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Sample records for blastn substitution matrix

  1. Optimization of the BLASTN substitution matrix for prediction of non-specific DNA microarray hybridization

    DEFF Research Database (Denmark)

    Eklund, Aron Charles; Friis, Pia; Wernersson, Rasmus;

    2010-01-01

    DNA microarray measurements are susceptible to error caused by non-specific hybridization between a probe and a target (cross-hybridization), or between two targets (bulk-hybridization). Search algorithms such as BLASTN can quickly identify potentially hybridizing sequences. We set out to improve...

  2. Empirical codon substitution matrix

    Directory of Open Access Journals (Sweden)

    Gonnet Gaston H

    2005-06-01

    Full Text Available Abstract Background Codon substitution probabilities are used in many types of molecular evolution studies such as determining Ka/Ks ratios, creating ancestral DNA sequences or aligning coding DNA. Until the recent dramatic increase in genomic data enabled construction of empirical matrices, researchers relied on parameterized models of codon evolution. Here we present the first empirical codon substitution matrix entirely built from alignments of coding sequences from vertebrate DNA and thus provide an alternative to parameterized models of codon evolution. Results A set of 17,502 alignments of orthologous sequences from five vertebrate genomes yielded 8.3 million aligned codons from which the number of substitutions between codons were counted. From this data, both a probability matrix and a matrix of similarity scores were computed. They are 64 × 64 matrices describing the substitutions between all codons. Substitutions from sense codons to stop codons are not considered, resulting in block diagonal matrices consisting of 61 × 61 entries for the sense codons and 3 × 3 entries for the stop codons. Conclusion The amount of genomic data currently available allowed for the construction of an empirical codon substitution matrix. However, more sequence data is still needed to construct matrices from different subsets of DNA, specific to kingdoms, evolutionary distance or different amount of synonymous change. Codon mutation matrices have advantages for alignments up to medium evolutionary distances and for usages that require DNA such as ancestral reconstruction of DNA sequences and the calculation of Ka/Ks ratios.

  3. Systematic Exploration of an Efficient Amino Acid Substitution Matrix: MIQS.

    Science.gov (United States)

    Tomii, Kentaro; Yamada, Kazunori

    2016-01-01

    Amino acid sequence comparisons to find similarities between proteins are fundamental sequence information analyses for inferring protein structure and function. In this study, we improve amino acid substitution matrices to identify distantly related proteins. We systematically sampled and benchmarked substitution matrices generated from the principal component analysis (PCA) subspace based on a set of typical existing matrices. Based on the benchmark results, we identified a region of highly sensitive matrices in the PCA subspace using kernel density estimation (KDE). Using the PCA subspace, we were able to deduce a novel sensitive matrix, called MIQS, which shows better detection performance for detecting distantly related proteins than those of existing matrices. This approach to derive an efficient amino acid substitution matrix might influence many fields of protein sequence analysis. MIQS is available at http://csas.cbrc.jp/Ssearch/ . PMID:27115635

  4. Aligning protein sequence and analysing substitution pattern using a class-specific matrix

    Indian Academy of Sciences (India)

    Hai Song Xu; Wen Ke Ren; Xiao Hui Liu; Xiao Qin Li

    2010-06-01

    Aligning protein sequences using a score matrix has became a routine but valuable method in modern biological research. However, alignment in the ‘twilight zone’ remains an open issue. It is feasible and necessary to construct a new score matrix as more protein structures are resolved. Three structural class-specific score matrices (all-alpha, all-beta and alpha/beta) were constructed based on the structure alignment of low identity proteins of the corresponding structural classes. The class-specific score matrices were significantly better than a structure-derived matrix (HSDM) and three other generalized matrices (BLOSUM30, BLOSUM60 and Gonnet250) in alignment performance tests. The optimized gap penalties presented here also promote alignment performance. The results indicate that different protein classes have distinct amino acid substitution patterns, and an amino acid score matrix should be constructed based on different structural classes. The class-specific score matrices could also be used in profile construction to improve homology detection.

  5. RMOS blastn result - KOME | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available KOME RMOS blastn result Data detail Data name RMOS blastn result Description of data contents Results of blastn searche...a acquisition method Rice genome sequences used for the searches were obtained from the Rice Microarray Open...ing Site (RMOS). Data analysis method Performed blastn (blast 2.2.12) searches ag

  6. A novel dermal matrix generated from burned skin as a promising substitute for deep-degree burns therapy

    OpenAIRE

    YU, GUANYING; Ye, Lan; Tan, Wei; ZHU, XUGUO; LI, YAONAN; JIANG, DUYIN

    2016-01-01

    The extensive skin defects induced by severe burns are dangerous and can be fatal. Currently, the most common therapy is tangential excision to remove the necrotic or denatured areas of skin, followed by skin grafting. Xenogeneic dermal substitutes, such as porcine acellular dermal matrix (ADM), are typically used to cover the burn wounds, and may accelerate wound healing. It is assumed that burned skin that still maintains partial biological activity may be recycled to construct an autologou...

  7. GenBank blastn search result - KOME | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available tents Results of blastn searches against GenBank nucleotide sequences Data file File name: kome_genbank_blas...view/kome_genbank_blastn_search_result#en Data acquisition method Performed blastn searches against Genbank ...nucleotide sequences. Data analysis method Performed homology searches against se...quences obtained from NCBI GenBank Release 150.0 (15/08/2005) using the blastn program (blast2.2.12). Sequences used in the searche

  8. A novel dermal matrix generated from burned skin as a promising substitute for deep-degree burns therapy.

    Science.gov (United States)

    Yu, Guanying; Ye, Lan; Tan, Wei; Zhu, Xuguo; Li, Yaonan; Jiang, Duyin

    2016-03-01

    The extensive skin defects induced by severe burns are dangerous and can be fatal. Currently, the most common therapy is tangential excision to remove the necrotic or denatured areas of skin, followed by skin grafting. Xenogeneic dermal substitutes, such as porcine acellular dermal matrix (ADM), are typically used to cover the burn wounds, and may accelerate wound healing. It is assumed that burned skin that still maintains partial biological activity may be recycled to construct an autologous acellular dermal matrix, termed 'deep‑degree burned dermal matrix (DDBDM)'. In theory, DDBDM may avoid the histoincompatibility issues associated with foreign or xenogeneic dermal matrices, and reduce therapy costs by making full use of discarded skin. In the present study, the collagens within prepared DDBDM were thickened, disorganized and partially fractured, however, they still maintained their reticular structure and tensile strength (P<0.01). Through microarray analysis of the cytokines present in ADM and DDBDM, it was determined that the DDBDM did not produce excessive levels of harmful burn toxins. Following 4 weeks of subcutaneous implantation, ADM and DDBDM were incompletely degraded and maintained good integrity. No significant inflammatory reaction or rejection were observed, which indicated that ADM and DDBDM have good histocompatibility. Therefore, DDBDM may be a useful material for the treatment of deep‑degree burns. PMID:26846279

  9. Use of a Collagen Matrix as a Substitute for Free Mucosal Grafts in Pre-Prosthetic Surgery: 1 Year Results From a Clinical Prospective Study on 15 Patients

    Science.gov (United States)

    Maiorana, Carlo; Beretta, Mario; Pivetti, Luca; Stoffella, Enrico; Grossi, Giovanni B.; Herford, Alan S.

    2016-01-01

    Background: The presence of keratinized tissue around dental implants is more than desirable either from a functional and aesthetic point of view, making soft tissue grafting a common practice in implant rehabilitation. Autogenous soft tissue grafting procedures are usually associated with high morbidity. Aim of this study was to assess the efficacy of a xenogeneic collagen matrix as a substitute for soft tissue grafting around dental implants. Methods: 15 consecutive patients underwent a vestibuloplasty and grafting, both in the mandible and the maxilla, with a collagen matrix. Results: The primary endpoint was to evaluate the resorption of the graft along with the re-epithelization grafted area. The percentage of the resorption was 44,4%, with a mean gain in vestibular height of 3 mm. Secondary endpoints evaluated the clinical appearance, the hemostatic effect and the post-operative pain. All subjects referred minimal pain with no bleeding. No adverse reaction nor infection were noted. Conclusion: This study showed that the used collagen matrix can find major interest in those patients who need a greater aesthetic outcome as the matrix has a perfect integration with the surrounding tissues. Furthermore it is strongly recommended for those patients who can bear little pain. Clinical Significance: Post-operative morbidity of autologous grafts is the biggest concern of this type of surgery. The possibility to use a soft tissue substitute is a great achievement as morbidity decreases and bigger areas can be treated in a single surgery. The present study showed the efficacy of a collagen matrix as this kind of substitute. PMID:27583050

  10. Physiologically Based Pharmacokinetic Modeling for Substitutability Analysis of Venlafaxine Hydrochloride Extended-Release Formulations Using Different Release Mechanisms: Osmotic Pump Versus Openable Matrix.

    Science.gov (United States)

    Lin, Ho-Pi; Sun, Dajun; Zhang, Xinyuan; Wen, Hong

    2016-10-01

    A Food and Drug Administration-approved generic oral product of venlafaxine hydrochloride (HCl) extended-release (ER) tablets has used a release mechanism based on an openable matrix, which is different from the push-pull osmotic pump system of its reference-listed drug. In an extreme case, a delay in the bursting of the openable matrix may be considered a product failure mode that alters the intended profile of systemic exposure. A physiologically based pharmacokinetic absorption model was established and verified to simulate the pharmacokinetic profiles after a single-dose oral administration of ER venlafaxine HCl tablets based on an osmotic pump or openable matrix design. This model adequately predicted the observed human mean pharmacokinetic metrics with drug-release profiles under most dissolution conditions. The results indicated that a bioinequivalence risk is minimal for a delayed onset of drug release from the approved generic venlafaxine HCl ER tablets with an openable matrix design, supporting its substitutability to the reference product. PMID:27449228

  11. Histological and histomorphometrical analysis of a silica matrix embedded nanocrystalline hydroxyapatite bone substitute using the subcutaneous implantation model in Wistar rats

    Energy Technology Data Exchange (ETDEWEB)

    Ghanaati, Shahram; Orth, Carina; Barbeck, Mike; Kirkpatrick, Charles James [Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz (Germany); Willershausen, Ines [Institute for Dental Material Sciences and Technology, University Medical Center of the Johannes Gutenberg University Mainz, Anselm-Franz-von-Bentzel-Weg 14, 55128 Mainz (Germany); Thimm, Benjamin W [Institute for Biomechanics, ETH Zuerich, Wolfgang-Pauli-Str.10, 8093 Zuerich (Switzerland); Booms, Patrick [Leeds Institute of Molecular Medicine, Section of Medicine, Surgery and Anaesthesia, University of Leeds (United Kingdom); Stuebinger, Stefan; Landes, Constantin; Sader, Robert Anton, E-mail: ghanaati@uni-mainz.d [Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Theodor-Stein-Kai 7, 60596 Frankfurt am Main (Germany)

    2010-06-01

    The clinical suitability of a bone substitute material is determined by the ability to induce a tissue reaction specific to its composition. The aim of this in vivo study was to analyze the tissue reaction to a silica matrix-embedded, nanocrystalline hydroxyapatite bone substitute. The subcutaneous implantation model in Wistar rats was chosen to assess the effect of silica degradation on the vascularization of the biomaterial and its biodegradation within a time period of 6 months. Already at day 10 after implantation, histomorphometrical analysis showed that the vascularization of the implantation bed reached its peak value compared to all other time points. Both vessel density and vascularization significantly decreased until day 90 after implantation. In this time period, the bone substitute underwent a significant degradation initiated by TRAP-positive and TRAP-negative multinucleated giant cells together with macrophages and lymphocytes. Although no specific tissue reaction could be related to the described silica degradation, the biomaterial was close to being fully degraded without a severe inflammatory response. These characteristics are advantageous for bone regeneration and remodeling processes.

  12. Own Experience From The Use Of A Substitute Of An Allogeneic Acellular Dermal Matrix Revitalized With In Vitro Cultured Skin Cells In Clinical Practice

    Directory of Open Access Journals (Sweden)

    Łabuś Wojciech

    2015-10-01

    Full Text Available As a result of the removal of cells from human allogeneic dermis, a collagen scaffold is obtained, which can be populated de novo with autologous/allogeneic skin cells and transplanted onto the area of skin loss. The optimal method for production of acellular dermal matrices (ADM has been selected. Three female patients (a mean age of 54 years were subjected to the transplantation of either autologous or allogeneic keratinocytes and fibroblasts into the holes of acellular dermal matrix (ADM mesh graft. The method for burn wound treatment based on the use of a viable dermal-epidermal skin substitute (based on ADM and in vitro cultured fibroblasts and keratinocytes may be the optimal method of burn treatment.

  13. Own Experience From The Use Of A Substitute Of An Allogeneic Acellular Dermal Matrix Revitalized With In Vitro Cultured Skin Cells In Clinical Practice.

    Science.gov (United States)

    Łabuś, Wojciech; Kawecki, Marek; Glik, Justyna; Maj, Mariusz; Kitala, Diana; Misiuga, Marcelina; Klama-Baryła, Agnieszka; Kraut, Małgorzata; Nowak, Mariusz

    2015-10-01

    As a result of the removal of cells from human allogeneic dermis, a collagen scaffold is obtained, which can be populated de novo with autologous/allogeneic skin cells and transplanted onto the area of skin loss. The optimal method for production of acellular dermal matrices (ADM) has been selected. Three female patients (a mean age of 54 years) were subjected to the transplantation of either autologous or allogeneic keratinocytes and fibroblasts into the holes of acellular dermal matrix (ADM) mesh graft. The method for burn wound treatment based on the use of a viable dermal-epidermal skin substitute (based on ADM and in vitro cultured fibroblasts and keratinocytes) may be the optimal method of burn treatment. PMID:26812752

  14. Instrumented fusion of thoracolumbar fracture with type I mineralized collagen matrix combined with autogenous bone marrow as a bone graft substitute: a four-case report

    OpenAIRE

    Faundez, Antonio; Taylor, Sofia; Kaelin, André

    2006-01-01

    In order to avoid the morbidity from autogenous bone harvesting, bone graft substitutes are being used more frequently in spinal surgery. There is indirect radiological evidence that bone graft substitutes are efficacious in humans. The purpose of this four-case study was to visually, manually, and histologically assess the quality of a fusion mass produced by a collagen hydroxyapatite scaffold impregnated with autologous bone marrow aspirate for posterolateral fusion. Four patients sustained...

  15. Are seismic velocity time-lapse changes due to fluid substitution or matrix dissolution? A CO2 sequestration study at Pohokura Field, New Zealand

    Science.gov (United States)

    Adam, L.; Sim, C. Y.; Macfarlane, J.; van Wijk, K.; Shragge, J. C.; Higgs, K.

    2015-12-01

    Time-lapse seismic signatures can be used to quantify fluid saturation and pressure changes in a reservoir undergoing CO2 sequestration. However, the injection of CO2 acidifies the water, which may dissolve and/or precipitate minerals. Understanding the impact on the rock frame from field seismic time-lapse changes remains an outstanding challenge. Here, we study the effects of carbonate-CO2-water reactions on the physical and elastic properties of rock samples with variable volumes of carbonate cementation. The effects of fluid substitution alone (brine to CO2) and those due to the combination of fluid substitution and mineral dissolution on time-lapse seismic signatures are studied by combining laboratory data, geophysical well-log data and 1-D seismic modeling. Nine rocks from Pohokura Field (New Zealand) are reacted with carbonic acid. The elastic properties are measured using a high-density laser-ultrasonic setup. We observe that P-wave velocity changes up to -19% and correlate with sandstone grain size. Coarse-grained sandstones show greater changes in elastic wave velocities due to dissolution than fine-grained sandstones. To put this in perspective, this velocity change is comparable to the effect of fluid substitution from brine to CO2. This can potentially create an ambiguity in the interpretation of the physical processes responsible for time-lapse signatures in a CO2injection scenario. The laboratory information is applied onto well-log data to model changes in elastic properties of sandstones at the well-log scale. Well-logs and core petrographic analyses are used to find an elastic model that best describes the observed elastic waves velocities in the cemented reservoir sandstones. The Constant-cement rock physics model is found to predict the elastic behaviour of the cemented sandstones. A possible late-time sequestration scenario is that both mineral dissolution and fluid substitution occur in the reservoir. 1-D synthetic seismograms show that

  16. Substitutional analysis

    CERN Document Server

    Rutherford, Daniel Edwin

    2013-01-01

    Classic monograph, suitable for advanced undergraduates and graduate students. Topics include calculus of permutations and tableaux, semi-normal representation, orthogonal and natural representations, group characters, and substitutional equations. 1968 edition.

  17. Solvent substitution

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The DOE Environmental Restoration and Waste Management Office of Technology Development and the Air Force Engineering and Services Center convened the First Annual International Workshop on Solvent Substitution on December 4--7, 1990. The primary objectives of this joint effort were to share information and ideas among attendees in order to enhance the development and implementation of required new technologies for the elimination of pollutants associated with industrial use of hazardous and toxic solvents; and to aid in accelerating collaborative efforts and technology transfer between government and industry for solvent substitution. There were workshop sessions focusing on Alternative Technologies, Alternative Solvents, Recovery/Recycling, Low VOC Materials and Treatment for Environmentally Safe Disposal. The 35 invited papers presented covered a wide range of solvent substitution activities including: hardware and weapons production and maintenance, paint stripping, coating applications, printed circuit boards, metal cleaning, metal finishing, manufacturing, compliance monitoring and process control monitoring. This publication includes the majority of these presentations. In addition, in order to further facilitate information exchange and technology transfer, the US Air Force and DOE solicited additional papers under a general Call for Papers.'' These papers, which underwent review and final selection by a peer review committee, are also included in this combined Proceedings/Compendium. For those involved in handling, using or managing hazardous and toxic solvents, this document should prove to be a valuable resource, providing the most up-to-date information on current technologies and practices in solvent substitution. Individual papers are abstracted separated.

  18. Solvent substitution

    International Nuclear Information System (INIS)

    The DOE Environmental Restoration and Waste Management Office of Technology Development and the Air Force Engineering and Services Center convened the First Annual International Workshop on Solvent Substitution on December 4--7, 1990. The primary objectives of this joint effort were to share information and ideas among attendees in order to enhance the development and implementation of required new technologies for the elimination of pollutants associated with industrial use of hazardous and toxic solvents; and to aid in accelerating collaborative efforts and technology transfer between government and industry for solvent substitution. There were workshop sessions focusing on Alternative Technologies, Alternative Solvents, Recovery/Recycling, Low VOC Materials and Treatment for Environmentally Safe Disposal. The 35 invited papers presented covered a wide range of solvent substitution activities including: hardware and weapons production and maintenance, paint stripping, coating applications, printed circuit boards, metal cleaning, metal finishing, manufacturing, compliance monitoring and process control monitoring. This publication includes the majority of these presentations. In addition, in order to further facilitate information exchange and technology transfer, the US Air Force and DOE solicited additional papers under a general ''Call for Papers.'' These papers, which underwent review and final selection by a peer review committee, are also included in this combined Proceedings/Compendium. For those involved in handling, using or managing hazardous and toxic solvents, this document should prove to be a valuable resource, providing the most up-to-date information on current technologies and practices in solvent substitution. Individual papers are abstracted separated

  19. Skin Substitutes

    OpenAIRE

    Zavan, Barbara; Vindigni, Vincenzo; Cortivo, Roberta; Abatangelo, Giovanni

    2010-01-01

    The many studies conducted so far reveal that Tissue Engineering of the skin is only at the beginning of its use in human applications. Burns patients were the first targets for such tissue substitutes, then chronic diseases, such as venous ulcers, have followed. The more experience is gained from the surgeon, the more feedback for the basic scientist to improve the product and to broaden clinical indications. Nowadays, progress in cell culture and biomedical material technologies have added ...

  20. Research on FIoating SeedIing Effects of SeveraI Substitute Matrix in FIue -cured Tobacco%几种烟草育苗替代基质育苗效果研究

    Institute of Scientific and Technical Information of China (English)

    谭思思; 黄银章; 姚强; 向鹏华; 张小良; 郭维; 龙世平

    2015-01-01

    easily find that,the seedling effects and agronomic traits of T3 was similar to CK based on comprehensive comparison for physical and chemical properties and seedling growth,and which can substitute commercial peat matrix for seedling in flue-cured tobacco production.

  1. Nonallograft osteoconductive bone graft substitutes.

    Science.gov (United States)

    Bucholz, Robert W

    2002-02-01

    An estimated 500,000 to 600,000 bone grafting procedures are done annually in the United States. Approximately (1/2) of these surgeries involve spinal arthrodesis whereas 35% to 40% are used for general orthopaedic applications. Synthetic bone graft substitutes currently represent only 10% of the bone graft market, but their share is increasing as experience and confidence in their use are accrued. Despite 15 to 20 years of clinical experience with various synthetic substitutes, there have been few welldesigned, controlled clinical trials of these implants. Synthetic bone graft substitutes consist of hydroxyapatite, tricalcium phosphate, calcium sulfate, or a combination of these minerals. Their fabrication technique, crystallinity, pore dimensions, mechanical properties, and resorption rate vary. All synthetic porous substitutes share numerous advantages over autografts and allografts including their unlimited supply, easy sterilization, and storage. However, the degree to which the substitute provides an osteoconductive structural framework or matrix for new bone ingrowth differs among implants. Disadvantages of ceramic implants include brittle handling properties, variable rates of resorption, poor performance in diaphyseal defects, and potentially adverse effects on normal bone remodeling. These inherent weaknesses have refocused their primary use to bone graft extenders and carriers for pharmaceuticals. The composition, histologic features, indications, and clinical experience of several of the synthetic bone graft substitutes approved for orthopaedic use in the United States are reviewed. PMID:11937865

  2. Time rate collision matrix

    International Nuclear Information System (INIS)

    The collision integral terms in Boltzmann equation are reformulated numerically leading to the substitution of the multiple integrals with a multiplicative matrix of the two colliding species velocity distribution functions which varies with the differential collision cross section. A matrix of lower rank may be constructed when one of the distribution functions is specified, in which case the matrix elements represent kinetic transition probabilities in the velocity space and the multiplication of the time rate collision matrix with the unknown velocity distribution function expresses the time rate of change of the distribution. The collision matrix may be used to describe the time evolution of systems in nonequilibrium conditions, to evaluate the rate of momentum and energy transfer between given species, or to generate validity criteria for linearized kinetic equations

  3. Biologic and synthetic skin substitutes: An overview

    Directory of Open Access Journals (Sweden)

    Halim Ahmad

    2010-10-01

    Full Text Available The current trend of burn wound care has shifted to more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various aetiologies. At present, there is no ideal substitute in the market. Skin substitutes can be divided into two main classes, namely, biological and synthetic substitutes. The biological skin substitutes have a more intact extracellular matrix structure, while the synthetic skin substitutes can be synthesised on demand and can be modulated for specific purposes. Each class has its advantages and disadvantages. The biological skin substitutes may allow the construction of a more natural new dermis and allow excellent re-epithelialisation characteristics due to the presence of a basement membrane. Synthetic skin substitutes demonstrate the advantages of increase control over scaffold composition. The ultimate goal is to achieve an ideal skin substitute that provides an effective and scar-free wound healing.

  4. Simple, heart-smart substitutions

    Science.gov (United States)

    Coronary artery disease - heart smart substitutions; Atherosclerosis - heart smart substitutions; Cholesterol - heart smart substitutions; Coronary heart disease - heart smart substitutions; Healthy diet - heart ...

  5. The impact of single substitutions on multiple sequence alignments.

    Science.gov (United States)

    Klaere, Steffen; Gesell, Tanja; von Haeseler, Arndt

    2008-12-27

    We introduce another view of sequence evolution. Contrary to other approaches, we model the substitution process in two steps. First we assume (arbitrary) scaled branch lengths on a given phylogenetic tree. Second we allocate a Poisson distributed number of substitutions on the branches. The probability to place a mutation on a branch is proportional to its relative branch length. More importantly, the action of a single mutation on an alignment column is described by a doubly stochastic matrix, the so-called one-step mutation matrix. This matrix leads to analytical formulae for the posterior probability distribution of the number of substitutions for an alignment column.

  6. Matrix-assisted laser desorption/ionization time-of-flight and nano-electrospray ionization ion trap mass spectrometric characterization of 1-cyano-2-substituted-benz[f]isoindole derivatives of peptides for fluorescence detection

    DEFF Research Database (Denmark)

    Linnemayr, K; Brückner, A; Körner, R;

    1999-01-01

    and emission wavelengths of 420 and 490 nm, respectively. After removal of unreacted compounds, the peptide conjugates were characterized by matrix-assisted laser desorption/ionization (MALDI) time-of-flight and nano-electrospray ionization (ESI) ion trap mass spectrometry. They readily form both [M + H]+ ions...

  7. Medicineringsfejl ved generisk substitution

    DEFF Research Database (Denmark)

    Rölfing, Jan

    2012-01-01

    Generic substitution is a major cause of medical mistakes in the general population. Danish legislation obligates pharmacies to substitute prescribed medicine with the cheapest equivalent formulation, despite variations in product name, packaging, shape and colour. Consequently, medical mistakes...

  8. Matrix isolation studies of the interactions of BF3 with water and substituted diethyl ethers. Chemical ionization mass spectrometric determination of the proton affinity of (CF3CH2)2O

    Science.gov (United States)

    Ball, David W.; Zehe, Michael J.

    1993-01-01

    BF3 was co-condensed with H2O, D2O, (C2H5)2O, (CF3CH2)2O, and (C2F5)2O in excess argon at 15 K. Infrared spectra of BF3/water isolated in solid argon provided a more complete analysis of the BF3--H2O complex than previously published. Infrared spectra of the matrices showed a definite Lewis acid-base interaction between BF3 and diethyl ether; a weak but definite interaction with bis (2,2,2-trifluorodiethyl) ether, and no observable interaction with perfluorodiethyl ether. Thus, the ether data indicate a clear trend between strength of interaction with BF3 and the degree of F substitution. To support and explain the emerging relationship between interaction strength and the basicity of the oxygen-containing molecule, the proton affinity of (CF3CH2)2O was measured using chemical ionization mass spectrometry. The implications of the results for lubricant/metal oxide surface interactions are discussed.

  9. Fractal dual substitution tilings

    OpenAIRE

    Frank, Natalie Priebe; Webster, Samuel B. G.; Whittaker, Michael F.

    2014-01-01

    Starting with a substitution tiling, we demonstrate a method for constructing infinitely many new substitution tilings. Each of these new tilings is derived from a graph iterated function system and the tiles have fractal boundary. We show that each of the new tilings is mutually locally derivable to the original tiling. Thus, at the tiling space level, the new substitution rules are expressing geometric and combinatorial, rather than topological, features of the original. Our method is easy ...

  10. Neutron scattering from a substitutional mass defect

    International Nuclear Information System (INIS)

    The dynamic structure factor is calculated for a low concentration of light mass scatterers substituted in a cubic crystal matrix. A new numerical method for the exact calculation is demonstrated. A local density of states for the low momentum transfer limit, and the shifts and widths of the oscillator peaks in the high momentum transfer limit are derived. The limitations of an approximation which decouples the defect from the lattice is discussed. (author)

  11. Matrix calculus

    CERN Document Server

    Bodewig, E

    1959-01-01

    Matrix Calculus, Second Revised and Enlarged Edition focuses on systematic calculation with the building blocks of a matrix and rows and columns, shunning the use of individual elements. The publication first offers information on vectors, matrices, further applications, measures of the magnitude of a matrix, and forms. The text then examines eigenvalues and exact solutions, including the characteristic equation, eigenrows, extremum properties of the eigenvalues, bounds for the eigenvalues, elementary divisors, and bounds for the determinant. The text ponders on approximate solutions, as well

  12. A unified approach to the transition matrices of DNA substitution models.

    Science.gov (United States)

    Yap, Von Bing

    2013-04-01

    For a reversible finite-state continuous-time Markov chain containing similar states, the computation of the transition matrix can be expressed quite elegantly in terms of the transition matrix of an associated lumped Markov chain. This result is immensely useful for obtaining explicit transition matrices for many DNA substitution models, without diagonalizing a matrix or solving a differential equation. Furthermore, the technique works for the analogous problem in the discrete-time DNA substitution models. PMID:23313463

  13. Electricity/oil substitution

    International Nuclear Information System (INIS)

    The extent to which electricity could substitute for imported oil in Canada is assessed and it is concluded that the bulk of projected oil imports could be displaced. This substitution of electricity for oil could be largely completed within two decades, with existing technology, using Canadian resources. The substitution of electricity for imported oil would result in relatively low energy costs and would stimulate economic growth. Energy self-sufficiency through the substitution of electricity for oil is uniquely a Canadian option; it is not open to other industrial countries. The option exists because of Canada's resources of oil sands for essential liquid fuels, hydraulic and nuclear electrical potential, and natural gas as an interim source of energy. While other countries face an energy crisis due to declining supplies of oil, Canada faces opportunities. The policies of Federal and Provincial governments, as perceived by individual decision makers, will have a major influence on Canada's ability to realize opportunities. (auth)

  14. Synthesis of substituted pyrazines

    Energy Technology Data Exchange (ETDEWEB)

    Pagoria, Philip F.; Zhang, Mao Xi

    2016-10-04

    A method for synthesizing a pyrazine-containing material according to one embodiment includes contacting an iminodiacetonitrile derivative with a base and a reagent selected from a group consisting of hydroxylamine, a hydroxylamine salt, an aliphatic primary amine, a secondary amine, an aryl-substituted alkylamine a heteroaryl-substituted alkyl amine, an alcohol, an alkanolamine and an aryl alcoholamine. Additional methods and several reaction products are presented. ##STR00001##

  15. Matrix Thermalization

    CERN Document Server

    Craps, Ben; Nguyen, Kévin

    2016-01-01

    Matrix quantum mechanics offers an attractive environment for discussing gravitational holography, in which both sides of the holographic duality are well-defined. Similarly to higher-dimensional implementations of holography, collapsing shell solutions in the gravitational bulk correspond in this setting to thermalization processes in the dual quantum mechanical theory. We construct an explicit, fully nonlinear supergravity solution describing a generic collapsing dilaton shell, specify the holographic renormalization prescriptions necessary for computing the relevant boundary observables, and apply them to evaluating thermalizing two-point correlation functions in the dual matrix theory.

  16. Prioritizing substitution of organic solvents in industrial cleaning processes

    DEFF Research Database (Denmark)

    Rasmussen, Pia Brunn; Jacobsen, Thomas

    1997-01-01

    A method for prioritizing the substitution of volatile organic compounds (VOC) used in industrial cleaning processes is developed. The result is a matrix, which, if all information can be obtained, gives a comprehensive description of the effects, exposure and emission of VOC, as well...... as the prospects for performing the substitution with a vegetable ester. It can be a tool for companies to decide which cleaning process has the highest demand for substitution, if there is a choice between several processes, but it may also be a tool to convince companies to use non-volatile, low-toxic cleaning...

  17. The substitutability of reinforcers.

    Science.gov (United States)

    Green, Leonard; Freed, Debra E

    1993-07-01

    Substitutability is a construct borrowed from microeconomics that describes a continuum of possible interactions among the reinforcers in a given situation. Highly substitutable reinforcers, which occupy one end of the continuum, are readily traded for each other due to their functional similarity. Complementary reinforcers, at the other end of the continuum, tend to be consumed jointly in fairly rigid proportion, and therefore cannot be traded for one another except to achieve that proportion. At the center of the continuum are reinforcers that are independent with respect to each other; consumption of one has no influence on consumption of another. Psychological research and analyses in terms of substitutability employ standard operant conditioning paradigms in which humans and nonhumans choose between alternative reinforcers. The range of reinforcer interactions found in these studies is more readily accommodated and predicted when behavior-analytic models of choice consider issues of substitutability. New insights are gained into such areas as eating and drinking, electrical brain stimulation, temporal separation of choice alternatives, behavior therapy, drug use, and addictions. Moreover, the generalized matching law (Baum, 1974) gains greater explanatory power and comprehensiveness when measures of substitutability are included. PMID:16812696

  18. [Delegation yes, substitution no!].

    Science.gov (United States)

    Schroeder, A

    2014-08-01

    The aging of society leads on the one hand to increasing case numbers and on the other hand to a reduction in the number of physicians available for patient treatment. The delegation and substitution of medical duties as a tried and tested method is increasingly being recommended in order to compensate for the lack of physicians. The Berufsverband der Deutschen Urologen (BDU, Professional Association of German Urologists) supports the guiding principle of the Bundesärztekammer (Federal Medical Council) of "delegation yes, substitution no" and rejects a substitution of medical duties by non-medical academic health personnel. Against the background of the demographic changes, the increasing need for treatment and the current deficiency of junior physicians, a more extensive inclusion of well-qualified and experienced non-medical personnel by the delegation of medically responsible duties (medical scope of practice) can be an appropriate measure to maintain a good medical service in practices, hospitals and nursing homes. PMID:25047595

  19. Matrix inequalities

    CERN Document Server

    Zhan, Xingzhi

    2002-01-01

    The main purpose of this monograph is to report on recent developments in the field of matrix inequalities, with emphasis on useful techniques and ingenious ideas. Among other results this book contains the affirmative solutions of eight conjectures. Many theorems unify or sharpen previous inequalities. The author's aim is to streamline the ideas in the literature. The book can be read by research workers, graduate students and advanced undergraduates.

  20. Saving Outweighs Substituting

    Institute of Scientific and Technical Information of China (English)

    Sophia

    2007-01-01

    @@ Energy crisis has become great challenge to the whole world.As the vehicle population keeps soaring in China,effectie countermeasures should be taken timely to deal with global energy crisis.There are two ways out:one is to substitute and one is to save.

  1. Matrix analysis

    CERN Document Server

    Bhatia, Rajendra

    1997-01-01

    A good part of matrix theory is functional analytic in spirit. This statement can be turned around. There are many problems in operator theory, where most of the complexities and subtleties are present in the finite-dimensional case. My purpose in writing this book is to present a systematic treatment of methods that are useful in the study of such problems. This book is intended for use as a text for upper division and gradu­ ate courses. Courses based on parts of the material have been given by me at the Indian Statistical Institute and at the University of Toronto (in collaboration with Chandler Davis). The book should also be useful as a reference for research workers in linear algebra, operator theory, mathe­ matical physics and numerical analysis. A possible subtitle of this book could be Matrix Inequalities. A reader who works through the book should expect to become proficient in the art of deriving such inequalities. Other authors have compared this art to that of cutting diamonds. One first has to...

  2. Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options

    Directory of Open Access Journals (Sweden)

    Heidi Debels, MD

    2015-01-01

    Conclusions: Skin substitutes are a useful tool in plastic and reconstructive surgery practices as an alternative to skin grafts. In the choice of substitute, the general plastic surgery principle of replacing like tissue with like tissue seems to be still standing, and products most resembling the natural dermal extracellular matrix should be preferred.

  3. Esophageal substitutions in children.

    Directory of Open Access Journals (Sweden)

    Pedro A. Vilorio Barreras

    2005-12-01

    Full Text Available Esophageal replacements in children usually are necessary in patients with of esophageal atresia or those develop inflammatory scars after consumption of caustic substances. For the substitutive procedure diverse organs are employed, like small or thick intestine and stomach. We presented the Good Clinical Practices Guideline for Esophageal replacement, approved by consensus in the the 3th National Good Clinical Practices Workshop in Pediatric Surgery (Camagüey, Cuba; February 23 - 26, 2004.

  4. Selfdual Substitutions in Dimension One

    CERN Document Server

    Berthé, Valérie; Sirvent, Victor

    2011-01-01

    There are several notions of the 'dual' of a word/tile substitution. We show that the most common ones are equivalent for substitutions in dimension one, where we restrict ourselves to the case of two letters/tiles. Furthermore, we obtain necessary and sufficient arithmetic conditions for substitutions being selfdual in this case.

  5. Matrix pentagons

    CERN Document Server

    Belitsky, A V

    2016-01-01

    The Operator Product Expansion for null polygonal Wilson loop in planar maximally supersymmetric Yang-Mills theory runs systematically in terms of multiparticle pentagon transitions which encode the physics of excitations propagating on the color flux tube ending on the sides of the four-dimensional contour. Their dynamics was unravelled in the past several years and culminated in a complete description of pentagons as an exact function of the 't Hooft coupling. In this paper we provide a solution for the last building block in this program, the SU(4) matrix structure arising from internal symmetry indices of scalars and fermions. This is achieved by a recursive solution of the Mirror and Watson equations obeyed by the so-called singlet pentagons and fixing the form of the twisted component in their tensor decomposition. The non-singlet, or charged, pentagons are deduced from these by a limiting procedure.

  6. Random matrix theory and robust covariance matrix estimation for financial data

    CERN Document Server

    Frahm, G; Frahm, Gabriel; Jaekel, Uwe

    2005-01-01

    The traditional class of elliptical distributions is extended to allow for asymmetries. A completely robust dispersion matrix estimator (the `spectral estimator') for the new class of `generalized elliptical distributions' is presented. It is shown that the spectral estimator corresponds to an M-estimator proposed by Tyler (1983) in the context of elliptical distributions. Both the generalization of elliptical distributions and the development of a robust dispersion matrix estimator are motivated by the stylized facts of empirical finance. Random matrix theory is used for analyzing the linear dependence structure of high-dimensional data. It is shown that the Marcenko-Pastur law fails if the sample covariance matrix is considered as a random matrix in the context of elliptically distributed and heavy tailed data. But substituting the sample covariance matrix by the spectral estimator resolves the problem and the Marcenko-Pastur law remains valid.

  7. 40 CFR 721.10126 - Alkyl amino substituted triazine amino substituted benezenesulfonic acid reaction product with...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alkyl amino substituted triazine amino... substituted triazine amino substituted benezenesulfonic acid reaction product with naphthalenesulfonato azo... substituted triazine amino substituted benezenesulfonic acid reaction product with naphthalenesulfonato...

  8. THE STRUCTURE OF INVERTIBLE SUBSTITUTIONS ON A THREE-LETTER ALPHABET

    Institute of Scientific and Technical Information of China (English)

    Tan Bo; Wen Zhixiong; Zhang Yiping

    2003-01-01

    We study the structure of invertible substitutions on three-letter alphabet.We show that there exists a fi-nite set S of invertible substitutions such that any invertible substitution can be written as Iw o σ1 o σ2…σk,where Iw is the inner automorphism associated with w,and σj∈S for l≤j≤k.As a consequence,M is the matrix of an invertible substitution if and only if it is a finite product of non-negative elementary matrices.

  9. How Substitutable Is Natural Capital?

    OpenAIRE

    Markandya, Anil; Pedroso, S.

    2006-01-01

    One of the recurring themes in the sustainability literature has been the legitimacy of using an economic framework to account for natural resources. This paper examines the potential for substituting between different inputs in the generation of income, where the inputs include natural resources such as land and energy resources. A nested constant elasticity of substitution (CES) production function is used to allow flexibility in the estimated elasticities of substitution. Also, with this s...

  10. Substitute Valuations: Generation and Structure

    CERN Document Server

    Hajek, Bruce

    2007-01-01

    Substitute valuations (in some contexts called gross substitute valuations) are prominent in combinatorial auction theory. An algorithm is given in this paper for generating a substitute valuation through Monte Carlo simulation. In addition, the geometry of the set of all substitute valuations for a fixed number of goods K is investigated. The set consists of a union of polyhedrons, and the maximal polyhedrons are identified for K=4. It is shown that the maximum dimension of the maximal polyhedrons increases with K nearly as fast as two to the power K.

  11. Displacement, Substitution, Sublimation: A Bibliography.

    Science.gov (United States)

    Pedrini, D. T.; Pedrini, Bonnie C.

    Sigmund Freund worked with the mechanisms of displacement, substitution, and sublimation. These mechanisms have many similarities and have been studied diagnostically and therapeutically. Displacement and substitution seem to fit in well with phobias, hysterias, somatiyations, prejudices, and scapegoating. Phobias, prejudices, and scapegoating…

  12. Detailed assessment of homology detection using different substitution matrices

    Institute of Scientific and Technical Information of China (English)

    LI Jing; WANG Wei

    2006-01-01

    Homology detection plays a key role in bioinformatics, whereas substitution matrix is one of the most important components in homology detection. Thus, besides the improvement of alignment algorithms, another effective way to enhance the accuracy of homology detection is to use proper substitution matrices or even construct new matrices.A study on the features of various matrices and on the comparison of the performances between different matrices in homology detection enable us to choose the most proper or optimal matrix for some specific applications. In this paper, by taking BLOSUM matrices as an example, some detailed features of matrices in homology detection are studied by calculating the distributions of numbers of recognized proteins over different sequence identities and sequence lengths. Our results clearly showed that different matrices have different preferences and abilities to the recognition of remote homologous proteins. Furthermore, detailed features of the various matrices can be used to improve the accuracy of homology detection.

  13. Fibrous growth of strontium substituted hydroxyapatite and its drug release

    International Nuclear Information System (INIS)

    The effect of strontium on the crystallization of helical ribbon of hydroxyapatite (HAp) was investigated by single diffusion technique in silica gel matrix at 27 deg. C and physiological pH. Fibers of HAp were obtained on addition of strontium. The length of the HAp fibers, were found to decrease as the strontium substitution increases. The presence of strontium ion increased the crystallinity as well as crystallite size of HAp. The strontium substituted HAp (Sr-HAp) has similar stoichiometry to that of biological apatite. Sr-HAp was found to have increased surface area (35%) compared to control. Further, strontium substitution leads to an enhancement of in vitro bioactivity. The cumulative in-vitro amoxicillin drug release in phosphate buffer solution (PBS, pH 7.2) showed a prolonged release profile for Sr-HAp.

  14. Vitreous substitutes: challenges and directions

    Institute of Scientific and Technical Information of China (English)

    Qian-Ying; Gao; Yue; Fu; Yan-Nian; Hui

    2015-01-01

    The natural vitreous body has a fine structure and complex functions. The imitation of the natural vitreous body by vitreous substitutes is a challenging work for both researchers and ophthalmologists. Gases, silicone oil, heavy silicone oil and hydrogels, particularly the former two vitreous substitutes are clinically widely used with certain complications. Those, however, are not real artificial vitreous due to lack of structure and function like the natural vitreous body. This article reviews the situations, challenges, and future directions in the development of vitreous substitutes, particularly the experimental and clinical use of a new artificial foldable capsular vitreous body.

  15. Factor substitution in nursing homes.

    Science.gov (United States)

    Cawley, John; Grabowski, David C; Hirth, Richard A

    2006-03-01

    This paper studies factor substitution in one important sector: the nursing home industry. Specifically, we measure the extent to which nursing homes substitute materials for labor when labor becomes relatively more expensive. From a policy perspective, factor substitution in this market is important because materials-intensive methods of care are associated with greater risks of morbidity and mortality among nursing home residents. Studying longitudinal data from 1991 to 2000 on nearly every nursing home in the United States, we use the method of instrumental variables (IV) to address measurement error in nursing home wages. The results from the IV models yield evidence of factor substitution: higher nursing home wages are associated with greater use of psychoactive drugs and lower quality.

  16. Glass matrix composite material prepared with waste foundry sand

    Directory of Open Access Journals (Sweden)

    ZHANG Zhao-shu

    2006-11-01

    Full Text Available The technology of glass matrix of the composite material manufactured through a sintering process and using waste foundry sand and waste glass as the main raw materials was studied. The effects of technological factors on the performance of this material were studied. The results showed that this composite material is formed with glass as matrix, core particulate as strengthening material, it has the performance of glass and ceramics, and could be used to substitute for stone.

  17. Glass matrix composite material prepared with waste foundry sand

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhao-shu; XIA Ju-pei; ZHU Xiao-qin; LIU Fan; HE Mao-yun

    2006-01-01

    The technology of glass matrix of the composite material manufactured through a sintering process and using waste foundry sand and waste glass as the main raw materials was studied. The effects of technological factors on the performance of this material were studied. The results showed that this composite material is formed with glass as matrix, core particulate as strengthening material, it has the performance of glass and ceramics, and could be used to substitute for stone.

  18. Electrophilic Substitution Reactions of Indoles

    Science.gov (United States)

    Sundberg, Richard J.

    The topic of this chapter is electrophilic substitution of indole and its derivatives. The indole ring is highly reactive at its 3-position toward protonation, halogenation, alkylation and acylation. Electrophilic substitution can be combined with inter- or intramolecular addition at C-2. Intramolecular alkylation by iminium ions (Pictet-Spengler reaction) is particularly useful. Enantioselectivity can be achieved in many conjugate addition reactions. These reactions have been applied to synthesis of both natural products and drugs.

  19. Amalgam substitutes: a critical analysis

    OpenAIRE

    Lutz, Felix; Krejci, Ivo

    2000-01-01

    Quality standards for restorations recently have been defined in Switzerland. Amalgam substitutes must meet restoration Grade 2 requirements (i.e., pulp and dental hard substance must be preserved, and both form and function of the tooth have to be reconstituted). The pertinent operative technique has to be simple and amalgam-like. A minimum service life of 8 years is required. This in vitro study investigated the clinical potential of several amalgam substitutes, taking into account the oper...

  20. Ubiquitination of specific mitochondrial matrix proteins.

    Science.gov (United States)

    Lehmann, Gilad; Ziv, Tamar; Braten, Ori; Admon, Arie; Udasin, Ronald G; Ciechanover, Aaron

    2016-06-17

    Several protein quality control systems in bacteria and/or mitochondrial matrix from lower eukaryotes are absent in higher eukaryotes. These are transfer-messenger RNA (tmRNA), The N-end rule ATP-dependent protease ClpAP, and two more ATP-dependent proteases, HslUV and ClpXP (in yeast). The lost proteases resemble the 26S proteasome and the role of tmRNA and the N-end rule in eukaryotic cytosol is performed by the ubiquitin proteasome system (UPS). Therefore, we hypothesized that the UPS might have substituted these systems - at least partially - in the mitochondrial matrix of higher eukaryotes. Using three independent experimental approaches, we demonstrated the presence of ubiquitinated proteins in the matrix of isolated yeast mitochondria. First, we show that isolated mitochondria contain ubiquitin (Ub) conjugates, which remained intact after trypsin digestion. Second, we demonstrate that the mitochondrial soluble fraction contains Ub-conjugates, several of which were identified by mass spectrometry and are localized to the matrix. Third, using immunoaffinity enrichment by specific antibodies recognizing digested ubiquitinated peptides, we identified a group of Ub-modified matrix proteins. The modification was further substantiated by separation on SDS-PAGE and immunoblots. Last, we attempted to identify the ubiquitin ligase(s) involved, and identified Dma1p as a trypsin-resistant protein in our mitochondrial preparations. Taken together, these data suggest a yet undefined role for the UPS in regulation of the mitochondrial matrix proteins. PMID:27157140

  1. Ubiquitination of specific mitochondrial matrix proteins.

    Science.gov (United States)

    Lehmann, Gilad; Ziv, Tamar; Braten, Ori; Admon, Arie; Udasin, Ronald G; Ciechanover, Aaron

    2016-06-17

    Several protein quality control systems in bacteria and/or mitochondrial matrix from lower eukaryotes are absent in higher eukaryotes. These are transfer-messenger RNA (tmRNA), The N-end rule ATP-dependent protease ClpAP, and two more ATP-dependent proteases, HslUV and ClpXP (in yeast). The lost proteases resemble the 26S proteasome and the role of tmRNA and the N-end rule in eukaryotic cytosol is performed by the ubiquitin proteasome system (UPS). Therefore, we hypothesized that the UPS might have substituted these systems - at least partially - in the mitochondrial matrix of higher eukaryotes. Using three independent experimental approaches, we demonstrated the presence of ubiquitinated proteins in the matrix of isolated yeast mitochondria. First, we show that isolated mitochondria contain ubiquitin (Ub) conjugates, which remained intact after trypsin digestion. Second, we demonstrate that the mitochondrial soluble fraction contains Ub-conjugates, several of which were identified by mass spectrometry and are localized to the matrix. Third, using immunoaffinity enrichment by specific antibodies recognizing digested ubiquitinated peptides, we identified a group of Ub-modified matrix proteins. The modification was further substantiated by separation on SDS-PAGE and immunoblots. Last, we attempted to identify the ubiquitin ligase(s) involved, and identified Dma1p as a trypsin-resistant protein in our mitochondrial preparations. Taken together, these data suggest a yet undefined role for the UPS in regulation of the mitochondrial matrix proteins.

  2. Dicty_cDB: Contig-U14418-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ttnggangttaattaaagatnttntaaaaanaaaatnccgttnngg 304 Query: 305 aangtngataanaaagaagangaataga 332 |||||||||||||...||||||||||||||| Sbjct: 305 aangtngataanaaagaagangaataga 332 Lambda K H 1.37 0.711 1.31 Matrix: blastn matrix

  3. The Matrix Cookbook

    DEFF Research Database (Denmark)

    Petersen, Kaare Brandt; Pedersen, Michael Syskind

    Matrix identities, relations and approximations. A desktop reference for quick overview of mathematics of matrices.......Matrix identities, relations and approximations. A desktop reference for quick overview of mathematics of matrices....

  4. Matrix Order Differintegration

    OpenAIRE

    Naber, Mark

    2003-01-01

    The Riemann-Liouville formula for fractional derivatives and integrals (differintegration) is used to derive formulae for matrix order derivatives and integrals. That is, the parameter for integration and differentiation is allowed to assume matrix values. It is found that the computation of derivatives and integrals to matrix order is well defined for any square matrix over the complex numbers. Some properties are worked out for special classes of matrices. It is hoped that this new formalis...

  5. Matrix Tile Analysis

    OpenAIRE

    Givoni, Inmar; Cheung, Vincent; Frey, Brendan J.

    2012-01-01

    Many tasks require finding groups of elements in a matrix of numbers, symbols or class likelihoods. One approach is to use efficient bi- or tri-linear factorization techniques including PCA, ICA, sparse matrix factorization and plaid analysis. These techniques are not appropriate when addition and multiplication of matrix elements are not sensibly defined. More directly, methods like bi-clustering can be used to classify matrix elements, but these methods make the overly-restrictive assumptio...

  6. Matrix with Prescribed Eigenvectors

    Science.gov (United States)

    Ahmad, Faiz

    2011-01-01

    It is a routine matter for undergraduates to find eigenvalues and eigenvectors of a given matrix. But the converse problem of finding a matrix with prescribed eigenvalues and eigenvectors is rarely discussed in elementary texts on linear algebra. This problem is related to the "spectral" decomposition of a matrix and has important technical…

  7. Decellularized and Engineered Tendons as Biological Substitutes: A Critical Review

    Directory of Open Access Journals (Sweden)

    Arianna B. Lovati

    2016-01-01

    Full Text Available Tendon ruptures are a great burden in clinics. Finding a proper graft material as a substitute for tendon repair is one of the main challenges in orthopaedics, for which the requirement of a biological scaffold would be different for each clinical application. Among biological scaffolds, the use of decellularized tendon-derived matrix increasingly represents an interesting approach to treat tendon ruptures. We analyzed in vitro and in vivo studies focused on the development of efficient protocols for the decellularization and for the cell reseeding of the tendon matrix to obtain medical devices for tendon substitution. Our review considered also the proper tendon source and preclinical animal models with the aim of entering into clinical trials. The results highlight a wide panorama in terms of allogenic or xenogeneic tendon sources, specimen dimensions, physical or chemical decellularization techniques, and the cell type variety for reseeding from terminally differentiated to undifferentiated mesenchymal stem cells and their static or dynamic culture employed to generate implantable constructs tested in different animal models. We try to identify the most efficient approach to achieve an optimal biological scaffold for biomechanics and intrinsic properties, resembling the native tendon and being applicable in clinics in the near future, with particular attention to the Achilles tendon substitution.

  8. Decellularized and Engineered Tendons as Biological Substitutes: A Critical Review

    Science.gov (United States)

    Lovati, Arianna B.; Bottagisio, Marta; Moretti, Matteo

    2016-01-01

    Tendon ruptures are a great burden in clinics. Finding a proper graft material as a substitute for tendon repair is one of the main challenges in orthopaedics, for which the requirement of a biological scaffold would be different for each clinical application. Among biological scaffolds, the use of decellularized tendon-derived matrix increasingly represents an interesting approach to treat tendon ruptures. We analyzed in vitro and in vivo studies focused on the development of efficient protocols for the decellularization and for the cell reseeding of the tendon matrix to obtain medical devices for tendon substitution. Our review considered also the proper tendon source and preclinical animal models with the aim of entering into clinical trials. The results highlight a wide panorama in terms of allogenic or xenogeneic tendon sources, specimen dimensions, physical or chemical decellularization techniques, and the cell type variety for reseeding from terminally differentiated to undifferentiated mesenchymal stem cells and their static or dynamic culture employed to generate implantable constructs tested in different animal models. We try to identify the most efficient approach to achieve an optimal biological scaffold for biomechanics and intrinsic properties, resembling the native tendon and being applicable in clinics in the near future, with particular attention to the Achilles tendon substitution. PMID:26880985

  9. On Regular Power-Substitution

    Institute of Scientific and Technical Information of China (English)

    Huanyin CHEN

    2009-01-01

    The necessary and sufficient conditions under which a ring satisfies regular power-substitution are investigated. It is shown that a ring R satisfies regular power-substitution if and only if a(-~)b in R implies that there exist n ∈ N and a U ∈ GLn(R) such that aU =Ub if and only if for any regular x ∈ R there exist m,n ∈ N and U ∈ GLn(R) such that xmIn = xmUxm, where a(-~)b means that there exists x, y, z ∈ R such that a = ybx, b = xaz and x = xyx = xzx. It is proved that every directly finite simple ring satisfies regular power-substitution. Some applications for stably free R-modules are also obtained.

  10. Substitution systems and nonextensive statistics

    Science.gov (United States)

    García-Morales, V.

    2015-12-01

    Substitution systems evolve in time by generating sequences of symbols from a finite alphabet: At a certain iteration step, the existing symbols are systematically replaced by blocks of Nk symbols also within the alphabet (with Nk, a natural number, being the length of the kth block of the substitution). The dynamics of these systems leads naturally to fractals and self-similarity. By using B-calculus (García-Morales, 2012) universal maps for deterministic substitution systems both of constant and non-constant length, are formulated in 1D. It is then shown how these systems can be put in direct correspondence with Tsallis entropy. A 'Second Law of Thermodynamics' is also proved for these systems in the asymptotic limit of large words.

  11. THE PROBLEM OF SENSES SUBSTITUTION

    Directory of Open Access Journals (Sweden)

    Oreshkina M. A.

    2015-10-01

    Full Text Available The author deals with problems of substitution of senses and notions in the science and in the social life. Such processes result not only in distortion of the scientific worldview but also in absolutely undesirable social cataclysms. However, this scientific problem has not been yet worked out to sufficient extent, which hampers preventing the mentioned distortions of the real worldview and brings to unwanted consequences requiring correlation and corrections. The question of senses and notions substitution is not new in the science but it has not been yet sufficiently studied. We know that strictness of thinking must be dearly paid for in loss of flexibility in revaluation of senses, which makes you easily slip into dogmatism. It should be noted that this keeps taking place both in the science itself and in the life of society any science is called to serve. So the science can be hardly imagined without schools of thought. They ensure preservation of certain knowledge, vision, approach and, finally, of a certain school – they are traditions and authority of the science. However, having passed their golden age, when the founder used to be followed after several generations by dogmatists whose genius and talent were far from being so great, a school begins to degrade producing scholasticism by substitution and emasculation of senses and notions and finally destructs itself. The collectivization in the USSR in the 30ies of the 20th century and so-called “extremes” associated with it being that very substitution of sense platforms in its pure form constitutes a rather illustrative example of social manipulation based on the substitution of sense platforms. These activities relating to detection of senses and notions substitution will also be developed in the future. The truth will be approached as before through cleaning the knowledge of the myth, through searching for the original sense or the archetype separated from lie and fabrication

  12. Bosonic Matrix Theory and Matrix Dbranes

    CERN Document Server

    Chaudhuri, S

    2002-01-01

    We develop new tools for an in-depth investigation of our recent proposal for Matrix Theory. We construct the anomaly-free and finite planar continuum limit of the ground state with SO(2^{13}) symmetry matching with the tadpole and tachyon free IR stable high temperature ground state of the open and closed bosonic string. The correspondence between large N limits and spacetime effective actions is demonstrated more generally for an arbitrary D25brane ground state which might include brane-antibrane pairs or NS-branes and which need not have an action formulation. Closure of the finite N matrix Lorentz algebra nevertheless requires that such a ground state is simultaneously charged under all even rank antisymmetric matrix potentials. Additional invariance under the gauge symmetry mediated by the one-form matrix potential requires a ground state charged under the full spectrum of antisymmetric (p+1)-form matrix potentials with p taking any integer value less than 26. Matrix Dbrane democracy has a beautiful larg...

  13. Tax rates as strategic substitutes

    NARCIS (Netherlands)

    H. Vrijburg (Hendrik); R.A. de Mooij (Ruud)

    2016-01-01

    textabstractThis paper analytically derives conditions under which the slope of the tax-reaction function is negative in a classical tax competition model. If countries maximize welfare, a negative slope (reflecting strategic substitutability) occurs under relatively mild conditions. The strategic t

  14. No Substitute Teacher Left behind

    Science.gov (United States)

    O'Connor, Kevin

    2009-01-01

    Schools and districts routinely recruit, retain, and support highly qualified teachers to ensure that students receive the best learning opportunities. However, even if one's school employs highly qualified full-time teachers, it is important to acknowledge that substitute teachers also have a significant impact on the education of students. One…

  15. Parallelism in matrix computations

    CERN Document Server

    Gallopoulos, Efstratios; Sameh, Ahmed H

    2016-01-01

    This book is primarily intended as a research monograph that could also be used in graduate courses for the design of parallel algorithms in matrix computations. It assumes general but not extensive knowledge of numerical linear algebra, parallel architectures, and parallel programming paradigms. The book consists of four parts: (I) Basics; (II) Dense and Special Matrix Computations; (III) Sparse Matrix Computations; and (IV) Matrix functions and characteristics. Part I deals with parallel programming paradigms and fundamental kernels, including reordering schemes for sparse matrices. Part II is devoted to dense matrix computations such as parallel algorithms for solving linear systems, linear least squares, the symmetric algebraic eigenvalue problem, and the singular-value decomposition. It also deals with the development of parallel algorithms for special linear systems such as banded ,Vandermonde ,Toeplitz ,and block Toeplitz systems. Part III addresses sparse matrix computations: (a) the development of pa...

  16. Effect of the substitution of f-electron elements on the structure and elastic properties of UO2

    Science.gov (United States)

    Behera, Rakesh K.; Deo, Chaitanya S.; Xu, Haixuan

    2013-02-01

    The chemistry of nuclear reactor fuel initially is complex, and continuous loss of uranium and plutonium, and formation of a broad range of new species due to fission introduce a challenging time-dependence to this chemistry. Lanthanides and/or Actinides substitution on the uranium sublattice occurs (a) during fission, (b) when mixed oxide fuel is used, and (c) when minor Actinides are reprocessed in UO2 matrix fuel as part of a closed nuclear fuel cycle. These fission products and minor Actinides influence a variety of thermo-physical properties, which depend on structure and elastic properties. How these structural and elastic properties vary with Lanthanide and Actinide substitution is not well studied. In this study we use atomic level simulations to investigate the effect of 4+ and 3+ ion substitutions on the structural and elastic properties of urania matrix. Our results show that most of the 4+ ions reduce the overall lattice parameter, while all the 3+ ions considered here increased the lattice parameter of the urania matrix. This effect is guided by the interplay between the elastic and electrostatic effect of the substituted ions. We calculate the chemical expansion and chemical expansion coefficient with the change in concentration based on the ionic radii of the substituted 3+ and 4+ ions. In general, elastic properties are enhanced for 4+ ions substitution and reduced for 3+ ion substitution.

  17. Melvin Matrix Models

    CERN Document Server

    Motl, L

    2001-01-01

    In this short note we construct the DLCQ description of the flux seven-branes in type IIA string theory and discuss its basic properties. The matrix model involves dipole fields. We explain the relation of this nonlocal matrix model to various orbifolds. We also give a spacetime interpretation of the Seiberg-Witten-like map, proposed in a different context first by Bergman and Ganor, that converts this matrix model to a local, highly nonlinear theory.

  18. Mixed matrix membrane development.

    Science.gov (United States)

    Kulprathipanja, Santi

    2003-03-01

    Two types of mixed matrix membranes were developed by UOP in the late 1980s. The first type includes adsorbent polymers, such as silicalite-cellulose acetate (CA), NaX-CA, and AgX-CA mixed matrix membranes. The silicalite-CA has a CO(2)/H(2) selectivity of 5.15 +/- 2.2. In contrast, the CA membrane has a CO(2)/H(2) selectivity of 0.77 +/- 0.06. The second type of mixed matrix membrane is PEG-silicone rubber. The PEG-silicone rubber mixed matrix membrane has high selectivity for polar gases, such as SO(2), NH(3), and H(2)S.

  19. Modular Matrix Models

    OpenAIRE

    He, Y.; Jejjala, V.

    2003-01-01

    Inspired by a formal resemblance of certain q-expansions of modular forms and the master field formalism of matrix models in terms of Cuntz operators, we construct a Hermitian one-matrix model, which we dub the ``modular matrix model.'' Together with an N=1 gauge theory and a special Calabi-Yau geometry, we find a modular matrix model that naturally encodes the Klein elliptic j-invariant, and hence, by Moonshine, the irreducible representations of the Fischer-Griess Monster group.

  20. Amino acid substitution or insertion patterns in penicillin-binding protein 2 in Neisseria gonorrhoeae isolates with reduced susceptibility to ceftriaxone%头孢曲松低敏的淋球菌中青霉素结合蛋白2氨基酸替代或插入模式研究

    Institute of Scientific and Technical Information of China (English)

    蒋法兴; 其木格; 钱革; 郑波; 叶顺章; 苏晓红; 胡白; 王千秋

    2008-01-01

    Objective To investigate the amino acid patterns in penicillin-binding protein 2(PBP2)in Neisseria gonorrhoeae isolates with reduced susceptibility to ceftriaxonc.and the relationship between the amino acid patterns and reduced ceftriaxone susceptibility.Methods DNA was extracted from 13 clinical isolates of N.gonorrhoeae.including 11 strains with decreased susceptibility to ceftriaxone and 2 sensitive isolates.The full-length penA gene encoding the penicillin-binding protein 2 was amplified and sequenced.BLASTn and BLASTx programs were used to assess the insertion and substitution patterns of nucleotides in penA gene and of amino acids in PBP2,respectively.Results BLASTn analysis revealed insertion or substitution of 18-38 nucleotides in the penA gene of gonococcal isolates with reduced ceftriaxone susceptibility.As shown by BLASTX analysis.there were five patterns of amino acid substitution or insertion in PBP2 of the 11 isolates with reduced ceftriaxone susceptibility.However.mosaic structure of PBP2 was not found in any of these isolates.Conclusion Mosaic PBP2 seems not to be the major factor contributing to the decrease in susceptibility of N.gonorrhoeae to ceftriaxone.%目的 检测头孢曲松低敏的淋球菌中青霉素结合蛋白2(PBP2)模式,探讨其是否与淋球菌对头孢曲松敏感性降低有关.方法 将11株头孢曲松低敏和2株头孢曲松敏感的淋球菌penA基因全基因测序,通过BLASTn与BLASTx分析,研究penA基因的碱基插入和置换情况及PBP2中氨基酸插入和置换模式.结果 13株淋球菌的penA基因中有多个碱基置换或插入,PBP2中共发现5种模式的氨基酸插入或置换模式,没有发现PBP2镶嵌状结构模式.结论 PBP2的镶嵌状结构可能不是导致淋球菌对头孢曲松敏感性下降的主要因素.

  1. Substitute Students Do a Roaring Trade

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    UniverSity students employ substitutes for a wide range of duties, from attending compulsory morning exercises and classes to writing papers or even love letters, These substitutes advertise their services on campus bulletin boards,

  2. Commercial formalin substitutes for histopathology

    DEFF Research Database (Denmark)

    Prentø, P; Lyon, H

    1997-01-01

    of protein and structural immobilization, quality of histology and cellular structure following routine dehydration and paraffin embedding, and performance as a fixative for immunohistochemistry. Furthermore, we evaluated the effects of the various fixatives on ultrastructure. Only buffered formalin......We compared the performance of six commercial fixatives proposed to be formalin substitutes with the performance of buffered formalin, Clarke's ethanol-acetic acid, and ethanol, using rat liver, small intestine, and kidney. We investigated the rate of penetration, mode of fixation, extent...... performed equally well on all tissues tested. While several of the commercial fixatives appeared to preserve liver tissue at 200x, the preservation of kidney, intestinal villi, and smooth muscle was unacceptable. Histological distortion, cell shrinkage and vacuolization were prominent when the substitutes...

  3. Smart Phones and their Substitutes

    DEFF Research Database (Denmark)

    Bødker, Mads; Gimpel, Gregory; Hedman, Jonas

    2009-01-01

    our understanding of the role of substitutes, device content fit issues, and implications for business models by asking the question: What is an effective business model to address the relationship between user preference and the fit of the smart phone and everyday task? The field study data suggest......Drawing on data from a longitudinal field study, this paper investigates the influence of existing, better and stand-alone technology substitutes on the use of smart phones. By applying prospect theory, media richness theory, and business model literature, the purpose of this paper is to improve...... the need for business models to recognize that adoption decisions are reference-dependent and strongly influenced by the fit between task and smart phone....

  4. Substituting Quantum Entanglement for Communication

    OpenAIRE

    Cleve, Richard; Buhrman, Harry

    1997-01-01

    We show that quantum entanglement can be used as a substitute for communication when the goal is to compute a function whose input data is distributed among remote parties. Specifically, we show that, for a particular function among three parties (each of which possesses part of the function's input), a prior quantum entanglement enables one of them to learn the value of the function with only two bits of communication occurring among the parties, whereas, without quantum entanglement, three ...

  5. Bone marrow derived cell-seeded extracellular matrix: A novel biomaterial in the field of wound management

    OpenAIRE

    V. Remya; Naveen Kumar; Sharma, A. K.; Mathew, Dayamon D.; Mamta Negi; S.K. Maiti; Sameer Shrivastava; S. Sonal; KURADE, N.P.

    2014-01-01

    Aim: Extensive or irreversible damage to the skin often requires additional skin substitutes for reconstruction. Biomaterials have become critical components in the development of effective new medical therapies for wound care. Materials and Methods: In the present study, a cell matrix construct (bone marrow-derived cells (BMdc) seeded extracellular matrix [ECM]) was used as a biological substitute for the repair of full-thickness skin wound. ECM was developed by decellularizing fish swim ...

  6. Geometric realization for substitution tilings

    CERN Document Server

    Barge, Marcy

    2011-01-01

    Given an n-dimensional substitution whose associated linear expansion is unimodular and hyperbolic, we use elements of the one-dimensional integer \\v{C}ech cohomology of the associated tiling space to construct a finite-to-one semi-conjugacy, called geometric realization, between the substitution induced dynamics and an invariant set of a hyperbolic toral automorphism. If the linear expansion satisfies a Pisot family condition and the rank of the module of generalized return vectors equals the generalized degree of the linear expansion, the image of geometric realization is the entire torus and coincides with the map onto the maximal equicontinuous factor of the translation action on the tiling space. We are led to formulate a higher-dimensional generalization of the Pisot Substitution Conjecture: If the linear expansion satisfies the Pisot family condition and the rank of the one-dimensional cohomology of the tiling space equals the generalized degree of the linear expansion, then the translation action on t...

  7. 40 CFR 721.3360 - Substituted ethanolamine.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted ethanolamine. 721.3360... Substances § 721.3360 Substituted ethanolamine. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted ethanolamine (PMN P-91-490)...

  8. 24 CFR 220.253 - Substitute mortgagors.

    Science.gov (United States)

    2010-04-01

    ... Contract Rights and Obligations-Homes § 220.253 Substitute mortgagors. (a) Selling mortgagor. The mortgagee... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Substitute mortgagors. 220.253... the Commissioner's approval of a substitute mortgagor, as provided by this section. (b)...

  9. 24 CFR 221.252 - Substitute mortgagors.

    Science.gov (United States)

    2010-04-01

    ... Cost Homes § 221.252 Substitute mortgagors. (a) Selling mortgagor. The mortgagee may effect the release... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Substitute mortgagors. 221.252... approval of a substitute mortgagor, as provided by this section. (b) Purchasing mortgagor. The...

  10. International Evidence on Sectoral Interfuel Substitution

    OpenAIRE

    Serletis, Apostolos; Timilsina, Govinda R.; Vasetsky, Olexandr

    2010-01-01

    This paper estimates interfuel substitution elasticities in selected developing and industrialized economies at the sector level. In doing so, it employs state-of-the-art techniques in microeconometrics, particularly the locally flexible normalized quadratic functional form, and provides evidence consistent with neoclassical microeconomic theory. The results indicate that the interfuel substitution elasticities are consistently below unity, revealing the limited ability to substitute between ...

  11. 40 CFR 721.5867 - Substituted phenol.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted phenol. 721.5867 Section... Substances § 721.5867 Substituted phenol. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance generically identified as substituted phenol (PMNs P-89-1125,...

  12. Substitutes for School Nurses in Illinois

    Science.gov (United States)

    Vollinger, Linda Jeno; Bergren, Martha Dewey; Belmonte-Mann, Frances

    2011-01-01

    The purpose of this descriptive study was to explore utilization of nurse substitutes in the school setting in Illinois. The literature described personnel who staff the school health office in the absence of the school nurse and the barriers to obtaining nurse substitutes. There were no empirical studies conducted on school nurse substitutes in…

  13. 40 CFR 721.323 - Substituted acrylamide.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted acrylamide. 721.323... Substances § 721.323 Substituted acrylamide. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance generically identified as substituted acrylamide (PMN P-90-1687)...

  14. Substituted Indoleacetic Acids Tested in Tissue Cultures

    DEFF Research Database (Denmark)

    Engvild, Kjeld Christensen

    1978-01-01

    Monochloro substituted IAA inhibited shoot induction in tobacco tissue cultures about as much as IAA. Dichloro substituted IAA inhibited shoot formation less. Other substituted IAA except 5-fluoro- and 5-bromoindole-3-acetic acid were less active than IAA. Callus growth was quite variable and not...... and not correlated with auxin strength measured in the Avena coleoptile test....

  15. Matrix metalloproteinases and epileptogenesis.

    Science.gov (United States)

    Ikonomidou, Chrysanthy

    2014-12-01

    Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate cell death, aberrant network rewiring, and neuroinflammation and prevent development of epilepsy. PMID:26567100

  16. Fuzzy vulnerability matrix

    International Nuclear Information System (INIS)

    The so-called vulnerability matrix is used in the evaluation part of the probabilistic safety assessment for a nuclear power plant, during the containment event trees calculations. This matrix is established from what is knows as Numerical Categories for Engineering Judgement. This matrix is usually established with numerical values obtained with traditional arithmetic using the set theory. The representation of this matrix with fuzzy numbers is much more adequate, due to the fact that the Numerical Categories for Engineering Judgement are better represented with linguistic variables, such as 'highly probable', 'probable', 'impossible', etc. In the present paper a methodology to obtain a Fuzzy Vulnerability Matrix is presented, starting from the recommendations on the Numerical Categories for Engineering Judgement. (author)

  17. Double coincidence matrix

    International Nuclear Information System (INIS)

    To increase the accuracy of discrimination of true coincidences against the background of accidental ones, circuit has been developed which operates on the principle of dynamic equalization of resolution times of two coincidence circuits. The flowsheet of a 4x6 double-coincidence matrix is given. The principal elements of the matrix are commutators and output signal shapers. The matrix uses 138-series microcircuits. The resolution time of coincidence circuits is 10 ns, the dead time is 25 ns. The results of testing the matrix during experiments under conditions of a high background of accidental coincidences (70-90%) have shown that the accuracy of discrimination of true coincidences with the help of the double-coincidence matrix approximates the accuracy of time-to-digital converters within the limits of the statistical accuracy

  18. Fermionic matrix models

    CERN Document Server

    Semenoff, Gordon W; Semenoff, Gordon W; Szabo, Richard J

    1996-01-01

    We review a class of matrix models whose degrees of freedom are matrices with anticommuting elements. We discuss the properties of the adjoint fermion one-, two- and gauge invariant D-dimensional matrix models at large-N and compare them with their bosonic counterparts which are the more familiar Hermitian matrix models. We derive and solve the complete sets of loop equations for the correlators of these models and use these equations to examine critical behaviour. The topological large-N expansions are also constructed and their relation to other aspects of modern string theory such as integrable hierarchies is discussed. We use these connections to discuss the applications of these matrix models to string theory and induced gauge theories. We argue that as such the fermionic matrix models may provide a novel generalization of the discretized random surface representation of quantum gravity in which the genus sum alternates and the sums over genera for correlators have better convergence properties than thei...

  19. Matrix comparison, Part 2

    DEFF Research Database (Denmark)

    Schneider, Jesper Wiborg; Borlund, Pia

    2007-01-01

    The present two-part article introduces matrix comparison as a formal means for evaluation purposes in informetric studies such as cocitation analysis. In the first part, the motivation behind introducing matrix comparison to informetric studies, as well as two important issues influencing...... such comparisons, matrix generation, and the composition of proximity measures, are introduced and discussed. In this second part, the authors introduce and thoroughly demonstrate two related matrix comparison techniques the Mantel test and Procrustes analysis, respectively. These techniques can compare...... and evaluate the degree of monotonicity between different proximity measures or their ordination results. In common with these techniques is the application of permutation procedures to test hypotheses about matrix resemblances. The choice of technique is related to the validation at hand. In the case...

  20. Amino acid "little Big Bang": Representing amino acid substitution matrices as dot products of Euclidian vectors

    Directory of Open Access Journals (Sweden)

    Zimmermann Karel

    2010-01-01

    Full Text Available Abstract Background Sequence comparisons make use of a one-letter representation for amino acids, the necessary quantitative information being supplied by the substitution matrices. This paper deals with the problem of finding a representation that provides a comprehensive description of amino acid intrinsic properties consistent with the substitution matrices. Results We present a Euclidian vector representation of the amino acids, obtained by the singular value decomposition of the substitution matrices. The substitution matrix entries correspond to the dot product of amino acid vectors. We apply this vector encoding to the study of the relative importance of various amino acid physicochemical properties upon the substitution matrices. We also characterize and compare the PAM and BLOSUM series substitution matrices. Conclusions This vector encoding introduces a Euclidian metric in the amino acid space, consistent with substitution matrices. Such a numerical description of the amino acid is useful when intrinsic properties of amino acids are necessary, for instance, building sequence profiles or finding consensus sequences, using machine learning algorithms such as Support Vector Machine and Neural Networks algorithms.

  1. The nuclear reaction matrix

    Energy Technology Data Exchange (ETDEWEB)

    Krenciglowa, E.M.; Kung, C.L.; Kuo, T.T.S.; Osnes, E.

    1976-09-24

    Different definitions of the reaction matrix G appropriate to the calculation of nuclear structure are reviewed and discussed. Qualitative physical arguments are presented in support of a two-step calculation of the G-matrix for finite nuclei. In the first step the high-energy excitations are included using orthogonalized plane-wave intermediate states, and in the second step the low-energy excitations are added in, using harmonic oscillator intermediate states. Accurate calculations of G-matrix elements for nuclear structure calculations in the Aapprox. =18 region are performed following this procedure and treating the Pauli exclusion operator Q/sub 2//sub p/ by the method of Tsai and Kuo. The treatment of Q/sub 2//sub p/, the effect of the intermediate-state spectrum and the energy dependence of the reaction matrix are investigated in detail. The present matrix elements are compared with various matrix elements given in the literature. In particular, close agreement is obtained with the matrix elements calculated by Kuo and Brown using approximate methods. (AIP)

  2. Faces of matrix models

    CERN Document Server

    Morozov, A

    2012-01-01

    Partition functions of eigenvalue matrix models possess a number of very different descriptions: as matrix integrals, as solutions to linear and non-linear equations, as tau-functions of integrable hierarchies and as special-geometry prepotentials, as result of the action of W-operators and of various recursions on elementary input data, as gluing of certain elementary building blocks. All this explains the central role of such matrix models in modern mathematical physics: they provide the basic "special functions" to express the answers and relations between them, and they serve as a dream model of what one should try to achieve in any other field.

  3. Elementary matrix theory

    CERN Document Server

    Eves, Howard

    1980-01-01

    The usefulness of matrix theory as a tool in disciplines ranging from quantum mechanics to psychometrics is widely recognized, and courses in matrix theory are increasingly a standard part of the undergraduate curriculum.This outstanding text offers an unusual introduction to matrix theory at the undergraduate level. Unlike most texts dealing with the topic, which tend to remain on an abstract level, Dr. Eves' book employs a concrete elementary approach, avoiding abstraction until the final chapter. This practical method renders the text especially accessible to students of physics, engineeri

  4. Patience of matrix games

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Arnsfelt; Ibsen-Jensen, Rasmus; Podolskii, Vladimir V.;

    2013-01-01

    For matrix games we study how small nonzero probability must be used in optimal strategies. We show that for image win–lose–draw games (i.e. image matrix games) nonzero probabilities smaller than image are never needed. We also construct an explicit image win–lose game such that the unique optimal...... strategy uses a nonzero probability as small as image. This is done by constructing an explicit image nonsingular image matrix, for which the inverse has only nonnegative entries and where some of the entries are of value image....

  5. Mueller matrix differential decomposition.

    Science.gov (United States)

    Ortega-Quijano, Noé; Arce-Diego, José Luis

    2011-05-15

    We present a Mueller matrix decomposition based on the differential formulation of the Mueller calculus. The differential Mueller matrix is obtained from the macroscopic matrix through an eigenanalysis. It is subsequently resolved into the complete set of 16 differential matrices that correspond to the basic types of optical behavior for depolarizing anisotropic media. The method is successfully applied to the polarimetric analysis of several samples. The differential parameters enable one to perform an exhaustive characterization of anisotropy and depolarization. This decomposition is particularly appropriate for studying media in which several polarization effects take place simultaneously. PMID:21593943

  6. Pesticide-Exposure Matrix

    Science.gov (United States)

    The "Pesticide-exposure Matrix" was developed to help epidemiologists and other researchers identify the active ingredients to which people were likely exposed when their homes and gardens were treated for pests in past years.

  7. The Hill Interaction Matrix

    Science.gov (United States)

    Hill, William Fawcett

    1971-01-01

    Leadership style, group composition, and group development are simultaneously quantified through the use of the matrix. It represents an attempt to objectify the art of group therapy. Comment by Richard C. Rank follows. (Author)

  8. Matrix Big Brunch

    OpenAIRE

    Bedford, J; Papageorgakis, C.; Rodriguez-Gomez, D.; Ward, J.

    2007-01-01

    Following the holographic description of linear dilaton null Cosmologies with a Big Bang in terms of Matrix String Theory put forward by Craps, Sethi and Verlinde, we propose an extended background describing a Universe including both Big Bang and Big Crunch singularities. This belongs to a class of exact string backgrounds and is perturbative in the string coupling far away from the singularities, both of which can be resolved using Matrix String Theory. We provide a simple theory capable of...

  9. Matrix string interactions

    OpenAIRE

    Periwal, Vipul; Tafjord, Oyvind

    1998-01-01

    String configurations have been identified in compactified Matrix theory at vanishing string coupling. We show how the interactions of these strings are determined by the Yang-Mills gauge field on the worldsheet. At finite string coupling, this suggests the underlying dynamics is not well-approximated as a theory of strings. This may explain why string perturbation theory diverges badly, while Matrix string perturbation theory presumably has a perturbative expansion with properties similar to...

  10. Metal matrix Composites

    OpenAIRE

    Pradeep K. Rohatgi

    1993-01-01

    This paper reviews the world wide upsurge in metal matrix composite research and development activities with particular emphasis on cast metal-matrix particulate composites. Extensive applications of cast aluminium alloy MMCs in day-to-day use in transportation as well as durable good industries are expected to advance rapidly in the next decade. The potential for extensive application of cast composites is very large in India, especially in the areas of transportation, energy and elec...

  11. Matrix fractional systems

    Science.gov (United States)

    Tenreiro Machado, J. A.

    2015-08-01

    This paper addresses the matrix representation of dynamical systems in the perspective of fractional calculus. Fractional elements and fractional systems are interpreted under the light of the classical Cole-Cole, Davidson-Cole, and Havriliak-Negami heuristic models. Numerical simulations for an electrical circuit enlighten the results for matrix based models and high fractional orders. The conclusions clarify the distinction between fractional elements and fractional systems.

  12. The Matrix Organization Revisited

    DEFF Research Database (Denmark)

    Gattiker, Urs E.; Ulhøi, John Parm

    1999-01-01

    This paper gives a short overview of matrix structure and technology management. It outlines some of the characteristics and also points out that many organizations may actualy be hybrids (i.e. mix several ways of organizing to allocate resorces effectively).......This paper gives a short overview of matrix structure and technology management. It outlines some of the characteristics and also points out that many organizations may actualy be hybrids (i.e. mix several ways of organizing to allocate resorces effectively)....

  13. Ding-Iohara-Miki symmetry of network matrix models

    CERN Document Server

    Mironov, A; Zenkevich, Y

    2016-01-01

    Ward identities in the most general "network matrix model" can be described in terms of the Ding-Iohara-Miki algebras (DIM). This confirms an expectation that such algebras and their various limits/reductions are the relevant substitutes/deformations of the Virasoro/W-algebra for (q,t) and (q_1,q_2,q_3) deformed network matrix models. Exhaustive for these purposes should be the Pagoda triple-affine elliptic DIM, which corresponds to networks associated with 6d gauge theories with adjoint matter (double elliptic systems). We provide some details on elliptic qq-characters.

  14. Bosonic Matrix Theory and Matrix Dbranes

    OpenAIRE

    Chaudhuri, Shyamoli

    2002-01-01

    We develop new tools for an in-depth study of our recent proposal for Matrix Theory. We construct the anomaly-free and finite planar continuum limit of the ground state with SO(2^{13}) symmetry matching with the tadpole and tachyon free IR stable high temperature ground state of the open and closed bosonic string. The correspondence between large N limits and spacetime effective actions is demonstrated more generally for an arbitrary D25brane ground state which might include brane-antibrane p...

  15. Spectral Properties of Substituted Coumarins in Solution and Polymer Matrices

    Directory of Open Access Journals (Sweden)

    Jana Donovalová

    2012-03-01

    Full Text Available The absorption and fluorescence spectra of substituted coumarins (2-oxo-2H-chromenes were investigated in solvents and in polymer matrices. The substitutions involved were: (1 by groups with varying electron donating ability such as CH3, OCH3 and N(CH32, mainly, but not exclusively, in positions 7 and (2, by either CHO or 4-PhNHCONHN=CH- in position 3. While the spectra of non-substituted coumarin-3-carbaldehyde has absorptions at approximately 305 and 350 nm, substitution at position 7 leads to remarkable changes in the shape of the absorption spectrum and shifts the absorption to a longer wavelength. Similarly, the replacement of the formyl group with a semicarbazide group substantially influences the shape of the absorption spectrum, and coumarins which have only N(CH32 in position 7 experience small changes. These changes are associated with the increasing intramolecular charge transfer (ICT character and increasing conjugation length of the chromophoric system, respectively, in the studied molecules. The fluorescence is almost negligible for derivatives which have H in this position. With increasing electron donating ability, and the possibility of a positive mesomeric (+M effect of the substituent in position 7 of the coumarin moiety, the fluorescence increases, and this increase is most intense when N(CH32 substitutes in this position, for both 3-substituted derivatives. Spectral measurements of the studied coumarins in polymer matrices revealed that the absorption and fluorescence maxima lay within the maxima for solvents, and that coumarins yield more intense fluorescence in polymer matrices than when they are in solution. The quantum yield of derivatives which have a dimethylamino group in position 7 in polymer matrices approaches 1, and the fluorescence lifetime is within the range of 0.5–4 ns. The high quantum yield of 7-dimethylamino derivatives qualifies them as laser dyes which have kF higher than knr in the given medium. This

  16. Histological Features and Biocompatibility of Bone and Soft Tissue Substitutes in the Atrophic Alveolar Ridge Reconstruction

    Directory of Open Access Journals (Sweden)

    Carlo Maiorana

    2016-01-01

    Full Text Available The reconstruction of the atrophic alveolar ridges for implant placement is today a common procedure in dentistry daily practice. The surgical reconstruction provides for the optimization of the supporting bone for the implants and a restoration of the amount of keratinized gingiva for esthetic and functional reasons. In the past, tissue regeneration has been performed with autogenous bone and free gingival or connective tissue grafts. Nowadays, bone substitutes and specific collagen matrix allow for a complete restoration of the atrophic ridge without invasive harvesting procedures. A maxillary reconstruction of an atrophic ridge by means of tissue substitutes and its histological features are then presented.

  17. Formation of substituted oxa- and azarhodacyclobutanes.

    Science.gov (United States)

    Dauth, Alexander; Rigling, Carla; Tsoung, Jennifer; Love, Jennifer A

    2013-12-01

    The preparation of substituted oxa- and azarhodacyclobutanes is reported. After exchange of ethylene with a variety of unsymmetrically and symmetrically substituted alkenes, the corresponding rhodium-olefin complexes were oxidized with H2O2 and PhINTs (Ts=p-toluenesulfonyl) to yield the substituted oxa- and azarhodacyclobutanes, respectively. Oxarhodacyclobutanes could be prepared with excellent selectivity for incorporation of the oxygen atom on the more substituted carbon atom of the alkene. At the same time, azarhodacyclobutanes showed good-to-excellent selectivity for heteroatom incorporation on the less substituted carbon. Furthermore, it was shown that steric modifications of the ancillary ligand have a significant influence on the selectivity of Rh-olefin complex formation as well as formation of the substituted azametallacycles.

  18. Trends in Substitution Models of Molecular Evolution

    Directory of Open Access Journals (Sweden)

    Miguel eArenas

    2015-10-01

    Full Text Available Substitution models of evolution describe the process of genetic variation through fixed mutations and constitute the basis of the evolutionary analysis at the molecular level. Almost forty years after the development of first substitution models, highly sophisticated and data-specific substitution models continue emerging with the aim of better mimicking real evolutionary processes. Here I describe current trends in substitution models of DNA, codon and amino acid sequence evolution, including advantages and pitfalls of the most popular models. The perspective concludes that despite the large number of currently available substitution models, further research is required for more realistic modeling, especially for DNA coding and amino acid data. Additionally, the development of more accurate complex models should be coupled with new implementations and improvements of methods and frameworks for substitution model selection and downstream evolutionary analysis.

  19. Dehalogenation of aromatics by nucleophilic aromatic substitution.

    Science.gov (United States)

    Sadowsky, Daniel; McNeill, Kristopher; Cramer, Christopher J

    2014-09-16

    Nucleophilic aromatic substitution has been implicated as a mechanism for both the biotic and abiotic hydrodehalogenation of aromatics. Two mechanisms for the aqueous dehalogenation of aromatics involving nucleophilic aromatic substitution with hydride as a nucleophile are investigated using a validated density functional and continuum solvation protocol. For chlorinated and brominated aromatics, nucleophilic addition ortho to carbon-halogen bonds via an anionic intermediate is predicted to be the preferred mechanism in the majority of cases, while concerted substitution is predicted to be preferred for most fluorinated aromatics. Nucleophilic aromatic substitution reactions with the hydroxide and hydrosulfide anions as nucleophiles are also investigated and compared.

  20. Matrix Information Geometry

    CERN Document Server

    Bhatia, Rajendra

    2013-01-01

    This book is an outcome of the Indo-French Workshop on Matrix Information Geometries (MIG): Applications in Sensor and Cognitive Systems Engineering, which was held in Ecole Polytechnique and Thales Research and Technology Center, Palaiseau, France, in February 23-25, 2011. The workshop was generously funded by the Indo-French Centre for the Promotion of Advanced Research (IFCPAR).  During the event, 22 renowned invited french or indian speakers gave lectures on their areas of expertise within the field of matrix analysis or processing. From these talks, a total of 17 original contribution or state-of-the-art chapters have been assembled in this volume. All articles were thoroughly peer-reviewed and improved, according to the suggestions of the international referees. The 17 contributions presented  are organized in three parts: (1) State-of-the-art surveys & original matrix theory work, (2) Advanced matrix theory for radar processing, and (3) Matrix-based signal processing applications.  

  1. Monodromy Substitutions and Rational Blowdowns

    CERN Document Server

    Endo, Hisaaki; van Horn-Morris, Jeremy

    2010-01-01

    We introduce several new families of relations in the mapping class groups of planar surfaces, each equating two products of right-handed Dehn twists. The interest of these relations lies in their geometric interpretation in terms of rational blowdowns of 4-manifolds, specifically via monodromy substitution in Lefschetz fibrations. The simplest example is the lantern relation, already shown by the first author and Gurtas to correspond to rational blowdown along a -4 sphere; here we give relations that extend that result to realize the "generalized" rational blowdowns of Fintushel-Stern and Park by monodromy subsitution, as well as several of the families of rational blowdowns discovered by Stipsicz-Szab\\'o-Wahl.

  2. Substitution dynamical systems spectral analysis

    CERN Document Server

    Queffélec, Martine

    2010-01-01

    This volume mainly deals with the dynamics of finitely valued sequences, and more specifically, of sequences generated by substitutions and automata. Those sequences demonstrate fairly simple combinatorical and arithmetical properties and naturally appear in various domains. As the title suggests, the aim of the initial version of this book was the spectral study of the associated dynamical systems: the first chapters consisted in a detailed introduction to the mathematical notions involved, and the description of the spectral invariants followed in the closing chapters. This approach, combined with new material added to the new edition, results in a nearly self-contained book on the subject. New tools - which have also proven helpful in other contexts - had to be developed for this study. Moreover, its findings can be concretely applied, the method providing an algorithm to exhibit the spectral measures and the spectral multiplicity, as is demonstrated in several examples. Beyond this advanced analysis, many...

  3. Controversial issues of maternity substitution

    Directory of Open Access Journals (Sweden)

    Andy Pușcă

    2009-06-01

    Full Text Available Substitute maternity consists in a woman carrying a pregnancy (the implant of an embryo, at therequest of a sterile couple, most of the times in exchange of a sum of money, with her commitment tounconditionally give away the newborn after birth to the couple she concluded the agreement with. Manycontroversies emerged in what concerns the contract between the sterile couple and the carrying mother,especially when this contract is by onerous title, which happens in most of the cases. In that a civil contract? Is ita sales contract for the child? Is it a contract to provide services? Is it body marketing? Between total prohibitionand excessive liberalism, the middle way, which is the regulation according to ethical religious, cultural andsocial norms of each community, represents a realistic solution.

  4. Relaxing the Molecular Clock to Different Degrees for Different Substitution Types.

    Science.gov (United States)

    Lee, Hui-Jie; Rodrigue, Nicolas; Thorne, Jeffrey L

    2015-08-01

    Rates of molecular evolution can vary over time. Diverse statistical techniques for divergence time estimation have been developed to accommodate this variation. These typically require that all sequence (or codon) positions at a locus change independently of one another. They also generally assume that the rates of different types of nucleotide substitutions vary across a phylogeny in the same way. This permits divergence time estimation procedures to employ an instantaneous rate matrix with relative rates that do not differ among branches. However, previous studies have suggested that some substitution types (e.g., CpG to TpG changes in mammals) are more clock-like than others. As has been previously noted, this is biologically plausible given the mutational mechanism of CpG to TpG changes. Through stochastic mapping of sequence histories from context-independent substitution models, our approach allows for context-dependent nucleotide substitutions to change their relative rates over time. We apply our approach to the analysis of a 0.15 Mb intergenic region from eight primates. In accord with previous findings, we find comparatively little rate variation over time for CpG to TpG substitutions but we find more for other substitution types. We conclude by discussing the limitations and prospects of our approach.

  5. Biodentine-a novel dentinal substitute for single visit apexification.

    Science.gov (United States)

    Nayak, Gurudutt; Hasan, Mohammad Faiz

    2014-05-01

    Use of an apical plug in management of cases with open apices has gained popularity in recent years. Biodentine, a new calcium silicate-based material has recently been introduced as a dentine substitute, whenever original dentine is damaged. This case report describes single visit apexification in a maxillary central incisor with necrotic pulp and open apex using Biodentine as an apical barrier, and a synthetic collagen material as an internal matrix. Following canal cleaning and shaping, calcium hydroxide was placed as an intracanal medicament for 1 mon. This was followed by placement of small piece of absorbable collagen membrane beyond the root apex to serve as matrix. An apical plug of Biodentine of 5 mm thickness was placed against the matrix using pre-fitted hand pluggers. The remainder of canal was back-filled with thermoplasticized gutta-percha and access cavity was restored with composite resin followed by all-ceramic crown. One year follow-up revealed restored aesthetics and function, absence of clinical signs and symptoms, resolution of periapical rarefaction, and a thin layer of calcific tissue formed apical to the Biodentine barrier. The positive clinical outcome in this case is encouraging for the use of Biodentine as an apical plug in single visit apexification procedures.

  6. MATLAB matrix algebra

    CERN Document Server

    Pérez López, César

    2014-01-01

    MATLAB is a high-level language and environment for numerical computation, visualization, and programming. Using MATLAB, you can analyze data, develop algorithms, and create models and applications. The language, tools, and built-in math functions enable you to explore multiple approaches and reach a solution faster than with spreadsheets or traditional programming languages, such as C/C++ or Java. MATLAB Matrix Algebra introduces you to the MATLAB language with practical hands-on instructions and results, allowing you to quickly achieve your goals. Starting with a look at symbolic and numeric variables, with an emphasis on vector and matrix variables, you will go on to examine functions and operations that support vectors and matrices as arguments, including those based on analytic parent functions. Computational methods for finding eigenvalues and eigenvectors of matrices are detailed, leading to various matrix decompositions. Applications such as change of bases, the classification of quadratic forms and ...

  7. Finite Temperature Matrix Theory

    CERN Document Server

    Meana, M L; Peñalba, J P; Meana, Marco Laucelli; Peñalba, Jesús Puente

    1998-01-01

    We present the way the Lorentz invariant canonical partition function for Matrix Theory as a light-cone formulation of M-theory can be computed. We explicitly show how when the eleventh dimension is decompactified, the N=1 eleven dimensional SUGRA partition function appears. From this particular analysis we also clarify the question about the discernibility problem when making statistics with supergravitons (the N! problem) in Matrix black hole configurations. We also provide a high temperature expansion which captures some structure of the canonical partition function when interactions amongst D-particles are on. The connection with the semi-classical computations thermalizing the open superstrings attached to a D-particle is also clarified through a Born-Oppenheimer approximation. Some ideas about how Matrix Theory would describe the complementary degrees of freedom of the massless content of eleven dimensional SUGRA are also discussed.

  8. Dynamic Matrix Rank

    DEFF Research Database (Denmark)

    Frandsen, Gudmund Skovbjerg; Frandsen, Peter Frands

    2009-01-01

    We consider maintaining information about the rank of a matrix under changes of the entries. For n×n matrices, we show an upper bound of O(n1.575) arithmetic operations and a lower bound of Ω(n) arithmetic operations per element change. The upper bound is valid when changing up to O(n0.575) entries...... in a single column of the matrix. We also give an algorithm that maintains the rank using O(n2) arithmetic operations per rank one update. These bounds appear to be the first nontrivial bounds for the problem. The upper bounds are valid for arbitrary fields, whereas the lower bound is valid for algebraically...... closed fields. The upper bound for element updates uses fast rectangular matrix multiplication, and the lower bound involves further development of an earlier technique for proving lower bounds for dynamic computation of rational functions....

  9. DIY Bertin Matrix

    OpenAIRE

    Perin, Charles; Le Goc, Mathieu; Di Vozzo, Romain; Fekete, Jean-Daniel; Dragicevic, Pierre

    2015-01-01

    In this paper, we relate the iterative fabrication of a physical Bertin Matrix. Jacques Bertin designed and refined such devices over 10 years (1970–1980) and five iterations of what he called Dominos 1–5. For the purpose of an exhibit dedicated to Bertin's work during VIS 2014 in Paris, we designed an improved version of such device by leveraging modern fabrication possibilities and in particular a laser cutter. We describe the process, iterations and improvements of our matrix, and report l...

  10. Reduced Google matrix

    CERN Document Server

    Frahm, K M

    2016-01-01

    Using parallels with the quantum scattering theory, developed for processes in nuclear and mesoscopic physics and quantum chaos, we construct a reduced Google matrix $G_R$ which describes the properties and interactions of a certain subset of selected nodes belonging to a much larger directed network. The matrix $G_R$ takes into account effective interactions between subset nodes by all their indirect links via the whole network. We argue that this approach gives new possibilities to analyze effective interactions in a group of nodes embedded in a large directed networks. Possible efficient numerical methods for the practical computation of $G_R$ are also described.

  11. Elementary matrix algebra

    CERN Document Server

    Hohn, Franz E

    2012-01-01

    This complete and coherent exposition, complemented by numerous illustrative examples, offers readers a text that can teach by itself. Fully rigorous in its treatment, it offers a mathematically sound sequencing of topics. The work starts with the most basic laws of matrix algebra and progresses to the sweep-out process for obtaining the complete solution of any given system of linear equations - homogeneous or nonhomogeneous - and the role of matrix algebra in the presentation of useful geometric ideas, techniques, and terminology.Other subjects include the complete treatment of the structur

  12. A nonsupersymmetric matrix orbifold

    OpenAIRE

    Banks, Tom; Motl, Lubos

    1999-01-01

    We construct the matrix description for a twisted version of the IIA string theory on S^1 with fermions antiperiodic around a spatial circle. The result is a 2+1-dimensional U(N) x U(N) nonsupersymmetric Yang-Mills theory with fermionic matter transforming in the (N,Nbar). The two U(N)'s are exchanged if one goes around a twisted circle of the worldvolume. Relations with Type 0 theories are explored and we find Type 0 matrix string limits of our gauge theory. We argue however that most of the...

  13. Complex matrix model duality

    Energy Technology Data Exchange (ETDEWEB)

    Brown, T.W.

    2010-11-15

    The same complex matrix model calculates both tachyon scattering for the c=1 non-critical string at the self-dual radius and certain correlation functions of half-BPS operators in N=4 super- Yang-Mills. It is dual to another complex matrix model where the couplings of the first model are encoded in the Kontsevich-like variables of the second. The duality between the theories is mirrored by the duality of their Feynman diagrams. Analogously to the Hermitian Kontsevich- Penner model, the correlation functions of the second model can be written as sums over discrete points in subspaces of the moduli space of punctured Riemann surfaces. (orig.)

  14. Complex matrix model duality

    International Nuclear Information System (INIS)

    The same complex matrix model calculates both tachyon scattering for the c=1 non-critical string at the self-dual radius and certain correlation functions of half-BPS operators in N=4 super- Yang-Mills. It is dual to another complex matrix model where the couplings of the first model are encoded in the Kontsevich-like variables of the second. The duality between the theories is mirrored by the duality of their Feynman diagrams. Analogously to the Hermitian Kontsevich- Penner model, the correlation functions of the second model can be written as sums over discrete points in subspaces of the moduli space of punctured Riemann surfaces. (orig.)

  15. Matrixed business support comparison study.

    Energy Technology Data Exchange (ETDEWEB)

    Parsons, Josh D.

    2004-11-01

    The Matrixed Business Support Comparison Study reviewed the current matrixed Chief Financial Officer (CFO) division staff models at Sandia National Laboratories. There were two primary drivers of this analysis: (1) the increasing number of financial staff matrixed to mission customers and (2) the desire to further understand the matrix process and the opportunities and challenges it creates.

  16. 24 CFR 235.206 - Substitute mortgagors.

    Science.gov (United States)

    2010-04-01

    ... MORTGAGE INSURANCE AND ASSISTANCE PAYMENTS FOR HOME OWNERSHIP AND PROJECT REHABILITATION Contract Rights and Obligations-Homes for Lower Income Families § 235.206 Substitute mortgagors. (a) Selling mortgagor... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Substitute mortgagors....

  17. Multisensory integration, sensory substitution and visual rehabilitation

    DEFF Research Database (Denmark)

    Proulx, Michael J; Ptito, Maurice; Amedi, Amir

    2014-01-01

    Sensory substitution has advanced remarkably over the past 35 years since first introduced to the scientific literature by Paul Bach-y-Rita. In this issue dedicated to his memory, we describe a collection of reviews that assess the current state of neuroscience research on sensory substitution, v......, visual rehabilitation, and multisensory processes....

  18. PERFORMANCE OF PULVERIZED SLAG-SUBSTITUTED CEMENT

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The Portland cement is equivalently substituted by slag micropowders with various specific areas. The workability,activity and acid-corrosion resistance of the slag-substituted cements are investigated,the activation of gypsum is discussed,also the porosity and pore distribution of mortars of the slag micropowders cement are determined by mercury intrusion porosimetry.

  19. Biomechanical properties of four dermal substitutes

    Institute of Scientific and Technical Information of China (English)

    ZHANG Guo-an; NING Fang-gang; ZHAO Nan-ming

    2007-01-01

    @@ Many kinds of cell-free dermal substitutes have been developed during the past several years, however,their biomechanical properties, including hysteresis,stress relaxation, creep, and non-linear stress-strain, are still unknown. In this study, we tested these biomechanical characteristics of four dermal substitutes,and compared them with those of fresh human skin (FHS).

  20. Type Substitution for Object-Oriented Programming

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff; Palsberg, Jens

    1990-01-01

    Genericity allows the substitution of types in a class. This is usually obtained through parameterized classes, although they are inflexible since any class can be inherited but is not in itself parameterized. We suggest a new genericity mechanism, type substitution, which is a subclassing concep...

  1. 29 CFR 500.216 - Substituted service.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Substituted service. 500.216 Section 500.216 Labor... Service § 500.216 Substituted service. (a) Pursuant to section 102(5) of the Act, the Secretary, when so designated by a court, shall accept service of summons in any action arising under the Act or...

  2. Event matrix system

    International Nuclear Information System (INIS)

    The number of background events in nuclear and particle physics experiments which use multiwire proportional chambers can be extremely high. Using a computer to resolve these events results in a high deadtime for the experiment. A fast matrix system for decreasing the number of background events is described in this report. 4 figures

  3. Matrix Embedded Organic Synthesis

    Science.gov (United States)

    Kamakolanu, U. G.; Freund, F. T.

    2016-05-01

    In the matrix of minerals such as olivine, a redox reaction of the low-z elements occurs. Oxygen is oxidized to the peroxy state while the low-Z-elements become chemically reduced. We assign them a formula [CxHyOzNiSj]n- and call them proto-organics.

  4. Challenging the CSCW matrix

    DEFF Research Database (Denmark)

    Jørnø, Rasmus Leth Vergmann; Gynther, Karsten; Christensen, Ove

    2014-01-01

    useful information, we question whether the axis of time and space comprising the matrix pertains to relevant defining properties of the tools, technology or learning environments to which they are applied. Subsequently we offer an example of an Adobe Connect e-learning session as an illustration...

  5. Matrix model holography

    OpenAIRE

    Ortiz, Thomas; Samtleben, Henning; Tsimpis, Dimitrios

    2014-01-01

    We set up the formalism of holographic renormalization for the matter-coupled two-dimensional maximal supergravity that captures the low-lying fluctuations around the non-conformal D0-brane near-horizon geometry. As an application we compute holographically one- and two-point functions of the BFSS matrix quantum mechanics and its supersymmetric $SO(3)\\times SO(6)$ deformation.

  6. Constructing the matrix

    Science.gov (United States)

    Elliott, John

    2012-09-01

    As part of our 'toolkit' for analysing an extraterrestrial signal, the facility for calculating structural affinity to known phenomena must be part of our core capabilities. Without such a resource, we risk compromising our potential for detection and decipherment or at least causing significant delay in the process. To create such a repository for assessing structural affinity, all known systems (language parameters) need to be structurally analysed to 'place' their 'system' within a relational communication matrix. This will need to include all known variants of language structure, whether 'living' (in current use) or ancient; this must also include endeavours to incorporate yet undeciphered scripts and non-human communication, to provide as complete a picture as possible. In creating such a relational matrix, post-detection decipherment will be assisted by a structural 'map' that will have the potential for 'placing' an alien communication with its nearest known 'neighbour', to assist subsequent categorisation of basic parameters as a precursor to decipherment. 'Universal' attributes and behavioural characteristics of known communication structure will form a range of templates (Elliott, 2001 [1] and Elliott et al., 2002 [2]), to support and optimise our attempt at categorising and deciphering the content of an extraterrestrial signal. Detection of the hierarchical layers, which comprise intelligent, complex communication, will then form a matrix of calculations that will ultimately score affinity through a relational matrix of structural comparison. In this paper we develop the rationales and demonstrate functionality with initial test results.

  7. Substitution between cars within the household

    DEFF Research Database (Denmark)

    De Borger, Bruno; Mulalic, Ismir; Rouwendal, Jan

    2016-01-01

    In this paper we study the demand for car kilometres in two-car households, focusing on the substitution between cars of different fuel efficiency in response to fuel price changes. We use a large sample of detailed Danish data on two-car households to estimate – for each car owned by the household...... – own and cross-price effects of increases in fuel costs per kilometre. The empirical results show that failure to capture substitution between cars within the household can result in substantial misspecification biases. Ignoring substitution, the basic model yielded fuel price elasticities of 0.......98 and 1.41 for the primary and secondary cars, respectively. Accounting for substitution effects, these figures reduce to, respectively, 0.32 and 0.45. Consistent with substitution behaviour, we find that the fuel price elasticity of fuel demand exceeds the elasticity of kilometre demands with respect...

  8. Substitutional impurity in the graphene quantum dots

    Science.gov (United States)

    Sierański, K.; Szatkowski, J.

    2015-09-01

    The process of formation of the localized defect states due to substitutional impurity in sp2-bonded graphene quantum dot is considered using a simple tight-binding-type calculation. We took into account the interaction of the quantum dot atoms surrounding the substitutional impurity from the second row of elements. To saturate the external dangling sp2 orbitals of the carbon additionally 18 hydrogen atoms were introduced. The chemical formula of the quantum dot is H18C51X, where X is the symbol of substitutional atom. The position of the localized levels is determined relative to the host-atoms (C) εp energies. We focused on the effect of substitutional doping by the B, N and O on the eigenstate energies and on the total energy change of the graphene dots including for O the effect of lattice distorsion. We conclude that B, N, and O can form stable substitutional defects in graphene quantum dot.

  9. Aluminum substitution in goethite in lake ore

    Directory of Open Access Journals (Sweden)

    Carlson, L.

    1995-06-01

    Full Text Available The extent of substitution of Fe by Al in goethite in 32 lake ore samples collected from 11 lakes in Finland varied between 0 and 23 mol-%. The data indicated a negative relationship between Al-substitution and the particle size of lake ore. Differences in the Al-substitution were apparent between sampling sites, suggesting that kinetic and environmental variation in lake ore formation influences the substitution. Non-substituted goethite is formed in coarse-grained sediments with locally high concentrations of Fe due to iron-rich springs. Unit cell edge lengths and volumes of goethite varied as function of Al-subsitution but deviated from the Vegard relationship towards higher values.

  10. Identification of the Inorganic Pyrophosphate Metabolizing, ATP Substituting Pathway in Mammalian Spermatozoa

    OpenAIRE

    Young-Joo Yi; Miriam Sutovsky; Chelsey Kennedy; Peter Sutovsky

    2012-01-01

    Inorganic pyrophosphate (PPi) is generated by ATP hydrolysis in the cells and also present in extracellular matrix, cartilage and bodily fluids. Fueling an alternative pathway for energy production in cells, PPi is hydrolyzed by inorganic pyrophosphatase (PPA1) in a highly exergonic reaction that can under certain conditions substitute for ATP-derived energy. Recombinant PPA1 is used for energy-regeneration in the cell-free systems used to study the zymology of ATP-dependent ubiquitin-proteas...

  11. Evaluation of dermal substitute in a novel co-transplantation model with autologous epidermal sheet.

    Directory of Open Access Journals (Sweden)

    Guofeng Huang

    Full Text Available The development of more and more new dermal substitutes requires a reliable and effective animal model to evaluate their safety and efficacy. In this study we constructed a novel animal model using co-transplantation of autologous epidermal sheets with dermal substitutes to repair full-thickness skin defects. Autologous epidermal sheets were obtained by digesting the basement membrane (BM and dermal components from rat split-thickness skins in Dispase II solution (1.2 u/ml at 4 °C for 8, 10 and 12 h. H&E, immunohistochemical and live/dead staining showed that the epidermal sheet preserved an intact epidermis without any BM or dermal components, and a high percentage of viable cells (92.10 ± 4.19% and P63 positive cells (67.43 ± 4.21% under an optimized condition. Porcine acellular dermal matrixes were co-transplanted with the autologous epidermal sheets to repair full-thickness skin defects in Sprague-Dawley rats. The epidermal sheets survived and completely re-covered the wounds within 3 weeks. Histological staining showed that the newly formed stratified epidermis attached directly onto the dermal matrix. Inflammatory cell infiltration and vascularization of the dermal matrix were not significantly different from those in the subcutaneous implantation model. Collagen IV and laminin distributed continuously at the epidermis and dermal matrix junction 4 weeks after transplantation. Transmission electron microscopy further confirmed the presence of continuous lamina densa and hemidesmosome structures. This novel animal model can be used not only to observe the biocompatibility of dermal substitutes, but also to evaluate their effects on new epidermis and BM formation. Therefore, it is a simple and reliable model for evaluating the safety and efficacy of dermal substitutes.

  12. Electrotactile vision substitution for 3D trajectory following

    CERN Document Server

    Chekhchoukh, Abdessalem; Vuillerme, Nicolas; Payan, Yohan; Glade, Nicolas

    2013-01-01

    Navigation for blind persons represents a challenge for researchers in vision substitution. In this field, one of the used techniques to navigate is guidance. In this study, we develop a new approach for 3D trajectory following in which the requested task is to track a light path using computer input devices (keyboard and mouse) or a rigid body handled in front of a stereoscopic camera. The light path is visualized either on direct vision or by way of a electro-stimulation device, the Tongue Display Unit, a 12x12 matrix of electrodes. We improve our method by a series of experiments in which the effect of the modality of perception and that of the input device. Preliminary results indicated a close correlation between the stimulated and recorded trajectories.

  13. Modeling competitive substitution in a polyelectrolyte complex

    Science.gov (United States)

    Peng, B.; Muthukumar, M.

    2015-12-01

    We have simulated the invasion of a polyelectrolyte complex made of a polycation chain and a polyanion chain, by another longer polyanion chain, using the coarse-grained united atom model for the chains and the Langevin dynamics methodology. Our simulations reveal many intricate details of the substitution reaction in terms of conformational changes of the chains and competition between the invading chain and the chain being displaced for the common complementary chain. We show that the invading chain is required to be sufficiently longer than the chain being displaced for effecting the substitution. Yet, having the invading chain to be longer than a certain threshold value does not reduce the substitution time much further. While most of the simulations were carried out in salt-free conditions, we show that presence of salt facilitates the substitution reaction and reduces the substitution time. Analysis of our data shows that the dominant driving force for the substitution process involving polyelectrolytes lies in the release of counterions during the substitution.

  14. Modeling competitive substitution in a polyelectrolyte complex

    Energy Technology Data Exchange (ETDEWEB)

    Peng, B.; Muthukumar, M., E-mail: muthu@polysci.umass.edu [Department of Polymer Science and Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003 (United States)

    2015-12-28

    We have simulated the invasion of a polyelectrolyte complex made of a polycation chain and a polyanion chain, by another longer polyanion chain, using the coarse-grained united atom model for the chains and the Langevin dynamics methodology. Our simulations reveal many intricate details of the substitution reaction in terms of conformational changes of the chains and competition between the invading chain and the chain being displaced for the common complementary chain. We show that the invading chain is required to be sufficiently longer than the chain being displaced for effecting the substitution. Yet, having the invading chain to be longer than a certain threshold value does not reduce the substitution time much further. While most of the simulations were carried out in salt-free conditions, we show that presence of salt facilitates the substitution reaction and reduces the substitution time. Analysis of our data shows that the dominant driving force for the substitution process involving polyelectrolytes lies in the release of counterions during the substitution.

  15. XRF matrix corrections

    International Nuclear Information System (INIS)

    Full text: In order to obtain meaningful analytical information from an X-Ray Fluorescence spectrometer, it is necessary to correlate measured intensity values with sample concentrations. The ability to do this to a desired level of precision depends on taking care of a number of variables which influence measured intensity values. These variables include: the sample, which needs to be homogeneous, flat and critically thick to the analyte lines used for measurement; the spectrometer, which needs to perform any mechanical movements in a highly reproducible manner; the time taken to measure an analyte line, and the software, which needs to take care of detector dead-time, the contribution of background to the measured signal, the effects of line overlaps and matrix (absorption and enhancement) effects. This presentation will address commonly used correction procedures for matrix effects and their relative success in achieving their objective. Copyright (2002) Australian X-ray Analytical Association Inc

  16. A nonsupersymmetric matrix orbifold

    CERN Document Server

    Banks, T; Banks, Tom; Motl, Lubos

    2000-01-01

    We construct the matrix description for a twisted version of the IIA string theory on S^1 with fermions antiperiodic around a spatial circle. The result is a 2+1-dimensional U(N) x U(N) nonsupersymmetric Yang-Mills theory with fermionic matter transforming in the (N,Nbar). The two U(N)'s are exchanged if one goes around a twisted circle of the worldvolume. Relations with Type 0 theories are explored and we find Type 0 matrix string limits of our gauge theory. We argue however that most of these results are falsified by the absence of SUSY nonrenormalization theorems and that the models do not in fact have a sensible Lorentz invariant space time interpretation.

  17. Inside the NIKE matrix

    OpenAIRE

    BRENNER, BARBARA; Bodo B. Schlegelmilch; Ambos, Björn

    2013-01-01

    This case describes how Nike, a consumer goods company with an ever expanding portfolio and a tremendous brand value, manages the tradeoff between local responsiveness and global integration. In particular, the case highlights Nike's organizational structure that consists of a global matrix organization that is replicated at a regional level for the European market. While this organizational structure allows Nike to respond to local consumer tastes it also ensures that the company benefits f...

  18. Cultivation of Keratinocytes and Fibroblasts in a Three-Dimensional Bovine Collagen-Elastin Matrix (Matriderm® and Application for Full Thickness Wound Coverage in Vivo

    Directory of Open Access Journals (Sweden)

    Jasper Killat

    2013-07-01

    Full Text Available New skin substitutes for burn medicine or reconstructive surgery pose an important issue in plastic surgery. Matriderm® is a clinically approved three-dimensional bovine collagen-elastin matrix which is already used as a dermal substitute of full thickness burn wounds. The drawback of an avital matrix is the limited integration in full thickness skin defects, depending on the defect size. To further optimize this process, Matriderm® has also been studied as a matrix for tissue engineering of skin albeit long-term cultivation of the matrix with cells has been difficult. Cells have generally been seeded onto the matrix with high cell loss and minimal time-consuming migration. Here we developed a cell seeded skin equivalent after microtransfer of cells directly into the matrix. First, cells were cultured, and microinjected into Matriderm®. Then, cell viability in the matrix was determined by histology in vitro. As a next step, the skin substitute was applied in vivo into a full thickness rodent wound model. The wound coverage and healing was observed over a period of two weeks followed by histological examination assessing cell viability, proliferation and integration into the host. Viable and proliferating cells could be found throughout the entire matrix. The presented skin substitute resembles healthy skin in morphology and integrity. Based on this study, future investigations are planned to examine behaviour of epidermal stem cells injected into a collagen-elastin matrix under the aspects of establishment of stem cell niches and differentiation.

  19. Metal matrix Composites

    Directory of Open Access Journals (Sweden)

    Pradeep K. Rohatgi

    1993-10-01

    Full Text Available This paper reviews the world wide upsurge in metal matrix composite research and development activities with particular emphasis on cast metal-matrix particulate composites. Extensive applications of cast aluminium alloy MMCs in day-to-day use in transportation as well as durable good industries are expected to advance rapidly in the next decade. The potential for extensive application of cast composites is very large in India, especially in the areas of transportation, energy and electromechanical machinery; the extensive use of composites can lead to large savings in materials and energy, and in several instances, reduce environmental pollution. It is important that engineering education and short-term courses be organized to bring MMCs to the attention of students and engineering industry leaders. India already has excellent infrastructure for development of composites, and has a long track record of world class research in cast metal matrix particulate composites. It is now necessary to catalyze prototype and regular production of selected composite components, and get them used in different sectors, especially railways, cars, trucks, buses, scooters and other electromechanical machinery. This will require suitable policies backed up by funding to bring together the first rate talent in cast composites which already exists in India, to form viable development groups followed by setting up of production plants involving the process engineering capability already available within the country. On the longer term, cast composites should be developed for use in energy generation equipment, electronic packaging aerospace systems, and smart structures.

  20. Biologic and synthetic skin substitutes: An overview

    OpenAIRE

    Halim Ahmad; Khoo Teng; Shah Jumaat

    2010-01-01

    The current trend of burn wound care has shifted to more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. This has demanded the emergence of various skin substitutes in the management of acute burn injury as well as post burn reconstructions. Skin substitutes have important roles in the treatment of deep dermal and full thickness wounds of various aetiologies. At present, there is no ideal substitute in the market. Skin substit...

  1. The implementation of the import substitution strategy as the key to the development of export potential of industrial enterprises

    Directory of Open Access Journals (Sweden)

    T.V. Vashchenko

    2015-09-01

    Full Text Available The aim of the article. The article examines the preconditions and prospects of import substitution implementation by native producers of machine-building industry. It is based on the analysis of the different countries experiences in import substitution implementation for their economic growth and renovation. The rational explanation of the import substitution strategy formation and implementation at the management level of enterprise development is given. It allows to form more clearly the mission and objectives of enterprise’s effective management in an unstable external environment. The results of the analysis. The definition of the concept «industrial enterprise import substitution strategy» was formulated. The scientific and methodical aspects to the definition of the perspective directions for the import substitution strategy were developed. It allows to choose the best solution while considering the set of criteria. The matrix «the group's share in the product portfolio of an enterprise – the priority directions of the import substitution strategy realization» was developed using the method of hierarchies analysis. It helps to choose direction of the import substitution strategy implementation. According to the matrix it is possible to distinguish five zones in which it is ossible to choose the direction of the import substitution strategy implementation at industrial enterprises. Conclusions and directions of further researches. It is proved that for the purpose of determining of strategically effective directions of industrial enterprise development it is advisable to use principle of «sales funnel» phased selection of promising groups of product portfolio according to the criteria «degree of market risk and the additional ratio of return per unit of risk investment». The analysis of these indicators provides an opportunity to identify risk of attractive investment project and growth of the commodity portfolio groups

  2. Matrix Completions and Chordal Graphs

    Institute of Scientific and Technical Information of China (English)

    Kenneth John HARRISON

    2003-01-01

    In a matrix-completion problem the aim is to specifiy the missing entries of a matrix inorder to produce a matrix with particular properties. In this paper we survey results concerning matrix-completion problems where we look for completions of various types for partial matrices supported ona given pattern. We see that thc existence of completions of the required type often depends on thechordal properties of graphs associated with the pattern.

  3. DOES CURRENCY SUBSTITUTION AFFECT EXCHANGE RATE VOLATILITY?

    Directory of Open Access Journals (Sweden)

    Hisao Kumamoto

    2014-10-01

    Full Text Available This study investigates the impacts of the degree of currency substitution on nominal exchange rate volatility in seven countries (Indonesia, the Philippines, the Czech Republic, Hungary, Poland, Argentina, and Peru. We use the Threshold ARCH model to consider the ratchet effect of currency substitution and sample periods in the 2000s, during which time the economies of the sample countries stabilized, while the U.S. dollar and euro depreciated against other major currencies following the recent global financial crisis. The presented empirical analyses show that the degree of currency substitution has significant positive effects on the conditional variance of the depreciation rate of the nominal exchange rate in most sample countries. Moreover, a shock to the depreciation rate of the nominal exchange rate has asymmetric effects on the conditional variance, depending on the sign. One possible explanation for these differential effects is the existence of the ratchet effect of currency substitution.

  4. Synthesis of substituted 2-cyanoarylboronic esters

    DEFF Research Database (Denmark)

    Lysén, Morten; Hansen, Henriette M; Begtrup, Mikael;

    2006-01-01

    The synthesis of substituted 2-cyanoarylboronic esters is described via lithiation/in situ trapping of the corresponding methoxy-, trifluoromethyl-, fluoro-, chloro-, and bromobenzonitriles. The crude arylboronic esters were obtained in high yields and purities and with good regioselectivities....

  5. 47 CFR 76.110 - Substitutions.

    Science.gov (United States)

    2010-10-01

    ... blackout rules at § 76.111, substitute a program from any other television broadcast station. Programs... CABLE TELEVISION SERVICE Network Non-duplication Protection, Syndicated Exclusivity and Sports...

  6. Questioning nuclear waste substitution: a case study.

    Science.gov (United States)

    Marshall, Alan

    2007-03-01

    This article looks at the ethical quandaries, and their social and political context, which emerge as a result of international nuclear waste substitution. In particular it addresses the dilemmas inherent within the proposed return of nuclear waste owned by Japanese nuclear companies and currently stored in the United Kingdom. The UK company responsible for this waste, British Nuclear Fuels Limited (BNFL), wish to substitute this high volume intermediate-level Japanese-owned radioactive waste for a much lower volume of much more highly radioactive waste. Special focus is given to ethical problems that they, and the UK government, have not wished to address as they move forward with waste substitution. The conclusion is that waste substitution can only be considered an ethical practice if a set of moderating conditions are observed by all parties. These conditions are listed and, as of yet, they are not being observed.

  7. Nutrient-substituted hydroxyapatites: synthesis and characterization

    Science.gov (United States)

    Golden, D. C.; Ming, D. W.

    1999-01-01

    Incorporation of Mg, S, and plant-essential micronutrients into the structure of synthetic hydroxyapatite (HA) may be advantageous for closed-loop systems, such as will be required on Lunar and Martian outposts, because these apatites can be used as slow-release fertilizers. Our objective was to synthesize HA with Ca, P, Mg, S, Fe, Cu, Mn, Zn, Mo, B, and Cl incorporated into the structure, i.e., nutrient-substituted apatites. Hydroxyapatite, carbonate hydroxyapatite (CHA), nutrient-substituted hydroxyapatite (NHA), and nutrient-substituted carbonate hydroxyapatite (NCHA) were synthesized by precipitating from solution. Chemical and mineralogical analysis of precipitated samples indicated a considerable fraction of the added cations were incorporated into HA, without mineral impurities. Particle size of the HA was in the 1 to 40 nm range, and decreased with increased substitution of nutrient elements. The particle shape of HA was elongated in the c-direction in unsubstituted HA and NHA but more spherical in CHA and NCHA. The substitution of cations and anions in the HA structure was confirmed by the decrease of the d[002] spacing of HA with substitution of ions with an ionic radius less than that of Ca or P. The DTPA-extractable Cu ranged from 8 to 8429 mg kg-1, Zn ranged from 57 to 1279 mg kg-1, Fe from 211 to 2573 mg kg-1, and Mn from 190 to 1719 mg kg-1, depending on the substitution level of each element in HA. Nutrient-substituted HA has the potential to be used as a slow-release fertilizer to supply micronutrients, S, and Mg in addition to Ca and P.

  8. Substituted Pyrazinecarboxamides: Synthesis and Biological Evaluation

    OpenAIRE

    Katarina Kralova; Josef Jampilek; Vladimir Buchta; Jarmila Vinsova; Lukas Palek; Martin Dolezal

    2006-01-01

    Condensation of the corresponding chlorides of some substituted pyrazine-2-carboxylic acids (pyrazine-2-carboxylic acid, 6-chloropyrazine-2-carboxylic acid, 5-tert-butylpyrazine-2-carboxylic acid or 5-tert-butyl-6-chloropyrazine-2-carboxylic acid) withvarious ring-substituted aminothiazoles or anilines yielded a series of amides. Thesyntheses, analytical and spectroscopic data of thirty newly prepared compounds arepresented. Structure-activity relationships between the chemical structures and...

  9. Similartity Network For Semantic Web Services Substitution

    OpenAIRE

    Cherifi, Chantal

    2013-01-01

    Web services substitution is one of the most challenging tasks for automating the composition process of multiple Web services. It aims to improve performances and to deal efficiently with Web services failures. Many existing solutions have approached the problem through classification of substitutable Web services. To go a step further, we propose in this paper a network based approach where nodes are Web services operations and links join similar operations. Four similarity measures based o...

  10. SIMILARITY NETWORK FOR SEMANTIC WEB SERVICES SUBSTITUTION

    OpenAIRE

    Cherifi, Chantal

    2013-01-01

    Web services substitution is one of the most challenging tasks for automating the composition process of multiple Web services. It aims to improve performances and to deal efficiently with Web services failures. Many existing solutions have approached the problem through classification of substitutable Web services. To go a step further, we propose in this paper a network based approach where nodes are Web services operations and links join similar operations. Four similarity measures based o...

  11. Currency Substitution and Inflation in Peru

    OpenAIRE

    Liliana Rojas-Suárez

    1992-01-01

    This paper shows that there is a long-run relationship between the expected rate of depreciation in the black-market-exchange rate and the ratio of domestic to foreign money in Peru; that is, the hypothesis of currency substitution can explain the behavior of real holdings of money in Peru. The paper also shows that, while the importance of currency substitution as a transmission mechanism through which domestic policies affected the dynamics of inflation was relatively small during a period ...

  12. A Homeomorphism Invariant for Substitution Tiling Spaces

    OpenAIRE

    Ormes, Nic; Radin, Charles; Sadun, Lorenzo

    2000-01-01

    We derive a homeomorphism invariant for those tiling spaces which are made by rather general substitution rules on polygonal tiles, including those tilings, like the pinwheel, which contain tiles in infinitely many orientations. The invariant is a quotient of Cech cohomology, is easily computed directly from the substitution rule, and distinguishes many examples, including most pinwheel-like tiling spaces. We also introduce a module structure on cohomology which is very convenient as well as ...

  13. The cellulose resource matrix.

    Science.gov (United States)

    Keijsers, Edwin R P; Yılmaz, Gülden; van Dam, Jan E G

    2013-03-01

    The emerging biobased economy is causing shifts from mineral fossil oil based resources towards renewable resources. Because of market mechanisms, current and new industries utilising renewable commodities, will attempt to secure their supply of resources. Cellulose is among these commodities, where large scale competition can be expected and already is observed for the traditional industries such as the paper industry. Cellulose and lignocellulosic raw materials (like wood and non-wood fibre crops) are being utilised in many industrial sectors. Due to the initiated transition towards biobased economy, these raw materials are intensively investigated also for new applications such as 2nd generation biofuels and 'green' chemicals and materials production (Clark, 2007; Lange, 2007; Petrus & Noordermeer, 2006; Ragauskas et al., 2006; Regalbuto, 2009). As lignocellulosic raw materials are available in variable quantities and qualities, unnecessary competition can be avoided via the choice of suitable raw materials for a target application. For example, utilisation of cellulose as carbohydrate source for ethanol production (Kabir Kazi et al., 2010) avoids the discussed competition with easier digestible carbohydrates (sugars, starch) deprived from the food supply chain. Also for cellulose use as a biopolymer several different competing markets can be distinguished. It is clear that these applications and markets will be influenced by large volume shifts. The world will have to reckon with the increase of competition and feedstock shortage (land use/biodiversity) (van Dam, de Klerk-Engels, Struik, & Rabbinge, 2005). It is of interest - in the context of sustainable development of the bioeconomy - to categorize the already available and emerging lignocellulosic resources in a matrix structure. When composing such "cellulose resource matrix" attention should be given to the quality aspects as well as to the available quantities and practical possibilities of processing the

  14. The cellulose resource matrix.

    Science.gov (United States)

    Keijsers, Edwin R P; Yılmaz, Gülden; van Dam, Jan E G

    2013-03-01

    The emerging biobased economy is causing shifts from mineral fossil oil based resources towards renewable resources. Because of market mechanisms, current and new industries utilising renewable commodities, will attempt to secure their supply of resources. Cellulose is among these commodities, where large scale competition can be expected and already is observed for the traditional industries such as the paper industry. Cellulose and lignocellulosic raw materials (like wood and non-wood fibre crops) are being utilised in many industrial sectors. Due to the initiated transition towards biobased economy, these raw materials are intensively investigated also for new applications such as 2nd generation biofuels and 'green' chemicals and materials production (Clark, 2007; Lange, 2007; Petrus & Noordermeer, 2006; Ragauskas et al., 2006; Regalbuto, 2009). As lignocellulosic raw materials are available in variable quantities and qualities, unnecessary competition can be avoided via the choice of suitable raw materials for a target application. For example, utilisation of cellulose as carbohydrate source for ethanol production (Kabir Kazi et al., 2010) avoids the discussed competition with easier digestible carbohydrates (sugars, starch) deprived from the food supply chain. Also for cellulose use as a biopolymer several different competing markets can be distinguished. It is clear that these applications and markets will be influenced by large volume shifts. The world will have to reckon with the increase of competition and feedstock shortage (land use/biodiversity) (van Dam, de Klerk-Engels, Struik, & Rabbinge, 2005). It is of interest - in the context of sustainable development of the bioeconomy - to categorize the already available and emerging lignocellulosic resources in a matrix structure. When composing such "cellulose resource matrix" attention should be given to the quality aspects as well as to the available quantities and practical possibilities of processing the

  15. Substituting missing data in compositional analysis

    Energy Technology Data Exchange (ETDEWEB)

    Real, Carlos, E-mail: carlos.real@usc.es [Area de Ecologia, Departamento de Biologia Celular y Ecologia, Escuela Politecnica Superior, Universidad de Santiago de Compostela, 27002 Lugo (Spain); Angel Fernandez, J.; Aboal, Jesus R.; Carballeira, Alejo [Area de Ecologia, Departamento de Biologia Celular y Ecologia, Facultad de Biologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela (Spain)

    2011-10-15

    Multivariate analysis of environmental data sets requires the absence of missing values or their substitution by small values. However, if the data is transformed logarithmically prior to the analysis, this solution cannot be applied because the logarithm of a small value might become an outlier. Several methods for substituting the missing values can be found in the literature although none of them guarantees that no distortion of the structure of the data set is produced. We propose a method for the assessment of these distortions which can be used for deciding whether to retain or not the samples or variables containing missing values and for the investigation of the performance of different substitution techniques. The method analyzes the structure of the distances among samples using Mantel tests. We present an application of the method to PCDD/F data measured in samples of terrestrial moss as part of a biomonitoring study. - Highlights: > Missing values in multivariate data sets must be substituted prior to analysis. > The substituted values can modify the structure of the data set. > We developed a method to estimate the magnitude of the alterations. > The method is simple and based on the Mantel test. > The method allowed the identification of problematic variables in a sample data set. - A method is presented for the assessment of the possible distortions in multivariate analysis caused by the substitution of missing values.

  16. Matrix vector analysis

    CERN Document Server

    Eisenman, Richard L

    2005-01-01

    This outstanding text and reference applies matrix ideas to vector methods, using physical ideas to illustrate and motivate mathematical concepts but employing a mathematical continuity of development rather than a physical approach. The author, who taught at the U.S. Air Force Academy, dispenses with the artificial barrier between vectors and matrices--and more generally, between pure and applied mathematics.Motivated examples introduce each idea, with interpretations of physical, algebraic, and geometric contexts, in addition to generalizations to theorems that reflect the essential structur

  17. Matrix string partition function

    CERN Document Server

    Kostov, Ivan K; Kostov, Ivan K.; Vanhove, Pierre

    1998-01-01

    We evaluate quasiclassically the Ramond partition function of Euclidean D=10 U(N) super Yang-Mills theory reduced to a two-dimensional torus. The result can be interpreted in terms of free strings wrapping the space-time torus, as expected from the point of view of Matrix string theory. We demonstrate that, when extrapolated to the ultraviolet limit (small area of the torus), the quasiclassical expressions reproduce exactly the recently obtained expression for the partition of the completely reduced SYM theory, including the overall numerical factor. This is an evidence that our quasiclassical calculation might be exact.

  18. Exposed tibial bone after burns: Flap reconstruction versus dermal substitute.

    Science.gov (United States)

    Verbelen, Jozef; Hoeksema, Henk; Pirayesh, Ali; Van Landuyt, Koenraad; Monstrey, Stan

    2016-03-01

    A 44 years old male patient had suffered extensive 3rd degree burns on both legs, undergoing thorough surgical debridement, resulting in both tibias being exposed. Approximately 5 months after the incident he was referred to the Department of Plastic and Reconstructive Surgery of the University Hospital Gent, Belgium, to undergo flap reconstruction. Free flap surgery was performed twice on both lower legs but failed on all four occasions. In between flap surgery, a dermal substitute (Integra(®)) was applied, attempting to cover the exposed tibias with a layer of soft tissue, but also without success. In order to promote the development of granulation tissue over the exposed bone, small holes were drilled in both tibias with removal of the outer layer of the anterior cortex causing the bone to bleed and subsequently negative pressure wound therapy (NPWT) was applied. The limited granulation tissue resulting from this procedure was then covered with a dermal substitute (Glyaderm(®)), consisting of acellular human dermis with an average thickness of 0.25mm. This dermal substitute was combined with a NPWT-dressing, and then served as an extracellular matrix (ECM), guiding the distribution of granulation tissue over the remaining areas of exposed tibial bone. Four days after initial application of Glyaderm(®) combined with NPWT both tibias were almost completely covered with a thin coating of soft tissue. In order to increase the thickness of this soft tissue cover two additional layers of Glyaderm(®) were applied at intervals of approximately 1 week. One week after the last Glyaderm(®) application both wounds were autografted. The combination of an acellular dermal substitute (Glyaderm(®)) with negative pressure wound therapy and skin grafting proved to be an efficient technique to cover a wider area of exposed tibial bone in a patient who was not a candidate for free flap surgery. An overview is also provided of newer and simpler techniques for coverage of

  19. Currency Substitution and Government Revenue from Inflation Currency Substitution and Government Revenue from Inflation

    Directory of Open Access Journals (Sweden)

    C. Luis Ramírez-Rojas

    1986-03-01

    Full Text Available Currency Substitution and Government Revenue from Inflation The purpose of this paper is to show that in the case of an open economy the calculations of revenue-maximing rates of inflation have been made using a restrictive model that assumes that domestic residents can only substitute between domestic money and goods (and real assets. The paper demonstrates that once the effects of currency substitution, so common in developing countries, are taken into account, the inflation rate that maximizes the proceeds of the inflation tax can be quite lower than would be the case when currency substitution is ignored.

  20. Matrix algebra for linear models

    CERN Document Server

    Gruber, Marvin H J

    2013-01-01

    Matrix methods have evolved from a tool for expressing statistical problems to an indispensable part of the development, understanding, and use of various types of complex statistical analyses. This evolution has made matrix methods a vital part of statistical education. Traditionally, matrix methods are taught in courses on everything from regression analysis to stochastic processes, thus creating a fractured view of the topic. Matrix Algebra for Linear Models offers readers a unique, unified view of matrix analysis theory (where and when necessary), methods, and their applications. Written f

  1. [Guidelines for substitution treatments in prison populations].

    Science.gov (United States)

    Michel, L; Maguet, O

    2005-01-01

    Care access for the drug addict patients in prison (in particular for the treatments of substitution) in France is very unequal from one establishment to another. This reflects the great variability of the practices of substitution and especially the absence of consensus on the methods of adaptation of these practices to the prison environment. Because of difficulties expressed by prisoners and medical staff on this subject and of stakes (let us recall that approximately 30% of the prisoners are dependent or abusers of one or more psychoactive substances), the formulation of recommendations or of a good practices guide of substitution in prison appeared necessary. Work that we detail here answers a ordering of the Advisory Commission of the Treatments of Substitution (September 2001) whose authors are members. It was presented at the session April 2003. It results from the confrontation of a review of the literature (including legal texts and official reports concerning substitution, the organization of the care in prison environment and the lawful framework), with a vast investigation. The latter was carried out near medical staff (22 prisons), penitentiary staff (3 prisons, 27 people met including directors of these establishments) and prisoners (7 establishments, 28 prisoners met) in the form of individual talks (semi-directing interviews with evaluation of the type of existing device and its knowledge by the penitentiary staff and the prisoners; statement of the suggestions, needs and requests of the medical, penitentiary staffs and of the prisoners). In the whole visited prisons, 7.8% (870) of the prisoners received substitution treatments (6.35% by buprenorphine, 1.44% by methadone), representing a proportion of substituted drug addicts (870 substituted for an evaluation of 3,350 prisoners drug addicts among the 11,168 prisoners of the 22 visited prisons) notably lower than that in free environment (56%, ie 96,000 substituted for an evaluated population of

  2. Influence of waxy rice flour substitution for wheat flour on characteristics of batter and freeze-thawed cake.

    Science.gov (United States)

    Jongsutjarittam, Nisachon; Charoenrein, Sanguansri

    2013-09-12

    This study aimed to improve the freeze-thawed cake properties by10-20% waxy rice flour (WRF) substitution for wheat flour (WF). Viscosity of WRF-substituted batters was lower; consequently, trapped air was less uniformly distributed than WF batter. After five freeze-thaw cycles, firmness and enthalpy of melting retrograded amylopectin of WF- and WRF-substituted cakes increased and the matrix surrounding the air pores from SEM images was denser than in fresh-baked cakes. Sensory evaluation showed an increase in firmness and a decrease in firmness acceptability of freeze-thawed cakes. However, freeze-thawed cake with WRF substitution had significantly less firmness, less dense matrix and more acceptability than WF cake. This could have been due to a low amylose content of WRF and the spread of ruptured waxy rice starch granules around swollen wheat starch granules as observed by CLSM. Thus, WRF could be used for WF substitution to improve the firmness in freeze-thawed cake.

  3. A Sequential and Comprehensive Method for Effective Substitute Teaching

    Science.gov (United States)

    Byer, John L.

    2008-01-01

    This article dealt with methods for making substitute teaching more effective. The purpose was to articulate a sequential method for maximizing the effectiveness of substitute teaching while providing substitutes with a comprehensive method for diligently and flexibly earning respect and using reflection to continually improve substitute teaching.…

  4. Light cone matrix product

    Energy Technology Data Exchange (ETDEWEB)

    Hastings, Matthew B [Los Alamos National Laboratory

    2009-01-01

    We show how to combine the light-cone and matrix product algorithms to simulate quantum systems far from equilibrium for long times. For the case of the XXZ spin chain at {Delta} = 0.5, we simulate to a time of {approx} 22.5. While part of the long simulation time is due to the use of the light-cone method, we also describe a modification of the infinite time-evolving bond decimation algorithm with improved numerical stability, and we describe how to incorporate symmetry into this algorithm. While statistical sampling error means that we are not yet able to make a definite statement, the behavior of the simulation at long times indicates the appearance of either 'revivals' in the order parameter as predicted by Hastings and Levitov (e-print arXiv:0806.4283) or of a distinct shoulder in the decay of the order parameter.

  5. Matrix Graph Grammars

    CERN Document Server

    Velasco, Pedro Pablo Perez

    2008-01-01

    This book objective is to develop an algebraization of graph grammars. Equivalently, we study graph dynamics. From the point of view of a computer scientist, graph grammars are a natural generalization of Chomsky grammars for which a purely algebraic approach does not exist up to now. A Chomsky (or string) grammar is, roughly speaking, a precise description of a formal language (which in essence is a set of strings). On a more discrete mathematical style, it can be said that graph grammars -- Matrix Graph Grammars in particular -- study dynamics of graphs. Ideally, this algebraization would enforce our understanding of grammars in general, providing new analysis techniques and generalizations of concepts, problems and results known so far.

  6. Hyaluronan: A Matrix Component

    Science.gov (United States)

    Rügheimer, Louise

    2008-09-01

    The glucosaminoglycan hyaluronan is a key component of the extracellular matrix. It is a large, negatively charged molecule that can act as an ion exchange reservoir for positive ions. Hyaluronan is involved in renomedullary water handling through its water-binding capacity. In the renal medulla, the main source for hyaluronan production is the renomedullary interstitial cells. Hyaluronan synthases are found in the inner part of the plasma membrane and polymerize hyaluronan chains which are extruded into the extracellular space. Hyaluronidases are a family of enzymes involved in the degradation of hyaluronan. They have a wide range of properties, including differences in size, inhibitor sensitivities, catalytic mechanisms, substrate specificities and pH optima.

  7. Matrix Quantization of Turbulence

    CERN Document Server

    Floratos, Emmanuel

    2011-01-01

    Based on our recent work on Quantum Nambu Mechanics $\\cite{af2}$, we provide an explicit quantization of the Lorenz chaotic attractor through the introduction of Non-commutative phase space coordinates as Hermitian $ N \\times N $ matrices in $ R^{3}$. For the volume preserving part, they satisfy the commutation relations induced by one of the two Nambu Hamiltonians, the second one generating a unique time evolution. Dissipation is incorporated quantum mechanically in a self-consistent way having the correct classical limit without the introduction of external degrees of freedom. Due to its volume phase space contraction it violates the quantum commutation relations. We demonstrate that the Heisenberg-Nambu evolution equations for the Matrix Lorenz system develop fast decoherence to N independent Lorenz attractors. On the other hand there is a weak dissipation regime, where the quantum mechanical properties of the volume preserving non-dissipative sector survive for long times.

  8. Reconstruction of rabbit urethra using urethral extracellular matrix

    Institute of Scientific and Technical Information of China (English)

    杨嗣星; 姚颐; 胡云飞; 宋超; 王玲珑; 金化民

    2004-01-01

    Background Urethral reconstruction for both congenital and acquired etiologies remains a challenge for most urologic surgeons. Tissue engineering has been proposed as a strategy for urethral reconstruction. The purpose of This study was to determine whether a naturally derived extracellular matrix substitute developed for urethral reconstruction would be suitable for urethral repair in an animal model.Methods A urethral segmental defect was created in 20 male rabbits. The urethral extracellular matrix, obtained and processed from rabbit urethral tissue, was trimmed and transplanted to repair the urethral defect. Then, the regenerated segment was studied histologically by haematoxylin-eosin staining and Van Gieson staining at 10 days, 3 weeks, 6 weeks, and 24 weeks postoperation. Retrograde urethrography was used to evaluate the function of the regenerated urethras of 4 rabbits 10 and 24 weeks after the operation. The urodynamics of 4 rabbits from the experimental group and control group Ⅰ were assessed and compared. In addition, 4 experimental group rabbits were examined by a urethroscope 24 weeks after the operation.Results At 10 days after operation, epithelial cells had migrated from each side, and small vessels were observed in the extracellular matrix. The matrix and adjacent areas of the host tissue were infiltrated with inflammatory cells. The epithelium covered the extracellular matrix fully at 3 weeks postoperation. Well-formed smooth-muscle cells were first confirmed after 6 weeks, at which point the inflammatory cells had disappeared. At 24 weeks postoperation, the regenerated tissue was equivalent to the normal urethra. Urethrography and urodynamic evaluations showed that there was no difference between normal tissue and regenerated tissue.Conclusions Urethral extracellular matrix appears to be a useful material for urethral repair in rabbits. The matrix can be processed easily and has good characteristics for tissue handling and urethral function.

  9. Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.

    Science.gov (United States)

    Kolk, Andreas; Handschel, Jörg; Drescher, Wolf; Rothamel, Daniel; Kloss, Frank; Blessmann, Marco; Heiland, Max; Wolff, Klaus-Dietrich; Smeets, Ralf

    2012-12-01

    An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.

  10. Biodegradable and semi-biodegradable composite hydrogels as bone substitutes: morphology and mechanical characterization.

    Science.gov (United States)

    Sanginario, V; Ginebra, M P; Tanner, K E; Planell, J A; Ambrosio, L

    2006-05-01

    Biodegradable and semi-biodegradable composite hydrogels are proposed as bone substitutes. They consist of an hydrophilic biodegradable polymer (HYAFF 11) as matrix and two ceramic powders (alpha-TCP and HA) as reinforcement. Both components of these composites have been of great interest in biomedical applications due to their excellent biocompatibility and tissue interactions, however they have never been investigated as bone substitute composites. Morphological and mechanical analysis have shown that the two fillers behave in a very different way. In the HYAFF 11/alpha-TCP composite, alpha-TCP is able to hydrolyze in contact with water while in the HYAFF 11 matrix. As a result, the composite sets and hardens, and entangled CDHA crystals are formed in the hydrogel phase and increases in the mechanical properties are obtained. In the HYAFF11/HA composite the ceramic reinforcement acts as inert phase leading to lower mechanical properties. Both mechanical properties and microstructure analysis have demonstrated the possibility to design hydrophilic biodegradable composite structures for bone tissue substitution applications. PMID:16688585

  11. Spherical membranes in Matrix theory

    CERN Document Server

    Kabat, D; Kabat, Daniel; Taylor, Washington

    1998-01-01

    We consider membranes of spherical topology in uncompactified Matrix theory. In general for large membranes Matrix theory reproduces the classical membrane dynamics up to 1/N corrections; for certain simple membrane configurations, the equations of motion agree exactly at finite N. We derive a general formula for the one-loop Matrix potential between two finite-sized objects at large separations. Applied to a graviton interacting with a round spherical membrane, we show that the Matrix potential agrees with the naive supergravity potential for large N, but differs at subleading orders in N. The result is quite general: we prove a pair of theorems showing that for large N, after removing the effects of gravitational radiation, the one-loop potential between classical Matrix configurations agrees with the long-distance potential expected from supergravity. As a spherical membrane shrinks, it eventually becomes a black hole. This provides a natural framework to study Schwarzschild black holes in Matrix theory.

  12. QUALITATIVE RESEARCH ABOUT THE PROCESS OF MEDIATING OF SUBSTITUTE FAMILY CARE: REQUIREMENTS FOR SUBSTITUTE PARENTS

    Directory of Open Access Journals (Sweden)

    Kozáková Aneta

    2013-12-01

    Full Text Available Substitute Family Care is an institute for children when their parents, for whatever reason, are unable to care for the children themselves. This paper is concerned with substitute family care in the Czech Republic. The paper is specifically aimed at the process of mediating of the substitute family care. A social worker, in the process of mediating of the substitute family care, has a key role, nevertheless, the social worker co-operatives with other people involved, such as psychologists and medical examiners. People involved are abided by the law, different methodologies and recommendations, but even so they are highly benevolent when assessing claimant for substitute family care. The research problem is described in the introduction. The term of substitute family care is explained and the process of mediating of the substitute family care is described there. The issues of who else is interested in this process and what requirements are imposed on a claimant for substitute family care, are also described and explained in this chapter. Research methodology is described subsequently. The aim of the research is to describe how people involved in the process of mediating of the alternative family care perceive and interpret the requests asked of the claimant. The main and sub research questions are based on the aim of the research. Qualitative research strategy is applied and field research, as a type of research, is selected by Miovský. In the last part of the paper the interesting findings from the carried out research are interpreted and discussed. The very process of mediating of the substitute family care in the Moravian-Silesian Region is described. The attitude of the people involved towards the requirements imposed on substitute parents is also described. Sub-questions are answered in the end.

  13. Evaluation of lymphangiogenesis in acellular dermal matrix

    Directory of Open Access Journals (Sweden)

    Mario Cherubino

    2014-01-01

    Full Text Available Introduction: Much attention has been directed towards understanding the phenomena of angiogenesis and lymphangiogenesis in wound healing. Thanks to the manifold dermal substitute available nowadays, wound treatment has improved greatly. Many studies have been published about angiogenesis and cell invasion in INTEGRA® . On the other hand, the development of the lymphatic network in acellular dermal matrix (ADM is a more obscure matter. In this article, we aim to characterize the different phases of host cell invasion in ADM. Special attention was given to lymphangiogenic aspects. Materials and Methods: Among 57 rats selected to analyse the role of ADM in lymphangiogenesis, we created four groups. We performed an excision procedure on both thighs of these rats: On the left one we did not perform any action except repairing the borders of the wound; while on the right one we used INTEGRA® implant. The excision biopsy was performed at four different times: First group after 7 days, second after 14 days, third after 21 days and fourth after 28 days. For our microscopic evaluation, we used the classical staining technique of haematoxylin and eosin and a semi-quantitative method in order to evaluate cellularity counts. To assess angiogenesis and lymphangiogenesis development we employed PROX-1 Ab and CD31/PECAM for immunohistochemical analysis. Results: We found remarkable wound contraction in defects that healed by secondary intention while minor wound contraction was observed in defects treated with ADM. At day 7, optical microscopy revealed a more plentiful cellularity in the granulation tissue compared with the dermal regeneration matrix. The immunohistochemical process highlighted vascular and lymphatic cells in both groups. After 14 days a high grade of fibrosis was noticeable in the non-treated group. At day 21, both lymphatic and vascular endothelial cells were better developed in the group with a dermal matrix application. At day 28

  14. Substitution within the Danish printing industry

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Bøg, Carsten

    2009-01-01

    The implementation of the EU REACH regulation will most probably promote substitution within sectors handling a lot of different chemicals like the printing industry. With the aim of being at the cutting edge of this development the Danish EPA together with the Danish printing industry and IPU...... are running a substitution project. A major part of the work has been mapping the presence of chemicals which are potential candidates for substitution (e.g. PBT, CMR, vPvB, EDS) within the Danish printing industry and this work was recently finished. The mapping comprises a combination of a literature study...... according to Danish legislation (List of Undesirable Substances) and about 40 of these substances fulfil one or more of the criteria (e.g. CMR, EDS) for the REACH Annex XIV candidate list (authorisation). Three substances (phthalates) out of the first and recently published Annex XIV candidate list (in...

  15. Characteristics of fluid substitution in porous rocks

    Institute of Scientific and Technical Information of China (English)

    Li Shengjie

    2009-01-01

    Analysis of the effect of changes in fluid properties of rocks on the compressional-wave velocity VP and shear-wave velocity Vs is very important for understanding the rock physical properties, especially in oilfield exploration and development.The fluid substitution process was analyzed by using ultrasonic measurement and theoretical calculations.The results showed that the effect of fluid substitution on the rock elastic modulus was mainly controlled by fluid properties, saturation, and confining pressure.For a rock with specific properties and porosity, the result of theoretical prediction for fluid substitution accorded with the experimental result under high confining pressure (higher than 60 MPa for our experimental data), but failed to describe the trend of experimental result under low confining pressure and VP predicted by Gassmann's equation was higher than that measured by experiment.A higher porosity resulted in stronger sensitivity of the bulk modulus of saturated rocks to the change of fluid properties.

  16. Substitution between Cars within the Household

    DEFF Research Database (Denmark)

    de Borger, Bruno; Mulalic, Ismir; Rouwendal, Jan

    In this paper we study the demand for car kilometres in two-car households, focusing on the substitution between cars in response to fuel price changes. We use a large sample of detailed Danish data on two-car households to estimate—for each car owned by the household—own and cross-price effects...... of increases in fuel costs per kilometre. The empirical results show that failure to capture substitution between cars within the household can result in substantial misspecification biases. Ignoring substitution, we estimate fuel price elasticities of –0.81 and -0.65 for the primary and secondary cars...... efficient car, finding partial support for the underlying hypothesis. More importantly, the results of this extended model emphasize the importance of behavioural differences related to the position of the most fuel efficient car in the household, suggesting that households’ fuel efficiency choices...

  17. Homological Pisot Substitutions and Exact Regularity

    CERN Document Server

    Barge, Marcy; Jones, Leslie; Sadun, Lorenzo

    2010-01-01

    We consider one-dimensional substitution tiling spaces where the dilatation (stretching factor) is a degree d Pisot number, and where the first rational Cech cohomology is d-dimensional. We construct examples of such "homological Pisot" substitutions that do not have pure discrete spectra. These examples are not unimodular, and we conjecture that the coincidence rank must always divide a power of the norm of the dilatation. To support this conjecture, we show that homological Pisot substitutions exhibit an Exact Regularity Property (ERP), in which the number of occurrences of a patch for a return length is governed strictly by the length. The ERP puts strong constraints on the measure of any cylinder set in the corresponding tiling space.

  18. Linearized supergravity from Matrix theory

    CERN Document Server

    Kabat, D; Kabat, Daniel; Taylor, Washington

    1998-01-01

    We show that the linearized supergravity potential between two objects arising from the exchange of quanta with zero longitudinal momentum is reproduced to all orders in 1/r by terms in the one-loop Matrix theory potential. The essential ingredient in the proof is the identification of the Matrix theory quantities corresponding to moments of the stress tensor and membrane current. We also point out that finite-N Matrix theory violates the Equivalence Principle.

  19. Enhancing an R-matrix

    CERN Document Server

    MacKaay, M A

    1996-01-01

    In order to construct a representation of the tangle category one needs an enhanced R-matrix. In this paper we define a sufficient and necessary condition for enhancement that can be checked easily for any R-matrix. If the R-matrix can be enhanced, we also show how to construct the additional data that define the enhancement. As a direct consequence we find a sufficient condition for the construction of a knot invariant.

  20. Matrix elements of unstable states

    CERN Document Server

    Bernard, V; Meißner, U -G; Rusetsky, A

    2012-01-01

    Using the language of non-relativistic effective Lagrangians, we formulate a systematic framework for the calculation of resonance matrix elements in lattice QCD. The generalization of the L\\"uscher-Lellouch formula for these matrix elements is derived. We further discuss in detail the procedure of the analytic continuation of the resonance matrix elements into the complex energy plane and investigate the infinite-volume limit.

  1. Matrix Models and Gravitational Corrections

    CERN Document Server

    Dijkgraaf, R; Temurhan, M; Dijkgraaf, Robbert; Sinkovics, Annamaria; Temurhan, Mine

    2002-01-01

    We provide evidence of the relation between supersymmetric gauge theories and matrix models beyond the planar limit. We compute gravitational R^2 couplings in gauge theories perturbatively, by summing genus one matrix model diagrams. These diagrams give the leading 1/N^2 corrections in the large N limit of the matrix model and can be related to twist field correlators in a collective conformal field theory. In the case of softly broken SU(N) N=2 super Yang-Mills theories, we find that these exact solutions of the matrix models agree with results obtained by topological field theory methods.

  2. A matrix model for WZW

    Science.gov (United States)

    Dorey, Nick; Tong, David; Turner, Carl

    2016-08-01

    We study a U( N) gauged matrix quantum mechanics which, in the large N limit, is closely related to the chiral WZW conformal field theory. This manifests itself in two ways. First, we construct the left-moving Kac-Moody algebra from matrix degrees of freedom. Secondly, we compute the partition function of the matrix model in terms of Schur and Kostka polynomials and show that, in the large N limit, it coincides with the partition function of the WZW model. This same matrix model was recently shown to describe non-Abelian quantum Hall states and the relationship to the WZW model can be understood in this framework.

  3. A Matrix Model for WZW

    CERN Document Server

    Dorey, Nick; Turner, Carl

    2016-01-01

    We study a U(N) gauged matrix quantum mechanics which, in the large N limit, is closely related to the chiral WZW conformal field theory. This manifests itself in two ways. First, we construct the left-moving Kac-Moody algebra from matrix degrees of freedom. Secondly, we compute the partition function of the matrix model in terms of Schur and Kostka polynomials and show that, in the large $N$ limit, it coincides with the partition function of the WZW model. This same matrix model was recently shown to describe non-Abelian quantum Hall states and the relationship to the WZW model can be understood in this framework.

  4. Analysis of meat consumption based on the matrix of growth

    Directory of Open Access Journals (Sweden)

    Lakić Nada

    2008-01-01

    Full Text Available Using the matrix of growth it is possible to examine, in a specific way, structural relations of growth in order to discover the mutual influences of activities and their linking into systems. Considering that different sorts of meat can substitute one another in nutrition, during the observation of the dynamics of the consumption of a certain sort of meat, its change should be observed as a function of a scope of the consumption of other sorts of meat in the analyzed time period. This work's subject is an analysis of trends of the consumption of different sorts of meat in Central Serbia, in the period from 1994 to 2007, via the matrix of the consumption growth.

  5. Factor Input Substitution in Irish Manufacturing

    OpenAIRE

    Haller, Stefanie A.; Hyland, Marie

    2014-01-01

    We use a translog cost function to model production in the Irish manufacturing sector over the period from 1991 to 2009. We estimate both own- and cross-price elasticities and Morishima elasticities of substitution between capital, labour, materials and energy. We find that capital and energy are substitutes in the production process. Across all firms we find that a 1% rise in the price of energy is associated with an increase of 0.1% in the demand for capital. The Morishima elasticities, whi...

  6. Substitution between cars within the household

    DEFF Research Database (Denmark)

    De Borger, Bruno; Mulalic, Ismir; Rouwendal, Jan

    The purpose of this paper is to study to what extent two-car households substitute the use of their less fuel efficient car by the use of their more fuel efficient car after an increase in fuel prices. Based on a simple theoretical framework we use a large sample of detailed Danish data on two-car...... households to estimate, for each car owned by the household, own and cross-price effects of increases in fuel costs per kilometer. The empirical results point at important substitution effects, so that models that estimate responses to fuel prices on the implicit or explicit assumption of one car per...

  7. Substitution-diffusion based Image Cipher

    Directory of Open Access Journals (Sweden)

    Narendra K Pareek

    2011-03-01

    Full Text Available In this paper, a new image encryption scheme using a secret key of 128-bit size is proposed. In thealgorithm, image is partitioned into several key based dynamic blocks and further, each block passesthrough the eight rounds of diffusion as well as substitution process. In diffusion process, sequences ofblock pixels are rearranged within the block by a zigzag approach whereas block pixels are replaced withanother by using difference calculation of row and column in substitution process. Due to high order ofsubstitution and diffusion, common attacks like linear and differential cryptanalysis are infeasible. Theexperimental results show that the proposed technique is efficient and has high security features.

  8. Matrix Product Operators, Matrix Product States, and ab initio Density Matrix Renormalization Group algorithms

    CERN Document Server

    Chan, Garnet Kin-Lic; Nakatani, Naoki; Li, Zhendong; White, Steven R

    2016-01-01

    Current descriptions of the ab initio DMRG algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab-initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational par...

  9. Extracellular Matrix-Based Biohybrid Materials for Engineering Compliant, Matrix-Dense Tissues.

    Science.gov (United States)

    Bracaglia, Laura G; Fisher, John P

    2015-11-18

    An ideal tissue engineering scaffold should not only promote, but take an active role in, constructive remodeling and formation of site appropriate tissue. Extracellular matrix (ECM)-derived proteins provide unmatched cellular recognition, and therefore influence cellular response towards predicted remodeling behaviors. Materials built with only these proteins, however, can degrade rapidly or begin too weak to substitute for compliant, matrix-dense tissues. The focus of this Progress Report is on biohybrid materials that incorporate polymer components with ECM-derived proteins, to produce a substrate with desired mechanical and degradation properties, as well as actively guide tissue remodeling. Materials are described through four fabrication methods: 1) polymer and ECM-protein fibers woven together, 2) polymer and ECM proteins combined in a bilayer, 3) cell-built ECM on polymer scaffold, and 4) ECM proteins and polymers combined in a single hydrogel. Scaffolds from each fabrication method can achieve characteristics suitable for different types of tissue. In vivo testing has shown progressive remodeling in injury models, and suggests ECM-based biohybrid materials promote a prohealing immune response over single component alternatives. The prohealing immune response is associated with lasting success and long term host maintenance of the implant.

  10. Ceramic matrix composite article and process of fabricating a ceramic matrix composite article

    Science.gov (United States)

    Cairo, Ronald Robert; DiMascio, Paul Stephen; Parolini, Jason Robert

    2016-01-12

    A ceramic matrix composite article and a process of fabricating a ceramic matrix composite are disclosed. The ceramic matrix composite article includes a matrix distribution pattern formed by a manifold and ceramic matrix composite plies laid up on the matrix distribution pattern, includes the manifold, or a combination thereof. The manifold includes one or more matrix distribution channels operably connected to a delivery interface, the delivery interface configured for providing matrix material to one or more of the ceramic matrix composite plies. The process includes providing the manifold, forming the matrix distribution pattern by transporting the matrix material through the manifold, and contacting the ceramic matrix composite plies with the matrix material.

  11. On interfuel substitution : some international evidence

    OpenAIRE

    Serletis, Apostolos; Timilsina, Govinda; Vasetsky, Olexandr

    2009-01-01

    This paper estimates interfuel substitution elasticities in selected developing and industrialized economies at the national and sector levels. In doing so, it employs state-of-the-art techniques in microeconometrics, particularly the locally flexible normalized quadratic functional forms, and provides evidence consistent with neoclassical microeconomic theory. The results indicate that th...

  12. Elasticity of Substitution and Antidumping Measures

    DEFF Research Database (Denmark)

    Drud Hansen, Jørgen; Meinen, Philipp; Nielsen, Jørgen Ulff-Møller

    therefore also vary inversely with the elasticity of substitution at least for countries which have a strong focus on prices in the determination of their anti-dumping measures. We test this for ten countries from 1990 to 2009 using data on anti-dumping from Chad Bown (2010) and US-data at 8-digit level...

  13. Synthesis of enantiopure 3-substituted morpholines

    DEFF Research Database (Denmark)

    Bornholdt, Jan; Felding, Jakob; Kristensen, Jesper Langgaard

    2010-01-01

    Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very ...

  14. Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions

    OpenAIRE

    Nenortas, Elizabeth; Kulikowicz, Tomasz; Burri, Christian; Shapiro, Theresa A.

    2003-01-01

    Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid biosynthesis in trypanosomes, characteristics of topoisomerase II inhibition.

  15. Synthesis of Dialkyl-substituted Terminal Olefin

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Dialkyl-substituted terminal olefins were synthesized from the coupling reaction of αt-olefins which were catalyzed by zirconocene dichloride/methylalumoxane (MAO) catalyst system under mild condition. High yield was gained and no other oligmer was detected. It was found that the ratio of Al/Zr is responsible for the selectivity of product.

  16. 21 CFR 882.5910 - Dura substitute.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Dura substitute. 882.5910 Section 882.5910 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... surrounding the brain). (b) Classification. Class II (performance standards)....

  17. Capillary Electrophoresis of Substituted Benzoic Acids

    Science.gov (United States)

    Mills, Nancy S.; Spence, John D.; Bushey, Michelle M.

    2005-01-01

    A series of substituted benzoic acids (SBAs) are prepared by students. The pKa shift, a result of the electron-withdrawing or electron-donating characteristics of the subsistent is examined in reference to the electrophoretic migration behavior of benzoic acid.

  18. Trends in Autism Prevalence: Diagnostic Substitution Revisited

    Science.gov (United States)

    Coo, Helen; Ouellette-Kuntz, Helene; Lloyd, Jennifer E. V.; Kasmara, Liza; Holden, Jeanette J. A.; Lewis, M. E. Suzanne

    2008-01-01

    There has been little evidence to support the hypothesis that diagnostic substitution may contribute to increases in the administrative prevalence of autism. We examined trends in assignment of special education codes to British Columbia (BC) school children who had an autism code in at least 1 year between 1996 and 2004, inclusive. The proportion…

  19. Fast Fourier Transform-based Support Vector Machine for Subcellular Localization Prediction Using Different Substitution Models

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    There are approximately 109 proteins in a cell. A hotspot in bioinformatics is how to identify a protein's subcellular localization, if its sequence is known. In this paper, a method using fast Fourier transform-based support vector machine is developed to predict the subcellular localization of proteins from their physicochemical properties and structural parameters. The prediction accuracies reached 83% in prokaryotic organisms and 84% in eukaryotic organisms with the substitution model of the c-p-v matrix (c, composition; p, polarity; and v, molecular volume). The overall prediction accuracy was also evaluated using the "leave-one-out" jackknife procedure. The influence of the substitution model on prediction accuracy has also been discussed in the work. The source code of the new program is available on request from the authors.

  20. How to Study a Matrix

    Science.gov (United States)

    Jairam, Dharmananda; Kiewra, Kenneth A.; Kauffman, Douglas F.; Zhao, Ruomeng

    2012-01-01

    This study investigated how best to study a matrix. Fifty-three participants studied a matrix topically (1 column at a time), categorically (1 row at a time), or in a unified way (all at once). Results revealed that categorical and unified study produced higher: (a) performance on relationship and fact tests, (b) study material satisfaction, and…

  1. Matrix Analysis of Tracer Transport

    CERN Document Server

    Mills, Peter

    2015-01-01

    We review matrix methods as applied to tracer transport. Because tracer transport is linear, matrix methods are an ideal fit for the problem. In particular, solutions of linear, first-order systems of ordinary differential equations (ODEs) are reviewed as well as special properties of these solutions. Detailed derivations are included

  2. Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis.

    Science.gov (United States)

    Sun, Yao; Weng, Yuteng; Zhang, Chenyang; Liu, Yi; Kang, Chen; Liu, Zhongshuang; Jing, Bo; Zhang, Qi; Wang, Zuolin

    2015-12-04

    Proteoglycans play important roles in regulating osteogenesis. Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism. After glycosylation, an N-terminal fragment of DMP1 protein was identified as a new proteoglycan (DMP1-PG) in bone matrix. In vitro investigations showed that Ser(89) is the key glycosylation site in mouse DMP1. However, the specific role of DMP1 glycosylation is still not understood. In this study, a mutant DMP1 mouse model was developed in which the glycosylation site S(89) was substituted with G(89) (S89G-DMP1). The glycosylation level of DMP1 was down-regulated in the bone matrix of S89G-DMP1 mice. Compared with wild type mice, the long bones of S89G-DMP1 mice showed developmental changes, including the speed of bone remodeling and mineralization, the morphology and activities of osteocytes, and activities of both osteoblasts and osteoclasts. These findings indicate that glycosylation of DMP1 is a key posttranslational modification process during development and that DMP1-PG functions as an indispensable proteoglycan in osteogenesis.

  3. Machining of Metal Matrix Composites

    CERN Document Server

    2012-01-01

    Machining of Metal Matrix Composites provides the fundamentals and recent advances in the study of machining of metal matrix composites (MMCs). Each chapter is written by an international expert in this important field of research. Machining of Metal Matrix Composites gives the reader information on machining of MMCs with a special emphasis on aluminium matrix composites. Chapter 1 provides the mechanics and modelling of chip formation for traditional machining processes. Chapter 2 is dedicated to surface integrity when machining MMCs. Chapter 3 describes the machinability aspects of MMCs. Chapter 4 contains information on traditional machining processes and Chapter 5 is dedicated to the grinding of MMCs. Chapter 6 describes the dry cutting of MMCs with SiC particulate reinforcement. Finally, Chapter 7 is dedicated to computational methods and optimization in the machining of MMCs. Machining of Metal Matrix Composites can serve as a useful reference for academics, manufacturing and materials researchers, manu...

  4. Matrix convolution operators on groups

    CERN Document Server

    Chu, Cho-Ho

    2008-01-01

    In the last decade, convolution operators of matrix functions have received unusual attention due to their diverse applications. This monograph presents some new developments in the spectral theory of these operators. The setting is the Lp spaces of matrix-valued functions on locally compact groups. The focus is on the spectra and eigenspaces of convolution operators on these spaces, defined by matrix-valued measures. Among various spectral results, the L2-spectrum of such an operator is completely determined and as an application, the spectrum of a discrete Laplacian on a homogeneous graph is computed using this result. The contractivity properties of matrix convolution semigroups are studied and applications to harmonic functions on Lie groups and Riemannian symmetric spaces are discussed. An interesting feature is the presence of Jordan algebraic structures in matrix-harmonic functions.

  5. Multivariate Matrix-Exponential Distributions

    DEFF Research Database (Denmark)

    Bladt, Mogens; Nielsen, Bo Friis

    2010-01-01

    In this article we consider the distributions of non-negative random vectors with a joint rational Laplace transform, i.e., a fraction between two multi-dimensional polynomials. These distributions are in the univariate case known as matrix-exponential distributions, since their densities can be...... written as linear combinations of the elements in the exponential of a matrix. For this reason we shall refer to multivariate distributions with rational Laplace transform as multivariate matrix-exponential distributions (MVME). The marginal distributions of an MVME are univariate matrix......-exponential distributions. We prove a characterization that states that a distribution is an MVME distribution if and only if all non-negative, non-null linear combinations of the coordinates have a univariate matrix-exponential distribution. This theorem is analog to a well-known characterization theorem for the...

  6. Evaluation of the cytotoxicity of cell free dermal substitutes using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide method

    Institute of Scientific and Technical Information of China (English)

    NING Fang-gang; ZHANG Guo-an

    2010-01-01

    Background The cytotoxicity of dermal substitutes may be increased by the very processes used to deplete the cells. The present research aimed to investigate the method for monitoring the cytotoxicity of cell-free dermal substitutes using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method.Methods The cytotoxicity of four dermal substitutes was evaluated using the MTT method according to the standards set by the Chinese State Food and Drug Administration (SFDA). Swine acellular dermal matrix (SADM) and goat acellular dermal matrix (GADM) were produced using a repeated freeze-thaw method. Human dermal matrix glutaraldehyde composite (HADM-G) and SADM cross-linked with glutaraldehyde (SADM-G) were produced using conventional methods. Results The cytotoxicity of all dermal substitutes ranged from Grade 0 to Grade 1, meeting the standards of the Chinese FDA. The OD_(490) of both SADM and GADM was higher than that of either HADM-G or SADM-G (P<0.05). Conclusion Dermal substitutes produced by the freeze-thaw method are less cytotoxic than those produced using conventional methods.

  7. Currency Substitution and Inflation in Peru Currency Substitution and Inflation in Peru

    OpenAIRE

    Liliana Rojas-Suarez

    1992-01-01

    This paper shows that there is a long-run relationship between the expected rate of depreciation in the black-market-exchange rate and the ratio of domestic to foreign money in Peru: that is, the hypothesis of currency substitution can explain the behavior of real holdings of money in Peru. The paper also shows that, while, the importance of currency substitution as a transmission mechanism through which domestic policies affected the dynamics of inflation was relatively small during a period...

  8. Currency Substitution and the Regressivity of Inflationary Taxation Currency Substitution and the Regressivity of Inflationary Taxation

    Directory of Open Access Journals (Sweden)

    Federico A. Sturzeneger

    1992-03-01

    Full Text Available Currency Substitution and the Regressivity of Inflationary Taxation The purpose of this paper is to show that in the presence of financial adaptation or currency substitution. the inflation tax is extremely regressive. This regressivity arises from the existence of a fixed cost of switching to inflation-proof transactions technologies. This fixed cost makes it optimal only for those agents with sufficiently high incomes to switch out of domestic currency. The effects are illustrated and quantified for a particular case.

  9. Substitution treatment for opioid addicts in Germany

    Directory of Open Access Journals (Sweden)

    Gerlach Ralf

    2007-02-01

    Full Text Available Abstract Background After a long and controversial debate methadone maintenance treatment (MMT was first introduced in Germany in 1987. The number of patients in MMT – first low because of strict admission criteria – increased considerably since the 1990s up to some 65,000 at the end of 2006. In Germany each general practitioner (GP, who has completed an additional training in addiction medicine, is allowed to prescribe substitution drugs to opioid dependent patients. Currently 2,700 GPs prescribe substitution drugs. Psychosocial care should be made available to all MMT patients. Results The results of research studies and practical experiences clearly indicate that patients benefit substantially from MMT with improvements in physical and psychological health. MMT proves successful in attaining high retention rates (65 % to 85 % in the first years, up to 50 % after more than seven years and plays a major role in accessing and maintaining ongoing medical treatment for HIV and hepatitis. MMT is also seen as a vital factor in the process of social re-integration and it contributes to the reduction of drug related harms such as mortality and morbidity and to the prevention of infectious diseases. Some 10 % of MMT patients become drug-free in the long run. Methadone is the most commonly prescribed substitution medication in Germany, although buprenorphine is attaining rising importance. Access to MMT in rural areas is very patchy and still constitutes a problem. There are only few employment opportunities for patients participating in MMT, although regular employment is considered unanimously as a positive factor of treatment success. Substitution treatment in German prisons is heterogeneous in access and treatment modalities. Access is very patchy and the number of inmates in treatment is limited. Nevertheless, substitution treatment plays a substantial part in the health care system provided to drug users in Germany. Conclusion In Germany, a

  10. The Substitution Secant/Finite Difference Method for Large Scale Sparse Unconstrained Optimization

    Institute of Scientific and Technical Information of China (English)

    Hong-wei Zhang; Jun-xiang Li

    2005-01-01

    This paper studies a substitution secant/finite difference (SSFD) method for solving large scale sparse unconstrained optimization problems. This method is a combination of a secant method and a finite difference method, which depends on a consistent partition of the columns of the lower triangular part of the Hessian matrix. A q-superlinear convergence result and an r-convergence rate estimate show that this method has good local convergence properties. The numerical results show that this method may be competitive with some currently used algorithms.

  11. The matrix of inspiration

    Science.gov (United States)

    Oehlmann, Dietmar; Ohlmann, Odile M.; Danzebrink, Hans U.

    2005-04-01

    perform this exchange, as a matrix, understood as source, of new ideas.

  12. Containment Code Validation Matrix

    International Nuclear Information System (INIS)

    The Committee on the Safety of Nuclear Installations (CSNI) formed the CCVM (Containment Code Validation Matrix) task group in 2002. The objective of this group was to define a basic set of available experiments for code validation, covering the range of containment (ex-vessel) phenomena expected in the course of light and heavy water reactor design basis accidents and beyond design basis accidents/severe accidents. It was to consider phenomena relevant to pressurised heavy water reactor (PHWR), pressurised water reactor (PWR) and boiling water reactor (BWR) designs of Western origin as well as of Eastern European VVER types. This work would complement the two existing CSNI validation matrices for thermal hydraulic code validation (NEA/CSNI/R(1993)14) and In-vessel core degradation (NEA/CSNI/R(2001)21). The report initially provides a brief overview of the main features of a PWR, BWR, CANDU and VVER reactors. It also provides an overview of the ex-vessel corium retention (core catcher). It then provides a general overview of the accident progression for light water and heavy water reactors. The main focus is to capture most of the phenomena and safety systems employed in these reactor types and to highlight the differences. This CCVM contains a description of 127 phenomena, broken down into 6 categories: - Containment Thermal-hydraulics Phenomena; - Hydrogen Behaviour (Combustion, Mitigation and Generation) Phenomena; - Aerosol and Fission Product Behaviour Phenomena; - Iodine Chemistry Phenomena; - Core Melt Distribution and Behaviour in Containment Phenomena; - Systems Phenomena. A synopsis is provided for each phenomenon, including a description, references for further information, significance for DBA and SA/BDBA and a list of experiments that may be used for code validation. The report identified 213 experiments, broken down into the same six categories (as done for the phenomena). An experiment synopsis is provided for each test. Along with a test description

  13. Manufacturing Titanium Metal Matrix Composites by Consolidating Matrix Coated Fibres

    Institute of Scientific and Technical Information of China (English)

    Hua-Xin PENG

    2005-01-01

    Titanium metal matrix composites (TiMMCs) reinforced by continuous silicon carbide fibres are being developed for aerospace applications. TiMMCs manufactured by the consolidation of matrix-coated fibre (MCF) method offer optimum properties because of the resulting uniform fibre distribution, minimum fibre damage and fibre volume fraction control. In this paper, the consolidation of Ti-6Al-4V matrix-coated SiC fibres during vacuum hot pressing has been investigated. Experiments were carried out on multi-ply MCFs under vacuum hot pressing (VHP). In contrast to most of existing studies, the fibre arrangement has been carefully controlled either in square or hexagonal arraysthroughout the consolidated sample. This has enabled the dynamic consolidation behaviour of MCFs to be demonstrated by eliminating the fibre re-arrangement during the VHP process. The microstructural evolution of the matrix coating was reported and the deformation mechanisms involved were discussed.

  14. Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling.

    Science.gov (United States)

    Ashworth, J L; Murphy, G; Rock, M J; Sherratt, M J; Shapiro, S D; Shuttleworth, C A; Kielty, C M

    1999-05-15

    Fibrillin is the principal structural component of the 10-12 nm diameter elastic microfibrils of the extracellular matrix. We have previously shown that both fibrillin molecules and assembled microfibrils are susceptible to degradation by serine proteases. In this study, we have investigated the potential catabolic effects of six matrix metalloproteinases (MMP-2, MMP-3, MMP-9, MMP-12, MMP-13 and MMP-14) on fibrillin molecules and on intact fibrillin-rich microfibrils isolated from ciliary zonules. Using newly synthesized recombinant fibrillin molecules, major cleavage sites within fibrillin-1 were identified. In particular, the six different MMPs generated a major degradation product of approximately 45 kDa from the N-terminal region of the molecule, whereas treatment of truncated, unprocessed and furin-processed C-termini also generated large degradation products. Introduction of a single ectopia lentis-causing amino acid substitution (E2447K; one-letter symbols for amino acids) in a calcium-binding epidermal growth factor-like domain, predicted to disrupt calcium binding, markedly altered the pattern of C-terminal fibrillin-1 degradation. However, the fragmentation pattern of a mutant fibrillin-1 with a comparable E-->K substitution in an upstream calcium-binding epidermal growth factor-like domain was indistinguishable from wild-type molecules. Ultrastructural examination highlighted that fibrillin-rich microfibrils isolated from ciliary zonules were grossly disrupted by MMPs. This is the first demonstration that fibrillin molecules and fibrillin-rich microfibrils are degraded by MMPs and that certain amino acid substitutions change the fragmentation patterns. These studies have important implications for physiological and pathological fibrillin catabolism and for loss of connective tissue elasticity in ageing and disease.

  15. Canonical density matrix perturbation theory.

    Science.gov (United States)

    Niklasson, Anders M N; Cawkwell, M J; Rubensson, Emanuel H; Rudberg, Elias

    2015-12-01

    Density matrix perturbation theory [Niklasson and Challacombe, Phys. Rev. Lett. 92, 193001 (2004)] is generalized to canonical (NVT) free-energy ensembles in tight-binding, Hartree-Fock, or Kohn-Sham density-functional theory. The canonical density matrix perturbation theory can be used to calculate temperature-dependent response properties from the coupled perturbed self-consistent field equations as in density-functional perturbation theory. The method is well suited to take advantage of sparse matrix algebra to achieve linear scaling complexity in the computational cost as a function of system size for sufficiently large nonmetallic materials and metals at high temperatures. PMID:26764847

  16. Convergent synthesis of 6-substituted phenanthridines via anionic ring closure

    DEFF Research Database (Denmark)

    Lysén, M.; Kristensen, Jesper Langgaard; Vedsø, P.;

    2002-01-01

    Chemical equation presented The addition of organometallic derivatives to the cyano group of 2-(2-fluorophenyl)benzonitrile followed by intramolecular nucleophilic substitution produces 6-substituted phenanthridines. Alkyllithiums, aryllithiums, and sterically nondemanding lithium amides reacted ...

  17. Design of a thermophotovoltaic battery substitute

    Science.gov (United States)

    Doyle, Edward F.; Becker, Frederick E.; Shukla, Kailash C.; Fraas, Lewis M.

    1999-03-01

    Many military platforms that currently use the BA-5590 primary battery or the BB-390A/U rechargeable battery are limited in performance by low storage capacity and long recharge times. Thermo Power Corporation, with team members JX Crystals and Essential Research Inc. is developing an advanced thermophotovoltaic (TPV) battery substitute that will provide higher storage capacity, lower weight, and instantaneous recharging (by refueling). The TPV battery substitute incorporates several advanced design features including: an evacuated and sealed enclosure for the emitter and PV cells to minimize unwanted convection heat transfer from the emitter to PV cells; selective tungsten emitter with a well matched gallium antimonide PV cell receiver; optical filter to recycle nonconvertible radiant energy; and a silicon carbide thermal recuperator to recover thermal energy from exhaust gases.

  18. Generic substitution: issues for problematic drugs.

    Science.gov (United States)

    Henderson, J D; Esham, R H

    2001-01-01

    The methodology and criteria for bioequivalence testing have been firmly established by the Food and Drug Administration (FDA). For certain drugs with a narrow therapeutic index (e.g., digoxin, levothyroxine, warfarin), generic substitution may not be advisable or even allowable, depending on the substitution laws of individual states. Digoxin and levothyroxine tablets are examples of drugs for which no New Drug Applications (NDAs) currently exist. However, commercially available generic products for both of these drugs have not been determined by the FDA to be therapeutically equivalent to the innovator products. Generic versions of warfarin have been approved by the FDA as being therapeutically equivalent to the innovator products, as have generic versions of the rescue inhaler albuterol. Yet, misinformation and myths persist regarding the adequacy and proven reliability of the FDA's determination of bioequivalence for these products.

  19. Cohomology in one-dimensional substitution tiling spaces

    OpenAIRE

    Barge, Marcy; Diamond, Beverly

    2007-01-01

    Anderson and Putnam showed that the cohomology of a substitution tiling space may be computed by collaring tiles to obtain a substitution which ``forces its border.'' One can then represent the tiling space as an inverse limit of an inflation and substitution map on a cellular complex formed from the collared tiles; the cohomology of the tiling space is computed as the direct limit of the homomorphism induced by inflation and substitution on the cohomology of the complex. For one-dimensional ...

  20. The Use of Dermal Substitutes in Burn Surgery: Acute Phase

    OpenAIRE

    Shahrokhi, Shahriar; Anna, Arno; Marc G. Jeschke

    2014-01-01

    Dermal substitutes are increasingly becoming an essential part of the burn care strategy. During the acute phase of burn treatment, dermal substitutes improve functional and cosmetic results long-term and thus increase quality of life. In the chronic wound setting, dermal substitutes are used to reconstruct and improve burn scars and other defects. Despite some successes in the use of dermal substitutes there are more needs and requirements to further improve outcomes and hence further resear...

  1. Interfuel Substitution in the United States

    OpenAIRE

    Serletis, Apostolos; Timilsina, Govinda R.; Vasetsky, Olexandr

    2010-01-01

    In this paper, we use the locally flexible translog functional form to investigate the demand for energy and interfuel substitution in the United States and to provide a comparison of our results with most of the existing empirical energy demand literature. Motivated by the widespread practice of ignoring theoretical regularity, we follow Barnett's (2002) suggestions and estimate the model subject to theoretical regularity, using methods developed by Diewert and Wales (1987) and Ryan and Wale...

  2. Application of Substitutional Model in Oxide Systems

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The application of substitutional model in oxide systems, in comparison with that of sublattice model, is discussed.The results show that in the case of crystalline phases and liquid phases without molecular-like associates or theshortage of element in sublattice, these two models get consistent in the description of the formalism of Gibbs freeenergies of phases and obtain the same result of phase diagram calculation when the valence of the cations keep thesame.

  3. Spin Reorientation in Substituted Barium Ferrite

    OpenAIRE

    Greneche, J.; Randrianantoandro, N.; Y. Labaye; Boust, F.; Flavin, E.; Pascard, H.

    1997-01-01

    The structural transformation of substituted hexagonal ferrite powders BaFe10CoTiO19 prepared by mechanical milling, was investigated as a function of grinding time by means of Mössbauer spectrometry and static magnetic measurements. A spin reorientation is clearly evidenced from the temperature dependence of the hyperfine parameters and of the initial magnetic permeability on the powder mechanically treated for 23h.

  4. Biological activities of substituted trichostatic acid derivatives

    Indian Academy of Sciences (India)

    Cédric Charrier; Joëlle Roche; Jean-Pierre Gesson; Philippe Bertrand

    2009-07-01

    New substituted trichostatic acid derivatives have been synthesized and evaluated for their biological activities towards the H661 non-small lung cancer cell line. These syntheses were achieved by alkylation of propiophenones to introduce the side chain with a terminal precursor of hydroxamic acid and aminobenzamide derivatives. The first fluorinated derivatives of trichostatic acid are described, such as 6-fluoro trichostatin A, with antiproliferative activities in the micromolar range and with histone deacetylase inhibitory activity.

  5. Sugar substitutes: Health controversy over perceived benefits

    OpenAIRE

    Tandel, Kirtida R.

    2011-01-01

    Sugar is an inseparable part of the food we consume. But too much sugar is not ideal for our teeth and waistline. There have been some controversial suggestions that excessive sugar may play an important role in certain degenerative diseases. So artificial sweeteners or artificially sweetened products continue to attract consumers. A sugar substitute (artificial sweetener) is a food additive that duplicates the effect of sugar in taste, but usually has less food energy. Besides its benefits, ...

  6. On the Practical Limits to Substitution

    OpenAIRE

    Ayres, R U

    2005-01-01

    This paper began as a commentary on a draft paper by Pezzey and Toman on the economics of sustainability (Pezzey and Toman 2002), although it has evolved considerably since then. The authors characterize economists' views on the potential for substitution of man-made capital for natural capital as a continuum between the strongly neoclassical positions of Solow and Weitzman, at one extreme and the "entropy pessimists", notably Georgescu-Roegen and Daly, at the other. Solow has argued that man...

  7. Matrix product operators, matrix product states, and ab initio density matrix renormalization group algorithms.

    Science.gov (United States)

    Chan, Garnet Kin-Lic; Keselman, Anna; Nakatani, Naoki; Li, Zhendong; White, Steven R

    2016-07-01

    Current descriptions of the ab initio density matrix renormalization group (DMRG) algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational parallelism. The connections and correspondences described here serve to link the future developments with the past and are important in the efficient implementation of continuing advances in ab initio DMRG and related algorithms. PMID:27394094

  8. Matrix product operators, matrix product states, and ab initio density matrix renormalization group algorithms

    Science.gov (United States)

    Chan, Garnet Kin-Lic; Keselman, Anna; Nakatani, Naoki; Li, Zhendong; White, Steven R.

    2016-07-01

    Current descriptions of the ab initio density matrix renormalization group (DMRG) algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational parallelism. The connections and correspondences described here serve to link the future developments with the past and are important in the efficient implementation of continuing advances in ab initio DMRG and related algorithms.

  9. Matrix product operators, matrix product states, and ab initio density matrix renormalization group algorithms.

    Science.gov (United States)

    Chan, Garnet Kin-Lic; Keselman, Anna; Nakatani, Naoki; Li, Zhendong; White, Steven R

    2016-07-01

    Current descriptions of the ab initio density matrix renormalization group (DMRG) algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational parallelism. The connections and correspondences described here serve to link the future developments with the past and are important in the efficient implementation of continuing advances in ab initio DMRG and related algorithms.

  10. GoM Diet Matrix

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set was taken from CRD 08-18 at the NEFSC. Specifically, the Gulf of Maine diet matrix was developed for the EMAX exercise described in that center...

  11. Matrix Quantum Mechanics from Qubits

    CERN Document Server

    Hartnoll, Sean A; Mazenc, Edward A

    2016-01-01

    We introduce a transverse field Ising model with order N^2 spins interacting via a nonlocal quartic interaction. The model has an O(N,Z), hyperoctahedral, symmetry. We show that the large N partition function admits a saddle point in which the symmetry is enhanced to O(N). We further demonstrate that this `matrix saddle' correctly computes large N observables at weak and strong coupling. The matrix saddle undergoes a continuous quantum phase transition at intermediate couplings. At the transition the matrix eigenvalue distribution becomes disconnected. The critical excitations are described by large N matrix quantum mechanics. At the critical point, the low energy excitations are waves propagating in an emergent 1+1 dimensional spacetime.

  12. Interfuel substitution in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Serletis, Apostolos; Vasetsky, Olexandr [Department of Economics, University of Calgary, Calgary, Alberta (Canada); Timilsina, Govinda R. [Development Research Group, The World Bank, 1818 H Street N.W., Washington, DC 20433 (United States)

    2010-05-15

    In this paper, we use the locally flexible translog functional form to investigate the demand for energy and interfuel substitution in the United States and to provide a comparison of our results with most of the existing empirical energy demand literature. Motivated by the widespread practice of ignoring theoretical regularity, we follow Barnett's (2002) suggestions and estimate the model subject to theoretical regularity, using methods developed by Diewert and Wales (1987) and Ryan and Wales (2000), in an attempt to produce inference consistent with neoclassical microeconomic theory. Moreover, we use the most recent data, published by the U.S. Energy Information Administration (EIA), and in addition to investigating interfuel substitution possibilities in total U.S. energy demand, we follow Serletis et al. (2009) and also examine interfuel substitution possibilities in energy demand by sector. Moreover, we test for weak separability, with the objective of discovering the structure of the functional form in total energy demand as well as energy demand by sector. (author)

  13. 19 CFR 122.86 - Substitution of aircraft.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Substitution of aircraft. 122.86 Section 122.86... Substitution of aircraft. (a) Application. The residue cargo procedure applies when an airline must substitute aircraft to reach a destination due to weather conditions or operational factors which prevent an...

  14. 40 CFR 721.575 - Substituted alkyl halide.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted alkyl halide. 721.575... Substances § 721.575 Substituted alkyl halide. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted alkyl halide (PMN P-83-1222)...

  15. 40 CFR 721.2025 - Substituted phenylimino carbamate derivative.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted phenylimino carbamate... Specific Chemical Substances § 721.2025 Substituted phenylimino carbamate derivative. (a) Chemical... as a substituted phenylimino carbamate derivative (PMN P-91-487) is subject to reporting under...

  16. Competition Derived from Innovation as a Substitution Threat

    DEFF Research Database (Denmark)

    Howells, John

    2003-01-01

    This paper is a review of the role of innovation as substitution threat. The interesting strategy for those facing what in retrospect proves to be full substitution is the strategy of 'switch' to the substituting technology. the context-dependent uncedrtainty involved in the switch decision is ex...

  17. 40 CFR 721.843 - Substituted phenylazophenylazo phenol (generic).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted phenylazophenylazo phenol... Specific Chemical Substances § 721.843 Substituted phenylazophenylazo phenol (generic). (a) Chemical... as substituted phenylazophenylazo, phenol (PMN P-00-0420) is subject to reporting under this...

  18. 40 CFR 721.640 - Amine substituted metal salts.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Amine substituted metal salts. 721.640... Substances § 721.640 Amine substituted metal salts. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as amine substituted metal...

  19. 40 CFR 721.320 - Acrylamide-substituted epoxy.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Acrylamide-substituted epoxy. 721.320... Substances § 721.320 Acrylamide-substituted epoxy. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as acrylamide-substituted epoxy (PMN...

  20. 76 FR 8666 - Substitution in Case of Death of Claimant

    Science.gov (United States)

    2011-02-15

    ... scope of substitution and would be consistent with the language of the Act. Section 3.1010(g)(1) would... other members of a joint class, if any. Second, paragraph (g)(2) would specify that past-due benefits...) through (5) may substitute for the deceased substitute but only if the person requesting the...

  1. Substitute Addiction: A Concern for Researchers and Practitioners

    Science.gov (United States)

    Sussman, Steve; Black, David S.

    2008-01-01

    An understanding of the role of substitute addictions remains unclear. This article examines the range and possible reward functions of substitute addictions. We suggest that prevention education and treatment need to take into account substitute addictions as an influential aspect of recovery. Research is needed to better understand the…

  2. Film review: The Matrix cult

    OpenAIRE

    Tumanov, Vladimir

    2003-01-01

    Much of the semiotic discussion around the deeper structures of "The Matrix" has tended to center around positive ethical and philosophical systems. Thus, numerous critics have pointed out the Christian subtext in the film with Neo as Christ and Morpheus as John the Baptist (James L. Ford: 8). The Garden of Eden story has been superimposed on "The Matrix" as well with the implication that just as Adam's and Eve's awakening to knowledge makes Christianity possible, so too, Neo's awakening will...

  3. Hyaluronan-Dependent Pericellular Matrix

    OpenAIRE

    Evanko, Stephen P.; Tammi, Markku I; Tammi, Raija H.; Wight, Thomas N.

    2007-01-01

    Hyaluronan is a multifunctional glycosaminoglycan that forms the structural basis of the pericellular matrix. Hyaluronan is extruded directly through the plasma membrane by one of three hyaluronan synthases and anchored to the cell surface by the synthase or cell surface receptors such as CD44 or RHAMM. Aggregating proteoglycans and other hyaluronan-binding proteins, contribute to the material and biological properties of the matrix and regulate cell and tissue function. The pericellular matr...

  4. Flows for rectangular matrix models

    OpenAIRE

    Lafrance, Rene; Myers, Robert C.

    1993-01-01

    Several new results on the multicritical behavior of rectangular matrix models are presented. We calculate the free energy in the saddle point approximation, and show that at the triple-scaling point, the result is the same as that derived from the recursion formulae. In the triple-scaling limit, we obtain the string equation and a flow equation for arbitrary multicritical points. Parametric solutions are also examined for the limit of almost-square matrix models. This limit is shown to provi...

  5. Matrix analysis of electrical machinery

    CERN Document Server

    Hancock, N N

    2013-01-01

    Matrix Analysis of Electrical Machinery, Second Edition is a 14-chapter edition that covers the systematic analysis of electrical machinery performance. This edition discusses the principles of various mathematical operations and their application to electrical machinery performance calculations. The introductory chapters deal with the matrix representation of algebraic equations and their application to static electrical networks. The following chapters describe the fundamentals of different transformers and rotating machines and present torque analysis in terms of the currents based on the p

  6. Staggered chiral random matrix theory

    International Nuclear Information System (INIS)

    We present a random matrix theory for the staggered lattice QCD Dirac operator. The staggered random matrix theory is equivalent to the zero-momentum limit of the staggered chiral Lagrangian and includes all taste breaking terms at their leading order. This is an extension of previous work which only included some of the taste breaking terms. We will also present some results for the taste breaking contributions to the partition function and the Dirac eigenvalues.

  7. [Substitution in psychogeriatrics. A comparative study in nursing homes and substitution projects in Drenthe].

    Science.gov (United States)

    Schreurs, M

    1995-02-01

    Due to a strong increase of the ageing population in the Netherlands there is a growing need for care for psychogeriatric patients. The shortage of beds in psychogeriatric nursing homes has led to the development of substitute care in residential homes for the elderly and in community centers. If substitution is realized in these substitute care projects in the sense that alternative services are delivered for patients who would otherwise have been admitted to nursing homes, the level of impairment and disruptive behaviour should be of the same level in nursing homes and substitute care projects. Groups of patients of three nursing homes, three day-treatment facilities, eight day-care-projects in residential homes for the elderly and seven centers for day-care in the community were compared. Sociodemographic characteristics, behaviour and care-patterns of all 670 patients who were in care on the first of October of 1992 in these services were investigated. An assessment-scale for elderly patients, based on the Stockton Geriatric Rating Scale, was used to investigate behaviour. Substitute care appears to be possible for a limited and specific group of patients. Substitution for the severely disturbed patients (over 40% of the nursing home patients) does not seem to be possible. Due to the development of substitute care for psychogeriatric patients in residential homes for the elderly and centers for day-care in the community, services seem to develop towards more specific and specialized care. We recommend the foundation of a psychogeriatric case register, which allows the study of the transfer of patients across facilities.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. A new strategy for the decellularisation of large equine tendons as biocompatible tendon substitutes.

    Science.gov (United States)

    Bottagisio, M; Pellegata, A F; Boschetti, F; Ferroni, M; Moretti, M; Lovati, A B

    2016-01-01

    Tendon ruptures and/or large losses remain to be a great clinical challenge and often require full replacement of the damaged tissue. The use of auto- and allografts or engineered scaffolds is an established approach to restore severe tendon injuries. However, these grafts are commonly related to scarce biocompatibility, site morbidity, chronic inflammation and poor biomechanical properties. Recently, the decellularisation techniques of allo- or xenografts using specific detergents have been studied and have been found to generate biocompatible substitutes that resemble the native tissue. This study aims to identify a novel decellularisation protocol for large equine tendons that would produce an extracellular matrix scaffold suitable for the regeneration of injured tendons in humans. Specifically, equine tendons were treated either with tri (n-butyl) phosphate alone, or associated to multiple concentrations of peracetic acid (1, 3 and 5 %), which has never before been tested in vitro.Samples were then analysed by histology and with biochemical, biomechanical, and cytotoxicity tests. The best decellularisation protocol, resulting from these examinations, was selected and the chosen scaffold was re-seeded with murine fibroblasts. Resulting grafts were tested for cell viability, histologic analysis, DNA and collagen content. The results identified 1 % tri (n-butyl) phosphate combined with 3 % peracetic acid as the most suitable decellularised matrix in terms of biochemical and biomechanical properties. Moreover, the non-cytotoxic nature of the decellularised matrix allowed for good fibroblast reseeding, thus demonstrating a biocompatible matrix that will be suitable for tendon tissue engineering and hopefully as substitutes in severe tendon damages. PMID:27386840

  9. Matrix measure based dissipativity analysis for inertial delayed uncertain neural networks.

    Science.gov (United States)

    Tu, Zhengwen; Cao, Jinde; Hayat, Tasawar

    2016-03-01

    The present paper is devoted to investigating the global dissipativity for inertial neural networks with time-varying delays and parameter uncertainties. By virtue of a suitable substitution, the original system is transformed to the first order differential system. By means of matrix measure, generalized Halanay inequality, and matrix-norm inequality, several sufficient criteria for the global dissipativity of the addressed neural networks are proposed. Meanwhile, the specific estimations of positive invariant sets and globally attractive sets are obtained. Finally, two examples are provided to validate our theoretical results. PMID:26708738

  10. The matrix representation for the mathematic structure of Shannon's information measures

    Institute of Scientific and Technical Information of China (English)

    YUAN Yan-hua

    2007-01-01

    Shannon's information measure is a crucial concept in Information Theory. And the research, for the mathematics structure of Shannon's information measure, is to recognize the essence of information measure.The linear relation between Shannon's information measures and some signed measure space by using the formal symbols substitution rule is discussed. Furthermore, the coefficient matrix recurrent formula of the linear relation is obtained. Then the coefficient matrix is proved to be invertible via mathematical induction. This shows that the linear relation is one-to-one, and according to this, it can be concluded that a compact space can be generated from Shannon's information measures.

  11. Matrix measure based dissipativity analysis for inertial delayed uncertain neural networks.

    Science.gov (United States)

    Tu, Zhengwen; Cao, Jinde; Hayat, Tasawar

    2016-03-01

    The present paper is devoted to investigating the global dissipativity for inertial neural networks with time-varying delays and parameter uncertainties. By virtue of a suitable substitution, the original system is transformed to the first order differential system. By means of matrix measure, generalized Halanay inequality, and matrix-norm inequality, several sufficient criteria for the global dissipativity of the addressed neural networks are proposed. Meanwhile, the specific estimations of positive invariant sets and globally attractive sets are obtained. Finally, two examples are provided to validate our theoretical results.

  12. M-theoretic matrix models

    CERN Document Server

    Grassi, Alba

    2014-01-01

    Some matrix models admit, on top of the usual 't Hooft expansion, an M-theory-like expansion, i.e. an expansion at large N but where the rest of the parameters are fixed, instead of scaling with N. These models, which we call M-theoretic matrix models, appear in the localization of Chern-Simons-matter theories, and also in two-dimensional statistical physics. Generically, their partition function receives non-perturbative corrections which are not captured by the 't Hooft expansion. In this paper, we discuss general aspects of these type of matrix integrals and we analyze in detail two different examples. The first one is the matrix model computing the partition function of N=4 supersymmetric Yang-Mills theory in three dimensions with one adjoint hypermultiplet and N_f fundamentals, which has a conjectured M-theory dual, and which we call the N_f matrix model. The second one, which we call the polymer matrix model, computes form factors of the 2d Ising model and is related to the physics of 2d polymers. In bo...

  13. SVD row or column symmetric matrix

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A new architecture for row or column symmetric matrix called extended matrix is defined, and a precise correspondence of the singular values and singular vectors between the extended matrix and its original (namely, the mother matrix) is derived. As an illustration of potential, we show that, for a class of extended matrices, the singular value decomposition using the mother matrix rather than the extended matrix per se can save the CPU time and memory without loss of numerical precision.

  14. Analysis of innovative matrix systems for continuous fiber reinforced plastics in RTM process

    OpenAIRE

    Bosch Herrero, Mariona

    2012-01-01

    The use of lightweight and high-performance materials is nowadays one of the main challenge for the global automotive industry. Companies are forced to look for new ways to design and manufacture a commercially viable lightweight vehicle in order to meet stringent carbon emissions targets and offer highly fuel efficient vehicles to the consumer while maintaining structural performance. The use of polymer matrix composites in substitution of the present metal components remains a top priority....

  15. Dicty_cDB: Contig-U03473-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available rand = Plus / Minus Query: 109 aaanaaacgtganttattcgcaaanaaaa 137 ||||||||||||||||...||||||||||||| Sbjct: 60 aaanaaacgtganttattcgcaaanaaaa 32 Lambda K H 1.37 0.711 1.31 Matrix: blastn matrix:1

  16. Calculating the GONG Leakage Matrix

    Science.gov (United States)

    Hill, F.; Howe, R.

    Since spherical harmonics do not form a complete orthonormal basis set over a portion of a sphere, helioseismic spectra computed for a specific target mode with degree ellt and azimuthal degree mt also contain modes with nearby ell'' and m''. These spatial leaks greatly increase the complexity of the observed spectrum, complicating the spectral fitting and degrading the resulting mode parameter estimates. This is particularly true where the target mode and the leaks have similar frequencies. Some strategies for fitting helioseismic spectra explicitly include the leakage matrix which estimates the relative strength of a mode (ell'' and m'') in the spectrum at (ellt,mt). Since the fitting methods assume that the matrix is correct and apply it as a constraint, an inaccurate matrix introduces systematic errors in the estimated mode parameters. It is thus important to have as accurate a matrix as possible. Here we report on the calculation of the leakage matrix for the GONG observations. The matrix elements are essentially the integrals (over the observed portion of the solar surface) of the crossproducts of the two spherical harmonics. However, several effects have been included to increase the accuracy of the matrix. These include the projection factor of the observable (velocity, intensity, modulation), the spatial apodization applied to the data, the finite rectangular pixel dimensions of the observations, and possible errors in the estimated image geometry. Other factors to be incorporated are the observed MTF, the merging of the GONG images, and the horizontal components of the oscillatory velocity field. We will compare the latest calculation with the observed spectrum and assess the relative importance of the input factors. We will also compare the leakage matrices for velocity and intensity to estimate their contribution to the large apparent differences in the helioseismic spectra obtained from these observables.

  17. Currency Substitution and Inflation in Peru Currency Substitution and Inflation in Peru

    Directory of Open Access Journals (Sweden)

    Liliana Rojas-Suarez

    1992-03-01

    Full Text Available This paper shows that there is a long-run relationship between the expected rate of depreciation in the black-market-exchange rate and the ratio of domestic to foreign money in Peru: that is, the hypothesis of currency substitution can explain the behavior of real holdings of money in Peru. The paper also shows that, while, the importance of currency substitution as a transmission mechanism through which domestic policies affected the dynamics of inflation was relatively small during a period of high but relatively stable inflation (January 1978-85, it became an important factor in the inflation process during the recent hyperinflation episode. Currency Substitution and Inflation in Peru

  18. Derivation of an amino acid similarity matrix for peptide:MHC binding and its application as a Bayesian prior

    Directory of Open Access Journals (Sweden)

    Sette Alessandro

    2009-11-01

    Full Text Available Abstract Background Experts in peptide:MHC binding studies are often able to estimate the impact of a single residue substitution based on a heuristic understanding of amino acid similarity in an experimental context. Our aim is to quantify this measure of similarity to improve peptide:MHC binding prediction methods. This should help compensate for holes and bias in the sequence space coverage of existing peptide binding datasets. Results Here, a novel amino acid similarity matrix (PMBEC is directly derived from the binding affinity data of combinatorial peptide mixtures. Like BLOSUM62, this matrix captures well-known physicochemical properties of amino acid residues. However, PMBEC differs markedly from existing matrices in cases where residue substitution involves a reversal of electrostatic charge. To demonstrate its usefulness, we have developed a new peptide:MHC class I binding prediction method, using the matrix as a Bayesian prior. We show that the new method can compensate for missing information on specific residues in the training data. We also carried out a large-scale benchmark, and its results indicate that prediction performance of the new method is comparable to that of the best neural network based approaches for peptide:MHC class I binding. Conclusion A novel amino acid similarity matrix has been derived for peptide:MHC binding interactions. One prominent feature of the matrix is that it disfavors substitution of residues with opposite charges. Given that the matrix was derived from experimentally determined peptide:MHC binding affinity measurements, this feature is likely shared by all peptide:protein interactions. In addition, we have demonstrated the usefulness of the matrix as a Bayesian prior in an improved scoring-matrix based peptide:MHC class I prediction method. A software implementation of the method is available at: http://www.mhc-pathway.net/smmpmbec.

  19. A survey of matrix theory and matrix inequalities

    CERN Document Server

    Marcus, Marvin

    2010-01-01

    Written for advanced undergraduate students, this highly regarded book presents an enormous amount of information in a concise and accessible format. Beginning with the assumption that the reader has never seen a matrix before, the authors go on to provide a survey of a substantial part of the field, including many areas of modern research interest.Part One of the book covers not only the standard ideas of matrix theory, but ones, as the authors state, ""that reflect our own prejudices,"" among them Kronecker products, compound and induced matrices, quadratic relations, permanents, incidence

  20. The Astrobiology Matrix and the "Drake Matrix" in Education

    Science.gov (United States)

    Mizser, A.; Kereszturi, A.

    2003-01-01

    We organized astrobiology lectures in the Eotvos Lorand University of Sciences and the Polaris Observatory in 2002. We present here the "Drake matrix" for the comparison of the astrobiological potential of different bodies [1], and astrobiology matrix for the visualization of the interdisciplinary connections between different fields of astrobiology. Conclusion: In Hungary it is difficult to integrate astrobiology in the education system but the great advantage is that it can connect different scientific fields and improve the view of students. We would like to get in contact with persons and organizations who already have experience in the education of astrobiology.

  1. Matrix factorizations and elliptic fibrations

    Directory of Open Access Journals (Sweden)

    Harun Omer

    2016-09-01

    Full Text Available I use matrix factorizations to describe branes at simple singularities of elliptic fibrations. Each node of the corresponding Dynkin diagrams of the ADE-type singularities is associated with one indecomposable matrix factorization which can be deformed into one or more factorizations of lower rank. Branes with internal fluxes arise naturally as bound states of the indecomposable factorizations. Describing branes in such a way avoids the need to resolve singularities. This paper looks at gauge group breaking from E8 fibers down to SU(5 fibers due to the relevance of such fibrations for local F-theory GUT models. A purpose of this paper is to understand how the deformations of the singularity are understood in terms of its matrix factorizations. By systematically factorizing the elliptic fiber equation, this paper discusses geometries which are relevant for building semi-realistic local models. In the process it becomes evident that breaking patterns which are identical at the level of the Kodaira type of the fibers can be inequivalent at the level of matrix factorizations. Therefore the matrix factorization picture supplements information which the conventional less detailed descriptions lack.

  2. Octonionic matrix representation and electromagnetism

    Energy Technology Data Exchange (ETDEWEB)

    Chanyal, B. C. [Kumaun University, S. S. J. Campus, Almora (India)

    2014-12-15

    Keeping in mind the important role of octonion algebra, we have obtained the electromagnetic field equations of dyons with an octonionic 8 x 8 matrix representation. In this paper, we consider the eight - dimensional octonionic space as a combination of two (external and internal) four-dimensional spaces for the existence of magnetic monopoles (dyons) in a higher-dimensional formalism. As such, we describe the octonion wave equations in terms of eight components from the 8 x 8 matrix representation. The octonion forms of the generalized potential, fields and current source of dyons in terms of 8 x 8 matrix are discussed in a consistent manner. Thus, we have obtained the generalized Dirac-Maxwell equations of dyons from an 8x8 matrix representation of the octonion wave equations in a compact and consistent manner. The generalized Dirac-Maxwell equations are fully symmetric Maxwell equations and allow for the possibility of magnetic charges and currents, analogous to electric charges and currents. Accordingly, we have obtained the octonionic Dirac wave equations in an external field from the matrix representation of the octonion-valued potentials of dyons.

  3. Matrix factorizations and elliptic fibrations

    Science.gov (United States)

    Omer, Harun

    2016-09-01

    I use matrix factorizations to describe branes at simple singularities of elliptic fibrations. Each node of the corresponding Dynkin diagrams of the ADE-type singularities is associated with one indecomposable matrix factorization which can be deformed into one or more factorizations of lower rank. Branes with internal fluxes arise naturally as bound states of the indecomposable factorizations. Describing branes in such a way avoids the need to resolve singularities. This paper looks at gauge group breaking from E8 fibers down to SU (5) fibers due to the relevance of such fibrations for local F-theory GUT models. A purpose of this paper is to understand how the deformations of the singularity are understood in terms of its matrix factorizations. By systematically factorizing the elliptic fiber equation, this paper discusses geometries which are relevant for building semi-realistic local models. In the process it becomes evident that breaking patterns which are identical at the level of the Kodaira type of the fibers can be inequivalent at the level of matrix factorizations. Therefore the matrix factorization picture supplements information which the conventional less detailed descriptions lack.

  4. Annonaceae substitution rates: a codon model perspective

    Directory of Open Access Journals (Sweden)

    Lars Willem Chatrou

    2014-01-01

    Full Text Available The Annonaceae includes cultivated species of economic interest and represents an important source of information for better understanding the evolution of tropical rainforests. In phylogenetic analyses of DNA sequence data that are used to address evolutionary questions, it is imperative to use appropriate statistical models. Annonaceae are cases in point: Two sister clades, the subfamilies Annonoideae and Malmeoideae, contain the majority of Annonaceae species diversity. The Annonoideae generally show a greater degree of sequence divergence compared to the Malmeoideae, resulting in stark differences in branch lengths in phylogenetic trees. Uncertainty in how to interpret and analyse these differences has led to inconsistent results when estimating the ages of clades in Annonaceae using molecular dating techniques. We ask whether these differences may be attributed to inappropriate modelling assumptions in the phylogenetic analyses. Specifically, we test for (clade-specific differences in rates of non-synonymous and synonymous substitutions. A high ratio of nonsynonymous to synonymous substitutions may lead to similarity of DNA sequences due to convergence instead of common ancestry, and as a result confound phylogenetic analyses. We use a dataset of three chloroplast genes (rbcL, matK, ndhF for 129 species representative of the family. We find that differences in branch lengths between major clades are not attributable to different rates of non-synonymous and synonymous substitutions. The differences in evolutionary rate between the major clades of Annonaceae pose a challenge for current molecular dating techniques that should be seen as a warning for the interpretation of such results in other organisms.

  5. Generic substitution, financial interests, and imperfect agency.

    Science.gov (United States)

    Rischatsch, Maurus; Trottmann, Maria; Zweifel, Peter

    2013-06-01

    Policy makers around the world seek to encourage generic substitution. In this paper, the importance of prescribing physicians' imperfect agency is tested using the fact that some Swiss jurisdictions allow physicians to dispense drugs on their own account (physician dispensing, PD) while others disallow it. We estimate a model of physician drug choice with the help of drug claim data, finding a significant positive association between PD and the use of generics. While this points to imperfect agency, generics are prescribed more often to patients with high copayments or low incomes.

  6. [Generic and biosimilar drug substitution: a panacea?].

    Science.gov (United States)

    Daly, M J; Guignard, B; Nendaz, M

    2015-10-14

    Drugs are the third largest source of expenditure under Switzerland's compulsory basic health insurance. Generics, the price of which should be at least 30 per cent less than the cost of the original drugs, can potentially allow substantial savings. Their approval requires bioequivalence studies and their use is safe, although some factors may influence patients' and physicians' acceptance. The increased substitution of biosimilar drugs for more expensive biotech drugs should allow further cost savings. In an attempt to extend the monopoly granted by the original drug patent, some pharmaceutical companies implement "evergreening" strategies including small modifications of the original substance for which the clinical benefit is not always demonstrated.

  7. Pyrrolyl substituted allenylidene complexes of ruthenium

    OpenAIRE

    Winter, Rainer; Hartmann, Stephan; Sarkar, Biprajit; Lissner, Falk

    2004-01-01

    Pyrrolyl and indolyl substituted allenylidene complexes of ruthenium have been prepared from the trapping of cationic trans-[Cl(dppm)2Ru[double bond, length as m-dash]C[double bond, length as m-dash]C[double bond, length as m-dash]C[double bond, length as m-dash]CH2]+ with various pyrroles or N-methylindole. The reaction is rationalized as involving regioselective attack of the organometallic electrophile on the electron-rich heterocycle followed by proton migration to the terminal [double bo...

  8. QSAR Studies on 7-Substituted Fluoroquinolones

    Institute of Scientific and Technical Information of China (English)

    XU Ju-Li; GAO Shu-Lin; ZHANG Xiang-Fei; XIE Yi-Ping; HUANG Xiao-Yin; XIE Xiao-Guang

    2007-01-01

    The PM3 and B3LYP methods were employed to calculate the properties of 18 7-substituted fluoroquinolones.The correlation between biological activity (against gram-positive organisms or gram-negative organisms) and structural properties was obtained by using multiple linear regression (MLR) methods.The best model generated correlates the antibacterial activity with EHOMO and QF8 for gram-positive organisms,and EHOMO and dipole moment for gram-negative organisms,respectively.It suggests that the interaction mechanisms of fluoroquinolons with gram-positive and gram-negative organisms are different.

  9. Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts.

    Science.gov (United States)

    Renom-Carrasco, Marc; Gajewski, Piotr; Pignataro, Luca; de Vries, Johannes G; Piarulli, Umberto; Gennari, Cesare; Lefort, Laurent

    2016-07-01

    The use of an equivalent amount of an organic base leads to high enantiomeric excess in the asymmetric hydrogenation of N-benzylated 3-substituted pyridinium salts into the corresponding piperidines. Indeed, in the presence of Et3 N, a Rh-JosiPhos catalyst reduced a range of pyridinium salts with ee values up to 90 %. The role of the base was elucidated with a mechanistic study involving the isolation of the various reaction intermediates and isotopic labeling experiments. Additionally, this study provided some evidence for an enantiodetermining step involving a dihydropyridine intermediate. PMID:27140832

  10. Pharmaceutical regulation, mandatory substitution, and generic competition

    OpenAIRE

    Birg, Laura

    2015-01-01

    This paper studies the effect of two regulatory instruments - a price cap and a reference price system - a mandatory substitution rule, and the combination of both on generic competition in a Salop-type model with an off-patent brand-name drug and n differentiated generic versions. The price cap reduces only the brand-name price, the reference price system reduces the brand-name price and generic prices. Both regulatory instruments reduce the generic market share and the number of generic com...

  11. Constant-Elasticity-of-Substitution Simulation

    Science.gov (United States)

    Reiter, G.

    1986-01-01

    Program simulates constant elasticity-of-substitution (CES) production function. CES function used by economic analysts to examine production costs as well as uncertainties in production. User provides such input parameters as price of labor, price of capital, and dispersion levels. CES minimizes expected cost to produce capital-uncertainty pair. By varying capital-value input, one obtains series of capital-uncertainty pairs. Capital-uncertainty pairs then used to generate several cost curves. CES program menu driven and features specific print menu for examining selected output curves. Program written in BASIC for interactive execution and implemented on IBM PC-series computer.

  12. ARTIFICIAL TEAR SUBSTITUTES: WHICH ONE & WHEN?

    Directory of Open Access Journals (Sweden)

    Prashanth

    2013-06-01

    Full Text Available ABSTRACT: Dry eye is a multi-factorial disease; the therapy should improve the symptoms and signs of dry eye as well as address the underlying pathophysiology of the disease. Artificial tear substitutes have been used for treating dry eye syndromes for decades and succeeded in enhancing the comfort of patients. They are currently the main therapy for dry eye and likely to remain the mainstay treatment modality. However, the currently used artificial tears have obvious limitations and its usage has to be personalized based on the patient’s need. This article briefs you on silent features in usage of artificial tears.

  13. Parallel R-matrix computation

    International Nuclear Information System (INIS)

    For almost thirty years, sequential R-matrix computation has been used by atomic physics research groups, from around the world, to model collision phenomena involving the scattering of electrons or positrons with atomic or molecular targets. As considerable progress has been made in the understanding of fundamental scattering processes, new data, obtained from more complex calculations, is of current interest to experimentalists. Performing such calculations, however, places considerable demands on the computational resources to be provided by the target machine, in terms of both processor speed and memory requirement. Indeed, in some instances the computational requirements are so great that the proposed R-matrix calculations are intractable, even when utilising contemporary classic supercomputers. Historically, increases in the computational requirements of R-matrix computation were accommodated by porting the problem codes to a more powerful classic supercomputer. Although this approach has been successful in the past, it is no longer considered to be a satisfactory solution due to the limitations of current (and future) Von Neumann machines. As a consequence, there has been considerable interest in the high performance multicomputers, that have emerged over the last decade which appear to offer the computational resources required by contemporary R-matrix research. Unfortunately, developing codes for these machines is not as simple a task as it was to develop codes for successive classic supercomputers. The difficulty arises from the considerable differences in the computing models that exist between the two types of machine and results in the programming of multicomputers to be widely acknowledged as a difficult, time consuming and error-prone task. Nevertheless, unless parallel R-matrix computation is realised, important theoretical and experimental atomic physics research will continue to be hindered. This thesis describes work that was undertaken in

  14. Extracellular matrix in ovarian follicles.

    Science.gov (United States)

    Rodgers, R J; Irving-Rodgers, H F; van Wezel, I L

    2000-05-25

    A lot is known about the control of the development of ovarian follicles by growth factors and hormones, but less is known about the roles of extracellular matrix in the control of follicular growth and development. In this review we focus on the specialized extracellular matrix of the basal laminas that are present in ovarian follicles. These include the follicular basal lamina itself, the Call-Exner bodies of the membrana granulosa, the subendothelial and arteriole smooth muscle basal laminas in the theca, and the basal lamina-like material of the thecal matrix. We discuss the evidence that during follicle development the follicular basal lamina changes in composition, that many of its components are produced by the granulosa cells, and that the follicular basal laminas of different follicles have different ultrastructural appearances, linked to the shape of the aligning granulosa cells. All these studies suggest that the follicular basal lamina is extremely dynamic during follicular development. PMID:10963877

  15. Numerical methods in matrix computations

    CERN Document Server

    Björck, Åke

    2015-01-01

    Matrix algorithms are at the core of scientific computing and are indispensable tools in most applications in engineering. This book offers a comprehensive and up-to-date treatment of modern methods in matrix computation. It uses a unified approach to direct and iterative methods for linear systems, least squares and eigenvalue problems. A thorough analysis of the stability, accuracy, and complexity of the treated methods is given. Numerical Methods in Matrix Computations is suitable for use in courses on scientific computing and applied technical areas at advanced undergraduate and graduate level. A large bibliography is provided, which includes both historical and review papers as well as recent research papers. This makes the book useful also as a reference and guide to further study and research work. Åke Björck is a professor emeritus at the Department of Mathematics, Linköping University. He is a Fellow of the Society of Industrial and Applied Mathematics.

  16. Matrix model approach to cosmology

    Science.gov (United States)

    Chaney, A.; Lu, Lei; Stern, A.

    2016-03-01

    We perform a systematic search for rotationally invariant cosmological solutions to toy matrix models. These models correspond to the bosonic sector of Lorentzian Ishibashi, Kawai, Kitazawa and Tsuchiya (IKKT)-type matrix models in dimensions d less than ten, specifically d =3 and d =5 . After taking a continuum (or commutative) limit they yield d -1 dimensional Poisson manifolds. The manifolds have a Lorentzian induced metric which can be associated with closed, open, or static space-times. For d =3 , we obtain recursion relations from which it is possible to generate rotationally invariant matrix solutions which yield open universes in the continuum limit. Specific examples of matrix solutions have also been found which are associated with closed and static two-dimensional space-times in the continuum limit. The solutions provide for a resolution of cosmological singularities, at least within the context of the toy matrix models. The commutative limit reveals other desirable features, such as a solution describing a smooth transition from an initial inflation to a noninflationary era. Many of the d =3 solutions have analogues in higher dimensions. The case of d =5 , in particular, has the potential for yielding realistic four-dimensional cosmologies in the continuum limit. We find four-dimensional de Sitter d S4 or anti-de Sitter AdS4 solutions when a totally antisymmetric term is included in the matrix action. A nontrivial Poisson structure is attached to these manifolds which represents the lowest order effect of noncommutativity. For the case of AdS4 , we find one particular limit where the lowest order noncommutativity vanishes at the boundary, but not in the interior.

  17. Supersymmetry in random matrix theory

    International Nuclear Information System (INIS)

    I study the applications of supersymmetry in random matrix theory. I generalize the supersymmetry method and develop three new approaches to calculate eigenvalue correlation functions. These correlation functions are averages over ratios of characteristic polynomials. In the first part of this thesis, I derive a relation between integrals over anti-commuting variables (Grassmann variables) and differential operators with respect to commuting variables. With this relation I rederive Cauchy- like integral theorems. As a new application I trace the supermatrix Bessel function back to a product of two ordinary matrix Bessel functions. In the second part, I apply the generalized Hubbard-Stratonovich transformation to arbitrary rotation invariant ensembles of real symmetric and Hermitian self-dual matrices. This extends the approach for unitarily rotation invariant matrix ensembles. For the k-point correlation functions I derive supersymmetric integral expressions in a unifying way. I prove the equivalence between the generalized Hubbard-Stratonovich transformation and the superbosonization formula. Moreover, I develop an alternative mapping from ordinary space to superspace. After comparing the results of this approach with the other two supersymmetry methods, I obtain explicit functional expressions for the probability densities in superspace. If the probability density of the matrix ensemble factorizes, then the generating functions exhibit determinantal and Pfaffian structures. For some matrix ensembles this was already shown with help of other approaches. I show that these structures appear by a purely algebraic manipulation. In this new approach I use structures naturally appearing in superspace. I derive determinantal and Pfaffian structures for three types of integrals without actually mapping onto superspace. These three types of integrals are quite general and, thus, they are applicable to a broad class of matrix ensembles. (orig.)

  18. Supersymmetry in random matrix theory

    Energy Technology Data Exchange (ETDEWEB)

    Kieburg, Mario

    2010-05-04

    I study the applications of supersymmetry in random matrix theory. I generalize the supersymmetry method and develop three new approaches to calculate eigenvalue correlation functions. These correlation functions are averages over ratios of characteristic polynomials. In the first part of this thesis, I derive a relation between integrals over anti-commuting variables (Grassmann variables) and differential operators with respect to commuting variables. With this relation I rederive Cauchy- like integral theorems. As a new application I trace the supermatrix Bessel function back to a product of two ordinary matrix Bessel functions. In the second part, I apply the generalized Hubbard-Stratonovich transformation to arbitrary rotation invariant ensembles of real symmetric and Hermitian self-dual matrices. This extends the approach for unitarily rotation invariant matrix ensembles. For the k-point correlation functions I derive supersymmetric integral expressions in a unifying way. I prove the equivalence between the generalized Hubbard-Stratonovich transformation and the superbosonization formula. Moreover, I develop an alternative mapping from ordinary space to superspace. After comparing the results of this approach with the other two supersymmetry methods, I obtain explicit functional expressions for the probability densities in superspace. If the probability density of the matrix ensemble factorizes, then the generating functions exhibit determinantal and Pfaffian structures. For some matrix ensembles this was already shown with help of other approaches. I show that these structures appear by a purely algebraic manipulation. In this new approach I use structures naturally appearing in superspace. I derive determinantal and Pfaffian structures for three types of integrals without actually mapping onto superspace. These three types of integrals are quite general and, thus, they are applicable to a broad class of matrix ensembles. (orig.)

  19. Polychoric/Tetrachoric Matrix or Pearson Matrix? A methodological study

    Directory of Open Access Journals (Sweden)

    Dominguez Lara, Sergio Alexis

    2014-04-01

    Full Text Available The use of product-moment correlation of Pearson is common in most studies in factor analysis in psychology, but it is known that this statistic is only applicable when the variables related are in interval scale and normally distributed, and when are used in ordinal data may to produce a distorted correlation matrix . Thus is a suitable option using polychoric/tetrachoric matrices in item-level factor analysis when the items are in level measurement nominal or ordinal. The aim of this study was to show the differences in the KMO, Bartlett`s Test and Determinant of the Matrix, percentage of variance explained and factor loadings in depression trait scale of Depression Inventory Trait - State and the Neuroticism dimension of the short form of the Eysenck Personality Questionnaire -Revised, regarding the use of matrices polychoric/tetrachoric matrices and Pearson. These instruments was analyzed with different extraction methods (Maximum Likelihood, Minimum Rank Factor Analysis, Unweighted Least Squares and Principal Components, keeping constant the rotation method Promin were analyzed. Were observed differences regarding sample adequacy measures, as well as with respect to the explained variance and the factor loadings, for solutions having as polychoric/tetrachoric matrix. So it can be concluded that the polychoric / tetrachoric matrix give better results than Pearson matrices when it comes to item-level factor analysis using different methods.

  20. Venturini Method Based Matrix Converter

    Directory of Open Access Journals (Sweden)

    Derick Mathew

    2015-03-01

    Full Text Available Recently, matrix converter has received considerable interest as a viable alternative to the conventional ac-dc-ac converter. This direct ac-ac converter provides some attractive characteristics such as: four quadrant operation, absence of bulky dc-link electrolyte capacitors, clean input power characteristics. Due to the absence of dc link energy storage elements any disturbance in the input voltage will be immediately reflected to the output voltages. In this paper venturini method for matrix converter has been presented. Three phase sinusoidal symmetrical voltage or current can obtained .

  1. Matrix methods applied linear algebra

    CERN Document Server

    Bronson, Richard

    2008-01-01

    Matrix Methods: Applied Linear Algebra, 3e, as a textbook, provides a unique and comprehensive balance between the theory and computation of matrices. The application of matrices is not just for mathematicians. The use by other disciplines has grown dramatically over the years in response to the rapid changes in technology. Matrix methods is the essence of linear algebra and is what is used to help physical scientists; chemists, physicists, engineers, statisticians, and economists solve real world problems.* Applications like Markov chains, graph theory and Leontief Models are placed i

  2. Staggered weak matrix element miscellany

    International Nuclear Information System (INIS)

    I report on work, done with Rajan Gupta and Greg Kilcup, using staggered fermions to study weak matrix elements in quenched QCD. I give an update on the ΔI = 1/2 rule on matrix elements relevant for ε'. I show results of a study of the dependence of BK on non-leading terms in the chiral expansion. I present our results for BK from quenched calculation at β = 6.4 on 323 x 48 lattices, based on ensemble of 12 configurations. 15 refs., 5 figs

  3. Towards Google matrix of brain

    OpenAIRE

    Shepelyansky, D. L.; Zhirov, O. V.

    2010-01-01

    We apply the approach of the Google matrix, used in computer science and World Wide Web, to description of properties of neuronal networks. The Google matrix ${\\bf G}$ is constructed on the basis of neuronal network of a brain model discussed in PNAS {\\bf 105}, 3593 (2008). We show that the spectrum of eigenvalues of ${\\bf G}$ has a gapless structure with long living relaxation modes. The PageRank of the network becomes delocalized for certain values of the Google damping factor $\\alpha$. The...

  4. Towards Google matrix of brain

    International Nuclear Information System (INIS)

    We apply the approach of the Google matrix, used in computer science and World Wide Web, to description of properties of neuronal networks. The Google matrix G is constructed on the basis of neuronal network of a brain model discussed in PNAS 105 (2008) 3593. We show that the spectrum of eigenvalues of G has a gapless structure with long living relaxation modes. The PageRank of the network becomes delocalized for certain values of the Google damping factor α. The properties of other eigenstates are also analyzed. We discuss further parallels and similarities between the World Wide Web and neuronal networks.

  5. Towards Google matrix of brain

    Energy Technology Data Exchange (ETDEWEB)

    Shepelyansky, D.L., E-mail: dima@irsamc.ups-tlse.f [Laboratoire de Physique Theorique (IRSAMC), Universite de Toulouse, UPS, F-31062 Toulouse (France); LPT - IRSAMC, CNRS, F-31062 Toulouse (France); Zhirov, O.V. [Budker Institute of Nuclear Physics, 630090 Novosibirsk (Russian Federation)

    2010-07-12

    We apply the approach of the Google matrix, used in computer science and World Wide Web, to description of properties of neuronal networks. The Google matrix G is constructed on the basis of neuronal network of a brain model discussed in PNAS 105 (2008) 3593. We show that the spectrum of eigenvalues of G has a gapless structure with long living relaxation modes. The PageRank of the network becomes delocalized for certain values of the Google damping factor {alpha}. The properties of other eigenstates are also analyzed. We discuss further parallels and similarities between the World Wide Web and neuronal networks.

  6. Symmetries and Interactions in Matrix String Theory

    NARCIS (Netherlands)

    F.H. Hacquebord

    1999-01-01

    This PhD-thesis reviews matrix string theory and recent developments therein. The emphasis is put on symmetries, interactions and scattering processes in the matrix model. We start with an introduction to matrix string theory and a review of the orbifold model that flows out of matrix string theory

  7. Properties of the matrix A-XY

    NARCIS (Netherlands)

    Steerneman, A.G.M.; van Perlo -ten Kleij, Frederieke

    2005-01-01

    The main topic of this paper is the matrix V = A - XY*, where A is a nonsingular complex k x k matrix and X and Y are k x p complex matrices of full column rank. Because properties of the matrix V can be derived from those of the matrix Q = I - XY*, we will consider in particular the case where A =

  8. [Generic drugs and the rights of substitution].

    Science.gov (United States)

    Vallée, J P

    1999-03-13

    Compared with other countries with a similar socio-economic environment, generic drugs account for a very small proportion of pharmaceutical sales in France. The recently promulgated law on financing the national healthcare system states that drug dispensers have the right to substitute generic drugs for prescription drugs in accordance with the drug equivalence repertoire established by the national drug agency. How patients, pharmacists, physicians and industrial firms will react to this new situation is an open question as use of generic drugs is basically unknown in France. Prescribing physicians, members of the drug agency, pharmacists, health economists, and insurance company and pharmaceutical firm representatives participated in a round table discussion to clarify the ongoing debate on the effect of this new cultural situation which calls an end to the French "exception" in drug consumption. The concept of generics and their use in substitution for prescription drugs was discussed in light of the outlined economic objectives together with the advantages and disadvantages patients and physicians can expect. PMID:10209545

  9. JROTC as a Substitute for PE: Really?

    Science.gov (United States)

    Lounsbery, Monica A. F.; Holt, Kathryn A.; Monnat, Shannon A.; McKenzie, Thomas L.; Funk, Brian

    2014-01-01

    Purpose Even though physical education (PE) is an evidence-based strategy for providing and promoting physical activity, alternative programs such as Junior Reserve Officer Training Corps (JROTC) are commonly substituted for PE in many states. The purpose of this study was to compare student physical activity and lesson contexts during high school PE and JROTC sessions. Method SOFIT (System for Observing Fitness Instruction Time) was used to assess PE and JROTC sessions (N=38 each) in 4 high schools that provided both programs. Data were analyzed using t-tests, negative binomial regression, and logistic regression. Results Students engaged in significantly more moderate to vigorous physical activity during PE than JROTC sessions and they were significantly less sedentary. Significant differences between the two program types were also found among lesson contexts. Conclusions PE and JROTC provide substantially different content and contexts and students in them engage in substantially different amounts of moderate to vigorous physical activity. Students in JROTC, and perhaps other alternative programs, are less likely to accrue health-supporting physical activity and engage in fewer opportunities to be physically fit and motorically skilled. Policies and practices for providing substitutions for PE should be carefully examined. PMID:25141093

  10. Challenges in drug discovery for thiazolidinedione substitute

    Directory of Open Access Journals (Sweden)

    Jian-ping Ye

    2011-10-01

    Full Text Available Thiazolidinedione (TZD is a powerful insulin sensitizer in the treatment of type 2 diabetes. It acts as a ligand to the nuclear receptor PPARγ (peroxisome proliferator-activated receptor-gamma and induces transcription of PPARγ-responsive genes. TZD controls lipid synthesis and storage in adipose tissue, liver and many other tissues through PPARγ. Derivatives of TZD, such as rosiglitazone (Avandia and pioglitazone (Actos, are more powerful than metformin or berberine in insulin sensitization. Although they have common side effects such as weight gain and edema, these did not influence their clinical application in general. However, recent findings of risk for congestive heart failure and bladder cancer have significantly impaired their future in many countries. European countries have prohibited those drugs, and US will terminate application of rosiglitazone in clinics and hospitals. The multiple country actions may mark the end of TZD era. As a result, there is a strong demand for identification of TZD substitute in the treatment of type 2 diabetes. In this regard, literature about PPARγ ligands and potential TZD substitute are reviewed in this article. Histone deacetylase (HDAC inhibitor is emphasized as a new class of insulin sensitizer here. Regulators of SIRT1, CREB, NO, p38, ERK and Cdk5 are discussed in the activation of PPARγ.

  11. Sugar substitutes: Health controversy over perceived benefits

    Directory of Open Access Journals (Sweden)

    Kirtida R Tandel

    2011-01-01

    Full Text Available Sugar is an inseparable part of the food we consume. But too much sugar is not ideal for our teeth and waistline. There have been some controversial suggestions that excessive sugar may play an important role in certain degenerative diseases. So artificial sweeteners or artificially sweetened products continue to attract consumers. A sugar substitute (artificial sweetener is a food additive that duplicates the effect of sugar in taste, but usually has less food energy. Besides its benefits, animal studies have convincingly proven that artificial sweeteners cause weight gain, brain tumors, bladder cancer and many other health hazards. Some kind of health related side effects including carcinogenicity are also noted in humans. A large number of studies have been carried out on these substances with conclusions ranging from "safe under all conditions" to "unsafe at any dose". Scientists are divided in their views on the issue of artificial sweetener safety. In scientific as well as in lay publications, supporting studies are often widely referenced while the opposing results are de-emphasized or dismissed. So this review aims to explore the health controversy over perceived benefits of sugar substitutes.

  12. Substitution among exhaustible resources and intergenerational equity

    Energy Technology Data Exchange (ETDEWEB)

    Hartwick, J.M.

    1978-06-01

    Hartwick (American Econ. Rev., 66 (Dec. 1977)) showed that implicit in R.M. Solow's model of intergenerational equity and exhaustible resources (Rev. Econ. Studies (Symposium, 1974) 29-46) was the savings-investment rule: society should invest in reproducible capital precisely the current returns from the use of flows of exhaustible resources in order to maintain per capita consumption constant. Population was assumed to remain constant. Solow and Hartwick assumed that there was only one exhaustible resource. Beckmann (American Econ. Rev., 65, 695-99 (Sept 1975)) investigated optimal growth in models with many exhaustible resources. In this paper the case of many exhaustible resources is considered and results are derived on substitution among resources and on the nature of paths of development. One of Beckmann's results on substitution is analyzed. The approach is first to analyze efficient paths under the assumption of general savings functions and then to analyze efficient paths under the assumption of the special savings function referred to above. Results indicate the Solow's existence theorem remains valid for the case of many exhaustible resources and some light is shed on the existence of paths for production functions not of the Cobb-Douglas form. 12 references.

  13. Coal to gas substitution using coal?!

    Science.gov (United States)

    Kempka, Thomas; Schlüter, Ralph

    2010-05-01

    Substitution of carbon-intensive coal with less carbon-intensive natural gas for energy production is discussed as one main pillar targeting reduction of antrophogenic greenhouse gas emissions by means of climate change mitigation. Other pillars are energy efficiency, renewable energies, carbon capture and storage as well as further development of nuclear energy. Taking into account innovative clean coal technologies such as UCG-CCS (underground coal gasification with carbon capture and storage), in which coal deposits are developed using directional drilling technologies and subsequently converted into a synthesis gas of high calorific value, the coupled conceptual approach can provide a synergetic technology for coal utilization and mitigation of carbon emissions. This study aims at the evaluation of UCǴ s carbon mitigation potentials and the review of the economical boundary conditions. The analytical models applied within this study are based on data available from world-wide UCG projects and extensive laboratory studies. In summary, scenarios considering costs and carbon storage potentials are economically feasible and thus competitive with less carbon-intensive energy generation technologies such as natural gas. Thus, coal to gas substitution can be one of the coal based options.

  14. Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

    Directory of Open Access Journals (Sweden)

    Jingkang Shen

    2006-12-01

    Full Text Available A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1 in an in vitro biological assay.

  15. Allylhydridopolycarbosilane (AHPCS) as matrix resin for C/SiC ceramic matrix composites

    Energy Technology Data Exchange (ETDEWEB)

    Sreeja, R. [Ceramic Matrix Products Division, Propellants and Special Chemicals Group, PCM Entity, Vikram Sarabhai Space Center, Thiruvananthapuram 695022 (India); Swaminathan, B., E-mail: swami1423@gmail.co [Ceramic Matrix Products Division, Propellants and Special Chemicals Group, PCM Entity, Vikram Sarabhai Space Center, Thiruvananthapuram 695022 (India); Painuly, Anil; Sebastian, T.V.; Packirisamy, S. [Ceramic Matrix Products Division, Propellants and Special Chemicals Group, PCM Entity, Vikram Sarabhai Space Center, Thiruvananthapuram 695022 (India)

    2010-04-15

    In present study, partially allyl-substituted hydridopolycarbosilane (5 mol% allyl) [AHPCS] has been characterized by spectral techniques and thermal analysis. The DSC studies show that, the polymer is self-cross-linking at lower temperatures without any incorporation of cross-linking agents. The spectral and thermal characterizations carried out at different processing stages indicate the possibility of extensive structural rearrangement accompanied by the loss of hydrogen and other reactions of C and Si containing species resulting in the conversion of the branched chain segment into a 3D SiC network structure. AHPCS gave ceramic residue of 72% and 70% at 900 and 1500 deg. C respectively in argon atmosphere. XRD pattern of 1500 deg. C heat-treated AHPCS, indicates the formation of silicon carbide with the particle size of 3-4 nm. AHPCS was used as matrix resin for the preparation of C/SiC composite without any interfacial coating over the T-300 carbon fabric reinforcement. Flexural strength value of 74-86 MPa for C/SiC specimen with density of 1.7 g/cm{sup 3} was obtained after four infiltration and pyrolysis cycles.

  16. Sign Patterns That Allow the Given Matrix

    Institute of Scientific and Technical Information of China (English)

    邵燕灵; 孙良

    2003-01-01

    Let P be a property referring to a real matrix. For a sign pattern A, if there exists a real matrix B in the qualitative class of A such that B has property P, then we say A allows P. Three cases that A allows an M-matrix, an inverse M-matrix and a P0-matrix are considered. The complete characterizations are obtained.

  17. Rapid prototyped porous nickel–titanium scaffolds as bone substitutes

    Directory of Open Access Journals (Sweden)

    Waldemar Hoffmann

    2014-06-01

    Full Text Available While calcium phosphate–based ceramics are currently the most widely used materials in bone repair, they generally lack tensile strength for initial load bearing. Bulk titanium is the gold standard of metallic implant materials, but does not match the mechanical properties of the surrounding bone, potentially leading to problems of fixation and bone resorption. As an alternative, nickel–titanium alloys possess a unique combination of mechanical properties including a relatively low elastic modulus, pseudoelasticity, and high damping capacity, matching the properties of bone better than any other metallic material. With the ultimate goal of fabricating porous implants for spinal, orthopedic and dental applications, nickel–titanium substrates were fabricated by means of selective laser melting. The response of human mesenchymal stromal cells to the nickel–titanium substrates was compared to mesenchymal stromal cells cultured on clinically used titanium. Selective laser melted titanium as well as surface-treated nickel–titanium and titanium served as controls. Mesenchymal stromal cells had similar proliferation rates when cultured on selective laser melted nickel–titanium, clinically used titanium, or controls. Osteogenic differentiation was similar for mesenchymal stromal cells cultured on the selected materials, as indicated by similar gene expression levels of bone sialoprotein and osteocalcin. Mesenchymal stromal cells seeded and cultured on porous three-dimensional selective laser melted nickel–titanium scaffolds homogeneously colonized the scaffold, and following osteogenic induction, filled the scaffold’s pore volume with extracellular matrix. The combination of bone-related mechanical properties of selective laser melted nickel–titanium with its cytocompatibility and support of osteogenic differentiation of mesenchymal stromal cells highlights its potential as a superior bone substitute as compared to clinically used

  18. Rapid prototyped porous nickel-titanium scaffolds as bone substitutes.

    Science.gov (United States)

    Hoffmann, Waldemar; Bormann, Therese; Rossi, Antonella; Müller, Bert; Schumacher, Ralf; Martin, Ivan; de Wild, Michael; Wendt, David

    2014-01-01

    While calcium phosphate-based ceramics are currently the most widely used materials in bone repair, they generally lack tensile strength for initial load bearing. Bulk titanium is the gold standard of metallic implant materials, but does not match the mechanical properties of the surrounding bone, potentially leading to problems of fixation and bone resorption. As an alternative, nickel-titanium alloys possess a unique combination of mechanical properties including a relatively low elastic modulus, pseudoelasticity, and high damping capacity, matching the properties of bone better than any other metallic material. With the ultimate goal of fabricating porous implants for spinal, orthopedic and dental applications, nickel-titanium substrates were fabricated by means of selective laser melting. The response of human mesenchymal stromal cells to the nickel-titanium substrates was compared to mesenchymal stromal cells cultured on clinically used titanium. Selective laser melted titanium as well as surface-treated nickel-titanium and titanium served as controls. Mesenchymal stromal cells had similar proliferation rates when cultured on selective laser melted nickel-titanium, clinically used titanium, or controls. Osteogenic differentiation was similar for mesenchymal stromal cells cultured on the selected materials, as indicated by similar gene expression levels of bone sialoprotein and osteocalcin. Mesenchymal stromal cells seeded and cultured on porous three-dimensional selective laser melted nickel-titanium scaffolds homogeneously colonized the scaffold, and following osteogenic induction, filled the scaffold's pore volume with extracellular matrix. The combination of bone-related mechanical properties of selective laser melted nickel-titanium with its cytocompatibility and support of osteogenic differentiation of mesenchymal stromal cells highlights its potential as a superior bone substitute as compared to clinically used titanium.

  19. Regularization in Matrix Relevance Learning

    NARCIS (Netherlands)

    Schneider, Petra; Bunte, Kerstin; Stiekema, Han; Hammer, Barbara; Villmann, Thomas; Biehl, Michael

    2010-01-01

    A In this paper, we present a regularization technique to extend recently proposed matrix learning schemes in learning vector quantization (LVQ). These learning algorithms extend the concept of adaptive distance measures in LVQ to the use of relevance matrices. In general, metric learning can displa

  20. The COMPADRE Plant Matrix Database

    DEFF Research Database (Denmark)

    2014-01-01

    COMPADRE contains demographic information on hundreds of plant species. The data in COMPADRE are in the form of matrix population models and our goal is to make these publicly available to facilitate their use for research and teaching purposes. COMPADRE is an open-access database. We only request...

  1. Student Transfer Matrix, Fall 1996.

    Science.gov (United States)

    Oklahoma State Regents for Higher Education, Oklahoma City.

    The Student Transfer Matrix provides data on the numbers of students transferring from Oklahoma public and private institutions of higher education to other Oklahoma institutions, using data from receiving institutions. Among the highlights are: the number of students who transferred to four-year and two-year institutions remained steady at 57.8…

  2. Hyper-systolic matrix multiplication

    NARCIS (Netherlands)

    Lippert, Th.; Petkov, N.; Palazzari, P.; Schilling, K.

    2001-01-01

    A novel parallel algorithm for matrix multiplication is presented. It is based on a 1-D hyper-systolic processor abstraction. The procedure can be implemented on all types of parallel systems. (C) 2001 Elsevier Science B,V. All rights reserved.

  3. S matrix for absorptive Hamiltonians

    International Nuclear Information System (INIS)

    The existence of a matrix S such that SS = 1 in the presence of absorption is demonstrated. In the limit a of hermitian Hamiltonian the unitarity conditions SS = 1 is recovered. A dispersion relation for forward scattering is derived and the properties of the reactance matrices K and K are obtained. It is shown that K = K

  4. Bilateral matrix-exponential distributions

    DEFF Research Database (Denmark)

    Bladt, Mogens; Esparza, Luz Judith R; Nielsen, Bo Friis

    2012-01-01

    In this article we define the classes of bilateral and multivariate bilateral matrix-exponential distributions. These distributions have support on the entire real space and have rational moment-generating functions. These distributions extend the class of bilateral phasetype distributions of [1]...

  5. Survey of aluminum matrix composites

    International Nuclear Information System (INIS)

    This is a review of the current stage of development of fiber reinforced Al matrix composites: primary and secondary fabrication, physical and mechanical properties, environmental effects, applications, current and projected costs of raw material and composites, and future developments. Boron and beryllium are among the filament materials. (101 references, 32 fig.) (U.S.)

  6. Multivariate Modelling via Matrix Subordination

    DEFF Research Database (Denmark)

    Nicolato, Elisa

    stochastic volatility via time-change is quite ineffective when applied to the multivariate setting. In this work we propose a new class of models, which is obtained by conditioning a multivariate Brownian Motion to a so-called matrix subordinator. The obtained model-class encompasses the vast majority...

  7. Parallel Sparse Matrix - Vector Product

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Lazarov, Boyan Stefanov; Dammann, Bernd

    This technical report contains a case study of a sparse matrix-vector product routine, implemented for parallel execution on a compute cluster with both pure MPI and hybrid MPI-OpenMP solutions. C++ classes for sparse data types were developed and the report shows how these class can be used...

  8. The Lucas p-matrix

    Science.gov (United States)

    Kuhapatanakul, Kantaphon

    2015-11-01

    In this note, we study the Fibonacci and Lucas p-numbers. We introduce the Lucas p-matrix and companion matrices for the sums of the Fibonacci and Lucas p-numbers to derive some interesting identities of the Fibonacci and Lucas p-numbers.

  9. Injectable bone substitute using a hydrophilic polymer.

    OpenAIRE

    Weiss, Pierre; Gauthier, Olivier; Bouler, Jean-Michel; Grimandi, Gaël; Daculsi, Guy

    1999-01-01

    We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed of complex fluids whose flow is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube. The stability of the polymer and the mixture is essential to the production of a ready-to-use injectable biomaterial. These flow properties are necessary to o...

  10. Peculiarities in the carbon substitution of MgB{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Jemima Balaselvi, S.; Gayathri, N.; Bharathi, A.; Sastry, V.S.; Hariharan, Y

    2004-08-01

    To examine the role of kinetics on C substitution into MgB{sub 2}, heat treatments at 900 deg. C on stoichiometric quantities of Mg, B and C forming the MgB{sub 2-x}C{sub x} series, have been carried out for various times and for different carbon fractions, under an external Ar pressure of 50 Bar. The variation in the superconducting transition temperatures on account of C incorporation into the MgB{sub 2} matrix has been measured using the onset of diamagnetism and the appearance of zero resistance using the a.c. susceptibility and resistivity measurements carried out in the 4-300 K temperature range. The phase purity of the samples and the lattice parameters have been measured by XRD measurements. The microstructure has been characterized by scanning electron microscope observations. The heat treatments carried out on MgB{sub 2-x}C{sub x} for a nominal composition of x=0.3, indicate that for shorter periods, the superconducting transitions are broad, and with increase in the heat treatment time the transition widths narrow and the onset of diamagnetism shifts to higher temperature reaching a value of 35 K at 50 h. The a-lattice parameter shows a corresponding increase with heat treatment time and also attains a constant value between the 24 and 50 h treatments. These results reveal that the extent of carbon substituted into the MgB{sub 2} matrix at shorter times is large whereas for longer annealing times the matrix is depleted in carbon content, with carbon content in the superconducting volume becoming more uniform. These prolonged heat treatments were carried out for several nominal compositions of carbon and the measured T{sub C} decreases to less than 20 K for large carbon contents. The T{sub C} versus a-lattice parameter obtained from this work, shows a correlation in agreement with similar measurements on single crystals.

  11. The HDTV digital audio matrix

    Science.gov (United States)

    Mason, A. J.

    Multichannel sound systems are being studied as part of the Eureka 95 and Radio-communication Bureau TG10-1 investigations into high definition television. One emerging sound system has five channels; three at the front and two at the back. This raises some compatibility issues. The listener might have only, say, two loudspeakers or the material to be broadcast may have fewer than five channels. The problem is how best to produce a set of signals to be broadcast, which is suitable for all listeners, from those that are available. To investigate this area, a device has been designed and built which has six input channels and six output channels. Each output signal is a linear combination of the input signals. The inputs and outputs are in AES/EBU digital audio format using BBC-designed AESIC chips. The matrix operation, to produce the six outputs from the six inputs, is performed by a Motorola DSP56001. The user interface and 'housekeeping' is managed by a T222 transputer. The operator of the matrix uses a VDU to enter sets of coefficients and a rotary switch to select which set to use. A set of analog controls is also available and is used to control operations other than the simple compatibility matrixing. The matrix has been very useful for simple tasks: mixing a stereo signal into mono, creating a stereo signal from a mono signal, applying a fixed gain or attenuation to a signal, exchanging the A and B channels of an AES/EBU bitstream, and so on. These are readily achieved using simple sets of coefficients. Additions to the user interface software have led to several more sophisticated applications which still consist of a matrix operation. Different multichannel panning laws have been evaluated. The analog controls adjust the panning; the audio signals are processed digitally using a matrix operation. A digital SoundField microphone decoder has also been implemented. digital audio matrix is such that it can be applied to a wide variety of signal processing

  12. Performance of the Cement Matrix Composite Material With Rubber Powder

    Institute of Scientific and Technical Information of China (English)

    SONG Shao-min; LIU Juan-hong; ZHANG Xi-qing

    2004-01-01

    The effect of the deferent rubber content substituted for fine aggregate on the mortar performancewas studied. The effects of the rubber coated with the coating materials on the mortar compressive strength, bendingstrength and impact work were discussed. The optimum rubber powder content and the suitable coating materialwere found. Through the electrical probe test- BEI, SEI and calcium ion distribution, and the slight crack and theinterface between the rubber and cement matrix are analyzed. The results show that the rubber powder coated withthe surface treatment materials A, B and C bas the capability of absorbing a large amount of energy under thecompressive and flexural load and the slight cracks of R- C were controlled and restrained.

  13. A DIRECT ALGORITHM FOR DISTINGUISHING NONSINGULAR M-MATRIX AND H-MATRIX

    Institute of Scientific and Technical Information of China (English)

    Li Yaotang; Zhu Yan

    2005-01-01

    A direct algorithm is proposed by which one can distinguish whether a matrix is an M-matrix (or H-matrix) or not quickly and effectively. Numerical examples show that it is effective and convincible to distinguish M-matrix (or H-matrix) by using the algorithm.

  14. The Possibility of the Formation of Protocells and Their Structural Components on the Basis of the Apatite Matrix and Cocrystallizing Minerals

    OpenAIRE

    Kostetsky, Eduard Y.

    2005-01-01

    This paper presents the author's theory on the possibility of simultaneous hard-phase synthesis of various organic molecules from gas-phase elements on the basis of the apatite matrix and cocrystallizing minerals (carbonate-apatite, calcite, mica). These molecules and their ensembles gave rise to living systems and protocells of the pro- and eukaryotic types. Synthesis might have occurred through gradual substitution of the mineral matrix by crystal organic matter. The structure and size of t...

  15. Search Engine Advertising: Channel Substitution when Pricing Ads to Context

    OpenAIRE

    Avi Goldfarb; Catherine Tucker

    2010-01-01

    We explore substitution patterns across advertising platforms. Using data on the advertising prices paid by lawyers for 139 Google search terms in 195 locations, we exploit a natural experiment in "ambulance-chaser" regulations across states. When lawyers cannot contact clients by mail, advertising prices per click for search engine advertisements are 5%-7% higher. Therefore, online advertising substitutes for offline advertising. This substitution toward online advertising is strongest in ma...

  16. Practical problems in use of sugar substitutes in preventive dentistry

    OpenAIRE

    N M Roshan; Sakeenabi, B.

    2011-01-01

    Sugar (sucrose) being most acceptable sweetening agent in use by mankind is considered as the “Arch Criminal” in dental caries initiation. Search for suitable sweetening agent which will satisfy all the characteristics of sugar along with being non-cariogenic is going on since decades. At this given point of time, there is no such substitute which will replace sugar in all aspects, but, cariogenic potential can certainly be reduced by using sugar substitutes. Recently, few sugar substitutes a...

  17. Bone graft substitutes for spine fusion: A brief review

    OpenAIRE

    Gupta, Ashim; Kukkar, Nitin; Sharif, Kevin; Main, Benjamin J; Albers, Christine E; El-Amin III, Saadiq F

    2015-01-01

    Bone graft substitutes are widely used in the field of orthopedics and are extensively used to promote vertebral fusion. Fusion is the most common technique in spine surgery and is used to treat morbidities and relieve discomfort. Allograft and autograft bone substitutes are currently the most commonly used bone grafts to promote fusion. These approaches pose limitations and present complications to the patient. Numerous alternative bone graft substitutes are on the market or have been develo...

  18. Management of Substitution in English-Chinese Trans lation

    Institute of Scientific and Technical Information of China (English)

    杜宇飞

    2015-01-01

    Substitution is one of the major cohesive devices.Both English and Chinese use substitution.But due to the differences between the two languages,the translation methods adopted should vary according to the situation.This thesis aims to explore the different strategies that can be used in the translation of substitution from English to Chinese in different cases.A contrastive study between the two languages is crucial in this process.

  19. Cannabis as a substitute for alcohol and other drugs

    OpenAIRE

    Reiman Amanda

    2009-01-01

    Abstract Background Substitution can be operationalized as the conscious choice to use one drug (legal or illicit) instead of, or in conjunction with, another due to issues such as: perceived safety; level of addiction potential; effectiveness in relieving symptoms; access and level of acceptance. This practice of substitution has been observed among individuals using cannabis for medical purposes. This study examined drug and alcohol use, and the occurrence of substitution among medical cann...

  20. Tissue reaction and material characteristics of four bone substitutes

    DEFF Research Database (Denmark)

    Jensen, S S; Aaboe, M; Pinholt, E M;

    1996-01-01

    The aim of the present study was to qualitatively and quantitatively compare the tissue reactions around four different bone substitutes used in orthopedic and craniofacial surgery. Cylinders of two bovine bone substitutes (Endobon and Bio-Oss) and two coral-derived bone substitutes (Pro Osteon 500......-Oss was osseointegrated to a higher degree than the other biomaterials. Material characteristics obtained by diffuse reflectance infrared Fourier transform spectrometry analysis and energy-dispersive spectrometry did not explain the differences in biologic behavior....

  1. Management of Substitution in English-Chinese Trans lation

    Institute of Scientific and Technical Information of China (English)

    杜宇飞

    2015-01-01

    Substitution is one of the major cohesive devices. Both English and Chinese use substitution. But due to the differences between the two languages, the translation methods adopted should vary according to the situation. This thesis aims to explore the different strategies that can be used in the translation of substitution from English to Chinese in different cases. A contrastive study between the two languages is crucial in this process.

  2. ADULTRATION AND SUBSTITUTION IN HERBAL DRUGS: A CRITICAL ANAYSIS

    OpenAIRE

    Poornima B

    2010-01-01

    The adulteration and Substitution of the herbal drugs is the burning problem in herbal industry and it has caused a major treat in the research on commercial natural products. The deforestation and extinction of many species and incorrect identification of many plants has resulted in adulteration and substitution of raw drugs. The concept of substitution prevailed ages back and in Ayurveda we can find this in the treatise of Bhavaprakasha and Yogaratnakara.This article throws the light on th...

  3. Structure and Aromaticity of AlCO-substituted Semibullvalene

    Institute of Scientific and Technical Information of China (English)

    YAO Wen-Zhi; WU Hai-Shun

    2007-01-01

    The structures, energies and aromaticity (the nuclear-independent chemical shifts,NICS) of AlCO-substituted semibullvalenes were investigated at the B3LYP/6-311+G** level.Similar to BCO-substituted analogues, [2,6]-AlCO-semibullvalene is neutral bishomoaromatic.The NICS values reveal that the aromaticity of AlCO-substituted structures is smaller than that of BCO analogues.

  4. State generic substitution laws can lower drug outlays under medicaid

    OpenAIRE

    Shrank, William H.; Choudhry, Niteesh K.; Agnew-Blais, Jessica; Federman, Alex D.; Liberman, Joshua N.; LIU Jun; Aaron S Kesselheim; Brookhart, M. Alan; Fischer, Michael A

    2010-01-01

    To stem the rising costs of medications, states have implemented varying generic substitution policies. These policies differ in the extent to which pharmacists or patients can influence medication choice. Using national Medicaid data, we evaluated the relationship between different generic substitution policies and generic simvastatin use after patent expiration of branded Zocor. States implementing policies that require patient consent prior to generic substitution experienced 25% lower rat...

  5. Generation of a Fibrin Based Three-Layered Skin Substitute

    OpenAIRE

    Johanna Kober; Alfred Gugerell; Melanie Schmid; Lars-Peter Kamolz; Maike Keck

    2015-01-01

    A variety of skin substitutes that restore epidermal and dermal structures are currently available on the market. However, the main focus in research and clinical application lies on dermal and epidermal substitutes whereas the development of a subcutaneous replacement (hypodermis) is often disregarded. In this study we used fibrin sealant as hydrogel scaffold to generate a three-layered skin substitute. For the hypodermal layer adipose-derived stem cells (ASCs) and mature adipocytes were emb...

  6. A fast algorithm for sparse matrix computations related to inversion

    Science.gov (United States)

    Li, S.; Wu, W.; Darve, E.

    2013-06-01

    We have developed a fast algorithm for computing certain entries of the inverse of a sparse matrix. Such computations are critical to many applications, such as the calculation of non-equilibrium Green's functions Gr and Gcost of FIND. The other problem is that the partitioning scheme used by FIND is incompatible with most existing partitioning methods and libraries for nested dissection, which all use width-1 separators. Our new algorithm resolves these problems by thoroughly decomposing the computation process such that width-1 separators can be used, resulting in a significant speedup over FIND for realistic devices — up to twelve-fold in simulation. The new algorithm also has the added advantage that desired off-diagonal entries can be computed for free. Consequently, our algorithm is faster than the current state-of-the-art recursive methods for meshes of any size. Furthermore, the framework used in the analysis of our algorithm is the first attempt to explicitly apply the widely-used relationship between mesh nodes and matrix computations to the problem of multiple eliminations with reuse of intermediate results. This framework makes our algorithm easier to generalize, and also easier to compare against other methods related to elimination trees. Finally, our accuracy analysis shows that the algorithms that require back-substitution are subject to significant extra round-off errors, which become extremely large even for some well-conditioned matrices or matrices with only moderately large condition numbers. When compared to these back-substitution algorithms, our algorithm is generally a few orders of magnitude more accurate, and our produced round-off errors stay at a reasonable level.

  7. Substitutions between Water and other Agricultural Inputs - An Empirical Analysis

    Science.gov (United States)

    Cai, X.; You, J.

    2005-12-01

    Increasing concerns about water availability, environmental water requirement and water quality have led to an increased importance of quantitative assessments of the substitution between water and other agricultural inputs at the margin for agricultural and environmental policy analysis. This paper explores the potential substitutions between water and other agricultural inputs in irrigated agriculture through an empirical study. The study include (1) an analysis based on a crop production function for net substitution at the crop field and farm levels; and (2) a numerical study for gross substitution in the context of water allocation in river basins thorough an integrated hydrologic-economic river basin model. Along with the empirical analysis and numerical illustrations, we discuss several theoretical issues relevant to substitutions between water and other inputs, such as (1) selection of indicators of elasticity of substitution, depending on farmers' concerns on yield, production, or profit; (2) appropriateness of net or gross substitution analysis, which is relevant to the spatial scale of the analysis (field, district or region), as well as farmers' concerns; and (3) output impact of substitutions. Water is both a natural resource and an economic input, and the constraints on water include those from both physical and socio-economic aspects. Therefore, the output impact of the substitution between water and other inputs should be extended from a pure economic concept to the context of integrated hydrologic-economic systems.

  8. ARE THE PROFESSIONAL ENGINEERING SERVICES THREATENED BY SUBSTITUTES?

    Directory of Open Access Journals (Sweden)

    Gabriel Sorin STROE

    2014-06-01

    Full Text Available Substitutes pose a permanent threat on firms’ products or services in any industry. As the extant literature on strategic analysis is abundant in examples of substitutes for goods and traditional services, the paper aims at analyzing in-depth the concept of substitutes in the case of engineering services industry which is a knowledge-based, project-based, and professional type one. The assessment of the threat of substitutes for these services has been supported by an empirical study among a number of managers of Romanian engineering companies. The paper ends up with a set of conclusions and an invitation to further debate and research.

  9. Import Substitution in Regional Industrial Production: Theoretical and Practical Aspects

    Directory of Open Access Journals (Sweden)

    Yevgeniy Georgievich Animitsa

    2015-09-01

    Full Text Available The article proves the important role of import substitution in the economic security protection of state and its regions, especially in times of crisis, geopolitical and economical instability. The authors argue that the problem of import substitution is not modern, trendy scientific stream. The issue of displacement of import goods by domestic ones was brought up in famous classic theories of mercantilists. The particular emphasis is placed on the analysis and systematization of different scientific approaches, which are utilized by native and foreign scientists to bring out the matter of “import substitution,” to determine its essential characteristics. The authors suggest their own interpretation of the import substitution notion. In the article, the most significant pro and contra arguments in import substitution policy are defined. The regional aspects in the import substitution are approved: case study — organization of industrial import substitution in the Sverdlovsk region. In the article, the authors analyze the subject matter of the Program “Development of Intraregional Industrial Cooperation and Implementation of an Import Substitution in Branches of Industry in the Sverdlovsk Region.” It is resumed, that active policy of import substitution in the industry may become the driver of regional economic development.

  10. Generalized $\\beta$-expansions, substitution tilings, and local finiteness

    OpenAIRE

    Frank, Natalie Priebe; Robinson, Jr., W. Edward

    2005-01-01

    For a fairly general class of two-dimensional tiling substitutions, we prove that if the length expansion $\\beta$ is a Pisot number, then the tilings defined by the substitution must be locally finite. We also give a simple example of a two-dimensional substitution on rectangular tiles, with a non-Pisot length expansion $\\beta$, such that no tiling admitted by the substitution is locally finite. The proofs of both results are effectively one-dimensional and involve the idea of a certain type ...

  11. Development of a piezoelectric bone substitute material

    CERN Document Server

    Al-Bader, Y A

    2000-01-01

    The thesis deals with the preparation and testing of ceramic compositions to be used as bone substitute. The proposed composition consisted of calcium enriched calcium phosphate, kaolin and barium titanate in different ratios. The homogeneous powder mixture was dry pressed at different pressures and fired at temperatures up to 1350 degC for different soaking times. The physical properties of the fired compacts that were tested are bulk density and porosity. These were determined as function of pressing pressure, firing temperature and soaking time for different compositions. The mechanical properties investigated were the ultimate compressive strength and Young's modulus, which were determined for different compositions and forming pressures. The electrical properties investigated were D.C. characteristics (resistivity) and A.C. characteristics (A.C. resistivity, dielectric constant, dielectric loss and loss tangent). The piezoelectric behaviour of the fired compacts was investigated and the piezoelectric coe...

  12. Substitutions in dynamics, arithmetics and combinatorics

    CERN Document Server

    Berthé, Valéré; Ferenczi, Sébastien; Mauduit, Christian; Siegel, Anne

    2002-01-01

    A certain category of infinite strings of letters on a finite alphabet is presented here, chosen among the 'simplest' possible one may build, both because they are very deterministic and because they are built by simple rules (a letter is replaced by a word, a sequence is produced by iteration). These substitutive sequences have a surprisingly rich structure. The authors describe the concepts of quantity of natural interactions, with combinatorics on words, ergodic theory, linear algebra, spectral theory, geometry of tilings, theoretical computer science, diophantine approximation, trancendence, graph theory. This volume fulfils the need for a reference on the basic definitions and theorems, as well as for a state-of-the-art survey of the more difficult and unsolved problems.

  13. Testosterone Substitution: Current Modalities and Perspectives

    Directory of Open Access Journals (Sweden)

    Zitzmann M

    2006-01-01

    Full Text Available The clinical picture of male hypogonadism is associated with typical symptoms, such as disturbances of mood and cognitive abilities as well as sexual functions; furtheron, a decrease in muscle mass and strength, an accumulation of body fat and osteopenia/osteoporosis are observed. There are indications that insulin sensitivity is mitigated in a state of androgen depletion. In older men, symptoms of androgen deficiency (late-onset hypogonadism may exhibit a differential profile due to accompanying other chronic illnesses. Restoring serum testosterone levels by replacement therapy can markedly attenuate, if not relieve, the clinical picture of hypogonadism. Recently, new treatment modalities have been introduced, which include short-acting transdermal or buccal modalities as well as the long-acting depot preparation of testosterone undecanoate. This review summarises the pathways of diagnosis of male hypogonadism and discusses the various modern methods of initiation and surveillance of testosterone substitution therapy. Future perspectives regarding pharmacogenetic aspects are discussed.

  14. Tertiary fatty amides as diesel fuel substitutes

    Energy Technology Data Exchange (ETDEWEB)

    Serdari, Aikaterini; Lois, Euripides; Stournas, Stamoulis [National Technical Univ. of Athens, Dept. of Chemical Engineering, Athens (Greece)

    2000-07-01

    This paper presents experimental results regarding the impact of adding different tertiary amides of fatty acids to mineral diesel fuel; an assessment of the behaviour of these compounds as possible diesel fuel extenders is also included. Measurements of cetane number, cold flow properties (cloud point, pour point and CFPP), density, kinematic viscosity, flash point and distillation temperatures are reported, while initial experiments concerning the effects on particulate emissions are also described. Most of the examined tertiary fatty amides esters have very good performance and they can be easily prepared from fatty acids (biomass). Such compounds or their blends could be used as mineral diesel fuel or even fatty acid methylesters (FAME, biodiesel) substitutes or extenders. (Author)

  15. Sucrose and sucrose substitutes. Industrial considerations.

    Science.gov (United States)

    Mackay, D A

    1978-01-01

    The problem of reducing the sugar content of sugary foods is presented from the food manufacturer's point of view. The distinction is made between the need for artificial sweeteners and the more pressing need for bulking agents with at least some of the technological properties of sugar. In view of the considerable sales success of sugarless confections, accounting for over an estimated 30,000,000 lbs. of sorbitol per annum, the clouded prospect for more general sugar substitution in other food categories is discussed with especial reference to the consequent problems in product claims and nomenclature, and the enormous expense of proving safety and dental claims. Finally, an overview of the competitive consumer and regulatory pressures is given, with an urgent appeal to the dental profession to take the initiative for guiding the food processor to dentally improved foods.

  16. Hazardous Solvent Substitution Data System tutorial

    International Nuclear Information System (INIS)

    This manual is the tutorial for the Hazardous Solvent Substitution Data System (HSSDS), an online, comprehensive system of information on alternatives to hazardous solvents and related subjects. The HSSDS data base contains product information, material safety data sheets, toxicity reports, usage reports, biodegradable data, product chemical element lists, and background information on solvents. HSSDS use TOPIC reg-sign to search for information based on a query defined by the user. TOPIC provides a full text retrieval of unstructured source documents. In this tutorial, a series of lessons is provided that guides the user through basic steps common to most queries performed with HSSDS. Instructions are provided for both window-based and character-based applications

  17. Packing and Disorder in Substituted Fullerenes

    KAUST Repository

    Tummala, Naga Rajesh

    2016-07-15

    Fullerenes are ubiquitous as electron-acceptor and electron-transport materials in organic solar cells. Recent synthetic strategies to improve the solubility and electronic characteristics of these molecules have translated into a tremendous increase in the variety of derivatives employed in these applications. Here, we use molecular dynamics (MD) simulations to examine the impact of going from mono-adducts to bis- and tris-adducts on the structural, cohesive, and packing characteristics of [6,6]-phenyl-C60-butyric acid methyl ester (PCBM) and indene-C60. The packing configurations obtained at the MD level then serve as input for density functional theory calculations that examine the solid-state energetic disorder (distribution of site energies) as a function of chemical substitution. The variations in structural and site-energy disorders reflect the fundamental materials differences among the derivatives and impact the performance of these materials in thin-film electronic devices.

  18. 3-Substituted 2-phenyl-indoles

    DEFF Research Database (Denmark)

    Johansson, Karl Henrik; Jørgensen, T.B.; Gloriam, D.E.;

    2013-01-01

    Privileged structures have been used in drug discovery targeting G protein-coupled receptors (GPCR) and other protein classes for more than 20 years. Their rich activity profiles and drug-like characteristics lend themselves to increased productivity in hit identification and lead optimisation....... Recently we discovered two allosteric modulators 1 and 2 for the G protein-coupled receptor GPRC6A incorporating the privileged 2-phenyl-indole scaffold, functionalised at the 3-position. In order to develop new potential GPRC6A ligands we engaged in the development of synthetic routes to provide 2-phenyl......-indoles with a variety of substituents at the indole 3-position. Herein we describe the development of optimised and efficient synthetic routes to a series of new 2-phenyl-indole building blocks 3 to 9 and show that these can be used to generate a broad variety of 3-substituted 2-phenyl-indoles of interest to medicinal...

  19. Substituted Pyrazinecarboxamides: Synthesis and Biological Evaluation

    Directory of Open Access Journals (Sweden)

    Katarina Kralova

    2006-03-01

    Full Text Available Condensation of the corresponding chlorides of some substituted pyrazine-2-carboxylic acids (pyrazine-2-carboxylic acid, 6-chloropyrazine-2-carboxylic acid, 5-tert-butylpyrazine-2-carboxylic acid or 5-tert-butyl-6-chloropyrazine-2-carboxylic acid withvarious ring-substituted aminothiazoles or anilines yielded a series of amides. Thesyntheses, analytical and spectroscopic data of thirty newly prepared compounds arepresented. Structure-activity relationships between the chemical structures and the anti-mycobacterial, antifungal and photosynthesis-inhibiting activity of the evaluatedcompounds are discussed. 3,5-Bromo-4-hydroxyphenyl derivatives of substitutedpyrazinecarboxylic acid, 16-18, have shown the highest activity against Mycobacteriumtuberculosis H37Rv (54-72% inhibition. The highest antifungal effect againstTrichophyton mentagrophytes, the most susceptible fungal strain tested, was found for5-tert-butyl-6-chloro-N-(4-methyl-1,3-thiazol-2-ylpyrazine-2-carboxamide (8, MIC =31.25 μmol·mL-1. The most active inhibitors of oxygen evolution rate in spinachMolecules 2006, 11 243 chloroplasts were the compounds 5-tert-butyl-6-chloro-N-(5-bromo-2-hydroxyphenyl- pyrazine-2-carboxamide (27, IC50 = 41.9 μmol·L-1 and 5-tert-butyl-6-chloro-N-(1,3- thiazol-2-yl-pyrazine-2-carboxamide (4, IC50 = 49.5 μmol·L-1.

  20. The influence of substituted phenols on the sol:gel transition of hydroxypropyl methylcellulose (HPMC) aqueous solutions.

    Science.gov (United States)

    Banks, Simon R; Pygall, Samuel R; Bajwa, Gurjit S; Doughty, Stephen W; Timmins, Peter; Melia, Colin D

    2014-01-30

    The influence of the physicochemical parameters of substituted aromatic molecules on the phase transition from sol to gel of hydroxypropyl methylcellulose (HPMC) has been investigated using a homologous series of substituted phenols. Using a turbimetric methodology, concentration dependent suppression of phase transition temperature of HPMC was observed for phenol and its derivatives, including methyl-, nitro- and chloro-substituted molecules. Although no strong direct relationship between single molecular physicochemical properties of the phenolic compounds (such as pKa, LogP and other molecular descriptors) and ΔCPT was found for the compounds tested, a successful prediction of behaviour could be obtained by using a combination of parameters. This suggested that the interaction mechanism between HPMC and the substituted aromatic moiety is a complex summation of the different molecular physicochemical properties. Identification of these potentially deleterious chemical moieties may be of value in a pharmaceutical context when considering preformulation of drug structures containing them. An incompatibility between drug and polymer may be indicative of deleterious effects resulting from formulation with hydrophilic matrix dosage forms containing cellulose ethers such as HPMC. PMID:24299892

  1. The Benefit of Currency Substitution during High Inflation and Stabilization The Benefit of Currency Substitution during High Inflation and Stabilization

    OpenAIRE

    Jacek Rostowski

    1992-01-01

    Allowing currency substitution in a very high inflation helps to maintain the level of output, as, the distortion of the information carried by prices is mitigated. The total (primary plus secondary) money supply may increase if currency substitution is permitted. Currency substitution does not even necessarily reduce the real primary money stock. Moreover, the demand for the primary money fragments at very high rates of inflation, which means that the authorities may loose little when they g...

  2. The Constrained Solutions of Two Matrix Equations

    Institute of Scientific and Technical Information of China (English)

    An Ping LIAO; Zhong Zhi BAI

    2002-01-01

    We study the symmetric positive semidefinite solution of the matrix equation AX1AT +BX2BT = C, where A is a given real m × n matrix, B is a given real m × p matrix, and C is a givenreal m × m matrix, with m, n, p positive integers; and the bisymmetric positive semidefinite solutionof the matrix equation DTXD = C, where D is a given real n × m matrix, C is a given real m × mmatrix, with m, n positive integers. By making use of the generalized singular value decomposition, wederive general analytic formulae, and present necessary and sufficient conditions for guaranteeing theexistence of these solutions.

  3. Scrambling with matrix black holes

    Science.gov (United States)

    Brady, Lucas; Sahakian, Vatche

    2013-08-01

    If black holes are not to be dreaded sinks of information but rather fully described by unitary evolution, they must scramble in-falling data and eventually leak it through Hawking radiation. Sekino and Susskind have conjectured that black holes are fast scramblers; they generate entanglement at a remarkably efficient rate, with the characteristic time scaling logarithmically with the entropy. In this work, we focus on Matrix theory—M-theory in the light-cone frame—and directly probe the conjecture. We develop a concrete test bed for quantum gravity using the fermionic variables of Matrix theory and show that the problem becomes that of chains of qubits with an intricate network of interactions. We demonstrate that the black hole system evolves much like a Brownian quantum circuit, with strong indications that it is indeed a fast scrambler. We also analyze the Berenstein-Maldacena-Nastase model and reach the same tentative conclusion.

  4. Matrix Factorization for Evolution Data

    Directory of Open Access Journals (Sweden)

    Xiao-Yu Huang

    2014-01-01

    Full Text Available We study a matrix factorization problem, that is, to find two factor matrices U and V such that R≈UT×V, where R is a matrix composed of the values of the objects O1,O2,…,On at consecutive time points T1,T2,…,Tt. We first present MAFED, a constrained optimization model for this problem, which straightforwardly performs factorization on R. Then based on the interplay of the data in U, V, and R, a probabilistic graphical model using the same optimization objects is constructed, in which structural dependencies of the data in these matrices are revealed. Finally, we present a fitting algorithm to solve the proposed MAFED model, which produces the desired factorization. Empirical studies on real-world datasets demonstrate that our approach outperforms the state-of-the-art comparison algorithms.

  5. The eWOM Matrix

    DEFF Research Database (Denmark)

    Martensen, Anne; Jensen, J.S; Gyrd-Jones, Richard

    contributes to the literature by examining how a company can gain insights about the images held by its customers by analysing eWOM reviews on web-based consumer opinion platforms. Companies can thus directly measure and track which touch-points their customers are referring to in their eWOM reviews. We...... discuss how to categorise and quantify these eWOM reviews based on research within WOM, customer satisfaction and the disconfirmation of expectation paradigm combined with research within customer experience management and its focus on customer touch points. We then propose a conceptual framework – the e......WOM Matrix - where the customers’ touch points are the strategic connection between analysis and implementation of eWOM issues. The eWOM Matrix serves as a management tool, visually assisting companies to explore about which touch-points their customers’ primarily construct negative or positive e...

  6. Distributed-memory matrix computations

    DEFF Research Database (Denmark)

    Balle, Susanne Mølleskov

    1995-01-01

    The main goal of this project is to investigate, develop, and implement algorithms for numerical linear algebra on parallel computers in order to acquire expertise in methods for parallel computations. An important motivation for analyzaing and investigating the potential for parallelism...... in these algorithms is that many scientific applications rely heavily on the performance of the involved dense linear algebra building blocks. Even though we consider the distributed-memory as well as the shared-memory programming paradigm, the major part of the thesis is dedicated to distributed-memory architectures....... Several areas in the numerical linear algebra field are investigated and they illustrate the problems that arise as well as the techniques that are related to the use of massively parallel computers: 1.Study of Strassen's matrix-matrix multiplication on the Connection Machine model CM-200. What...

  7. The Simplest Neutrino Mass Matrix

    CERN Document Server

    Harrison, P F

    2004-01-01

    We motivate the simplest ansatz for the neutrino mass matrix consistent with the data from neutrino oscillation experiments, and admitting CP violation. It has only two free parameters: an arbitrary mass-scale and a small dimensionless ratio. This mass matrix exhibits two symmetries, Democracy and Mutativity, which respectively ensure trimaximal mixing of the |nu_2> mass eigenstate, and mixing parameter values |theta_{23}|=45 degrees and |delta|=90 degrees, consistent with bimaximal mixing of the |nu_3> mass eigenstate. A third constraint relates the smallness of |U_{e3}|^2 to that of the mass-squared difference ratio, Delta m^2_sol/Delta m^2_atm, yielding the prediction sin(theta_{13})=sqrt{2 Delta m^2_sol/3 Delta m^2_atm} ~ 0.13 +- 0.03.

  8. Link Prediction via Matrix Completion

    CERN Document Server

    Pech, Ratha; Pan, Liming; Cheng, Hong; Zhou, Tao

    2016-01-01

    Inspired by practical importance of social networks, economic networks, biological networks and so on, studies on large and complex networks have attracted a surge of attentions in the recent years. Link prediction is a fundamental issue to understand the mechanisms by which new links are added to the networks. We introduce the method of robust principal component analysis (robust PCA) into link prediction, and estimate the missing entries of the adjacency matrix. On one hand, our algorithm is based on the sparsity and low rank property of the matrix, on the other hand, it also performs very well when the network is dense. This is because a relatively dense real network is also sparse in comparison to the complete graph. According to extensive experiments on real networks from disparate fields, when the target network is connected and sufficiently dense, whatever it is weighted or unweighted, our method is demonstrated to be very effective and with prediction accuracy being considerably improved comparing wit...

  9. Matrix metalloproteinases in lung biology

    Directory of Open Access Journals (Sweden)

    Parks William C

    2000-12-01

    Full Text Available Abstract Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and repair, among other events. Overexpression of MMPs, however, has also been blamed for much of the tissue destruction associated with lung inflammation and disease. Beyond their role in the turnover and degradation of extracellular matrix proteins, MMPs also process, activate, and deactivate a variety of soluble factors, and seldom is it readily apparent by presence alone if a specific proteinase in an inflammatory setting is contributing to a reparative or disease process. An important goal of MMP research will be to identify the actual substrates upon which specific enzymes act. This information, in turn, will lead to a clearer understanding of how these extracellular proteinases function in lung development, repair, and disease.

  10. Matrix dynamics of fuzzy spheres

    CERN Document Server

    Jatkar, D P; Wadia, S R; Yogendran, K P; Jatkar, Dileep P.; Mandal, Gautam; Wadia, Spenta R.

    2002-01-01

    We study the dynamics of fuzzy two-spheres in a matrix model which represents string theory in the presence of RR flux. We analyze the stability of known static solutions of such a theory which contain commuting matrices and SU(2) representations. We find that irreducible as well as reducible representations are stable. Since the latter are of higher energy, this stability poses a puzzle. We resolve this puzzle by noting that reducible representations have marginal directions corresponding to non-spherical deformations. We obtain new static solutions by turning on these marginal deformations. These solutions now have instability or tachyonic directions. We discuss condensation of these tachyons which correspond to classical trajectories interpolating from multiple, small fuzzy spheres to a single, large sphere. We briefly discuss spatially independent configurations of a D3/D5 system described by the same matrix model which now possesses a supergravity dual.

  11. Clustering-Based Matrix Factorization

    OpenAIRE

    Mirbakhsh, Nima; Ling, Charles X.

    2013-01-01

    Recommender systems are emerging technologies that nowadays can be found in many applications such as Amazon, Netflix, and so on. These systems help users to find relevant information, recommendations, and their preferred items. Slightly improvement of the accuracy of these recommenders can highly affect the quality of recommendations. Matrix Factorization is a popular method in Recommendation Systems showing promising results in accuracy and complexity. In this paper we propose an extension ...

  12. Matrix Factorizations and Kauffman Homology

    CERN Document Server

    Gukov, S; Gukov, Sergei; Walcher, Johannes

    2005-01-01

    The topological string interpretation of homological knot invariants has led to several insights into the structure of the theory in the case of sl(N). We study possible extensions of the matrix factorization approach to knot homology for other Lie groups and representations. In particular, we introduce a new triply graded theory categorifying the Kauffman polynomial, test it, and predict the Kauffman homology for several simple knots.

  13. Coherence matrix of plasmonic beams

    DEFF Research Database (Denmark)

    Novitsky, Andrey; Lavrinenko, Andrei

    2013-01-01

    We consider monochromatic electromagnetic beams of surface plasmon-polaritons created at interfaces between dielectric media and metals. We theoretically study non-coherent superpositions of elementary surface waves and discuss their spectral degree of polarization, Stokes parameters, and the for...... of the spectral coherence matrix. We compare the polarization properties of the surface plasmonspolaritons as three-dimensional and two-dimensional fields concluding that the latter is superior....

  14. CFC substitutes for refrigeration engineering. FCKW-Substitute fuer die Kaeltetechnik

    Energy Technology Data Exchange (ETDEWEB)

    Henrici, R. (Hoechst AG, Forschung und Entwicklung Chemikalien, Frankfurt am Main (Germany))

    1993-12-01

    The international attempts ot protect the earth atmosphere have accelerated the world-wide search for CFC substitutes. Enormous efforts have been undertaken in the last few years to solve the problems occurring with new refrigerants and to find suitable lubricants. The article discusses the following subjects: Requirements on future refrigerants, effects on the ''greenhouse problem'', toxicological properties, problems in practical application, trends of development, refrigerant mixtures, conversion of older plants, recycling of refrigerants. (SR)

  15. Integrable matrix theory: Level statistics

    Science.gov (United States)

    Scaramazza, Jasen A.; Shastry, B. Sriram; Yuzbashyan, Emil A.

    2016-09-01

    We study level statistics in ensembles of integrable N ×N matrices linear in a real parameter x . The matrix H (x ) is considered integrable if it has a prescribed number n >1 of linearly independent commuting partners Hi(x ) (integrals of motion) "]Hi(x ) ,Hj(x ) ]">H (x ) ,Hi(x ) =0 , for all x . In a recent work [Phys. Rev. E 93, 052114 (2016), 10.1103/PhysRevE.93.052114], we developed a basis-independent construction of H (x ) for any n from which we derived the probability density function, thereby determining how to choose a typical integrable matrix from the ensemble. Here, we find that typical integrable matrices have Poisson statistics in the N →∞ limit provided n scales at least as logN ; otherwise, they exhibit level repulsion. Exceptions to the Poisson case occur at isolated coupling values x =x0 or when correlations are introduced between typically independent matrix parameters. However, level statistics cross over to Poisson at O (N-0.5) deviations from these exceptions, indicating that non-Poissonian statistics characterize only subsets of measure zero in the parameter space. Furthermore, we present strong numerical evidence that ensembles of integrable matrices are stationary and ergodic with respect to nearest-neighbor level statistics.

  16. MALDI Matrix Research for Biopolymers

    Science.gov (United States)

    Fukuyama, Yuko

    2015-01-01

    Matrices are necessary materials for ionizing analytes in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). The choice of a matrix appropriate for each analyte controls the analyses. Thus, in some cases, development or improvement of matrices can become a tool for solving problems. This paper reviews MALDI matrix research that the author has conducted in the recent decade. It describes glycopeptide, carbohydrate, or phosphopeptide analyses using 2,5-dihydroxybenzoic acid (2,5-DHB), 1,1,3,3-tetramethylguanidinium (TMG) salts of p-coumaric acid (CA) (G3CA), 3-aminoquinoline (3-AQ)/α-cyano-4-hydroxycinnamic acid (CHCA) (3-AQ/CHCA) or 3-AQ/CA and gengeral peptide, peptide containing disulfide bonds or hydrophobic peptide analyses using butylamine salt of CHCA (CHCAB), 1,5-diaminonaphthalene (1,5-DAN), octyl 2,5-dihydroxybenzoate (alkylated dihydroxybenzoate, ADHB), or 1-(2,4,6-trihydroxyphenyl)octan-1-one (alkylated trihydroxyacetophenone, ATHAP). PMID:26819908

  17. Sol-gel preparation and characterization of non-substituted and Sr-substituted gadolinium cobaltates

    International Nuclear Information System (INIS)

    An aqueous sol-gel chemistry approach for the preparation of Sr-substituted perovskite gadolinium cobaltates Gd1-xSrxCoO3-δ (x = 0.0, 0.25, 0.5 and 0.75) has been applied. The metal ions, generated by dissolving starting materials in diluted acetic acid were complexed by EDTA to obtain the precursors for non-substituted and Sr-substituted GdCoO3. However, only two single-phase cobaltate samples with x = 0.0 and 0.25 have been obtained by the suggested sol-gel method. The influences of synthesis temperature and the amount of substituent on the phase purity of Gd1-xSrxCoO3-δ were investigated. The evolution of the gels during heating, composition and micro-structural features in the polycrystalline samples was studied by thermal analysis (TG/DSC), infrared spectroscopy (IR), powder X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM).

  18. Design, Synthesis and Insecticidal Activities of Novel Phenyl Substituted Isoxazolecarboxamides

    Institute of Scientific and Technical Information of China (English)

    LIU Peng-fei; ZHANG Ji-feng; YAN Tao; XIONG Li-xia; LI Zheng-ming

    2012-01-01

    Thirteen novel phenyl substituted isoxazolecarboxamides were synthesized,and their structures were characterized by 1H NMR,elementary analysis and high-resolution mass spectrometry(HRMS) techniques.Their evaluated insecticidal activities against oriental armyworm(Mythimna separata) indicate that the phcnyl substituted isoxazolecarboxamides exhibited moderate insecticidal activities,among which compounds 9c and 9k showed comparatively higher activities.

  19. Introducing Aliphatic Substitution with a Discovery Experiment Using Competing Electrophiles

    Science.gov (United States)

    Curran, Timothy P.; Mostovoy, Amelia J.; Curran, Margaret E.; Berger, Clara

    2016-01-01

    A facile, discovery-based experiment is described that introduces aliphatic substitution in an introductory undergraduate organic chemistry curriculum. Unlike other discovery-based experiments that examine substitution using two competing nucleophiles with a single electrophile, this experiment compares two isomeric, competing electrophiles…

  20. 12 CFR 27.6 - Substitute monitoring program.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Substitute monitoring program. 27.6 Section 27.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM § 27.6 Substitute monitoring program. The recordkeeping provisions of § 27.3 constitute...

  1. Control of Chemical Risks by Substitution of Harmful Substances

    DEFF Research Database (Denmark)

    Jacobsen, Thomas

    1997-01-01

    Substitution of volatile, organic solvents with non-volatile, low-toxic esters of fatty acids for cleaning purposes in offset printing has successfully been implemented in several European countries. Similar substitutions in other industrial cleaning processes seem possible, especially regarding ...

  2. MOLECULAR THERMODYNAMICS IN THE DESIGN OF SUBSTITUTE SOLVENTS

    Science.gov (United States)

    The use of physical properties and fluid behavior from molecular thermodynamics can lead to better decision making in the design of substitute solvents and can greatly reduce the expense and time required to find substitutes compared to designing solvents by experiment. this pape...

  3. What Is Being Masked in Object Substitution Masking?

    Science.gov (United States)

    Gellatly, Angus; Pilling, Michael; Cole, Geoff; Skarratt, Paul

    2006-01-01

    Object substitution masking (OSM) is said to occur when a perceptual object is hypothesized that is mismatched by subsequent sensory evidence, leading to a new hypothesized object being substituted for the first. For example, when a brief target is accompanied by a longer lasting display of nonoverlapping mask elements, reporting of target…

  4. Exploring meat substitutes: consumer experiences and contextual factors

    NARCIS (Netherlands)

    Elzerman, J.E.; Boekel, van M.A.J.S.; Luning, P.A.

    2013-01-01

    Purpose – Meat substitutes can be environmentally more sustainable alternatives to meat. However, the image of these products in The Netherlands is still low. The purpose of this paper is to explore consumers' experiences and sensory expectations of meat substitutes and the appropriateness of the us

  5. Thermal stability of substitutional ag in CdTe

    NARCIS (Netherlands)

    Jahn, SG; Hofsass, H; Restle, M; Ronning, C; Quintel, H; BharuthRam, K; Wahl, U

    1996-01-01

    The thermal stability of substitutional Ag in CdTe was deduced from lattice location measurements at different temperatures. Substitutional Ag probe atoms were generated via transmutation doping from radioactive Cd isotopes. The lattice sites of Ag isotopes were determined by measuring the channelin

  6. 37 CFR 2.59 - Filing substitute specimen(s).

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Filing substitute specimen(s..., DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Drawing § 2.59 Filing substitute specimen(s). (a... specimen(s), the applicant must: (1) For an amendment to allege use under § 2.76, verify by affidavit...

  7. Generic substitution of antihypertensive drugs : does it affect adherence?

    NARCIS (Netherlands)

    Van Wijk, Boris L G; Klungel, Olaf H; Heerdink, Eibert R; de Boer, Anthonius

    2006-01-01

    BACKGROUND: Generic substitution is an important opportunity to reduce the costs of pharmaceutical care. However, pharmacists and physicians often find that patients and brand-name manufacturers have doubt about the equivalence of the substituted drug. This may be reflected by decreased adherence to

  8. An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

    Institute of Scientific and Technical Information of China (English)

    ZHU Peter C; WANG Dei-Haw; LU Kaitao; MANI Neelakandha

    2007-01-01

    Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis (dibromomethyl) benzenes with fuming sulfuric acid, followed by hydrolysis, The yields were significantly improved by introducing solid sodium bicarbonate into the reaction mixture before hydrolysis and workup.

  9. An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

    Institute of Scientific and Technical Information of China (English)

    ZHU; Peter; C; WANG; Der-Haw; MANI; Neelakandha

    2007-01-01

    Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis(dibromomethyl) benzenes with fuming sulfuric acid,followed by hydrolysis. The yields were signifi-cantly improved by introducing solid sodium bicarbonate into the reaction mixture before hydrolysis and workup.

  10. Exfoliation and thermal transformations of Nb-substituted layered titanates

    DEFF Research Database (Denmark)

    Song, H.; Sjåstad, Anja O.; Fjellvåg, Helmer;

    2011-01-01

    Single-layer Nb-substituted titanate nanosheets of ca. 1 nm thickness were obtained by exfoliating tetrabutylammonium (TBA)-intercalated Nb-substituted titanates in water. AFM images and turbidity measurements reveal that the exfoliated nanosheets crack and corrugate when sonicated. Upon heating,...

  11. RHEOLOGICAL ASPECTS OF MUCIN-CONTAINING SOLUTIONS AND SALIVA SUBSTITUTES

    NARCIS (Netherlands)

    HOLTERMAN, HJ; WATERMAN, HA; BLOM, C; SGRAVENMADE, FJ; Mellema, J.

    1992-01-01

    In this study rheological properties of aqueous solutions of mucin, albumin and mucin-albumin have been investigated in search for saliva substitutes. They were compared with commercially available saliva substitutes on the one hand and natural human saliva on the other hand. For the latter a few me

  12. 40 CFR 721.3880 - Polyalkylene glycol substituted acetate.

    Science.gov (United States)

    2010-07-01

    ... acetate. 721.3880 Section 721.3880 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Specific Chemical Substances § 721.3880 Polyalkylene glycol substituted acetate. (a) Chemical substance and... glycol substituted acetate (PMN P-91-1269) is subject to reporting under this section for the...

  13. Sublattice imbalance of substitutionally doped nitrogen in graphene

    DEFF Research Database (Denmark)

    Lawlor, James A.; Gorman, Paul D.; Power, Stephen;

    2014-01-01

    Motivated by the recently observed sublattice asymmetry of substitutional nitrogen impurities in CVD grown graphene, we show, in a mathematically transparent manner, that oscillations in the local density of states driven by the presence of substitutional impurities are responsible for breaking t......, but should be present in other impurities. (C) 2014 Elsevier Ltd. All rights reserved....

  14. Synthesis and antiinflammatory activity of substituted (2-oxochromen-3-ylbenzamides

    Directory of Open Access Journals (Sweden)

    Maddi V

    2007-01-01

    Full Text Available The title compounds were synthesized by condensing 3-aminocoumarin with substituted aromatic acid chlorides. The acid chlorides were prepared from different substituted aromatic carboxylic acids and thionyl chloride. The structures of the compounds were confirmed by IR, NMR spectral data and elemental analysis. The title compounds were found to possess significant anti-inflammatory and analgesic activities.

  15. 19 CFR 143.16 - Substitution of warehouse entry.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Substitution of warehouse entry. 143.16 Section 143.16 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... warehouse entry. The importer may substitute an entry for warehouse at any time within 1 year from the...

  16. Matrix Theory on Non-Orientable Surfaces

    OpenAIRE

    Zwart, Gysbert

    1997-01-01

    We construct the Matrix theory descriptions of M-theory on the Mobius strip and the Klein bottle. In a limit, these provide the matrix string theories for the CHL string and an orbifold of type IIA string theory.

  17. A New Proposal for Matrix Theory

    CERN Document Server

    Chaudhuri, S

    2002-01-01

    We give a detailed exposition of our recent proposal for Matrix Theory. Starting with the pedagogical case of bosonic matrix theory we identify a matrix Lagrangian whose large N limit coincides with the spacetime Lagrangian of an open and closed bosonic string theory. We describe the appearance of spacetime and of the basic elements of spacetime geometry in our framework. We identify the symmetry algebra governing the matrix Lagrangian at finite N and illustrate the phenomenon of matrix Dbrane democracy. The supersymmetric matrix Lagrangian is a nontrivial extension of the bosonic theory giving rise in the large N limit to the spacetime Lagrangians of supersymmetric open and closed string theories with Dbranes. We give a matrix path integral prescription for the Hartle-Hawking wavefunction of the Universe derived from Matrix Theory.

  18. Matrix Superpotential Linear in Variable Parameter

    CERN Document Server

    Karadzhov, Yuri

    2011-01-01

    The paper presents the classification of matrix valued superpotentials corresponding to shape invariant systems of Schr\\"odinger equations. All inequivalent irreducible matrix superpotentials realized by matrices of arbitrary dimension with linear dependence on variable parameter are presented explicitly.

  19. SINE TRANSFORM MATRIX FOR SOLVING TOEPLITZ MATRIX PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Li-zhi Cheng

    2001-01-01

    In recent papers, some authors studied the solutions of symmetricpositive definite(SPD) Toeplitz systems Tn x = b by the conjugate gradient method(CG) with different sine trans- forms based preconditioners. In this paper, we first discuss the properties of eigenvalues for the main known circulant, skew circulant and sine transform based preconditioners. A counter example shows that E.Boman's preconditioner is only positive semi-definite for the banded Toeplitz matrix. To use preconditioner effectively, then we propose a modified Boman's preconditioner and a new Cesaro sum type sine transform based preconditioner. Finally, the results of numerical experimentation with these two preconditioners are pre- sented.

  20. Hydrophobic core substitutions in calbindin D9k

    DEFF Research Database (Denmark)

    Kragelund, B B; Jönsson, M; Bifulco, G;

    1998-01-01

    Hydrophobic core residues have a marked influence on the Ca2+-binding properties of calbindin D9k, even though there are no direct contacts between these residues and the bound Ca2+ ions. Eleven different mutants with substitutions in the hydrophobic core were produced, and their equilibrium Ca2...... that the mutation causes only very minimal perturbations in the immediate vicinity of residue 61. Substitutions of alanines or glycines for bulky residues in the center of the core were found to have significant effects on both Ca2+ affinity and dissociation rates. These substitutions caused a reduction in affinity...... and an increase in off-rate. Small effects, both increases and decreases, were observed for substitutions involving residues far from the Ca2+ sites and toward the outer part of the hydrophobic core. The mutant with the substitution Phe66 --> Trp behaved differently from all other mutants, and displayed a 25-fold...

  1. Associations between generic substitution and patient-related factors

    DEFF Research Database (Denmark)

    Østergaard Rathe, Jette

    Associations between generic substitution and patient-related factors Jette Østergaard Rathe1, Pia V. Larsen1, Morten Andersen2, Janus L. Thomsen3, Maja S. Paulsen1, Jens Søndergaard1 1. Research Unit of General Practice, Institute of Public Health, University of Southern Denmark 2. Centre...... by definition are bioequivalent to their brand name counterparts there are concerns about whether generic substitution is always accompanied by clinical equivalence in terms of effectiveness and that it may cause concerns and thereby causing some skepticism towards generic substitution. There is, however...... generics in the antiepileptic and antidepressant groups (antiepileptics OR 0.37 and antidepressants OR 0.53). Conclusion We did not find any patient-related factors associated with generic substitution; however, patients who have once experienced a generic substitution with a specific drug are more likely...

  2. Traffic Matrix Reloaded: Impact of Routing Changes

    OpenAIRE

    Teixeira, Renata; Duffield, Nick; Rexford, Jennifer; Roughan, Matthew

    2005-01-01

    International audience A traffic matrix represents the load from each ingress point to each egress point in an IP network. Although networks are engineered to tolerate some variation in the traffic matrix, large changes can lead to congested links and poor performance. The variations in the traffic matrix are caused by statistical fluc-tuations in the traffic entering the network and shifts in where the traffic leaves the network. For an accurate view of how the traffic matrix evolves over...

  3. Bergman orthogonal polynomials and the Grunsky matrix

    OpenAIRE

    Beckermann, Bernhard; Stylianopoulos, Nikos

    2016-01-01

    By exploiting a link between Bergman orthogonal polynomials and the Grunsky matrix, probably first observed by Kühnau in 1985, we improve some recent results on strong asymptotics of Bergman polynomials outside the domain G of orthogonality, and on entries of the Bergman shift operator. In our proofs we suggest a new matrix approach involving the Grunsky matrix, and use well-established results in the literature relating properties of the Grunsky matrix to the regularity of the boundary of G,...

  4. Continued Fraction Algorithm for Matrix Exponentials

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A recursive rational algorithm for matrix exponentials was obtained by making use of the generalized inverse of a matrix in this paper. On the basis of the n-th convergence of Thiele-type continued fraction expansion, a new type of the generalized inverse matrix-valued Padé approximant (GMPA) for matrix exponentials was defined and its remainder formula was proved. The results of this paper were illustrated by some examples.

  5. Orthogonal Matrix-Valued Wavelet Packets

    Institute of Scientific and Technical Information of China (English)

    Qingjiang Chen; Cuiling Wang; Zhengxing Cheng

    2007-01-01

    In this paper,we introduce matrix-valued multiresolution analysis and matrixvalued wavelet packets. A procedure for the construction of the orthogonal matrix-valued wavelet packets is presented. The properties of the matrix-valued wavelet packets are investigated. In particular,a new orthonormal basis of L2(R,Cs×s) is obtained from the matrix-valued wavelet packets.

  6. How far can sodium substitute for potassium in red beet?

    Science.gov (United States)

    Subbarao, G. V.; Wheeler, R. M.; Stutte, G. W.; Levine, L. H.; Sager, J. C. (Principal Investigator)

    1999-01-01

    Sodium (Na) movement between plants and humans is one of the more critical aspects of bioregenerative systems of life support, which NASA is studying for the establishment of long-term bases on the Lunar or Martian surface. This study was conducted to determine the extent to which Na can replace potassium (K) in red beet (Beta vulgaris L. ssp vulgaris) without adversely affecting metabolic functions such as water relations, photosynthetic rates, and thus growth. Two cultivars, Ruby Queen and Klein Bol, were grown for 42 days at 1200 micromoles mol-1 CO2 in a growth chamber using a re-circulating nutrient film technique with 0%, 75%, 95%, and 98% Na substitution for K in a modified half-strength Hoagland solution. Total biomass of Ruby Queen was greatest at 95% Na substitution and equal at 0% and 98% Na substitution. For Klein Bol, there was a 75% reduction in total biomass at 98% Na substitution. Nearly 95% of the total plant K was replaced with Na at 98% Na substitution in both cultivars. Potassium concentrations in leaves decreased from 120 g kg-1 dwt in 0% Na substitution to 3.5 g kg-1 dwt at 98% Na substitution. Leaf chlorophyll concentration, photosynthetic rate, and osmotic potential were not affected in either cultivar by Na substitution for K. Leaf glycinebetaine levels were doubled at 75% Na substitution in Klein Bol, but decreased at higher levels of Na substitution. For Ruby Queen, glycinebetaine levels in leaf increased with the first increase of Na levels and were maintained at the higher Na levels. These results indicate that in some cultivars of red beet, 95% of the normal tissue K can be replaced by Na without a reduction in growth.

  7. An inversion algorithm for general tridiagonal matrix

    Institute of Scientific and Technical Information of China (English)

    Rui-sheng RAN; Ting-zhu HUANG; Xing-ping LIU; Tong-xiang GU

    2009-01-01

    An algorithm for the inverse of a general tridiagonal matrix is presented. For a tridiagonal matrix having the Doolittle factorization, an inversion algorithm is established.The algorithm is then generalized to deal with a general tridiagonal matrix without any restriction. Comparison with other methods is provided, indicating low computational complexity of the proposed algorithm, and its applicability to general tridiagonal matrices.

  8. P-15 small peptide bone graft substitute in the treatment of non-unions and delayed union. A pilot clinical trial

    OpenAIRE

    Gomar, Francisco; Orozco, Rafael; Villar, Jose Luis; Arrizabalaga, Federico

    2006-01-01

    Treatment of non-unions and delayed unions often requires osteogenic material. Recently, a biomimetic bone matrix that simulates the cellular environment of hard tissue, identified as P-15, was introduced to the orthopaedic community. A total of 22 patients with mal-union or delayed union fractures was treated from June 2000 to October 2003 with P15- bone graft substitute (P15-BGS) in the site of fracture and mostly with internal fixation. Patients were examined by independent radiographic an...

  9. Gd-substituted Bi-2223 superconductor

    Indian Academy of Sciences (India)

    D R Mishra

    2008-03-01

    The effects of gadolinium doping at calcium site on the normal and super-conducting properties of Bi-2223 system were studied. The Gd-doped (BiPb)-2223 series of specimens, namely Batch I, II and III were sintered at three different sintering temperatures 830, 850 and 895° C respectively. The properties investigated are (1) the normal state resistivity with a view to study metal-to-insulator transition, (2) the XRD patterns of the specimens with a view to study the relative composition of (BiPb)-2212 and (BiPb)-2223 phases and (3) the superconducting fluctuation behaviour (SFB) with a view to determine the effect of doping, if any, on the dimensionality of the fluctuation conductivity of the system. The normal state resistivity of Gd-substituted Bi-2223 specimens shows metallic, semiconducting and insulating behaviour. The c( = 0) values indicate that (BiPb)-2223 phase is responsible for the observed superconducting transitions in Batch I and Batch II specimens with Gd concentrations ≤ 0.7. This observation is further confirmed in the analysis of XRD patterns of these specimens. Gadolinium, being a magnetic impurity, has pair breaking effect near the Fermi level and decreases c( = 0). The analysis of the superconducting fluctuation behaviour (SFB) shows a 2D dimensionality without any cross-over.

  10. Production of Substitute Natural Gas from Coal

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Lucero

    2009-01-31

    The goal of this research program was to develop and demonstrate a novel gasification technology to produce substitute natural gas (SNG) from coal. The technology relies on a continuous sequential processing method that differs substantially from the historic methanation or hydro-gasification processing technologies. The thermo-chemistry relies on all the same reactions, but the processing sequences are different. The proposed concept is appropriate for western sub-bituminous coals, which tend to be composed of about half fixed carbon and about half volatile matter (dry ash-free basis). In the most general terms the process requires four steps (1) separating the fixed carbon from the volatile matter (pyrolysis); (2) converting the volatile fraction into syngas (reforming); (3) reacting the syngas with heated carbon to make methane-rich fuel gas (methanation and hydro-gasification); and (4) generating process heat by combusting residual char (combustion). A key feature of this technology is that no oxygen plant is needed for char combustion.

  11. Some comments on the substituted judgement standard.

    Science.gov (United States)

    Egonsson, Dan

    2010-02-01

    On a traditional interpretation of the substituted judgement standard (SJS) a person who makes treatment decisions on behalf of a non-competent patient (e.g. concerning euthanasia) ought to decide as the patient would have decided had she been competent. I propose an alternative interpretation of SJS in which the surrogate is required to infer what the patient actually thought about these end-of-life decisions. In clarifying SJS it is also important to differentiate the patient's consent and preference. If SJS is part of an autonomy ideal of the sort found in Kantian ethics, consent seems more important than preference. From a utilitarian perspective a preference-based reading of SJS seems natural. I argue that the justification of SJS within a utilitarian framework will boil down to the question whether a non-competent patient can be said to have any surviving preferences. If we give a virtue-ethical justification of SJS the relative importance of consent and preferences depends on which virtue one stresses--respect or care. I argue that SJS might be an independent normative method for extending the patient's autonomy, both from a Kantian and a virtue ethical perspective. PMID:19234760

  12. Hazardous Solvent Substitution Data System reference manual

    International Nuclear Information System (INIS)

    Concern for the environment, in addition to Federal regulation, mandate the replacement of hazardous solvents with safer cleaning agents. Manufacturers are working to produce these replacement solvents. As these products are developed, potential users need to be informed of their availability. To promote the use of these new products instead of traditional solvents, the Idaho National Engineering Laboratory (INEL) has developed the Hazardous Solvent Substitution Data System (HSSDS). The HSSDS provides a comprehensive system of information on alternatives to hazardous solvents and related subjects, and it makes that information available to solvent users, industrial hygienists, and process engineers. The HSSDS uses TOPIC reg-sign, a text retrieval system produced by Verity, Inc., to allow a user to search for information on a particular subject. TOPIC reg-sign produces a listing of the retrieved documents and allows the use to examine the documents individually and to use the information contained in them. This reference manual does not replace the comprehensive TOPIC reg-sign user documentation (available from Verity, Inc.), or the HSSDS Tutorial (available from the INEL). The purpose of this reference manual is to provide enough instruction on TOPIC reg-sign so the user may begin accessing the data contained in the HSSDS

  13. Energy conservation and substitution: refining the objectives

    Energy Technology Data Exchange (ETDEWEB)

    Foley, G.

    1981-06-01

    Energy conservation is not a precisely defined concept; consequently, there is a considerable confusion about how to implement it or predict its effects. Reducing dependence on oil should be the central objective of energy policy, but this may not be furthered by generalized conservation strategies. Achieving a reduction in oil dependence requires a balanced policy of conservation and substitution. As governments have reacted against oil price rises and the subsequent inflationary effects with a swing towards monetarism and a harsher reliance upon market forces, the role of oil has become even more important. Reliance upon these policies has not eased the oil blockage upon economic activity; it has made it worse and made the task of providing alternatives to oil more difficult. Market forces have had a wedging, rather than a freeing, effect upon the pattern of energy supply. But the point is that conservation, on its own, does not create the momentum away from oil which is essential. The immediate objective is not to achieve a reduction in the consumption of energy as an end in itself, but as part of a liberation from dependence upon oil. Energy conservation needs to be seen as a servant of this wider objective. 21 references.

  14. Pregabalin Abuse amongst Opioid Substitution Treatment Patients.

    Science.gov (United States)

    McNamara, S; Stokes, S; Kilduff, R; Shine, A

    2015-01-01

    Pregabalin (Lyrica®) is used in treating epilepsy, nerve pain and anxiety. Pregabalin was initially thought to have a low misuse potential however there are emerging reports of Pregabalin being abused. A study was commenced at the National Drug Treatment Centre's (NDTC) Drug Analysis Laboratory to determine the level of usage of Pregabalin within the addiction services population in Ireland. A total of 498 urine samples representing samples from 440 individual opioid substitution patients, initially screened by immunoassay for drugs of abuse, were subjected to further analysis for Pregabalin by Liquid Chromatography/Mass Spectrometry (LC/MS). Of 440 patients tested, 39 tested positive for Pregabalin (9.2%). Only 10 patients from this group were prescribed this drug to our knowledge thus giving an estimated rate of misuse of 7.0%. Other drugs detected in the Pregabalin positive patients were Opiates (31.8%), Cocaine (11.4%), Benzodiazepines (79.5%) and Cannabis (77.8%). Our study confirms that Pregabalin abuse is taking place amongst the addiction services population. We believe that misuse of this prescription drug is a serious emerging issue which should be monitored carefully.

  15. Mutagenesis analysis of the murine leukemia virus matrix protein: identification of regions important for membrane localization and intracellular transport.

    OpenAIRE

    Soneoka, Y; Kingsman, S M; Kingsman, A J

    1997-01-01

    We have created two sets of substitution mutations in the Moloney murine leukemia virus (Mo-MuLV) matrix protein in order to identify domains involved in association with the plasma membrane and in incorporation of the viral envelope glycoproteins into virus particles. The first set of mutations was targeted at putative membrane-associating regions similar to those of the human immunodeficiency virus type 1 matrix protein, which include a polybasic region at the N terminus of the Mo-MuLV matr...

  16. Hyperfine and magnetic properties of Fe-Cu clusters and Fe precipitates embedded in a Cu matrix

    Energy Technology Data Exchange (ETDEWEB)

    Klautau, A B [Faculdade de Fisica, Universidade Federal do Para, 66075-110, Belem, PA (Brazil); Socolovsky, L M [Laboratorio de Solidos Amorfos, INTECIN, Facultad de Ingenieria, Universidad de Buenos Aires, C1063ACV, Buenos Aires (Argentina); Nogueira, R N [Faculdade Taboao da Serra, 06768-000, Taboao da Serra, SP (Brazil); Petrilli, H M, E-mail: aklautau@ufpa.b [Instituto de Fisica, Universidade de Sao Paulo, CP 66318, 05315-970 Sao Paulo, SP (Brazil)

    2009-12-16

    Using the first-principles real-space linear muffin-tin orbital method within the atomic sphere approximation (RS-LMTO-ASA) we study hyperfine and local magnetic properties of substituted pure Fe and Fe-Cu clusters in an fcc Cu matrix. Spin and orbital contributions to magnetic moments, hyperfine fields and the Moessbauer isomer shifts at the Fe sites in Fe precipitates and Fe-Cu alloy clusters of sizes up to 60 Fe atoms embedded in the Cu matrix are calculated and the influence of the local environment on these properties is discussed.

  17. CFC substitutes. Substitute refrigerants and technologies in refrigeration engineering. Ersatzstoffe fuer FCKW. Ersatzkaeltemittel und Ersatztechnologien in der Kaeltetechnik

    Energy Technology Data Exchange (ETDEWEB)

    Hesse, U. (Forschungszentrum fuer Kaeltetechnik und Waermepumpen GmbH, Hannover (Germany)); Dietrich, K. (Bayer AG, Leverkusen (Germany)); Kauffeld, M.; Rinne, F. (Hannover Univ. (Germany). Inst. fuer Kaeltetechnik); Preisegger, E. (Hoechst AG, Frankfurt am Main (Germany)); Schwarz, J. (ZEO-TECH GmbH, Muenchen (Germany)); Kern, H.

    1992-01-01

    The CFC problem, i.e. ozone depletion and greenhouse effect, is the main problem in refrigeration engineering today. The ban on CFC has made it necessary to act, even before a general solution to the problem has been found. The book goes into detail on CFC substitutes development, testing, and application, as well as on alternative technologies and possible future developments. Safety aspects are considered for all materials and techniques. Contents: Fundamentals, development so far, restrictions - substitutes on the basis of partly halogenated hydrocarbons - ammonia as a substitute in refrigeration systems - safety aspects in the application of refrigerants and CFC substitutes - refrigerant mixtures as substitutes - sorption systems - cold air processes - further alternative substances and processes - future prospects. (orig.) With 125 figs., 108 refs.

  18. The Benefit of Currency Substitution during High Inflation and Stabilization The Benefit of Currency Substitution during High Inflation and Stabilization

    Directory of Open Access Journals (Sweden)

    Jacek Rostowski

    1992-03-01

    Full Text Available Allowing currency substitution in a very high inflation helps to maintain the level of output, as, the distortion of the information carried by prices is mitigated. The total (primary plus secondary money supply may increase if currency substitution is permitted. Currency substitution does not even necessarily reduce the real primary money stock. Moreover, the demand for the primary money fragments at very high rates of inflation, which means that the authorities may loose little when they give up the attempt to obtain inflation tax revenue. Currency substitution need be no more expensive, in term of the real resources it consumes, than is indexation. Finally the availability of a second stable currency may reduce the severity of post-stabilization recessions. The Benefit of Currency Substitution during High Inflation and Stabilization

  19. Random Matrix Theory and Econophysics

    Science.gov (United States)

    Rosenow, Bernd

    2000-03-01

    Random Matrix Theory (RMT) [1] is used in many branches of physics as a ``zero information hypothesis''. It describes generic behavior of different classes of systems, while deviations from its universal predictions allow to identify system specific properties. We use methods of RMT to analyze the cross-correlation matrix C of stock price changes [2] of the largest 1000 US companies. In addition to its scientific interest, the study of correlations between the returns of different stocks is also of practical relevance in quantifying the risk of a given stock portfolio. We find [3,4] that the statistics of most of the eigenvalues of the spectrum of C agree with the predictions of RMT, while there are deviations for some of the largest eigenvalues. We interpret these deviations as a system specific property, e.g. containing genuine information about correlations in the stock market. We demonstrate that C shares universal properties with the Gaussian orthogonal ensemble of random matrices. Furthermore, we analyze the eigenvectors of C through their inverse participation ratio and find eigenvectors with large ratios at both edges of the eigenvalue spectrum - a situation reminiscent of localization theory results. This work was done in collaboration with V. Plerou, P. Gopikrishnan, T. Guhr, L.A.N. Amaral, and H.E Stanley and is related to recent work of Laloux et al.. 1. T. Guhr, A. Müller Groeling, and H.A. Weidenmüller, ``Random Matrix Theories in Quantum Physics: Common Concepts'', Phys. Rep. 299, 190 (1998). 2. See, e.g. R.N. Mantegna and H.E. Stanley, Econophysics: Correlations and Complexity in Finance (Cambridge University Press, Cambridge, England, 1999). 3. V. Plerou, P. Gopikrishnan, B. Rosenow, L.A.N. Amaral, and H.E. Stanley, ``Universal and Nonuniversal Properties of Cross Correlations in Financial Time Series'', Phys. Rev. Lett. 83, 1471 (1999). 4. V. Plerou, P. Gopikrishnan, T. Guhr, B. Rosenow, L.A.N. Amaral, and H.E. Stanley, ``Random Matrix Theory

  20. Matrix Completion from Noisy Entries

    CERN Document Server

    Keshavan, Raghunandan H; Oh, Sewoong

    2009-01-01

    Given a matrix M of low-rank, we consider the problem of reconstructing it from noisy observations of a small, random subset of its entries. The problem arises in a variety of applications, from collaborative filtering (the `Netflix problem') to structure-from-motion and positioning. We study a low complexity algorithm introduced by Keshavan et al.(2009), based on a combination of spectral techniques and manifold optimization, that we call here OptSpace. We prove performance guarantees that are order-optimal in a number of circumstances.

  1. Effect of storage temperature on self-irradiation damage of 238Pu-substituted zirconolite

    International Nuclear Information System (INIS)

    238Pu-substituted cubic zirconolite (CaPuTi2O7) was stored at ambient temperature, 5750 K, and 8750 K until alpha decay doses of 2.4 to 3.6 x 1025/m3 had been accumulated. The ambient temperature material swelled to a saturation value of 5.5 vol %, and the originally crystalline structure was transformed to one with an amorphous matrix and small domains that had retained their crystallinity. At 5750 K, lesser amounts of swelling (4.1 vol %) and transformation were observed, reflecting concurrent partial recovery. The material held at 8750 K remained crystalline, swelled only 0.4 vol %, and exhibited formation of isolated defect clusters. 5 figures

  2. Thin wall ductile iron casting as a substitute for aluminum alloy casting in automotive industry

    Directory of Open Access Journals (Sweden)

    M. Górny

    2009-01-01

    Full Text Available In paper it is presented thin wall ductile iron casting (TWDI as a substitute of aluminium alloy casting. Upper control arm made of ductile iron with wall thickness ranging from 2 – 3.7 mm was produced by inmold process. Structure, mechanical properties and computer simulations were investigated. Structural analysis of TWDI shows pearlitic-ferritic matrix free from chills and porosity. Mechanical testing disclose superior ultimate tensile strength (Rm, yield strength (Rp0,2 and slightly lower elongation (E of TWDI in comparison with forged control arm made of aluminium alloy (6061-T6. Moreover results of computer simulation of static loading for tested control arms are presented. Analysis show that the light-weight ductile iron casting can be loaded to similar working conditions as the forged Al alloy without any potential failures.

  3. Experimental and theoretical spectroscopic and structural study of A-ring substituted camptothecins

    Science.gov (United States)

    Ivanova, Bojidarka B.; Spiteller, Michael

    2012-03-01

    The molecular architecture design and physical properties of seven camptothecin (CPT) alkaloids, structurally related to irinotecan (CPT-11), substituted with the cyclic bulk N-aliphatic substituents at A-ring as well as their different protonated forms were studied. The correlation between the molecular geometry and physical properties of the neutral lactone form and different possible cationic forms was elucidated, using the electronic absorptions (EAs), circular dichroic (CD) and Raman spectroscopy within the far-IR region as well as electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry and nuclear magnetic resonance methods. The electronic structures, and properties of the neutral CPTs, their mono- and diprotonated forms as well as molecular ion fragments, obtained by the mass spectrometric data are predicted theoretically using the DFT method.

  4. Minimal solution for inconsistent singular fuzzy matrix equations

    OpenAIRE

    M. Nikuie; M. K. Mirnia

    2013-01-01

    The fuzzy matrix equations $Ailde{X}=ilde{Y}$ is called a singular fuzzy matrix equations while the coefficients matrix of its equivalent crisp matrix equations be a singular matrix. The singular fuzzy matrix equations are divided into two parts: consistent singular matrix equations and inconsistent fuzzy matrix equations. In this paper, the inconsistent singular fuzzy matrix equations is studied and the effect of generalized inverses in finding minimal solution of an inconsistent singular fu...

  5. Fuzzy Symmetric Solutions of Fuzzy Matrix Equations

    OpenAIRE

    Xiaobin Guo; Dequan Shang

    2012-01-01

    The fuzzy symmetric solution of fuzzy matrix equation AX˜=B˜, in which A is a crisp m×m nonsingular matrix and B˜ is an m×n fuzzy numbers matrix with nonzero spreads, is investigated. The fuzzy matrix equation is converted to a fuzzy system of linear equations according to the Kronecker product of matrices. From solving the fuzzy linear system, three types of fuzzy symmetric solutions of the fuzzy matrix equation are derived. Finally, two examples are given to illustrate the proposed method....

  6. Linear algebra and matrix analysis for statistics

    CERN Document Server

    Banerjee, Sudipto

    2014-01-01

    Matrices, Vectors, and Their OperationsBasic definitions and notations Matrix addition and scalar-matrix multiplication Matrix multiplication Partitioned matricesThe ""trace"" of a square matrix Some special matricesSystems of Linear EquationsIntroduction Gaussian elimination Gauss-Jordan elimination Elementary matrices Homogeneous linear systems The inverse of a matrixMore on Linear EquationsThe LU decompositionCrout's Algorithm LU decomposition with row interchanges The LDU and Cholesky factorizations Inverse of partitioned matrices The LDU decomposition for partitioned matricesThe Sherman-W

  7. MatrixPlot: visualizing sequence constraints

    DEFF Research Database (Denmark)

    Gorodkin, Jan; Stærfeldt, Hans Henrik; Lund, Ole;

    1999-01-01

    MatrixPlot: visualizing sequence constraints. Sub-title Abstract Summary : MatrixPlot is a program for making high-quality matrix plots, such as mutual information plots of sequence alignments and distance matrices of sequences with known three-dimensional coordinates. The user can add information...... about the sequences (e.g. a sequence logo profile) along the edges of the plot, as well as zoom in on any region in the plot. Availability : MatrixPlot can be obtained on request, and can also be accessed online at http://www. cbs.dtu.dk/services/MatrixPlot. Contact : gorodkin@cbs.dtu.dk...

  8. Fragmentation of extracellular matrix by hypochlorous acid

    DEFF Research Database (Denmark)

    Woods, Alan A; Davies, Michael Jonathan

    2003-01-01

    of the MPO-derived oxidant hypochlorous acid (HOCl) with extracellular matrix from vascular smooth muscle cells and healthy pig arteries has been examined. HOCl is rapidly consumed by such matrix samples, with the formation of matrix-derived chloramines or chloramides. The yield of these intermediates...... increases with HOCl dose. These materials undergo a time- and temperature-dependent decay, which parallels the release of sugar and protein components from the treated matrix, consistent with these species being important intermediates. Matrix damage is enhanced by species that increase chloramine...

  9. Singular Value Decomposition for Unitary Symmetric Matrix

    Institute of Scientific and Technical Information of China (English)

    ZOUHongxing; WANGDianjun; DAIQionghai; LIYanda

    2003-01-01

    A special architecture called unitary sym-metric matrix which embodies orthogonal, Givens, House-holder, permutation, and row (or column) symmetric ma-trices as its special cases, is proposed, and a precise corre-spondence of singular values and singular vectors between the unitary symmetric matrix and its mother matrix is de-rived. As an illustration of potential, it is shown that, for a class of unitary symmetric matrices, the singular value decomposition (SVD) using the mother matrix rather than the unitary symmetric matrix per se can save dramatically the CPU time and memory without loss of any numerical precision.

  10. Ex vivo and in vivo modulatory effects of umbilical cord Wharton's jelly stem cells on human oral mucosa stroma substitutes.

    Science.gov (United States)

    Alfonso-Rodríguez, C A; González-Andrades, E; Jaimes-Parra, B D; Fernández-Valadés, R; Campos, A; Sánchez-Quevedo, M C; Alaminos, M; Garzón, I

    2015-11-01

    Novel oral mucosa substitutes have been developed in the laboratory using human umbilical cord Wharton's jelly stem cells -HWJSC- as an alternative cell source. In the present work, we have generated human oral mucosa substitutes with oral mucosa keratinocytes and HWJSC to determine the influence of these cell sources on stromal differentiation. First, acellular and cellular stroma substitutes and bilayered oral mucosa substitutes with an epithelial layer consisting of oral mucosa keratinocytes -OM samples- or HWJSC -hOM- were generated. Then, tissues were analyzed by light and electron microscopy, histochemistry and immunohistochemistry to quantify all major extracellular matrix components after 1, 2 and 3 weeks of ex vivo development, and OM and hOM were also analyzed after in vivo grafting. The results showed that bioengineered oral mucosa stromas displayed an adequate fibrillar mesh. Synthesis of abundant collagen fibers was detected in OM and hOM after 3 weeks, and in vivo grafting resulted in an increased collagen synthesis. No elastic or reticular fibers were found. Glycoprotein synthesis was found at the epithelial-stromal layer when samples were grafted in vivo. Finally, proteoglycans, decorin, versican and aggrecan were strongly dependent on the in vivo environment and the presence of a well-structured epithelium on top. The use of HWJSC was associated to an increased synthesis of versican. These results confirm the usefulness of fibrin-agarose biomaterials for the generation of an efficient human oral mucosa stroma substitute and the importance of the in vivo environment and the epithelial-mesenchymal interaction for the adequate differentiation of the bioengineered stroma.

  11. A facile fabrication of porous PMMA as a potential bone substitute

    Energy Technology Data Exchange (ETDEWEB)

    Han Jing; Ma Guiping [State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029 (China); Nie Jun, E-mail: niejun@mail.buct.edu.cn [State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029 (China); College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072 (China)

    2011-10-10

    This study is aimed to develop porous poly(methyl methacrylate) (PMMA) as a potential bone substitute via a facile fabrication method. Composites consisting of water-soluble chitosan oligosaccharide (CSO) and PMMA were prepared by combining freeze-drying with radical polymerization. Open porous PMMA with controlled porosities were obtained after the CSO was extracted gradually from the composites. The CSO aqueous solutions with different concentrations were frozen and then freeze-dried to obtain interconnected porous framework. Methyl methacrylate with initiators and a crosslink agent was introduced into the porous framework and polymerized, resulting in two-continuous phase composites. The mechanical properties of the initial composites and porous materials after immersion in PBS for 8 weeks were investigated. Dynamic mechanical analysis was conducted to study the mechanical strength of the composite, compared with bulk PMMA. Porosity and morphology of porous PMMA were studied using the liquid displacement method and scanning electron microscopy, respectively. Thermogravimetric analysis indicated that composite exhibited better thermal stability than bulk PMMA. The composites became porous materials after extracting bioactive CSO component. The mechanical properties of porous materials were closer to those of cancellous bone. The generation of pores using CSO seems to be a promising method to prepare porous PMMA as a potential bone substitute. - Research Highlights: {yields} Chitosan oligosaccharide (CSO) /poly(methyl methacrylate) composites was fabricated. {yields} The composites became interconnected porous PMMA after CSO was dissolved. {yields} The introduction of CSO could modulate the properties of PMMA matrix. {yields} The generation of pores using CSO is a facile method to obtain porous PMMA. {yields} The porous PMMA has potential in biomedical field as a bone substitute.

  12. The Human Umbilical Cord: A Novel Substitute for Reconstruction of the Extrahepatic Bile Duct

    Directory of Open Access Journals (Sweden)

    Jiong Lu

    2012-01-01

    Full Text Available Reconstruction of the extrahepatic bile duct following bile duct injury or defect is one of the most common challenges for hepatobiliary surgeons. There are currently a number of surgical strategies such as biliary-enteric anastomosis, end-to-end anastomosis and autologous tissue substitute. However, sphincter of Oddi dysfunction as well as biliary stricture may occur after surgical anastomosis. Also, insufficient tissue quantity remains a problem associated with the application of tissue substitute. Therefore, considerable attention has been attracted to explore a new replacement material of the bile duct for biliary reconstruction. The human umbilical cord (HUC is abundant in resource and is convenient to collect, including two arteries and one vein, whose diameters are close to that of the common bile duct. In order to reduce immunogenicity (foreign-body reaction, cells and major histocompatibility complex (MHC antigens can be removed from the HUC and the remaining tissue (extracellular matrix, ECM can be used as a scaffold. The HUC provides a rich source of mesenchymal stem cells (MSCs. A current study has demonstrated that MSCs are able to differentiate into biliary epithelial cells in vivo and in vitro with low immunogenicity, which can be used as seed cells. The HUC might be a promising composite material of a scaffold (ECM and seed cells (biliary epithelial cells, for bile duct replacement in situ without removal of sphincter of Oddi, or biliary stricture. In addition, the patients’ own umbilical cord without any foreign-body reaction can be directly banked for possible future use in bile duct reconstruction. Therefore, we hypothesise that the HUC may be a novel substitute for reconstruction of the extrahepatic bile duct.

  13. The radiological properties of a novel lung tissue substitute.

    Science.gov (United States)

    Traub, R J; Olsen, P C; McDonald, J C

    2006-01-01

    Lung phantoms have been manufactured using commercially available, polyurethane foam products. Some of these materials are no longer available; therefore, a new lung tissue substitute was developed. The elemental composition and radiological properties of the new lung tissue substitute are described in this paper. Because the lung tissue substitute will be used to manufacture phantom lungs that will be used to evaluate chest counting systems, it is necessary to know the radiological properties of the material. These properties must be compared with reference materials and materials that have been used for lung phantoms in the past. The radiological properties of interest include the electron density, mean excitation energy, electron stopping power and photon mass attenuation coefficients. In all these properties, the calculated values for the new lung tissue substitute closely matched the calculated values of ICRU Publication 44 lung tissue. Good agreement was also found when the new lung tissue substitute was compared with the Griffith lung tissue substitute described by the ICRU. The new material was determined to be an excellent lung tissue substitute. PMID:17142822

  14. Hotspots of biased nucleotide substitutions in human genes.

    Directory of Open Access Journals (Sweden)

    Jonas Berglund

    2009-01-01

    Full Text Available Genes that have experienced accelerated evolutionary rates on the human lineage during recent evolution are candidates for involvement in human-specific adaptations. To determine the forces that cause increased evolutionary rates in certain genes, we analyzed alignments of 10,238 human genes to their orthologues in chimpanzee and macaque. Using a likelihood ratio test, we identified protein-coding sequences with an accelerated rate of base substitutions along the human lineage. Exons evolving at a fast rate in humans have a significant tendency to contain clusters of AT-to-GC (weak-to-strong biased substitutions. This pattern is also observed in noncoding sequence flanking rapidly evolving exons. Accelerated exons occur in regions with elevated male recombination rates and exhibit an excess of nonsynonymous substitutions relative to the genomic average. We next analyzed genes with significantly elevated ratios of nonsynonymous to synonymous rates of base substitution (dN/dS along the human lineage, and those with an excess of amino acid replacement substitutions relative to human polymorphism. These genes also show evidence of clusters of weak-to-strong biased substitutions. These findings indicate that a recombination-associated process, such as biased gene conversion (BGC, is driving fixation of GC alleles in the human genome. This process can lead to accelerated evolution in coding sequences and excess amino acid replacement substitutions, thereby generating significant results for tests of positive selection.

  15. Structure and Infrared Radiation Properties of Substituted Cordierites

    Institute of Scientific and Technical Information of China (English)

    XU Qing; SONG Chaowen; CHEN Wen; LIU Xiaofang; ZHANG Feng

    2006-01-01

    Zn2+ - or Ti4+ -substituted cordierites with the nominal compositions of Mg1.6 Zn0.4 Al4 Si5 O18 and Mg1.8 Ti0.2 Al4.4 Si4.6 O18 respectively, were prepared by a conventional solid state reaction method. The structure of the substituted cordierites was characterized by X- ray diffraction (XRD), infrared ( IR ) spectroscopy and 29 Si magic angle spinning ( MAS ) nuclear magnetic resonance ( NMR ). The infrared radiation properties were investigated in the bands within 2.5-25 μm. Compared with the un-substituted cordierite composition ( Mg2 Al4 Si5 O18 ), Zn2+ - or Ti4+ -substituted cordierites show superior infrared properties . XRD and IR results confirm the formation of hexagonal α-cordierite as the main crystal phase for the substituted cordierites. 29 Si MAS NMR result indicates that Zn2+ or Ti4+ substitutions for partial Mg2+ of a- cordierite promoted the ordering of the distribution of Al and Si atoms in T1 ( tetrahedra connecting six-membered rings together with [ MgO6 ] octahedra ) and T2 ( tetraheda forming six- membered rings ) tetrahedral sites. This resulted in a lattice deformation and increased the anharmonicity of polarization vibration, which is responsible for the improvement of infrared radiation properties of the substituted cordierites.

  16. The role of biomass in US industrial interfuel substitution

    International Nuclear Information System (INIS)

    The role of biomass in US industrial interfuel substitution in the industrial sector has typically been analyzed using data for the four traditional fuels of coal, oil, electricity and natural gas. However, the use of biomass as an industrial fuel in the US has grown, and now exceeds that of coal. Using data from 1960 to 2011, interfuel substitution in the US industrial sector is modeled with a dynamic linear logit model which includes biomass alongside the other four traditional fuels. Adding biomass to the model reduces somewhat the estimated own-price and cross-price elasticities for the other four fuels, while revealing that biomass and natural gas are substitute fuels. This implies that previous studies excluding biomass may have overestimated the potential for interfuel substitution, giving policy makers an inaccurate impression of the ability of carbon taxes or other environmental regulation to reduce greenhouse gas (GHG) emissions. - Highlights: • Biomass usage by the US industrial sector now exceeds coal usage. • Previous interfuel substitution studies have not included biomass as a fuel. • Linear logit model is used to examine role of biomass in interfuel substitution. • Including biomass in the model lowers estimated price elasticities for traditional fuels. • Biomass is found to be a substitute for natural gas for industrial users

  17. The radiological properties of a novel lung tissue substitute

    International Nuclear Information System (INIS)

    Lung phantoms have been manufactured using commercially available, polyurethane foam products. Some of these materials are no longer available; therefore, a new lung tissue substitute was developed. The elemental composition and radiological properties of the new lung tissue substitute are described in this paper. Because the lung tissue substitute will be used to manufacture phantom lungs that will be used to evaluate chest counting systems, it is necessary to know the radiological properties of the material. These properties must be compared with reference materials and materials that have been used for lung phantoms in the past. The radiological properties of interest include the electron density, mean excitation energy, electron stopping power and photon mass attenuation coefficients. In all these properties, the calculated values for the new lung tissue substitute closely matched the calculated values of ICRU Publication 44 lung tissue. Good agreement was also found when the new lung tissue substitute was compared with the Griffith lung tissue substitute described by the ICRU. The new material was determined to be an excellent lung tissue substitute. (authors)

  18. Sparse Matrix Inversion with Scaled Lasso

    CERN Document Server

    Sun, Tingni

    2012-01-01

    We propose a new method of learning a sparse nonnegative-definite target matrix. Our primary example of the target matrix is the inverse of a population covariance matrix or correlation matrix. The algorithm first estimates each column of the matrix by scaled Lasso, a joint estimation of regression coefficients and noise level, and then adjusts the matrix estimator to be symmetric. The procedure is efficient in the sense that the penalty level of the scaled Lasso for each column is completely determined by the data via convex minimization, without using cross-validation. We prove that this method guarantees the fastest proven rate of convergence in the spectrum norm under conditions of weaker form than those in the existing analyses of other $\\ell_1$ algorithms, and has faster guaranteed rate of convergence when the ratio of the $\\ell_1$ and spectrum norms of the target inverse matrix diverges to infinity. A simulation study also demonstrates the competitive performance of the proposed estimator.

  19. Effect of substitution of sand stone dust for quartz and clay in triaxial porcelain composition

    Indian Academy of Sciences (India)

    M K Haldar; S K Das

    2012-10-01

    Quartz and kaolin were partially substituted by sand stone dust (a siliceous byproduct of Indian stone cutting and polishing industries) in a traditional triaxial porcelain composition consisting of kaolin, quartz and feldsper. The effect of substitution upon heating at different temperatures (1050–1150°C) were studied by measuring the linear shrinkage, bulk density, porosity and flexural strength. Qualititative phase and microstructural analysis on selected samples were carried out using XRD and SEM/EDX technique. The results show that the samples of all the batches achieved higher density (2.50 g/cc) and almost full vitrification (<0.1% apparent porosity) at around 1115°C compared to around 1300°C for traditional triaxial porcelain composition. As high as 70 MPa flexural strength was obtained in most of the vitrified samples. No significant variation in physico-mechanical properties was observed in between the composition. XRD studies on selected samples show presence of mainly quartz phase both at low and high temperatures. SEM photomicrographs of the 1115°C heated specimen show presence of quartz grain and glassy matrix. Few quartz grains (20–40m) are associated with circumferential cracks around them.

  20. Effect of saccades in tongue electrotactile stimulation for vision substitution applications

    CERN Document Server

    Chekhchoukh, Abdessalem; Payan, Yohan; Glade, Nicolas

    2013-01-01

    The visual substitution paradigm aims to facilitate the life of blind people. Generally one uses electro-stimulating devices where electrodes are arranged into arrays to stimulate the skin or the tongue mucosa to send signals of visual type to the subjects. When an electro-stimulation signal is applied continuously (e.g. when static visual scenes are displayed for a long period of time), the receptors of the affected region can get saturated and the patient may lose the displayed information. We propose here some mechanisms that ameliorate the quality of perception of the electro-stimulation information. The electrical signal is encoded as 2D scenes projected onto the tongue via a Tongue Display Unit, i.e. an electro-tactile stimulator formed by a 12x12 matrix of electrodes. We propose to apply stochastic saccades on this signal. Our assumption is that this eye-inspired mechanism should make the visual substitution more efficient (by improving the perception) because of the reduction of the tactile receptors ...

  1. Interpolation of rational matrix functions

    CERN Document Server

    Ball, Joseph A; Rodman, Leiba

    1990-01-01

    This book aims to present the theory of interpolation for rational matrix functions as a recently matured independent mathematical subject with its own problems, methods and applications. The authors decided to start working on this book during the regional CBMS conference in Lincoln, Nebraska organized by F. Gilfeather and D. Larson. The principal lecturer, J. William Helton, presented ten lectures on operator and systems theory and the interplay between them. The conference was very stimulating and helped us to decide that the time was ripe for a book on interpolation for matrix valued functions (both rational and non-rational). When the work started and the first partial draft of the book was ready it became clear that the topic is vast and that the rational case by itself with its applications is already enough material for an interesting book. In the process of writing the book, methods for the rational case were developed and refined. As a result we are now able to present the rational case as an indepe...

  2. Substitute natural gas from biomass gasification

    Energy Technology Data Exchange (ETDEWEB)

    Tunaa, Per (Lund Inst. of Technology, Lund (SE))

    2008-03-15

    Biomass is by many considered as the only alternative to phase-out the usage of fossil fuels such as natural gas and oil especially for the transportation sector where alternative solutions, such as hydrogen fuel cells and batteries, are not yet fully developed. Thermal gasification or other methods such as pyrolysis of the biomass must be applied in order to produce an intermediate product suitable for further upgrading to either gaseous or liquid products. This thesis will evaluate the possibilities of producing, substitute natural gas, (SNG) from biomass gasification by using computer simulation. Three different gasification techniques were evaluated; entrained-flow, fluidized-bed and indirect gasification coupled with two different desulphurisation systems and two methanation processes. The desulphurisation systems were a zinc oxide bed and a Rectisol wash system. Methanation were performed by a series of adiabatic reactors with gas recycling and by an isothermal reactor. The impact on SNG efficiency from system pressure, isothermal methanation temperature and PSA methane recovery were evaluated as well. The results show that the fluidized-bed and the indirect gasifier have the highest SNG efficiency. Furthermore there are little to no difference between the methanation processes and small differences for the gas cleanup systems. SNG efficiencies in excess of 50 % were possible for all gasifiers. SNG efficiency is defined as the energy in the SNG product divided by the total input to the system from biomass, drying and oxygen. Increasing system pressure has a negative impact on SNG efficiency as well as increasing operating costs due to increased power for compression. Isothermal methanation temperature has no significant impact on SNG efficiency. Recovering as much methane as possible in the PSA is the most important parameter. Recovering methane that has been dissolved in condensed process water increases the SNG efficiency by 2-10% depending on system.

  3. [Breast milk substitutes based on cow milk].

    Science.gov (United States)

    Kofoed, P E

    1990-08-20

    "Adapted" or "humanized" breast-milk substitutes based on cows' milk are manufactured according to directives from a publication issued by the Ministry of Agriculture. The accepted recommendations for the daily intake (RDA) of nutrients is adjusted to the neonates' relatively low tolerance and provides a certain margin of safety in case of illness and slight inaccuracies in preparation. The recommendations are, however, often based on animal experiments, studies of pathological conditions etc. because the needs of the neonate are not known. There is a fundamental difference between RDA for chemical energy and various nutrients as the energy requirement is stated on the basis of average values while the requirements for specific nutrients are gives as upper and lower limiting values. In addition to nutrients, a long series of hormones, enzymes and antimicrobial factors are transferred to the infant via breast-milk. The nutritional significance of these is entirely or partially unknown. It is thus impossible to give the bottle-fed infant a diet which is quantitatively and qualitatively identical with that of a breastfed baby. Nevertheless, experience has shown that bottle-feeding usually proceeds satisfactorily. Galactosaemia and certain forms of medication in the mother constitute absolute contraindications to breast-feeding while phenylketonuria, certain maternal infections are relative contraindications to breast-feeding. Mothers should be prepared for breast-feeding already during pregnancy but in the cases where the mother cannot, should not or does not wish to breast-feed, it is important to counteract any feelings of guilt, neglect or incompetence and, on the other hand, give her thorough training in artificial feeding of the infant. PMID:2205958

  4. Elasticity of substitution and anti-dumping decisions

    DEFF Research Database (Denmark)

    Hansen, Jørgen Drud; Meinen, Philipp; Nielsen, Jørgen Ulff-Møller

    2014-01-01

    Motivated by a monopolistic competition model with market segmentation and international price discrimination, this paper analyzes whether there is an inverse relation between the elasticity of substitution and final ad valorem anti-dumping duties across products. We test this for 19 countries...... using data on anti-dumping from the Global Antidumping Database and US data at the 6-digit HS product level for the elasticity of substitution from Broda and Weinstein (Q J Econ 121(2):541–585, 2006). The results in our empirical investigation support a negative relation between the elasticity...... of substitution and the final ad valorem anti-dumping duties....

  5. Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats

    Directory of Open Access Journals (Sweden)

    Abu Bakar Mohd Hilmi

    2013-01-01

    Full Text Available Wounds with full-thickness skin loss are commonly managed by skin grafting. In the absence of a graft, reepithelialization is imperfect and leads to increased scar formation. Biomaterials can alter wound healing so that it produces more regenerative tissue and fewer scars. This current study use the new chitosan based biomaterial in full-thickness wound with impaired healing on rat model. Wounds were evaluated after being treated with a chitosan dermal substitute, a chitosan skin substitute, or duoderm CGF. Wounds treated with the chitosan skin substitute showed the most re-epithelialization (33.2 ± 2.8%, longest epithelial tongue (1.62 ± 0.13 mm, and shortest migratory tongue distance (7.11 ± 0.25 mm. The scar size of wounds treated with the chitosan dermal substitute (0.13 ± 0.02 cm and chitosan skin substitute (0.16 ± 0.05 cm were significantly decreased (P<0.05 compared with duoderm (0.45 ± 0.11 cm. Human leukocyte antigen (HLA expression on days 7, 14, and 21 revealed the presence of human hair follicle stem cells and fibroblasts that were incorporated into and surviving in the irradiated wound. We have proven that a chitosan dermal substitute and chitosan skin substitute are suitable for wound healing in full-thickness wounds that are impaired due to radiation.

  6. Intermetallic bonded ceramic matrix composites

    Energy Technology Data Exchange (ETDEWEB)

    Plucknett, K.P.; Tiegs, T.N.; Alexander, K.B.; Becher, P.F.; Schneibel, J.H.; Waters, S.B.; Menchhofer, P.A. [Oak Ridge National Lab., TN (United States). Metals and Ceramics Div.

    1995-07-01

    A range of carbide and oxide-based cermets have been developed utilizing ductile nickel aluminide (Ni{sub 3}Al) alloy binder phases. Some of these, notably materials based upon tungsten and titanium carbides (WC and TiC respectively), offer potential as alternatives to the cermets which use cobalt binders (i.e. WC/Co). Samples have been prepared by blending commercially available Ni{sub 3}Al alloy powders with the desired ceramic phases, followed by hot-pressing. Alumina (Al{sub 2}O{sub 3}) matrix materials have also been prepared by pressurized molten alloy infiltration. The microstructure, flexure strength and fracture toughness of selected materials are discussed.

  7. The Biblical Matrix of Economics

    Directory of Open Access Journals (Sweden)

    Grigore PIROŞCĂ

    2012-05-01

    Full Text Available The rationale of this paper is a prime pattern of history of economic thought in the previous ages of classic ancient times of Greek and Roman civilizations using a methodological matrix able to capture the mainstream ideas from social, political and religious events within the pages of Bible. The economic perspective of these events follows the evolution of the seeds of economic thinking within the Fertile Crescent, focused on the Biblical patriarchic heroes’ actions, but also on the empires which their civilization interacted to. The paper aims to discover the path followed by the economic doctrines from the Bible in order to find a match with economic actuality of present days.

  8. Industrialization in Sub-Saharan Africa and import substitution policy

    Directory of Open Access Journals (Sweden)

    Ana Paula F. Mendes

    2014-03-01

    Full Text Available This article aims to contribute to the understanding of the process of import substitution in Sub-Saharan Africa. The process of industrialization in Sub-Saharan Africa occurred in two phases: a first step, even very early during the colonial regime began around the 1920s and ended in the late forties; a second phase of industrialization began in the late fifties and gained momentum in the sixties, when import substitution was implemented more widely. Although these countries were the last to embark on the strategy of import substitution, they followed the same steps of Latin American countries, and as the structural domestic and external constraints were too strong, the failure of the policy of import substitution arrived early and the negative impact on these economies had a greater magnitude.

  9. 38 CFR 36.4287 - Substitution of trustees.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) LOAN GUARANTY Guaranty of Loans to Veterans to Purchase Manufactured Homes and Lots, Including... appoint substitute trustees or other person with such power to sell, who shall succeed to all the...

  10. Substitution possibilities and determinants of energy intensity for China

    International Nuclear Information System (INIS)

    This paper measures technological change, factor demand and inter-factor and inter-fuel substitutability measures for China. We use individual fuel price data and a two-stage approach to estimate total factor cost functions and fuel share equations. Both inter-factor and inter-fuel substitution elasticities are calculated and the change in energy intensity is decomposed into its driving forces. The results suggest that energy is substitutable for capital regionally and for labor nationally. Capital substitutes for energy more easily than labor does. Energy intensity changes vary by region but the major drivers seem to be 'budget effect' and the adoption of energy-intensive technologies, which might be embodied in high-level energy-using exports and sectors, capital investment and even old technique and equipment imports. Whether the trend in rising energy intensity continues will be significant for China and the rest of the world.

  11. Substitution possibilities and determinants of energy intensity for China

    International Nuclear Information System (INIS)

    This paper measures technological change, factor demand and inter-factor and inter-fuel substitutability measures for China. We use individual fuel price data and a two-stage approach to estimate total factor cost functions and fuel share equations. Both inter-factor and inter-fuel substitution elasticities are calculated and the change in energy intensity is decomposed into its driving forces. The results suggest that energy is substitutable for capital regionally and for labor nationally. Capital substitutes for energy more easily than labor does. Energy intensity changes vary by region but the major drivers seem to be 'budget effect' and the adoption of energy-intensive technologies, which might be embodied in high-level energy-using exports and sectors, capital investment and even old technique and equipment imports. Whether the trend in rising energy intensity continues will be significant for China and the rest of the world. (author)

  12. Factors Affecting the Form of Substitute Family Care

    Directory of Open Access Journals (Sweden)

    Monika Chrenková

    2015-11-01

    Full Text Available Recently, the system of care for endangered children has changed from the institutional as well as legislative point of view. In one of the partial areas of ongoing changes, research activities realised within the Students’ Grant Competition called The Factors Affecting the Form of Substitute Family Care are being focused. We deal with this topic because various forms of substitute family care are distinguished in the Czech Republic, where children are placed for various reasons, but we do not know the correct context of such placements. The main aim of the realised research was to find out the frequency of choosing a given form of placing children in substitute family care according to followed variables. The research sample of the quantitative research was consisted of children placed in one of the forms of substitute family care in the Moravian-Silesian region.

  13. Synthesis of library from amino-hydroxy substituted cyclopentanes

    DEFF Research Database (Denmark)

    Bøjstrup, Marie; Lundt, Inge; Andrews, Robert

    Based on radical induced carbocyclisation of unsaturated aldonolactones our group has elaborated procedures for the preparation of several amino-hydroxy substituted cyclopentane derivatives [1]. These highly functionalized molecules are suitable for attachment to solid phase and subsequent parall...

  14. Associations between generic substitution and patients' attitudes, beliefs and experience

    DEFF Research Database (Denmark)

    Østergaard Rathe, Jette; Larsen, Pia Veldt; Andersen, Morten;

    2013-01-01

    Abstract Background Generic substitution has been implemented in many countries, but knowledge about patients’ attitudes, beliefs and experiences is still sparse. Aim To assess associations between generic switching and patients’ attitudes, beliefs and experiences with previous generic switching....

  15. Multiple Base Substitution Corrections in DNA Sequence Evolution

    Science.gov (United States)

    Kowalczuk, M.; Mackiewicz, P.; Szczepanik, D.; Nowicka, A.; Dudkiewicz, M.; Dudek, M. R.; Cebrat, S.

    We discuss the Jukes and Cantor's one-parameter model and Kimura's two-parameter model unability to describe evolution of asymmetric DNA molecules. The standard distance measure between two DNA sequences, which is the number of substitutions per site, should include the effect of multiple base substitutions separately for each type of the base. Otherwise, the respective tables of substitutions cannot reconstruct the asymmetric DNA molecule with respect to the composition. Basing on Kimura's neutral theory, we have derived a linear law for the correlation of the mean survival time of nucleotides under constant mutation pressure and their fraction in the genome. According to the law, the corrections to Kimura's theory have been discussed to describe evolution of genomes with asymmetric nucleotide composition. We consider the particular case of the strongly asymmetric Borrelia burgdorferi genome and we discuss in detail the corrections, which should be introduced into the distance measure between two DNA sequences to include multiple base substitutions.

  16. Reduction of magnetic interlayer coupling in barlowite through isoelectronic substitution

    Science.gov (United States)

    Guterding, Daniel; Valentí, Roser; Jeschke, Harald O.

    2016-09-01

    Materials with a perfect kagome lattice structure of magnetic ions are intensively sought after, because they may exhibit exotic ground states like a quantum spin liquid phase. Barlowite is a natural mineral that features perfect kagome layers of copper ions. However, in barlowite there are also copper ions between the kagome layers, which mediate strong interkagome couplings and lead to an ordered ground state. Using ab initio density functional theory calculations we investigate whether selective isoelectronic substitution of the interlayer copper ions is feasible. After identifying several promising candidates for substitution we calculate the magnetic exchange couplings based on crystal structures predicted from first-principles calculations. We find that isoelectronic substitution with nonmagnetic ions significantly reduces the interkagome exchange coupling. As a consequence, interlayer-substituted barlowite can be described by a simple two-parameter Heisenberg Hamiltonian, for which a quantum spin liquid ground state has been predicted.

  17. Substitution possibilities and determinants of energy intensity for China

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Hengyun [College of Economics and Management, Henan Agricultural University, 95 Wenhua Road, Zhengzhou 450002 (China); Department of Economics, University of Canterbury, Private bag 4800, Christchurch 8140 (New Zealand); Oxley, Les [Department of Economics, University of Canterbury, Private bag 4800, Christchurch 8140 (New Zealand); Gibson, John [Department of Economics, University of Waikato, Private Bag 3105, Hamilton (New Zealand)

    2009-05-15

    This paper measures technological change, factor demand and inter-factor and inter-fuel substitutability measures for China. We use individual fuel price data and a two-stage approach to estimate total factor cost functions and fuel share equations. Both inter-factor and inter-fuel substitution elasticities are calculated and the change in energy intensity is decomposed into its driving forces. The results suggest that energy is substitutable for capital regionally and for labor nationally. Capital substitutes for energy more easily than labor does. Energy intensity changes vary by region but the major drivers seem to be 'budget effect' and the adoption of energy-intensive technologies, which might be embodied in high-level energy-using exports and sectors, capital investment and even old technique and equipment imports. Whether the trend in rising energy intensity continues will be significant for China and the rest of the world. (author)

  18. Substitution possibilities and determinants of energy intensity for China

    Energy Technology Data Exchange (ETDEWEB)

    Ma Hengyun [College of Economics and Management, Henan Agricultural University, 95 Wenhua Road, Zhengzhou 450002 (China) and Department of Economics, University of Canterbury, Private bag 4800, Christchurch 8140 (New Zealand)], E-mail: h.y.ma@163.com; Oxley, Les [Department of Economics, University of Canterbury, Private bag 4800, Christchurch 8140 (New Zealand); Gibson, John [Department of Economics, University of Waikato, Private Bag 3105, Hamilton (New Zealand)

    2009-05-15

    This paper measures technological change, factor demand and inter-factor and inter-fuel substitutability measures for China. We use individual fuel price data and a two-stage approach to estimate total factor cost functions and fuel share equations. Both inter-factor and inter-fuel substitution elasticities are calculated and the change in energy intensity is decomposed into its driving forces. The results suggest that energy is substitutable for capital regionally and for labor nationally. Capital substitutes for energy more easily than labor does. Energy intensity changes vary by region but the major drivers seem to be 'budget effect' and the adoption of energy-intensive technologies, which might be embodied in high-level energy-using exports and sectors, capital investment and even old technique and equipment imports. Whether the trend in rising energy intensity continues will be significant for China and the rest of the world.

  19. Long term substitution treatment (maintenance treatment of opioid dependent persons

    Directory of Open Access Journals (Sweden)

    Wirl, Charlotte

    2007-03-01

    Full Text Available Health political background: Methadone substitution treatment in Germany is introduced in 1988 in the framework of a scientific pilot study in North Rhein Westphalia. Recent statistics show that by now a broad offer of substitution treatment exists. From 1 June 2002 to 31 December 2003 113,000 substitution treatments have been recorded as being started of which around 56,000 have been recorded as ongoing treatments by 1 December 2003. Scientific background: Substitution treatment (treatment of opioid-dependent persons using substitution substances is one part of addiction treatment. Its goals are harm reduction and the stabilisation of opioid dependent persons. Integration of opioid-dependent persons in a treatment-setting, reduction of consumption of psychoactive substances, reduction of risk behaviour (primarily related to infectious diseases, decrease of mortality and improvements concerning the social, psychic and physic situation are seen as a success of substitution treatment as maintenance therapy. Research questions: The aim of this HTA report is to investigate which indicators can be used to evaluate the effectiveness of substitution treatment. Based on these indicators an evaluation of the medical, social and economical benefit of substitution treatment - also in relation to abstinence oriented treatment - is carried out. Methods: A systematic literature search was performed in 31 international databases which yielded 2451 articles with publication date between 1995 and February 2005. Results: After a twofold selection process 32 publications were included for assessment and 276 publications were used as background literature. Despite serious restrictions due to selection bias and dropout in most studies focusing on substitution treatment, reduction of consumption of illegal opioids, reduction of risk behaviour, criminal behaviour, mortality and incidence of HIV can be seen as an empirically proven success of substitution treatment

  20. 49 CFR 383.77 - Substitute for driving skills tests.

    Science.gov (United States)

    2010-10-01

    ... Substitute for driving skills tests. At the discretion of a State, the driving skill test as specified in.../she is regularly employed in a job requiring operation of a CMV, and that either: (2) He/she...

  1. Determination of Sodium in Salt Substitute by Flame Emission Spectroscopy.

    Science.gov (United States)

    Goodney, David E.

    1982-01-01

    Experimental procedures and typical student data/results are provided for an experiment determining the sodium (parts per million) in salt substitute with an error of a few percent. Problems encountered with the technique are addressed. (Author/JN)

  2. Modified broken rice starch as fat substitute in sausages

    Directory of Open Access Journals (Sweden)

    Valéria Maria Limberger

    2011-09-01

    Full Text Available The demand for low-fat beef products has led the food industry to use fat substitutes such as modified starch. About 14% of broken rice is generated during processing. Nevertheless, this by-product contains high levels of starch; being therefore, great raw material for fat substitution. This study evaluated the applicability of chemically and physically modified broken rice starch as fat substitute in sausages. Extruded and phosphorylated broken rice was used in low-fat sausage formulation. All low-fat sausages presented about 55% reduction in the fat content and around 28% reduction in the total caloric value. Fat replacement with phosphorylated and extruded broken rice starch increased the texture acceptability of low-fat sausages, when compared to low-fat sausages with no modified broken rice. Results suggest that modified broken rice can be used as fat substitute in sausage formulations, yielding lower caloric value products with acceptable sensory characteristics.

  3. Patterns of nucleotides that flank substitutions in human orthologous genes

    Directory of Open Access Journals (Sweden)

    Huang Zhuoran

    2010-07-01

    Full Text Available Abstract Background Sequence context is an important aspect of base mutagenesis, and three-base periodicity is an intrinsic property of coding sequences. However, how three-base periodicity is influenced in the vicinity of substitutions is still unclear. The effect of context on mutagenesis should be revealed in the usage of nucleotides that flank substitutions. Relative entropy (also known as Kullback-Leibler divergence is useful for finding unusual patterns in biological sequences. Results Using relative entropy, we visualized the periodic patterns in the context of substitutions in human orthologous genes. Neighbouring patterns differed both among substitution categories and within a category that occurred at three codon positions. Transition tended to occur in periodic sequences relative to transversion. Periodic signals were stronger in a set of flanking sequences of substitutions that occurred at the third-codon positions than in those that occurred at the first- or second-codon positions. To determine how the three-base periodicity was affected near the substitution sites, we fitted a sine model to the values of the relative entropy. A sine of period equal to 3 is a good approximation for the three-base periodicity at sites not in close vicinity to some substitutions. These periods were interrupted near the substitution site and then reappeared away from substitutions. A comparative analysis between the native and codon-shuffled datasets suggested that the codon usage frequency was not the sole origin of the three-base periodicity, implying that the native order of codons also played an important role in this periodicity. Synonymous codon shuffling revealed that synonymous codon usage bias was one of the factors responsible for the observed three-base periodicity. Conclusions Our results offer an efficient way to illustrate unusual periodic patterns in the context of substitutions and provide further insight into the origin of three

  4. Preparation of bioconjugates by solid-phase conjugation to ion exchange matrix-adsorbed carrier proteins

    DEFF Research Database (Denmark)

    Houen, G.; Olsen, D.T.; Hansen, P.R.;

    2003-01-01

    protein was conjugated with glutathione, the conjugation ratio determined by acid hydrolysis, and amino acid analysis performed with quantification of carboxymethyl cysteine. Elution of conjugates from the resin by a salt gradient revealed considerable heterogeneity in the degree of derivatization......, and immunization experiments with the eluted conjugates showed that the more substituted conjugates gave rise to the highest titers of glutathione antibodies. Direct immunization with the conjugates adsorbed to the ion exchange matrix was possible and gave rise to high titers of glutathione antibodies. Conjugates...

  5. Bioethics for clinicians: 5. Substitute decision-making.

    OpenAIRE

    Lazar, N M; Greiner, G G; Robertson, G; Singer, P A

    1996-01-01

    Substitute decision-making is a means of making health care decisions on behalf of people who are incapable of making these decisions for themselves. It is based on the ethical principle of respect for autonomy. Substitute decision-making poses two main questions: Who-should make the decision for the incapable person, and, How should the decision be made? Because the applicable statutory and common law varies across Canada, clinicians should become familiar with the legal requirements of thei...

  6. Perspective on the substitution of electricity for oil

    International Nuclear Information System (INIS)

    The prospects for substitution of electricity for oil are discussed. Current oil use in Canada and abroad is reviewed along with studies giving projections of future use. The author shows that electricity is in a position to adequately substitute for oil in most situations. While electricity comprised 34 percent of Canadian primary energy supply in 1979, it is expected to increase to 50 percent in 2000

  7. Dynamic Pricing and Inventory Control of Substitute Products

    OpenAIRE

    Lingxiu Dong; Panos Kouvelis; Zhongjun Tian

    2009-01-01

    We study dynamic pricing and inventory control of substitute products for a retailer who faces a long supply lead time and a short selling season. Within a multinomial logit model of consumer choice over substitutes, we develop a stochastic dynamic programming formulation and derive the optimal dynamic pricing policy. We prove that dynamic pricing converges to static pricing as inventory levels of all variates approach the number of remaining selling periods (assuming at most one customer arr...

  8. Can Cannabis be Considered a Substitute Medication for Alcohol?

    OpenAIRE

    Subbaraman, Meenakshi Sabina

    2014-01-01

    Aims: Substituting cannabis for alcohol may reduce drinking and related problems among alcohol-dependent individuals. Some even recommend prescribing medical cannabis to individuals attempting to reduce drinking. The primary aim of this review is to assess whether cannabis satisfies the seven previously published criteria for substitute medications for alcohol [e.g. ‘reduces alcohol-related harms’; ‘is safer in overdose than alcohol’; ‘should offer significant health economic benefits’; see C...

  9. Are Pornography and Marriage Substitutes for Young Men?

    OpenAIRE

    Malcolm, Michael; George S. Naufal

    2014-01-01

    Substitutes for marital sexual gratification may impact the decision to marry. Proliferation of the Internet has made pornography an increasingly low-cost substitute. We investigate the effect of Internet usage, and of pornography consumption specifically, on the marital status of young men. We show that increased Internet usage is negatively associated with marriage formation. Pornography consumption specifically has an even stronger effect. Instrumental variables and a number of robustness ...

  10. Strategic Thinking on Developing Petroleum Substitutes in China

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The continual growth of Chinese economy indicates that the oil demand in China will maintain a strongly rising tendency in the future. With increasing oil consumption, the contradiction between supply and demand will become more and more serious, which can be resolved by developing petroleum substitutes. This paper analyzes different influence factors, displays the development trend and probes into the strategy in developing petroleum substitutes in China.

  11. Consequences of Pure Point Diffraction Spectra for Multiset Substitution Systems

    OpenAIRE

    Lee, Jeong-Yup; Moody, Robert V.; Solomyak, Boris

    2009-01-01

    There is a growing body of results in the theory of discrete point sets and tiling systems giving conditions under which such systems are pure point diffractive. Here we look at the opposite direction: what can we infer about a discrete point set or tiling, defined through a primitive substitution system, given that it is pure point diffractive? Our basic objects are Delone multisets and tilings, which are self-replicating under a primitive substitution system of affine mappings with a common...

  12. 2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.

    Science.gov (United States)

    Smith, Cameron J; Ali, Amjad; Chen, Liya; Hammond, Milton L; Anderson, Matt S; Chen, Ying; Eveland, Suzanne S; Guo, Qiu; Hyland, Sheryl A; Milot, Denise P; Sparrow, Carl P; Wright, Samuel D; Sinclair, Peter J

    2010-01-01

    A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazole moiety was found to be beneficial for CETP inhibition. Compound 47 was found to be the most potent inhibitor in this series and inhibited CETP with an IC(50) of 28nM.

  13. FLU, an amino acid substitution model for influenza proteins

    OpenAIRE

    Gascuel Olivier; Le Quang; Dang Cuong; Le Vinh

    2010-01-01

    Abstract Background The amino acid substitution model is the core component of many protein analysis systems such as sequence similarity search, sequence alignment, and phylogenetic inference. Although several general amino acid substitution models have been estimated from large and diverse protein databases, they remain inappropriate for analyzing specific species, e.g., viruses. Emerging epidemics of influenza viruses raise the need for comprehensive studies of these dangerous viruses. We p...

  14. Capacitively coupled electrical substitution for resistive bolometer enhancement

    OpenAIRE

    Denoual, Matthieu; Delaunay, Sébastien; Allègre, Gilles; Robbes, Didier

    2009-01-01

    A new electrical substitution method for resistive bolometers is proposed to operate them in a closed-loop configuration. This method was implemented and evaluated with a resistive bolometer based on metallic layers over a 120 μm thick glass membrane. Based on an electrical substitution (ES) directly at the place of the resistive sensing element, the new method allows for space savings and a simplification of the technological manufacturing while maintaining the time response improvement link...

  15. Squirals and beyond: Substitution tilings with singular continuous spectrum

    CERN Document Server

    Baake, Michael

    2012-01-01

    The squiral inflation rule is equivalent to a bijective block substitution rule and leads to an interesting lattice dynamical system under the action of $\\mathbb{Z}^{2}$. In particular, its balanced version has purely singular continuous diffraction. The dynamical spectrum is of mixed type, with pure point and singular continuous components. We present a constructive proof that admits a generalisation to bijective block substitutions of trivial height on $\\mathbb{Z}^{d}$.

  16. A formal approach for correct-by-construction system substitution

    OpenAIRE

    Babin, Guillaume

    2014-01-01

    The substitution of a system with another one may occur in several situations like system adaptation, system failure management, system resilience, system reconfiguration, etc. It consists in replacing a running system by another one when given conditions hold. This contribution summarizes our proposal to define a formal setting for proving the correctness of system substitution. It relies on refinement and on the Event-B method.

  17. The role of food substitutes in a token economy system.

    Science.gov (United States)

    Scott, D W; Wood, R L

    1987-06-01

    Data from five behaviour management (token economy) units were analysed for periods of 10-20 weeks before and after the use of a food substitute (Complan), provided when insufficient tokens had been earned to buy a full- or part-meal. The efficacy of this form of negative punishment to control disturbed and aggressive behaviour was examined. No evidence was found to suggest that the contingent use of a food substitute made any contribution to the therapeutic process. PMID:3651745

  18. Biomimetic chitosan-calcium phosphate composites with potential applications as bone substitutes: preparation and characterization.

    Science.gov (United States)

    Tanase, Constantin E; Popa, Marcel I; Verestiuc, Liliana

    2012-04-01

    A novel biomimetic technique for obtaining chitosan-calcium phosphates (Cs-CP) scaffolds are presented: calcium phosphates are precipitated from its precursors, CaCl(2) and NaH(2) PO(4) on the Cs matrix, under physiological conditions (human body temperature and body fluid pH; 37°C and pH = 7.2, respectively). Materials composition and structure have been confirmed by various techniques: elemental analysis, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), and scanning electron microscopy (SEM). FTIR and SEM data have shown the arrangement of the calcium phosphates-hydroxyapatite (CP-Hap) onto Cs matrix. In this case the polymer is acting as glue, bonding the calcium phosphates crystals. Behavior in biological simulated fluids (phosphate buffer solution-PBS and PBS-albumin) revealed an important contribution of the chelation between -NH3(+) and Ca(2+) on the scaffold interaction with aqueous mediums; increased quantities of chitosan in composites permit the interaction with human albumin and improve the retention of fluid. The composites are slightly degraded by the lysozyme which facilitates an in vivo degradation control of bone substitutes. Modulus of elasticity is strongly dependent of the ratio chitosan/calcium phosphates and recommends the obtained biomimetic composites as promising materials for a prospective bone application. PMID:22121073

  19. Optimized Projection Matrix for Compressive Sensing

    Directory of Open Access Journals (Sweden)

    Jianping Xu

    2010-01-01

    Full Text Available Compressive sensing (CS is mainly concerned with low-coherence pairs, since the number of samples needed to recover the signal is proportional to the mutual coherence between projection matrix and sparsifying matrix. Until now, papers on CS always assume the projection matrix to be a random matrix. In this paper, aiming at minimizing the mutual coherence, a method is proposed to optimize the projection matrix. This method is based on equiangular tight frame (ETF design because an ETF has minimum coherence. It is impossible to solve the problem exactly because of the complexity. Therefore, an alternating minimization type method is used to find a feasible solution. The optimally designed projection matrix can further reduce the necessary number of samples for recovery or improve the recovery accuracy. The proposed method demonstrates better performance than conventional optimization methods, which brings benefits to both basis pursuit and orthogonal matching pursuit.

  20. The Extracellular Matrix of Fungal Biofilms.

    Science.gov (United States)

    Mitchell, Kaitlin F; Zarnowski, Robert; Andes, David R

    2016-01-01

    A key feature of biofilms is their production of an extracellular matrix. This material covers the biofilm cells, providing a protective barrier to the surrounding environment. During an infection setting, this can include such offenses as host cells and products of the immune system as well as drugs used for treatment. Studies over the past two decades have revealed the matrix from different biofilm species to be as diverse as the microbes themselves. This chapter will review the composition and roles of matrix from fungal biofilms, with primary focus on Candida species, Saccharomyces cerevisiae, Aspergillus fumigatus, and Cryptococcus neoformans. Additional coverage will be provided on the antifungal resistance proffered by the Candida albicans matrix, which has been studied in the most depth. A brief section on the matrix produced by bacterial biofilms will be provided for comparison. Current tools for studying the matrix will also be discussed, as well as suggestions for areas of future study in this field. PMID:27271680

  1. Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis

    Directory of Open Access Journals (Sweden)

    Grabellus Florian

    2011-08-01

    Full Text Available Abstract Background Periprosthetic osteolysis is a major cause of aseptic loosening in joint arthroplasty. This study investigates the impact of CT (calcitonin deficiency and CT substitution under in-vivo circumstances on particle-induced osteolysis in Calca -/- mice. Methods We used the murine calvarial osteolysis model based on ultra-high molecular weight polyethylene (UHMWPE particles in 10 C57BL/6J wild-type (WT mice and twenty Calca -/- mice. The mice were divided into six groups: WT without UHMWPE particles (Group 1, WT with UHMWPE particles (Group 2, Calca -/- mice without UHMWPE particles (Group 3, Calca -/- mice with UHMWPE particles (Group 4, Calca -/- mice without UHMWPE particles and calcitonin substitution (Group 5, and Calca -/- mice with UHMWPE particle implantation and calcitonin substitution (Group 6. Analytes were extracted from serum and urine. Bone resorption was measured by bone histomorphometry. The number of osteoclasts was determined by counting the tartrate-resistant acid phosphatase (TRACP + cells. Results Bone resorption was significantly increased in Calca -/- mice compared with their corresponding WT. The eroded surface in Calca -/- mice with particle implantation was reduced by 20.6% after CT substitution. Osteoclast numbers were significantly increased in Calca -/- mice after particle implantation. Serum OPG (osteoprotegerin increased significantly after CT substitution. Conclusions As anticipated, Calca -/- mice show extensive osteolysis compared with wild-type mice, and CT substitution reduces particle-induced osteolysis.

  2. A study of photon interaction parameters in lung tissue substitutes

    Directory of Open Access Journals (Sweden)

    H C Manjunatha

    2014-01-01

    Full Text Available The study of photon interaction with different composite materials has become a topic of prime importance for radiation physicists. Some parameters of dosimetric interest are the mass attenuation coefficient, effective atomic number, and electron density; these help in the basic understanding of photon interactions with composite materials. The photon interaction parameters such as mass attenuation coefficient (μ/ρ, effective atomic number (Z eff , and effective electron density (N el must be identical for the phantom material and their tissue. In the present study, we have evaluated the photon interaction parameters such as (μ/ρ, Z eff and N el of 13 lung tissue substitutes. The variations of these parameters of lung tissue substitutes with photon energy are graphically represented. The photon interaction parameters of lung tissue substitutes are compared with that of lung tissue. The variation of photon interaction parameters of the studied lung tissue substitutes is similar that of the lung. Logically, it can be shown that Alderson lung is good substitute for lung than the other substitutes.

  3. A study of photon interaction parameters in lung tissue substitutes.

    Science.gov (United States)

    Manjunatha, H C

    2014-04-01

    The study of photon interaction with different composite materials has become a topic of prime importance for radiation physicists. Some parameters of dosimetric interest are the mass attenuation coefficient, effective atomic number, and electron density; these help in the basic understanding of photon interactions with composite materials. The photon interaction parameters such as mass attenuation coefficient (μ/ρ), effective atomic number (Zeff), and effective electron density (N el) must be identical for the phantom material and their tissue. In the present study, we have evaluated the photon interaction parameters such as (μ/ρ), Z eff and N el of 13 lung tissue substitutes. The variations of these parameters of lung tissue substitutes with photon energy are graphically represented. The photon interaction parameters of lung tissue substitutes are compared with that of lung tissue. The variation of photon interaction parameters of the studied lung tissue substitutes is similar that of the lung. Logically, it can be shown that Alderson lung is good substitute for lung than the other substitutes. PMID:24872609

  4. Electrophoretic deposition of zinc-substituted hydroxyapatite coatings

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Guangfei [Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074 (China); Ma, Jun, E-mail: caltary@gmail.com [Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074 (China); Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Zhang, Shengmin [Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074 (China); Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2014-06-01

    Zinc-substituted hydroxyapatite nanoparticles synthesized by the co-precipitation method were used to coat stainless steel plates by electrophoretic deposition in n-butanol with triethanolamine as a dispersant. The effect of zinc concentration in the synthesis on the morphology and microstructure of coatings was investigated. It is found that the deposition current densities significantly increase with the increasing zinc concentration. The zinc-substituted hydroxyapatite coatings were analyzed by X-ray diffraction, scanning electron microscopy and Fourier transform infrared spectroscopy. It is inferred that hydroxyapatite and triethanolamine predominate in the chemical composition of coatings. With the increasing Zn/Ca ratios, the contents of triethanolamine decrease in the final products. The triethanolamine can be burnt out by heat treatment. The tests of adhesive strength have confirmed good adhesion between the coatings and substrates. The formation of new apatite layer on the coatings has been observed after 7 days of immersion in a simulated body fluid. In summary, the results show that dense, uniform zinc-substituted hydroxyapatite coatings are obtained by electrophoretic deposition when the Zn/Ca ratio reaches 5%. - Highlights: • We investigate the Zn/Ca ratios for the synthesis of zinc-substituted HA. • Zinc-substituted HA nanoparticles are used for electrophoretic deposition. • Adding triethanolamine and HCl may aid electrophoretic deposition. • Uniform dense coatings of zinc-substituted HA are obtained when Zn/Ca = 5%.

  5. Neutron kerma factors, and water equivalence of some tissue substitutes

    Energy Technology Data Exchange (ETDEWEB)

    Singh, V. P.; Badiger, N. M. [Karnatak University, Department of Physics, Dharwad, 580003 (India); Vega C, H. R., E-mail: kudphyvps@rediffmail.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2014-08-15

    The kerma factors and kerma relative to air and water of 24 compounds used as tissue substitutes were calculated for neutron energy from 2.53 x 10{sup -8} up to 29 MeV. The kerma ratio of the tissue substitutes relative to air and water were calculated by the ratio of kerma factors of the tissue substitute to air and water respectively. The water equivalence of the selected tissue substitutes was observed above neutron energies 100 eV. Kerma ratio relative to the air for Poly-vinylidene fluoride and Teflon are found to be nearest to unity in very low energy (up to 1 eV) and above 63 eV respectively. It was found that the natural rubber as a water equivalent tissue substitute compound. The results of the kerma factors in our investigation shows a very good agreement with those published in ICRU-44. We found that at higher neutron energies, the kerma factors and kerma ratios of the selected tissue substitute compounds are approximately same, but differences are large for energies below 100 eV. (Author)

  6. Generation of a Fibrin Based Three-Layered Skin Substitute

    Directory of Open Access Journals (Sweden)

    Johanna Kober

    2015-01-01

    Full Text Available A variety of skin substitutes that restore epidermal and dermal structures are currently available on the market. However, the main focus in research and clinical application lies on dermal and epidermal substitutes whereas the development of a subcutaneous replacement (hypodermis is often disregarded. In this study we used fibrin sealant as hydrogel scaffold to generate a three-layered skin substitute. For the hypodermal layer adipose-derived stem cells (ASCs and mature adipocytes were embedded in the fibrin hydrogel and were combined with another fibrin clot with fibroblasts for the construction of the dermal layer. Keratinocytes were added on top of the two-layered construct to form the epidermal layer. The three-layered construct was cultivated for up to 3 weeks. Our results show that ASCs and fibroblasts were viable, proliferated normally, and showed physiological morphology in the skin substitute. ASCs were able to differentiate into mature adipocytes during the course of four weeks and showed morphological resemblance to native adipose tissue. On the surface keratinocytes formed an epithelial-like layer. For the first time we were able to generate a three-layered skin substitute based on a fibrin hydrogel not only serving as a dermal and epidermal substitute but also including the hypodermis.

  7. MDL, Collineations and the Fundamental Matrix

    OpenAIRE

    Maybank, Steve; Sturm, Peter

    1999-01-01

    International audience Scene geometry can be inferred from point correspondences between two images. The inference process includes the selection of a model. Four models are considered: background (or null), collineation, affine fundamental matrix and fundamental matrix. It is shown how Minimum Description Length (MDL) can be used to compare the different models. The main result is that there is little reason for preferring the fundamental matrix model over the collineation model, even whe...

  8. Imposing causality on a matrix model

    International Nuclear Information System (INIS)

    We introduce a new matrix model that describes Causal Dynamical Triangulations (CDT) in two dimensions. In order to do so, we introduce a new, simpler definition of 2D CDT and show it to be equivalent to the old one. The model makes use of ideas from dually weighted matrix models, combined with multi-matrix models, and can be studied by the method of character expansion.

  9. A New Proposal for Matrix Theory

    OpenAIRE

    Chaudhuri, Shyamoli

    2002-01-01

    We explain the motivation and main ideas underlying our proposal for a Lagrangian for Matrix Theory based on sixteen supercharges. Starting with the pedagogical example of a bosonic matrix theory we describe the appearance of a continuum spacetime geometry from a discrete, and noncommutative, spacetime with both Lorentz and Yang-Mills invariances. We explain the appearance of large N ground states with Dbranes and elucidate the principle of matrix Dbrane democracy at finite N. Based on the un...

  10. A note on quantization of matrix models

    OpenAIRE

    Starodubtsev, Artem

    2002-01-01

    The issue of non-perturbative background independent quantization of matrix models is addressed. The analysis is carried out by considering a simple matrix model which is a matrix extension of ordinary mechanics reduced to 0 dimension. It is shown that this model has an ordinary mechanical system evolving in time as a classical solution. But in this treatment the action principle admits a natural modification which results in algebraic relations describing quantum theory. The origin of quanti...

  11. Riemann--Hilbert problems, matrix orthogonal polynomials and discrete matrix equations with singularity confinement

    CERN Document Server

    Cassatella-Contra, Giovanni A

    2011-01-01

    In this paper matrix orthogonal polynomials in the real line are described in terms of a Riemann--Hilbert problem. This approach provides an easy derivation of discrete equations for the corresponding matrix recursion coefficients. The discrete equation is explicitly derived in the matrix Freud case, associated with matrix quartic potentials. It is shown that, when the initial condition and the measure are simultaneously triangularizable, this matrix discrete equation possesses the singularity confinement property, independently if the solution under consideration is given by recursion coefficients to quartic Freud matrix orthogonal polynomials or not.

  12. Noval 1-substituted-3,5-dimethyl-4-[(substituted phenyl diazenyl] pyrazole derivatives: Synthesis and pharmacological activity

    Directory of Open Access Journals (Sweden)

    Sabir Hussain

    2015-05-01

    Full Text Available Several-1-carbothioamide-3,5-dimethyl-4-[(substituted phenyl diazenyl] pyrazoles 2a–d, 1-(pyridine-4-ylcarbonyl-3,5-dimethyl-4-[(substituted phenyl diazenyl] pyrazoles 3a–d, 1-(5-chloro-6-fluoro-1,3-benzothiazole-2-ylthiocarbamoyl-3,5-dimethyl-4-[(substituted phenyl diazenyl] pyrazoles 4a–d and 1-[(1,2,4-triazole-4-yl carbothioamide]-3,5-dimethyl-4-[(substituted phenyl diazenyl] pyrazoles 5a–d were synthesized. The structures of the newly synthesized compounds were supported by IR, 1H NMR and mass spectral data. These compounds were investigated for their, anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, antibacterial and antifungal activities. Some of the synthesized compounds showed potent anti-inflammatory activity along with minimal ulcerogenic effect and lipid peroxidation, compared to ibuprofen and flurbiprofen. Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains.

  13. Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface

    Science.gov (United States)

    Huang, Baolin; Yuan, Yuan; Li, Tong; Ding, Sai; Zhang, Wenjing; Gu, Yuantong; Liu, Changsheng

    2016-04-01

    Biomaterial surface functionalized with bone morphogenetic protein-2 (BMP-2) is a promising approach to fabricating successful orthopedic implants/scaffolds. However, the bioactivity of BMP-2 on material surfaces is still far from satisfactory and the mechanism of related protein-surface interaction remains elusive. Based on the most widely used bone-implants/scaffolds material, hydroxyapatite (HAP), we developed a matrix of magnesium-substituted HAP (Mg-HAP, 2.2 at% substitution) to address these issues. Further, we investigated the adsorption dynamics, BMPRs-recruitment, and bioactivity of recombinant human BMP-2 (rhBMP-2) on the HAP and Mg-HAP surfaces. To elucidate the mechanism, molecular dynamic simulations were performed to calculate the preferred orientations, conformation changes, and cysteine-knot stabilities of adsorbed BMP-2 molecules. The results showed that rhBMP-2 on the Mg-HAP surface exhibited greater bioactivity, evidenced by more facilitated BMPRs-recognition and higher ALP activity than on the HAP surface. Moreover, molecular simulations indicated that BMP-2 favoured distinct side-on orientations on the HAP and Mg-HAP surfaces. Intriguingly, BMP-2 on the Mg-HAP surface largely preserved the active protein structure evidenced by more stable cysteine-knots than on the HAP surface. These findings explicitly clarify the mechanism of BMP-2-HAP/Mg-HAP interactions and highlight the promising application of Mg-HAP/BMP-2 matrixes in bone regeneration implants/scaffolds.

  14. Reactive Power Compensation using a Matrix Converter

    OpenAIRE

    Holtsmark, Nathalie Marie-Anna

    2010-01-01

    This Master's thesis investigates a new application for the matrix converter: Shunt reactive power compensation. The suggested Matrix Converter-based Reactive power Compensation (MCRC) device is composed of a matrix converter, which input is connected to the grid and an electric machine at the output of the converter. The reactive power flowing in or out of the grid can be regulated with the matrix converter by controlling the magnitude and/or phase angle of the current at the input of the co...

  15. Basic matrix algebra and transistor circuits

    CERN Document Server

    Zelinger, G

    1963-01-01

    Basic Matrix Algebra and Transistor Circuits deals with mastering the techniques of matrix algebra for application in transistors. This book attempts to unify fundamental subjects, such as matrix algebra, four-terminal network theory, transistor equivalent circuits, and pertinent design matters. Part I of this book focuses on basic matrix algebra of four-terminal networks, with descriptions of the different systems of matrices. This part also discusses both simple and complex network configurations and their associated transmission. This discussion is followed by the alternative methods of de

  16. Matrix Krylov subspace methods for image restoration

    Directory of Open Access Journals (Sweden)

    khalide jbilou

    2015-09-01

    Full Text Available In the present paper, we consider some matrix Krylov subspace methods for solving ill-posed linear matrix equations and in those problems coming from the restoration of blurred and noisy images. Applying the well known Tikhonov regularization procedure leads to a Sylvester matrix equation depending the Tikhonov regularized parameter. We apply the matrix versions of the well known Krylov subspace methods, namely the Least Squared (LSQR and the conjugate gradient (CG methods to get approximate solutions representing the restored images. Some numerical tests are presented to show the effectiveness of the proposed methods.

  17. Symmetries and interactions in matrix string theory

    OpenAIRE

    Hacquebord, F.H.

    1999-01-01

    This PhD-thesis reviews matrix string theory and recent developments therein. The emphasis is put on symmetries, interactions and scattering processes in the matrix model. We start with an introduction to matrix string theory and a review of the orbifold model that flows out of matrix string theory in the strong YM coupling limit. Then we turn our attention to the appearance of U-duality symmetry in gauge models, after a (very) short summary of string duality, D-branes and M-theory. The last ...

  18. New recursive algorithm for matrix inversion

    Institute of Scientific and Technical Information of China (English)

    Cao Jianshu; Wang Xuegang

    2008-01-01

    To reduce the computational complexity of matrix inversion, which is the majority of processing in many practical applications, two numerically efficient recursive algorithms (called algorithms Ⅰ and Ⅱ, respectively)are presented. Algorithm Ⅰ is used to calculate the inverse of such a matrix, whose leading principal minors are all nonzero. Algorithm Ⅱ, whereby, the inverse of an arbitrary nonsingular matrix can be evaluated is derived via improving the algorithm Ⅰ. The implementation, for algorithm Ⅱ or Ⅰ, involves matrix-vector multiplications and vector outer products. These operations are computationally fast and highly parallelizable. MATLAB simulations show that both recursive algorithms are valid.

  19. Risk matrix model for rotating equipment

    Directory of Open Access Journals (Sweden)

    Wassan Rano Khan

    2014-07-01

    Full Text Available Different industries have various residual risk levels for their rotating equipment. Accordingly the occurrence rate of the failures and associated failure consequences categories are different. Thus, a generalized risk matrix model is developed in this study which can fit various available risk matrix standards. This generalized risk matrix will be helpful to develop new risk matrix, to fit the required risk assessment scenario for rotating equipment. Power generation system was taken as case study. It was observed that eight subsystems were under risk. Only vibration monitor system was under high risk category, while remaining seven subsystems were under serious and medium risk categories.

  20. A random matrix theory of decoherence

    Science.gov (United States)

    Gorin, T.; Pineda, C.; Kohler, H.; Seligman, T. H.

    2008-11-01

    Random matrix theory is used to represent generic loss of coherence of a fixed central system coupled to a quantum-chaotic environment, represented by a random matrix ensemble, via random interactions. We study the average density matrix arising from the ensemble induced, in contrast to previous studies where the average values of purity, concurrence and entropy were considered; we further discuss when one or the other approach is relevant. The two approaches agree in the limit of large environments. Analytic results for the average density matrix and its purity are presented in linear response approximation. The two-qubit system is analysed, mainly numerically, in more detail.