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Sample records for blebbing walker carcinosarcoma

  1. Lamellipodia and Membrane Blebs Drive Efficient Electrotactic Migration of Rat Walker Carcinosarcoma Cells WC 256.

    Science.gov (United States)

    Sroka, Jolanta; Krecioch, Izabela; Zimolag, Eliza; Lasota, Slawomir; Rak, Monika; Kedracka-Krok, Sylwia; Borowicz, Pawel; Gajek, Marta; Madeja, Zbigniew

    2016-01-01

    The endogenous electric field (EF) may provide an important signal for directional cell migration during wound healing, embryonic development and cancer metastasis but the mechanism of cell electrotaxis is poorly understood. Additionally, there is no research addressing the question on the difference in electrotactic motility of cells representing various strategies of cell movement-specifically blebbing vs. lamellipodial migration. In the current study we constructed a unique experimental model which allowed for the investigation of electrotactic movement of cells of the same origin but representing different modes of cell migration: weakly adherent, spontaneously blebbing (BC) and lamellipodia forming (LC) WC256 cells. We report that both BC and LC sublines show robust cathodal migration in a physiological EF (1-3 V/cm). The directionality of cell movement was completely reversible upon reversing the field polarity. However, the full reversal of cell direction after the change of EF polarity was much faster in the case of BC (10 minutes) than LC cells (30 minutes). We also investigated the distinct requirements for Rac, Cdc42 and Rho pathways and intracellular Ca2+ in electrotaxis of WC256 sublines forming different types of cell protrusions. It was found that Rac1 is required for directional movement of LC to a much greater extent than for BC, but Cdc42 and RhoA are more crucial for BC than for LC cells. The inhibition of ROCK did not affect electrotaxis of LC in contrast to BC cells. The results also showed that intracellular Ca2+ is essential only for the electrotactic reaction of BC cells. Moreover, inhibition of MLCK and myosin II did not affect the electrotaxis of LC in contrast to BC cells. In conclusion, our results revealed that both lamellipodia and membrane blebs can efficiently drive electrotactic migration of WC 256 carcinosarcoma cells, however directional migration is mediated by different signalling pathways.

  2. Lamellipodia and Membrane Blebs Drive Efficient Electrotactic Migration of Rat Walker Carcinosarcoma Cells WC 256

    Science.gov (United States)

    Sroka, Jolanta; Krecioch, Izabela; Zimolag, Eliza; Lasota, Slawomir; Rak, Monika; Kedracka-Krok, Sylwia; Borowicz, Pawel; Gajek, Marta; Madeja, Zbigniew

    2016-01-01

    The endogenous electric field (EF) may provide an important signal for directional cell migration during wound healing, embryonic development and cancer metastasis but the mechanism of cell electrotaxis is poorly understood. Additionally, there is no research addressing the question on the difference in electrotactic motility of cells representing various strategies of cell movement—specifically blebbing vs. lamellipodial migration. In the current study we constructed a unique experimental model which allowed for the investigation of electrotactic movement of cells of the same origin but representing different modes of cell migration: weakly adherent, spontaneously blebbing (BC) and lamellipodia forming (LC) WC256 cells. We report that both BC and LC sublines show robust cathodal migration in a physiological EF (1–3 V/cm). The directionality of cell movement was completely reversible upon reversing the field polarity. However, the full reversal of cell direction after the change of EF polarity was much faster in the case of BC (10 minutes) than LC cells (30 minutes). We also investigated the distinct requirements for Rac, Cdc42 and Rho pathways and intracellular Ca2+ in electrotaxis of WC256 sublines forming different types of cell protrusions. It was found that Rac1 is required for directional movement of LC to a much greater extent than for BC, but Cdc42 and RhoA are more crucial for BC than for LC cells. The inhibition of ROCK did not affect electrotaxis of LC in contrast to BC cells. The results also showed that intracellular Ca2+ is essential only for the electrotactic reaction of BC cells. Moreover, inhibition of MLCK and myosin II did not affect the electrotaxis of LC in contrast to BC cells. In conclusion, our results revealed that both lamellipodia and membrane blebs can efficiently drive electrotactic migration of WC 256 carcinosarcoma cells, however directional migration is mediated by different signalling pathways. PMID:26863616

  3. Lamellipodia and Membrane Blebs Drive Efficient Electrotactic Migration of Rat Walker Carcinosarcoma Cells WC 256.

    Directory of Open Access Journals (Sweden)

    Jolanta Sroka

    Full Text Available The endogenous electric field (EF may provide an important signal for directional cell migration during wound healing, embryonic development and cancer metastasis but the mechanism of cell electrotaxis is poorly understood. Additionally, there is no research addressing the question on the difference in electrotactic motility of cells representing various strategies of cell movement-specifically blebbing vs. lamellipodial migration. In the current study we constructed a unique experimental model which allowed for the investigation of electrotactic movement of cells of the same origin but representing different modes of cell migration: weakly adherent, spontaneously blebbing (BC and lamellipodia forming (LC WC256 cells. We report that both BC and LC sublines show robust cathodal migration in a physiological EF (1-3 V/cm. The directionality of cell movement was completely reversible upon reversing the field polarity. However, the full reversal of cell direction after the change of EF polarity was much faster in the case of BC (10 minutes than LC cells (30 minutes. We also investigated the distinct requirements for Rac, Cdc42 and Rho pathways and intracellular Ca2+ in electrotaxis of WC256 sublines forming different types of cell protrusions. It was found that Rac1 is required for directional movement of LC to a much greater extent than for BC, but Cdc42 and RhoA are more crucial for BC than for LC cells. The inhibition of ROCK did not affect electrotaxis of LC in contrast to BC cells. The results also showed that intracellular Ca2+ is essential only for the electrotactic reaction of BC cells. Moreover, inhibition of MLCK and myosin II did not affect the electrotaxis of LC in contrast to BC cells. In conclusion, our results revealed that both lamellipodia and membrane blebs can efficiently drive electrotactic migration of WC 256 carcinosarcoma cells, however directional migration is mediated by different signalling pathways.

  4. METALLOPROTEINS DURING DEVELOPMENT OF WALKER-256 CARCINOSARCOMA RESISTANT PHENOTYPE.

    Science.gov (United States)

    Chekhun, V F; Lozovska, Yu V; Burlaka, A P; Ganusevich, I I; Shvets, Yu V; Lukianova, N Yu; Todor, I M; Demash, D V; Pavlova, A A; Naleskina, L A

    2015-01-01

    The study was focused on the detection of changes in serum and tumor metal-containing proteins in animals during development ofdoxorubicin-resistant phenotype in malignant cells after 12 courses of chemotherapy. We found that on every stage of resistance development there was a significant increase in content of ferritin and transferrin proteins (which take part in iron traffick and storage) in Walker-256 carc'inosarcoma tissue. We observed decreased serumferritin levels at the beginning stage of the resistance development and significant elevation of this protein levels in the cases withfully developed resistance phenotype. Transferrin content showed changes opposite to that offerritin. During the development of resistance phenotype the tumor tissue also exhibited increased 'free iron' concentration that putatively correlate with elevation of ROS generation and levels of MMP-2 and MMP-9 active forms. The tumor non-protein thiol content increases gradually as well. The serum of animals with early stages of resistance phenotype development showed high ceruloplasmin activity and its significant reduction after loss of tumor sensitivity to doxorubicin. Therefore, the development of resistance phenotype in Walker-256 carcinosarcoma is accompanied by both the deregulation of metal-containing proteins in serum and tumor tissue and by the changes in activity of antioxidant defense system. Thus, the results of this study allow us to determine the spectrum of metal-containing proteins that are involved in the development of resistant tumor phenotype and that may be targeted for methods for doxorubicin sensitivity correction therapy.

  5. Metalloproteins during development of Walker-256 carcinosarcoma resistant phenotype

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    V. F. Chekhun

    2015-04-01

    Full Text Available The study was focused on the detection of changes in serum and tumor metal-containing proteins in animals during development of doxorubicin-resistant phenotype in malignant cells after 12 courses of chemotherapy. We found that on every stage of resistance development there was a significant increase in content of ferritin and transferrin proteins (which take part in iron traffick and storage in Walker-256 carcinosarcoma tissue. We observed decreased serum ferritin levels at the beginning stage of the resistance development and significant elevation of this protein levels in the cases with fully developed resistance phenotype. Transferrin content showed changes opposite to that of ferritin. During the development of resistance phenotype the tumor tissue also exhibited increased ‘free iron’ concentration that putatively correlate with elevation of ROS generation and levels of MMP-2 and MMP-9 active forms. The tumor non-protein thiol content increases gradually as well. The serum of animals with early stages of resistance phenotype development showed high ceruloplasmin activity and its significant reduction after loss of tumor sensitivity to doxorubicin. Therefore, the development of resistance phenotype in Walker-256 carcinosarcoma is accompanied by both the deregulation of metal-containing proteins in serum and tumor tissue and by the changes in activity of antioxidant defense system. Thus, the results of this study allow us to determine the spectrum of metal-containing proteins that are involved in the development of resistant tumor phenotype and that may be targeted for methods for doxorubicin sensitivity correction therapy.

  6. The RBE of Fractionated Fast Neutron on Walker 256 Carcinosarcoma with KCCH-Cyclotron

    International Nuclear Information System (INIS)

    Yoo, Seong Yul; Koh, Kyoung Hwan; Cho, Chul Koo; Park, Charn Il; Kang, Wee Saing

    1987-01-01

    For evaluation of biological effect of p+(50.5 MeV) Be neutron beam produced by Korea Cancer Center Hospital(KCCH) cyclotron the RBE had been measured in experimental tumor Walker 256 carcinosarcoma as well as normal tissue, mouse intestine and bone marrow, in single and fractionated irradiation. As pilot study, the RBE had been measured for the mouse jejunal crypt cells in single whole body irradiation of which the result was 2.8. The obtained RBE values of TCD 50 of Walker 256 tumor, bone marrow and intestine in single irradiation were 1.9, 1.9 and 1.5 respectively. In fractionated irradiation, the RBE value of tumor Walker 256 was decreased as increasing of fraction number and increased as increasing of fraction size

  7. Metabolic changes during development of Walker-256 carcinosarcoma resistance to doxorubicin.

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    Todor, I N; Lukyanova, N Yu; Shvets, Yu V; Lozovska, Yu V; Chekhun, V F

    2015-03-01

    To study indices of energy metabolism, content of K(+) and Mg(++) both in peripheral blood and in Walker-256 carcinosarcoma during development of resistance to doxorubicin. Resistance of Walker-256 carcinosarcoma to doxorubicin has been developed through 12 subsequent transplantations of tumor after the chemotherapy. Parental strain was inhibited by drug by 65%, while transitional resistant substrains - by 30% and 2%, respectively. Determination of biochemical indices in blood serum and homogenates of tumor tissue, level of potassium, magnesium, lactate, glucose, activities of lactate dehydrogenase and glucose-6-phosphate dehydrogenase was performed with the help of biochemical and immune-enzyme analyzer GBG ChemWell 2990 (USA) using standard kits. Polarography was used to determine indices of mitochondrial oxidative phosphorylation. Study of mitochondrial membrane potential was carried out on flow cytometer Beckman Coulter Epics XL using dye JC-1. It has been determined that development of drug resistance causes the decrease of K(+), Mg(++), glucose content in blood serum and increase of these indices in tumor tissue. At the same time, gradual tumor's loss of sensitivity is characterized by decrease of glycolysis activity in it and activation of mitochondrial oxidative phosphorylation and pentose phosphate pathway of glucose degradation, which causes more intensive formation of NADPH. Development of drug resistance of tumor causes certain metabolic changes in organism and tumor. Further study of such changes will make possible to determine tumor and extratumor markers of resistance.

  8. Irradiation of solid Walker carcino-sarcomas after synchronisation with hydroxyurea

    International Nuclear Information System (INIS)

    Wayss, K.; Mattern, J.; Volm, M.

    1980-01-01

    Sprague-Dawley rats with solid Walker carcino-sarcomas were synchronized with hydroxyurea (HU; 6 x 50 mg and 1 x 300 mg HU/kg body weight) and then irradiated at different time points ( 60 Co). The synchronized tumors showed a significant delay of growth when irradiation was applied in the late G1 phase, at the transition G1/S and in the early S phase. The remaining phases of the cell cycle, especially the S phase showed the same sensitivity as the non-synchronized controls. Improvement of therapy by irradiation after HU application was largely due to the synchronization of tumor cells. Only the increased therapeutic effect of irradiation shortly after application of HU can be explained also by combination of both HU and irradiation. (orig.) 891 MG/orig. 892 MKO [de

  9. Combined therapy of the Walker-256 carcinosarcoma with X-rays and ICRF-159

    International Nuclear Information System (INIS)

    Schaphaus, A.

    1974-01-01

    The radiosensitivity of the Walker-256 carcinosarcoma of the rat under the influence of the tumour-inhibiting bisdioxopiperazine ICRF-159 was studied in collectives of 11-16 animals with tumours. In the combined radio- and chemotherapy, the animals received a daily i.p. injection of 30 mg/kg K.G. of the bisdioxopiperazine ICRF-159 in 1.0 ml NaCl solution containing carboxyl methyl cellulose. The tumour inhibition was determined by multidimensional measurements of the increase in tumour size with the aid of a slide gange. The combined therapy had a better inhibiting effect on tumour growth than radiotherapy alone. (orig./AK) [de

  10. The influence of whole-body and local irradiation modified by hyperglycemia on metastatic Walker carcinosarcoma 256 in rats

    International Nuclear Information System (INIS)

    Kutlimuratov, A.B.; Ivashkin, A.V.; Zakirkhodzhaev, U.D.

    1990-01-01

    It has been shown that the local radiation therapy, and also radiation therapy modified by the short-term hyperglycemia really increase the life-span of rats with Walker 256 carcinosarcoma. At the same time the metastatic process also increases, especially after the modified radiation therapy. The total irradiation of experimental animals in a dose of 50 sGy before the modified radiation therapy considerably decreases the frequency of metastatic process. A conclusion is drawn that the total irradiation has a prophylactic influence on metastases under conditions of modified radiation therapy

  11. Effect of x-irradiation in rats bearing walker-256-carcinosarcoma and normal rats

    International Nuclear Information System (INIS)

    Ehara, Kazuhiko

    1978-01-01

    Serum protein fractions and total proteins were studied with bloods obtained from the rats exposed each to the partial-, whole-bodies and the transplanted tumors (Walker-256-carcinosarcoma transplanted in the right hind leg). The electrophoretic variation induced in the sera of tumor-bearing rats (Group II), and the content of total proteins decreased. Early irradiation to the tumor part of rats less induced the variations of the electrophoretic pattern and the decrease of the amount of serum total proteins. When the distant metastasis appeared during irradiation treatment, the electrophoretic patterns and content of total proteins changed proportionally to the variation in sera of Group II. On the other hand, the γ-globulin (G) fraction increased in the long-term survival rat. The separation of the rat serum β-G into two peaks of β 1 - and β 2 -G was shown only in Group IV (late irradiation to the right hind leg). This finding supposed that some factors involve in the sera of rats with transplanted primary tumor grown up to a fixed size and guessed the appearance of the distant metastasis during x-irradiation. The percentages of the albumin and γ-G decreased slightly and those of the α 1 -, α 2 - and β-G increased slightly in the rats with 300 rad partial-body (the right hind leg) x-irradiation daily for 20 days. The remarkable decrease of the albumin and γ-G, the increase of the α 1 - and β-G, the marked increase of the α 2 -G and the decrease of serum total proteins were demonstrated for the sera of rats with 1,000 rad whole-body x-irradiation at a time. These phenomena seem to be related to the destructive and reticuloendothelial injury by the exposure. (auth.)

  12. Action of tacrolimus on Wistar rat kidneys implanted with Walker 256 carcinosarcoma Estudo da ação do tacrolimus em rins de ratos Wistar implantados com carcinossarcoma de Walker

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    Cristiano Machado Inácio

    2010-02-01

    Full Text Available PURPOSE: To evaluate the development of Walker 256 tumor in male Wistar rats treated with tacrolimus using an experimental kidney tumor model. METHODS: 40 male Wistar rats were divided into four groups: Tumor group (TU (n=10, Tacrolimus-Tumor group (TT (n=10, Tacrolimus group (TC (n=10 and Control group (C (n=10. Treatment with tacrolimus was performed in groups TT and TC. Under anesthesia, the right kidney of each animal of TU and TT was accessed through a supraumbilical incision and inoculated with a 0.1mL solution containing 2x10(6 tumor cells (Walker 256 carcinosarcoma tumor cells. Group TC was treated with a saline solution. All the animals of groups TC and TT were treated with tacrolimus (5mg/kg/day by gavage for 15 days. TU group animals received saline by gavage for 15 days. On the 15th postoperative day, all animals were submitted to euthanasia and blood sampling for analysis of serum creatinine (Cr and blood urea nitrogen (BUN. Abdominal gross examination was performed, the right kidney removed and prepared for histological analysis by hematoxylin-eosin staining. The resulting data were submitted to statistical analysis by ANOVA. RESULTS: Statistical significance was found when comparing creatinine level between groups TU, TT and TC -TT group culminated with a marked increased in creatinine levels (Cr=1.013 ± 0.3028 mg/mL, TU group (Cr=0.5670 ± 0.03536 mg/dL P=0.00256, TC group (Cr =0.711 ± 0.1653 mg/mL P= 0.02832. Statistical significance was found when comparing BUN levels in TT group (71.32 ± 17.14 mg/mL, compared with TU group (45.83 ± 5.046 mg/dL, P=0.000318. There were no statistically significant differences between groups TT and TC (61.23 ± 9.503 mg/mL P=0.7242. Histological analysis showed a poor evolution in TT group with multiple foci of hemorrhage and cortical invasion by the Walker tumor. CONCLUSION: The Tacrolimus-treated group developed a more aggressive tumor and a drug-related nephrotoxic effect.OBJETIVO: Avaliar

  13. Three mechanical models for blebbing and multi-blebbing

    KAUST Repository

    Woolley, T. E.

    2014-06-17

    Membrane protrusions known as blebs play important roles in many cellular phenomena. Here we present three mathematical models of the bleb formation, which use biological insights to produce phenotypically accurate pressure-driven expansions. First, we introduce a recently suggested solid mechanics framework that is able to create blebs through stretching the membrane. This framework is then extended to include reference state reconfigurations, which models membrane growth. Finally, the stretching and reconfiguring mechanical models are compared with a much simpler geometrically constrained solution. This allows us to demonstrate that simpler systems are able to capture much of the biological complexity despite more restrictive assumptions. Moreover, the simplicity of the spherical model allows us to consider multiple blebs in a tractable framework. © 2014 The authors 2014. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

  14. Prostatic carcinosarcoma with lung metastases.

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    Furlan, Stefanie R; Kang, David J; Armas, Armando

    2013-01-01

    Carcinosarcoma of the prostate is an uncommon malignancy with poor long-term prognosis. The cancer is typically discovered at an advanced stage, and with less than 100 reported cases, there is limited literature concerning treatment options. Our patient presented with a history of benign prostatic hypertrophy, erectile dysfunction, and nocturia. Biopsy of his prostate indicated that the patient had prostatic adenocarcinoma, but histopathology after prostatectomy revealed carcinosarcoma. It has been over six years since this patient's diagnosis of carcinosarcoma. Over this span of time, he has received a radical prostatectomy, radiotherapy, and androgen ablative therapy. The patient also developed multiple lung metastases that have been treated with video-assisted thoracic surgery and stereotactic body radiosurgery. Overall, he has remained unimpaired and in good condition despite his aggressive form of cancer.

  15. Review literature on uterine carcinosarcoma

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    Rajendra Singh

    2014-01-01

    Full Text Available Carcinosarcoma of the uterus is a rare gynaecological neoplasm, which is also known as malignant mixed mesodermal tumor. Traditionally this tumour has been regarded as a subtype of uterine sarcoma, and its origin remains controversial. The exact nature and prognosis was not clear in the past. It is believed that uterine carcinosarcoma have a Mullerian duct origin and have a capacity to differentiate into various mesenchymal and epithelial components. Regarding the histogensis, various theories have been given; of which ′conversion theory′ was broadly accepted. Carcinosarcoma are mostly of monoclonal origin with the carcinomatous component being the driving force. This type of tumor is broadly divided into two groups, homologous and heterologous, depending on the characteristics of the stroma or mesenchymal components of endometrial tissue. It is more frequent in black women and postmenopausal women. Radiation is a possible etiological factor but the exact etiology is not known yet. However, tamoxifen may induce carcinogenesis in some patients. Its clinical feature is very similar to endometrial carcinoma i.e. postmenopausal vaginal bleeding, have a very aggressive behavior and a poor prognosis. This pelvic malignancy is treated by multimodality therapy including surgery, chemotherapy and radiotherapy. Here we are reviewing old concepts about the disease and modern understandings of the origin, classification, pathogenesis and recent advances in the treatment of the uterine carcinosarcoma.

  16. Rapidly Growing Esophageal Carcinosarcoma Reduced by Neoadjuvant Radiotherapy Alone

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    Naotaka Ogasawara

    2014-06-01

    Full Text Available Esophageal carcinosarcoma is a rare malignant neoplasm consisting of both carcinomatous and sarcomatous components. It is generally treated by surgery, radiotherapy and chemotherapy according to the protocols used for other esophageal cancers. However, the treatment of esophageal carcinosarcoma by radiotherapy alone before surgery has not been previously described. We report a patient with a rapidly growing esophageal carcinosarcoma that was efficiently reduced by neoadjuvant radiotherapy alone. A previously healthy 69-year-old man was admitted with dysphagia. Initial esophagogastroduodenoscopy (EGD revealed a small nodular polypoid lesion of about 10 mm in the middle esophagus. A second EGD 1 month later showed that the tumor had expanded into a huge mass. A biopsy specimen revealed that the tumor comprised squamous cell carcinoma with spindle cell components, and the tumor was diagnosed as carcinosarcoma which was diagnosed as stage I (T1bN0M0. Due to renal dysfunction, the patient was treated with neoadjuvant radiotherapy (40 Gy without chemotherapy. A third EGD 1 month later revealed remarkable tumor reduction. He then underwent total esophagectomy with regional lymph node dissection (pStage 0, pT1aN0M0. After surgical operation, the patient was followed up without adjuvant therapy. Whole body computed tomography revealed lung metastasis 14 months after surgery, and the patient died 2 months later. The neoadjuvant radiotherapy for esophageal carcinosarcoma was considered to have contributed to the subsequent surgery and his prolonged survival time. Thus, radiotherapy alone might be a suitable neoadjuvant therapy for esophageal carcinosarcomas.

  17. Carcinosarcoma of the Pancreas: Case Report With Comprehensive Literature Review.

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    Ruess, Dietrich A; Kayser, Claudia; Neubauer, Jakob; Fichtner-Feigl, Stefan; Hopt, Ulrich T; Wittel, Uwe A

    2017-10-01

    Carcinosarcomas are rare biphasic neoplasms with distinct malignant epithelial and mesenchymal components. Most commonly, carcinosarcomas arise in the uterus as malignant mixed müllerian tumors, but also infrequently appear in other organs such as the ovaries and breast, the prostate and urinary tract, the lungs, or in the gastrointestinal system, among others. Pancreatic carcinosarcomas are exceedingly rare; only a few cases are reported in the English literature. Their pathogenesis remains to be fully clarified. We present here the case of a pancreatic carcinosarcoma with evidence for monoclonality via determination of Kras mutational status after microdissection and suggest a common origin of the 2 tumor components. Comprehensive review of the available literature allows the conclusion that most pancreatic carcinosarcomas appear to be of monoclonal origin and seem to have arisen from a carcinoma via metaplastic transformation of 1 part or subclone of the tumor, probably by epithelial-mesenchymal transition. All reported patients were treated with surgery. Adjuvant therapy, if administered, consisted predominantly of gemcitabine. Prognosis for this neoplasm occurs to be similar or even worse compared with classic pancreatic ductal adenocarcinoma. Despite the lack of evidence-based recommendations for its treatment, resection should be performed, if possible.

  18. Cutaneous Carcinosarcoma with Metastasis to the Parotid Gland

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    Tze Ling Loh

    2014-01-01

    Full Text Available Cutaneous carcinosarcoma is a rare malignancy that exhibits both mesenchymal and epithelial components. It is similar to nonmelanoma skin cancers in terms of risk and prognostic factors. However, these malignancies are known to have a propensity for local recurrence and metastasis, even with adequate resection margins. Here we report a case of metastatic cutaneous carcinosarcoma to the parotid gland and review the relevant literature.

  19. Cutaneous Carcinosarcoma with Metastasis to the Parotid Gland

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    Loh, Tze Ling; Tomlinson, Jeanne; Chin, Ronald; Eslick, Guy D.

    2014-01-01

    Cutaneous carcinosarcoma is a rare malignancy that exhibits both mesenchymal and epithelial components. It is similar to nonmelanoma skin cancers in terms of risk and prognostic factors. However, these malignancies are known to have a propensity for local recurrence and metastasis, even with adequate resection margins. Here we report a case of metastatic cutaneous carcinosarcoma to the parotid gland and review the relevant literature.

  20. Primary carcinosarcoma of the fallopian tube: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyeon Wook [Dept. of Radiology, Daegu Fatima Hospital, Daegu (Korea, Republic of); Kim, See Hyung; Kwon, Sun Young [Dept. of Radiology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu (Korea, Republic of)

    2017-08-15

    Carcinosarcomas are biphasic neoplasms composed of epithelial and mesenchymal elements. They are most commonly found in the uterus, with rare involvement of the fallopian tubes. Here, we present a case of primary carcinosarcoma of the fallopian tube. On CT and MRI imaging, it manifested as a tubular heterogeneous enhancing mass, along with necrosis and hemorrhage.

  1. Cellular blebs: pressure-driven, axisymmetric, membrane protrusions

    KAUST Repository

    Woolley, Thomas E.

    2013-07-16

    Blebs are cellular protrusions that are used by cells for multiple purposes including locomotion. A mechanical model for the problem of pressure-driven blebs based on force and moment balances of an axisymmetric shell model is proposed. The formation of a bleb is initiated by weakening the shell over a small region, and the deformation of the cellular membrane from the cortex is obtained during inflation. However, simply weakening the shell leads to an area increase of more than 4 %, which is physically unrealistic. Thus, the model is extended to include a reconfiguration process that allows large blebs to form with small increases in area. It is observed that both geometric and biomechanical constraints are important in this process. In particular, it is shown that although blebs are driven by a pressure difference across the cellular membrane, it is not the limiting factor in determining bleb size. © 2013 Springer-Verlag Berlin Heidelberg.

  2. Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes: a 2-year follow up.

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    Tsai, Andrew S H; Boey, Pui Yi; Htoon, Hla M; Wong, Tina T

    2015-01-01

    To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a 2y period. To compare the success rates between primary angle-closure glaucoma (PACG) and primary open angle glaucoma (POAG). Lastly, to identify factors associated with success of bleb needling. This was a retrospective review of 227 patients who underwent bleb needling between June 2009 and June 2011 in Singapore National Eye Centre. The 5-fluorouracil (5-FU) augmented bleb needling was performed either at the slit lamp or in the operating theatre. Repeat bleb needlings were performed as necessary. Complete success was defined as maintenance of intraocular pressure (IOP) ≥6 mm Hg and ≤21 mm Hg, in the absence of further surgery or use of antiglaucoma medication. Qualified success met the above criteria with or without use of antiglaucoma medications. One hundred and seventy-five eyes completed the two-year follow up. Sixty-nine percent of participants had POAG and 31% had PACG. The mean interval between filtering surgery and bleb needling was 299.9±616.4d for POAG and 167.1±272.2d for PACG. Mean needling attempts were 1.9±1.4 and 2±1.6 for POAG and PACG respectively. In general, there was a statistically significant reduction of IOP ranging from 21.9% to 26.8% from month 1 through to month 24. The complete success rates at month 6 were 70.0% for POAG and 65.7% for PACG. At month 12, this decreased to 62.2% for POAG and PACG and at month 24, 57.9% for POAG and 63.0% for PACG respectively. The qualified success rates at month 6 for POAG and PACG were 23.8% and 29.9% respectively, 32.2% and 29.2% at month 12, and 34.7% and 29.6% at month 24. The success rates between POAG and PACG were not significantly different (P>0.05 for complete and qualified success at months 6, 12 and 24). An increased number of needlings and higher pre-needling IOP were associated with failure. The 5-FU augmented bleb needling within one year of trabeculectomy in Asian eyes can

  3. Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes:a 2-year follow up

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    Andrew S. H. Tsai

    2015-08-01

    Full Text Available AIM:To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a 2y period. To compare the success rates between primary angle-closure glaucoma (PACG and primary open angle glaucoma (POAG. Lastly, to identify factors associated with success of bleb needling.METHODS:This was a retrospective review of 227 patients who underwent bleb needling between June 2009 and June 2011 in Singapore National Eye Centre. The 5-fluorouracil (5-FU augmented bleb needling was performed either at the slit lamp or in the operating theatre. Repeat bleb needlings were performed as necessary. Complete success was defined as maintenance of intraocular pressure (IOP ≥6 mm Hg and ≤21 mm Hg, in the absence of further surgery or use of antiglaucoma medication. Qualified success met the above criteria with or without use of antiglaucoma medications.RESULTS:One hundred and seventy-five eyes completed the two-year follow up. Sixty-nine percent of participants had POAG and 31% had PACG. The mean interval between filtering surgery and bleb needling was 299.9±616.4d for POAG and 167.1±272.2d for PACG. Mean needling attempts were 1.9±1.4 and 2±1.6 for POAG and PACG respectively. In general, there was a statistically significant reduction of IOP ranging from 21.9% to 26.8% from month 1 through to month 24. The complete success rates at month 6 were 70.0% for POAG and 65.7% for PACG. At month 12, this decreased to 62.2% for POAG and PACG and at month 24, 57.9% for POAG and 63.0% for PACG respectively. The qualified success rates at month 6 for POAG and PACG were 23.8% and 29.9% respectively, 32.2% and 29.2% at month 12, and 34.7% and 29.6% at month 24. The success rates between POAG and PACG were not significantly different (P>0.05 for complete and qualified success at months 6, 12 and 24. An increased number of needlings and higher pre-needling IOP were associated with failure.CONCLUSION:The5-FU augmented bleb needling within one year

  4. Neratinib shows efficacy in the treatment of HER2 amplified carcinosarcoma in vitro and in vivo.

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    Schwab, Carlton L; English, Diana P; Black, Jonathan; Bellone, Stefania; Lopez, Salvatore; Cocco, Emiliano; Bonazzoli, Elena; Bussi, Beatrice; Predolini, Federica; Ferrari, Francesca; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Rutherford, Thomas; Schwartz, Peter E; Santin, Alessandro D

    2015-10-01

    Carcinosarcoma is a deadly gynecologic malignancy with few effective treatment options. The study of new therapies is difficult because of its rarity. The objective of this study was to determine the efficacy of neratinib in the treatment of HER2 amplified carcinosarcoma. The efficacy of neratinib in the treatment of HER2 amplified carcinosarcoma was determined in vitro using seven primary carcinosarcoma cell lines with differential expression of HER2/neu. Data regarding IC50, cell cycle distribution, and cell signaling changes were assessed by flow cytometry. The efficacy of neratinib was determined in treating mice harboring HER2 amplified carcinosarcoma xenografts. Two of seven (28.5%) carcinosarcoma cell lines were HER2/neu amplified. HER2/neu amplified cell lines SARARK6 and SARARK9 were significantly more sensitive to neratinib than the five non-HER2/neu amplified carcinosarcoma cell lines (mean±SEM IC50:0.014μM±0.004vs.0.164μM±0.019 p=0.0003). Neratinib treatment caused a significant build up in G0/G1 phase of the cell cycle, arrest auto phosphorylation of HER2/neu and activation of S6. Neratinib inhibited tumor growth (p=0.012) and prolonged survival in mice harboring HER2 amplified carcinosarcoma xenografts (p=0.0039). Neratinib inhibits HER2 amplified carcinosarcoma proliferation, signaling, cell cycle progression and tumor growth in vitro. Neratinib inhibits HER2/neu amplified xenograft growth and improves overall survival. Clinical trials are warranted. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Hemodynamics before and after bleb formation in cerebral aneurysms

    Science.gov (United States)

    Cebral, Juan R.; Radaelli, Alessandro; Frangi, Alejandro; Putman, Christopher M.

    2007-03-01

    We investigate whether blebs in cerebral aneurysms form in regions of low or high wall shear stress (WSS), and how the intraaneurysmal hemodynamic pattern changes after bleb formation. Seven intracranial aneurysms harboring well defined blebs were selected from our database and subject-specific computational models were constructed from 3D rotational angiography. For each patient, a second anatomical model representing the aneurysm before bleb formation was constructed by smoothing out the bleb. Computational fluid dynamics simulations were performed under pulsatile flow conditions for both models of each aneurysm. In six of the seven aneurysms, the blebs formed in a region of elevated WSS associated to the inflow jet impaction zone. In one, the bleb formed in a region of low WSS associated to the outflow zone. In this case, the inflow jet maintained a fairly concentrated structure all the way to the outflow zone, while in the other six aneurysms it dispersed after impacting the aneurysm wall. In all aneurysms, once the blebs formed, new flow recirculation regions were formed inside the blebs and the blebs progressed to a state of low WSS. Assuming that blebs form due to a focally damaged arterial wall, these results seem to indicate that the localized injury of the vessel wall may be caused by elevated WSS associated with the inflow jet. However, the final shape of the aneurysm is probably also influenced by the peri-aneurysmal environment that can provide extra structural support via contact with structures such as bone or dura matter.

  6. Uterine Carcinosarcomas: Clinical, Histopathologic and Immunohistochemical Characteristics.

    Science.gov (United States)

    Chen, Xiaowei; Arend, Rebecca; Hamele-Bena, Diane; Tergas, Ana I; Hawver, Melanie; Tong, Guo-Xia; Wright, Thomas C; Wright, Jason D

    2017-09-01

    Carcinosarcomas (malignant mixed Müllerian tumors or MMMT) are rare malignant tumors in the female genital tract composed of both malignant epithelial and malignant mesenchymal components. They comprise 1995 and 2011 were retrieved from the gynecologic pathology files at Columbia University Medical Center. Representative tissue blocks containing both epithelial and mesenchymal components were selected from each case for histologic and immunohistochemical studies. Clinical data from each case were retrieved. The epithelial component was poorly differentiated adenocarcinoma in the majority (80.7%) of cases; in 17.7%, the carcinoma was moderately differentiated, and in only 1.6% the carcinoma was well differentiated. 53% of the tumors had homologous stromal elements and 47% displayed heterologous stromal elements. Immunohistochemical study revealed almost equal staining in both epithelial and mesenchymal components of carcinosarcomas for p16 and p53. PAX8 positivity was noted in 73% of epithelial components, but only 13% of stromal components, and PAX8 stromal positivity was never seen in the absence of PAX8 epithelial positivity. Expression of p16, p53, and PAX8 in both malignant components lends support to the monoclonal theory of uterine carcinosarcoma tumorigenesis. The roles of these tumor markers in the diagnosis and pathogenesis of this tumor and associations between clinical characteristics, tumor pathologic features, and prognosis are discussed.

  7. Blindness following bleb-related infection in open angle glaucoma.

    Science.gov (United States)

    Yamada, Hiroki; Sawada, Akira; Kuwayama, Yasuaki; Yamamoto, Tetsuya

    2014-11-01

    To estimate the risk of blindness following bleb-related infection after trabeculectomy with mitomycin C in open angle glaucoma, utilizing data obtained from two prospective multicenter studies. The incidence of bleb-related infection in open angle glaucoma after the first or second glaucoma surgery was calculated using a Kaplan-Meier analysis and data from the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS). The rate of blindness following bleb-related infection was calculated using data from the Japan Glaucoma Society Survey of Bleb-related Infection (JGSSBI). Finally, the rate of blindness following bleb-related infection after filtering surgery was estimated based on the above two data sets. Blindness was defined as an eye with a visual acuity of 0.04 or less. The incidences of development of bleb-related infection at 5 years were 2.6 ± 0.7 % (calculated cumulative incidence ± standard error) for all infections and 0.9 ± 0.4 % for endophthalmitis in all cases in the CBIITS data. The rates of blindness in the JGSSBI data were 14 % for the total cases with bleb-related infection and 30 % for the endophthalmitis subgroup. The rate of blindness developing within 5 years following trabeculectomy was estimated to be approximately 0.24-0.36 %. The rate of blindness following bleb-related infection within 5 years after trabeculectomy is considerable and thus careful consideration must be given to the indication for trabeculectomy and the selection of surgical techniques.

  8. Indocyanine green staining facilitates detection of bleb leakage during trabeculectomy.

    Science.gov (United States)

    Okazaki, Teruhiko; Kiuchi, Takahiro; Kawana, Keisuke; Oshika, Tetsuro

    2007-03-01

    To report a new technique to visualize bleb leakage using indocyanine green (ICG) staining during trabeculectomy. The ICG solution was widely applied over the filtering bleb including the conjunctival wound before completion of trabeculectomy. This procedure was performed in 48 eyes of 44 consecutive patients undergoing trabeculectomy between December 2004 and October 2005. Without staining, bleb leakage was not identified by the direct observation under the operating microscope. ICG staining clearly visualized aqueous leakage from the bleb in 5 eyes (10.4%). The bleb leakage in these eyes was easily repaired with 10-0 nylon sutures, and no eyes, including these 5 cases, showed bleb leakage after surgery. There were no intraoperative and postoperative complications related to ICG application. The application of ICG during trabeculectomy is a simple and useful technique to facilitate detection and repair of the bleb leakage.

  9. Microtubule-Mediated Inositol Lipid Signaling Plays Critical Roles in Regulation of Blebbing.

    Directory of Open Access Journals (Sweden)

    Tatsuroh Sugiyama

    Full Text Available Cells migrate by extending pseudopods such as lamellipodia and blebs. Although the signals leading to lamellipodia extension have been extensively investigated, those for bleb extension remain unclear. Here, we investigated signals for blebbing in Dictyostelium cells using a newly developed assay to induce blebbing. When cells were cut into two pieces with a microneedle, the anucleate fragments vigorously extended blebs. This assay enabled us to induce blebbing reproducibly, and analyses of knockout mutants and specific inhibitors identified candidate molecules that regulate blebbing. Blebs were also induced in anucleate fragments of leukocytes, indicating that this assay is generally applicable to animal cells. After cutting, microtubules in the anucleate fragments promptly depolymerized, followed by the extension of blebs. Furthermore, when intact cells were treated with a microtubule inhibitor, they frequently extended blebs. The depolymerization of microtubules induced the delocalization of inositol lipid phosphatidylinositol 3,4,5-trisphosphate from the cell membrane. PI3 kinase-null cells frequently extended blebs, whereas PTEN-null cells extended fewer blebs. From these observations, we propose a model in which microtubules play a critical role in bleb regulation via inositol lipid metabolism.

  10. Extraction and radioimmunological detection of parathormone from the hypercalcaemic Walker carcinosarcoma 256 of the rat

    International Nuclear Information System (INIS)

    Schieber, P.

    1978-01-01

    Out of 1.5 kg solid Walker carcionosarcoma 256, 1682 mg extract were obtained by a specific parathormone extraction technique. This extract was analyzed radioimmunologically with a bovine parathormone standard for comparison. The radioimmunological analysis showed a comparable immunoreactivity in tumour extract and bovine parathormone. This can be seen in the small difference in the rise of regression lines. (orig.) [de

  11. [Bladder carcinosarcoma. A clinical case].

    Science.gov (United States)

    Pena Outeiriño, J M; León Dueñas, E; Romero Gil, J R; Leal López, A

    1995-03-01

    Presentation of a new case of vesical carcinosarcoma in a 49 year-old male patient. The tumour's pathoanatomical study showed an epithelial pattern of transitional and squamous cells and a sarcomatous pattern composed of rabdomiosarcoma, osteochondrosarcoma and pleomorphous indifferentiated sarcoma with giant multinuclear cells. Histogenesis, signs and symptoms, and treatment, as well as the need of performing an immunohistochemical study for its diagnosis are discussed.

  12. Histopathological, immunohistochemical and special stain unraveling the enigmatic carcinosarcoma - A case report

    Directory of Open Access Journals (Sweden)

    Moidin Shakil

    2015-01-01

    Full Text Available Carcinosarcoma is an extremely rare, highly malignant tumor having a characteristic of both epithelial and mesenchymal components; the epithelial component exhibiting focal squamous cell carcinoma and mesenchymal component having sarcomatoid stroma. The occurrence of carcinosarcoma in the oral cavity is very rare and only few cases have been reported in the literature, although its occurrence in other parts of the body has been widely reported.

  13. Salivary gland carcinosarcoma: oligonucleotide array CGH reveals similar genomic profiles in epithelial and mesenchymal components

    NARCIS (Netherlands)

    Vékony, H.; Leemans, C.R.; Ylstra, B.; Meijer, G.A.; van der Waal, I.; Bloemena, E.

    2009-01-01

    In this study, we present a case of parotid gland de novo carcinosarcoma. Salivary gland carcinosarcoma (or true malignant mixed tumor) is a rare biphasic neoplasm, composed of both malignant epithelial and malignant mesenchymal components. It is yet unclear whether these two phenotypes occur by

  14. Primary Cutaneous Carcinosarcoma of the Basal Cell Subtype Should Be Treated as a High-Risk Basal Cell Carcinoma.

    Science.gov (United States)

    Bourgeault, Emilie; Alain, Jimmy; Gagné, Eric

    2015-01-01

    Cutaneous carcinosarcoma is a rare primary tumor of the skin, characterized by biphasic epithelial and mesenchymal differentiation. Due to the limited number of cases reported, there is no consensus regarding treatment and prognosis. Some authors suggest that cutaneous carcinosarcomas should be viewed as aggressive tumors, with ancillary imaging used to evaluate potential metastatic disease. Other reports demonstrate an indolent disease course, especially with epidermal-type cutaneous carcinosarcomas. We report a case of cutaneous carcinosarcoma, which we treated with electrodessication and curettage following a shave biopsy. The tumor had an epithelial component resembling a basal cell carcinoma and a fibrosarcomatous stroma. At 1-year follow-up, our patient did not show evidence of recurrence or metastasis. Our case suggests that a cutaneous carcinosarcoma with an epithelial component composed of basal cell carcinoma can be regarded as a high-risk nonmelanoma skin cancer. © The Author(s) 2015.

  15. Rescue of failed filtering blebs with ab interno trephination.

    Science.gov (United States)

    Shihadeh, Wisam A; Ritch, Robert; Liebmann, Jeffrey M

    2006-06-01

    We evaluated the effectiveness of ab interno automated trephination as a technique for rescuing failed mature filtering blebs. A retrospective chart review of 40 failed blebs of 38 patients who had a posttrephination follow-up period of at least 3 months was done. With success defined as intraocular pressure (IOP) control with other modalities of management. Complications were few. We believe that ab interno trephination is an excellent option for rescuing selected failed filtering blebs.

  16. The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma

    International Nuclear Information System (INIS)

    Clayton Smith, D.; Kenneth Macdonald, O.; Gaffney, David K.

    2008-01-01

    Background and purpose: Uterine carcinosarcoma is an aggressive neoplasm and the benefit of adjuvant radiation therapy (RT) is unclear. This retrospective study analyzes the influence of RT on survival using a large population database. Materials and methods: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) program of the US National Cancer Institute. Women with uterine carcinosarcoma who underwent primary surgery were eligible. Survival rates and multivariate analyses were performed by standard methods. Results: Of the 2461 women in the analysis, 890 received adjuvant RT. Five-year rates of overall survival were 41.5% and 33.2% (P < 0.001) and uterine-specific survival were 56.0% and 50.8% (P = 0.005), for women receiving RT compared to those who did not. Women with stages I-III disease experienced a benefit in overall survival (HR 0.87, P = 0.03) while women with stage IV disease experienced benefits in overall (HR 0.63, P < 0.001) and uterine-specific survival (HR 0.63, P = 0.004) with RT. Conclusions: RT predicted for improved overall and disease specific survival in women with uterine carcinosarcoma within the SEER database. The benefit in disease specific survival was restricted to stage IV disease. These benefits may indicate a role for adjuvant RT in future prospective trials in the treatment of uterine carcinosarcoma

  17. Appraisal of Bleb Using Trio of Intraocular Pressure, Morphology on Slit Lamp, and Gonioscopy

    OpenAIRE

    Thatte, Shreya; Rana, Rimpi; Gaur, Neeraj

    2016-01-01

    Purpose The aim of this study was to assess bleb function using Wuerzburg bleb classification score (WBCS) for bleb morphology on slit lamp, intraocular pressure (IOP), and gonioscopy. Methods A total of randomly selected 30 eyes posttrabeculectomy were assessed for bleb function with the trio of bleb morphology, IOP, and gonioscopy. Bleb was assessed using the WBCS of 0–12 on slit lamp, IOP was assessed using applanation tonometry, and visualization of inner ostium and iridectomy were assess...

  18. The action of fast neutrons on Walker tumor chromatin in rats treated with thiotepa and lomustine cytostatics and with estradiol hormone

    International Nuclear Information System (INIS)

    Radu, L.; Constantinescu, B.; Gostian, O.

    1994-01-01

    Wistar rats bearing Walker carcinosarcoma were treated with thiotepa (1 mg) and lomustine (3 mg) cytostatics and with each of these cytostatics associated with estradiol hormone (0.15 mg). The extracted chromatins were subjected to fast neutrons (d(13 MeV)+Be thick target) at 30-100 Gy doses. The parameters estimated at chromatin samples were: the tyrosine and tryptophan intrinsic fluorescence, the fluorescence of chromatin - ethidium bromide complexes and thermal transition. A different and specific susceptibility to fast neutrons was observed in treated chromatin samples, when compared with controls. The chromatin acidic proteins destruction was greater in the case of estradiol - thiotepa association. (Author)

  19. NEEDLE REVISION WITH MITOMYCIN-C IN ENCAPSULATED BLEBS

    Directory of Open Access Journals (Sweden)

    R Zarei

    2008-08-01

    Full Text Available "nThe most common cause of failure during the first trimester after trabeculectomy is encapsulated bleb and needling bleb revision is a less invasive method in the management of refractory cases. The purpose of this study is to determine the efficacy and safety of mitomycin-C (MMC augmented bleb revision of failed filtration surgery. This study is a before-after (paired observation. 33 patients with failed trabeculectomy because of bleb encapsulation, whose intraocular pressure (IOP was not reduced under 21 mmHg despite of medications and digital massage , underwent needling bleb revision and subconjunctival injection of 0.1 ml MMC (0.4 mg/ml.The mean follow-up time was 9.24 ± 5.27 months (1-20 months. Statistical analysis of the data included the paired two-tailed Student's t test for preoperative and postoperative IOP and number of medications. 36 needling procedures (mean, 1.09 ± 0.21 revisions per eye were performed on 33 eyes. Patients were between 10-80 years old (mean, 45.67 ± 22.41 years and mean follow-up was 9.24 ± 5.27 months. IOP decreased from 29.06 ± 5.03 mmHg to 18.21 ± 6.76 mmHg at last follow-up (P= 0.000. Antiglaucoma medications decreased from 2.18 ± 0.58 to 1.36 ± 0.29 at last follow-up (P= 0.000.Overall, 6 (18.2% of 33 cases achieved a complete success and 20 (60.6% of cases achieved a qualified success. The complications of this procedure were subconjunctival hemorrhage (17 cases, hyphema (5 cases and conjunctival button hole (2 cases. Needling bleb revision with mitomycin-C appears to be an effective and relatively safe way to revive failed filtration surgery.

  20. Early cystic bleb needling revision after glaucoma filtering surgery with toxic keratopathy

    Directory of Open Access Journals (Sweden)

    S. Yu. Petrov

    2015-01-01

    Full Text Available Clinical case of high thin-wall cystic limited filtering bleb needling revision in the early post-op period after trabeculectomy with sinusotomy accompanied by toxic keratopathy is presented. Optical coherence tomography (OCT demonstrated that filtering bleb height was 2700 μm and bleb wall thickness was 70 μm. Bleb needling revision with its lateralwall dissection and subconjunctival injection of dexamethasone, fluorouracil, and ranibizumab near to the bleb site was performed. In 1.5 hours after the procedure, bleb height decreased to 550 μm (by 5 times while bleb wall thickness increased up to 100 μm. Topical antibacterial, steroid, and non-steroid anti-inflammatory therapy was recommended. The next day IOP level reduced from 11 mm Hg to 4.5 mm Hg. It was accompanied by choroidal effusion that was managed conservatively with cycloplegic agents (drops and injections for 3 days. On day 6, central corneal edema affecting all layers, Descemet’s membrane folds, and ocular hypertension were revealed. Metabolic therapy resolved corneal edema within 3 days. Re-needling bleb revision decreased IOP level to 6.2 mm Hg. This resulted in transient Descemet’s membrane folds. This paper describes filtering bleb needling revision with its lateral wall dissection and anti-inflammatory, cytostatic, and anti-VEGF agents use to prolong glaucoma filtering surgery effect in excessive scarring. The procedure was accompanied by toxic corneal endothelium decompensation with corneal edema and Descemet’s membrane folds treated with active metabolic therapy.

  1. Random blebbing motion: A simple model linking cell structural properties to migration characteristics

    Science.gov (United States)

    Woolley, Thomas E.; Gaffney, Eamonn A.; Goriely, Alain

    2017-07-01

    If the plasma membrane of a cell is able to delaminate locally from its actin cortex, a cellular bleb can be produced. Blebs are pressure-driven protrusions, which are noteworthy for their ability to produce cellular motion. Starting from a general continuum mechanics description, we restrict ourselves to considering cell and bleb shapes that maintain approximately spherical forms. From this assumption, we obtain a tractable algebraic system for bleb formation. By including cell-substrate adhesions, we can model blebbing cell motility. Further, by considering mechanically isolated blebbing events, which are randomly distributed over the cell, we can derive equations linking the macroscopic migration characteristics to the microscopic structural parameters of the cell. This multiscale modeling framework is then used to provide parameter estimates, which are in agreement with current experimental data. In summary, the construction of the mathematical model provides testable relationships between the bleb size and cell motility.

  2. Random blebbing motion: A simple model linking cell structural properties to migration characteristics.

    Science.gov (United States)

    Woolley, Thomas E; Gaffney, Eamonn A; Goriely, Alain

    2017-07-01

    If the plasma membrane of a cell is able to delaminate locally from its actin cortex, a cellular bleb can be produced. Blebs are pressure-driven protrusions, which are noteworthy for their ability to produce cellular motion. Starting from a general continuum mechanics description, we restrict ourselves to considering cell and bleb shapes that maintain approximately spherical forms. From this assumption, we obtain a tractable algebraic system for bleb formation. By including cell-substrate adhesions, we can model blebbing cell motility. Further, by considering mechanically isolated blebbing events, which are randomly distributed over the cell, we can derive equations linking the macroscopic migration characteristics to the microscopic structural parameters of the cell. This multiscale modeling framework is then used to provide parameter estimates, which are in agreement with current experimental data. In summary, the construction of the mathematical model provides testable relationships between the bleb size and cell motility.

  3. Carcinosarcoma of the Liver: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jung Hyeok; Kang, Yu Na; Kang, Koo Jeong [Dongsan Medical Center, Keimyung University School of Medicine, Daegu (Korea, Republic of)

    2007-08-15

    A 46-year-old woman was referred after having general weakness for one month. Biochemical indices of liver function were normal. The tumor markers revealed the following: alpha-fetoprotein level, 2.1 ng/mL (< 9.6 ng/mL); carcinoembryonic antigen level, 1.5 ng/mL (< 5.0 ng/mL); serum carbohydrate antigen 19 9 level, 13.2 U/mL (< 39 U/mL). Serum markers for hepatitis B and C were negative. Ultrasonography showed a lobulate heterogeneous echogenic solid mass with a highly echogenic lesion with posterior acoustic shadowing within the mass in the left lobe of the liver. Computed tomographic analysis of the mass revealed peripheral enhancing viable portions, large internal non-enhancing necrotic portions, and a dense radiopaque lesion. In conclusion, the imaging findings of hepatic carcinosarcoma presented in this report showed a large mass with large necrotic portions, small cystic portions, calcifications and bone formations. Although, from a clinical standpoint, establishing an accurate preoperative diagnosis is difficult, carcinosarcoma should be included in the differential diagnosis of a large necrotic hepatic mass, especially if rocky calcifications or bone formations are seen.

  4. A CROSS-SECTIONAL MORPHOLOGICAL AND FUNCTIONAL EVALUATION OF FILTERING BLEBS FIVE YEARS POST TRABECULECTOMY

    Directory of Open Access Journals (Sweden)

    Jyoti Shetty

    2017-06-01

    Full Text Available BACKGROUND After trabeculectomy, wound remodelling and fibrosis continues lifelong and can affect bleb filtration. Ethnicity plays an important role in wound healing. Wound modulation with Mitomycin C affects the morphology as well as long-term functional success of the bleb. The aim of the study is to assess the morphology of blebs 5 years post trabeculectomy using clinical methods (slit lamp biomicroscopy and Moorfields Bleb Grading System MBGS along with Anterior Segment Optical Coherence Tomography (ASOCT and to correlate it with its functional outcome. MATERIALS AND METHODS This prospective cross-sectional study evaluated 40 eyes of 30 patients who had undergone trabeculectomy with adjuvant mitomycin C and had a postoperative duration of 5 years or more. Following a comprehensive ophthalmic examination, grading of filtering bleb was performed using MBGS. Internal bleb morphology was imaged using AS-OCT. RESULTS At the time of surgery, the age of the patients ranged from 33-71 years. The average postoperative duration was 8.6 ± 3.3 years. Based on slit lamp biomicroscopy, we found that 47% of the total blebs were diffuse, 30% were cystic and 23% were flat. MBGS parameters were studied in relation to bleb type on slit lamp. Bleb height (p=0.001 and central bleb vascularity (p=0.010 were found to have statistically significant association. There is a statistically significant agreement between the bleb type on slit lamp examination and morphological classification based on AS-OCT at p<0.05 (p=0.000. We observed complete success in 90% of eyes and qualified success in 100%. IOP at the time of study was found to have negative correlation with total bleb height on AS-OCT (r: -0.3592; p=0.022909. CONCLUSION This case series with a long-term followup period showed that trabeculectomy augmented with Mitomycin C (MMC can achieve good long-term IOP control. The filtering bleb morphology using clinical methods (slit lamp biomicroscopy and MBGS and

  5. The 5-year incidence of bleb-related infection and its risk factors after filtering surgeries with adjunctive mitomycin C: collaborative bleb-related infection incidence and treatment study 2.

    Science.gov (United States)

    Yamamoto, Tetsuya; Sawada, Akira; Mayama, Chihiro; Araie, Makoto; Ohkubo, Shinji; Sugiyama, Kazuhisa; Kuwayama, Yasuaki

    2014-05-01

    To report the 5-year incidence of bleb-related infection after mitomycin C-augmented glaucoma filtering surgery and to investigate the risk factors for infections. Prospective, observational cohort study. A total of 1098 eyes of 1098 glaucoma patients who had undergone mitomycin C-augmented trabeculectomy or trabeculectomy combined with phacoemulsification and intraocular lens implantation performed at 34 clinical centers. Patients were followed up at 6-month intervals for 5 years, with special attention given to bleb-related infections. The follow-up data were analyzed via Kaplan-Meier survival analysis and the Cox proportional hazards model. Incidence of bleb-related infection over 5 years and risk factors for infections. Of the 1098 eyes, a bleb-related infection developed in 21 eyes. Kaplan-Meier survival analysis revealed that the incidence of bleb-related infection was 2.2±0.5% (cumulative incidence ± standard error) at the 5-year follow-up for all cases, whereas it was 7.9±3.1% and 1.7±0.4% for cases with and without a history of bleb leakage, respectively (P = 0.000, log-rank test). When only eyes with a well-functioning bleb were counted, it was 3.9±1.0%. No differences were found between the trabeculectomy cases and the combined surgery cases (P = 0.398, log-rank test) or between cases with a fornix-based flap and those with a limbal-based flap (P = 0.651, log-rank test). The Cox model revealed that a history of bleb leakage and younger age were risk factors for infections. The 5-year cumulative incidence of bleb-related infection was 2.2±0.5% in eyes treated with mitomycin C-augmented trabeculectomy or trabeculectomy combined with phacoemulsification and intraocular lens implantation in our prospective, multicenter study. Bleb leakage and younger age were the main risk factors for infections. Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  6. Carcinosarcoma of the Extrahepatic Bile Duct Presenting with Stone-like Radiological Findings.

    Science.gov (United States)

    Kumei, Shinsuke; Onishi, Yutaka; Ogura, Takeshi; Kusumoto, Chosei; Matsuno, Yasuko; Nishigami, Takashi; Maeda, Mitsuo; Harada, Masaru

    2015-01-01

    A 73-year-old woman was referred to our hospital due to epigastralgia and jaundice. The radiological findings showed a stone-like tumor in the extrahepatic bile duct. The patient was initially thought to have adenocarcinoma of the bile duct based on the findings of a pathological examination of the bile duct biopsy specimen and underwent pancreaticoduodenectomy; the final diagnosis of the lesion was so-called carcinosarcoma of the extrahepatic bile duct. She died of liver metastasis six months after the surgery. This case suggests that surgical resection is not adequate for achieving a radical cure, and the optimal treatment for extrahepatic bile duct carcinosarcoma should be established immediately.

  7. Carcinosarcoma of the uterus-a single institution retrospective analysis of the management and outcome and a brief review of literature.

    Science.gov (United States)

    Anupama, Rajanbabu; Kuriakose, Santhosh; Vijaykumar, D K; Pavithran, K; Jojo, Annie; Indu, R Nair; Sheejamol, V S

    2013-09-01

    Uterine carcinosarcomas are highly aggressive tumors of the uterus associated with a poor prognosis. Though initially classified as sarcomas, now these tumors are classified as carcinomas. The management approach of carcinosarcomas has also changed from those used for high grade sarcomas to that used for managing high grade endometrial carcinomas. The purpose of our study was to analyze the management and outcome of patients with uterine carcinosarcomas treated at our institution and also to attempt a brief review regarding the management of uterine carcinosarcomas. We did a retrospective analysis of all patients with a diagnosis of carcinosarcoma of the uterus treated at our Institution from January 2005 till December 2010. All Patients with a pathological diagnosis of carcinosacrcoma or malignant mixed mullerian tumours of the uterus were included. Data was obtained from the hospital electronic medical records and the hospital cancer registry. Data was analyzed using SPSS v.17. During this 6 year period we had 20 patients with carcinosarcoma of the uterus. 75 % of the patients belonged to Stage I and II. 95 % of the patients underwent Hysterectomy with Bilateral salpingo oophorectomy and 60 % had lymphadenectomy also along with hysterectomy.8 patients had disease recurrence . In patients who had gross extrauterine disease at the time of surgery , the survival was only 9 months whereas in patients who had complete staging with disease confined to the uterus , the survival was 36 months. Carcinosarcomas, accounts for more than 15 % of the uterine cancer associated deaths. Surgery remains the cornerstone of management for these tumors and surgery with pelvic and para aortic lymphadenectomy and peritoneal and omental biopsies is required for the correct staging of the disease and may also provide a survival advantage. Radiation therapy has been shown to provide only better local control without any survival advantage. Further studies are needed to assess

  8. Appraisal of Bleb Using Trio of Intraocular Pressure, Morphology on Slit Lamp, and Gonioscopy.

    Science.gov (United States)

    Thatte, Shreya; Rana, Rimpi; Gaur, Neeraj

    2016-01-01

    The aim of this study was to assess bleb function using Wuerzburg bleb classification score (WBCS) for bleb morphology on slit lamp, intraocular pressure (IOP), and gonioscopy. A total of randomly selected 30 eyes posttrabeculectomy were assessed for bleb function with the trio of bleb morphology, IOP, and gonioscopy. Bleb was assessed using the WBCS of 0-12 on slit lamp, IOP was assessed using applanation tonometry, and visualization of inner ostium and iridectomy were assessed using gonioscopy. Postoperative patients of less than six weeks were excluded from the study. The correlation between WBCS and the duration of trabeculectomy was found to be highly significant ( P value = 0.029). The correlation of IOP with WBCS was also found to be strongly positive ( P = 0.000). IOP was found to be highly associated with peripheral iridectomy ( P = 0.000), internal window ( P = 0.001), and bleb characteristics.

  9. 18F-fluorodeoxyglucose positron emission tomography in uterine carcinosarcoma

    International Nuclear Information System (INIS)

    Ho, Kung-Chu; Yen, Tzu-Chen; Lai, Chyong-Huey; Wu, Tzu-I; Chang, Ting-Chang; Huang, Huei-Jean; Ng, Koon-Kwan; Lin, Gigin; Wang, Chun-Chieh; Hsueh, Swei

    2008-01-01

    Uterine carcinosarcomas clinically confined to the uterus usually harbor occult metastases. We conducted a pilot study to evaluate the value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in uterine carcinosarcoma. Patients with histologically confirmed uterine carcinosarcoma were enrolled. Abdominal and pelvic magnetic resonance imaging (MRI)/whole-body computed tomography (CT) scan, and whole-body 18 F-FDG PET or PET/CT were undertaken for primary staging, evaluating response, and restaging/post-therapy surveillance. The clinical impact of 18 F-FDG PET was determined on a scan basis. A total of 19 patients were recruited and 31 18 F-FDG PET scans (including 8 scans performed on a PET/CT scanner) were performed. Positive impacts of scans were found in 36.8% (7/19) for primary staging, 66.7% (2/3) for monitoring response, and 11.1% (1/9) for restaging/post-therapy surveillance. PET excluded falsely inoperable disease defined by MRI in two patients. Aggressive treatment applying to three patients with PET-defined resectable stage IVB disease seemed futile. Two patients died of disease shortly after salvage therapy restaged by PET. With PET monitoring, one stage IVB patient treated by targeted therapy only was alive with good performance. Using PET did not lead to improvement of overall survival of this series compared with the historical control (n = 35) (P 0.779). The preliminary results suggest that 18 F-FDG PET is beneficial in excluding falsely inoperable disease for curative therapy and in making a decision on palliation for better quality of life instead of aggressive treatment under the guidance of PET. PET seems to have limited value in post-therapy surveillance or restaging after failure. (orig.)

  10. Uterine Carcinosarcoma Confined to the Pelvis: A Retrospective Review and Outcome Analysis

    International Nuclear Information System (INIS)

    Li, H.; TenNapel, M.J.; Bhatia, S.K.; Ahmed, A.; Lin, L.; Jacobson, G.

    2014-01-01

    Objective. We compared the treatments of uterine carcinosarcoma at our institution and evaluated their impact on survival. Methods. A retrospective analysis was performed on 60 eligible patients with carcinosarcoma limited to the pelvis. Subjects were divided into four categories: surgery, surgery plus chemotherapy, surgery plus radiation therapy, and a combination of surgery, chemotherapy, and RT. The most commonly used chemotherapy was cisplatin and/or carboplatin and taxol. Radiotherapy included external beam radiation therapy (EBRT) alone or with high dose rate (HDR) brachytherapy or HDR brachytherapy alone. Survival probability data were computed using the Kaplan-Meier method. The differences between groups were compared using the log-rank test. Results. The combination of surgery and radiation therapy with or without chemotherapy is seen to improve overall survival (OS) compared to surgery alone (Ρ =0.044 and Ρ =0.028 resp.). Brachytherapy involving three HDR vaginal cylinder fractions shows an equally effective reduction in local recurrence compared to EBRT. Conclusion. Our study of a relatively large number of carcinosarcoma patients suggests that adjuvant radiation therapy improves OS compared to surgery alone. Brachytherapy with 3 HDR vaginal cylinder fractions is preferred because of its time-saving, better tolerance, low toxicity and equivalent OS, and local control compared to EBRT.

  11. Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: a case report

    International Nuclear Information System (INIS)

    Cabibi, Daniela; Martorana, Anna; Cappello, Francesco; Barresi, Elisa; Di Gangi, Claudio; Rodolico, Vito

    2006-01-01

    Transformation of a cystic benign teratoma of the ovary into a 'carcinosarcoma' has very rarely been reported and its histogenetic origin is still debated. A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to 'in situ' and infiltrating squamous cell carcinoma (SCC). The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as well as P53 and P63, was found in the sarcomatous component and in some atypical basal cells of the squamous epithelium, which also showed the usual epithelial markers. To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings

  12. Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: a case report

    Directory of Open Access Journals (Sweden)

    Di Gangi Claudio

    2006-03-01

    Full Text Available Abstract Background Transformation of a cystic benign teratoma of the ovary into a "carcinosarcoma" has very rarely been reported and its histogenetic origin is still debated. Case presentation A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to "in situ" and infiltrating squamous cell carcinoma (SCC. The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as well as P53 and P63, was found in the sarcomatous component and in some atypical basal cells of the squamous epithelium, which also showed the usual epithelial markers. Conclusion To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings.

  13. Carcinosarcoma of the Ureter with a Small Cell Component: Report of a Rare Pathologic Entity and Potential for Diagnostic Error on Biopsy

    Directory of Open Access Journals (Sweden)

    Kent Newsom

    2014-01-01

    Full Text Available Carcinosarcomas of the ureter are rare biphasic neoplasms, composed of both malignant epithelial (carcinomatous and malignant mesenchymal (sarcomatous components. Carcinosarcomas of the urinary tract are exceedingly rare. We report a unique case of a carcinosarcoma of the ureter with a chondrosarcoma and small cell tumor component arising in a 68-year-old male who presented with microscopic hematuria. CT intravenous pyelogram revealed right-sided hydroureter and hydronephrosis with thickening and narrowing of the right ureter. The patient underwent robot-assisted ureterectomy with bladder cuff excision and subsequent adjuvant chemotherapy. The patient is disease-free at 32 months after treatment. We provide a brief synoptic review of carcinosarcoma of the ureter and bladder with utilization of immunohistochemical (IHC stains and potential diagnostic pitfalls.

  14. The development of a radioimmunological assay for parathormone formed from the hypercalcemic Walker carcinosarcoma 256

    International Nuclear Information System (INIS)

    Weise, D.

    1981-01-01

    Specific antibodies to Walker Carcinosomal tissue could be produced by immunizing goats with a hypercalcemically active extract of this tumor tissue. These served the stablishment of a radioimmunoassay. The tracer used was 125-iodine labelled borine parathormone. Various parathormone standards were measured in this system. Here it was found that with this new system a specific assay had been developed which measures immunoreactive parathormone. Preliminary serum analyses indicated that endogenous human parathormone is also detected by this new radioimmunoassay. On the basis of comparative measurements with the old antibody directed towards human extractive parathormone and the new antibody for tumor parathormone only limited conclusions are possible. It could, however, be shown that the new antibody is an anti-parathormone-antibody. (orig./MG) [de

  15. Inadvertent filtering bleb following sutureless cataract surgery

    Directory of Open Access Journals (Sweden)

    Jain Sunil

    2005-01-01

    Full Text Available The case history of a sixty-two-year-old lady, who presented with a bleb in the upper part of her left eye following cataract surgery was studied. The patient had no prior history of any glaucoma surgery. Gonioscopy revealed fishmouthing of the internal aspect of the scleral tunnel incision. The diagnosis of post-cataract filtering bleb was made which was managed by resuturing the wound. This case highlights the use of gonioscopy to visualise and evaluate the internal wound and discusses intraoperative recognition of internal leak and its management with horizontal sutures.

  16. Late-Onset Inadvertent Bleb Formation following Pars Plana M3 Molteno Implant Tube Obstruction

    Directory of Open Access Journals (Sweden)

    Anmar M. Abdul-Rahman

    2017-01-01

    Full Text Available Purpose: To report a case of inadvertent bleb formation presenting 18 months after pars plana M3 Molteno implant tube obstruction in a patient with mixed mechanism glaucoma. Materials and Methods: An 84-year-old Caucasian male with mixed mechanism glaucoma underwent slit-lamp examination, gonioscopy, colour anterior segment photography and anterior segment optical coherence tomography (AS-OCT. Results: An inadvertent bleb developed 18 months after pars plana implant tube re-positioning with a 6/0 Vicryl tie ligature. The bleb was located in the area anterior to the implant plate; it was characterised by a thin, transparent, avascular and multi-cystic wall, with a visible stoma at the posterior edge of the bleb. The bleb was functioning as demonstrated by an intraocular pressure of 6 mm Hg at presentation and a punctate fluorescein uptake pattern of the bleb wall. The bleb over the plate of the Molteno implant was non-functioning, likely secondary to tube obstruction by vitreous in the early postoperative period. AS-OCT showed a tract from the anterior chamber commencing at an entry wound through a corneal tunnel to the posterior stoma at the base of the inadvertent bleb. Conclusions: We hypothesise that the pathophysiologic factors resulting in an inadvertent bleb are a result of a combination of apoptosis, late-onset wound dehiscence and internal gaping of a centrally placed corneal wound. In addition, aqueous hydrodynamic factors may play a role.

  17. Utility of histogram analysis of apparent diffusion coefficient maps obtained using 3.0T MRI for distinguishing uterine carcinosarcoma from endometrial carcinoma.

    Science.gov (United States)

    Takahashi, Masahiro; Kozawa, Eito; Tanisaka, Megumi; Hasegawa, Kousei; Yasuda, Masanori; Sakai, Fumikazu

    2016-06-01

    We explored the role of histogram analysis of apparent diffusion coefficient (ADC) maps for discriminating uterine carcinosarcoma and endometrial carcinoma. We retrospectively evaluated findings in 13 patients with uterine carcinosarcoma and 50 patients with endometrial carcinoma who underwent diffusion-weighted imaging (b = 0, 500, 1000 s/mm(2) ) at 3T with acquisition of corresponding ADC maps. We derived histogram data from regions of interest drawn on all slices of the ADC maps in which tumor was visualized, excluding areas of necrosis and hemorrhage in the tumor. We used the Mann-Whitney test to evaluate the capacity of histogram parameters (mean ADC value, 5th to 95th percentiles, skewness, kurtosis) to discriminate uterine carcinosarcoma and endometrial carcinoma and analyzed the receiver operating characteristic (ROC) curve to determine the optimum threshold value for each parameter and its corresponding sensitivity and specificity. Carcinosarcomas demonstrated significantly higher mean vales of ADC, 95th, 90th, 75th, 50th, 25th percentiles and kurtosis than endometrial carcinomas (P Histogram analysis of ADC maps might be helpful for discriminating uterine carcinosarcomas and endometrial carcinomas. J. Magn. Reson. Imaging 2016;43:1301-1307. © 2015 Wiley Periodicals, Inc.

  18. {sup 18}F-fluorodeoxyglucose positron emission tomography in uterine carcinosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Ho, Kung-Chu; Yen, Tzu-Chen [Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Department of Nuclear Medicine and Molecular Imaging Center, Taoyuan (China); Lai, Chyong-Huey; Wu, Tzu-I; Chang, Ting-Chang; Huang, Huei-Jean [Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Kueishan, Taoyuan (China); Ng, Koon-Kwan; Lin, Gigin [Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Department of Medical Imaging and Intervention, Taoyuan (China); Wang, Chun-Chieh [Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Department of Radiation Oncology, Taoyuan (China); Hsueh, Swei [Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Department of Pathology, Taoyuan (China)

    2008-03-15

    Uterine carcinosarcomas clinically confined to the uterus usually harbor occult metastases. We conducted a pilot study to evaluate the value of {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in uterine carcinosarcoma. Patients with histologically confirmed uterine carcinosarcoma were enrolled. Abdominal and pelvic magnetic resonance imaging (MRI)/whole-body computed tomography (CT) scan, and whole-body {sup 18}F-FDG PET or PET/CT were undertaken for primary staging, evaluating response, and restaging/post-therapy surveillance. The clinical impact of {sup 18}F-FDG PET was determined on a scan basis. A total of 19 patients were recruited and 31 {sup 18}F-FDG PET scans (including 8 scans performed on a PET/CT scanner) were performed. Positive impacts of scans were found in 36.8% (7/19) for primary staging, 66.7% (2/3) for monitoring response, and 11.1% (1/9) for restaging/post-therapy surveillance. PET excluded falsely inoperable disease defined by MRI in two patients. Aggressive treatment applying to three patients with PET-defined resectable stage IVB disease seemed futile. Two patients died of disease shortly after salvage therapy restaged by PET. With PET monitoring, one stage IVB patient treated by targeted therapy only was alive with good performance. Using PET did not lead to improvement of overall survival of this series compared with the historical control (n = 35) (P = 0.779). The preliminary results suggest that {sup 18}F-FDG PET is beneficial in excluding falsely inoperable disease for curative therapy and in making a decision on palliation for better quality of life instead of aggressive treatment under the guidance of PET. PET seems to have limited value in post-therapy surveillance or restaging after failure. (orig.)

  19. Enhanced antitumor activity of surface-modified iron oxide nanoparticles and an α-tocopherol derivative in a rat model of mammary gland carcinosarcoma.

    Science.gov (United States)

    Horák, Daniel; Pustovyy, Vitaliy Igorovych; Babinskyi, Andrii Valeriyovich; Palyvoda, Olga Mikhailovna; Chekhun, Vasyl Fedorovich; Todor, Igor Nikolaevich; Kuzmenko, Oleksandr Ivanovich

    2017-01-01

    Maghemite (γ-Fe 2 O 3 ) nanoparticles were obtained by coprecipitation of ferrous and ferric salts in an alkaline medium followed by oxidation; the nanoparticles were coated with poly( N,N -dimethylacrylamide) (PDMA) and characterized by transmission electron microscopy, attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering, thermogravimetric and elemental analyses, and magnetic measurements in terms of particle morphology, size, polydispersity, amount of coating, and magnetization, respectively. The effects of α-tocopherol (Toc) and its phenolic (Toc-6-OH) and acetate (Toc-6-Ac) derivatives on Fe 2+ release from γ-Fe 2 O 3 @PDMA, as well as from γ-Fe 2 O 3 and CuFe 2 O 4 nanoparticles (controls), were examined in vitro using 1,10-phenanthroline. The presence of tocopherols enhanced spontaneous Fe 2+ release from nanoparticles, with Toc-6-OH exhibiting more activity than neat Toc. All of the nanoparticles tested were found to initiate blood lipid oxidation in a concentration-dependent manner, as determined by analysis of 2-thiobarbituric acid reactive species. Wistar rats with Walker-256 carcinosarcoma (a model of mammary gland carcinosarcoma) received Toc-6-Ac, magnetic nanoparticles, or their combination per os, and the antitumor activity of each treatment was determined in vivo. γ-Fe 2 O 3 @PDMA nanoparticles exhibited increased antitumor activity compared to both commercial CuFe 2 O 4 particles and the antitumor drug doxorubicin. Moreover, increased antitumor activity was observed after combined administration of γ-Fe 2 O 3 @PDMA nanoparticles and Toc-6-Ac; however, levels of bilirubin, aspartate aminotransferase, and white bloods normalized and did not differ from those of the intact controls. The antitumor activity of the γ-Fe 2 O 3 nanoparticles strongly correlated with Fe 2+ release from the nanoparticles but not with nanoparticle-initiated lipid peroxidation in vitro.

  20. Treating malfunction filtering bleb with repeated needling combined with adjunctive 5-FU after glaucoma filtration surgery

    Directory of Open Access Journals (Sweden)

    Yi Liu

    2013-07-01

    Full Text Available AIM: To evaluate the therapeutic efficacy of a repeated bleb needling technique combined with subconjunctival injection of 5-FU in eyes with previous glaucoma surgery that had malfunctional filtering blebs. METHODS: A retrospective review of 34 consecutive patients(34 eyesof repeated bleb needling combined with subconjunctival injection of 5-FU in eyes, which had malfunctional filtering blebs after previous glaucoma surgery in our hospital from March 2009 to February 2013 was performed. The intraocular pressures(IOP, shapes of filtering blebs and complications after surgery were analyzed. RESULTS: There was significant reduction of mean IOP from 35.51mmHg to 14.43mmHg(PCONCLUSION: Repeated needling with adjunctive 5-FU proved a highly effective, safe alternative to treat malfunctional filtering blebs after previous glaucoma surgery.

  1. Extragenital malignant mixed Mullerian tumor in the incisional hernia - primary carcinosarcoma in the abdominal wall: Case report

    Directory of Open Access Journals (Sweden)

    Žuvela Marinko

    2015-01-01

    Full Text Available Introduction. This report presents a primary Mullerian carcinosarcoma localized in the incisional hernia i.e. anterior abdominal wall. There is no data in the literature about this localization of extragenital Mullerian carcinosarcoma. Case Outline. The patient had previous medical history of right-sided ovarian cystadenocarcinoma managed by hysterectomy, bilateral ovariectomy and chemotherapy. An incisional hernia occurred 1 year after the operation and Mullerian carcinosarcoma at the right border of the incisional hernia 16 years later. There was no tumor spreading into the abdominal cavity and pelvis. Full thickness of the abdominal wall resection and coexisting incisional hernia resulted in a large 25x20 cm abdominal wall defect managed by the modified components separation technique and implanting meshes. Conclusion. Major abdominal wall resection and abdominal wall reconstruction using the modified components separation technique reinforced with meshes could be one of possible solutions in the surgical treatment of primary malignant mixed Mullerian tumor localized in the abdominal wall. [Projekat Ministarstva nauke Republike Srbije, br. 41030

  2. Effects of topical bevacizumab application on early bleb failure after trabeculectomy: observational case series

    Directory of Open Access Journals (Sweden)

    Klos-Rola J

    2013-09-01

    Full Text Available Justyna Klos-Rola, Maria Tulidowicz-Bielak, Tomasz Zarnowski Department of Ophthalmology, Medical University of Lublin, Lublin, Poland Background: The aim of this study was to evaluate the influence of topical bevacizumab on the formation and function of filtering blebs in eyes with early bleb failure after antiglaucoma surgery. Methods: Of all patients who underwent mitomycin-augmented trabeculectomy for glaucoma in the Department of Ophthalmology at the Medical University in Lublin, Poland, between March 2009 and March 2010, a total of 21 eyes from 20 patients with injected filtration bleb 9.8 ± 4.7 days after surgery were included in this observational case series. All patients were treated with standard steroid therapy and topical bevacizumab 5 mg/mL five times a day for 20.9 ± 9.8 days. Patients were followed up every other day, and a full eye examination was performed 14, 30, 60, and 180 days after initiation of treatment. Blebs were evaluated for vascularity by slit-lamp examination with concomitant photographic documentation and intraocular pressure measurement. Results: Elevated functional bleb with significantly reduced vascularity was present in 16 eyes, and was flat and nonfunctional in five eyes. Intraocular pressure in all eyes decreased from a mean of 26.6 ± 9.6 mmHg before surgery to 14.6 ± 7.7 mmHg and 15.8 ± 8.3 mmHg at 2 and 6 months after surgery, respectively. Filtration bleb leak was noted in three eyes while on treatment with bevacizumab. Conclusion: Topical application of bevacizumab might favor functional bleb formation after trabeculectomy in eyes with a high risk of failure. Keywords: glaucoma, trabeculectomy, bleb failure, bevacizumab

  3. A case of esophageal so-called carcinosarcoma, which proliferated after radiochemotherapy against squamous cell carcinoma

    International Nuclear Information System (INIS)

    Sasaki, Shozo; Kurosaka, Yoshiyuki; Funaki, Kohziro; Michiwa, Yoshio; Takegawa, Shigeru; Kiriyama, Masato; Kawashima, Atsuhiro; Kojima, Yasuhiko

    2007-01-01

    A 89-year-old woman undergoing fibroptic esophagoscopy elsewhere for dysphagia was found to have an esophageal tumor and was referred to our hospital. Upper gastrointestinal endoscopy showed a type 1 esophageal tumor about 3 cm in diameter in the lower thoracic esophagus pathologically diagnosed as moderately differentiated squamous cell carcinoma from the biopsy specimen. CT and MRI showed metastasis in the right lymph node of cardia. Although we advised an esophagectomy, she did not agree to it due to her high age, so we treated her with radiochemotherapy. She underwent radiotherapy (54 Gy) and chemotherapy (cisplatin and 5-fluorouracil (FU)) concurrently. It was effective and the tumor almost disappeared and the biopsy specimen showed few viable cells. After 12 months, the tumor recurred and the pathological diagnosis was so-called carcinosarcoma. She died 14 months after treatment and pathological autopsy showed the tumor of the esophagus to be so-called carcinosarcoma, but metastasized tissue consisted of squamous cell carcinoma and did not have a sarcoma component. We concluded that metaplastic change of squamous carcinoma cells into spindle cells, occurred due to radiochemotherapy and the tumor recurred as so-called carcinosarcoma. (author)

  4. Bleb incarceration following Ahmed valve surgery

    Directory of Open Access Journals (Sweden)

    Gross FJ

    2016-10-01

    Full Text Available Fredric J Gross, Giovanni DiSandro Department of Ophthalmology, Eastern Virginia Medical School, Norfolk, VA, USA Abstract: Globe luxation is a painful and potentially vision-threatening condition in which the globe becomes trapped behind the eyelids requiring physician intervention in the emergency department or eye clinic. On presentation, the patient typically complains of an inability to close their eye, severe foreign body sensation, decreased vision, and significant eye pain. Although most visual symptoms are reversible and primarily result from exposure keratopathy, optic nerve damage, and permanent vision loss can occur from repeat or prolonged episodes of globe luxation. Risk factors include any congenital or acquired conditions that displace the globe anteriorly in the orbit and increased eyelid laxity that allows the globe to prolapse through the lid aperture. Typically, the precipitating event involves eyelid retraction during ophthalmic examination or an event that increases intraorbital pressure such as coughing or sneezing. Once the globe has luxated, the condition is typically worsened by blepharospasm and patients’ attempts to close the eye that worsen the entrapment. In the current case, the patient had a large superotemporal filtering bleb following Ahmed valve surgery for uncontrolled glaucoma. While instilling her glaucoma medication, she retracted her eyelids sufficiently to pull the upper lid over her filtering bleb where it became entrapped causing a similar presentation to globe luxation. Traditional methods of repositioning the globe were unsuccessful. Bleb needling was ultimately required to return the globe to a normal position. Keywords: luxation, globe, glaucoma

  5. Prognostic value of total lesion glycolysis on preoperative {sup 18}F-FDG PET/CT in patients with uterine carcinosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong-Won [Sungkyunkwan University School of Medicine, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of); Sungkyunkwan University School of Medicine, Samsung Advanced Institute for Health Sciences and Technology, Seoul (Korea, Republic of); Heo, Eun Jin [Sungkyunkwan University School of Medicine, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of); Moon, Seung Hwan [Sungkyunkwan University School of Medicine, Department of Nuclear Medicine, Seoul (Korea, Republic of); Lee, Hyunjong; Cheon, Gi Jeong [Seoul National University College of Medicine, Department of Nuclear Medicine, Seoul (Korea, Republic of); Lee, Maria; Kim, Hee Seung; Chung, Hyun Hoon [Seoul National University College of Medicine, Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul (Korea, Republic of)

    2016-11-15

    To investigate the relationship between functional tumour parameters measured during preoperative {sup 18}F-FDG PET/CT and clinical outcomes in patients with uterine carcinosarcoma. For patients with pathologically proven uterine carcinosarcoma, we determined the maximal and average standardized uptake values, cumulative total lesion glycolysis (TLG) and sum of all metabolic tumour volumes (MTVs). Their predictive value for recurrence and the effects of pretreatment functional tumour activity on patient survival were compared. Clinicopathological data from 28 eligible patients were reviewed. The median duration of progression-free survival was 18.6 months (range 6.1-84.5 months), and 10 (35.7 %) patients experienced recurrences. Univariate analyses showed significant associations between recurrence and tumour size, lymph node metastasis, high TLG and MTV values, and ovarian invasion. Multivariate analysis identified high TLG value as an independent risk factor for recurrence (p = 0.048, hazard ratio 115.261, 95 % confidence interval 1.041-12,765.483). Kaplan-Meier survival curves showed that progression-free survival significantly differed in groups categorized according to TLG (p = 0.007, log-rank test). Preoperative TLG measured with {sup 18}F-FDG PET/CT was statistically significantly associated with uterine carcinosarcoma recurrence. Metabolic parameters can provide useful quantitative criteria for disease prognostication in patients with uterine carcinosarcoma before treatment. (orig.)

  6. Hepcidin as a possible marker in determination of malignancy degree and sensitivity of breast cancer cells to cytostatic drugs.

    Science.gov (United States)

    Yalovenko, T M; Todor, I M; Lukianova, N Y; Chekhun, V F

    2016-06-01

    To investigate the role of hepcidin (Hepc) in the formation of cells malignant phenotype in vitro and its expression in the dyna-mics of growth of Walker-256 carcinosarcoma with different sensitivity to doxorubicin (Dox). The cell lines used in the analysis included T47D, MCF-7, MDA-MB-231, MDA-MB-468, MCF/CP, and MCF/Dox. Hepc expression was studied by immunocytochemical method. "Free" iron content was determined by EPR spectroscopy. Determination of Hepc expression in homogenates of tumor tissue and in blood serum of rats with Dox-sensitive and -resistant Walker-256 carcinosarcoma was performed. It was found that Hepc levels in breast cancer (BC) cells with high degree of malignancy (MDA-MB-231, MDA-MB-468) and drug-resistant phenotype (MCF/CP, MCF/Dox) were by 1.5-2 times higher (p < 0.05) in comparison with sensitive and less malignant BC cells. The development of drug-resistant phenotype in Walker-256 carcinosarcoma cells was accompanied by increasing of Hepc and "free" iron content (by 2.4 and 1.2 times, respectively). The data of in vitro and in vivo research evidenced on involvement of Hepc in formation of BC cells malignant phenotype and their resistance to Dox.

  7. Cellular blebs: pressure-driven, axisymmetric, membrane protrusions

    KAUST Repository

    Woolley, Thomas E.; Gaffney, Eamonn A.; Oliver, James M.; Baker, Ruth E.; Waters, Sarah L.; Goriely, Alain

    2013-01-01

    is physically unrealistic. Thus, the model is extended to include a reconfiguration process that allows large blebs to form with small increases in area. It is observed that both geometric and biomechanical constraints are important in this process

  8. Agile Walker.

    Science.gov (United States)

    Katz, Reuven

    2015-01-01

    The goal of the Agile Walker is to improve the outdoor mobility of healthy elderly people with some mobility limitations. It is a newly developed, all-terrain walker, equipped with an electric drive system and speed control that can assists elderly people to walk outdoors or to hike. The walker has a unique product design with an attractive look that will appeal to "active-agers" population. This paper describes product design requirements and the development process of the Agile Walker, its features and some preliminary testing results.

  9. Hepatocyte membrane injury and bleb formation following low dose comfrey toxicity in rats.

    Science.gov (United States)

    Yeong, M L; Wakefield, S J; Ford, H C

    1993-04-01

    Comfrey, a popular herbal remedy, contains hepatotoxic pyrrolizidine alkaloids and has been implicated in recent human toxicity. Although alkaloids from other plant sources have been extensively researched, studies on the hepatotoxic effects of comfrey alkaloids are scant. The effects of high dose comfrey toxicity have been studied and the present investigation was undertaken to identify changes associated with relatively low dose toxicity. Eight young adult rats were dosed weekly for six weeks with 50 mg/kg of comfrey derived alkaloids. The animals were dissected one week after the last dose and the livers examined by light and electron microscopy. Changes at the light microscopic level showed vascular congestion, mild zone 3 necrosis and loss of definition of hepatocyte cellular membranes. Extensive ultrastructural abnormalities were identified in the form of endothelial sloughing and the loss of hepatocyte microvilli. A striking finding was florid bleb formation on the sinusoidal borders of hepatocytes. Many blebs were shed into the space of Disse and extruded to fill, and sometimes occlude, sinusoidal lumina. Platelets were frequently found in areas of bleb formation. There was evidence of late damage in collagenization of Disse's space. Hepatocyte bleb formation is known to occur under a variety of pathological conditions but there is little to no information in the literature on the effects, if any, of bleb formation on fibrogenesis and the microcirculation and its role in the pathogenesis of liver disease. The pyrrolizidine alkaloids of comfrey may serve as an experimental tool to study the process of bleb formation and the intimate relationship between hepatocyte and sinusoidal injury in the liver.

  10. Pulmonary carcinosarcoma initially presenting as invasive aspergillosis: a case report of previously unreported combination

    Directory of Open Access Journals (Sweden)

    Van Thien

    2010-01-01

    Full Text Available Abstract Carcinosarcoma of the lung is a malignant tumor composed of a mixture of carcinoma and sarcoma elements. The carcinomatous component is most commonly squamous followed by adenocarcinoma. The sarcomatous component commonly comprises the bulk of the tumor and shows poorly differentiated spindle cell features. Foci of differentiated sarcomatous elements such as chondrosarcoma and osteosarcoma may be seen. Aspergillus pneumonia is the most common form of invasive aspergillosis and occurs mainly in patients with malignancy, immunocompromizing or debilitating diseases. Patients with Aspergillus pneumonia present with fever, cough, chest pain and occasionally hemoptysis. Tissue examination is the most reliable method for diagnosis, and mortality rate is high. We describe a case of primary carcinosarcoma of the lung concurrently occurring with invasive pulmonary aspergillosis in a 66-year old patient.

  11. The Advanced Glaucoma Intervention Study (AGIS): 5. Encapsulated bleb after initial trabeculectomy.

    Science.gov (United States)

    Schwartz, A L; Van Veldhuisen, P C; Gaasterland, D E; Ederer, F; Sullivan, E K; Cyrlin, M N

    1999-01-01

    To compare the incidence of encapsulated bleb after trabeculectomy in eyes with and without previous argon laser trabeculoplasty and to assess other risk factors for encapsulated bleb development. After medical treatment failure, eyes enrolled in the Advanced Glaucoma Intervention Study (AGIS) were randomly assigned to sequences of interventions starting with either argon laser trabeculoplasty or trabeculectomy. In the present study we compared the clinical course for 1 year after trabeculectomy in 119 eyes with failed argon laser trabeculoplasty with that of 379 eyes without previous argon laser trabeculoplasty. Data on bleb encapsulation were collected at the time that the encapsulation was diagnosed, and 3 and 6 months later. Of multiple factors examined in the AGIS data for the risk of developing encapsulated bleb, only male gender and high school graduation without further formal education were statistically significant. Encapsulation occurred in 18.5% of eyes with previous argon laser trabeculoplasty failure and 14.5% of eyes without previous argon laser trabeculoplasty (unadjusted relative risk, 1.27; 95% confidence limits = 0.81, 2.00; P = .23). After adjusting for age, gender, educational achievement, prescribed systemic beta-blockers, diabetes, visual field score, and years since glaucoma diagnosis, this difference remains statistically not significant. Four weeks after trabeculectomy, mean intraocular pressure was 7.5 mm Hg higher in eyes with (22.5 mm Hg) than without (15.0 mm Hg) encapsulated bleb; at 1 year after trabeculectomy and the resumption of medical therapy when needed, this excess was reduced to 1.4 mm Hg. This study, as did two previous studies, found male gender to be a risk factor for bleb encapsulation. Four studies, including the present study, have reported a higher rate of encapsulation in eyes with previous argon laser trabeculoplasty; in two of the studies, one of which was the present study, the rate was not statistically

  12. Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography.

    Science.gov (United States)

    Hsu, S Tammy; Gabr, Hesham; Viehland, Christian; Sleiman, Karim; Ngo, Hoan T; Carrasco-Zevallos, Oscar M; Vajzovic, Lejla; McNabb, Ryan P; Stinnett, Sandra S; Izatt, Joseph A; Kuo, Anthony N; Toth, Cynthia A

    2018-04-01

    We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. A MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging an object of known size in model eyes. This method then was applied to subretinal blebs created by injection of diluted triamcinolone. Bleb volumes obtained from MIOCT were compared to the intended injection volume and the surgeon's estimation of leakage. Validation of the image-based volume measurement method showed accuracy to ±1.0 μL (6.0% of measured volume) with no statistically significant variation under different imaging settings. When this method was applied to subretinal blebs, four of 11 blebs without surgeon-observed leakage yielded a mean volume of 32 ± 12.5 μL, in contrast to the intended 50 μL volume injected from the delivery device. This constituted a mean difference of -18 μL (mean percent error, 36 ± 25%). For all 11 blebs, the surgeon's estimations of leakage were significantly different from and showed no correlation with the volume loss based on image-based volume measurements ( P < 0.001, paired t -test; intraclass correlation = 0). We validated an accurate and reproducible method for measuring subretinal volumes using MIOCT. Use of this method revealed that the intended volume might not be delivered into the subretinal space. MIOCT can allow for accurate assessment of subretinal dose delivered, which may have therapeutic implications in evaluating the efficacy and toxicity of subretinal therapies. Use of MIOCT can provide feedback on the accuracy of subretinal injection volumes delivered.

  13. Predictive value of early postoperative IOP and bleb morphology in Mitomycin-C augmented trabeculectomy.

    Science.gov (United States)

    Esfandiari, Hamed; Pakravan, Mohammad; Loewen, Nils A; Yaseri, Mehdi

    2017-01-01

    Background : To determine the predictive value of postoperative bleb morphological features and intraocular pressure (IOP) on the success rate of trabeculectomy. Methods : In this prospective interventional case series, we analyzed for one year 80 consecutive primary open angle glaucoma patients who underwent mitomycin-augmented trabeculectomy. Bleb morphology was scored using the Indiana bleb appearance grading scale (IBAGS). Success was defined as IOP ≤15 mmHg at 12 months. We applied a multivariable regression analysis and determined the area under the receiver operating characteristic curve (AUC). Results : The mean age of participants was 62±12.3 years in the success and 63.2±16.3 years in the failure group (P= 0.430) with equal gender distribution (P=0.911). IOPs on day 1, 7 and 30 were similar in both (P= 0.193, 0.639, and 0.238, respectively.) The AUC of IOP at day 1, day 7 and 30 for predicting a successful outcome was 0.355, 0.452, and 0.80, respectively. The AUC for bleb morphology parameters of bleb height, extension, and vascularization, on day 14 were 0.368, 0.408, and 0.549, respectively. Values for day 30 were 0.428, 0.563, and 0.654. IOP change from day 1 to day 30 was a good predictor of failure (AUC=0.838, 95% CI: 0.704 to 0.971) with a change of more than 3 mmHg predicting failure with a sensitivity of 82.5% (95% CI: 68 to 91%) and a specificity of 87.5% (95% CI: 53 to 98%). Conclusions : IOP on day 30 had a fair to good accuracy while bleb features failed to predict success except bleb vascularity that had a poor to fair accuracy.  An IOP increase more than 3 mmHg during the first 30 days was a good predictor of failure.

  14. Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.

    Science.gov (United States)

    Goudarzi, Mohammad; Tarbashevich, Katsiaryna; Mildner, Karina; Begemann, Isabell; Garcia, Jamie; Paksa, Azadeh; Reichman-Fried, Michal; Mahabaleshwar, Harsha; Blaser, Heiko; Hartwig, Johannes; Zeuschner, Dagmar; Galic, Milos; Bagnat, Michel; Betz, Timo; Raz, Erez

    2017-12-04

    Cell migration is essential for morphogenesis, organ formation, and homeostasis, with relevance for clinical conditions. The migration of primordial germ cells (PGCs) is a useful model for studying this process in the context of the developing embryo. Zebrafish PGC migration depends on the formation of cellular protrusions in form of blebs, a type of protrusion found in various cell types. Here we report on the mechanisms allowing the inflation of the membrane during bleb formation. We show that the rapid expansion of the protrusion depends on membrane invaginations that are localized preferentially at the cell front. The formation of these invaginations requires the function of Cdc42, and their unfolding allows bleb inflation and dynamic cell-shape changes performed by migrating cells. Inhibiting the formation and release of the invaginations strongly interfered with bleb formation, cell motility, and the ability of the cells to reach their target. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Thoracoscopic CO laser coagulation shrinkage of blebs in treatment of spontaneous pneumothorax

    Science.gov (United States)

    Sensaki, Koji; Arai, Tsunenori; Kikuchi, Keiichi; Takagi, Keigo; Tanaka, Susumu; Kikuchi, Makoto

    1992-06-01

    Spontaneous pneumothorax is a common disease in young people. Operative intervention has been done in most of the recurrent cases. Recently thoracoscopic treatment has been tested as a less invasive treatment modarity. We adopted carbon monoxide (CO) laser for thoracoscopic treatment of recurrent spontaneous pneumothorax. CO laser (wavelength; 5.4 micrometers ) could be delivered by chalcogenide glass (As - S) covered with a teflon sheath and ZnSe fiber tip. The sterilized flexible bronchoscope was inserted through the thoracoscopic outer sheath under local anesthesia. Shrinkage of blebs was obtained by non-contact method of CO laser irradiation. Laser power at the tip was 2.5 - 5 W and irradiation duration was 0.5 s each. Excellent shrinkage of bleb and bulla could be obtained by CO laser without perforation complication. Advantages of CO laser as a thoracoscopic treatment were: (1) capability of fiber delivery (flexible thoracoscopy was easy to operate and clear to visualize the blebs which were frequently found at the apical portion of the lung, and (2) shallow extinction length (good shrinkage of blebs, low risk of perforation, and thin layer of carbonization). In conclusion, our new technique of thoracoscopic CO laser irradiation was found to be a safe and effective treatment of spontaneous pneumothorax.

  16. Experimental model of ultrasound thermotherapy in rats inoculated with Walker-236 tumor Modelo experimental de termoterapia ultrassônica em ratos inoculados com tumor de Walker-236

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    José Antonio Carlos Otaviano David Morano

    2011-01-01

    Full Text Available PURPOSE: To develop a model to evaluate the effects of focal pulsed ultrasound (US waves as a source of heat for treatment of murine subcutaneous implanted Walker tumor. METHODS: An experimental, controlled, comparative study was conducted. Twenty male Wistar rats (160-300 g randomized in 2 equal groups (G-1: Control and G-2: Hyperthermia were inoculated with Walker-256 carcinosarcoma tumor. After 5 days G-2 rats were submitted to 45ºC hyperthermia. Heat was delivered directly to the tumor by an ultrasound (US equipment (3 MHz frequency, 1,5W/cm³. Tumor temperature reached 45º C in 3 minutes and was maintained at this level for 5 minutes. Tumor volume was measured on days 5, 8, 11, 14 e 17 post inoculation in both groups. Unpaired t-test was used for comparison. POBJETIVO: Desenvolver um modelo para avaliar os efeitos do ultra-som focal pulsado como fonte de calor para o tratamento de tumores de Walker subcutâneos implantados em ratos. MÉTODOS: Um estudo experimental, controlado, comparativo foi realizado. Vinte ratos Wistar machos (160-300 g divididos em dois grupos (G-1: Controle e G-2: hipertermia foram inoculados com tumor de Walker carcinossarcoma-256. Após cinco dias os ratos do grupo G-2 ratos foram submetidos a hipertermia (45ºC. O calor foi aplicado diretamente no tumor por um equipamento de ultrassonografia (3 MHz, 1,5 W/cm³. A temperatura no tumor atingiu 45ºC em 3 minutos e foi mantida nesse nível por 5 minutos. O volume do tumor foi medido nos dias 5, 8, 11, 14 e 17 após a inoculação, em ambos os grupos. Teste t não pareado foi utilizado para comparação. P <0,05 foi considerado significante. RESULTADOS: O volume do tumor foi significativamente maior no 5º dia e diminuiu nos dias 11, 14 e 17 nos ratos tratados. Animais submetidos à hipertermia sobreviveram mais tempo que os animais do grupo controle. No 29º dia após a inoculação do tumor, 40% dos ratos do grupo controle e 77,78% dos ratos tratados com

  17. A Case of Undesired Bleb Developed After Penetrating Injury

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    Cem Ozgonul

    2014-03-01

    Full Text Available Eighty-year-old male patient was admitted to our policlinic with stinging, burning and itching in both eyes. Ophthalmological examination revealed avascular undesired bleb that releated with anterior chamber at 2-3 hour quadrant nasal limbus with the surrounding corneal and conjunctival epithelium was vascularized and the dimension was 3x3x3 mm. Towards these findings, we questioned the patient again and we found that, 40 years ago, a broken part of the shaving razor had injured his eye. After penetrating injury of the eye, because of the sutured wound leakage, undesired bleb formations can be seen. We suggest that kind of patient shold be followed up to prevent late complications of penetrating injury.

  18. Vicious random walkers in the limit of a large number of walkers

    International Nuclear Information System (INIS)

    Forrester, P.J.

    1989-01-01

    The vicious random walker problem on a line is studied in the limit of a large number of walkers. The multidimensional integral representing the probability that the p walkers will survive a time t (denoted P t (p) ) is shown to be analogous to the partition function of a particular one-component Coulomb gas. By assuming the existence of the thermodynamic limit for the Coulomb gas, one can deduce asymptotic formulas for P t (p) in the large-p, large-t limit. A straightforward analysis gives rigorous asymptotic formulas for the probability that after a time t the walkers are in their initial configuration (this event is termed a reunion). Consequently, asymptotic formulas for the conditional probability of a reunion, given that all walkers survive, are derived. Also, an asymptotic formula for the conditional probability density that any walker will arrive at a particular point in time t, given that all p walkers survive, is calculated in the limit t >> p

  19. Excisional Bleb Revision for Management of Failed Ahmed Glaucoma Valve.

    Science.gov (United States)

    Eslami, Yadollah; Fakhraie, Ghasem; Moghimi, Sasan; Zarei, Reza; Mohammadi, Masoud; Nabavi, Amin; Yaseri, Mehdi; Izadi, Ali

    2017-12-01

    To evaluate the outcome of excisonal bleb revision in patients with failed Ahmed glaucoma valve (AGV). In total, 29 patients with uncontrolled intraocular pressure (IOP) despite of maximal tolerated medical therapy at least 6 months after AGV implantation were enrolled in this prospective interventional case series. Excision of fibrotic tissue around the reservoir with application of mitomycin C 0.02% was performed. IOP, number of glaucoma medications were evaluated at baseline and 1 week and 1, 3, 6, and 12 months postoperatively. Complete and qualified success was defined as IOP≤21 mm Hg with or without glaucoma medications, respectively. Intraoperative and postopervative complications were also recorded. Mean IOP was reduced from 30±4.2 mm Hg at baseline to 19.2±3.1 mm Hg at 12-month follow-up visit (Pglaucoma medications was decrease from 3.2±0.5 at baseline to 1.9±0.7 at 12-month follow-up (Pglaucoma surgeries were significantly associated with the failure of excisonal bleb revision. Excisional bleb revision could be considered as a relatively effective alternative option for management of inadequate IOP control after AGV implantation.

  20. An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells.

    Science.gov (United States)

    Lorentzen, Anna; Bamber, Jeffrey; Sadok, Amine; Elson-Schwab, Ilan; Marshall, Christopher J

    2011-04-15

    Melanoma cells can switch between an elongated mesenchymal-type and a rounded amoeboid-type migration mode. The rounded 'amoeboid' form of cell movement is driven by actomyosin contractility resulting in membrane blebbing. Unlike elongated A375 melanoma cells, rounded A375 cells do not display any obvious morphological front-back polarisation, although polarisation is thought to be a prerequisite for cell movement. We show that blebbing A375 cells are polarised, with ezrin (a linker between the plasma membrane and actin cytoskeleton), F-actin, myosin light chain, plasma membrane, phosphatidylinositol (4,5)-bisphosphate and β1-integrin accumulating at the cell rear in a uropod-like structure. This structure does not have the typical protruding shape of classical leukocyte uropods, but, as for those structures, it is regulated by protein kinase C. We show that the ezrin-rich uropod-like structure (ERULS) is an inherent feature of polarised A375 cells and not a consequence of cell migration, and is necessary for cell invasion. Furthermore, we demonstrate that membrane blebbing is reduced at this site, leading to a model in which the rigid ezrin-containing structure determines the direction of a moving cell through localised inhibition of membrane blebbing.

  1. Utility of bleb imaging with anterior segment optical coherence tomography in clinical decision-making after trabeculectomy.

    Science.gov (United States)

    Singh, Mandeep; Aung, Tin; Aquino, Maria C; Chew, Paul T K

    2009-08-01

    To determine if imaging of blebs with anterior segment optical coherence tomography (ASOCT) affects clinical decision-making with regard to laser suture lysis (LSL) after trabeculectomy. In this prospective observational case series, we included patients with poorly controlled intraocular pressure (IOP) after standardized trabeculectomy from May to November 2006. One observer assessed IOP, anterior chamber depth and bleb formation, and recorded a decision of whether or not to undertake LSL based on clinical grounds. A second observer masked to clinical data recorded a decision of whether or not to perform LSL based on ASOCT assessment of scleral flap position, presence of a sub-flap space, patency of the internal ostium, and bleb wall thickening. We compared the 2 observers' decisions to determine how ASOCT influenced decision-making. Seven eyes of 7 patients were included. On the basis of clinical examination, LSL was recommended in all 7 (100.0%) cases due to presence of elevated IOP, deep anterior chambers and poorly formed blebs. Using ASOCT, LSL was recommended in 5/7 (71.4%) cases with apposed scleral flaps, absent sub-flap spaces, and absent bleb wall thickening. In 2/7 (28.7%) cases, LSL was not recommended based on ASOCT findings of an elevated scleral flap, a patent sub-flap space, and bleb wall thickening. All 7 patients had good IOP control and formed blebs at a mean of 8.4+/-2.6 months after trabeculectomy, with a mean IOP of 14.3+/-3.2 mm Hg with no medications. This small study suggests that ASOCT imaging may affect decision-making with regard to LSL by providing information not apparent on clinical examination.

  2. A rare case of anal carcinosarcoma with human papilloma virus infection in both biphasic tumor elements: An immunohistochemical, molecular and ultrastructural study

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    Richard A. Hickman

    2016-12-01

    Full Text Available Carcinosarcoma of the anus is rare and has yet to be reportedly associated with the keratinocyte-specific Human Papilloma Virus (HPV. We describe a case of anal carcinosarcoma with HPV infection in both the epithelial and mesenchymal components of the tumor by immunohistochemistry, chromogenic in-situ hybridization (CISH and further supported by electron microscopy (EM. Microscopic examination of the tumor showed nests of poorly-differentiated invasive squamous cell carcinoma with basaloid features intermixed with a hypercellular, atypical spindle cell proliferation. Immunohistochemistry demonstrated that the epithelial component was positive for AE1/AE3, p63, CK5/6 and p16, whilst the mesenchymal component was positive for smooth muscle actin, vimentin, and focally positive for desmin and p16, consistent with carcinosarcoma. The tumor was negative for GATA-3, CK7 and CK20. CISH demonstrated that the tumor was positive for high risk HPV (subtype 16/18 in both tumor components. EM further supported the presence of intracellular virus particles (~50 nm that is compatible with HPV infection. Infection of both epithelial and mesenchymal tumor components by HPV has not been previously observed in the gastrointestinal tract. This finding may represent initial epithelial HPV infection with subsequent divergent tumoral differentiation and suggests the presence of viral replication in both biphasic tumor components. Keywords: Carcinosarcoma, Human Papilloma Virus, Gastrointestinal

  3. Mature Teratoma Associated with Bilateral Ovarian Carcinosarcoma - Accidental Association or Etiopathogenetic Determinism? - Case Report.

    Science.gov (United States)

    Birla, Rodica; Catanescu, Elena-Roxana; Caragui, Andrei; Constantinoiu, Silviu

    2016-01-01

    Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113.7 mg / dl, serum total proteins = 8.65 g / dl, the albumin / globulin subunit, CRP 33.63 mg / l, sideremia 51 ug / dl, CA 125 = 588.4 IU. Abdominal ultrasound: high volume fluid and multiple perihepatic formations and multiple formations with cystic transformation in the abdomen and pelvis. CT exam describes multiple tissular masses localized intraperitoneal in the abdominal-pelvic region, sheath fluid effusion, infiltrative, with mass effect on the digestive lumens, without visible CT obstruction. Surgical treatment consisted in evacuation of the ascites fluid, excision of the tumoral lumps situated in the great omentum, omentectomy, excision of the lumps of the gastrocolic ligament, bilateral ovariectomy and hysterectomy. Postoperative simple evolution. Histopathology confirmed the diagnosis of bilateral ovarian carcinosarcoma associated with tridermic mature teratoma (presence of brain tissue areas associated with cartilage, transitional type epithelium, tubal type epithelium, endometrial stroma type and fatty tissue). IHC confirms the compatibility with the diagnosis of ovarian carcinosarcoma (mixed malignant Mullerian tumor). The patient followed adjuvant polichemotherapy. The association of teratoma with carcinosarcomatoase elements confers a poor prognosis case. Celsius.

  4. Clinical observation of needle revision and 5-fluorouracil subconjunctive injection for the dysfunctional filtering blebs

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    Yan-Hua Gao

    2016-07-01

    Full Text Available AIM:To investigate the efficacy and safety of needle revision with 5-fluorouracil(5-FUon the dysfunctional filtering blebs after trabeculectomy and to assess the factors that may impact the success. METHODS:Eighty-three eyes in 76 patients underwent the needle revision and 5-FU subconjunctive injection for the dysfunctional blebs after trabeculectomy and were followed up for 12mo. The intraocular pressure(IOP, the number of drugs, corneal endothclium, bleb morphology and complications were observed and recorded. RESULTS:IOP decreased significantly from 35.3±5.8mmHg(1kPa=7.5mmHgof pre-needling to 17.0±4.3mmHg of post-needling(PPCI: 10.3-11.6. Statistically, there were no significant difference on needling effect with reference to the types of glaucoma, the use of mitomycin C(MMCduring the previous filtration surgery, the ages of patients, the intervals of needling operation from previous trabeculectomy, while there were significant difference on needling effect with reference to bleb appearance before needling, and the mean number of needling in patients that had surgery within 3mo were less than those who had surgery for more than 3mo. CONCLUSION: The needle revision combined with 5-FU is a safe, effective and simple method. Dysfunctional blebs should be treated early after trabeculectomy.

  5. Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus.

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    Mohanan Valiya Veettil

    2010-12-01

    Full Text Available KSHV is etiologically associated with Kaposi's sarcoma (KS, an angioproliferative endothelial cell malignancy. Macropinocytosis is the predominant mode of in vitro entry of KSHV into its natural target cells, human dermal microvascular endothelial (HMVEC-d cells. Although macropinocytosis is known to be a major route of entry for many viruses, the molecule(s involved in the recruitment and integration of signaling early during macropinosome formation is less well studied. Here we demonstrate that tyrosine phosphorylation of the adaptor protein c-Cbl is required for KSHV induced membrane blebbing and macropinocytosis. KSHV induced the tyrosine phosphorylation of c-Cbl as early as 1 min post-infection and was recruited to the sites of bleb formation. Infection also led to an increase in the interaction of c-Cbl with PI3-K p85 in a time dependent manner. c-Cbl shRNA decreased the formation of KSHV induced membrane blebs and macropinocytosis as well as virus entry. Immunoprecipitation of c-Cbl followed by mass spectrometry identified the interaction of c-Cbl with a novel molecular partner, non-muscle myosin heavy chain IIA (myosin IIA, in bleb associated macropinocytosis. Phosphorylated c-Cbl colocalized with phospho-myosin light chain II in the interior of blebs of infected cells and this interaction was abolished by c-Cbl shRNA. Studies with the myosin II inhibitor blebbistatin demonstrated that myosin IIA is a biologically significant component of the c-Cbl signaling pathway and c-Cbl plays a new role in the recruitment of myosin IIA to the blebs during KSHV infection. Myosin II associates with actin in KSHV induced blebs and the absence of actin and myosin ubiquitination in c-Cbl ShRNA cells suggested that c-Cbl is also responsible for the ubiquitination of these proteins in the infected cells. This is the first study demonstrating the role of c-Cbl in viral entry as well as macropinocytosis, and provides the evidence that a signaling complex

  6. Feasibility analysis of Triptolide's role in treating filtering bleb fibrosis after the filtration surgery of glaucoma

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    Ting Chen

    2014-06-01

    Full Text Available At present, filtration surgery remains an important treatment of glaucoma, and filtering bleb fibrosis is the main cause for treatment failure. Filtering bleb fibrosis is a common fiber hyperplastic disease, and it relates to the activation and proliferation of fibroblasts and the excessive production of extracellular matrix(ECMsuch as collagen protein. The most frequently-used drugs for filtering bleb fibrosis in clinic are 5-fluoro-2,4(1h, 3hpyrimidinedione(5-Fuand mitomycin(MMC. Although they are effective in some degree, they also have some serious side effects which restrict their clinical use. Triptolide(TPLis a major active component of the medicinal plant, tripterygium wilfordii hook.f.(TWHF. TPL has multiple pharmacological activities including immunosuppressive, anti-inflammatory, anti-cancer and anti-fertility activity. Reviewing related literatures published in recent ten years, we confirmed that TPL seemed to possess a pharmacological activity in treating filtering bleb fibrosis. Since it has three major functions: 1. inhibit the activation and proliferation of fibroblasts and the excessive production of collagen protein; 2. alleviate the inflammatory reaction after surgical wound to suppress fibrous scar formation; 3.TPL has a protective effect on retinal ganglion cells(RGCs. We further find that TPL's anti-fibrosis activity mainly results from that it inhibits TGF-β/Smad,NF-κB and PI3K/AKT signal transduction pathway. This comprehensive analysis about the feasibility of Triptolide's role in treating filtering bleb fibrosis after the filtration surgery of glaucoma can help us develop new drugs for filtering bleb fibrosis and exploit TPL's clinical value on some level.

  7. Blue rubber bleb nevus syndrome: case report Síndrome do blue rubber bleb nevus: relato de caso

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    Magaly Gemio Teixeira

    2003-01-01

    Full Text Available The case of a patient with blue rubber bleb nevus syndrome who is infected by acquired immunodeficiency syndrome virus due to multiple blood transfusions is presented. This case shows that although it is a rare systemic disorder, blue rubber bleb nevus syndrome has to be considered in the differential diagnosis of chronic anemia or gastrointestinal bleeding. Patients should be investigated by endoscopy, which is the most reliable method for detecting these lesions. The patient underwent gastroscopy and enteroscopy via enterotomy with identification of all lesions. Minimal resection of the larger lesions and string-purse suture of the smaller ones involving all the layers of the intestine were performed. The string-purse suture of the lesions detected by enteroscopy proved to be an effective technique for handling these lesions, avoiding extensive intestinal resection and stopping the bleeding. Effective management of these patients demands aggressive treatment and should be initiated as soon as possible to avoid risks involved in blood transfusions, as occurred in this case.É descrito um caso da síndrome do blue rubber bleb nevus associada a infecção pelo vírus da imunodeficiência adquirida em conseqüência de múltiplas transfusões de sangue. Este caso demonstra que, embora rara, esta síndrome deva ser considerada no diagnóstico diferencial da anemia crônica ou sangramento gastrointestinal. O melhor método diagnóstico é a endoscopia. A doente foi operada e submetida a esofagogastroduodenoscopia e endoscopia através de enterotomia com identificação de todas as lesões que foram tratadas, as maiores, por ressecção mínima e as demais por sutura em bolsa ao redor do nevo interessando toda a parede intestinal. A sutura em bolsa das lesões detectadas por enteroscopia demonstrou ser uma técnica efetiva no tratamento destas lesões, evitando assim ressecções intestinais extensas e parando o sangramento. O manuseio destes doentes

  8. Comparative study of encapsulated blebs following Ahmed glaucoma valve implantation and trabeculectomy with mitomycin-C.

    Science.gov (United States)

    Bae, Kunho; Suh, Wool; Kee, Changwon

    2012-08-01

    To compare the histopathologic and morphologic findings of encapsulated blebs following Ahmed glaucoma valve implantation and primary standard trabeculectomy with mitomycin-C. We reviewed the records of patients with otherwise uncontrollable glaucoma who had undergone Ahmed glaucoma valve implantation or trabeculectomy with mitomycin-C. Five eyes that underwent Ahmed valve implantation and three eyes that underwent trabeculectomy needed surgical revision of the initial surgery due to encapsulated bleb development with total loss of function. The surgically removed encapsulated blebs were analyzed macroscopically and microscopically. Removal of the encapsulated bleb was performed at a mean follow-up time of 26.6 ± 19.4 weeks in the Ahmed valve implantation group and 12.0 ± 11.4 weeks in the trabeculectomy group. The fibrotic wall of the encapsulated blebs had an overall thickness of 2.48 ± 0.42 mm in the Ahmed valve implantation group and 1.62 ± 0.37 mm in the trabeculectomy group. Macroscopically, the coconut flesh-like smooth surface was split into two layers, and the wall of the capsule was thicker in the Ahmed valve implantation group than in the trabeculectomy group. Histopathologically, the fibrotic capsule was composed of an inner fibrodegenerative layer and an outer fibrovascular layer, and there were no histopathological differences between the two groups. The fibrotic capsule wall was thicker in the Ahmed valve group, but there were no differences in histological findings between the two groups.

  9. Force spectroscopy measurements show that cortical neurons exposed to excitotoxic agonists stiffen before showing evidence of bleb damage.

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    Shan Zou

    Full Text Available In ischemic and traumatic brain injury, hyperactivated glutamate (N-methyl-D-aspartic acid, NMDA and sodium (Nav channels trigger excitotoxic neuron death. Na(+, Ca(++ and H2O influx into affected neurons elicits swelling (increased cell volume and pathological blebbing (disassociation of the plasma membrane's bilayer from its spectrin-actomyosin matrix. Though usually conflated in injured tissue, cell swelling and blebbing are distinct processes. Around an injury core, salvageable neurons could be mildly swollen without yet having suffered the bleb-type membrane damage that, by rendering channels leaky and pumps dysfunctional, exacerbates the excitotoxic positive feedback spiral. Recognizing when neuronal inflation signifies non-lethal osmotic swelling versus blebbing should further efforts to salvage injury-penumbra neurons. To assess whether the mechanical properties of osmotically-swollen versus excitotoxically-blebbing neurons might be cytomechanically distinguishable, we measured cortical neuron elasticity (gauged via atomic force microscopy (AFM-based force spectroscopy upon brief exposure to hypotonicity or to excitotoxic agonists (glutamate and Nav channel activators, NMDA and veratridine. Though unperturbed by solution exchange per se, elasticity increased abruptly with hypotonicity, with NMDA and with veratridine. Neurons then invariably softened towards or below the pre-treatment level, sometimes starting before the washout. The initial channel-mediated stiffening bespeaks an abrupt elevation of hydrostatic pressure linked to NMDA or Nav channel-mediated ion/H2O fluxes, together with increased [Ca(++]int-mediated submembrane actomyosin contractility. The subsequent softening to below-control levels is consistent with the onset of a lethal level of bleb damage. These findings indicate that dissection/identification of molecular events during the excitotoxic transition from stiff/swollen to soft/blebbing is warranted and should be

  10. Long-term effects of short-term retinal bleb detachments in rabbits.

    Science.gov (United States)

    Ivert, Lena; Kjeldbye, Hild; Gouras, Peter

    2002-03-01

    To examine the effects of saline-induced bleb detachments in rabbit retina. Retinal bleb detachments were produced by the injection of 50 microl of balanced salt solution (BSS) into the subretinal space of one eye of each of six rabbits using a glass pipette with a flat tip, 50 microm in diameter. The retina was examined by biomicroscopy, scanning laser ophthalmoscopy (SLO), auto-fluorescence and simultaneous fluorescein and indocyanine green (ICG) angiography. Histological examination was carried out at 1, 2, 3 and 4 months after surgery. All rabbits showed leakage of fluorescein for at least a day after detachment, but within 1 month the leakage ceased. ICG staining developed gradually at the level of the RPE or Bruch's membrane near sites of previous staining. Lipofuscin fluorescence also developed gradually around areas of staining. Histology revealed the source of the excessive lipofuscin to be in the RPE layer, especially in cells migrating away from Bruch's membrane. Short-term bleb detachments cause a transient breakdown in the blood-retinal barrier, long-term ICG staining at or deep to the RPE layer, hyperlipofuscinosis and migration of the RPE. The abnormal lipofuscin accumulation is apparent on fluorescence ophthalmoscopy and can be confused with markers such as green fluorescent protein.

  11. ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy.

    Science.gov (United States)

    Rothschild, Pierre-Raphaël; Salah, Sawsen; Berdugo, Marianne; Gélizé, Emmanuelle; Delaunay, Kimberley; Naud, Marie-Christine; Klein, Christophe; Moulin, Alexandre; Savoldelli, Michèle; Bergin, Ciara; Jeanny, Jean-Claude; Jonet, Laurent; Arsenijevic, Yvan; Behar-Cohen, Francine; Crisanti, Patricia

    2017-08-18

    In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic regulation and cell polarity is activated by hyperglycemia. In one year-old Goto Kakizaki (GK) type 2 diabetic rats retina, ROCK-1 activation was assessed by its cellular distribution and by phosphorylation of its substrates, MYPT1 and MLC. In both GK rat and in human type 2 diabetic retinas, ROCK-1 is activated and associated with non-apoptotic membrane blebbing in retinal vessels and in retinal pigment epithelium (RPE) that respectively form the inner and the outer barriers. Activation of ROCK-1 induces focal vascular constrictions, endoluminal blebbing and subsequent retinal hypoxia. In RPE cells, actin cytoskeleton remodeling and membrane blebs in RPE cells contributes to outer barrier breakdown. Intraocular injection of fasudil, significantly reduces both retinal hypoxia and RPE barrier breakdown. Diabetes-induced cell blebbing may contribute to ischemic maculopathy and represent an intervention target.

  12. Water Budgets of the Walker River Basin and Walker Lake, California and Nevada

    Science.gov (United States)

    Lopes, Thomas J.; Allander, Kip K.

    2009-01-01

    The Walker River is the main source of inflow to Walker Lake, a closed-basin lake in west-central Nevada. The only outflow from Walker Lake is evaporation from the lake surface. Between 1882 and 2008, upstream agricultural diversions resulted in a lake-level decline of more than 150 feet and storage loss of 7,400,000 acre-feet. Evaporative concentration increased dissolved solids from 2,500 to 17,000 milligrams per liter. The increase in salinity threatens the survival of the Lahontan cutthroat trout, a native species listed as threatened under the Endangered Species Act. This report describes streamflow in the Walker River basin and an updated water budget of Walker Lake with emphasis on the lower Walker River basin downstream from Wabuska, Nevada. Water budgets are based on average annual flows for a 30-year period (1971-2000). Total surface-water inflow to the upper Walker River basin upstream from Wabuska was estimated to be 387,000 acre-feet per year (acre-ft/yr). About 223,000 acre-ft/yr (58 percent) is from the West Fork of the Walker River; 145,000 acre-ft/yr (37 percent) is from the East Fork of the Walker River; 17,000 acre-ft/yr (4 percent) is from the Sweetwater Range; and 2,000 acre-ft/yr (less than 1 percent) is from the Bodie Mountains, Pine Grove Hills, and western Wassuk Range. Outflow from the upper Walker River basin is 138,000 acre-ft/yr at Wabuska. About 249,000 acre-ft/yr (64 percent) of inflow is diverted for irrigation, transpired by riparian vegetation, evaporates from lakes and reservoirs, and recharges alluvial aquifers. Stream losses in Antelope, Smith, and Bridgeport Valleys are due to evaporation from reservoirs and agricultural diversions with negligible stream infiltration or riparian evapotranspiration. Diversion rates in Antelope and Smith Valleys were estimated to be 3.0 feet per year (ft/yr) in each valley. Irrigated fields receive an additional 0.8 ft of precipitation, groundwater pumpage, or both for a total applied-water rate

  13. Generation of micronuclei during interphase by coupling between cytoplasmic membrane blebbing and nuclear budding.

    Directory of Open Access Journals (Sweden)

    Koh-ichi Utani

    Full Text Available Micronucleation, mediated by interphase nuclear budding, has been repeatedly suggested, but the process is still enigmatic. In the present study, we confirmed the previous observation that there are lamin B1-negative micronuclei in addition to the positive ones. A large cytoplasmic bleb was found to frequently entrap lamin B1-negative micronuclei, which were connected to the nucleus by a thin chromatin stalk. At the bottom of the stalk, the nuclear lamin B1 structure appeared broken. Chromatin extrusion through lamina breaks has been referred to as herniation or a blister of the nucleus, and has been observed after the expression of viral proteins. A cell line in which extrachromosomal double minutes and lamin B1 protein were simultaneously visualized in different colors in live cells was established. By using these cells, time-lapse microscopy revealed that cytoplasmic membrane blebbing occurred simultaneously with the extrusion of nuclear content, which generated lamin B1-negative micronuclei during interphase. Furthermore, activation of cytoplasmic membrane blebbing by the addition of fresh serum or camptothecin induced nuclear budding within 1 to 10 minutes, which suggested that blebbing might be the cause of the budding. After the induction of blebbing, the frequency of lamin-negative micronuclei increased. The budding was most frequent during S phase and more efficiently entrapped small extrachromosomal chromatin than the large chromosome arm. Based on these results, we suggest a novel mechanism in which cytoplasmic membrane dynamics pulls the chromatin out of the nucleus through the lamina break. Evidence for such a mechanism was obtained in certain cancer cell lines including human COLO 320 and HeLa. The mechanism could significantly perturb the genome and influence cancer cell phenotypes.

  14. The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.

    Science.gov (United States)

    Hannemann, Sebastian; Madrid, Ricardo; Stastna, Jana; Kitzing, Thomas; Gasteier, Judith; Schönichen, André; Bouchet, Jerome; Jimenez, Alberto; Geyer, Matthias; Grosse, Robert; Benichou, Serge; Fackler, Oliver T

    2008-10-10

    Diaphanous-related formins (DRFs) mediate GTPase-triggered actin rearrangements to regulate central cellular processes, such as cell motility and cytokinesis. The DRF FHOD1 interacts with the Rho-GTPase Rac1 and mediates formation of actin stress fibers in its deregulated form; the physiologically relevant activities and molecular mechanisms of endogenous FHOD1, however, are still unknown. Here we report that FHOD1 physically associates via the N-terminal part of its FH2 domain with the central domain of ROCK1. Although FHOD1 does not affect the kinase activity of ROCK1, the DRF is an efficient substrate for phosphorylation by ROCK1. Co-expression of FHOD1 and ROCK1 results in the generation of nonapoptotic plasma membrane (PM) blebs, to which the DRF is efficiently recruited. Blebbing induced by FHOD1 and ROCK1 depends on F-actin integrity, the Rho-ROCK cascade, and Src activity and is reminiscent of the recently described PM blebs triggered by expression of Src homology 4 (SH4) domain PM targeting signals. Consistently, endogenous FHOD1 is required in SH4 domain expressing cells for efficient PM blebbing and rounded cell morphology in two-dimensional cultures or three-dimensional matrices, respectively. Efficient association of FHOD1 with ROCK1, as well as recruitment of the DRF to blebs, depends on Src activity, suggesting that the functional interaction between both proteins is regulated by Src. These results define a role for endogenous FHOD1 in SH4 domain-induced blebbing and suggest that its activity is regulated by ROCK1 in a Src-dependent manner.

  15. Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes.

    Science.gov (United States)

    Bi, Xiu-Zeng; Pan, Wei-Hua; Yu, Xin-Ping; Song, Zong-Ming; Ren, Zeng-Jin; Sun, Min; Li, Cong-Hui; Nan, Kai-Hui

    2015-01-01

    This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes. Eighteen New Zealand white rabbits were randomly divided into three groups (A, B and C; n = 6 per group). Group A received combined 5-Fu-polycaprolactone sustained-release film application and Ahmed glaucoma valve implantation, group B received local infiltration of 5-Fu and Ahmed glaucoma valve implantation, and group C received Ahmed glaucoma valve implantation. Postoperative observations were made of the anterior segment, intraocular pressure, central anterior chamber depth, blebs, drainage tube, and accompanying ciliary body detachment. The pathology of the blebs and surrounding tissues were observed at month 3 postoperatively. We revealed that the 5-Fu-polycaprolactone sustained-release film maintained a release concentration range of 13.7 ± 0.12 to 37.41 ± 0.47 μg/ml over three months in vitro. Postoperatively, diffuse blebs with ridges were found in all eyes in group A, two blebs were observed in group B, and no bleb formation was present in group C. The postoperative central anterior chamber depth in group A was significantly less than that of the other two groups. The postoperative intraocular pressure of group A stabilized at 6.33-8.67 mmHg, whereas that of group C gradually remained at 7.55-10.02 mmHg. The histopathology showed that the fibrous tissue thickness of the blebs in group A was significantly thinner than that of the other groups. We conclude that the 5-Fu-polycaprolactone sustained-release film had a sustained drug release effect, which promoted the inhibition of bleb scarring after Ahmed glaucoma valve implantation.

  16. Computer simulation of cytoskeleton-induced blebbing in lipid membranes

    DEFF Research Database (Denmark)

    Spangler, E. J.; Harvey, C. W.; Revalee, J. D.

    2011-01-01

    for large values of the ratio between the areas of the bilayer and the cytoskeleton. We also found that blebbing can be induced when the cytoskeleton is subject to a localized ablation or a uniform compression. The results obtained are qualitatively in agreement with the experimental evidence and the model...

  17. Predictive value of early postoperative IOP and bleb morphology in Mitomycin-C augmented trabeculectomy [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Hamed Esfandiari

    2017-12-01

    Full Text Available Background: To determine the predictive value of postoperative bleb morphological features and intraocular pressure (IOP on the success rate of trabeculectomy. Methods: In this prospective interventional case series, we analyzed for one year 80 consecutive primary open angle glaucoma patients who underwent mitomycin-augmented trabeculectomy. Bleb morphology was scored using the Indiana bleb appearance grading scale (IBAGS. Success was defined as IOP ≤15 mmHg at 12 months. We applied a multivariable regression analysis and determined the area under the receiver operating characteristic curve (AUC. Results: The mean age of participants was 62±12.3 years in the success and 63.2±16.3 years in the failure group (P= 0.430 with equal gender distribution (P=0.911. IOPs on day 1, 7 and 30 were similar in both (P= 0.193, 0.639, and 0.238, respectively. The AUC of IOP at day 1, day 7 and 30 for predicting a successful outcome was 0.355, 0.452, and 0.80, respectively. The AUC for bleb morphology parameters of bleb height, extension, and vascularization, on day 14 were 0.368, 0.408, and 0.549, respectively. Values for day 30 were 0.428, 0.563, and 0.654. IOP change from day 1 to day 30 was a good predictor of failure (AUC=0.838, 95% CI: 0.704 to 0.971 with a change of more than 3 mmHg predicting failure with a sensitivity of 82.5% (95% CI: 68 to 91% and a specificity of 87.5% (95% CI: 53 to 98%. Conclusions: IOP on day 30 had a fair to good accuracy while bleb features failed to predict success except bleb vascularity that had a poor to fair accuracy.  An IOP increase more than 3 mmHg during the first 30 days was a good predictor of failure.

  18. Management of the late leaking filtration blebs. A report of seven cases and a selective review of the literature.

    Directory of Open Access Journals (Sweden)

    Mandal A

    2001-01-01

    Full Text Available PURPOSE: To describe the outcome of various treatment modalities in the management of late bleb leaks after glaucoma filtering surgery (GFS. MATERIALS AND METHODS: Seven consecutive patients treated for late bleb leaks (Seidel′s positive between July 1990 and June 1999 were were enrolled in the study. The management strategy consisted of initial conservative therapy, and tailored surgery, if necessary. The surgical technique employed was either conjunctival-Tenon′s advancement flap, hinged scleral flap, or fistulectomy with direct suturing. The main outcome measures were bleb characteristics and postoperative intraocular pressure (IOP. The secondary outcome measure was visual acuity. RESULTS: One patient responded to conservative therapy (aqueous suppressants, bandage contact lens and six patients needed surgery. The successful surgical technique was conjunctivo-Tenon′s advancement flap in three, hinged scleral flap in two, and fistulectomy-direct suturing to the wound (combined with cataract surgery and intraocular lens implantation in one patient. The bleb leak stopped in all cases and 5 of the 6 surgical patients sustained functioning filtering blebs. Follow-up ranged from 8 to 56 months (mean = 20.4 +/- 16.2 months. Visual acuity improved to 6/12 or better in 4 cases, 6/36 in 2 cases and it remained at light perception in one case. None of the patients had any intraoperative or postoperative complications. CONCLUSIONS: Late leaking blebs after GFS can be treated successfully. The management decision and selection of surgical technique should be based on the clinical condition.

  19. Palladium-103 plaque radiation therapy for ciliary body melanoma through a functioning glaucoma filtering bleb.

    Science.gov (United States)

    Pathan, Arif H K; Barash, Alexander; Tena, Lawrence B; Finger, Paul T

    2018-01-01

    To provide a clinical description of the long-term outcome of a 103 Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb. A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a 103 Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. At plaque insertion, amniotic membrane grafts were used to cover the plaque and protect the filtering site. The tumor was successfully treated without clinical evidence of harm to the filtering bleb, with resultant stable intraocular pressure. However, the patient developed blebitis 1.5 years later. Though it resolved with topical antibiotic therapy, the bleb became less succulent. Two years postoperatively, she developed a spontaneous hyphema that resolved after one injection of transscleral bevacizumab 1.25 mg. Her tumor continually regressed in thickness. Without additional glaucoma surgery, her intraocular pressure remained well-controlled on topical medications for 6 years. Ciliary body melanoma with minimal extrascleral extension beneath a functioning filtering bleb can be treated using radioactive plaque therapy. In this case, we were able to achieve both tumor regression and glaucoma control by covering the plaque with an amniotic membrane graft.

  20. Genetics Home Reference: Dandy-Walker malformation

    Science.gov (United States)

    ... Twitter Home Health Conditions Dandy-Walker malformation Dandy-Walker malformation Printable PDF Open All Close All Enable ... to view the expand/collapse boxes. Description Dandy-Walker malformation affects brain development, primarily development of the ...

  1. A rare case of anal carcinosarcoma with human papilloma virus infection in both biphasic tumor elements: An immunohistochemical, molecular and ultrastructural study.

    Science.gov (United States)

    Hickman, Richard A; Bradshaw, Azore-Dee; Cassai, Nicholas; Neto, Antonio Galvao; Zhou, David; Fu, Tinghao; Lee, Peng; Pei, Zhiheng; Wieczorek, Rosemary

    2016-12-01

    Carcinosarcoma of the anus is rare and has yet to be reportedly associated with the keratinocyte-specific Human Papilloma Virus (HPV). We describe a case of anal carcinosarcoma with HPV infection in both the epithelial and mesenchymal components of the tumor by immunohistochemistry, chromogenic in-situ hybridization (CISH) and further supported by electron microscopy (EM). Microscopic examination of the tumor showed nests of poorly-differentiated invasive squamous cell carcinoma with basaloid features intermixed with a hypercellular, atypical spindle cell proliferation. Immunohistochemistry demonstrated that the epithelial component was positive for AE1/AE3, p63, CK5/6 and p16, whilst the mesenchymal component was positive for smooth muscle actin, vimentin, and focally positive for desmin and p16, consistent with carcinosarcoma. The tumor was negative for GATA-3, CK7 and CK20. CISH demonstrated that the tumor was positive for high risk HPV (subtype 16/18) in both tumor components. EM further supported the presence of intracellular virus particles (~50 nm) that is compatible with HPV infection. Infection of both epithelial and mesenchymal tumor components by HPV has not been previously observed in the gastrointestinal tract. This finding may represent initial epithelial HPV infection with subsequent divergent tumoral differentiation and suggests the presence of viral replication in both biphasic tumor components.

  2. Sir Gilbert Thomas Walker

    Indian Academy of Sciences (India)

    He was educated at St Paul's School and later at the. Trinity College ... Walker spent the next 21 years doing research on monsoon ... J Bjerknes in 1969, 11 years after Walker's death. ... water-colours of landscapes at the Shimla Art Exhibition.

  3. Vicious walkers in a potential

    International Nuclear Information System (INIS)

    Bray, Alan J; Winkler, Karen

    2004-01-01

    We consider N vicious walkers moving in one dimension in a one-body potential v(x). Using the backward Fokker-Planck equation we derive exact results for the asymptotic form of the survival probability Q(x, t) of vicious walkers initially located at (x 1 , ..., x N ) = x, when v(x) is an arbitrary attractive potential. Explicit results are given for a square-well potential with absorbing or reflecting boundary conditions at the walls, and for a harmonic potential with an absorbing or reflecting boundary at the origin and the walkers starting on the positive half line. By mapping the problem of N vicious walkers in zero potential onto the harmonic potential problem, we rederive the results by Fisher (1984 J. Stat. Phys. 34 667) and Krattenthaler et al (2000 J. Phys. A: Math. Gen. 33 8835) respectively for vicious walkers on an infinite line and on a semi-infinite line with an absorbing wall at the origin. This mapping also gives a new result for vicious walkers on a semi-infinite line with a reflecting boundary at the origin: Q(x,t) ∼ t N(N-1)/2

  4. Three friendly walkers

    Science.gov (United States)

    Jensen, Iwan

    2017-01-01

    More than 15 years ago Guttmann and Vöge (2002 J. Stat. Plan. Inference 101 107), introduced a model of friendly walkers. Since then it has remained unsolved. In this paper we provide the exact solution to a closely allied model which essentially only differs in the boundary conditions. The exact solution is expressed in terms of the reciprocal of the generating function for vicious walkers which is a D-finite function. However, ratios of D-finite functions are inherently not D-finite and in this case we prove that the friendly walkers generating function is the solution to a non-linear differential equation with polynomial coefficients, it is in other words D-algebraic. We find using numerically exact calculations a conjectured expression for the generating function of the original model as a ratio of a D-finite function and the generating function for vicious walkers. We obtain an expression for this D-finite function in terms of a {{}2}{{F}1} hypergeometric function with a rational pullback and its first and second derivatives. Dedicated to Tony Guttmann on the occasion of his 70th birthday.

  5. Curvature properties of four-dimensional Walker metrics

    International Nuclear Information System (INIS)

    Chaichi, M; Garcia-Rio, E; Matsushita, Y

    2005-01-01

    A Walker n-manifold is a semi-Riemannian manifold, which admits a field of parallel null r-planes, r ≤ n/2. In the present paper we study curvature properties of a Walker 4-manifold (M, g) which admits a field of parallel null 2-planes. The metric g is necessarily of neutral signature (+ + - -). Such a Walker 4-manifold is the lowest dimensional example not of Lorentz type. There are three functions of coordinates which define a Walker metric. Some recent work shows that a Walker 4-manifold of restricted type whose metric is characterized by two functions exhibits a large variety of symplectic structures, Hermitian structures, Kaehler structures, etc. For such a restricted Walker 4-manifold, we shall study mainly curvature properties, e.g., conditions for a Walker metric to be Einstein, Osserman, or locally conformally flat, etc. One of our main results is the exact solutions to the Einstein equations for a restricted Walker 4-manifold

  6. Membrane Protein Mobility and Orientation Preserved in Supported Bilayers Created Directly from Cell Plasma Membrane Blebs.

    Science.gov (United States)

    Richards, Mark J; Hsia, Chih-Yun; Singh, Rohit R; Haider, Huma; Kumpf, Julia; Kawate, Toshimitsu; Daniel, Susan

    2016-03-29

    Membrane protein interactions with lipids are crucial for their native biological behavior, yet traditional characterization methods are often carried out on purified protein in the absence of lipids. We present a simple method to transfer membrane proteins expressed in mammalian cells to an assay-friendly, cushioned, supported lipid bilayer platform using cell blebs as an intermediate. Cell blebs, expressing either GPI-linked yellow fluorescent proteins or neon-green fused transmembrane P2X2 receptors, were induced to rupture on glass surfaces using PEGylated lipid vesicles, which resulted in planar supported membranes with over 50% mobility for multipass transmembrane proteins and over 90% for GPI-linked proteins. Fluorescent proteins were tracked, and their diffusion in supported bilayers characterized, using single molecule tracking and moment scaling spectrum (MSS) analysis. Diffusion was characterized for individual proteins as either free or confined, revealing details of the local lipid membrane heterogeneity surrounding the protein. A particularly useful result of our bilayer formation process is the protein orientation in the supported planar bilayer. For both the GPI-linked and transmembrane proteins used here, an enzymatic assay revealed that protein orientation in the planar bilayer results in the extracellular domains facing toward the bulk, and that the dominant mode of bleb rupture is via the "parachute" mechanism. Mobility, orientation, and preservation of the native lipid environment of the proteins using cell blebs offers advantages over proteoliposome reconstitution or disrupted cell membrane preparations, which necessarily result in significant scrambling of protein orientation and typically immobilized membrane proteins in SLBs. The bleb-based bilayer platform presented here is an important step toward integrating membrane proteomic studies on chip, especially for future studies aimed at understanding fundamental effects of lipid interactions

  7. Identical TP53 mutations in pelvic carcinosarcomas and associated serous tubal intraepithelial carcinomas provide evidence of their clonal relationship.

    Science.gov (United States)

    Ardighieri, Laura; Mori, Luigi; Conzadori, Sara; Bugatti, Mattia; Falchetti, Marcella; Donzelli, Carla Maria; Ravaggi, Antonella; Odicino, Franco E; Facchetti, Fabio

    2016-07-01

    Pelvic carcinosarcomas (PCSs) are rare aggressive biphasic tumors that localize in the ovary, fallopian tube, or peritoneum and present frequently as bilateral disease. We undertook a morphological, p53 immunohistochemical and TP53 gene mutational analysis study in a single institution cohort of 16 PCSs in order to investigate the nature of bilateral tumors and to shed light on their origin and pathogenesis. Of the 16 patients, 10 presented with bilateral disease, 6 with a carcinosarcoma in both adnexa, and the remaining cases with a carcinosarcoma in one adnexum and a carcinoma in the opposite. The carcinoma component showed high-grade serous features in 13/16 of cases (81 %). In 10 patients (63 %), a serous tubal intraepithelial carcinoma (STIC) was found, in one case bilateral, making a total of 11 STICs. STIC was found only in cases with a carcinoma component with high-grade serous features. All 10 bilateral tumors and all 11 PCS-associated STICs showed a similar p53 immunostaining pattern. At mutation analysis of the TP53 gene, all five bilateral PCS contained an identical mutation in both localizations. Furthermore, a TP53 mutation was found in 8 of 10 STICs, with an identical mutation in the associated PCS. The finding of similar p53 immunostaining in all bilateral cases and identical TP53 mutations in most PCS-associated STIC provides evidence for a clonal relation between these neoplastic lesions, supporting a metastatic nature of bilateral PCS and suggesting that they have an extraovarian origin in a STIC.

  8. The reasonable timing of the adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent: suggestion based on progression patterns

    International Nuclear Information System (INIS)

    Yu, Jeong Il; Choi, Doo Ho; Huh, Seung Jae; Park, Won; Oh, Dong Ryul; Bae, Duk Soo

    2013-01-01

    We designed this study to identify and suggest the reasonable timing of adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent and patterns of progression. We retrospectively analyzed a total of 50 carcinosarcoma patients diagnosed between 1995 and 2010. Among these 50 patients, 32 underwent curative surgery and 13 underwent maximal tumor debulking surgery. The remaining five patients underwent biopsy only. Twenty-six patients received chemotherapy, and 15 patients received adjuvant radiotherapy. The median follow-up period was 17.3 months. Curative resection (p < 0.001) and stage (p < 0.001) were statistically significant factors affecting survival. During follow-up, 30 patients showed progression. Among these, eight patients (16.0%) had loco-regional progression only. The patients who had received adjuvant radiotherapy did not show loco-regional progression, and radiotherapy was a significant negative risk factor for loco-regional progression (p = 0.01). The time to loco-regional progression was much earlier for non-curative than curative resection (range, 0.7 to 7.6 months vs. 7.5 to 39.0 months). Adjuvant radiotherapy in the treatment of carcinosarcoma might be related to a low loco-regional progression rate. Radiotherapy should be considered in non-curatively resected patients as soon as possible.

  9. Why is walker-assisted gait metabolically expensive?

    Science.gov (United States)

    Priebe, Jonathon R; Kram, Rodger

    2011-06-01

    Walker-assisted gait is reported to be ∼200% more metabolically expensive than normal bipedal walking. However, previous studies compared different walking speeds. Here, we compared the metabolic power consumption and basic stride temporal-spatial parameters for 10 young, healthy adults walking without assistance and using 2-wheeled (2W), 4-wheeled (4W) and 4-footed (4F) walker devices, all at the same speed, 0.30m/s. We also measured the metabolic power demand for walking without any assistive device using a step-to gait at 0.30m/s, walking normally at 1.25m/s, and for repeated lifting of the 4F walker mimicking the lifting pattern used during 4F walker-assisted gait. Similar to previous studies, we found that the cost per distance walked was 217% greater with a 4F walker at 0.30m/s compared to unassisted, bipedal walking at 1.25m/s. Compared at the same speed, 0.30m/s, using a 4F walker was still 82%, 74%, and 55% energetically more expensive than walking unassisted, with a 4W walker and a 2W walker respectively. The sum of the metabolic cost of step-to walking plus the cost of lifting itself was equivalent to the cost of walking with a 4F walker. Thus, we deduce that the high cost of 4F walker assisted gait is due to three factors: the slow walking speed, the step-to gait pattern and the repeated lifting of the walker. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. A walker with a device of partial suspension for patients with gait disturbance: body weight supported walker.

    Science.gov (United States)

    Ochi, Mitsuhiro; Makino, Kenichiro; Wada, Futoshi; Saeki, Satoru; Hachisuka, Kenji

    2009-09-01

    We developed a walker, the Body Weight Supported (BWS) Walker, with a device of partial suspension for patients with gait disturbance. It consists of a light frame with casters, a harness, and a winch system. One therapist alone can perform gait training safely with the BWS Walker without any additional physical load, even if a patient has severe gait disturbance, and the therapist can concentrate on evaluating and improving the patient' s standing balance and gait pattern. Because the BWS Walker is less expensive, simpler, and easier to operate than other BWS systems, we believe the BWS Walker can be widely applicable in training for patients with severe and moderate gait disturbance.

  11. Fibreglass Total Contact Casting, Removable Cast Walkers, and Irremovable Cast Walkers to Treat Diabetic Neuropathic Foot Ulcers: A Health Technology Assessment

    Science.gov (United States)

    Costa, Vania; Tu, Hong Anh; Wells, David; Weir, Mark; Holubowich, Corinne; Walter, Melissa

    2017-01-01

    Background Diabetic neuropathic foot ulcers are a risk factor for lower leg amputation. Many experts recommend offloading with fibreglass total contact casting, removable cast walkers, and irremovable cast walkers as a way to treat these ulcers. Methods We completed a health technology assessment, which included an evaluation of clinical benefits and harms, value for money, and patient preferences for offloading devices. We performed a systematic literature search on August 17, 2016, to identify randomized controlled trials that compared fibreglass total contact casting, removable cast walkers, and irremovable cast walkers with other treatments (offloading or non-offloading) in patients with diabetic neuropathic foot ulcers. We developed a decision-analytic model to assess the cost-effectiveness of fibreglass total contact casting, removable cast walkers, and irremovable cast walkers, and we conducted a 5-year budget impact analysis. Finally, we interviewed people with diabetes who had lived experience with foot ulcers, asking them about the different offloading devices and the factors that influenced their treatment choices. Results We identified 13 randomized controlled trials. The evidence suggests that total contact casting, removable cast walkers, and irremovable cast walkers are beneficial in the treatment of neuropathic, noninfected foot ulcers in patients with diabetes but without severe peripheral arterial disease. Compared to removable cast walkers, ulcer healing was improved with total contact casting (moderate quality evidence; risk difference 0.17 [95% confidence interval 0.00–0.33]) and irremovable cast walkers (low quality evidence; risk difference 0.21 [95% confidence interval 0.01–0.40]). We found no difference in ulcer healing between total contact casting and irremovable cast walkers (low quality evidence; risk difference 0.02 [95% confidence interval −0.11–0.14]). The economic analysis showed that total contact casting and irremovable

  12. Families of vicious walkers

    International Nuclear Information System (INIS)

    Cardy, John; Katori, Makoto

    2003-01-01

    We consider a generalization of the vicious walker problem in which N random walkers in R d are grouped into p families. Using field-theoretic renormalization group methods we calculate the asymptotic behaviour of the probability that no pairs of walkers from different families have met up to time t. For d > 2, this is constant, but for d -α , which we compute to O(ε 2 ) in an expansion in ε = 2 - d. The second-order term depends on the ratios of the diffusivities of the different families. In two dimensions, we find a logarithmic decay (ln t) -α-bar and compute α-bar exactly

  13. Recent progress on DNA based walkers.

    Science.gov (United States)

    Pan, Jing; Li, Feiran; Cha, Tae-Gon; Chen, Haorong; Choi, Jong Hyun

    2015-08-01

    DNA based synthetic molecular walkers are reminiscent of biological protein motors. They are powered by hybridization with fuel strands, environment induced conformational transitions, and covalent chemistry of oligonucleotides. Recent developments in experimental techniques enable direct observation of individual walkers with high temporal and spatial resolution. The functionalities of state-of-the-art DNA walker systems can thus be analyzed for various applications. Herein we review recent progress on DNA walker principles and characterization methods, and evaluate various aspects of their functions for future applications. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Baby walkers--health visitors' current practice, attitudes and knowledge.

    Science.gov (United States)

    Kendrick, Denise; Illingworth, Rachel; Hapgood, Rhydian; Woods, Amanda J; Collier, Jacqueline

    2003-09-01

    Baby walkers are a commonly used item of nursery equipment. Between 12% and 50% of parents whose infant uses a walker report that their child has suffered a walker-related injury. Health visitors' knowledge, attitudes and practice with regard to walkers and related health education has not been explored so far. The aim of the study was to describe health visitors' knowledge of walkers and walker-related injuries, their attitudes towards walkers and current practice with regard to walker health education, and to examine the relationship between knowledge and attitudes and knowledge and practice. A survey was carried out with 64 health visitors prior to participation in a randomized controlled trial assessing the effectiveness of an educational package in reducing baby walker use. The response rate was 95%. Half of the health visitors always discussed walkers postnatally, most frequently at the 6-9 month check. Most did not usually discuss the frequency of walker-related injuries. Most had negative attitudes towards walkers, but believed that parents hold positive attitudes to them and that it is hard to persuade parents not to use them. Health visitors had a limited knowledge of walker use and walker-related injuries. Those giving advice on walkers most often had higher knowledge scores than those giving advice less often (P = 0.03). Those with higher knowledge scores held more negative attitudes towards walkers (rs = 0.29, P = 0.023) and believed parents to have more positive attitudes towards walkers (rs = -0.49, P negotiating alternatives to their use. The provision of audio-visual aids for discussing walkers might also be helpful.

  15. 21 CFR 890.3825 - Mechanical walker.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Mechanical walker. 890.3825 Section 890.3825 Food... DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3825 Mechanical walker. (a) Identification. A mechanical walker is a four-legged device with a metal frame intended for medical purposes to...

  16. Sir Gilbert Thomas Walker

    Indian Academy of Sciences (India)

    playa fundamental role in the variability of the earth's climate. Walker noted a tendency of ... Walker was however not able to ascertain the physical mechanism governing these oscillations. In the first two ... In 1927, he made the follow- ing prophetic statement: "There is, to-day, always a risk that specialists in two subjects,.

  17. Aging in mortal superdiffusive Lévy walkers

    Science.gov (United States)

    Stage, Helena

    2017-12-01

    A growing body of literature examines the effects of superdiffusive subballistic movement premeasurement (aging or time lag) on observations arising from single-particle tracking. A neglected aspect is the finite lifetime of these Lévy walkers, be they proteins, cells, or larger structures. We examine the effects of aging on the motility of mortal walkers, and discuss the means by which permanent stopping of walkers may be categorized as arising from "natural" death or experimental artifacts such as low photostability or radiation damage. This is done by comparison of the walkers' mean squared displacement (MSD) with the front velocity of propagation of a group of walkers, which is found to be invariant under time lags. For any running time distribution of a mortal random walker, the MSD is tempered by the stopping rate θ . This provides a physical interpretation for truncated heavy-tailed diffusion processes and serves as a tool by which to better classify the underlying running time distributions of random walkers. Tempering of aged MSDs raises the issue of misinterpreting superdiffusive motion which appears Brownian or subdiffusive over certain time scales.

  18. Aging in mortal superdiffusive Lévy walkers.

    Science.gov (United States)

    Stage, Helena

    2017-12-01

    A growing body of literature examines the effects of superdiffusive subballistic movement premeasurement (aging or time lag) on observations arising from single-particle tracking. A neglected aspect is the finite lifetime of these Lévy walkers, be they proteins, cells, or larger structures. We examine the effects of aging on the motility of mortal walkers, and discuss the means by which permanent stopping of walkers may be categorized as arising from "natural" death or experimental artifacts such as low photostability or radiation damage. This is done by comparison of the walkers' mean squared displacement (MSD) with the front velocity of propagation of a group of walkers, which is found to be invariant under time lags. For any running time distribution of a mortal random walker, the MSD is tempered by the stopping rate θ. This provides a physical interpretation for truncated heavy-tailed diffusion processes and serves as a tool by which to better classify the underlying running time distributions of random walkers. Tempering of aged MSDs raises the issue of misinterpreting superdiffusive motion which appears Brownian or subdiffusive over certain time scales.

  19. Dandy-Walker variant in Coffin-Siris syndrome.

    Science.gov (United States)

    Imai, T; Hattori, H; Miyazaki, M; Higuchi, Y; Adachi, S; Nakahata, T

    2001-04-22

    We describe a five-month-old male infant with Coffin-Siris syndrome, the so-called Dandy-Walker variant (hypoplasia of the cerebellar vermis with cystic dilatation of the fourth ventricle, but without enlargement of the posterior fossa), and partial agenesis of the corpus callosum. Dandy-Walker malformation and mega cisterna magna, but not Dandy-Walker variant, have been reported in Coffin-Siris syndrome. The presence of Dandy-Walker variant in the infant we described confirms that the full continuum of the Dandy-Walker complex can occur in Coffin-Siris syndrome. The yet unidentified gene(s) for the syndrome may be related to the development of the hindbrain. Copyright 2001 Wiley-Liss, Inc.

  20. Fall prevention walker during rehabilitation

    Science.gov (United States)

    Tee, Kian Sek; E, Chun Zhi; Saim, Hashim; Zakaria, Wan Nurshazwani Wan; Khialdin, Safinaz Binti Mohd; Isa, Hazlita; Awad, M. I.; Soon, Chin Fhong

    2017-09-01

    This paper proposes on the design of a walker for the prevention of falling among elderlies or patients during rehabilitation whenever they use a walker to assist them. Fall happens due to impaired balance or gait problem. The assistive device is designed by applying stability concept and an accelerometric fall detection system is included. The accelerometric fall detection system acts as an alerting device that acquires body accelerometric data and detect fall. Recorded accelerometric data could be useful for further assessment. Structural strength of the walker was verified via iterations of simulation using finite element analysis, before being fabricated. Experiments were conducted to identify the fall patterns using accelerometric data. The design process and detection of fall pattern demonstrates the design of a walker that could support the user without fail and alerts the helper, thus salvaging the users from injuries due to fall and unattended situation.

  1. Vicious walkers and hook Young tableaux

    International Nuclear Information System (INIS)

    Hikami, Kazuhiro; Imamura, Takashi

    2003-01-01

    We consider a generalization of the vicious walker model. Using a bijection map between the path configuration of the non-intersecting random walkers and the hook Young diagram, we compute the probability concerning the number of movements of the walker. Applying the saddle point method, we reveal that the scaling limit gives the Tracy-Widom distribution, which is the same with the limit distribution of the largest eigenvalues of the Gaussian unitary ensemble

  2. Trabeculectomy bleb needling and antimetabolite administration practices in the UK: a glaucoma specialist national survey.

    Science.gov (United States)

    Mercieca, Karl; Drury, Brett; Bhargava, Archana; Fenerty, Cecilia

    2017-12-06

    To evaluate, describe and quantify the diversity in postoperative antimetabolite administration and bleb needling practices among glaucoma specialists performing trabeculectomy surgery within the UK and Ireland. A cross-sectional online survey was distributed to all consultant glaucoma specialists who are on the United Kingdom and Eire Glaucoma Society (UKEGS) contact list. Participants were asked specific questions about their current practices for post-trabeculectomy antimetabolite administration followed by questions directly related to bleb needling procedures. 60 (83%) of UKEGS glaucoma subspecialty consultants completed the survey. 70% of respondents administered 5-fluorouracil (5-FU) in their clinic room while 30% used a separate treatment room. Doses of 5-FU varied considerably but 70% used 5 mg as standard. Techniques used to reduce corneal toxicity included precipitation with amethocaine (44%) or benoxinate (14%), saline wash (14%) and modified injection technique (8%). Topical antibiotics and/or betadine were used to prevent infection following 5-FU injection in just over 50%. Bleb needling was exclusively performed in operating theatre by 56% of respondents and solely at the slit lamp in the clinic room by 12%. A further 30% used a combination of both theatre and outpatient clinic rooms. Anti-metabolites used were 5-FU (72%) and mitomycin C (22%) with 12% using either of the two substances. There is a significantly wide variety of current practices for antimetabolite administration and bleb needling within the UK and Ireland. This may be influenced by a glaucoma surgeon's specific experience and audit results as well as particular clinical set-up, availability of antimetabolite and clinic room space. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Quincke random walkers

    Science.gov (United States)

    Pradillo, Gerardo; Heintz, Aneesh; Vlahovska, Petia

    2017-11-01

    The spontaneous rotation of a sphere in an applied uniform DC electric field (Quincke effect) has been utilized to engineer self-propelled particles: if the sphere is initially resting on a surface, it rolls. The Quincke rollers have been widely used as a model system to study collective behavior in ``active'' suspensions. If the applied field is DC, an isolated Quincke roller follows a straight line trajectory. In this talk, we discuss the design of a Quincke roller that executes a random-walk-like behavior. We utilize AC field - upon reversal of the field direction a fluctuation in the axis of rotation (which is degenerate in the plane perpendicular to the field and parallel to the surface) introduces randomness in the direction of motion. The MSD of an isolated Quincke walker depends on frequency, amplitude, and waveform of the electric field. Experiment and theory are compared. We also investigate the collective behavior of Quincke walkers,the transport of inert particles in a bath of Quincke walkers, and the spontaneous motion of a drop containing Quincke active particle. supported by NSF Grant CBET 1437545.

  4. Topical Mitomycin-C versus Subconjunctival 5‑Fluorouracil for Management of Bleb Failure

    Directory of Open Access Journals (Sweden)

    Mohammad Pakravan

    2011-01-01

    Full Text Available Purpose: To compare the efficacy and safety of topical mitomycin‑C (MMC drops with that of subconjunctival 5‑fluorouracil (5‑FU injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation (PT+PCIOL. Methods: In a randomized comparative study, 37 eyes of 37 patients with impending early bleb failure received MMC 0.02% eye drops for 2 or 4 weeks (19 eyes or subconjunctival 5‑FU injections, 5 mg per dose (18 eyes. Complete success was defined as 5 < IOP ≤ 18 mmHg without medications. Results: Baseline characteristics were comparable between the study groups. However, there were more cases of combined PT+PCIOL in the MMC group [11 (57.9% eyes versus 3 (16.7% eyes, P = 0.017]. Mean preoperative IOP was 20.5΁8.85 mmHg in the MMC group and 25.82΁11.35 mmHg in the 5‑FU group (P = 0.129, which was decreased to 13.2΁6.1 and 10.6΁4.8 mmHg respectively after 12 months (P = 0.159. There was no significant difference between the study groups in terms of bleb extent (P = 0.170, height (P = 0.178 or vascularity (P = 0.366. At the end of the study, complete success was achieved in 13 eyes (68.4% in the MMC group and 14 eyes (77.8% in the 5‑FU group (P = 0.714. The survival of success at 8 months (median follow-up was 89.5% and 86.5% in the MMC and 5‑FU groups respectively; the number of glaucoma medications (P = 0.707 and best-corrected visual acuity (P = 0.550 were also comparable. Complication rates were similar in the study groups (P = 0.140. Conclusion: Topical MMC 0.02% has comparable safety and efficacy to subconjunctival 5‑FU injections for management of early bleb failure. Topical MMC 0.02% drops are more convenient and can be initiated first, while 5‑FU injections may be reserved for eyes with an insufficient response to topical MMC.

  5. 75 FR 38833 - Walker River Basin Acquisition Program

    Science.gov (United States)

    2010-07-06

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Walker River Basin Acquisition Program AGENCY... (Reclamation) is canceling work on the Environmental Impact Statement (EIS) for the Walker River Basin... Walker River, primarily for irrigated agriculture, have resulted in a steadily declining surface...

  6. Modulation of the toxicity and antitumour activity of alkylating drugs by steroids.

    OpenAIRE

    Shepherd, R.; Harrap, K. R.

    1982-01-01

    The steroids prednisolone and progesterone significantly altered the therapeutic indices of the alkylating agents, nitrogen mustard, melphalan, cyclophosphamide, phenyl acetic mustard and chlorambucil. For nitrogen mustard, chlorambucil and phenyl acetic mustard, prednisolone reduced host toxicity in the rat and enhanced the antitumour effectiveness against alkylating-agent-resistant strains of the Yoshida sarcoma and Walker carcinosarcoma. Progesterone also increased the therapeutic index of...

  7. A review of the functionalities of smart walkers.

    Science.gov (United States)

    Martins, Maria; Santos, Cristina; Frizera, Anselmo; Ceres, Ramón

    2015-10-01

    There is a need to conceptualize and improve the investigation and developments in assistive devices, focusing on the design and effectiveness of walkers in the user's rehabilitation process and functional compensation. This review surveys the importance of smart walkers in maintaining mobility and discusses their potential in rehabilitation and their demands as assistive devices. It also presents related research in addressing and quantifying the smart walker's efficiency and influence on gait. Besides, it discusses smart walkers focusing on studies related to the concept of autonomous and shared-control and manual guidance, the use of smart walkers as personal helpers to sit-to-stand and diagnostic tools for patients' rehabilitation through the evaluation of their gait. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

  8. Random walk on a population of random walkers

    International Nuclear Information System (INIS)

    Agliari, E; Burioni, R; Cassi, D; Neri, F M

    2008-01-01

    We consider a population of N labelled random walkers moving on a substrate, and an excitation jumping among the walkers upon contact. The label X(t) of the walker carrying the excitation at time t can be viewed as a stochastic process, where the transition probabilities are a stochastic process themselves. Upon mapping onto two simpler processes, the quantities characterizing X(t) can be calculated in the limit of long times and low walkers density. The results are compared with numerical simulations. Several different topologies for the substrate underlying diffusion are considered

  9. Pediatricians' attitude about the use of infant walkers.

    Science.gov (United States)

    Kara, Semra; Yilmaz, Ayşe Esra; Gümüş Dogan, Derya; Bilici, Meki; Turkay, Sadi; Akca, Halise; Catal, Ferhat

    2013-12-01

    Infant walkers are still very popular even though their use might cause injuries. A survey was carried out to obtain information about attitudes and pediatricians' approach regarding the use of infant walkers. Two hundred and forty seven pediatricians who attended the 44th Turkish Congress of Pediatrics and Europediatrics (2008) were invited to reply to a questionnaire prepared by the authors. Two hundred and twenty six questionnaires replied in full were included. The median age of participants (119 women) was 39 years old (range: 29-58 years old). Out of the total, 4% recommended the use of a walker; 32.2% left the decision to parents' judgment, and 63.7% did not recommend its use. A hundred and five had previously treated an infant who had an injury associated to the use of the walker; out of them, 73.3% did not recommend its use and 57.1% stated that there should be a ban on the sale and manufacture of walkers. Out of the total number of surveyed pediatricians, 4% recommend the use of infant walkers and over 30% leave this decision to parents. Those pediatricians who took care of babies who had an injury associated to the use of a walker were less prone to recommending it.

  10. Using walker during walking: a pilot study for health elder.

    Science.gov (United States)

    Po-Chan, Yeh; Cherng-Yee, Leung

    2012-01-01

    Walker operation completely relies on the walker handle, however most marketed walkers possess two horizontal handles. Several researchers have suggested that horizontal handles might lead to wrist injury. Therefore, the purpose of this study is to assess the relevant design aspects of walker for elderly people. 28 elders participated in this study; when the experiment was started, subject walked on the tile for 3 meter distance twice by using walker. Data for analysis were selected at the corresponding wrist deviation and vertical force. The results showed that during walker using, the mean wrist deviation was greater than zero. The largest vertical force is significantly larger than the smallest one, and different wrist deviation occurred at three phases, the largest wrist deviation while raising walker is larger than the smallest one, however, no significant different was found between the largest and smallest wrist deviation while pressing walker. No significant correlation occurred between weight and wrist deviation. The correlation between weight and vertical force was significantly positive. With wrist deviation walker use may cause injury to upper-limb, however wrists remain in a neutral position during hand movement to prevent damage. The findings of this study should improve the design of walker handles to reduce the wrist deviations of users.

  11. Realization of Robertson-Walker spacetimes as affine hypersurfaces

    International Nuclear Information System (INIS)

    Chen Bangyen

    2007-01-01

    Due to the growing interest in embeddings of spacetimes in higher dimensional spaces, we consider a special type of embedding. We prove that Robertson-Walker spacetimes can be embedded as centroaffine hypersurfaces and graph hypersurfaces in some affine spaces in such a way that the induced relative metrics are exactly the Lorentzian metrics on the Robertson-Walker spacetimes. Such realizations allow us to view Robertson-Walker spacetimes and their submanifolds as affine submanifolds in a natural way. Consequently, our realizations make it possible to apply the tools of affine differential geometry to study Robertson-Walker spacetimes and their submanifolds

  12. Variante de Dandy Walker: relato de caso = Dandy Walker variant: a case report

    Directory of Open Access Journals (Sweden)

    Khan, Richard Lester

    2009-01-01

    Conclusões: este artigo procura caracterizar a variante de Dandy Walker, que é uma malformação congênita do sistema nervoso central e é o tipo mais comum da Síndrome de Dandy Walker. Seu fenótipo é variável, devendo-se sempre pesquisar malformações tanto intra quanto extracranianas, visto que o risco de mortalidade pós-natal aumenta quando existe esta associação. O tratamento envolve equipe multidisciplinar e o prognóstico é reservado, variando conforme o fenótipo

  13. Biomimetic Molecular Signaling using DNA Walkers on Microparticles.

    Science.gov (United States)

    Damase, Tulsi Ram; Spencer, Adam; Samuel, Bamidele; Allen, Peter B

    2017-06-22

    We report the release of catalytic DNA walkers from hydrogel microparticles and the detection of those walkers by substrate-coated microparticles. This might be considered a synthetic biology analog of molecular signal release and reception. One type of particles was coated with components of a DNA one-step strand displacement (OSD) reaction to release the walker. A second type of particle was coated with substrate (or "track") for the molecular walker. We distinguish these particle types using fluorescence barcoding: we synthesized and distinguished multiple particle types with multicolor fluorescence microscopy and automated image analysis software. This represents a step toward amplified, multiplex, and microscopically localized detection based on DNA nanotechnology.

  14. Dandy-Walker Syndrome

    Science.gov (United States)

    ... treatment options. Other research indicates that mothers with diabetes and those with rubella (German measles) during pregnancy are more likely to have a child with Dandy-Walker syndrome. × What research is being ...

  15. Dandy Walker malformation

    African Journals Online (AJOL)

    PROF. EZECHUKWU

    2014-10-01

    - tion of Dandy walker syndrome to enhance early diagnosis, prompt intervention and better outcome ... tion of the central nervous system. It results from a .... Other predisposing factors include first trimester exposure to rubella ...

  16. Beliefs about the use of baby walkers.

    Science.gov (United States)

    Chagas, Paula S C; Mancini, Marisa C; Tirado, Marcella G A; Megale, Luiz; Sampaio, Rosana F

    2011-01-01

    To understand the opinion of the parents about the baby walker and compare the age of gait acquisition between infants that used a walker and those that did not. In this quali-quantitative study, an interview involving a semi-structured questionnaire was carried out with 26 parents, 14 of whose infants used the equipment (BWG) and 12 of whose infants did not (NBWG) prior to gait acquisition. After extensive content analysis, categories for interpreting the results emerged. For data triangulation, the age of gait acquisition was documented by weekly telephone contact. Student's t-test was used for comparison between groups with a significance level of α=0.05. The following categories were identified in the parents' reports: a) information about the baby walker; b) doubt/decision to use it vs. certainty about not using it; c) beliefs about the use of a baby-walker; and d) benefits and harm from use. The age of independent gait acquisition did not differ between groups (p=0.837): BWG initiated gait at 376.17 (SD=32.62) days and NBWG did so at 378.75 (SD=27.99) days. The beliefs and feelings that permeate the decision to use a baby walker illustrate the different rationales adopted by parents about the role of this equipment in the child's development of gait and autonomy. The use of a baby walker did not influence the age of gait acquisition. The results broaden the understanding of choices that influence child-rearing practices prior to gait acquisition.

  17. Singular perturbations of empty Robertson-Walker cosmologies

    International Nuclear Information System (INIS)

    Newman, R.P.A.C.

    1979-02-01

    An investigation is presented which concerns a class of cosmological models defined by McVittie (1931): the universe is envisaged as a set of galaxies, idealised as point particles, which provide singular perturbations of Robertson-Walker cosmologies. The perturbations are considered only to first order in the gravitational coupling constant (8πG)/c 2 . Attention will only be given to such perturbations of empty Robertson-Walker cosmologies. Chapter 1 summarises the observational support for the type of model employed and for the smallness of the quantities to be used as perturbation coefficients. Chapter 2 provides the prerequisite analysis of Robertson-Walker cosmologies. Perturbations of empty Robertson-Walker cosmologies of non-vanishing cosmical constant are considered in general in Chapter 3. The structure of McVittie's singularly perturbed Robertson-Walker cosmologies are considered in detail in Chapter 4. The remaining chapters seek to investigate them further by way of their optical properties. Chapter 5 provides the necessary theory of geometric optics with particular regard to the intensity and distortion of a beam of light, and Chapter 6 applies this theory to the McVittie cosmologies. Chapter 7 sees the definition of an averaging procedure which leads to expressions for the intensity and distortion of a typical beam of light from a point source. (author)

  18. The role of walkers' needs and expectations in supporting maintenance of attendance at walking groups: a longitudinal multi-perspective study of walkers and walk group leaders.

    Science.gov (United States)

    Kassavou, Aikaterini; Turner, Andrew; French, David P

    2015-01-01

    There is good evidence that when people's needs and expectations regarding behaviour change are met, they are satisfied with that change, and maintain those changes. Despite this, there is a dearth of research on needs and expectations of walkers when initially attending walking groups and whether and how these needs and expectations have been satisfied after a period of attendance. Equally, there is an absence of research on how people who lead these groups understand walkers' needs and walk leaders' actions to address them. The present study was aimed at addressing both of these gaps in the research. Two preliminary thematic analyses were conducted on face-to-face interviews with (a) eight walkers when they joined walking groups, five of whom were interviewed three months later, and (b) eight walk leaders. A multi-perspective analysis building upon these preliminary analyses identified similarities and differences within the themes that emerged from the interviews with walkers and walk leaders. Walkers indicated that their main needs and expectations when joining walking groups were achieving long-term social and health benefits. At the follow up interviews, walkers indicated that satisfaction with meeting similar others within the groups was the main reason for continued attendance. Their main source of dissatisfaction was not feeling integrated in the existing walking groups. Walk leaders often acknowledged the same reasons for walkers joining and maintaining attendance at walking. However, they tended to attribute dissatisfaction and drop out to uncontrollable environmental factors and/or walkers' personalities. Walk leaders reported a lack of efficacy to effectively address walkers' needs. Interventions to increase retention of walkers should train walk leaders with the skills to help them modify the underlying psychological factors affecting walkers' maintenance at walking groups. This should result in greater retention of walkers in walking groups, thereby

  19. The role of walkers' needs and expectations in supporting maintenance of attendance at walking groups: a longitudinal multi-perspective study of walkers and walk group leaders.

    Directory of Open Access Journals (Sweden)

    Aikaterini Kassavou

    Full Text Available There is good evidence that when people's needs and expectations regarding behaviour change are met, they are satisfied with that change, and maintain those changes. Despite this, there is a dearth of research on needs and expectations of walkers when initially attending walking groups and whether and how these needs and expectations have been satisfied after a period of attendance. Equally, there is an absence of research on how people who lead these groups understand walkers' needs and walk leaders' actions to address them. The present study was aimed at addressing both of these gaps in the research.Two preliminary thematic analyses were conducted on face-to-face interviews with (a eight walkers when they joined walking groups, five of whom were interviewed three months later, and (b eight walk leaders. A multi-perspective analysis building upon these preliminary analyses identified similarities and differences within the themes that emerged from the interviews with walkers and walk leaders.Walkers indicated that their main needs and expectations when joining walking groups were achieving long-term social and health benefits. At the follow up interviews, walkers indicated that satisfaction with meeting similar others within the groups was the main reason for continued attendance. Their main source of dissatisfaction was not feeling integrated in the existing walking groups. Walk leaders often acknowledged the same reasons for walkers joining and maintaining attendance at walking. However, they tended to attribute dissatisfaction and drop out to uncontrollable environmental factors and/or walkers' personalities. Walk leaders reported a lack of efficacy to effectively address walkers' needs.Interventions to increase retention of walkers should train walk leaders with the skills to help them modify the underlying psychological factors affecting walkers' maintenance at walking groups. This should result in greater retention of walkers in walking

  20. Ressecção de bolsa hiperfuncionante para tratamento de hipotonia ocular crônica: relato de casos Resection of overfiltration bleb for the treatment of chronic ocular hypotony: case reports

    Directory of Open Access Journals (Sweden)

    Sebastião Cronemberger

    2004-08-01

    Full Text Available Relatar os resultados obtidos com a ressecção de bolsa hiperfuncionante pós-trabeculectomia (TREC com mitomicina C (MMC para o tratamento da hipotonia ocular crônica. Cinco pacientes portadores de hipotonia ocular crônica causada por hiperfunção de bolsa fistulante pós- trabeculectomia com mitomicina foram tratados pela ressecção da bolsa. O diagnóstico de hiperfunção da bolsa foi feito com base em critérios estabelecidos pelos autores. A hipotonia ocular foi revertida nos cinco pacientes, sem medicação num seguimento mínimo de cinco e máximo de 26 meses (média de 14,0 ± 7,9 meses. A ressecção da bolsa foi procedimento eficaz para reverter a hipotonia ocular crônica causada pela hiperfunção da mesma pós-trabeculectomia com mitomicina.To present the results of bleb resection for the treatment of overfiltering bleb after trabeculectomy with mitomycin C (MMC associated with chronic ocular hypotony. Five patients with chronic ocular hypotony caused by overfiltering bleb underwent bleb resection. The authors established the criteria for the diagnosis of overfiltering bleb. Ocular hypotony was reversed in all patients without medication. The mean follow-up was 14.0 ± 7.9 months. Bleb resection is a good approach for the treatment of chronic ocular hypotony secondary to overfiltering bleb.

  1. Intelligent control of a smart walker and its performance evaluation.

    Science.gov (United States)

    Grondin, Simon L; Li, Qingguo

    2013-06-01

    Recent technological advances have allowed the development of force-dependent, intelligently controlled smart walkers that are able to provide users with enhanced mobility, support and gait assistance. The purpose of this study was to develop an intelligent rule-based controller for a smart walker to achieve a smooth interaction between the user and the walker. This study developed a rule-based mapping between the interaction force, measured by a load cell attached to the walker handle, and the acceleration of the walker. Ten young, healthy subjects were used to evaluate the performance of the proposed controller compared to a well-known admittance-based control system. There were no significant differences between the two control systems concerning their user experience, velocity profiles or average cost of transportation. However, the admittance-based control system required a 1.2N lower average interaction force to maintain the 1m/s target speed (p = 0.002). Metabolic data also indicated that smart walker-assisted gait could considerably reduce the metabolic demand of walking with a four-legged walker.

  2. A pilot study on slit lamp-adapted optical coherence tomography imaging of trabeculectomy filtering blebs.

    NARCIS (Netherlands)

    Theelen, T.; Wesseling, P.; Keunen, J.E.E.; Klevering, B.J.

    2007-01-01

    BACKGROUND: Our study aims to identify anatomical characteristics of glaucoma filtering blebs by means of slit lamp-adapted optical coherence tomography (SL-OCT) and to identify new parameters for the functional prognosis of the filter in the early post-operative period. METHODS: Patients with

  3. Hydrogel Walkers with Electro-Driven Motility for Cargo Transport.

    Science.gov (United States)

    Yang, Chao; Wang, Wei; Yao, Chen; Xie, Rui; Ju, Xiao-Jie; Liu, Zhuang; Chu, Liang-Yin

    2015-08-28

    In this study, soft hydrogel walkers with electro-driven motility for cargo transport have been developed via a facile mould-assisted strategy. The hydrogel walkers consisting of polyanionic poly(2-acrylamido-2-methylpropanesulfonic acid-co-acrylamide) exhibit an arc looper-like shape with two "legs" for walking. The hydrogel walkers can reversibly bend and stretch via repeated "on/off" electro-triggers in electrolyte solution. Based on such bending/stretching behaviors, the hydrogel walkers can move their two "legs" to achieve one-directional walking motion on a rough surface via repeated "on/off" electro-triggering cycles. Moreover, the hydrogel walkers loaded with very heavy cargo also exhibit excellent walking motion for cargo transport. Such hydrogel systems create new opportunities for developing electro-controlled soft systems with simple design/fabrication strategies in the soft robotic field for remote manipulation and transportation.

  4. Perceiving Direction of a Walker: Effect of Body Appearance

    Directory of Open Access Journals (Sweden)

    Kazuya Ono

    2011-05-01

    Full Text Available Human can perceive others' walking direction accurately even with 117ms observation (Sato, et al., ECVP2008. We aimed to see whether appearance of walker's body affects the accuracy of perceiving direction of the walker. Thus, we employed three different appearances: realistic human computer-graphics body (CG-human, nonrealistic cylinder-assembled body (Cylinders, and point-light walker (Points. We made a three-dimensional model of an adult-size walker who walked at a place. CG-human stimuli were generated by rendering the model with smooth shading. We made Cylinders stimuli by replacing body parts such as arms, legs, head, and hands with cylinders. Points stimuli were made by tracking 18 positions (mostly joints of the body like biological motion. One of walkers was presented for 117, 250, 500 or 1000ms while its direction was randomly varied by 3deg steps to 21deg left or right. Observers judged whether the walker was walking toward them (hit or not (miss, and self-range was measured in terms of the standard deviation for hit distributions. The perceived self-range was narrowed with long duration, and with CG-human stimulus. It is suggested that the accuracy of perceiving walker's direction depends on body appearance, and it is higher for human-like body than nonhuman body.

  5. A new species of Ormocerus Walker (Hymenoptera: Pteromalidae) from North America and a range expansion for Ormocerus latus Walker

    Science.gov (United States)

    Ormocerus dirigoius, n. sp. is described and compared to the North American O. americanus Dzhanokmen and Grissell and European species O. latus Walker and O. vernalis Walker. A range expansion into the Nearctic is reported for O. latus, previously only known from the Palearctic. Specimens were colle...

  6. Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease

    Directory of Open Access Journals (Sweden)

    Sagara H

    2012-08-01

    Full Text Available Hideto Sagara,1,2 Tomohiro Iida,2,3 Kimimori Saito,4 Hiroki Noji,2 Masashi Ogasawara,2 Hiroshi Oyamada21The Marui Eye Clinic, Fukushima, 2Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 3Tokyo Women's Medical University, Tokyo, 4Matuki Eye Clinic, Fukushima, JapanBackground: Sodium hyaluronate and autologous serum eye drops are used to treat ocular surface disease (OSD and are reported to prevent and treat late-onset bleb leaks following trabeculectomy with mitomycin C. In this study, we evaluated the efficacy of a combination of sodium hyaluronate and autologous serum eye drops and treatment for obstructive meibomian gland dysfunction as a therapy for late-onset bleb leaks after trabeculectomy with mitomycin C.Methods: This was a retrospective, interventional, nonsimultaneous study of 12 subjects (12 eyes of mean age of 64.3 ± 18.3 years with OSD and apparent late-onset bleb leaks following trabeculectomy with mitomycin C between 1998 and 2008. We compared patients diagnosed with leakages before July 2005, who had been treated with separate eye drop solutions containing 0.1% sodium hyaluronate, 50% autologous serum, and 0.3% ofloxacin (sodium hyaluronate and autologous serum group, n = 7, with patients diagnosed from August 2005 to December 2008, who were treated with a combination of eye drops (0.1% sodium hyaluronate, 50% autologous serum, and 0.08% levofloxacin hydrate and eyelid massage and warm compresses for obstructive meibomian gland dysfunction (combination eye drop group, n = 5.Results: Leakage was resolved in one patient (14.3% in the separately treated sodium hyaluronate and autologous serum eye drop group and in five patients (100% in the combination eye drop group (P = 0.015. The period after resolution of leakage with conservative treatment was 23 months in the one eye in the sodium hyaluronate and autologous serum group and 36–61 (mean 52.4 ± 10.1 months in the five eyes in the

  7. 78 FR 48301 - Establishment of Class E Airspace; Walker, MN

    Science.gov (United States)

    2013-08-08

    ...-0266; Airspace Docket No. 13-AGL-11] Establishment of Class E Airspace; Walker, MN AGENCY: Federal... at Walker, MN. Controlled airspace is necessary to accommodate new Area Navigation (RNAV) Standard Instrument Approach Procedures at Walker Municipal Airport. The FAA is taking this action to enhance the...

  8. A walker used as a lifting device.

    Science.gov (United States)

    Glimskär, Bo; Hjalmarson, Jenny; Lundberg, Stefan; Larsson, Tore

    2014-05-01

    To develop assistive technology that would help an older person to arise from a kneeling position to a standing one. Developing a prototype, based on an inclusive design and then testing the prototype to verify the approach. The prototype was subsequently tested by a panel of 20 elderly users. These tests were observed and filmed. Participants' experiences of being lifted with the elevation seat were registered with the VIDAR ergonomic assessment system. None of the 20 participants used a walker at that time. In response to a question of whether, assuming they might have to use a walker in the future, they thought that a walker with an elevating seat would be helpful, 18 said that it would. Two of the participants did not believe that they would ever have to use a walker. A simple assistive technology such as a walker equipped with an elevating seat would in many of these cases simplify matters and reduce the distress of people who fall often. In addition, such a device can allow people who fall often to live in their homes longer. For caregivers dealing frequently with people who fall, this assistive device can contribute to decreasing occupational injuries. Development of a lifting device that can help people raise themselves up entirely on their own, or with minimal assistance, would be a revolutionary step for the individual. Lifting devices in use today requires much more extensive assistance from home helpers or others and due to the risk of injuries it is a great value for the helpers that easy to use devices develops. A walker equipped with an elevating seat could even provide a potential for people to stay in their homes longer.

  9. Dandy-Walker syndrome together with occipital encephalocele.

    Science.gov (United States)

    Cakmak, A; Zeyrek, D; Cekin, A; Karazeybek, H

    2008-08-01

    Dandy-Walker malformation is an anomaly characterized by dysgenesis of the foramina of Magendie and Lushka in the upper 4(th) ventricle, hypoplasia of the cerebellar vermis and agenesis of the corpus callosum. Encephalocele is diagnosed from the calvarium defect, cerebrospinal fluid (CSF) and herniation of the meninges. It is the rarest neural tube defect. A 7 x 9 cm encephalocele was found on physical examination of a 6-day old baby boy patient. From cranial magnetic resonance, it was seen that the posterior fossa was enlarged with cysts and there was agenesis of the vermis. A connection was established between the ventricle and the development of cysts on the posterior fossa. These findings were evaluated as significant from the aspect of Dandy-Walker malformation. The extension of the bone defect in the left occipital area towards the posterior, and the cranio-caudal diameter reaching 9 cm was seen to be in accordance with encephalocele. It is rare for Dandy-Walker syndrome to occur together with occipital encephalocele. The authors present a case of Dandy-Walker syndrome together with occipital encephalocele.

  10. Bleb Point: Mimicker of Pneumothorax in Bullous Lung Disease

    Directory of Open Access Journals (Sweden)

    Gelabert, Christopher

    2015-05-01

    Full Text Available In patients presenting with severe dyspnea, several diagnostic challenges arise in distinguishing the diagnosis of pneumothorax versus several other pulmonary etiologies like bullous lung disease, pneumonia, interstitial lung disease, and acute respiratory distress syndrome. Distinguishing between large pulmonary bullae and pneumothorax is of the utmost importance, as the acute management is very different. While multiple imaging modalities are available, plain radiographs may be inadequate to make the diagnosis and other advanced imaging may be difficult to obtain. Ultrasound has a very high specificity for pneumothorax. We present a case where a large pulmonary bleb mimics the lung point and therefore inaccurately suggests pneumothorax. [West J Emerg Med. 2015;16(3:447–449.

  11. Patterns of care, predictors and outcomes of chemotherapy for uterine carcinosarcoma: a National Cancer Database analysis.

    Science.gov (United States)

    Rauh-Hain, J Alejandro; Starbuck, Kristen D; Meyer, Larissa A; Clemmer, Joel; Schorge, John O; Lu, Karen H; Del Carmen, Marcela G

    2015-10-01

    Evaluate rates of chemotherapy and radiotherapy delivery in the treatment of uterine carcinosarcoma, and compare clinical outcomes of treated and untreated patients. The National Cancer Database was queried to identify patients diagnosed with uterine carcinosarcoma between 2003 and 2011. The impact of chemotherapy on survival was analyzed using the Kaplan-Meier method. Factors predictive of outcome were compared using the Cox proportional hazards model. A total of 10,609 patients met study eligibility criteria. Stages I, II, III, and IV disease accounted for 2997 (28.2%), 642 (6.1%), 2037 (19.2%), and 1316 (12.4%) of the study population, respectively. Most patients (91.0%) underwent definitive surgery, and lymphadenectomy was performed in 68.7% of the patients. Chemotherapy was administered in 2378 (22.4%) patients, radiotherapy to 2196 (20.7%), adjuvant chemo-radiation to 1804 (17.0%), and 4231 (39.9%) of women did not received adjuvant therapy. Utilization of chemotherapy became more frequent over time. Over the entire study period, after adjusting for race, period of diagnosis, facility location, facility type, insurance provider, stage, age, treatment modality, lymph node dissection, socioeconomic status, and comorbidity index, there was an association between treatment modality and survival. The lowest hazard ratio observed was in patients that received chemo-radiation. The strongest quantitative predictor of death was stage at the time of diagnosis. In addition, surgical treatment, lymph node dissection, most recent time-periods, lower comorbidity index, and higher socioeconomic status were associated with improved survival. The overall rates of chemotherapy use have increased over time. Adjuvant chemotherapy and chemo-radiation were associated with improved survival. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Madame Kara Walker, notre artiste

    Directory of Open Access Journals (Sweden)

    Riché Deianne Richardson

    2008-01-01

    Full Text Available « Mon Ennemi, Mon Frère, Mon Bourreau, Mon Amour, » the epic exhibition at ARC/ Musée d’art moderne de la ville de Paris running from 20 June to 9 September, reveals the creative genius and vision of the artist Kara Walker, who was born in Stockton, California in 1969. The show is her most comprehensive one yet in Europe and includes the form that Walker has uniquely developed and for which she is best known, cut-out black silhouettes that are sometimes small and at other times gigantic and r...

  13. Giant Pendulous Carcinosarcoma – Squamous Cell Carcinoma-Type - of the Leg – A Case Report and Review of the Literature

    OpenAIRE

    Wollina, Uwe; Riedel, Ina; Abushika, Mohammad R.; Lotti, Torello; Tchernev, Georgi

    2018-01-01

    Cutaneous carcinosarcoma (CCS) is a rare non-melanoma skin cancer with a biphasic growth pattern. A tumour is composed of epithelial and mesenchymal cells that show clonality. In most cases, CCS develops in the head-and-neck region on the chronic sun-exposed skin of males. Here, we describe an 80-year-old female patient who developed a giant, pendulous CCS on the leg.  A tumour was surgically removed. We found no evidence of metastatic spread.

  14. Multiple Walkers in the Wang-Landau Algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Brown, G

    2005-12-28

    The mean cost for converging an estimated density of states using the Wang-Landau algorithm is measured for the Ising and Heisenberg models. The cost increases in a power-law fashion with the number of spins, with an exponent near 3 for one-dimensional models, and closer to 2.4 for two-dimensional models. The effect of multiple, simultaneous walkers on the cost is also measured. For the one-dimensional Ising model the cost can increase with the number of walkers for large systems. For both the Ising and Heisenberg models in two-dimensions, no adverse impact on the cost is observed. Thus multiple walkers is a strategy that should scale well in a parallel computing environment for many models of magnetic materials.

  15. Dandy-Walker Malformation

    African Journals Online (AJOL)

    rme

    Dandy-Walker malformation is a rare congenital malformation and involves the cerebellum and fourth ventricle. The condition is characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilatation of the fourth ventricle, and enlargement of the posterior fossa. A large number of concomitant problems may be ...

  16. Obituary: Robert Mowbray Walker, 1929-2004

    Science.gov (United States)

    Schoenherr, Neil T.

    2004-12-01

    Robert M. Walker, PhD, Professor of Physics in Arts & Sciences and a faculty fellow of the McDonnell Center for the Space Sciences, died of stomach cancer Thursday, 12 February 2004, in Brussels, Belgium. He was 75. Walker worked on the frontiers of space research for more than four decades. Robert Walker was born in Philadelphia on 6 February 1929. His mother was Dorothy Potter and he considered Roger Potter his father though he was not his biological father. His early years were spent in New York City and in upstate New York. He attended the Bronx High School of Science, earned his BS in physics from Union College and in 1954, he received his PhD in particle physics from Yale University. He subsequently joined the General Electric Laboratory in Schenectady, New York where he studied the radiation effects in solids. His work on defects in irradiated copper is still regarded as the definitive work on the topic. In the early 1960s, Walker's discovery of fossil nuclear particle tracks in minerals was instrumental to new developments in geo-chronology and cosmic ray physics. In particular, his discovery of tracks from nuclei heavier than iron opened a new frontier of cosmic ray physics. He subsequently pioneered the use of plastics to detect and count such nuclei in cosmic ray balloon flights. Beginning in 1966, when he moved to Washington University and became the first McDonnell Professor of Physics, his research interests turned more toward space physics. He was the inaugural director of the McDonnell Center, which was established in 1975 by a gift from aerospace pioneer James S. McDonnell. Walker was a member of the NASA committee that allocated samples of the first returned lunar materials, and his laboratory led the way in deciphering their record of lunar, solar system and galactic evolution. Together with Ghislaine Crozaz and other colleagues, Walker made path breaking laboratory studies of the first moon rocks revealing the history of solar radiation and

  17. Interacting walkers on the Cayley tree, and polymer statistics

    International Nuclear Information System (INIS)

    Priezzhev, V.B.

    1986-01-01

    We obtain the generating function for an ensemble of random walkers on the Cayley tree of coordination number z. The pair interaction between walkers is taken into account. This forbids two walkers to occupy the same lattice point after an equal number of steps. Interacting polymer statistics results from this model if one associates time (or the number of steps) with an additional space coordinate. The limiting free energy appears in a form that corresponds to the phase transition of ''3/2 order.''

  18. Designing instrumented walker to measure upper-extremity's efforts: A case study.

    Science.gov (United States)

    Khodadadi, Mohammad; Baniasad, Mina Arab; Arazpour, Mokhtar; Farahmand, Farzam; Zohoor, Hassan

    2018-02-26

    The high prevalence of shoulder pain in using walkers in patients who have spinal cord injury (SCI). Also, the limited options available to economically measure grip forces in walkers, which drove the need to create one. This article describes a method to obtain upper-extremities' forces and moments in a person with SCI by designing an appropriate instrumented walker. First, since the commercial multidirectional loadcells are too expensive, custom loadcells are fabricated. Ultimately, a complete gait analysis by means of VICON motion analysis and using inverse dynamic method has been held to measure upper-extremities' efforts. The results for a person with SCI using a two-wheel walker in low and high heights and a basic walker show that there are higher shoulder and elbow flexion-extension moments and also higher shoulder forces in superior-inferior direction and higher elbow and wrist forces in anterior-posterior directions. The results are not much different in using two different types of walker. By using the proposed method, upper-extremities' forces and moments were obtained and the results were compared to each other in using two different walkers.

  19. 78 FR 25234 - Proposed Establishment of Class E Airspace; Walker, MN

    Science.gov (United States)

    2013-04-30

    ...-0266; Airspace Docket No. 13-AGL-11] Proposed Establishment of Class E Airspace; Walker, MN AGENCY... action proposes to establish Class E airspace at Walker, MN. Controlled airspace is necessary to accommodate new Standard Instrument Approach Procedures (SIAP) at Walker Municipal Airport. The FAA is taking...

  20. Giant Pendulous Carcinosarcoma – Squamous Cell Carcinoma-Type - of the Leg – A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Uwe Wollina

    2018-01-01

    Full Text Available Cutaneous carcinosarcoma (CCS is a rare non-melanoma skin cancer with a biphasic growth pattern. A tumour is composed of epithelial and mesenchymal cells that show clonality. In most cases, CCS develops in the head-and-neck region on the chronic sun-exposed skin of males. Here, we describe an 80-year-old female patient who developed a giant, pendulous CCS on the leg.  A tumour was surgically removed. We found no evidence of metastatic spread.

  1. Human-robot interaction strategies for walker-assisted locomotion

    CERN Document Server

    Cifuentes, Carlos A

    2016-01-01

    This book presents the development of a new multimodal human-robot interface for testing and validating control strategies applied to robotic walkers for assisting human mobility and gait rehabilitation. The aim is to achieve a closer interaction between the robotic device and the individual, empowering the rehabilitation potential of such devices in clinical applications. A new multimodal human-robot interface for testing and validating control strategies applied to robotic walkers for assisting human mobility and gait rehabilitation is presented. Trends and opportunities for future advances in the field of assistive locomotion via the development of hybrid solutions based on the combination of smart walkers and biomechatronic exoskeletons are also discussed. .

  2. Target Therapies for Uterine Carcinosarcomas: Current Evidence and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Salvatore Giovanni Vitale

    2017-05-01

    Full Text Available Carcinosarcomas (CS in gynecology are very infrequent and represent only 2–5% of uterine cancers. Despite surgical cytoreduction and subsequent chemotherapy being the primary treatment for uterine CS, the overall five-year survival rate is 30 ± 9% and recurrence is extremely common (50–80%. Due to the poor prognosis of CS, new strategies have been developed in the last few decades, targeting known dysfunctional molecular pathways for immunotherapy. In this paper, we aimed to gather the available evidence on the latest therapies for the treatment of CS. We performed a systematic review using the terms “uterine carcinosarcoma”, “uterine Malignant Mixed Müllerian Tumors”, “target therapies”, “angiogenesis therapy”, “cancer stem cell therapy”, “prognostic biomarker”, and “novel antibody-drug”. Based on our results, the differential expression and accessibility of epithelial cell adhesion molecule-1 on metastatic/chemotherapy-resistant CS cells in comparison to normal tissues and Human Epidermal Growth Factor Receptor 2 (HER2 open up new possibilities in the field of target therapy. Nevertheless, future investigations are needed to clarify the impact of these new therapies on survival rate and medium-/long-term outcomes.

  3. Evaluation of the purified fraction of Wilbrandia (c. f. verticillata for antitumour activity

    Directory of Open Access Journals (Sweden)

    V. S. N. Rao

    1991-01-01

    Full Text Available Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2 have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%.

  4. Anthropometric characteristics of top-class Olympic race walkers.

    Science.gov (United States)

    Gomez-Ezeiza, Josu; Tam, Nicholas; Torres-Unda, Jon; Granados, Cristina; Santos-Concejero, Jordan

    2018-04-20

    Typical training programmes in elite race walkers involve high training volumes at low and moderate intensities, which have been reported to induce functional and structural adaptations at an anthropometric level. Since anthropometrical variables are closely related to movement efficiency and performance in endurance events, the aim of this study was to describe the anthropometric profile of world-class race walkers. Twenty-nine world-class race walkers (21 men & 8 women) participated in this study. Anthropometric characteristics, including height, body mass, eight skinfolds, five girths and four bone breadths were measured. Body composition, somatotype, somatotype dispersion mean, somatotype attitudinal mean and height to weight ratio, as well as skinfolds extremity to trunk ratio were also calculated. Mean height, body mass and body mass index were 177.1 ± 7.1 cm, 66.4 ± 5.8 kg, and21.2±1.3kg·m2 formenand165.6±4.5cm,53.6±3.7kg,and19.6±1.6kg·m2for women, respectively. Women presented greater body fat content (6.7 ± 0.6 vs. 12.2 ± 0.8%; very large effect), less muscle mass (65.6 ± 4.6 vs. 61.6 ± 2.6 kg; large effect), and were more endomorphic (large effect) than men. Men specialists in 20-km showed greater muscle mass (66.7 ± 4.9 vs. 64.4 ± 4.3 kg; moderate effect), and slightly higher skinfolds, girths, body fat content and were more mesomorphic than 50-km specialists (moderate effect). The present study expands the limited knowledge on the anthropometric characteristics and somatotype elements of elite top-class race walkers. The characterisation of the morphology of elite race walkers provides coaches a reference values to control the training development of the race walker, as well as providing reference values to improve talent identification.

  5. Four-wheeled walker related injuries in older adults in the Netherlands.

    Science.gov (United States)

    van Riel, K M M; Hartholt, K A; Panneman, M J M; Patka, P; van Beeck, E F; van der Cammen, T J M

    2014-02-01

    With ageing populations worldwide, mobility devices are used more than ever. In the current literature there is no consensus whether the available mobility devices safely improve the mobility of their users. Also, evidence is lacking concerning the risks and types of injuries sustained while using a four-wheeled walker. To assess injury risks and injury patterns in older adults (≥65 years) who presented at Emergency Departments (ED) in the Netherlands with an injury due to using a four-wheeled walker. In this study, the Dutch Injury Surveillance System was used to obtain a national representative sample of annual ED visits in the Netherlands in the adult population (≥65 years) sustaining an injury while using a four-wheeled walker. The numbers of four-wheeled walker users in the Netherlands were obtained from the national insurance board. The numbers of ED visits were divided by the numbers of four-wheeled walker users to calculate age- and sex-specific injury risks. Annually 1869 older adults visited an ED after sustaining an injury while using a four-wheeled walker. Falls were the main cause of injury (96%). The injury risk was 3.1 per 100 users of four-wheeled walkers. Women (3.5 per 100 users) had a higher risk than men (2.0 per 100 users). Injury risk was the highest in women aged 85 years and older (6.2 per 100 users). The majority of injuries were fractures (60%) with hip fracture (25%) being the most common injury. Nearly half of all four-wheeled walker related injuries required hospitalisation, mostly due to hip fractures. Healthcare costs per injury were approximately €12 000. This study presents evidence that older adults experiencing a fall while using a four-wheeled walker are at high risk to suffer severe injuries.

  6. 21 CFR 890.3790 - Cane, crutch, and walker tips and pads.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cane, crutch, and walker tips and pads. 890.3790 Section 890.3790 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., crutch, and walker tips and pads. (a) Identification. Cane, crutch, and walker tips and pads are rubber...

  7. Severe Blue Rubber Bleb Nevus Syndrome in a Neonate

    DEFF Research Database (Denmark)

    Hansen, L; Wewer, V; Pedersen, S

    2008-01-01

    We report on a child with blue rubber bleb nevus syndrome (BRBNS) presenting during the first days of life with severe bleeding from the upper gastrointestinal tract. Medical treatment with methylprednisolone, cyklokapron, interferon 1 alpha and numerous blood transfusions were given to control...... problems. The case is unique because 1) it is the first neonatal case with BRBNS and severe gastrointestinal bleeding; 2) the patient was successfully treated by endoscopic electrocoagulation; and 3) the long-term follow-up. The use of electrocoagulation appears to have been effective and ablation...... bleeding during the first 3 years of life. Afterwards repeated endoscopic electrocoagulations were performed over a period of one year resulting in a termination of bleeding episodes. At ten years of age the patient developed spastic diplegia with slight walking disabilities, coordination and fine motor...

  8. Interaction of two walkers: wave-mediated energy and force.

    Science.gov (United States)

    Borghesi, Christian; Moukhtar, Julien; Labousse, Matthieu; Eddi, Antonin; Fort, Emmanuel; Couder, Yves

    2014-12-01

    A bouncing droplet, self-propelled by its interaction with the waves it generates, forms a classical wave-particle association called a "walker." Previous works have demonstrated that the dynamics of a single walker is driven by its global surface wave field that retains information on its past trajectory. Here we investigate the energy stored in this wave field for two coupled walkers and how it conveys an interaction between them. For this purpose, we characterize experimentally the "promenade modes" where two walkers are bound and propagate together. Their possible binding distances take discrete values, and the velocity of the pair depends on their mutual binding. The mean parallel motion can be either rectilinear or oscillating. The experimental results are recovered analytically with a simple theoretical framework. A relation between the kinetic energy of the droplets and the total energy of the standing waves is established.

  9. Effects of walker gender and observer gender on biological motion walking direction discrimination.

    Science.gov (United States)

    Yang, Xiaoying; Cai, Peng; Jiang, Yi

    2014-09-01

    The ability to recognize the movements of other biological entities, such as whether a person is walking toward you, is essential for survival and social interaction. Previous studies have shown that the visual system is particularly sensitive to approaching biological motion. In this study, we examined whether the gender of walkers and observers influenced the walking direction discrimination of approaching point-light walkers in fine granularity. The observers were presented a walker who walked in different directions and were asked to quickly judge the walking direction (left or right). The results showed that the observers demonstrated worse direction discrimination when the walker was depicted as male than when the walker was depicted as female, probably because the observers tended to perceive the male walkers as walking straight ahead. Intriguingly, male observers performed better than female observers at judging the walking directions of female walkers but not those of male walkers, a result indicating perceptual advantage with evolutionary significance. These findings provide strong evidence that the gender of walkers and observers modulates biological motion perception and that an adaptive perceptual mechanism exists in the visual system to facilitate the survival of social organisms. © 2014 The Institute of Psychology, Chinese Academy of Sciences and Wiley Publishing Asia Pty Ltd.

  10. Beliefs about the use of baby walkers

    OpenAIRE

    Chagas,Paula S. C.; Mancini,Marisa C.; Tirado,Marcella G. A.; Megale,Luiz; Sampaio,Rosana F.

    2011-01-01

    OBJECTIVES: To understand the opinion of the parents about the baby walker and compare the age of gait acquisition between infants that used a walker and those that did not. METHODS: In this quali-quantitative study, an interview involving a semi-structured questionnaire was carried out with 26 parents, 14 of whose infants used the equipment (BWG) and 12 of whose infants did not (NBWG) prior to gait acquisition. After extensive content analysis, categories for interpreting the results emerged...

  11. Mechanical efficiency of a champion walker | Wyndham | South ...

    African Journals Online (AJOL)

    Oxygen consumptions were measured on a champion walker, while walking at between 6·4 and 16·9 km / hand while running at between 11.3 and 17.7 km/h. Above 9.7 km /h the curve of oxygen consumption against speed for walking was almost twice as steep as that for running, indicating that even champion walkers are ...

  12. [Active and safe with wheeled walkers : Pilot study on feasibility of mobility exercises for wheeled walker users].

    Science.gov (United States)

    Pflaum, Marina; Lang, Frieder R; Freiberger, Ellen

    2016-07-01

    The number of older people with mobility impairments using wheeled walkers is increasing; however, the handling of these walking aids is often ineffective. Moreover, age-associated functional loss, environmental demands and fear of falling may additionally challenge mobility. The new training program "Active and safe with wheeled walkers" aims to enhance skills and to improve mobility. The present pilot study was carried out to assess the feasibility of the training as well as to identify training effects and methodological insights for further research. The study was carried out with 28 wheeled walker users (age 68-91 years) in assisted living facilities using a pre-post design. Of the participants 13 persons were trained for 10 weeks (90 min, twice a week) and 15 persons served as a control group. Data were collected on functional mobility, hand strength, leg strength, balance, walker handling and fear of falling. The drop-out rate for the training was 38 % due to health concerns (n = 2), lack of time (n = 1) and changes in health status independent of training (n = 3). Medium to large effects were detected. Data regarding the recruitment strategy and the acceptance of individual exercises are available. The results indicate a good feasibility and effectiveness of the training. The simple accessibility of the training was conducive for the regular participation. The everyday relevance of the results and the lack of comparable interventions suggest that further research efforts be carried out. Recruitment strategies, training requirements and data collection methods need to be optimized.

  13. A stochastic DNA walker that traverses a microparticle surface

    Science.gov (United States)

    Jung, C.; Allen, P. B.; Ellington, A. D.

    2016-02-01

    Molecular machines have previously been designed that are propelled by DNAzymes, protein enzymes and strand displacement. These engineered machines typically move along precisely defined one- and two-dimensional tracks. Here, we report a DNA walker that uses hybridization to drive walking on DNA-coated microparticle surfaces. Through purely DNA:DNA hybridization reactions, the nanoscale movements of the walker can lead to the generation of a single-stranded product and the subsequent immobilization of fluorescent labels on the microparticle surface. This suggests that the system could be of use in analytical and diagnostic applications, similar to how strand exchange reactions in solution have been used for transducing and quantifying signals from isothermal molecular amplification assays. The walking behaviour is robust and the walker can take more than 30 continuous steps. The traversal of an unprogrammed, inhomogeneous surface is also due entirely to autonomous decisions made by the walker, behaviour analogous to amorphous chemical reaction network computations, which have been shown to lead to pattern formation.

  14. Spacetime emergence of the robertson-walker universe from a matrix model.

    Science.gov (United States)

    Erdmenger, Johanna; Meyer, René; Park, Jeong-Hyuck

    2007-06-29

    Using a novel, string theory-inspired formalism based on a Hamiltonian constraint, we obtain a conformal mechanical system for the spatially flat four-dimensional Robertson-Walker Universe. Depending on parameter choices, this system describes either a relativistic particle in the Robertson-Walker background or metric fluctuations of the Robertson-Walker geometry. Moreover, we derive a tree-level M theory matrix model in this time-dependent background. Imposing the Hamiltonian constraint forces the spacetime geometry to be fuzzy near the big bang, while the classical Robertson-Walker geometry emerges as the Universe expands. From our approach, we also derive the temperature of the Universe interpolating between the radiation and matter dominated eras.

  15. Effects of aging on identifying emotions conveyed by point-light walkers.

    Science.gov (United States)

    Spencer, Justine M Y; Sekuler, Allison B; Bennett, Patrick J; Giese, Martin A; Pilz, Karin S

    2016-02-01

    The visual system is able to recognize human motion simply from point lights attached to the major joints of an actor. Moreover, it has been shown that younger adults are able to recognize emotions from such dynamic point-light displays. Previous research has suggested that the ability to perceive emotional stimuli changes with age. For example, it has been shown that older adults are impaired in recognizing emotional expressions from static faces. In addition, it has been shown that older adults have difficulties perceiving visual motion, which might be helpful to recognize emotions from point-light displays. In the current study, 4 experiments were completed in which older and younger adults were asked to identify 3 emotions (happy, sad, and angry) displayed by 4 types of point-light walkers: upright and inverted normal walkers, which contained both local motion and global form information; upright scrambled walkers, which contained only local motion information; and upright random-position walkers, which contained only global form information. Overall, emotion discrimination accuracy was lower in older participants compared with younger participants, specifically when identifying sad and angry point-light walkers. In addition, observers in both age groups were able to recognize emotions from all types of point-light walkers, suggesting that both older and younger adults are able to recognize emotions from point-light walkers on the basis of local motion or global form. (c) 2016 APA, all rights reserved).

  16. Development of the SORRI-BAURU Posterior Walker.

    Science.gov (United States)

    Nicholl, Anthony R J; Busnardo, Renato G; da Silva, Luciana M; Rodrigues, Ana Cláudia T; Luz, Fernanda R C; Bentim, Claudia C G; Medola, Fausto O; Paschoarelli, Luis C

    2015-01-01

    This study aimed to report on the design and development of a low cost Reverse Walker through a participative development cycle with people undergoing rehabilitation. The creation and fundamentals of the concept are described, as well as the development of prototypes and their provision to subjects with mobility problems. The Reverse Walker benefits the user by promoting a more upright posture and favoring the development of postural balance. Enhancing the mobility of people with disabilities may benefit their independence, social participation and quality of life.

  17. Two Cases of Carcinosarcomas of the Ovary Involved in Hereditary Cancer Syndromes.

    Science.gov (United States)

    Carnevali, Ileana W; Cimetti, Laura; Sahnane, Nora; Libera, Laura; Cavallero, Alessandra; Formenti, Giorgio; Riva, Cristina; Tibiletti, Maria Grazia

    2017-01-01

    Ovarian carcinosarcomas (OCS), also known as malignant mixed mesodermal/Müllerian tumors, are rare neoplasms (1%-4% of all malignant ovarian tumors) composed of high-grade malignant epithelial and mesenchymal elements. OCS occurs in older women. It is associated with a poor outcome and is usually not involved in inherited cancer syndromes. We present 2 cases of OCS; one arising in a patient with a pathogenetic BRCA1 mutation and the other in a woman affected by Lynch Syndrome (LS) carrying a MSH6 germline mutation. To the best of our knowledge, this is the first time that this second type of case has been reported. In this study, we investigated somatic impairment of the wild-type BRCA1 and MSH6 alleles in the OCS of these 2 patients. We also explored in both OCS, the occurrence of TP53 loss of function, which is a genetic alteration known to occur in BRCA-linked ovarian tumorigenesis but not in LS tumors. Moreover, we also provide further data about the histogenesis of OCS.

  18. Influence of temperature on current-induced domain wall motion and its Walker breakdown

    International Nuclear Information System (INIS)

    Fan, Lvchao; Hu, Jingguo; Su, Yuanchang; Zhu, Jinrong

    2016-01-01

    The current-driven domain wall propagation along a thin ferromagnetic strip with thermal field is studied by means of micromagnetic simulations. The results show that the velocity of domain wall is almost independent of temperature until Walker breakdown happened. However the thermal field can suppress Walker breakdown and makes domain wall move faster. Further analysis indicates that the thermal field tends to keep the out-of-plane magnetic moment of the domain wall stay in high value, which can promote domain wall motion and suppress the Walker breakdown by breaking the period of domain wall transformation. - Highlights: • Influences of temperature on the displacement and the velocity of DW are shown. • The suppression of Walker breakdown by temperature is given. • The reason for suppressing Walker breakdown is analyzed. • The breaking transformation period of Walker breakdown by temperature is given.

  19. Dynamics of unvisited sites in the presence of mutually repulsive random walkers

    International Nuclear Information System (INIS)

    Das, Pratap Kumar; Dasgupta, Subinay; Sen, Parongama

    2007-01-01

    We have considered the persistence of unvisited sites of a lattice, i.e., the probability S(t) that a site remains unvisited till time t in the presence of mutually repulsive random walkers in one dimension. The dynamics of this system has direct correspondence to that of the domain walls in a certain system of Ising spins where the number of domain walls becomes fixed following a zero-temperature quench. Here we get the result that S(t) ∼ exp(-αt β ) where β is close to 0.5 and α a function of the density of the walkers ρ. The fraction of persistent sites in the presence of independent walkers of density ρ' is known to be S'(t) = exp(-2√(2/π ρ't 1/2 ). We show that a mapping of the interacting walkers' problem to the independent walkers' problem is possible with ρ' = ρ/(1 - ρ) provided ρ' and ρ are small. We also discuss some other intricate results obtained in the interacting walkers' case

  20. Can use of walkers or canes impede lateral compensatory stepping movements?

    Science.gov (United States)

    Bateni, Hamid; Heung, Evelyn; Zettel, John; McLlroy, William E; Maki, Brian E

    2004-08-01

    Although assistive devices, such as walkers and canes are often prescribed to aid in balance control, recent studies have suggested that such devices may actually increase risk of falling. In this study, we investigated one possible mechanism: the potential for walkers or canes to interfere with, or constrain, lateral movement of the feet and thereby impede execution of compensatory stepping reactions during lateral loss of balance. Lateral stepping reactions were evoked, in 10 healthy young adults (ages 22-27 years), by means of sudden unpredictable medio-lateral support surface translation. Subjects were tested while holding and loading a standard pickup walker or single-tip cane or while using no assistive device (hands free or holding an object). Results supported the hypothesis that using a walker or cane can interfere with compensatory stepping. Collisions between the swing-foot and mobility aid were remarkably frequent when using the walker (60% of stepping reactions) and also occurred in cane trials (11% of stepping reactions). Furthermore, such collisions were associated with a significant reduction (26-37%) in lateral step length. It appeared that subjects were sometimes able to avoid collision by increasing the forward or backward displacement of the swing-foot or by moving the cane; however, attempts to lift the walker out of the way occurred rarely and were usually impeded due to collision between the contralateral walker post and stance foot. The fact that compensatory stepping behavior was altered significantly in such a healthy cohort clearly demonstrates some of the safety limitations inherent to these assistive devices, as currently designed. Copyright 2003 Elsevier B.V.

  1. Robertson-Walker solutions for various types of energy-momentum tensor

    International Nuclear Information System (INIS)

    Lukacs, B.

    1976-01-01

    Robertson-Walker solutions are important in general relativity as universe solutions. This paper contains a number of Robertson-Walker-type solutions for certain cases, namely, for noncharged massless scalar meson fields, viscous fluids, Hookean elastic mediums, and Kelvin-Voigt viscoelastic systems. (author)

  2. Experimental detection of domain wall propagation above the Walker field

    International Nuclear Information System (INIS)

    Kondou, Kouta; Chiba, Daichi; Kobayashi, Kensuke; Ono, Teruo; Ohshima, Norikazu; Kasai, Shinya

    2012-01-01

    The domain wall (DW) velocity above the Walker field drops abruptly with increasing magnetic field, because of the so-called Walker breakdown, where the DW moves with a precessional mode. On applying the higher field, the DW velocity again starts to increase gradually. We report the DW propagation around this local minimum regime in detail, investigated through the time-resolved electrical detection technique, with a magnetic tunnel junction. Just above the Walker field, we succeeded in detecting the precessional motion of the DW in a real-time regime, while a different mode appeared around the local minimum of the DW velocity. (paper)

  3. Maximum distance between the Leader and the Laggard for three Brownian walkers

    International Nuclear Information System (INIS)

    Majumdar, Satya N; Bray, Alan J

    2010-01-01

    We consider three independent Brownian walkers moving on a line. The process terminates when the leftmost walker (the 'Leader') meets either of the other two walkers. For arbitrary values of the diffusion constants D 1 (the Leader), D 2 and D 3 of the three walkers, we compute the probability distribution P(m|y 2 , y 3 ) of the maximum distance m between the Leader and the current rightmost particle (the 'Laggard') during the process, where y 2 and y 3 are the initial distances between the Leader and the other two walkers. The result has, for large m, the form P(m|y 2 , y 3 ) ∼ A(y 2 , y 3 )m −δ , where δ = (2π − θ)/(π − θ) and θ= cos -1 (D 1 /√((D 1 +D 2 )(D 1 +D 3 ))). The amplitude A(y 2 , y 3 ) is also determined exactly

  4. Generalized Friedmann-Robertson-Walker metric and redundancy in the generalized Einstein equations

    International Nuclear Information System (INIS)

    Kao, W.F.; Pen, U.

    1991-01-01

    A nontrivial redundancy relation, due to the differential structure of the gravitational Bianchi identity as well as the symmetry of the Friedmann-Robertson-Walker metric, in the gravitational field equation is clarified. A generalized Friedmann-Robertson-Walker metric is introduced in order to properly define a one-dimensional reduced problem which offers an alternative approach to obtain the gravitational field equations on Friedmann-Robertson-Walker spaces

  5. Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin

    DEFF Research Database (Denmark)

    Larsen, Anna Karina; Lametsch, Rene; Elce, John S.

    2008-01-01

    Dynamic regulation of the actin cytoskeleton is important for cell motility, spreading and the formation of membrane surface extensions such as lamellipodia, ruffles and blebs. The ubiquitous calpains contribute to integrin-mediated cytoskeletal remodelling during cell migration and spreading, by...

  6. Twentieth century Walker Circulation change: data analysis and model experiments

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Qingjia [Leibniz-Institut fuer Meereswissenschaften, Kiel (Germany); Chinese Research Academy of Environmental Sciences, River and Coastal Environment Research Center, Beijing (China); Chinese Academy of Sciences, Key Laboratory of Ocean Circulation and Waves, Institute of Oceanology, Qingdao (China); Latif, Mojib; Park, Wonsun; Keenlyside, Noel S.; Martin, Thomas [Leibniz-Institut fuer Meereswissenschaften, Kiel (Germany); Semenov, Vladimir A. [Leibniz-Institut fuer Meereswissenschaften, Kiel (Germany); A.M. Obukhov Institute of Atmospheric Physics, Russian Academy of Sciences, Moscow (Russian Federation)

    2012-05-15

    Recent studies indicate a weakening of the Walker Circulation during the twentieth century. Here, we present evidence from an atmospheric general circulation model (AGCM) forced by the history of observed sea surface temperature (SST) that the Walker Circulation may have intensified rather than weakened. Observed Equatorial Indo-Pacific Sector SST since 1870 exhibited a zonally asymmetric evolution: While the eastern part of the Equatorial Pacific showed only a weak warming, or even cooling in one SST dataset, the western part and the Equatorial Indian Ocean exhibited a rather strong warming. This has resulted in an increase of the SST gradient between the Maritime Continent and the eastern part of the Equatorial Pacific, one driving force of the Walker Circulation. The ensemble experiments with the AGCM, with and without time-varying external forcing, suggest that the enhancement of the SST gradient drove an anomalous atmospheric circulation, with an enhancement of both Walker and Hadley Circulation. Anomalously strong precipitation is simulated over the Indian Ocean and anomalously weak precipitation over the western Pacific, with corresponding changes in the surface wind pattern. Some sensitivity to the forcing SST, however, is noticed. The analysis of twentieth century integrations with global climate models driven with observed radiative forcing obtained from the Coupled Model Intercomparison Project (CMIP) database support the link between the SST gradient and Walker Circulation strength. Furthermore, control integrations with the CMIP models indicate the existence of strong internal variability on centennial timescales. The results suggest that a radiatively forced signal in the Walker Circulation during the twentieth century may have been too weak to be detectable. (orig.)

  7. Revalidation of Ceresa terminalis walker and its placement in Stictocephala Stål (Hemiptera, Membracidae Revalidação de Ceresa terminalis walker e sua alocação em Stictocephala Stål (Hemiptera, Membracidae

    Directory of Open Access Journals (Sweden)

    Gabriel S. de Andrade

    2005-12-01

    Full Text Available Ceresa terminalis Walker, 1851 is reinstated and transferred to Stictocephala Stål, 1869: Stictocephala terminalis (Walker, 1851 sp. rev., comb. nov.Ceresa terminalis Walker, 1851 é revalidada e transferida para Stictocephala Stål, 1869: Stictocephala terminalis (Walker, 1851 sp. rev., comb. nov.

  8. Integral constraints on perturbations of Robertson-Walker cosmologies

    International Nuclear Information System (INIS)

    Ellis, G.F.R.; Jaklitsch, M.J.

    1989-01-01

    Integral constraints occur in the case of spherically symmetric inhomogeneities in Robertson-Walker universes, and (according to Traschen) in the case of general perturbations of these models. It is shown that these constraints are the same in the case of spherical symmetry, and they are interpreted as 'fitting conditions', that is, as constraints on the background Robertson-Walker model rather than on the nature of inhomogeneities. These integral constraints significantly affect the interpretation of anisotropies in the cosmic microwave background radiation. 22 refs

  9. Design and Control of JAIST Active Robotic Walker

    OpenAIRE

    Lee, Geunho; Ohnuma, Takanori; Chong, Nak Young

    2010-01-01

    This paper presents the design and control of a novel assistive robotic walker that we call “JAIST activerobotic walker (JARoW)”. JARoW is developed to providepotential users with sufficient ambulatory capability in anefficient、 cost-effective way. Specifically、 our focus is placed on how to allow easier maneuverability by creating a natural interface between the user and JARoW. For the purpose、 we develop a rotating infrared sensor to detect the user’s lower limb movement. The implementation...

  10. A new walker with upper trunk suspension system for severely disabled patients.

    Science.gov (United States)

    Scoppetta, C; Scoppetta, M

    2013-10-01

    We have recently designed a new type of walker for those severely disabled patients who cannot walk with commonly used medical walkers. A drawing and the description of this new walker is reported in order to permit the worldwide companies as well as artisans to develop and produce it for the people affected from severe motor problems. This walker supposes the patient wearing either a modified climbing harness or equipped clothes and being suspended to the walking frame. It consists in two series of bands suspending the patient from the frame; the upper one suspends him for the upper part of his trunk, the lower one by his pelvis. This walker is suggested for patients belonging to three principal groups: (1) Persons who have no trunk control (e.g.: patients affected by severe stroke or ataxias). (2) Persons whose walk is allowed only if they achieve a significant reduction (up to 30-40%) of the their body weight charging on trunk, spine, and lower limbs. (3) Persons who need a differentiated reduction of the body weight either among anterior and posterior side or among their right and left part of the body (hemiparesis, Parkinson disease, scoliosis, kyphosis). Creating this walker is easy; producing costs are low; there are no maintenance costs.

  11. Ordering statistics of four random walkers on a line

    Science.gov (United States)

    Helenbrook, Brian; ben-Avraham, Daniel

    2018-05-01

    We study the ordering statistics of four random walkers on the line, obtaining a much improved estimate for the long-time decay exponent of the probability that a particle leads to time t , Plead(t ) ˜t-0.91287850 , and that a particle lags to time t (never assumes the lead), Plag(t ) ˜t-0.30763604 . Exponents of several other ordering statistics for N =4 walkers are obtained to eight-digit accuracy as well. The subtle correlations between n walkers that lag jointly, out of a field of N , are discussed: for N =3 there are no correlations and Plead(t ) ˜Plag(t) 2 . In contrast, our results rule out the possibility that Plead(t ) ˜Plag(t) 3 for N =4 , although the correlations in this borderline case are tiny.

  12. Racial Stereotypes and the Art of Kara Walker Stéréotypes raciaux dans l’art de Kara Walker

    Directory of Open Access Journals (Sweden)

    Monika Seidl

    2009-07-01

    Full Text Available L’artiste afro-américaine Kara Walker (1969- travaille principalement sur les silhouettes découpées, forme d’art des XVIIIe et XIXe siècles qui était alors utilisée pour les portraits, les caricatures et la décoration. Un grand nombre de critiques d’art, tout particulièrement Howardena Pindell, accuse Walker de renforcer les stéréotypes raciaux et de ne pas réussir à mettre le présent en relation avec le passé dans son travail. Cet article considère l’aspect humoristique du travail de Walker et défend l’idée que le rire est une pratique spatiale, en tant qu’expérience vécue, qui occupe une partie seulement de l’espace se trouvant entre les stéréotypes raciaux et la vie. Offrir une perspective ludique est une stratégie clé dans un contexte de recherche d’un espace à partir duquel il est possible de critiquer et d’analyser des imaginaires sociaux irréconciliables. La distorsion gênante de Walker se situe dans son insistance à aplanir les corps et donc à leur retirer tout espace, tout en les étalant littéralement en tant que projections sur une surface plane, accentuant de ce fait le coté dramatique du blanc et du noir. A première vue, les silhouettes de Walker semblent perpétuer un code dichotomique de la différence culturelle. Cependant, cet article montre que le troisième espace, celui du rire, exerce une force perturbatrice qui commente la politique de la représentation à partir des stéréotypes eux-mêmes. Cet argument est illustré par son panneau Safety Curtain I qui servit de rideau à l’Opéra de Vienne pendant l’hiver 1998-1999.

  13. Development and evaluation of low-cost walker with trunk support for senior citizen.

    Science.gov (United States)

    Poier, Paloma Hohmann; Godke, Francisco; Foggiatto, José Aguiomar; Ulbricht, Leandra

    2017-10-09

    Develop and evaluate a low-cost walker with trunk support for senior citizens. Two-stage descriptive study: development of a walker with trunk support and evaluation with fourth age senior citizens. Twenty-three fourth age senior citizens were selected. The evaluated criteria were the immediate influence of the walker on the static stabilometry with baropodometer and the evaluation of gait with accelerometers monitoring time and amplitude of the hip movement. There was a significant decrease in the body oscillation of senior citizens with the use of the developed walker, and there were changes in the joint amplitudes of the hip, but they were not significant. Using low-cost materials, it was possible to develop and equipment that met resistance and effectiveness requirements. The walker interfered in the balance of the senior citizens, reducing significantly the static body oscillation.

  14. Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner.

    Directory of Open Access Journals (Sweden)

    John Meshki

    Full Text Available U373MG astrocytoma cells endogenously express the full-length neurokinin 1 receptor (NK1R. Substance P (SP, the natural ligand for NK1R, triggers rapid and transient membrane blebbing and we report that these morphological changes have different dynamics and intracellular signaling as compared to the changes that we have previously described in HEK293-NK1R cells. In both cell lines, the SP-induced morphological changes are Gq-independent, and they require the Rho, Rho-associated coiled-coil kinase (ROCK signaling pathway. Using confocal microscopy we have demonstrated that tubulin is phosphorylated subsequent to cell stimulation with SP and that tubulin accumulates inside the blebs. Colchicine, a tubulin polymerization inhibitor, blocked SP-induced blebbing in U373MG but not in HEK293-NK1R cells. Although p21-activated kinase (PAK is expressed in both cell lines, SP induced rapid phosphorylation of PAK in U373MG, but failed to phosphorylate PAK in HEK293-NK1R cells. The cell-permeable Rho inhibitor C3 transferase inhibited SP-induced PAK phosphorylation, but the ROCK inhibitor Y27632 had no effect on PAK phosphorylation, suggesting that Rho activates PAK in a ROCK-independent manner. Our study demonstrates that SP triggers rapid changes in cell morphology mediated by distinct intracellular signaling mechanisms in U373MG versus HEK293-NK1R cells.

  15. States of low energy on Robertson-Walker spacetimes

    International Nuclear Information System (INIS)

    Olbermann, Heiner

    2007-01-01

    We construct a new class of physical states of the free Klein-Gordon field in Robertson-Walker spacetimes. This is done by minimizing the expectation value of smeared stress-energy. We get an explicit expression for the state depending on the smearing function. We call it a state of low energy. States of low energy are an improvement of the concept of adiabatic vacua on Robertson-Walker spacetimes. The latter are approximations of the former. It is shown that states of low energy are Hadamard states

  16. Auditory perception of a human walker.

    Science.gov (United States)

    Cottrell, David; Campbell, Megan E J

    2014-01-01

    When one hears footsteps in the hall, one is able to instantly recognise it as a person: this is an everyday example of auditory biological motion perception. Despite the familiarity of this experience, research into this phenomenon is in its infancy compared with visual biological motion perception. Here, two experiments explored sensitivity to, and recognition of, auditory stimuli of biological and nonbiological origin. We hypothesised that the cadence of a walker gives rise to a temporal pattern of impact sounds that facilitates the recognition of human motion from auditory stimuli alone. First a series of detection tasks compared sensitivity with three carefully matched impact sounds: footsteps, a ball bouncing, and drumbeats. Unexpectedly, participants were no more sensitive to footsteps than to impact sounds of nonbiological origin. In the second experiment participants made discriminations between pairs of the same stimuli, in a series of recognition tasks in which the temporal pattern of impact sounds was manipulated to be either that of a walker or the pattern more typical of the source event (a ball bouncing or a drumbeat). Under these conditions, there was evidence that both temporal and nontemporal cues were important in recognising theses stimuli. It is proposed that the interval between footsteps, which reflects a walker's cadence, is a cue for the recognition of the sounds of a human walking.

  17. Infinitesimal conformal closed transformations of de Sitter and Robertson-Walker cosmological spaces

    International Nuclear Information System (INIS)

    Sakoto, Moussa

    1976-01-01

    The infinitesimal conformal closed transfromations of de Sitter and Robertson-Walker cosmological spaces are determined and an interesting property of the current lines for Robertson-Walker spaces is given [fr

  18. Asymptotic shape of the region visited by an Eulerian walker.

    Science.gov (United States)

    Kapri, Rajeev; Dhar, Deepak

    2009-11-01

    We study an Eulerian walker on a square lattice, starting from an initial randomly oriented background using Monte Carlo simulations. We present evidence that, for a large number of steps N , the asymptotic shape of the set of sites visited by the walker is a perfect circle. The radius of the circle increases as N1/3, for large N , and the width of the boundary region grows as Nalpha/3, with alpha=0.40+/-0.06 . If we introduce stochasticity in the evolution rules, the mean-square displacement of the walker, approximately approximately N2nu, shows a crossover from the Eulerian (nu=1/3) to a simple random-walk (nu=1/2) behavior.

  19. LCP method for a planar passive dynamic walker based on an event-driven scheme

    Science.gov (United States)

    Zheng, Xu-Dong; Wang, Qi

    2018-06-01

    The main purpose of this paper is to present a linear complementarity problem (LCP) method for a planar passive dynamic walker with round feet based on an event-driven scheme. The passive dynamic walker is treated as a planar multi-rigid-body system. The dynamic equations of the passive dynamic walker are obtained by using Lagrange's equations of the second kind. The normal forces and frictional forces acting on the feet of the passive walker are described based on a modified Hertz contact model and Coulomb's law of dry friction. The state transition problem of stick-slip between feet and floor is formulated as an LCP, which is solved with an event-driven scheme. Finally, to validate the methodology, four gaits of the walker are simulated: the stance leg neither slips nor bounces; the stance leg slips without bouncing; the stance leg bounces without slipping; the walker stands after walking several steps.

  20. Helen M. Walker: Influential in 1929 and Still Cited Today.

    Science.gov (United States)

    Rice, Marti H.; Stallings, William M.

    Helen M. Walker contributed to the field of educational research and statistics during a 55-year career. Born in Iowa in 1891, Walker earned a bachelor's degree from Iowa Wesleyan College and taught high school mathematics for nine years. She then taught at the University of Kansas while doing graduate work. One source noted that she was the first…

  1. Assistive devices alter gait patterns in Parkinson disease: advantages of the four-wheeled walker.

    Science.gov (United States)

    Kegelmeyer, Deb A; Parthasarathy, Sowmya; Kostyk, Sandra K; White, Susan E; Kloos, Anne D

    2013-05-01

    Gait abnormalities are a hallmark of Parkinson's disease (PD) and contribute to fall risk. Therapy and exercise are often encouraged to increase mobility and decrease falls. As disease symptoms progress, assistive devices are often prescribed. There are no guidelines for choosing appropriate ambulatory devices. This unique study systematically examined the impact of a broad range of assistive devices on gait measures during walking in both a straight path and around obstacles in individuals with PD. Quantitative gait measures, including velocity, stride length, percent swing and double support time, and coefficients of variation were assessed in 27 individuals with PD with or without one of six different devices including canes, standard and wheeled walkers (two, four or U-Step). Data were collected using the GAITRite and on a figure-of-eight course. All devices, with the exception of four-wheeled and U-Step walkers significantly decreased gait velocity. The four-wheeled walker resulted in less variability in gait measures and had less impact on spontaneous unassisted gait patterns. The U-Step walker exhibited the highest variability across all parameters followed by the two-wheeled and standard walkers. Higher variability has been correlated with increased falls. Though subjects performed better on a figure-of-eight course using either the four-wheeled or the U-Step walker, the four-wheeled walker resulted in the most consistent improvement in overall gait variables. Laser light use on a U-Step walker did not improve gait measures or safety in figure-of-eight compared to other devices. Of the devices tested, the four-wheeled-walker offered the most consistent advantages for improving mobility and safety. Copyright © 2012 Elsevier B.V. All rights reserved.

  2. 78 FR 37706 - Safety Standards for Infant Walkers and Infant Swings

    Science.gov (United States)

    2013-06-24

    ... test procedure that is needed for testing certain style walkers; Two references to federal regulations... a new step to the test procedure that enables test laboratories to test certain styles of walkers... direct final rule. Although the Administrative Procedure Act (APA) generally requires notice and comment...

  3. On the existence of perturbed Robertson-Walker universes

    International Nuclear Information System (INIS)

    D'Eath, P.D.

    1976-01-01

    Solutions of the full nonlinear field equations of general relativity near the Robertson-Walker universes are examined, together with their relation to linearized perturbations. A method due to Choquet-Bruhat and Deser is used to prove existence theorems for solutions near Robertson-Walker constraint data of the constraint equations on a spacelike hypersurface. These theorems allow one to regard the matter fluctuations as independent quantities, ranging over certain function spaces. In the k=-1 case the existence theory describes perturbations which may vary within uniform bounds throughout space. When k=+1 a modification of the method leads to a theorem which clarifies some unusual features of these constraint perturbations. The k=0 existence theorem refers only to perturbations which die away at large distances. The connection between linearized constraint solutions and solutions of the full constraints is discussed. For k= +- 1 backgrounds, solutions of the linearized constraints are analyzed using transverse-traceless decompositions of symmetric tensors. Finally the time-evolution of perturbed constraint data and the validity of linearized perturbation theory for Robertson-Walker universes are considered

  4. Terrain Interaction With The Quarter Scale Beam Walker

    Science.gov (United States)

    Chun, Wendell H.; Price, R. S.; Spiessbach, Andrew J.

    1990-03-01

    Frame walkers are a class of mobile robots that are robust and capable mobility platforms. Variations of the frame walker robot are in commercial use today. Komatsu Ltd. of Japan developed the Remotely Controlled Underwater Surveyor (ReCUS) and Normed Shipyards of France developed the Marine Robot (RM3). Both applications of the frame walker concept satisfied robotic mobility requirements that could not be met by a wheeled or tracked design. One vehicle design concept that falls within this class of mobile robots is the walking beam. A one-quarter scale prototype of the walking beam was built by Martin Marietta to evaluate the potential merits of utilizing the vehicle as a planetary rover. The initial phase of prototype rover testing was structured to evaluate the mobility performance aspects of the vehicle. Performance parameters such as vehicle power, speed, and attitude control were evaluated as a function of the environment in which the prototype vehicle was tested. Subsequent testing phases will address the integrated performance of the vehicle and a local navigation system.

  5. Terrain interaction with the quarter scale beam walker

    Science.gov (United States)

    Chun, Wendell H.; Price, S.; Spiessbach, A.

    1990-01-01

    Frame walkers are a class of mobile robots that are robust and capable mobility platforms. Variations of the frame walker robot are in commercial use today. Komatsu Ltd. of Japan developed the Remotely Controlled Underwater Surveyor (ReCUS) and Normed Shipyards of France developed the Marine Robot (RM3). Both applications of the frame walker concept satisfied robotic mobility requirements that could not be met by a wheeled or tracked design. One vehicle design concept that falls within this class of mobile robots is the walking beam. A one-quarter scale prototype of the walking beam was built by Martin Marietta to evaluate the potential merits of utilizing the vehicle as a planetary rover. The initial phase of prototype rover testing was structured to evaluate the mobility performance aspects of the vehicle. Performance parameters such as vehicle power, speed, and attitude control were evaluated as a function of the environment in which the prototype vehicle was tested. Subsequent testing phases will address the integrated performance of the vehicle and a local navigation system.

  6. Vacuum quantum effect for curved boundaries in static Robertson-Walker space-time

    International Nuclear Information System (INIS)

    Setare, M.R.; Sadeghi, J.

    2009-01-01

    The energy-momentum tensor for a massless conformally coupled scalar field in the region between two curved boundaries in k=-1 static Robertson-Walker space-time is investigated. We assume that the scalar field satisfies the Dirichlet boundary condition on the boundaries. k=-1 Robertson-Walker space is conformally related to the Rindler space, as a result we can obtain vacuum expectation values of energy-momentum tensor for conformally invariant field in Robertson-Walker space from the corresponding Rindler counterpart by the conformal transformation.

  7. Dandy walker variant and bipolar I disorder with graphomania.

    Science.gov (United States)

    Can, Serdar Suleyman; Karakaş Uğurlu, Görkem; Cakmak, Selcen

    2014-07-01

    Cerebellum is known to play an important role in coordination and motor functions. In some resent studies it is also considered to be involved in modulation of mood, cognition and psychiatric disorders. Dandy Walker Malformation is a congenital malformation that is characterized by hypoplasia or aplasia of the cerebellar vermis, cystic dilatation of the fourth ventricle and enlargement of the posterior fossa. When the volume of posterior fossa is normal, the malformation is called Dandy Walker Variant. Case is a 32 year old male with a 12 year history of Bipolar I Disorder presented with manic and depresive symptoms, including dysphoric and depressive affect, anhedonia, suicidal thoughts and behaviours, thoughts of fear about future, overtalkativeness and graphomania, increased energy, irregular sleep, loss of appetite, increased immersion in projects, irritability, agressive behavior, impulsivity. Cranial Magnetic Resonance Imaging was compatible to the morphological features of Dandy Walker Variant.

  8. A Case Report of Hodgkin’s Lymphoma in a Patient with Carcinosarcoma of the Bladder

    Directory of Open Access Journals (Sweden)

    Anthony Perre

    2011-12-01

    Full Text Available The screening of patients with a known primary extrathoracic malignancy for pulmonary metastasis may result in the identification of solitary or multiple pulmonary nodules. Radiologic features of these pulmonary nodules may suggest a diagnosis, but these features cannot reliably distinguish between benign and malignant etiologies. We present the case of a patient, diagnosed with carcinosarcoma of the bladder, who was found to have multiple pulmonary nodules by CT evaluation. Physical examination of the patient demonstrated the presence of cervical and axillary lymphadenopathy. An excisional biopsy of an axillary lymph node confirmed the diagnosis of Hodgkin’s lymphoma. This case report demonstrates that radiographic information obtained by CT scan must be carefully correlated with the history and physical examination of the patient. This case report also demonstrates the importance of diagnostic biopsy of pulmonary nodularity discovered in patients with a known primary extrathoracic malignancy. The assumption that these pulmonary nodules represented metastatic malignancies would have had crucial prognostic and therapeutic implications.

  9. Network formation determined by the diffusion process of random walkers

    International Nuclear Information System (INIS)

    Ikeda, Nobutoshi

    2008-01-01

    We studied the diffusion process of random walkers in networks formed by their traces. This model considers the rise and fall of links determined by the frequency of transports of random walkers. In order to examine the relation between the formed network and the diffusion process, a situation in which multiple random walkers start from the same vertex is investigated. The difference in diffusion rate of random walkers according to the difference in dimension of the initial lattice is very important for determining the time evolution of the networks. For example, complete subgraphs can be formed on a one-dimensional lattice while a graph with a power-law vertex degree distribution is formed on a two-dimensional lattice. We derived some formulae for predicting network changes for the 1D case, such as the time evolution of the size of nearly complete subgraphs and conditions for their collapse. The networks formed on the 2D lattice are characterized by the existence of clusters of highly connected vertices and their life time. As the life time of such clusters tends to be small, the exponent of the power-law distribution changes from γ ≅ 1-2 to γ ≅ 3

  10. Bleb Analysis and Short-Term Results of Biodegradable Collagen Matrix-Augmented Ahmed Glaucoma Valve Implantation: 6-Month Follow-up.

    Science.gov (United States)

    Rho, Seungsoo; Sung, Youngje; Ma, Kyoung Tak; Rho, Sae Heun; Kim, Chan Yun

    2015-09-01

    To evaluate the short-term efficacy of a biodegradable collagen matrix (BCM) as an adjuvant for Ahmed valve implantation surgery to prevent the hypertensive phase. This prospective study included 43 refractory glaucoma eyes, all followed for 6 months. Refractory glaucoma was defined as an IOP higher than 20 mm Hg with antiglaucoma eye drops without previous glaucoma surgery. Conventional method was performed in 21 eyes and BCM-augmented Ahmed valve implantation (BAAVI) in 22 eyes. In the BAAVI group, a 10 × 10 × 2-mm BCM was sutured on an Ahmed glaucoma valve FP7 model. Complete success was defined as an IOP of 21 mm Hg or lower (target IOP 1) or 17 mm Hg or lower (target IOP 2) without antiglaucoma medications and qualified success as an IOP of 21 mm Hg or lower with or without medications. Maximal bleb thickness was measured using anterior segment optical coherence tomography images. The preoperative IOPs and numbers of preoperative antiglaucoma medications were similar for both groups. Complete target IOP 1 success rates were 38.1% and 86.4%, complete target IOP 2 success rates were 19.0% and 59.1%, and qualified success rates were 52.4% and 90.9% in the conventional and BAAVI groups, respectively (P < 0.05). The hypertensive phase rate was lower in the BAAVI group (4.5% vs. 47.6%, P = 0.002). Maximal bleb thickness was increased in the BAAVI group on postoperative days 30 and 180 (P < 0.05). Success rates were higher in the BAAVI group than in the conventional group with the change of bleb morphology. Furthermore, use of BCM significantly decreased the need for antiglaucoma medications for at least 6 months postoperatively.

  11. CommWalker: correctly evaluating modules in molecular networks in light of annotation bias.

    Science.gov (United States)

    Luecken, M D; Page, M J T; Crosby, A J; Mason, S; Reinert, G; Deane, C M

    2018-03-15

    Detecting novel functional modules in molecular networks is an important step in biological research. In the absence of gold standard functional modules, functional annotations are often used to verify whether detected modules/communities have biological meaning. However, as we show, the uneven distribution of functional annotations means that such evaluation methods favor communities of well-studied proteins. We propose a novel framework for the evaluation of communities as functional modules. Our proposed framework, CommWalker, takes communities as inputs and evaluates them in their local network environment by performing short random walks. We test CommWalker's ability to overcome annotation bias using input communities from four community detection methods on two protein interaction networks. We find that modules accepted by CommWalker are similarly co-expressed as those accepted by current methods. Crucially, CommWalker performs well not only in well-annotated regions, but also in regions otherwise obscured by poor annotation. CommWalker community prioritization both faithfully captures well-validated communities and identifies functional modules that may correspond to more novel biology. The CommWalker algorithm is freely available at opig.stats.ox.ac.uk/resources or as a docker image on the Docker Hub at hub.docker.com/r/lueckenmd/commwalker/. deane@stats.ox.ac.uk. Supplementary data are available at Bioinformatics online.

  12. A New Controller for a Smart Walker Based on Human-Robot Formation.

    Science.gov (United States)

    Valadão, Carlos; Caldeira, Eliete; Bastos-Filho, Teodiano; Frizera-Neto, Anselmo; Carelli, Ricardo

    2016-07-19

    This paper presents the development of a smart walker that uses a formation controller in its displacements. Encoders, a laser range finder and ultrasound are the sensors used in the walker. The control actions are based on the user (human) location, who is the actual formation leader. There is neither a sensor attached to the user's body nor force sensors attached to the arm supports of the walker, and thus, the control algorithm projects the measurements taken from the laser sensor into the user reference and, then, calculates the linear and angular walker's velocity to keep the formation (distance and angle) in relation to the user. An algorithm was developed to detect the user's legs, whose distances from the laser sensor provide the information necessary to the controller. The controller was theoretically analyzed regarding its stability, simulated and validated with real users, showing accurate performance in all experiments. In addition, safety rules are used to check both the user and the device conditions, in order to guarantee that the user will not have any risks when using the smart walker. The applicability of this device is for helping people with lower limb mobility impairments.

  13. Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

    International Nuclear Information System (INIS)

    Miao, Xue-Rong; Gao, Xiao-Fei; Wu, Jing-Xiang; Lu, Zhi-Jie; Huang, Zhang-Xiang; Li, Xiao-Qing; He, Cheng; Yu, Wei-Feng

    2010-01-01

    Rapid and effective treatment of cancer-induced bone pain remains a clinical challenge and patients with bone metastasis are more likely to experience severe pain. The voltage-gated sodium channel Nav1.8 plays a critical role in many aspects of nociceptor function. Therefore, we characterized a rat model of cancer pain and investigated the potential role of Nav1.8. Adult female Wistar rats were used for the study. Cancer pain was induced by inoculation of Walker 256 breast carcinosarcoma cells into the tibia. After surgery, mechanical and thermal hyperalgesia and ambulation scores were evaluated to identify pain-related behavior. We used real-time RT-PCR to determine Nav1.8 mRNA expression in bilateral L4/L5 dorsal root ganglia (DRG) at 16-19 days after surgery. Western blotting and immunofluorescence were used to compare the expression and distribution of Nav1.8 in L4/L5 DRG between tumor-bearing and sham rats. Antisense oligodeoxynucleotides (ODNs) against Nav1.8 were administered intrathecally at 14-16 days after surgery to knock down Nav1.8 protein expression and changes in pain-related behavior were observed. Tumor-bearing rats exhibited mechanical hyperalgesia and ambulatory-evoked pain from day 7 after inoculation of Walker 256 cells. In the advanced stage of cancer pain (days 16-19 after surgery), normalized Nav1.8 mRNA levels assessed by real-time RT-PCR were significantly lower in ipsilateral L4/L5 DRG of tumor-bearing rats compared with the sham group. Western-blot showed that the total expression of Nav1.8 protein significantly decreased bilaterally in DRG of tumor-bearing rats. Furthermore, as revealed by immunofluorescence, only the expression of Nav1.8 protein in small neurons down regulated significantly in bilateral DRG of cancer pain rats. After administration of antisense ODNs against Nav1.8, Nav1.8 protein expression decreased significantly and tumor-bearing rats showed alleviated mechanical hyperalgesia and ambulatory-evoked pain. These

  14. Vertical force and wrist deviation angle when using a walker to stand up and sit down.

    Science.gov (United States)

    Leung, Cherng-Yee; Yeh, Po-Chan

    2011-08-01

    Research investigating walkers suggests that safety and assistance for the elderly with weak lower limbs were important. However, the relationship between the use of a walker and the upper limbs has received little investigation. Standing up and sitting down are important daily activities. Therefore, the aim of this study was to explore wrist deviation and vertical force among elderly individuals using a walker for assistance to stand up and sit down. In total, 64 elderly volunteers (M age = 80.22, SD = 9.36) were enrolled. Data were obtained from four load cells and a twin-axis wrist goniometer. Wrist deviation and vertical force were examined when participants used a walker with horizontal handles to assist in standing up and sitting down. Significant wrist angle deviation occurred with the use of a walker, with dorsiflexion of the right hand greater than that of the left. Males exerted significantly greater vertical force. In the sitting position, greater ulnar deviation was seen among experienced walker users, whereas during standing, experienced users exhibited greater dorsiflexion. The horizontal handles of most marketed walkers may cause user wrist deviations, suggesting researchers should pursue improvements in walker design.

  15. Dataset reporting the perceiver identification rates of basic emotions expressed by male, female and ambiguous gendered walkers in full-light, point-light and synthetically modelled point-light walkers.

    Science.gov (United States)

    Halovic, Shaun; Kroos, Christian

    2017-12-01

    This data set describes the experimental data collected and reported in the research article "Walking my way? Walker gender and display format confounds the perception of specific emotions" (Halovic and Kroos, in press) [1]. The data set represent perceiver identification rates for different emotions (happiness, sadness, anger, fear and neutral), as displayed by full-light, point-light and synthetic point-light walkers. The perceiver identification scores have been transformed into H t rates, which represent proportions/percentages of correct identifications above what would be expected by chance. This data set also provides H t rates separately for male, female and ambiguously gendered walkers.

  16. Walking my way? Walker gender and display format Confounds the perception of specific emotions.

    Science.gov (United States)

    Halovic, Shaun; Kroos, Christian

    2018-02-01

    Previous evidence has shown that males and females display different gait kinematics which may influence the perception of emotions displayed through the same walking gait. We therefore investigated the influence of walker gender on the perception of happiness, sadness, anger and fear displayed through walking movements. Full-light (FL), point-light (PL) and synthetically modelled point-light walkers (SW) of both genders were shown to perceivers over three experiments. Additionally, gender ambiguous synthetic walkers were shown to control for the influence of form, gender stereotypes and idiosyncratic gait movements on emotional gait perception. Each emotion was identified above chance level for both walker genders and in all display conditions though significantly less in PL and SW than in FL. The gender of the walker did not influence the pattern of identifications in FL walkers (Fear > Sad > Happy > Anger > Neutral), but did influence the identification patterns in PL (Female: [Happy = Sad = Fear = Anger] > Neutral; Male: Fear = Sad = [Happy > Anger] > Neutral) and SWs (Female: Happy = Sad = Anger = Fear = Neutral; Male: [Happy = Sad = Anger] > [Fear = Neutral]; Ambiguous: [[Happy = Sad = Anger] > Fear] = Neutral). The gender of the walker and format in which they are displayed influenced the perception of different basic emotions. The constructed SW stimuli also displayed happiness, sadness and anger with equivalent intensity in female, male and gender ambiguous walkers thus untangling the perception-expression entanglement that has plagued previous emotion perception research. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

  17. [Effect of abducens orthosis combined with walker on developmental dysplasia of the hip].

    Science.gov (United States)

    Hu, Zhiyong; Xu, Yongqiang; Liang, Jieyu; Li, Kanghua; Liao, Qiande

    2009-07-01

    To evaluate the effect of abducens orthosis combined with walker on developmental dysplasia of the hip (DDH). A total of 126 patients (224 hips) with DDH aged 6-36 months in Xiangya Hospital was randomly divided into 2 groups: an orthosis combined with walker group and an improved hip frog cast fixation group. Seventy patients (130 hips) were treated by the orthosis combined with walker and 56 patients (94 hips) were treated by the improved hip frog cast fixation. We compared the effect and complications of the 2 groups. The fineness rates of the orthosis combined with walker group and the improved hip frog cast fixation group were 89.2% and 90.4%, respectively, with no significant difference (P>0.05). The rate of femoral head osteonecrosis in the orthosis combined with walker group was significantly lower than that in the improved hip frog cast fixation group (1.5% vs. 5.3%,Pwalker has a lower proportion of femoral head osteonecrosis, but a higher proportion of re-dislocation.

  18. Simulation of the Lower Walker River Basin hydrologic system, west-central Nevada, using PRMS and MODFLOW models

    Science.gov (United States)

    Allander, Kip K.; Niswonger, Richard G.; Jeton, Anne E.

    2014-01-01

    Walker Lake is a terminal lake in west-central Nevada with almost all outflow occurring through evaporation. Diversions from Walker River since the early 1900s have contributed to a substantial reduction in flow entering Walker Lake. As a result, the lake is receding, and salt concentrations have increased to a level in which Oncorhynchus clarkii henshawi (Lahontan Cutthroat trout) are no longer present, and the lake ecosystem is threatened. Consequently, there is a concerted effort to restore the Walker Lake ecosystem and fishery to a level that is more sustainable. However, Walker Lake is interlinked with the lower Walker River and adjacent groundwater system which makes it difficult to understand the full effect of upstream water-management actions on the overall hydrologic system including the lake level, volume, and dissolved-solids concentrations of Walker Lake. To understand the effects of water-management actions on the lower Walker River Basin hydrologic system, a watershed model and groundwater flow model have been developed by the U.S. Geological Survey in cooperation with the Bureau of Reclamation and the National Fish and Wildlife Foundation.

  19. Walker Branch Watershed Vegetation Inventory, 1967-1997

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: The original objectives of the long-term vegetation survey of Walker Branch Watershed in eastern Tennessee (WBW; Curlin and Nelson 1968) was to quantify...

  20. Usher syndrome associated with a variant of Dandy-Walker malformation.

    Science.gov (United States)

    Simsek, Tulay; Ozdamar, Yasemin; Simsek, Enver; Men, Gamze

    2010-05-21

    Three cases of Usher syndrome associated with a variant of Dandy-Walker malformation in three siblings from consanguineous Turkish parents are described. The siblings had retinitis pigmentosa and hearing loss. Two of the siblings also had mental retardation, which is not a constant finding in Usher syndrome. Dandy-Walker malformation might have contributed to the mental retardation in two of these patients and might be a coincidental finding with Usher syndrome. Copyright 2010, SLACK Incorporated.

  1. Casimir densities for a boundary in Robertson-Walker spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Saharian, A.A., E-mail: saharian@ictp.i [Department of Physics, Yerevan State University, 1 Alex Manoogian Street, 0025 Yerevan (Armenia); Setare, M.R., E-mail: rezakord@ipm.i [Department of Science of Bijar, University of Kurdistan, Bijar (Iran, Islamic Republic of)

    2010-04-12

    For scalar and electromagnetic fields we evaluate the vacuum expectation value of the energy-momentum tensor induced by a curved boundary in the Robertson-Walker spacetime with negative spatial curvature. In order to generate the vacuum densities we use the conformal relation between the Robertson-Walker and Rindler spacetimes and the corresponding results for a plate moving by uniform proper acceleration through the Fulling-Rindler vacuum. For the general case of the scale factor the vacuum energy-momentum tensor is presented as the sum of the boundary free and boundary induced parts.

  2. Casimir densities for a boundary in Robertson-Walker spacetime

    International Nuclear Information System (INIS)

    Saharian, A.A.; Setare, M.R.

    2010-01-01

    For scalar and electromagnetic fields we evaluate the vacuum expectation value of the energy-momentum tensor induced by a curved boundary in the Robertson-Walker spacetime with negative spatial curvature. In order to generate the vacuum densities we use the conformal relation between the Robertson-Walker and Rindler spacetimes and the corresponding results for a plate moving by uniform proper acceleration through the Fulling-Rindler vacuum. For the general case of the scale factor the vacuum energy-momentum tensor is presented as the sum of the boundary free and boundary induced parts.

  3. Neutral signature Walker-VSI metrics

    International Nuclear Information System (INIS)

    Coley, A; McNutt, D; Musoke, N; Brooks, D; Hervik, S

    2014-01-01

    We will construct explicit examples of four-dimensional neutral signature Walker (but not necessarily degenerate Kundt) spaces for which all of the polynomial scalar curvature invariants vanish. We then investigate the properties of some particular subclasses of Ricci flat spaces. We also briefly describe some four-dimensional neutral signature Einstein spaces for which all of the polynomial scalar curvature invariants are constant. (paper)

  4. Anterior or posterior walkers for children with cerebral palsy? A systematic review.

    Science.gov (United States)

    Poole, Marilyn; Simkiss, Doug; Rose, Alice; Li, François-Xavier

    2018-05-01

    To review the literature comparing use of anterior and posterior walkers (PW's) by children with cerebral palsy (CP) to determine which walker type is preferable. Electronic databases were searched using pre-defined terms by two independent reviewers. Reference lists of included studies were hand searched. Studies published between 1985 and 2016 comparing use of anterior and PW's by children with CP were included. All study designs and outcomes were accepted. Risk of bias was assessed using the "Quality assessment standard for a cross-over study". Quality of evidence was evaluated using GRADE. Six studies were analysed. All studies had small sample sizes. A total of 4/6 studies were randomized. A total of 4/6 had high risk of bias. Outcomes included velocity, pelvic tilt, hip flexion, knee flexion, step length, stride length, cadence, double stance time, oxygen cost and participant/parental preference. Velocity, trunk flexion/pelvic tilt, and stability may be improved by using a PW, however, GRADE quality was very low for all outcomes and there was heterogeneity between studies. The majority of participants and parents preferred the PW. Heterogeneity and low quality of existing evidence prevented recommendation of one walker type. Well-designed studies with adequate power are needed to inform clinical recommendations. Implications for rehabilitation Clinical recommendations cannot be made for whether anterior or posterior walkers are preferable for children with cerebral palsy based on the existing evidence. Velocity, trunk flexion/pelvic tilt, and stability may be improved by using a posterior walker. The majority of walking aid users and their parents preferred posterior walkers. Adequately powered studies designed to minimize bias are needed.

  5. The fire-walker's high: affect and physiological responses in an extreme collective ritual.

    Directory of Open Access Journals (Sweden)

    Ronald Fischer

    Full Text Available How do people feel during extreme collective rituals? Despite longstanding speculation, few studies have attempted to quantify ritual experiences. Using a novel pre/post design, we quantified physiological fluctuations (heart rates and self-reported affective states from a collective fire-walking ritual in a Mauritian Hindu community. Specifically, we compared changes in levels of happiness, fatigue, and heart rate reactivity among high-ordeal participants (fire-walkers, low-ordeal participants (non-fire-walking participants with familial bonds to fire-walkers and spectators (unrelated/unknown to the fire-walkers. We observed that fire-walkers experienced the highest increase in heart rate and reported greater happiness post-ritual compared to low-ordeal participants and spectators. Low-ordeal participants reported increased fatigue after the ritual compared to both fire-walkers and spectators, suggesting empathetic identification effects. Thus, witnessing the ritualistic suffering of loved ones may be more exhausting than experiencing suffering oneself. The findings demonstrate that the level of ritual involvement is important for shaping affective responses to collective rituals. Enduring a ritual ordeal is associated with greater happiness, whereas observing a loved-one endure a ritual ordeal is associated with greater fatigue post-ritual.

  6. Corrections to the Walker-Thompson estimate of the cascade volume

    International Nuclear Information System (INIS)

    Swaminarayan, S.; Nastasi, M.

    2009-01-01

    Sigmund [P. Sigmund, Appl. Phys. Lett. 25 (1974) 169] analytically predicted that the ratio of cascade volume to energy distribution volume should follow a universal curve that is sigmoidal in shape. Subsequent Monte Carlo simulations by Walker and Thompson [R.S. Walker, D.A. Thompson, Radiat. Eff. 37 (1978) 113] showed that although this curve is sigmoidal in shape, the curve is different for different materials with large deviations from Sigmund's prediction at high M 2 /M 1 . Our analysis of the Walker and Thompson approach has revealed an error in the analytical equations used. A correct analysis of volume ratios using a different set of equations is presented. Analysis of data produced by SRIM [J.F. Ziegler, J.P. Biersack, U. Littmark, in: The Stopping and Range of Ions in solids, Pergamon, New York, 1985] (Monte Carlo) simulations gives results that are in good agreement with Sigmund's predictions.

  7. Does the Walker Lane extend through the Nevada test site region?

    International Nuclear Information System (INIS)

    Fridrich, C.; O'Leary, D.

    1993-01-01

    The southeastern terminus of the Walker Lane is poorly defined and poorly understood. Recent work in and around the Nevada Test Site (NTS) suggests the presence of a structural zone that may be an extension of the Walker Lane, and that may be continuous with the Las Vegas valley shear zone farther to the southeast. Unlike the Walker Lane, large through-going strike-slip faults have not been found in the NTS zone. Instead, the strike-slip faults present are few, are relatively short, commonly consist of diffuse fault zones, are interconnected poorly if at all, and largely appear to represent zones of accommodation between domains in which extension occurred at different times and to different degrees. However, the majority of these right-slip and left-slip faults are northwest-trending and northeast-trending, respectively, suggesting that plate motions may have played a role in the creation of these accommodation zones. An obstacle to understanding the NTS zone is that major ignimbrite sheets and calderas of the southwestern Nevada volcanic field (SNVF) formed in this zone at the height of late Tertiary tectonic activity, possibly burying much of the structural evidence. The NTS zone could represent an intersection of the Walker Lane with another major structural feature, a significant bend in the Walker Lane, or a transtensional tear that localized accommodation structures as well as the prominent late Miocene calderas of the SNVF. Ongoing field work is aimed at determining which of these and competing interpretations is best

  8. Jejunal intussusception in a 10-year-old boy with blue rubber bleb nevus syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Beluffi, Giampiero [Section of Paediatric Radiology, Department of Radiodiagnosis, IRCCS Policlinico S. Matteo, Piazzale Golgi, 2, 27100, Pavia PV (Italy); Romano, Piero; Matteotti, Chiara; Minniti, Silvio; Ceffa, Franco [Division of Paediatric Surgery, IRCCS Policlinico S. Matteo, Pavia (Italy); Morbini, Patrizia [Department of Pathology, IRCCS Policlinico S. Matteo, Pavia (Italy)

    2004-09-01

    Jejunal intussusception in a Chinese 10-year-old boy affected by the blue rubber bleb nevus syndrome is presented and discussed. The syndrome is rare, sporadically found with possible dominant inheritance, and due to a gene mutation mapped on the short arm of chromosome 9. It presents with distinctive cutaneous and gastrointestinal malformations together with possible other organ involvement. Gastrointestinal malformations tend to bleed and lead to anaemia. Infrequent complications of the gastrointestinal malformations are volvulus, intestinal infarction and intussusception. The age of the patient and the jejunal intussusception precipitated by a vascular malformation containing calcifications (which were also found in different gut segments) make this case remarkable. (orig.)

  9. Jejunal intussusception in a 10-year-old boy with blue rubber bleb nevus syndrome

    International Nuclear Information System (INIS)

    Beluffi, Giampiero; Romano, Piero; Matteotti, Chiara; Minniti, Silvio; Ceffa, Franco; Morbini, Patrizia

    2004-01-01

    Jejunal intussusception in a Chinese 10-year-old boy affected by the blue rubber bleb nevus syndrome is presented and discussed. The syndrome is rare, sporadically found with possible dominant inheritance, and due to a gene mutation mapped on the short arm of chromosome 9. It presents with distinctive cutaneous and gastrointestinal malformations together with possible other organ involvement. Gastrointestinal malformations tend to bleed and lead to anaemia. Infrequent complications of the gastrointestinal malformations are volvulus, intestinal infarction and intussusception. The age of the patient and the jejunal intussusception precipitated by a vascular malformation containing calcifications (which were also found in different gut segments) make this case remarkable. (orig.)

  10. Cochlear implantation in patient with Dandy-walker syndrome.

    Science.gov (United States)

    de Oliveira, Adriana Kosma Pires; Hamerschmidt, Rogerio; Mocelin, Marcos; Rezende, Rodrigo K

    2012-07-01

     Dandy Walker Syndrome is a congenital abnormality in the central nervous system, characterized by a deficiency in the development of middle cerebelar structures, cystic dilatation of the posterior pit communicating with the fourth ventricle and upward shift of the transverse sinuses, tentorium and dyes. Among the clinical signs are occipital protuberances, a progressive increase of the skull, bowing before the fontanels, papilledema, ataxia, gait disturbances, nystagmus, and intellectual impairment.  To describe a case of female patient, 13 years old with a diagnosis of this syndrome and bilateral hearing loss underwent cochlear implant surgery under local anesthesia and sedation.  CGS, 13 years old female was referred to the Otolaryngological Department of Otolaryngology Institute of Parana with a diagnosis of "Dandy-Walker syndrome" for Otolaryngological evaluation for bilateral hearing loss with no response to the use of hearing aids. Final Comments: The field of cochlear implants is growing rapidly. We believe that the presence of Dandy-Walker syndrome cannot be considered a contraindication to the performance of cochlear implant surgery, and there were no surgical complications due to neurological disorders with very favorable results for the patient who exhibits excellent discrimination. It has less need for lip reading with improvement in speech quality.

  11. Cochlear implantation in patient with Dandy-walker syndrome

    Directory of Open Access Journals (Sweden)

    Oliveira, Adriana Kosma Pires de

    2012-01-01

    Full Text Available Introduction: Dandy Walker Syndrome is a congenital abnormality in the central nervous system, characterized by a deficiency in the development of middle cerebelar structures, cystic dilatation of the posterior pit communicating with the fourth ventricle and upward shift of the transverse sinuses, tentorium and dyes. Among the clinical signs are occipital protuberances, a progressive increase of the skull, bowing before the fontanels, papilledema, ataxia, gait disturbances, nystagmus, and intellectual impairment. Objectives: To describe a case of female patient, 13 years old with a diagnosis of this syndrome and bilateral hearing loss underwent cochlear implant surgery under local anesthesia and sedation. Case Report: CGS, 13 years old female was referred to the Otolaryngological Department of Otolaryngology Institute of Parana with a diagnosis of "Dandy-Walker syndrome" for Otolaryngological evaluation for bilateral hearing loss with no response to the use of hearing aids. Final Comments: The field of cochlear implants is growing rapidly. We believe that the presence of Dandy-Walker syndrome cannot be considered a contraindication to the performance of cochlear implant surgery, and there were no surgical complications due to neurological disorders with very favorable results for the patient who exhibits excellent discrimination. It has less need for lip reading with improvement in speech quality.

  12. Neurokinin 1 Receptor Mediates Membrane Blebbing and Sheer Stress-Induced Microparticle Formation in HEK293 Cells

    Science.gov (United States)

    Chen, Panpan; Douglas, Steven D.; Meshki, John; Tuluc, Florin

    2012-01-01

    Cell-derived microparticles participate in intercellular communication similar to the classical messenger systems of small and macro-molecules that bind to specialized membrane receptors. Microparticles have been implicated in the regulation of a variety of complex physiopathologic processes, such as thrombosis, the control of innate and adaptive immunity, and cancer. The neurokinin 1 receptor (NK1R) is a Gq-coupled receptor present on the membrane of a variety of tissues, including neurons in the central and peripheral nervous system, immune cells, endocrine and exocrine glands, and smooth muscle. The endogenous agonist of NK1R is the undecapeptide substance P (SP). We have previously described intracellular signaling mechanisms that regulate NK1R-mediated rapid cell shape changes in HEK293 cells and U373MG cells. In the present study, we show that the activation of NK1R in HEK293 cells, but not in U373MG cells, leads to formation of sheer-stress induced microparticles that stain positive with the membrane-selective fluorescent dye FM 2–10. SP-induced microparticle formation is independent of elevated intracellular calcium concentrations and activation of NK1R present on HEK293-derived microparticles triggers detectable calcium increase in SP-induced microparticles. The ROCK inhibitor Y27632 and the dynamin inhibitor dynasore inhibited membrane blebbing and microparticle formation in HEK293 cells, strongly suggesting that microparticle formation in this cell type is dependent on membrane blebbing. PMID:23024816

  13. Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells.

    Directory of Open Access Journals (Sweden)

    Panpan Chen

    Full Text Available Cell-derived microparticles participate in intercellular communication similar to the classical messenger systems of small and macro-molecules that bind to specialized membrane receptors. Microparticles have been implicated in the regulation of a variety of complex physiopathologic processes, such as thrombosis, the control of innate and adaptive immunity, and cancer. The neurokinin 1 receptor (NK1R is a Gq-coupled receptor present on the membrane of a variety of tissues, including neurons in the central and peripheral nervous system, immune cells, endocrine and exocrine glands, and smooth muscle. The endogenous agonist of NK1R is the undecapeptide substance P (SP. We have previously described intracellular signaling mechanisms that regulate NK1R-mediated rapid cell shape changes in HEK293 cells and U373MG cells. In the present study, we show that the activation of NK1R in HEK293 cells, but not in U373MG cells, leads to formation of sheer-stress induced microparticles that stain positive with the membrane-selective fluorescent dye FM 2-10. SP-induced microparticle formation is independent of elevated intracellular calcium concentrations and activation of NK1R present on HEK293-derived microparticles triggers detectable calcium increase in SP-induced microparticles. The ROCK inhibitor Y27632 and the dynamin inhibitor dynasore inhibited membrane blebbing and microparticle formation in HEK293 cells, strongly suggesting that microparticle formation in this cell type is dependent on membrane blebbing.

  14. Bistability and biasing effects in the perception of ambiguous point-light walkers.

    Science.gov (United States)

    Vanrie, Jan; Dekeyser, Mathias; Verfaillie, Karl

    2004-01-01

    The perceptually bistable character of point-light walkers has been examined in three experiments. A point-light figure without explicit depth cues constitutes a perfectly ambiguous stimulus: from all viewpoints, multiple interpretations are possible concerning the depth orientation of the figure. In the first experiment, it is shown that non-lateral views of the walker are indeed interpreted in two orientations, either as facing towards the viewer or as facing away from the viewer, but that the interpretation in which the walker is oriented towards the viewer is reported more frequently. In the second experiment the point-light figure was walking backwards, making the global orientation of the point-light figure opposite to the direction of global motion. The interpretation in which the walker was facing the viewer was again reported more frequently. The robustness of these findings was examined in the final experiment, in which the effects of disambiguating the stimulus by introducing a local depth cue (occlusion) or a more global depth cue (applying perspective projection) were explored.

  15. Compliant walker

    Science.gov (United States)

    Kerley, James J. (Inventor); Eklund, Wayne D. (Inventor); Crane, J. Allen (Inventor)

    1992-01-01

    A compliant walker is provided for humans having limited use of their legs and lower back. It includes an upright wheel frame which at least partially surrounds an upright user wearing a partial body harness. It is attached to the frame by means of cable compliant apparatus consisting of sets of cable segments and angle bracket members connected between opposite side members of the frame and adjacent side portions of the harness. Novelty is believed to exist in the combination of a wheeled frame including a side support structure, a body harness, and compliance means connecting the body harness to the side support structure for flexibility holding and supporting a person in a substantially upright position when the user sags in the frame when taking weight off the lower extremities.

  16. Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis Inibição do crescimento do carcinossarcoma 256 de Walker pelo extrato alcoólico de folhas de chá verde(Camellia sinensis

    Directory of Open Access Journals (Sweden)

    Mauriclécio Franco Ponte

    2012-09-01

    Full Text Available PURPOSE: To evaluate the antitumor activity of alcoholic extracts of green tea (Camella sinensis. METHODS: Four groups of six Wistar rats were inoculated intramuscularly with 10(6 Walker tumor cells/mL. During 10 days, the animals received by gavage either 0.9% saline solution (Group I; negative control, solution containing 20 mg/Kg of tamoxifen (Group II; positive control, solution containing 0.07 g/Kg alcoholic extract of C. sinensis (Group III, or solution containing 0.14 g/Kg alcoholic extract of C. sinensis (Group IV. Following euthanasia on the tenth day, the tumor, liver, kidneys and spleen were excised and weighed, and tumor volume and tumor growth inhibition were quantified. RESULTS: The average weight of the animals was greater in Group IV than in Group II (p=0.0107. Tumor weight was smaller in Group IV than in Group I (p=0.0062, but did not differ from Group II. Tumor volume was smaller in Groups II and IV than in Group I (p=0.0131. Tumor growth inhibition was observed in Groups II (44.67% ± 32.47, III (16.83% ± 53.02 and IV (66.4% ± 25.82 (p>0.05. The groups did not differ with regard to the weight of the excised organs. CONCLUSION: Alcoholic extracts of green tea have antitumor activity.OBJETIVO: Avaliar a atividade antitumoral do extrato alcoólico do chá verde (C. sinensis. MÉTODOS: Quatro grupos de seis ratos Wistar foram inoculados com 1x10(6 células/mL do tumor de Walker por via intramuscular. Os grupos foram tratados durante 10 dias, por gavagem, com salina 0,9 % (Grupo I, controle negativo, 20 mg/Kg de tamoxifeno (Grupo II, controle positivo e extrato alcoólico de C. sinensis nas doses de 0,07 g/Kg (Grupo III ou 0,14 g/Kg (Grupo IV. O volume e a inibição do crescimento tumoral foram calculados. RESULTADOS: A média dos pesos dos animais foi maior no Grupo IV do que no Grupo II (p=0,0107. O peso tumoral do Grupo IV foi menor do que o Grupo I (p=0,0062, mas não houve diferença quando comparado ao Grupo II. O volume

  17. [Needs, uses, cons-pros, good practices and opportunities about walker in elderly with loss of autonomy].

    Science.gov (United States)

    Mézière, Anthony; Schonheit, Claire; Moreau, Caroline; Baudry, Elodie; Monié, Marguerite; Piette, François; Curtis, Valentine; Pasqui, Viviane

    2015-01-01

    Non-use of the walker may be secondary to an initial inappropriate prescribing, a lack of adequate training, a lack of monitoring and side effects of using. Improving both stability and mobility in users is due to several biomechanical mechanisms. The benefits of walker are: general physiological effects, more confidence, better social life and decrease in the burden of care. The disadvantages of walker are: technical or practical aspects criticized by users, musculoskeletal disorders, delayed reaction time, fall risk and stigma. Few scientific data evaluating the interest of the walker concerning mobility exist, thus recommendations are low grade and are often taken from professional clinical experiences. The choice of technical walking assistance depends on the pathology and biomechanical mechanism. The walker robots are few distributed. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  18. Effect of uphill and downhill walking on walking performance in geriatric patients using a wheeled walker.

    Science.gov (United States)

    Lindemann, Ulrich; Schwenk, Michael; Schmitt, Syn; Weyrich, Michael; Schlicht, Wolfgang; Becker, Clemens

    2017-08-01

    Wheeled walkers are recommended to improve walking performance in older persons and to encourage and assist participation in daily life. Nevertheless, using a wheeled walker can cause serious problems in the natural environment. This study aimed to compare uphill and downhill walking with walking level in geriatric patients using a wheeled walker. Furthermore, we investigated the effect of using a wheeled walker with respect to dual tasking when walking level. A total of 20 geriatric patients (median age 84.5 years) walked 10 m at their habitual pace along a level surface, uphill and downhill, with and without a standard wheeled walker. Gait speed, stride length and cadence were assessed by wearable sensors and the walk ratio was calculated. When using a wheeled walker while walking level the walk ratio improved (0.58 m/[steps/min] versus 0.57 m/[steps/min], p = 0.023) but gait speed decreased (1.07 m/s versus 1.12 m/s, p = 0.020) when compared to not using a wheeled walker. With respect to the walk ratio, uphill and downhill walking with a wheeled walker decreased walking performance when compared to level walking (0.54 m/[steps/min] versus 0.58 m/[steps/min], p = 0.023 and 0.55 m/[steps/min] versus 0.58 m/[steps/min], p = 0.001, respectively). At the same time, gait speed decreased (0.079 m/s versus 1.07 m/s, p walker improved the quality of level walking but the performance of uphill and downhill walking was worse compared to walking level when using a wheeled walker.

  19. Influence of an infant walker on onset and quality of walking pattern of locomotion:an electromyographic investigation.

    Science.gov (United States)

    Kauffman, I B; Ridenour, M

    1977-12-01

    Acquisition of bipedal locomotor skill in human infants was studied electromyographically with regard to the deprivation or enrichment behavior resulting from the frequent and regular use of an infant walker. Subjects were six sets of male, fraternal twins. One randomly selected sibling from each set underwent a training program, commencing at the age of 300 days, spending a total of 2 hr. per day in a walker. Siblings not included in this group were subjected to no special training. EMG recordings were taken of all subjects at specified intervals in order to establish a model of the typical motor pattern at various stages of skill development. These data were then contrasted with EMG data similarly obtained from the walker-trained subjects. Use of an infant walker modified the mechanics of the infant's locomotion in a number of important ways. It was shown that use of the walker enables an infant to commit substantial mechanical errors yet succeed in bipedal locomotion. Inasmuch as the mechanics of walker-assisted and non-assisted bipedal locomotion are dissimilar in so many important ways, positive transfer from walker-training appears questionable.

  20. Directional transport of colloids inside a bath of self-propelling walkers.

    Science.gov (United States)

    Merlitz, Holger; Wu, Chenxu; Sommer, Jens-Uwe

    2017-05-24

    We present a setup in which passive colloids inside a solvent are moved to the boundaries of the container. The directional transport is facilitated by self-propelling microparticles ("walkers") with an activity gradient, which reduces their propulsion in the vicinity of bounding walls. An attractive interaction leads to the adsorption of walkers onto the colloid-surfaces in regions of low walker activity. It is shown that the activity gradient generates a free energy gradient which in turn acts as a driving force on the passive colloids. We carry out molecular dynamics simulations and present approaches to a theoretical description of the involved processes. Although the simulation data are not reproduced on a fully quantitative level, their qualitative features are covered by the model. The effect described here may be applied to facilitate a directional transport of drugs or to eliminate pollutants.

  1. 76 FR 13665 - Arcelor Mittal, Formerly Known as Mittal Steel Walker Wire, a Subsidiary of Arcelor Mittal...

    Science.gov (United States)

    2011-03-14

    ... Known as Mittal Steel Walker Wire, a Subsidiary of Arcelor Mittal--Montreal, Including On-Site Leased... Steel Walker Wire, a subsidiary of Arcelor Mittal-- Montreal, including on-site leased workers from... Walker Wire, Inc., Ferndale, Michigan, separated from employment on or after July 23, 2006 through August...

  2. Averaging Robertson-Walker cosmologies

    International Nuclear Information System (INIS)

    Brown, Iain A.; Robbers, Georg; Behrend, Juliane

    2009-01-01

    The cosmological backreaction arises when one directly averages the Einstein equations to recover an effective Robertson-Walker cosmology, rather than assuming a background a priori. While usually discussed in the context of dark energy, strictly speaking any cosmological model should be recovered from such a procedure. We apply the scalar spatial averaging formalism for the first time to linear Robertson-Walker universes containing matter, radiation and dark energy. The formalism employed is general and incorporates systems of multiple fluids with ease, allowing us to consider quantitatively the universe from deep radiation domination up to the present day in a natural, unified manner. Employing modified Boltzmann codes we evaluate numerically the discrepancies between the assumed and the averaged behaviour arising from the quadratic terms, finding the largest deviations for an Einstein-de Sitter universe, increasing rapidly with Hubble rate to a 0.01% effect for h = 0.701. For the ΛCDM concordance model, the backreaction is of the order of Ω eff 0 ≈ 4 × 10 −6 , with those for dark energy models being within a factor of two or three. The impacts at recombination are of the order of 10 −8 and those in deep radiation domination asymptote to a constant value. While the effective equations of state of the backreactions in Einstein-de Sitter, concordance and quintessence models are generally dust-like, a backreaction with an equation of state w eff < −1/3 can be found for strongly phantom models

  3. Future null infinity of Robertson-Walker spacetimes

    International Nuclear Information System (INIS)

    Moreschi, O.M.

    1988-08-01

    The future null infinity for all non-contracting Robertson-Walker space time is studied systematically. A theorem is proved which establishes the expected relation between the nature of J + and the appearance or absence of cosmic event horizons. (author). 7 refs, 1 tab

  4. Measuring cortical motor hemodynamics during assisted stepping - An fNIRS feasibility study of using a walker.

    Science.gov (United States)

    de Lima-Pardini, Andrea Cristina; Zimeo Morais, Guilherme A; Balardin, Joana Bisol; Coelho, Daniel Boari; Azzi, Nametala Maia; Teixeira, Luis Augusto; Sato, João Ricardo

    2017-07-01

    Walkers are commonly prescribed worldwide to individuals unable to walk independently. Walker usage leads to improved postural control and voluntary movement during step. In the present study, we aimed to provide a concept-proof on the feasibility of an event-related protocol integrating the analyses of biomechanical variables of step initiation and functional near-infrared spectroscopy (fNIRS) to measure activation of the supplementary motor area (SMA) while using a walker. Healthy young participants were tested while stepping with versus without the use of the walker. Behavioral analysis showed that anticipatory postural adjustments (APA) decreased when supporting the body weight on the walker. Delta (without-with) of activation magnitude of the muscle tibialis anterior was positively correlated to the delta of deoxyhemoglobin concentration changes in the SMA. The novelty of this study is the development of a protocol to assess brain function together with biomechanical analysis during the use of a walker. The method sheds light to the potential utility of combining fNIRS and biomechanical assessment during assistive step initiation, which can represent a new opportunity to study populations with mobility deficits. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Robust Redundant Input Reliable Tracking Control for Omnidirectional Rehabilitative Training Walker

    Directory of Open Access Journals (Sweden)

    Ping Sun

    2014-01-01

    Full Text Available The problem of robust reliable tracking control on the omnidirectional rehabilitative training walker is examined. The new nonlinear redundant input method is proposed when one wheel actuator fault occurs. The aim of the study is to design an asymptotically stable controller that can guarantee the safety of the user and ensure tracking on a training path planned by a physical therapist. The redundant degrees of freedom safety control and the asymptotically zero state detectable concept of the walker are presented, the model of redundant degree is constructed, and the property of center of gravity constant shift is obtained. A controller that can satisfy asymptotic stability is obtained using a common Lyapunov function for admissible uncertainties resulting from an actuator fault. Simulation results confirm the effectiveness of the proposed method and verify that the walker can provide safe sequential motion when one wheel actuator is at fault.

  6. Novel and deviant Walker A ATP-binding motifs in bacteriophage large terminase-DNA packaging proteins

    International Nuclear Information System (INIS)

    Mitchell, Michael S.; Rao, Venigalla B.

    2004-01-01

    Bacteriophage terminases constitute a very interesting class of viral-coded multifunctional ATPase 'motors' that apparently drive directional translocation of DNA into an empty viral capsid. A common Walker A motif and other conserved signatures of a critical ATPase catalytic center are identified in the N-terminal half of numerous large terminase proteins. However, several terminases, including the well-characterized λ and SPP1 terminases, seem to lack the classic Walker A in the N-terminus. Using sequence alignment approaches, we discovered the presence of deviant Walker A motifs in these and many other phage terminases. One deviation, the presence of a lysine at the beginning of P-loop, may represent a 3D equivalent of the universally conserved lysine in the Walker A GKT/S signature. This and other novel putative Walker A motifs that first came to light through this study help define the ATPase centers of phage and viral terminases as well as elicit important insights into the molecular functioning of this fundamental motif in biological systems

  7. MECHANICAL EFFICIENCY OF A CHAMPION WALKER* • • • • .o •

    African Journals Online (AJOL)

    Oxygen consumplions were measured on a champion walker, while walking at between 6·4 and 16·9 km / hand while running at between lJ·] and 17-7 km/h. Above. 9-7 km / h the curve of oxygen consumption against speed for walking was almost twice as steep as that for rlInning, indicating that el'en champion walkers are ...

  8. Quantum Tunneling and Chaos in Classical Scale Walkers

    Science.gov (United States)

    Su, Jenny; Dijksman, Joshua; Ward, Jeremy; Behringer, Robert

    2014-03-01

    We study the behavior of `walkers' small droplets bouncing on a fluid layer vibrated at amplitudes just below the onset of Faraday instability. It was shown recently that despite their macroscopic size, the droplet dynamics are stochastic in nature and reminiscent of the dual particle-wave dynamics in the realm of quantum mechanics (Couder PRL 2006). We use these walkers to study how chaos, which is macroscopically unpredictable, will manifest in a quantum setting. Pecora showed in 2011 that tunneling for particles that have a chaotic ground state is different from tunneling for particles with a regular ground state (PRE 2011). In the experiment we gather data that illustrates the particle trajectory and tunneling behavior as particles transition across the barrier in the double well system with both integrable and chaotic shapes.

  9. Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma

    Science.gov (United States)

    Huang, Gloria S.; Chiu, Lydia G.; Gebb, Juliana S.; Gunter, Marc J.; Sukumvanich, Paniti; Goldberg, Gary L.; Einstein, Mark H.

    2009-01-01

    Objective The purpose of this study was to determine the clinical utility of CA125 measurement in patients with uterine carcinosarcoma (CS). Methods Ninety-five consecutive patients treated for CS at a single institution were identified. All 54 patients who underwent preoperative CA125 measurement were included in the study. Data were abstracted from the medical records. Tests of association between preoperative CA125 and previously identified clinicopathologic prognostic factors were performed using Fisher’s exact test and Pearson chi-square test. To evaluate relationship of CA125 elevation and survival, a Cox proportional hazard model was used for multivariate analysis, incorporating all of prognostic factors identified by univariate analysis. Results Preoperative CA125 was significantly associated with the presence of extrauterine disease (P<0.001), deep myometrial invasion (P<0.001), and serous histology of the epithelial component (P=0.005). Using univariate survival analysis, stage (HR=1.808, P=0.004), postoperative CA125 level (HR=9.855, P<0.001), and estrogen receptor positivity (HR=0.314, P=0.029) were significantly associated with survival. In the multivariate model, only postoperative CA125 level remained significantly associated with poor survival (HR=5.725, P=0.009). Conclusion Preoperative CA125 elevation is a marker of extrauterine disease and deep myometrial invasion in patients with uterine CS. Postoperative CA125 elevation is an independent prognostic factor for poor survival. These findings indicate that CA125 may be a clinically useful serum marker in the management of patients with CS. PMID:17935762

  10. A Motion Control of a Robotic Walker for Continuous Assistance during Standing, Walking and Seating Operation

    OpenAIRE

    Chugo, Daisuke; Takase, Kunikatsu

    2010-01-01

    In this paper, we develop an active walker system for standing, walking and seating operation continuously which cooperates the developed standing assistance system with safety and stability. For realizing these conditions, our walker coordinates the assisting position cooperating the standing assistance manipulator according to the posture of the patient. Furthermore, our walker adjusts a seating position when the patient sit down which has high risk for falling down. Using our proposed syst...

  11. [Upper extremity kinetics and energy expenditure during walker-assisted gait in children with cerebral palsy].

    Science.gov (United States)

    Konop, Katherine A; Strifling, Kelly M B; Wang, Mei; Cao, Kevin; Eastwood, Daniel; Jackson, Scott; Ackman, Jeffrey; Altiok, Haluk; Schwab, Jeffrey; Harris, Gerald F

    2009-01-01

    We evaluated the relationships between upper extremity (UE) kinetics and the energy expenditure index during anterior and posterior walker-assisted gait in children with spastic diplegic cerebral palsy (CP). Ten children (3 boys, 7 girls; mean age 12.1 years; range 8 to 18 years) with spastic diplegic CP, who ambulated with a walker underwent gait analyses that included UE kinematics and kinetics. Upper extremity kinetics were obtained using instrumented walker handles. Energy expenditure index was obtained using the heart rate method (EEIHR) by subtracting resting heart rate from walking heart rate, and dividing by the walking speed. Correlations were sought between the kinetic variables and the EEIHR and temporal and stride parameters. In general, anterior walker use was associated with a higher EEIHR. Several kinetic variables correlated well with temporal and stride parameters, as well as the EEIHR. All of the significant correlations (r>0.80; pwalker use and involved joint reaction forces (JRF) rather than moments. Some variables showed multiple strong correlations during anterior walker use, including the medial JRF in the wrist, the posterior JRF in the elbow, and the inferior and superior JRFs in the shoulder. The observed correlations may indicate a relationship between the force used to advance the body forward within the walker frame and an increased EEIHR. More work is needed to refine the correlations, and to explore relationships with other variables, including the joint kinematics.

  12. Hydrologic data for the Walker River Basin, Nevada and California, water years 2010–14

    Science.gov (United States)

    Pavelko, Michael T.; Orozco, Erin L.

    2015-12-10

    Walker Lake is a threatened and federally protected desert terminal lake in western Nevada. To help protect the desert terminal lake and the surrounding watershed, the Bureau of Reclamation and U.S. Geological Survey have been studying the hydrology of the Walker River Basin in Nevada and California since 2004. Hydrologic data collected for this study during water years 2010 through 2014 included groundwater levels, surface-water discharge, water chemistry, and meteorological data. Groundwater levels were measured in wells, and surface-water discharge was measured in streams, canals, and ditches. Water samples for chemical analyses were collected from wells, streams, springs, and Walker Lake. Chemical analyses included determining physical properties; the concentrations of major ions, nutrients, trace metals, dissolved gases, and radionuclides; and ratios of the stable isotopes of hydrogen and oxygen. Walker Lake water properties and meteorological parameters were monitored from a floating platform on the lake. Data collection methods followed established U.S. Geological Survey guidelines, and all data are stored in the National Water Information System database. All of the data are presented in this report and accessible on the internet, except multiple-depth Walker Lake water-chemistry data, which are available only in this report.

  13. Test pilots 1962 - Armstrong, Walker, Dana, Peterson, McKay, Thompson, Butchart

    Science.gov (United States)

    1962-01-01

    The research pilots at what in 1962 was called the Flight Research Center standing in front of the X-1E. They are (left to right) Neil Armstrong, Joe Walker, Bill Dana, Bruce Peterson, Jack McKay, Milt Thompson, and Stan Butchart. of the group, Armstrong, Walker, Dana, McKay and Thompson all flew the X-15. Bruce Peterson flew the M2-F2 and HL-10 lifting bodies, while Stan Butchart was the B-29 drop plane pilot for many of the D-558-II and X-1 series research aircraft.

  14. Cloning, purification and crystallization of a Walker-type Pyrococcus abyssi ATPase family member

    International Nuclear Information System (INIS)

    Uhring, Muriel; Bey, Gilbert; Lecompte, Odile; Cavarelli, Jean; Moras, Dino; Poch, Olivier

    2005-01-01

    The Walker-type ATPase PABY2304 of P. abyssi has been cloned, overexpressed, purified and crystallized. X-ray diffraction data from selenomethionine-derivative crystals have been collected to 2.6 Å. The structure has been solved by MAD techniques. Several ATPase proteins play essential roles in the initiation of chromosomal DNA replication in archaea. Walker-type ATPases are defined by their conserved Walker A and B motifs, which are associated with nucleotide binding and ATP hydrolysis. A family of 28 ATPase proteins with non-canonical Walker A sequences has been identified by a bioinformatics study of comparative genomics in Pyrococcus genomes. A high-throughput structural study on P. abyssi has been started in order to establish the structure of these proteins. 16 genes have been cloned and characterized. Six out of the seven soluble constructs were purified in Escherichia coli and one of them, PABY2304, has been crystallized. X-ray diffraction data were collected from selenomethionine-derivative crystals using synchrotron radiation. The crystals belong to the orthorhombic space group C2, with unit-cell parameters a = 79.41, b = 48.63, c = 108.77 Å, and diffract to beyond 2.6 Å resolution

  15. Cloning, purification and crystallization of a Walker-type Pyrococcus abyssi ATPase family member

    Energy Technology Data Exchange (ETDEWEB)

    Uhring, Muriel; Bey, Gilbert; Lecompte, Odile; Cavarelli, Jean; Moras, Dino; Poch, Olivier, E-mail: poch@igbmc.u-strasbg.fr [Département de Biologie et Génomiques Structurales, UMR 7104, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP Strasbourg, 1 Rue Laurent Fries, 64404 Illkirch (France)

    2005-10-01

    The Walker-type ATPase PABY2304 of P. abyssi has been cloned, overexpressed, purified and crystallized. X-ray diffraction data from selenomethionine-derivative crystals have been collected to 2.6 Å. The structure has been solved by MAD techniques. Several ATPase proteins play essential roles in the initiation of chromosomal DNA replication in archaea. Walker-type ATPases are defined by their conserved Walker A and B motifs, which are associated with nucleotide binding and ATP hydrolysis. A family of 28 ATPase proteins with non-canonical Walker A sequences has been identified by a bioinformatics study of comparative genomics in Pyrococcus genomes. A high-throughput structural study on P. abyssi has been started in order to establish the structure of these proteins. 16 genes have been cloned and characterized. Six out of the seven soluble constructs were purified in Escherichia coli and one of them, PABY2304, has been crystallized. X-ray diffraction data were collected from selenomethionine-derivative crystals using synchrotron radiation. The crystals belong to the orthorhombic space group C2, with unit-cell parameters a = 79.41, b = 48.63, c = 108.77 Å, and diffract to beyond 2.6 Å resolution.

  16. The value of double balloon enteroscopy in diagnosing blue rubber bleb naevus syndrome: a case report.

    LENUS (Irish Health Repository)

    O'Kelly, Fardod

    2010-01-01

    Blue rubber bleb naevus syndrome is a rare vascular disorder associated with multiple gastrointestinal haemangiomas that have the potential for life-threatening haemorrhage. These may be difficult to diagnose, and have classically been described using computed tomographic studies and\\/or mesenteric angiography. Resected surgical specimens of these lesions, especially in the small bowel, have often been extensive and poorly localized. The recent advent and progressive development of double balloon enteroscopy has allowed the direct visualization and marking of these enteric lesions and serves as a valuable adjunct not only in diagnosis but also planning prior to surgery to allow accurate estimate of the extent of resection.

  17. Race walking gait and its influence on race walking economy in world-class race walkers.

    Science.gov (United States)

    Gomez-Ezeiza, Josu; Torres-Unda, Jon; Tam, Nicholas; Irazusta, Jon; Granados, Cristina; Santos-Concejero, Jordan

    2018-03-06

    The aim of this study was to determine the relationships between biomechanical parameters of the gait cycle and race walking economy in world-class Olympic race walkers. Twenty-One world-class race walkers possessing the Olympic qualifying standard participated in this study. Participants completed an incremental race walking test starting at 10 km·h -1 , where race walking economy (ml·kg -1 ·km -1 ) and spatiotemporal gait variables were analysed at different speeds. 20-km race walking performance was related to race walking economy, being the fastest race walkers those displaying reduced oxygen cost at a given speed (R = 0.760, p < 0.001). Longer ground contact times, shorter flight times, longer midstance sub-phase and shorter propulsive sub-phase during stance were related to a better race walking economy (moderate effect, p < 0.05). According to the results of this study, the fastest race walkers were more economi cal than the lesser performers. Similarly, shorter flight times are associated with a more efficient race walking economy. Coaches and race walkers should avoid modifying their race walking style by increasing flight times, as it may not only impair economy, but also lead to disqualification.

  18. Circular orbits in cosmic string and Schwarzschild-AdS spacetime with Fermi-Walker transport

    International Nuclear Information System (INIS)

    Bakke, K.; Furtado, C.; Carvalho, A.M. de

    2009-01-01

    In this paper we discuss the Fermi-Walker transport of vectors along orbits in cosmic string and Schwarzschild-AdS spacetimes. We analyze the influence of acceleration on these holonomies. An effect similar to Thomas precession is observed within the process of Fermi-Walker transport along these circular orbits which are studied in the limit of vanishing cosmological constant in Schwarzschild-AdS case; also we obtain Fermi-Walker transport in a Schwarzschild background. In the case of a Schwarzschild spacetime, we analyze the quantized band holonomy invariance. In the limit of zero acceleration we recover the well-known results for holonomy matrix obtained by parallel transport in all these spacetimes. (orig.)

  19. Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component

    Science.gov (United States)

    Cuadra-Urteaga, José Luis; Font, Albert; Tapia, Gustavo; Areal, Juan; Taron, Miquel

    2016-01-01

    ABSTRACT Carcinosarcomas (CS) are biphasic tumors with malignant epithelial and mesenchymal elements. The sarcomatoid elements of CS can include chondrosarcoma, malignant fibrous histiocytoma, osteosarcoma, leiomyosarcoma, fibrosarcoma, or liposarcoma. CS of the upper urinary tract are extremely rare but are associated with a poor prognosis. We report a case of a 44-year-old man with a localized right renal pelvis mass treated with a right nephroureterectomy. The pathological examination showed a high-grade urothelial carcinoma of the renal pelvis, stage III (pT3aNxM0). A few days later, he developed lower back pain, hematuria, cough with hemoptoic sputum and progressive dyspnea. Radiological explorations showed multiple bilateral lung nodules and a retroperitoneal mass. A CT-guided biopsy of the retroperitoneal mass revealed a high-grade angiosarcoma. A review of the nephrectomy specimen showed a microscopic focus of angiosarcoma in the urothelial carcinoma. Therefore, the initial diagnosis was changed to CS of the renal pelvis with an angiosarcoma component. The patient developed progressive respiratory failure and died 8 weeks after surgery. An autopsy revealed a large retroperitoneal mass with metastatic nodules to the abdominal wall, diaphragm, small intestine, liver, spleen, and lung. All lesions were angiosarcoma, with no evidence of urothelial carcinoma. This is the first case reported of a patient with CS of the upper urinary tract with an angiosarcoma component with a very aggressive course that caused the immediate appearance of multiple angiosarcoma metastases. We also describe the clinical and molecular characteristics of CS, which will help to contribute to a better understanding of this type of tumor. PMID:26891233

  20. Revisión con agujas y uso de mitomicina C en bulas de filtración encapsuladas Needle revision and use of Mitomycin-C to manage encapsulated filtering blebs

    Directory of Open Access Journals (Sweden)

    Francisco Fumero González

    2012-01-01

    Full Text Available La trabeculectomía es uno de los tratamientos de elección en los pacientes con glaucoma. La causa más común de fallo de esta cirugía en su primer trimestre es la bula de filtración encapsulada. Usualmente es resultado de la proliferación fibrótica subconjuntival que lleva a fallo de la bula, como por ejemplo en los glaucomas traumáticos. La revisión con agujas y la mitomicina C constituyen una opción efectiva y relativamente segura para restaurar la función de la cirugía de filtración. Se presenta un paciente donde se restableció el flujo de humor acuso con este proceder.Trabeculectomy is the surgical treatment of choice for many patients with glaucoma. The most common cause of failure during the first trimester after trabeculectomy is encapsulated bleb. Generally, that results from scarring in the subconjunctival space with a resultant intrableb fibrosis and the development of a failed bleb, for example in traumatic glaucoma. Needling bleb revision with mitomycin-C appears to be an effective and relatively safe way to revive the function of the filtration surgery. This was the case report of a patient whose aqueous humor flow was reestablished with this treatment.

  1. Extraction of user's navigation commands from upper body force interaction in walker assisted gait.

    Science.gov (United States)

    Frizera Neto, Anselmo; Gallego, Juan A; Rocon, Eduardo; Pons, José L; Ceres, Ramón

    2010-08-05

    The advances in technology make possible the incorporation of sensors and actuators in rollators, building safer robots and extending the use of walkers to a more diverse population. This paper presents a new method for the extraction of navigation related components from upper-body force interaction data in walker assisted gait. A filtering architecture is designed to cancel: (i) the high-frequency noise caused by vibrations on the walker's structure due to irregularities on the terrain or walker's wheels and (ii) the cadence related force components caused by user's trunk oscillations during gait. As a result, a third component related to user's navigation commands is distinguished. For the cancelation of high-frequency noise, a Benedict-Bordner g-h filter was designed presenting very low values for Kinematic Tracking Error ((2.035 +/- 0.358).10(-2) kgf) and delay ((1.897 +/- 0.3697).10(1)ms). A Fourier Linear Combiner filtering architecture was implemented for the adaptive attenuation of about 80% of the cadence related components' energy from force data. This was done without compromising the information contained in the frequencies close to such notch filters. The presented methodology offers an effective cancelation of the undesired components from force data, allowing the system to extract in real-time voluntary user's navigation commands. Based on this real-time identification of voluntary user's commands, a classical approach to the control architecture of the robotic walker is being developed, in order to obtain stable and safe user assisted locomotion.

  2. Philip Glass, Scott Walker ja Sigur Ros! / Immo Mihkelson

    Index Scriptorium Estoniae

    Mihkelson, Immo, 1959-

    2007-01-01

    Pimedate Ööde 11. filmifestivali muusikafilme - Austraalia "Glass: Philipi portree 12 osas" (rež. Scott Hicks), Islandi "Sigur Ros kodus" (rež. Dean DeBois), Suurbritannia "Scott Walker: 30 Century Man" (rež. Stephen Kijak)

  3. Quantum centipedes: collective dynamics of interacting quantum walkers

    International Nuclear Information System (INIS)

    Krapivsky, P L; Luck, J M; Mallick, K

    2016-01-01

    We consider the quantum centipede made of N fermionic quantum walkers on the one-dimensional lattice interacting by means of the simplest of all hard-bound constraints: the distance between two consecutive fermions is either one or two lattice spacings. This composite quantum walker spreads ballistically, just as the simple quantum walk. However, because of the interactions between the internal degrees of freedom, the distribution of its center-of-mass velocity displays numerous ballistic fronts in the long-time limit, corresponding to singularities in the empirical velocity distribution. The spectrum of the centipede and the corresponding group velocities are analyzed by direct means for the first few values of N . Some analytical results are obtained for arbitrary N by exploiting an exact mapping of the problem onto a free-fermion system. We thus derive the maximal velocity describing the ballistic spreading of the two extremal fronts of the centipede wavefunction, including its non-trivial value in the large- N limit. (paper)

  4. Galilean generalized Robertson-Walker spacetimes: A new family of Galilean geometrical models

    Science.gov (United States)

    de la Fuente, Daniel; Rubio, Rafael M.

    2018-02-01

    We introduce a new family of Galilean spacetimes, the Galilean generalized Robertson-Walker spacetimes. This new family is relevant in the context of a generalized Newton-Cartan theory. We study its geometrical structure and analyse the completeness of its inextensible free falling observers. This sort of spacetimes constitutes the local geometric model of a much wider family of spacetimes admitting certain conformal symmetry. Moreover, we find some sufficient geometric conditions which guarantee a global splitting of a Galilean spacetime as a Galilean generalized Robertson-Walker spacetime.

  5. 75 FR 24753 - The Walker Auto Group, Inc., Miamisburg, OH; Notice of Negative Determination Regarding...

    Science.gov (United States)

    2010-05-05

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,471] The Walker Auto Group... Auto Group, Inc., Miamisburg, Ohio, was based on the finding that the subject firm did not shift abroad... of the subject firm should be eligible for TAA because the Walker Auto Group, Inc., Miamisburg, Ohio...

  6. Walker use, but not falls, is associated with lower physical functioning and health of residents in an assisted-living environment.

    Science.gov (United States)

    Andersen, Daniel A; Roos, Bernard A; Stanziano, Damian C; Gonzalez, Natasha M; Signorile, Joseph F

    2007-01-01

    The relationship between perceived health and walker use has seldom been addressed. Concerns over falls and falls risk are precursors to walker use. We compared the SF-36 scores of 26 women and 14 men, mean age 86.8 +/- 6.0 years based on walker use and faller status. An analysis of covariance (ANCOVA) with age as the covariate, compared groups for the SF-36 constructs and totals score. Significant differences were noted between walker users and nonusers in physical functioning, role limitations due to physical problems, general health, and the total SF-36 score. Pairwise comparisons favored nonusers, while no differences were seen due to faller status. Walker use is associated with lower self-perceptions of physical functioning, role limitations due to physical problems, and general health in assisted-living residents. Faller status is not associated with self-perceived health status. Although walker use aids mobility and lowers the probability of falls, further research is needed to determine if the prescription of assistive devices has a more negative impact on self-perceived health than does falling. This possibility could be explained, in part, by the greater activity levels of those individuals who do not depend on walkers.

  7. Differences in the Limits of Stability Between Older Rolling Walker Users and Older Single-Tip-Cane Users - A Preliminary Study.

    Science.gov (United States)

    Liu, Hao Howe; Quiben, Myles; Holmes, Clayton; Connors, Michael; Salem, Yasser

    To identify the differences in the limits of stability (LOS) between older rolling walker and single-tip-cane users. This was a matched paired t-test design with repeated measure. Eighteen older subjects were matched based on age, gender, and functional level. The subjects were assessed using the multidirectional reach test initially and 5-month later in four directions: forward, backward, leftward, and rightward. Initially, there were no differences between cane users and rolling walker users in the LOS in all directions. However, 5-month later, the cane users who held their canes in their right hand had significantly better stability in forward and rightward reach than the walker users (p walker users demonstrated significantly decreased functional reach in forward reach (p walker users in the forward direction and in the direction toward the side holding the cane. This study may provide guide for clinicians including nurses for selecting appropriate rehabilitative interventions for older adults using walkers and canes.

  8. Dandy-Walker malformation | Hamid | Egyptian Journal of Medical ...

    African Journals Online (AJOL)

    Dandy-Walker malformation is a rare congenital malformation and involves the cerebellum and fourth ventricle. The condition is characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilatation of the fourth ventricle, and enlargement of the posterior fossa. A large number of concomitant problems may be ...

  9. Radiosensitivity of the DS-carcinosarcoma of the rat as influenced by immune reactions

    International Nuclear Information System (INIS)

    Rotte, K.

    1972-01-01

    BDII rats obtained humoral antibodies in a xenogenetic or syngenetic immune serum or specific sensitised isogenetic immune cells for passive immunisation. Other animals were actively immunised with a so-called large dose of DS-carcinosarcoma extract or a so-called small dose of the tumour extract. The mode of irradiation was chosen in such a manner that even slight differences in the radiation sensitivity between immunised and non-immunised animals would as far as possible not be hidden by other factors. Thus when irradiating the tumours, one did without the administration of a dose which would have effected a best possible irradiation effect. A greater fractionation of the uniformly administered total dose of 2,000 R in the tests was also avoided. If the growth of a tumour can be inhibited by an immunologic influence of the tumour host relationship, then the radiation sensitivity of these cells is sumultaneously increased. If the specifically prepared immunity against tumours was not transfered to the test animals, no influence on the radiation sensitivity of the tumours was found. If the growth of the tumour accelerates, then a reduced radiation sensitivity of these tumours was simulated by the fast growth partly compensating the irradiation effect. A transfer of animal experimental investigations to the treatment of human cancer is still faced by great difficulties. The experience gathered in the last decades in the field of experimental tumour immunology are, however, important steps to this target. (orig./LH) [de

  10. Deterministic and Probabilistic Serviceability Assessment of Footbridge Vibrations due to a Single Walker Crossing

    Directory of Open Access Journals (Sweden)

    Cristoforo Demartino

    2018-01-01

    Full Text Available This paper presents a numerical study on the deterministic and probabilistic serviceability assessment of footbridge vibrations due to a single walker crossing. The dynamic response of the footbridge is analyzed by means of modal analysis, considering only the first lateral and vertical modes. Single span footbridges with uniform mass distribution are considered, with different values of the span length, natural frequencies, mass, and structural damping and with different support conditions. The load induced by a single walker crossing the footbridge is modeled as a moving sinusoidal force either in the lateral or in the vertical direction. The variability of the characteristics of the load induced by walkers is modeled using probability distributions taken from the literature defining a Standard Population of walkers. Deterministic and probabilistic approaches were adopted to assess the peak response. Based on the results of the simulations, deterministic and probabilistic vibration serviceability assessment methods are proposed, not requiring numerical analyses. Finally, an example of the application of the proposed method to a truss steel footbridge is presented. The results highlight the advantages of the probabilistic procedure in terms of reliability quantification.

  11. Variability in energy cost and walking gait during race walking in competitive race walkers.

    Science.gov (United States)

    Brisswalter, J; Fougeron, B; Legros, P

    1998-09-01

    The aim of this study was to examine the variability of energy cost (Cw) and race walking gait after a 3-h walk at the competition pace in race walkers of the same performance level. Nine competitive race walkers were studied. In the same week, after a first test of VO2max determination, each subject completed two submaximal treadmill walks (6 min length, 0% grade, 12 km X h(-1) speed) before and after a 3-h overground test completed at the individual competition speed of the race walker. During the two submaximal tests, subjects were filmed between the 2nd and the 4th min, and physiological parameters were recorded between the 4th and the 6th min. Results showed two trends. On the one hand, we observed a significant and systematic increase in energy cost of walking (mean deltaCw = 8.4%), whereas no variation in the gait kinematics prescribed by the rules of race walking was recorded. On the other hand, this increase in metabolic energy demand was accompanied by variations of different magnitude and direction of stride length, of the excursion of the heel and of the maximal ankle flexion at toe-off among the race walkers. These results indicated that competitive race walkers are able to maintain their walking gait with exercise duration apart from a systematic increase in energy cost. Moreover, in this form of locomotion the effect of fatigue on the gait variability seems to be an individual function of the race walk constraints and the constraints of the performer.

  12. Ground reaction force and 3D biomechanical characteristics of walking in short-leg walkers.

    Science.gov (United States)

    Zhang, Songning; Clowers, Kurt G; Powell, Douglas

    2006-12-01

    Short-leg walking boots offer several advantages over traditional casts. However, their effects on ground reaction forces (GRF) and three-dimensional (3D) biomechanics are not fully understood. The purpose of the study was to examine 3D lower extremity kinematics and joint dynamics during walking in two different short-leg walking boots. Eleven (five females and six males) healthy subjects performed five level walking trials in each of three conditions: two testing boot conditions, Gait Walker (DeRoyal Industries, Inc.) and Equalizer (Royce Medical Co.), and one pair of laboratory shoes (Noveto, Adidas). A force platform and a 6-camera Vicon motion analysis system were used to collect GRFs and 3D kinematic data during the testing session. A one-way repeated measures analysis of variance (ANOVA) was used to evaluate selected kinematic, GRF, and joint kinetic variables (p<0.05). The results revealed that both short-leg walking boots were effective in minimizing ankle eversion and hip adduction. Neither walker increased the bimodal vertical GRF peaks typically observed in normal walking. However, they did impose a small initial peak (<1BW) earlier in the stance phase. The Gait Walker also exhibited a slightly increased vertical GRF during midstance. These characteristics may be related to the sole materials/design, the restriction of ankle movements, and/or the elevated heel heights of the tested walkers. Both walkers appeared to increase the demand on the knee extensors while they decreased the demand of the knee and hip abductors based on the joint kinetic results.

  13. Extraction of user's navigation commands from upper body force interaction in walker assisted gait

    Directory of Open Access Journals (Sweden)

    Pons José L

    2010-08-01

    Full Text Available Abstract Background The advances in technology make possible the incorporation of sensors and actuators in rollators, building safer robots and extending the use of walkers to a more diverse population. This paper presents a new method for the extraction of navigation related components from upper-body force interaction data in walker assisted gait. A filtering architecture is designed to cancel: (i the high-frequency noise caused by vibrations on the walker's structure due to irregularities on the terrain or walker's wheels and (ii the cadence related force components caused by user's trunk oscillations during gait. As a result, a third component related to user's navigation commands is distinguished. Results For the cancelation of high-frequency noise, a Benedict-Bordner g-h filter was designed presenting very low values for Kinematic Tracking Error ((2.035 ± 0.358·10-2 kgf and delay ((1.897 ± 0.3697·101ms. A Fourier Linear Combiner filtering architecture was implemented for the adaptive attenuation of about 80% of the cadence related components' energy from force data. This was done without compromising the information contained in the frequencies close to such notch filters. Conclusions The presented methodology offers an effective cancelation of the undesired components from force data, allowing the system to extract in real-time voluntary user's navigation commands. Based on this real-time identification of voluntary user's commands, a classical approach to the control architecture of the robotic walker is being developed, in order to obtain stable and safe user assisted locomotion.

  14. Sirolimus alternative to blood transfusion as a life saver in blue rubber bleb nevus syndrome: A case report.

    Science.gov (United States)

    Wang, Ke-Ling; Ma, Shu-Fang; Pang, Ling-Yu; Zhang, Meng-Na; Hu, Lin-Yan; Liu, Meng-Jia; Zou, Li-Ping

    2018-02-01

    Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations. The gastrointestinal bleeding and secondary iron deficiency anemia are the most common complications. There are currently no effective treatments for BRBNS. Here, we report a case of successful treatment with a small dose of sirolimus of a BRBN patient with a de novo gene mutation. A 12-year-old female was admitted to our hospital with multiple hemangiomas for 12 years. The patient often displayed melena; she recently received transfusion of 2 units of red blood cells once every 2 weeks. Multiple fist-sized hemangiomas were piled up on both sides and back of the neck, and were also noted on the arms, legs, chest, back, and on the tip of the tongue. The laboratory findings demonstrated severe anemia. Blood sample sequencing detected a heterozygous de novo mutation c.2545C > Tin the TEK gene. Based on these findings, final diagnosis of Blue rubber bleb nevus syndrome (BRBNS) was made. After the diagnosis, low-dose sirolimus was orally administered. The patient's hemoglobin was increased after treatment with sirolimus for 1 month. Since the initial treatment with sirolimus, she had not received any blood transfusions. The skin and mucosal hemangioma decreased significantly, and new digestive tract hemorrhage, muscle hematoma, or adverse drug reactions were not observed. we report a case of a mutation in exon 15 of the TEK gene leading to BRBN. It was successfully treated with a small dose of sirolimus as an alternative to blood transfusion in order to save the of BRBN patient's life.

  15. Where Are They Now: Nathalie Walker Moves from Science to Activism and Art Communications | Poster

    Science.gov (United States)

    Whether it’s in a flowerbed or an art gallery, former Werner H. Kirsten (WHK) student intern Nathalie Walker can’t help but to cause a buzz. Since completing her WHK internship in the summer of 2015, Walker has been attending Loyola University Maryland, where she is striving to make a positive impact on campus.

  16. Quantization of Robertson-Walker geometry coupled to fermionic matter

    International Nuclear Information System (INIS)

    Christodoulakis, T.; Zanelli, J.

    1983-06-01

    A Robertson-Walker universe coupled to a spin 1/2 Dirac field is quantized following Dirac's formalism for constrained Hamiltonian systems. It is found that in nearly all cases it can be asserted that the universe avoids the collapse. (author)

  17. Exact solution of two interacting run-and-tumble random walkers with finite tumble duration

    International Nuclear Information System (INIS)

    Slowman, A B; Evans, M R; Blythe, R A

    2017-01-01

    We study a model of interacting run-and-tumble random walkers operating under mutual hardcore exclusion on a one-dimensional lattice with periodic boundary conditions. We incorporate a finite, poisson-distributed, tumble duration so that a particle remains stationary whilst tumbling, thus generalising the persistent random walker model. We present the exact solution for the nonequilibrium stationary state of this system in the case of two random walkers. We find this to be characterised by two lengthscales, one arising from the jamming of approaching particles, and the other from one particle moving when the other is tumbling. The first of these lengthscales vanishes in a scaling limit where the continuous-space dynamics is recovered whilst the second remains finite. Thus the nonequilibrium stationary state reveals a rich structure of attractive, jammed and extended pieces. (paper)

  18. Motor properties from persistence: a linear molecular walker lacking spatial and temporal asymmetry

    International Nuclear Information System (INIS)

    Zuckermann, Martin J; Forde, Nancy R; Angstmann, Christopher N; Schmitt, Regina; Linke, Heiner; Blab, Gerhard A; Bromley, Elizabeth HC; Curmi, Paul MG

    2015-01-01

    The stepping direction of linear molecular motors is usually defined by a spatial asymmetry of the motor, its track, or both. Here we present a model for a molecular walker that undergoes biased directional motion along a symmetric track in the presence of a temporally symmetric chemical cycle. Instead of using asymmetry, directionality is achieved by persistence. At small load force the walker can take on average thousands of steps in a given direction until it stochastically reverses direction. We discuss a specific experimental implementation of a synthetic motor based on this design and find, using Langevin and Monte Carlo simulations, that a realistic walker can work against load forces on the order of picoNewtons with an efficiency of ∼18%, comparable to that of kinesin. In principle, the walker can be turned into a permanent motor by externally monitoring the walker’s momentary direction of motion, and using feedback to adjust the direction of a load force. We calculate the thermodynamic cost of using feedback to enhance motor performance in terms of the Shannon entropy, and find that it reduces the efficiency of a realistic motor only marginally. We discuss the implications for natural protein motor performance in the context of the strong performance of this design based only on a thermal ratchet. (paper)

  19. Unintentional fall injuries associated with walkers and canes in older adults treated in U.S. emergency departments.

    Science.gov (United States)

    Stevens, Judy A; Thomas, Karen; Teh, Leesia; Greenspan, Arlene I

    2009-08-01

    To characterize nonfatal, unintentional, fall-related injuries associated with walkers and canes in older adults. Surveillance data of injuries treated in hospital emergency departments (EDs), January 1, 2001, to December 31, 2006. The National Electronic Injury Surveillance System All Injury Program, which collects data from a nationally representative stratified probability sample of 66 U.S. hospital EDs. People aged 65 and older treated in EDs for 3,932 nonfatal unintentional fall injuries and whose records indicated that a cane or a walker was involved in the fall. Sex, age, whether the fall involved a cane or walker, primary diagnosis, part of the body injured, disposition, and location and circumstances of the fall. An estimated 47,312 older adult fall injuries associated with walking aids were treated annually in U.S. EDs: 87.3% with walkers, 12.3% with canes, and 0.4% with both. Walkers were associated with seven times as many injuries as canes. Women's injury rates exceeded those for men (rate ratios=2.6 for walkers, 1.4 for canes.) The most prevalent injuries were fractures and contusions or abrasions. Approximately one-third of subjects were hospitalized for their injuries. Injuries and hospital admissions for falls associated with walking aids were frequent in this highly vulnerable population. The results suggest that more research is needed to improve the design of walking aids. More information also is needed about the circumstances preceding falls, both to better understand the contributing fall risk factors and to develop specific and effective fall prevention strategies.

  20. Walker-type velocity oscillations of magnetic domain walls

    International Nuclear Information System (INIS)

    Vella-Coleiro, G.P.

    1976-01-01

    We report stroboscopic observations of the radial motion of a magnetic bubble domain wall in an epitaxial LuGdAl iron garnet film. At high drive fields, initial velocities up to 9500 cm/sec were measured, and the domain wall was observed to move backwards during the field pulse, in agreement with calculations based on the Walker model

  1. Finding the Right Formula: Edwin H. Walker Jr

    Science.gov (United States)

    Keels, Crystal L.

    2005-01-01

    Edwin H. Walker Jr earned his doctorate in chemistry at age 27 and has barely looked back. With 13 publications under his belt before coming out of graduate school, he has also given more than 20 poster presentations in national venues, most recently at the American Chemical Society. He can also include securing a half-million-dollar National…

  2. 77 FR 67811 - Porter-Walker LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

    Science.gov (United States)

    2012-11-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-327-000] Porter-Walker LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Porter-Walker...

  3. SYMMETRY AS CONCEPTUAL METAPHOR IN WALKER'S THE COLOR PURPLE

    Directory of Open Access Journals (Sweden)

    Elena Tapia

    2003-05-01

    Full Text Available The author analyzes three types of the conceptual metaphor of embodied symmetry in Alice Walker's novel, The color purple (1982. These metaphorical projections, perceived as equilibrium and its breakage in abstract phenomena, enable readers to reexamine issues of race, non-traditional families, and gender roles. The dis/equilibrium emerges in the novel's epistolary structure. Biological equilibrium breaks in incidents of rape and incest. Walker creates characters in the novel through default-concept opposites of black/white, submissive/dominant, male/female and others. These contraries foreground issues of race and gender. The novel's asymmetries engage readers, leading them to rethink individual character histories and motives. The removal of objects (e.g., rape, mothers deprived of children suggests conceptual asymmetry and alerts readers to parallel themes of sexual and racial oppression. Subjugation sometimes subtle, sometimes blatant- manifests in simple oppositions. In epistemological terms, readers seek causal explanations for the asymmetries of the narrative, interpreting each to recover its history.

  4. Mary Edwards Walker, M.D.: a feminist physician a century ahead of her time.

    Science.gov (United States)

    Spiegel, A D; Suskind, P B

    1996-06-01

    In her teens, Mary Edwards Walker already wore the "bloomer" outfit began to campaign for reforming the "unhygienic" clothing of women. Assertively, she attended medical school and earned her M.D. degree. Due to prejudice, her practice did not flourish and she moved to Washington to offer her medical services to the Union as the Civil War began. Rebuffed by the male medical bureaucrats, she volunteered her services anyway. Eventually, she was awarded the Congressional Medal of Honor, the only women to ever gain such distinction. After the war, Walker became a journalist, an author of two sensational books, a political lobbyist, a suffrage campaigner, a professional and public lecturer, an ardent dress reformer, a peace activist, a Utopianist and a women's right advocate. Light-years ahead of her times, Dr. Walker was an intelligent, independent, irrepressible and indefatigable proponent for a host of worthy causes.

  5. Nursery Pest Management of Phytolyma lata Walker (Scott) Attack ...

    African Journals Online (AJOL)

    The establishment of plantations of Milicia excelsa has been constrained by the gall-forming psyllid Phytolyma lata Walker (Scott) that causes extensive damage to young plants. We present findings of an experiment aimed at preventing Phytolyma attack on Milicia seedlings in the nursery using chemical control and ...

  6. Hidden marker position estimation during sit-to-stand with walker.

    Science.gov (United States)

    Yoon, Sang Ho; Jun, Hong Gul; Dan, Byung Ju; Jo, Byeong Rim; Min, Byung Hoon

    2012-01-01

    Motion capture analysis of sit-to-stand task with assistive device is hard to achieve due to obstruction on reflective makers. Previously developed robotic system, Smart Mobile Walker, is used as an assistive device to perform motion capture analysis in sit-to-stand task. All lower limb markers except hip markers are invisible through whole session. The link-segment and regression method is applied to estimate the marker position during sit-to-stand. Applying a new method, the lost marker positions are restored and the biomechanical evaluation of the sit-to-stand movement with a Smart Mobile Walker could be carried out. The accuracy of the marker position estimation is verified with normal sit-to-stand data from more than 30 clinical trials. Moreover, further research on improving the link segment and regression method is addressed.

  7. Dynamic optimization of walker-assisted FES-activated paraplegic walking: simulation and experimental studies.

    Science.gov (United States)

    Nekoukar, Vahab; Erfanian, Abbas

    2013-11-01

    In this paper, we propose a musculoskeletal model of walker-assisted FES-activated paraplegic walking for the generation of muscle stimulation patterns and characterization of the causal relationships between muscle excitations, multi-joint movement, and handle reaction force (HRF). The model consists of the lower extremities, trunk, hands, and a walker. The simulation of walking is performed using particle swarm optimization to minimize the tracking errors from the desired trajectories for the lower extremity joints, to reduce the stimulations of the muscle groups acting around the hip, knee, and ankle joints, and to minimize the HRF. The results of the simulation studies using data recorded from healthy subjects performing walker-assisted walking indicate that the model-generated muscle stimulation patterns are in agreement with the EMG patterns that have been reported in the literature. The experimental results on two paraplegic subjects demonstrate that the proposed methodology can improve walking performance, reduce HRF, and increase walking speed when compared to the conventional FES-activated paraplegic walking. Copyright © 2013 IPEM. Published by Elsevier Ltd. All rights reserved.

  8. Construction of calibration pads facility, Walker Field, Grand Junction, Colorado

    International Nuclear Information System (INIS)

    Ward, D.L.

    1978-08-01

    A gamma-ray spectrometer facility was completed at Walker Field Airport, Grand Junction, Colorado, in November 1976. This report describes spectrometers and their calibration, the construction of the spectrometer facility, the radioelement concentrations, procedures for using the facilites, and environmental considerations

  9. A gait stability investigation into FES-assisted paraplegic walking based on the walker tipping index.

    Science.gov (United States)

    Ming, Dong; Bai, Yanru; Liu, Xiuyun; Qi, Hongzhi; Cheng, Longlong; Wan, Baikun; Hu, Yong; Wong, Yatwa; Luk, Keith D K; Leong, John C Y

    2009-12-01

    The gait outcome measures used in clinical trials of paraplegic locomotor training determine the effectiveness of improved walking function assisted by the functional electrical stimulation (FES) system. Focused on kinematic, kinetic or physiological changes of paraplegic patients, traditional methods cannot quantify the walking stability or identify the unstable factors of gait in real time. Up until now, the published studies on dynamic gait stability for the effective use of FES have been limited. In this paper, the walker tipping index (WTI) was used to analyze and process gait stability in FES-assisted paraplegic walking. The main instrument was a specialized walker dynamometer system based on a multi-channel strain-gauge bridge network fixed on the frame of the walker. This system collected force information for the handle reaction vector between the patient's upper extremities and the walker during the walking process; the information was then converted into walker tipping index data, which is an evaluation indicator of the patient's walking stability. To demonstrate the potential usefulness of WTI in gait analysis, a preliminary clinical trial was conducted with seven paraplegic patients who were undergoing FES-assisted walking training and seven normal control subjects. The gait stability levels were quantified for these patients under different stimulation patterns and controls under normal walking with knee-immobilization through WTI analysis. The results showed that the walking stability in the FES-assisted paraplegic group was worse than that in the control subject group, with the primary concern being in the anterior-posterior plane. This new technique is practical for distinguishing useful gait information from the viewpoint of stability, and may be further applied in FES-assisted paraplegic walking rehabilitation.

  10. A gait stability investigation into FES-assisted paraplegic walking based on the walker tipping index

    Science.gov (United States)

    Ming, Dong; Bai, Yanru; Liu, Xiuyun; Qi, Hongzhi; Cheng, Longlong; Wan, Baikun; Hu, Yong; Wong, Yatwa; Luk, Keith D. K.; Leong, John C. Y.

    2009-12-01

    The gait outcome measures used in clinical trials of paraplegic locomotor training determine the effectiveness of improved walking function assisted by the functional electrical stimulation (FES) system. Focused on kinematic, kinetic or physiological changes of paraplegic patients, traditional methods cannot quantify the walking stability or identify the unstable factors of gait in real time. Up until now, the published studies on dynamic gait stability for the effective use of FES have been limited. In this paper, the walker tipping index (WTI) was used to analyze and process gait stability in FES-assisted paraplegic walking. The main instrument was a specialized walker dynamometer system based on a multi-channel strain-gauge bridge network fixed on the frame of the walker. This system collected force information for the handle reaction vector between the patient's upper extremities and the walker during the walking process; the information was then converted into walker tipping index data, which is an evaluation indicator of the patient's walking stability. To demonstrate the potential usefulness of WTI in gait analysis, a preliminary clinical trial was conducted with seven paraplegic patients who were undergoing FES-assisted walking training and seven normal control subjects. The gait stability levels were quantified for these patients under different stimulation patterns and controls under normal walking with knee-immobilization through WTI analysis. The results showed that the walking stability in the FES-assisted paraplegic group was worse than that in the control subject group, with the primary concern being in the anterior-posterior plane. This new technique is practical for distinguishing useful gait information from the viewpoint of stability, and may be further applied in FES-assisted paraplegic walking rehabilitation.

  11. Walking on the edge: meanings of living in an ageing body and using a walker in everyday life - a phenomenological hermeneutic study.

    Science.gov (United States)

    Brännström, Helene; Bäckman, Margit; Santamäki Fischer, Regina

    2013-05-01

    In order to maintain one's state of health whilst growing older, the ability to walk is essential. The aim of this study was to illuminate the meanings of the lived experience of living in an ageing body and using a walker in daily life. Narrative interviews were performed with seven older persons aged 79-95 years. The transcribed text was analysed using a phenomenological hermeneutic method. The key finding of the study was that the lived experience of living in an ageing body and using a walker in daily life was interpreted as 'walking on the edge' based on the themes 'Being vulnerable and dependent' and 'Being confident and independent'. The results highlight the importance of reflecting on this phenomenon as a health care professional while meeting the care needs of older persons who use walkers. Nurses need to consider the walker as a personal and valued possession of the individual and handle the walker in agreement with the older person, placing the walker close at hand with the brakes locked to give secure support. © 2012 Blackwell Publishing Ltd.

  12. “Ancestors We Didn’t Even Know We Had”: Alice Walker, Asian Religion, and Ethnic Authenticity

    Directory of Open Access Journals (Sweden)

    Kyle Garton-Gundling

    2015-03-01

    Full Text Available Recent debates about the ethics of identity in a global age have dealt with how to prioritize conflicting local and global allegiances. Guided by these concerns, the fiction of Alice Walker develops a distinctive view of how local cultures and global movements can fruitfully interact. This vision depends on concepts from Asian religions, a major influence that critics of Walker have largely overlooked. Walker promotes Hindu and Buddhist meditation in a context of widespread African American skepticism toward Asian religions. According to widespread notions of cultural authenticity, Asian religions cannot nourish an African American connection to ethnic roots. In response to this challenge, Alice Walker’s fiction portrays Hindu and Buddhist mystics as African Americans’ ancestors, thus positioning these faiths as authentically black. By creatively enfolding Asian religions into her sense of African American heritage, Walker builds a spiritual cosmopolitanism that relies on claims of ancestral affiliation even when these claims are not literal. This strategy is Walker’s effort to create a new paradigm of cultural authenticity, one that allows individuals and groups to choose their ancestors. Walker’s approach seeks to incorporate disparate global influences while still valorizing the figure of the ancestor. This innovative approach places Walker at the forefront of a growing number of African American artists and intellectuals who promote Asian religions to American minorities. Walker’s work vividly dramatizes larger concerns in transnational American Studies: Eastern philosophy’s relevance to identity politics, the tensions between universal ideals and cultural specifics, and the ethics of cross-cultural appropriation.

  13. Pedestrian Dharma: Slowness and Seeing in Tsai Ming-Liang’s Walker

    Directory of Open Access Journals (Sweden)

    Teng-Kuan Ng

    2018-06-01

    Full Text Available This paper studies the ways that Walker, a short film by the Malaysian-Taiwanese auteur Tsai Ming-Liang, visualizes the relationship between Buddhism and modernity. Via detailed film analysis as well as attention to sources in premodern Buddhist traditions, this paper argues that its filmic performance of Zen walking meditation serves two functions: To present slowness and simplicity as prophetic counterpoints against the dizzying excesses of the contemporary metropolis; and to offer contemplative attentiveness as a therapeutic resource for life in the modern world. By instantiating and cultivating critical shifts in viewerly perspective in the manner of Buddhist ritual practice, Walker invites us to envision how a place of frenetic distraction or pedestrian mundaneness might be transfigured into a site of beauty, wonder, and liberation.

  14. Anisotropic evolution of 5D Friedmann-Robertson-Walker spacetime

    International Nuclear Information System (INIS)

    Middleton, Chad A.; Stanley, Ethan

    2011-01-01

    We examine the time evolution of the five-dimensional Einstein field equations subjected to a flat, anisotropic Robertson-Walker metric, where the 3D and higher-dimensional scale factors are allowed to dynamically evolve at different rates. By adopting equations of state relating the 3D and higher-dimensional pressures to the density, we obtain an exact expression relating the higher-dimensional scale factor to a function of the 3D scale factor. This relation allows us to write the Friedmann-Robertson-Walker field equations exclusively in terms of the 3D scale factor, thus yielding a set of 4D effective Friedmann-Robertson-Walker field equations. We examine the effective field equations in the general case and obtain an exact expression relating a function of the 3D scale factor to the time. This expression involves a hypergeometric function and cannot, in general, be inverted to yield an analytical expression for the 3D scale factor as a function of time. When the hypergeometric function is expanded for small and large arguments, we obtain a generalized treatment of the dynamical compactification scenario of Mohammedi [Phys. Rev. D 65, 104018 (2002)] and the 5D vacuum solution of Chodos and Detweiler [Phys. Rev. D 21, 2167 (1980)], respectively. By expanding the hypergeometric function near a branch point, we obtain the perturbative solution for the 3D scale factor in the small time regime. This solution exhibits accelerated expansion, which, remarkably, is independent of the value of the 4D equation of state parameter w. This early-time epoch of accelerated expansion arises naturally out of the anisotropic evolution of 5D spacetime when the pressure in the extra dimension is negative and offers a possible alternative to scalar field inflationary theory.

  15. Ab Interno Trabeculectomy With the Trabectome as a Valuable Therapeutic Option for Failed Filtering Blebs.

    Science.gov (United States)

    Wecker, Thomas; Neuburger, Matthias; Bryniok, Laura; Bruder, Kathrin; Luebke, Jan; Anton, Alexandra; Jordan, Jens F

    2016-09-01

    Uncontrolled intraocular pressure (IOP) after glaucoma filtration surgery is a challenging problem in the management of glaucoma patients. The Trabectome is a device for selective electroablation of the trabecular meshwork through a clear cornea incision without affecting the conjunctiva. Minimally invasive glaucoma surgery using the Trabectome is safe and effective as primary glaucoma surgery. Here we investigate the results of ab interno trabeculectomy with the Trabectome for IOP control in patients with a failed filtering bleb. A total of 60 eyes of 60 consecutive patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PXG) were enrolled in this single center observational study. Trabectome surgery was performed alone or in combination with phacoemulsification by 2 experienced surgeons. IOP readings and number of IOP lowering medication as primary outcome parameters were taken by an independent examiner. Intraoperative and postoperative medication were recorded systematically. Mean IOP before surgery was 24.5±3.5 mm Hg and decreased to 15.7±3.4 (-36%) after mean follow-up of 415 days. The number of necessary IOP lowering medication dropped from 2.1±1.3 to 1.8±1.2 (14% reduction from baseline). A total of 25% (n=15) of cases reported here needed additional surgery after 517 days (range: 6 to 1563 d). No major complications were observed. After mean follow-up, we found a qualified success rate for PXG of 87% and 50% for POAG as revealed by the Kaplan-Meier analysis according to the definitions for success in advanced glaucoma cases according to the World Glaucoma Association (40% reduction from baseline IOP and maximum IOP of 15 mm Hg). Trabectome surgery for uncontrolled IOP after trabeculectomy is safe and effective especially in PXG patients. Given the demanding subgroup of patients studied here, it is not surprising that success rates are lower compared with previous studies investigating the Trabectome for primary glaucoma surgery

  16. Spacelike Hypersurfaces in Weighted Generalized Robertson-Walker Space-Times

    Directory of Open Access Journals (Sweden)

    Ximin Liu

    2018-01-01

    Full Text Available Applying generalized maximum principle and weak maximum principle, we obtain several uniqueness results for spacelike hypersurfaces immersed in a weighted generalized Robertson-Walker (GRW space-time under suitable geometric assumptions. Furthermore, we also study the special case when the ambient space is static and provide some results by using Bochner’s formula.

  17. Can intermittent long-range jumps of a random walker compensate for lethargy?

    International Nuclear Information System (INIS)

    Bologna, Mauro; Ahat, Yasin; Grigolini, Paolo; West, Bruce J

    2011-01-01

    We study the dynamics of a lazy random walker who is inactive for extended times and tries to make up for her laziness with very large jumps. She remains in a condition of rest for a time τ derived from a waiting-time distribution ψ(τ)∝1/τ μ W , with μ W μ ξ , with μ ξ > 1. The most convenient choice to make up for the random walker laziness would be to select μ ξ W > 2 would produce Levy flights with scaling δ = 1/(μ ξ - 1) and consequently super-diffusion. According to the Sparre Andersen theorem, the distribution density of the first times to go from x A to x B > x A has the inverse power law form f(t)∝1/(t μ FPT ) with μ FPT = μ SA = 1.5. We find the surprising result that there exists a region of the phase space (μ ξ , μ W ) with μ W FPT > μ SA and the lazy walker compensates for her laziness. There also exists an extended region breaking the Sparre Andersen theorem, where the lazy runner cannot compensate for her laziness. We make conjectures concerning the possible relevance of this mathematical prediction, supported by numerical calculations, for the problem of animal foraging. (fast track communication)

  18. Experimental Studies of Wheelchair and Walker Users Passing Through Doors with Different Opening Force.

    Science.gov (United States)

    Nersveen, Jonny

    2016-01-01

    Users of walkers and users of different categories of wheelchairs tested doors with different opening force, aiming to reveal the limit that these groups of people could manage on an everyday basis. 94.7% of the wheelchair users reported that a door opening force of 30 N was acceptable, while as 92.1% of this group described 40 N as acceptable. Similarly, 100% of the walker users reported that a door opening force of 30 N was acceptable, while as 87,5% of this group described 40 N as acceptable.

  19. [Characteristics of polyamine biosynthesis regulation and tumor growth rate in hormone-dependant grafted breast tumors of mice and rats].

    Science.gov (United States)

    Orlovskiĭ, A A

    2007-01-01

    Effect of the inhibitors of polyamines biosynthesis on completely or partially hormone-dependant breast tumors (mouse Ca755 carcinoma and Walker W-256 carcinosarcoma) is essentially special: in contrary to hormone-dependant tumors, this effect may be not only breaking but stimulating as well. Change-over from one to another mode of reaction is conditioned, most probable, by hormonal status, which is determined by one or another estral cycle phase. Biochemical mechanisms of this change-over are closely connected with polyamines metabolism, namely the degree of polyamines (especially spermine) interconvertion and physiological reactivity level of the system controlling expression of ornithin-decarboxilase. At that, the first of these pathways is predominant for completely hormone-dependant Ca755 and the second one -for partially hormone-dependant W-256.

  20. Assessment of thermal effects in a model of the human head implanted with a wireless active microvalve for the treatment of glaucoma creating a filtering bleb

    Science.gov (United States)

    Schaumburg, F.; Guarnieri, F. A.

    2017-05-01

    A 3D anatomical computational model is developed to assess thermal effects due to exposure to the electromagnetic field required to power a new investigational active implantable microvalve for the treatment of glaucoma. Such a device, located in the temporal superior eye quadrant, produces a filtering bleb, which is included in the geometry of the model, together with the relevant ocular structures. The electromagnetic field source—a planar coil—as well as the microvalve antenna and casing are also included. Exposure to the electromagnetic field source of an implanted and a non-implanted subject are simulated by solving a magnetic potential formulation, using the finite element method. The maximum SAR10 is reached in the eyebrow and remains within the limits suggested by the IEEE and ICNIRP standards. The anterior chamber, filtering bleb, iris and ciliary body are the ocular structures where more absorption occurs. The temperature rise distribution is also obtained by solving the bioheat equation with the finite element method. The numerical results are compared with the in vivo measurements obtained from four rabbits implanted with the microvalve and exposed to the electromagnetic field source.

  1. Empowering and Assisting Natural Empowering and Assisting Natural Human Mobility: The Simbiosis Walker

    Directory of Open Access Journals (Sweden)

    Anselmo Frizera-Neto

    2011-08-01

    Full Text Available This paper presents the complete development of the Simbiosis Smart Walker. The device is equipped with a set of sensor subsystems to acquire user-machine interaction forces and the temporal evolution of user's feet during gait. The authors present an adaptive filtering technique used for the identification and separation of different components found on the human-machine interaction forces. This technique allowed isolating the components related with the navigational commands and developing a Fuzzy logic controller to guide the device. The Smart Walker was clinically validated at the Spinal Cord Injury Hospital of Toledo - Spain, presenting great acceptability by spinal chord injury patients and clinical staff.

  2. Separation of massive field equation of arbitrary spin in Robertson-Walker space-time

    International Nuclear Information System (INIS)

    Zecca, A.

    2006-01-01

    The massive spin-(3/2) field equation is explicitly integrated in the Robertson-Walker space-time by the Newman Penrose formalism. The solution is obtained by extending a separation procedure previously used to solve the spin-1 equation. The separated time dependence results in two coupled equations depending on the cosmological background evolution. The separated angular equations are explicitly integrated and the eigenvalues determined. The separated radial equations are integrated in the flat space-time case. The separation method of solution is then generalized, by induction, to prove the main result, that is the separability of the massive field equations of arbitrary spin in the Robertson-Walker space-time

  3. 75 FR 49517 - Notice of Intent To Prepare an Environmental Impact Statement for the Walker Ridge Wind Project...

    Science.gov (United States)

    2010-08-13

    ...] Notice of Intent To Prepare an Environmental Impact Statement for the Walker Ridge Wind Project, Lake and...: You may submit comments related to the Walker Ridge Wind Project by any of the following methods: Web... CONTACT: For further information and/or to have your name added to our mailing list, contact Bethney...

  4. Myotonic dystrophy protein kinase (DMPK) induces actin cytoskeletal reorganization and apoptotic-like blebbing in lens cells

    Science.gov (United States)

    Jin, S.; Shimizu, M.; Balasubramanyam, A.; Epstein, H. F.

    2000-01-01

    DMPK, the product of the DM locus, is a member of the same family of serine-threonine protein kinases as the Rho-associated enzymes. In DM, membrane inclusions accumulate in lens fiber cells producing cataracts. Overexpression of DMPK in cultured lens epithelial cells led to apoptotic-like blebbing of the plasma membrane and reorganization of the actin cytoskeleton. Enzymatically active DMPK was necessary for both effects; inactive mutant DMPK protein did not produce either effect. Active RhoA but not constitutive GDP-state mutant protein produced similar effects as DMPK. The similar actions of DMPK and RhoA suggest that they may function in the same regulatory network. The observed effects of DMPK may be relevant to the removal of membrane organelles during normal lens differentiation and the retention of intracellular membranes in DM lenses. Copyright 2000 Wiley-Liss, Inc.

  5. Experience in the management of Dandy-Walker syndrome in an ...

    African Journals Online (AJOL)

    Dandy-Walker Syndrome (DWS) is a congenital brain malformation involving the cerebellum and the fluid spaces around it. There is atresia of foramenofMagendie and Lushka resulting in a complete absence of the part of the brain located between the two cerebellar hemispheres (cerebellarvermis) and cystic dilatation of ...

  6. Monocoque structure for the SKITTER three-legged walker

    Science.gov (United States)

    Bansek, Robert N.; Booth, Andrew J.; Daneman, Steven A.; Dresser, James A.; Haney, Todd G.; Johnson, Gregory R.; Lindzen, Eric C.; Montgomery, Robert C.; Warren, Andrew L.

    1988-01-01

    The SKITTER 2 design is a monocoque version of the proposed lunar three-legged walker. By the definition of monocoque, the body and legs are a shell with no internal ribbing or supports added for absorbing stresses. The purpose of the monocoque is to encase the elements used for power transmission, power supply, and control of the motion. The material for the structure is a vinyl ester resin, Derakane 8084. This material is easily formable and locally obtainable. The body consists of a hexagonally shaped cylinder with truncated hexagonal pyramids on the top and botton. The legs are eight inch diameter cylinders. The legs are comprised of a tibia section and a femur section. The SKITTER 2 is powered by six actuators which provide linear forces that are transformed into rotary torques by a series of chains and sprockets. The joints connect the femur to the body and the tibia to the femur. Surrounding the joints are flexible rubber hoses that fully encase the chains and sprockets. The SKITTER 2 is capable of walking upside down, righting itself after being overturned, and has the ability to perform in many environments. Applications for this walker include lunar transport or drilling, undersea exploration, and operation in severe surroundings such as arctic temperatures or high radiation.

  7. Walker use, but not falls, is associated with lower physical functioning and health of residents in an assisted-living environment

    Directory of Open Access Journals (Sweden)

    Daniel A Andersen

    2007-04-01

    Full Text Available Daniel A Andersen1,5, Bernard A Roos1–4, Damian C Stanziano1,3, Natasha M Gonzalez3, Joseph F Signorile1–31Stein Gerontological Institute, Miami, FL; 2Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Miami, FL; 3Department of Exercise and Sport Sciences, University of Miami, Coral Gables, FL; 4Departments of Medicine and Neurology, University of Miami Miller School of Medicine, Miami, FL; 5Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, FL, USAAbstract: The relationship between perceived health and walker use has seldom been addressed. Concerns over falls and falls risk are precursors to walker use. We compared the SF-36 scores of 26 women and 14 men, mean age 86.8 ± 6.0 years based on walker use and faller status. An analysis of covariance (ANCOVA with age as the covariate, compared groups for the SF-36 constructs and totals score. Significant differences were noted between walker users and nonusers in physical functioning, role limitations due to physical problems, general health, and the total SF-36 score. Pairwise comparisons favored nonusers, while no differences were seen due to faller status. Walker use is associated with lower self-perceptions of physical functioning, role limitations due to physical problems, and general health in assisted-living residents. Faller status is not associated with self-perceived health status. Although walker use aids mobility and lowers the probability of falls, further research is needed to determine if the prescription of assistive devices has a more negative impact on self-perceived health than does falling. This possibility could be explained, in part, by the greater activity levels of those individuals who do not depend on walkers.Keywords: physical function, threshold, walking aid, elderly, perceived health

  8. Quantum features derived from the classical model of a bouncer-walker coupled to a zero-point field

    International Nuclear Information System (INIS)

    Schwabl, H; Mesa Pascasio, J; Fussy, S; Grössing, G

    2012-01-01

    In our bouncer-walker model a quantum is a nonequilibrium steady-state maintained by a permanent throughput of energy. Specifically, we consider a 'particle' as a bouncer whose oscillations are phase-locked with those of the energy-momentum reservoir of the zero-point field (ZPF), and we combine this with the random-walk model of the walker, again driven by the ZPF. Starting with this classical toy model of the bouncer-walker we were able to derive fundamental elements of quantum theory. Here this toy model is revisited with special emphasis on the mechanism of emergence. Especially the derivation of the total energy hω o and the coupling to the ZPF are clarified. For this we make use of a sub-quantum equipartition theorem. It can further be shown that the couplings of both bouncer and walker to the ZPF are identical. Then we follow this path in accordance with Ref. [2], expanding the view from the particle in its rest frame to a particle in motion. The basic features of ballistic diffusion are derived, especially the diffusion constant D, thus providing a missing link between the different approaches of our previous works.

  9. Spruce aphid (Elatobium abietinum Walker) (Hemiptera: Aphididae) [Chapter XXIV

    Science.gov (United States)

    Ann M. Lynch

    2014-01-01

    Elatobium abietinum Walker is a spruce-feeding aphid that in Europe is referred to as the green spruce aphid (Day et al., 1998a) (Fig. 1). However, in North America E. abietinum is known simply as the spruce aphid, while the common name "green spruce aphid" refers to a different species, Cinara fornacula Hottes (Hemiptera: Aphididae) (http://www.entsoc.org/...

  10. Swing-Leg Retraction for Limit Cycle Walkers Improves Disturbance Rejection

    NARCIS (Netherlands)

    Hobbelen, D.G.E.; Wisse, M.

    2008-01-01

    Limit cycle walkers are bipeds that exhibit a stable cyclic gaitwithout requiring local controllability at all times during gait. A well-known example of limit cycle walking is McGeer’s “passive dynamic walking,” but the concept expands to actuated bipeds as involved in this study. One of the

  11. VarWalker: personalized mutation network analysis of putative cancer genes from next-generation sequencing data.

    Science.gov (United States)

    Jia, Peilin; Zhao, Zhongming

    2014-02-01

    A major challenge in interpreting the large volume of mutation data identified by next-generation sequencing (NGS) is to distinguish driver mutations from neutral passenger mutations to facilitate the identification of targetable genes and new drugs. Current approaches are primarily based on mutation frequencies of single-genes, which lack the power to detect infrequently mutated driver genes and ignore functional interconnection and regulation among cancer genes. We propose a novel mutation network method, VarWalker, to prioritize driver genes in large scale cancer mutation data. VarWalker fits generalized additive models for each sample based on sample-specific mutation profiles and builds on the joint frequency of both mutation genes and their close interactors. These interactors are selected and optimized using the Random Walk with Restart algorithm in a protein-protein interaction network. We applied the method in >300 tumor genomes in two large-scale NGS benchmark datasets: 183 lung adenocarcinoma samples and 121 melanoma samples. In each cancer, we derived a consensus mutation subnetwork containing significantly enriched consensus cancer genes and cancer-related functional pathways. These cancer-specific mutation networks were then validated using independent datasets for each cancer. Importantly, VarWalker prioritizes well-known, infrequently mutated genes, which are shown to interact with highly recurrently mutated genes yet have been ignored by conventional single-gene-based approaches. Utilizing VarWalker, we demonstrated that network-assisted approaches can be effectively adapted to facilitate the detection of cancer driver genes in NGS data.

  12. The Dirac equation and the normalization of its solutions in a closed Friedmann- Robertson-Walker universe

    Energy Technology Data Exchange (ETDEWEB)

    Finster, Felix [NWF I-Mathematik, Universitaet Regensburg, D-93040 Regensburg (Germany); Reintjes, Moritz, E-mail: Felix.Finster@mathematik.uni-regensburg.d, E-mail: moritz@math.ucdavis.ed [Mathematics Department, University of California, Davis, CA 95616 (United States)

    2009-05-21

    We set up the Dirac equation in a Friedmann-Robertson-Walker geometry and separate the spatial and time variables. In the case of a closed universe, the spatial dependence is solved explicitly, giving rise to a discrete set of solutions. We compute the probability integral and analyze a spacetime normalization integral. This analysis allows us to introduce the fermionic projector in a closed Friedmann-Robertson-Walker geometry and to specify its global normalization as well as its local form.

  13. The Dirac equation and the normalization of its solutions in a closed Friedmann- Robertson-Walker universe

    International Nuclear Information System (INIS)

    Finster, Felix; Reintjes, Moritz

    2009-01-01

    We set up the Dirac equation in a Friedmann-Robertson-Walker geometry and separate the spatial and time variables. In the case of a closed universe, the spatial dependence is solved explicitly, giving rise to a discrete set of solutions. We compute the probability integral and analyze a spacetime normalization integral. This analysis allows us to introduce the fermionic projector in a closed Friedmann-Robertson-Walker geometry and to specify its global normalization as well as its local form.

  14. Henri Cartier-Bresson / Walker Evans : Photographier l’Amérique (1929-1947

    Directory of Open Access Journals (Sweden)

    François Brunet

    2009-08-01

    Full Text Available Dans un mot adressé en 2001 à Peter Galassi, conservateur de la photographie au MOMA, Henri Cartier-Bresson, alors âgé de quatre-vingt-treize ans, écrivait plaisamment — mais non pas complaisamment : « If it had not been for the challenge of the work of Walker Evans, I don’t think I would have remained a fotographer » (« sans le défi constitué par le travail de Walker Evans, je ne crois pas que je serais resté fotographe ». Pour fêter le centenaire de Cartier-Bresson, c’est ce défi — plutôt ...

  15. Massive bosons interacting with gravity: No standard solutions in Robertson-Walker space-time

    International Nuclear Information System (INIS)

    Zecca, A.

    2009-01-01

    The problem of the interaction of boson and gravitational field is formulated in the Robertson-Walker space-time. It consist the simultaneous solution of the boson and of the Einstein field equation whose source is the energy momentum tensor of the boson field. By direct verification it is shown that the problem does not admit solutions in the class of massive standard solutions, previously determined, of the boson field equation. Also there cannot be solutions, in case of massive interacting boson, that are superpositions of standard solutions. The case of massless boson field is left open. The result is essentially due to the very special form of the Einstein tensor in Robertson-Walker metric.

  16. 75 FR 35265 - Safety Standard for Infant Walkers: Final Rule

    Science.gov (United States)

    2010-06-21

    ... are walking (usually 6 to 15 months old). ASTM F 977-07 defines ``walker'' as ``a mobile unit that... attached to rigid trays. The trays are fastened to bases that have wheels or casters to make them mobile.../jumping. Occupant retention--intended to prevent entrapment by setting requirements for leg openings. The...

  17. Effects of aquatic walking exercise using a walker in a chronic stroke patient.

    Science.gov (United States)

    Matsuda, Tadashi; Akezaki, Yoshiteru

    2017-07-01

    [Purpose] The aim of this study was to examine the usefulness of aquatic walking exercise using a walker for chronic stroke patients. We also examined the psychological effects on the study subject and the primary caregiver before and after aquatic walking exercise. [Subject and Methods] The subject was a 60-year-old male with bilateral paralysis after a cerebrovascular accident. The Fugl-Meyer Assessment (FMA) total score was 116 on the right and 115 on the left. The intervention combined aquatic and land walking exercise. A U-shaped walker was used for both water and land exercise. Continuous walking distance was the measure used to evaluate land walking ability. The psychological effects on the study subject and the primary caregiver were examined with the questionnaire. [Results] In aquatic walking, the mean time to walk 5 m showed an increase from the intervention after two months. After the aquatic walking and land walking combination, continuous walking distance also showed a prolonged trend. In the survey given to the main caregivers, improvements were observed. [Conclusion] Aquatic walking practice using a walker improved motivation in a chronic stroke patient, leading to improved walking ability, with a positive psychological influence on the participant and family caregiver.

  18. Simple autonomous Mars walker

    Science.gov (United States)

    Larimer, Stanley J.; Lisec, Thomas R.; Spiessbach, Andrew J.

    1989-01-01

    Under a contract with NASA's Jet Propulsion Laboratory, Martin Marietta has developed several alternative rover concepts for unmanned exploration of the planet Mars. One of those concepts, the 'Walking Beam', is the subject of this paper. This concept was developed with the goal of achieving many of the capabilities of more sophisticated articulated-leg walkers with a much simpler, more robust, less computationally demanding and more power efficient design. It consists of two large-base tripods nested one within the other which alternately translate with respect to each other along a 5-meter beam to propel the vehicle. The semiautonomous navigation system relies on terrain geometry sensors and tacticle feedback from each foot to autonomously select a path which avoids hazards along a route designated from earth. Both mobility and navigation features of this concept are discussed including a top-level description of the vehicle's physical characteristics, deployment strategy, mobility elements, sensor suite, theory of operation, navigation and control processes, and estimated performance.

  19. Women in History--Madame C. J. Walker 1867-1919

    Science.gov (United States)

    Huber, Germaine W.

    2009-01-01

    This article profiles Madame C. J. Walker. Sarah Breedlove was born on December 23, 1867, the fifth of six children of Owen and Minerva Breedlove. Sarah was the first of the Breedlove children to be born after the end of slavery. Her parents died when she was six or seven years of age. At age fourteen she married Moses McWilliams, who also died in…

  20. Upper-Ocean Heat Balance Processes and the Walker Circulation in CMIP5 Model Projections

    Science.gov (United States)

    Robertson, F. R.; Roberts, J. B.; Funk, C.; Lyon, B.; Ricciardulli, L.

    2012-01-01

    Considerable uncertainty remains as to the importance of mechanisms governing decadal and longer variability of the Walker Circulation, its connection to the tropical climate system, and prospects for tropical climate change in the face of anthropogenic forcing. Most contemporary climate models suggest that in response to elevated CO2 and a warmer but more stratified atmosphere, the required upward mass flux in tropical convection will diminish along with the Walker component of the tropical mean circulation as well. Alternatively, there is also evidence to suggest that the shoaling and increased vertical stratification of the thermocline in the eastern Pacific will enable a muted SST increase there-- preserving or even enhancing some of the dynamical forcing for the Walker cell flow. Over the past decade there have been observational indications of an acceleration in near-surface easterlies, a strengthened Pacific zonal SST gradient, and globally-teleconnected dislocations in precipitation. But is this evidence in support of an ocean dynamical thermostat process posited to accompany anthropogenic forcing, or just residual decadal fluctuations associated with variations in warm and cold ENSO events and other stochastic forcing? From a modeling perspective we try to make headway on this question by examining zonal variations in surface energy fluxes and dynamics governing tropical upper ocean heat content evolution in the WCRP CMIP5 model projections. There is some diversity among model simulations; for example, the CCSM4 indicates net ocean warming over the IndoPacific region while the CSIRO model concentrates separate warming responses over the central Pacific and Indian Ocean regions. The models, as with observations, demonstrate strong local coupling between variations in column water vapor, downward surface longwave radiation and SST; but the spatial patterns of changes in the sign of this relationship differ among models and, for models as a whole, with

  1. Lightweight Biometric Sensing for Walker Classification Using Narrowband RF Links

    Directory of Open Access Journals (Sweden)

    Tong Liu

    2017-12-01

    Full Text Available This article proposes a lightweight biometric sensing system using ubiquitous narrowband radio frequency (RF links for path-dependent walker classification. The fluctuated received signal strength (RSS sequence generated by human motion is used for feature representation. To capture the most discriminative characteristics of individuals, a three-layer RF sensing network is organized for building multiple sampling links at the most common heights of upper limbs, thighs, and lower legs. The optimal parameters of sensing configuration, such as the height of link location and number of fused links, are investigated to improve sensory data distinctions among subjects, and the experimental results suggest that the synergistic sensing by using multiple links can contribute a better performance. This is the new consideration of using RF links in building a biometric sensing system. In addition, two types of classification methods involving vector quantization (VQ and hidden Markov models (HMMs are developed and compared for closed-set walker recognition and verification. Experimental studies in indoor line-of-sight (LOS and non-line-of-sight (NLOS scenarios are conducted to validate the proposed method.

  2. Lightweight Biometric Sensing for Walker Classification Using Narrowband RF Links.

    Science.gov (United States)

    Liu, Tong; Liang, Zhuo-Qian

    2017-12-05

    This article proposes a lightweight biometric sensing system using ubiquitous narrowband radio frequency (RF) links for path-dependent walker classification. The fluctuated received signal strength (RSS) sequence generated by human motion is used for feature representation. To capture the most discriminative characteristics of individuals, a three-layer RF sensing network is organized for building multiple sampling links at the most common heights of upper limbs, thighs, and lower legs. The optimal parameters of sensing configuration, such as the height of link location and number of fused links, are investigated to improve sensory data distinctions among subjects, and the experimental results suggest that the synergistic sensing by using multiple links can contribute a better performance. This is the new consideration of using RF links in building a biometric sensing system. In addition, two types of classification methods involving vector quantization (VQ) and hidden Markov models (HMMs) are developed and compared for closed-set walker recognition and verification. Experimental studies in indoor line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios are conducted to validate the proposed method.

  3. Lightweight Biometric Sensing for Walker Classification Using Narrowband RF Links

    Science.gov (United States)

    Liang, Zhuo-qian

    2017-01-01

    This article proposes a lightweight biometric sensing system using ubiquitous narrowband radio frequency (RF) links for path-dependent walker classification. The fluctuated received signal strength (RSS) sequence generated by human motion is used for feature representation. To capture the most discriminative characteristics of individuals, a three-layer RF sensing network is organized for building multiple sampling links at the most common heights of upper limbs, thighs, and lower legs. The optimal parameters of sensing configuration, such as the height of link location and number of fused links, are investigated to improve sensory data distinctions among subjects, and the experimental results suggest that the synergistic sensing by using multiple links can contribute a better performance. This is the new consideration of using RF links in building a biometric sensing system. In addition, two types of classification methods involving vector quantization (VQ) and hidden Markov models (HMMs) are developed and compared for closed-set walker recognition and verification. Experimental studies in indoor line-of-sight (LOS) and non-line-of-sight (NLOS) scenarios are conducted to validate the proposed method. PMID:29206188

  4. Survival outcome of women with stage IV uterine carcinosarcoma who received neoadjuvant chemotherapy followed by surgery.

    Science.gov (United States)

    Matsuo, Koji; Johnson, Marian S; Im, Dwight D; Ross, Malcolm S; Bush, Stephen H; Yunokawa, Mayu; Blake, Erin A; Takano, Tadao; Klobocista, Merieme M; Hasegawa, Kosei; Ueda, Yutaka; Shida, Masako; Baba, Tsukasa; Satoh, Shinya; Yokoyama, Takuhei; Machida, Hiroko; Ikeda, Yuji; Adachi, Sosuke; Miyake, Takahito M; Iwasaki, Keita; Yanai, Shiori; Takeuchi, Satoshi; Nishimura, Masato; Nagano, Tadayoshi; Takekuma, Munetaka; Shahzad, Mian M K; Pejovic, Tanja; Omatsu, Kohei; Kelley, Joseph L; Ueland, Frederick R; Roman, Lynda D

    2018-03-01

    To examine survival of women with stage IV uterine carcinosarcoma (UCS) who received neoadjuvant chemotherapy followed by hysterectomy. This is a nested case-control study within a retrospective cohort of 1192 UCS cases. Women who received neoadjuvant chemotherapy followed by hysterectomy based-surgery for stage IV UCS (n = 26) were compared to those who had primary hysterectomy-based surgery without neoadjuvant chemotherapy for stage IV UCS (n = 120). Progression-free survival (PFS) and cause-specific survival (CSS) were examined. The most common regimen for neoadjuvant chemotherapy was carboplatin/paclitaxel (53.8%). Median number of neoadjuvant chemotherapy cycles was 4. PFS was similar between the neoadjuvant chemotherapy group and the primary surgery group (unadjusted-hazard ratio [HR] 1.19, 95% confidence interval [CI] 0.75-1.89, P = 0.45). Similarly, CSS was comparable between the two groups (unadjusted-HR 1.13, 95%CI 0.68-1.90, P = 0.64). When the types of neoadjuvant chemotherapy regimens were compared, women who received a carboplatin/paclitaxel regimen had better survival outcomes compared to those who received other regimens: PFS, unadjusted-HR 0.38, 95%CI 0.15-0.93, P = 0.027; and CSS, unadjusted-HR 0.21, 95%CI 0.07-0.61, P = 0.002. Our study found that there is no statistically significant difference in survival between women with stage IV UCS who are tolerated neoadjuvant chemotherapy and those who undergo primary surgery. © 2017 Wiley Periodicals, Inc.

  5. Affinity of 169Yb, 67Ga and 111In for malignant tumor, (1)

    International Nuclear Information System (INIS)

    Ando, Itsuko

    1975-01-01

    The tumor affinity of 169 Yb-citrate, 67 Ga-citrate and 111 In-citrate was examined by using Yoshida sarcoma-bearing rats, and the affinity of these compounds for inflammation was also tested using rats with inflammation induced by croton oil injection. In this investigation there was no great difference in uptake by the tumor tissue of these compounds, but a great difference was observed in the retention value of the blood and uptake rate in the bone. 169 Yb-citrate was cleared rapidly from the blood and was taken mostly into the bone. So the retention values in the soft tissues became very small. On the other hand, 111 In-citrate was slowly and only slightly taken into the bone from the blood, so the retention values in the soft tissue remained relatively high. 67 Ga-citrate showed the intermediate value between the bone uptake rate of 169 Yb-citrate and that of 111 In-citrate. In the following experiments, 169 Yb-citrate and 67 Ga-citrate were compared in four strains: Yoshida sarcoma, Walker carcinosarcoma 256, Sarcoma 180, and Ehrlich tumor. The uptake rate of 169 Yb in tumor tissue was much larger than that of 67 Ga in Ehrlich tumor-bearing mice, but the value of 169 Yb was slightly smaller than those of 67 Ga in Yoshida sarcoma-bearing rats, Walker carcinosarcoma 256-bearing rats and Sarcoma 180-bearing mice. Tumor to organ ratios of 169 Yb, which were most important for tumor scanning, were much larger than those of 67 Ga in all four strains except tumor to bone ratios of 169 Yb. From the above-described facts, it was shown that 169 Yb-citrate had a stronger tumor affinity than 67 Ga-citrate and that the tumor affinity of 169 Yb-citrate was similar in these four strains of tumor bearing animals. These three compounds had a relatively strong affinity with the inflammatory tissue. (auth.)

  6. Epiphanic Awakenings in Raymond Carver's "Cathedral" and Alice Walker's "Everyday Use"

    Science.gov (United States)

    Sadeq, Ala Eddin; Al-Badawi, Mohammed

    2016-01-01

    This paper explores how two short stories from very different backgrounds conclude in a significant epiphany for the characters. Raymond Carver's short story "Cathedral" and Alice Walker's "Everyday Use" are studied to see how the husband in Carver's work is blinder than his visually-impaired overnight guest, and the…

  7. Dissipative Boltzmann-Robertson-Walker cosmologies

    International Nuclear Information System (INIS)

    Hiscock, W.A.; Salmonson, J.

    1991-01-01

    The equations governing a flat Robertson-Walker cosmological model containing a dissipative Boltzmann gas are integrated numerically. The bulk viscous stress is modeled using the Eckart and Israel-Stewart theories of dissipative relativistic fluids; the resulting cosmologies are compared and contrasted. The Eckart models are shown to always differ in a significant quantitative way from the Israel-Stewart models. It thus appears inappropriate to use the pathological (nonhyperbolic) Eckart theory for cosmological applications. For large bulk viscosities, both cosmological models approach asymptotic nonequilibrium states; in the Eckart model the total pressure is negative, while in the Israel-Stewart model the total pressure is asymptotically zero. The Eckart model also expands more rapidly than the Israel-Stewart models. These results suggest that ''bulk-viscous'' inflation may be an artifact of using a pathological fluid theory such as the Eckart theory

  8. The Dirac equation and the normalization of its solutions in a closed Friedmann- Robertson-Walker universe

    Science.gov (United States)

    Finster, Felix; Reintjes, Moritz

    2009-05-01

    We set up the Dirac equation in a Friedmann-Robertson-Walker geometry and separate the spatial and time variables. In the case of a closed universe, the spatial dependence is solved explicitly, giving rise to a discrete set of solutions. We compute the probability integral and analyze a spacetime normalization integral. This analysis allows us to introduce the fermionic projector in a closed Friedmann-Robertson-Walker geometry and to specify its global normalization as well as its local form. First author supported in part by the Deutsche Forschungsgemeinschaft.

  9. Draft Title V Operating Permit: Andeavor Field Services, LLC - Walker Hollow Compressor Station

    Science.gov (United States)

    Draft Operating Permit (Permit Number: V-UO-000979-2017.00), statement of basis, public notice bulletin, and the administrative permit docket (application and other supporting documents) for the Andeavor Walker Hollow Compressor Station.

  10. Prenatal diagnosis of the Dandy-Walker syndrome by sonography and computed tomography

    International Nuclear Information System (INIS)

    Toelly, E.; Ebner, F.; Oberbauer, R.W.

    1984-01-01

    A case of Dandy-Walker-syndrome is presented, comparing the value of sonography and CT in intrauterine diagnosis. Together with a review of the literature of the subject, pathogenesis, morphology and prognosis in regard to the psychomotoric development are discussed. (orig.) [de

  11. ARG-walker: inference of individual specific strengths of meiotic recombination hotspots by population genomics analysis.

    Science.gov (United States)

    Chen, Hao; Yang, Peng; Guo, Jing; Kwoh, Chee Keong; Przytycka, Teresa M; Zheng, Jie

    2015-01-01

    Meiotic recombination hotspots play important roles in various aspects of genomics, but the underlying mechanisms for regulating the locations and strengths of recombination hotspots are not yet fully revealed. Most existing algorithms for estimating recombination rates from sequence polymorphism data can only output average recombination rates of a population, although there is evidence for the heterogeneity in recombination rates among individuals. For genome-wide association studies (GWAS) of recombination hotspots, an efficient algorithm that estimates the individualized strengths of recombination hotspots is highly desirable. In this work, we propose a novel graph mining algorithm named ARG-walker, based on random walks on ancestral recombination graphs (ARG), to estimate individual-specific recombination hotspot strengths. Extensive simulations demonstrate that ARG-walker is able to distinguish the hot allele of a recombination hotspot from the cold allele. Integrated with output of ARG-walker, we performed GWAS on the phased haplotype data of the 22 autosome chromosomes of the HapMap Asian population samples of Chinese and Japanese (JPT+CHB). Significant cis-regulatory signals have been detected, which is corroborated by the enrichment of the well-known 13-mer motif CCNCCNTNNCCNC of PRDM9 protein. Moreover, two new DNA motifs have been identified in the flanking regions of the significantly associated SNPs (single nucleotide polymorphisms), which are likely to be new cis-regulatory elements of meiotic recombination hotspots of the human genome. Our results on both simulated and real data suggest that ARG-walker is a promising new method for estimating the individual recombination variations. In the future, it could be used to uncover the mechanisms of recombination regulation and human diseases related with recombination hotspots.

  12. Draft Title V Operating Permit: Andeavor Field Services, LLC - Walker Hollow Compressor Station

    Science.gov (United States)

    Draft Title V Operating Permit, statement of basis, public notice bulletin, and the administrative permit docket (application and other supporting documents) for the Draft Part 71 Permit for Andeavor Field Services, LLC - Walker Hollow CS.

  13. Walker-Warburg syndrome

    Directory of Open Access Journals (Sweden)

    Schachter Harry

    2006-08-01

    Full Text Available Abstract Walker-Warburg Syndrome (WWS is a rare form of autosomal recessive congenital muscular dystrophy associated with brain and eye abnormalities. WWS has a worldwide distribution. The overall incidence is unknown but a survey in North-eastern Italy has reported an incidence rate of 1.2 per 100,000 live births. It is the most severe form of congenital muscular dystrophy with most children dying before the age of three years. WWS presents at birth with generalized hypotonia, muscle weakness, developmental delay with mental retardation and occasional seizures. It is associated with type II cobblestone lissencephaly, hydrocephalus, cerebellar malformations, eye abnormalities and congenital muscular dystrophy characterized by hypoglycosylation of α-dystroglycan. Several genes have been implicated in the etiology of WWS, and others are as yet unknown. Several mutations were found in the Protein O-Mannosyltransferase 1 and 2 (POMT1 and POMT2 genes, and one mutation was found in each of the fukutin and fukutin-related protein (FKRP genes. Laboratory investigations usually show elevated creatine kinase, myopathic/dystrophic muscle pathology and altered α-dystroglycan. Antenatal diagnosis is possible in families with known mutations. Prenatal ultrasound may be helpful for diagnosis in families where the molecular defect is unknown. No specific treatment is available. Management is only supportive and preventive.

  14. The Deep Semantics of Imagery in Alice Walker's The Color Purple ...

    African Journals Online (AJOL)

    Hinged on this theoretical framework, the paper assesses the deep semantics of imagery in Walker's The Color Purple and highlights the salient non-ostensive references of the text and the new world it proposes. The analysis reveals the key to a deeper and broader perception of God, the imperativeness of equality of ...

  15. The key role of ozone depleting substances in weakening the Walker Circulation over the second half of the 20th Century

    Science.gov (United States)

    Bellomo, K.; Polvani, L. M.

    2017-12-01

    It is widely believed that the Walker Circulation will weaken in response to increasing greenhouse gases (GHG) by the end of the 21st century. But over the 20th century, the existence of a statistical significant weakening trends in the observations remains unclear. We here present new modelling evidence showing that Ozone Depleting Substances (ODS) may have significantly contributed to the weakening of the Walker Circulation over the years 1955-2005. While the primary impact of increasing ODS has been the formation of the ozone hole, it is perhaps not as widely appreciated that ODS are also powerful greenhouse gases. Using an ensemble of integrations with the the Whole Atmosphere Chemistry Climate Model, we show that the surface warming caused by increasing ODS over the second half of the 20th century causes a statistically significant weakening of the Walker Circulation in the model. In fact, we find that the increase of the other well-mixed GHG alone leads to a strengthening, not a weakening of the Walker Circulation, over that period in our model. When ODS concentrations are held fixed at 1950's levels, the effect of the other GHG is not sufficient, and a warming delay in the eastern tropical Pacific SST leads to an increase in the east-west SST gradient which is accompanied by a strengthening of the Walker Circulation. But, when the forcing from ODS is added in, the additional radiative forcing causes the eastern Pacific to warm faster, and the trend in the Walker Circulation reverses sign and becomes negative over the second half of the 20th century.

  16. Walkers' Perspectives on Nature Management Strategies: Nature Restoration in a National Park

    NARCIS (Netherlands)

    Marwijk, van R.B.M.

    2008-01-01

    Leisure practices and public space, third chapter. Ramona van Marwijk is part of a bigger research projecton time-space behavioural patterns in a landscape where nature development and recreational values are combined. She is interested in what walkers in the Dutch National Park Dwingelderveld think

  17. Dandy–Walker malformation is a rare cause of syringomyelia in adults

    Directory of Open Access Journals (Sweden)

    G. Yu. Evzikov

    2017-01-01

    Full Text Available Neural tube defects are the most common central nervous system malformation. Dandy–Walker malformation (DWM is a rare abnormality of the posterior cranial fossa, which is generally diagnosed in the prenatal period or early infancy.The paper describes a case of the late clinical manifestation of DWM, which has caused syringomyelia. All variants of pathological changes within the Dandy–Walker complex very rarely become a cause of syringomyelia. Only four cases of DWM, in which syringomyelia was found in adults, are known.The authors believe that formation of syringomyelia cysts in these patients is associated with the impaired circulation of normal cerebrospinal fluid between the superior cistern and the subarachnoid spaces of the spinal cord due to the caudal dislocation of the cyst formed in the fourth ventricle.Decompression of the craniovertebral junction, by resecting the caudal portion of the cyst in the foramen magnum, and repair of the free communication between the superior cistern and the cerebrospinal fluid spaces of the spinal cord, which is complemented by duroplasty, are pointed out to be an optimal treatment in these patients.

  18. Accommodation of missing shear strain in the Central Walker Lane, western North America: Constraints from dense GPS measurements

    Science.gov (United States)

    Bormann, Jayne M.; Hammond, William C.; Kreemer, Corné; Blewitt, Geoffrey

    2016-04-01

    We present 264 new interseismic GPS velocities from the Mobile Array of GPS for Nevada Transtension (MAGNET) and continuous GPS networks that measure Pacific-North American plate boundary deformation in the Central Walker Lane. Relative to a North America-fixed reference frame, northwestward velocities increase smoothly from ∼4 mm/yr in the Basin and Range province to 12.2 mm/yr in the central Sierra Nevada resulting in a Central Walker Lane deformation budget of ∼8 mm/yr. We use an elastic block model to estimate fault slip and block rotation rates and patterns of deformation from the GPS velocities. Right-lateral shear is distributed throughout the Central Walker Lane with strike-slip rates generally Bodie Hills, Carson Domain, and Mina Deflection are between 1-4°/Myr, lower than published paleomagnetic rotation rates, suggesting that block rotation rates have decreased since the Late to Middle Miocene.

  19. Risks of vaginal breech delivery at term compared with elective cesarean section - reply to comments by Walker and Powell, and Sholapurkar

    NARCIS (Netherlands)

    Vlemmix, Floortje; Mol, Ben Willem; Kok, Marjolein

    2015-01-01

    We thank both Walker and Powell (1), as well as Sholapurkar (2) for their interest in our work. Walker and Powell note that the risk of neonatal mortality for planned vaginal breech delivery (VBD) in our study is lower than the mortality reported in the term breech trial and comparable to the risk

  20. Trans-sphenoidal encephalocele in association with Dandy-Walker complex and cardiovascular anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Joy, H.M.; Barker, C.S. [Wessex Neurological Centre, Southampton (United Kingdom); Small, J.H. [Dept. of Radiology, Royal Bournemouth Hospital (United Kingdom); Armitage, M. [Bournemouth Diabetes and Endocrine Centre, Royal Bournemouth Hospital (United Kingdom)

    2001-01-01

    We present a case of trans-sphenoidal encephalomeningocele in association with a posterior cranial fossa malformation which fulfils the criteria for the Dandy-Walker complex. Congenital cardiovascular defects were also present. An abnormality of neural crest development may be responsible for the combined occurrence of these anomalies. (orig.)

  1. Do Canes or Walkers Make Any Difference? NonUse and Fall Injuries.

    Science.gov (United States)

    Luz, Clare; Bush, Tamara; Shen, Xiaoxi

    2017-04-01

    Examine patterns of cane and walker use as related to falls and fall injuries. Among people who fall at home, most do not have an assistive device with them when they fall. Nonusers who fall sustain more severe injuries. This was a cross-sectional study using a self-administered written survey completed by 262 people aged 60 and older who were community dwelling, cognitively intact, and current cane/walker users with a history of falls. They were recruited through clinical practice sites, churches, and senior housing in central Michigan. Outcomes of interest included patterns of device use, reasons for nonuse, device use at time of fall, and fall-related injuries. Seventy-five percent of respondents who fell were not using their device at the time of fall despite stating that canes help prevent falls. Reasons for nonuse included believing it was not needed, forgetfulness, the device made them feel old, and inaccessibility. Perceived risk was not high enough to engage in self-protective behavior. However, nonuse led to a significantly higher proportion of falls resulting in surgery than among device users. Among respondents requiring surgery, 100% were nonusers. Most respondents never received a home safety evaluation (68%) and only 50% received training on proper device use. Providers must place increased emphasis on the importance of cane/walker use for injury prevention through patient education to promote personal relevance, proper fitting, and training. New strategies are needed to improve device acceptability and accessibility. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. Tachyons in Robertson-Walker Cosmology

    CERN Document Server

    Tomaschitz, R

    1998-01-01

    Superluminal signal transfer is studied in the context of a preferred cosmic frame of reference provided by the galactic background. The receding galaxies constitute a frame of absolute rest, in which the energy of tachyons (faster-than-light particles) is unambiguously defined as a positive quantity. The causality violation which arises in relativistic tachyonic theories is avoided. We define interactions of particles and tachyons in terms of elastic head-on collisions and energy-momentum conservation. To compare the theory developed with existing relativistic theories, tachyons are studied at first in a Minkowski universe, and the causality of a superluminal communication process is analyzed. Then we discuss the dynamics of tachyons in a Robertson-Walker universe with linear expansion factor and negatively curved three-space. We point out the consequences that the space expansion has on tachyons, like a finite life-time in the frame of absolute rest, and multiple images in the rest frames of moving observer...

  3. A 'water walkers' exercise program for the elderly.

    Science.gov (United States)

    Heyneman, C A; Premo, D E

    1992-01-01

    Recent studies have shown that older people, stereotyped as weak, frail, and inactive, demonstrate an equal capacity to reap the physical and psychological benefits of recreational exercise. A low cost aquatic exercise program is proposed that is geared towards those persons who, because of their physical limitations, are unable to participate in the more traditional walking or low-impact aerobics programs currently available for seniors. A water-based program would allow these people to gain all the advantages of land-based exercise with out stress or strain on arthritic joints. In addition, the use of water walkers (a buoyancy device which attaches easily around the waist) would allow total freedom of movement without fear of deep water. Those with various levels of disability could, therefore, participate at their own pace. Two programs, including transportation, would be provided twice a week for 8 weeks each. An individual 45-minute session would consist of a warm-up period with gentle stretching, a cardiovascular segment, a cool-down period, strength-training, and a final stretching time. All exercises would be conducted with participants wearing the water walkers, allowing total immersion to the shoulder. Free to move about the pool, they would be encouraged to interact socially with one another. The results of the program would be determined by measuring range of motion, cardiovascular endurance, and strength before and after each 8-week session. Participants' level of self confidence and life satisfaction will be estimated and any psychological improvement will be documented.

  4. Contribution of radiosensitivity study for Walker 256 tumor in rats. Association of early immunization with action of ionized radiation

    International Nuclear Information System (INIS)

    Sakate, A.T.Y.

    1979-01-01

    The suspension of tumoral cells from Walker 256 were irradiated with doses of 2.500, 4.500, 5.000, 5.500 and 7.500 rad for determining the attenuation dose. The suspension of inactives tumoral cells were injected in rats for verifying the immunized effects in relation of active Walker tumor. After be certified the growth of tumor, the rats were irradiated with cobalt 60 and was verified the decrease of tumor. (author)

  5. On the minimal vacuum definition for spin 1 massive fields in Robertson-Walker universes

    International Nuclear Information System (INIS)

    Castagnino, M.; Laciana, C.; Chimento, L.

    1986-01-01

    A definition of quantum vacuum is introduced for spin 1, massive, neutral fields, in spatially flat Robertson-Walker universes. For this definition all relevant observables turn out to be devoid of ultraviolet divergencies. (author)

  6. How do walkers behave when crossing the way of a mobile robot that replicates human interaction rules?

    Science.gov (United States)

    Vassallo, Christian; Olivier, Anne-Hélène; Souères, Philippe; Crétual, Armel; Stasse, Olivier; Pettré, Julien

    2018-02-01

    Previous studies showed the existence of implicit interaction rules shared by human walkers when crossing each other. Especially, each walker contributes to the collision avoidance task and the crossing order, as set at the beginning, is preserved along the interaction. This order determines the adaptation strategy: the first arrived increases his/her advance by slightly accelerating and changing his/her heading, whereas the second one slows down and moves in the opposite direction. In this study, we analyzed the behavior of human walkers crossing the trajectory of a mobile robot that was programmed to reproduce this human avoidance strategy. In contrast with a previous study, which showed that humans mostly prefer to give the way to a non-reactive robot, we observed similar behaviors between human-human avoidance and human-robot avoidance when the robot replicates the human interaction rules. We discuss this result in relation with the importance of controlling robots in a human-like way in order to ease their cohabitation with humans. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Bubble merging in breathing DNA as a vicious walker problem in opposite potentials

    DEFF Research Database (Denmark)

    Pedersen, Jonas Nyvold; Hansen, Mikael Sonne; Novotny, Tomas

    2009-01-01

    on the problem of two vicious walkers in opposite potentials. We also present a discrete master equation approach to the bubble coalescence problem. Numerical evaluation and stochastic simulation of the master equation show excellent agreement with the results from the continuum approach. Given...

  8. Fuzzy Random Walkers with Second Order Bounds: An Asymmetric Analysis

    Directory of Open Access Journals (Sweden)

    Georgios Drakopoulos

    2017-03-01

    Full Text Available Edge-fuzzy graphs constitute an essential modeling paradigm across a broad spectrum of domains ranging from artificial intelligence to computational neuroscience and social network analysis. Under this model, fundamental graph properties such as edge length and graph diameter become stochastic and as such they are consequently expressed in probabilistic terms. Thus, algorithms for fuzzy graph analysis must rely on non-deterministic design principles. One such principle is Random Walker, which is based on a virtual entity and selects either edges or, like in this case, vertices of a fuzzy graph to visit. This allows the estimation of global graph properties through a long sequence of local decisions, making it a viable strategy candidate for graph processing software relying on native graph databases such as Neo4j. As a concrete example, Chebyshev Walktrap, a heuristic fuzzy community discovery algorithm relying on second order statistics and on the teleportation of the Random Walker, is proposed and its performance, expressed in terms of community coherence and number of vertex visits, is compared to the previously proposed algorithms of Markov Walktrap, Fuzzy Walktrap, and Fuzzy Newman–Girvan. In order to facilitate this comparison, a metric based on the asymmetric metrics of Tversky index and Kullback–Leibler divergence is used.

  9. Ground reaction forces of Olympic and World Championship race walkers.

    Science.gov (United States)

    Hanley, Brian; Bissas, Athanassios

    2016-01-01

    Race walking is an Olympic event where no visible loss of contact should occur and the knee must be straightened until midstance. The purpose of this study was to analyse ground reaction forces of world-class race walkers and associate them with key spatiotemporal variables. Nineteen athletes race walked along an indoor track and made contact with two force plates (1000 Hz) while being filmed using high-speed videography (100 Hz). Race walking speed was correlated with flight time (r = .46, p = .049) and flight distance (r = .69, p = .001). The knee's movement from hyperextension to flexion during late stance meant the vertical push-off force that followed midstance was smaller than the earlier loading peak (p push-off forces (r = .60, p = .011). Lower fluctuations in speed during stance were associated with higher stride frequencies (r = .69, p = .001), and highlighted the importance of avoiding too much braking in early stance. The flattened trajectory and consequential decrease in vertical propulsion might help the race walker avoid visible loss of contact (although non-visible flight times were useful in increasing stride length), while a narrow stride width was important in reducing peak forces in all three directions and could improve movement efficiency.

  10. A class of almost equilibrium states in Robertson-Walker spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Kueskue, Muharrem

    2008-11-06

    In quantum field theory in curved spacetimes the construction of the algebra of observables of linear fields is today well understood. However, it remains a non-trivial task to construct physically meaningful states on the algebra. For instance, we are in the unsatisfactory situation that there exist no examples of states suited to describe local thermal equilibrium in a non-stationary spacetime. In this thesis, we construct a class of states for the Klein-Gordon field in Robertson-Walker spacetimes, which seem to provide the first example of thermal states in a spacetime without time translation symmetry. More precisely, in the setting of real, linear, scalar fields in Robertson-Walker spacetimes we define on the set of homogeneous, isotropic, quasi-free states a free energy functional that is based on the averaged energy density measured by an isotropic observer along his worldline. This functional is well defined and lower bounded by a suitable quantum energy inequality. Subsequently, we minimize this functional and obtain states that we interpret as 'almost equilibrium states'. It turns out that the states of low energy are the ground states of the almost equilibrium states. Finally, we prove that the almost equilibrium states satisfy the Hadamard condition, which qualifies them as physically meaningful states. (orig.)

  11. Third annual Walker Branch watershed research symposium: Programs and abstracts

    International Nuclear Information System (INIS)

    1992-03-01

    The methods and concepts of watershed research, originally applied in an experimental or monitoring mode to relatively small catchments, are increasingly being used at larger scales and for specific applied problems. Research at Oak Ridge National Laboratory, the Tennessee Valley Authority, the US Forest Service, and other agencies and institutions participating in this symposium reflects research over a broad range of spatial scales. These research projects address the basic atmospheric, geophysical, biogeochemical, and biological processes that regulate the responses of forested ecosystems to natural environmental variation and anthropogenic stresses. Regional and global issues addressed by presentations include emissions of carbon dioxide, methane, and other hydrocarbons; deposition of sulfate, nitrate, and mercury; land-use changes; biological diversity; droughts; and water quality. The Department of Energy's local research site, Walker Branch Watershed, is a long-term ecosystem research project initiated on the Oak Ridge Reservation in 1967. Walker Branch provides a well-characterized site where many of these methods can be tested and applied.In addition, other large-scale experiments represented in this symposium include experiments on the effects of clearcutting and burning on forest structure and productivity associated with Coweeta Hydrologic Laboratory, and whole-tree ozone exposure chambers constructed by TVA and ORNL researchers

  12. A class of almost equilibrium states in Robertson-Walker spacetimes

    International Nuclear Information System (INIS)

    Kueskue, Muharrem

    2008-01-01

    In quantum field theory in curved spacetimes the construction of the algebra of observables of linear fields is today well understood. However, it remains a non-trivial task to construct physically meaningful states on the algebra. For instance, we are in the unsatisfactory situation that there exist no examples of states suited to describe local thermal equilibrium in a non-stationary spacetime. In this thesis, we construct a class of states for the Klein-Gordon field in Robertson-Walker spacetimes, which seem to provide the first example of thermal states in a spacetime without time translation symmetry. More precisely, in the setting of real, linear, scalar fields in Robertson-Walker spacetimes we define on the set of homogeneous, isotropic, quasi-free states a free energy functional that is based on the averaged energy density measured by an isotropic observer along his worldline. This functional is well defined and lower bounded by a suitable quantum energy inequality. Subsequently, we minimize this functional and obtain states that we interpret as 'almost equilibrium states'. It turns out that the states of low energy are the ground states of the almost equilibrium states. Finally, we prove that the almost equilibrium states satisfy the Hadamard condition, which qualifies them as physically meaningful states. (orig.)

  13. Blue Rubber Bleb Nevus Syndrome Showing Vascular Skin Lesions Predominantly on the Face

    Directory of Open Access Journals (Sweden)

    Ayumi Korekawa

    2015-07-01

    Full Text Available An 81-year-old Japanese man presented with dark blue papules and nodules on his face. There were multiple soft papules and nodules, dark blue in color, compressive, and ranging in size from 2 to 10 mm. A few similar lesions were seen on the patient's right dorsal second toe and right buccal mucosa. There were no skin lesions on his trunk and upper limbs. The patient's past history did not include gastrointestinal bleeding or anemia. Histopathological examination showed dilated vascular spaces lined by the normal epithelium extending beneath the dermis and into the subcutaneous fat. Endoscopy of the gastrointestinal tract to check for colon involvement was not performed. X-ray images of the limbs revealed no abnormalities in the bones or joints. Laboratory investigations did not show anemia. Although we failed to confirm a diagnosis by endoscopy, the skin lesions, histopathological findings, lack of abnormal X-ray findings, and the presence of oral lesions as a part of gastrointestinal tract guided the diagnosis of blue rubber bleb nevus syndrome (BRBNS. Skin lesions of BRBNS occur predominantly on the trunk and upper limbs. However, the present case showed multiple skin lesions predominantly on the face. Therefore, it is important for clinicians to know about a possible atypical distribution of skin lesions in BRBNS.

  14. Collateral Damage: Veterans and Domestic Violence in Mari Sandoz's "The Tom-Walker"

    Science.gov (United States)

    Bahr, Kathy

    2010-01-01

    "The Tom-Walker" combines the best of Sandoz's realism with her worst attempts at moralizing. Unable to divine exactly what political configuration right-wing post-World War II sentiments might take, Sandoz nevertheless feared a fascist uprising in this country. Perhaps because these concerns dominated her thoughts at the time, she allowed her…

  15. On Maximal Surfaces in Certain Non-Flat 3-Dimensional Robertson-Walker Spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Romero, Alfonso, E-mail: aromero@ugr.es [Universidad de Granada, Departamento de Geometria y Topologia (Spain); Rubio, Rafael M., E-mail: rmrubio@uco.es [Universidad de Cordoba, Departamento de Matematicas, Campus de Rabanales (Spain)

    2012-09-15

    An upper bound for the integral, on a geodesic disc, of the squared length of the gradient of a distinguished function on any maximal surface in certain non-flat 3-dimensional Robertson-Walker spacetimes is obtained. As an application, a new proof of a known Calabi-Bernstein's theorem is given.

  16. Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats

    International Nuclear Information System (INIS)

    Barbosa, A.L.R.; Pinheiro, C.A.; Oliveira, G.J.; Torres, J.N.L.; Moraes, M.O.; Ribeiro, R.A.; Vale, M.L.; Souza, M.H.L.P.

    2012-01-01

    Implantation of Walker 256 tumor decreases acute systemic inflammation in rats. Inflammatory hyperalgesia is one of the most important events of acute inflammation. The L-arginine/NO/cGMP/K + ATP pathway has been proposed as the mechanism of peripheral antinociception mediated by several drugs and physical exercise. The objective of this study was to investigate a possible involvement of the NO/cGMP/K + ATP pathway in antinociception induced in Walker 256 tumor-bearing male Wistar rats (180-220 g). The groups consisted of 5-6 animals. Mechanical inflammatory hypernociception was evaluated using an electronic version of the von Frey test. Walker tumor (4th and 7th day post-implantation) reduced prostaglandin E 2 - (PGE 2 , 400 ng/paw; 50 µL; intraplantar injection) and carrageenan-induced hypernociception (500 µg/paw; 100 µL; intraplantar injection). Walker tumor-induced analgesia was reversed (99.3% for carrageenan and 77.2% for PGE 2 ) by a selective inhibitor of nitric oxide synthase (L-NAME; 90 mg/kg, ip) and L-arginine (200 mg/kg, ip), which prevented (80% for carrageenan and 65% for PGE 2 ) the effect of L-NAME. Treatment with the soluble guanylyl cyclase inhibitor ODQ (100% for carrageenan and 95% for PGE 2 ; 8 µg/paw) and the ATP-sensitive K + channel (KATP) blocker glibenclamide (87.5% for carrageenan and 100% for PGE 2 ; 160 µg/paw) reversed the antinociceptive effect of tumor bearing in a statistically significant manner (P < 0.05). The present study confirmed an intrinsic peripheral antinociceptive effect of Walker tumor bearing in rats. This antinociceptive effect seemed to be mediated by activation of the NO/cGMP pathway followed by the opening of KATP channels

  17. Radiotracer studies on protein metabolism in different focuses of growth in vivo

    International Nuclear Information System (INIS)

    Rapoport, E.A.; Konikova, A.S.

    1979-01-01

    The role of various components of protein turnover in the liver growth induced by partial hepatectomy or phenobarbital as well as in malignant tumours has been studied with a radiotracer method. The ratio of the utilized precursors of exo- and endogenous origin during the formation of protein in focuses of growth, is labile, depends on a number of factors and varies even in the subcellular structures of the cell nucleus. It is probable that due to their reutilization through transreactions the protein structural units have in some focuses of growth and during formation of some proteins a definite superiority over the free aminoacids. It is also shown that the release of proteins and their degradation products from Walker 256 carcinosarcoma and the reutilization of proteins and their degradation products by sarcoma M-1 contribute to the protein turnover in the tumours. 8author)

  18. FreeWalker: a smart insole for longitudinal gait analysis.

    Science.gov (United States)

    Wang, Baitong; Rajput, Kuldeep Singh; Tam, Wing-Kin; Tung, Anthony K H; Yang, Zhi

    2015-08-01

    Gait analysis is an important diagnostic measure to investigate the pattern of walking. Traditional gait analysis is generally carried out in a gait lab, with equipped force and body tracking sensors, which needs a trained medical professional to interpret the results. This procedure is tedious, expensive, and unreliable and makes it difficult to track the progress across multiple visits. In this paper, we present a smart insole called FreeWalker, which provides quantitative gait analysis outside the confinement of traditional lab, at low- cost. The insole consists of eight pressure sensors and two motion tracking sensors, i.e. 3-axis accelerometer and 3-axis gyroscope. This enables measurement of under-foot pressure distribution and motion sequences in real-time. The insole is enabled with onboard SD card as well as wireless data transmission, which help in continuous gait-cycle analysis. The data is then sent to a gateway, for analysis and interpretation of data, using a user interface where gait features are graphically displayed. We also present validation result of a subject's left foot, who was asked to perform a specific task. Experiment results show that we could achieve a data-sampling rate of over 1 KHz, transmitting data up to a distance of 20 meter and maintain a battery life of around 24 hours. Taking advantage of these features, FreeWalker can be used in various applications, like medical diagnosis, rehabilitation, sports and entertainment.

  19. Optimal handgrip height of four-wheeled walker on various road conditions to reduce muscular load for elderly users with steady walking.

    Science.gov (United States)

    Takanokura, Masato

    2010-03-22

    A four-wheeled walker is a valuable tool for assisting elderly persons with walking. The handgrip height is one of the most important factor determining the usefulness of the walker. However, the optimal handgrip height for elderly users has not been considered from a biomechanical viewpoint. In this study, the handgrip height was optimized by a two-dimensional mechanical model to reduce muscular loads in the lower body as well as in the upper body with various road conditions during steady walking. A critical height of the handgrip existed at 48% of the body height for the user regardless of gender and body dimension. A lower handgrip relieved muscular load for stooping users with a lower standing height. The stooping user pushed the handgrip strongly in the perpendicular direction by leaning the upper body on the walker. However, upright users with a higher standing height should use a four-wheeled walker with a higher handgrip for maintaining his or her upright posture. For downhill movement, the optimal handgrip height depended on the slope angle and the friction coefficient between the road and the wheels of the walker. On a low-friction downhill such as asphalt with a steeper slope angle, the user was required to maintain an erect trunk with a higher handgrip and to press on the handgrip strongly in the perpendicular direction. Movement on a low-friction road was easier for users on a flat road and an uphill road, but it compelled distinct effort from users when moving downhill. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

  20. Decoherence induced by a chaotic enviroment: A quantum walker with a complex coin

    International Nuclear Information System (INIS)

    Ermann, Leonardo; Paz, Juan Pablo; Saraceno, Marcos

    2006-01-01

    We study the differences between the processes of decoherence induced by chaotic and regular environments. For this we analyze a family of simple models that contain both regular and chaotic environments. In all cases the system of interest is a ''quantum walker,'' i.e., a quantum particle that can move on a lattice with a finite number of sites. The walker interacts with an environment which has a D-dimensional Hilbert space. The results we obtain suggest that regular and chaotic environments are not distinguishable from each other in a (short) time scale t*, which scales with the dimensionality of the environment as t*∝log 2 (D). However, chaotic environments continue to be effective over exponentially longer time scales while regular environments tend to reach saturation much sooner. We present both numerical and analytical results supporting this conclusion. The family of chaotic evolutions we consider includes the so-called quantum multibaker map as a particular case

  1. The captain class : the hidden force that creates the world's greatest teams / Sam Walker

    Trove (Australia)

    Walker, Sam

    2017-01-01

    ... it is. It's not the coach. It's not the star. It's not chemistry. It's not a strategy. It's something else entirely. Several years ago, Sam Walker set out to answer one of the most hotly debated questions in sports ...

  2. Difficulties with Prenatal Diagnosis of the Walker-Warburg Syndrome

    International Nuclear Information System (INIS)

    Low, A.S.C.; Lee, S.L.; Tan, A.S.A.; Chan, D.K.L.; Chan, L.L.

    2005-01-01

    We describe a postnatally diagnosed case of Walker-Warburg syndrome - a form of congenital muscular dystrophy with lissencephaly and eye abnormalities. We reviewed the literature to highlight its clinico-radiological diagnostic features and discuss the difficulties encountered with prenatal diagnosis, especially in cases with no positive family history. An increased awareness of this rare but lethal condition, and a high index of suspicion during routine antenatal ultrasound, could prompt further advanced fetal ultrasonography and magnetic resonance imaging, and aid in timely prenatal diagnosis, management, and counseling. Brain/brainstem, congenital, magnetic resonance imaging, obstetrics, pediatrics, ultrasound

  3. Difficulties with Prenatal Diagnosis of the Walker-Warburg Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Low, A.S.C.; Lee, S.L.; Tan, A.S.A.; Chan, D.K.L.; Chan, L.L. [Singapore General Hospital (Singapore). Depts. of Diagnostic Radiology, Obstetrics and Gynecology and Neonatology

    2005-10-01

    We describe a postnatally diagnosed case of Walker-Warburg syndrome - a form of congenital muscular dystrophy with lissencephaly and eye abnormalities. We reviewed the literature to highlight its clinico-radiological diagnostic features and discuss the difficulties encountered with prenatal diagnosis, especially in cases with no positive family history. An increased awareness of this rare but lethal condition, and a high index of suspicion during routine antenatal ultrasound, could prompt further advanced fetal ultrasonography and magnetic resonance imaging, and aid in timely prenatal diagnosis, management, and counseling. Brain/brainstem, congenital, magnetic resonance imaging, obstetrics, pediatrics, ultrasound.

  4. Dandy-Walker syndrome in adult mimicking myasthenia gravis Síndrome de Dandy-Walker em adulto simulando miastenia gravis

    Directory of Open Access Journals (Sweden)

    Juliana Cardoso

    2007-03-01

    Full Text Available The Dandy-Walker syndrome (DWS is a rare posterior fossa malformation. The DWS can occur associated with other brain or systemic malformations, but ocular abnormalities in this disease are rare and clinical findings mimicking myasthenia gravis have not been described to date. We report a 23-year-old woman who presented mild limitation of the ocular movements with progressive palpebral ptosis, which changed in intensity during the day. The investigation showed negative anti-acetylcholine receptor antibody, repetitive nerve stimulation and "Tensilon test", but the brain magnetic resonance image reveals DWS with hydrocephalus associated with calosal dysgenesis. The characteristic of disease, clinical manifestations and pathologic features, specially the clinical evaluation of ocular abnormalities in suspicion of DWS, including the MG in differential diagnosis are discussed.A síndrome de Dandy-Walker (DWS é uma rara malformação da fossa posterior que pode ocorrer associada com outras malformações cerebrais ou sistêmicas. As alterações oculares são raras e as manifestações clínicas, simulando miastenia gravis (MG, não foram descritas até o momento. Descrevemos uma mulher de 23 anos apresentando discreta limitação da movimentação ocular com progressiva ptose palpebral que mudava de intensidade durante o dia. A investigação mostrou negativos o anticorpo anti-receptor de acetilcolina, a estimulação nervosa repetitiva e o "teste do Tensilon", porém a ressonância magnética de crânio revelou DWS com hidrocefalia associada à disgenesia de corpo caloso. As características da doença, manifestações clínicas e patológicas, especialmente a avaliação clínica de anormalidade ocular na suspeita de DWS serão discutidas, incluindo a MG no diagnóstico diferencial.

  5. Estágios imaturos de Spodoptera cosmioides (Walker (Lepidoptera, Noctuidae Immature stages of Spodoptera cosmioides (Walker (Lepidoptera, Noctuidae

    Directory of Open Access Journals (Sweden)

    Maurício M. Zenker

    2007-03-01

    Full Text Available O gênero Spodoptera Guenée, 1852 é composto por trinta espécies de distribuição cosmopolita, encontradas com maior freqüência em locais de clima mais quente. Quinze espécies são pragas agrícolas, apresentando alto grau de polifitofagia, alimentando-se de importantes culturas como soja, milho, arroz e batata inglesa. A morfologia dos estágios imaturos dos representantes deste gênero é pouco conhecida, sendo que um terço das espécies não possui descrição de seus estágios imaturos. Entre as espécies ocorrentes no Brasil, sem tais informações, destaca-se Spodoptera cosmioides (Walker, 1858. Este trabalho caracterizou detalhadamente seus principais aspectos morfológicos, passíveis de serem utilizados na identificação taxonômica dos estágios imaturos; contém dados referentes à morfologia, destacando-se a área micropilar dos ovos, quetotaxia, fiandeira e coloração da fase de lagarta e disposição dos apêndices e aberturas naturais nas pupas.There are 30 species in the genus Spodoptera Guenée, 1852 worldwide distributed, occurring mainly in the warm regions. Fifteen species are considered plagues feeding on several important agricultural crops as soybean, corn, rice and potato. The immature stages morphology of this genus is not well known. In about one third of the most economically relevant species, the caterpillar is not described and, also, few information related to the chrysalis and the eggs are available. Spodoptera cosmioides (Walker, 1858 is one of the most important pest among the noctuids occurring in Brazil with no information about its immature stages. Detailed morphological descriptions and illustrations of the immature stages of S. cosmioides, as micropilar area of the egg, chaetotaxy, spinneret, caterpillar ground color, arrangement of the appendages and natural openings of the pupa, are presented for the first time. Taxonomic remarks are also provided.

  6. New Analytical Solution of the Equilibrium Ampere's Law Using the Walker's Method: a Didactic Example

    Science.gov (United States)

    Sousa, A. N. Laurindo; Ojeda-González, A.; Prestes, A.; Klausner, V.; Caritá, L. A.

    2018-02-01

    This work aims to demonstrate the analytical solution of the Grad-Shafranov (GS) equation or generalized Ampere's law, which is important in the studies of self-consistent 2.5-D solution for current sheet structures. A detailed mathematical development is presented to obtain the generating function as shown by Walker (RSPSA 91, 410, 1915). Therefore, we study the general solution of the GS equation in terms of the Walker's generating function in details without omitting any step. The Walker's generating function g( ζ) is written in a new way as the tangent of an unspecified function K( ζ). In this trend, the general solution of the GS equation is expressed as exp(- 2Ψ) = 4| K '( ζ)|2/cos2[ K( ζ) - K( ζ ∗)]. In order to investigate whether our proposal would simplify the mathematical effort to find new generating functions, we use Harris's solution as a test, in this case K( ζ) = arctan(exp( i ζ)). In summary, one of the article purposes is to present a review of the Harris's solution. In an attempt to find a simplified solution, we propose a new way to write the GS solution using g( ζ) = tan( K( ζ)). We also present a new analytical solution to the equilibrium Ampere's law using g( ζ) = cosh( b ζ), which includes a generalization of the Harris model and presents isolated magnetic islands.

  7. A Linguistic Analysis of Rhetorical Strategies in Selected Narratives of Alice Walker

    Science.gov (United States)

    Matunda, Robert Stephen Mokaya

    2009-01-01

    The objective of this investigation was to analyze rhetorical strategies of Alice Walker in four narratives, namely, "The Color Purple, In Search of Our Mother's Gardens, Possessing the Secret of Joy, and Now Is the Time To Open Your Heart". As such, this study helps to expand the body of investigation relating linguistics to literature and medium…

  8. Hybridization between multi-objective genetic algorithm and support vector machine for feature selection in walker-assisted gait.

    Science.gov (United States)

    Martins, Maria; Costa, Lino; Frizera, Anselmo; Ceres, Ramón; Santos, Cristina

    2014-03-01

    Walker devices are often prescribed incorrectly to patients, leading to the increase of dissatisfaction and occurrence of several problems, such as, discomfort and pain. Thus, it is necessary to objectively evaluate the effects that assisted gait can have on the gait patterns of walker users, comparatively to a non-assisted gait. A gait analysis, focusing on spatiotemporal and kinematics parameters, will be issued for this purpose. However, gait analysis yields redundant information that often is difficult to interpret. This study addresses the problem of selecting the most relevant gait features required to differentiate between assisted and non-assisted gait. For that purpose, it is presented an efficient approach that combines evolutionary techniques, based on genetic algorithms, and support vector machine algorithms, to discriminate differences between assisted and non-assisted gait with a walker with forearm supports. For comparison purposes, other classification algorithms are verified. Results with healthy subjects show that the main differences are characterized by balance and joints excursion in the sagittal plane. These results, confirmed by clinical evidence, allow concluding that this technique is an efficient feature selection approach. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  9. Adjuvant radiation therapy in uterine carcinosarcoma: A population-based analysis of patient demographic and clinical characteristics, patterns of care and outcomes.

    Science.gov (United States)

    Manzerova, Julia; Sison, Cristina P; Gupta, Divya; Holcomb, Kevin; Caputo, Thomas A; Parashar, Bhupesh; Nori, Dattatreyudu; Wernicke, A Gabriella

    2016-05-01

    To examine clinical and demographic characteristics of a population-based cohort of patients with uterine carcinosarcoma (UCS), to assess access to treatment and survival patterns. Surveillance, Epidemiology and End Results database was queried for patients diagnosed in 1999-2010 and treated with surgery with or without adjuvant radiation therapy (aRT). The Kaplan-Meier method was used to estimate survival functions, and Cox proportional hazards regression - to analyze the effect of covariates on survival. 2342 patients were eligible. African Americans presented with more advanced AJCC stages than other races (35.4% vs. 29.1%; pAfrican Americans vs. others, and women diagnosed in 1999-2004 vs. in 2005-2010, received aRT at a similar rate: 36.5% vs. 39.9% (p=NS), and 39.5% vs. 38.9% (p=NS), respectively. There was a trend towards higher aRT utilization among patients younger than 65 vs. older (41.4% vs. 37.5%; paRT group: 42 vs. 22 (paRT group. African Americans were more likely to present with later stage disease and die of UCS than non-African Americans. Age and stage, but not race, influenced receipt of aRT. Patients treated more recently survived longer. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Dissemination of Walker 256 carcinoma cells to rat skeletal muscle

    International Nuclear Information System (INIS)

    Ueoka, H.; Hayashi, K.; Namba, T.; Grob, D.

    1986-01-01

    After injection of 10 6 Walker 256 carcinoma cells labelled with 125 I-5-iodo-2'-deoxyuridine into the tail vein, peak concentration in skeletal muscle was 46 cells/g at 60 minutes, which was lower than 169202, 1665, 555, 198 and 133 cells/g, respectively, at 30 or 60 minutes in lung, liver, spleen, kidney and heart. Because skeletal muscle constitutes 37.4% of body weight, the total number of tumor cells was 2323 cells, which was much greater than in spleen, kidney and heart with 238, 271, and 85 cells, respectively, and only less than in lung and liver, at 222857 and 11700 cells, respectively. The total number in skeletal muscle became greater than in liver at 4 hours and than in lung at 24 hours. Ten minutes after injection of 7.5 x 10 6 Walker 256 carcinoma cells into the abdominal aorta of rats, a mean of 31 colony-forming cells were recovered from the gastrocnemius, while 106 cells were recovered from the lung after injection into the tail vein. These results indicate that a large number of viable tumor cells can be arrested in skeletal muscle through circulation. The rare remote metastasis of malignancies into skeletal muscle despite constantly circulating tumor cells does not appear to be due to poor dissemination of tumor cells into muscle but due to unhospitable environment of skeletal muscle

  11. ACADEMIC TRAINING (R.P. Walker)

    CERN Multimedia

    Françoise Benz

    2002-01-01

    15, 16, 17 May LECTURE SERIES from 11.00 to 12.00 hrs - Council room, bldg. 503 on 15 May, Auditorium, bldg. 500 on 16 and 17 May Introduction to free electron lasers by R.P. Walker / Rutherford Laboratory, UK The Free-electron laser (FEL) is a source of coherent electromagnetic radiation based on a relativistic electron beam. First operated 25 years ago, the FEL has now reached a stage of maturity for operation in the infra-red region of the spectrum and several facilities provide intense FEL radiation beams for research covering a wide range of disciplines. Several projects both underway and proposed aim at pushing the minimum wavelength from its present limit around 100 nm progressively down to the 1 Angstrom region where the X-ray FEL would open up many new and exciting research possibilities. Other developments aim at increasing power levels to the 10's of kW level. In this series of lectures we give an introduction to the basic principles of FELs and their different modes of operation, and summarise the...

  12. Sex Differences in Moral Reasoning: Response to Walker's (1984) Conclusion That There Are None.

    Science.gov (United States)

    Baumrind, Diana

    1986-01-01

    Takes issue with Lawrence Walker's literature review on developmental and individual differences in moral reasoning which found no consistent evidence for sex differences in moral development. Argues instead that the source and specific nature of these differences have yet to be established. (HOD)

  13. Green's functions for a scalar fields in a class of Robertson-Walker space-times

    International Nuclear Information System (INIS)

    Mankin, Romi; Ainsaar, Ain

    1997-01-01

    The retarded and advanced Green's functions for a massless non conformally-coupled scalar field in a class of Robertson-Walker space-times are calculated analytically. The results are applied to the calculation of the Hadamard fundamental solutions in some special cases. (author)

  14. Walker occupancy has an impact on changing airborne bacterial communities in an underground pedestrian space, as small-dust particles increased with raising both temperature and humidity.

    Science.gov (United States)

    Okubo, Torahiko; Osaki, Takako; Nozaki, Eriko; Uemura, Akira; Sakai, Kouhei; Matushita, Mizue; Matsuo, Junji; Nakamura, Shinji; Kamiya, Shigeru; Yamaguchi, Hiroyuki

    2017-01-01

    Although human occupancy is a source of airborne bacteria, the role of walkers on bacterial communities in built environments is poorly understood. Therefore, we visualized the impact of walker occupancy combined with other factors (temperature, humidity, atmospheric pressure, dust particles) on airborne bacterial features in the Sapporo underground pedestrian space in Sapporo, Japan. Air samples (n = 18; 4,800L/each sample) were collected at 8:00 h to 20:00 h on 3 days (regular sampling) and at early morning / late night (5:50 h to 7:50 h / 22:15 h to 24:45 h) on a day (baseline sampling), and the number of CFUs (colony forming units) OTUs (operational taxonomic units) and other factors were determined. The results revealed that temperature, humidity, and atmospheric pressure changed with weather. The number of walkers increased greatly in the morning and evening on each regular sampling day, although total walker numbers did not differ significantly among regular sampling days. A slight increase in small dust particles (0.3-0.5μm) was observed on the days with higher temperature regardless of regular or baseline sampling. At the period on regular sampling, CFU levels varied irregularly among days, and the OTUs of 22-phylum types were observed, with the majority being from Firmicutes or Proteobacteria (γ-), including Staphylococcus sp. derived from human individuals. The data obtained from regular samplings reveled that although no direct interaction of walker occupancy and airborne CFU and OTU features was observed upon Pearson's correlation analysis, cluster analysis indicated an obvious lineage consisting of walker occupancy, CFU numbers, OTU types, small dust particles, and seasonal factors (including temperature and humidity). Meanwhile, at the period on baseline sampling both walker and CFU numbers were similarly minimal. Taken together, the results revealed a positive correlation of walker occupancy with airborne bacteria that increased with increases in

  15. Solutions to the maximal spacelike hypersurface equation in generalized Robertson-Walker spacetimes

    Directory of Open Access Journals (Sweden)

    Henrique F. de Lima

    2018-03-01

    Full Text Available We apply some generalized maximum principles for establishing uniqueness and nonexistence results concerning maximal spacelike hypersurfaces immersed in a generalized Robertson-Walker (GRW spacetime, which is supposed to obey the so-called timelike convergence condition (TCC. As application, we study the uniqueness and nonexistence of entire solutions of a suitable maximal spacelike hypersurface equation in GRW spacetimes obeying the TCC.

  16. Public and private space curvature in Robertson-Walker universes.

    Science.gov (United States)

    Rindler, W.

    1981-05-01

    The question is asked: what space curvature would a fundamental observer in an ideal Robertson-Walker universe obtain by direct local spatial measurements, i.e., without reference to the motion pattern of the other galaxies? The answer is that he obtains the curvatureK of his “private” space generated by all the geodesics orthogonal to his world line at the moment in question, and that ˜K is related to the usual curvatureK=k/R 2 of the “public” space of galaxies byK=K+H 2/c2, whereH is Hubble's parameter.

  17. Inverse curvature flows in asymptotically Robertson Walker spaces

    Science.gov (United States)

    Kröner, Heiko

    2018-04-01

    In this paper we consider inverse curvature flows in a Lorentzian manifold N which is the topological product of the real numbers with a closed Riemannian manifold and equipped with a Lorentzian metric having a future singularity so that N is asymptotically Robertson Walker. The flow speeds are future directed and given by 1 / F where F is a homogeneous degree one curvature function of class (K*) of the principal curvatures, i.e. the n-th root of the Gauss curvature. We prove longtime existence of these flows and that the flow hypersurfaces converge to smooth functions when they are rescaled with a proper factor which results from the asymptotics of the metric.

  18. Field screening of water quality, bottom sediment, and biota associated with irrigation drainage in and near Walker River Indian Reservation, Nevada 1994-95

    Science.gov (United States)

    Thodal, Carl E.; Tuttle, Peter L.

    1996-01-01

    A study was begun in 1994 to determine whether the quality of irrigation drainage from the Walker River Indian Reservation, Nevada, has caused or has potential to cause harmful effects on human health or on fish and wildlife, or may adversely affect the suitability of the Walker River for other beneficial uses. Samples of water, bottom sediment, and biota were collected during June-August 1994 (during a drought year) from sites upstream from and on the Walker River Indian Reservation for analyses of trace elements. Other analyses included physical characteristics, major dissolved constituents, selected species of water-soluble nitrogen and phosphorus, and selected pesticides in bottom sediment. Water samples were collected again from four sites on the Reservation in August 1995 (during a wetterthan- average year) to provide data for comparing extreme climatic conditions. Water samples collected from the Walker River Indian Reservation in 1994 equaled or exceeded the Nevada water-quality standard or level of concern for at least one of the following: water temperature, pH, dissolved solids, unionized ammonia, phosphate, arsenic, boron, chromium, lead, and molybdenum; in 1995, only a single sample from one site exceeded a Nevada water-quality standard for molybdenum. Levels of concern for trace elements in bottom sediment collected in 1994 were equaled or exceeded for arsenic, iron, manganese, and zinc. Concentrations of organochiorine pesticide residues in bottom sediment were below analytical reporting limits. Levels of concern for trace-elements in samples of biota were equaled or exceeded for arsenic, boron, copper, and mercury. Results of toxicity testing indicate that only water samples from Walker Lake caused a toxic response in test bacteria. Arsenic and boron concentrations in water, bottom sediment, and biological tissue exceeded levels of concern throughout the Walker River Basin, but most commonly in the lower Walker River Basin. Mercury also was elevated

  19. The Legal Dimension of RTI--Confusion Confirmed: A Response to Walker and Daves

    Science.gov (United States)

    Zirkel, Perry A.

    2012-01-01

    In this issue of "Learning Disability Quarterly" (LDQ), Professors Daves and Walker reply to my earlier LDQ article on confusion in the cases and commentary about the legal dimension of RTI. In this brief rejoinder, I show that their reply confirms rather than resolves the confusion in their original commentary in 2010. This persistent…

  20. Dandy Walker Syndrome with Unusual Associated Findings in a Fetal Autopsy Study

    OpenAIRE

    Surekha U Arakeri; Himanshu Mulay

    2015-01-01

    Dandy Walker Syndrome (DWS) is a congenital brain malformation characterized by hypoplasia or absence of cerebellar vermis, cystic dilatation of fourth ventricle and hydrocephalus. It is frequently associated with other congenital anomalies. Associated central nervous system anomalies such as agenesis of corpus callosum and vermis are associated with poor prognosis. Association of DWS with congenital absence of spleen is life threatening condition and has been reported...

  1. A preliminary study of murine walker-256 tumor hypoxia detected by blood oxygen level dependent-MR

    International Nuclear Information System (INIS)

    Zhang Shengjian; Mao Jian; Wu Bin; Peng Weijun

    2013-01-01

    Objective: To establish Walker-256 transplantation tumor model in SD Rats. To study of R_2"* signal changes on murine Walker-256 tumor after inhaling Carbogen by blood oxygen level dependent (BOLD)-MR, and to explore the feasibility of BOLD-MRI on detecting tumor hypoxia. Methods: Walker-256 tumor cell implanted subcutaneously in right lower abdomen of 95 female SD rats. MR was performed on the tumor-forming rats when the maximum diameter of tumor reached 1-3 cm, using a 3.0 T MR scanner equipped with a 3 inch animal surface coil. BOLD-MRI was done by using a multiecho SPGR sequence during inhaling air and at 10 minute after inhaling Carbogen, respectively. All images were transferred to GE ADW 4.3 workstation, then a baseline R_2"* (R_2"* a) and R_2"* (R_2"* b) after inhaling Carbogen of tumor was calculated using R_2 Star analysis software and ΔR_2"* was calculated through ΔR_2"* = R_2"* b -R_2"* a", meanwhile the volume of tumor were calculated as well. The difference of R_2"* signal pre and post-inhaling of Carbogen was compared with a paired t test, Pearson correlation was calculated between R_2"* a, ΔR_2"* and the volume of tumor, respectively. The correlation between ΔR_2"* and R_2"* a was also assessed by Pearson correlation. Results: Sixty-eight of ninety-five female SD rats formed the tumor (71.6%). The volume of tumor was from 352 to 13 173 mm"3. Mean ΔR_2"* decreased significantly (-2.26 ± 3.90) s"-"1 from (41.18 ± 22.29) s"-"1 during breathing air to (38.91 ± 21.35) s"-"1 10 min after inhaling Carbogen (t = 4.01, P 0.05). Conclusions: BOLD-MRI can detect the R_2"* signal change of murine Walker-256 tumor pre-and post-inhaling of Carbogen. The R_2"* signal showed significant decrease after inhaling Carbogen, however, the individual variation was remarkable. (authors)

  2. Grain-size data from four cores from Walker Lake, Nevada

    International Nuclear Information System (INIS)

    Yount, J.C.; Quimby, M.F.

    1990-01-01

    A number of cores, taken from within and near Walker Lake, Nevada are being studied by various investigators in order to evaluate the late-Pleistocene paleoclimate of the west-central Great Basin. In particular, the cores provide records that can be interpreted in terms of past climate and compared to proposed numerical models of the region's climate. All of these studies are being carried out as part of an evaluation of the regional paleoclimatic setting of a proposed high-level nuclear waste storage facility at Yucca Mountain, Nevada. Changes in past climate often manifest themselves in changes in sedimentary processes or in changes in the volume of sediment transported by those processes. One fundamental sediment property that can be related to depositional processes is grain size. Grain size effects other physical properties of sediment such as porosity and permeability which, in turn, affect the movement and chemistry of fluids. The purposes of this report are: (1) to document procedures of sample preparation and analysis, and (2) to summarize grain-size statistics for 659 samples from Walker Lake cores 84-4, 84-5, 84-8 and 85-2. Plots of mean particle diameter, percent sand, and the ratio of silt to clay are illustrated for various depth intervals within each core. Summary plots of mean grain size, sorting, and skewness parameters allow comparison of textural data between each core. 15 refs., 8 figs., 3 tabs

  3. Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers

    Science.gov (United States)

    Ross, Megan L.; Garvican‐Lewis, Laura A.; Welvaert, Marijke; Heikura, Ida A.; Forbes, Sara G.; Mirtschin, Joanne G.; Cato, Louise E.; Strobel, Nicki; Sharma, Avish P.; Hawley, John A.

    2017-01-01

    Key points Three weeks of intensified training and mild energy deficit in elite race walkers increases peak aerobic capacity independent of dietary support.Adaptation to a ketogenic low carbohydrate, high fat (LCHF) diet markedly increases rates of whole‐body fat oxidation during exercise in race walkers over a range of exercise intensities.The increased rates of fat oxidation result in reduced economy (increased oxygen demand for a given speed) at velocities that translate to real‐life race performance in elite race walkers.In contrast to training with diets providing chronic or periodised high carbohydrate availability, adaptation to an LCHF diet impairs performance in elite endurance athletes despite a significant improvement in peak aerobic capacity. Abstract We investigated the effects of adaptation to a ketogenic low carbohydrate (CHO), high fat diet (LCHF) during 3 weeks of intensified training on metabolism and performance of world‐class endurance athletes. We controlled three isoenergetic diets in elite race walkers: high CHO availability (g kg−1 day−1: 8.6 CHO, 2.1 protein, 1.2 fat) consumed before, during and after training (HCHO, n = 9); identical macronutrient intake, periodised within or between days to alternate between low and high CHO availability (PCHO, n = 10); LCHF (diets providing chronic or periodised high‐CHO availability, and despite a significant improvement in V˙O2 peak , adaptation to the topical LCHF diet negated performance benefits in elite endurance athletes, in part due to reduced exercise economy. PMID:28012184

  4. If the Song Sounds the Same Check for Static: A Reply to Walker and Frimer

    Science.gov (United States)

    Sherblom, Stephen A.

    2009-01-01

    The "care challenge" is shown to be both broader and more successful than Walker and Frimer's (this issue, pp. 53-68) critique allows. The main philosophical and psychological tenets of the care challenge foreshadowed the direction of twenty-first century moral psychology.

  5. A review of the New World Atteva Walker moths (Yponomeutidae, Attevinae Resenha das mariposas do gênero Atteva Walker do Novo Mundo (Yponomeutidae, Attevinae

    Directory of Open Access Journals (Sweden)

    Vitor O. Becker

    2009-01-01

    Full Text Available The New World species of Atteva Walker are reviewed and illustrated in colour. One name: A. pustulella (Fabricius, nom. rev. and three species: A. aurea (Fitch, sp. rev., A. floridana (Neumoegen, sp. rev. and A. gemmata (Grote, sp. rev. are reinstated; five names are synonymised under A. aurea: Poeciloptera compta Clemens, syn. n., A. edithella Busck, syn. n., A. exquisita Busck, syn. n., A. ergatica Walsingham, syn. n. and A. microsticta Walsingham, syn. n.; four new species are described: A. rawlinsi sp. n., from the Dominican Republic, A. sidereoides sp. n., from Jamaica, A. entermedia sp. n., from Antigua, and A. zebrina sp. n., from Brazil; lectotypes for A. floridana and A. glaucopidella (Guenée (=fulviguttata are also designated.As species de Atteva Walker são revistas e ilustradas em cores. Um nome: A. pustulella (Fabricius, nom. rev. e três espécies: A. aurea (Fitch, sp. rev., A. floridana (Neumoegen, sp. rev. and A. gemmata (Grote, sp. rev. são restabelecidos; cinco nomes são considerados sinônimos recentes de A.aurea: Poeciloptera compta Clemens, syn. n., A. edithella Busck, syn. n., A. exquisita Busck, syn. n., A. ergatica Walsingham, syn. n. e A. microsticta Walsingham, syn. n.; quatro espécies novas são descritas: A. rawlinsi sp. n., da República Dominica, A. sidereoides sp. n., da Jamaica, A. entermedia sp. n., de Antigua, e A. zebrina sp. n., do Brazil; são designados lectótipos para A. floridana e A. glaucopidella (Guenée (=fulviguttata.

  6. Thomas James Walker (1835-1916): Surgeon and general practitioner.

    Science.gov (United States)

    Thomas, Martyn

    2018-02-01

    Thomas James Walker was a surgeon and general practitioner who worked in the city of Peterborough at a time when there were changes and innovations in the practice of medicine. After training in medicine and surgery at Edinburgh University, he qualified in London in 1857. He was a pioneer of laryngoscopy. He played an important role in introducing antiseptic surgery to the Peterborough Infirmary and was instrumental in the development of the operating theatre which opened in 1894. He was a philanthropist and collector of Roman and Saxon artefacts. In 1915, he was recognized as an outstanding member of the Peterborough community when he was offered the Freedom of the City.

  7. The navel orangeworm, Amyelois transtilla (Walker) (Lepidoptera: Pyralidae) discovered in northeastern Mexico feeding on Sapindaceae

    Science.gov (United States)

    Amyelois transitella (Walker) (Lepidoptera: Pyralidae), the navel orangeworm, is an important pest of a wide variety fruits and their seeds. We discovered and report for the first time A. transitella feeding on Sapindaceae in wild populations of U. speciosa (Endl.) in northeastern Mexico. We provid...

  8. Precipitation Change and Soil Leaching: Field Results and Simulations from Walker Branch Watershed, Tennessee

    Science.gov (United States)

    D.W. Johnson; P.J. Hanson; D.E. Todd; R.B. Susfalk; Carl C. Trettin

    1998-01-01

    Abstract. To investigate the potential effects of changing precipitation on a deciduous forest ecosystem, an experiment was established on Walker Branch Watershed, Tennessee that modified the amount of throughfall at 4 -33 %. ambient (no change), and +33 % using a system of rain gutters and sprinklers. We hypothesized that the drier treatments would...

  9. Beyond the Friedmann—Lemaître—Robertson—Walker Big Bang Singularity

    International Nuclear Information System (INIS)

    Stoica, Cristi

    2012-01-01

    Einstein's equation, in its standard form, breaks down at the Big Bang singularity. A new version, equivalent to Einstein's whenever the latter is defined, but applicable in wider situations, is proposed. The new equation remains smooth at the Big Bang singularity of the Friedmann—Lemaître—Robertson—Walker model. It is a tensor equation defined in terms of the Ricci part of the Riemann curvature. It is obtained by taking the Kulkarni—Nomizu product between Einstein's equation and the metric tensor.

  10. Automatic detection of lift-off and touch-down of a pick-up walker using 3D kinematics.

    Science.gov (United States)

    Grootveld, L; Thies, S B; Ogden, D; Howard, D; Kenney, L P J

    2014-02-01

    Walking aids have been associated with falls and it is believed that incorrect use limits their usefulness. Measures are therefore needed that characterize their stable use and the classification of key events in walking aid movement is the first step in their development. This study presents an automated algorithm for detection of lift-off (LO) and touch-down (TD) events of a pick-up walker. For algorithm design and initial testing, a single user performed trials for which the four individual walker feet lifted off the ground and touched down again in various sequences, and for different amounts of frame loading (Dataset_1). For further validation, ten healthy young subjects walked with the pick-up walker on flat ground (Dataset_2a) and on a narrow beam (Dataset_2b), to challenge balance. One 88-year-old walking frame user was also assessed. Kinematic data were collected with a 3D optoelectronic camera system. The algorithm detected over 93% of events (Dataset_1), and 95% and 92% in Dataset_2a and b, respectively. Of the various LO/TD sequences, those associated with natural progression resulted in up to 100% correctly identified events. For the 88-year-old walking frame user, 96% of LO events and 93% of TD events were detected, demonstrating the potential of the approach. Copyright © 2013 IPEM. Published by Elsevier Ltd. All rights reserved.

  11. Creatine supplementation prevents hyperhomocysteinemia, oxidative stress and cancer-induced cachexia progression in Walker-256 tumor-bearing rats.

    Science.gov (United States)

    Deminice, Rafael; Cella, Paola Sanches; Padilha, Camila S; Borges, Fernando H; da Silva, Lilian Eslaine Costa Mendes; Campos-Ferraz, Patrícia L; Jordao, Alceu Afonso; Robinson, Jason Lorne; Bertolo, Robert F; Cecchini, Rubens; Guarnier, Flávia Alessandra

    2016-08-01

    The purpose of this study was to investigate (1) the impact of tumor growth on homocysteine (Hcy) metabolism, liver oxidative stress and cancer cachexia and, (2) the potential benefits of creatine supplementation in Walker-256 tumor-bearing rats. Three experiments were conducted. First, rats were killed on days 5 (D5), 10 (D10) and 14 (D14) after tumor implantation. In experiment 2, rats were randomly assigned to three groups designated as control (C), tumor-bearing (T) and tumor-bearing supplemented with creatine (TCr). A life span experiment was conducted as the third experiment. Creatine was supplied in drinking water for 21 days (8 g/L) in all cases. Tumor implantation consisted of a suspension of Walker-256 cells (8.0 × 10(7) cells in 0.5 mL of PBS). The progressive increase (P creatine supplementation promoted a 28 % reduction of tumor weight (P Creatine supplementation was unable to decrease Hcy concentration and to increase SAM/SAH ratio in tumor tissue. These data suggest that creatine effects on hepatic impaired Hcy metabolism promoted by tumor cell inoculation are responsible to decrease plasma Hcy in tumor-bearing rats. In conclusion, Walker-256 tumor growth is associated with progressive hyperhomocysteinemia, body weight loss and liver oxidative stress in rats. Creatine supplementation, however, prevented these tumor-associated perturbations.

  12. Anestesia em criança com síndrome de Walker-Warburg

    Directory of Open Access Journals (Sweden)

    Emine Arzu Kose

    2014-04-01

    Full Text Available Justificativa e objetivos: A síndrome de Walker-Warburg é uma distrofia muscular autossômica recessiva congênita rara, manifestada pelo sistema nervoso central com malformações oculares e possível envolvimento de vários sistemas. O diagnóstico é estabelecido pela presença de quatro critérios: distrofia muscular congênita, lisencefalia tipo II, malformação cerebelar e malformação da retina. A maioria das crianças com a síndrome morre nos primeiros três anos de vida por causa de insuficiência respiratória, pneumonia, convulsões, hipertermia e fibrilação ventricular. Relato de caso: É discutida a conduta anestésica em uma criança do sexo masculino, de dois meses, programada para cirurgia eletiva de derivação ventrículo-peritoneal. Conclusões: Uma abordagem anestésica cuidadosa é necessária por causa do envolvimento de vários sistemas. Relatamos a conduta anestésica em uma criança do sexo masculino de dois meses com síndrome de Walker-Warburg, que foi programada para cirurgia eletiva de derivação ventrículo-peritoneal.

  13. Climatic changes inferred fron analyses of lake-sediment cores, Walker Lake, Nevada

    International Nuclear Information System (INIS)

    Yang, In Che.

    1989-01-01

    Organic and inorganic fractions of sediment collected from the bottom of Walker Lake, Nevada, have been dated by carbon-14 techniques. Sedimentation rates and the organic-carbon content of the sediment were correlated with climatic change. The cold climate between 25,000 and 21,000 years ago caused little runoff, snow accumulation on the mountains, and rapid substantial glacial advances; this period of cold climate resulted in a slow sedimentation rate (0.20 millimeter per year) and in a small organic-carbon content in the sediment. Also, organic-carbon accumulation rates in the lake during this period were slow. The most recent period of slow sedimentation rate and small organic-carbon content occurred between 10,000 and 5500 years ago, indicative of low lake stage and dry climatic conditions. This period of dry climate also was evidenced by dry conditions for Lake Lahontan in Nevada and Searles Lake in California, as cited in the literature. Walker Lake filled rapidly with water between 5500 and 4500 years ago. The data published in this report was not produced under an approved Site Investigation Plan (SIP) or Study Plan (SP) and will not be used in the licensing process. 10 refs., 3 figs., 2 tabs

  14. Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats

    Directory of Open Access Journals (Sweden)

    Camila Oliveira de Souza

    2015-07-01

    Full Text Available Background/Aims: The main purpose of this study was to investigate the effects of celecoxib and ibuprofen, both non-steroidal anti-inflammatory drugs (NSAIDs, on the decreased gluconeogenesis observed in liver of Walker-256 tumor-bearing rats. Methods: Celecoxib and ibuprofen (both at 25 mg/Kg were orally administered for 12 days, beginning on the same day when the rats were inoculated with Walker-256 tumor cells. Results: Celecoxib and ibuprofen treatment reversed the reduced production of glucose, pyruvate, lactate and urea from alanine as well as the reduced production of glucose from pyruvate and lactate in perfused liver from tumor-bearing rats. Besides, celecoxib and ibuprofen treatment restored the decreased ATP content, increased triacylglycerol levels and reduced mRNA expression of carnitine palmitoyl transferase 1 (CPT1, while ibuprofen treatment restored the reduced mRNA expression of peroxisome proliferator-activated receptor alpha (PPARα in the liver of tumor-bearing rats. Both treatments tended to decrease TNFα, IL6 and IL10 in the liver of tumor-bearing rats. Finally, the treatment with celecoxib, but not with ibuprofen, reduced the growth of Walker-256 tumor. Conclusion: Celecoxib and ibuprofen restored the decreased gluconeogenesis in the liver of Walker-256 tumor-bearing rats. These effects did not involve changes in tumor growth and probably occurred by anti-inflammatory properties of these NSAIDs, which increased expression of genes associated with fatty acid oxidation (PPARα and CPT1 and consequently the ATP production, normalizing the energy status in the liver of tumor-bearing rats.

  15. Determining the Walker exponent and developing a modified Smith-Watson-Topper parameter model

    Energy Technology Data Exchange (ETDEWEB)

    Lv, Zhiqiang; Huang, Hong Zhong; Wang, Hai Kun; Gao, Huiying; Zuo, Fang Jun [University of Electronic Science and Technology of China, Chengdu (China)

    2016-03-15

    Mean stress effects significantly influence the fatigue life of components. In general, tensile mean stresses are known to reduce the fatigue life of components, whereas compressive mean stresses are known to increase it. To date, various methods that account for mean stress effects have been studied. In this research, considering the high accuracy of mean stress correction and the difficulty in obtaining the material parameter of the Walker method, a practical method is proposed to describe the material parameter of this method. The test data of various materials are then used to verify the proposed practical method. Furthermore, by applying the Walker material parameter and the Smith-Watson-Topper (SWT) parameter, a modified strain-life model is developed to consider sensitivity to mean stress of materials. In addition, three sets of experimental fatigue data from super alloy GH4133, aluminum alloy 7075-T651, and carbon steel are used to estimate the accuracy of the proposed model. A comparison is also made between the SWT parameter method and the proposed strainlife model. The proposed strain-life model provides more accurate life prediction results than the SWT parameter method.

  16. Quantum field theory in flat Robertson-Walker space-time functional Schrodinger picture

    International Nuclear Information System (INIS)

    Pi, S.Y.

    1990-01-01

    Quantum field theory in Robertson-Walker space-time is intrinsically time-dependent and the functional Schrodinger picture provides a useful description. This paper discusses free and self-interacting bosonic quantum field theories: Schrodinger picture quantization, time-dependent Gaussian approximations based on variational principles describing time evolution of pure and mixed states, and renormalizability of the Schrodinger picture. The technique introduced can be used to study various dynamical questions in early universe processes

  17. Quantum field theory in flat Robertson-Walker space-time functional Schroedinger picture

    International Nuclear Information System (INIS)

    Pi, S.Y.

    1989-01-01

    Quantum field theory in Robertson-Walker space-time is intrinsically time-dependent and the functional Schroedinger picture provides a useful description. We discuss free and self-interacting bosonic quantum field theories: Schroedinger picture quantization, time-dependent Gaussian approximations based on variational principles describing time evolution of pure and mixed states, and renormalizability of the Schroedinger picture. The techniques introduced can be used to study various dynamical questions in early universe processes. (author)

  18. Beliefs about the use of baby walkers Crenças sobre o uso do andador infantil

    Directory of Open Access Journals (Sweden)

    Paula S. C. Chagas

    2011-08-01

    Full Text Available OBJECTIVES: To understand the opinion of the parents about the baby walker and compare the age of gait acquisition between infants that used a walker and those that did not. METHODS: In this quali-quantitative study, an interview involving a semi-structured questionnaire was carried out with 26 parents, 14 of whose infants used the equipment (BWG and 12 of whose infants did not (NBWG prior to gait acquisition. After extensive content analysis, categories for interpreting the results emerged. For data triangulation, the age of gait acquisition was documented by weekly telephone contact. Student's t-test was used for comparison between groups with a significance level of α=0.05. RESULTS: The following categories were identified in the parents' reports: a information about the baby walker; b doubt/decision to use it vs. certainty about not using it; c beliefs about the use of a baby-walker; and d benefits and harm from use. The age of independent gait acquisition did not differ between groups (p=0.837: BWG initiated gait at 376.17 (SD=32.62 days and NBWG did so at 378.75 (SD=27.99 days. CONCLUSIONS: The beliefs and feelings that permeate the decision to use a baby walker illustrate the different rationales adopted by parents about the role of this equipment in the child's development of gait and autonomy. The use of a baby walker did not influence the age of gait acquisition. The results broaden the understanding of choices that influence child-rearing practices prior to gait acquisition.OBJETIVOS: Conhecer a opinião dos pais sobre o uso do andador infantil e comparar a idade de aquisição da marcha independente entre os lactentes que usaram e os que não usaram o andador. MÉTODOS: Neste estudo qualiquantitativo, realizou-se entrevista com questionário semiestruturado com 26 pais, 14 de lactentes que usaram (GUAI e 12 dos que não usaram o equipamento (GNUAI antes da aquisição da marcha. Empregou-se análise de conteúdo, a partir da qual

  19. Conformal Killing vectors in Robertson-Walker spacetimes

    International Nuclear Information System (INIS)

    Maartens, R.; Maharaj, S.d.

    1986-01-01

    It is well known that Robertson-Walker spacetimes admit a conformal Killingl vector normal to the spacelike homogeneous hypersurfaces. Because these spacetimes are conformally flat, there are a further eight conformal Killing vectors, which are neither normal nor tangent to the homogeneous hypersurfaces. The authors find these further conformal Killing vectors and the Lie algebra of the full G 15 of conformal motions. Conditions on the metric scale factor are determined which reduce some of the conformal Killing vectors to homothetic Killing vectors or Killing vectors, allowing one to regain in a unified way the known special geometries. The non-normal conformal Killing vectors provide a counter-example to show that conformal motions do not, in general, map a fluid flow conformally. These non-normal vectors are also used to find the general solution of the null geodesic equation and photon Liouville equation. (author)

  20. Comparative study of two female African-American Writers in 20 Centu-ry-Alice Walker VS. Toni Morriso

    Institute of Scientific and Technical Information of China (English)

    桂生义

    2013-01-01

    Toni Morrison and Alice Walker are among the most outstanding female African-American writers in Contemporary American Literature. Their works have been popular since 1960s to now. Although Walker and Morrison grew up under differ⁃ent family environments, they had the same experience of witnessing African-American women’s movements in last Century;therefore, they reached an agreement on writing thoughts and contents. For instance, they both referred to Racism, Sexism and“Womanism”in many of their works. This dissertation studies about the two authors’difference and sameness descriptions on Af⁃rican-American women’s identities, social status, rights, powers and fates,and to express their self-consciousness and bright prospection after experiencing the most painful encounters through comparative study on two of their short stories—Everyday Use and Recitatif.

  1. On the spectrum of particles created in a Robertson-Walker universe

    International Nuclear Information System (INIS)

    Azuma, T.

    1983-01-01

    Created particle spectra are calculated in Robertson-Walker universes and discussed with a special emphasis on their dependence upon the initial and final times at which a WKB-like positive frequency conditions should be imposed. It is shown that the obtained spectra are very sensitive to these times if the WKB approximation for the field equation is not valid in their neighborhood. It is also shown that the total number density of created particles remains finite if the final time is set to be finite. (author)

  2. Multiple phases and vicious walkers in a wedge

    Directory of Open Access Journals (Sweden)

    Gesualdo Delfino

    2015-12-01

    Full Text Available We consider a statistical system in a planar wedge, for values of the bulk parameters corresponding to a first order phase transition and with boundary conditions inducing phase separation. Our previous exact field theoretical solution for the case of a single interface is extended to a class of systems, including the Blume–Capel model as the simplest representative, allowing for the appearance of an intermediate layer of a third phase. We show that the interfaces separating the different phases behave as trajectories of vicious walkers, and determine their passage probabilities. We also show how the theory leads to a remarkable form of wedge covariance, i.e. a relation between properties in the wedge and in the half plane, which involves the appearance of self-Fourier functions.

  3. Computation of Partially Invariant Solutions for the Einstein Walker Manifolds' Identifying Equations

    OpenAIRE

    Nadjafikhah, Mehdi; Jafari, Mehdi

    2014-01-01

    In this paper, partially invariant solutions (PISs) method is applied in order to obtain new four-dimensional Einstein Walker manifolds. This method is based on subgroup classification for the symmetry group of partial differential equations (PDEs) and can be regarded as the generalization of the similarity reduction method. For this purpose, those cases of PISs which have the defect structure delta=1 and are resulted from two-dimensional subalgebras are considered in the present paper. Also ...

  4. Walker devices and microswitch technology to enhance assisted indoor ambulation by persons with multiple disabilities: three single-case studies.

    Science.gov (United States)

    Lancioni, Giulio E; Singh, Nirbhay N; O'Reilly, Mark F; Sigafoos, Jeff; Oliva, Doretta; Campodonico, Francesca; Buono, Serafino

    2013-07-01

    These three single-case studies assessed the use of walker devices and microswitch technology for promoting ambulation behavior among persons with multiple disabilities. The walker devices were equipped with support and weight lifting features. The microswitch technology ensured that brief stimulation followed the participants' ambulation responses. The participants were two children (i.e., Study I and Study II) and one man (i.e., Study III) with poor ambulation performance. The ambulation efforts of the child in Study I involved regular steps, while those of the child in Study II involved pushing responses (i.e., he pushed himself forward with both feet while sitting on the walker's saddle). The man involved in Study III combined his poor ambulation performance with problem behavior, such as shouting or slapping his face. The results were positive for all three participants. The first two participants had a large increase in the number of steps/pushes performed during the ambulation events provided and in the percentages of those events that they completed independently. The third participant improved his ambulation performance as well as his general behavior (i.e., had a decline in problem behavior and an increase in indices of happiness). The wide-ranging implications of the results are discussed. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Diagnosis of Van den Ende-Gupta syndrome: Approach to the Marden-Walker-like spectrum of disorders.

    Science.gov (United States)

    Niederhoffer, Karen Y; Fahiminiya, Somayyeh; Eydoux, Patrice; Mawson, John; Nishimura, Gen; Jerome-Majewska, Loydie A; Patel, Millan S

    2016-09-01

    Marden-Walker syndrome is challenging to diagnose, as there is significant overlap with other multi-system congenital contracture syndromes including Beals congenital contractural arachnodactyly, D4ST1-Deficient Ehlers-Danlos syndrome (adducted thumb-clubfoot syndrome), Schwartz-Jampel syndrome, Freeman-Sheldon syndrome, Cerebro-oculo-facio-skeletal syndrome, and Van den Ende-Gupta syndrome. We discuss this differential diagnosis in the context of a boy from a consanguineous union with Van den Ende-Gupta syndrome, a diagnosis initially confused by the atypical presence of intellectual disability. SNP microarray and whole exome sequencing identified a homozygous frameshift mutation (p.L870V) in SCARF2 and predicted damaging mutations in several genes, most notably DGCR2 (p.P75L) and NCAM2 (p.S147G), both possible candidates for this child's intellectual disability. We review distinguishing features for each Marden-Walker-like syndrome and propose a clinical algorithm for diagnosis among this spectrum of disorders. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  6. The influence of septal lesions on sodium and water retention induced by Walker 256 tumor

    Directory of Open Access Journals (Sweden)

    F. Guimarães

    1999-03-01

    Full Text Available In the course of studies on the effects of septal area lesions on neuroimmunomodulation and Walker 256 tumor development, it was observed that tumor-induced sodium and water retention was less marked in lesioned than in non-lesioned rats. In the present study possible mechanisms involved in this phenomenon were investigated. The experiments were performed in septal-lesioned (LW; N = 15 and sham-operated (SW; N = 7 8-week-old male Wistar rats, which received multifocal simultaneous subcutaneous (sc inoculations of Walker 256 tumor cells about 30 days after the stereotaxic surgery. Control groups (no tumor, sham-operated food-restricted (SFR, N = 7 and lesioned food-restricted (LFR, N = 10 were subjected to a feeding pattern similar to that observed in tumor-bearing animals. Multifocal inoculation of Walker 256 tumor rapidly induces anorexia, which is paradoxically accompanied by an increase in body weight, as a result of renal Na+ and fluid retention. These effects of the tumor were also seen in LW rats, although the rise in fractional sodium balance during the early clinical period was significantly smaller than in SW rats (day 4: SW = 47.6 ± 6.4% and LW = 13.8 ± 5.2%; day 5: SW = 57.5 ± 3.5% and LW = 25.7 ± 4.8%; day 6: SW = 54.4 ± 3.8% and LW = 32.1 ± 4.4%; P<0.05, suggesting a temporary reduction in tumor-induced sodium retention. In contrast, urine output was significantly reduced in SW rats and increased in LW rats (LW up to -0.85 and SW up to 4.5 ml/100 g body weight, with no change in osmolar excretion. These temporary changes in the tumor's effects on LW rats may reflect a "reversal" of the secondary central antidiuretic response induced by the tumor (from antidiuretic to diuretic.

  7. Parenchymal neurocutaneous melanosis in association with intraventricular dermoid and Dandy-walker variant: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Joo; Won, Yoo Dong; Kim, Ki Tae; Chang, Eun Deok; Huh, Pil Woo [The Catholic University of Korea, College of Medicine, Uijongbu (Korea, Republic of)

    2006-06-15

    Neurocutaneous melanosis (NCM) is a rare congenital disease that is characterized by the presence of large or multiple congenital melanocytic nevi and melanotic lesions of the central nervous system. We report here on the CT and MR imaging findings of an unusual case of NCM that was associated with intraventricular dermoid and Dandy-Walker malformation.

  8. Neimark-Sacker bifurcations and evidence of chaos in a discrete dynamical model of walkers

    International Nuclear Information System (INIS)

    Rahman, Aminur; Blackmore, Denis

    2016-01-01

    Bouncing droplets on a vibrating fluid bath can exhibit wave-particle behavior, such as being propelled by interacting with its own wave field. These droplets seem to walk across the bath, and thus are dubbed walkers. Experiments have shown that walkers can exhibit exotic dynamical behavior indicative of chaos. While the integro-differential models developed for these systems agree well with the experiments, they are difficult to analyze mathematically. In recent years, simpler discrete dynamical models have been derived and studied numerically. The numerical simulations of these models show evidence of exotic dynamics such as period doubling bifurcations, Neimark–Sacker (N–S) bifurcations, and even chaos. For example, in [1], based on simulations Gilet conjectured the existence of a supercritical N-S bifurcation as the damping factor in his one- dimensional path model. We prove Gilet’s conjecture and more; in fact, both supercritical and subcritical (N-S) bifurcations are produced by separately varying the damping factor and wave-particle coupling for all eigenmode shapes. Then we compare our theoretical results with some previous and new numerical simulations, and find complete qualitative agreement. Furthermore, evidence of chaos is shown by numerically studying a global bifurcation.

  9. "It's Not so Much a Job but a Relationship": A Response to Romer and Walker

    Science.gov (United States)

    O'Brien, John

    2013-01-01

    Romer and Walker's "Appreciative Inquiry," which obtained input from 16 capable personal assistants, challenges some influential assumptions about personal assistance and opens a way to think about the demanding work of developing capable and committed personal assistants. Attempts to depersonalize the relationship between people…

  10. Computation of partially invariant solutions for the Einstein Walker manifolds' identifying equations

    Science.gov (United States)

    Nadjafikhah, Mehdi; Jafari, Mehdi

    2013-12-01

    In this paper, partially invariant solutions (PISs) method is applied in order to obtain new four-dimensional Einstein Walker manifolds. This method is based on subgroup classification for the symmetry group of partial differential equations (PDEs) and can be regarded as the generalization of the similarity reduction method. For this purpose, those cases of PISs which have the defect structure δ=1 and are resulted from two-dimensional subalgebras are considered in the present paper. Also it is shown that the obtained PISs are distinct from the invariant solutions that obtained by similarity reduction method.

  11. C. Walker-Said and J. D. Kelly (eds), Corporate Social Responsibility? Human Rights in the New Global Economy (Chicago, IL: The University of Chicago Press, 2015), 392 pp

    DEFF Research Database (Denmark)

    Whelan, Glen

    2017-01-01

    Book review of: Charlotte Walker-Said and John D. Kelly (eds), Corporate Social Responsibility? Human Rights in the New Global Economy (Chicago, IL: The University of Chicago Press, 2015), 392 pp.......Book review of: Charlotte Walker-Said and John D. Kelly (eds), Corporate Social Responsibility? Human Rights in the New Global Economy (Chicago, IL: The University of Chicago Press, 2015), 392 pp....

  12. Decorin is one of the proteoglycans expressed in Walker 256 rat mammary carcinoma

    Directory of Open Access Journals (Sweden)

    S.M. Oba-Shinjo

    2003-08-01

    Full Text Available Proteoglycan and glycosaminoglycan content was analyzed in a model of rat mammary carcinoma to study the roles of these compounds in tumorigenesis. Hyaluronic acid and proteoglycans bearing chondroitin and/or dermatan sulfate chains were detected in solid tumors obtained after subcutaneous inoculation of Walker 256 rat carcinoma cells. About 10% of sulfated glycosaminoglycan chains corresponded to heparan sulfate. The small leucine-rich proteoglycan, decorin, was identified as one of the proteoglycans, in addition to others of higher molecular weight, by cross-reaction with an antiserum raised against pig laryngeal decorin and by N-terminal amino acid sequencing. Decorin was separated from other proteoglycans by hydrophobic chromatography and its complete structure was determined. It has a molecular weight of about 85 kDa and a dermatan chain of 45 kDa with 4-sulfated disaccharides. After degradation of the glycosaminoglycan chain, three core proteins of different molecular weight (36, 46 and 56 kDa were identified. The presence of hyaluronic acid and decorin has been reported in a variety of tumors and tumor cells. In the Walker 256 mammary carcinoma model, hyaluronic acid may play an important role in tumor progression, since it provides a more hydrated extracellular matrix. On the other hand, decorin, which is expressed by stromal cells, represents a host defense response to tumor growth.

  13. Autoregressive-moving-average hidden Markov model for vision-based fall prediction-An application for walker robot.

    Science.gov (United States)

    Taghvaei, Sajjad; Jahanandish, Mohammad Hasan; Kosuge, Kazuhiro

    2017-01-01

    Population aging of the societies requires providing the elderly with safe and dependable assistive technologies in daily life activities. Improving the fall detection algorithms can play a major role in achieving this goal. This article proposes a real-time fall prediction algorithm based on the acquired visual data of a user with walking assistive system from a depth sensor. In the lack of a coupled dynamic model of the human and the assistive walker a hybrid "system identification-machine learning" approach is used. An autoregressive-moving-average (ARMA) model is fitted on the time-series walking data to forecast the upcoming states, and a hidden Markov model (HMM) based classifier is built on the top of the ARMA model to predict falling in the upcoming time frames. The performance of the algorithm is evaluated through experiments with four subjects including an experienced physiotherapist while using a walker robot in five different falling scenarios; namely, fall forward, fall down, fall back, fall left, and fall right. The algorithm successfully predicts the fall with a rate of 84.72%.

  14. POMT1-associated walker-warburg syndrome: a disorder of dendritic development of neocortical neurons.

    Science.gov (United States)

    Judas, M; Sedmak, G; Rados, M; Sarnavka, V; Fumić, K; Willer, T; Gross, C; Hehr, U; Strahl, S; Cuk, M; Barić, I

    2009-02-01

    We have analyzed the morphology and dendritic development of neocortical neurons in a 2.5-month-old infant with Walker-Warburg syndrome homozygotic for a novel POMT1 gene mutation, by Golgi methods. We found that pyramidal neurons frequently displayed abnormal (oblique, horizontal, or inverted) orientation. A novel finding of this study is that members of the same population of pyramidal neurons display different stages of development of their dendritic arborizations: some neurons had poorly developed dendrites and thus resembled pyramidal neurons of the late fetal cortex; for some neurons, the level of differentiation corresponded to that in the newborn cortex; finally, some neurons had quite elaborate dendritic trees as expected for the cortex of 2.5-month-old infant. In addition, apical dendrites of many pyramidal neurons were conspiciously bent to one side, irrespective to the general orientation of the pyramidal neuron. These findings suggest that Walker-Warburg lissencephaly is characterized by two hitherto unnoticed pathogenetic changes in the cerebral cortex: (a) heterochronic decoupling of dendritic maturation within the same neuronal population (with some members significantly lagging behind the normal maturational schedule) and (b) anisotropically distorted shaping of dendritic trees, probably caused by patchy displacement of molecular guidance cues for dendrites in the malformed cortex. Copyright Georg Thieme Verlag KG Stuttgart New York.

  15. DO INFANTS USING BABY WALKERS SUFFER DEVELOPMENTAL DELAYS IN ACQUISITION OF MOTOR SKILLS?

    OpenAIRE

    A. Talebian; A. Honarpishe; A. Taghavi; E. Fakharian; M. Parsa; GA. Mousavi

    2008-01-01

     AbstractObjectiveDevelopment is a complex process, completed over a specific period of time, through the maturation of the nervous system. It is affected by genetic, ethnic, nutritional, social, and economic factors; one of the environmental factors affecting the acquisition of motor skills in infants is the use of baby walkers. Since this device is very commonly used for infants in our country, we conducted this study to evaluate its effects on the acquisition of motor skills in this age gr...

  16. Effects of aquatic walking exercise using a walker in a chronic stroke patient

    OpenAIRE

    Matsuda, Tadashi; Akezaki, Yoshiteru

    2017-01-01

    [Purpose] The aim of this study was to examine the usefulness of aquatic walking exercise using a walker for chronic stroke patients. We also examined the psychological effects on the study subject and the primary caregiver before and after aquatic walking exercise. [Subject and Methods] The subject was a 60-year-old male with bilateral paralysis after a cerebrovascular accident. The Fugl-Meyer Assessment (FMA) total score was 116 on the right and 115 on the left. The intervention combined aq...

  17. Effects Of Walker 256 Carcinoma On Metabolic Alterations During The Evolution Of Pregnancy.

    OpenAIRE

    Cintra-Gomes M.C.; Cury L.; Parreira M.R.; Elias C.F.; Areas M.A.

    1990-01-01

    The control of pregnant cancer patients is difficult because it involves both mother and fetus, and the metabolic alterations in the cancer host induce a massive mobilization of nutrients diverted to the neoplastic cells. The purpose of the present study was to determine the evolution of the Walker 256 carcinoma in pregnant rats and its consequences on fetal development. The results showed that the tumors displayed a very rapid rate of growth and induced a reduction in fetal weights in the pr...

  18. WATER TEMPERATURE and other data from USS WALKER from 1991-07-01 to 1991-07-10 (NODC Accession 9100147)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data in this accession were collected from ship WALKER between July 1, 1991 to July 10, 1991. The real time data of water temperature at varying depth...

  19. Neuropsychological and Behavioural Phenotype of Dandy-Walker Variant Presenting in Chromosome 22 Trisomy: A Case Study

    Science.gov (United States)

    Searson, Ruth; Hare, Dougal Julian; Sridharan, Sridhar

    2013-01-01

    In this study, a case of Dandy-Walker variant syndrome associated with trisomy 22 in a 17-year-old man is described. This is the first account of this combination in a person surviving into adulthood, and the neuropsychological and behavioural presentation is described in detail and a clinical formulation is presented for the benefit of…

  20. Changes in Central Walker Lane Strain Accommodation near Bridgeport, California; as told by the Stanislaus Group

    Science.gov (United States)

    Carlson, C. W.; Pluhar, C. J.; Glen, J. M.; Farner, M. J.

    2012-12-01

    Accommodating ~20-25% of the dextral-motion between the Pacific and North American plates the Walker Lane is represented as an elongate, NW oriented, region of active tectonics positioned between the northwesterly-translating Sierra Nevada microplate and the east-west extension of the Basin and Range. This region of transtension is being variably accommodated on regional-scale systems of predominantly strike-slip faulting. At the western edge of the central Walker Lane (ca. 38°-39°N latitude) is a region of crustal-scale blocks bounded by wedge-shaped depositional-basins and normal-fault systems, here defined as the west-central Walker Lane (WCWL). Devoid of obvious strike-slip faulting, the presence of tectonic-block vertical-axis rotations in the WCWL represents unrecognized components of dextral-shearing and/or changes of strain-accommodation over time. We use paleomagnetic reference directions for Eureka Valley Tuff (EVT) members of the late Miocene Stanislaus Group as spatial and temporal markers for documentation of tectonic-block vertical-axis rotations near Bridgeport, CA. Study-site rotations revealed discrete rotational domains of mean vertical-axis rotation ranging from ~10°-30° with heterogeneous regional distribution. Additionally, the highest measured magnitudes of vertical-axis rotation (~50°-60° CW) define a 'Region of High Strain' that includes the wedge-shaped Bridgeport Valley (Basin). This study revealed previously-unrecognized tectonic rotation of reference direction sites from prior studies for two (By-Day and Upper) of the three members of the EVT, resulting in under-estimates of regional strain accommodation by these studies. Mean remanent directions and virtual geomagnetic poles utilized in our study yielded a recalculated reference direction for the By-Day member of: Dec.=353.2°; Inc.= 43.7°; α95=10.1, in agreement with new measurements in the stable Sierra Nevada. This recalculated direction confirmed the presence of previously

  1. Stability of geodesic imcompleteness for Robertson-Walker space-times

    International Nuclear Information System (INIS)

    Beem, J.K.

    1981-01-01

    Let (M,g) be a Lorentzian warped product space-time M = (a, b) X H,g = -dt 2 x fh, where -infinity -infinity and (H,h) is homogeneous, then the past incompleteness of every timelike geodesic of (M,g) is stable under small C 0 perturbations in the space Lor(M) of Lorentzian metrics for M. Also it is shown that if (H,h) is isotropic and (M,g) contains a past-inextendible, past-incomplete null geodesic, then the past incompleteness of all null geodesics is stable under small C 1 perturbations in Lor(M). Given either the isotropy or homogeneity of the Riemannian factor, the background space-time (M,g) is globally hyperbolic. The results of this paper, in particular, answer a question raised by D. Lerner for big bang Robertson-Walker cosmological models affirmatively. (author)

  2. Review of the North American species of Marimatha Walker with descriptions of three new species (Lepidoptera, Noctuidae, Eustrotiinae and the description of Pseudomarimatha flava (Noctuinae, Elaphriini, a new genus and species confused with Marimatha

    Directory of Open Access Journals (Sweden)

    Clifford Ferris

    2010-03-01

    Full Text Available Seven species of Marimatha Walker are examined, five of which occur in North America. In addition to the existing species M. nigrofimbria (Guenee, M. tripuncta (Moschler is reported from North America for the first time and three new species are described from southwestern North America: M. piscimala, M. squala, and M. quadrata. Marimatha alboflava (Walker, M. botyoides (Guenee, and M. dinumeratalis (Walker are discussed in terms of the generic name Marimatha, and M. aurifera (Walker is discussed in relation to the identity of M. tripuncta. A generic diagnosis, key to species, descriptions, and illustrations of adults and genitalia are included. A new genus and species is proposed for a species currently placed as an undescribed species of Marimatha, but tympanal and genital characters and mtDNA suggest an association with the subfamily Noctuinae, tribe Elaphriini.

  3. Comparing Arc-shaped Feet and Rigid Ankles with Flat Feet and Compliant Ankles for a Dynamic Walker

    DEFF Research Database (Denmark)

    Kuhlemann, Ilyas; Matthias Braun, Jan; Wörgötter, Florentin

    2014-01-01

    In this paper we show that exchanging curved feet and rigid ankles by at feet and compliant ankles improves the range of gait parameters for a bipedal dynamic walker. The new lower legs were designed such that they t to the old set-up, allowing for a direct and quantitative comparison. The dynamic...

  4. Dandy Walker Syndrome with Unusual Associated Findings in a Fetal Autopsy Study

    Directory of Open Access Journals (Sweden)

    Surekha U Arakeri

    2015-01-01

    Full Text Available Dandy Walker Syndrome (DWS is a congenital brain malformation characterized by hypoplasia or absence of cerebellar vermis, cystic dilatation of fourth ventricle and hydrocephalus. It is frequently associated with other congenital anomalies. Associated central nervous system anomalies such as agenesis of corpus callosum and vermis are associated with poor prognosis. Association of DWS with congenital absence of spleen is life threatening condition and has been reported very rarely. Autopsy findings of DWS with association of congenital absence of corpus callosum, vermis and spleen are reported in a stillborn fetus of 28 weeks gestation and review of relevant literature was done

  5. Modeling the Excess Cell Surface Stored in a Complex Morphology of Bleb-Like Protrusions.

    Directory of Open Access Journals (Sweden)

    Maryna Kapustina

    2016-03-01

    Full Text Available Cells transition from spread to rounded morphologies in diverse physiological contexts including mitosis and mesenchymal-to-amoeboid transitions. When these drastic shape changes occur rapidly, cell volume and surface area are approximately conserved. Consequently, the rounded cells are suddenly presented with a several-fold excess of cell surface whose area far exceeds that of a smooth sphere enclosing the cell volume. This excess is stored in a population of bleb-like protrusions (BLiPs, whose size distribution is shown by electron micrographs to be skewed. We introduce three complementary models of rounded cell morphologies with a prescribed excess surface area. A 2D Hamiltonian model provides a mechanistic description of how discrete attachment points between the cell surface and cortex together with surface bending energy can generate a morphology that satisfies a prescribed excess area and BLiP number density. A 3D random seed-and-growth model simulates efficient packing of BLiPs over a primary rounded shape, demonstrating a pathway for skewed BLiP size distributions that recapitulate 3D morphologies. Finally, a phase field model (2D and 3D posits energy-based constitutive laws for the cell membrane, nematic F-actin cortex, interior cytosol, and external aqueous medium. The cell surface is equipped with a spontaneous curvature function, a proxy for the cell surface-cortex couple, that is a priori unknown, which the model "learns" from the thin section transmission electron micrograph image (2D or the "seed and growth" model image (3D. Converged phase field simulations predict self-consistent amplitudes and spatial localization of pressure and stress throughout the cell for any posited stationary morphology target and cell compartment constitutive properties. The models form a general framework for future studies of cell morphological dynamics in a variety of biological contexts.

  6. Anandan quantum phase for a neutral particle with Fermi-Walker reference frame in the cosmic string background

    International Nuclear Information System (INIS)

    Bakke, Knut; Furtado, C.

    2010-01-01

    We study geometric quantum phases in the relativistic and non-relativistic quantum dynamics of a neutral particle with a permanent magnetic dipole moment interacting with two distinct field configurations in a cosmic string spacetime. We consider the local reference frames of the observers are transported via Fermi-Walker transport and study the influence of the non-inertial effects on the phase shift of the wave function of the neutral particle due to the choice of this local frame. We show that the wave function of the neutral particle acquires non-dispersive relativistic and non-relativistic quantum geometric phases due to the topology of the spacetime, the interaction between the magnetic dipole moment with external fields and the spin-rotation coupling. However, due to the Fermi-Walker reference frame, no phase shift associated to the Sagnac effect appears in the quantum dynamics of a neutral particle. We show that in the absence of topological defect, the contribution to the quantum phase due to the spin-rotation coupling is equivalent to the Mashhoon effect in non-relativistic dynamics. (orig.)

  7. Finite-temperature effects in the φ4-model in a Robertson-Walker universe

    International Nuclear Information System (INIS)

    Kundu, P.K.

    1987-01-01

    The computation of the one-loop trace anomaly in a massless, conformally coupled φ 4 -model displaying spontaneous symmetry breaking in a spatially flat Robertson-Walker universe investigated in a previous paper, is extended to the case in which the physical system is in a state of thermal equilibrium. It is found that due to a nonperturbative nature of this effect the anomalous trace exhibits a rather nontrivial temperature dependence and cannot be expressed as a sum of contributions from the vacuum state and an ideal black-body radiation gas

  8. Biological aspects of Periga circumstans Walker, 1855 (Lepidoptera: Saturniidae: Hemileucinae with larvae reared on khaki and mate-plant leaves

    Directory of Open Access Journals (Sweden)

    A. Specht

    Full Text Available The goal of the present study was to investigate biological aspects of Periga circumstans Walker, 1855 (Lepidoptera: Saturniidae: Hemileucinae whose larvae were fed on leaves of khaki-plant (Diospyros khaki Linnaeus - Ebenaceae and Mate-plant (Ilex paraguariensis Saint Hilaire - Aquifoliaceae leaves. The biological parameters were obtained from specimens kept under controlled conditions: temperature of 25 ± 1 °C, relative humidity of 70 ± 10%, and photoperiod of 12 hours. For each developmental stage, morphological and ethological parameters are described. The larvae passed through six instars with a growth average rate of 1.4 for each instar. The host plants influenced significantly only the total duration of the larval phase, which was prolonged for larvae fed on khaki-plant leaves. Several aspects related to the morphology and the ethology of P. circumstans are similar to those described for Lonomia obliqua Walker, 1855.

  9. Effects of field interactions upon particle creation in Robertson-Walker universes

    International Nuclear Information System (INIS)

    Birrell, N.D.; Davies, P.C.W.; Ford, L.H.

    1980-01-01

    Particle creation due to field interactions in an expanding Robertson-Walker universe is investigated. A model in which pseudoscalar mesons and photons are created as a result of their mutual interaction is considered, and the energy density of created particles is calculated in model universes which undergo a bounce at some maximum curvature. The free-field creation of non-conformally coupled scalar particles and of gravitons is calculated in the same space-times. It is found that if the bounce occurs at a sufficiently early time the interacting particle creation will dominate. This result may be traced to the fact that the model interaction chosen introduces a length scale which is much larger than the Planck length. (author)

  10. Dandy-walker malformation and the contribution of radioisotopic studies of cerebral spinal fluid dynamics to its diagnosis

    International Nuclear Information System (INIS)

    Palma, A.; Nazar, N.; Castro, M.; Olea, E.; Guzmann, G.

    1982-01-01

    On case of Dandy-Walker malformation is described. The diagnosis was mainly reached by dynamic isotope studies of CSF, and was confirmed by axial computerized tomography. The importance of these examinations is discussed, not only as a means of understanding the aetiopathology, but especially because of the functional information they give and the therapeutic consequences they have. (Author)

  11. Rapid Communication. Tamarixia monesus (Walker (Hym.: Eulophidae parasitoid of Bactericera tremblayi (Wagner, 1961 (Hemiptera: Triozidae in Iran

    Directory of Open Access Journals (Sweden)

    Lotfalizadeh Hossein

    2016-08-01

    Full Text Available Bactericera tremblayi (Wagner, 1961 (Hemiptera: Triozidae is reported on Brassica oleracea var. capitata (Brassicaceae in northwestern Iran. Tamarixia monesus (Walker (Hymenoptera: Chalcidoidea, Eulophidae was reared for the first time on B. tremblayi, and compared with Tamarixia tremblayi, another parasitoid of B. tremblayi. This is a new record of T. monesus from the Middle East.

  12. Case 3724 - Metochus abbreviatus Scott, 1874 (Insecta, Heteroptera): proposed precedence over Rhyparochromus erosus Walker, 1872 (currently Metochus erosus)

    Science.gov (United States)

    The purpose of this application, under Article 23.9.3 of the Code, is to conserve the widely used specific name Metochus abbreviatus Scott, 1874, for a species of rhyparochromid bugs from East Asia. The name is threatened by the senior subjective synonym Metochus erosus (Walker, 1872), which has bee...

  13. 75 FR 19880 - Safety Zone; BW PIONEER at Walker Ridge 249, Outer Continental Shelf FPSO, Gulf of Mexico

    Science.gov (United States)

    2010-04-16

    ... BW PIONEER, a Floating Production, Storage and Offloading (FPSO) system, at Walker Ridge 249 in the Outer Continental Shelf. The purpose of the safety zone is to protect the FPSO from vessels operating... reduces the threat of allisions, oil spills, and releases of natural gas, and thereby protects the safety...

  14. Needle Revision With 5-fluorouracil for the Treatment of Ahmed Glaucoma Valve Filtering Blebs: 5-Fluoruracil Needling Revision can be a Useful and Safe Tool in the Management of Failing Ahmed Glaucoma Valve Filtering Blebs.

    Science.gov (United States)

    Quaranta, Luciano; Floriani, Irene; Hollander, Lital; Poli, Davide; Katsanos, Andreas; Konstas, Anastasios G P

    2016-04-01

    To determine the outcome of needling with adjunctive 5-fluorouracil (5-FU) in patients with a failing Ahmed glaucoma valve (AGV) implant, and to identify predictors of long-term intraocular pressure (IOP) control. A prospective observational study was performed on consecutive patients with medically uncontrolled primary open-angle glaucoma (POAG) with AGV encapsulation or fibrosis and inadequate IOP control. Bleb needling with 5-FU injection (0.1 mL of 50 mg/mL) was performed at the slit-lamp. Patients were examined 1 week following the needling, and then at months 1, 3, and 6. Subsequent follow-up visits were scheduled at 6-month intervals for at least 2 years. Needling with 5-FU was repeated no more than twice during the first 3 months of the follow-up. Procedure outcome was determined on the basis of the recorded IOP levels. Thirty-six patients with an encapsulated or fibrotic AGV underwent 67procedures (mean 1.86 ± 0.83). Complete success, defined as IOP ≤ 18 mm Hg without medications, was obtained in 25% at 24 months of observation. The cumulative proportion of cases achieving either qualified (ie, IOP ≤ 18 mm Hg with medications) or complete success at 24 months of observation was 72.2%. In a univariate Cox proportional hazards model, age was the only variable that independently influenced the risk of failing 5-FU needling revision. Fourteen eyes (38.8%) had a documented complication. Needling over the plate of an AGV supplemented with 5-FU is an effective and safe choice in a significant proportion of POAG patients with elevated IOP due to encapsulation or fibrosis.

  15. Vaidya--Patel solution with Robertson--Walker metric as a rotating inflationary scenario

    International Nuclear Information System (INIS)

    Groen, O.; Soleng, H.H.

    1988-01-01

    The Vaidya--Patel solution of a rotating homogeneous fluid in the presence of a Maxwellian source-free electromagnetic field is interpretated as an inflationary scenario with a gauge field with local U(1) symmetry, a vacuum energy, and a rotating perfect fluid. An explicit solution is found to be expressible in terms of known solutions representing the radiation filled Robertson--Walker universe with a cosmological term. In the case that the rotating fluid is radiation, the discussion of the model is considerably simplified. How the time scale of transition into a pseudo-de Sitter stage, as observed by an observer following the rotating fluid, is affected by vorticity is also studied

  16. Changes in Energy Cost and Total External Work of Muscles in Elite Race Walkers Walking at Different Speeds

    Directory of Open Access Journals (Sweden)

    Chwała Wiesław

    2014-12-01

    Full Text Available The aim of the study was to assess energy cost and total external work (total energy depending on the speed of race walking. Another objective was to determine the contribution of external work to total energy cost of walking at technical, threshold and racing speed in elite competitive race walkers.

  17. Comparative study of magnetic properties and the anticancer effect of superparamagnetic and ferromagnetic iron oxide nanoparticles in the nanocomplex with doxorubicin

    International Nuclear Information System (INIS)

    Orel, V.E.; Shevchenko, A.D.; Rikhal's'kij, O.Yu.; Romanov, A.V.; Orel, Yi.V.; Lukyin, S.M.; Burlaka, A.P.; Venger, Je.F.

    2015-01-01

    Mechano-magneto-chemically synthesized magnetic nanocomplex (MNC) of superparamagnetic iron oxide Fe 3 O 4 nanoparticles (NP) and anticancer drug doxorubicin (DR) had significantly lower saturation magnetic moment and magnetic hysteresis loop area as compared to the MNC of ferro- magnetic NP. However, the last was characterized by lower coercivity. MNC of superparamagnetic NP and DR had g-factors of 2.00, 2.30, and 4.00. MNC of ferromagnetic NP and DR had the g-factor of 2.50, and the integrated intensity of electron spin resonance signals was by 61% greater. Superparamagnetic iron oxide Fe 3 O 4 NP in MNC with DR initiated a greater antitumor effect during magnetic nanotherapy of animals with carcinosarcoma Walker-256 as compared to the MNC composed of ferromagnetic NP and DR. In the future, superparamagnetic iron oxide Fe 3 O 4 NP as a part of the nanocomplex with DR can be used in theranostics - a methodology that combines magnetic resonance diagnostics and magnetic nanotherapy using MNC both as therapeutic and diagnostic agents

  18. Alterations caused by physical training in pulmonary edema and loss of muscle mass in rats with Walker-256 tumor Alterações promovidas pelo treinamento físico no edema pulmonar e perda de massa muscular em ratos portadores de tumor Walker-256

    Directory of Open Access Journals (Sweden)

    Rubens Cecchini

    2008-10-01

    Full Text Available Walker-256 tumor is a fast-growing tumor and has been studied under several metabolic aspects associated or not to cachexia. It was observed in our laboratory that animals with Walker-256 tumor, after spontaneous death (usually around the fifteenth day, showed significant pulmonary edema with fluid in the pleural cavity. Some studies have suggested that physical training improves the survival of animals with tumor and minimizes the effects of cachexia. The purpose of our work was to assess the pulmonary edema index as well as the cardiac and skeletal muscle mass, besides the survival of rats with Walker-256 tumor submitted previously to physical training through swimming (N. For this study male Wistar rats (200 to 220 g were used, submitted to physical training through swimming (1 hour; 5 days a week, four weeks. One day after the training, sedentary rats (C or trained ones (N were submitted to inoculation on the right flank of 8 x 107 Walker-256 tumor cells (T. Immediately after spontaneous death of these animals, the pulmonary edema index (PEI, cardiac and skeletal muscle mass (gastrocnemius and soleus were evaluated. Pulmonary edema was evaluated through the index calculated by the relation between lung and body weights of each animal, and multiplied by 100 (PP/PC x 100 (LEE et al., 2001. Muscle mass (MM index was calculated similarly. In normal animals the PEI is equal to 0,53±0,02 (n=20. In tumor-bearing rats after spontaneous death the PEI was significantly higher (2,62±0,31, n=18. After the physical training in rats without tumor, the PEI was 0,55±0,03 (n=5. Whereas in tumor-bearing rats previously trained, it was obtained a pulmonary edema index lower than that of the control group with tumor (1,46±0,16, n=5; pO tumor Walker-256 é um carcinoma de crescimento rápido e tem sido estudado sob vários aspectos metabólicos, associados ou não, à caquexia. Foi observado, em nosso laboratório, que em animais portadores de tumor Walker

  19. Organic geochemistry and brine composition in Great Salt, Mono, and Walker Lakes

    Science.gov (United States)

    Domagalski, Joseph L.; Orem, W.H.; Eugster, H.P.

    1989-01-01

    Samples of Recent sediments, representing up to 1000 years of accumulation, were collected from three closed basin lakes (Mono Lake, CA, Walker Lake, NV, and Great Salt Lake, UT) to assess the effects of brine composition on the accumulation of total organic carbon, the concentration of dissolved organic carbon, humic acid structure and diagenesis, and trace metal complexation. The Great Salt Lake water column is a stratified Na-Mg-Cl-SO4 brine with low alkalinity. Algal debris is entrained in the high density (1.132-1.190 g/cc) bottom brines, and in this region maximum organic matter decomposition occurs by anaerobic processes, with sulfate ion as the terminal electron acceptor. Organic matter, below 5 cm of the sediment-water interface, degrades at a very slow rate in spite of very high pore-fluid sulfate levels. The organic carbon concentration stabilizes at 1.1 wt%. Mono Lake is an alkaline (Na-CO3-Cl-SO4) system. The water column is stratified, but the bottom brines are of lower density relative to the Great Salt Lake, and sedimentation of algal debris is rapid. Depletion of pore-fluid sulfate, near l m of core, results in a much higher accumulation of organic carbon, approximately 6 wt%. Walker Lake is also an alkaline system. The water column is not stratified, and decomposition of organic matter occurs by aerobic processes at the sediment-water interface and by anaerobic processes below. Total organic carbon and dissolved organic carbon concentrations in Walker Lake sediments vary with location and depth due to changes in input and pore-fluid sulfate concentrations. Nuclear magnetic resonance studies (13C) of humic substances and dissolved organic carbon provide information on the source of the Recent sedimentary organic carbon (aquatic vs. terrestrial), its relative state of decomposition, and its chemical structure. The spectra suggest an algal origin with little terrestrial signature at all three lakes. This is indicated by the ratio of aliphatic to

  20. Energy-momentum tensor and definition of particle states for Robertson-Walker space-time

    International Nuclear Information System (INIS)

    Brown, M.R.; Dutton, C.R.

    1978-01-01

    A new regularization scheme is developed for calculating expectation values of the energy-momentum tensor of a quantized scalar field in Robertson-Walker space-times. Using this regularized stress tensor we consider a definition for the vacuum state of the scalar field on any initial hypersurface. Asymptotic methods are developed to investigate the structure of both the divergent and finite terms of the stress tensor when evaluated in this state. The conformal anomaly is discussed in the context of this model. It does not naturally enter into the analysis and we argue that its inclusion is unnecessary

  1. Field diet of the grasshopper Abracris dilecta Walker (Orthoptera, Acrididae

    Directory of Open Access Journals (Sweden)

    Carlos Frankl Sperber

    1996-01-01

    Full Text Available Abracris dilecta Walker, 1870 (Orthoptera, Acrididae, Ommatolampinae ate leafs of at least 14 plant species, in the families Asteraceae, Lamiaceae, Malvales (Sterculiaceae, Tiliaceae or Malvaceae, Poaceae, Fabaceae, Verbenaceae, Aristolochiaceae, Rubiaceae and Melastomataccae. Elephantopus mollis H.B.K. (Asteraceae and Hyptis suaveolens Poit. (Lamiaceae comprised 50% of the diet. The diet breadth of A. dilecta was compared to that of other 11 grasshopper species of the same sub-family, with rarefaction curves. The number of plant species eaten by A. dilecta was greater than that of nine other grasshopper species of the same sub-family (Rhachicreagra spp. but was lower then two others (Microptylopteryx hebardi Rehn, 1905 and Rhachicreagra astytophallus Jago & Rowell, 1981. This results are discussed in view of the broad geographical range and possession of developed wings by A. dilecta, which contrasts with most Ommatolampinae grasshoppers.

  2. Lonomia obliqua Walker (Lepidoptera: Saturniidae: hemostasis implications

    Directory of Open Access Journals (Sweden)

    Silviane Maggi

    2015-06-01

    Full Text Available Summary In southern Brazil, since 1989, several cases of accidents produced by unwilling contact with the body of poisonous caterpillars of the moth species Lonomia obliqua Walker, 1855 (Lepidoptera: Saturniidae, were described. L. obliqua caterpillars have gregarious behavior and feed on leaves of host trees during the night, staying grouped in the trunk during the day, which favors the occurrence of accidents with the species. This caterpillar has the body covered with bristles that on contact with the skin of individuals, breaks and release their contents, inoculating the venom into the victim. The basic constitution of the venom is protein and its components produce physiological changes in the victim, which include disturbances in hemostasis. Hemorrhagic syndrome associated with consumption coagulopathy, intravascular hemolysis and acute renal failure are some of the possible clinical manifestations related to poisoning by L. obliqua. Specific laboratory tests for diagnosis of poisoning have not been described previously. The diagnosis of poisoning is made based on the patient's medical history, clinical manifestations, erythrocyte levels, and, primarily, parameters that evaluate blood coagulation. Treatment is performed with the use of supportive care and the administration of specific hyperimmune antivenom. Poisoning can be serious and even fatal.

  3. Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2

    DEFF Research Database (Denmark)

    Henriksen, Ulla Birk; Gether, Ulrik; Litman, Thomas

    2005-01-01

    The ATP binding cassette (ABC) half-transporter ABCG2 (MXR/BCRP/ABCP) is associated with mitoxantrone resistance accompanied by cross-resistance to a broad spectrum of cytotoxic drugs. Here we investigate the functional consequences of mutating a highly conserved lysine in the Walker A motif...

  4. Neurodevelopment in preschool idiopathic toe-walkers.

    Science.gov (United States)

    Martín-Casas, P; Ballestero-Pérez, R; Meneses-Monroy, A; Beneit-Montesinos, J V; Atín-Arratibel, M A; Portellano-Pérez, J A

    2017-09-01

    Idiopathic toe walking, a differential diagnosis for neurological and orthopaedic disorders, has been associated with neurodevelopmental alterations. Neurodevelopmental assessment at early ages using specific tests may improve management and follow-up of these patients. The aim of our study is to analyse the neurodevelopmental characteristics of preschool idiopathic toe-walkers (ITW) by comparing them to a control group. Our descriptive cross-sectional study compared possible risk factors, neurodevelopmental characteristics, and scores on the Child Neuropsychological Maturity Questionnaire (CUMANIN) between a group of 56 ITWs aged 3 to 6 and a control group including 40 children. The proportion of males was significantly higher in the ITW group (P=.008). The percentage of patients with a family history (P=.000) and biological risk factors during the perinatal period (P=.032) was also higher in this group. According to the parents' reports, motor coordination in ITWs was significantly poorer (59%; P=.009). ITWs scored significantly lower on CUMANIN subscales of psychomotricity (=0,001) and memory (P=.001), as well as in verbal development (P=.000), non-verbal development (P=.026), and overall development (P=.004). Foot preference was less marked in the ITW group (P=.047). The neurodevelopmental characteristics of our sample suggest that idiopathic toe walking is a marker of neurodevelopmental impairment. However, further studies are necessary to confirm these findings. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Comments on the Dirac field in Friedmann-Robertson-Walker spacetime

    International Nuclear Information System (INIS)

    Khanal, U.

    2006-12-01

    Some further consequences about the massive Dirac field in Friedmann-Robertson-Walker universe are drawn. The comoving momenta of the particles in a closed universe are found to be quantized in units of half-integer, half being the contribution of the spin. This suggests that a gravitationally trapped fermion will have its momentum quantized. Both the comoving particle number and energy density are found not to be conserved in any finite volume of the universe. There exists a finite current that tends to enhance the density contrast. A series solution for the temporal part is used to show this effect. The particles distribute themselves in such a way as to resemble that required for the flattened rotation curves of galaxies. Although the total energy current grows with r, it is found that the current density, through unit area, goes down after attaining a peak. (author)

  6. Laminin beta 2 chain and adhalin deficiency in the skeletal muscle of Walker-Warburg syndrome (cerebro-ocular dysplasia-muscular dystrophy)

    DEFF Research Database (Denmark)

    Wewer, U M; Durkin, M E; Zhang, X

    1995-01-01

    Muscular dystrophy may be caused by disturbances in a number of muscle proteins that appear to be part of a chain of interacting molecules that includes cytoskeletal, cell membrane, and basement membrane components. We found that the skeletal muscle cells in two cases of Walker-Warburg syndrome w...

  7. Overground walking training with the i-Walker, a robotic servo-assistive device, enhances balance in patients with subacute stroke: a randomized controlled trial.

    Science.gov (United States)

    Morone, Giovanni; Annicchiarico, Roberta; Iosa, Marco; Federici, Alessia; Paolucci, Stefano; Cortés, Ulises; Caltagirone, Carlo

    2016-05-26

    Patients affected by mild stroke benefit more from physiological overground walking training than walking-like training performed in place using specific devices. The aim of the study was to evaluate the effects of overground robotic walking training performed with the servo-assistive robotic rollator (i-Walker) on walking, balance, gait stability and falls in a community setting in patients with mild subacute stroke. Forty-four patients were randomly assigned to two different groups that received the same therapy in two daily 40-min sessions 5 days a week for 4 weeks. Twenty sessions of standard therapy were performed by both groups. In the other 20 sessions the subjects enrolled in the i-Walker-Group (iWG) performed with the i-Walker and the Control-Group patients (CG) performed the same amount of conventional walking oriented therapy. Clinical and instrumented gait assessments were made pre- and post-treatment. The follow-up observation consisted of recording the number of fallers in the community setting after 6 months. Treatment effectiveness was higher in the iWG group in terms of balance improvement (Tinetti: 68.4 ± 27.6 % vs. 48.1 ± 33.9 %, p = 0.033) and 10-m and 6-min timed walking tests (significant interaction between group and time: F(1,40) = 14.252, p = 0.001; and F(1,40) = 7.883, p = 0.008, respectively). When measured, latero-lateral upper body accelerations were reduced in iWG (F = 4.727, p = 0.036), suggesting increased gait stability, which was supported by a reduced number of falls at home. A robotic servo-assisted i-Walker improved walking performance and balance in patients affected by mild/moderate stroke, leading to increased gait stability and reduced falls in the community. This study was registered on anzctr.org.au (July 1, 2015; ACTRN12615000681550 ).

  8. Secondary Malignancy As A Manifestation Of Late Toxicity Of Curative Treatment For Testicular Cancer

    International Nuclear Information System (INIS)

    Reckova, M.; Kakalejcik, M.; Beniak, J.; Boljesikova, E.

    2008-01-01

    The case presents the patient with a diagnosis of bladder carcinosarcoma. He was diagnosed 42 years after adjuvant middle abdominal and pelvic radiotherapy for testicular seminoma. We discuss the problem of late toxicity of oncology treatment in patients with potentially curative germ cell tumors of testes together with diagnosis and treatment of patients with bladder carcinoma and carcinosarcoma. (author)

  9. Comparison of range of motion and function of subjects with reverse anatomy Bayley-Walker shoulder replacement with those of normal subjects.

    Science.gov (United States)

    Masjedi, Milad; Lovell, Cara; Johnson, Garth R

    2011-12-01

    Patients with rotator cuff tear and degenerative shoulder joint disease commonly experience severe pain and reduced performance during activities of daily living. A popular way to treat these patients is by means of reverse anatomy shoulder prosthesis. Studying the kinematics of subjects with reverse anatomy implant would be useful in order to gain knowledge about functionality of different designs. It is hypothesized that the kinematics of these subjects, in the absence of rotator cuff muscles, differs from that of normal subjects. In this study the upper limb kinematics of 12 subjects with a Bayley-Walker reverse anatomy shoulder prosthesis while performing tasks common in everyday activities and those that represent the range of motion was analyzed and compared to that of 12 normal subjects. Each patient also completed an Oxford Shoulder Score. Substantial reduction in the Bayley-Walker subjects' ranges of motion was observed compared to normal subjects. The mean abduction angle decreased from 109° (±20) for normal subjects to 64° (±25). A similar trend was observed during flexion and axial rotation tasks. Furthermore, the normal group showed less variable ranges of motion performing the standard tasks, whereas for the prosthetic group this varied greatly, which is likely to be dependent on muscle strength. Although the decreased range of motion was prominent, subjects were able to complete most of the tasks by compensating with their elbow and trunk. The most challenging task for Bayley-Walker subjects was lifting an object to head height. Copyright © 2010 Elsevier B.V. All rights reserved.

  10. Description of a new species and subspecies of Idalus Walker from Costa Rica, Honduras and Guatemala (Lepidoptera, Erebidae, Arctiinae, Arctiini)

    Science.gov (United States)

    Espinoza, Bernardo A.; Janzen, Daniel H.; Winnie Hallwachs;  J. Bolling Sullivan

    2013-01-01

    Abstract A new species and subspecies of Idalus Walker are described from Costa Rica, Honduras and Guatemala. Images of males and females and their genitalia are provided. Locality information and distribution maps for Costa Rica and for Guatemala are included. The biology and phylogeny of Idalus are discussed. PMID:23730178

  11. A phase II evaluation of ixabepilone in the treatment of recurrent/persistent carcinosarcoma of the uterus, an NRG Oncology/Gynecologic Oncology Group study.

    Science.gov (United States)

    McCourt, Carolyn K; Deng, Wei; Dizon, Don S; Lankes, Heather A; Birrer, Michael J; Lomme, Michele M; Powell, Matthew A; Kendrick, James E; Saltzman, Joel N; Warshal, David; Tenney, Meaghan E; Kushner, David M; Aghajanian, Carol

    2017-01-01

    The primary objectives were to determine the objective response rate (ORR) and safety profile of ixabepilone in women with recurrent or persistent uterine carcinosarcoma (UCS). Secondary objectives included progression-free survival (PFS) and overall survival (OS). Exploratory translational objectives included characterization of class III beta tubulin expression and its association with response, PFS, and OS. Patients had measurable disease; up to two prior chemotherapeutic regimens were allowed, but must have included a taxane. Women received ixabepilone 40mg/m 2 as a 3hour IV infusion on day 1 of a 21daycycle. Treatment was continued until disease progression or unacceptable toxicity occurred. Forty-two women were enrolled, with 34 eligible and evaluable. Median age was 68years. ECOG performance status was 0 in 56% of women, 38% had received radiation, and 15% had received 2 lines of chemotherapy. Overall ORR was 11.8% (4/34, 90% CI 4.2-25.1%); all were partial responses. Stable disease for at least 8weeks was achieved in 8 patients (23.5%). Median PFS and OS were 1.7mo and 7.7mo, respectively, with a median follow-up of 37mo. Six month PFS was 20.6%. Major grade≥3 toxicities were neutropenia (47%), fatigue (15%), dehydration (15%), hypertension (15%), and hyponatremia (15%); grade 2 peripheral neuropathy was reported in 18%. In this small sample size, class III beta tubulin expression in the primary tumor was not associated with the response to ixabepilone, PFS, or OS. In this cohort of women, single agent ixabepilone showed modest but insufficient clinical activity. Copyright © 2016. Published by Elsevier Inc.

  12. Effect of electromagnetic fields on the creation of scalar particles in a flat Robertson-Walker space-time

    International Nuclear Information System (INIS)

    Haouat, S.; Chekireb, R.

    2012-01-01

    The influence of electromagnetic fields on the creation of scalar particles from vacuum in a flat Robertson-Walker space-time is studied. The Klein-Gordon equation with varying electric field and constant magnetic one is solved. The Bogoliubov transformation method is applied to calculate the pair creation probability and the number density of created particles. It is shown that the electric field amplifies the creation of scalar particles while the magnetic field minimizes it. (orig.)

  13. Leucine-rich diet alters the 1H-NMR based metabolomic profile without changing the Walker-256 tumour mass in rats.

    Science.gov (United States)

    Viana, Laís Rosa; Canevarolo, Rafael; Luiz, Anna Caroline Perina; Soares, Raquel Frias; Lubaczeuski, Camila; Zeri, Ana Carolina de Mattos; Gomes-Marcondes, Maria Cristina Cintra

    2016-10-03

    Cachexia is one of the most important causes of cancer-related death. Supplementation with branched-chain amino acids, particularly leucine, has been used to minimise loss of muscle tissue, although few studies have examined the effect of this type of nutritional supplementation on the metabolism of the tumour-bearing host. Therefore, the present study evaluated whether a leucine-rich diet affects metabolomic derangements in serum and tumour tissues in tumour-bearing Walker-256 rats (providing an experimental model of cachexia). After 21 days feeding Wistar female rats a leucine-rich diet, distributed in L-leucine and LW-leucine Walker-256 tumour-bearing groups, we examined the metabolomic profile of serum and tumour tissue samples and compared them with samples from tumour-bearing rats fed a normal protein diet (C - control; W - tumour-bearing groups). We utilised 1 H-NMR as a means to study the serum and tumour metabolomic profile, tumour proliferation and tumour protein synthesis pathway. Among the 58 serum metabolites examined, we found that 12 were altered in the tumour-bearing group, reflecting an increase in activity of some metabolic pathways related to energy production, which diverted many nutrients toward tumour growth. Despite displaying increased tumour cell activity (i.e., higher Ki-67 and mTOR expression), there were no differences in tumour mass associated with changes in 23 metabolites (resulting from valine, leucine and isoleucine synthesis and degradation, and from the synthesis and degradation of ketone bodies) in the leucine-tumour group. This result suggests that the majority of nutrients were used for host maintenance. A leucine rich-diet, largely used to prevent skeletal muscle loss, did not affect Walker 256 tumour growth and led to metabolomic alterations that may partially explain the positive effects of leucine for the whole tumour-bearing host.

  14. Problems of older persons using a wheeled walker.

    Science.gov (United States)

    Lindemann, Ulrich; Schwenk, Michael; Klenk, Jochen; Kessler, Max; Weyrich, Michael; Kurz, Franziska; Becker, Clemens

    2016-04-01

    Wheeled walkers (WWs) are used to improve mobility and for fall prevention in older persons, but not all users are satisfied with the usability of WWs. Intelligent WWs are being developed to improve the usability. The aim of this study was to support the development of intelligent WWs by investigating possible problems of using a WW. This study investigated 22 geriatric in-patients (median age 82 years) with and without their WW while opening a door against the direction of walking and passing through. Other possible problems when using WWs were identified by interview. Walking through the door was faster without than with using the WW (8.71 versus 12.86 s, p < 0.001), while interference between door and WW was documented in 41 of 44 (93 %) cases. Backward walking performance was better when using a WW with regard to gait speed, step width and walk ratio (all p < 0.002). Most referred problems when using a WW were walking downhill (83 %) and uphill (77 %) and obstacle crossing in general (77 %). Problems with opening a door against the direction of walking and the optimization of downhill and uphill walking as well as obstacle crossing should be regarded when developing an intelligent WW.

  15. X-derived marker chromosome in patient with mosaic Turner syndrome and Dandy-Walker syndrome: a case report

    OpenAIRE

    Telepova, Alena S.; Romanenko, Svetlana A.; Lemskaya, Natalya A.; Maksimova, Yulia V.; Shorina, Asia R.; Yudkin, Dmitry V.

    2017-01-01

    Background Small supernumerary marker chromosomes can be derived from autosomes and sex chromosomes and can accompany chromosome pathologies, such as Turner syndrome. Case presentation Here, we present a case report of a patient with mosaic Turner syndrome and Dandy-Walker syndrome carrying a marker chromosome. We showed the presence of the marker chromosome in 33.8% of blood cells. FISH of the probe derived from the marker chromosome by microdissection revealed that it originated from the ce...

  16. GPS Imaging suggests links between climate, magmatism, seismicity, and tectonics in the Sierra Nevada-Long Valley Caldera-Walker Lane system, western United States

    Science.gov (United States)

    Hammond, W. C.; Blewitt, G.; Kreemer, C.; Smith, K.

    2017-12-01

    The Walker Lane is a region of complex active crustal transtension in the western Great Basin of the western United States, accommodating about 20% of the 50 mm/yr relative motion between the Pacific and North American plates. The Long Valley caldera lies in the central Walker Lane in eastern California, adjacent to the eastern boundary of the Sierra Nevada/Great Valley microplate, and experiences intermittent inflation, uplift, and volcanic unrest from the magma chamber that resides at middle crustal depths. Normal and transform faults accommodating regional tectonic transtension pass by and through the caldera, complicating the interpretation of the GPS-measured strain rate field, estimates of fault slip rates, and seismic hazard. Several dozen continuously recording GPS stations measure strain and uplift in the area with mm precision. They observe that the most recent episode of uplift at Long Valley began in mid-2011, continuing until late 2016, raising the surface by 100 mm in 6 years. The timing of the initiation of uplift coincides with the beginning of severe drought in California. Furthermore, the timing of a recent pause in uplift coincides with the very wet 2016-2017 winter, which saw approximately double normal snow pack. In prior studies, we showed that the timing of changes in geodetically measured uplift rate of the Sierra Nevada coincides with the timing of drought conditions in California, suggesting a link between hydrological loading and Sierra Nevada elevation. Here we take the analysis three steps further to show that changes in Sierra Nevada uplift rate coincide in time with 1) enhanced inflation at the Long Valley caldera, 2) shifts in the patterns and rates of horizontal tensor strain rate, and 3) seismicity patterns in the central Walker Lane. We use GPS solutions from the Nevada Geodetic Laboratory and the new GPS Imaging technique to produce robust animations of the time variable strain and uplift fields. The goals of this work are to

  17. Prissy’s Quittin’ Time: The Black Camp Aesthetics of Kara Walker

    Directory of Open Access Journals (Sweden)

    Stephens Brian

    2017-12-01

    Full Text Available Through a close reading of Walker’s first silhouette instalment-the audaciously titled Gone, An Historical Romance of a Civil War as it Occurred Between the Dusky Thighs of One Young Negress and Her Heart (1994-this article examines how Walker utilises black camp to undermine both white supremacist and restrictive black uplift discourse. To be sure, the article is not an attempt to conflate these two, for the former is powerfully worse than the latter. However, it is necessary to explore how both discourses reinforce essentialist articulations of blackness and also to examine how black camp is a provocative analytic for their simultaneous disruption. Camp is usually understood as a queer-derived cultural practice that inflates identity to expose the constructed nature of gender. However, this article shows that black articulations of camp inflate identity to demonstrate the fiction of race as well.

  18. Lanczos potentials and a definition of gravitational entropy for perturbed Friedman-Lemaitre-Robertson-Walker spacetimes

    International Nuclear Information System (INIS)

    Mena, Filipe C; Tod, Paul

    2007-01-01

    We give a prescription for constructing a Lanczos potential for a cosmological model which is a purely gravitational perturbation of a Friedman-Lemaitre-Robertson-Walker spacetime. For the radiation equation of state, we find the Lanczos potential explicitly via Fourier transforms. As an application, we follow up a suggestion of Penrose (1979 Singularities and time-asymmetry General Relativity: An Einstein Centenary Survey ed S W Hawking and W Israel (Cambridge: Cambridge University Press)) and propose a definition of gravitational entropy for these cosmologies. With this definition, the gravitational entropy initially is finite if and only if the initial Weyl tensor is finite

  19. Rates and timing of vertical-axis block rotations across the Sierra Nevada-Walker Lane transition in the Bodie Hills

    Science.gov (United States)

    Rood, D. H.; Herman, S.; Burbank, D.; Bogue, S.

    2008-12-01

    We use paleomagnetic data from Tertiary volcanic rocks to address the rates and timing of vertical-axis block rotation across the Sierra Nevada-Walker Lane transition in the Bodie Hills, California/Nevada. In zones of continental deformation, block rotations are an important mechanism for permanent stain accommodation, and thus may be crucial to testing geodetic block models and resolving geologic-geodetic slip discrepancies. In our study, data included in the paleomagetic site means are high quality AF demagnetization results (least squared fits that generally include 5-7 points with MAD values less than 1). Thermal demagnetization results match the AF directions, and both thermal demag and rockmag results indicate strong ChRM, mostly carried by single domain magnetite. The site means used to calculate the VGPs all have a95 values less than 10 (mostly 2-5) and include 6-11 sites each. Each site (and thus site mean) has a reasonably well-known structural correction. The VGP scatter values range from 12 to 16 degrees, indicating that they include appropriate secular variation. The mean declinations and 95 percent confidence limits for each VGP timeslice are statistically distinct from one another (71 ± 9, 39 ± 13, and 11 ± 11 degrees). The slope of a linear regression fit to the age versus declination data gives a rate of vertical axis block rotation of approximately 3-4 degrees/Myr. Fitting two separate lines to the age vs. declination data would indicate an increase in the rates of rotation since ~10 Ma. Two possible interpretations of the data are: (1) the rotations began during or before the Middle Miocene, or (2) rates of rotation were high initially (e.g. ~10 Ma) and decelerated until the Pliocene. These data have implications for the (1) timing and spatial extent of distributed strain accumulation related to the initiation of the San Andreas Fault-Eastern California Shear Zone-Walker Lane transform plate boundary, (2) transfer of transform plate boundary

  20. Computed tomography in the assessment of idiopathic spontaneous pneumothorax

    International Nuclear Information System (INIS)

    Kim, Sang Jin; Lee, Doo Yun; Kim, Hyung Jung

    1991-01-01

    It is well known that idiopathic spontaneous pneumothorax is caused by rupture of the subpleural bleb and presents difficulty in exact detection and localization of the bleb with plain chest X - ray alone. The authors performed chest CT scans for accurate diagnosis of bleb that would act as a guide for optimal management of idiopathic spontaneous pneumothorax patients in order to prevent recurrent pneumothorax. We could detect blebs in 93 % (26/28) of the patients with idiopathic spontaneous pneumothorax, and 68 % (19/ 28) of the patient had bilateral blebs. Sensitivity was 0.63, and false negative was 37% (37/100) of the blebs, and 51% (19/37) of these 37 false negative cases were ruptured blebs. Only 7 % (2/28) of the patients had a single bleb. The authors concluded that CT is a useful method of study for optimal management of idiopathic spontaneous pneumothorax patients

  1. Bound states for a neutral particle analogous to a quantum dot induced by the non-inertial effects of the Fermi-Walker reference frame

    International Nuclear Information System (INIS)

    Bakke, Knut

    2010-01-01

    We study the appearance of bound states analogous to a quantum dot, proposed by Tan and Inkson (1996) , in the non-relativistic quantum dynamics of a neutral particle with permanent magnetic dipole moment induced by the non-inertial effects of the Fermi-Walker reference frame.

  2. Effects of fast neutrons on chromatin: dependence on chromatin structure

    Energy Technology Data Exchange (ETDEWEB)

    Radu, L. [Dept. of Molecular Genetics, V. Babes National Inst., Bd. Timisoara, Bucharest (Romania); Constantinescu, B. [Dept. of Cyclotron, H. Hulubei National Inst., Bucharest (Romania); Gazdaru, D. [Dept. of Biophysics, Physics Faculty, Univ. of Bucharest (Romania)

    2002-07-01

    The effects of fast neutrons (10-100 Gy) on chromatin extracted from normal (liver of Wistar rats) and tumor (Walker carcinosarcoma maintained on Wistar rats) tissues were compared. The spectroscopic assays used were (i) chromatin intrinsic fluorescence, (ii) time-resolved fluorescence of chromatin-proflavine complexes, and (iii) fluorescence resonance energy transfer (FRET) between dansyl chloride and acridine orange coupled to chromatin. For both normal and tumor chromatin, the intensity of intrinsic fluorescence specific for acidic and basic proteins decreased with increasing dose. The relative contributions of the excited-state lifetime of proflavine bound to chromatin were reduced upon fast-neutron irradiation, indicating a decrease in the proportion of chromatin DNA available for ligand binding. The Forster energy transfer efficiencies were also modified by irradiation. These effects were larger for chromatin from tumor tissue. In the range 0-100 Gy, fast neutrons induced alterations in DNA and acidic and basic proteins, as well as in global chromatin structure. The radiosensitivity of chromatin extracted from tumor tissue seems to be higher than that of chromatin extracted from normal tissue, probably because of its higher euchromatin (loose)-heterochromatin (compact) ratio. (author)

  3. Effects of fast neutrons on chromatin: dependence on chromatin structure

    International Nuclear Information System (INIS)

    Radu, L.; Constantinescu, B.; Gazdaru, D.

    2002-01-01

    The effects of fast neutrons (10-100 Gy) on chromatin extracted from normal (liver of Wistar rats) and tumor (Walker carcinosarcoma maintained on Wistar rats) tissues were compared. The spectroscopic assays used were (i) chromatin intrinsic fluorescence, (ii) time-resolved fluorescence of chromatin-proflavine complexes, and (iii) fluorescence resonance energy transfer (FRET) between dansyl chloride and acridine orange coupled to chromatin. For both normal and tumor chromatin, the intensity of intrinsic fluorescence specific for acidic and basic proteins decreased with increasing dose. The relative contributions of the excited-state lifetime of proflavine bound to chromatin were reduced upon fast-neutron irradiation, indicating a decrease in the proportion of chromatin DNA available for ligand binding. The Forster energy transfer efficiencies were also modified by irradiation. These effects were larger for chromatin from tumor tissue. In the range 0-100 Gy, fast neutrons induced alterations in DNA and acidic and basic proteins, as well as in global chromatin structure. The radiosensitivity of chromatin extracted from tumor tissue seems to be higher than that of chromatin extracted from normal tissue, probably because of its higher euchromatin (loose)-heterochromatin (compact) ratio. (author)

  4. Relationship between strains of tumor-bearing animals and the tumor affinity of /sup 169/Yb and /sup 67/Ga

    Energy Technology Data Exchange (ETDEWEB)

    Ando, A; Hiraki, T [Kanazawa Univ. (Japan). School of Paramedicine; Hisada, K; Ando, I; Ugiie, T

    1975-02-01

    It is well a well-known fact that ytterbium-169 is a strong bone seeking element. We have already reported that this element was concentrated in nonosseous tumor tissues and that its tumor affinity was stronger than that of gallium-67 in our previous experiment using Yoshida sarcoma-bearing rats. Ytterbium-169 citrate and gallium-67 citrate were compared in four strains of tumor-bearing rats and mice. The uptake rate of ytterbium-169 in tumor tissues was much larger than that of gallium-67 in Ehrlich cancer-bearing mice, but these values of ytterbium-169 were slightly smaller than those of gallium-67 in Yoshida sarcoma-bearing rats, Walker carcinosarcoma 256-bearing rats and sarcoma 180-bearing mice. Tumor to organ ratios of ytterbium-169, which were most important for tumor scanning agents, were much larger than those of gallium-67 in all four strains except for the tumor to bone ratio of ytterbium-169. From the above-described facts, it was shown that ytterbium-169 citrate had a stronger tumor affinity than did gallium-67 citrate and that the tumor affinity of ytterbium-169 citrate was similar in each of these four strains of tumor-bearing animals.

  5. Corrected entropy of Friedmann-Robertson-Walker universe in tunneling method

    International Nuclear Information System (INIS)

    Zhu, Tao; Ren, Ji-Rong; Li, Ming-Fan

    2009-01-01

    In this paper, we study the thermodynamic quantities of Friedmann-Robertson-Walker (FRW) universe by using the tunneling formalism beyond semiclassical approximation developed by Banerjee and Majhi [25]. For this we first calculate the corrected Hawking-like temperature on apparent horizon by considering both scalar particle and fermion tunneling. With this corrected Hawking-like temperature, the explicit expressions of the corrected entropy of apparent horizon for various gravity theories including Einstein gravity, Gauss-Bonnet gravity, Lovelock gravity, f(R) gravity and scalar-tensor gravity, are computed. Our results show that the corrected entropy formula for different gravity theories can be written into a general expression (4.39) of a same form. It is also shown that this expression is also valid for black holes. This might imply that the expression for the corrected entropy derived from tunneling method is independent of gravity theory, spacetime and dimension of the spacetime. Moreover, it is concluded that the basic thermodynamical property that the corrected entropy on apparent horizon is a state function is satisfied by the FRW universe

  6. Characterization of the damage of Spodoptera eridania (Cramer) and Spodoptera cosmioides (Walker) (Lepidoptera: Noctuidae) to structures of cotton plants

    OpenAIRE

    Santos, Karen B dos; Meneguim, Ana M; Santos, Walter J dos; Neves, Pedro M O J; Santos, Rachel B dos

    2010-01-01

    The cotton plant, Gossypium hirsutum, hosts various pests that damage different structures. Among these pests, Spodoptera cosmioides (Walker) and Spodoptera eridania (Cramer) (Lepidoptera: Noctuidae) are considered important. The objectives of this study were to characterize and to quantify the potential damage of S. eridania and S. cosmioides feeding on different structures of cotton plants. For this purpose, newly-hatched larvae were reared on the following plant parts: leaf and flower bud;...

  7. Review of the East Palaearctic and North Oriental Psyttalia Walker, with the description of three new species (Hymenoptera, Braconidae, Opiinae).

    Science.gov (United States)

    Wu, Qiong; van Achterberg, Cornelis; Tan, Jiang-Li; Chen, Xue-Xin

    2016-01-01

    The East Palaearctic and North Oriental species of the genus Psyttalia Walker (Hymenoptera, Braconidae, Opiinae) are reviewed. Three new species are described and illustrated: Psyttalia latinervis Wu & van Achterberg, sp. n . and Psyttalia majocellata Wu & van Achterberg, sp. n . from China, and Psyttalia spectabilis van Achterberg, sp. n. from Japan. Coeloreuteus formosanus Watanabe, 1934, Opius (Lissosema) proclivis Papp, 1981, Opius (Psyttalia) subcyclogaster Tobias, 1998, Opius (Psyttalia) darasunicus Tobias, 1998, Opius (Psyttalia) cyclogastroides Tobias, 1998, Psyttalia extensa Weng & Chen, 2001, and Rhogadopsis longicaudifera Li & van Achterberg, 2013, are new synonyms of Psyttalia cyclogaster (Thomson, 1895); Opius (Psyttalia) ophthalmicus Tobias, 1977, and Opius (Psyttalia) brevitemporalis Tobias, 1998, of Psyttalia carinata (Thomson, 1895) and both Opius (Psyttalia) vacuus Tobias, 1998, and Opius (Lissosema) longurius Chen & Weng, 1995, of Rhogadopsis mediocarinata (Fischer, 1963). Phaedrotoma daghestanicum (Telenga, 1950), Rhogadopsis mediocarinata (Fischer, 1963) and Rhogadopsis mystica (Fischer, 1963) are new combinations. New records are Psyttalia carinata (Thomson, 1895) from The Netherlands and Norway, and Psyttalia cyclogaster (Thomson, 1895) from Japan. A lectotype is designated for Psyttalia carinata (Thomson, 1895) and Psyttalia cyclogaster (Thomson, 1895). A key to the East Palaearctic and North Oriental species of the genus Psyttalia Walker is included.

  8. Review of the East Palaearctic and North Oriental Psyttalia Walker, with the description of three new species (Hymenoptera, Braconidae, Opiinae

    Directory of Open Access Journals (Sweden)

    Qiong Wu

    2016-11-01

    Full Text Available The East Palaearctic and North Oriental species of the genus Psyttalia Walker (Hymenoptera, Braconidae, Opiinae are reviewed. Three new species are described and illustrated: P. latinervis Wu & van Achterberg, sp. n. and P. majocellata Wu & van Achterberg, sp. n. from China, and P. spectabilis van Achterberg, sp. n. from Japan. Coeloreuteus formosanus Watanabe, 1934, Opius (Lissosema proclivis Papp, 1981, O. (Psyttalia subcyclogaster Tobias, 1998, O. (P. darasunicus Tobias, 1998, O. (P. cyclogastroides Tobias, 1998, Psyttalia extensa Weng & Chen, 2001, and Rhogadopsis longicaudifera Li & van Achterberg, 2013, are new synonyms of Psyttalia cyclogaster (Thomson, 1895; Opius (Psyttalia ophthalmicus Tobias, 1977, and O. (P. brevitemporalis Tobias, 1998, of Psyttalia carinata (Thomson, 1895 and both O. (P. vacuus Tobias, 1998, and O. (Lissosema longurius Chen & Weng, 1995, of Rhogadopsis mediocarinata (Fischer, 1963. Phaedrotoma daghestanicum (Telenga, 1950, Rhogadopsis mediocarinata (Fischer, 1963 and R. mystica (Fischer, 1963 are new combinations. New records are Psyttalia carinata (Thomson, 1895 from The Netherlands and Norway, and P. cyclogaster (Thomson, 1895 from Japan. A lectotype is designated for Psyttalia carinata (Thomson, 1895 and P. cyclogaster (Thomson, 1895. A key to the East Palaearctic and North Oriental species of the genus Psyttalia Walker is included.

  9. From precocious fame to mature obscurity: David Walker (1837-1917) MD, LRCSI, surgeon and naturalist to the Fox Arctic Expedition of 1857-59.

    Science.gov (United States)

    Froggatt, Peter; Walker, Brian M

    2012-11-01

    The Belfast-born David Walker was the 19-year-old surgeon and naturalist on the epic Fox Arctic Expedition (1857-59) that established the fate of Sir John Franklin's unsuccessful (1845) search for the North-West Passage. On return the crew were fêted as heroes and decorated, and shared in a £5000 government bounty: Walker was also received by the Queen and (in Ireland) by the Lord Lieutenant, was honoured by the principal British and Irish natural history societies and his portrait was exhibited in the National Portrait Gallery, London. This paper describes his adventurous life, including the Fox Expedition, which from 1862 was spent abroad and included time in the Cariboo gold fields, service in the United States Army, practice in a notorious Californian frontier town and, in later life, the comparative quiet of general and occupational medical practice in Portland, Oregon. Once a household name, his death went unrecorded in the British and Irish medical and lay press.

  10. Scanning Electron Microscopy Study of the Antennal Sensilla of Monema flavescens Walker (Lepidoptera: Limacodidae).

    Science.gov (United States)

    Yang, S; Liu, H; Zhang, J T; Liu, J; Zheng, H; Ren, Y

    2017-04-01

    Monema flavescens Walker (Lepidoptera: Limacodidae) is a serious polyphagous defoliator. Using scanning electron microscopy, the external morphology of the antennal sensilla of this pest was examined for a better understanding of the mechanisms of insect-insect and insect-plant chemical communications. The antennae of M. flavescens were filiform in shape, and 11 morphological types of sensilla were found in both sexes. Six types of likely chemosensory sensilla were identified: uniporous sensilla chaetica, multiporous sensilla trichodea, and four types of multiporous sensilla basiconica. The sensilla identified as likely mechanoreceptors included two subtypes of aporous sensilla chaetica, aporous sensilla coeloconica, aporous sensilla styloconica, and Böhm's bristles, whereas the position of the antennae was monitored by Böhm's bristles.

  11. On defects of the volume and curvature of the Robertson-Walker metric and construction of cosmological models

    International Nuclear Information System (INIS)

    Gackstatter, F.

    1987-01-01

    For the Robertson-Walker metric (RWM) normal coordinates are constructed and the Riemann curvature tensor is determined. Then results on the defects of the volume and curvature, derived formerly, are applied to the RWM and to cosmological models. Finally cosmological models are constructed, they describe different states of the development of the cosmos: p ∼ 0, 1/3u, 2/3u, in a unified form. A Laurent expansion of the density of energy u and pressure p is used to solve the Friedmann equations. (author)

  12. Planning and Execution of a Marine Methane Hydrate Pressure Coring Program for the Walker Ridge and Green Canyon Areas of the Gulf of Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Humphrey, Gary [Fugro Geoconsulting Inc., Houston, TX (United States)

    2015-09-14

    The objective of this project (and report) is to produce a guide to developing scientific, operational, and logistical plans for a future methane hydrate-focused offshore pressure coring program. This report focuses primarily on a potential coring program in the Walker Ridge 313 and Green Canyon 955 blocks where previous investigations were undertaken as part of the 2009 Department of Energy JIP Leg II expedition, however, the approach to designing a pressure coring program that was utilized for this project may also serve as a useful model for planning pressure coring programs for hydrates in other areas. The initial portion of the report provides a brief overview of prior investigations related to gas hydrates in general and at the Walker Ridge 313 and Green Canyon 955 blocks in particular. The main content of the report provides guidance for various criteria that will come into play when designing a pressure coring program.

  13. Disparate requirements for the Walker A and B ATPase motifs ofhuman RAD51D in homologous recombination

    Energy Technology Data Exchange (ETDEWEB)

    Wiese, Claudia; Hinz, John M.; Tebbs, Robert S.; Nham, Peter B.; Urbin, Salustra S.; Collins, David W.; Thompson, Larry H.; Schild, David

    2006-04-21

    In vertebrates, homologous recombinational repair (HRR) requires RAD51 and five RAD51 paralogs (XRCC2, XRCC3, RAD51B, RAD51C, and RAD51D) that all contain conserved Walker A and B ATPase motifs. In human RAD51D we examined the requirement for these motifs in interactions with XRCC2 and RAD51C, and for survival of cells in response to DNA interstrand crosslinks. Ectopic expression of wild type human RAD51D or mutants having a non-functional A or B motif was used to test for complementation of a rad51d knockout hamster CHO cell line. Although A-motif mutants complement very efficiently, B-motif mutants do not. Consistent with these results, experiments using the yeast two- and three-hybrid systems show that the interactions between RAD51D and its XRCC2 and RAD51C partners also require a functional RAD51D B motif, but not motif A. Similarly, hamster Xrcc2 is unable to bind to the non-complementing human RAD51D B-motif mutants in co-immunoprecipitation assays. We conclude that a functional Walker B motif, but not A motif, is necessary for RAD51D's interactions with other paralogs and for efficient HRR. We present a model in which ATPase sites are formed in a bipartite manner between RAD51D and other RAD51 paralogs.

  14. Cell shape and organelle modification in apoptotic U937 cells

    Directory of Open Access Journals (Sweden)

    MR Montinari

    2009-12-01

    Full Text Available U937 cells induced to apoptosis, progressively and dramatically modified their cell shape by intense blebbing formation, leading to the production of apoptotic bodies. The blebs evolved with time; milder forms of blebbing involving only a region or just the cortical part of the cytoplasm were observed within the first hour of incubation with puromycin; blebbing involving the whole cell body with very deep constrictions is the most frequent event observed during late times of incubation. The ultrastructural analysis of apoptotic cells revealed characteristic features of nuclear fragmentation (budding and cleavage mode and cytoplasmatic modifications. The cytoplasm of blebs does not contain organelles, such as ribosomes or mitochondria. Scarce presence of endoplasmic reticulum can be observed at the site of bleb detachment. However, blebbing is a dispensable event as evaluated by using inhibitor of actin polymerization. In the present study, the progressive modifications of the nucleus, mitochondria, nuclear fragmentation, cytoplasmic blebs formation and production of apoptotic bodies in U937 monocytic cells induced to apoptosis by puromycin (an inhibitor of protein synthesis were simultaneously analyzed.

  15. An Architect Cicada in Brazilian Rainforest: Guyalna chlorogena (Walker).

    Science.gov (United States)

    Béguin, C F

    2017-04-01

    To study the noteworthy nest building behavior of the nymph of the Brazilian Rainforest cicada Guyalna chlorogena (Walker) during the last year of its underground life, we monitored a large number of edifices, consisting of a vertical well (up to 1 m deep) with a turret (20 to 40 cm tall) on top, and we also performed experiments. We have shown that the buildings are occupied by a single nymph, male or female, which increases the height of its turret each night by about 3 cm, during a short active growing phase. The nymph softens and reshapes the apex by pushing upwards a lump of freshly mixed soaked clay, without any opening present, i. e., without ever exposing itself to the outside. We also established that the nymph is very active once its building is achieved. For example, it restores the height of the turret to its original value when shortening and opens the top of its building in case of variation of environmental parameters. Finally, we have shown how the nymph opens its edifice to reach the outside for molting into an adult stage (imago). With this work, we contributed to a better understanding of the nesting behavior of Amazon cicadas.

  16. A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction.

    Science.gov (United States)

    Zhang, Jing; Wang, Liang-Liang; Hou, Mei-Feng; Xia, Yao-Kun; He, Wen-Hui; Yan, An; Weng, Yun-Ping; Zeng, Lu-Peng; Chen, Jing-Hua

    2018-04-15

    Sensitive and selective detection of microRNAs (miRNAs) in cancer cells derived exosomes have attracted rapidly growing interest owing to their potential in diagnostic and prognostic applications. Here, we design a ratiometric electrochemical biosensor based on bipedal DNA walkers for the attomolar detection of exosomal miR-21. In the presence of miR-21, DNA walkers are activated to walk continuously along DNA tracks, resulting in conformational changes as well as considerable increases of the signal ratio produced by target-respond and target-independent reporters. With the signal cascade amplification of DNA walkers, the biosensor exhibits ultrahigh sensitivity with the limit of detection (LOD) down to 67 aM. Furthermore, owing to the background-correcting function of target-independent reporters termed as reference reporters, the biosensor is robust and stable enough to be applied in the detection of exosomal miR-21 extracted from breast cancer cell lines and serums. In addition, because locked nucleic acid (LNA) modified toehold mediate strand displacement reaction (TMSDR) has extraordinary discriminative ability, the biosensor displays excellent selectivity even against the single-base-mismatched target. It is worth mentioning that our sensor is regenerative and stable for at least 5 cycles without diminution in sensitivity. In brief, the high sensitivity, selectivity and reproducibility, together with cheap, make the proposed biosensor a promising approach for exosomal miRNAs detection, in conjunction with early point-of-care testing (POCT) of cancer. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Die Silhouette in der zeitgenössischen Kunst: Vergegenwärtigung und Bewältigung in Kara Walkers "Slavery! Slavery!"

    OpenAIRE

    Haarer, Andrea

    2012-01-01

    Lotte Reinigers Silhouettenfilme nutzten mediale Eigenschaften von Abstraktion und Imagination sowie kulturelle Kodes als visuelle Strategie, um bekannte Geschichten bildlich zu kommentieren und andersartig zu erzählen. Kara Walker setzt diese Strategie bildlichen Erzählens in der zeitgenössischen Kunst fruchtbar fort. Ihre großformatigen Silhouetten machen in "Slavery! Slavery!" (1997) die Schwierigkeit sichtbar, eine afroamerikanische Geschichte zu erzählen, die nicht von Mythen und Stereot...

  18. Prof. John Wood, Chief Executive Designate, Dr Gordon Walker, Directorate, Chief Executive, Prof. Ken J. Peach, Head of the Particle Physics Department, CLRC Rutherford Appleton Laboratory, United Kingdom

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    L. to. r.: Dr. Ian Wilson, CLIC Deputy Study Leader, Prof. Ken J. Peach, Head of the Particle Physics Department, Prof. John Wood, Chief Executive Designate, Dr. Gordon Walker, Directorate, Chief Executive

  19. A Kinematic Model for Vertical Axis Rotation within the Mina Deflection of the Walker Lane

    Science.gov (United States)

    Gledhill, T.; Pluhar, C. J.; Johnson, S. A.; Lindeman, J. R.; Petronis, M. S.

    2016-12-01

    The Mina Deflection, at the boundary between the Central and Southern Walker Lane, spans the California-Nevada border and includes a heavily-faulted Pliocene volcanic field overlying Miocene ignimbrites. The dextral Walker Lane accommodates 25% of relative Pacific-North America plate motion and steps right across the sinistral Mina deflection. Ours and previous work shows that the Mina Deflection partially accommodates deformation by vertical-axis rotation of up to 99.9o ± 6.1o rotation since 11 Ma. This rotation is evident in latite ignimbrite of Gilbert et al. (1971), which we have formalized as three members of Tuff of Huntoon Creek (THC). The welded, basal, normal-polarity Huntoon Valley Member of THC is overlain by the unwelded to partially-welded, reversed-polarity Adobe Hills Mbr. This member includes internal breaks suggesting multiple eruptive phases, but the paleomagnetic results from each are statistically indistinguishable, meaning that they were likely erupted in rapid succession (within a few centuries of one another). THC ends with a welded member exhibiting very shallow inclination and south declination that we call Excursional Mbr. One of the upper members has been dated at 11.17 ± 0.04 Ma. These Miocene units are overlain by Pliocene basalts, Quaternary alluvium, and lacustrine deposits. Our paleomagnetic results show a gradient between the zero rotation domain and high rotation across a 20km baseline. A micropolar model, based on 25 years of earthquake data from the Northern and Southern California Seismic Network, suggest the Mina Deflection is currently experiencing transpressional seismogenic deformation (Unruh et al., 2003). Accepting Unruh's model and assuming continuous rotation since 11 Ma, we propose a kinematic model for the western Mina Deflection that accommodates 90o of vertical axis rotation from N-S to ENE-WSW oriented blocks.

  20. Homologous Type of Malignant Mixed Mullerian Tumor of the Uterus Presenting as a Cervical Mass

    Directory of Open Access Journals (Sweden)

    Umur Kuyumcuoğlu

    2009-10-01

    Full Text Available Malignant mixed Mullerian tumors are composed of a mixture of sarcoma and carcinoma. The carcinomatous element is usually glandular, whereas the sarcomatous element may resemble normal endometrial stroma (homologous or so-called carcinosarcoma. Here, we present a homologous type of malignant mixed Mullerian tumor of the uterus that presented as a cervical mass. We describe a 55-year-old patient who had a cervical mass arising from the uterus. We performed total abdominal hysterectomy and bilateral salpingo-oophorectomy and surgical staging (including (peritoneal washings, suspicious areas or peritoneal surfaces sampled, infracolic omental sampling, pelvic and paraaortic lymph node sampling, and appendectomy. Carcinosarcomas of the uterine cervix are extremely rare, and when a post-menopausal woman with a cervical mass is admitted to the gynecology clinic, the physician should keep in mind that the mass might be a carcinosarcoma. [J Chin Med Assoc 2009;72(10:533–535

  1. Kinetic analysis of the function of the upper body for elite race walkers during official men 20 km walking race.

    Science.gov (United States)

    Hoga-Miura, Koji; Ae, Michiyoshi; Fujii, Norihisa; Yokozawa, Toshiharu

    2016-10-01

    This study investigated the function of the upper extremities of elite race walkers during official 20 km races, focusing on the angular momentum about the vertical axis and other parameters of the upper extremities. Sixteen walkers were analysed using the three-dimensional direct linear transformation method during three official men's 20 km walking races. The subjects, included participants at the Olympics and World Championships, who finished without disqualification and had not been disqualified during the two years prior to or following the races analysed in the present study. The angular momenta of the upper and lower body were counterbalanced as in running and normal walking. The momentum of the upper body was mainly generated by the upper extremities. The joint force moment of the right shoulder and the joint torque at the left shoulder just before right toe-off were significantly correlated with the walking speed. These were counterbalanced by other moments and torques to the torso torque, which worked to obtain a large mechanical energy flow from the recovery leg to the support leg in the final phase of the support phase. Therefore, a function of the shoulder torque was to counterbalance the torso torque to gain a fast walking speed with substantial mechanical energy flow.

  2. Interactions of ozone and antineoplastic drugs on rat lung fibroblasts and Walker rat carcinoma cells

    International Nuclear Information System (INIS)

    Wenzel, D.G.; Morgan, D.L.

    1983-01-01

    Cultured rat lung fibroblasts (F-cells) and Walker rat carcinoma cells (WRC-cells) labeled with 51 Cr were exposed to the following antitumor drugs alone or with O 3 : carmustine (BCNU), doxorubicin (Dox), cisplatin (CPt), mitomycin C (Mit C) or vitamin K 3 (Vit K). Release of 51 Cr (cell injury) was greater for F-cells than WRC-cells with any single treatment. Pretreatment with any drug (400 microM), except for Vit K with WRC-cells, did not significantly increase O 3 -induced loss of 51 Cr. Co-exposure of F-cells to drugs and O 3 resulted in a marked potentiation of O 3 -induced injury with Vit K, and an inhibition with Dox

  3. NMR images of non-communicating hydrocephalus associated with Dandy-Walker variant and achondroplasia

    International Nuclear Information System (INIS)

    Sato, Masaharu; Kuroda, Ryotaro; Watanabe, Masaru; Nakatani, Jiro; Ioku, Masahiko; Irisawa, Minoru; Hamada, Tatsumi; Ishida, Osamu

    1988-01-01

    Two cases of non-communicating hydrocephalus caused by a relatively rare etiology were reported. They were both diagnosed by means of nuclear magnetic resonance (NMR). The first patient, a 4-month-old boy, had Dandy-Walker variant, showing hypoplasia of the corpus callosum and the inferior vermis, and a large cyst behind the vermis, communicating with the subarachnoid space, as well as hydrocephalus; the fourth ventricle was partially reserved. The second patient, also a 4-month-old boy, had achondroplasia, resulting in a narrow foramen magnum; the disturbance of the outflow of the cerebro-spinal fluid around the cisterna magna was thought to be the cause of hydrocephalus in his case. The validity of NMR was demonstrated in the diagnoses of these conditions, for a high resolution was needed in examining the complicated structure of the posterior fossa. (author)

  4. NMR images of non-communicating hydrocephalus associated with Dandy-Walker variant and achondroplasia

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Masaharu; Kuroda, Ryotaro; Watanabe, Masaru; Nakatani, Jiro; Ioku, Masahiko; Irisawa, Minoru; Hamada, Tatsumi; Ishida, Osamu

    1988-06-01

    Two cases of non-communicating hydrocephalus caused by a relatively rare etiology were reported. They were both diagnosed by means of nuclear magnetic resonance (NMR). The first patient, a 4-month-old boy, had Dandy-Walker variant, showing hypoplasia of the corpus callosum and the inferior vermis, and a large cyst behind the vermis, communicating with the subarachnoid space, as well as hydrocephalus; the fourth ventricle was partially reserved. The second patient, also a 4-month-old boy, had achondroplasia, resulting in a narrow foramen magnum; the disturbance of the outflow of the cerebro-spinal fluid around the cisterna magna was thought to be the cause of hydrocephalus in his case. The validity of NMR was demonstrated in the diagnoses of these conditions, for a high resolution was needed in examining the complicated structure of the posterior fossa.

  5. Effects of Walker 256 carcinoma on metabolic alterations during the evolution of pregnancy.

    Science.gov (United States)

    Cintra-Gomes, M C; Cury, L; Parreira, M R; Elias, C F; Areas, M A

    1990-01-01

    The control of pregnant cancer patients is difficult because it involves both mother and fetus, and the metabolic alterations in the cancer host induce a massive mobilization of nutrients diverted to the neoplastic cells. The purpose of the present study was to determine the evolution of the Walker 256 carcinoma in pregnant rats and its consequences on fetal development. The results showed that the tumors displayed a very rapid rate of growth and induced a reduction in fetal weights in the pregnant tumor-bearing rats. The tumor-bearing and pregnant tumor-bearing groups showed a decrease in blood glucose and total serum protein, suggesting an increase in energy utilization of these substrates and synthetic activity by the tumoral cells. An imbalance between protein synthesis and catabolism may occur in the tumor-bearing rats which may be related to the degree of nutritional depletion.

  6. Morphology-Controlled 9,10-Diphenylanthracene Nanoblocks as Electrochemiluminescence Emitters for MicroRNA Detection with One-Step DNA Walker Amplification.

    Science.gov (United States)

    Liu, Jia-Li; Tang, Zhi-Ling; Zhang, Jia-Qi; Chai, Ya-Qin; Zhuo, Ying; Yuan, Ruo

    2018-04-17

    The electrochemiluminescence (ECL) properties of polycyclic aromatic hydrocarbons (PAHs) are excellent on account of the high photoluminescence quantum yield. However, the poor solubility and radical instability of PAHs in the aqueous solution severely restricted further biological application. Here 9,10-diphenylanthracene (DPA) nanoblocks (NBs) with good dispersibility and stability in aqueous solution were prepared according to morphology-controlled technology employing water-soluble polymers as a protectant. Furthermore, an ECL "off-on" switch biosensor was developed based on a novel ECL ternary system with DPA NBs as luminophore, dissolved O 2 as coreactant, and Pt-Ag alloy nanoflowers as the coreaction accelerator, which achieved a high-intense initial ECL signal. Subsequently, the Fc-DNA as ECL signal quencher was assembled on the electrode surface to quench the initial ECL signal for a "signal-off" state. Meanwhile, DNA swing arm was modified on the electrode surface for one-step DNA walker amplification. Interestingly, in the presence of miRNA-141 and T7 Exo, the one-step DNA walker amplification was executed to recover a strong ECL signal as a "signal-on" state by the digestion of Fc-DNA. Thus the developed ECL "off-on" switch biosensor possesses a detection limit down to 29.5 aM for ultrasensitive detection of miRNA-141, which is expected to be applicable to the detection of miRNA in clinic tumor cells.

  7. Dispersion, Topological Scattering, and Self-Interference in Multiply Connected Robertson-Walker Cosmologies

    CERN Document Server

    Tomaschitz, R

    1994-01-01

    We investigate scattering effects in open Robertson-Walker cosmologies whose spacelike slices are multiply connected hyperbolic manifolds. We work out an example in which the 3-space is infinite and has the topology of a solid torus. The world-lines in these cosmologies are unstable, and classical probability densities evolving under the horospherical geodesic flow show dispersion, as do the densities of scalar wave packets. The rate of dispersion depends crucially on the expansion factor, and we calculate the time evolution of their widths. We find that the cosmic expansion can confine dispersion: The diameter of the domain of chaoticity in the 3-manifold provides the natural, time-dependent length unit in an infinite, multiply connected universe. In a toroidal 3-space manifold this diameter is just the length of the limit cycle. On this scale we find that the densities take a finite limit width in the late stage of the expansion. In the early stage classical densities and conformally coupled fields approach...

  8. Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination.

    Science.gov (United States)

    Wiese, Claudia; Hinz, John M; Tebbs, Robert S; Nham, Peter B; Urbin, Salustra S; Collins, David W; Thompson, Larry H; Schild, David

    2006-01-01

    In vertebrates, homologous recombinational repair (HRR) requires RAD51 and five RAD51 paralogs (XRCC2, XRCC3, RAD51B, RAD51C and RAD51D) that all contain conserved Walker A and B ATPase motifs. In human RAD51D we examined the requirement for these motifs in interactions with XRCC2 and RAD51C, and for survival of cells in response to DNA interstrand crosslinks (ICLs). Ectopic expression of wild-type human RAD51D or mutants having a non-functional A or B motif was used to test for complementation of a rad51d knockout hamster CHO cell line. Although A-motif mutants complement very efficiently, B-motif mutants do not. Consistent with these results, experiments using the yeast two- and three-hybrid systems show that the interactions between RAD51D and its XRCC2 and RAD51C partners also require a functional RAD51D B motif, but not motif A. Similarly, hamster Xrcc2 is unable to bind to the non-complementing human RAD51D B-motif mutants in co-immunoprecipitation assays. We conclude that a functional Walker B motif, but not A motif, is necessary for RAD51D's interactions with other paralogs and for efficient HRR. We present a model in which ATPase sites are formed in a bipartite manner between RAD51D and other RAD51 paralogs.

  9. Global bifurcation of solutions of the mean curvature spacelike equation in certain Friedmann-Lemaître-Robertson-Walker spacetimes

    Science.gov (United States)

    Dai, Guowei; Romero, Alfonso; Torres, Pedro J.

    2018-06-01

    We study the existence of spacelike graphs for the prescribed mean curvature equation in the Friedmann-Lemaître-Robertson-Walker (FLRW) spacetime. By using a conformal change of variable, this problem is translated into an equivalent problem in the Lorentz-Minkowski spacetime. Then, by using Rabinowitz's global bifurcation method, we obtain the existence and multiplicity of positive solutions for this equation with 0-Dirichlet boundary condition on a ball. Moreover, the global structure of the positive solution set is studied.

  10. Comparative management of Chilo suppressalis (Walker) (Lepidoptera: Crambidae) by convenient pesticides and non-chemical practices in a double rice cropping system

    OpenAIRE

    M. N. Poor Amiri; Faramarz Alinia; Sohrab Imani, et al.

    2017-01-01

    The inclination of rice growers towards double cropping system in north of Iran has raised new concerns about the excessive release of broad-spectrum pesticides, particularly organophosphates, in the environment. In this study, the efficiency of three insecticides and an integrated pest management (IPM) program for management of the striped rice stem borer, Chilo suppressalis (Walker) (Lep: Crambidae), in double cropping system was investigated under field condition. According to the results,...

  11. Obituary: Richard L. (Dick) Walker, Jr., 1938-2005

    Science.gov (United States)

    Pier, Jeffrey R.; Mason, Brian

    2005-12-01

    Dick Walker, 67, died 30 March 2005 in Flagstaff, AZ, following a long illness. He was born on 9 March 1938 in Hampton, Iowa and grew up in Waterloo, Iowa. As a child, Dick was fascinated with astronomy and built his own telescope. He saved his pennies and bought and read every book on the subject he could find. He also raised pigeons, naming four of them Hertzsprung, Hoyle, Gamow, and Kron. In 1957, the year Sputnik was launched, Dick began his college studies at the University of Northern Iowa in Cedar Falls. In 1959, he transferred to the State University of Iowa (subsequently renamed the University of Iowa) in Iowa City, where he earned a BA degree in astronomy and physics in 1963. He joined the staff of the U.S. Naval Observatory in Washington, DC, where he worked in the Time Service Division for a year before his assignment to the Astrometry and Astrophysics Division. Dick relocated to Flagstaff, AZ, in 1966 to continue his Naval Observatory service at the Flagstaff Station. His retirement in May 1999, ended a thirty-six-year career with USNO. Dick was first and foremost an observational astronomer. From the mid 1960s through the late 1970s, much of Dick's time was devoted to the measurement of binary stars, observing with the 12-inch and 26-inch refractors in Washington and later the 40-inch and 61-inch reflectors in Flagstaff. He also made many trips to Lick Observatory to work with the 36-inch Clark Refractor there. During this time he consulted with Charles Worley, who was observing on the 26-inch, to make sure time was well-spent examining doubles that could not be observed in Washington. This period of observing overlapped with the early years of speckle interferometry, and Dick's observations, made with the largest telescope used for micrometry at the time, were very important for ascertaining the veracity of this new technique. He was a studious and very careful observer of doubles and made over 8,000 measures, resulting in almost 3,000 mean positions

  12. Spectral-domain optical coherence tomography analysis of persistent subretinal fluid after scleral buckling surgery for macula-off retinal detachment

    Science.gov (United States)

    Gharbiya, M; Malagola, R; Mariotti, C; Parisi, F; De Vico, U; Ganino, C; Grandinetti, F

    2015-01-01

    Purpose To determine the predictive value of markers for persistent subretinal fluid (SRF) absorption and the influence of subfoveal fluid on visual outcome after scleral buckle (SB) surgery for rhegmatogenous retinal detachment (RRD). Patients and methods This was a retrospective, observational study. We reviewed the medical records of 64 eyes of 64 patients who underwent SB surgery for macula-off RRD. Patients underwent clinical examination and spectral-domain optical coherence tomography before surgery, at 1 month and every 3 months postoperatively. The height and width of SRF bleb(s) were measured over time. Results Persistent SRF at 1 month was observed in 40 eyes (62.5%). SRF blebs were first detected 1.7±2.2 months postoperatively. In 29 cases that could be fully followed up, SRF blebs were completely absorbed 7.8±4.4 months postoperatively. Resolution of fluid was associated with an improvement of VA (P=0.003). Serial measurements of SRF bleb size showed that bleb width decreased significantly at all time points during the 12-month follow-up period (P0.05). The cut-off value of the bleb width-to-height ratio level for predicting bleb absorption at 6 months was 7, with 89% sensitivity and 83% specificity. Conclusions Visual improvement may occur with late resolution of residual subfoveal fluid. A bleb width-to-height ratio >7 indicates a higher risk of SRF to persist beyond 6 months after surgery. PMID:26139048

  13. Kinematics of Deformation in West-Central Walker Lane; Paleomagnetic Testing of Fault-Block Rotation and Doming Models, Eastern California and Western Nevada

    Science.gov (United States)

    Fredrickson, S. M.; Pluhar, C. J.; Carlson, C. W.

    2013-12-01

    Walker Lane is a broad (~100-200 km) zone of dextral shear located between the Sierra Nevada microplate and the Basin and Range Province. We consider Bodie Hills a part of the greater Walker Lane because it has experienced clockwise, vertical-axis rotation of crustal blocks due to dextral shear accommodation. This strain is variable, resulting in rotations ranging from ~10°-70° depending on location. The Miocene Eureka Valley Tuff (EVT) is an ideal strain marker, because it is a geologically instantaneous and laterally extensive unit. We use paleomagnetic analysis of ignimbrites to improve the resolution of strain domain boundaries as well as test for doming in Bodie Hills. EVT site mean directions were compared to reference directions of the Tollhouse Flat and By Day Members collected from the stable Sierra Nevada to determine magnitudes of vertical-axis rotation. Three new sites and three previously sampled sites define a high-rotation domain including Bridgeport Valley and the East Walker River Canyon with an average clockwise rotation of ~50°-60°. We define the eastern boundary of this high-rotation domain as coinciding with a mapped fault exhibiting 11.7°×7.9° rotation of the presumed footwall. Our data corroborates and improves on Carlson's (2012) kinematic model in which the greater Bodie Hills has rotated clockwise ~30° since EVT emplacement. Eutaxitic textures, dipping up to 90°, are gross indicators of true tilt, but are also influenced by original dips in some localities, complicating interpretations. John et al. (2012) describe a simple doming model of Bodie Hills since EVT emplacement, supported by the high elevation of outflow channels compared to source areas. Our paleomagnetic data does not support simple doming, suggesting that there is either no doming of Bodie Hills, or that vertical crustal displacements have occurred without large-scale folding. John et al. (2012) dated undifferentiated EVT in Bodie Hills at ~9.4 Ma; using

  14. Path tracking control of an omni-directional walker considering pressures from a user.

    Science.gov (United States)

    Tan, Renpeng; Wang, Shuoyu; Jiang, Yinlai; Ishida, Kenji; Fujie, Masakatsu G

    2013-01-01

    An omni-directional walker (ODW) is being developed to support the people with walking disabilities to do walking rehabilitation. The training paths, which the user follows in the rehabilitation, are defined by physical therapists and stored in the ODW. In order to obtain a good training effect, the defined training paths need to be performed accurately. However, the ODW deviates from the training path in real rehabilitation, which is caused by the variation of the whole system's parameters due to the force from the user. In this paper, the characteristics of pressures from a user are measured, based on which an adaptive controller is proposed to deal with this problem, and validated in an experiment in which a pseudo handicapped person follows the ODW. The experimental results show that the proposed method can control the ODW to accurately follow the defined path with or without a user.

  15. Response to comment by Walker et al. on “From data to decisions: Processing information, biases, and beliefs for improved management of natural resources and environments”

    Science.gov (United States)

    Glynn, Pierre D.; Voinov, Alexey A.; Shapiro, Carl D.; White, Paul A.

    2018-01-01

    Our different kinds of minds and types of thinking affect the ways we decide, take action, and cooperate (or not). The comment by Walker et al. (2018, https://doi.org/10.1002/2017EF000750) illustrates several points made by Glynn et al. (2017, https://doi.org/10.1002/2016EF000487) and many other articles. Namely, biases and beliefs often drive scientific reasoning, and scientists, just like other humans, are intimately attached to their values and heuristics. Scientists, just like many other people, also tend to read and interpret text in ways that best match their individual perceptions of a problem or issue: in many cases paraphrasing and changing the meaning of what they read to better match their initial ideas. Walker et al. are doing interesting and important research on uncertainty. Nonetheless, they misinterpret the work, assumptions, and conclusions brought forth by Glynn et al. (2017, https://doi.org/10.1002/2016EF000487).

  16. Fourth annual Walker Branch Watershed research symposium: Program and abstracts

    International Nuclear Information System (INIS)

    1993-03-01

    The methods and concepts of watershed research, originally applied in an experimental or monitoring mode to relatively small catchments, are increasingly being used at larger scales and for specific applied problems. Research at Oak Ridge National Laboratory, the Tennessee Valley Authority, the US Forest Service, and other agencies and institutions participating in this symposium reflects research over a broad range of spatial scales that is being integrated through large-scale experiments along with computer modeling and graphical interfaces. These research projects address the basic atmospheric, geophysical, biogeochemical, and biological processes that regulate the responses of forested ecosystems to natural environmental variation and anthropogenic stresses. This symposium highlights the use of large-scale ecosystem experiments to address environmental issues of global concern. These experiments provide the only effective way to test models of ecosystem response that are based on the current state of knowledge of hydrology, biogeochemistry, plant physiology, and other ecosystem processes. Major environmental problems that are being addressed include acidic deposition and nitrogen loading (Bear Brook Watershed, Maine; and the Girdsjoen Covered Catchment, Sweden); climate warming (Soil Warming Experiment, Maine); and altered rainfall amounts (Savannah River Loblolly Pine Soil Water Manipulation and the Walker Branch Watershed Throughfall Displacement Experiment)

  17. Optical Coherence Tomography in an Infant with Walker-Warburg Syndrome

    Directory of Open Access Journals (Sweden)

    Natsuko Mano

    2015-06-01

    Full Text Available Purpose: Walker-Warburg syndrome (WWS is a type of congenital muscular dystrophy (CMD characterised by severe brain malformation, lissencephaly, and congenital eye abnormalities. Despite the coexistence of various eye abnormalities, results from optical coherence tomography (OCT in WWS have not previously been reported. We herein report specific OCT findings in an infant with WWS. Patients and Methods: The patient was a 14-day-old boy delivered by caesarean section at 38 weeks and 4 days of gestation and with a birth weight of 2,543 g. A cranial MRI showed lissencephaly, hydrocephalus, an encephalocele, and cerebellar hypoplasia, consistent with the diagnosis of WWS. Results: A bilateral ocular examination showed no abnormalities of the anterior eye segment. A fundus examination showed a persistent hyaloid artery in the vitreous cavity, a widespread loss of fundus pigmentation, transparent choroidal vessels (some choroidal vessel sections were visible, and the absence of a distinct macular reflex. OCT showed no foveal pit and an indistinct laminar structure of the retina. The infant subsequently developed congenital glaucoma and he then died of respiratory failure at the age of 8 months. Conclusions: WWS is associated with a high incidence of congenital eye abnormalities, and this infant showed findings consistent with WWS. OCT revealed a marked retinal dysplasia.

  18. Potential Positive Effects of Pesticides Application on (Walker (Lepidoptera: Insecta

    Directory of Open Access Journals (Sweden)

    Guo-Qing Yang

    2014-01-01

    Full Text Available In China, the pink stem borer (PSB Sesamia inferens (Walker (Lepidoptera: Noctuidae has become a rice pest in some rice-producing regions. The cause of this shift from secondary to major pest is unknown. The major purpose of this study was to examine the effect of five commonly used pesticides in rice fields on reproduction of PSB and on biochemical substances of rice plants. The results showed that the weight of pupae developed from 1st instar larvae treated with 2 mg/L triazophos and the number of eggs laid by emerged females from the treatment were significantly greater than those of the control, increasing by 26.2% and 47%, respectively. In addition, a nontarget insecticide, pymetrozine 100 mg/L, and a target insecticide, chlorantraniliprole 2 mg/L, stimulated reproduction of PSB. Biochemical measurement showed that foliar sprays of these pesticides resulted in significant reductions of contents of resistant substances, flavonoids and phenolic acids, in rice plants. For example, flavonoids and phenolic acids of rice plants treated with triazophos reduced by 48.5% and 22.4%, respectively, compared to the control. Therefore, we predicted that the application of some pesticides, eg triazophos and chlorantraniliprole, may be the cause of the increase in the population numbers of PSB in rice fields.

  19. Generalized Robertson-Walker Space-Time Admitting Evolving Null Horizons Related to a Black Hole Event Horizon.

    Science.gov (United States)

    Duggal, K L

    2016-01-01

    A new technique is used to study a family of time-dependent null horizons, called " Evolving Null Horizons " (ENHs), of generalized Robertson-Walker (GRW) space-time [Formula: see text] such that the metric [Formula: see text] satisfies a kinematic condition. This work is different from our early papers on the same issue where we used (1 + n )-splitting space-time but only some special subcases of GRW space-time have this formalism. Also, in contrast to previous work, we have proved that each member of ENHs is totally umbilical in [Formula: see text]. Finally, we show that there exists an ENH which is always a null horizon evolving into a black hole event horizon and suggest some open problems.

  20. "It feels good to be measured": clinical role-play, Walker Percy, and the tingles.

    Science.gov (United States)

    Ahuja, Nitin K

    2013-01-01

    A large online community has recently formed around autonomous sensory meridian response (ASMR), a pleasant and poorly understood somatic reaction to specific interpersonal triggers. Its web-based manifestations include a variety of amateur videos designed to elicit the reaction, many of which feature protracted imitations of a clinician's physical exam. This analysis considers through a literary lens the proximity of this phenomenon to clinical diagnostics, focusing in particular on characterizations of spiritual isolation elaborated in Love in the Ruins (1971), the third novel by physician-writer Walker Percy (1916-1990). Within this speculative framework, the tendency to derive pleasure from clinical milieus, real or constructed, may be interpreted as a quality particular to the postmodern psyche. Viewing web-based clinical role-play in light of Percy's writing also underscores the possibility that routine diagnostic assessments may have independent therapeutic implications.