, Mark; Hayn, Dieter; Schreier, Guenter

    2012-01-01

    Poor patients' adherence to intake of prescribed medication has been identified as a serious problem in the treatment of chronically ill patients. Technical solutions are needed to measure and - if necessary - to increase the patients' adherence. A telemonitoring solution was developed to record a patient's medication intake based on smart blisters and mobile phones with NFC functionality. The components allowed recording of drug type, timestamp, and dosage of pills taken. The system's usability and technical feasibility was evaluated in the course of an application study. Over a period of 13 months 59 patients suffering from diabetes were monitored. 1,760 blisters were handed out to these patients and 14,843 takeout events were recorded and transmitted via mobile phone. Results indicate the feasibility of this concept to monitor adherence. Although the system still needs to be optimized for routine use it shows the potential for targeting the problem of poor patient adherence by NFC enabled devices.

  19. Components made of corrosion-resistent zirconium alloy and method for its production

    International Nuclear Information System (INIS)

    Hanneman, R.E.; Urquhart, A.W.; Vermilyea, D.A.

    1977-01-01

    The invention deals with a method to increase the resistance of zirconium alloys to blister corrosion which mainly occurs in boiling-water nuclear reactors. According to the method described, the surface of the alloy body is coated with a thin film of a suitable electronically conducting material. Gold, silver, platinum, nickel, chromium, iron and niobium are suitable as coating materials. The invention is more closely explained by means of examples. (GSC) [de

  20. Limited infection upon human exposure to a recombinant raccoon pox vaccine vector

    Science.gov (United States)

    Rocke, T.E.; Dein, F.J.; Fuchsberger, M.; Fox, B.C.; Stinchcomb, D.T.; Osorio, J.G.

    2004-01-01

    A laboratory accident resulted in human exposure to a recombinant raccoon poxvirus (RCN) developed as a vaccine vector for antigens of Yersinia pestis for protection of wild rodents (and other animals) against plague. Within 9 days, the patient developed a small blister that healed within 4 weeks. Raccoon poxvirus was cultured from the lesion, and the patient developed antibody to plague antigen (F1) and RCN. This is the first documented case of human exposure to RCN.

  1. Department of Defense Dictionary of Military and Associated Terms

    Science.gov (United States)

    2016-02-15

    via an aeromedical evacuation system or system echelon. (JP 4-02) aeronautical chart — A specialized representation of mapped features of the Earth...blisters the skin. Also called vesicant agent. (JP 3-11) blood agent — A chemical compound, including the cyanide group, that affects bodily functions...combat and operational stress — The expected and predictable emotional , intellectual, physical, and/or behavioral reactions of an individual who has

  2. Needle reactions in resistance to Cronartium ribicola: Hypersensitivity response or not?

    Science.gov (United States)

    Katarina Sweeney; Jeffrey Stone; Kathy Cook; Richard A. Sniezko; Angelia Kegley; Anna W. Schoettle

    2012-01-01

    White pine blister rust (WPBR) is caused by the fungal pathogen Cronartium ribicola. The pathogen is native to Eurasia and was introduced to North America early in the 20th century and is still spreading destructively throughout the range of native western white pines (Douglas ex D. Don) (McDonald and Hoff 2001). All of the North American five-needle (white) pines are...

  3. Traditional Herbal Remedies for Burn Wound Healing in Canon of Avicenna

    OpenAIRE

    Aliasl, Jale; Khoshzaban, Fariba

    2013-01-01

    Burns are a worldwide problem. The incidence of severe burns has been higher than the combined incidence of tuberculosis and HIV infections. Throughout history there have been many different treatments prescribed for burns. The Canon is the masterpiece of Avicenna’s medical books. The Canon includes a description of 785 simple drugs. Avicenna believed in burn treatment, which follows two goals. The first goal is prevention of blistering and the second goal is treatment of the burn wound after...

  4. Use of etanercept to treat toxic epidermal necrolysis in a human immunodeficiency virus-positive patient

    OpenAIRE

    Yung-Yi Lee; Jui-Hung Ko; Chia-Hung Wei; Wen-Hung Chung

    2013-01-01

    Toxic epidermal necrolysis (TEN) is an uncommon and severe cutaneous adverse drug reaction that causes disseminated necrosis of epidermal cells and mucocutaneous detachment. Here, we report the case of a 32-year-old man with human immunodeficiency virus infection who presented with generalized violaceous macules and blister formation 4 days after the administration of mefenamic acid and amoxicillin for a dental procedure. Additional symptoms included oral ulcers and conjunctivitis. Results of...

  5. Peeling skin in newborn with abdominal distension

    OpenAIRE

    Sujay Kumar Maitra; Nilay Kanti Das; Niharika Ranjan Lal

    2016-01-01

    Epidermolysis bullosa (EB) is a rare hereditary disorder characterized by the formation of blisters following minor trauma. It has been traditionally categorized by the level of basement membrane zone separation into EB simplex, junctional EB, and dystrophic EB. Recently, hemidesmosomal EB has been proposed as a fourth category, which includes EB with muscular dystrophy and EB with pyloric atresia (PA). Among the subtypes, EB with PA is a rare form of EB. We report here a neonate with EB-PA, ...

  6. Evaluation of diminished microbial contamination in handling of a novel daily disposable flat pack contact lens.

    Science.gov (United States)

    Nomachi, Miya; Sakanishi, Kotaro; Ichijima, Hideji; Cavanagh, H Dwight

    2013-05-01

    To evaluate the efficacy of a novel daily disposable (DD) flat package in regard to microbial contamination on the anterior and posterior surfaces of a contact lens (CL) during handling of the lens for insertion. Four kinds of commercially available general blister-packed daily disposable contact lenses (DD CLs) as controls and a novel Magic 1-day Menicon Flat Pack as a test lens were used for this in vitro study. Lenses were removed from their packages using fingers coated with fluorescein 3 to 5 μm beads or an approximately 7×10(2) to 2×10(3) colony-forming unit (CFU)/mL Staphylococcus aureus suspension. The transfer of fluorescein beads to the surface of the lenses was then observed by fluorescence microscopy. Microbial contamination on the lenses was observed by light microscopy after a 2-day incubation period; and, the number of colonies isolated from the contaminated lenses was determined after 4 days of incubation. The number of fluorescein beads on the Magic lens was significantly less (p<0.05) than that of the general blister-packed control lenses. Adherence of microbial colonies was observed on both inner and outer surfaces of general blister-packed lenses, whereas no colony formation was found on the inner surface of the Magic lens, and the lowest bacterial adherence was observed for the Magic lens. The data demonstrated that placement of the Magic DD lens onto the eye is accompanied by diminished microbial contamination compared with general blister-packed DD CLs. Eye care professionals; however, should instruct patients to comply with intended use of DD CLs to prevent CL-associated microbial keratitis. In all cases, hand washing is mandated prelens insertion.

  7. Metallograph for the examination of low-level radioactive samples

    International Nuclear Information System (INIS)

    Cook, J.H.; Shaffer, D.S.; Petty, W.F.

    1982-01-01

    A new remote-controlled metallograph was built for use in a low-level radiation background. The metallograph is low cost compared to a conventional remote-controlled metallograph. The motors that drive the stage motions and focus are commercially available and attach to the metallograph without modification. The metallograph was installed on a drawer in a blister behind a shielding door. This allows the metallograph to be reached quickly and easily for maintenance and repair

  8. Design of experiments and equipment to test the ballooning characteristics of CANDU pressure tubes

    International Nuclear Information System (INIS)

    Forrest, C.F.; Stern, F.; Hart, R.G.

    1992-01-01

    Experiments have been planned and an apparatus has been designed to enable creep testing of end-of-life pressure tube specimens in a LOCA environment. Effects that could be studied include: annealing of irradiation damage during transient heating; effects of hydride blisters on pressure tube ballooning strains; and, effects of uniformly-distributed hydrogen content on pressure tube ballooning strains. The proposed experimental program will consist of separate effects creep tests on pressure tube sections under transient heating conditions

  9. Reproduction in laboratory of the morphology distribution and orientation of hydrides in different stages fuel cycle; Reproduccion en laboratorio de la morfologia, distribucion y orientacion de hidruros en distintas etapas del ciclo de combustible

    Energy Technology Data Exchange (ETDEWEB)

    Martin-Rengel, M. A.; Gomez, F. J.; Ruiz-Hervias, J.

    2013-07-01

    In this paper, the experimental techniques employed to reproduce in the laboratory the distribution, morphology and orientation of the hydrides during the different steps of the nuclear fuel cycle are reported. A cathodic charging technique was employed to produce ZIRLO cladding samples with an homogeneous distribution of hydrides and concentrations of 150, 250, 500, 1200 and 2000 ppm of hydrogen. The treatments developed to produce radial hydride reorientation, hydride blisters and a peripheral rim of hydrides are described.

  10. Improved dust handling at Inco's Copper Cliff smelter

    International Nuclear Information System (INIS)

    Dutton, A.; Warner, A.E.M.; Humphris, M.J.

    1989-01-01

    The Cooper Cliff Smelter Complex comprises three major production departments - a Nickel Smelter for the processing of nickel concentrated to a low iron, nickel - copper sulphide (Bessemer) matte; a Matte Processing plant for the separation of matte sulphides and the production of market nickel oxides and refinery feeds and a Copper Smelter to process copper concentrates to blister copper. Annual production is currently -114,000 tonnes of copper as blister and -110,000 tonnes of nickel. The nickel concentrate (11-13% Ni, 2-3% Cu) is roasted in multi-hearth roasters, smelted in oxy-fuel fired reverberatory furnaces to a 30-35% CuNiCo matte and converted to Bessemer matte (75% CuNiCo) in Peirce-Smith converters. The Bessemer matte is slow cooled and crushed for subsequent separation by mineral dressing techniques in the Matte Processing plant into nickel (sulphide and metallic) concentrates and a copper (chalcocite) concentrate. Nickel sulphides are further processed in fluid bed reactors to oxide market product or refinery feedstock. The copper concentrate (29-30% Cu, 0.9% No.) is dried in fluid bed driers, smelted to a 40-50% copper matte in an Inco oxygen flash furnace and converted to blister copper in Peirce-Smith converters. The chalcocite concentrate from the matte separation stage is flash converted to a semi-blister (3-4% S, 4-5% Ni) and then finished to lighter conventionally. A schematic process flowsheet of the Smelter Complex is shown in this paper

  11. Bibliography on plasma-wall interactions

    International Nuclear Information System (INIS)

    Okano, J.

    1980-05-01

    Bibliography is compiled for the following subjects: (1) Plasma-wall interactions, general, (2) Sputtering, (3) Chemical sputtering, (4) Blistering, (5) Electron-impact desorption, (6) Thermal desorption and photo-desorption, (7) Emission of secondary electrons and ions, emission of photoelectrons, and material for getters, (8) Gas release and trapping, (9) Approach from surface diagnostics (review). The compilation has not been intended to be complete, but to give a first step toward a further study of the respective subjects. (author)

  12. Military Medicine. Volume 175, August 2010, Supplement. Total Force Fitness for the 21st Century A New Paradigm

    Science.gov (United States)

    2010-08-01

    within 1 hour following high-intensity activity; and (6) wear synthetic blend socks to prevent blisters. The fi rst two interventions speak to the wide...additional risk factors. Service members are given counsel on smoking sensation, custom mouth guards are offered by dental services, and synthetic blend...are equipped to test for marijuana , cocaine, amphetamines, LSD, opiates (including morphine and heroin), barbiturates, and PCP. Every sample is

  13. Methodologies for assessment of the service life of pressure tubes in Indian PHWRs

    International Nuclear Information System (INIS)

    Sinha, R.K.; Sharma, A.; Madhusoodanan, K.; Sinha, S.K.; Malshe, U.D.

    1997-01-01

    For estimating safe service life of pressure tubes in Indian PHWRs, analytical methodologies have been developed to evaluate creep deformation, deuterium pick-up rate, blister growth at cold spot, and operating domain required for achieving leak-before-break. The paper provides an overview of these methodologies, and results of some studies carried out towards evolution of proposed fitness-for-service criteria for a pressure tube in contact with its calandria tube. (author)

  14. A Proposed Formulary Based on the Identification of Medications Determined by Diagnoses/Problems in a Troop Medical Clinic During Calendar Year 1983

    Science.gov (United States)

    1984-08-01

    Fascitis , Leg (1) Tolectin (1) 28. Fascitis , Plantar (1) Motrin (1) 29. Fracture, Stress (Toe) (1) Indocin (1) 30. Ganglion, Wrist (1) ASA (1) 31...AVC Cream Vibramycin G.E. Tylenol Tigan Herpes Genitalis Zovirax 17. WS N.V. 18. GH N.V. 19. AT Ankle Sprain ASA Plantar Fascitis Motrin 20. RT N.V. 1...Loz. 103. JT URI Actifed Blisters, Foot Bacitracin 104. SB Bronchitis E-Mycin Fascitis , Leg Tolectin Sinusitis Ampicillin URI Robitussin Entex Acute

  15. The Navy SEAL Physical Fitness Guide

    Science.gov (United States)

    1997-08-01

    Injuries Reported by a Sample of Male Runners Injury Frequency (%) Knee 23 Achilles Tendon/Calf 16 Metatarsal 11 Hip/Groin/Toenails/Blisters 9 Plantar ... Fascia /Heel 8 Ankle Sprain 7 Shin Splints 6 Nerve/Quadriceps/Hamstring/Back 2 Run Tall Run Relaxed Run Naturally70 Running for Fitness Chapter 5...Name of Injury Description of Injury Plantar Fasciitis Inflammation and tightness of thick fibrous band on sole of foot. Achilles Tendonitis

  16. Limited infection upon human exposure to a recombinant raccoon pox vaccine vector.

    Science.gov (United States)

    Rocke, Tonie E; Dein, F Joshua; Fuchsberger, Martina; Fox, Barry C; Stinchcomb, Dan T; Osorio, Jorge E

    2004-07-29

    A laboratory accident resulted in human exposure to a recombinant raccoon poxvirus (RCN) developed as a vaccine vector for antigens of Yersinia pestis for protection of wild rodents (and other animals) against plague. Within 9 days, the patient developed a small blister that healed within 4 weeks. Raccoon poxvirus was cultured from the lesion, and the patient developed antibody to plague antigen (F1) and RCN. This is the first documented case of human exposure to RCN.

  17. Biochemical and biological characterization of Bothriechis schlegelii snake venoms from Colombia and Costa Rica

    OpenAIRE

    Prezotto-Neto, Jos�� P; Kimura, Louise F; Alves, Andr�� F; Guti��rrez, Jos�� Mar��a; Otero, Rafael; Su��rez, Ana M; Santoro, Marcelo L; Barbaro, Katia C

    2016-01-01

    Snakebites inflicted by the arboreal viperid snake Bothriechis schlegelii in humans are characterized by pain, edema, and ecchymosis at the site of the bite, rarely with blisters, local necrosis, or defibrination. Herein, a comparative study of Bothriechis schlegelii snake venoms from Colombia (BsCo) and Costa Rica (BsCR) was carried out in order to compare their main activities and to verify the efficacy of Bothrops antivenom produced in Brazil to neutralize them. Biochemical (SDS-PAGE and z...

  18. An Investigation on Micro-Raman Spectra and Wavelet Data Analysis for Pemphigus Vulgaris Follow-up Monitoring

    OpenAIRE

    Camerlingo, Carlo; Zenone, Flora; Perna, Giuseppe; Capozzi, Vito; Cirillo, Nicola; Gaeta, Giovanni Maria; Lepore, Maria

    2008-01-01

    A wavelet multi-component decomposition algorithm has been used for data analysis of micro-Raman spectra of blood serum samples from patients affected by pemphigus vulgaris at different stages. Pemphigus is a chronic, autoimmune, blistering disease of the skin and mucous membranes with a potentially fatal outcome. Spectra were measured by means of a Raman confocal microspectrometer apparatus using the 632.8 nm line of a He-Ne laser source. A discrete wavelet transform decomposition method has...

  19. We Were Caught Unprepared: The 2006 Hezbollah-Israeli War

    Science.gov (United States)

    2008-01-01

    and would conduct the majority of its operations using standoff-based fi repower . Available historic evidence appears to indicate this rationale was...south of the Litani. The supplies were secreted in well-fortifi ed bunkers and entrenchments designed to withstand blistering IDF-precision fi repower ...Hezbollah to modify its doctrine. By the early summer of 2006, Hezbollah had transformed its original 13 22 principles of warfare (a doctrine that had

  20. Operating performance of CANDU pressure tubes

    International Nuclear Information System (INIS)

    Cheadle, B.A.; Price, E.G.

    1989-04-01

    The performance of Zircaloy-2 and Zr-2.5 Nb pressure tubes in CANDU reactors is reviewed. The accelerated hydriding of Zircaloy-2 in reducing water chemistries can lower the toughness of this material and it is essential that defect-initiating phenomena, such as hydride blister formation from pressure tube to calandria tube contact, be prevented. Zr-2.5 Nb pressure tubes are performing well with low rates of hydrogen pick-up and good retention of material properties

  1. Fort Bliss Standards for the Treatment of Historic Buildings

    Science.gov (United States)

    2008-05-01

    rust and organic matter such as the tendrils left on the masonry after the removal of ivy. The construction of the building must be considered...flaking paint or moisture blisters on finished surfaces, • dank musty smells in high humid- ity or poorly ventilated areas, • rust and...ture is an integral part of the de NOTE: Remove only as much paint and rus will begin to rust again within a matter of h night. Thorough surface

  2. Three familial cases of Pasini variant of dominant dystrophic epidermolysis

    Directory of Open Access Journals (Sweden)

    Seirafi H

    1999-07-01

    Full Text Available Epidermolysis bullosa (EB is the term applied to a group of disorders whose common primary feature is the formation of blisters following trivial trauma. Hereditary EB comprises 3 major classes: simplex, junctional and dystrophic, and includes more than 23 phenotypes. The albopapuloid pasini variant of dominant dystrophic EB is characterized by a distinctive clinical appearance. In this article, we report this disease in three members of a family (father and two sons.

  3. Quantification of Physical Activity During Basic Combat Training and Associated Injuries

    Science.gov (United States)

    2014-03-31

    sock systems (6) and antiperspirants (7) to reduce foot blisters and the use of mouth guards for the reduction of orofacial injuries (S). These and...simplified list of lying down, sitting, standing, walking or very active. An Israeli Defense Forces study ញ) investigated overuse injuries and PAin ... orofacial injuries during United States Army Basic Military Training. Dent Traumata! 2006, 24:86-90. 9. U.S. Army Public Health Command, Injury

  4. Modes of Action of Intravenous Immunoglobulin in Bullous Pemphigoid.

    Science.gov (United States)

    Li, Ning; Culton, Donna; Diaz, Luis A; Liu, Zhi

    2018-06-01

    Bullous pemphigoid is an autoantibody-mediated skin blistering disease. Previous studies revealed that intravenous Ig is therapeutic in animal models of bullous pemphigoid by saturating the IgG-protective receptor FcRn, thereby accelerating degradation of pathogenic IgG. Sasaoka et al. demonstrate that the inhibitory effects of intravenous Ig on bullous pemphigoid are also associated with negative modulation of cytokine production by keratinocytes. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Developing and managing brand communities through event marketing strategies

    OpenAIRE

    Charitsis, Vasileios

    2009-01-01

    As the market landscape keeps evolving with a blistering pace and traditional marketing approaches are no longer effective in delivering competitive advantage there is a need for new marketing strategies to be implemented. The concept of brand communities has been attracting increasing attention as it provides a platform upon which various kinds of strong relationships centered around a brand can be established, providing a multitude of positive outcomes for brands. The purpose of this study ...

  6. Perspectives on cultural values of California oaks

    Science.gov (United States)

    Paul F. Starrs

    2002-01-01

    The status and prospects of oaks—those native to California and the many elsewhere—are insufficiently known, despite historical volumes of work done in the past and more ongoing today. That globally there is a blistering diversity of oaks in different environments, and put to distinct uses, is beyond dispute. Less agreed upon, though, is their complex history and the...

  7. Demonstration of Smart Fluorescent and Self-Healing Coatings for Severely Corrosive Environments at Vehicle Wash Facilities

    Science.gov (United States)

    2009-08-01

    as well as pipe and tank exteriors providing early detection of coating erosion, cracks , and intercoat blistering. A fluorescing coating used ERDC...poor with widespread areas of peeling and cracking on the exterior siding. Areas of exposed galvanizing were rusting. Structural steel elements...and application of TT-P-86 Type 2 red lead paint and red and white colored alkyd enamel topcoats. The average dry film thickness on the exterior

  8. Stopping Shingles (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2018-01-25

    Shingles, also known as herpes zoster, is a disease characterized by a painful skin rash, with blisters usually occurring on one side of the body. Each year, approximately one million people in the U.S. get the disease. In this podcast, Dr. Mark Pallansch discusses a newly approved vaccine to prevent shingles.  Created: 1/25/2018 by MMWR.   Date Released: 1/25/2018.

  9. Fusion reactor materials

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    The following topics are briefly discussed: (1) surface blistering studies on fusion reactor materials, (2) TFTR design support activities, (3) analysis of samples bombarded in-situ in PLT, (4) chemical sputtering effects, (5) modeling of surface behavior, (6) ion migration in glow discharge tube cathodes, (7) alloy development for irradiation performance, (8) dosimetry and damage analysis, and (9) development of tritium migration in fusion devices and reactors

  10. Emerging non-invasive Raman methods in process control and forensic applications.

    Science.gov (United States)

    Macleod, Neil A; Matousek, Pavel

    2008-10-01

    This article reviews emerging Raman techniques (Spatially Offset and Transmission Raman Spectroscopy) for non-invasive, sub-surface probing in process control and forensic applications. New capabilities offered by these methods are discussed and several application examples are given including the non-invasive detection of counterfeit drugs through blister packs and opaque plastic bottles and the rapid quantitative analysis of the bulk content of pharmaceutical tablets and capsules without sub-sampling.

  11. Contrasting needs of grassland dwellers: habitat preferences of endangered steppe beetles (Coleoptera)

    Czech Academy of Sciences Publication Activity Database

    Čížek, Lukáš; Hauck, David; Pokluda, Pavel

    2012-01-01

    Roč. 16, č. 2 (2012), s. 281-293 ISSN 1366-638X R&D Projects: GA MŠk LC06073 Institutional research plan: CEZ:AV0Z50070508 Keywords : blister beetle * carpathian basin * darkling beetle Subject RIV: EH - Ecology, Behaviour Impact factor: 1.801, year: 2012 http://www.springerlink.com/content/h7523m513164v7l3/

  12. Occurrence of epidermolysis bullosa along with Amelogenesis imperfecta in female patient of India

    Directory of Open Access Journals (Sweden)

    A P Javed

    2013-01-01

    Full Text Available Epidermolysis bullosa (EB is an inherited disorder, which is characteristically presented as skin blisters developing in response to minor injury. Junctional variety of EB is also associated with enamel hypoplasia. Amelogenesis imperfecta presents with abnormal formation of the enamel both in deciduous and permanent dentition. This article describes a previously unreported case of Amelogenesis imperfecta with complete loss of enamel in a young female patient with EB.

  13. Toxic Industrial Chemicals: A Future Weapons of Mass Destruction Threat

    Science.gov (United States)

    2002-05-31

    1937 by Dr. Gerhard Schrader, a chemist conducting insecticide research with organophosphates (Stockholm International Peace Research Institute 1971...International Peace Research Institute 1971 and 1973). Phosgene oxime is known as “ nettle gas,” so named because of its property of intensely irritating...as a WMD. Common TICs Effects of CW Agents Organophosphate Insecticide Nerve Dimethyl Sulfate Blister Methyl Isocyanate Blood Anhydrous Ammonia

  14. Stevens-Johnson syndrome following use of metronidazole in a dental patient.

    Science.gov (United States)

    Mazumdar, Goutameswar; Shome, Koushik

    2014-01-01

    Metronidazole alone rarely causes Stevens-Johnson syndrome (SJS). We present a case of an elderly male patient who, following metronidazole use, developed neurological symptoms followed by pain and blisters on both soles, erythema of face and neck, scrotal itching and erosion, and hemorrhagic encrustation around the lips and oral mucous membrane. Initial neurological symptoms followed by mucocutaneous manifestation of SJS following metronidazole use is probably a new presentation of this case.

  15. A Combination Therapy of JO-1 and Chemotherapy in Ovarian Cancer Models

    Science.gov (United States)

    2014-12-01

    project period, I have presented the project to five undergraduate students that worked in his laboratory to show them an example for how basic...pituitary gland, proximal cervical spinal cord, eye and lacrimal glands (few periductal lymphocytes), spleen (robust follicular activity, moderate...less PLD-associated toxicity, which can be easily evaluated by monitoring the hand-and-food syndrome, in which patients develop painful blistering

  16. Hereditary epidermolysis bullosa. Dental management of three cases.

    Science.gov (United States)

    Serrano Martínez, C; Silvestre Donat, F J; Bagán Sebastián, J V; Peñarrocha Diago, M; Alió Sanz, J J

    2001-01-01

    Hereditary epidermolysis bullosa (EB) is a mucocutaneous disorder characterized by the appearance of blisters and vesicles in response to minimum friction. The digestive mucosa is one of the most frequently affected regions--including the oral mucosa. Three types of EB have been established according to the histological level of the lesion. Thus, simple EB involves intraepidermal bullae that leave no scars, while junctional EB exhibit blisters between the lamina lucida and lamina densa of the basal membrane. These lesions heal leaving atrophy and involve important hypoplastic lesions in the dental enamel. In turn, dystrophic EB presents synechiae-forming subepidermal blisters--the recessive form being the variant involving the greatest oral lesions (microstomia, ankyloglossia, milium cysts and rampant caries). Three cases of EB are presented and their clinical-dental management difficulties are described. The oral manifestations are described, along with the dental treatments provided and the evolution of the periodontal indices over a two-year period following the application of hygiene-preventive and therapeutic measures.

  17. Thermal behaviour of nitrogen implanted into zirconium

    International Nuclear Information System (INIS)

    Miyagawa, S.; Ikeyama, M.; Saitoh, K.; Nakao, S.; Niwa, H.; Tanemura, S.; Miyagawa, Y.

    1994-01-01

    Zirconium films were implanted with 15 N ions of energy 50keV to a total fluence of 1x10 18 ionscm -2 in an attempt to study the formation process and thermal stability of ZrN layers produced by high fluence implantation of nitrogen. Subsequent to the implantation at room temperature, samples were annealed at temperatures of 300 C-900 C. The depth profiles of the implanted nitrogen were measured by nuclear reaction analysis using the 15 N(p,αγ) 12 C at E R =429keV, and the surfaces were examined by thin film X-ray diffraction (XRD) and scanning electron microscopy. There were many blisters 0.2-0.4μm in diameter on the surface of the as-implanted samples and double peaks were observed in the nitrogen depth profiles; they were in both sides of the mean projected range. It was found that most of the blisters became extinct after annealing above 400 C, and the XRD peak (111) intensity was increased with the increase in the annealing temperature. Moreover, 14 N and 15 N implantations were superimposed on Zr samples in order to study the atomic migration of nitrogen at each stage of high fluence implantation. It was found that the decrease in the peak at the deeper layers was related to blister extinction and nitrogen diffusion into underling zirconium which could be correlated with radiation damage induced by post-implanted ions. ((orig.))

  18. Chroococcales em Esteiras Microbianas em Bolha do Brejo do Pau Fincado, Rio de Janeiro, Brasil.

    Directory of Open Access Journals (Sweden)

    Loreine Hermida da Silva e Silva

    2007-07-01

    Full Text Available Chroococcales in blister microbial mats at brejo do Pau Fincado, Rio de Janeiro, Brazil.Brejo do Pau Fincado (220 55’ 56,75” S e 420 16’ 54,7” W is a natural natural coastal aquatical body. It is located at the Lagoa de Araruama complex, formed at least 7000 years ago. The local climate is characterized by low precipitation ratesand high evaporation rates; due to this, the lagoons tend to become ypersalyne. Microbial mats are organic-sedimentary structures composed mainly of cyanobacteria. Whilst the photosynthesis process cyanobacteria induct an environmental change, which leads to calcium carbonate precipitation. The aim of this study was to typify and identify the cyanobacteria at the blister microbial mat. Samples were processed and analyzed using an optical microscope. The blister mat is composed of twelve species of cyanobacteria disposed in a fragile and amorphous mass. In this structure, both quantitative andqualitative domains belong to Chroococcales Westtein 1924. Measurement has shown that the place is very selective, andcyanobacteria presented great resistance and adaptability, because they are forms which had got success surviving to big changes occurred on Earth since the beginning of life and the evolutionary history .

  19. Influence of particle flux density and temperature on surface modifications of tungsten and deuterium retention

    Energy Technology Data Exchange (ETDEWEB)

    Buzi, Luxherta, E-mail: l.buzi@fz-juelich.de [Ghent University, Department of Applied Physics, Sint-Pietersnieuwstraat 41, B-9000 Ghent (Belgium); FOM Institute DIFFER-Dutch Institute for Fundamental Energy Research, Edisonbaan 14, 3439 MN, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Institut für Energie und Klimaforschung – Plasmaphysik, Forschungszentrum Jülich GmbH, Leo-Brandt-Straße, 52425 Jülich (Germany); Université de Lorraine, Institut Jean Lamour, CNRS UMR 7198, Bvd. des Aiguillettes, F-54506 Vandoeuvre (France); Temmerman, Greg De [FOM Institute DIFFER-Dutch Institute for Fundamental Energy Research, Edisonbaan 14, 3439 MN, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Unterberg, Bernhard; Reinhart, Michael; Litnovsky, Andrey; Philipps, Volker [Institut für Energie und Klimaforschung – Plasmaphysik, Forschungszentrum Jülich GmbH, Leo-Brandt-Straße, 52425 Jülich (Germany); Oost, Guido Van [Ghent University, Department of Applied Physics, Sint-Pietersnieuwstraat 41, B-9000 Ghent (Belgium); Möller, Sören [Institut für Energie und Klimaforschung – Plasmaphysik, Forschungszentrum Jülich GmbH, Leo-Brandt-Straße, 52425 Jülich (Germany)

    2014-12-15

    Systematic study of deuterium irradiation effects on tungsten was done under ITER – relevant high particle flux density, scanning a broad surface temperature range. Polycrystalline ITER – like grade tungsten samples were exposed in linear plasma devices to two different ranges of deuterium ion flux densities (high: 3.5–7 · 10{sup 23} D{sup +}/m{sup 2} s and low: 9 · 10{sup 21} D{sup +}/m{sup 2} s). Particle fluence and ion energy, respectively 10{sup 26} D{sup +}/m{sup 2} and ∼38 eV were kept constant in all cases. The experiments were performed at three different surface temperatures 530 K, 630 K and 870 K. Experimental results concerning the deuterium retention and surface modifications of low flux exposure confirmed previous investigations. At temperatures 530 K and 630 K, deuterium retention was higher at lower flux density due to the longer exposure time (steady state plasma operation) and a consequently deeper diffusion range. At 870 K, deuterium retention was found to be higher at high flux density according to the thermal desorption spectroscopy (TDS) measurements. While blisters were completely absent at low flux density, small blisters of about 40–50 nm were formed at high flux density exposure. At the given conditions, a relation between deuterium retention and blister formation has been found which has to be considered in addition to deuterium trapping in defects populated by diffusion.

  20. Influence of particle flux density and temperature on surface modifications of tungsten and deuterium retention

    International Nuclear Information System (INIS)

    Buzi, Luxherta; Temmerman, Greg De; Unterberg, Bernhard; Reinhart, Michael; Litnovsky, Andrey; Philipps, Volker; Oost, Guido Van; Möller, Sören

    2014-01-01

    Systematic study of deuterium irradiation effects on tungsten was done under ITER – relevant high particle flux density, scanning a broad surface temperature range. Polycrystalline ITER – like grade tungsten samples were exposed in linear plasma devices to two different ranges of deuterium ion flux densities (high: 3.5–7 · 10 23 D + /m 2 s and low: 9 · 10 21 D + /m 2 s). Particle fluence and ion energy, respectively 10 26 D + /m 2 and ∼38 eV were kept constant in all cases. The experiments were performed at three different surface temperatures 530 K, 630 K and 870 K. Experimental results concerning the deuterium retention and surface modifications of low flux exposure confirmed previous investigations. At temperatures 530 K and 630 K, deuterium retention was higher at lower flux density due to the longer exposure time (steady state plasma operation) and a consequently deeper diffusion range. At 870 K, deuterium retention was found to be higher at high flux density according to the thermal desorption spectroscopy (TDS) measurements. While blisters were completely absent at low flux density, small blisters of about 40–50 nm were formed at high flux density exposure. At the given conditions, a relation between deuterium retention and blister formation has been found which has to be considered in addition to deuterium trapping in defects populated by diffusion