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Sample records for blaster kolib pci-e-le

  1. Maakera supitehas kolib Põlvast minema / Väinu Rozental

    Index Scriptorium Estoniae

    Rozental, Väinu, 1957-

    2007-01-01

    Põlvas asuva Maakera kaubamärgi all tegutseva valmistoidutehase AS-i Nordic Foods ostnud AS Põltsamaa Felix kolib tootmise Põlvast emafirmasse Põltsamaale. Lisa: Põlva supitehas elas kaks ja pool aastat

  2. GapBlaster-A Graphical Gap Filler for Prokaryote Genomes.

    Directory of Open Access Journals (Sweden)

    Pablo H C G de Sá

    Full Text Available The advent of NGS (Next Generation Sequencing technologies has resulted in an exponential increase in the number of complete genomes available in biological databases. This advance has allowed the development of several computational tools enabling analyses of large amounts of data in each of the various steps, from processing and quality filtering to gap filling and manual curation. The tools developed for gap closure are very useful as they result in more complete genomes, which will influence downstream analyses of genomic plasticity and comparative genomics. However, the gap filling step remains a challenge for genome assembly, often requiring manual intervention. Here, we present GapBlaster, a graphical application to evaluate and close gaps. GapBlaster was developed via Java programming language. The software uses contigs obtained in the assembly of the genome to perform an alignment against a draft of the genome/scaffold, using BLAST or Mummer to close gaps. Then, all identified alignments of contigs that extend through the gaps in the draft sequence are presented to the user for further evaluation via the GapBlaster graphical interface. GapBlaster presents significant results compared to other similar software and has the advantage of offering a graphical interface for manual curation of the gaps. GapBlaster program, the user guide and the test datasets are freely available at https://sourceforge.net/projects/gapblaster2015/. It requires Sun JDK 8 and Blast or Mummer.

  3. Concrete Cleaning, Inc. centrifugal shot blaster: Baseline report; Summary

    International Nuclear Information System (INIS)

    1997-01-01

    The centrifugal shot blaster is an electronically operated shot-blast machine that removes layer of concrete of varying depths. Hardened steel shot propelled at a high rate of speed abrades the surface of the concrete. The depth of material removed is determined by the rate of speed the machine is traveling and the volume of shot being fired into the blast chamber. The steel shot is reused until it is pulverized to dust, which is deposited in the waste container with the concrete being removed. Debris is continually vacuumed by a large dust collection system attached to the shot blaster. The safety and health evaluation during the human factors assessment focused on two main areas: noise and dust

  4. SandBlaster: Reversing the Apple Sandbox

    OpenAIRE

    Deaconescu, Răzvan; Deshotels, Luke; Bucicoiu, Mihai; Enck, William; Davi, Lucas; Sadeghi, Ahmad-Reza

    2016-01-01

    In order to limit the damage of malware on Mac OS X and iOS, Apple uses sandboxing, a kernel-level security layer that provides tight constraints for system calls. Particularly used for Apple iOS, sandboxing prevents apps from executing potentially dangerous actions, by defining rules in a sandbox profile. Investigating Apple's built-in sandbox profiles is difficult as they are compiled and stored in binary format. We present SandBlaster, a software bundle that is able to reverse/decompile Ap...

  5. PCI compliance understand and implement effective PCI data security standard compliance

    CERN Document Server

    Williams, Branden R

    2012-01-01

    The credit card industry established the PCI Data Security Standards to provide a minimum standard for how vendors should protect data to ensure it is not stolen by fraudsters. PCI Compliance, 3e, provides the information readers need to understand the current PCI Data Security standards, which have recently been updated to version 2.0, and how to effectively implement security within your company to be compliant with the credit card industry guidelines and protect sensitive and personally identifiable information. Security breaches continue to occur on a regular basis, affecting millions of

  6. PCI-kortin muuntaminen PCI Express -kortiksi

    OpenAIRE

    Vilander, Joel

    2016-01-01

    Opinnäytetyön tarkoituksena oli suunnitella ja toteuttaa yritykselle PCI-väylään kytkettävän kortin tilalle jokin modernimpi vaihtoehto kuitenkin tekemällä uuden laitteen toiminnasta yhteensopiva kohdelaitteen kanssa. Kortin muuntaminen PCI Express -väylän kanssa yhteensopivaksi oli lopulta kaikkein miellyttävin ratkaisu. Opinnäytetyössä perehdytään PCI- ja PCI Express -väylien toimintaan sekä elektroniikka– ja piirilevysuunnitteluun liittyviin asioihin. The purpose of this thesis is ...

  7. Caracterização e Beneficiamento Primário de Placas de Circuito Impresso (PCI de Telefones Celulares

    Directory of Open Access Journals (Sweden)

    Theo Antonio de Jesus

    2015-12-01

    Full Text Available Devido ao constante avanço tecnológico, uma grande quantidade de aparelhos é descartada por obsolescência tecnológica ou defeitos. Isto acarreta a contaminação do solo e do lençol freático, além de representar perda econômica pois as PCI (placas de circuito impresso dos telefones celulares são ricas em metais pesados e alguns metais valiosos. Com o objetivo de conhecer melhor a composição e concentração destas PCI de modo a otimizar os processos de reciclagem, foi realizada a caracterização das PCI através da digestão em água régia e da utilização das técnicas de DRx (difração de raios x e FRx (espectrometria de fluorescência de raios x. Os resultados proporcionaram conhecimento suficiente a respeito da composição e concentração dos principais metais das PCI. A presença de ouro, prata e cobre chama a atenção para o potencial econômico destes resíduos. Estudos são necessários para desenvolver os processos mais adequados com vistas a concentrar estes metais e viabilizar sua reciclagem.

  8. CABG Versus PCI

    Science.gov (United States)

    Habib, Robert H.; Dimitrova, Kamellia R.; Badour, Sanaa A.; Yammine, Maroun B.; El-Hage-Sleiman, Abdul-Karim M.; Hoffman, Darryl M.; Geller, Charles M.; Schwann, Thomas A.; Tranbaugh, Robert F.

    2017-01-01

    BACKGROUND Treatment of multivessel coronary artery disease with traditional single-arterial coronary artery bypass graft (SA-CABG) has been associated with superior intermediate-term survival and reintervention compared with percutaneous coronary intervention (PCI) using either bare-metal stents (BMS) or drug-eluting stents (DES). OBJECTIVES This study sought to investigate longer-term outcomes including the potential added advantage of multiarterial coronary artery bypass graft (MA-CABG). METHODS We studied 8,402 single-institution, primary revascularization, multivessel coronary artery disease patients: 2,207 BMS-PCI (age 66.6 ± 11.9 years); 2,381 DES-PCI (age 65.9 ± 11.7 years); 2,289 SA-CABG (age 69.3 ± 9.0 years); and 1,525 MA-CABG (age 58.3 ± 8.7 years). Patients with myocardial infarction within 24 h, shock, or left main stents were excluded. Kaplan-Meier analysis and Cox regression were used to separately compare 9-year all-cause mortality and unplanned reintervention for BMS-PCI and DES-PCI to respective propensity-matched SA-CABG and MA-CABG cohorts. RESULTS BMS-PCI was associated with worse survival than SA-CABG, especially from 0 to 7 years (p = 0.015) and to a greater extent than MA-CABG was (9-year follow-up: 76.3% vs. 86.9%; p PCI hazard ratios (HR) were as follows: versus SA-CABG, HR: 0.87; and versus MA-CABG, HR: 0.38. DES-PCI showed similar survival to SA-CABG except for a modest 0 to 3 years surgery advantage (HR: 1.06; p = 0.615). Compared with MA-CABG, DES-PCI exhibited worse survival at 5 (86.3% vs. 95.6%) and 9 (82.8% vs. 89.8%) years (HR: 0.45; p PCI for all comparisons (all p PCI or DES-PCI, resulted in substantially enhanced death and reintervention-free survival. Accordingly, MA-CABG represents the optimal therapy for multivessel coronary artery disease and should be enthusiastically adopted by multidisciplinary heart teams as the best evidence-based therapy. PMID:26403338

  9. Bowlers, ballads, bells, and blasters: Living history and fandom [symposium

    Directory of Open Access Journals (Sweden)

    Mark Soderstrom

    2011-03-01

    Full Text Available In many people's lives the disposition to create community around historical interest or reenacted historical community practices, or even just entertainment in a mythic-history setting, intersects with a related and similar interest in science fiction/fantasy literature and participation on some level in the related fandoms and social activities of SF/F. The bowlers, ballads, bells, and blasters of my title come together not just in current steampunk scenes but also in the storied and genred lives of many reenactors and fans. Or, as a friend of mine suggested when discussing this essay, "historical reenactment is the trade secret to fandom."

  10. Un’architettura per e con le persone

    Directory of Open Access Journals (Sweden)

    Alessandro Rigolon

    2011-06-01

    Full Text Available L’articolo propone un approccio umanistico al progetto architettonico, ponendo le persone al centro del processo di concezione. Comprendere il modo in cui lo spazio influenza il comportamento, le emozioni e le attività delle persone dovrebbe essere il punto di partenza del progetto. Ciò implica una riflessione sui mezzi con i quali lo spazio trasmette significati connotativi e denotativi. Le tecniche per raccogliere informazioni dagli utenti e per includere tali informazioni nel progetto sono state analizzate per evidenziare i vantaggi e i problemi del mettere in pratica tale approccio umanistico. La discussione finale è focalizzata sulla possibile perdita di autonomia del progettista, sulla tempistica dell’introduzione dei dati derivati dagli utenti e sulle conseguenze dell’inclusione di tali dati nelle normali pratiche progettuali.

  11. PCI. Mechanism, measures, rules for reactor operation

    International Nuclear Information System (INIS)

    Bender, D.; Bender, G.; Dewes, P.; Wensauer, A.

    2009-01-01

    Though modern and advanced fuel assembly designs for BWR as AREVA's ATRIUM trademark 10 fuel assemblies show a high reliability, fuel failures are still encountered. The ZTF (Zero Tolerance for Failures) initiative was launched by AREVA to further upgrade BWR fuel assembly reliability towards failure free fuel. The introduction of the zirconium liner cladding has greatly reduced pellet cladding interaction (PCI) failures. However the phenomenon of PCI in reactor operation was not completely eliminated. There were failures in AREVA's BWR fuel with liner cladding attributed to PCI, but when subject to hot cell examinations, all these have been attributed to ''non-classical'' PCI, where local cladding stress is amplified due to missing pellet surface (MPS). However, in order to support the efforts to eliminate all possible root causes for fuel failures, AREVA NP addresses PCI with a ''multi-track'' strategy. First, and most important, the development of chromia doped pellets and more favorable pellet geometries aim at fuel that by design is protected as much as possible against PCI. A high pellet quality is further assured by the final assessment of the pellet appearance by an automatic visual inspection system in the pellet manufacturing lines. In order to support these hardware improvements, AREVA NP provides software aimed to minimize PCI risks. Two main approaches are described in this paper: - The ''classical'' PCI operation and maneuvering guidelines restrict power maneuvering and limit the ramping rates with the goal to control the stress level of the cladding. AREVA's guidelines are based on ramp tests as well as on extensive power plant experience, and are updated to reflect the performance of liner cladding. - Additional effort is made to further understand the PCI phenomenon, e.g. by the use of detailed fuel rod thermal-mechanical codes that provide far better insight of the state variables that control the process of rupture due to stress corrosion

  12. A+-Helix of Protein C Inhibitor (PCI) Is a Cell-penetrating Peptide That Mediates Cell Membrane Permeation of PCI*

    Science.gov (United States)

    Yang, Hanjiang; Wahlmüller, Felix Christof; Sarg, Bettina; Furtmüller, Margareta; Geiger, Margarethe

    2015-01-01

    Protein C inhibitor (PCI) is a serpin with broad protease reactivity. It binds glycosaminoglycans and certain phospholipids that can modulate its inhibitory activity. PCI can penetrate through cellular membranes via binding to phosphatidylethanolamine. The exact mechanism of PCI internalization and the intracellular role of the serpin are not well understood. Here we showed that testisin, a glycosylphosphatidylinositol-anchored serine protease, cleaved human PCI and mouse PCI (mPCI) at their reactive sites as well as at sites close to their N terminus. This cleavage was observed not only with testisin in solution but also with cell membrane-anchored testisin on U937 cells. The cleavage close to the N terminus released peptides rich in basic amino acids. Synthetic peptides corresponding to the released peptides of human PCI (His1–Arg11) and mPCI (Arg1–Ala18) functioned as cell-penetrating peptides. Because intact mPCI but not testisin-cleaved mPCI was internalized by Jurkat T cells, a truncated mPCI mimicking testisin-cleaved mPCI was created. The truncated mPCI lacking 18 amino acids at the N terminus was not taken up by Jurkat T cells. Therefore our model suggests that testisin or other proteases could regulate the internalization of PCI by removing its N terminus. This may represent one of the mechanisms regulating the intracellular functions of PCI. PMID:25488662

  13. Mechanisms for the reactions of group 10 transition metal complexes with metal-group 14 element bonds, Bbt(Br)E═M(PCy3)2 (E = C, Si, Ge, Sn, Pb; M = Pd and Pt).

    Science.gov (United States)

    Liao, Wei-Hung; Ho, Pei-Yun; Su, Ming-Der

    2013-02-04

    The electronic structures of the Bbt(Br)E═M(PCy(3))(2) (E = C, Si, Ge, Sn, Pb and M = Pt, Pd) complexes and their potential energy surfaces for the formation and water addition reactions were studied using density functional theory (B3LYP/LANL2DZ). The theoretical evidence suggests that the bonding character of the E═M double bond between the six valence-electron Bbt(Br)E: species and the 14 valence-electron (PCy(3))(2)M complexes has a predominantly high s-character. That is, on the basis of the NBO, this theoretical study indicates that the σ-donation from the E element to the M atom prevails. Also, theoretical computations suggest that the relative reactivity decreases in the order: Bbt(Br)C═M(PCy(3))(2) > Bbt(Br)Si═M(PCy(3))(2) > Bbt(Br)Ge═M(PCy(3))(2) > Bbt(Br)Sn═M(PCy(3))(2) > Bbt(Br)Pb═M(PCy(3))(2), irrespective of whether M = Pt or M = Pd is chosen. Namely, the greater the atomic weight of the group 14 atom (E), the larger is the atomic radius of E and the more stable is its Bbt(Br)E═M(PCy(3))(2) doubly bonded species toward chemical reactions. The computational results show good agreement with the available experimental observations. The theoretical results obtained in this work allow a number of predictions to be made.

  14. Future of the PCI Readmission Metric.

    Science.gov (United States)

    Wasfy, Jason H; Yeh, Robert W

    2016-03-01

    Between 2013 and 2014, the Centers for Medicare and Medicaid Services and the National Cardiovascular Data Registry publically reported risk-adjusted 30-day readmission rates after percutaneous coronary intervention (PCI) as a pilot project. A key strength of this public reporting effort included risk adjustment with clinical rather than administrative data. Furthermore, because readmission after PCI is common, expensive, and preventable, this metric has substantial potential to improve quality and value in American cardiology care. Despite this, concerns about the metric exist. For example, few PCI readmissions are caused by procedural complications, limiting the extent to which improved procedural technique can reduce readmissions. Also, similar to other readmission measures, PCI readmission is associated with socioeconomic status and race. Accordingly, the metric may unfairly penalize hospitals that care for underserved patients. Perhaps in the context of these limitations, Centers for Medicare and Medicaid Services has not yet included PCI readmission among metrics that determine Medicare financial penalties. Nevertheless, provider organizations may still wish to focus on this metric to improve value for cardiology patients. PCI readmission is associated with low-risk chest discomfort and patient anxiety. Therefore, patient education, improved triage mechanisms, and improved care coordination offer opportunities to minimize PCI readmissions. Because PCI readmission is common and costly, reducing PCI readmission offers provider organizations a compelling target to improve the quality of care, and also performance in contracts involve shared financial risk. © 2016 American Heart Association, Inc.

  15. Influence of operator experience and PCI volume on transfemoral access techniques: A collaboration of international cardiovascular societies.

    Science.gov (United States)

    Nelson, Daniel W; Damluji, Abdulla A; Patel, Nish; Valgimigli, Marco; Windecker, Stephan; Byrne, Robert; Nolan, James; Patel, Tejas; Brilakis, Emmanouil; Banerjee, Subhash; Mayol, Jorge; Cantor, Warren J; Alfonso, Carlos E; Rao, Sunil V; Moscucci, Mauro; Cohen, Mauricio G

    2018-03-01

    Transfemoral access (TFA) is widely used for coronary angiography and percutaneous coronary intervention (PCI). The influence of operator age, gender, experience, and procedural volume on performance of femoral arterial access has not been studied. A survey instrument was developed and distributed via e-mail from professional societies to interventional cardiologists worldwide from March to December 2016. A total of 988 physicians from 88 countries responded to the survey. TFA is the preferred approach for patients with cardiogenic shock, left main or bifurcation PCI, and procedures with mechanical circulatory support. Older (PCI volume operators (PCI: 57.3%; 100-299 PCI: 58.7%; ≥300 PCI: 64.3%, pPCI volume operators (≥300 PCI: 64.1%; 100-299 PCI: 72.6%; PCI: 67.9%, pPCI volume interventional cardiologists prefer not to use imaging for femoral access or perform femoral angiography during TF procedures. These data highlight opportunities to further reduce TFA complications. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Behandling av akutt hjerteinfarkt : Trombolyse versus PCI

    OpenAIRE

    Grut, Harald

    2007-01-01

    ABSTRACT Title: Treatment of acute myocardial infarction: Trombolysis versus PCI Background: Acute myocardial infarction is a frequent cause of mortality and morbidity in Norway and other Western countries. The main objective was to examine which treatment would give the best result in the case of an acute myocardial infarction, trombolysis or PCI, considering both mortality and morbidity. I also wanted to compare PCI to facilitated PCI and prehospital trombolysis. Methods: This ...

  17. Pronto chi parla. Cesare e le intercettazioni telefoniche

    Directory of Open Access Journals (Sweden)

    Paolo Caponi

    2010-03-01

    Full Text Available Pronto chi parla. Cesare e le intercettazioni telefoniche (Ugo Guspini, L’orecchio del regime. Le intercettazioni telefoniche al tempo del fascismo, Milano, Mursia, 1973, pp. 262 di Paolo Caponi

  18. Transradial PCI and Same Day Discharge.

    Science.gov (United States)

    Elfandi, Ali; Safirstein, Jordan G

    2018-02-24

    The evolution of cardiac catheterization has led to the development of well-refined, more effective, and safer devices that allow cardiovascular interventionalists to deliver high-quality percutaneous interventions (PCI). Transradial PCI (TRI) has gained more popularity in the USA over the past 10 years, and as experience and volume of TRI grow, studies adopting same day radial PCI protocols have emerged and are showing promising results. We sought to review the current literature on TRI and same day discharge (SDD). This literature review was performed to evaluate the studies that were published over the last 17 years regarding TRI and SDD. A literature search using PubMed, Cochran database, Google Scholar, and Embase was performed for studies evaluating TRI and SDD from January 1, 2000, to August 1, 2017. Observational studies, randomized clinical trials, meta-analyses, and consensus statements were included in our review. We used the following terms in our search: "same day," "same day discharge," "outpatient," and "ambulatory radial PCI." Articles with data pertinent to the subject matter were included. We did not limit our searches to specific journals. The available literature supports SDD for selected radial PCI patients. The advancement in PCI devices and pharmacology has enhanced the safety of post-PCI disposition leading to the evolution from traditional overnight stays to the development of same day discharge programs. We conclude that outpatient TRI for appropriately selected patients will be the standard of care in the future. This will lead to increased patient satisfaction, improved hospital throughput, and reduced hospital costs, without increased procedural complications.

  19. Associations Between Complex PCI and Prasugrel or Clopidogrel Use in Patients With Acute Coronary Syndrome Who Undergo PCI: From the PROMETHEUS Study.

    Science.gov (United States)

    Chandrasekhar, Jaya; Baber, Usman; Sartori, Samantha; Aquino, Melissa; Kini, Annapoorna S; Rao, Sunil; Weintraub, William; Henry, Timothy D; Farhan, Serdar; Vogel, Birgit; Sorrentino, Sabato; Ge, Zhen; Kapadia, Samir; Muhlestein, Joseph B; Weiss, Sandra; Strauss, Craig; Toma, Catalin; DeFranco, Anthony; Effron, Mark B; Keller, Stuart; Baker, Brian A; Pocock, Stuart; Dangas, George; Mehran, Roxana

    2018-03-01

    Potent P2Y 12 inhibitors might offer enhanced benefit against thrombotic events in complex percutaneous coronary intervention (PCI). We examined prasugrel use and outcomes according to PCI complexity, as well as analyzing treatment effects according to thienopyridine type. PROMETHEUS was a multicentre observational study that compared clopidogrel vs prasugrel in acute coronary syndrome patients who underwent PCI (n = 19,914). Complex PCI was defined as PCI of the left main, bifurcation lesion, moderate-severely calcified lesion, or total stent length ≥ 30 mm. Major adverse cardiac events (MACE) were a composite of death, myocardial infarction, stroke, or unplanned revascularization. Outcomes were adjusted using multivariable Cox regression for effect of PCI complexity and propensity-stratified analysis for effect of thienopyridine type. The study cohort included 48.9% (n = 9735) complex and 51.1% (n = 10,179) noncomplex patients. Second generation drug-eluting stents were used in 70.1% complex and 66.2% noncomplex PCI patients (P PCI was associated with greater adjusted risk of 1-year MACE (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.20-1.39; P PCI patients (P = 0.30). Compared with clopidogrel, prasugrel significantly decreased adjusted risk for 1-year MACE in complex PCI (HR, 0.79; 95% CI, 0.68-0.92) but not noncomplex PCI (HR, 0.91; 95% CI, 0.77-1.08), albeit there was no evidence of interaction (P interaction = 0.281). Despite the use of contemporary techniques, acute coronary syndrome patients who undergo complex PCI had significantly higher rates of 1-year MACE. Adjusted magnitude of treatment effects with prasugrel vs clopidogrel were consistent in complex and noncomplex PCI without evidence of interaction. Copyright © 2018. Published by Elsevier Inc.

  20. Superior long term outcome associated with native vessel versus graft vessel PCI following secondary PCI in patients with prior CABG.

    Science.gov (United States)

    Mavroudis, Chrysostomos A; Kotecha, Tushar; Chehab, Omar; Hudson, Jonathan; Rakhit, Roby D

    2017-02-01

    Secondary percutaneous coronary intervention (PCI) in patients with prior coronary artery bypass graft surgery is increasingly common. Graft vessel PCI has higher rates of adverse events compared with native coronary vessel PCI. To investigate the clinical outcomes of patients with prior CABG who underwent secondary PCI of either a graft vessel (GV), a native coronary vessel (NV) or both graft and native (NG) vessels. 220 patients (84% male) who underwent PCI in our institution to either GV (n=89), NV (n=103) or both GV and NV (NG group) (n=28) were studied. The study population underwent 378 procedures (GV group; n=126, NV group; n=164 and NG group; n=88). Median follow up was for 36months [range 2-75months]. Target vessel revascularisation (TVR) occurred in 12.5% of the GV group and 3.6% in the NV group [p=0.0004], and was predominantly due to in-stent restenosis. Patients who had PCI due to TVR were more likely to suffer from diabetes and peripheral vascular disease. History of chronic renal failure was associated with higher risk (HR 2.21, p=0.005) whereas preserved left ventricular ejection fraction (LVEF) with lower risk (HR 0.17, p=0.0007) of death. The median survival (interval between CABG and end of follow-up period) was lower in the GV compared with the NV group (315 vs 372months p=0.005). This registry demonstrates inferior long term outcome for patients undergoing secondary PCI of GV versus NV. Where possible, a strategy of NV rather than GV target PCI should be considered in patients with prior CABG. Secondary PCI in patients with prior CABG surgery is increasingly common. Graft vessel PCI has inferior outcomes with high rates of restenosis and occlusion compared with native coronary vessel PCI. We studied the clinical outcomes of 220 patients with prior CABG who underwent secondary PCI to either a graft vessel (GV), a native coronary vessel (NV) or both graft and native (NG) vessels. Target vessel revascularisation was 5 times higher in the GV

  1. PCI Compliance Understand and Implement Effective PCI Data Security Standard Compliance

    CERN Document Server

    Chuvakin, Anton

    2010-01-01

    Identity theft and other confidential information theft have now topped the charts as the #1 cybercrime. In particular, credit card data is preferred by cybercriminals. Is your payment processing secure and compliant?. Now in its second edition, PCI Compliance has been revised to follow the new PCI DSS standard 1.2.1. Also new to this edition: Each chapter has how-to guidance to walk you through implementing concepts, and real-world scenarios to help you relate to the information and better grasp how it impacts your data. This book provides the information that you need to understand the curre

  2. Antiplatelet therapy in PCI

    Science.gov (United States)

    Fanaroff, Alexander; Rao, Sunil

    2018-01-01

    Platelets play a key role in mediating stent thrombosis, the major cause of ischemic events in the immediate period following percutaneous coronary intervention (PCI). For this reason, antiplatelet therapy, started at the time of PCI and continued for at least 30 days afterwards, is the cornerstone of antithrombotic therapy after PCI. However, the use of antiplatelet agents increase bleeding risk, with more potent antiplatelet agents further increasing bleeding risk. For this reason, balancing prevention of ischemic events with risk of bleeding is fundamental to the effective use of antiplatelet agents. In the past 5 years, potent and fast-acting P2Y12 inhibitors have been introduced, and have augmented the antiplatelet armamentarium available to interventional cardiologists. In this review, we review the preclinical and clinical data surrounding these new agents, and discuss the significant questions and controversies that still exist regarding the optimal antiplatelet strategy. PMID:28582206

  3. Verkkokauppa PCI DSS - standardin mukaiseksi : case Scandinavian Outdoor

    OpenAIRE

    Kiiski, Tomi

    2015-01-01

    Tämän opinnäytetyön tavoitteena on selvittää, mitä toimia verkkokaupalta vaaditaan PCI DSS - standardin mukaisuuteen sekä mikä PCI DSS -standardi on ja mitä se sisältää. Työn toimeksiantaja on Scandinavian Outdoor Oy. Toimeksiantajan edellinen PCI DSS -auditointi on suoritettu standardin vanhalla versiolla ja standardista on nyt uusi versio. Työn teoriaosa käsittelee yleisesti PCI DSS -standardia, sen sisältöä sekä vaatimuksia. Työn tärkeimpänä lähteenä on käytetty PCI SSC:n ju...

  4. MANAJEMEN PENGELOLAAN WAHANA REKREASI OLAHRAGA DI WISATA WATER BLASTER SEMARANG TAHUN 2013

    Directory of Open Access Journals (Sweden)

    Mochamad Syahroni Firdiansyah

    2015-02-01

    Full Text Available This study aims to determine the process and the management of existing resources in the recreational vehicle Blaster Water sports in Semarang . This study is a qualitative research methodology . Collecting data using observation , questionnaires , interviews , documents and documentation . The data analysis technique used is descriptive percentage ( DP and the method of triangulation . The results of a descriptive study using a percentage , obtained planning process including criteria results 75 % higher , organizing the results obtained 76.3 % including high criteria , the results obtained leadership criteria included a low 53.8 % , controls 83.8 % obtained results are included in the very high criteria . Human resources results obtained 68.8 % including high criteria , the results obtained infrastructure including high criteria 74.6 % , 61.0 % of funds obtained results include lower criteria , and marketing of 70.3 % obtained results including high criteria . The conclusions in this study are the sights properly implement management processes .

  5. La prolusione di rocco e le dottrine del processo penale

    OpenAIRE

    Renzo Orlandi

    2015-01-01

    L’articolo analizza le conseguenze del pensiero giuridico di Arturo Rocco, dal 1910 nella dottrina di procedura penale, ossia, il metodo tecnico-giuridico (esegesi, sistematica e critica). La dogmatica di procedura pena- le inizia con la monografia di Giovanni Conso, nel 1955. L’insoddisfazione con il tecnicismo giuridico e con la mancanza di maturità scientifica si è manifestata con Carnelutti nel 1946 (Cerenterola), sottolineando le peculiarità strutturali del procedimento penale. In questa...

  6. Predictors of Interventional Success of Antegrade PCI for CTO.

    Science.gov (United States)

    Luo, Chun; Huang, Meiping; Li, Jinglei; Liang, Changhong; Zhang, Qun; Liu, Hui; Liu, Zaiyi; Qu, Yanji; Jiang, Jun; Zhuang, Jian

    2015-07-01

    This study aimed to identify significant lesion features of chronic total occlusions (CTOs) that predict failure of antegrade (A) percutaneous coronary intervention (PCI) using pre-procedure coronary computed tomography angiography (CTA) combined with conventional coronary angiography (CCA). The current predictors of successful A-PCI in the setting of CTOs are uncertain. Such knowledge might prompt early performance of a retrograde (R)-PCI approach if predictors of A-PCI failure are present. Consecutive patients confirmed to have at least 1 CTO of native coronary arteries underwent coronary CTA- and CCA-guided PCI in which computed tomography and fluoroscopic images were placed side by side before or during PCI. The study included 103 patients with 108 CTOs; 80 lesions were successfully treated with A-PCI and 28 lesions failed this approach, for an A-PCI success rate of 74%. A total of 15 of 28 failed cases underwent attempted R-PCI. Only 1 case also failed R-PCI; thus, the total PCI success rate was 87%. By multivariable analysis, the factors significantly predictive of failed A-PCI included negative remodeling (odds ratio [OR]: 137.82) and lesion length >31.89 mm on coronary CTA (OR: 7.04), and ostial or bifurcation lesions on CCA (OR: 8.02). R-PCI was successful in 14 of 15 patients (93.3%), in whom good appearance of the occluded distal segment and well-developed collateral vessels were present. Morphologic predictors of failed A-PCI on the basis of pre-procedure coronary CTA and CCA imaging may be identified, which may assist in determining which patients with CTO lesions would benefit from an early R-PCI strategy. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  7. PCI hardware support in LIA-2 control system

    International Nuclear Information System (INIS)

    Bolkhovityanov, D.; Cheblakov, P.

    2012-01-01

    The control system of the LIA-2 accelerator is built on cPCI crates with *86- compatible processor boards running Linux. Slow electronics is connected via CAN-bus, while fast electronics (4 MHz and 200 MHz fast ADCs and 200 MHz timers) are implemented as cPCI/PMC modules. Several ways to drive PCI control electronics in Linux were examined. Finally a user-space drivers approach was chosen. These drivers communicate with hardware via a small kernel module, which provides access to PCI BARs and to interrupt handling. This module was named USPCI (User-Space PCI access). This approach dramatically simplifies creation of drivers, as opposed to kernel drivers, and provides high reliability (because only a tiny and thoroughly-debugged piece of code runs in kernel). LIA-2 accelerator was successfully commissioned, and the solution chosen has proven adequate and very easy to use. Besides, USPCI turned out to be a handy tool for examination and debugging of PCI devices direct from command-line. In this paper available approaches to work with PCI control hardware in Linux are considered, and USPCI architecture is described. (authors)

  8. Preventive PCI versus culprit lesion stenting during primary PCI in acute STEMI: a systematic review and meta-analysis

    Science.gov (United States)

    Pandit, Anil; Aryal, Madan Raj; Aryal Pandit, Aashrayata; Hakim, Fayaz Ahmad; Giri, Smith; Mainali, Naba Raj; Sharma, Prashant; Lee, Howard R; Fortuin, F David; Mookadam, Farouk

    2014-01-01

    Aim The benefit of preventive percutaneous coronary intervention (PCI) in ST elevation myocardial infarction (STEMI) has been shown in randomised trials. However, all the randomised trials are underpowered to detect benefit in cardiac death. We aim to systematically review evidence on the cardiac mortality benefit of preventive PCI in patients presenting with acute STEMI in randomised patient populations. Methods PubMed, Scopus, Cochrane and clinicaltrials.gov databases were searched for studies published until 30 September 2013. The studies were limited to randomised clinical trials. Independent observers abstracted the data on outcomes, characteristics and qualities of studies included. Fixed effect model was employed for meta-analysis. Heterogeneity of studies included was analysed using I2 statistics. Results In three randomised clinical trials published, involving 748 patients with acute STEMI and multivessel disease, 416 patients were randomised to preventive PCI and 332 to culprit-only PCI. Patients undergoing preventive PCI had significant lower risk of cardiovascular deaths (pooled OR 0.39, 95% CI 0.18 to 0.83, p=0.01, I2=0%), repeat revascularisation (pooled OR 0.28, 95% CI 0.18 to 0.44, p=0.00001, I2=0%) and non-fatal myocardial infarction (pooled OR 0.38, 95% CI 0.20 to 0.75, p=0.005, I2=0%) compared with culprit-only revascularisation. Conclusions In patients presenting with acute STEMI and significant multivessel coronary artery disease, based on our data, preventive PCI is associated with lower risk of cardiovascular mortality compared with primary PCI of only the culprit artery. This finding needs to be confirmed in larger adequately powered randomised clinical trials. PMID:25332779

  9. En un lugar del aula… De lo que le sucedió a don Quijote en una clase de E/LE

    Directory of Open Access Journals (Sweden)

    Luz Celestina Souto

    2017-11-01

    Full Text Available Resumen: El presente trabajo tiene como objetivo mostrar una vía para la lectura de El ingenioso hidalgo don Quijote de la Mancha en el aula de E/LE. La propuesta se realizará a través de una selección de recursos y actividades sobre el clásico de Cervantes. Las preguntas desde las cuales se parte para el planteamiento son: ¿Qué es un clásico? ¿Por qué leer a Cervantes en la clase de E/LE? ¿Cómo leerlo? ¿Qué ventajas tiene El Quijote en el siglo xxi para quienes tienen el español como segunda lengua? Palabras Clave: Siglo de Oro, Quijote, clase de E/LE, literatura   Abstract: The present work aims to show a way to read El ingenioso hidalgo don Quijote de la Mancha in the E/LE class. The proposal is made through a selection of resources and activities about Cervantes. The questions we ask are: what is a classic? Why read Cervantes in E/LE class? How to read it? What are advantages of  El Quijote in the 21st century for those who have Spanish as a second language? Keywords: Spanish Golden Age, Quixote, E/LE class, literature

  10. Predictors of subjective health status 10 years post-PCI.

    Science.gov (United States)

    van den Berge, Jan C; Dulfer, Karolijn; Utens, Elisabeth M W J; Hartman, Eline M J; Daemen, Joost; van Geuns, Robert J; van Domburg, Ron T

    2016-06-01

    Subjective health status is an increasingly important parameter to assess the effect of percutaneous coronary intervention (PCI) in clinical practice. Aim of this study was to determine medical and psychosocial predictors of poor subjective health status over a 10 years' post-PCI period. We included a series of consecutive PCI patients (n = 573) as part of the RESEARCH registry, a Dutch single-center retrospective cohort study. These patients completed the 36-item Short-Form Health Survey (SF-36) at baseline and 10 years post-PCI. We found 6 predictors of poor subjective health status 10 years post-PCI: SF-36 at baseline, age, previous PCI, obesity, acute myocardial infarction as indication for PCI, and diabetes mellitus (arranged from most to least numbers of sub domains). SF-36 scores at baseline, age, and previous PCI were significant predictors of subjective health status 10 years post-PCI. Specifically, the SF-36 score at baseline was an important predictor. Thus assessment of subjective health status at baseline is useful as an indicator to predict long-term subjective health status. Subjective health status becomes better by optimal medical treatment, cardiac rehabilitation and psychosocial support. This is the first study determining predictors of subjective health status 10 years post-PCI.

  11. Controversies in the treatment of patients with STEMI and multivessel disease: is it time for PCI of all lesions?

    Science.gov (United States)

    Ong, Peter; Sechtem, Udo

    2016-06-01

    Several randomized trials have suggested a benefit for multivessel PCI in patients with STEMI and multivessel disease. However, none of the studies compared multivessel PCI with a staged PCI-approach which is the current guideline recommended approach. The results of the trials may overestimate the beneficial effect of the multivessel PCI approach because the control group did not receive any ischaemia testing for evaluation of the significance of remaining lesions. Thus, unfavourable aspects of the multivessel PCI approach such as overestimation of non-culprit lesions at the time of acute coronary angiography, complications associated with PCI of the non-culprit lesion (i.e. dissection, no-reflow, acute stent thrombosis) or increased risk for contrast induced nephropathy may have gone unnoticed as the comparative management pathway was unusual and likely inferior to the guideline recommended approach. We believe that culprit lesion only PCI and staged evaluation of remaining areas of myocardial ischaemia with subsequent PCI is still preferable in patients with STEMI and multivessel disease but a randomized study comparing this approach with multivessel PCI is needed.

  12. PCI-OGRAMS: application of CANDU fuelogram methodology to PCI data from light water reactors

    International Nuclear Information System (INIS)

    Wood, J.C.

    1979-01-01

    The FUELOGRAM model was derived to predict PCI defect probablilities for CANDU fuel bundles that had experienced power increases after being irradiated to burnups mostly in the range 100 +- 60 MW.h/kg U. It is inappropriate to extrapolate the FUELOGRAM model to predict the performance of differently designed fuels at burnups up to 600 MW.h/kg U Therefore data obtained from the operaton of a Boiling Water Reactor were analyzed using the FUELOGRAM methodology to assess fuel performance criteria at high burnups. The resultant PCI-OGRAMS evaluate defect probabilities in terms of power increase (ΔP), ramped power (P), and the burnup (ω) of the most highly rated rod in a fuel assembly. Defect probability also depends on the dwell time (t), of fuel at the ramped power. The predictions of the PCI-OGRAM, FUELOGRAM and other models are compared in three-dimensional sketches of P, ΔP, and ω with the dwell time t held constant. (author)

  13. La prolusione di rocco e le dottrine del processo penale

    Directory of Open Access Journals (Sweden)

    Renzo Orlandi

    2015-03-01

    Full Text Available L’articolo analizza le conseguenze del pensiero giuridico di Arturo Rocco, dal 1910 nella dottrina di procedura penale, ossia, il metodo tecnico-giuridico (esegesi, sistematica e critica. La dogmatica di procedura pena- le inizia con la monografia di Giovanni Conso, nel 1955. L’insoddisfazione con il tecnicismo giuridico e con la mancanza di maturità scientifica si è manifestata con Carnelutti nel 1946 (Cerenterola, sottolineando le peculiarità strutturali del procedimento penale. In questa prospettiva, il testo sottolinea la conferenza di Franco Cordero nel 1964 (Lecce, così come le lezioni da James Goldschmidt. Inoltre, negli anni sessanta, divennero importanti diritti fondamentali, di fronte alla Costituzione democratica, con un nuovo orientamento dottrinale. Il diritto processuale penale è stato considerato come diritto costituzionale applicato. Si segnalano gli insegnamenti di Amodio, Amato, Chiavario, Ferrua, Grevi, Iluminati, Massa e Nobili. Successivamente, l’articolo mette in evidenza il CPP del 1988, l’internazionalizzazione dei sistemi giuridici, l’importanza del diritto comparato e dei diritti fondamentali. Si conclude con il nuovo ordine mondiale dei diplomi internazionali e tribunali sovranazionali, con nuove esigenze, oltre il tecnicismo giuridico.

  14. An overview of PCI in the very elderly

    Science.gov (United States)

    Shanmugam, Vimalraj Bogana; Harper, Richard; Meredith, Ian; Malaiapan, Yuvaraj; Psaltis, Peter J

    2015-01-01

    Cardiovascular disease, and in particular ischemic heart disease (IHD), is a major cause of morbidity and mortality in the very elderly (> 80 years) worldwide. These patients represent a rapidly growing cohort presenting for percutaneous coronary intervention (PCI), now constituting more than one in five patients treated with PCI in real-world practice. Furthermore, they often have greater ischemic burden than their younger counterparts, suggesting that they have greater scope of benefit from coronary revascularization therapy. Despite this, the very elderly are frequently under-represented in clinical revascularization trials and historically there has been a degree of physician reluctance in referring them for PCI procedures, with perceptions of disappointing outcomes, low success and high complication rates. Several issues have contributed to this, including the tendency for older patients with IHD to present late, with atypical symptoms or non-diagnostic ECGs, and reservations regarding their procedural risk-to-benefit ratio, due to shorter life expectancy, presence of comorbidities and increased bleeding risk from antiplatelet and anticoagulation medications. However, advances in PCI technology and techniques over the past decade have led to better outcomes and lower risk of complications and the existing body of evidence now indicates that the very elderly actually derive more relative benefit from PCI than younger populations. Importantly, this applies to all PCI settings: elective, urgent and emergency. This review discusses the role of PCI in the very elderly presenting with chronic stable IHD, non ST-elevation acute coronary syndrome, and ST-elevation myocardial infarction. It also addresses the clinical challenges met when considering PCI in this cohort and the ongoing need for research and development to further improve outcomes in these challenging patients. PMID:25870621

  15. Être et exister: le cas de La Nausée

    Directory of Open Access Journals (Sweden)

    Maarten van Buuren

    2007-06-01

    Le trajet de La Nausée est un trajet descendant, comparable à Mort à venise. Celui de L’Etre et le Néant est un trajet ascendant comparable à La Montagne magique. Par rapport à L’Etre et le Néant qui décrit l’extase triomphante de l’esprit, La Nausée se dessine comme l’étape précédente: celle de la descente en enfer.

  16. The inherent catastrophic traps in retrograde CTO PCI.

    Science.gov (United States)

    Wu, Eugene B; Tsuchikane, Etsuo

    2018-05-01

    When we learn to drive, our driving instructor tells us how to check the side mirror and turn your head to check the blind spot before changing lanes. He tells us how to stop at stop signs, how to drive in slippery conditions, the safe stopping distances, and these all make our driving safe. Similarly, when we learn PCI, our mentors teach us to seat the guiding catheter co-axially, to wire the vessel safely, to deliver balloon and stents over the wire, to watch the pressure of the guiding, in order that we perform PCI safely and evade complications. In retrograde CTO PCI, there is no such published teaching. Also many individual mentors have not had the wide experience to see all the possible complications of retrograde CTO PCI and, therefore, may not be able to warn their apprentice. As the number of retrograde procedures increase worldwide, there is a corresponding increase in catastrophic complications, many of which, we as experts, can see are easily avoidable. To breach this gap in knowledge, this article describes 12 commonly met inherent traps in retrograde CTO PCI. They are inherent because by arranging our equipment in the manner to perform retrograde CTO PCI, these complications are either induced directly or happen easily. We hope this work will enhance safety of retrograde CTO PCI and avoid many catastrophic complications for our readers and operators. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  17. PCI-SS: MISO dynamic nonlinear protein secondary structure prediction

    Directory of Open Access Journals (Sweden)

    Aboul-Magd Mohammed O

    2009-07-01

    Full Text Available Abstract Background Since the function of a protein is largely dictated by its three dimensional configuration, determining a protein's structure is of fundamental importance to biology. Here we report on a novel approach to determining the one dimensional secondary structure of proteins (distinguishing α-helices, β-strands, and non-regular structures from primary sequence data which makes use of Parallel Cascade Identification (PCI, a powerful technique from the field of nonlinear system identification. Results Using PSI-BLAST divergent evolutionary profiles as input data, dynamic nonlinear systems are built through a black-box approach to model the process of protein folding. Genetic algorithms (GAs are applied in order to optimize the architectural parameters of the PCI models. The three-state prediction problem is broken down into a combination of three binary sub-problems and protein structure classifiers are built using 2 layers of PCI classifiers. Careful construction of the optimization, training, and test datasets ensures that no homology exists between any training and testing data. A detailed comparison between PCI and 9 contemporary methods is provided over a set of 125 new protein chains guaranteed to be dissimilar to all training data. Unlike other secondary structure prediction methods, here a web service is developed to provide both human- and machine-readable interfaces to PCI-based protein secondary structure prediction. This server, called PCI-SS, is available at http://bioinf.sce.carleton.ca/PCISS. In addition to a dynamic PHP-generated web interface for humans, a Simple Object Access Protocol (SOAP interface is added to permit invocation of the PCI-SS service remotely. This machine-readable interface facilitates incorporation of PCI-SS into multi-faceted systems biology analysis pipelines requiring protein secondary structure information, and greatly simplifies high-throughput analyses. XML is used to represent the input

  18. Timing of intervention in high-risk non-ST-elevation acute coronary syndromes in PCI versus non-PCI centres : Sub-group analysis of the ELISA-3 trial.

    Science.gov (United States)

    Badings, E A; Remkes, W S; Dambrink, J-H E; The, S H K; Van Wijngaarden, J; Tjeerdsma, G; Rasoul, S; Timmer, J R; van der Wielen, M L J; Lok, D J A; van 't Hof, A W J

    2016-03-01

    To compare the effect of timing of intervention in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) in percutaneous coronary intervention (PCI) versus non-PCI centres. A post-hoc sub-analysis was performed of the ELISA III trial, a randomised multicentre trial investigating outcome of early ( 48 h) angiography and revascularisation in 542 patients with high-risk NSTE-ACS. 90 patients were randomised in non-PCI centres and tended to benefit more from an early invasive strategy than patients included in the PCI centre (relative risk 0.23 vs. 0.85 [p for interaction = 0.089] for incidence of the combined primary endpoint of death, reinfarction and recurrent ischaemia after 30 days of follow-up). This was largely driven by reduction in recurrent ischaemia. In non-PCI centres, patients randomised to the late group had a 4 and 7 day longer period until PCI or coronary artery bypass grafting, respectively. This difference was less pronounced in the PCI centre. This post-hoc analysis from the ELISA-3 trial suggests that NSTE-ACS patients initially hospitalised in non-PCI centres show the largest benefit from early angiography and revascularisation, associated with a shorter waiting time to revascularisation. Improved patient logistics and transfer between non-PCI and PCI centres might therefore result in better clinical outcome.

  19. Editorial L&E, v.7, n.1, 2013.

    Directory of Open Access Journals (Sweden)

    Rede Conpadre

    2013-02-01

    Full Text Available Editorial L&E, v.7, n.1, 2013 L’architettura, in quanto bene d’uso, è da considerarsi come un’opera aperta, destinata a venire, nel corso della sua esistenza, modificata, trasformata, integrata per poter continuare ad essere utilizzata e fruita. Le architetture che sono state oggetto di dismissione, a seguito del venir meno delle motivazioni (funzioni per le quali esse erano state realizzate, sono, più di altre, destinate a subire tali trasformazioni. Sono, infatti, architetture ormai deboli e fragili, nella maggior parte dei casi considerate prive di valore o quasi, che proprio in virtù di queste considerazioni vengono abbandonate e/o distrutte, decretandone irrimediabilmente la scomparsa. Il patrimonio industriale dismesso rientra a pieno titolo in tale categoria di manufatti architettonici e, purtroppo, nel corso del tempo, è stato sottoposto a qualsivoglia tipo di manomissione, ivi compresa la demolizione. Si tratta però di un patrimonio che, a ben guardare, risulta ancora ricco di qualità e di potenzialità che potrebbe/dovrebbe essere adeguatamente valorizzato attraverso lo studio e la messa a punto di soluzioni che consentano di massimizzare la permanenza, pur prestando attenzione al problema della sostenibilità degli interventi sia in fase di realizzazione degli stessi, sia in fase di utilizzo dei beni sottoposti ai necessari e appropriati interventi di rifunzionalizzazione. Solo in questo modo tale patrimonio può cessare di rappresentare un “problema” per i proprietari, pubblici o privati che siano, per divenire una risorsa – architettonica, culturale e, perché no, anche materiale – garantendone la permanenza nel tempo – magari trasformata, sicuramente arricchita da nuove tracce – e la trasmissione alle future generazioni. Manuela Mattone

  20. Pronunciación y TIC en el aula de E/LE

    Directory of Open Access Journals (Sweden)

    Nuria Escrig Teixeira

    2016-11-01

    Full Text Available El objetivo de la siguiente experiencia práctica es presentar y describir dos aplicaciones con las que trabajar la pronunciación en el aula de E/LE: Adobe Voice y Dragon Dictation. Mediante estas dos herramientas podemos desarrollar las cuatro habilidades de la lengua (comprensión lectora, expresión escrita, comprensión oral y expresión oral, aplicar los contenidos explicados en cualquier nivel, introducir las TIC en clase y practicar la pronunciación, materia un poco olvidada en el aula. Por ello, se realizará una descripción de las aplicaciones y de las posibilidades didácticas para explotar su uso en clase.   Palabras clave: aplicaciones, pronunciación, E/LE, posibilidades didácticas.   Pronunciation and ICT in E/LE class   Abstract: The objetive of the following experience is to introduce and describe two apps to work the pronunciation in E/LE class: Adobe Voice and Dragon Dictation. Through this apps the four comuniucation skills (speaking, listening, writing and reading are developed in any level and the ICT are introduced in a way we can practise the pronunciation, forgotten subject in class. For that reason, we will describe the apps and their didactic possibilities to use.   Keywords: apps, pronunciation, E/LE, didactic possibilities.

  1. Condition Assessment of PCI Bridge Girder a Result of The Reduction Prestressing Force

    Directory of Open Access Journals (Sweden)

    Suangga Made

    2014-03-01

    Full Text Available PCI bridge girders is known and widely used for many construction e.g.: bridge, wharf, flyover, and other application. PC Bridge girders have two types: Pre - tensioned girders and post - tensioned girders. In pre tensioned girders, prestressing in carried out first then after that the fresh concrete poured. The prestressing process in only carried off after the concrete has sufficient strength. In this study, analysis was conducted for PCI bridge girder with span is 40 meters. Based on the data geometry bridge dimension girder, material girder, and material strands cable, it will be analyzed to calculate the natural frequencies and moment capacity using finite element program (Midas/Civil program. So it can be estimated how much the percentage reduction prestress force on the bridge until PCI bridge structure collapses. From the calculation, it found that the pattern comparison between reduction prestressing force and natural frequency are linear. These results are also similar for natural frequency versus moment capacity.PCI bridge will collapse when the reduction prestreesing force of 45 % to 50 % from the total loss of prestressing.

  2. A millennium approach to data acquisition: SCI and PCI

    International Nuclear Information System (INIS)

    Mueller, Hans; Bogaerts, A.; Lindenstruth, V.

    1996-01-01

    The international SCI standard IEEE/ANSI 1596 a is on its way to become the computer interconnect of the year 2000 since for a first time, low latency desktop multiprocessing and cluster computing can be implemented at low cost. The PCI bus is todays's dominating local bus extension for all major computer platforms as well as buses like VMEbus. PCI is a self configuring memory and I/O system for peripheral components with a hierarchical architecture. SCI is a scalable, bus-like interconnect for distributed processors and memories. It allows for optionally coherent data caching and assures error free data delivery. First measurement with commercial SCI products (SBUS-SCI) confirm simulations that SCI can handle even the highest data rates of LHC experiments. The event builder layer for a millennium very high rate DAQ system can therefore be viewed as a SCI network (bridges, cables and switches) interfaced between PCI buses on the front end (VME b ) side and on the processor farm Multi-CPU) side. Such a combination of SCI and PCI enables PCI-PCI memory access, transparently across SCI. It also allows for a novel, low level trigger technique: the trigger algorithm can access VME data buffers with bus-like latencies like local memory, full data transfers become redundant. The first prototype of a PCI-SCI bridge for DAQ is presented as starting point for a test system with built-in scalability. (author)

  3. Curtis E. LeMay: A Great Warrior

    Science.gov (United States)

    1984-04-01

    Continue On F& Veta . sid~ e Of necessary and Identify hr block number) - Roview, analysis and comparison of Curtis E.Lemay’s strategy ir Europe and the...000 AIR COMMAND AND STAFF COLLEGE STUDENT REPORT, . CURTIS E . LE-MAY A GREAT WARRIORi’ l MAVO IAN . ROBINSON 84,-2190 -AUG 1 0 1984 • "’insights into...tomorrow" E ,,=IL i ’,’ ....... -" -- 84 08 08 03 ~032 DISCLAIMER The views and conclusions expressed in this document are those of the author. They

  4. El uso del diccionario en el aula de E/LE: problemas y posibles soluciones

    Directory of Open Access Journals (Sweden)

    Antoni Nomdedeu Rull

    2012-08-01

    Full Text Available En este estudio, parto de la base de que, por un lado, no todos los estudiantes deE/LE de un mismo nivel tienen las mismas necesidades, al intervenir diferentesvariables que permiten diferenciar a un estudiante de otro; por otro lado, es necesarioemplear el diccionario como herramienta de aprendizaje activo y autónomo del léxicode E/LE. Para ello, y a partir de mis experiencias prácticas en el aula sobre el uso deldiccionario monolingüe de aprendizaje de E/LE (DIMAELE con estudiantes italianosde E/LE, presentaré, en primer lugar, una breve justificación sobre su uso en el aula. Ensegundo lugar, expondré la idea argumentada de que los DIMAELE existentes debenmejorar la representación de las informaciones que contienen, para lo cual me centraréen las relativas a los sinónimos. En tercer lugar, me referiré a la perspectiva delestudiante de E/LE por medio de una investigación (Campanile et al., 2011, que hecoordinado, sobre falsos amigos realizada por mis ex-estudiantes italianos de E/LE en laque indican qué informaciones de los DIMAELE les resultan útiles y cuáles, de lasútiles, no aparecen en dichos repertorios.

  5. El uso del diccionario en el aula de E/LE: problemas y posibles soluciones

    Directory of Open Access Journals (Sweden)

    Antoni Nomdedeu Rull

    2011-01-01

    Full Text Available En este estudio, parto de la base de que, por un lado, no todos los estudiantes de E/LE de un mismo nivel tienen las mismas necesidades, al intervenir diferentes variables que permiten diferenciar a un estudiante de otro; por otro lado, es necesario emplear el diccionario como herramienta de aprendizaje activo y autónomo del léxico de E/LE. Para ello, y a partir de mis experiencias prácticas en el aula sobre el uso del diccionario monolingüe de aprendizaje de E/LE (DIMAELE con estudiantes italianos de E/LE, presentaré, en primer lugar, una breve justificación sobre su uso en el aula. En segundo lugar, expondré la idea argumentada de que los DIMAELE existentes deben mejorar la representación de las informaciones que contienen, para lo cual me centraré en las relativas a los sinónimos. En tercer lugar, me referiré a la perspectiva del estudiante de E/LE por medio de una investigación (Campanile et al., 2011, que he coordinado, sobre falsos amigos realizada por mis ex-estudiantes italianos de E/LE en la que indican qué informaciones de los DIMAELE les resultan útiles y cuáles, de las útiles, no aparecen en dichos repertorios.

  6. Une approche écosanté pour le contrôle de la fièvre de la vallée du ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 août 2016 ... Ces conclusions sont particulièrement pertinentes à la lumière des avancées récentes réalisées pour le vaccin contre la fièvre de la vallée du Rift et seront un important facteur à prendre en compte pour le moment de lancer le futur vaccin et la manière de le faire. Les tendances de mobilité du bétail ...

  7. Vocational Education Program/Course Inventory Form PCI. Explanation and Instructional Manual.

    Science.gov (United States)

    California Occupational Information Coordinating Committee, Sacramento.

    This manual for teachers, administrators, and counselors both explains the Program/Course Inventory (PCI), a data collection instrument, and provides instructions for completing the PCI form. The first section describes the PCI developed by the Ventura County Superintendent of Schools staff to collect data that define vocational education…

  8. 7,528 patients treated with PCI - a Scandinavian real-life scenario

    DEFF Research Database (Denmark)

    Pedersen, S.; Galatius, S.; Bech, J.

    2008-01-01

    AIM: Analyze clinical, temporal and procedural characteristics from 7,528 consecutive percutaneous coronary intervention (PCI) patients in one of the largest published contemporary European PCI-database during a 6-year period. METHOD: Retrospective study design. Period: 1998-2004. Temporal...... and referral changes in a Danish PCI-registry were analyzed. Demographic and angiographic variables were compared with data from randomized clinical trials, US-registries and current guidelines. RESULTS: 22,214 patients were examined with coronary angiography and 7,528 patients were treated with PCI....... The annual number of PCI's increased by 15%. Over time, the fraction of patients with risk factors increased, median age increased from 61 to 64 years and the coronary pathology was significantly worsened. ST-elevation myocardial infarction patients primarily admitted to hospitals without facilities...

  9. La crisi economica e la reciproca collaborazione tra le Chiese e lo Stato per “il bene del Paese”

    Directory of Open Access Journals (Sweden)

    Giuseppe Casuscelli

    2011-10-01

    Full Text Available SOMMARIO: 1. I principi in gioco – 2. I trattamenti preferenziali e le situazioni di vantaggio selettivo: ICI e otto per mille – 3. Per una lettura costituzionalmente orientata delle norme pattizie - 4. Il peculiare impegno della Chiesa cattolica e dello Stato alla reciproca collaborazione … – 5. (segue … per “il bene del Paese” – 6. Il finanziamento pubblico delle Chiese nei nuovi accordi … - 7. (segue e le “eventuali modifiche” dell’otto per mille – 8. Le vicende delle festività religiose "concordatarie" – 9. Il pluralismo confessionale, la laicità e l’uso controllato delle azioni positive – 10. Il magistero e la “profonda liberazione della Chiesa da forme di mondanità”.

  10. De Paris a Buenos Aires: imprensa, ideias e intelectuais no Le Monde Diplomatique

    Directory of Open Access Journals (Sweden)

    Juliana Sayuri Ogassawara

    2016-03-01

    Full Text Available Este artigo pretende expor as relações entre os intelectuais e jornalistas imbricados nas edições latino-americanas e a edição francesa do periódico Le Monde Diplomatique. Fundado em maio de 1954, em Paris, por Hubert Beuve-Méry, Le Monde Diplomatique viu suas páginas e suas ideias se alastrarem mundo afora – em 2013, o magazine tinha 47 edições internacionais, considerado um fenômeno único na imprensa mundial. Ao longo de sua trajetória, Le Monde Diplomatique teve sua linha editorial marcada por diretrizes politizadas, declaradamente antiimperialistas e antineoliberais. A tese desenvolvida focou a versão publicada em Buenos Aires, considerada a principal edição latino-americana, fundada por iniciativa do argentino Carlos Gabetta, diretor de Le Monde Diplomatique Edición Cono Sur entre 1999 e 2011. Ancorado na história dos intelectuais e na história do tempo presente, este artigo aborda as relações entre intelectuais franceses e argentinos na consolidação de uma experiência singular da imprensa.

  11. Algorithmes de reconstruction pour le filtrage en ligne et application à la mesure de la section efficace de la collision $e^{+}e^{-} \\to (e^{+}e^{-})\\eta$ c avec le système de digitalisation rapide pour la chambre à vertex de l'expérience L3

    CERN Document Server

    Forconi, G

    1993-01-01

    Algorithmes de reconstruction pour le filtrage en ligne et application à la mesure de la section efficace de la collision $e^{+}e^{-} \\to (e^{+}e^{-})\\eta$ c avec le système de digitalisation rapide pour la chambre à vertex de l'expérience L3

  12. PCISIM - A Simulation Tool for PCI Bus Based Systems

    DEFF Research Database (Denmark)

    Sharp, Robin

    1999-01-01

    This document describes a PCI bus simulator for use in evaluating the feasibility of system designs based on this bus.......This document describes a PCI bus simulator for use in evaluating the feasibility of system designs based on this bus....

  13. PCI in Patients Supported With CF-LVADs: Indications, Safety, and Outcomes.

    Science.gov (United States)

    Anyanwu, Emeka C; Ota, Takeyoshi; Sayer, Gabriel; Nathan, Sandeep; Jeevanandam, Valluvan; Shah, Atman; Uriel, Nir

    2016-06-01

    Patients with heart failure supported with left ventricular assist devices (LVADs) may require coronary intervention during their support. This case series seeks to explore the indications, safety, and outcomes of percutaneous coronary intervention (PCI) in this population. Electronic medical records of patients with LVADs undergoing PCI at a large academic medical center were reviewed. Demographics, reason for PCI, procedural success, complications, and outcomes were collected. From 2010-2014, a total of 6 patients underwent PCI post LVAD implantation. Three patients had PCI in the early postimplantation period (1-3 days post LVAD implantation) while the other three received it later in the LVAD support period. Three indications for PCI were found in the reviewed cases: right ventricular failure (right coronary artery stenting), bridge to left ventricular recovery, and ventricular tachycardia (VT) storm. All patients were maintained on triple blood thinning therapy (aspirin, clopidogrel, and warfarin). There were no acute complications during the interventions; however, 2 patients died in the early intervention period and 2 died much later. The 2 deaths in the early intervention period were related to fatal gastrointestinal bleeding while on dual-antiplatelet therapy and warfarin, and intractable VT that PCI did not correct. The 2 deaths in the late postintervention period occurred due to unknown causes nearly 1 and 2 years post intervention, respectively. PCI was performed in patients with continuous-flow LVAD with several possible indications and without acute complications. The utility of PCI in this patient population, however, is likely limited by the risk of bleeding related to combined antiplatelet and anticoagulation therapies as well as lack of immediate apparent benefit. Further studies are necessary to better characterize this risk as well as quantify any potential long-term benefits.

  14. Use and outcome of radial versus femoral approach for primary PCI in patients with acute ST elevation myocardial infarction without cardiogenic shock: results from the ALKK PCI registry.

    Science.gov (United States)

    Bauer, Timm; Hochadel, Matthias; Brachmann, Johannes; Schächinger, Volker; Boekstegers, Peter; Zrenner, Bernhard; Zahn, Ralf; Zeymer, Uwe

    2015-10-01

    This study sought to compare the use and outcome of radial versus femoral access in patients treated with primary percutaneous coronary intervention (PCI) for acute ST elevation myocardial infarction (STEMI) in clinical practice. The radial approach for PCI in patients with STEMI has been suggested to have a lower rate of complications and bleeding and to improve prognosis compared with the femoral approach. However, there still is a large regional and national variation in its use. Between 2008 and 2012 a total of 17,865 patients with STEMI without cardiogenic shock undergoing primary PCI were prospectively enrolled in the observational German PCI registry of the Arbeitsgemeinschaft leitende kardiologische Krankenhausärzte (ALKK). Transfemoral (TF) access was used in 15,270 (85.5%), transradial (TR) access in 2,530 (14.2%), and other access in 65 (0.3%) patients. In this analysis, 10,264 patients from 20 centers that had performed at least 5 TR-PCI for STEMI were included. This study compared TR-PCI (n = 2,454 23.9%) with TF-PCI (n = 7,810, 76.1%). Procedural success was high in both cohorts. Hospital mortality (1.8 vs. 5.1%, P PCI can be performed with excellent procedural success in selected STEMI patients and is associated with a lower rate of vascular access complications and hospital mortality. © 2015 Wiley Periodicals, Inc.

  15. RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer

    Science.gov (United States)

    He, Wei-Ling; Li, Yu-Huang; Hou, Wei-Jian; Ke, Zun-Fu; Chen, Xin-Lin; Lu, Li-Ya; Cai, Shi-Rong; Song, Wu; Zhang, Chang-Hua; He, Yu-Long

    2014-01-01

    AIM: To explore the efficacy of PCI-24781, a broad-spectrum, hydroxamic acid-derived histone deacetylase inhibitor, in the treatment of gastric cancer (GC). METHODS: With or without treatment of PCI-24781 and/or cis-diamminedichloroplatinum (CDDP), GC cell lines were subjected to functional analysis, including cell growth, apoptosis and clonogenic assays. Chromatin immunoprecipitation and luciferase reporter assays were used to determine the interacting molecules and the activity of the enzyme. An in vivo study was carried out in GC xenograft mice. Cell culture-based assays were represented as mean ± SD. ANOVA tests were used to assess differences across groups. All pairwise comparisons between tumor weights among treatment groups were made using the Tukey-Kramer method for multiple comparison adjustment to control experimental-wise type I error rates. Significance was set at P PCI-24781 significantly reduced the growth of the GC cells, enhanced cell apoptosis and suppressed clonogenicity, and these effects synergized with the effects of CDDP. PCI-24781 modulated the cell cycle and significantly reduced the expression of RAD51, which is related to homologous recombination. Depletion of RAD51 augmented the biological functions of PCI-24781, CDDP and the combination treatment, whereas overexpressing RAD51 had the opposite effects. Increased binding of the transcription suppressor E2F4 on the RAD51 promoter appeared to play a major role in these processes. Furthermore, significant suppression of tumor growth and weight in vivo was obtained following PCI-24781 treatment, which synergized with the anticancer effect of CDDP. CONCLUSION: These data suggest that RAD51 potentiates the synergistic effects of chemotherapy with PCI-24781 and CDDP on GC. PMID:25110436

  16. BIO-PCI, Charcoal injection in Blast Furnaces: State of the art and economic perspectives

    Directory of Open Access Journals (Sweden)

    Feliciano-Bruzual, C.

    2013-12-01

    Full Text Available The injection of grinded particles of charcoal through the tuyeres in Blast Furnaces, here coined Bio-PCI, presents as an attractive and plausible alternative to significantly reduce the CO2 emissions generated during hot metal production. In this contribution a summary of the technological fundaments, benefits and limitations of the incorporation of Bio-PCI is presented. Additionally the principal economic challenges of renewables fuel in ironmaking are exposed, with especial interest in the main productions costs of charcoal making. In this sense, a strategic question arises: can the residual biomass drive the emergence of Bio-PCI?, our analysis leads to conclude that the use of residual biomass (e.g. agricultural and forestry residues may significantly reduce the production cost in 120-180 USD/t in comparison to primary woods sources, this naturally increment the economical attractiveness of Bio-PCI substitution.La inyección de carbón vegetal por toberas en Altos Hornos, aqui denominada Bio-PCI, se presenta como una forma atractiva y realista de reducir significativamente las emisiones de CO2 generadas durante la producción de arrabio. En esta contribución se presenta un resumen de los fundamentos tecnológicos, los beneficios y las limitaciones de la incorporación de la tecnología del Bio-PCI. Adicionalmente se exponen los retos económicos que enfrentan los combustibles renovables a los fósiles, con especial interés en los principales costos de producción del carbón vegetal. En este sentido se plantea una pregunta estratégica: ¿puede la biomasa residual impulsar el desarrollo de la Bio-PCI?. Nuestro análisis conlleva a concluir que la utilización de biomasa residual (residuos forestales y agrícolas puede reducir sensiblemente el costo del carbón vegetal entre 120-180 USD/t en comparación con biomasa primaria, incrementando su competitividad frente al carbón mineral.

  17. Le reportage en bande dessinée dans la presse actuelle : un autre regard sur le monde

    Directory of Open Access Journals (Sweden)

    Séverine Bourdieu

    2012-05-01

    Full Text Available La bande dessinée sort de sa bulle et s’aventure du côté du réel, du documentaire et du factuel. À partir d’un corpus de reportages en bande dessinée parus dans des périodiques francophones au cours de la dernière décennie, nous nous interrogerons sur les enjeux de cette rencontre entre presse et littérature et sur la légitimité de ce genre en cours de constitution. On montrera ensuite que ce médium mixte, parce qu’il allie ressources graphiques et littéraires, est particulièrement approprié pour restituer à la fois la « chose vue » et l’expérience vécue par le reporter sur le terrain, offrant ainsi au lecteur un autre regard sur le monde.

  18. PCI Express Over Optical Links for Data Acquisition and Control

    CERN Document Server

    Bellato, M; Meng, G; Passaseo, M; Rampazzo, G; Triossi, A; Ventura, Sandro

    2007-01-01

    PCI Express is a new I/O technology for desktop, mobile, server and communications platforms designed to allow increasing levels of computer system performance. The serial nature of its links and the packet based protocols allows an easy geographical decoupling of a peripheral device. We have investigated the possibility of using an optical physical layer for the PCI Express, and we have built a bus adapter which can bridge remote busses (> 100m) to a single host computer without even the need of a specialized driver, given the legacy PCI compatibility of the PCI Express hardware. This adapter has been made tolerant to harsh environmental conditions, like strong magnetic fields or radiation fluxes, as the data acquisition needs of high energy physics experiments often require.

  19. Predictors of subjective health status 10 years post-PCI

    NARCIS (Netherlands)

    van den Berge, Jan C.; Dulfer, Karolijn; Utens, Elisabeth M. W. J.; Hartman, Eline M. J.; Daemen, Joost; van Geuns, Robert J.; van Domburg, Ron T.

    2016-01-01

    Subjective health status is an increasingly important parameter to assess the effect of percutaneous coronary intervention (PCI) in clinical practice. Aim of this study was to determine medical and psychosocial predictors of poor subjective health status over a 10 years' post-PCI period. We included

  20. Il PCI, Autonomia Operaia e l'emergenza terrorismo: il caso 7 aprile 1979

    Directory of Open Access Journals (Sweden)

    Giulia Pacifici

    2017-03-01

    Full Text Available The article analyzes the positions of the Italian Communist Party towards the large political movement that took action on its left, especially “Autonomia Operaia”, in the late seventies, during the terrorism emergency and the crisis of national solidarity governments. The debate, internal to the PCI and between the left parliamentary forces, is analyzed through the documents, the newspaper articles and the declarations about a specific counter-terrorism trial, known as the “7th April case". This trial caused a large and heated public debate on terrorism, democracy and public order that saw two main political positions in opposition to one another. On one side the so called guarantee position represented by the “Partito Radicale”, some intellectuals, journalist and magistrates and on the other those who endorsed the firmness position, especially the PCI. At the same time, within the same communist party, the firmness front wasn't completely unanimous. On 7th April 1979 the deputy public prosecutor of Padua, Pietro Calogero, issued an arrest warrant that led to prison more than a dozen militants from the extra-parliamentary leftist area, “Potere Operaio” and “Autonomia Operaia”, including among others Oreste Scalzone, Franco Piperno, Nanni Balestrini, Emilio Vesce and Antonio Negri.

  1. Bivalirudin Started during Emergency Transport for Primary PCI

    DEFF Research Database (Denmark)

    Steg, Philippe Gabriel; van 't Hof, Arnoud; Hamm, Christian W

    2013-01-01

    Bivalirudin, as compared with heparin and glycoprotein IIb/IIIa inhibitors, has been shown to reduce rates of bleeding and death in patients undergoing primary percutaneous coronary intervention (PCI). Whether these benefits persist in contemporary practice characterized by prehospital initiation...... of treatment, optional use of glycoprotein IIb/IIIa inhibitors and novel P2Y12 inhibitors, and radial-artery PCI access use is unknown....

  2. Assessments of whole body scan images (PCI) obtained in patients undergoing treatment of radioiodine (pre and post-treatment); Avaliacoes das imagens de pesquisa de corpo inteiro (PCI) obtidas em pacientes submetidos ao tratamento de radioiodoterapia (pre e pos-tratamento)

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Fernanda Karolina Mendonca da; Lopes Filho, Ferdinand de Jesus; Vieira, Jose Wilson; Souza, Milena Thays Barbosa de, E-mail: fernanda.radiologia8@gmail.com, E-mail: milena_thays@hotmail.com, E-mail: jose.wilson59@uol.com.br, E-mail: ferdinand.lopes@oi.com.br [Instituto Federal de Educacao, Ciencia e Tecnologia de Pernambuco (IFPE), Recife, PE (Brazil)

    2014-07-01

    Nuclear medicine is a medical specialty used for diagnosis and therapy of some diseases. For the treatment of differentiated thyroid carcinoma (papillary and follicular) Radioiodine therapy is employed, in order to eliminate the rest of thyroid tissue after removal of the thyroid (thyroidectomy). In radioiodine therapy is used radioisotope iodine-131 ({sup 131}I) as Sodium Iodide (NaI). The amount of the activity (dose) of {sup 131}I administered is generally the responsibility of nuclear medicine, which is based on an image Research Length of the patient (pre-dose therapy PCI). PCI is also used after treatment (post-PCI therapeutic dose) to evaluate possible metastasis. The purpose of this study was to investigate the distribution of biokinetic {sup 131}I at length and in some organs of the patient, in order to note any similarity. Exams PCI pre-dose and post-dose were analyzed, the anterior and posterior projections of ten patients. Contours in these images (ROI - Region Of Interest) were made in the whole body and in areas with high uptake of {sup 131}I. The total score was used in the calculation to obtain the percentage distribution of {sup 13I} in the organs of the patient. The results showed that there similarity on the biodistribution of {sup 131}I between pre-dose and post-dose PCI. Therefore, it was found that it is valuable images of PCI pre-dose therapy as a way to assist the nuclear medicine physician in choosing the best activity to be administered to the patient in order to minimize the dose to adjacent organs. (author)

  3. Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI.

    Science.gov (United States)

    Giustino, Gennaro; Chieffo, Alaide; Palmerini, Tullio; Valgimigli, Marco; Feres, Fausto; Abizaid, Alexandre; Costa, Ricardo A; Hong, Myeong-Ki; Kim, Byeong-Keuk; Jang, Yangsoo; Kim, Hyo-Soo; Park, Kyung Woo; Gilard, Martine; Morice, Marie-Claude; Sawaya, Fadi; Sardella, Gennaro; Genereux, Philippe; Redfors, Bjorn; Leon, Martin B; Bhatt, Deepak L; Stone, Gregg W; Colombo, Antonio

    2016-10-25

    Optimal upfront dual antiplatelet therapy (DAPT) duration after complex percutaneous coronary intervention (PCI) with drug-eluting stents (DES) remains unclear. This study investigated the efficacy and safety of long-term (≥12 months) versus short-term (3 or 6 months) DAPT with aspirin and clopidogrel according to PCI complexity. The authors pooled patient-level data from 6 randomized controlled trials investigating DAPT durations after PCI. Complex PCI was defined as having at least 1 of the following features: 3 vessels treated, ≥3 stents implanted, ≥3 lesions treated, bifurcation with 2 stents implanted, total stent length >60 mm, or chronic total occlusion. The primary efficacy endpoint was major adverse cardiac events (MACE), defined as the composite of cardiac death, myocardial infarction, or stent thrombosis. The primary safety endpoint was major bleeding. Intention-to-treat was the primary analytic approach. Of 9,577 patients included in the pooled dataset for whom procedural variables were available, 1,680 (17.5%) underwent complex PCI. Overall, 85% of patients received new-generation DES. At a median follow-up time of 392 days (interquartile range: 366 to 710 days), patients who underwent complex PCI had a higher risk of MACE (adjusted hazard ratio [HR]: 1.98; 95% confidence interval [CI]: 1.50 to 2.60; p PCI group (adjusted HR: 0.56; 95% CI: 0.35 to 0.89) versus the noncomplex PCI group (adjusted HR: 1.01; 95% CI: 0.75 to 1.35; p interaction  = 0.01). The magnitude of the benefit with long-term DAPT was progressively greater per increase in procedural complexity. Long-term DAPT was associated with increased risk for major bleeding, which was similar between groups (p interaction  = 0.96). Results were consistent by per-treatment landmark analysis. Alongside other established clinical risk factors, procedural complexity is an important parameter to take into account in tailoring upfront duration of DAPT. Copyright © 2016 American College

  4. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock.

    Science.gov (United States)

    Thiele, Holger; Akin, Ibrahim; Sandri, Marcus; Fuernau, Georg; de Waha, Suzanne; Meyer-Saraei, Roza; Nordbeck, Peter; Geisler, Tobias; Landmesser, Ulf; Skurk, Carsten; Fach, Andreas; Lapp, Harald; Piek, Jan J; Noc, Marko; Goslar, Tomaž; Felix, Stephan B; Maier, Lars S; Stepinska, Janina; Oldroyd, Keith; Serpytis, Pranas; Montalescot, Gilles; Barthelemy, Olivier; Huber, Kurt; Windecker, Stephan; Savonitto, Stefano; Torremante, Patrizia; Vrints, Christiaan; Schneider, Steffen; Desch, Steffen; Zeymer, Uwe

    2017-12-21

    In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock have multivessel disease, and whether PCI should be performed immediately for stenoses in nonculprit arteries is controversial. In this multicenter trial, we randomly assigned 706 patients who had multivessel disease, acute myocardial infarction, and cardiogenic shock to one of two initial revascularization strategies: either PCI of the culprit lesion only, with the option of staged revascularization of nonculprit lesions, or immediate multivessel PCI. The primary end point was a composite of death or severe renal failure leading to renal-replacement therapy within 30 days after randomization. Safety end points included bleeding and stroke. At 30 days, the composite primary end point of death or renal-replacement therapy had occurred in 158 of the 344 patients (45.9%) in the culprit-lesion-only PCI group and in 189 of the 341 patients (55.4%) in the multivessel PCI group (relative risk, 0.83; 95% confidence interval [CI], 0.71 to 0.96; P=0.01). The relative risk of death in the culprit-lesion-only PCI group as compared with the multivessel PCI group was 0.84 (95% CI, 0.72 to 0.98; P=0.03), and the relative risk of renal-replacement therapy was 0.71 (95% CI, 0.49 to 1.03; P=0.07). The time to hemodynamic stabilization, the risk of catecholamine therapy and the duration of such therapy, the levels of troponin T and creatine kinase, and the rates of bleeding and stroke did not differ significantly between the two groups. Among patients who had multivessel coronary artery disease and acute myocardial infarction with cardiogenic shock, the 30-day risk of a composite of death or severe renal failure leading to renal-replacement therapy was lower among those who initially underwent PCI of the culprit lesion only than among those

  5. Comparison Between PCI and Box Girder in BridgesPrestressed Concrete Design

    Science.gov (United States)

    Rahmawati, Cut; Zainuddin, Z.; Is, Syafridal; Rahim, Robbi

    2018-04-01

    This research is done by comparing PCI and Box Girder types of prestressed concrete design. The method used is load balance. Previous studies have just discussed the differences in terms of effectiveness and economics. In this study, the researchers want to know the design process by comparing the working forces, the resulting moment, and the losses of the prestressed. As the case in this study, the researchers used the bridge with the span of 31 meters. The tendon pulling system was conducted with post-tensioning system The analysis result showed that prestressed of the Girder box type sustained the greatest moment due to the combination of its own weight, additional dead load, lane load, and wind load of 44,029 kNm, while the biggest moment of PCI Girder was 7,556.75 KNm The Girder beam box experiences greater moment and shear force than PCI Girder. This is the effect of the weight of its own Girderboxwaslarger than PCI Girder. The losses ofprestressed style of Girderboxand PCI Girder type were 24.85% and 26.32%, respectively.Moreover, it showed that the type of Girder box is cheaper, easier, and more efficient than PCI Girder.

  6. Simulation systems, models and calculations; Le strategie di ricerca. Sistemi di simulazione, modellistica e calcolo

    Energy Technology Data Exchange (ETDEWEB)

    Mathis, A.; Novelli, P. [ENEA, Rome (Italy)

    1998-07-01

    Historically, theory and experimentation have been used to conduct scientific research. Simulation is emerging as a powerful third approach, to discovery, introducing many new challengers and opportunities in solving complex scientific problems. [Italian] Le competenze, le tecnologie e le infrastrutture per il calcolo ad alte prestazioni costituiscono una strumentazione di valenza strategica per il conseguimento degli obiettivi posti da una gestione ottimale dell'energia e dell'ambiente nel nostro Paese. In tale ambito la scienza della Simulazione e' stata individuata come terza via parallela alla sperimenazione e alla teoria.

  7. PCI DSS a practical guide to implementing and maintaining compliance

    CERN Document Server

    Wright, Steve

    2011-01-01

    This newly revised, practical guide, gives you a step by step guide to achieving Payment Card Industry Data Security Standard (PCI DSS) compliance - showing you how to create, design and build a PCI compliance framework.

  8. I big data e gli strumenti di visualizzazione analitica: interazioni e studi induttivi per le P.A.

    Directory of Open Access Journals (Sweden)

    Giuseppe Roccasalva

    2012-12-01

    Full Text Available Il saggio presenta alcuni risultati di una collaborazione tra Politecnico di Torino e il CSI Piemonte (Società di servizi Informatizzati partecipata dalla Regione Piemonte. Sono stati selezionati e studiati diversi strumenti di visualizzazione dei dati scientifici (Gapminder, ManyEyes, Open eXplorer e Fineo al fine di individuare quello più utile per una lettura induttiva di grandi quantità di dati informativi (big data. Lo sfruttamento intelligente dei dati digitali può portare a uno sviluppo conoscitivo ma anche a un profitto, le cui soglie di sfruttamento possono essere misurate in un sistema economico. Nell’irreversibile fenomeno di crescita dei dati digitali, la disciplina del “Data Visualization” diventa cruciale per accedere e comprendere informazioni complesse. Few, guru della comunicazione visiva, scrive che “scopriamo il mondo attraverso gli occhi”; le forme di comunicazione e interpretazione tradizionali dei dati hanno puntato sulla dimensione visuale per migliorare la comprensione e hanno permesso sia agli analisti sia agli utenti la sperimentazione di nuove interazioni (“story-telling”. Come urbanisti e cittadini, ci affidiamo alla vista che gestisce molti dei sensori (70% legati alla percezione, alle mappe cognitive, agli errori e ai nuovi pensieri. L’ipotesi di fondo di questo articolo vuole generare delle riflessioni sui Big Data come strategia importante per le imprese pubbliche e private che intendono imparare a cambiare dalle informazioni digitali di cui oggi disponiamo. Attraverso l’uso di uno strumento analitico di visualizzazione dei dati informativi, si descrive un recente caso di studio in un contesto territoriale come quello dei nuovi consorzi amministrativi (Unione dei Comuni NordEst Torino. In questo esperimento torna a essere attuale la necessità di pianificare le scelte in modo sistematico anche cercando di utilizzare in modo nuovo e semplice i sistemi informativi territoriali già disponibili.

  9. Optimal catchment area and primary PCI centre volume revisited

    DEFF Research Database (Denmark)

    Schoos, Mikkel Malby; Pedersen, Frants; Holmvang, Lene

    2015-01-01

    AIMS: The currently stated optimal catchment population for a pPCI centre is 300,000-1,100,000, resulting in 200-800 procedures/year. pPCI centres are increasing in number even within small geographic areas. We describe the organisation and quality of care after merging two high-volume centres...

  10. LA LINGUA ITALIANA E LE SCUOLE ITALIANE NEL TERRITORIO ISTRIANO

    Directory of Open Access Journals (Sweden)

    Chiara De Battisti

    2011-02-01

    Full Text Available L’articolo ricostruisce brevemente, dal punto di vista storico, le vicende della comunità italiana in Istria per contestualizzarne i mutamenti di carattere linguistico e socioculturale che essa ha vissuto, in particolare dal secondo dopoguerra ad oggi. Sulla base di studi e indagini  recenti, vengono prese in esame le lingue e i dialetti parlati dalla comunità italiana, la realtà multilingue e multiculturale dell’Istria attuale,  le istituzioni italiane presenti nel territorio istriano e la loro attività finalizzata alla permanenza della lingua e cultura italiana nella regione. In particolare si ricostruisce la storia della scuola di lingua italiana, le sue origini, il suo declino dopo la cessione dell’Istria alla Yugolaslavia e durante i difficili e drammatici anni dell’esodo di molti italiano dalla regione, la sua rinascita ed evoluzione dal 1980 ad oggi. Delle scuole di lingua italiana, che attualmente operano sia nel territorio istriano che fa parte della Slovenia sia in quello che fa parte della Croazia, si analizza la loro distribuzione nella regione, la loro organizzazione, il ruolo della lingua italiana come materia, come lingua di scolarizzazione e come lingua straniera, i problemi, ancora aperti, della formazione degli insegnanti e dei libri di testo, e si valuta la loro possibilità di evoluzione e di sviluppo.     Italian language and Italian schools in the territory if Istria   This article briefly discusses, from the historical point of view, the Italian community in Istria to contextualize the linguistic and socio cultural changes that have taken place in the region, especially after WWII. Based on recent surveys and studies, languages and dialects spoken in the Italian community, the multilungual and multicultural reality of Istria are examined, as well as the Italian institutions in the Istrian territory and their efforts to conserve Italian language and culture in the area.  In particular, the history of

  11. LOS PIROPOS EN EL AULA DE E/LE

    Directory of Open Access Journals (Sweden)

    Virginia Vázquez Hernández

    2011-10-01

    Full Text Available En este trabajo presentamos cuatro propuestas didácticas y diversos materiales con los que trabajar el piropo en la clase de español como lengua extranjera, contenido poco trabajado según el análisis realizado en una serie de manuales de E/LE. Asimismo, presentamos unas reflexiones sobre la naturaleza del piropo (frente al cumplido y sobre los beneficios que obtendremos con la presentación de dicho contenido en las clases de E/LE.In this work we aimed to make four didactic proposals and materials that might be helpful in order to study the compliments in the Spanish as a Second Language (SSL class. Flaterous comments and compliments are generally underestimated in language teaching, as we could observe from the analysis of a series of SSL workbooks. Therefore, we present several ideas on the nature of these expressions and on the benefitsof their presentation in the class.

  12. Le donne e lo sport dal dopoguerra a oggi

    Directory of Open Access Journals (Sweden)

    Eugenia Porro

    2013-04-01

    Full Text Available La pratica sportiva femminile nell'Italia postbellica appare per alcuni versi un oggetto misterioso, collocandosi all'interno di quelli che fino a qualche anno fa venivano considerati due sotto-universi della sociologia: la sociologia dello sport e la sociologia di genere. È dunque importante analizzare l'evoluzione della pratica sportiva al femminile tenendo conto di variabili diverse sul piano socio-culturale e facendo altresì riferimento al patrimonio statistico di cui si dispone. In questo senso, per una più corretta analisi del fenomeno, si è scelto di differenziare il sistema della prestazione assoluta da quello della prestazione relativa. In tal modo, vengono poste in luce le dinamiche che interessano le politiche di genere, come la rivendicazione di diritti o di riforme sociali che diano impulso alla diffusione della pratica femminile. Insieme, si concentra l’analisi su fenomeni particolarmente rilevanti per il settore sportivo in generale quali la mediatizzazione e la politicizzazione.

  13. 47 CFR 61.45 - Adjustments to the PCI for Local Exchange Carriers.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Adjustments to the PCI for Local Exchange... CARRIER SERVICES (CONTINUED) TARIFFS General Rules for Dominant Carriers § 61.45 Adjustments to the PCI... adjustments to the PCI for each basket as part of the annual price cap tariff filing, and shall maintain...

  14. Comparative Effectiveness of PCI Education's "PCI Reading Program": Phase 2--A Report of a Comparison Group Study in Brevard Public Schools and Miami-Dade County Public Schools. Research Summary

    Science.gov (United States)

    Empirical Education Inc., 2010

    2010-01-01

    PCI Education sought scientifically based evidence on the comparative effectiveness of the "PCI Reading Program" through a five-year longitudinal study. Phase 1 of the study consisted of a randomized control trial studying the efficacy of the "PCI Reading Program-Level One" that was conducted in the 2007-2008 in Miami-Dade…

  15. L'evoluzione della stampa 3D e le sue applicazioni in campo museale

    OpenAIRE

    Pignatelli, Francesco

    2014-01-01

    ItLa stampa 3D è passata dall'uso solo industriale al grande pubblico degli appassionati e dei maker. Questa evoluzione interessa anche i musei, che possono adottare le tecniche di stampa 3D per rendere più fruibili le loro collezioni, creare una maggiore interattività con il pubblico potenziale e generare nuovo business attraverso il merchandising. Più in futuro i musei andranno verso un modello in cui l'originale e la copia ad alta precisione ottenuta con la stampa 3D, e persino il suo mode...

  16. Independent predictors of retrograde failure in CTO-PCI after successful collateral channel crossing.

    Science.gov (United States)

    Suzuki, Yoriyasu; Muto, Makoto; Yamane, Masahisa; Muramatsu, Toshiya; Okamura, Atsunori; Igarashi, Yasumi; Fujita, Tsutomu; Nakamura, Shigeru; Oida, Akitsugu; Tsuchikane, Etsuo

    2017-07-01

    To evaluate factors for predicting retrograde CTO-PCI failure after successful collateral channel crossing. Successful guidewire/catheter collateral channel crossing is important for the retrograde approach in percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). A total of 5984 CTO-PCI procedures performed in 45 centers in Japan from 2009 to 2012 were studied. The retrograde approach was used in 1656 CTO-PCIs (27.7%). We investigated these retrograde procedures to evaluate factors for predicting retrograde CTO-PCI failure even after successful collateral channel crossing. Successful guidewire/catheter collateral crossing was achieved in 77.1% (n = 1,276) of 1656 retrograde CTO-PCI procedures. Retrograde procedural success after successful collateral crossing was achieved in 89.4% (n = 1,141). Univariate analysis showed that the predictors for retrograde CTO-PCI failure were in-stent occlusion (OR = 1.9829, 95%CI = 1.1783 - 3.3370 P = 0.0088), calcified lesions (OR = 1.9233, 95%CI = 1.2463 - 2.9679, P = 0.0027), and lesion tortuosity (OR = 1.5244, 95%CI = 1.0618 - 2.1883, P = 0.0216). On multivariate analysis, lesion calcification was an independent predictor of retrograde CTO-PCI failure after successful collateral channel crossing (OR = 1.3472, 95%CI = 1.0614 - 1.7169, P = 0.0141). The success rate of retrograde CTO-PCI following successful guidewire/catheter collateral channel crossing was high in this registry. Lesion calcification was an independent predictor of retrograde CTO-PCI failure after successful collateral channel crossing. Devices and techniques to overcome complex CTO lesion morphology, such as lesion calcification, are required to further improve the retrograde CTO-PCI success rate. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  17. Lack of consensus in biomarker measurement to diagnose PCI-related myocardial infarction

    DEFF Research Database (Denmark)

    Al-Dakhiel, Zaid; Rune Larsen, Søren; Svenstrup Poulsen, Tina

    2008-01-01

    Objective. To evaluate if biomarker sampling in PCI has adhered to the 2 000 consensus document for the diagnosis of procedure-related myocardial infarction (MI). Design. Firstly, a review of relevant papers from 2000 to September 2007 was done. Secondly, in October 2007, a questionnaire addressing...... biomarker sampling in routine PCI was sent to Danish PCI centres. Results. Fourteen papers fulfilled the selection criteria. In six studies serial sampling according to the consensus document had been done. Biomarker measuring before PCI was not performed in four studies. All centres answered...... the questionnaire. In none of six centres the proposed 3-sample testing of biomarkers had been followed. A pre-PCI sample was taken in one centre. In approximately half of the centres biomarkers were only measured on clinical indication. Conclusion. Biomarker sampling for procedure-related MI according to the 2 000...

  18. Coplanar (e, 3e) differential cross-section of He atom

    CERN Document Server

    Choubisa, R; Sud, K K

    2003-01-01

    We present in this paper the results of our calculation of five-fold differential cross-section (FDCS) for (e, 3e) process on He atom in low momentum transfer and high electron impact energy in shake-off mechanism. The formalism has been developed in Born approximation using plane waves. Byron and Joachain as well as Le Sech and correlated BBK-type wave functions respectively for incident and scattered. bound and ejected electrons. The angular distribution of FDCS of our calculation is presented in various modes of coplanar geometry and comparison is made with the available experimental data. We observe that the present calculation is able to reproduce the trend of the experimental data. However, it differs in magnitude from the experiment. The present theory does not predict four-peak structure in summed mutual angle mode for lower excess ejected electron energies. We also discuss the importance of momentum transfer, post-collision interaction (PCI) and ion participation in the (e, 3e) process in constant th...

  19. Le Terme a sud del Pretorio di Gortina. Produzione e circolazione dei contenitori da trasporto

    Directory of Open Access Journals (Sweden)

    Ilaria De Aloe

    2010-03-01

    Full Text Available La posizione centrale nell’Egeo ed i pochi giorni di navigazione dall’Africa e dall’Egitto, come dalla Siria e Palestina, hanno reso la città di Gortina, e Creta stessa, un punto nevralgico all’interno delle rotte commerciali di collegamento e distribuzione di beni tra le sponde del Mediterraneo. Lo studio delle anfore rinvenute nelle campagne di scavo 2003-2006 presso le Terme a sud del Pretorio, ed il necessario confronto con le grandi quantità di materiali provenienti soprattutto dai contesti del Pretorio confermano questa intricata rete commerciale. Già tra Ellenismo e prima età imperiale romana, Gortina svolse una funzione di mercato di raccolta e probabilmente di smistamento delle merci provenienti dall’Occidente e dall’Egeo, assumendo poi nella piena età imperiale, un ruolo sempre più attivo nella produzione delle stesse. La mutata situazione socio-economica dell’età tardo romana - bizantina, nonché la fondazione di una nuova capitale, Costantinopoli, portò Creta e Gortina ad avere scambi commerciali e collegamenti intensi soprattutto con le aree orientali del Mediterraneo privilegiando l’importazione di prodotti dall’esterno.

  20. PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway.

    Science.gov (United States)

    Zhang, Wei; Lv, Shengqing; Liu, Jun; Zang, Zhenle; Yin, Junyi; An, Ning; Yang, Hui; Song, Yechun

    2014-10-01

    PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrations of PCI-24781 (0, 0.25, 0.5, 1, 2.5 and 5 μM) and analyzed for cell proliferation by the MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay and colony formation, and cell cycle and apoptosis were assessed by flow cytometry. The expression of EZH2 and apoptosis-related proteins was assessed by western blotting. Malignant glioma cells were also transfected with EZH2 siRNA to examine how PCI-24781 suppresses tumor cells. EZH2 was highly expressed in the three glioma cell lines. Incubation with PCI-24781 reduced cell proliferation and increased cell apoptosis by down-regulating EZH2 in a concentration-dependent manner. These effects were simulated by EZH2 siRNA. In addition, PCI-24781 or EZH2 siRNA accelerated cell apoptosis by down-regulating the expression of AKT, mTOR, p70 ribosomal protein S6 kinase (p70s6k), glycogen synthase kinase 3A and B (GSK3a/b) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1). These data suggest that PCI-24781 may be a promising therapeutic agent for treating gliomas by down-regulating EZH2 which promotes cell apoptosis by suppressing the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of the rapamycin (mTOR) pathway.

  1. [EARLY RATHER THAN IMMEDIATE PCI IN NSTEMI; IS TIME EQUAL TO MUSCLE ONCE AGAIN?

    Science.gov (United States)

    Carasso, Shemy; Nassar, Ali; Kuzniec, Fabio; Hazanov, Yevgeni; Salman, Nabeeh; Halhla, Yussra; Amir, Offer; Ghanem, Diab

    2017-10-01

    Current guidelines advocate immediate vs. non-immediate percutaneous coronary intervention (PCI) strategy in ST elevation vs. non ST elevation myocardial infarction (STEMI, NSTEMI). There is however increasing concern that "next-day PCI" in NSTEMI may adversely affect LV systolic and/or diastolic function and a more urgent aggressive approach should be taken in NSTEMI, similar to that in STEMI. In the current study we compared echocardiographic data between patients with STEMI and NSTEMI who had either primary or early PCI respectively. Prospective data of 165 consecutive patients with an acute MI were analyzed. Patients had primary PCI if they had STEMI and non-emergent PCI if they had NSTEMI. Demographic information, laboratory test results, procedure time and post-PCI echocardiographic assessment were compared between the two groups. Patients with STEMI were younger compared to patients with NSTEMI. Time to intervention was significantly longer in NSTEMI, reflecting guideline derived intervention strategy (1.9±1.7days, (median 1day) vs. 30±15min, for NSTEMI and STEMI, respectively, pPCI up to 72 hours in patients with NSTEMI did not adversely affect left ventricular systolic and/or diastolic function compared to immediate PCI in patients with STEMI. Based on current data, we conclude that early PCI intervention rather than an immediate one is appropriate in NSTEMI patients.

  2. Higher plasma level of STIM1, OPG are correlated with stent restenosis after PCI.

    Science.gov (United States)

    Li, Haibin; Jiang, Zhian; Liu, Xiangdong; Yang, Zhihui

    2015-01-01

    Percutaneous Coronary Intervention (PCI) is one of the most effective treatments for Coronary Heart Disease (CHD), but the high rate of In Stent Restenosis (ISR) has plagued clinicians after PCI. We aim to investigate the correlation of plasma Stromal Interaction Molecular 1 (STIM1) and Osteoprotegerin (OPG) level with stent restenosis after PCI. A total of 100 consecutive patients with Coronary Heart Disease (CHD) received PCI procedure were recruited. Coronary angiography was performed 8 months after their PCI. Then patients were divided into 2 groups: observation group was composed by patients who existing postoperative stenosis after intervention; Control group was composed by patients with no postoperative stenosis. The plasma levels of STIM, OPG in all patients were tested before and after intervention. Pearson correlation and multiple linear regression analysis were performed to analysis the correlation between STIM, OPG level and postoperative stenosis. 35 cases were divided into observation group and other 65 were divided into control group. The plasma levels of STIM, OPG have no statistical difference before their PCI procedure, but we observed higher level of High-sensitivity C-reactive protein (Hs-CRP) existed in observation group. We observed higher level of plasma STIM, OPG in observation group when compared with control group after PCI procedure (P PCI, which could provide useful information for the restenosis control after PCI.

  3. Rapport sur le développement dans le monde sur le thème du rôle ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... rural et sont tributaires principalement de l'agriculture pour assurer leur subsistance. Ce projet permettra de veiller à ce qu'une place soit accordée aux travaux de recherche financés par le CRDI, aux points de vue différents et aux auteurs de l'hémisphère Sud dans le Rapport sur le développement dans le monde 2008.

  4. Single-Staged Compared With Multi-Staged PCI in Multivessel NSTEMI Patients: The SMILE Trial.

    Science.gov (United States)

    Sardella, Gennaro; Lucisano, Luigi; Garbo, Roberto; Pennacchi, Mauro; Cavallo, Erika; Stio, Rocco Edoardo; Calcagno, Simone; Ugo, Fabrizio; Boccuzzi, Giacomo; Fedele, Francesco; Mancone, Massimo

    2016-01-26

    A lack of clarity exists about the role of complete coronary revascularization in patients presenting with non-ST-segment elevation myocardial infarction. The aim of our study was to compare long-term outcomes in terms of major adverse cardiovascular and cerebrovascular events of 2 different complete coronary revascularization strategies in patients with non-ST-segment elevation myocardial infarction and multivessel coronary artery disease: 1-stage percutaneous coronary intervention (1S-PCI) during the index procedure versus multistage percutaneous coronary intervention (MS-PCI) complete coronary revascularization during the index hospitalization. In the SMILE (Impact of Different Treatment in Multivessel Non ST Elevation Myocardial Infarction Patients: One Stage Versus Multistaged Percutaneous Coronary Intervention) trial, 584 patients were randomly assigned in a 1:1 manner to 1S-PCI or MS-PCI. The primary study endpoint was the incidence of major adverse cardiovascular and cerebrovascular events, which were defined as cardiac death, death, reinfarction, rehospitalization for unstable angina, repeat coronary revascularization (target vessel revascularization), and stroke at 1 year. The occurrence of the primary endpoint was significantly lower in the 1-stage group (1S-PCI: n = 36 [13.63%] vs. MS-PCI: n = 61 [23.19%]; hazard ratio [HR]: 0.549 [95% confidence interval (CI): 0.363 to 0.828]; p = 0.004). The 1-year rate of target vessel revascularization was significantly higher in the MS-PCI group (1S-PCI: n = 22 [8.33%] vs. MS-PCI: n = 40 [15.20%]; HR: 0.522 [95% CI: 0.310 to 0.878]; p = 0.01; p log-rank = 0.013). When the analyses were limited to cardiac death (1S-PCI: n = 9 [3.41%] vs. MS-PCI: n = 14 [5.32%]; HR: 0.624 [95% CI: 0.270 to 1.441]; p = 0.27) and myocardial infarction (1S-PCI: n = 7 [2.65%] vs. MS-PCI: n = 10 [3.80%]; HR: 0.678 [95% CI: 0.156 to 2.657]; p = 0.46), no significant differences were observed between groups. In multivessel

  5. Factors Associated With Ineligibility for PCI Differ Between Inpatient and Outpatient ST-Elevation Myocardial Infarction.

    Science.gov (United States)

    Jaski, Brian E; Grigoriadis, Christopher E; Dai, Xuming; Meredith, Richard D; Ortiz, Bryan C; Stouffer, George A; Thomas, Lorie; Smith, Sidney C

    2016-08-01

    Without early revascularization, both inpatient and outpatient STEMIs have poor outcomes. Reasons for denying PCI for STEMI, however, remain uncertain. This single-center retrospective cohort study compares factors and outcomes associated with ineligibility for PCI between inpatients and outpatients following ST-elevation myocardial infarction (STEMI). A total of 1,759 STEMI patients between June 2009 and January 2015 were assessed. Individual medical records were reviewed to obtain reasons for PCI ineligibility for STEMI patients who did not receive reperfusion therapy. Compared to outpatients with STEMI (n = 1,688), inpatients (n = 71) were less likely to receive coronary angiography (60.6% vs 95.9%; P PCI (50.7% vs 80.9%; P PCI and procedural success were seen in both groups. Principal contraindication for PCI was risk of bleeding within the inpatient population and complex coronary artery disease within the outpatient population. Total in-hospital mortality was higher in inpatient STEMIs compared to outpatients (42.2% vs 10.0%; P PCI in both groups. Reasons for PCI ineligibility differ between inpatient and outpatient STEMIs. Inpatients have increased risks of bleeding, lower coronary angiography and PCI use, and higher in-hospital mortality. Especially for inpatients, specific PCI STEMI protocols that anticipate and overcome types of ineligibility and delay for cardiac catheterization may improve outcomes. © 2016, Wiley Periodicals, Inc.

  6. A registry-based randomized trial comparing radial and femoral approaches in women undergoing percutaneous coronary intervention: the SAFE-PCI for Women (Study of Access Site for Enhancement of PCI for Women) trial.

    Science.gov (United States)

    Rao, Sunil V; Hess, Connie N; Barham, Britt; Aberle, Laura H; Anstrom, Kevin J; Patel, Tejan B; Jorgensen, Jesse P; Mazzaferri, Ernest L; Jolly, Sanjit S; Jacobs, Alice; Newby, L Kristin; Gibson, C Michael; Kong, David F; Mehran, Roxana; Waksman, Ron; Gilchrist, Ian C; McCourt, Brian J; Messenger, John C; Peterson, Eric D; Harrington, Robert A; Krucoff, Mitchell W

    2014-08-01

    This study sought to determine the effect of radial access on outcomes in women undergoing percutaneous coronary intervention (PCI) using a registry-based randomized trial. Women are at increased risk of bleeding and vascular complications after PCI. The role of radial access in women is unclear. Women undergoing cardiac catheterization or PCI were randomized to radial or femoral arterial access. Data from the CathPCI Registry and trial-specific data were merged into a final study database. The primary efficacy endpoint was Bleeding Academic Research Consortium type 2, 3, or 5 bleeding or vascular complications requiring intervention. The primary feasibility endpoint was access site crossover. The primary analysis cohort was the subgroup undergoing PCI; sensitivity analyses were conducted in the total randomized population. The trial was stopped early for a lower than expected event rate. A total of 1,787 women (691 undergoing PCI) were randomized at 60 sites. There was no significant difference in the primary efficacy endpoint between radial or femoral access among women undergoing PCI (radial 1.2% vs. 2.9% femoral, odds ratio [OR]: 0.39; 95% confidence interval [CI]: 0.12 to 1.27); among women undergoing cardiac catheterization or PCI, radial access significantly reduced bleeding and vascular complications (0.6% vs. 1.7%; OR: 0.32; 95% CI: 0.12 to 0.90). Access site crossover was significantly higher among women assigned to radial access (PCI cohort: 6.1% vs. 1.7%; OR: 3.65; 95% CI: 1.45 to 9.17); total randomized cohort: (6.7% vs. 1.9%; OR: 3.70; 95% CI: 2.14 to 6.40). More women preferred radial access. In this pragmatic trial, which was terminated early, the radial approach did not significantly reduce bleeding or vascular complications in women undergoing PCI. Access site crossover occurred more often in women assigned to radial access. (SAFE-PCI for Women; NCT01406236). Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc

  7. Konrad Mäe medal Laurentsiusele ja A. D.-le

    Index Scriptorium Estoniae

    1999-01-01

    Konrad Mäe medal ja preemia 1999. a. loomingu eest anti 19. XI Rüütelkonna hoones üle maalikunstnik Lauri Sillakule (Laurentsius) ja Anna Daniela Saalistele (A. D.) Tallinna Linnagaleriis toimunud näitusel eksponeeritud suureformaadiliste maalikompositsioonide 'The End', 'Aadam' ja 'Eeva' eest

  8. Effect of platelet inhibition with cangrelor during PCI on ischemic events

    NARCIS (Netherlands)

    Bhatt, D.L.; Stone, G.W.; Mahaffey, K.W.; Gibson, C.M.; Steg, P.G.; Hamm, C.W.; Price, M.J.; Leonardi, S.; Gallup, D.; Bramucci, E.; Radke, P.W.; Widimsky, P.; Tousek, F.; Tauth, J.; Spriggs, D.; McLaurin, B.T.; Angiolillo, D.J.; Genereux, P.; Liu, T.; Prats, J.; Todd, M.; Skerjanec, S.; White, H.D.; Harrington, R.A.; Verheugt, F.W.; et al.,

    2013-01-01

    BACKGROUND: The intensity of antiplatelet therapy during percutaneous coronary intervention (PCI) is an important determinant of PCI-related ischemic complications. Cangrelor is a potent intravenous adenosine diphosphate (ADP)-receptor antagonist that acts rapidly and has quickly reversible effects.

  9. Thrombolysis in the age of Primary Percutaneous Coronary Intervention: Mini-Review and Meta-analysis of Early PCI.

    Science.gov (United States)

    Al Shammeri, O; Garcia, LA

    2013-01-01

    Primary Percutaneous Coronary Intervention (PCI) is the treatment of choice for ST-segment Elevation Myocardial Infarction (STEMI) if performed within 90 minutes from first medical contact. However, primary PCI is only available for less than 25% of patients with STEMI. Early PCI or Pharmaco-invasive strategy has evolved from facilitated PCI but with more delayed timing from thrombolysis to PCI. Assess the safety and effectiveness of Early PCI. We reviewed the data of the available therapy options for patients with STEMI. Then we performed a meta-analysis for all randomized controlled trials of early PCI versus standard therapy. Five studies fulfilled our inclusion criteria. Our meta-analysis showed improved cardiovascular events with early PCI compared to standard therapy (odd ratio of 0.54; 95% Confidence interval 0.47-0.7, pearly PCI 4 to 24 hours after successful thrombolysis. Early PCI should be done to all STEMI patients within 24 hours after successful thrombolysis.

  10. Thrombolysis in the age of Primary Percutaneous Coronary Intervention: Mini-Review and Meta-analysis of Early PCI

    Science.gov (United States)

    Al Shammeri, O; Garcia, LA

    2013-01-01

    Objective Primary Percutaneous Coronary Intervention (PCI) is the treatment of choice for ST-segment Elevation Myocardial Infarction (STEMI) if performed within 90 minutes from first medical contact. However, primary PCI is only available for less than 25% of patients with STEMI. Early PCI or Pharmaco-invasive strategy has evolved from facilitated PCI but with more delayed timing from thrombolysis to PCI. Aim Assess the safety and effectiveness of Early PCI. Patients and Method We reviewed the data of the available therapy options for patients with STEMI. Then we performed a meta-analysis for all randomized controlled trials of early PCI versus standard therapy Results Five studies fulfilled our inclusion criteria. Our meta-analysis showed improved cardiovascular events with early PCI compared to standard therapy (odd ratio of 0.54; 95% Confidence interval 0.47-0.7, pPCI 4 to 24 hours after successful thrombolysis Conclusion Early PCI should be done to all STEMI patients within 24 hours after successful thrombolysis. PMID:23559909

  11. A new PCI card for readout in high energy physics experiments

    CERN Document Server

    Floris, M; Marras, D; Usai, G L; David, A

    2004-01-01

    Recently some high energy physics experiments started to adopt readout systems based on the PCI architecture. In this context a new PCI card that can be adapted to several readout schemes has been designed. The card contains a large 64 MB local buffer, programmable FPGA logic and a PLX PCI bridge. The solution to use a PCI bridge external to the programmable logic allows to greatly simplify projects at the level of the on-board local bus. The card is presently used as the basic readout unit of the NA60 experiment. In this context, coupling it to different mezzanine cards it is possible to create interfaces to VME/CAMAC modules or to custom front-end electronics as for the case of the silicon vertex detector. Moreover, it is used as a readout test system for the ALICE muon chambers. (10 refs).

  12. Absence of mutations in the PCI gene in subfertile men

    NARCIS (Netherlands)

    Gianotten, Judith; Schimmel, Alinda W. M.; van der Veen, Fulco; Lombardi, M. Paola; Meijers, Joost C. M.

    2004-01-01

    The molecular aetiology of male subfertility is still unknown in the majority of cases and it is thought that multiple genes are involved. One of the genes that might play a role in male reproductive function is the protein C inhibitor (PCI) gene. In mice the presence of PCI is an absolute

  13. When high-volume PCI operators in high-volume hospitals move to lower volume hospitals-Do they still maintain high volume and quality of outcomes?

    Science.gov (United States)

    Lu, Tsung-Hsueh; Li, Sheng-Tun; Liang, Fu-Wen; Lee, Jo-Chi; Yin, Wei-Hsian

    2017-10-31

    The aim of this quasi-experimental study was to examine whether high-volume percutaneous coronary intervention (PCI) operators still maintain high volume and quality of outcomes when they moved to lower volume hospitals. Systematic reviews have indicated that high-volume PCI operators and hospitals have higher quality outcomes. However, little is known on whether high PCI volume and high quality outcomes are mainly due to operator characteristics (i.e., skill and experience) and is portable across organizations or whether it is due to hospital characteristics (i.e., equipment, team, and management system) and is less portable. We used Taiwan National Health Insurance claims data 2000-2012 to identify 98 high-volume PCI operators, 10 of whom moved from one hospital to another during the study period. We compared the PCI volume, risk-adjusted mortality ratio, and major adverse cardiovascular event (MACE) ratio before and after moving. Of the 10 high-volume operators who moved, 6 moved from high- to moderate- or low-volume hospitals, with median annual PCI volumes (interquartile range) of 130 (117-165) in prior hospitals and 54 (46-84) in subsequent hospitals (the hospital the operator moved to), and the remaining 4 moved from high to high-volume hospitals, with median annual PCI volumes (interquartile range) of 151 (133-162) in prior hospitals and 193 (178-239) in subsequent hospitals. No significant differences were observed in the risk-adjusted mortality ratios and MACE ratios between high-volume operators and matched controls before and after moving. High-volume operators cannot maintain high volume when they moved from high to moderate or low-volume hospitals; however, the quality of care is maintained. High PCI volume and high-quality outcomes are less portable and more hospital bound. © 2017 Wiley Periodicals, Inc.

  14. Discrimination fondée sur l'appartenance ethnique et le sexe dans ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet a pour objectif de permettre de mieux comprendre les types de discrimination fondée sur le sexe, la classe et l'appartenance ethnique auxquels les femmes autochtones sont confrontées. Trois équipes de femmes autochtones ont été formées en Argentine, en Colombie et au Mexique et ont choisi le thème qui ...

  15. Influence of some fabrication parameters and operating conditions on the PCI failure occurrence in LWR fuel rods

    International Nuclear Information System (INIS)

    Bouffioux, P.

    1980-01-01

    In recent LWR designs, the fuel rod failures are induced by a chemically assisted mechanical process, i.e. stress corrosion cracking. The analytical approach towards the analysis of PCI-SCC failures is mainly based on the predictions of the COMETHE code. The failure criteria rely on the concept of a stress threshold together with fission product availability. In the present paper, the use of the COMETHE code to minimize PCI induced clad failure occurrences is illustrated by parametric studies to define acceptable fuel specifications and reactor operating conditions (steady and transient). (author)

  16. CABG Versus PCI: Greater Benefit in Long-Term Outcomes With Multiple Arterial Bypass Grafting.

    Science.gov (United States)

    Habib, Robert H; Dimitrova, Kamellia R; Badour, Sanaa A; Yammine, Maroun B; El-Hage-Sleiman, Abdul-Karim M; Hoffman, Darryl M; Geller, Charles M; Schwann, Thomas A; Tranbaugh, Robert F

    2015-09-29

    Treatment of multivessel coronary artery disease with traditional single-arterial coronary artery bypass graft (SA-CABG) has been associated with superior intermediate-term survival and reintervention compared with percutaneous coronary intervention (PCI) using either bare-metal stents (BMS) or drug-eluting stents (DES). This study sought to investigate longer-term outcomes including the potential added advantage of multiarterial coronary artery bypass graft (MA-CABG). We studied 8,402 single-institution, primary revascularization, multivessel coronary artery disease patients: 2,207 BMS-PCI (age 66.6 ± 11.9 years); 2,381 DES-PCI (age 65.9 ± 11.7 years); 2,289 SA-CABG (age 69.3 ± 9.0 years); and 1,525 MA-CABG (age 58.3 ± 8.7 years). Patients with myocardial infarction within 24 h, shock, or left main stents were excluded. Kaplan-Meier analysis and Cox regression were used to separately compare 9-year all-cause mortality and unplanned reintervention for BMS-PCI and DES-PCI to respective propensity-matched SA-CABG and MA-CABG cohorts. BMS-PCI was associated with worse survival than SA-CABG, especially from 0 to 7 years (p = 0.015) and to a greater extent than MA-CABG was (9-year follow-up: 76.3% vs. 86.9%; p PCI hazard ratios (HR) were as follows: versus SA-CABG, HR: 0.87; and versus MA-CABG, HR: 0.38. DES-PCI showed similar survival to SA-CABG except for a modest 0 to 3 years surgery advantage (HR: 1.06; p = 0.615). Compared with MA-CABG, DES-PCI exhibited worse survival at 5 (86.3% vs. 95.6%) and 9 (82.8% vs. 89.8%) years (HR: 0.45; p PCI for all comparisons (all p PCI or DES-PCI, resulted in substantially enhanced death and reintervention-free survival. Accordingly, MA-CABG represents the optimal therapy for multivessel coronary artery disease and should be enthusiastically adopted by multidisciplinary heart teams as the best evidence-based therapy. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  17. Security Assessment of Payment Systems under PCI DSS Incompatibilities

    OpenAIRE

    Bahtiyar , Şerif; Gür , Gürkan; Altay , Levent

    2014-01-01

    Part 9: Malicious Behavior and Fraud; International audience; With the ubiquitous proliferation of electronic payment systems, data and application security has become more critical for financial operations. The Payment Card Industry Data Security Standard (PCI DSS) has been developed by the payment industry to provide a widely-applicable and definitive security compliance among all components in electronic payment infrastructure. However, the security impact of PCI DSS incompatibilities and ...

  18. Design of gamma camera data acquisition system based on PCI9810

    International Nuclear Information System (INIS)

    Zhao Yuanyuan; Zhao Shujun; Liu Yang

    2004-01-01

    This paper describe the design of gamma camera's data acquisition system, which is based on PCI9810 data acquisition card of ADLink Technology Inc. The main function of PCI9810 and the program of data acquisition system are described. (authors)

  19. PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock

    NARCIS (Netherlands)

    Thiele, Holger; Akin, Ibrahim; Sandri, Marcus; Fuernau, Georg; de Waha, Suzanne; Meyer-Saraei, Roza; Nordbeck, Peter; Geisler, Tobias; Landmesser, Ulf; Skurk, Carsten; Fach, Andreas; Lapp, Harald; Piek, Jan J.; Noc, Marko; Goslar, Tomaž; Felix, Stephan B.; Maier, Lars S.; Stepinska, Janina; Oldroyd, Keith; Serpytis, Pranas; Montalescot, Gilles; Barthelemy, Olivier; Huber, Kurt; Windecker, Stephan; Savonitto, Stefano; Torremante, Patrizia; Vrints, Christiaan; Schneider, Steffen; Desch, Steffen; Zeymer, Uwe; Tebbe, Ulrich; Wöhrle, Jochen; Pachinger, Otmar; Busch, Clemens; Pfeiffer, Nathalie; Neumer, Alexander; Ouarrak, Taoufik; Reimer, Thomas; Lober, Christiane; Clemmensen, Peter; Follath, Ferenc; Wegscheider, Karl; Zeitouni, M.; Overtchouk, P.; Guedeney, P.; Hage, G.; Hauguel-Moreau, N. N.; Eitel, Ingo; Weinschenk, Sabrina; Borggrefe, Martin; Neumann, Franz-Josef; Ferenc, Miroslaw; Olbrich, Hans-Gerd; Hopf, Hans-Bernd; Kastrati, Adnan; de Waha, Antoinette; Schunkert, Heribert; Richardt, Gert; Schwarz, Bettina; Abdel-Wahab, Mohamed; Toelg, Ralph; Geist, Volker; Bahnsen-Maaß, Monika; Hennersdorf, Marcus; Graf, Jochen; Riemann, Urs; Scharpf, Dominik; Empen, Klaus; Busch, Mathias C.; Werdan, Karl; Nuding, Sebastian; Hambrecht, Rainer; Fiehn, Eduard; Gitt, Anselm K.; Mark, Bernd; Winkler, Ralph; Lauer, Bernward; Möbius-Winkler, Sven; Schulze, Christian; Minden, Hans-Heinrich; Braun-Dullaeus, Rüdiger C.; Schmeißer, Alexander; Strasser, Ruth H.; Ebner, Bernd; Ertl, Georg; Mudra, Harald; Hug, Martin; Endemann, Dierk; Hamm, Christian; Walther, Claudia; Liebetrau, Christoph; Menck, Niels; Mehilli, Julinda; Orban, Martin; Hausleiter, Jörg; Massberg, Steffen; Prondzinsky, Roland; Gielen, Stephan; Gawaz, Meinrad; Pauschinger, Matthias; Ademaj, Fadil; Bode, Christoph; Nickenig, Georg; Fichtlscherer, Stephan; Zeiher, Andreas; Viertel, Achim; Kelm, Malte; Jung, Christian; Sydow, Carsten; Karakas, Mahir; Rudolph, Volker; Baldus, Stephan; Jacobshagen, Claudius; Hasenfuß, Gerd; Pfeiffer, Dietrich; Buchter, Björn; Hügl, Burkhard; Nef, Holger; Dörr, Oliver; Reinig, Karsten; Kuck, Karl Heinz; Ghanem, Alexander; Katus, Hugo; Gori, Tommaso; Münzel, Thomas; Schnupp, Steffen; Brachmann, Johannes; Ferrari, Markus; Achenbach, Stephan; Carrié, Didier; Henry, Patrick; Manzo-Silberman, Stephane; Ledermann, Bertrand; Cayla, Guillaume; Bonnet, Jean-Louis; Windecker, Stefan; Frenk, André; Jeger, Raban; Eeckhout, Eric; Henriques, Jose P.; van Geuns, Robert-Jan; Voskuil, Michiel; Bax, M.; van der Harst, Pim; Serpytis, Rokas; Jarasuniene, Dalia; Lang, Irene Marthe; Pichler, Philipp; Weidinger, Franz; Zaruba, Marc-Michael; Dudek, Darius; Depukat, Rafal; Witkowski, Adam; Milewski, Krzysztof; Prokopczuk, Janusz; Gąsior, Mariusz; Gorycki, Bogdan; Ochała, Andrzej; Piatti, Luigi; Galvani, Marcello; Bossi, Irene; Emilia, Reggio; Pignatelli, Gianluca; Greenwood, John; Lockie, Tim; Mamas, Mamas

    2017-01-01

    In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock have multivessel disease, and whether PCI should be

  20. Suivre et contrer la circulation de l'information erronée dans le delta ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Un des pires incidents violents au Kenya depuis 2007 est survenu le 22 août 2012, lorsque 52 personnes sont mortes à la suite de violences ethniques entre des cultivateurs orma et des membres de la nation pokomo, un peuple nomade, dans le comté du fleuve Tana. Le présent projet de recherche d'une durée de deux ...

  1. El español coloquial en clase de E/LE. Actividades y consejos

    Directory of Open Access Journals (Sweden)

    David Giménez Folqués

    2016-11-01

    Full Text Available : En clase de E/LE resulta fundamental, además de trabajar el léxico general, realizar un aporte del aspecto lexicológico coloquial, en cuanto a voces y locuciones fraseológicas que supongan para el alumno un conocimiento de este ámbito, que por otro lado resultará imprescindible en el empleo del español. En primer lugar, es importante que el profesor de E/LE conozca la definición exacta de lo que significa el «español coloquial». Una vez delimitado este concepto, el siguiente paso es el de elegir y emplear actividades que resulten significativas para sus destinatarios. De esta manera, se pretende ofrecer a los docentes de esta área herramientas en forma de consejos y actividades para que puedan llevar a cabo esta labor y enseñar al alumno la importancia de aprender el léxico coloquial en su vida diaria. Palabras clave: español coloquial, lexicología coloquial, actividades E/LE.   Colloquial Spanish in E/LE class. Activities and advices   Abstract: Colloquial Spanish is essential for students of Spanish as a foreign language, in order to acquire the colloquial lexicon of the Spanish language and use it in their daily lives. Firstly, it is very important that the teacher knows the exact definition of "colloquial Spanish". The next step is to know how to choose and use activities that are significant for their students. In this sense, we want to offer useful tools and activities that they can use to teach their students the importance of learning the colloquial lexicon. Keywords: colloquial Spanish, colloquial lexicology, E/LE activities.

  2. Risk of no-reflow in culprit lesion versus culprit vessel PCI in acute STEMI.

    Science.gov (United States)

    Arslan, Uğur; Yaman, Mehmet; Kocaoğlu, İbrahim; Turan, Oğuzhan Ekrem; Yücel, Huriye; Aksakal, Aytekin; Günaydin, İlksen Atasoy; Hakan Ateş, Ahmet

    2015-09-01

    The present report describes patients with acute ST-elevation myocardial infarction who had at least two lesions in the culprit vessel (CV) during primary percutaneous coronary intervention (PCI). Here, we aimed to examine two different strategies, namely, PCI of only culprit lesion (CL) versus PCI of all lesions in the CV in the setting of acute ST-elevation myocardial infarction. Patients who underwent primary PCI were examined for the presence of an additional lesion in the infarct-related artery and divided into two groups according to the PCI strategy: CV versus CL groups. Coronary angiograms were examined for coronary thrombolysis in myocardial infarction (TIMI) flow and major clinical outcomes were determined. Of 637 patients, 472 (74.1%) underwent primary PCI for the CV (CV group) and 165 (25.9%) underwent primary PCI only for CL (CL group). TIMI flow before primary PCI and after stenting of the CL was similar; however, TIMI flow after completion of the procedure was significantly better in the CL group (P=0.022). The composite of death, nonfatal myocardial infarction and repeat revascularization was significantly better in the CL group (P=0.041) and early stent thrombosis was observed more commonly in the CV group [14 (3.0%) patients vs. 1 (0.6%) patient, P=0.09]. In the presence of an additional lesion in the CV during primary PCI, deferring stenting for the non-CL in the culprit artery after stenting the CL may be considered to prevent the development of no-reflow or slow-reflow, and thus major clinical adverse events may be reduced.

  3. Arminio nobile e la misura del cielo ovvero le disavventure di un astronomo napoletano

    CERN Document Server

    Capaccioli, Massimo

    2012-01-01

    La scienza è un’esaltante avventura che è costume raccontare attraverso le gesta dei grandi. Esiste però un’altra storia, altrettanto avvincente ma con poca voce, scritta dai tanti gregari e potenziali campioni cui la sorte, spesso nemmeno troppo cieca, ha negato la gloria. Questo libro parla di uno di loro e del suo piccolo mondo sulla collina di Capodimonte, a Napoli. È la parabola di Arminio Nobile – personaggio notevole eppure poco noto dell’astronomia italiana – svolta sulla scena della nascente astrofisica, in una stagione di grandi transizioni per il Mezzogiorno. Arminio, che era figlio di Giuseppina Guacci, figura di spicco della cultura pre-risorgimentale, e di un valente astronomo della Specola di Capodimonte, scelse di votarsi allo studio del cielo. Osservatore instancabile, appassionato e genialoide, aveva le carte in regola e le motivazioni per “sfondare”, ma la fortuna non gli arrise: più volte si beffò di lui, spingendolo su vicoli ciechi che la sua testardaggine gli impedì...

  4. L’investiture du 44e président des Etats-Unis :Le National Mall, le village global et le Green New Deal

    Directory of Open Access Journals (Sweden)

    Cynthia Ghorra-Gobin

    2009-02-01

    Full Text Available Ce texte sur les Etats-Unis est le dernier article d’une série de trois rédigés au fur et à mesure des événements à l’occasion de la 56e élection présidentielle qui a marqué l’avènement du 44e président, Barack Obama. Le premier article (juin 2008, « Un événement révélateur des mutations de la société américaine » soulignait l’originalité du sénateur candidat Obama à l’élection présidentielle de 2008 en raison de son parcours personnel face à son rival McCain. Le deuxième article (novembre 2008 « Le regard des Américains dans un contexte mondial incertain », mettait en évidence les valeurs symboliques véhiculées par le futur président Obama dans une société qui avait choisi de clore son histoire raciale. Ce troisième article s’appuyant principalement sur les images de la cérémonie d’investiture du 20 janvier 2009, le discours du président Obama et quelques commentaires des médias rend compte du sentiment de joie et de fierté d’un peuple en dépit d’une prise de conscience de la gravité d’une crise financière et économique (sans oublier les deux guerres en cours. Il illustre le choix du président en faveur d’une politique a priori en rupture avec celle de l’administration précédente en prenant l’exemple du changement climatique. Toutefois il s’interroge sur la pertinence de l’expression  « Green New Deal »  avancée par les médias en dehors de toute référence à la notion d’empreinte écologique et d’un regard réflexif sur l’American Way of Life.  This third article mainly based on the images of the inauguration ceremony (January 20th, on the president Obama’s discourse and on a few comments made by the media, describes the feeling of happiness and prideness as expressed by the American people on the National Mall in spite of the seriousness of the financial and economic crises (besides two wars. It also illustrates the choice of a president

  5. Le massacre de la mariée

    Directory of Open Access Journals (Sweden)

    Bastiaan van der Velden

    2016-06-01

    Full Text Available Le Massacre des innocents a été pour Marcel Duchamp l’une de ses sources en composant Le Grand Verre. Ce ‘massacre’ est dans ce cas plus précisément une attraction foraine. D’autre part l’infanticide à Bethlehem constitue un sujet maintes fois représenté par différents peintres. Pour Alfred Jarry, auteur littéraire et de théâtre qui a plus particulièrement inspiré Duchamp, le tableau Le Massacre des innocents de Breughel l’Ancien était une pièce clé qui lui permettait de démontrer pourquoi il rejetait l’art historisant en peinture et dans le théâtre.

  6. Real-time fusion of coronary CT angiography with x-ray fluoroscopy during chronic total occlusion PCI.

    Science.gov (United States)

    Ghoshhajra, Brian B; Takx, Richard A P; Stone, Luke L; Girard, Erin E; Brilakis, Emmanouil S; Lombardi, William L; Yeh, Robert W; Jaffer, Farouc A

    2017-06-01

    The purpose of this study was to demonstrate the feasibility of real-time fusion of coronary computed tomography angiography (CTA) centreline and arterial wall calcification with x-ray fluoroscopy during chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Patients undergoing CTO PCI were prospectively enrolled. Pre-procedural CT scans were integrated with conventional coronary fluoroscopy using prototype software. We enrolled 24 patients who underwent CTO PCI using the prototype CT fusion software, and 24 consecutive CTO PCI patients without CT guidance served as a control group. Mean age was 66 ± 11 years, and 43/48 patients were men. Real-time CTA fusion during CTO PCI provided additional information regarding coronary arterial calcification and tortuosity that generated new insights into antegrade wiring, antegrade dissection/reentry, and retrograde wiring during CTO PCI. Overall CTO success rates and procedural outcomes remained similar between the two groups, despite a trend toward higher complexity in the fusion CTA group. This study demonstrates that real-time automated co-registration of coronary CTA centreline and calcification onto live fluoroscopic images is feasible and provides new insights into CTO PCI, and in particular, antegrade dissection reentry-based CTO PCI. • Real-time semi-automated fusion of CTA/fluoroscopy is feasible during CTO PCI. • CTA fusion data can be toggled on/off as desired during CTO PCI • Real-time CT calcium and centreline overlay could benefit antegrade dissection/reentry-based CTO PCI.

  7. De Créuse à Médée (selon le Peintre de Darius

    Directory of Open Access Journals (Sweden)

    Françoise-Hélène Massa-Pairault

    2016-07-01

    Full Text Available Les héroïnes de tragédies ont un statut spécial dans le monde figuré du Peintre de Darius.  C’est le cas de Médée et de Créuse (mère d’Ion auxquelles le céramographe apulien réserve de véritables « épiphanies ». Pour quels motifs et quel est le lien entre deux héroïnes apparemment bien différentes ? L’ A. procède à un réexamen critique d’iconographies célèbres, valorisant certains détails, souvent négligés, dont la compréhension est essentielle. Le P. de Darius conçoit le lien entre ses héroïnes à travers sa connaissance des auteurs tragiques athéniens du Ve siècle, principalement d’Euripide. Or, comment et pourquoi les problèmes affrontés par Médée et Créuse, reflétant le contexte politique et social de l’Athènes classique, sont-ils susceptibles d’intéresser le public de l’artiste apulien, formé de citoyens de poleis italiotes (notamment Tarente ou par des représentants de communautés non grecques (notamment dauniennes ou peucétiennes ? L’A. esquisse aussi une réponse à ces questions en examinant les motifs guidant le Peintre de Darius lorsqu’il transpose et réactualise les débats de la polis athénienne du Ve siècle dans le contexte politique, géo-politique et social de la Grande Grèce du IVe siècle.

  8. Pellet cladding interaction (PCI) fuel duty during normal operation of ASEA-ATOM BWRs

    International Nuclear Information System (INIS)

    Vaernild, O.; Olsson, S.

    1983-01-01

    Local power changes may under special conditions cause PCI fuel failures in a power reactor. By restricting the local power increase rate in certain situations it is possible to prevent PCI failures. Fine motion control rod drives, large operating range of the main recirculation pumps and an advanced burnable absorber design have minimized the impact of the PCI restrictions. With current ICFM schemes the power of an assembly is due to the burnup of the gadolinia gradually increasing during the first cycle of operation. After this the power is essentially decreasing monotonously during the remaining life of the assembly. Some assemblies are for short burnup intervals operated at very low power in control cells. The control rods in these cells may however be withdrawn without restrictions leading to energy production losses. Base load operation would in the normal case lead to very minor PCI loads on the fuel regardless of any PCI related operating restrictions. At the return to full power after a short shutdown or in connection with load follow operation, the xenon transient may cause PCI loads on the fuel. To avoid this a few hoursholdtime before going back to full power is recommended. (author)

  9. Pellet-cladding interaction (PCI) fuel duty during normal operation of ASEA-ATOM BWRs

    International Nuclear Information System (INIS)

    Vaernild, O.; Olsson, S.

    1985-01-01

    Local power changes may, under special conditions, cause PCI fuel failures in a power reactor. By restricting the local power increase rate in certain situations it is possible to prevent PCI failures. Fine motion control rod drives, large operating range of the main recirculation pumps and an advanced burnable absorber design have minimized the impact of the PCI restrictions. With current ICFM schemes the power of an assembly is due to the burnup of the gadolinia gradually increasing during the first cycle of operation. After this the power is essentially decreasing monotonously during the remaining life of the assembly. Some assemblies are for short burnup intervals operated at very low power in control cells. The control rods in these cells may, however, be withdrawn without restrictions leading to energy production losses. Base load operation would in the normal case lead to very minor PCI loads on the fuel regardless of any PCI-related operating restrictions. At the return to full power after a short shutdown or in connection with load follow operation, the xenon transient may cause PCI loads on the fuel. To avoid this a few hours hold-time before going back to full power is recommended. (author)

  10. Effect of nicorandil on the myocardial tissue perfusion and myocardial cell injury in patients with diabetes after PCI

    Directory of Open Access Journals (Sweden)

    Xue-Li Ren1

    2017-04-01

    Full Text Available Objective: To study the effect of nicorandil on the myocardial tissue perfusion and myocardial cell damage in patients with diabetes after percutaneous coronary intervention (PCI. Methods: 68 patients with coronary heart disease and type 2 diabetes mellitus who received PCI in our hospital between May 2011 and September 2015 were collected and then divided into observation group and control group (n=34 according to the single-blind randomized control method. Control group of patients received PCI alone, and the observation group of patients received nicorandil therapy after PCI. After treatment, real-time myocardial ultrasound contrast was used to evaluate the myocardial perfusion of two groups of patients; blood biochemical analyzer was used to detect the contents of peripheral blood myocardial enzyme spectrum indexes; the ELISA method was used to detect the contents of serum oxidative stress indicators; RIA method was used to detect the contents of serum apoptosis molecules. Results: After treatment, the myocardial tissue perfusion parameters plateau peak intensity (A, slope rate of curve (β and myocardial blood flow (A×β levels of observation group were significantly higher than those of control group (P<0.05; peripheral blood myocardial enzyme spectrum indexes creatine kinase (CK, lactate dehydrogenase (LDH, troponin I (cTnI and glutamic oxalacetic transaminase (GOT contents of observation group were significantly lower than those of control group (P<0.05; serum vitamin E (VitE and vitamin C (VitC contents of observation group were significantly higher than those of control group while malondialdehyde (MDA, advanced oxidation protein products (AOPPs, soluble apoptosis-associated factor (sFas and soluble apoptosis-associated factor ligand (sFasL contents were lower than those of control group (P<0.05. Conclusion: Adjuvant nicorandil therapy can improve the myocardial perfusion and reduce the myocardial cell injury in patients with coronary

  11. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME)

    DEFF Research Database (Denmark)

    van Nunen, Lokien X; Zimmermann, Frederik M; Tonino, Pim A L

    2015-01-01

    BACKGROUND: In the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) study, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) improved outcome compared with angiography-guided PCI for up to 2 years of follow-up. The aim in this study...... was to investigate whether the favourable clinical outcome with the FFR-guided PCI in the FAME study persisted over a 5-year follow-up. METHODS: The FAME study was a multicentre trial done in Belgium, Denmark, Germany, the Netherlands, Sweden, the UK, and the USA. Patients (aged ≥ 18 years) with multivessel coronary...... artery disease were randomly assigned to undergo angiography-guided PCI or FFR-guided PCI. Before randomisation, stenoses requiring PCI were identified on the angiogram. Patients allocated to angiography-guided PCI had revascularisation of all identified stenoses. Patients allocated to FFR-guided PCI had...

  12. Coordinated CSN-UNESA research plan (PCI)

    International Nuclear Information System (INIS)

    Incinillas, J.

    2001-01-01

    This article contains a description of the essence and current status of the Coordinated Research Plan (PCI), beginning with details on the general specifications of the Framework Agreement signed by CSN and UNESA in September 1997, with an initial duration of four years and extendable on a yearly basis. The section on PCI Management describes the governing bodies, the mechanisms for including a project, tracking of projects underway, and the mechanisms for concluding projects. The Plan's generic goals are to acquire and increase technological skills and tools to guarantee operation of the nuclear park, take advantage of the synergies of the plants as a whole, and optimize the regulatory framework from the standpoint of safety and efficiency. In addition, strategic targets concerning efficiency, technological development and environment are defined. The current project status, overall budget and project completed to data are described. (Author)

  13. La serrata e le altre forme di lotta sindacale

    Directory of Open Access Journals (Sweden)

    Marina Nicolosi

    2011-12-01

    Full Text Available Sommario: 1. Premessa: definizione della serrata e tipologie. – 2. Il dato normativo: il silenzio della Costituzione e la sentenza della Corte Costituzionale n. 29/1960. - 3. La rile­vanza penale della serrata. – 4. La rilevanza civile della serrata “per fini contrattuali”. – 5. La serrata di ritorsione. - 6. La serrata di rea­zione come comportamento antisindacale. - 7. Le altre forme di lotta sindacale. – 8. Il pic­chettaggio. – 9. L’occupazione d’azienda. – 10. Il boicottaggio e il sabotaggio.

  14. The risk of PCI damage to 8x8 fuel rods during limit cycle instability

    Energy Technology Data Exchange (ETDEWEB)

    Schrire, D.; Oguma, R.; Malen, K.

    1994-12-31

    A BWR reactor core may experience thermal-hydraulic instability under certain operating conditions. Generally, the instability results in neutron flux (i e generated neutronic power) and coolant flow and pressure oscillations, which reach a maximum `limit cycle` amplitude. The cladding response to power transients has been studied using noise analysis. These results have been compared to results from code calculations using the fuel code TOODEE 2. From these results the risk for fuel rod failure due to pellet-clad mechanical interaction and possible failure due to stress corrosion cracking (PCI) has been estimated. It turns out that for the oscillation frequencies of interest (0,3-0,5 Hz) the fuel response amplitude reduction makes PCI-failure improbable. 17 refs.

  15. Scuola, infanzie e culture in Quebec. Le politiche educative interculturali dal paradigma culturalista al paradigma civico

    Directory of Open Access Journals (Sweden)

    Letizia Caronia

    2009-07-01

    Full Text Available Questo articolo propone un’analisi storica e una riflessione critica sui modi con cui il Quebec ha affrontato e costantemente riaffronta il problema della scuola pubblica in una società storicamente multiculturale, multietnica e plurilingue. In particolare, la riflessione riguarda il piano normativo e legislativo e le politiche scolastiche via via elaborate, per rispondere alla sfida di pensare e costruire una scuola pubblica capace di costruire una “infanzia quebecchese”. Una lettura del’curricolo ideale’ - si dirà - ci dice poco sulla ‘realtà’ educativa di un paese. Eppure, in Quebec come altrove, le politiche scolastiche costituiscono i segnali pubblici del modo con cui un paese – rappresentando pubblicamente e ufficialmente la sua scuola - rappresenta se stesso, i propri valori, le proprie concezioni di ‘infanzia’. Dopo un breve quadro storico inteso a tracciare l’origine multiculturale del Quebec (come di tutti gli stati nordamericani, par.1, saranno presi in esame la legge 101 (1977 che sancisce il francese come lingua ufficiale di insegnamento e il dibattito sempre vivo e lacerante che ha accompagnato questa legge e le sue successive modifiche (parr. 2-4. In secondo luogo, saranno presi in esame il recente processo di laicizzazione della scuola quebecchese sancito dalla legge 118 (giugno 2000 e le profonde implicazioni culturali, politiche e identitarie di tale processo (parr. 5-8. In un paese che storicamente ha fatto un uso a carattere esplicitamente identitario del riferimento alle religioni dei due gruppi maggioritari, che ha costruito su esso la propria organizzazione sociale, le identità dei gruppi e i loro rapporti di forza, la deconfessionalizzazione della scuola pubblica ha implicazioni e significati culturali del tutto peculiari. Infine sarà analizzata l’assunzione ufficiale della vocazione interculturale della scuola pubblica (parr. 9-11. L’incrocio di questi tagli prospettici fa emergere i

  16. Cristine de Pizan e le emozioni per la Cità des Dames

    Directory of Open Access Journals (Sweden)

    Angela Giallongo

    2011-06-01

    Full Text Available L’interesse storico per le emozioni spinge ad interrogarsi sul loro ruolo nelle utopie femminili alla fine del medioevo. Una fonte centrale su questo tema è l’opera illustrata la Cité des Dames (1405 di C. de Pizan (1365-1430. Gli studi di B.H. Rosenwein, W. Reddie e K.Oatley forniscono categorie interpretative psico-sociali (comunità emotive e regime emotivo utili per connettere l’idea di utopia, valori emotivi e rapporti interpersonali fra i sessi. La problematicizzazione, suggerita da Rosenwein, della comunità immaginata come comunità emotiva aiuta a identificare i modi di sentire rifiutati e quelli privilegiati per l’espressione del senso di sé e per la costruzione della città ideale, offerta alle donne di tutte le classi sociali.In conclusione, l’analisi qualitativa dell’opera della de Pizan focalizza l’uso formativo delle immagini mitiche, l’esperienza dell’autrice, contestualizzata nel periodo, e i significati culturali attribuiti alle “emozioni”.

  17. Le corps sportif1

    OpenAIRE

    Brulé, Pierre

    2015-01-01

    Le nu et le cuit Si, pas plus que l’Auvergne, le monde grec antique n’a été le théâtre d’un quelconque « miracle », il n’a pas manqué, toutefois, de « distinctions » diverses, d’exceptions même, qui le singularisent absolument. Une, c’est la pédérastie. Quelle culture l’a autant valorisée, autant instrumentalisée, l’a autant érigée en modèle ? Nous n’en avons pas encore mesuré toutes les conséquences. La place inhabituelle que prend là et alors cette polyvalence rare de la libido masculine de...

  18. Potential of Pseudomonas putida PCI2 for the Protection of Tomato Plants Against Fungal Pathogens.

    Science.gov (United States)

    Pastor, Nicolás; Masciarelli, Oscar; Fischer, Sonia; Luna, Virginia; Rovera, Marisa

    2016-09-01

    Tomato is one of the most economically attractive vegetable crops due to its high yields. Diseases cause significant losses in tomato production worldwide. We carried out Polymerase Chain Reaction studies to detect the presence of genes encoding antifungal compounds in the DNA of Pseudomonas putida strain PCI2. We also used liquid chromatography-electrospray tandem mass spectrometry to detect and quantify the production of compounds that increase the resistance of plants to diseases from culture supernatants of PCI2. In addition, we investigated the presence of 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase in PCI2. Finally, PCI2 was used for inoculation of tomato seeds to study its potential biocontrol activity against Fusarium oxysporum MR193. The obtained results showed that no fragments for the encoding genes of hydrogen cyanide, pyoluteorin, 2,4-diacetylphloroglucinol, pyrrolnitrin, or phenazine-1-carboxylic acid were amplified from the DNA of PCI2. On the other hand, PCI2 produced salicylic acid and jasmonic acid in Luria-Bertani medium and grew in a culture medium containing ACC as the sole nitrogen source. We observed a reduction in disease incidence from 53.33 % in the pathogen control to 30 % in tomato plants pre-inoculated with PCI2 as well as increases in shoot and root dry weights in inoculated plants, as compared to the pathogenicity control. This study suggests that inoculation of tomato seeds with P. putida PCI2 increases the resistance of plants to root rot caused by F. oxysporum and that PCI2 produces compounds that may be involved at different levels in increasing such resistance. Thus, PCI2 could represent a non-contaminating management strategy potentially applicable in vegetable crops such as tomato.

  19. Giorgio Perlasca, 'Giusto tra le nazioni' e 'eroe italiano'

    NARCIS (Netherlands)

    Jansen, M.M.

    2008-01-01

    Giorgio Perlasca che, fingendosi console spagnolo, nel 1944 salvò più di cinquemila ebrei ungheresi a Budapest, è stato proclamato “Giusto tra le Nazioni” a Yad Vashem nel 1989, dopo di che è seguito il suo riconoscimento all’estero ed in Italia come “uomo giusto” e come “eroe italiano”. Dopo il

  20. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  1. Con le galoches, Basaglia e Don Milani, a spasso per la Via Lattea: cooperazione educativa, pedagogia del Cielo e politica dell’esperienza

    Directory of Open Access Journals (Sweden)

    Anna Barracco

    2017-08-01

    Full Text Available L'articolo riporta, a caldo, i pensieri, le riflessioni e le emozioni della psicoanalista e past president del Cipra, Anna Barracco, che scaturiscono dopo aver preso parte a un'esperienza di aggiornamento professionale sperimentale, rivolto agli insegnanti e promosso dal Movimento per la Cooperazione Educativa, svoltasi a Gubbio, dal 21 al 23 Aprile 2017. Il progetto è volutamente interdisciplinare e aperto a tutti, ma per lo più accoglie insegnanti della scuola dell'infanzia e della primaria. L'autrice mette in valore l'eredità spirituale e filosofica di Don Milani e della Scuola di Barbiana, eredità che appare molto viva nei gesti e negli stili che caratterizzano il seminario. Barracco ritrova, non senza un velo di malinconia, la forza e il respiro utopistico di un approccio che scavalca la dissimmetria fra discente e docente, dove tutti sono in qualche modo allievi - o ricercatori - del Cielo, cioè della materia che si vuole osservare, ma della quale siamo parte: il Cielo come sfondo integratore, in senso didattico, certamente, ma in senso anche esistenziale e filosofico. Un’esperienza di apprendimento e di comunità, che l'autrice mette in tensione con le esperienze basagliane e con la necessità di ritrovare un più fattivo dialogo fra le professioni umanistiche della cura e dell'educazione, indicando come strumento la messa in gioco del proprio desiderio di apprendere dall'esperienza, di guardare alle cose e alle persone, senza che lo schermo di tutto quello che crediamo di sapere ci impedisca di vedere.

  2. Real-time fusion of coronary CT angiography with X-ray fluoroscopy during chronic total occlusion PCI

    Energy Technology Data Exchange (ETDEWEB)

    Ghoshhajra, Brian B.; Takx, Richard A.P. [Harvard Medical School, Cardiac MR PET CT Program, Massachusetts General Hospital, Department of Radiology and Division of Cardiology, Boston, MA (United States); Stone, Luke L.; Yeh, Robert W.; Jaffer, Farouc A. [Harvard Medical School, Cardiac Cathetrization Laboratory, Cardiology Division, Massachusetts General Hospital, Boston, MA (United States); Girard, Erin E. [Siemens Healthcare, Princeton, NJ (United States); Brilakis, Emmanouil S. [Cardiology Division, Dallas VA Medical Center and UT Southwestern Medical Center, Dallas, TX (United States); Lombardi, William L. [University of Washington, Cardiology Division, Seattle, WA (United States)

    2017-06-15

    The purpose of this study was to demonstrate the feasibility of real-time fusion of coronary computed tomography angiography (CTA) centreline and arterial wall calcification with X-ray fluoroscopy during chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Patients undergoing CTO PCI were prospectively enrolled. Pre-procedural CT scans were integrated with conventional coronary fluoroscopy using prototype software. We enrolled 24 patients who underwent CTO PCI using the prototype CT fusion software, and 24 consecutive CTO PCI patients without CT guidance served as a control group. Mean age was 66 ± 11 years, and 43/48 patients were men. Real-time CTA fusion during CTO PCI provided additional information regarding coronary arterial calcification and tortuosity that generated new insights into antegrade wiring, antegrade dissection/reentry, and retrograde wiring during CTO PCI. Overall CTO success rates and procedural outcomes remained similar between the two groups, despite a trend toward higher complexity in the fusion CTA group. This study demonstrates that real-time automated co-registration of coronary CTA centreline and calcification onto live fluoroscopic images is feasible and provides new insights into CTO PCI, and in particular, antegrade dissection reentry-based CTO PCI. (orig.)

  3. The foundation of NCVD PCI Registry: the Malaysia's first multi-centre interventional cardiology project.

    Science.gov (United States)

    Liew, H B; Rosli, M A; Wan Azman, W A; Robaayah, Z; Sim, K H

    2008-09-01

    The National Cardiovascular Database for Percutaneous Coronary Intervention (NCVD PCI) Registry is the first multicentre interventional cardiology project, involving the main cardiac centres in the country. The ultimate goal of NCVD PCI is to provide a contemporary appraisal of PCI in Malaysia. This article introduces the foundation, the aims, methodology, database collection and preliminary results of the first six-month database.

  4. I centri diurni e le esigenze del paziente: apprendere dall'esperienza

    Directory of Open Access Journals (Sweden)

    Laura Tussi

    2005-06-01

    Full Text Available Relazione riassuntiva in occasione dell'incontro organizzato e promosso dall'Associazione A.R.P.A. riguardante le psicosi ed il contributo di Giovanni Carlo Zapparoli presso la Casa della Cultura di Milano.

  5. An Experimental Research on the pCI Rule and Causal Judgment (in Chinese)

    OpenAIRE

    Shao, Z. F.; Wang, J.

    2005-01-01

    This research examined the precision of the pCI rule through three experiments. The results show that first , the tendency of the subjects’ casual judgments was basically similar to the pCI rule. But (a + d) / n predicted human’s casual judgments were even better; second, the increase of subjects’ casual judgments was milder than the pCI rule, and the subjects needed time to construct their own way of judging relationship; finally, different people had different ways of causal judgments, and ...

  6. Effect of intracoronary injection of tirofiban combined with anisodamine on myocardial perfusion in patients with STEMI after PCI

    Directory of Open Access Journals (Sweden)

    Xiao-Gang Zhu

    2016-10-01

    Full Text Available Objective: To analyze the effect of intracoronary injection of tirofiban combined with anisodamine on myocardial perfusion in patients with STEMI after PCI. Methods: A total of 78 patients with acute ST segment elevation myocardial infarction (STEMI who received PCI therapy in our hospital were randomly divided into control group and observation group, control group accepted routine PCI treatment, observation group received intracoronary injection of tirofiban and anisodamine in PCI, and myocardial perfusion of two groups was compared. Results: QRS duration values of observation group the instant after PCI and 4h after PCI were less than those of control group (P<0.05; 99mTc-MIBI and 18F-FDG intake of observation group after PCI were more than those of control group (P<0.05; serum MCP-1, sFas, Copeptin, OPN and vWF levels of observation group 4 h after PCI were lower than those of control group (P<0.05. Conclusions: Intracoronary injection of tirofiban combined with anisodamine can optimize myocardial perfusion in patients with STEMI after PCI, and has positive clinical significance.

  7. Parallel data grabbing card based on PCI bus RS422

    International Nuclear Information System (INIS)

    Zhang Zhenghui; Shen Ji; Wei Dongshan; Chen Ziyu

    2005-01-01

    This article briefly introduces the developments of the parallel data grabbing card based on RS422 and PCI bus. It could be applied for grabbing the 14 bits parallel data in high speed, coming from the devices with RS422 interface. The methods of data acquisition which bases on the PCI protocol, the functions and their usages of the chips employed, the ideas and principles of the hardware and software designing are presented. (authors)

  8. Are PCI Service Volumes Associated with 30-Day Mortality? A Population-Based Study from Taiwan.

    Science.gov (United States)

    Yu, Tsung-Hsien; Chou, Ying-Yi; Wei, Chung-Jen; Tung, Yu-Chi

    2017-11-09

    The volume-outcome relationship has been discussed for over 30 years; however, the findings are inconsistent. This might be due to the heterogeneity of service volume definitions and categorization methods. This study takes percutaneous coronary intervention (PCI) as an example to examine whether the service volume was associated with PCI 30-day mortality, given different service volume definitions and categorization methods. A population-based, cross-sectional multilevel study was conducted. Two definitions of physician and hospital volume were used: (1) the cumulative PCI volume in a previous year before each PCI; (2) the cumulative PCI volume within the study period. The volume was further treated in three ways: (1) a categorical variable based on the American Heart Association's recommendation; (2) a semi-data-driven categorical variable based on k-means clustering algorithm; and (3) a data-driven categorical variable based on the Generalized Additive Model. The results showed that, after adjusting the patient-, physician-, and hospital-level covariates, physician volume was associated inversely with PCI 30-day mortality, but hospital volume was not, no matter which definitions and categorization methods of service volume were applied. Physician volume is negatively associated with PCI 30-day mortality, but the results might vary because of definition and categorization method.

  9. Le père ou le roi : Stratégies de traduction en Ésaïe IX, 6 et XXII, 21 (Septante

    Directory of Open Access Journals (Sweden)

    Philippe Le Moigne

    2008-12-01

    Full Text Available La Septante (traduction grecque ancienne de la Bible hébraïque d’Ésaïe refuse deux fois à un personnage le nom de « père » que lui accordait le texte hébreu ; en même temps, elle crée à ces personnages des traits royaux, ou les accentue. Il est possible que le traducteur ait voulu éviter d’attribuer à un être humain le qualificatif honorifique de « père », qu’il réserverait ainsi à Dieu.The Septuagint (the former Greek translation of the Hebraic Bible of Isaias refuses twice to a person the name « father » which the Hebrew text gave him; at the same time, it creates for these people royal features, or stresses them. It is possible that the translator wanted to avoid attributing to a human being the honorary term of « father », that he would so reserve for God.

  10. The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

    Science.gov (United States)

    2011-01-01

    Introduction The aim was to determine the effect of the Bruton tyrosine kinase (Btk)-selective inhibitor PCI-32765, currently in Phase I/II studies in lymphoma trials, in arthritis and immune-complex (IC) based animal models and describe the underlying cellular mechanisms. Methods PCI-32765 was administered in a series of murine IC disease models including collagen-induced arthritis (CIA), collagen antibody-induced arthritis (CAIA), reversed passive anaphylactic reaction (RPA), and passive cutaneous anaphylaxis (PCA). Clinical and pathologic features characteristic of each model were examined following treatment. PCI-32765 was then examined in assays using immune cells relevant to the pathogenesis of arthritis, and where Btk is thought to play a functional role. These included proliferation and calcium mobilization in B cells, cytokine and chemokine production in monocytes/macrophages, degranulation of mast cells and its subsequent cytokine/chemokine production. Results PCI-32765 dose-dependently and potently reversed arthritic inflammation in a therapeutic CIA model with an ED50 of 2.6 mg/kg/day. PCI-32765 also prevented clinical arthritis in CAIA models. In both models, infiltration of monocytes and macrophages into the synovium was completely inhibited and importantly, the bone and cartilage integrity of the joints were preserved. PCI-32765 reduced inflammation in the Arthus and PCA assays. In vitro, PCI-32765 inhibited BCR-activated primary B cell proliferation (IC50 = 8 nM). Following FcγR stimulation, PCI-32765 inhibited TNFα, IL-1β and IL-6 production in primary monocytes (IC50 = 2.6, 0.5, 3.9 nM, respectively). Following FcεRI stimulation of cultured human mast cells, PCI-32765 inhibited release of histamine, PGD2, TNF-α, IL-8 and MCP-1. Conclusions PCI-32765 is efficacious in CIA, and in IC models that do not depend upon autoantibody production from B cells. Thus PCI-32765 targets not only B lymphocytes but also monocytes, macrophages and mast cells

  11. PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI

    DEFF Research Database (Denmark)

    Hjortebjerg, Rikke; Lindberg, Søren; Hoffmann, Søren

    2015-01-01

    -segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). Prior to PCI, patients were injected with 10,000IU of unfractionated heparin (UFH). Blood samples were collected immediately before PCI, but after UFH-injection, immediately after PCI and on day 1 and day 2....... Plasma IGFBP-4, CT-IGFBP-4 and NT-IGFBP-4 levels were determined by specific, novel immunoassays, and PAPP-A and IGF-I by commercial immunoassays. RESULTS: Plasma PAPP-A was strongly elevated upon STEMI, UFH-administration and PCI with mean concentrations (95%-confidence interval) pre-PCI, post-PCI, day...... 1, and day 2 of 13.0 (11.2;15.2), 14.8 (13.1;16.8), 1.03 (0.90;1.18), and 1.08 (0.92;1.28) μg/L, respectively (pPCI concentrations of IGFBP-4, CT-IGFBP-4 and NT-IGFBP-4 were 154 (142;166), 53 (47;60) and 136 (122;150) μg/L, and levels were unaltered post-PCI. Concentrations increased...

  12. APC-PCI complex levels for screening of AAA in patients with peripheral atherosclerosis.

    Science.gov (United States)

    Zarrouk, Moncef; Keshavarz, Kave; Lindblad, Bengt; Gottsäter, Anders

    2013-11-01

    To evaluate the use of activated protein C-protein C inhibitor (APC-PCI) complex levels for detection of abdominal aortic aneurysm (AAA) in patients with peripheral atherosclerotic disease (PAD). APC-PCI levels and aortic diameter evaluated in 511 PAD patients without previously known AAA followed-up concerning survival for 4.8(0.5) years. AAA was found in 13% of patients. Aortic diameter correlated (r = 0.138; p = 0.002) with APC-PCI levels which were higher (0.40[0.45] vs. 0.30[0.49] μg/l; p = 0.004) in patients with AAA. This difference persisted in multivariate analysis (p = 0.029). A threshold value of APC-PCI ≥0.15 μg/L showed a specificity of 11%, a sensitivity of 97% and a negative predictive value of 96% for an AAA diagnosis. APC-PCI levels were higher in patients with AAA, and showed high sensitivity but low specificity for the diagnosis and can therefore not be considered as a screening tool in PAD patients. An AAA prevalence of 13% in patients with PAD indicates a need for AAA screening within this population.

  13. Primary pci in st elevation myocardial infarction : an experience at afic/nihd rawalpindi

    International Nuclear Information System (INIS)

    Saif, M.; Khan, H.S.; Kha, M.N.; Maken, G.R.

    2013-01-01

    Objective: To evaluate the practicability, safety, and efficacy of primary percutaneous coronary intervention as a therapeutic option in acute ST elevation Myocardial Infarction (STEMI). Study Design: Descriptive study. Place and Duration of Study: The study was carried out in Armed Forces Institute of Cardiology- National Institute of Heart Diseases (AFIC-NIHD) from 18th October 2011 to 30th November 2011. Patients and Methods: All patients presenting with acute STEMI were offered primary PCI. Patients who chose primary PCI as a mode of reperfusion were included in the study. Informed consent was taken and detailed questionnaire was filled for those patients who fulfilled the study criteria. Results: Our initial experience of primary PCI in 33 patients with ST elevation MI has revealed some favourable statistics. Only 01 (3.0%) patient died during hospital stay following the procedure. Thirty two (97%) patients had an uneventful recovery and were successfully discharged 48-72 hours following PCI. Conclusion: We have shown that primary PCI is a viable therapeutic option and can be performed in public sector tertiary care hospitals with excellent immediate, short and long term outcomes despite relatively long symptom onset to emergency room and door-to-balloon times. (author)

  14. PCI Based Read-out Receiver Card in the ALICE DAQ System

    CERN Document Server

    Carena, W; Dénes, E; Divià, R; Schossmaier, K; Soós, C; Sulyán, J; Vascotto, Alessandro; Van de Vyvre, P

    2001-01-01

    The Detector Data Link (DDL) is the high-speed optical link for the ALICE experiment. This link shall transfer the data coming from the detectors at 100 MB/s rate. The main components of the link have been developed: the destination Interface Unit (DIU), the Source Interface Unit (SIU) and the Read-out Receiver Card (RORC). The first RORC version is based on the VME bus. The performance tests show that the maximum VME bandwidth could be reached. Meanwhile the PCI bus became very popular and is used in many platforms. The development of a PCI-based version has been started. The document describes the prototype version in three sections. An overview explains the main purpose of the card: to provide an interface between the DDL and the PCI bus. Acting as a 32bit/33MHz PCI master the card is able to write or read directly to or from the system memory from or to the DDL, respectively. Beside these functions the card can also be used as an autonomous data generator. The card has been designed to be well adapted to ...

  15. Être et exister: le cas de La Nausée

    NARCIS (Netherlands)

    Buuren, M.B. van

    2007-01-01

    Dans La Nausée, Jean-Paul Sartre oppose ‘exister’ à ‘être’. Exister, c’est la contingence, c’est la facticité, c’est la matière qui étouffe petit à petit Antoine Roquentin. L’existence lui inspire angoisse, répulsion et nausée. L’être, pale lueur d’espoir, s’y oppose comme le domaine de

  16. Experimental investigation of mouse kidney aging with SR PCI technology

    Science.gov (United States)

    Yifeng, P.; Zehua, Z.; Guohao, D.; Tiqiao, X.; Hongjie, X.; Peiping, Z.

    2013-08-01

    Objective. Basing on the coherence character of the Synchrotron radiation (SR), the mouse kidney study is performed using the propagation-based phase-contrast imaging (PCI) technology which as one approach of the phase contrasts imaging (PCI). The aim of this paper was to visualize the kidney at different ages and evaluate the latent value of aging mechanism with SR phase contrast imaging technology. Methods. The experiments were performed at the BL13W1 line of the SSRF (the Shanghai synchrotron radiation facility), the samples were soaked in 10% formalin solution, the mouse kidneys at different ages were imaged on the shelf in the propagation-based phase-contrast imaging setup and captured with CCD. The captured images were analyzed and compared. Results. When the distance is 50 cm between the samples and imaging plate, good contrast and high resolution were obtained in the propagation-based phase-contrast imaging (PCI), as such renal capsule revealed well, and the resolution reach to 30 micron; there is significant difference in the shape and vessels structures among the mouse kidneys at different age. Conclusion. The PCI is good for the applying of main light element organization imaging, the difference in shape and vessels structure between the young and old mouse kidney maybe indicated at some extent with the propagation-based phase-contrast imaging technology.

  17. Mobilità Urbana Sostenibile: strategie attuali e nuove sfide per le città europee

    Directory of Open Access Journals (Sweden)

    Adriana Galderisi

    2011-07-01

    Full Text Available Nel decennio 2001-2010 numerosi passi sono stati compiuti dall’Unione Europea per orientare le città europee verso forme di mobilità sostenibile. Finalità comune alle numerose iniziative messe in campo dall’UE è stata quella di promuovere, soprattutto nelle aree urbane, un aumento della mobilità – indispensabile per lo sviluppo competitivo delle città e per garantire ai cittadini elevate opportunità di accesso alle dotazioni urbane – e una contemporanea drastica riduzione dei significativi costi ambientali che ad essa risultano, a tutt’oggi, associati.Strategie, iniziative e ricerche in ambito europeo sono state orientate, nel corso del decennio 2001-2010, a promuovere una sostanziale limitazione del trasporto individuale su gomma all’interno delle aree urbane e ad incentivare forme di mobilità sostenibile. Più specificamente, strategie e azioni sono state prioritariamente rivolte a: favorire innovazioni relative ai modi e ai mezzi del trasporto urbano; garantire un riequilibrio intermodale all’interno delle aree urbane, favorendo il trasporto pubblico, soprattutto su ferro, e gli spostamenti pedonali e ciclabili; superare la settorialità che ha a lungo caratterizzato la pianificazione dei trasporti, delineando processi di governo basati sull’integrazione tra politiche e strumenti per la pianificazione della città, dei trasporti e dell’ambiente (Galderisi, 2007. A partire dal 2007, l’Unione Europea ha ulteriormente e significativamente intensificato il proprio impegno per una riduzione dei costi ambientali della mobilità urbana: dal Libro Verde sul Trasporto Urbano, al Patto dei Sindaci mirato a coinvolgere attivamente le città europee nel percorso verso la sostenibilità energetica ed ambientale e, ancora, al più recente Libro Bianco sui Trasporti del 2011, numerose sono state le iniziative messe in campo dall’Unione Europea per dare concretezza e operatività agli indirizzi già delineati nel Libro Bianco

  18. «Il Pci è un partito finito». Video-documentario sulla scomparsa della “piazza rossa”

    Directory of Open Access Journals (Sweden)

    Gisella Gaspari

    2013-05-01

    Full Text Available Attraverso immagini di manifestazioni a sfondo politico nelle piazze di Bologna, il video-documentario illustra una trasformazione delle forme di partecipazione collettiva alla vita pubblica, che negli anni Settanta ha visto un ridimensionamento del ruolo dei partiti di massa, e in particolare del Pci.

  19. Compte-rendu de la journée d'étude de l'ATALA à Grenoble le 22 octobre 2004

    Directory of Open Access Journals (Sweden)

    Lionel Lamadon

    2004-12-01

    Full Text Available La journée d'étude de l'ATALA (Association pour le Traitement Automatique de la Langue s'est déroulée le 22 octobre 2004 à l'université Stendhal Grenoble 3 et avait pour thème : TAL et apprentissage des langues. Cette journée était organisée par le LIDILEM (Laboratoire de Linguistique et Didactique des Langues Étrangères et Maternelles de l'université Stendhal, sous l'égide de l'ATALA et avec le soutien de XRCE (Xerox Research Centre Europe et du projet européen Thetis. Un nombre important de soumissions a permis d'emblée de mesurer l'intérêt suscité par le thème de cette journée. Au final, dix articles ont été sélectionnés pour une présentation orale ainsi que quatre articles pour la session posters. Autour de la thématique générale des liens entre le TAL (Traitement Automatique de la Langue et l'ALAO (Apprentissage des Langues Assisté par Ordinateur, les intervenants ont présenté différents axes de recherche permettant de mieux cerner les enjeux de l'intégration d'outils de TAL dans des environnements informatiques d'aide à l'apprentissage.

  20. 100 Gbps PCI-Express readout for the LHCb upgrade

    International Nuclear Information System (INIS)

    Durante, P.; Neufeld, N.; Schwemmer, R.; Balbi, G.; Marconi, U.

    2015-01-01

    We present a new data acquisition system under development for the next upgrade of the LHCb experiment at CERN. We focus in particular on the design of a new generation of readout boards, the PCIe40, and on the viability of PCI-Express as an interconnect technology for high speed readout. We show throughput measurements across the PCI-Express bus, on Altera Stratix 5 devices, using a DMA mechanism and different synchronization schemes between the FPGA and the readout unit. Finally we discuss hardware and software design considerations necessary to achieve a data throughput of 100 Gbps in the final readout board

  1. Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice.

    Science.gov (United States)

    Sellevold, Simen; Peng, Qian; Fremstedal, Ane Sofie Viset; Berg, Kristian

    2017-12-01

    Photochemical internalization (PCI) is a novel technique for delivery of active macromolecules into cancerous cells, via light activation of a specific photosensitizer and a low dose systemic drug. Numerous pre-clinical studies and one clinical trial have confirmed the treatment potential in carcinomas. Soft tissue sarcomas are rare and generally resistant to radio- and chemotherapy. Due to treatment resistance and surgical morbidity in sarcoma care, we seek to increase knowledge on PCI effects in sarcomas by studying two different, but closely related leiomyosarcomas. MES-SA and SK-LMS-1 tumours were established in the leg muscles of athymic mice. Treatment effects after AlPcS 2a -PCI of bleomycin, PCI with no drug (photodynamic therapy, PDT) and control groups were evaluated by: 1) assessment of tumour growth, 2) uptake of contrast agent during MRI and 3) histopathology. PCI of bleomycin induced a similar and significant increase in time to reach the end point in both tumour models, while neither responded to AlPcS 2a -PDT. In the MES-SA tumours PCI reduced the growth rate, while in the SK-LMS-1 tumours the growth was blocked for 12days followed by exponential growth close to that of untreated tumours. SK-LMS-1 tumours were more homogenously and better vascularized than MES-SA. After PCI the vascular shutdown was more complete in the SK-LMS-1 tumours than in the MES-SA tumours. AlPcS2a-based PCI, but not PDT, induced significant tumour growth delay in the evaluated sarcomas. Cellular responsiveness to bleomycin and tumour vascularity are identified as predictive markers for PCI treatment effects. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. La “morte digitale”, le nuove forme di commemorazione del lutto online e il ripensamento delle idee di morte e d’immortalità

    OpenAIRE

    Ziccardi, Giovanni

    2017-01-01

    SOMMARIO: 1. Premessa: la “morte digitale” - 2. Le piattaforme tecnologiche, il diritto e la gestione degli utenti defunti - 3. La morte “in diretta” e la condivisione online del lutto - 4. Il fenomeno dei selfie funerari - 5. Le cerimonie funebri trasmesse in live streaming - 6. L’evoluzione del lutto: da offline a online - 7. Il ripensamento collettivo in corso - 8. L’immortalità tecnologica - 9. Il problema della “dipendenza” e della “confusione” - 10. Alcune considerazioni conclusive....

  3. pour le trimestre qui a pris fin le 30 juin 2015

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    30 juin 2015 ... Le CRDI finance des travaux de recherche appliquée ... recherches pour le développement international (le Centre) et de ..... voie de développement et sur la mise en oeuvre des connaissances scientifiques, techniques et autres en .... Les accords expirent à des dates différentes, et le dernier prend fin en.

  4. PCI is Not Predictive of Survival After Complete CRS/HIPEC in Peritoneal Dissemination from High-Grade Appendiceal Primaries.

    Science.gov (United States)

    Votanopoulos, Konstantinos Ioannis; Bartlett, David; Moran, Brendan; Haroon, Choudry M; Russell, Greg; Pingpank, James F; Ramalingam, Lekshmi; Kandiah, Chandrakumaran; Chouliaras, Konstantinos; Shen, Perry; Levine, Edward A

    2018-03-01

    Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is a treatment option in patients with carcinomatosis from high-grade appendiceal (HGA) primaries. It is unknown if there is a Peritoneal Carcinomatosis Index (PCI) upper limit above which a complete CRS/HIPEC does not assure long-term survival. Retrospective analysis from three centers was performed. The PCI was used to grade volume of of disease. Survival in relation to PCI was studied on patients with complete cytoreduction. Overall, 521 HGA patients underwent CRS/HIPEC from 1993 to 2015, with complete CRS being achieved in 50% (260/622). Mean PCI was 14.8 (standard deviation 8.7, range 0-36). Median survival for the complete CRS cohort was 6.1 years, while 5- and 10-year survival was 51.7% (standard error [SE] 4.6) and 36.1% (SE 6.3), respectively. Arbitrary cut-off PCI limits with 5-point splits (p = 0.63) were not predictive of a detrimental effect on survival as long as a complete CRS was achieved. A linear effect of the PCI on survival (p = 0.62) was not observed, and single-point PCI cohort splits within a PCI range of  10 were not predictive of survival for complete CRS patients. The PCI correlated with the ability to achieve a complete CRS, with a mean PCI of 14.7 (8.7) for completeness of cytoreduction (CC)0, 22.3 (7.8) for CC1 and 26.1 (9.5) for CC2/3 resections (p = 0.0001, hazard ratio 1.12, 95% confidence interval 1.09), with an HR of 1.15 for each 1-unit increase in the PCI score. Only 21% of the cohort achieved a complete CRS with a PCI ≥ 21. The PCI correlates with the ability to achieve a complete CRS in carcinomatosis from HGA. PCI is not associated with survival as long as a complete CRS can be achieved.

  5. Demonstration of the Safety and Feasibility of Robotically Assisted Percutaneous Coronary Intervention in Complex Coronary Lesions: Results of the CORA-PCI Study (Complex Robotically Assisted Percutaneous Coronary Intervention).

    Science.gov (United States)

    Mahmud, Ehtisham; Naghi, Jesse; Ang, Lawrence; Harrison, Jonathan; Behnamfar, Omid; Pourdjabbar, Ali; Reeves, Ryan; Patel, Mitul

    2017-07-10

    The aims of this study were to evaluate the feasibility and technical success of robotically assisted percutaneous coronary intervention (R-PCI) for the treatment of coronary artery disease (CAD) in clinical practice, especially in complex lesions, and to determine the safety and clinical success of R-PCI compared with manual percutaneous coronary intervention (M-PCI). R-PCI is safe and feasible for simple coronary lesions. The utility of R-PCI for complex coronary lesions is unknown. All consecutive PCI procedures performed robotically (study group) or manually (control group) over 18 months were included. R-PCI technical success, defined as the completion of the procedure robotically or with partial manual assistance and without a major adverse cardiovascular event, was determined. Procedures ineligible for R-PCI (i.e., atherectomy, planned 2-stent strategy for bifurcation lesion, chronic total occlusion requiring hybrid approach) were excluded for analysis from the M-PCI group. Clinical success, defined as completion of the PCI procedure without a major adverse cardiovascular event, procedure time, stent use, and fluoroscopy time were compared between groups. A total of 315 patients (mean age 67.7 ± 11.8 years; 78% men) underwent 334 PCI procedures (108 R-PCIs, 157 lesions, 78.3% type B2/C; 226 M-PCIs, 336 lesions, 68.8% type B2/C). Technical success with R-PCI was 91.7% (rate of manual assistance 11.1%, rate of manual conversion 7.4%, rate of major adverse cardiovascular events 0.93%). Clinical success (99.1% with R-PCI vs. 99.1% with M-PCI; p = 1.00), stent use (stents per procedure 1.59 ± 0.79 with R-PCI vs. 1.54 ± 0.75 with M-PCI; p = 0.73), and fluoroscopy time (18.2 ± 10.4 min with R-PCI vs. 19.2 ± 11.4 min with M-PCI; p = 0.39) were similar between the groups, although procedure time was longer in the R-PCI group (44:30 ± 26:04 min:s vs. 36:34 ± 23:03 min:s; p = 0.002). Propensity-matched analysis confirmed that procedure time was longer

  6. Operation with monosequences in ASEA-ATOM BWR. A way of reducing the impact of PCI

    International Nuclear Information System (INIS)

    Olsson, S.

    1981-01-01

    The energy loss due to PCI restrictions for a start-up after refuelling (or after sequence exchange) is about 18 EFPH (Effective Full Power Hours). All ASEA-ATOM BWRs are equipped with fine motion control rod drives (FMCRD), which makes it possible to withdraw control rods at full power in acceptably small steps (1.8 cm) from the PCI point of view. Thus burnup compensation can always be done without any energy loss due to PCI-restrictions. The ASEA-ATOM PCI-related operating restrictions are described and their implication on the operations of an ASEA-ATOM BWR is discussed. It was shown how the energy generation losses due to PCI-restrictions could be reduced to a minimum, by proper use of continuous motion screw-type control rod drives and high-capacity recirculation pumps, together with advanced use of burnable absorber, and refined refuelling schemes. Monosequence Operation (MSO) has reduced energy generation losses due to PCI-restrictions from about 1% to about 0.4%. MSO has been in routine use in Swedish BWRs since 1977 and during 1980 the fourteenth successful MSO-cycle has been completed

  7. Prokofiev: Cantate pour le 20e anniversaire de la revolution d'Octobre op. 74 / Pierre-E. Barbier

    Index Scriptorium Estoniae

    Barbier, Pierre-E.

    1992-01-01

    Uuest heliplaadist "Prokofiev: Cantate pour le 20e anniversaire de la revolution d'Octobre op. 74. La Fleur de pierre op. 118 (extraits). Gennadi Rojdestvenski, Philharmonia Chorus and Orchestra, Neeme Järvi" CHAN 9095

  8. The effects of tirofiban infusion on clinical and angiographic outcomes of patients with STEMI undergoing primary PCI.

    Science.gov (United States)

    Kaymaz, Cihangir; Keleş, Nurşen; Özdemir, Nihal; Tanboğa, İbrahim Halil; Demircan, Hacer C; Can, Mehmet M; Koca, Fatih; İzgi, İbrahim Akın; Özkan, Alper; Türkmen, Muhsin; Kırma, Cevat; Esen, Ali M

    2015-11-01

    The present study was designed to determine the effects of tirofiban (Tiro) infusion on angiographic measures, ST-segment resolution, and clinical outcomes in patients with STEMI undergoing PCI. Glycoprotein (GP) IIb/IIIa inhibitors are beneficial in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI), while the most effective timing of administration is still under investigation. A total of 1242 patients (83.0% males, mean (standard deviation; SD) age: 54.7 (10.9) years) with STEMI who underwent primary PCI were included in this retrospective non-randomized study in four groups, composed of no tirofiban infusion [Tiro (-); n=248], tirofiban infusion before PCI (pre-Tiro; n=720), tirofiban infusion during PCI (peri-Tiro; n=50), and tirofiban infusion after PCI (post-Tiro; n=224). In all Tiro (+) patients, bolus administration of Tiro (10 µg/kg) was followed by infusion (0.15 µg/kg/min) for a mean (SD) duration of 22.4±6.8 hours. The pre-PCI Tiro group was associated with the highest percentage of patients with TIMI 3 flow (99.4%; p75% ST-segment resolution (78.1%; pPCI significantly improves myocardial reperfusion, ST-segment resolution, in-hospital mortality rate, and in-hospital sudden cardiac death in patients with STEMI with no increased risk of major bleeding.

  9. Appendicite aigue non compliquée: y a-t- il une place pour le traitement conservateur

    Science.gov (United States)

    El Khader, Ahmed; Lahkim, Mohamed; El Barni, Rachid; Achour, Abdessamad

    2015-01-01

    Le but de cette étude a été d’évaluer l'efficacité de l'antibiothérapie seule dans le traitement des appendicites aigues non compliquées. C'est une étude prospective, intéressant 68 patients ayant eu une appendicite aigue simple, de confirmation radiologique, traités par l'amoxicilline associée à l'acide clavulanique pendant 10 jours. L'appendicectomie a été réalisée en cas d'aggravation ou en cas de non amélioration au bout de 48heures de traitement. Le traitement conservateur a été efficace dans 82,35% avec une résolution complète des symptômes chez 56 patients. Les 12 cas restants (17,65%) ont subit une appendicectomie. l'appendicite a été gangréneuse dans 8 cas et phlegmoneuse dans 4 cas. Cinq des 56 patients, qui ont bien évolué sous traitement conservateur, ont été réadmis et opérés pour récidive, soit 8,9%. Deux cas ont eu une appendicite compliquée. L'appendicectomie reste le traitement de référence pour l'appendicite aigue, mais le traitement antibiotique peut être proposé en première intension à des patients présentant une appendicite aigue non compliquée. PMID:26327981

  10. Le boson et le chapeau mexicain un nouveau grand récit de l'univers

    CERN Document Server

    Cohen-Tannoudji, Gilles

    2013-01-01

    Le boson ? C'est l'ultime particule élémentaire prédite par la théorie de l'infiniment petit, qui manquait encore et dont la découverte, grâce au grand collisionneur de hadrons du CERN, a été annoncée au monde entier le 4 juillet 2012. Postulée en 1964 par Robert Brout, François Englert et Peter Higgs, elle explique que le photon - particule qui transmet la force électromagnétique - n'a pas de masse, à l'encontre de celles véhiculant la force faible. Une telle dissymétrie était a priori incompatible avec la symétrie fondamentale, dite «de jauge», sur laquelle est fondé le modèle standard de la physique des particules. Le chapeau mexicain ? C'est le mécanisme grâce auquel le boson rend compte, en préservant les acquis du modèle standard, de l'origine des masses des particules élémentaires. Le boson et le chapeau mexicain se placent à la croisée - retracée par les deux auteurs en dialogue avec François Englert - des chemins de l'évolution des théories de l'astrophysique contemp...

  11. Le contrôle de gestion environnementale d'une entreprise

    OpenAIRE

    Marquet-Pondeville, Sophie

    2001-01-01

    Dans cette recherche, nous étudions comment s’opère le contrôle de gestion environnementale. Cette problématique est abordée dans une perspective contingente et nous proposons un modèle théorique qui met en évidence l’impact de certaines variables sur les systèmes de contrôle de la gestion environnementale. Certains liens présents dans ce modèle sont discutés à travers une étude de cas.

  12. La ballata E5 e le sue varianti nel codice degli abbozzi

    Directory of Open Access Journals (Sweden)

    Giulia Ravera

    2016-07-01

    Full Text Available La ballata petrarchesca Amor, che ’n cielo e ’n cor gentile alberghi (E5, composta per il musico Confortino e destinata alla definitiva esclusione dal Canzoniere, è un componimento profondamente complesso, oltre che caratterizzato da un’intrigante vicenda redazionale. E5 appare infatti imperniata sull’ambiguità tra due poli opposti, amoroso e religioso, in un gioco di contrapposizioni che rende difficile scegliere in via definitiva tra un’interpretazione sentimentale ed una lettura morale o addirittura penitenziale. La ballata è inoltre caratterizzata dall’evidente ed esteso riuso della tradizione lirica ed in particolare dei modelli stilnovistici, non solo e non tanto sul piano degli stilemi e delle immagini, quanto in termini di concezione amorosa. Il rapporto con queste fonti risulta problematico, tra ripresa e negazione, e rappresenta un ulteriore nodo significativo rispetto all’interpretazione del componimento. La graduale evoluzione della ballata, di cui possono essere identificate per lo meno tre versioni distinte, sembra accentuare gli elementi di complessità e le sovrapposizioni semantiche. Infine, l’analisi formale e contenutistica di E5 favorisce la formulazione, pur senza pretesa di certezza, di ipotesi sulle ragioni della sua sorte extravagante

  13. The Factor Structure and Psychometric Properties of the Persian Version of the Revised Prenatal Coping Inventory (Nu-PCI).

    Science.gov (United States)

    Faramarzi, Mahbobeh; Pasha, Hajar; Khafri, Sorayya; Heidary, Shima

    2017-03-01

    Familiarity with coping strategies is essential for stress management during pregnancy. The Revised Prenatal Coping Inventory (Nu-PCI) was developed to assess coping strategies during pregnancy. This study aimed to assess the factor structure and psychometric properties of the Persian version of the Nu-PCI. After forward-backward translation, the Nu-PCI was administered to 210 pregnant women who were enrolled in two teaching referral clinics in the North of the Islamic Republic of Iran (Babol). The participants completed the Persian Nu-PCI and Ways of Coping Questionnaire (WCQ), which was used to determine the validity of the Persian Nu-PCI. To test construct validity of the Persian Nu-PCI, a principal components factor analysis was performed. Principal components analysis with varimax rotation showed a best fitting 3-factor structure similar to the original with three coping subscales: planning-preparation, avoidance, and spiritual-positive coping. The Persian Nu-PCI was internally consistent and within the acceptable range (α=0.89-0.97). The alpha coefficients for the Nu-PCI and the subscales of planning-preparation, avoidance, and spiritual-positive coping were high. Test-retest coefficients for the Nu-PCI and subscales were 0.98-0.99. The Nu-PCI and its subscales correlated with the WCQ in the entire sample and within each trimester. The Persian version of the Nu-PCI and the subscales of planning-preparation, avoidance, and spiritual-positive coping represent the first reliable standardized tool for measuring coping strategies during pregnancy in the Islamic Republic of Iran. Therefore, it can be applied as a quick and accurate preliminary screening tool for evaluating coping strategies throughout pregnancy in clinics and other medical and research settings.

  14. Femoral Access PCI in a Default Radial Center Identifies High-Risk Patients With Poor Outcomes.

    Science.gov (United States)

    Uddin, Muezz; Bundhoo, Shantu; Mitra, Rito; Ossei-Gerning, Nicholas; Morris, Keith; Anderson, Richard; Kinnaird, Tim

    2015-10-01

    Increasingly the trans-radial route (TRR) is preferred over the trans-femoral route (TFR) for PCI. However, even in high volume default TRR centers a cohort of patients undergo TFR PCI. We examined the demographics, procedural characteristics, and outcomes of patients undergoing PCI via the TF. The patient demographics, procedural data, and outcomes of 5,379 consecutive patients undergoing PCI at a default radial center between 2009 and 2012 were examined. Major bleeding (MB) was classified by ACUITY and BARC definitions. A total of 559 (10.4%) patients underwent PCI via the TFR and 4,820 patients via the TRR (89.6%). Baseline variables associated with TFR were shock, previous CABG, chronic total occlusion intervention, rotablation/laser use, female sex, and renal failure. Sixty-five patients of the TFR cohort (11.6%) experienced MB with 27 (41.5%) being access site related. MB was significantly more frequent than in the radial cohort. The variables independently associated with MB in the TFR cohort were renal failure, acute presentation, shock, and age. In the TFR, patients with MB mortality was high at 30 days (17.2% vs 2.6% for no MB, P default radial PCI center 10% of patients undergo PCI via the femoral artery. These patients have high baseline bleeding risk and undergo complex interventions. As a result the incidence of major bleeding, transfusion and death are high. Alternative strategies are required to optimize outcomes in this select group. © 2015, Wiley Periodicals, Inc.

  15. La “morte digitale”, le nuove forme di commemorazione del lutto online e il ripensamento delle idee di morte e d’immortalità

    Directory of Open Access Journals (Sweden)

    Giovanni Ziccardi

    2017-05-01

    Full Text Available SOMMARIO: 1. Premessa: la “morte digitale” - 2. Le piattaforme tecnologiche, il diritto e la gestione degli utenti defunti - 3. La morte “in diretta” e la condivisione online del lutto - 4. Il fenomeno dei selfie funerari - 5. Le cerimonie funebri trasmesse in live streaming - 6. L’evoluzione del lutto: da offline a online - 7. Il ripensamento collettivo in corso - 8. L’immortalità tecnologica - 9. Il problema della “dipendenza” e della “confusione” - 10. Alcune considerazioni conclusive.

  16. Prognostic relevance of PCI-related myocardial infarction

    NARCIS (Netherlands)

    Woudstra, Pier; Grundeken, Maik J.; van de Hoef, Tim P.; Wallentin, Lars; Fox, Keith A.; de Winter, Robbert J.; Damman, Peter

    2013-01-01

    Procedure-related myocardial infarction (pMI) is directly associated with a coronary revascularization procedure, such as percutaneous coronary intervention (PCI) or CABG surgery. In contrast to spontaneous myocardial infarction (MI), the prognostic relevance of pMI is the subject of ongoing debate.

  17. [Effects of PCI-32765 and Dasatinib on the Acute Lymphoblastic Leukemic Cells and Their Mechanisms].

    Science.gov (United States)

    Deng, Yuan; Tao, Shan-Dong; Zhang, Xin; Ma, Jing-Jing; He, Zheng-Mei; Chen, Yue; Deng, Zhi-Kui; Yu, Liang

    2017-02-01

    To investigate the effects of Btk inhibitor (PCI-32765) and BCR-ABL tyrosine kinase inhibitor (Dasatinib) on proliferation and apoptosis of acute lymphoblastic leukemia (ALL) cell lines (Sup-B15, RS4;11) and the possible mechanism. RS4;11 and Sup-B15 cells were treated with PCI-32765 and Dasatinib, the cell proliferation and apoptosis were detected by CCK-8, the Btk and other apoptotic proteins were detected by Western blot. PCI-32765 could inhibit the proliferation of RS4;11 and Sup-B15 cells in a dose-dependent manner, Sup-B15 cells were more sensitive to PCI-32765 than RS4;11 cells, their IC 50 were 3 µmol/L and 8 µmol/L respectively, the difference between them was statistically significant (PPCI-32765(PPCI-32765 or Dasatinib alone group and the combination group at the different time-point (8, 12, 24, 36, 48 and 72 h), the 2 drugs showed a synergistic effect on cells in a time-dependent manner. After being treated with PCI-32765 and Dasatinib, the RS4;11 and Sup-B15 cells showed that cell shrinkage, increase of cytoplasmic density, nuclear pyknosis, deviation and karyorrhexis, and increase of the apoptotic cells in the combination group, while the promotive effect of low dosage dasatinib on apoptosis of RS4;11 cells was not strong. PCI-32765 and Dasatinib could decrease the expression and activity of BCR-ABL, Btk, Lyn, Src in Sup-B15 and RS4;11 cells. PCI-32765 or Dasatinib can inhibit the proliferation and induce the apoptosis of Sup-B15 and RS4;11 cells, PCI-32765 and Dasatinib displayed the synergistic effects. The possible mechanism may be related with the blocking of B cell receptor(BCR) signal pathway, thereby inhibiting the cell proliferation and promoting the cell apoptosis.

  18. Le candomblé au Brésil, ou l'Afrique réinventée

    OpenAIRE

    Capone , Stefania

    2005-01-01

    Le Brésil est historiquement associé à l'idée d'un métissage – culturel et « racial » – qui aurait donné naissance à une société dépourvue de tensions raciales. La « démocratie raciale » brésilienne est ainsi devenue, dans les années 1950, un modèle à suivre pour le reste du monde. Depuis la fin des années 1970, les leaders du mouvement noir brésilien et certains représentants des maisons de culte de candomblé ont commencé à miner en profondeur ce modèle, en mettant en avant un discours « eth...

  19. Remote Ischemic Postconditioning (RIPC) of the Upper Arm Results in Protection from Cardiac Ischemia-Reperfusion Injury Following Primary Percutaneous Coronary Intervention (PCI) for Acute ST-Segment Elevation Myocardial Infarction (STEMI).

    Science.gov (United States)

    Cao, Bangming; Wang, Haipeng; Zhang, Chi; Xia, Ming; Yang, Xiangjun

    2018-02-19

    BACKGROUND The aim of this study was to evaluate the role of remote ischemic postconditioning (RIPC) of the upper arm on protection from cardiac ischemia-reperfusion injury following primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). MATERIAL AND METHODS Eighty patients with STEMI were randomized into two groups: primary PCI (N=44) and primary PCI+RIPC (N=36). RIPC consisted of four cycles of 5 minutes of occlusion and five minutes of reperfusion by cuff inflation and deflation of the upper arm, commencing within one minute of the first PCI balloon dilatation. Peripheral venous blood samples were collected before PCI and at 0.5, 8, 24, 48, and 72 hours after PCI. Levels of creatine kinase-MB (CK-MB), serum creatinine (Cr), nitric oxide (NO), and stromal cell-derived factor-1α (SDF-1α) were measured. The rates of acute kidney injury (AKI) and the estimated glomerular filtration rate (eGFR) were calculated. RESULTS Patients in the primary PCI+RIPC group, compared with the primary PCI group, had significantly lower peak CK-MB concentrations (PPCI in patients with acute STEMI might provide cardiac and renal protection from ischemia-reperfusion injury via the actions of SDF-1α, and NO.

  20. Age is not a bar to PCI: Insights from the long-term outcomes from off-site PCI in a real-world setting.

    Science.gov (United States)

    Gerber, Robert T; Arri, Satpal S; Mohamed, Mohamed O; Dhillon, Gurpreet; Bandali, Alykhan; Harding, Idris; Gifford, Jeremy; Sandler, Belinda; Corbo, Ben; McWilliams, Eric

    2017-08-01

    We sought to analyze the percutaneous coronary intervention (PCI) outcomes of very elderly patients (V. Eld. group, age >80 years) and compare their outcomes to a less elderly cohort (Eld. group, age 75-80 years) traditionally reported in the literature. Limited data exist on peri-procedural and long-term outcomes following PCI in the V. Eld. (age >80 years), with under-representation of this cohort in randomized controlled trials. These patients present with advanced complex coronary disease and multiple comorbidities. All 580 consecutive patients aged ≥75 years (age 80 ± 4.9 years, 57.4% males) undergoing PCI between April 2006 and November 2011 were included. A total of 624 consecutive lesions were identified and analyzed. All V. Eld. patients (n = 253) were subsequently selected, and their outcomes compared to Eld. patients (n = 327). Mean follow-up was 30.8 ± 2.7 months with 98% clinical follow-up achieved. All comparative data are expressed as (V. Eld. vs Eld.) unless otherwise specified. All-cause mortality was significantly higher in the V. Eld. group (11.9% vs 6.1%), although this did not translate into a significant difference in cardiac mortality (6.3% vs 3.7%) or major adverse cardiac and cerebrovascular events (16.2% vs 12.5%). The composite incidence of myocardial infarction (MI), stroke, definite/probable stent thrombosis, and TIMI major bleed was 4.7%, 1.4% 1.9%, and 6.4%, respectively with no significant difference between both cohorts. This study demonstrates an acceptable occurrence of MI, death, repeat intervention, and stent thrombosis in a high-risk group of V. Eld. patients with de novo lesions. Age alone in the absence of other non-cardiac factors should not prohibit a patient from access to PCI. © 2017, Wiley Periodicals, Inc.

  1. PCI DSS: Security Standard and Security in Fact

    OpenAIRE

    M. V. Kuzin

    2011-01-01

    The article focuses on Payment Card Industry Data Security Standard (PCI DSS) requirements and practices, especially it’s issues and disadvantages to achieve the main goal — security of payment cards infrastructure.

  2. Outcomes of PCI in Relation to Procedural Characteristics and Operator Volumes in the United States.

    Science.gov (United States)

    Fanaroff, Alexander C; Zakroysky, Pearl; Dai, David; Wojdyla, Daniel; Sherwood, Matthew W; Roe, Matthew T; Wang, Tracy Y; Peterson, Eric D; Gurm, Hitinder S; Cohen, Mauricio G; Messenger, John C; Rao, Sunil V

    2017-06-20

    Professional guidelines have reduced the recommended minimum number to an average of 50 percutaneous coronary intervention (PCI) procedures performed annually by each operator. Operator volume patterns and associated outcomes since this change are unknown. The authors describe herein PCI operator procedure volumes; characteristics of low-, intermediate-, and high-volume operators; and the relationship between operator volume and clinical outcomes in a large, contemporary, nationwide sample. Using data from the National Cardiovascular Data Registry collected between July 1, 2009, and March 31, 2015, we examined operator annual PCI volume. We divided operators into low- (100 PCIs per year) volume groups, and determined the adjusted association between annual PCI volume and in-hospital outcomes, including mortality. The median annual number of procedures performed per operator was 59; 44% of operators performed PCI procedures per year. Low-volume operators more frequently performed emergency and primary PCI procedures and practiced at hospitals with lower annual PCI volumes. Unadjusted in-hospital mortality was 1.86% for low-volume operators, 1.73% for intermediate-volume operators, and 1.48% for high-volume operators. The adjusted risk of in-hospital mortality was higher for PCI procedures performed by low- and intermediate-volume operators compared with those performed by high-volume operators (adjusted odds ratio: 1.16 for low versus high; adjusted odds ratio: 1.05 for intermediate vs. high volume) as was the risk for new dialysis post PCI. No volume relationship was observed for post-PCI bleeding. Many PCI operators in the United States are performing fewer than the recommended number of PCI procedures annually. Although absolute risk differences are small and may be partially explained by unmeasured differences in case mix between operators, there remains an inverse relationship between PCI operator volume and in-hospital mortality that persisted in risk

  3. Le modèle fédéral dans le sport français, un principe fondateur dépassé ?

    Directory of Open Access Journals (Sweden)

    Béatrice Barbusse

    2009-06-01

    Full Text Available Dans le sport français, le fédéralisme s’est installé comme une évidence institutionnelle dès la fin du 19e siècle et le début du 20e siècle dans un pays qui pourtant ne se pense pas fédéral. En outre, si son apparition est liée à l’émergence du sport comme nouvelle pratique sociale à côté d’autres pratiques physiques plus traditionnelles, il s’est rapidement imposé comme la pierre angulaire de l’ordre sportif français. Près d’un siècle plus tard, son monopole institutionnel est bousculé voire «concurrencé». Ces constats d’ensemble nous amènent à nous interroger sur les raisons pour lesquelles le sport a épousé le modèle fédéral dans un pays non fédéral, mais aussi sur ses limites actuelles. Est-il encore le modèle approprié aux circonstances contemporaines ? A-t-il toujours sa place dans le système de gouvernance du sport ? Ou bien, a contrario, reste-t-il le dernier rempart légitime face aux excès du sport contemporain (dopage, violence, corruptions, déficits… ? À partir d’une approche socio-historique, il s’est agi dans cet article de reconstruire le fil de la généalogie du fédéralisme sportif tout en s’interrogeant sur ses perspectives. Au delà de la question du fédéralisme, c’est bien celle de la gouvernance du sport contemporain qui est posée.

  4. Antiplatelet drug selection in PCI to vein grafts in patients with acute coronary syndrome and adverse clinical outcomes

    DEFF Research Database (Denmark)

    Sirker, Alex; Kwok, Chun Shing; Kontopantelis, Evangelos

    2018-01-01

    OBJECTIVE: This study aims to evaluate outcomes associated with different P2Y12 agents in Saphenous Vein graft (SVG) percutaneous coronary intervention (PCI). BACKGROUND: SVG PCI is associated with greater risks of ischemic complications, compared with native coronary PCI. Outcomes associated...... with the use of potent P2Y12 blocking drugs, Prasugrel and Ticagrelor, in SVG PCI are unknown. METHODS: Patients included in the study underwent SVG PCI in the United Kingdom between 2007 and 2014 for acute coronary syndrome and were grouped by P2Y12 antiplatelet use. In-hospital major adverse cardiac events....... CONCLUSIONS: Our real world national study provides no clear evidence to indicate that use of potent P2Y12 blockers in SVG PCI is associated with improved clinical outcomes....

  5. Changements climatiques et infiltrations d'eau salée le long du ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La Méditerranée orientale est très exposée aux infiltrations d'eau salée dans les aquifères (qui contiennent de l'eau douce) se trouvant sur son littoral. La dégradation des aquifères pourrait entraîner de graves conséquences socioéconomiques pour les personnes qui vivent en ces lieux. Le projet consistera à étudier ...

  6. Rapport financier trimestriel pour le trimestre qui a pris fin le 31

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    31 déc. 2015 ... Le CRDI finance des travaux de recherche appliquée ... recherches pour le développement international (CRDI, le Centre) et ..... voie de développement et sur la mise en oeuvre des connaissances scientifiques, techniques et autres en .... Les accords expirent à des dates différentes, et le dernier prend fin.

  7. Rapport financier trimestriel pour le trimestre qui a pris fin le 30

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    30 sept. 2015 ... Le CRDI finance des travaux de recherche appliquée ... recherches pour le développement international (le Centre) et de ..... voie de développement et sur la mise en oeuvre des connaissances scientifiques, techniques et autres en .... Les accords expirent à des dates différentes, et le dernier prend fin en.

  8. The impact of a 600-mg loading dose of clopidogrel in diabetic and non-diabetic patients undergoing elective PCI.

    Science.gov (United States)

    Mohareb, Mina W; Abd Elghany, Mohamed; Sabry, Nirmeen A; Farid, Samar F

    2016-08-01

    High platelet reactivity (HPR) and suboptimal response to dual antiplatelet therapy (DAPT) may explain high recurrent rates of ischemic events in type 1 and 2 diabetes mellitus (DM) patients undergoing percutaneous coronary intervention (PCI). The aim of this study was to determine the effect of diabetes mellitus on clopidogrel activity in cardiac patients undergoing PCI. This is an observational study. Patients were categorized according to DM status into diabetic group (N.=30) and non-diabetic group (N.=33). All patients received clopidogrel in a loading dose of 600 mg before PCI. Platelet function was assessed using light transmittance aggregometry (LTA) technique at baseline (before clopidogrel administration), 24 hour after clopidogrel loading dose administration and 7-10 days after PCI. All patients were followed up for at least one year after PCI for recurrence of acute cardiac events. There was no statistically significant difference between the two groups with respect to 10 µm adenosine diphosphate (ADP)-induced platelet aggregation measured at baseline (P=0.64), 24 hours after PCI (P=0.874), and 7-10 days after PCI (0.643). Diabetics were not significantly different from non-diabetics in terms of post-PCI acute stent thrombosis (P=0.945), sub-acute stent thrombosis (P=0.945), unstable angina (P=0.29) and cardiac death (P=0.64). There was a statistically significant difference between patients with and without post-PCI acute events regarding ADP aggregation measured 24 hours and 7-10 days after PCI. The use of a high loading dose of clopidogrel (600 mg) in patients undergoing elective PCI can overcome the significant increase in post-PCI platelet aggregation and rate of acute cardiac events induced by diabetes mellitus as co-morbidity in those patients.

  9. Von Krahli teater kolib mõneks ajaks Saksamaale / Rain Tolk

    Index Scriptorium Estoniae

    Tolk, Rain, 1977-

    2006-01-01

    Von Krahli Teatri selle hooaja eelviimane esietendus "Europiraadid" on 17. mail Düsseldorfis, koostöös Saksamaa teatrirühmaga Showcase Beat Le Mot. Eesti poole pealt teevad kaasa Juhan Ulfsak, Taavi Eelmaa, Maarja Jakobson ja üllatusmängijana filmimees Rain Tolk, kes räägib oma suhtumisest teatrisse ja suhetest Von Krahli Teatriga

  10. Le livre sur le livre traité de documentation

    CERN Document Server

    Otlet, Paul

    2015-01-01

    Paul Otlet est considéré comme le père des sciences de l'information. Ouvrage fondateur et fondamental, le Traité de documentation. Le livre sur le livre (1934) est l'aboutissement de son travail inlassable pour rassembler, classer et partager les connaissances. Otlet y propose une remarquable synthèse du savoir sur le livre et le document en même temps qu'il anticipe Internet et l'hypertexte. La réédition du Traité de documentation, 70 ans après la disparition de son auteur, coïncide avec la réouverture du Mundaneum à Mons, où le fabuleux héritage documentaire légué par Paul Otlet et Henri La Fontaine est conservé. « Ici, la table de travail n'est plus chargée d'aucun livre. À leur place se dresse un écran et à portée un téléphone. Là-bas, au loin, dans un édifice immense, sont tous les livres et tous les renseignements. De là, on fait apparaître sur l'écran la page à lire pour connaître la réponse aux questions posées par téléphone. » Préfaces de Benoît Peeters (éc...

  11. PCI DSS: Security Standard and Security in Fact

    Directory of Open Access Journals (Sweden)

    M. V. Kuzin

    2011-12-01

    Full Text Available The article focuses on Payment Card Industry Data Security Standard (PCI DSS requirements and practices, especially it’s issues and disadvantages to achieve the main goal — security of payment cards infrastructure.

  12. L’expression de l’affectivité d’un solitaire : le chauffeur de La Tournée d’automne

    Directory of Open Access Journals (Sweden)

    Liliana Sandu-Goilan

    2007-05-01

    Full Text Available Notre étude se propose d’analyser, en prenant comme exemple le roman « La tournée d’automne » de l’écrivain québécois Jacques Poulin, comment le protagoniste du récit poulinien exprime son affectivité à travers la communication verbale et non verbale. Le Chauffeur, comme tous les autres personnages de son univers romanesque, est un solitaire nomade à la recherche du bonheur et de la chaleur humaine. Il entreprend cette quête à travers les relations sociales (travail, amitié et amour qui le mettent en interaction avec d’autres individus et qui lui demandent des compétences sociales où l’attention portée à l’autre est capitale.

  13. Le jeu de la création : Le mangeur (2005) de Ying Chen

    OpenAIRE

    Nicole Dunham

    2013-01-01

    Le théoricien James Hans définit le jeu comme une déconstruction structurante, un processus de perpétuelle remise en question. Dans Le Mangeur (2005) de Ying Chen, la narratrice revit un épisode d’une de ses vies passées où elle meurt mangée, avalée, par son père, descendant dans le « tunnel » du ventre de ce dernier. Cependant, suite à cet événement, elle se retrouve dans un autre espace-temps où elle rencontre son mari, A.. Une équivalence s’établit dans le roman entre les éléments suivants...

  14. Chi ha paura del relativismo? Peirce, Wittgenstein, Vygotski e le radici linguistiche della conoscenza (non della realtà.

    Directory of Open Access Journals (Sweden)

    Letizia Caronia

    2012-11-01

    Full Text Available Le derive decostruzioniste e antirealiste e la discutibile equivalenza tra relativismo e disimpegno scettico hanno necessariamente prodotto un richiamo al realismo e un ennesimo appello alla necessità di una fondazione ultima delle conoscenze, delle decisioni e delle pratiche. Stiamo gettando via il bambino insieme all’acqua sporca? Questo articolo argomenta la tesi dell’irritante ineluttabilità del costruttivismo. Attraverso un riordinamento delle categorie pertinenti e sulla scorta del pensiero di Peirce, Wittgenstein e Vygotsky, si sostiene che il costruttivismo a presuppone una ontologia realista; b afferma che la realtà sia osservabile, rappresentabile, descrivibile; c implica una definizione di verità come corrispondenza ma nega che sia possibile individuare quell’ “una e una sola” descrizione della realtà che corrisponderebbe alla realtà in modi indipendenti dal linguaggio. Nelle sezioni conclusive si discutono le implicazioni del costruttivismo realista. In particolare ci si propone di dimostrare l’ineludibile e radicale appello alla responsabilità proprio – malgrado le apparenze – di uno dei corollati del costruttivismo: la relatività concettuale e la connessa questione della relatività epistemica.

  15. PCI-24781 can improve in vitro and in vivo developmental capacity of pig somatic cell nuclear transfer embryos.

    Science.gov (United States)

    Jin, Long; Zhu, Hai-Ying; Guo, Qing; Li, Xiao-Chen; Zhang, Yu-Chen; Zhang, Guang-Lei; Xing, Xiao-Xu; Xuan, Mei-Fu; Luo, Qi-Rong; Yin, Xi-Jun; Kang, Jin-Dan

    2016-09-01

    To examine the effect of PCI-24781 (abexinostat) on the blastocyst formation rate in pig somatic cell nuclear transferred (SCNT) embryos and acetylation levels of the histone H3 lysine 9 and histone H4 lysine 12. Treatment with 0.5 nM PCI-24781 for 6 h significantly improved the development of cloned embryos, in comparison to the control group (25.3 vs. 10.5 %, P PCI-24781 treatment led to elevated acetylation of H3K9 and H4K12. TUNEL assay and Hoechst 33342 staining revealed that the percentage of apoptotic cells in blastocysts was significantly lower in PCI-24781-treated SCNT embryos than in untreated embryos. Also, PCI-24781-treated embryos were transferred into three surrogate sows, one of whom became pregnant and two fetuses developed. PCI-24781 improves nuclear reprogramming and the developmental potential of pig SCNT embryos.

  16. Protein C Inhibitor (PCI) Binds to Phosphatidylserine Exposing Cells with Implications in the Phagocytosis of Apoptotic Cells and Activated Platelets

    Science.gov (United States)

    Rieger, Daniela; Assinger, Alice; Einfinger, Katrin; Sokolikova, Barbora; Geiger, Margarethe

    2014-01-01

    Protein C Inhibitor (PCI) is a secreted serine protease inhibitor, belonging to the family of serpins. In addition to activated protein C PCI inactivates several other proteases of the coagulation and fibrinolytic systems, suggesting a regulatory role in hemostasis. Glycosaminoglycans and certain negatively charged phospholipids, like phosphatidylserine, bind to PCI and modulate its activity. Phosphatidylerine (PS) is exposed on the surface of apoptotic cells and known as a phagocytosis marker. We hypothesized that PCI might bind to PS exposed on apoptotic cells and thereby influence their removal by phagocytosis. Using Jurkat T-lymphocytes and U937 myeloid cells, we show here that PCI binds to apoptotic cells to a similar extent at the same sites as Annexin V, but in a different manner as compared to live cells (defined spots on ∼10–30% of cells). PCI dose dependently decreased phagocytosis of apoptotic Jurkat cells by U937 macrophages. Moreover, the phagocytosis of PS exposing, activated platelets by human blood derived monocytes declined in the presence of PCI. In U937 cells the expression of PCI as well as the surface binding of PCI increased with time of phorbol ester treatment/macrophage differentiation. The results of this study suggest a role of PCI not only for the function and/or maturation of macrophages, but also as a negative regulator of apoptotic cell and activated platelets removal. PMID:25000564

  17. Effect of kudiezi injection on stent thrombosis and matrix metalloproteinase in patients with PCI

    International Nuclear Information System (INIS)

    Wang Zhihui; Zhang Jing; Xing Yue

    2010-01-01

    Objective: To investigate the effects of Kudiezi injection on stent thrombosis and the levels of matrix metalloproteinase (MMPs) and thromboxane B 2 (TXB2) in elderly patients with percutaneous coronary intervention (PCI), and investigate the mechanism of Kudiezi on the decrease of stent thrombosis. Methods: Forty elderly patients were divided into two groups (Kudiezi group and control group) after PCI. Kudiezi were administered into patients in Kudiezi group and the patients in control group were treated with regular medication. The angioraphic and clinic follow-up outcomes of 40 elderly patients with PCI there retrospectively analyze. Stent thrombosis (ST) was confirmed by angiography. The levels MMPs and TXB2 in Kudiezi group (n=20) and control group (n=20) were determined before stent implantation and after 6 months. Major cardiac events (restenosis, cardiac death, myocardiac infarction, revasculation) were observed during follow-up. Results: The levels of MMPs and TXB2 in Kudiezi and control group decreased significantly after PCI. The levels of MMPs and TXB2 in Kudiezi group were less than that in control group after PCI. The levels of MMPs and TXB 2 in all patients group were significantly different between pre-procedure and post-procedure (P 2 . (authors)

  18. El periódico en el aula de E/LE

    Directory of Open Access Journals (Sweden)

    Begoña Piedra Lanza

    2012-08-01

    Full Text Available En esta experiencia práctica hacemos uso de un recurso tan económico y accesible como es el periódico para realizar una secuencia de actividades en el aula de Español como Lengua Extranjera (E/LE cuyo objetivo es ejercitar las destrezas de comprensión lectora y de expresión oral de forma integrada.

  19. Scale-space for empty catheter segmentation in PCI fluoroscopic images.

    Science.gov (United States)

    Bacchuwar, Ketan; Cousty, Jean; Vaillant, Régis; Najman, Laurent

    2017-07-01

    In this article, we present a method for empty guiding catheter segmentation in fluoroscopic X-ray images. The guiding catheter, being a commonly visible landmark, its segmentation is an important and a difficult brick for Percutaneous Coronary Intervention (PCI) procedure modeling. In number of clinical situations, the catheter is empty and appears as a low contrasted structure with two parallel and partially disconnected edges. To segment it, we work on the level-set scale-space of image, the min tree, to extract curve blobs. We then propose a novel structural scale-space, a hierarchy built on these curve blobs. The deep connected component, i.e. the cluster of curve blobs on this hierarchy, that maximizes the likelihood to be an empty catheter is retained as final segmentation. We evaluate the performance of the algorithm on a database of 1250 fluoroscopic images from 6 patients. As a result, we obtain very good qualitative and quantitative segmentation performance, with mean precision and recall of 80.48 and 63.04% respectively. We develop a novel structural scale-space to segment a structured object, the empty catheter, in challenging situations where the information content is very sparse in the images. Fully-automatic empty catheter segmentation in X-ray fluoroscopic images is an important and preliminary step in PCI procedure modeling, as it aids in tagging the arrival and removal location of other interventional tools.

  20. pour le trimestre qui a pris fin le 31 décembre 2014

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    31 déc. 2014 ... Le CRDI finance des travaux de recherche appliquée ... recherches pour le développement international (le Centre) et de ...... voie de développement et sur la mise en oeuvre des connaissances scientifiques, techniques et autres en vue .... Les accords expirent à des dates différentes, et le dernier prend fin.

  1. Le déficit de filles

    International Development Research Centre (IDRC) Digital Library (Canada)

    de la population est une tendance plus récente. C. Le déficit de filles. Le déséquilibre du ratio hommes-femmes en Inde. D. R. O. I. T. S. D. E. S. F. E. M. M. E. S. E. T. P. A. R. T. IC. I. P. A. T. IO. N. C. I. T. O. Y. E. N. N. E. CENTRE DE. RECHERCHES. POUR LE. DÉVELOPPEMENT. INTERNATIONAL. CRDI : Jason Taylor ...

  2. Croissance prolongée de la diatomée marine Phaeodactylum tricornutum en milieu contaminé par le chlorure de tributylétain : conséquence sur le biotransfert du polluant

    Directory of Open Access Journals (Sweden)

    MARSOT P.

    1996-04-01

    Full Text Available Cette étude consiste à évaluer le biotransfert du tributylétain (TBT par le filtreur bivalve Mya arenaria, à partir d'une culture semi-continue de la diatomée Phaeodactylum tricornutum exposée à un niveau de contamination n'arrêtant pas sa croissance à long terme. La dose du contaminant employée (100 ng I-1 est de l'ordre de grandeur de celles décelées dans certaines régions contaminées, telles les marinas et les régions portuaires. Dans ces conditions, la culture de P tricornutum a maintenu son équilibre de croissance durant plus de 50 jours. Sa productivité était légèrement inférieure (de 4 % à celle de la culture témoin (sans contaminant. L'ingestion des diatomées contaminées, sur une période de 90 jours, a entraîné une bioaccumulation de TBT et DBT (dibutylétain dans la chair du mollusque, atteignant des concentrations respectives de 133 et 128 ng g-1 (poids humide. L'étude suggère que le biotransfert du TBT et du DBT associés à des micro-algues en croissance continue ou semi-continue pourrait constituer un facteur de bioamplification important du biocide en milieu naturel.

  3. B-type Natriuretic Peptide and RISK-PCI Score in the Risk Assessment in Patients with STEMI Treated by Primary Percutaneous Coronary Intervention.

    Science.gov (United States)

    Asanin, Milika; Mrdovic, Igor; Savic, Lidija; Matic, Dragan; Krljanac, Gordana; Vukcevic, Vladan; Orlic, Dejan; Stankovic, Goran; Marinkovic, Jelena; Stankovic, Sanja

    2016-01-01

    RISK-PCI score is a novel score for risk stratification of patients with ST elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI). The aim of this study was to evaluate the role of B-type natriuretic peptide (BNP) and the RISK-PCI score for early risk assessment in patients with STEMI treated by pPCI. In 120 patients with STEMI treated by pPCI, BNP was measured on admission before pPCI. The primary end point was 30-day mortality. The ROC curve analysis revealed that the most powerful predictive factors of 30-day mortality were the plasma level of BNP ≥ 206.6 pg/mL with the sensitivity of 75% and specificity of 87.5% and the RISK-PCI score ≥ 5.25 with the sensitivity of 75% and specificity of 85.7%. Thirty-day mortality was 6.7%. After multivariate adjustment, admission BNP (≥ 206.6 pg/mL) (OR 2.952, 95% CI 1.072 - 8.133, p = 0.036) and the RISK-PCI score (≥ 5.25) (OR 2.284, 95% CI 1.140-4.578, p = 0.020) were independent predictors of 30-day mortality. The area under the ROC curve using the RISK-PCI score and BNP to detect mortality was 0.828 (p = 0.002) and 0.903 (p PCI score increased the area under the ROC to 0.949 (p PCI score for 30-day mortality. BNP on admission and the RISK-PCI score were the independent predictors of 30-day mortality in patients with the STEMI treated by pPCI. BNP in combination with the RISK-PCI score showed the way to more accurate risk assessment in patients with STEMI treated by pPCI.

  4. Prophylactic Cranial Irradiation (PCI) versus Active MRI Surveillance for Small Cell Lung Cancer: The Case for Equipoise.

    Science.gov (United States)

    Rusthoven, Chad G; Kavanagh, Brian D

    2017-12-01

    Prophylactic cranial irradiation (PCI) for SCLC offers a consistent reduction in the incidence of brain metastases at the cost of measurable toxicity to neurocognitive function and quality of life, in the setting of characteristic pathologic changes to the brain. The sequelae of PCI have historically been justified by the perception of an overall survival advantage specific to SCLC. This rationale has now been challenged by a randomized trial in extensive-stage SCLC demonstrating equivalent progression-free survival and a trend toward improved overall survival with PCI omission in the context of modern magnetic resonance imaging (MRI) staging and surveillance. In this article, we critically examine the randomized trials of PCI in extensive-stage SCLC and discuss their implications on the historical data supporting PCI for limited-stage SCLC from the pre-MRI era. Further, we review the toxicity of moderate doses of radiation to the entire brain that underlie the growing interest in active MRI surveillance and PCI omission. Finally, the evidence supporting prospective investigation of radiosurgery for limited brain metastases in SCLC is reviewed. Overall, our aim is to provide an evidence-based assessment of the debate over PCI versus active MRI surveillance and to highlight the need for contemporary trials evaluating optimal central nervous system management in SCLC. Copyright © 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

  5. Pre-hospital ticagrelor in patients with ST-segment elevation myocardial infarction with long transport time to primary PCI facility.

    Science.gov (United States)

    Lupi, Alessandro; Schaffer, Alon; Lazzero, Maurizio; Tessitori, Massimo; De Martino, Leonardo; Rognoni, Andrea; Bongo, Angelo S; Porto, Italo

    2016-12-01

    Pre-hospital ticagrelor, given less than 1h before coronary intervention (PCI), failed to improve coronary reperfusion in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary PCI. It is unknown whether a longer interval from ticagrelor administration to primary PCI might reveal any improvement of coronary reperfusion. We retrospectively compared 143 patients, pre-treated in spoke centers or ambulance with ticagrelor at least 1.5h before PCI (Pre-treatment Group), with 143 propensity score-matched controls treated with ticagrelor in the hub before primary PCI (Control Group) extracted from RENOVAMI, a large observational Italian registry of more than 1400 STEMI patients enrolled from Jan. 2012 to Oct. 2015 (ClinicalTrials.gov id: NCT01347580). The median time from ticagrelor administration and PCI was 2.08h (95% CI 1.66-2.84) in the Pre-treatment Group and 0.56h (95% CI 0.33-0.76) in the Control Group. TIMI flow grade before primary PCI in the infarct related artery was the primary endpoint. The primary endpoint, baseline TIMI flow grade, was significantly higher in Pre-treatment Group (0.88±1.14 vs 0.53±0.86, P=0.02). However in-hospital mortality, in-hospital stent thrombosis, bleeding rates and other clinical and angiographic outcomes were similar in the two groups. In a real world STEMI network, pre-treatment with ticagrelor in spoke hospitals or in ambulance loading at least 1.5h before primary PCI is safe and might improve pre-PCI coronary reperfusion, in comparison with ticagrelor administration immediately before PCI. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. L'evoluzione della stampa 3D e le sue applicazioni in campo museale

    Directory of Open Access Journals (Sweden)

    Francesco Pignatelli

    2014-07-01

    Full Text Available ItLa stampa 3D è passata dall'uso solo industriale al grande pubblico degli appassionati e dei maker. Questa evoluzione interessa anche i musei, che possono adottare le tecniche di stampa 3D per rendere più fruibili le loro collezioni, creare una maggiore interattività con il pubblico potenziale e generare nuovo business attraverso il merchandising. Più in futuro i musei andranno verso un modello in cui l'originale e la copia ad alta precisione ottenuta con la stampa 3D, e persino il suo modello digitale, avranno ruoli complementari.En3D printing migrated from industrial manufacturing to a much wider audience of small companies and self-producers. This evolution shows interesting implications also for museums: they can adopt 3D printing techniques to make their collections more accessible, develop more interactivity for their visitors and generate new business through a new kind of merchandising. More will change in the future, when the original artwork and its 3D-printed replicas, and even its digital 3D model, will play complementary roles. 

  7. Le projet MP5 Gestion de la maintenance assistée par ordinateur

    CERN Document Server

    Oliger, S

    2001-01-01

    L'année 2000 marque un tournant dans la manière d'appréhender l'activité de maintenance dans la division ST. Les méthodes, jusqu'alors basées sur une approche corporative relayée par des outils informatiques d'ancienne génération, ont évolué vers une approche intégrée. Ce document décrit tous les aspects du projet de migration de l'ancien logiciel RAPIER vers le nouveau logiciel MP5: définition des ressources, identification des contraintes et des facteurs de succès critiques, planification, unification des méthodes et des données, migration informatique, formation du personnel et mise en service. Il présente également les intégrations réalisées avec d'autres logiciels, les possibilités d'évolution pour la division et les perspectives de généralisation pour le CERN.

  8. Il Servizio Nazionale di Valutazione e le prove Invalsi. Stato dell’arte e proposte per una valutazione come agente di cambiamento

    Directory of Open Access Journals (Sweden)

    Roberto Trinchero

    2014-12-01

    Full Text Available Qual è la funzione del Servizio Nazionale di Valutazione formativa degli istituti scolastici? A cosa servono davvero le prove Invalsi? Le critiche che spesso vengono mosse a queste prove sono veramente fondate? Come può la valutazione dell’offerta formativa scolastica costituire davvero un agente di miglioramento? Il presente articolo intende fornire alcune risposte a queste domande, partendo dalle istanze che hanno ispirato l’autonomia scolastica e offrendo spunti per un utilizzo non fazioso della valutazione. La valutazione può essere davvero agente di cambiamento a patto che: i sia attribuito ai dati il corretto significato; ii la scuola sia in grado di comprendere i potenziali suggerimenti che la valutazione può dare e si apra al cambiamento positivo. La valutazione applicata ad una “scuola che si difende” non può che provocare inutili esiti di facciata. La valutazione applicata ad una “scuola che apprende” può davvero aiutarla ad esplicare appieno tutte le proprie potenzialità.

  9. Charcoal injection in blast furnaces (Bio-PCI: CO2 reduction potential and economic prospects

    Directory of Open Access Journals (Sweden)

    Cristobal Feliciano-Bruzual

    2014-07-01

    Full Text Available The steel industry is under pressure to reduce its CO2 emissions, which arise from the use of coal. In the long-term, the injection of pulverized particles of charcoal from biomass through blast furnace tuyeres, in this case called Bio-PCI, is an attractive method from both an environmental and metallurgical viewpoint. The potential of Bio-PCI has been assessed in terms of its CO2 abatement potential and economic viewpoint. A cost objective function has been used to measure the impact of biochar substitution in highly fuel-efficient BF among the top nine hot metal producers; estimations are based on the relevant cost determinants of ironmaking. This contribution aims to shed light on two strategic questions: Under what conditions is the implementation of Bio-PCI economically attractive? Additionally, where is such a techno-economic innovation likely to be taken up the earliest? The results indicate the potential for an 18–40% mitigation of CO2. Findings from the economic assessment show that biochar cannot compete with fossil coal on price alone; therefore, a lower cost of biochar or the introduction of carbon taxes will be necessary to increase the competitiveness of Bio-PCI. Based on the current prices of raw materials, electricity and carbon taxes, biochar should be between 130.1 and 236.4 USD/t and carbon taxes should be between 47.1 and 198.7 USD/t CO2 to facilitate the substitution of Bio-PCI in the examined countries. In regard to implementation, Brazil, followed by India, China and the USA appeared to be in a better position to deploy Bio-PCI.

  10. Implementing the Payment Card Industry (PCI Data Security Standard (DSS

    Directory of Open Access Journals (Sweden)

    John O' Raw

    2011-08-01

    Full Text Available Underpinned by the rise in online criminality, the payment card industry (PCI data security standards (DSS were introduced which outlines a subset of the core principals and requirements that must be followed, including precautions relating to the software that processes credit card data. The necessity to implement these requirements in existing software applications can present software owners and developers with a range of issues. We present here a generic solution to the sensitive issue of PCI compliance where aspect orientated programming (AOP can be applied to meet the requirement of masking the primary account number (PAN. Our architecture allows a definite amount of code to be added which intercepts all the methods specified in the aspect, regardless of future additions to the system thus reducing the amount of work required to the maintain aspect. We believe that the concepts here will provide an insight into how to approach the PCI requirements to undertake the task. The software artefact should also serve as a guide to developers attempting to implement new applications, where security and design are fundamental elements that should be considered through each phase of the software development lifecycle and not as an afterthought.

  11. Delay From First Medical Contact to Primary PCI and All‐Cause Mortality: A Nationwide Study of Patients With ST‐Elevation Myocardial Infarction

    Science.gov (United States)

    Koul, Sasha; Andell, Pontus; Martinsson, Andreas; Gustav Smith, J.; van der Pals, Jesper; Scherstén, Fredrik; Jernberg, Tomas; Lagerqvist, Bo; Erlinge, David

    2014-01-01

    Background Early reperfusion in the setting of an ST‐elevation myocardial infarction (STEMI) is of utmost importance. However, the effects of early versus late reperfusion in this patient group undergoing primary percutaneous coronary intervention (PCI) have so far been inconsistent in previous studies. The purpose of this study was to evaluate in a nationwide cohort the effects of delay from first medical contact to PCI (first medical contact [FMC]‐to‐PCI) and secondarily delay from symptom‐to‐PCI on clinical outcomes. Methods and Results Using the national Swedish Coronary Angiography and Angioplasty Register (SCAAR) registry, STEMI patients undergoing primary PCI between the years 2003 and 2008 were screened for. A total of 13 790 patients were included in the FMC‐to‐PCI analysis and 11 489 patients were included in the symptom‐to‐PCI analyses. Unadjusted as well as multivariable analyses showed an overall significant association between increasing FMC‐to‐PCI delay and 1‐year mortality. A statistically significant increase in mortality was noted at FMC‐to‐PCI delays exceeding 1 hour in an incremental fashion. FMC‐to‐PCI delays in excess of 1 hour were also significantly associated with an increase in severe left ventricular dysfunction at discharge. An overall significant association between increasing symptom‐to‐PCI delays and 1‐year mortality was noted. However, when stratified into time delay cohorts, no symptom‐to‐PCI delay except for the highest time delay showed a statistically significant association with increased mortality. Conclusions Delays in FMC‐to‐PCI were strongly associated with increased mortality already at delays of more than 1 hour, possibly through an increase in severe heart failure. A goal of FMC‐to‐PCI of less than 1 hour might save patient lives. PMID:24595190

  12. Coronary artery ectasia, an independent predictor of no-reflow after primary PCI for ST-elevation myocardial infarction.

    Science.gov (United States)

    Schram, H C F; Hemradj, V V; Hermanides, R S; Kedhi, E; Ottervanger, J P

    2018-04-25

    The no-reflow phenomenon is a serious complication after primary percutaneous coronary intervention (PCI) for ST-elevation Myocardial Infarction (STEMI). Coronary artery ectasia (CAE) may increase the risk of no-reflow, however, only limited data is available on the potential impact of CAE. The aim of this study was to determine the potential association between CAE and no-reflow after primary PCI. A case control study was performed based on a prospective cohort of STEMI patients from January 2000 to December 2011. All patients with TIMI 0-1 flow post primary PCI, in the absence of dissection, thrombus, spasm or high-grade residual stenosis, were considered as no-reflow case. Control subjects were two consecutive STEMI patients after each case, with TIMI flow ≥2 after primary PCI. CAE was defined as dilatation of an arterial segment to a diameter at least 1.5 times that of the adjacent normal coronary artery. In the no-reflow group, frequency of CAE was significantly higher (33.8% vs 3.9%, p PCI (91% vs 71% p = 0.03), less often anterior STEMI (3% vs 37%, p PCI with stenting (47% vs 74%, p = 0.003). After multivariate analysis, CAE remained a strong and independent predictor of no-reflow (OR 13.9, CI 4.7-41.2, p PCI for STEMI. Future studies should assess optimal treatment. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Gossip Girls : lele du potin dans quelques romans pour adolescentes

    Directory of Open Access Journals (Sweden)

    Daniela Di Cecco

    2014-04-01

    Full Text Available Cet article explore lele joué par le potin dans une sélection de romans anglophones publiés aux Etats-Unis et au Canada pour adolescentes et préadolescentes. Des études psychologiques et sociologiques récentes sur les agressions féminines et la façon dont les filles infligent de la peine aux autres filles de façon indirecte et voilée servent de cadre à notre analyse. Le fait que la violence physique soit considérée comme un comportement réservé aux garçons et donc inapproprié pour les filles, incite les adolescentes à agir autrement. Le potin devient parfois une arme pour marginaliser ou punir une fille, mais il peut aussi jouer un rôle positif au niveau de la cohésion d’une bande et de la solidarité entre filles.

  14. I desideri e le masse. Una riflessione sul presente

    Directory of Open Access Journals (Sweden)

    Guido Mazzoni

    2013-08-01

    Full Text Available Negli ultimi quarantacinque anni la vita psichica delle masse occidentali ha subito una metamorfosi senza precedenti; noi tutti ne siamo stati trasformati e travolti. Fedele a un’idea eroica e maschile dell’accadere e dell’esperienza, all’idea che le rotture epocali si manifestino sotto forma di guerre e rivoluzioni, una parte della cultura contemporanea continua a sottovalutare la portata di quanto è avvenuto. È una miopia che si manifesta talvolta in forma esplicita e più spesso in forma implicita, come accade ogni volta che applichiamo alla nostra epoca concetti, parole e miti che non reggono più. Molte delle categorie con cui giudichiamo il presente, con cui prendiamo una posizione etico-politica sui problemi della nostra epoca, danno l’impressione di scivolare sulla realtà senza afferrarla, o perché fanno riferimento a un futuro che, non rimandando più a un progetto politico, rappresenta solo la proiezione di un desiderio, o perché fanno riferimento a un passato che non ritornerà. Quali sono i tratti più vistosi della metamorfosi? Che cosa è accaduto?

  15. Le corps dans l’espace architectural. Le Corbusier, Claude Parent et Henri Gaudin

    Directory of Open Access Journals (Sweden)

    Julie Cattant

    2016-12-01

    Full Text Available Le premier geste de l’espace architectural est d’accueillir nos corps humains. En leur offrant un espacement à habiter, il leur permet de s’abriter, de se mouvoir et de se rencontrer. L’homme et l’architecture s’affectent l’un l’autre. Nombreux sont les architectes qui interrogent cette coexistence car, renouveler la pensée de l’espace nécessite de reconsidérer le corps humain. L’étude des relations entre le corps et l’espace chez trois architectes français sera l’occasion d’évoquer les écarts et les convergences entre l’homme et l’architecture. L’œuvre de Le Corbusier, protagoniste du mouvement moderne, maintient ainsi une distance entre un corps machinisé et un espace idéal. Marquée par un mode de pensée dualiste, l’architecture de Le Corbusier annonce toutefois son propre dépassement, dépassement que Claude Parent et Henri Gaudin opèreront par la suite à leur manière, le premier en introduisant l’oblique et la déstabilisation du corps, le second en transgressant la limite de l’espace et du corps pour envisager leur porosité réciproque. Finalement, c’est la manière dont l’homme appréhende l’espace avec son corps qui est questionnée par ces trois architectes, de la prégnance du visuel à son évincement.

  16. Description of a Heart Team approach to coronary revascularization and its beneficial long-term effect on clinical events after PCI.

    Science.gov (United States)

    Bonzel, Tassilo; Schächinger, Volker; Dörge, Hilmar

    2016-05-01

    We present a first description of a Heart Team (HT)-guided approach to coronary revascularization and its long-term effect on clinical events after percutaneous coronary intervention (PCI). The HT approach is a structured process to decide for coronary bypass grafting (CABG), PCI or conservative therapy in ad hoc situations as well as in HT conferences. As a hypothesis, during the long-term course after a PCI performed according to HT rules, a low number of late revascularizations, especially CABGs, are expected (F-PCI study). In this monocentric study, the HT approach to an all-comer population was first analyzed and described in general with the help of a database. Next the use of a HT approach was described for a more homogeneous subgroup with newly detected CAD (1.CAD). Those patients in whom the HT decision was PCI (which was a 1.PCI) were then studied with the help of questionnaires for clinical events during a very long-term follow-up. Events were CABG, PCI, diagnostic catheterization (DCath) and death. A significant number of patients were presented to HT conferences: 22 % out of all 11,174 catheterizations, 24 % out of all 7867 CAD cases and 35 % out of 3408 1.CAD cases. Most of these patients had multi-vessel disease (MVD). Conference decisions were isolated CABG in 46-66 %, PCI in 10-14 %, valvular surgery in 9-16 %, HTx in 10-21 % (Endstage heart failure candidates for surgery) and conservative therapy (Medical or no therapy, additional diagnostic procedures or no adherence to recommended therapy) in 2-3 %. However, most PCIs, ad hoc and elective, were performed under Heart Team rules, but without conference. During follow-up of 1.PCI patients (Kaplan-Meier analysis), CABG occurred in only 15 % of patients, PCI in 37 % and DCath in 65 %; mortality of any course was 51 %. Mortalities were similar in one-vessel disease and in a population of the same year, matched for age and sex (p PCI patients with MVD (p PCI) rates after a 1.PCI, without

  17. A PWR PCI failure criterion to burnups of 60 GW·d/t using the ENIGMA code

    International Nuclear Information System (INIS)

    Clarke, A.P.; Tempest, P.A.; Shea, J.H.

    2000-01-01

    A fuel performance modelling code (ENIGMA) has been used to analyse the empirical PCI failure criterion in terms of a clad failure stress as a function of burnup and fast neutron dose. The Studsvik database has been analysed. Results indicate a rising and then saturating failure stress with burnup and fast neutron dose. Using the PCI failure limits, equivalent to 95/95 confidence limits, an ENIGMA stress-based methodology is used to derive PWR PCI failure limits up to 60 GW·d/t U using a conservative assumption that the failure stress does not increase at high burnup and neutron dose. In addition experimental ramp data on gadolinia-doped fuel rods do not indicate any increased susceptibility to PCI failure implying that the UO 2 criterion can be used for gadolinia doped fuel. (author)

  18. Le fabbricerie, esempio di intesa tra autorità civile e autorità religiosa

    Directory of Open Access Journals (Sweden)

    Paolo Moneta

    2017-11-01

    Full Text Available SOMMARIO: 1. Crescente attenzione verso le fabbricerie e il loro organo di amministrazione - 2. Una recente sentenza del TAR Toscana sul consiglio di amministrazione delle fabbricerie - 3. La posizione del vescovo diocesano nei riguardi delle fabbricerie.

  19. Editorial L&E, v.8, n.3, 2014

    Directory of Open Access Journals (Sweden)

    Rede Conpadre

    2014-09-01

    Full Text Available Editorial L&E, v.8, n.3, 2014. É sempre uma satisfação apresentar mais um número da Revista Labor & Engenho [ISSN:2176-8846]. Neste, o leitor poderá apreciar 7 excelentes artigos que juntos refletem diferentes aspectos das benéficas conexões que se estabelecem entre Patrimônio e Desenvolvimento Regional. Dos 7 artigos que compõem o número 3 do volume 8 da Revista L&E, 3 são de autores brasileiros (sendo 2 no idioma português, 1 em inglês; 2 são de autores argentinos (em espanhol; 1 de autores cubanos (também em espanhol; e 1 de autor francês (publicado no idioma original. Neste número temos, pois, a satisfação de publicar, pela primeira vez na Revista L&E, um artigo proveniente de Cuba e outro da França. Damo-lhes as boas vindas e esperamos por novos artigos originários de países do Caribe ou da América Central, assim como esperamos atrair novos pesquisadores e leitores francófonos, já que o idioma francês era o único dentre os 5 idiomas da Revista L&E que ainda não havia sido publicado neste Periódico. Este número se inicia com o artigo de Gercinair Silvério Gandara, que convida a uma deliciosa visita às águas doces do lago de Sobradinho, no rio São Francisco, onde dormita o patrimônio construído das cidades-beira de Remanso e Pilão Arcado. O trabalho faz parte de sua mais recente pesquisa de Pós-Doutorado, financiada pela CAPES. A autora salienta que a força geradora sociocultural das cidades-beira e sua sinergia com o espaço geográfico ressaltam a importância do Patrimônio Ambiental. Em seguida apresenta-se um artigo sobre as frentes pioneiras do Brasil, enfocando a Amazônia. Não poderia ser mais simbólico e significativo o artigo de Hervé Théry, o primeiro publicado em francês pela Revista Labor & Engenho. Nele o autor, titular da Cátedra Pierre Monbeig (que leva o nome do geógrafo francês que participou da fundação da USP, revisita um de seus trabalhos que seguiram a orientação do pr

  20. La fine delle certezze il tempo, il caos e le leggi della natura

    CERN Document Server

    Prigogine, Ilya

    1997-01-01

    Quella che Prigogine ci indica in questo libro è una stretta via tra un mondo deterministico governato da leggi ferree e un mondo assurdo in preda all'arbitrio del caso: le leggi della fisica assumono un senso nuovo, esprimendo ormai solo delle probabilità. In questa nuova visione del mondo c'è posto per la creatività della natura e dell'uomo.

  1. Time-recovering PCI-AER interface for bio-inspired spiking systems

    Science.gov (United States)

    Paz-Vicente, R.; Linares-Barranco, A.; Cascado, D.; Vicente, S.; Jimenez, G.; Civit, A.

    2005-06-01

    Address Event Representation (AER) is an emergent neuromorphic interchip communication protocol that allows for real-time virtual massive connectivity between huge number neurons located on different chips. By exploiting high speed digital communication circuits (with nano-seconds timings), synaptic neural connections can be time multiplexed, while neural activity signals (with mili-seconds timings) are sampled at low frequencies. Also, neurons generate 'events' according to their activity levels. More active neurons generate more events per unit time, and access the interchip communication channel more frequently, while neurons with low activity consume less communication bandwidth. When building multi-chip muti-layered AER systems it is absolutely necessary to have a computer interface that allows (a) to read AER interchip traffic into the computer and visualize it on screen, and (b) inject a sequence of events at some point of the AER structure. This is necessary for testing and debugging complex AER systems. This paper presents a PCI to AER interface, that dispatches a sequence of events received from the PCI bus with embedded timing information to establish when each event will be delivered. A set of specialized states machines has been introduced to recovery the possible time delays introduced by the asynchronous AER bus. On the input channel, the interface capture events assigning a timestamp and delivers them through the PCI bus to MATLAB applications. It has been implemented in real time hardware using VHDL and it has been tested in a PCI-AER board, developed by authors, that includes a Spartan II 200 FPGA. The demonstration hardware is currently capable to send and receive events at a peak rate of 8,3 Mev/sec, and a typical rate of 1 Mev/sec.

  2. Effect of rosuvastatin intensification therapy on blood lipid metabolism, adipocytokines and plaque stability after PCI in ACS patients

    Directory of Open Access Journals (Sweden)

    Xiu-Quan Sun

    2017-10-01

    Full Text Available Objective: To explore the effect of rosuvastatin intensification therapy on blood lipid metabolism, adipocytokines and plaque stability after PCI in ACS patients. Methods: ACS patients who received PCI in the hospital between July 2015 and January 2017were reviewed and divided into the routine dose group (n=60 who received rosuvastatin routine dose therapy after PCI and the intensification therapy group (n=46 who received rosuvastatin intensification therapy after PCI. The differences in blood lipid metabolism, adipocytokines and plaque stability were compared between the two groups before and after treatment. Results: Before PCI, the differences in blood lipid metabolism, adipocytokines and plaque stability were not statistically significant between the two groups. 1 month after PCI, lipid metabolism indexes HDL-C and ApoA1 levels in peripheral blood of intensification therapy group were higher than those of routine dose group while LDL-C and ApoB levels were lower than those of routine dose group; adipocytokines APN and Leptin levels in serum were higher than those of routine dose group while Resistin level was lower than that of routine dose group; plaque stability- related indexes ICAM-1, MMP-1 and TIMP-1 levels were lower than those of routine dose group. Conclusion: Rosuvastatin intensification therapy after PCI could effectively regulate the lipid metabolism and increase the plaque stability in ACS patients.

  3. The clinical effect of nicorandil on perioperative myocardial protection in patients undergoing elective PCI: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Ye, Ziliang; Su, Qiang; Li, Lang

    2017-03-21

    Many scholars have studied the effect of nicorandil on perioperative myocardial protection in patients undergoing elective percutaneous coronary intervention (PCI), but results are inconsistent. Therefore, we performed this meta-analysis. Finally, 16 articles, including 1616 patients, were included into this meta-analysis. Meta-analysis results showed that: (1) Nicorandil can reduce the level of CK-MB after PCI, including at 6 hours, 12 hours, 18 hours and 24 hours. (2) Nicorandil can reduce the level of TnT after PCI, including at 6 hours, 12 hours, 18 hours and 24 hours. (3) Nicorandil can reduce the incidence of adverse reactions after PCI. (4) Nicorandil cannot reduce the level of MVP after PCI, including at 12 hours and 24 hours. (5) Subgroup analysis showed that nicorandil can reduce CK-MB and TnT level at 24 hours after PCI for Chinese's population (P PCI for non Chinese's population (P > 0.05). Our meta-analysis indicate that nicorandil can reduce myocardial injury and reduce the incidence of adverse reaction caused by PCI for Chinese's population, but is not obvious for non Chinese's population. However, this conclusion still needs to be confirmed in the future.

  4. Narrare la guerra: da Vita e destino a Le Benevole

    Directory of Open Access Journals (Sweden)

    Camilla Panichi

    2014-05-01

    Full Text Available Questo saggio si concentra su due romanzi storici che hanno per argomento la Seconda guerra mon- diale e lo sterminio degli ebrei d’Europa: Vita e destino di Vasilij Grossman (1980 e Le Benevole di Jonathan Littell (2006. La scelta è determinata sia dal rapporto esistente tra i due romanzi, sia dalla convinzione che essi rappresentino, per forma e contenuti, due diversi paradigmi attraverso i quali l’immaginario collettivo ha costruito la narrazione dell’evento guerra. Inoltre si tratta di opere che hanno, in tempi diversi, creato un caso letterario: Le Benevole ha sollevato molti problemi orientando il dibattito su temi etici piuttosto che estetici; Vita e destino ha subito la censura in Unione Sovietica. In questa sede si è scelto di analizzare i romanzi da una prospettiva strettamente letteraria, attraverso due argomenti: la legittimità della costruzione finzionale in rapporto al punto di vista dell’autore (testimone dei fatti narrati nel caso di Grossman, post-testimone nel caso di Littell e l’analisi degli elementi romanzeschi di tradizione ottocentesca e modernista. This paper focuses on two novels narrating the Second World War and the extermination of the Jews of Europe: Life and Fate, by Vasily Grossman (1980, and The Kindly Ones by Jonathan Littell (2006. These books have been chosen because they are closely related to each other and because they embody two different paradigms through which the Second World War has been represented. Moreover both Life and Fate and The Kindly Ones have been literary events: the first was censored in the Soviet Union, the second gave rise to a wide-ranging debate on ethical and aesthetical problems. The following paper analyzes these novels from a strictly literary perspective, focusing on two issues: the legitimacy of fiction (Grossman narrates the war from the standpoint of a witness, Littell, born in 1967, is in the position of the historian and the relationship of these texts with the

  5. Excess mortality in women compared to men after PCI in STEMI: an analysis of 11,931 patients during 2000-2009.

    Science.gov (United States)

    de Boer, Sanneke P M; Roos-Hesselink, Jolien W; van Leeuwen, Maarten A H; Lenzen, Mattie J; van Geuns, Robert-Jan; Regar, Evelyn; van Mieghem, Nicolas M; van Domburg, Ron; Zijlstra, Felix; Serruys, Patrick W; Boersma, Eric

    2014-09-20

    Ambiguity exists whether gender affects outcome in patients undergoing percutaneous coronary intervention (PCI). To evaluate the relationship between gender and outcome in a large cohort of PCI patients, 11,931 consecutive patients who underwent PCI for various indications during 2000-2009 were studied using survival analyses and Cox regression models. Most patients (n=8588; 72%) were men. Women were older and more often had a history of hypertension and diabetes mellitus. Men smoked more frequently, had a more extensive cardiovascular history (previous MI, PCI and CABG), a higher prevalence of renal impairment and multi-vessel disease. In STEMI patients, women had higher 31-day mortality rates than men (11.6% vs. 6.5%, respectively, pPCI for STEMI had higher mortality than men. The excess mortality in women appeared in the first month after PCI and could only partially be explained by a difference in baseline characteristics. No gender differences in outcome in patients undergoing PCI for NSTE-ACS and stable angina were observed. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  6. Prospettive educative per generare e ri-generare le rappresentazioni di genere. Riflessioni da una ricerca.

    Directory of Open Access Journals (Sweden)

    Stefano Benini

    2012-06-01

    Full Text Available Lo scritto segue gli esiti di una ricerca qualitativa “rappresentazione di genere” su  172 adolescenti di Bologna e Rimini.  I dati raccolti sono letti da un punto di vista pedagogico al fine di delineare tracce e metodi per facilitare le ragazze e i ragazzi alla scoperta di sé e a progettarsi nel proprio essere e divenire femmine e maschi.

  7. Computational Fluid Dynamics (CFD) Modeling for High Rate Pulverized Coal Injection (PCI) to Blast Furnaces

    International Nuclear Information System (INIS)

    Zhou, Chenn

    2008-01-01

    Pulverized coal injection (PCI) into the blast furnace (BF) has been recognized as an effective way to decrease the coke and total energy consumption along with minimization of environmental impacts. However, increasing the amount of coal injected into the BF is currently limited by the lack of knowledge of some issues related to the process. It is therefore important to understand the complex physical and chemical phenomena in the PCI process. Due to the difficulty in attaining trus BF measurements, Computational fluid dynamics (CFD) modeling has been identified as a useful technology to provide such knowledge. CFD simulation is powerful for providing detailed information on flow properties and performing parametric studies for process design and optimization. In this project, comprehensive 3-D CFD models have been developed to simulate the PCI process under actual furnace conditions. These models provide raceway size and flow property distributions. The results have provided guidance for optimizing the PCI process

  8. À propos du lexique juridique en ancien français avant le 13e siècle : la Règle de saint Benoît et le Perceval de Chrétien de Troyes

    Directory of Open Access Journals (Sweden)

    Schauwecker Yela

    2012-07-01

    Full Text Available La plus ancienne traduction de la {em Règle} de saint Benoît en franc{c}ais, rédigée en dialecte picard-wallon, date de la première moitié ou du milieu du {sc xii}$^{m e}$~siècle. On veut montrer que son auteur, pour qui le changement de langue, n'est pas le premier objectif s'efforce de transférer le texte de son milieu originel de l'Antiquité tardive dans le monde chevaleresque-féodal du {sc xii}$^{m e}$~siècle. Même sans nécessité apparente, quand il a eu à sa disposition l'équivalent du mot employé dans la {em Regula}, il substitue aux mots latins des termes juridiques et féodaux franc{c}ais. par Son texte, en tant que document de droit pour les moines, devient ainsi une source de vocabulaire juridique franc{c}ais avant le {sc xiii}$^{m e}$~siècle, c'est-à-dire dans un temps où les documents juridiques en langue vulgaire sont extrêmement rares. Cela est dû au fait que la justice, dans le Nord, fondée sur des coutumes, utilisait la langue vernaculaire à l'oral. La terminologie juridique franc{c}aise est bien enracinée dans la langue courante de l'époque~: leur insertion dans les Lais et les Chansons de geste en fait preuve. Mais cette terminologie est souvent méconnue par la lexicographie traditionnelle de l'ancien franc{c}ais, en raison des contextes littéraires et figurés. par

  9. Causes of Death Following PCI Versus CABG in Complex CAD: 5-Year Follow-Up of SYNTAX.

    Science.gov (United States)

    Milojevic, Milan; Head, Stuart J; Parasca, Catalina A; Serruys, Patrick W; Mohr, Friedrich W; Morice, Marie-Claude; Mack, Michael J; Ståhle, Elisabeth; Feldman, Ted E; Dawkins, Keith D; Colombo, Antonio; Kappetein, A Pieter; Holmes, David R

    2016-01-05

    There are no data available on specific causes of death from randomized trials that have compared coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI). The purpose of this study was to investigate specific causes of death, and its predictors, after revascularization for complex coronary disease in patients. An independent Clinical Events Committee consisting of expert physicians who were blinded to the study treatment subclassified causes of death as cardiovascular (cardiac and vascular), noncardiovascular, or undetermined according to the trial protocol. Cardiac deaths were classified as sudden cardiac, related to myocardial infarction (MI), and other cardiac deaths. In the randomized cohort, there were 97 deaths after CABG and 123 deaths after PCI during a 5-year follow-up. After CABG, 49.4% of deaths were cardiovascular, with the greatest cause being heart failure, arrhythmia, or other causes (24.6%), whereas after PCI, the majority of deaths were cardiovascular (67.5%) and as a result of MI (29.3%). The cumulative incidence rates of all-cause death were not significantly different between CABG and PCI (11.4% vs. 13.9%, respectively; p = 0.10), whereas there were significant differences in terms of cardiovascular (5.8% vs. 9.6%, respectively; p = 0.008) and cardiac death (5.3% vs. 9.0%, respectively; p = 0.003), which were caused primarily by a reduction in MI-related death with CABG compared with PCI (0.4% vs. 4.1%, respectively; p PCI versus CABG was an independent predictor of cardiac death (hazard ratio: 1.55; 95% confidence interval: 1.09 to 2.33; p = 0.045). The difference in MI-related death was seen largely in patients with diabetes, 3-vessel disease, or high SYNTAX (TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries) trial scores. During a 5-year follow-up, CABG in comparison with PCI was associated with a significantly reduced rate of MI-related death, which was the

  10. Mortality in patients with TIMI 3 flow after PCI in relation to time delay to reperfusion.

    Science.gov (United States)

    Vichova, Teodora; Maly, Marek; Ulman, Jaroslav; Motovska, Zuzana

    2016-03-01

    Percutaneous coronary intervention (PCI) performed within 12 h from symptom onset enables complete blood flow restoration in infarct-related artery in 90% of patients. Nevertheless, even with complete restoration of epicardial blood flow in culprit vessel (postprocedural Thrombolysis in Myocardial Infarction (TIMI) flow grade 3), myocardial perfusion at tissue level may be insufficient. We hypothesized that the outcome of patients with STEMI/bundle branch block (BBB)-myocardial infarction and post-PCI TIMI 3 flow is related to the time to reperfusion. Observational study based on a retrospective analysis of population of 635 consecutive patients with STEMI/BBB-MI and post-PCI TIMI 3 flow from January 2009 to December 2011 (mean age 63 years, 69.6% males). Mortality of patients was evaluated in relation to the time from symptom onset to reperfusion. A total of 83 patients (13.07%) with postprocedural TIMI 3 flow after PCI had died at 1-year follow-up. Median TD in patients who survived was 3.92 h (iqr 5.43), in patients who died 6.0 h (iqr 11.42), P = 0.004. Multiple logistic regression analysis identified time delay ≥ 9 h as significantly related to 1-year mortality of patients with STEMI/BBB-MI and post-PCI TIMI 3 flow (OR 1.958, P = 0.026). Other significant variables associated with mortality in multivariate regression analysis were: left ventricle ejection fraction 65 years (P 2 (P PCI.

  11. The driving and controlling techniques of compactPCI bus in VxWorks real-time operating system

    International Nuclear Information System (INIS)

    Li Anzong; Ju Xiaodong; Qiao Wenxiao

    2005-01-01

    CompactPCI bus and interface featuring, the content and function of PCI configuration register are introduced herein. The driving and controlling techniques of CompactPCI bus in VxWorks real-time operating system are detailed. Hardware interrupt handling is one of key significance in real-time systems, because it is usually through interrupts that the system is informed of external events. VxWorks allows C functions to be connected to any interrupt. A routine connected to an interrupt in this way is called an interrupt service routine (ISR). For response of interrupt, interrupt control/status register of PCI 9054 interface chip needs to be set. The general-purpose binary semaphore used in ISR is capable of addressing the requirements of both forms of task coordination: mutual exclusion and synchronization. Therefore, the system runs stably and reliably. (authors)

  12. Antithrombotic therapy in patients with non-valvular atrial fibrillation undergoing percutaneous coronary intervention: should we change our practice after the PIONEER AF-PCI and RE-DUAL PCI trials?

    Science.gov (United States)

    Duerschmied, D; Brachmann, J; Darius, H; Frey, N; Katus, H A; Rottbauer, W; Schäfer, A; Thiele, H; Bode, C; Zeymer, Uwe

    2018-04-20

    The number of patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) is increasing. Since these patients have a CHA 2 DS 2 -VASc score of 1 or higher, they should be treated with oral anticoagulation to prevent stroke. However, combination therapy with oral anticoagulation for prevention of embolic stroke and dual platelet inhibition for prevention of coronary thrombosis significantly increases bleeding complications. The optimal combination, intensity and duration of antithrombotic combination therapy is still not known. In the rather small randomized WOEST trial, the combination of a vitamin K antagonist (VKA) and clopidogrel decreased bleeding compared to the conventional triple therapy with VKA, clopidogrel and aspirin. In the PIONEER AF-PCI trial, two rivaroxaban-based treatment regimens significantly reduced bleeding complications compared to conventional triple therapy without increasing embolic or ischemic complications following PCI. Dual therapy with rivaroxaban and clopidogrel appeared to provide an optimal risk-benefit ratio. In the RE-DUAL PCI trial, dual therapy with dabigatran also reduced bleeding complications compared to conventional triple therapy. With respect to the composite efficacy end point of thromboembolic events (myocardial infarction, stroke, or systemic embolism), death, or unplanned revascularization dabigatran-based dual therapy was non-inferior to VKA-based triple therapy. The upcoming trials AUGUSTUS with apixaban and ENTRUST-PCI with edoxaban will further examine the use of NOACs in this setting. While recent guidelines recommend NOAC-based dual therapy in only a subset of patients (those who are at increased risk of bleeding), the available data now suggest that this should be the preferred choice for the majority of patients. Adding aspirin to this primary choice for up to 4 weeks in patients at especially high ischemic risk would likely prevent atherothrombotic events, but this needs further

  13. Le minoranze islamiche nella Bulgaria post-comunista: ingerenze statali e libertà confessionale

    Directory of Open Access Journals (Sweden)

    Paola Fantelli

    2011-03-01

    Full Text Available Contributo segnalato dal Prof. Paolo Moneta, ordinario di Diritto ecclesiastico nella facoltà di Giurisprudenza dell’’Università di Pisa SOMMARIO: 1. Profili istituzionali delle relazioni tra Stato e confessioni religiose nella Bulgaria post-comunista: la posizione dell’Islam. 2. Le ingerenze del Governo bulgaro nell’organizzazione interna delle rappresentanze islamiche secondo la Corte di Strasburgo. 3. Alcune osservazioni sull’ingresso della Bulgaria nell’U.E. e sulle problematiche dell’Islam bulgaro – balcanico.

  14. A risk prediction score model for predicting occurrence of post-PCI vasovagal reflex syndrome: a single center study in Chinese population.

    Science.gov (United States)

    Li, Hai-Yan; Guo, Yu-Tao; Tian, Cui; Song, Chao-Qun; Mu, Yang; Li, Yang; Chen, Yun-Dai

    2017-08-01

    The vasovagal reflex syndrome (VVRS) is common in the patients undergoing percutaneous coronary intervention (PCI). However, prediction and prevention of the risk for the VVRS have not been completely fulfilled. This study was conducted to develop a Risk Prediction Score Model to identify the determinants of VVRS in a large Chinese population cohort receiving PCI. From the hospital electronic medical database, we identified 3550 patients who received PCI (78.0% males, mean age 60 years) in Chinese PLA General Hospital from January 1, 2000 to August 30, 2016. The multivariate analysis and receiver operating characteristic (ROC) analysis were performed. The adverse events of VVRS in the patients were significantly increased after PCI procedure than before the operation (all P PCI was 4.5% (4.1%-5.6%). Compared to the patients suffering no VVRS, incidence of VVRS involved the following factors, namely female gender, primary PCI, hypertension, over two stents implantation in the left anterior descending (LAD), and the femoral puncture site. The multivariate analysis suggested that they were independent risk factors for predicting the incidence of VVRS (all P PCI (c-statistic 0.76, 95% CI: 0.72-0.79, P PCI whose diastolic blood pressure dropped by more than 30 mmHg and heart rate reduced by 10 times per minute (AUC: 0.84, 95% CI: 0.81-0.87, P PCI. In which, the following factors may be involved, the femoral puncture site, female gender, hypertension, primary PCI, and over 2 stents implanted in LAD.

  15. Immediate multivessel percutaneous coronary intervention versus culprit lesion intervention in patients with acute myocardial infarction complicated by cardiogenic shock: results of the ALKK-PCI registry.

    Science.gov (United States)

    Zeymer, Uwe; Hochadel, Mathias; Thiele, Holger; Andresen, Dietrich; Schühlen, Helmut; Brachmann, Johannes; Elsässer, Albrecht; Gitt, Anselm; Zahn, Ralf

    2015-07-01

    Current guidelines recommend immediate multivessel percutaneous coronary intervention (PCI) in patients with cardiogenic shock, despite the lack of randomised trials. We sought to investigate the use and impact on outcome of multivessel PCI in current practice in cardiogenic shock in Germany. Between January 2008 and December 2011 a total of 735 consecutive patients with acute myocardial infarction, cardiogenic shock and multivessel coronary artery disease underwent immediate PCI in 41 hospitals in Germany. Of these, 173 (23.5%) patients were treated with immediate multivessel PCI. The acute success of PCI with respect to TIMI 3 flow did not differ between the groups (82.5% versus 79.6%). In-hospital mortality with multivessel PCI and culprit lesion PCI was 46.8% and 35.8%, respectively. In multivariate analysis multivessel PCI was associated with an increased mortality (odds ratio 1.5; 95% confidence interval 1.15-1.84). In current clinical practice in Germany multivessel PCI is used only in one quarter of patients with cardiogenic shock treated with primary PCI. We observed an adverse effect of immediate multivessel PCI. Therefore, a randomised trial is needed to determine the definitive role of multivessel PCI in cardiogenic shock.

  16. Small cell lung cancer and prophylactic cranial irradiation (PCI): perhaps the question is not who needs PCI but who wants PCI

    Energy Technology Data Exchange (ETDEWEB)

    Le Chevalier, T.; Arriagada, R. [Institut Gustave-Roussy, Medicine Dept., Villejuif, 94 (France)

    1997-10-01

    With 175 000 new cases annually, lung cancer is the most frequent malignancy in adults in the European Community. Approximately 20% of these tumours are of the small cell subtype and roughly a third, chiefly when disease is confined to the thorax, will be in complete remission after aggressive induction therapy combining multidrug chemotherapy (CT) and thoracic radiation therapy. However, the majority of these patients will relapse and ultimately only 15-20% of complete responders will be long-term survivors (i.e. alive beyond 30 months). The central nervous system (CNS) is one of the main organs invaded by small cell lung cancer (SCLC) and a frequent site of relapse. CNS metastases are found in up to 65% of patients at autopsy with the brain traditionally being considered a sanctuary for tumour cells. Although the blood-brain barrier is supposed to bar the entry to harmful substances (in particular most cytotoxic agents) and thus protect the CNS, this shield does not function systematically since dramatic responses to CT have been achieved in brain metastases from SCLC and brain metastases also arise even when clear responses are being observed at all other sites. Alternatively, the spectacular radiosensitivity of SCLC, which has been well established for decades, prompted the strategy of delivering prophylactic cranial irradiation (PCI) during induction treatment in order to prevent the development of metastases and their cohort of clinical symptoms. (author).

  17. Small cell lung cancer and prophylactic cranial irradiation (PCI): perhaps the question is not who needs PCI but who wants PCI

    International Nuclear Information System (INIS)

    Le Chevalier, T.; Arriagada, R.

    1997-01-01

    With 175 000 new cases annually, lung cancer is the most frequent malignancy in adults in the European Community. Approximately 20% of these tumours are of the small cell subtype and roughly a third, chiefly when disease is confined to the thorax, will be in complete remission after aggressive induction therapy combining multidrug chemotherapy (CT) and thoracic radiation therapy. However, the majority of these patients will relapse and ultimately only 15-20% of complete responders will be long-term survivors (i.e. alive beyond 30 months). The central nervous system (CNS) is one of the main organs invaded by small cell lung cancer (SCLC) and a frequent site of relapse. CNS metastases are found in up to 65% of patients at autopsy with the brain traditionally being considered a sanctuary for tumour cells. Although the blood-brain barrier is supposed to bar the entry to harmful substances (in particular most cytotoxic agents) and thus protect the CNS, this shield does not function systematically since dramatic responses to CT have been achieved in brain metastases from SCLC and brain metastases also arise even when clear responses are being observed at all other sites. Alternatively, the spectacular radiosensitivity of SCLC, which has been well established for decades, prompted the strategy of delivering prophylactic cranial irradiation (PCI) during induction treatment in order to prevent the development of metastases and their cohort of clinical symptoms. (author)

  18. Identification de modèle ARMA à sortie quantifiée par la méthode de maximum de vraisemblances

    Directory of Open Access Journals (Sweden)

    B. LATRECHE

    2015-03-01

    Full Text Available Dans cet article nous présentons une étude détaillée sur une méthode d'identification paramétrique de modèle ARMA (Autorégressive à moyenne ajusté dans le cas où la sortie est quantifiée, nous allons utiliser la méthode de maximum de vraisemblance récursive pour estimer les paramètres de ce modèle (ARMA. Cette méthode est décompose sur deux partie, l'algorithme d'expectation maximisation qui est connu d'essuyer d'un faible taux de convergence. A cette, l'estimation obtenue après quelques itérations EM peut être utilisé pour initialiser une méthode de quasi-Newton. La méthode de maximum de vraisemblance est basée sur la minimisation d'un critère quadratique. La simulation est faite sous le logiciel MATLAB.

  19. Antiplatelet and anticoagulation regimen in patients with mechanical valve undergoing PCI - State-of-the-art review.

    Science.gov (United States)

    Gajanana, Deepakraj; Rogers, Toby; Iantorno, Micaela; Buchanan, Kyle D; Ben-Dor, Itsik; Pichard, Augusto D; Satler, Lowell F; Torguson, Rebecca; Okubagzi, Petros G; Waksman, Ron

    2018-04-02

    A common clinical dilemma regarding treatment of patients with a mechanical valve is the need for concomitant antiplatelet therapy for a variety of reasons, referred to as triple therapy. Triple therapy is when a patient is prescribed aspirin, a P2Y12 antagonist, and an oral anticoagulant. Based on the totality of the available evidence, best practice in 2017 for patients with mechanical valves undergoing percutaneous coronary intervention (PCI) is unclear. Furthermore, the optimal duration of dual antiplatelet therapy after PCI is evolving. With better valve designs that are less thrombogenic, the thromboembolic risks can be reduced at a lower international normalized ratio target, thus decreasing the bleeding risk. This review will offer an in-depth survey of current guidelines, current evidence, suggested approach for PCI in this cohort, and future studies regarding mechanical valve patients undergoing PCI. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry.

    Science.gov (United States)

    Li, Shawn X; Chaudry, Hannah I; Lee, Jiyong; Curran, Theodore B; Kumar, Vishesh; Wong, Kendrew K; Andrus, Bruce W; DeVries, James T

    2018-02-01

    Very elderly patients (age ≥ 85 years) are a rapidly increasing segment of the population. As a group, they experience high rates of in-hospital mortality and bleeding complications following percutaneous coronary intervention (PCI). However, the relationship between bleeding and mortality in the very elderly is unknown. Retrospective review was performed on 17,378 consecutive PCI procedures from 2000 to 2015 at Dartmouth-Hitchcock Medical Center. Incidence of bleeding during the index PCI admission (bleeding requiring transfusion, access site hematoma > 5 cm, pseudoaneurysm, and retroperitoneal bleed) and in-hospital mortality were reported for four age groups (PCI. Incidence of bleeding and in-hospital mortality increased monotonically with increasing age (mortality: 0.94%, 2.27%, 4.24% and 4.58%; bleeding: 3.96%, 6.62%, 10.68% and 13.99% for ages PCI increase with increasing age. For the very elderly, despite high rates of bleeding, bleeding is no longer predictive of in-hospital mortality following PCI.

  1. Le modèle judiciaire libéral mis à l’épreuve : la surveillance des juges sous le Directoire

    OpenAIRE

    Berger, Emmanuel

    2007-01-01

    La justice du Directoire est principalement identifiée aux différentes violations infligées par le gouvernement afin de contrôler le pouvoir judiciaire et durcir la répression criminelle. Cette représentation est, en réalité, partiale. L’auteur tente de le prouver à travers l’analyse d’un aspect essentiel du système judiciaire directorial : la surveillance des juges. L’étude des normes et des pratiques montre que le mode de surveillance établi par le code des délits et des peines respecte la ...

  2. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

    Science.gov (United States)

    Ponader, Sabine; Chen, Shih-Shih; Buggy, Joseph J.; Balakrishnan, Kumudha; Gandhi, Varsha; Wierda, William G.; Keating, Michael J.; O'Brien, Susan; Chiorazzi, Nicholas

    2012-01-01

    B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by inhibitors of BCR-associated kinases, such as Bruton tyrosine kinase (Btk). PCI-32765, a selective, irreversible Btk inhibitor, is a novel, molecularly targeted agent for patients with B-cell malignancies, and is particularly active in patients with CLL. In this study, we analyzed the mechanism of action of PCI-32765 in CLL, using in vitro and in vivo models, and performed correlative studies on specimens from patients receiving therapy with PCI-32765. PCI-32765 significantly inhibited CLL cell survival, DNA synthesis, and migration in response to tissue homing chemokines (CXCL12, CXCL13). PCI-32765 also down-regulated secretion of BCR-dependent chemokines (CCL3, CCL4) by the CLL cells, both in vitro and in vivo. In an adoptive transfer TCL1 mouse model of CLL, PCI-32765 affected disease progression. In this model, PCI-32765 caused a transient early lymphocytosis, and profoundly inhibited CLL progression, as assessed by weight, development, and extent of hepatospenomegaly, and survival. Our data demonstrate that PCI-32765 effectively inhibits CLL cell migration and survival, possibly explaining some of the characteristic clinical activity of this new targeted agent. PMID:22180443

  3. RuvBL2 Is Involved in Histone Deacetylase Inhibitor PCI-24781-Induced Cell Death in SK-N-DZ Neuroblastoma Cells

    Science.gov (United States)

    Zhan, Qinglei; Tsai, Sauna; Lu, Yonghai; Wang, Chunmei; Kwan, Yiuwa; Ngai, Saiming

    2013-01-01

    Neuroblastoma is the second most common solid tumor diagnosed during infancy. The survival rate among children with high-risk neuroblastoma is less than 40%, highlighting the urgent needs for new treatment strategies. PCI-24781 is a novel hydroxamic acid-based histone deacetylase (HDAC) inhibitor that has high efficacy and safety for cancer treatment. However, the underlying mechanisms of PCI-24781 are not clearly elucidated in neuroblastoma cells. In the present study, we demonstrated that PCI-24781 treatment significantly inhibited tumor growth at very low doses in neuroblastoma cells SK-N-DZ, not in normal cell line HS-68. However, PCI-24781 caused the accumulation of acetylated histone H3 both in SK-N-DZ and HS-68 cell line. Treatment of SK-N-DZ with PCI-24781 also induced cell cycle arrest in G2/M phase and activated apoptosis signaling pathways via the up-regulation of DR4, p21, p53 and caspase 3. Further proteomic analysis revealed differential protein expression profiles between non-treated and PCI-24781 treated SK-N-DZ cells. Totally 42 differentially expressed proteins were identified by MALDI-TOF MS system. Western blotting confirmed the expression level of five candidate proteins including prohibitin, hHR23a, RuvBL2, TRAP1 and PDCD6IP. Selective knockdown of RuvBL2 rescued cells from PCI-24781-induced cell death, implying that RuvBL2 might play an important role in anti-tumor activity of PCI-24781 in SK-N-DZ cells. The present results provide a new insight into the potential mechanism of PCI-24781 in SK-N-DZ cell line. PMID:23977108

  4. Le jeu de la création : Le mangeur (2005 de Ying Chen

    Directory of Open Access Journals (Sweden)

    Nicole Dunham

    2013-11-01

    Full Text Available Le théoricien James Hans définit le jeu comme une déconstruction structurante, un processus de perpétuelle remise en question. Dans Le Mangeur (2005 de Ying Chen, la narratrice revit un épisode d’une de ses vies passées où elle meurt mangée, avalée, par son père, descendant dans le « tunnel » du ventre de ce dernier. Cependant, suite à cet événement, elle se retrouve dans un autre espace-temps où elle rencontre son mari, A.. Une équivalence s’établit dans le roman entre les éléments suivants : le ventre du père, les tableaux peints par ce dernier et l’espace-temps de A., et la fenêtre. Ces éléments deviennent des aires de jeu, remettant en question les concepts de l’intérieur et de l’extérieur et du créateur et de l’œuvre. En nous servant du texte « Le Tunnel » écrit par Ying Chen, nous démontrerons que cette notion du jeu s’applique également à l’ensemble de son œuvre.

  5. Tumelo le Moruo

    Directory of Open Access Journals (Sweden)

    Vuyani S. Vellem

    2015-03-01

    Full Text Available Paleng ya rona batho ba batsho, tumelo ya boKreste e fihlile lefatsheng la rona la Afrika Borwa mmoho le dikgoka tsa ditjhaba tsa boPhirima. BoKreste bo fihlile ka nako ya dintwa tseo mohopolo wa tsona e neng e le ho hapa lefatshe la, batho ba batsho. Ka mantswe amang, rona batho ba batsho, re ile ra qetella re le setjhaba se ileng sa hlolwa, mme lefatshe la rona la nkuwa ka dikgoka. Ka hare ho dikgoka tsena, ho ne ho dutse tumelo ya boKreste. Makgowa a ile are: �A re kwaleng mahlo re rapeleng, rona ra kwala mahlo, mme ha re qeta hore Amen, re bula mahlo, ra fumana lefatshe le nkuwe matsohong a rona ho setse Bibele.� Re ile ra sala le Bibele eo ka yona re lekileng dilemong tse fitileng ho lwana ntwa ya topollo, kapa tokoloho hofihlela selemong sa 1994. Le ha re ile ra fumana tokoloho ka selemo seo, hare so ka re lokoloha ho tsa moruo. E kaba sena se bolela eng mabapi le tumelo ya rona ya boKreste? Segolweng sena re leka ho araba potso ena. Tumelo ke eng ho batho ba sa lokolohang moruong wa naha ya bona? Re lekola pale ya boKreste, tumelo ya batho le maemo a kereke ntlheng ya ho tadimana le tokoloho ka tumelo.Faith and economics. In our history from a black perspective, Christianity arrived through violent conquest from the west. Evidentially, this faith coincided with wars of dispossession and the ultimate defeat of black Africans. It is difficult to separate the violent defeat of black Africans from the arrival of Christian faith. This well-known statement within the circles of black Theology of liberation: When the white man arrived in our land he said, �let us pray and after prayer, when we opened our eyes, our land was taken and only the Bible was left in our hands,� captures the black sentiment of this history. Ironically, it was this Bible that black Africans used to wage their struggle for liberation up to the demise of apartheid in 1994.Nonetheless, political liberation is not enough as the struggle for economic liberation

  6. Rapport financier trimestriel pour le trimestre qui a pris fin le 30 juin

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    30 juin 2016 ... Le CRDI finance des travaux de recherche appliquée ... développement international (le Centre) et lʼévolution de la ..... voie de développement et sur la mise en oeuvre des connaissances scientifiques, techniques et autres en vue .... Les accords expirent à des dates différentes, et le dernier prend fin en.

  7. Evaluation of the safety and efficacy of an edoxaban-based antithrombotic regimen in patients with atrial fibrillation following successful percutaneous coronary intervention (PCI) with stent placement: Rationale and design of the ENTRUST-AF PCI trial.

    Science.gov (United States)

    Vranckx, Pascal; Lewalter, Thorsten; Valgimigli, Marco; Tijssen, Jan G; Reimitz, Paul-Egbert; Eckardt, Lars; Lanz, Hans-Joachim; Zierhut, Wolfgang; Smolnik, Rüdiger; Goette, Andreas

    2018-02-01

    The optimal antithrombotic treatment after percutaneous coronary intervention (PCI) with stenting in patients with atrial fibrillation (AF) is unknown. In the ENGAGE AF-TIMI 48 trial, edoxaban was noninferior to a vitamin K antagonist (VKA) with respect to the prevention of stroke or systemic embolism and was associated with significantly lower rates of bleeding and cardiovascular death in patients with nonvalvular AF. The effects of edoxaban in combination with single- or dual-antiplatelet therapy in the setting of PCI are unexplored. The ENTRUST-AF PCI trial is a multinational, multicenter, randomized, open-label phase 3b trial with blinded end point evaluation involving 1,500 patients on oral anticoagulation for AF. Patients are randomized between 4 hours and 5 days after successful PCI to either an edoxaban-based strategy (experimental arm; 60 mg [or 30 mg according to dose reduction criteria] once daily plus a P2Y 12 antagonist [default clopidogrel, 75 mg once daily] for 12 months) or a VKA-based strategy (control arm; VKA plus a P2Y 12 antagonist [as above] plus acetylsalicylic acid [100 mg once daily] for 30 days to 12 months). The primary safety end point is the incidence of International Society on Thrombosis and Haemostasis-defined major or clinically relevant nonmajor bleeding. The main efficacy end point is the composite of cardiovascular death, stroke, systemic embolic events, spontaneous myocardial infarction, and definite stent thrombosis. The ENTRUST-AF PCI trial tests the hypothesis that an edoxaban-based antithrombotic strategy reduces the risk of bleeding complications after PCI compared with VKA plus conventional dual-antiplatelet therapy in patients with AF in need of oral anticoagulation. The relative risk of ischemic events between groups will be compared. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  8. Stranieri e vicini: le banche attraverso le frontiere del nord America. (Strangers and neighbours: cross-border banking in North America

    Directory of Open Access Journals (Sweden)

    J.W. DEAN

    2013-12-01

    Full Text Available L'articolo si occupa di aspetti normativi e competitivi della penetrazione reciproca da parte delle banche canadesi e statunitensi nei rispettivi mercati nazionali . Gli autori valutano il grado in cui i fattori economici sono gli unici responsabili per la differenza nei tassi di crescita tra le banche nazionali ed estere in Nord America. Essi sostengono che il regolamento non ha inciso sullala crescita delle banche estere in Nord America affrontando la questione della reciprocità in regolamenti bancari , prima di esaminare le banche estere negli Stati Uniti e il modo in cui sono state regolamentate .The paper is concerned with regulatory and competitive aspects of the mutual penetration by Canadian and U.S. banks of each other’s domestic markets. The authors assess the degree to which economic factors alone are responsible for the difference in growth rates between domestic and foreign banks in North America. They argue that regulation has not affected the growth of foreign banks in North America by addressing the question of reciprocity in banking regulations, before examining foreign banks in the U.S. and the manner in which they have been regulated. U.S. banks operating in Canada are then dealt with. Finally, the results of an empirical test of the proposition that the growth of cross-border banking is attributable to factors other than differential regulation is presented.JEL: G21

  9. La régulation sociale par la violence : lele de la criminalité organisée dans l'Italie méridionale

    OpenAIRE

    Catanzaro, Raimondo

    2006-01-01

    Les activités illicites en Italie semblent avoir atteint, dans la dernière décennie, un niveau "critique". L'Etat italien n'a manifestement plus le monopole de l'usage de la violence sur son propre territoire. Toutefois, le développement de la criminalité dite organisée, qui rentre directement en concurrence avec l'Etat, au titre notamment d'entreprise de protection garante des biens et de la sécurité physique, n'est "possible" que si ce dernier est incapable de tenir et d'assurer sa situatio...

  10. FPGA implementation of PCI to CAMAC interface for Embedded CAMAC Controller (ECC)

    International Nuclear Information System (INIS)

    Jha, K.; Behere, Anita; Ghodgaonkar, M.D.

    2005-01-01

    CAMAC controllers are used for control systems and nuclear physics experiments. Control applications need more number of physically distributed crates with regular scanning of all the parameters, the control being with a centralized computer. On the other hand, nuclear physics experiments need a high throughput with a large number of parameters in one or more crates. The nature of events is random hence buffering of data in LIST mode acquisition is needed. For a large number of parameters, this translates to high transfer rate. Hence it is essential that the CAMAC readout time is minimized and also the data transfer speed is improved to achieve maximum effective throughput. The ECC is designed to achieve these objectives using an embedded controller with PC architecture having PCI bus as interface for add on logic. The PCI Add-on to CAMAC interface protocol has been implemented in an AL TERA FPGA and all the functionality coded in VHDL. This paper discusses the design aspects of the FPGA implementation of the PCI to CAMAC interface. (author)

  11. Design of device driver program for PCI data acquisition adapters based on WDM of windows 2000

    International Nuclear Information System (INIS)

    Yuan Weihua; Qiao Weimin; Jing Lan; Zhu Haijun

    2003-01-01

    The paper describes the design of device driver program for PCI data acquisition adapters based on WDM of Windows 2000. Give an actual example of PCI6208. Now, several data acquisition adapters based in this method are using in national big science engineer HIRFL-CSR. (authors)

  12. Impaired health status in Type D patients following PCI in the drug-eluting stent era

    DEFF Research Database (Denmark)

    Pedersen, Susanne S.; Denollet, Johan; Ong, Andrew T L

    2007-01-01

    Drug-eluting stenting reduces restenosis post-percutaneous coronary intervention (PCI), but subgroups of patients may not benefit optimally from this procedure. We examined the impact of Type D personality on health status over time and the clinical relevance of Type D as a predictor of impaired...... health status at 12 months in unselected post-PCI patients....

  13. PCI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease.

    Science.gov (United States)

    Nyström, Thomas; Sartipy, Ulrik; Franzén, Stefan; Eliasson, Björn; Gudbjörnsdottir, Soffia; Miftaraj, Mervete; Lagerqvist, Bo; Svensson, Ann-Marie; Holzmann, Martin J

    2017-09-19

    It is unknown if coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) may offer a survival benefit in patients with type 1 diabetes (T1D) in need of multivessel revascularization. This study sought to determine if patients with T1D and multivessel disease may benefit from CABG compared with PCI. In an observational cohort study, the authors included all patients with T1D who underwent a first multivessel revascularization in Sweden from 1995 to 2013. The authors used the SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies) register, the Swedish National Diabetes Register, and the Swedish National Patient Register to retrieve information about patient characteristics and outcomes. They estimated hazard ratios (HRs) adjusted for confounders with 95% confidence intervals (CIs) for all-cause and coronary heart disease mortality, myocardial infarction, repeat revascularization, stroke, and heart failure using inverse probability of treatment weighting based on propensity scores. In total, 683 patients who underwent CABG and 1,863 patients who underwent PCI were included. During a mean follow-up of 10.6 years, 53% of patients in the CABG group and 45% in the PCI group died. PCI, compared with CABG, was associated with a similar risk of all-cause mortality (HR: 1.14; 95% CI: 0.99 to 1.32), but higher risks of death from coronary heart disease (HR: 1.45; 95% CI: 1.21 to 1.74), myocardial infarction (HR: 1.47; 95% CI: 1.23 to 1.78), and repeat revascularization (HR: 5.64; 95% CI: 4.67 to 6.82). No differences in risks of stroke or heart failure were found. Notwithstanding the inclusion of patients with T1D who might not have been able to undergo CABG in the PCI group we found that PCI, compared with CABG, was associated with higher rates and risks of coronary heart disease mortality, myocardial infarction, and repeat revascularizations. Our

  14. Equazioni: le icone del sapere

    NARCIS (Netherlands)

    Bais, S.

    2009-01-01

    Il mistero del cosmo è scritto nel linguaggio della matematica, e le equazioni sono le frasi che ne esprimono la bellezza e la profondità. Cercare di spiegare la scienza senza equazioni è come cercare di spiegare l’arte senza illustrazioni: partendo da questo presupposto, Sander Bais presenta una

  15. Faire la chose « la plus sensée » pour le Canada et pour le monde ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    18 déc. 2014 ... Je faisais partie de la délégation qui a accompagné dernièrement le gouverneur général du Canada, Son Excellence le très honorable David Johnston, et Son Excellence Sharon Johnston au ... Il avait ensuite a déclaré que ce que le CRDI a fait au Chili, c'est qu'il a permis aux idées de continuer de vivre.

  16. Pórticos, letreiros, lareiras Le Corbusier e Robert Venturi, sobre simbolismo e velocidade no modernismo

    Directory of Open Access Journals (Sweden)

    Rafael Urano Frajndlich

    2010-12-01

    Full Text Available Este artigo procura investigar a leitura que o arquiteto Robert Venturi faz de alguns traços da obra de Le Corbusier, para conceber suas considerações sobre arquitetura e comunicação. Para isso, foram estudadas, de modo breve, as maneiras como Le Corbusier já fazia uso, em sua obra, de algumas categorias que, posteriormente, seriam atribuídas, excelentemente, aos ditos pós-modernos: a retórica, a alusão, a memória dos centro históricos e dos interiores decorados. Tendo em vista a obra geral do arquiteto suíço, é certo que essas categorias aparecem somente nas entrelinhas de seu projeto modernista de reorganização das cidades. Entretanto, uma leitura de minúcias revela alguns temas – especificamente o interesse de Corbusier nos monumentos de Paris, seus pórticos desenhados na Ville contemporaine (1921, e a lareira com motivos surrealistas na cobertura De Beistegui (1929 que seriam objeto de pleno interesse para historiadores e arquitetos da década de 1960. Justamente, nessa recuperação de traços obscuros de Corbusier, Venturi posiciona alguns de seus temas, especificamente em suas soluções residenciais, privilegiando – e, em alguns casos, mesmo exagerando, a imagem chaminé, duplicando sua altura ou colocando-a como grande ordenadora da planta. Todo esse debate será estudado tendo, como pano de fundo, escritos recentes que realizam um balanço crítico das rupturas engendradas pela dita arquitetura pós-moderna com os modernismos. Fazendo uso de considerações de Andreas Huyssen, Paul Virilio e Beatriz Colomina, entre outros, procurou-se ora delimitar, com maior clareza, a fronteira entre essas duas correntes do século 20, ora diluir seus contornos, revelando semelhanças que, eventualmente, fazem-nas indissociáveis.

  17. Le continu contre l'espace

    Science.gov (United States)

    Salanskis, Jean-Michel

    Disons pour conclure que, en tout état de cause, la façon de concevoir philosophiquement le conflit du continu et de l'espace que nous avons trouvée chez Hegel n'est pas homogène avec le style et les modalités de la pensée mathématique: 1) d'une part, le lien classique, le lien de référence entre continu et espace en mathématiques n'est pas que l'espace serait premier et privé de pensée, et le continu second, venant dissoudre l'espace en apportant la qualité, l'infini et la pensée, mais tout au contraire, il consiste en ce que l'espace est fondé sur l'abîme infinitaire du continu ; 2) d'autre part, l'éventuel divorce entre l'espace et le continu dans l'aire mathématique n'est pas celui d'une réflexivité purement conceptuelle du continu avec un positivisme géométrique, n'équivaut pas à une rupture disciplinaire ; il est plutôt le symptôme de la dérive d'une herméneutique à l'égard d'une autre, au sein d'un continent juridique commun définissant la discipline (la mathématique ensembliste), cette dérive pouvant, à la limite, induire une refonte de ce sol juridique, sans que jamais il soit question pour autant de nier l'unité des mathématiques, à comprendre ici comme l'unité ultime de responsabilité de la communauté mathématique à l'égard des trois questions Qu'est-ce que l'espace?”, “Qu'est-ce que le continu?” et “Qu'est-ce que l'infini?”.

  18. Combined PCI and minimally invasive heart valve surgery for high-risk patients.

    Science.gov (United States)

    Umakanthan, Ramanan; Leacche, Marzia; Petracek, Michael R; Zhao, David X; Byrne, John G

    2009-12-01

    Combined coronary artery valvular heart disease is a major cause of morbidity and mortality in the adult patient population. The standard treatment for such disease has been open heart surgery in which coronary artery bypass grafting (CABG) is performed concurrently with valve surgery using a median sternotomy and cardiopulmonary bypass. With the increasing complexity of patients referred to surgery, some patients may prove to be poor surgical candidates for combined valve and CABG surgery. In certain selected patients who fall into this category, valve surgery and percutaneous coronary intervention (PCI) have been considered a feasible alternative. Conventionally, valve surgery is performed in the cardiac surgical operating room, whereas PCI is carried out in the cardiac catheterization laboratory. Separation of these two procedural suites has presented a logistic limitation because it impedes the concomitant performance of both procedures in one setting. Hence, PCI and valve surgery usually have been performed as a "two-stage" procedure in two different operative suites, with the procedures being separated by hours, days, or weeks. Technologic advancements have made possible the construction of a "hybrid" procedural suite that combines the facilities of a cardiac surgical operating room with those of a cardiac catheterization laboratory. This design has enabled the concept of "one-stage" or "one-stop" PCI and valve surgery, allowing both procedures to be performed in a hybrid suite in one setting, separated by minutes. The advantages of such a method could prove to be multifold by enabling a less invasive surgical approach and improving logistics, patient satisfaction, and outcomes in selected patients.

  19. Passando per Milano. Kebba Suwareh, immigrato dal Gambia, e le conseguenze dell’illegalità

    Directory of Open Access Journals (Sweden)

    Alice Bellagamba

    2013-10-01

    Full Text Available Il centro d’accoglienza Naga-Har, l’abitazione del cugino, le carceri di San Vittore e di Bollate sono alcuni dei luoghi tra il 2005 e il 2007 attraversati da Kebba Suwareh - richiedente asilo originario del Gambia (un piccolo paese dell’Africa Occidentale affacciato sull’Oceano Atlantico e circondato su tre lati dal Senegal - mentre aspettava che la sua domanda d’asilo politico fosse valutata dalla commissione territoriale di Milano.

  20. Lele du pharmacien dans la fécondation in vitro

    OpenAIRE

    Hannoun , Odélia

    2017-01-01

    La procréation médicalement assistée regroupe plusieurs techniques venant en aide aux couples ayant des difficultés à concevoir. Environ 15% des couples en age de procréer consultent pour une difficulté à concevoir. Ce véritable problème de société nous incite à réfléchir sur le role que tient le pharmacien en tant que professionnel de santé dans le parcours de fécondation in vitro. Le pharmacien développe une relation étroite avec les patients au comptoir. Il est la pour expliquer le traitem...

  1. Long-term outcomes of coronary artery bypass grafting versus stent-PCI for unprotected left main disease: a meta-analysis.

    Science.gov (United States)

    De Rosa, Salvatore; Polimeni, Alberto; Sabatino, Jolanda; Indolfi, Ciro

    2017-09-06

    Coronary artery bypass graft (CABG) surgery has traditionally represented the standard of care for left main coronary artery (LMCA) disease. However, percutaneous coronary intervention with stent implantation (PCI) has more recently emerged as a valuable alternative. The long-time awaited results of the largest randomized trials on the long-term impact of PCI versus CABG in LMCA disease, the newly published NOBLE and EXCEL studies, revealed contrasting results. Thus, aim of the present meta-analysis was to review the most robust evidence from randomized comparisons of CABG versus PCI for revascularization of LMCA. Randomized studies comparing long-term clinical outcomes of CABG or Stent-PCI for the treatment of LMCA disease were searched for in PubMed, the Chochrane Library and Scopus electronic databases. A total of 5 randomized studies were selected, including 4499 patients. No significant difference between CABG and PCI was found in the primary analysis on the composite endpoint of death, stroke and myocardial infarction (OR = 1·06 95% CI 0·80-1·40; p = 0·70). Similarly, no differences were observed between CABG and PCI for all-cause death (OR = 1·03 95% CI 0·81-1·32; p = 0·81). Although not statistically significant, a lower rate of stroke was registered in the PCI arm (OR = 0·86; p = 0·67), while a lower rate of myocardial infarction was found in the CABG arm (OR = 1·43; p = 0·17). On the contrary, a significantly higher rate of repeat revascularization was registered in the PCI arm (OR = 1·76 95% CI 1·45-2·13; p PCI and CABG for the treatment of LMCA disease in the composite endpoint of death, stroke and myocardial infarction. Hence, a large part of patients with unprotected left main coronary artery disease can be managed equally well by means of both these revascularization strategies.

  2. La rentabilidad del cómic en la enseñanza de la cultura en E/LE

    Directory of Open Access Journals (Sweden)

    Jaume Brines Gandía

    2012-08-01

    Full Text Available El presente trabajo trata sobre el uso del cómic como recurso didáctico en la clase de E/LE para enseñar cultura. Aunque la cultura en la clase de E/LE muchas veces pasa desapercibida, constituye un excelente instrumento para la enseñanza de la lengua extranjera y, sobre todo, para que el futuro aprendiente sepa cómo, cuándo y de qué modo usar la lengua. Antes de desarrollar la presente experiencia práctica, es necesario que tratemos el término cultura y las distintas acepciones que supone.

  3. La rentabilidad del cómic en la enseñanza de la cultura en E/LE

    Directory of Open Access Journals (Sweden)

    Jaume Brines Gandía

    2012-01-01

    Full Text Available El presente trabajo trata sobre el uso del cómic como recurso didáctico en la clase de E/LE para enseñar cultura. Aunque la cultura en la clase de E/LE muchas veces pasa desapercibida, constituye un excelente instrumento para la enseñanza de la lengua extranjera y, sobre todo, para que el futuro aprendiente sepa cómo, cuándo y de qué modo usar la lengua. Antes de desarrollar la presente experiencia práctica, es necesario que tratemos el término cultura y las distintas acepciones que supone.

  4. Bibliographie de l’île de Clipperton – Île de La Passion (1711-2005)

    OpenAIRE

    Jost, Christian

    2008-01-01

    L’île de Clipperton, baptisée « Île de La Passion » par ses découvreurs français en 1711, porte pourtant le nom d’un pirate anglais. Malgré les très courtes périodes d’occupation qu’elle connut au début du XXe siècle et dans les années 1960, son histoire est jalonnée de nombreux écrits. Son intérêt scientifique sur le plan des études environnmentales et les enjeux économique et géopolitique récemment renouvelés conduisent l’auteur à publier ici cette bibliographie de plus de trois cent cinqua...

  5. Le Comunità Tradizionali e la Politica Recente Dell'incentivo Allo Sviluppo

    Directory of Open Access Journals (Sweden)

    Anne Greice Soares Ribeiro Macedo

    2015-12-01

    Full Text Available In questo studio si contestualizza la recente politica brasiliana di incentivo allo sviluppo, istituita con il PAC I e il sucessivo PAC II, per una miglior comprensione della questione ambientale e dellacutizzarsi dei conflitti determinati dalla configurazione del capitalismo globale, che, privo di regole, indebolisce i diritti naturali. In quanto nazione periferica, il Brasile, non senza difficoltà, si inserisce in questo nuovo momento del capitalismo, e proprio da questo suo inserimento emergono le contraddizioni tipiche di un progetto politico che, nel nome del progresso economico, di recente concretizzato in grandi imprese per il commercio di commodities, causa grandi conflitti tra interessi economici e il diritto originario dei popoli indigeni o delle popolazioni tradizionali.

  6. The Influence of Comprehensive Cardiac Rehabilitation on Heart Rate Variability Indices after CABG is More Effective than after PCI.

    Science.gov (United States)

    Szmigielska, Katarzyna; Szmigielska-Kapłon, Anna; Jegier, Anna

    2018-02-01

    The aim of this study was to evaluate the influence of cardiac rehabilitation (CR) on heart rate variability (HRV) indices in men with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). The study population consisted of 131 male patients with CAD prospectively and consecutively admitted to CR after PCI n = 72, or CABG n = 59. Participants performed cycle ergometer interval training for 45 min three times a week for 8 weeks. At baseline and after 8 weeks, all patients underwent the HRV assessment. HRV indices in CAGB survivals were significantly lower in comparison to PCI patients at baseline. Significant increases were seen for SDNN, rMSSD, and HF in the CABG group and only in HF component in PCI group after 8 weeks of CR. Eight weeks of CR seems to be more effective in CABG patients than patients after PCI.

  7. Effects of ticagrelor versus clopidogrel on platelet function in fibrinolytic-treated STEMI patients undergoing early PCI.

    Science.gov (United States)

    Dehghani, Payam; Lavoie, Andrea; Lavi, Shahar; Crawford, Jennifer J; Harenberg, Sebastian; Zimmermann, Rodney H; Booker, Jeff; Kelly, Sheila; Cantor, Warren J; Mehta, Shamir R; Bagai, Akshay; Goodman, Shaun G; Cheema, Asim N

    2017-10-01

    Patients undergoing PCI early after fibrinolytic therapy are at high risk for both thrombotic and bleeding complications. We sought to assess the pharmacodynamic effects of ticagrelor versus clopidogrel in the fibrinolytic-treated STEMI patients undergoing early PCI. Patients undergoing PCI within 24 hours of tenecteplase (TNK), aspirin, and clopidogrel for STEMI were randomized to receive additional clopidogrel 300 mg followed by 75 mg daily or ticagrelor 180 mg followed by 90 mg twice daily. The platelet reactivity units (PRU) were measured with the VerifyNow Assay before study drug administration (baseline) at 4 and 24 hours post-PCI. The primary end point was PRU ≤208 at 4 hours. A total of 140 patients (74 in ticagrelor and 66 in clopidogrel group) were enrolled. The mean PRU values at baseline were similar for the 2 groups (257.8±52.9 vs 259.5±56.7, P=.85, respectively). Post-PCI, patients on ticagrelor, compared to those on clopidogrel, had significantly lower PRU at 4 hours (78.7±88 vs 193.6±86.5, respectively, PPCI frequently had PRU >208. In this high-risk population, ticagrelor provides more prompt and potent platelet inhibition compared with clopidogrel (Funded by Astra Zeneca; NCT01930591, https://clinicaltrials.gov/ct2/show/NCT01930591). Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Changements et alimentation dans le cadre d'une colonisation spontanée: le cas des immigrants de l'Inambari (Pérou

    Directory of Open Access Journals (Sweden)

    1975-01-01

    Full Text Available Le secteur appelé San Gabán/lnambari (district de San Gabán, province de Carabaya, Puno situé sur les derniers contreforts de la Cordillère Nevada de Carabaya, est peuplé par des immigrants des hauts plateaux - plus particulièrement des provinces de Melgar et de Carabaya mais aussi de quelques districts de la province d'Azangaro - qui y sont confrontés, en l'absence d'une voie de communication, avec des conditions particulières d'isolement géographique, culturel, économique et politique. Cette transplantation dans la forêt vierge - mouvement migratoire spontané - pose aux immigrants, qu'ils soient permanents ou temporaires, de nombreux problèmes d'adaptation, problèmes d'autant plus importants que les colons abordent les terres basses sans aucune préparation psychologique, éducative et technique. On examine ici le comportement et les réactions des individus dans le domaine de l'alimentation. La première partie de l'étude est consacrée aux composants de l'alimentation. Cette dernière repose avant tout sur les végétaux cultivés et plus particulièrement sur le riz, le manioc, le maïs, les « papas japonesas » et les bananes. Elle est irrégulièrement complétée par les produits de la basse-cour, par un peu de gibier et de poisson et par des denrées que les immigrants font venir ou rapportent de leur village d'origine à l'occasion de leurs voyages périodiques. Parmi ces denrées figurent surtout le chuño, la farine de chuño, la farine d'orge, la cañihua, le charqui, les pâtes, l'huile, le sucre et le sel. On ne peut manquer d'être frappé par le parallélisme existant entre les aliments adoptés et ceux dont l'immigrant se nourrissait dans son district d'origine. On remarque que la satisfaction des besoins alimentaires pose à l'individu un sérieux problème d'adaptation aux ressources locales. Cette adaptation est lente car l'immigrant adopte envers le milieu, semble-t-il, une attitude défensive. Sa m

  9. Construire les stratégies avec le Balanced Scorecard:vers une approche interactive du modèle de Kaplan et Norton

    OpenAIRE

    Gérald Naro; Denis Travaillé

    2010-01-01

    (VF)L’objectif de cet article est de confronter le Balanced Scorecard avec le modèle des leviers de contrôle de Simons (1995) et de discuter de son rôle dans les différentes phases du processus stratégique. Nous privilégions une représentation du BSC comme outil de contrôle interactif. Notre recherche est fondée sur une méthodologie longitudinale de type recherche action à partir de l’étude de deux cas. Les résultats montrent que le BSC crée un processus de construction collective favorisant ...

  10. L'UTILISATION DE LA PENSÉE LEAN DANS LE CONTEXTE DE LA RESPONSABILITÉ SOCIALE DE L'ENTREPRISE

    Directory of Open Access Journals (Sweden)

    Sorin BRICIU

    2016-06-01

    Full Text Available La responsabilité sociale est un concept toujours plus présent dans l'économie actuelle. Les préoccupations des entreprises dans ce domaine sont dues aux avantages apportés par la mise en pratique de ce concept à moyen et à long terme. Étant donné l'intérêt progressif manifesté envers la responsabilité sociale d'une part, vue comme facteur compétitif pour le succès d'une affaire, et de la pensée lean d'autre part, comme étant la plus importante philosophie de management de notre époque, le but de cet article est de présenter les deux concepts et d'analyser la relation d'entre eux. Les résultats de la recherche ont mis en évidence le fait que la littérature spécialisée offre des arguments forts concernant la relation d'entre la pensée lean et la responsabilité sociale, mais les entreprises qui ont mis en pratique la pensée lean dans leurs activités peuvent être considérées comme des entreprises socialement responsables.

  11. Short- and Long-Term Cause of Death in Patients Treated With Primary PCI for STEMI

    DEFF Research Database (Denmark)

    Pedersen, Frants; Butrymovich, Vitalij; Kelbæk, Henning

    2014-01-01

    BACKGROUND: Short-term mortality has been studied thoroughly in patients undergoing primary percutaneous coronary intervention (PCI), whereas long-term cause of death in patients with ST-segment elevation myocardial infarction (STEMI) remains unknown. OBJECTIVES: The goal of this study was to des......BACKGROUND: Short-term mortality has been studied thoroughly in patients undergoing primary percutaneous coronary intervention (PCI), whereas long-term cause of death in patients with ST-segment elevation myocardial infarction (STEMI) remains unknown. OBJECTIVES: The goal of this study...... was to describe the association between time and cause of death in patients with STEMI undergoing primary PCI. METHODS: A centralized civil registration system, patient files, and public disease and death cause registries with an accurate record linkage were used to trace time and cause of death in 2......,804 consecutive patients with STEMI (age 63 ± 13 years, 72% males) treated with primary PCI. RESULTS: Patients were followed up for a median of 4.7 years. During a total of 13,447 patient-years, 717 patients died. Main causes of death within the first 30 days were cardiogenic shock and anoxic brain injury after...

  12. Editorial L&E, v.8, n.1, 2014

    Directory of Open Access Journals (Sweden)

    Rede Conpadre

    2014-02-01

    Full Text Available A Revista Labor & Engenho chega ao seu oitavo ano (quinto com periodicidade trimestral apresentando aos leitores uma atualização do seu layout — que permanece o mesmo, porém com o design levemente modificado a fim de otimizar o corpo do texto e ressaltar no cabeçalho o nome por extenso e a sigla [L&E] da Revista. Também o design das bandeiras correspondentes às diferentes nacionalidades representadas por cada autor da Revista receberam um toque especial a fim de promover um certo destaque. As modificações, embora sutis, contribuem para a consolidação do caráter internacional da Revista Labor & Engenho [ISSN: 2176-8846]. O número 1 do volume 8 (2014 traz 7 artigos: 4 de autores brasileiros (dentre os quais, 3 em português, 1 em inglês; 2 de autores argentinos (em espanhol; e 1 de autor mexicano (em espanhol. Dentre os artigos brasileiros encontram-se representantes de instituições dos estados de São Paulo, Minas Gerais, Espírito Santo, e Rio Grande do Sul. Os artigos argentinos, assim como o artigo mexicano, apresentam aspectos regionais distintos que contribuem para a consolidação da Revista L&E como uma publicação relevante para quem quer que se interesse pelos temas de Trabalho [Labor] & Genialidade [Engenho], Patrimônio & Desenvolvimento Regional, ou Paisagem & Engenharia, ou ainda, Ordenamento Territorial & Sustentabilidade. O primeiro artigo deste número trata das relações existentes entre os meios urbano e rural, a partir de uma análise sobre os padrões de consumo, comportamento e tipo de ocupação no interior de Minas Gerais. O estudo realizado permitiu inferir sobre a necessidade de se incrementar pesquisas sobre o meio rural e as pequenas cidades no Brasil, a fim de conhecer melhor esses espaços e o sistema urbano brasileiro (SOARES; SIOLARI; DIAS, 2014. E já que estamos focados na paisagem rural de Minas Gerais, então a leitura do próximo artigo mostra-se pertinente e instigante. Apresenta-se uma

  13. Le fascisme, c’est du théâtre. Macchina scenica e meccanica narrativa

    Directory of Open Access Journals (Sweden)

    Emanuele Canzaniello

    2015-11-01

    Full Text Available «Le fascisme, c’est du théâtre», sostiene Jean Genet, e come tale i suoi legami con la natura e la prassi della messa in scena sono essenziali alla specificità del fenomeno. La resa spettacolare della nazionalizzazione delle masse è stata senz’altro tra i temi fondamentali della ricerca sui totalitarismi. Il mio proposito è qui quello di intarsiare alcuni nuclei consolidati della ricerca storica con le rese squisitamente letterarie di quello che fu poco più che un  decennio di immensi tableaux vivants, visioni di un nuovo ordine di massa. Un’opera d’arte collettiva, basata su una premessa  fondamentale: dare “figurabilità” ai detriti e alle rovine (rimosse? di alcuni miti delle origini propri della cultura romantica, e  consapevolmente avviare e mettere in luce un enorme processo più generale di disgregazione del logos e di tutta la civiltà europea nella sua prospettiva diremo cartesiana, geometrica e razionalista. Il mio discorso si fonda, anche se in breve, su un testo solo: la Gerbe des forces (1937 di A. de Châteaubriant, uno dei più singolari resoconti di pellegrinaggio politico verso il miraggio totalitario che si sia dato tre le due guerre mondiali. Soccorsi non secondari sono il saggio di Sontag Under the sign of Saturn (1980 e quello di Tame La Mystique du Fascisme dans l’oeuvre de Robert Brasillach (1986. According to Jean Genet: «Le fascisme, c’est du théâtre», and as such its relationship with the nature and praxis of staging are essential to the specificity of the phenomenon. The magnificent representation of mass nationalisation is beyond doubt one of the fundamental issues when investigating totalitarianisms. My aim here is to link some wellestablished nuclei of historical research to the literary outputs of what was little more than a decade of immense tableaux vivants, visions of a new mass order. A collective work of art, based on a fundamental premise: to give ‘figurality’ to the rubble

  14. CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in 2018.

    Science.gov (United States)

    Ozaki, Yukio; Katagiri, Yuki; Onuma, Yoshinobu; Amano, Tetsuya; Muramatsu, Takashi; Kozuma, Ken; Otsuji, Satoru; Ueno, Takafumi; Shiode, Nobuo; Kawai, Kazuya; Tanaka, Nobuhiro; Ueda, Kinzo; Akasaka, Takashi; Hanaoka, Keiichi Igarashi; Uemura, Shiro; Oda, Hirotaka; Katahira, Yoshiaki; Kadota, Kazushige; Kyo, Eisho; Sato, Katsuhiko; Sato, Tadaya; Shite, Junya; Nakao, Koichi; Nishino, Masami; Hikichi, Yutaka; Honye, Junko; Matsubara, Tetsuo; Mizuno, Sumio; Muramatsu, Toshiya; Inohara, Taku; Kohsaka, Shun; Michishita, Ichiro; Yokoi, Hiroyoshi; Serruys, Patrick W; Ikari, Yuji; Nakamura, Masato

    2018-04-01

    While primary percutaneous coronary intervention (PCI) has significantly contributed to improve the mortality in patients with ST segment elevation myocardial infarction even in cardiogenic shock, primary PCI is a standard of care in most of Japanese institutions. Whereas there are high numbers of available facilities providing primary PCI in Japan, there are no clear guidelines focusing on procedural aspect of the standardized care. Whilst updated guidelines for the management of acute myocardial infarction were recently published by European Society of Cardiology, the following major changes are indicated; (1) radial access and drug-eluting stent over bare metal stent were recommended as Class I indication, and (2) complete revascularization before hospital discharge (either immediate or staged) is now considered as Class IIa recommendation. Although the primary PCI is consistently recommended in recent and previous guidelines, the device lag from Europe, the frequent usage of coronary imaging modalities in Japan, and the difference in available medical therapy or mechanical support may prevent direct application of European guidelines to Japanese population. The Task Force on Primary Percutaneous Coronary Intervention of the Japanese Association of Cardiovascular Intervention and Therapeutics (CVIT) has now proposed the expert consensus document for the management of acute myocardial infarction focusing on procedural aspect of primary PCI.

  15. pour le trimestre qui a pris fin le 30 septembre 2016

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    30 sept. 2016 ... Le CRDI finance des travaux de recherche appliquée ... internationales dʼinformation financière (normes IFRS). ..... voie de développement et sur la mise en oeuvre des connaissances scientifiques, techniques et autres en vue du .... Les accords expirent à des dates différentes, et le dernier prend fin en.

  16. Fractional flow reserve-guided PCI for stable coronary artery disease

    DEFF Research Database (Denmark)

    De Bruyne, Bernard; Fearon, William F; Pijls, Nico H J

    2014-01-01

    .80 received medical therapy alone and were included in a registry. The primary end point was a composite of death from any cause, nonfatal myocardial infarction, or urgent revascularization within 2 years. RESULTS: The rate of the primary end point was significantly lower in the PCI group than in the medical......-therapy group (8.1% vs. 19.5%; hazard ratio, 0.39; 95% confidence interval [CI], 0.26 to 0.57; Pgroup (4.0% vs. 16.3%; hazard ratio, 0.23; 95% CI, 0.14 to 0.38; Pgroup differences...... in the rates of death and myocardial infarction. Urgent revascularizations that were triggered by myocardial infarction or ischemic changes on electrocardiography were less frequent in the PCI group (3.4% vs. 7.0%, P=0.01). In a landmark analysis, the rate of death or myocardial infarction from 8 days to 2...

  17. THROMBOLYSIS OR PRIMARY PCI FOR MYOCARDIAL INFARCTION WITH ST-SEGMENT ELEVATION? THE STREAM TRIAL (STRATEGIC REPERFUSION EARLY AFTER MYOCARDIAL INFARCTION

    Directory of Open Access Journals (Sweden)

    V. A. Sulimov

    2013-01-01

    Full Text Available Ambiguous data about comparability regarding clinical outcomes for prehospital thrombolysis, coupled with timely coronary angiography, and primary percutaneous coronary intervention (PCI in the early after acute ST-segment elevation myocardial infarction (STEMI, there are now.In the STREAM trial 1892 patients with STEMI diagnosed within 3 hours after onset of symptoms, and whom it was impossible to perform primary PCI within 1 h after the first medical contact, were randomly assigned into two treatment groups: a primary PCI b prehospital thrombolytic therapy with bolus tenecteplase (dose decreased by half in patients aged ≥75 years in combination with clopidogrel and enoxaparin followed by admission to the hospital, where it was possible to perform PCI. Emergency coronary angiography performed if thrombolysis failed. Coronary angiography and PCI of the infarct-related artery were performed in the period from 6 to 24 hours after randomization and thrombolytic therapy in the case of an effective thrombolysis. Primary endpoints include a composite of death, shock, congestive heart failure, or reinfarction up to 30 days.The primary endpoint occurred in 116 of 939 patients (12.4 % of the thrombolysis group and in 135 of 943 patients (14.3% of the primary PCI group (relative risk in the group thrombolysis 0.86, 95% confidence interval 0.68-1.09, p=0.21. Emergency angiography was required in 36.3% of patients in the thrombolysis, and the remaining patients, coronary angiography and PCI were performed at a mean of 17 hours after randomization and thrombolytic therapy. Thrombolysis group had more intracranial hemorrhages than primary PCI group (1.0% vs 0.2%, p=0.04; after correction protocol and dose reduction by half of tenecteplase in patients ≥75 years: 0.5% vs. 0.3%, p=0.45. The rate of non- intracranial bleeding in two treatment groups did not differ.Prehospital thrombolysis followed by coronary angiography and timely PCI provide effective

  18. 128 Channel PCI-based data acquisition system for MDSplus

    Energy Technology Data Exchange (ETDEWEB)

    Llobet, Xavier E-mail: xavier.llobet@epfl.ch; Duval, Basil P. E-mail: basil.duval@epfl.ch

    2002-06-01

    With the increasing demand for analogue channel acquisition on the TCV tokamak, a new PCI based acquisition has been specified, designed, built and installed into our MDSplus acquisition environment. The design criteria were to not only improve the cost/channel, as compared to our conventional hub based acquisition (CAMAC), but to provide some distributed processing power to avoid the associated acquisition server saturation, both in terms of CPU and network bandwidth. These units were initially intended to satisfy the requirements of general variable rate acquisition from a variety of sources, and many channel acquisition from modern multi-channel diagnostics. Hosted by a i386-Linux PC in a crate with four available PCI slots, each single-PCI slot 32-channel digitiser features sampling frequencies up to 200 kHz, and 64 MB of memory, providing 1 Msample of 16-bit data per channel. The local hard disk is used for immediate local storage of all the acquired data from the selected channels into a local MDSplus database. The host is then accessed as a MDS/IP server that provides, on demand, down-sampled and software filtered traces. The local hard disk capacity is used for medium to long-term storage and availability of the full data set with optional mirror technology to guard against hard disk failure. We have thus obtained a general solution for high resolution, multi-channel routine acquisition using the multi-platform MDSplus environment, in which different software and hardware architectures are intelligently linked across a standard TCP/IP network. The implementation presented here uses ONLY standard components of the MDSplus environment.

  19. 128 Channel PCI-based data acquisition system for MDSplus

    International Nuclear Information System (INIS)

    Llobet, Xavier; Duval, Basil P.

    2002-01-01

    With the increasing demand for analogue channel acquisition on the TCV tokamak, a new PCI based acquisition has been specified, designed, built and installed into our MDSplus acquisition environment. The design criteria were to not only improve the cost/channel, as compared to our conventional hub based acquisition (CAMAC), but to provide some distributed processing power to avoid the associated acquisition server saturation, both in terms of CPU and network bandwidth. These units were initially intended to satisfy the requirements of general variable rate acquisition from a variety of sources, and many channel acquisition from modern multi-channel diagnostics. Hosted by a i386-Linux PC in a crate with four available PCI slots, each single-PCI slot 32-channel digitiser features sampling frequencies up to 200 kHz, and 64 MB of memory, providing 1 Msample of 16-bit data per channel. The local hard disk is used for immediate local storage of all the acquired data from the selected channels into a local MDSplus database. The host is then accessed as a MDS/IP server that provides, on demand, down-sampled and software filtered traces. The local hard disk capacity is used for medium to long-term storage and availability of the full data set with optional mirror technology to guard against hard disk failure. We have thus obtained a general solution for high resolution, multi-channel routine acquisition using the multi-platform MDSplus environment, in which different software and hardware architectures are intelligently linked across a standard TCP/IP network. The implementation presented here uses ONLY standard components of the MDSplus environment

  20. Decreased Time from 9-1-1 Call to PCI among Patients Experiencing STEMI Results in a Decreased One Year Mortality.

    Science.gov (United States)

    Studnek, Jonathan R; Infinger, Allison; Wilson, Hadley; Niess, Gary; Jackson, Patrick; Swanson, Doug

    2018-03-29

    The impact on mortality due to prompt recognition of ST-segment Elevation Myocardial Infarction (STEMI) patients by EMS has not been well described. The objective of this study was to describe the association between the time interval, 9-1-1 call to percutaneous intervention (PCI), and mortality at one year. This retrospective analysis included patients that were transported by EMS as a "code STEMI" and underwent PCI.  Total time from 9-1-1 call to PCI was calculated for each patient and was the independent variable of interest. Each patient's mortality status at one year was the outcome variable, collected by querying medical records and the national death index. Confounding variables were abstracted from hospital records. Logistic regression was conducted to determine the likelihood of survival given differences in time to PCI. A total of 550 patients were included in the analyses of which 68% were male with an average age 59.8 (SD 12.8). Mean reperfusion time was 81.8 min (SD 20.0) and was significantly lower in patients alive at one year (80.8 min, SD 19.7) vs. deceased at one year (93.9 min, SD 19.6), respectively. Odds of survival at one year decreased by 3% (OR 0.97; 95% CI 0.96-0.99) for every one minute increase in time to PCI. This relationship practically represents a 30% increase in mortality for every 10 minute delay from 9-1-1 call to PCI. The model produced suggests that a linear relationship exists between time to PCI and mortality in the prehospital environment with the probability of survival decreasing significantly as time to PCI increases.

  1. Le glaive et la chair : le pouvoir et son incarnation au temps des derniers Valois

    OpenAIRE

    Roux, Nicolas Le

    2014-01-01

    Au xvie siècle, pouvait-on concevoir la monarchie autrement qu’incarnée ? Servir le roi, c’était servir un prince auquel on était lié personnellement, et non une institution abstraite. Le monarque devait apparaître comme un compagnon pour la noblesse militaire. Henri II représentait le modèle du roi chevalier. Contrairement à son père, Charles IX ne faisait pas la guerre, mais il épuisait son corps dans d’interminables chasses. Henri III a tenu dans sa jeunesse lele de chef de guerre. Deve...

  2. Effect of intracoronary nitroprusside injection on flow recovery during primary PCI in acute STEMI patients.

    Science.gov (United States)

    Yang, Lixia; Mu, Lihua; Sun, Linhui; Qi, Feng; Guo, Ruiwei

    2017-04-01

    The no/slow reflow phenomenon during primary percutaneous coronary intervention (PPCI) causes the destruction of the coronary microcirculation and further myocardial damage. Some studies have shown that intracoronary nitroprusside infusion is a safe and effective method for managing the no/slow reflow phenomenon. However, it is uncertain whether the injection of nitroprusside at a specific time point during PPCI can most effectively prevent no-reflow. In this study, we investigated the effect of the timing of an intracoronary nitroprusside injection on flow recovery during PPCI in patients with ST elevation acute myocardial infarction (STEMI). One hundred twenty consecutive patients with STEMI who underwent PPCI were enrolled in the study. Patients who fulfilled the eligibility criteria were randomly allocated to three groups: control group (N.=40) received no nitroprusside before they completed PCI; the second group (N.=40) received nitroprusside before balloon dilatation; and the third group (N.=40) received nitroprusside after each balloon dilatation and before contrast agent refilling. The baseline clinical variables and the details of the PCI procedure were collected. The thrombolysis in myocardial infarction (TIMI) flow grades and the corrected TIMI frame count (cTFC) were evaluated immediately after stent implantation was completed. There were no significant differences in the baseline characteristics, antithrombotic drugs given before PCI, and details of the PCI procedure among the three groups (P>0.05). The incidence of TIMI grade 3 after PCI was significantly higher in the nitroprusside group than in the control group (P=0.025), whereas cTFC was significantly lower in the nitroprusside group (26.6±15.2) than in the control group (38.1±21.3, P=0.001). The incidence of TIMI grade 3 after PCI was significantly higher in the third group than in the second group (P=0.045), and cTFC was significantly lower in the third group (21.5±9.5) than in the second

  3. The Current Status of Percutaneous Coronary Intervention in Korea: Based on Year 2014 Cohort of Korean Percutaneous Coronary Intervention (K-PCI) Registry.

    Science.gov (United States)

    Jang, Jae-Sik; Han, Kyoo-Rok; Moon, Keon-Woong; Jeon, Dong Woon; Shin, Dong-Ho; Kim, Jung-Sun; Park, Duk-Woo; Kang, Hyun-Jae; Kim, Juhan; Bae, Jang-Whan; Hur, Seung-Ho; Kim, Byung Ok; Choi, Donghoon; Gwon, Hyeon-Cheol; Kim, Hyo-Soo

    2017-05-01

    Although several multicenter registries have evaluated percutaneous coronary intervention (PCI) procedures in Korea, those databases have been limited by non-standardized data collection and lack of uniform reporting methods. We aimed to collect and report data from a standardized database to analyze PCI procedures throughout the country. Both clinical and procedural data, as well as clinical outcomes data during hospital stay, were collected based on case report forms that used a standard set of 54 data elements. This report is based on 2014 Korean PCI registry cohort data. A total of 92 hospitals offered data on 44967 PCI procedures. The median age was 66.0 interquartile range 57.0-74.0 years, and 70.3% were men. Thirty-eight percent of patients presented with acute myocardial infarction and one-third of all PCI procedures were performed in an urgent or emergency setting. Non-invasive stress tests were performed in 13.9% of cases, while coronary computed tomography angiography was used in 13.7% of cases prior to PCI. Radial artery access was used in 56.1% of all PCI procedures. Devices that used PCI included drug-eluting stent, plain old balloon angioplasty, drug-eluting balloon, and bare-metal stent (around 91%, 19%, 6%, and 1% of all procedures, respectively). The incidences of in-hospital death, non-fatal myocardial infarction, and stroke were 2.3%, 1.6%, and 0.2%, respectively. These data may provide an overview of the current PCI practices and in-hospital outcomes in Korea and could be used as a foundation for developing treatment guidelines and nationwide clinical research.

  4. Microrrelatos en la red. Desarrollando la escritura creativa a través de Twitter en la clase de E/LE

    Directory of Open Access Journals (Sweden)

    Ricardo Enguix Barber

    2016-11-01

    Full Text Available El propósito de esta propuesta didáctica consiste en desarrollar la expresión escrita a través de la composición de microrrelatos de forma colaborativa, haciendo uso de la plataforma de microblogging Twitter, y la autocorrección de los mismos por parte de los alumnos. Palabras clave: microrrelato, expresión escrita, escritura colaborativa, Twitter, E/LE, autocorrección. Micro-stories in the Net. Developing the creative writing using Twitter in the E/LE classroom Abstract: The aim of this didactic proposal consists in developing the writing skills by means of the collaborative composition of micro-stories, using the micro-blogging platform Twitter, and the self-correction of these micro-stories by the students themselves. Keywords: micro-story, writing skills, collaborative writing, Twitter, E/LE, self-correction.

  5. Impella 2.5 initiated prior to unprotected left main PCI in acute myocardial infarction complicated by cardiogenic shock improves early survival.

    Science.gov (United States)

    Meraj, Perwaiz M; Doshi, Rajkumar; Schreiber, Theodore; Maini, Brijeshwar; O'Neill, William W

    2017-06-01

    To assess post-procedural outcomes when Impella 2.5 percutaneous left ventricular assist device (pLVAD) support is initiated either prior to or after percutaneous coronary intervention (PCI) on unprotected left main coronary artery (ULMCA) culprit lesion in the context of acute myocardial infarction cardiogenic shock (AMICS). Initiation of Impella 2.5 pLVAD prior to PCI is associated with significant survival benefit in the setting of AMICS. Outcomes of those presenting with a ULMCA culprit lesion in this setting have not been well characterized. Thirty-six consecutive patients in the cVAD Registry supported with Impella 2.5 pLVAD for AMICS who underwent PCI on ULMCA culprit lesion were included in our multicenter study. The average age was 69.8 ± 14.2 years, 77.8% were male, 72.7% were in CS at admission, 44.4% sustained one or multiple cardiac arrests, and 30.6% had anoxic brain injury. Baseline characteristics were comparable between the Pre-PCI group (n = 20) and Post-PCI group (n = 16). Non-ST segment elevation myocardial infarction and greater coronary disease burden were significantly more frequent in the Pre-PCI group but they had significantly better survival to discharge (55.0% vs 18.8%, P = 0.041). Kaplan-Meier 30-day survival analysis showed very poor survival in Post-PCI group (48.1% vs 12.5%, Log-Rank P = 0.004). Initiation of Impella 2.5 pLVAD prior to as compared with after PCI of ULMCA for AMICS culprit lesion is associated with significant early survival. As previously described, patients supported after PCI appear to have very poor survival at 30 days. © 2017, Wiley Periodicals, Inc.

  6. L’économie politique du désir dans le rituel et le militantisme au SriLanka

    Directory of Open Access Journals (Sweden)

    Wim Van Daele

    2013-03-01

    Full Text Available Le désir est au cœur des interactions complexes entre le développement et la religion. Cet article examine ses différentes expressions, comme étant une des préoccupations fondamentales de nombreuses religions, qui motivent à la fois le développement et les alternatives au développement. Au SriLanka, face au changement social, la forme néolibérale et mondialisée du développement est comprise et réinterprétée à travers des idiomes et des formations locales du désir. L’économie néolibérale cultive le désir et mène à un accroissement présumé de la présence des preta (fantômes affamés et avides qui se manifestent parfois au moment de la mort d’une personne. Les fantômes affamés, en tant que formations fétichisées du désir, trouvent un écho chez les consommateurs et les entrepreneurs, qui montrent unappétit insatiable vis-à-vis d’une richesse matérielle en constante croissance. Ainsi, l’apaisement ritualisé des fantômes affamés et le militantisme social de groupes tels que le Movement for National Land and Agricultural Reform (MONLAR sont clairement liés par leur préoccupation mutuelle face à l’insécurité existentielle des êtres humains et non humains, causée par un désir excessif et déséquilibré. L’action rituelle et le militantisme social divergent toutefois dans la formulation explicite de leurs préoccupations spécifiques concernant le désir. Le rituel matérialise et condense l’angoisse liée au désir, alors que le militantisme social décrit la fétichisation du désir en termes économiques, politiques et scientifiques plus abstraits.

  7. Le don gratuit. Le cas d'un établissement public

    OpenAIRE

    Barel , Yvan; Frémeaux , Sandrine

    2008-01-01

    Disponible en ligne : http://www.annales.org/gc/2008/gc94/barel.pdf; La logique de la réciprocité est le cadre d'analyse dominant de la relation de travail. La logique du don/contredon s'inscrit dans ce même cadre de référence, en postulant qu'aucune relation d'échange ne peut survivre à une situation d'asymétrie trop forte (MAUSS, 1924). Mais elle ajoute une idée nouvelle en mettant en exergue le " tabou du calcul " (BOURDIEU, 1980) : le désir de contredon n'est pas toujours manifesté, ni mê...

  8. Le paludisme, le tsunami silencieux d'Afrique | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 janv. 2011 ... Dans un élan de compassion fort justifié, le monde s'est porté au secours des victimes du tsunami qui a touché récemment la région de l'océan Indien. Mais il ignore qu'un « tsunami silencieux », le paludisme, s'abat sans cesse sur l'Afrique et y fait chaque année plus de 1,5 million de victimes, surtout de ...

  9. L’annotation et le tag comme supports à l’amélioration de performances en traduction spécialisée

    OpenAIRE

    Dogoriti, Elefthéria; Vyzas, Théodore

    2017-01-01

    Dans cet article, nous nous proposons d'étudier l'usage pédagogique auquel se prête l'outil de partage et de gestion de signets Diigo afin de caractériser le processus de genèse instrumentale d'une formation en traduction spécialisée en présentiel. Nous questionnons par le biais de questionnaires, lele des étiquettes (tags), des annotations flottantes et collantes (floating, in-line sticky notes) ainsi que des surlignages dans les processus de traduction, d'acquisition lexicale et de gesti...

  10. Initiative Think tank | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'ITT est le fruit d'un partenariat regroupant cinq bailleurs de fonds. Lancée en 2008, l'ITT est administrée par le Centre de Recherches pour le Développement International (CRDI), un organisme canadien.

  11. Leïomyosarcome de la prostate: Neoplasie rare

    Directory of Open Access Journals (Sweden)

    D. Basraoui

    2012-03-01

    La TDM et surtout l'IRM jouent un rôle primordial dans le bilan d'extension locale et à distance du léïomyosarcome prostatique et le seul moyen pour affirmer le diagnostic est l'histologie complétée par une étude immuno-histochimique. Leur prise en charge thérapeutique n'est pas codifiée à l'heure actuelle et leur pronostic reste très sombre.

  12. Le FIVB annonce le financement de huit autres projets | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    5 avr. 2018 ... Découvrez les derniers récents projets soutenus par le Fonds d'innovation en matière de vaccins pour le bétail : Maladie de Newcastle · Pleuropneumonie contagieuse caprine – cowdriose · Plateforme de modification génétique CRISPR/cas9 · Entérotoxémie, la bactérie Pasteurella et la fièvre de la vallée ...

  13. Réponse équilibrée aux besoins en eau dans le bassin du Saïss au ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ACCA

    par les changements climatiques. Ce projet du programme ACCA met l'accent sur l'agriculture, à l'origine de plus de 82 % de la consommation d'eau dans le bassin. Réponse équilibrée aux besoins en eaudans le bassin du Saïss au Maroc. De petits exploitants agricoles du bassin du Saïss font face aux pénuries d'eau ...

  14. Effect of rosuvastatin dose-loading on serum sLox-1, hs-CRP, and postoperative prognosis in diabetic patients with acute coronary syndromes undergoing selected percutaneous coronary intervention (PCI).

    Science.gov (United States)

    Jiao, Yungen; Hu, Feng; Zhang, Zhengang; Gong, Kaizheng; Sun, Xiaoning; Li, Aihua; Liu, Naifeng

    2015-01-01

    To investigate the effect of rosuvastatin dose-loading on serum levels of lectin-like oxidized low-density lipoprotein receptor-1 (Lox-1) and high-sensitivity c-reactive protein (hs-CRP) and postoperative prognosis in patients with diabetes and non-ST segment elevation acute coronary syndromes (NSTEACS) undergoing selected percutaneous coronary intervention (PCI). A total of 72 patients with diabetes and NSTEACS were randomized to either the group treated with 20 mg rosuvastatin 12 hours prior to PCI with a second dose administered just before PCI (n = 33), or a control group treated with standard method according guideline (n = 39). Serum levels of sLox-1, hs-CRP, CK-MB, and cTnI were measured prior to PCI, and at 24 hours and 30 days after PCI. The 30-day incidence of major adverse cardiac events (MACE) was recorded in both groups. Compared to pre-PCI, serum levels of sLox-1 and hs-CRP of the two groups were increased at 24 hours after PCI (P PCI (P PCI, the levels of TC and LDL-C were not changed at 24 hours after PCI (P > 0.05) until 30 days after PCI (P PCI; the 30-day incidence of MACE occurred in 6.06% of patients in the loading-dose rosuvastatin-treated group and in 23.08% of patients in the control-treated group (P PCI, and also reduce the occurrence of MACE 30 days after PCI.

  15. Suggestibility, expectancy, trance state effects, and hypnotic depth: II. Assessment via the PCI-HAP.

    Science.gov (United States)

    Pekala, Ronald J; Kumar, V K; Maurer, Ronald; Elliott-Carter, Nancy; Moon, Edward; Mullen, Karen

    2010-04-01

    This study sought to determine if self-reported hypnotic depth (srHD) could be predicted from the variables of the Phenomenology of Consciousness Inventory - Hypnotic Assessment Procedure (PCI-HAP) (Pekala, 1995a, 1995b; Pekala & Kumar, 2007; Pekala et al., 2010), assessing several of the processes theorized by researchers to be associated with hypnotism: trance (altered state effects), suggestibility, and expectancy. One hundred and eighty participants completed the PCI-HAP. Using regression analyses, srHD scores were predicted from the PCI-HAP pre-hypnotic and post-hypnotic assessment items, and several other variables. The results suggested that the srHD scores were found to be a function of imagoic suggestibility, expectancy (both estimated hypnotic depth and expected therapeutic efficacy), and trance state and eye catalepsy effects; effects that appear to be additive and not (statistically) interactive. The results support the theorizing of many investigators concerning the involvement of the aforementioned component processes with this particular aspect of hypnotism, the self-reported hypnotic depth score.

  16. Step-by-step manual for planning and performing bifurcation PCI: a resource-tailored approach.

    Science.gov (United States)

    Milasinovic, Dejan; Wijns, William; Ntsekhe, Mpiko; Hellig, Farrel; Mohamed, Awad; Stankovic, Goran

    2018-02-02

    As bifurcation PCI can often be resource-demanding due to the use of multiple guidewires, balloons and stents, different technical options are sometimes being explored, in different local settings, to meet the need of optimally treating a patient with a bifurcation lesion, while being confronted with limited material resources. Therefore, it seems important to keep a proper balance between what is recognised as the contemporary state of the art, and what is known to be potentially harmful and to be discouraged. Ultimately, the resource-tailored approach to bifurcation PCI may be characterised by the notion of minimum technical requirements for each step of a successful procedure. Hence, this paper describes the logical sequence of steps when performing bifurcation PCI with provisional SB stenting, starting with basic anatomy assessment and ending with the optimisation of MB stenting and the evaluation of the potential need to stent the SB, suggesting, for each step, the minimum technical requirement for a successful intervention.

  17. Storicizzare le teorie psicocritiche

    Directory of Open Access Journals (Sweden)

    Roberto Talamo

    2015-07-01

    Full Text Available Le teorie psicoanalitiche della letteratura, dopo una fase di alterne fortune, sono oggi praticate da una cerchia di adepti sempre più ristretta. Le nuove koinè critico-teoriche tendono infatti a relegare la dottrina freudiana all’interno di un sapere letterario (e non interpretativo o a sostituire ad essa strumenti ritenuti più efficaci nella descrizione della sfera del mentale in letteratura (neuroestetica e neuronarratologia. La proposta storiografica che qui si avanza non vuole prendere parte in questo dibattito pro o contro la psicocritica, ma vuole leggere le proposte di teoria psicoanalitica della letteratura alla luce di una riflessione sul concetto di ibridazione, concetto sul quale queste teorie hanno costruito il loro confronto con i paradigmi teorici di volta in volta egemoni.

  18. Change in coronary blood flow after percutaneous coronary intervention in relation to baseline lesion physiology: results of the JUSTIFY-PCI study.

    Science.gov (United States)

    Nijjer, Sukhjinder S; Petraco, Ricardo; van de Hoef, Tim P; Sen, Sayan; van Lavieren, Martijn A; Foale, Rodney A; Meuwissen, Martijn; Broyd, Christopher; Echavarria-Pinto, Mauro; Al-Lamee, Rasha; Foin, Nicolas; Sethi, Amarjit; Malik, Iqbal S; Mikhail, Ghada W; Hughes, Alun D; Mayet, Jamil; Francis, Darrel P; Di Mario, Carlo; Escaned, Javier; Piek, Jan J; Davies, Justin E

    2015-06-01

    Percutaneous coronary intervention (PCI) aims to increase coronary blood flow by relieving epicardial obstruction. However, no study has objectively confirmed this and assessed changes in flow over different phases of the cardiac cycle. We quantified the change in resting and hyperemic flow velocity after PCI in stenoses defined physiologically by fractional flow reserve and other parameters. Seventy-five stenoses (67 patients) underwent paired flow velocity assessment before and after PCI. Flow velocity was measured over the whole cardiac cycle and the wave-free period. Mean fractional flow reserve was 0.68±0.02. Pre-PCI, hyperemic flow velocity is diminished in stenoses classed as physiologically significant compared with those classed nonsignificant (PPCI, resting flow velocity over the wave-free period increased little (5.6±1.6 cm/s) and significantly less than hyperemic flow velocity (21.2±3 cm/s; P0.80 had a significantly smaller gain (Δ4.6±2.3 cm/s; PPCI physiology is strongly associated with post-PCI increase in hyperemic coronary flow velocity. Hyperemic flow velocity increases 6-fold more when stenoses classed as physiologically significant undergo PCI than when nonsignificant stenoses are treated. Resting flow velocity measured over the wave-free period changes at least 4-fold less than hyperemic flow velocity after PCI. © 2015 American Heart Association, Inc.

  19. Change in Coronary Blood Flow After Percutaneous Coronary Intervention in Relation to Baseline Lesion Physiology Results of the JUSTIFY-PCI Study

    Science.gov (United States)

    Nijjer, Sukhjinder S.; Petraco, Ricardo; van de Hoef, Tim P.; Sen, Sayan; van Lavieren, Martijn A.; Foale, Rodney A.; Meuwissen, Martijn; Broyd, Christopher; Echavarria-Pinto, Mauro; Al-Lamee, Rasha; Foin, Nicolas; Sethi, Amarjit; Malik, Iqbal S.; Mikhail, Ghada W.; Hughes, Alun D.; Mayet, Jamil; Francis, Darrel P.; Di Mario, Carlo; Escaned, Javier; Piek, Jan J.; Davies, Justin E.

    2016-01-01

    Background Percutaneous coronary intervention (PCI) aims to increase coronary blood flow by relieving epicardial obstruction. However, no study has objectively confirmed this and assessed changes in flow over different phases of the cardiac cycle. We quantified the change in resting and hyperemic flow velocity after PCI in stenoses defined physiologically by fractional flow reserve and other parameters. Methods and Results Seventy-five stenoses (67 patients) underwent paired flow velocity assessment before and after PCI. Flow velocity was measured over the whole cardiac cycle and the wave-free period. Mean fractional flow reserve was 0.68±0.02. Pre-PCI, hyperemic flow velocity is diminished in stenoses classed as physiologically significant compared with those classed nonsignificant (PPCI, resting flow velocity over the wave-free period increased little (5.6±1.6 cm/s) and significantly less than hyperemic flow velocity (21.2±3 cm/s; P0.80 had a significantly smaller gain (Δ4.6±2.3 cm/s; PPCI physiology is strongly associated with post-PCI increase in hyperemic coronary flow velocity. Hyperemic flow velocity increases 6-fold more when stenoses classed as physiologically significant undergo PCI than when nonsignificant stenoses are treated. Resting flow velocity measured over the wave-free period changes at least 4-fold less than hyperemic flow velocity after PCI. PMID:26025217

  20. Juego, representación y aprendizaje: Un taller de teatro para alumnos de E/LE

    Directory of Open Access Journals (Sweden)

    Leyre Goitia Pastor

    2007-01-01

    Full Text Available El objetivo de esta presentación es reflexionar sobre una experiencia didáctica con alumnos de español como lengua extranjera (E/LE de EE.UU., en el marco de un taller de teatro.

  1. Le surpoids, l'obésité et le contrôle glycémique chez les diabétiques ...

    African Journals Online (AJOL)

    utilisation et du stockage des sucres apportés par l'alimentation, sa prise en charge est ... l'organisation mondiale de santé (OMS), Le contrôle glycémique a été effectué par l'analyse sanguine de l'Hémoglobine glycosylée et de la Glycémie à jeun.

  2. Le cosmos et le lotus confessions d'un astrophysicien

    CERN Document Server

    Trinh, Xuan Thuan

    2011-01-01

    Que nous dit vraiment la science sur la nature de l'univers, sur son origine et son avenir ? Par quel mystère le langage mathématique, pure création de l'esprit humain, se révèle-t-il aussi performant pour nous décrire les phénomènes physiques, de l'infiniment petit à l'infiniment grand ? S'il existe un ordre du monde, ce que nous en disent la physique quantique et la théorie de la relativité est-il compatible avec ce qu'enseigne le bouddhisme ? Et que peut-on en conclure concernant notre propre vie ? A ces questions passionnantes et à beaucoup d'autres, le célèbre astrophysicien Trinh Xuan Thuan répond ici d'une façon personnelle, en s'appuyant sur son expérience. Son itinéraire l'a placé d'emblée à la confluence de trois cultures : issu d'une famille de lettrés vietnamiens imprégnée de traditions bouddhiste et confucéenne, il a reçu une éducation à la française puis une formation scientifique à l'américaine. Une telle richesse de points de vue lui permet d'apporter, non pas de...

  3. Genética e conservação do leão-baio (Puma concolor) no sul do Brasil

    OpenAIRE

    Camila Schlieper de Castilho

    2010-01-01

    O leão-baio (Puma concolor), segundo maior felino neotropical, tem a maior distribuição geográfica nas Américas. A subespécie que ocorre no sul do Brasil é listada como least concern e vulnerável nas listas de espécies ameaçadas da IUCN e do Ministério do Meio Ambiente brasileiro, respectivamente. Em áreas nas quais a onça-pintada (Panthera onca) foi localmente extinta, o leão-baio tem o papel de predador de topo de cadeia alimentar influenciando na manutenção de processos do ecossistema e na...

  4. Effect of platelet inhibition with cangrelor during PCI on ischemic events.

    Science.gov (United States)

    Bhatt, Deepak L; Stone, Gregg W; Mahaffey, Kenneth W; Gibson, C Michael; Steg, P Gabriel; Hamm, Christian W; Price, Matthew J; Leonardi, Sergio; Gallup, Dianne; Bramucci, Ezio; Radke, Peter W; Widimský, Petr; Tousek, Frantisek; Tauth, Jeffrey; Spriggs, Douglas; McLaurin, Brent T; Angiolillo, Dominick J; Généreux, Philippe; Liu, Tiepu; Prats, Jayne; Todd, Meredith; Skerjanec, Simona; White, Harvey D; Harrington, Robert A

    2013-04-04

    The intensity of antiplatelet therapy during percutaneous coronary intervention (PCI) is an important determinant of PCI-related ischemic complications. Cangrelor is a potent intravenous adenosine diphosphate (ADP)-receptor antagonist that acts rapidly and has quickly reversible effects. In a double-blind, placebo-controlled trial, we randomly assigned 11,145 patients who were undergoing either urgent or elective PCI and were receiving guideline-recommended therapy to receive a bolus and infusion of cangrelor or to receive a loading dose of 600 mg or 300 mg of clopidogrel. The primary efficacy end point was a composite of death, myocardial infarction, ischemia-driven revascularization, or stent thrombosis at 48 hours after randomization; the key secondary end point was stent thrombosis at 48 hours. The primary safety end point was severe bleeding at 48 hours. The rate of the primary efficacy end point was 4.7% in the cangrelor group and 5.9% in the clopidogrel group (adjusted odds ratio with cangrelor, 0.78; 95% confidence interval [CI], 0.66 to 0.93; P=0.005). The rate of the primary safety end point was 0.16% in the cangrelor group and 0.11% in the clopidogrel group (odds ratio, 1.50; 95% CI, 0.53 to 4.22; P=0.44). Stent thrombosis developed in 0.8% of the patients in the cangrelor group and in 1.4% in the clopidogrel group (odds ratio, 0.62; 95% CI, 0.43 to 0.90; P=0.01). The rates of adverse events related to the study treatment were low in both groups, though transient dyspnea occurred significantly more frequently with cangrelor than with clopidogrel (1.2% vs. 0.3%). The benefit from cangrelor with respect to the primary end point was consistent across multiple prespecified subgroups. Cangrelor significantly reduced the rate of ischemic events, including stent thrombosis, during PCI, with no significant increase in severe bleeding. (Funded by the Medicines Company; CHAMPION PHOENIX ClinicalTrials.gov number, NCT01156571.).

  5. Le charme slave

    Directory of Open Access Journals (Sweden)

    Antonella Mauri

    2012-09-01

    Full Text Available Antonella Mauri analyse l’image des femmes slaves immigrées en Italie telle qu’elle apparaît à travers la publicité, la littérature romanesque (La ballata dei lavavetri de Peter Del monte, Luce Profuga de Valerio Aiolli, Pornokiller de Bruno Ventavoli, le cinéma, la bande dessinée (Danilo Maramotti, image qu’elle oppose aux résultats d’une enquête qu’elle a menée sur le terrain. Elle s’interroge en particulier sur la permanence des stéréotypes liés à la femme slave.

  6. Assessments of whole body scan images (PCI) obtained in patients undergoing treatment of radioiodine (pre and post-treatment)

    International Nuclear Information System (INIS)

    Costa, Fernanda Karolina Mendonca da; Lopes Filho, Ferdinand de Jesus; Vieira, Jose Wilson; Souza, Milena Thays Barbosa de

    2014-01-01

    Nuclear medicine is a medical specialty used for diagnosis and therapy of some diseases. For the treatment of differentiated thyroid carcinoma (papillary and follicular) Radioiodine therapy is employed, in order to eliminate the rest of thyroid tissue after removal of the thyroid (thyroidectomy). In radioiodine therapy is used radioisotope iodine-131 ( 131 I) as Sodium Iodide (NaI). The amount of the activity (dose) of 131 I administered is generally the responsibility of nuclear medicine, which is based on an image Research Length of the patient (pre-dose therapy PCI). PCI is also used after treatment (post-PCI therapeutic dose) to evaluate possible metastasis. The purpose of this study was to investigate the distribution of biokinetic 131 I at length and in some organs of the patient, in order to note any similarity. Exams PCI pre-dose and post-dose were analyzed, the anterior and posterior projections of ten patients. Contours in these images (ROI - Region Of Interest) were made in the whole body and in areas with high uptake of 131 I. The total score was used in the calculation to obtain the percentage distribution of 13I in the organs of the patient. The results showed that there similarity on the biodistribution of 131 I between pre-dose and post-dose PCI. Therefore, it was found that it is valuable images of PCI pre-dose therapy as a way to assist the nuclear medicine physician in choosing the best activity to be administered to the patient in order to minimize the dose to adjacent organs. (author)

  7. Influence of minor deterioration of renal function after PCI on outcome in patients with ST-elevation myocardial infarction.

    Science.gov (United States)

    Kanic, Vojko; Suran, David; Vollrath, Maja; Tapajner, Alojz; Kompara, Gregor

    2017-10-01

    Our aim was to assess the possible impact of a deterioration of renal function (DRF) not fulfilling the criteria for acute kidney injury after percutaneous coronary intervention (PCI) on outcome in patients with ST-elevation myocardial infarction (STEMI) on 30-day and long-term outcomes. Data is lacking on the influence of DRF after PCI on outcome in patients with STEMI. The present study is an analysis of 2572 STEMI patients who underwent PCI. The group with DRF (1022 patients) and the group without DRF (1550 patients) were compared. Thirty-day and long-term all-cause mortality were observed. Data was analyzed using descriptive statistics. Similar mortality was observed in both groups at day 30 (4.2% patients with DRF died vs 3.2% without DRF; ns) but more patients had died in the DRF group (18.9% patients with DRF vs 14.0% without DRF; P = 0.001) by the end of the observation period. After adjustments, DRF did not independently predict long-term mortality. Age more than 70 years, bleeding, hyperlipidemia, renal dysfunction on admission, anemia on admission, diabetes, PCI of LAD, the use of more than 200 mL contrast, but not DRF after PCI, were identified as independent prognostic factors for increased long-term mortality. Renal dysfunction, bleeding, contrast >200 mL, hyperlipidemia, age >70 years, anemia, and PCI LAD predicted DRF. DRF identified patients at increased risk of higher long-term mortality but was not independently associated with mortality. © 2017, Wiley Periodicals, Inc.

  8. Rapport financier trimestriel pour le trimestre qui a pris fin le 31

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    31 déc. 2016 ... Le CRDI finance des travaux de recherche appliquée ... développement international (le Centre) et lʼévolution de la ...... voie de développement et sur la mise en oeuvre des connaissances scientifiques, techniques et autres en vue du .... vertu d'accords de contribution conclus avec des bailleurs de fonds.

  9. LabVIEW Interface for PCI-SpaceWire Interface Card

    Science.gov (United States)

    Lux, James; Loya, Frank; Bachmann, Alex

    2005-01-01

    This software provides a LabView interface to the NT drivers for the PCISpaceWire card, which is a peripheral component interface (PCI) bus interface that conforms to the IEEE-1355/ SpaceWire standard. As SpaceWire grows in popularity, the ability to use SpaceWire links within LabVIEW will be important to electronic ground support equipment vendors. In addition, there is a need for a high-level LabVIEW interface to the low-level device- driver software supplied with the card. The LabVIEW virtual instrument (VI) provides graphical interfaces to support all (1) SpaceWire link functions, including message handling and routing; (2) monitoring as a passive tap using specialized hardware; and (3) low-level access to satellite mission-control subsystem functions. The software is supplied in a zip file that contains LabVIEW VI files, which provide various functions of the PCI-SpaceWire card, as well as higher-link-level functions. The VIs are suitably named according to the matching function names in the driver manual. A number of test programs also are provided to exercise various functions.

  10. Le e-commerce, facteur d’atténuation des iniquités territoriales en termes d’offre commerciale ?

    Directory of Open Access Journals (Sweden)

    Lucie Sieys

    2016-10-01

    Full Text Available Le e-commerce est un outil récent qui offre à tout un chacun la possibilité de vendre et d’acheter sur une plateforme virtuelle des biens et des services de toutes sortes. Il possède donc, en théorie, le potentiel de pallier les disparités spatiales d’accessibilité au commerce, qui peuvent être observées entre urbain, périurbain et rural. Notre article se propose d’analyser la façon dont le e-commerce est utilisé dans les différents types de territoires : nous mettons en évidence une similarité dans les pratiques des ménages, quel que soit leur territoire de résidence. Nous interprétons ces similarités par des pratiques de mobilité faciles (rapides et peu chères qui permettent aujourd’hui à une majeure partie des ménages un accès aux commerces traditionnels.

  11. Juego, representación y aprendizaje: Un taller de teatro para alumnos de E/LE

    Directory of Open Access Journals (Sweden)

    Leyre Goitia Pastor

    2012-08-01

    Full Text Available El objetivo de esta presentación es reflexionar sobre una  experiencia didáctica con alumnos de español como lengua  extranjera (E/LE de EE.UU., en el marco de un taller de teatro.

  12. PERFORMANCE ET RESTRUCTURATION: LE CAS SAÏDAL ...

    African Journals Online (AJOL)

    performance de SAÏDAL suite à sa restructuration débutée en 1997. Le concept de ... millions d'actions. Du point de vue du management, SAÏDAL adopte le tableau de .... Méthodes et Pratiques de la Performance : Le Guide du Pilotage. ... performance des entreprises, Kaplan et Norton proposèrent le tableau de bord ...

  13. A counting-card circuit based on PCI bus

    International Nuclear Information System (INIS)

    Shi Jing; Li Yong; Chinese Academy of Sciences, Lanzhou; Su Hong; Dong Chengfu; Li Xiaogang; Ma Xiaoli

    2004-01-01

    A counting-card circuit based on PCI bus that we developed recently used for advanced personal computer will be introduced in this paper briefly. The maximum count capacity of this counting-card is 10 9 -1, ranging from 0 to 999 999 999, the maximum counting time range, 1 x 10 6 s, can be set in 1 cycle, the maximum counting rate is 20 MHz for positive input. (authors)

  14. The Practice Pattern of Percutaneous Coronary Intervention in Korea: Based on Year 2014 Cohort of Korean Percutaneous Coronary Intervention (K-PCI) Registry.

    Science.gov (United States)

    Gwon, Hyeon-Cheol; Jeon, Dong Woon; Kang, Hyun-Jae; Jang, Jae-Sik; Park, Duk-Woo; Shin, Dong-Ho; Moon, Keon-Woong; Kim, Jung-Sun; Kim, Juhan; Bae, Jang-Whan; Hur, Seung-Ho; Kim, Byung Ok; Choi, Donghoon; Han, Kyoo-Rok; Kim, Hyo-Soo

    2017-05-01

    Appropriate use criteria (AUC) was developed to improve the quality of percutaneous coronary intervention (PCI). However, these criteria should consider the current practice pattern in the country where they are being applied. The algorithm for the Korean PCI practice pattern (KP3) was developed by modifying the United States-derived AUC in expert consensus meetings. KP3 class A was defined as any strategy with evidence from randomized trials that was more conservative for PCI than medical therapy or coronary artery bypass graft (CABG). Class C was defined as any strategy with less evidence from randomized trials and more aggressive for PCI than medical therapy or CABG. Class B was defined as a strategy that was partly class A and partly class C. We applied the KP3 classification system to the Korean PCI registry. The KP3 class A was noted in 67.7% of patients, class B in 28.8%, and class C in 3.5%. The median proportion of class C cases per center was 2.0%. The distribution of KP3 classes varied significantly depending on clinical and angiographic characteristics. The proportion of KP3 class C cases per center was not significantly dependent on PCI volume, but rather on the percentage of ACS cases in each center. We report the current PCI practice pattern by applying the new KP3 classification in a nationwide PCI registry. The results should be interpreted carefully with due regard for the complex relationships between the determining variables and the healthcare system in Korea.

  15. Une approche écosanté pour le contrôle de la fièvre de la vallée du ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 août 2016 ... La fièvre de la vallée du Rift est une maladie grave qui se transmet par la piqûre d'un moustique qui infecte l'être humain, le bétail et les animaux sauvages. De plus, les êtres humains peuvent contracter la maladie par tout contact avec des animaux infectés. La maladie s'est répandue dans toute l'Afrique ...

  16. Risk prediction models for major adverse cardiac event (MACE) following percutaneous coronary intervention (PCI): A review

    Science.gov (United States)

    Manan, Norhafizah A.; Abidin, Basir

    2015-02-01

    Five percent of patients who went through Percutaneous Coronary Intervention (PCI) experienced Major Adverse Cardiac Events (MACE) after PCI procedure. Risk prediction of MACE following a PCI procedure therefore is helpful. This work describes a review of such prediction models currently in use. Literature search was done on PubMed and SCOPUS database. Thirty literatures were found but only 4 studies were chosen based on the data used, design, and outcome of the study. Particular emphasis was given and commented on the study design, population, sample size, modeling method, predictors, outcomes, discrimination and calibration of the model. All the models had acceptable discrimination ability (C-statistics >0.7) and good calibration (Hosmer-Lameshow P-value >0.05). Most common model used was multivariate logistic regression and most popular predictor was age.

  17. The association between type D personality, and depression and anxiety ten years after PCI.

    Science.gov (United States)

    Al-Qezweny, M N A; Utens, E M W J; Dulfer, K; Hazemeijer, B A F; van Geuns, R-J; Daemen, J; van Domburg, R

    2016-09-01

    There are indications that type D personality and depression are associated in patients treated with percutaneous coronary intervention (PCI). However, at present it is unclear whether this relationship holds in the long term. This study's aim was to investigate the association between type D personality at 6 months post-PCI (baseline), and depression at 10-year follow-up. A secondary aim was to test the association between type D personality at baseline and anxiety at 10-year follow-up. A cohort of surviving consecutive patients (N = 534) who underwent PCI between October 2001 and October 2002. Patients completed the type D personality scale (DS14) measuring type D personality at baseline, and the Hospital Anxiety and Depression Scale (HADS) measuring anxiety and depression at baseline and at 10 years post-PCI. At baseline, the prevalence of type D personality was 25 % (135/534). Type D personality patients were more often depressed (42 %) than non-type D personality patients (9 %). Response rate of anxiety and depression questionnaires at 10 years was 75 %. At 10-year follow-up, 31 % of type D personality patients were depressed versus 13 % of non-type D personality patients. After adjustments, baseline type D personality remained independently associated with depression at 10 years (OR = 3.69; 95 % CI [1.89-7.19]). Type D showed a similar association with anxiety at 10 years, albeit somewhat lower (OR = 2.72; 95 % CI [1.31-5.63]). PCI patients with type D personality had a 3.69-fold increased risk for depression and a 2.72-fold increased risk for anxiety at 10 years of follow-up.

  18. Le paysage anglais: du jardin à la campagne

    Directory of Open Access Journals (Sweden)

    Gilly LEHMANN

    1987-12-01

    Full Text Available Lele des jardins dans le paysage anglais tient tout autant à ce qui se passe dans les esprits qu'aux réalités concrètes. L'apogée dans la création des jardins et des parcs influant sur le paysage campagnard a lieu au 18e siècle. Les créateurs d'alors visent à construire un paysage idéal; les périodes suivantes proposeront aussi les leurs.

  19. Le paludisme, le tsunami silencieux d'Afrique | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 janv. 2011 ... Dans un élan de compassion fort justifié, le monde s'est porté au secours des victimes du tsunami qui a touché récemment la région de l'océan Indien. Mais il ignore qu'un « tsunami silencieux », le paludisme, s'abat sans cesse sur l'Afrique et y fait chaque année plus de 1,5 million de victimes, surtout de ...

  20. Le stéréorestituteur Kelsh

    Science.gov (United States)

    Kelsh, H.T.

    1949-01-01

    Le ste??re??orestituteur Kelsh est un appareil de restitution a?? double projection base?? sur le principe des anaglyphes, comme le Multiplex par exemple, mais il a une plus grande pre??cision que ce dernier, vu que les ne??gatifs sont utilise??s directement pour la restitution, sans que l'on soit oblige?? de les re??duire au pre??alable. Une telle solution devient possible lorsque l'e??chelle de l'image plastique (mode??le) est au moins 7 fois plus grande que celle des cliche??s. L'appareil comprend un support reposant par 4 pieds sur la table a?? dessin. Sa partie supe??rieure porte, par l'interme??diaire de trois vis calantes, un cadre dans lequel les deux chambres de projection sont suspendues. Des leviers de commande, agissant sur les chambres, permettent d'introduire la base, le de??versement et les inclinaisons transversale et longitudinale. Les cliche??s conjugue??s ou des diapositifs sont directement place??s dans les chambres de projection munies d'objectifs. En projetant les deux cliche??s au moyen de couleurs comple??mentaires, l'observateur - muni de lunettes a?? verres colore??s (couleurs comple??mentaires) - observe l'image plastique audessus de la table a?? dessin, l'orientation relative des chambres ayant e??te?? e??tablie au pre??alable. Pour le report des points de l'image plastique sur la minute, l'ope??rateur dispose d'une tablette amovible a?? marque-repe??re lumineuse qu'il de??place a?? la main et dont la hauteur au-dessus de la table a?? dessin peut e??tre commande??e par une molette. Pour e??tablir l'orientation absolue de l'image plastique, il suffit d'incliner convenablement le cadre de suspension a?? l'aide des vis calantes, l'orientation relative n'e??tant pas de??truite par cette ope??ration. Les deux cliche??s sont e??claire??s par des projecteurs munis d'une suspension a?? la cardan et relie??s a?? la tablette de restitution par des tiges te??lescopiques. Moyennant ce dispositif, l'e??clairage est concentre?? sur deux petites re

  1. Infection par le VIH chez les patientes atteintes de cancer du sein en Guinée (Afrique de l'Ouest)

    Science.gov (United States)

    Traore, Bangaly; Diane, Solomana; Sow, Mamadou Saliou; Keita, Mamady; Conde, Mamoudou; Traore, Fodé Amara; Kourouma, Tidiane

    2015-01-01

    L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les dossiers de patientes atteintes de cancers du sein histologiquement confirmés, infectées ou non par le VIH à l'unité de chirurgie oncologique de Donka, CHU de Conakry, de 2007 à 2012. Nous avons colligé 278 patientes présentant un cancer du sein dont 14 (5,0%) infectées par le VIH et 264 (95,0%) non infectées par le VIH. Les différences observées entre ces deux groupes de patientes étaient respectivement: âge médian (36,8 vs 49,0 ans), la ménopause (21,4% vs 53,4%), le nombre des patientes traitées (50,0% contre 77,1%) et la survenue de décès (78,6% vs 50,8%). Aucune différence n'a été notée dans la présentation clinique, histologique et le retard de consultation. Dans notre étude, la prévalence de l'infection à VIH chez les patients atteints de cancer du sein est élevée. L’âge jeune des patients, la faible accessibilité au traitement et la mortalité élevée doivent être confirmés par une étude sur un échantillon plus large. PMID:26523196

  2. Le paradigme du Mur dans le monde contemporain : évolution et perspectives 1989-2009

    Directory of Open Access Journals (Sweden)

    Hélène Yèche

    2010-06-01

    Full Text Available Il y a près de vingt ans, dans la nuit du 9 au 10 novembre 1989, disparaissait le mur de Berlin, symbole de la séparation de l’Europe en deux blocs antagonistes – d’un côté le camp soviétique, de l’autre le camp occidental. Le véritable tournant de ce que l’on a ensuite appelé la « révolution pacifique » eut cependant lieu un mois auparavant, le 9 octobre 1989, avec la première manifestation de masse qui réunit environ 70 000 personnes à Leipzig, RDA (ville plus tard honorée du titre de Helde...

  3. Les enjeux du modèle standard

    CERN Document Server

    CERN. Geneva

    2008-01-01

    Toute la matière visible dans l'Univers est décrite par le « Modèle Standard ». Selon cette théorie, la matière est constituée d'atomes, qui contiennent des électrons orbitant autour de noyaux, dont les composants fondamentaux sont les quarks. Quatre forces fondamentales agissent entre ces particules élémentaires : les forces électromagnétique est gravitationnelle, et les interactions nucléaires forte et faible. La description fournie par le Modèle Standard de ces particules et de leurs interactions est en parfait accord avec les expériences. Néanmoins, des questions fondamentales restent sans réponse jusqu'à maintenant : d'où vient la masse des particules ? Pourquoi y a-t-il tant de types de particules ? Existe-t-il une théorie unifiée de toutes les interactions ? Quelle est la nature de la matière cachée prédite par les astrophysiciens ? Le LHC au CERN donnera des éléments de réponse à ces questions au-delà du Modèle Standard.

  4. Le CERN ouvre ses entrailles au public

    CERN Multimedia

    2004-01-01

    "Le CERN se lance dans une grande opération de relations publiques pour son cinquantième anniversaire. Le centre de recherche organisera une journée portes ouvertes le 16 octobre. Quelque 50 sites pourrant être visités" (1/2 page)

  5. Le Associazioni delle donne e i diritti dell’infanzia in Italia (1861-1930

    Directory of Open Access Journals (Sweden)

    Gabriella Seveso

    2017-12-01

    Full Text Available Lo scopo di questo articolo è quello di presentare la diffusione delle istituzioni educative per i bambini piccoli italiani e il modo in cui è significativamente legato alle associazioni femministe e alle iniziative di pensatori e pensatori illuminati. L'articolo ricostruisce la storia del diritto all'educazione per la prima infanzia in Italia nel periodo tra l'Unità d'Italia (1861 e i primi decenni del XX secolo. Rivela come queste iniziative hanno sottolineato la necessità di fornire istituzioni educative per giovani ragazze e bambini, non solo a fini di cura o igiene; ma spesso con importanti principi educativi come l'attenzione agli spazi, i rapporti con le famiglie e altri. L'articolo sottolinea anche come l'associazione femminista abbia anche combattuto duramente per un'adeguata formazione professionale di insegnanti e insegnanti.

  6. Ecrivains français de Page classique proposés pour l'enseignement du F.LE. en Espagne aux 18e et 19e siècles

    OpenAIRE

    Fischer Hubert, Denise

    2015-01-01

    L'étude de la littérature dans les manuels de FLE est assez tardive. L'accent est surtout mis, aux 17e et 18° siècles, sur les règles de grammaire, de prononciation et aussi sur le «français fonctionnel» (dialogues utiles aux marchands et voyageurs qui se déplacent en France et ont besoin d'une phraséologie courante). A la fin du 18e et au 19e siècle, on commence à penser que la lecture des grands classiques est un point important dans l'étude de la langue. Le grammairien se réfère sans cesse...

  7. Assessment of VME-PCI Interfaces with Linux Drivers

    CERN Document Server

    Schossmater, K; CERN. Geneva

    2000-01-01

    Abstract This report summarises the performance measurements and experiences recorded by testing three commercial VME-PCI interfaces with their Linux drivers. These interfaces are manufactured by Wiener, National Instruments and SBS Bit 3. The developed C programs are reading/writing a VME memory in different transfer modes via these interfaces. A dual processor HP Kayak XA-s workstation was used with the CERN certified Red Hat Linux 6.1 running on it.

  8. Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.

    Science.gov (United States)

    Cannon, Christopher P; Bhatt, Deepak L; Oldgren, Jonas; Lip, Gregory Y H; Ellis, Stephen G; Kimura, Takeshi; Maeng, Michael; Merkely, Bela; Zeymer, Uwe; Gropper, Savion; Nordaby, Matias; Kleine, Eva; Harper, Ruth; Manassie, Jenny; Januzzi, James L; Ten Berg, Jurrien M; Steg, P Gabriel; Hohnloser, Stefan H

    2017-10-19

    Triple antithrombotic therapy with warfarin plus two antiplatelet agents is the standard of care after percutaneous coronary intervention (PCI) for patients with atrial fibrillation, but this therapy is associated with a high risk of bleeding. In this multicenter trial, we randomly assigned 2725 patients with atrial fibrillation who had undergone PCI to triple therapy with warfarin plus a P2Y 12 inhibitor (clopidogrel or ticagrelor) and aspirin (for 1 to 3 months) (triple-therapy group) or dual therapy with dabigatran (110 mg or 150 mg twice daily) plus a P2Y 12 inhibitor (clopidogrel or ticagrelor) and no aspirin (110-mg and 150-mg dual-therapy groups). Outside the United States, elderly patients (≥80 years of age; ≥70 years of age in Japan) were randomly assigned to the 110-mg dual-therapy group or the triple-therapy group. The primary end point was a major or clinically relevant nonmajor bleeding event during follow-up (mean follow-up, 14 months). The trial also tested for the noninferiority of dual therapy with dabigatran (both doses combined) to triple therapy with warfarin with respect to the incidence of a composite efficacy end point of thromboembolic events (myocardial infarction, stroke, or systemic embolism), death, or unplanned revascularization. The incidence of the primary end point was 15.4% in the 110-mg dual-therapy group as compared with 26.9% in the triple-therapy group (hazard ratio, 0.52; 95% confidence interval [CI], 0.42 to 0.63; Pdual-therapy group as compared with 25.7% in the corresponding triple-therapy group, which did not include elderly patients outside the United States (hazard ratio, 0.72; 95% CI, 0.58 to 0.88; Pdual-therapy groups combined as compared with 13.4% in the triple-therapy group (hazard ratio, 1.04; 95% CI, 0.84 to 1.29; P=0.005 for noninferiority). The rate of serious adverse events did not differ significantly among the groups. Among patients with atrial fibrillation who had undergone PCI, the risk of bleeding was

  9. Combattre le jaunissement mortel du cocotier (FCRSAI 2e phase ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Elle a eu des répercussions néfastes sur le revenu des agriculteurs et sur la nutrition des familles des régions côtières, et menace de s'étendre ... Le projet vise à renforcer les capacités de recherche locales en ce qui concerne : ... Site internet.

  10. "PCI Reading Program": The Final Report of a Three Year Experimental Study in Brevard Public Schools and Miami-Dade County Public Schools. Research Report

    Science.gov (United States)

    Toby, Megan; Jaciw, Andrew; Ma, Boya; Lipton, Akiko

    2011-01-01

    PCI Education conducted a three-year longitudinal study to determine the comparative effectiveness of the "PCI Reading Program" ("PCI") for students with severe disabilities as implemented in Florida's Brevard Public Schools and Miami-Dade County Public Schools. The primary question addressed by the study is whether students…

  11. Control of radioactive contamination of food in the country Somogy

    International Nuclear Information System (INIS)

    Varga, E.; Viragh, I.

    1980-01-01

    The radioactive contamination of spinach, sorrel, lettuce, animal bones, milk and fish was determined in the period 1961-1978. Peak values were measured in 1963 and 1976. The contamination of plants reached higher levels, however, it did not exceed 25 pCi per g dry weight. (L.E.)

  12. The Road Pavement Condition Index (PCI Evaluation and Maintenance: A Case Study of Yemen

    Directory of Open Access Journals (Sweden)

    Karim Fareed M. A.

    2016-12-01

    Full Text Available The pavement condition index (PCI is a simple, convenient and inexpensive way to monitor the condition of the surface of roads, identify maintenance and rehabilitation (M-and-R needs as well as ensure that road maintenance budgets are spent wisely. In this research, the pavement condition was evaluated in terms of the surface distresses existing at the time of the field evaluation. The PCI procedure was used in this research because it deals with the subject of pavement distress identification most comprehensively and is based on a sound statistical technique of pavement sampling.

  13. trans-[Pt(BCat')Me(PCy3)2]: an experimental case study of reductive elimination processes in Pt-Boryls through associative mechanisms.

    Science.gov (United States)

    Braunschweig, Holger; Bertermann, Rüdiger; Brenner, Peter; Burzler, Michael; Dewhurst, Rian D; Radacki, Krzysztof; Seeler, Fabian

    2011-10-10

    A stable trans-(alkyl)(boryl) platinum complex trans-[Pt(BCat')Me(PCy(3))(2)] (Cat'=Cat-4-tBu; Cy=cyclohexyl=C(6)H(11)) was synthesised by salt metathesis reaction of trans-[Pt(BCat')Br(PCy(3))(2)] with LiMe and was fully characterised. Investigation of the reactivity of the title compound showed complete reductive elimination of Cat'BMe at 80 °C within four weeks. This process may be accelerated by the addition of a variety of alkynes, thereby leading to the formation of the corresponding η(2) -alkyne platinum complexes, of which [Pt(η(2)-MeCCMe)(PCy(3))(2)] was characterised by X-ray crystallography. Conversion of the trans-configured title compound to a cis derivative remained unsuccessful due to an instantaneous reductive elimination process during the reaction with chelating phosphines. Treatment of trans-[Pt(BCat')Me(PCy(3))(2)] with Cat(2)B(2) led to the formation of CatBMe and Cat'BMe. In the course of further investigations into this reaction, indications for two indistinguishable reaction mechanisms were found: 1) associative formation of a six-coordinate platinum centre prior to reductive elimination and 2) σ-bond metathesis of B-B and C-Pt bonds. Mechanism 1 provides a straightforward explanation for the formation of both methylboranes. Scrambling of diboranes(4) Cat(2)B(2) and Cat'(2)B(2) in the presence of [Pt(PCy(3))(2)], fully reductive elimination of CatBMe or Cat'BMe from trans-[Pt(BCat')Me(PCy(3))(2)] in the presence of sub-stoichiometric amounts of Cat(2)B(2), and evidence for the reversibility of the oxidative addition of Cat(2)B(2) to [Pt(PCy(3))(2)] all support mechanism 2, which consists of sequential equilibria reactions. Furthermore, the solid-state molecular structure of cis-[Pt(BCat)(2)(PCy(3))(2)] and cis-[Pt(BCat')(2)(PCy(3))(2)] were investigated. The remarkably short B-B separations in both bis(boryl) complexes suggest that the two boryl ligands in each case are more loosely bound to the Pt(II) centre than in related bis

  14. Lowering risk score profile during PCI in multiple vessel disease is associated with low adverse events: The ERACI risk score.

    Science.gov (United States)

    Rodriguez, Alfredo E; Fernandez-Pereira, Carlos; Mieres, Juan; Pavlovsky, Hernan; Del Pozo, Juan; Rodriguez-Granillo, Alfredo M; Antoniucci, David

    2018-02-13

    In recent years angiographic risk scores have been introduced in clinical practice to stratify different levels of risk after percutaneous coronary interventions (PCI). The SYNTAX score included all intermediate lesions in vessels ≥1.5 mm, consequently, multiple stent implantation was required. Four years ago, we built a new angiographic score in order to guide PCI strategy avoiding stent deployment both in intermediate stenosis as in small vessels, therefore these were not scored (ERACI risk score). The purpose of this mini review is to validate the strategy of PCI guided by this scoring, taking into account long term follow up outcomes of two observational and prospective registries where this policy was used. With this new risk score we have modified risk profile of our patient's candidates for PCI or coronary artery bypass surgery lowering the risk and PCI. The simple exclusion of small vessels and intermediate stenosis from the revascularization approach resulted in clinical outcome comparable with the one of fractional flow reserve guided revascularization. Low events rate at late follow up observed in both studies was also in agreement with guided PCI by functional lesion assessment observed by Syntax II registry, where investigators found lower events rate in spite of a few number of stents implanted per patient. use of ERACI risk scores may significantly reclassify patients into a lower risk category and be associated with low adverse events rate. Copyright © 2018. Published by Elsevier Inc.

  15. Terre-Neuve ou la carte éclatée d'après le «Grand Insulaire» d'André Thevet

    Directory of Open Access Journals (Sweden)

    Frank LESTRINGANT

    1987-09-01

    Full Text Available Les deux cartes relatives à Terre-Neuve, représentée comme un archipel, que l'on trouve dans le Grand Insulaire inachevé du cosmographe André Thevet (circa, 1586, sont un bon témoignage des errements en partie calculés auxquels se prêtait la cartographie à l'époque des Grandes Découvertes. Pour vaincre des contraintes techniques d'une part, telles que la nécessité du montage entre des données disparates, et pour affirmer d'autre part le dessein d'une entreprise de conquête, le cosmographe — ou géographe universel — est amené à truquer, selon les règles de l'art, un document composite, prélevé à l'origine sur le planisphère de Mercator et augmenté d'informations venues des routiers portulans. Une île inédite, qui porte le nom de Thevet, a pour fonction de signer le tout.

  16. Use and impact of thrombectomy in primary percutaneous coronary intervention for acute myocardial infarction with persistent ST-segment elevation: results of the prospective ALKK PCI-registry.

    Science.gov (United States)

    Härle, Tobias; Zeymer, Uwe; Hochadel, Matthias; Schmidt, Karin; Zahn, Ralf; Darius, Harald; Behrens, Steffen; Lauer, Bernward; Mudra, Harald; Schächinger, Volker; Elsässer, Albrecht

    2015-10-01

    Data about the impact of thrombectomy in primary percutaneous coronary intervention (PCI) are inconsistent. The aim of our study was an evaluation of both the real-world use of thrombectomy and the impact of thrombectomy on outcome in unselected patients treated with primary PCI for ST-elevation myocardial infarction (STEMI). We used the data of the prospective ALKK PCI-registry of 35 hospitals from January 2010 to December 2013. A total of 10,755 patients receiving single-vessel primary PCI for acute STEMI were included. In 2176 patients (20.2 %) thrombectomy was performed. There was a wide range of use of thrombectomy in the different ALKK hospitals from 1.1 to 61.7 % (median 18.6 %, quartiles 6.0 and 40.3 %) with a general increase of use over the first years of the study period. In patients with and without thrombectomy there was TIMI 0 flow present before PCI in 6010 patients, TIMI 1 in 1338, TIMI 2 in 2002, and TIMI 3 in 1405. Patients with acute heart failure or cardiogenic shock received significantly more often thrombectomy. Fluoroscopy time (8.1 vs. 7.3 min, p PCI had significantly higher rates of TIMI 3 flow after PCI when treated with thrombectomy (87.1 vs. 84.1 %, p PCI TIMI 3 flow in patients with TIMI 1, 2 or 3 flow before PCI. Rates of major adverse cardiac and cerebrovascular events were similar in both groups in general and in all subgroups of TIMI flow. The use of thrombectomy in patients with STEMI is heterogenous between hospitals. Overall, there was no impact of thrombectomy on TIMI 3 patency or mortality after PCI. In the subgroup of STEMI patients with TIMI 0 flow before PCI individualized thrombectomy had a positive impact on restoration of normal blood flow.

  17. Le genre comme rapport d’inégalité sociale dans le discours publicitaire

    Directory of Open Access Journals (Sweden)

    Jean-Claude Soulages

    2016-12-01

    Full Text Available Loin de se réduire à une simple transaction commerciale, une annonce publicitaire est un espace de croyances sur des identités, des rôles et des pratiques sociales. Au même titre que d’autres productions fictionnelles de la culture de masse, elle représente l’une des faces de ce miroir social alimenté par la circulation incessante d’attitudes et de croyances, affichant même s’il s’agit bien souvent pour cette dernière d’un positionnement ludique, un second monde peuplé par nos avatars. La publicité tout comme le fait la fiction télévisée définit l’horizon des possibles d’une communauté donnée. Ce qu’elles réalisent toutes deux c’est l’entrée de l’imaginaire dans le réel. Même si, à partir des années 70, s’opère un lent défigement des stéréotypes sexistes, le publicitaire ne se fera aucunement le porte-parole explicite d’une quelconque lutte féministe, il optera toujours pour une tactique ambivalente de double speak: des effets de décadrage mettant en exergue des situations délibérément décalées ou burlesques (Un homme qui change les couches de bébé! Un clown qui fait la lessive!, mais cristallisant des inégalités de rôles. En jouant tout à la fois sur le défigement et la réactivation des stéréotypes, c’est bien un rôle de passeur et de go between, qu’est assigné le publicitaire en se faisant l’arbitre ventriloque de ces conflits de légitimité et de construction identitaire qui agitent notre modernité.

  18. Long-term outcome of FFR-guided PCI for stable coronary artery disease in daily clinical practice

    DEFF Research Database (Denmark)

    De Backer, Ole; Biasco, Luigi; Lønborg, Jacob

    2016-01-01

    AIMS: Our aim was to investigate the strength of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) in daily practice. METHODS AND RESULTS: For this study, 3,512 patients with stable CAD and at least one 50-89% coronary stenosis...... were identified; those patients thought to require PCI (n=1,716) were selected. Of these, 962 (56%) were treated based on angiography (XA) alone, whereas 754 patients (44%) had an FFR-guided treatment. In the latter group, 321 patients (43%) were reallocated to another treatment, predominantly medical...... treatment. After propensity score matching, the number of indicated lesions was 957 in the XA-guided group and 947 in the FFR-guided group. FFR guidance resulted in PCI deferral in 462 lesions (48.8%). In a seven-day landmark analysis, the rate of periprocedural myocardial infarction (MI) was less than half...

  19. Effect of preoperative small dose of tirofiban on PCI treatment in patients with acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Li Wang

    2016-06-01

    Full Text Available Objective: To analyze the effect of preoperative small dose of tirofiban on PCI treatment prognosis in patients with acute coronary syndrome. Methods: A total of 108 cases with acute coronary syndrome who received PCI treatment in our hospital from August 2011 to May 2014 were included for study and randomly divided into observation group and control group by half according to different treatment methods. Control group received PCI treatment alone, observation group received small dose of tirofiban combined with PCI treatment, and then differences in hemorheology indicators, platelet function, left ventricular systolic function and left ventricular diastolic function parameters, serum indicators and so on were compared between two groups after treatment. Results: Whole blood high shear viscosity, whole blood low shear viscosity, reduced high shear viscosity, reduced low shear viscosity, plasma ratio viscosity, erythrocyte aggregation index and erythrocyte deformability index of observation group after treatment were all less than those of control group (P<0.05; PAdT, PAgT, CD62p, CD40L and P-selectin values of observation group after treatment were all lower than those of control group (P<0.05; LPER and LPFR values of observation group 1 week after treatment were higher than those of control group while LTPER and LTPFR values were lower than those of control group (P<0.05; serum GA, MCP-1, PAI-1, NT-proBNP, PAC-1, VCAM-1 and ICAM-1 values of observation group after treatment were all lower than those of control group (P<0.05. Conclusions: Small dose of tirofiban combined with PCI treatment for patients with acute coronary syndrome can effectively enhance therapeutic effect, inhibit platelet activity while protect heart function and optimize long-term treatment outcome.

  20. Taxes sur le tabac, contrebande et vendeurs de rue en Érythrée ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'Érythrée a pris des mesures pour lutter contre le tabagisme. Sa proclamation de 2004 ainsi que l'augmentation des taxes sur les cigarettes et les autres produits du tabac visent à réduire la consommation de tabac. Pourtant, la consommation augmente malgré ces mesures. La mise en oeuvre de la proclamation laisse à ...

  1. Les pôles de compétitivité : le recours au modèle des clusters ?

    Directory of Open Access Journals (Sweden)

    Jean Bouinot

    2007-03-01

    Full Text Available Introduction : définition d’un cluster En novembre 2004, le gouvernement a lancé un appel d’offre pour structurer des pôles de compétitivité que les praticiens français n’hésitent pas à qualifier de cluster, littéralement un rassemblement du type « bouquet de fleurs ». Pour une définition théorique on peut s’appuyer sur une comparaison avec le modèle du district industriel italien (MDII. Le district est spécialisé dans un produit donné (chaussures de sport à Montebelluna, le leader mondial e...

  2. Evaluation of changes in left ventricular structure and function in hypertensive patients with coronary artery disease after PCI using real-time three-dimensional echocardiography.

    Science.gov (United States)

    Meng, Yanhong; Zong, Ling; Zhang, Ziteng; Han, Youdong; Wang, Yanhui

    2018-02-01

    We aimed to evaluate the changes in left ventricular structure and function in hypertensive patients with coronary artery disease before and after percutaneous coronary intervention (PCI) using real-time three-dimensional echocardiography. Two hundred and eighty hypertensive patients with coronary artery disease undergoing PCI and 120 cases who did not receive PCI in our hospital were selected as the subjects of our study. All patients were administered with routine antiplatelet, anticoagulant, lipid-lowering, antihypertensive, dilating coronary artery and other medications. The left ventricular systolic function and systolic synchrony index changes before and after subjects were treated by PCI were analyzed using three-dimensional echocardiography. At 2 days before surgery, there were no significant differences in the left ventricular end-diastolic volume, left ventricular end-systolic volume (LVESV) and ejection fraction (EF) between the two patient groups (P>0.05). At 3 months and 9 months, the two key time points after PCI, the LVESV level in the PCI group was distinctly decreased, while EF was significantly increased (P0.05); however, the parameters of time from the corresponding segment of the myocardium to the minimal systolic volume in patients in the PCI group were significantly reduced at 3 and 9 months after surgery (PPCI accurately and in real-time, which may play a significant role.

  3. Outcomes of Middle Eastern Patients Undergoing Percutaneous Coronary Intervention: The Primary Analysis of the First Jordanian PCI Registry.

    Science.gov (United States)

    Alhaddad, Imad A; Tabbalat, Ramzi; Khader, Yousef; Al-Mousa, Eyas; Izraiq, Mahmoud; Nammas, Assem; Jarrah, Mohammad; Saleh, Akram; Hammoudeh, Ayman

    2017-01-01

    This is a prospective multicenter registry designed to evaluate the incidence of adverse cardiovascular events in Middle Eastern patients undergoing percutaneous coronary interventions (PCI). The registry was also designed to determine the predictors of poor outcomes in such patients. We enrolled 2426 consecutive patients who underwent PCI at 12 tertiary care centers in Jordan between January 2013 and February 2014. A case report form was used to record data prospectively at hospital admission, discharge, and 12 months of follow-up. Mean age was 56 ± 11 years, females comprised 21% of the study patients, 62% had hypertension, 53% were diabetics, and 57% were cigarette smokers. Most patients (77%) underwent PCI for acute coronary syndrome. In-hospital and 1-year mortality rates were 0.78% and 1.94%, respectively. Definite or probable stent thrombosis occurred in 9 patients (0.37%) during hospitalization and in 47 (1.94%) at 1 year. Rates of target vessel repeat PCI and coronary artery bypass graft surgery at 1 year were 3.4% and 0.6%, respectively. The multivariate analysis revealed that cardiogenic shock, congestive heart failure, ST-segment deviation, diabetes, and major bleeding were significantly associated with higher risk of 1-year mortality. In this first large Jordanian registry of Middle Eastern patients undergoing PCI, patients treated were relatively young age population with low in-hospital and 1-year adverse cardiovascular events. Certain clinical features were associated with worse outcomes and may warrant aggressive therapeutic strategies.

  4. Le piano touchant/touché: l'instrument du contretemps chez Gide, le cas du Journal et des Notes sur Chopin

    OpenAIRE

    Zorica Vukušić, Maja

    2011-01-01

    André Gide, romancier, essayiste, critique et traducteur, a été le diariste dont le journal (écrit de 1887 jusqu`à 1949) est imbibé de musique. Gide a aussi été pianiste – amateur (dans le sens barthésien du terme), tout comme Nietzsche, Sartre ou Barthes. Leur proximité nous est donnée dans une sorte de polémique imaginée qui dépasse le discours. Sans doute Adorno et Jankélévitch ont été meilleurs pianistes et meilleurs philosophes de la musique, mais Gide s`est éloigné de la ...

  5. Measurement of microvascular function in patients presenting with thrombolysis for ST elevation myocardial infarction, and PCI for non-ST elevation myocardial infarction.

    Science.gov (United States)

    Palmer, Sonny; Layland, Jamie; Adams, Heath; Ashokkumar, Srikkumar; Williams, Paul D; Judkins, Christopher; La Gerche, Andre; Burns, Andrew T; Whitbourn, Robert J; MacIsaac, Andrew I; Wilson, Andrew M

    2018-04-12

    In this prospective study, we compared the invasive measures of microvascular function in two subsets: patients with pharmacoinvasive thrombolysis for STEMI, and patients undergoing percutaneous coronary intervention (PCI) for NSTEMI. The study consisted of 17 patients with STEMI referred for cardiac catheterisation post thrombolysis, and 20 patients with NSTEMI. Coronary physiological indexes were measured in each patient before and after PCI. The median pre-PCI index of microcirculatory function (IMR) at baseline was significantly higher in the STEMI group than the NSTEMI group (26 units vs. 15 units, p = 0.02). Following PCI, IMR decreased in both groups (STEMI 20 units vs. NSTEMI 14 units, p = 0.10). There was an inverse correlation between post PCI IMR and left ventricular ejection fraction (LVEF) (r = -0.52, p = 0.001). Furthermore, post PCI IMR was an independent predictor of index admission LVEF in the total population (β = -0.388, p = 0.02). Invasive measures of microvascular function are inferior in a pharmacoinvasive STEMI group compared to a clinically stable NSTEMI group. In the STEMI population, the IMR following coronary intervention appears to predict LVEF. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. El microcuento en la clase de E/LE

    Directory of Open Access Journals (Sweden)

    Héctor Monteagudo Ballesteros

    2012-08-01

    Full Text Available El microcuento es una valiosa herramienta para que los estudiantes de nivel INTERMEDIO1 adquieran ya las estrategias de comprensión y producción de textos necesarias en niveles superiores. Su carácter escrito y finalidad estilística no resultan inconvenientes si desarrollamos  adecuadamente las virtudes de brevedad, linealidad, precisión y capacidad de síntesis en el aula; de hecho, se convertirán en nuestras aliadas, porque nos liberarán de la tiranía del contexto verosímil e  inmediato para explorar los entresijos del cotexto, los mecanismos de la coherencia interna y de aquellos elementos elididos a los que remiten los deícticos. También le proporcionará al estudiante una nueva forma de codificar no sólo lo que dice, sino lo que quiere decir, de forma parecida a cómo lo haría en su lengua materna.

  7. Le nom Škerlj dans le cadre des noms Slovenes actuels

    Directory of Open Access Journals (Sweden)

    Franc Jakopin

    1975-11-01

    Full Text Available L'auteur du présent article place le nom Škerlj dans le cadre des noms slovènes actuels qui ont la même constitution phonetique, en éliminant les noms qui, par leur répartition géographique, leurs fréquences et caractéristiques formales, n'entrent pas dans ce cadre. A l'origine du nom Škerlj (et de ses variantes entrent l'appelatif skril (Schiefer et la base d'une onomatopée populaire škrlj (alauda. Par l'énorme force de créer les noms propres de cette derniere nommée, on chercherait l'origine du nom Škerlj surtout dans celle-ci.

  8. Five-year outcomes of percutaneous versus surgical coronary revascularization in patients with diabetes mellitus (from the CREDO-Kyoto PCI/CABG Registry Cohort-2).

    Science.gov (United States)

    Marui, Akira; Kimura, Takeshi; Nishiwaki, Noboru; Mitsudo, Kazuaki; Komiya, Tatsuhiko; Hanyu, Michiya; Shiomi, Hiroki; Tanaka, Shiro; Sakata, Ryuzo

    2015-04-15

    We investigated the impact of diabetes mellitus on long-term outcomes of percutaneous coronary intervention (PCI) in the drug-eluting stent era versus coronary artery bypass grafting (CABG) in a real-world population with advanced coronary disease. We identified 3,982 patients with 3-vessel and/or left main disease of 15,939 patients with first coronary revascularization enrolled in the Coronary Revascularization Demonstrating Outcome Study in Kyoto PCI/CABG Registry Cohort-2 (patients without diabetes: n = 1,984 [PCI: n = 1,123 and CABG: n = 861], and patients with diabetes: n = 1,998 [PCI: n = 1,065 and CABG: n = 933]). Cumulative 5-year incidence of all-cause death after PCI was significantly higher than after CABG both in patients without and with diabetes (19.8% vs 16.2%, p = 0.01, and 22.9% vs 19.0%, p = 0.046, respectively). After adjusting confounders, the excess mortality risk of PCI relative to CABG was no longer significant (hazard ratio [HR] 1.16; 95% confidence interval [CI] 0.88 to 1.54; p = 0.29) in patients without diabetes, whereas it remained significant (HR 1.31; 95% CI 1.01 to 1.70; p = 0.04) in patients with diabetes. The excess adjusted risks of PCI relative to CABG for cardiac death, myocardial infarction (MI), and any coronary revascularization were significant in both patients without (HR 1.59, 95% CI 1.01 to 2.51, p = 0.047; HR 2.16, 95% CI 1.20 to 3.87, p = 0.01; and HR 3.30, 95% CI 2.55 to 4.25, p PCI relative to CABG for all-cause death, cardiac death, MI, and any revascularization. In conclusion, in both patients without and with diabetes with 3-vessel and/or left main disease, CABG compared with PCI was associated with better 5-year outcomes in terms of cardiac death, MI, and any coronary revascularization. There was no difference in the direction and magnitude of treatment effect of CABG relative to PCI regardless of diabetic status. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. La construction de la matière le modèle Standard

    CERN Document Server

    Léon, Jacques

    2016-01-01

    Qu'est-ce que la matière ? Voilà une question à laquelle il pourrait sembler facile de répondre car il n'est rien de plus concret que la matière. Et pourtant, la réponse qu'en donne la physique contemporaine est pour le moins déconcertante ! Le concept-même de particules, briques élémentaires de la matière, s'est volatilisé, dissout dans des objets mathématiques abstraits et abscons pour les non-initiés. Plus nos théories sont précises et plus l'image qu'elles nous renvoient est insaisissable. En un siècle, la représentation des particules s'est métamorphosée en nuages de probabilité portés par des champs quantiques régis par des symétries confinées dans des espaces abstraits. Mais dans un même temps, nous avons réussi le tour de force d'expliquer toute cette complexité avec seulement 16 particules… et une seule théorie, véritable construction de notre conception de la matière : le modèle standard. Ce livre tente de guider le lecteur dans le dédale de la physique des particu...

  10. Feelings of being disabled as a prognostic factor for mortality in men and women post-PCI up to 12 years

    NARCIS (Netherlands)

    Bergman, M.J.; Utens, E.M.W.J.; de Jager, T.A.J.; Radhoe, S.P.; Daemen, J.; Lenzen, M.J.; van Domburg, R.T.; Dulfer, K.

    2017-01-01

    Background It remains unclear whether feelings of being disabled are a relevant psychological factor that determines long term outcome after percutaneous coronary intervention (PCI). Therefore, we evaluated ‘feelings of being disabled’ as an independent risk factor for mortality 12 years post-PCI.

  11. Feelings of being disabled as a prognostic factor for mortality in men and women post-PCI up to 12years

    NARCIS (Netherlands)

    Bergmann, Michael J.; Utens, Elisabeth M. W. J.; de Jager, Tom A. J.; Radhoe, Sumant P.; Daemen, Joost; Lenzen, Mattie J.; van Domburg, Ron T.; Dulfer, Karolijn

    2017-01-01

    It remains unclear whether feelings of being disabled are a relevant psychological factor that determines long term outcome after percutaneous coronary intervention (PCI). Therefore, we evaluated 'feelings of being disabled' as an independent risk factor for mortality 12years post-PCI. The study

  12. Outcomes of Percutaneous Coronary Interventions for Chronic Total Occlusion Performed by Highly Experienced Japanese Specialists: The First Report From the Japanese CTO-PCI Expert Registry.

    Science.gov (United States)

    Suzuki, Yoriyasu; Tsuchikane, Etsuo; Katoh, Osamu; Muramatsu, Toshiya; Muto, Makoto; Kishi, Koichi; Hamazaki, Yuji; Oikawa, Yuji; Kawasaki, Tomohiro; Okamura, Atsunori

    2017-11-13

    This report describes the registry and presents an initial analysis of outcomes for the different PCI approaches taken by the specialists. Strategies for percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) are complex. The Japanese Board of CTO Interventional Specialists has developed a prospective, nonrandomized registry of patients undergoing CTO-PCIs performed by 41 highly experienced Japanese specialists. Over the study period of January 2014 to December 2015, the registry included 2,846 consecutive CTO-PCI cases undertaken in Japan. The authors compared clinical outcomes between the different PCI approaches, following the intention-to-treat principle. The overall technical success rate of the procedures was 89.9%. The specialists frequently chose a retrograde approach as the primary CTO-PCI strategy (in 27.8% of cases). The technical success rate of the primary antegrade approach was significantly better than that of the primary retrograde approach (91.0% vs. 87.3%; p PCI with a high technical success rate (75.0% to 88.9%). Severe lesion calcification was a strong predictor of failed CTO-PCI. CTO-PCI performed by highly experienced specialists achieved a high technical success rate. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  13. Aerobiological monitoring in the fields of health and environment; Il monitoraggio aerobiologico e le sue applicazioni in campo sanitario e ambientale

    Energy Technology Data Exchange (ETDEWEB)

    Cesare, M.R.; Bari, A. [ENEA, Rome (Italy). Div. Protezione dell' Uomo e degli Ecosistemi

    2000-10-01

    Aerobiology, a continuously evolving field, is used in environmental protection programmes to detect atmospheric changes as well as harmful biological particles. [Italian] L'aerobiologia e' una disciplina in continua evoluzione utilizzata nell'ambito dei programmi di protezione ambientale per evidenziare non solo le particelle biologiche nocive, ma anche i tradizionali inquinanti atmosferici.

  14. Retrograde CTO-PCI of Native Coronary Arteries Via Left Internal Mammary Artery Grafts: Insights From a Multicenter U.S. Registry.

    Science.gov (United States)

    Tajti, Peter; Karatasakis, Aris; Karmpaliotis, Dimitri; Alaswad, Khaldoon; Jaffer, Farouc A; Yeh, Robert W; Patel, Mitul; Mahmud, Ehtisham; Choi, James W; Doing, Anthony H; Toma, Catalin; Uretsky, Barry; Garcia, Santiago; Moses, Jeffrey W; Parikh, Manish; Kirtane, Ajay; Ali, Ziad A; Hatem, Raja; Karacsonyi, Judit; Danek, Barbara A; Rangan, Bavana V; Banerjee, Subhash; Ungi, Imre; Brilakis, Emmanouil S

    2018-03-01

    Retrograde percutaneous coronary intervention (PCI) of native coronary artery chronic total occlusion (CTO) via left internal mammary artery (LIMA) graft has received limited study. We compared the clinical and procedural characteristics and outcomes of retrograde CTO-PCI through LIMA grafts vs other conduits in a contemporary multicenter CTO registry. The LIMA was used as the collateral channel in 20 of 990 retrograde CTO-PCIs (2.02%) performed at 18 United States centers. The mean age of the study patients was 69 ± 7 years and 95% were men. The most common CTO target vessel was the right coronary artery (55%). The mean J-CTO score in the LIMA group was high (3.45 ± 0.76). The technical success rates were 70% for retrograde PCI via LIMA graft vs 81.05% for retrograde via other conduits (P=.25), while procedural success rates were 70% for retrograde PCI via LIMA graft and 78.19% for retrograde via other conduits (P=.41). The incidence of major in-hospital complications was also similar between the LIMA and non-LIMA retrograde groups (5% vs 6%; P>.99). Use of guide-catheter extensions (40% vs 28%; P=.22), intravascular ultrasound (45% vs 31%; P=.20), and left ventricular assist devices (24% vs 10%; P=.08) was numerically higher in retrograde CTO-PCIs via LIMA grafts. Retrograde CTO-PCI is infrequently performed via LIMA grafts and is associated with similar success and major in-hospital complication rates as retrograde CTO-PCI performed via other conduits.

  15. Le surpoids, l’obésité et le contrôle glycémique chez les diabétiques du centre de référence provincial de diabète (CRD), Kénitra, Maroc

    Science.gov (United States)

    Lotfi, Zeghari; Aboussaleh, Youssef; Sbaibi, Rachid; Achouri, Imane; Benguedour, Rachid

    2017-01-01

    Introduction Le diabète est définit comme un trouble de l'assimilation, de l'utilisation et du stockage des sucres apportés par l'alimentation, sa prise en charge est assurée par le suivi du surpoids et l'obésité et le contrôle glycémique régulier. L'objectif de ce travail était l'étude du surpoids, l'obésité et le contrôle glycémique chez 2227 diabétiques de différent type (type 1, 2 et gestationnel), consultants le centre de référence provincial de diabète (CRD), Kénitra-Maroc. Méthodes L'étude s'est déroulée sur une période d'une année du mois janvier au mois décembre 2015, L'évaluation du surpoids et l'obésité a été effectuée par le calcul de l'Indice de Masse Corporelle (IMC=Poids/Taille2 (Kg/m2)), elles sont définit respectivement par IMC > 25 Kg/m2, et IMC > 30 Kg/m2, le poids et la taille ont été mesurés selon les recommandations de l'organisation mondiale de santé (OMS), Le contrôle glycémique a été effectué par l'analyse sanguine de l'Hémoglobine glycosylée et de la Glycémie à jeun. Les normes sont 7% pour l'Hémoglobine glycosylée et 0,70g/l à 1,10g/l pour la Glycémie à jeun. Résultats L'intervalle d'âges des patients est compris entre 8 mois et 80 ans, avec une dominance des diabétiques provenant du milieu urbain (74%) par rapport à ceux provenant du milieu rural (26%). Le surpoids touche l'ensemble de cette population. L'IMC moyen des femmes tends vers l'obésité (IMC≈30): (29,21 Kg/m2 ± 3,1) pour le diabète gestationnel et (29,15 Kg/m2 ± 3,2) pour le diabète de type 2. Les valeurs du contrôle glycémique sont supérieures aux normes: avec 8,5% ± 2,6 > 7% pour l'hémoglobine glycosylée et 1,5 g/l ± 1,3 > 1,10g/l pour la Glycémie à jeun. La différence entre les valeurs de l'hémoglobine glycosylée entre les hommes (8,5 7% ± 2,6) et les femmes (8,1% ± 2,3) n'est pas significative (P > 0,05), même chose pour la Glycémie capillaire à jeun: pour les hommes (1,44 g/l ± 1,1) et les

  16. Ibrutinib (PCI-32765) in chronic lymphocytic leukemia.

    Science.gov (United States)

    Jain, Nitin; O'Brien, Susan

    2013-08-01

    B-cell receptor (BCR) signaling is essential for chronic lymphocytic leukemia (CLL) cell survival. Many kinases in the BCR signaling pathway are being studied as potential therapeutic targets. Ibrutinib (PCI-32765) is a novel first-in-class selective inhibitor of Bruton tyrosine kinase. Preclinical evidence suggests that ibrutinib inhibits CLL cell survival and proliferation and affects CLL cell migration and homing. Early clinical data in patients with CLL and non-Hodgkin lymphoma is encouraging. It is likely that ibrutinib and other drugs targeting the BCR pathway will become an integral component of CLL therapy. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. A validation study of the Brazilian version of the pornography consumption inventory (PCI) in a sample of female university students.

    Science.gov (United States)

    Baltieri, Danilo Antonio; Luísa de Souza Gatti, Ana; Henrique de Oliveira, Vitor; Junqueira Aguiar, Ana Saito; Almeida de Souza Aranha e Silva, Renata

    2016-02-01

    Although men constitute the widest consumer group of pornography, the Internet has facilitated both the production of and access to pornographic material by women as well. However, few measures are available to examine pornography-use constructs, which can compromise the reliability of statements regarding the harmful use of pornography. Our study aimed to confirm the factorial validity and internal consistency of the Pornography Consumption Inventory (PCI) in a sample of female university students in Brazil. The PCI is a four-factor, 15-item, five-point Likert-type scale. After translation and back-translation of the PCI, it was administered to 105 female medical students. Exploratory and confirmatory factor analyses were conducted to examine the construct validity. The results supported the four-factor model of the PCI. The model showed adequate internal reliability and good fit indices (comparative fit index (CFI) = 0.95, Tucker-Lewis index (TLI) = 0.94, root mean square error of approximation (RMSEA) = 0.07 (95% confidence interval (CI) = 0.04-0.09), and standardized root mean square residual (SRMR) = 0.08). Overall, the findings from this study support the use of the PCI in Portuguese-speaking women. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  18. Vers une typologie des modes de contrôle de gestion fondée sur la communication

    OpenAIRE

    Chtioui , Tawhid

    2008-01-01

    International audience; En se fondant sur la mesure comme fil directeur méthodologique, cette recherche montre l'interet d'une approche communicationnelle pour une meilleure compréhension du processus de contrôle de gestion. Pour ce faire, nous avons conduit une démarche de recherche en trois étapes : Une première phase empirique exploratoire a été menée, à travers un processus Delphi, auprès de 20 responsables de contrôle de gestion de 20 grandes entreprises françaises. Une deuxième phase em...

  19. Le LHC, un tunnel cosmique

    CERN Multimedia

    CERN. Geneva

    2009-01-01

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d’autres termes, qu’est-ce que le LHC peut nous apporter dans la connaissance de l’Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l’univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l’Univers ? La matière noire est-elle détectable au LHC ? L’énergie noire ? Pourquoi l’antimatière accumulée au CERN est-elle si rare dans l’Univers ? Et si le CERN a bâti sa réputation sur l’exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l’évolution cosmique ? Depuis une trentaine d’années, notre compréhension de l’univers dans ses plus grandes dimensions et l’appréhension de son comportement aux plus peti...

  20. Comparison of RISK-PCI, GRACE, TIMI risk scores for prediction of major adverse cardiac events in patients with acute coronary syndrome.

    Science.gov (United States)

    Jakimov, Tamara; Mrdović, Igor; Filipović, Branka; Zdravković, Marija; Djoković, Aleksandra; Hinić, Saša; Milić, Nataša; Filipović, Branislav

    2017-12-31

    To compare the prognostic performance of three major risk scoring systems including global registry for acute coronary events (GRACE), thrombolysis in myocardial infarction (TIMI), and prediction of 30-day major adverse cardiovascular events after primary percutaneous coronary intervention (RISK-PCI). This single-center retrospective study involved 200 patients with acute coronary syndrome (ACS) who underwent invasive diagnostic approach, ie, coronary angiography and myocardial revascularization if appropriate, in the period from January 2014 to July 2014. The GRACE, TIMI, and RISK-PCI risk scores were compared for their predictive ability. The primary endpoint was a composite 30-day major adverse cardiovascular event (MACE), which included death, urgent target-vessel revascularization (TVR), stroke, and non-fatal recurrent myocardial infarction (REMI). The c-statistics of the tested scores for 30-day MACE or area under the receiver operating characteristic curve (AUC) with confidence intervals (CI) were as follows: RISK-PCI (AUC=0.94; 95% CI 1.790-4.353), the GRACE score on admission (AUC=0.73; 95% CI 1.013-1.045), the GRACE score on discharge (AUC=0.65; 95% CI 0.999-1.033). The RISK-PCI score was the only score that could predict TVR (AUC=0.91; 95% CI 1.392-2.882). The RISK-PCI scoring system showed an excellent discriminative potential for 30-day death (AUC=0.96; 95% CI 1.339-3.548) in comparison with the GRACE scores on admission (AUC=0.88; 95% CI 1.018-1.072) and on discharge (AUC=0.78; 95% CI 1.000-1.058). In comparison with the GRACE and TIMI scores, RISK-PCI score showed a non-inferior ability to predict 30-day MACE and death in ACS patients. Moreover, RISK-PCI was the only scoring system that could predict recurrent ischemia requiring TVR.

  1. Analysis of Payment Card Industry Data Security Standard [PCI DSS] Compliance by Confluence of COBIT 5 Framework

    OpenAIRE

    Ashish Ukidve; Ds S SMantha; Milind Tadvalkar

    2017-01-01

    The Payment Card Industry Data Security Standard (PCI DSS) aims to enhance the security of cardholder data and is required when cardholder data or authentication data are stored, processed or transmitted. The implementation of enabling processes from COBIT 5 can complement compliance to PCI DSS. COBIT 5 assists enterprises in governance and management of enterprise IT and, at the same time, supports the need to meet security requirements with supporting processes and management activities. Th...

  2. Five-year outcomes following PCI with DES versus CABG for unprotected LM coronary lesions: meta-analysis and meta-regression of 2914 patients Desfechos de 5 anos do tratamento de lesões de TCE por stents farmacológicos versus CRM: metaanálise e meta-regressão de 2914 pacientes

    Directory of Open Access Journals (Sweden)

    Michel Pompeu Barros de Oliveira Sá

    2013-03-01

    Full Text Available OBJECTIVE: To compare the safety and efficacy at long-term follow-up of coronary artery bypass grafting (CABG with percutaneous coronary intervention (PCI using drug-eluting stents (DES in patients with unprotected left main coronary artery (ULMCA disease. METHODS: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles were searched for clinical studies that reported outcomes at 5-year follow-up after PCI with DES and CABG for the treatment of ULMCA stenosis. Five studies (1 randomized controlled trial and 4 observational studies were identified and included a total of 2914 patients (1300 for CABG and 1614 for PCI with DES. RESULTS: At 5-year follow-up, there was no significant difference between the CABG and PCI-DES groups in the risk for death (odds ratio [OR] 1.159, P=0.168 for random effect or the composite endpoint of death, myocardial infarction, or stroke (OR 1.214, P=0.083. The risk for target vessel revascularization (TVR was significantly lower in the CABG group compared to the PCI-DES group (OR 0.212, POBJETIVO: Comparar segurança e eficácia do seguimento a longo prazo da cirurgia de revascularização miocárdica (CRM com intervenção coronária percutânea (ICP, utilizando stents farmacológicos (SF em pacientes com lesão de tronco de coronária esquerda não-protegida (TCE. MÉTODOS: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar e listas de referências artigos relevantes foram escaneados para estudos clínicos que relataram resultados em 5 anos de seguimento após ICP-SF eCRM para o tratamento de lesão de TCE. Cinco estudos (um de ensaio clínico randomizado e quatro estudos observacionais foram identificados e incluíram um total de 2914 pacientes (1300 para CRM e 1614 para ICP-SF. RESULTADOS: Aos 5 anos de seguimento, não houve diferença significativa entre os grupos CRM e ICP-SF no risco de morte (odds ratio [OR] 1,159, P=0,168 ou desfecho composto de morte

  3. Peut-on voyager dans le temps ?

    CERN Multimedia

    CERN. Geneva

    2008-01-01

    La possibilité de voyager dans le temps est régulièrement évoquée par les magazines scientifiques (et parfois même par les scientifiques). Elle est également le sujet de nombreux romans de science-fiction. Nous discuterons d’abord du sens qu’on peut donner à l’expression « voyager dans le temps », puis nous expliciterons ce que la physique contemporaine dit à ce propos.

  4. Lele des associations  dans la médiation en archéologie

    OpenAIRE

    Sence, Christophe

    2014-01-01

    Le milieu associatif est connu en France pour son dynamisme et sa réactivité. Il en va de même en archéologie, notamment dans le domaine de la médiation. Si le public ignore bien souvent qu’une association se cache derrière le lieu qu’il vient de visiter, nombreux sont les sites archéologiques, toutes périodes confondues, dont la mise en valeur est entièrement assumée par une telle structure. Dans ce cadre, tout est envisageable, de la simple ouverture pendant les Journées européennes du patr...

  5. Effect of emergency PCI combined with rh-BNP therapy on neuroendocrine indicators and cardiac function in patients with acute anterior myocardial infarction

    Directory of Open Access Journals (Sweden)

    Yang Ji

    2016-06-01

    Full Text Available Objective: To analyze the effect of emergency PCI combined with rh-BNP therapy on neuroendocrine indicators and cardiac function in patients with acute anterior myocardial infarction. Methods: A total of 70 cases with acute anterior myocardial infarction who received emergency rescue in our hospital from February 2012 to September 2014 were included for study, and all included patients were divided into control group 38 cases who received emergency PCI treatment alone and observation group 32 cases who received emergency PCI combined with rh-BNP therapy. Differences in the values of neuroendocrine indicators, ventricular collagen remodeling-related indicators, cardiac function indicators, myocardial injury-related indicators and so on were compared between two groups after treatment. Results: Serum ET, PRA, ALD, AngII, NE and E values of observation group after treatment were significantly lower than those of control group (P<0.05; serum PⅠCP and PCⅢ values of observation group after treatment were lower than those of control group, and PⅠCP/ PCⅢ and TIMP-1 values were significantly higher than those of control group (P<0.05; examination of cardiac function by color Doppler ultrasound showed that LAD, LVEDD, LVESD, LVESV and LVEDV values of observation group were lower than those of control group, and LVEF and LVFS values were significantly higher than those of control group (P<0.05; serum CD14++CD2L+, hs-cTnT, HBDH and H-FABP values of observation group after treatment were significantly lower than those of control group, and CD14+CD2L- value was significantly higher than that of control group (P<0.05. Conclusions: Emergency PCI combined with rh-BNP therapy for patients with acute anterior myocardial infarction can significantly improve cardiac function and inhibit ventricular remodeling, and it has positive clinical significance.

  6. L’impossible seconde vie ? Le poids des standards éditoriaux et la résistance de la bande dessinée franco-belge au format de poche

    Directory of Open Access Journals (Sweden)

    Sylvain Lesage

    2011-07-01

    Full Text Available Si le livre de poche a joué un rôle central dans la diffusion du patrimoine littéraire, la bande dessinée ne dispose pas de cet outil permettant la constitution d’un corpus de classiques aisément accessibles au plus grand nombre. En ceci, la bande dessinée constitue bien une véritable exception dans le champ éditorial français, par la quasi-absence de collections permettant de republier des classiques en format de poche. L’importance de l’image et l’impératif de lisibilité compliquent en effet le problème de l’adaptation du « grand format » vers le poche, mais demeurent insuffisants pour comprendre la réticence de la bande dessinée au poche. Le présent article propose un retour en arrière sur les expériences des années 1980-1990, afin de mieux cerner cette singularité éditoriale.

  7. Improved recovery of regional left ventricular function after PCI of chronic total occlusion in STEMI patients: a cardiovascular magnetic resonance study of the randomized controlled EXPLORE trial.

    Science.gov (United States)

    Elias, Joëlle; van Dongen, Ivo M; Hoebers, Loes P; Ouweneel, Dagmar M; Claessen, Bimmer E P M; Råmunddal, Truls; Laanmets, Peep; Eriksen, Erlend; van der Schaaf, René J; Ioanes, Dan; Nijveldt, Robin; Tijssen, Jan G; Hirsch, Alexander; Henriques, José P S

    2017-07-19

    The Evaluating Xience and left ventricular function in PCI on occlusiOns afteR STEMI (EXPLORE) trial did not show a significant benefit of percutaneous coronary intervention (PCI) of the concurrent chronic total occlusion (CTO) in ST-segment elevation myocardial infarction (STEMI) patients on global left ventricular (LV) systolic function. However a possible treatment effect will be most pronounced in the CTO territory. Therefore, we aimed to study the effect of CTO PCI compared to no-CTO PCI on the recovery of regional LV function, particularly in the CTO territory. Using cardiovascular magnetic resonance (CMR) we studied 180 of the 302 EXPLORE patients with serial CMR (baseline and 4 months follow-up). Segmental wall thickening (SWT) was quantified on cine images by an independent core laboratory. Dysfunctional segments were defined as SWT PCI compared to no-CTO PCI (ΔSWT 17 ± 27% vs 11 ± 23%, p = 0.03). This recovery was most pronounced in the dysfunctional but viable segments(TEI PCI compared with no-CTO PCI is associated with a greater recovery of regional systolic function in the CTO territory, especially in the dysfunctional but viable segments. Further research is needed to evaluate the use of CMR in selecting post-STEMI patients for CTO PCI and the effect of regional LV function recovery on clinical outcome. Trialregister.nl NTR1108 , Date registered NTR: 30-okt-2007.

  8. Le CRDI à la COP23 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En collaboration avec ses bénéficiaires et partenaires, le CRDI anime et participe à une série d'activités et d'événements durant la COP23, y compris des événements parallèles officiels de la CCNUCC et des groupes d'experts, des groupes de discussion, des ateliers et la 15e édition des Journées sur le développement et ...

  9. Le colonel Rol-Tanguy

    OpenAIRE

    Bourderon, Roger

    2009-01-01

    Ouvrier métallurgiste, syndicaliste et communiste, le futur colonel Rol-Tanguy, né en 1908, se passionne pour le métier des armes lors de son service militaire. Son expérience dans les Brigades internationales est décisive. Il l’enrichit dans les FTP puis comme chef régional FFI : il prépare et conduit l’insurrection parisienne avec un état-major comportant de nombreux cadres de l’armée. Compagnon de la Libération, il se distingue dans la campagne d’Allemagne et est intégré dans l’armée avec ...

  10. Prediction of functional recovery after primary PCI using the estimate of myocardial salvage in gated SPECT early after acute myocardial infarction

    Energy Technology Data Exchange (ETDEWEB)

    Calabretta, Raffaella; Castello, Angelo; Linguanti, Flavia; Tutino, Francesca; Ciaccio, Alfonso; Sciagra, Roberto [University of Florence, Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences ' ' Mario Serio' ' , Florence (Italy); Giglioli, Cristina [Careggi University Hospital, Cardiothoracovascular Department, Florence (Italy)

    2018-04-15

    Primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) aims to achieve myocardial salvage (MS). Because the reference method for measuring MS requires myocardial perfusion imaging (MPI) after tracer injection before PCI, alternative approaches have been proposed, but none has gained wide acceptance. Gated SPECT MPI can assess infarct size (IS), but can also show myocardial stunning. Thus, we compared functional and perfusion abnormalities early after AMI to estimate MS, and to predict left ventricular ejection fraction (LVEF) recovery at follow-up. We studied 120 patients with AMI. Gated SPECT MPI was performed early (before hospital discharge) and at 6 months after AMI to measure IS, MS and functional outcome. MS was defined as the difference between the number of segments with abnormal thickening (i.e. the stunned area or area at risk) and the number of segments with abnormal perfusion (i.e. the final IS), expressed as a percentage of the total number of segments in the AHA model. LVEF was calculated using quantitative gated SPECT. The area at risk was 40 ± 25%, IS was 17.3 ± 16% and MS was 22 ± 19%. Early LVEF was 46.6 ± 11.6% and late LVEF was 51.4 ± 11.6%, with 54 patients showing at least an increase in LVEF of more than 5 units. ROC analysis showed that MS was able to predict LVEF recovery with an area under the curve (AUC) of 0.79 (p < 0.0001), and using a cut off >23% detected LVEF recovery with 74% sensitivity and 71% specificity. Conversely, IS was associated with an AUC 0.53 (not significant). MS assessed by a single early gated SPECT MPI study can accurately predict LVEF evolution after primary PCI for AMI. (orig.)

  11. Feelings of being disabled as a prognostic factor for mortality in men and women post-PCI up to 12years.

    Science.gov (United States)

    Bergmann, Michael J; Utens, Elisabeth M W J; de Jager, Tom A J; Radhoe, Sumant P; Daemen, Joost; Lenzen, Mattie J; van Domburg, Ron T; Dulfer, Karolijn

    2017-12-15

    It remains unclear whether feelings of being disabled are a relevant psychological factor that determines long term outcome after percutaneous coronary intervention (PCI). Therefore, we evaluated 'feelings of being disabled' as an independent risk factor for mortality 12years post-PCI. The study population comprised a consecutive series of CAD patients (n=845) treated with PCI as part of the Taxus-Stent Evaluated At Rotterdam Cardiology Hospital (T-SEARCH) registry. Of these patients n=646 (age 63years, 75% male) completed the subscale 'feelings of being disabled' of the Heart Patients Psychological Questionnaire (HPPQ), within the first month after PCI. At 12year follow-up, n=209 patients (32%) died. Of the 162 females n=73 (45%) experienced high feelings of being disabled (High-FOBD) and of the 484 males, n=134 (28%) reported high-FOBD. Patients with high feelings of being disabled had a two-fold increased risk of mortality at 12-year follow-up (HR=1.86, 95% CI=1.41-2.45). After adjusting, high feelings of being disabled remained a predictor of 12-year mortality (HR=2.53, 95% CI=1.30-4.90). This study confirms that psychosocial variables like feelings of being disabled influence cardiac morbidity and mortality. Furthermore, there is no difference in mortality between men and women with high feelings of being disabled 12years post-PCI. It is important that clinicians are aware that PCI-patients who feel disabled have a less favorable survival and that the difference in survival is even greater for women who feel disabled. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  12. Editorial L&E, v.7, n.2, 2013.

    Directory of Open Access Journals (Sweden)

    Rede Conpadre

    2013-04-01

    Full Text Available Editorial L&E, v.7, n.2, 2013 Neste ano, o prêmio jovem cientista do Conselho Nacional de Pesquisa e Desenvolvimento (CNPq adotou como tema central “Água. Desafios da Sociedade”. Esta edição da Revista Labor & Engenho (L&E, v.7, n.2, 2013 reúne oito artigos, todos voltados às questões do desenvolvimento regional, enfocando principalmente a ordenação e o uso do território, o patrimônio local e a conformação da paisagem. Todavia, três deles são voltados diretamente para as questões de uso e ocupação do solo e, água. A Lei 9433/97 trouxe muitos avanços em relação ao antigo código das águas de 1930. Definiu como espaço territorial para o planejamento e gestão, a bacia hidrográfica; definiu que a prática do planejamento e gestão devem integrar com o planejamento de uso e ocupação do solo; assim como questões de quantidade e qualidade da água devem estar associadas. Foram definidos novos instrumentos para a gestão como o plano de recursos hídricos; o sistema de informações; a outorga e; a cobrança pela captação de água bruta. Além de definir a Política Nacional para Gestão de Recursos Hídricos, a Lei apresenta o Sistema Nacional para Gestão de Recursos Hídricos, que entre outros, atribui o domínio governamental das águas nos níveis Federativo e Estadual. Desde a regulamentação da Lei, não se pode negar os avanços. Mas é um consenso, da práxis e do mundo acadêmico-científico, que há muitas lacunas a serem preenchidas até que se possa observar o controle efetivo através das outorgas concedidas e da cobrança, a elaboração e integração do Plano Nacional (já regulamentado e os Planos Estaduais de Recursos Hídricos (alguns já regulamentados, o Sistema Nacional de Informações sobre Recursos Hídricos, a gestão participativa, a racionalidade, as práticas de conservação da água, o manejo adequado e, equilíbrio entre escassez e excessos de águas pluviais, a sustentabilidade atrav

  13. O Jardim da Villa Stein-de Monzie: Um projeto de Le Corbusier e Pierre Jeanneret (versão de 1926

    Directory of Open Access Journals (Sweden)

    Silvia Odebrecht

    2010-06-01

    Full Text Available O presente artigo aborda uma análise pouco trabalhada na literatura especializada, sobre o jardim da Villa Stein-de Monzie, também conhecida como Les Terrasses, na versão de 1926, desenvolvida por Le Corbusier e Pierre Jeanneret. Esse jardim não foi construído e essa pode ser uma das principais causas por não se encontrar uma documentação gráfica completa de seu projeto. A detalhada descrição aqui apresentada permite imaginar como teria ficado a propriedade de Les Terrasses se o projeto do jardim tivesse sido executado. A reflexão deste trabalho é uma lição sobre história da arquitetura, sobre a obra de Le Corbusier e Pierre Jeanneret e uma referência à pesquisa sobre o paisagismo moderno.

  14. Jean-François Gallotte, Joëlle Malberg, Carbone 14 le film, Les Mutins de Pangée

    OpenAIRE

    Curien, Julie

    2014-01-01

    Carbone 14 le film est un témoignage sur le mouvement des radios libres, à travers l'exemple de « Carbone 14 », « la radio active » devenue « la radio qui vous encule par les oreilles ». Filmé en 4 jours à la rentrée 1982, avec du matériel volé, le film ovni de Jean-François Galotte et Joëlle Malberg est sélectionné au Festival de Cannes en 1983. Il fait un tollé qui retombe comme une crêpe, aux oubliettes : on n'en parle plus avant... 2011, trente ans après la création de la radio culte et c...

  15. Le parrain de baptême vu par son filleul ou la portée sociale d'un rôle sacré

    Directory of Open Access Journals (Sweden)

    1976-01-01

    Full Text Available Qu'est-ce qu'un parrain de baptême? Dans le cadre d'une recherche plus générale orientée vers l'institution du compadrazgo telle qu'elle existe aujourd'hui dans une communauté indigène du district d'Ollachea (province de Carabaya, département de Puno, l'auteur a voulu laisser la parole aux intéressés, c'est-à-dire aux filleuls, aux adolescents qui vivent la relation filleul(e - parrain et qui sont élevés dans le respect de cette parenté rituelle. Une brève introduction rappelle ce que sont, dans le monde andin, le parrainage et le compadrazgo. Dans la partie suivante, sous le titre Contexte et méthodologie, l'auteur précise les caractéristiques d'Ollachea, délimite la population concernée et décrit dans quelles conditions les documents écrits ont été recueillis. Il livre ensuite, pour permettre au lecteur familiarisé avec les sociétés andines de se reporter au texte original et d'en vérifier l'interprétation, l'ensemble des matériaux bruts. La quatrième partie est consacrée à l'examen et à l'étude de ces matériaux. L'auteur décompose leur contenu complexe en éléments plus simples et regroupe les différentes formules autour d'un certain nombre de thèmes. Enfin, sur la base de ces thèmes et de leur fréquence mais en utilisant aussi les énoncés, riches de signification, et sa connaissance, acquise par l'étude directe, de la société en question, l'auteur s'efforce de tracer l'image du parrain de baptême telle qu'elle est perçue par les adolescents. Il dégage ainsi le portrait d'un personnage incontestablement important mais dont on attend qu'il assume, plus qu'un rôle de guide spirituel, celui d'un agent qui permet l'intégration du filleul dans le monde social. ¿Qué es un padrino de bautismo? Dentro de una investigación más amplia orientada hacia la Institución del compadrazgo tal como existe hoy en una comunidad indígena del distrito de Ollachea (en la provincia de Carabaya del departamento

  16. PCI/SCC failure behavior of KWU/CE fuel rods

    International Nuclear Information System (INIS)

    Kikuchi, Akira

    1983-10-01

    The Over Ramp (Studsvik Over Ramp-STOR) project is an international power ramping irradiation program for studying PCI/SCC failure behavior of PWR-fuel rods. The project had its activities for about three years (Apr., 1977 - Dec., 1980) as the cooperation works of twelve participants composing nine countries. The present report introduces the irradiation data on the KWU/CE fuel rods in the project and discusses the failure behavior of PWR-fuel rods. (author)

  17. Percutaneous coronary intervention versus coronary artery bypass grafting in patients with end-stage renal disease requiring dialysis (5-year outcomes of the CREDO-Kyoto PCI/CABG Registry Cohort-2).

    Science.gov (United States)

    Marui, Akira; Kimura, Takeshi; Nishiwaki, Noboru; Mitsudo, Kazuaki; Komiya, Tatsuhiko; Hanyu, Michiya; Shiomi, Hiroki; Tanaka, Shiro; Sakata, Ryuzo

    2014-08-15

    Ischemic heart disease is a major risk factor for morbidity and mortality in patients with end-stage renal disease. However, long-term benefits of percutaneous coronary intervention (PCI) relative to coronary artery bypass grafting (CABG) in those patients is still unclear in the drug-eluting stent era. We identified 388 patients with multivessel and/or left main disease with end-stage renal disease requiring dialysis among 15,939 patients undergoing first coronary revascularization enrolled in the Coronary REvascularization Demonstrating Outcome Study in Kyoto PCI/CABG Registry Cohort-2 (PCI: 258 patients and CABG: 130 patients). The CABG group included more patients with 3-vessel (38% vs 57%, p PCI group (23.5 ± 8.7 vs 29.4 ± 11.0, p PCI and 5.4% for CABG. Cumulative 5-year all-cause mortality was 52.3% for PCI and 49.9% for CABG. Propensity score-adjusted all-cause mortality was not different between PCI and CABG (hazard ratio [HR] 1.33, 95% confidence interval [CI] 0.85 to 2.09, p = 0.219). However, the excess risk of PCI relative to CABG for cardiac death was significant (HR 2.10, 95% CI 1.11 to 3.96, p = 0.02). The risk of sudden death was also higher after PCI (HR 4.83, 95% CI 1.01 to 23.08, p = 0.049). The risk of myocardial infarction after PCI tended to be higher than after CABG (HR 3.30, 95% CI 0.72 to 15.09, p = 0.12). The risk of any coronary revascularization after PCI was markedly higher after CABG (HR 3.78, 95% CI 1.91 to 7.50, p PCI reduced the risk of cardiac death, sudden death, myocardial infarction, and any revascularization. However, the risk of all-cause death was not different between PCI and CABG. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Expression Study of LeGAPDH, LeACO1, LeACS1A, and LeACS2 in Tomato Fruit (Solanum lycopersicum

    Directory of Open Access Journals (Sweden)

    Pijar Riza Anugerah

    2015-10-01

    Full Text Available Tomato is a climacteric fruit, which is characterized by ripening-related increase of respiration and elevated ethylene synthesis. Ethylene is the key hormone in ripening process of climacteric fruits. The objective of this research is to study the expression of three ethylene synthesis genes: LeACO1, LeACS1A, LeACS2, and a housekeeping gene LeGAPDH in ripening tomato fruit. Specific primers have been designed to amplify complementary DNA fragment of LeGAPDH (143 bp, LeACO1 (240 bp, LeACS1A (169 bp, and LeACS2 (148 bp using polymerase chain reaction. Nucleotide BLAST results of the complementary DNA fragments show high similarity with LeGAPDH (NM_001247874.1, LeACO1 (NM_001247095.1, LeACS1A (NM_001246993.1, LeACS2 (NM_001247249.1, respectively. Expression study showed that LeACO1, LeACS1A, LeACS2, and LeGAPDH genes were expressed in ripening tomato fruit. Isolation methods, reference sequences, and primers used in this study can be used in future experiments to study expression of genes responsible for ethylene synthesis using quantitative polymerase chain reaction and to design better strategy for controlling fruit ripening in agroindustry.

  19. Le Valais et ses Reines

    Directory of Open Access Journals (Sweden)

    Alberto Campi

    2012-06-01

    Full Text Available Combat de ReinesAu premier plan (la corde dans la main, un propriétaire de vaches. Dans l'arène se trouve le rabatteur. Les Reines sur la photo sont des reines de première catégorie (ainsi que le montre le « I » sur leur cuisse .Dimanche 6 mai 2012, « Schakira », la vache numéro 42, a gagné, non sans polémique, le titre de Reine. Elle peut donc être considérée comme la Reine des Reines, titre qu’elle a gagné en se battant contre ses rivales dans différents combats, qui ont commencé pour Sch...

  20. Accessibilité aux emplois en France : lele de la distance à la ville

    Directory of Open Access Journals (Sweden)

    Mohamed Hilal

    2004-12-01

    Full Text Available L'objet de cet article est de modéliser les niveaux d’accessibilité potentielle aux emplois des communes françaises selon lele de la distance à la ville. Pour ce faire, nous présentons, tout d’abord, un modèle d’accessibilité et la méthode mise en œuvre pour calculer de façon systématique, à partir des données du réseau routier, une matrice des plus courts chemins, mesurés en temps, entre les communes françaises. Ensuite, dans la deuxième partie, ces distances sont intégrées dans le modèle d’accessibilité retenu afin de mesurer la disponibilité potentielle aux emplois selon la distance au pôle urbain le plus proche et selon les principales catégories d’espace du zonage en aires urbaines et de son complément rural. Enfin, la mesure d’accessibilité potentielle est comparée à plusieurs mesures d’accessibilité empirique.

  1. Le Service Accueil et Contrôle d'Accès

    CERN Document Server

    Ducastel, C

    1999-01-01

    L'utilisateur qui vient au CERN pour la première fois, est accueilli généralement par les membres du service 'Accueil et Contrôle d'Accès'. Cet utilisateur sera tout d'abord orienté vers un des postes d'hôtesses d'accueil en charge de l'enregistrement et de la délivrance de cartes CERN. Les informations seront saisies et immédiatement disponibles et transmises, via le système AMS, aux équipements de contrôle d'accès et à la Centrale de Surveillance des accès, chargée de la supervision de tout le dispositif de contrôle d'accès au domaine. Ces contrôles aux entrées et accueil des visiteurs individuels sont complétés par des missions de surveillance à l'intérieur du Domaine pour les agents, et par des travaux de gestions de dossiers administratifs (service enregistrement) pour les hôtesses. Un contrat commun assure une uniformité de formation des agents et hôtesses. Ce contrat est assorti d'une clause de Bonus Malus afin de tendre vers une optimisation des performances.

  2. LA RÉÉCRITURE DU MYTHE D’ORPHÉE DANS LE BESTIAIRE OU CORTÈGE D’ORPHÉE DE GUILLAUME LA RÉÉCRITURE DU MYTHE D’ORPHÉE DANS LE BESTIAIRE OU CORTÈGE D’ORPHÉE DE GUILLAUME APOLLINAIRE

    Directory of Open Access Journals (Sweden)

    Julie Dekens

    2009-04-01

    Full Text Available Cette oeuvre se compose de trente courts poèmes – pour l’essentiel des quatrains formés d’octosyllabes ou d’alexandrins – accompagnés chacun d’une gravure sur bois de Raoul Dufy, auxquels sont associés des animaux dont le nom constitue le titre de ces pièces poétiques. Apollinaire joue donc dans ce cadre avec les motifs orphiques, aventure qui semble d’autant plus périlleuse si l’on s’aperçoit que ces thématiques ont été le terrain de jeu de nombreux poètes avant lui…Cette oeuvre se compose de trente courts poèmes – pour l’essentiel des quatrains formés d’octosyllabes ou d’alexandrins – accompagnés chacun d’une gravure sur bois de Raoul Dufy, auxquels sont associés des animaux dont le nom constitue le titre de ces pièces poétiques. Apollinaire joue donc dans ce cadre avec les motifs orphiques, aventure qui semble d’autant plus périlleuse si l’on s’aperçoit que ces thématiques ont été le terrain de jeu de nombreux poètes avant lui…

  3. Le rapport Coopération pour le développement de l'OCDE souligne ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    14 févr. 2018 ... Cette 55e édition du rapport Coopération pour le développement fournit une analyse exhaustive des contraintes liées aux données auxquelles les pays en développement sont confrontés de nos jours, ainsi que des options stratégiques visant à compiler de meilleures statistiques pour le développement ...

  4. Le dermatofibrosarcome de Darier et Ferrand, une tumeur cutanée particulière: à propos de 32 cas et revue de la littérature

    Science.gov (United States)

    Elamrani, Driss; Droussi, Hatim; Boukind, Samira; Elatiqi, Keltoum; Dlimi, Meriem; Benchamkha, Yassine; Ettalbi, Saloua

    2014-01-01

    Le dermatofibrosarcome (DFS) est une tumeur fibreuse de la peau, de croissance lente, à très haut risque de récidive locale, mais à potentiel métastatique faible. A partir d'une étude rétrospective étalée sur une période de 5 ans (décembre 2008 - décembre 2013), nous avons analysé les caractéristiques épidémiologiques et cliniques, le délai de diagnostic, le type de thérapeutique et le devenir de 32 patients présentant des tumeurs de Darier et Ferrand histologiquement prouvées. Parmi les 32 patients, 10 se sont présentés initialement au service pour une récidive tumorale. Une discrète prédominance masculine a été notée. Les DFS touchent préférentiellement l'adulte jeune. Le délai diagnostique observé est en moyenne de 4 ans. Le tronc est la localisation préférentielle (60%), suivi par les extrémités proximales (30%). Les 32 patients ont été traités par exérèse chirurgicale avec une marge de 5cm en surface, emportant en profondeur une barrière anatomique saine. La couverture de la perte de substance (PDS) a été réalisée après confirmation anatomopathologique du caractère carcinologique de l'exérèse, et a fait appel à différents moyens allant de la greffe cutanée aux lambeaux musculo –cutanés libres. L’évolution a été marquée par la survenue d'une récidive tumorale chez 8 patients (3 cas parmi les tumeurs vues en première intention et 5 cas parmi les tumeurs vues en récidive) et les résultats ont été jugés satisfaisants sur le plan esthétique et fonctionnel. Le DFS de Darier et Ferrand est une tumeur dont le pronostic et le risque évolutif sont principalement liés au délai diagnostic et la qualité de la première exérèse. Le diagnostic tardif, rend difficile la chirurgie d'exérèse et de reconstruction Les possibilités de guérison en cas de chirurgie primaire bien conduite sont significativement supérieures à celles d'une chirurgie de rattrapage. L'amélioration du pronostic passe par

  5. Le laboratoire, le temple et le marché

    International Development Research Centre (IDRC) Digital Library (Canada)

    De manière générale, les auteurs insistent sur le fait que c'est leur foi qui leur a .... nettement que dans de nombreux cercles, le besoin était vivement ressenti de ... Le Dr Kapur présente tout d'abord une brève discussion sur sa vision du ...... pour les soins aux enfants orphelins et aux pauvres et pour la renaissance des ...

  6. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial.

    Science.gov (United States)

    van Nunen, Lokien X; Zimmermann, Frederik M; Tonino, Pim A L; Barbato, Emanuele; Baumbach, Andreas; Engstrøm, Thomas; Klauss, Volker; MacCarthy, Philip A; Manoharan, Ganesh; Oldroyd, Keith G; Ver Lee, Peter N; Van't Veer, Marcel; Fearon, William F; De Bruyne, Bernard; Pijls, Nico H J

    2015-11-07

    In the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) study, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) improved outcome compared with angiography-guided PCI for up to 2 years of follow-up. The aim in this study was to investigate whether the favourable clinical outcome with the FFR-guided PCI in the FAME study persisted over a 5-year follow-up. The FAME study was a multicentre trial done in Belgium, Denmark, Germany, the Netherlands, Sweden, the UK, and the USA. Patients (aged ≥ 18 years) with multivessel coronary artery disease were randomly assigned to undergo angiography-guided PCI or FFR-guided PCI. Before randomisation, stenoses requiring PCI were identified on the angiogram. Patients allocated to angiography-guided PCI had revascularisation of all identified stenoses. Patients allocated to FFR-guided PCI had FFR measurements of all stenotic arteries and PCI was done only if FFR was 0·80 or less. No one was masked to treatment assignment. The primary endpoint was major adverse cardiac events at 1 year, and the data for the 5-year follow-up are reported here. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00267774. After 5 years, major adverse cardiac events occurred in 31% of patients (154 of 496) in the angiography-guided group versus 28% (143 of 509 patients) in the FFR-guided group (relative risk 0·91, 95% CI 0·75-1·10; p=0·31). The number of stents placed per patient was significantly higher in the angiography-guided group than in the FFR-guided group (mean 2·7 [SD 1·2] vs 1·9 [1·3], pPCI in patients with multivessel disease. A strategy of FFR-guided PCI resulted in a significant decrease of major adverse cardiac events for up to 2 years after the index procedure. From 2 years to 5 years, the risks for both groups developed similarly. This clinical outcome in the FFR-guided group was achieved with a lower number of stented arteries

  7. Le Chatelier principle in replicator dynamics

    OpenAIRE

    Allahverdyan, Armen E.; Galstyan, Aram

    2011-01-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nas...

  8. Le Culture preistoriche

    OpenAIRE

    Tanda, Giuseppa

    1987-01-01

    Le più antiche manifestazioni della presenza dell'uomo, nella provincia di Sassari (e in Sardegna), risalgono al Quaternario: sono state osservate nel 1979, nel bacino del rio Altana-Anzos, situato nel territorio dei comuni di Laerru e Perfugas. Il presente lavoro propone un excursus dal Paleolitico al Neolitico (antico, medio e recente) fino all'Età del Rame e all'Età del Bronzo (II metà del III millennio-1600 a.C.).

  9. Le naturalisme, arme de la rupture : Emilia Pardo Bazán et le conte rural

    Directory of Open Access Journals (Sweden)

    Christian Boyer

    2013-03-01

    Full Text Available Avec la publication de La cuestión palpitante, série d’articles avec lesquels elle introduisit le naturalisme en Espagne, Emilia Pardo Bazán fut très critiquée par ses contemporains. Cette rupture par rapport à la norme sociale, vers laquelle ni son statut ni son sexe n’auraient dû la mener, fut accompagnée d’une autre rupture : celle d’avec les conventions littéraires. En effet, dans de nombreux récits courts, le milieu rural est dépeint sans aucune idéalisation mais est au contraire le théâtre de nombreux crimes. Pour Emilia Pardo Baz��n, la cruauté ne fut pas simplement un moyen de s’imposer dans un monde littéraire masculin mais aussi un formidable outil pour dénoncer l’ignorance, la cupidité d’une société viciée.

  10. Direct transport to a PCI-capable hospital is associated with improved survival after adult out-of-hospital cardiac arrest of medical aetiology.

    Science.gov (United States)

    McKenzie, Nicole; Williams, Teresa A; Ho, Kwok M; Inoue, Madoka; Bailey, Paul; Celenza, Antonio; Fatovich, Daniel; Jenkins, Ian; Finn, Judith

    2018-05-02

    To compare survival outcomes of adults with out-of-hospital cardiac arrest (OHCA) of medical aetiology directly transported to a percutaneous-coronary-intervention capable (PCI-capable) hospital (direct transport) with patients transferred to a PCI-capable hospital via another hospital without PCI services available (indirect transport) by emergency medical services (EMS). This retrospective cohort study used the St John Ambulance Western Australia OHCA Database and medical chart review. We included OHCA patients (≥18 years) admitted to any one of five PCI-capable hospitals in Perth between January 2012 and December 2015. Survival to hospital discharge (STHD) and survival up to 12-months after OHCA were compared between the direct and indirect transport groups using multivariable logistic and Cox-proportional hazards regression, respectively, while adjusting for so-called "Utstein variables" and other potential confounders. Of the 509 included patients, 404 (79.4%) were directly transported to a PCI-capable hospital and 105 (20.6%) transferred via another hospital to a PCI-capable hospital; 274/509 (53.8%) patients STHD and 253/509 (49.7%) survived to 12-months after OHCA. Direct transport patients were twice as likely to STHD (adjusted odds ratio 1.97, 95% confidence interval [CI] 1.13-3.43) than those transferred via another hospital. Indirect transport was also associated with a possible increased risk of death, up to 12-months, compared to direct transport (adjusted hazard ratio 1.36, 95% CI 1.00-1.84). Direct transport to a PCI-capable hospital for post-resuscitation care is associated with a survival advantage for adults with OHCA of medical aetiology. This has implications for EMS transport protocols for patients with OHCA. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. « Le souvenir de la nature dans le sujet ». Une actualité de La Dialectique de la raison

    Directory of Open Access Journals (Sweden)

    Gilles Moutot

    2010-09-01

    Full Text Available On se propose de montrer que le « souvenir de la nature dans le sujet », un des thèmes majeurs de La Dialectique de la raison, trouve une actualité spécifique dans certains débats et travaux contemporains. Dans la mesure où elle est pensée sous la condition de la remémoration, et donc de son intrication avec l’histoire, l’expérience que le sujet peut faire de la nature en lui apparaît nouée à une visée critique et normative qui cependant se garde de toute surcharge naturaliste (telle qu’elle s’aperçoit par exemple dans les diverses conceptions d’une nature-modèle : contre la violence des identités socialement contraintes, il s’agit de prêter attention à ce qui atteste, à même les impulsions somatiques, le lien entre aspiration à la liberté et souci de ce dont on ne peut disposer (en termes adorniens, le « non-identique ». Une telle approche est susceptible d’éclairer les prolongements actuels de la Théorie critique, par exemple là où celle-ci s’efforce de penser les souffrances sociales.

  12. Quand la musique donne le ton

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2017-01-01

    Le lycée Sainte-Anne de Copenhague est un établissement réputé pour les résultats de ses élèves et pour être le foyer d’une intense tradition chorale et musicologique. L’article interroge les parcours de 32 élèves d’une même classe, tous reçus au baccalauréat 2014 avec une option musique et mathé...... de comprendre cette coexistence entre musique et éducation, la relation entre « individu » et « communauté » est examinée et la notion de « culture » désigne le point d’articulation qui peut rendre compte de la dynamique pédagogique en question....

  13. Lele des chefs traditionnels au Ghana : un modèle inspirant ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 févr. 2011 ... Avec ses partenaires du Sud, avec aussi le soutien du Centre de recherches pour le développement international ( CRDI ), organisme canadien, Ray a étudié lele des chefs traditionnels au Ghana dans la lutte contre le VIH et le sida. Les collectivités politiques antérieures au colonialisme sont une ...

  14. Stéréotyper le Féminin: entre le Doxique et l’Esthétique (Estereotipar o Feminino: entre o Dóxico e o Estético)

    OpenAIRE

    Maingueneau, Dominique; UNIVERSITÉ PARIS XII - VAL-DE-MARNE – PARIS/FRANCE

    2007-01-01

    RÉSUMÉ Cet article cherche à montrer que l’attitude masculine à l’égard des stéréotypes sur les femmes peut correspondre à deux manières de “gérer” l’énigme que représente pour l’homme la différence sexuelle: un régime doxique, celui de l’ “Homme Ordinaire”, et un régime esthétique, celui de “l’Artiste”. Le premier régime trouve à se manifester dans les proverbes, par exemple, dont la visée essentielle est de définir un ordre dans lequel le féminin se voit assigner “sa” place. Il est illustré...

  15. Extension de la plate-forme DSM-PM2 pour le support de protocoles de cohérence relâchée multithreads

    OpenAIRE

    Antoniu , Gabriel; Bernardi , Vincent; Bougé , Luc

    2001-01-01

    International audience; Dans leur présentation traditionnelle, les bibliothèques de gestion de mémoire distribuée virtuel- lement partagée (MVP, en anglais DSM) [8, 11, 12, 4] permettent à des processus de partager un espace d'adressage commun selon un modèle de cohérence fixé. L'objectif du projet DSM-PM2 est de fournir au programmeur d'application distribuée multithread une plate-forme d'implémen- tation où il puisse développer et optimiser conjointement son application et le protocole de c...

  16. Microsofti sõda Googleþi vastu / Jay Greene

    Index Scriptorium Estoniae

    Greene, Jay

    2008-01-01

    Microsofti konkurentsist Googleþiga, ettevõtte uuest strateegiast saavutada ülekaal internetireklaamiturul. Graafik. Lisad: Microsofti reklaamiimperatiiv; Veebireklaami turg; Tarkvara kolib veebi; Google'i eduseis; Reklaamimaht kasvab

  17. Festivals de cinéma dans le monde arabe

    Directory of Open Access Journals (Sweden)

    Jean-Michel Frodon

    2013-12-01

    Full Text Available Alors que les deux grands festivals « historiques » du monde arabe, Carthage (JCC et Le Caire, sont entrés en décadence, on assiste depuis le début des années 2000 à une véritable explosion du phénomène festivalier dans le monde arabe. Le pays le plus en pointe est le Maroc, quoique de manière contrastée, avec une manifestation de prestige à Marrakech, et une nuée de petites manifestations. Dans les émirats du Golfe, la multiplication des festivals traduit une stratégie de communication plutôt qu’une volonté de développement culturel. Cette stratégie est fragilisée par la concurrence que se livrent les différents acteurs. Dans les autres pays arabes, on trouve une grande variété de situations sous le signe de la dispersion. Pourtant, l’accumulation de festivals (une centaine dans la région finit par avoir des effets d’ensemble, au-delà des buts, moyens et limites de chacun d’eux. Le phénomène festivalier, bien qu’inscrit dans des agendas locaux ou nationaux, génère de manière plus vaste des réseaux générationnels, financiers, de procédures d’expertise, de processus d’interrelation, géographiques mais aussi entre le cinéma et les autres arts ou médias.

  18. Temporal Trends in the Risk Profile of Patients Undergoing Outpatient Percutaneous Coronary Intervention: A Report from the National Cardiovascular Data Registry's CathPCI Registry.

    Science.gov (United States)

    Vora, Amit N; Dai, Dadi; Gurm, Hitinder; Amin, Amit P; Messenger, John C; Mahmud, Ehtisham; Mauri, Laura; Wang, Tracy Y; Roe, Matthew T; Curtis, Jeptha; Patel, Manesh R; Dauerman, Harold L; Peterson, Eric D; Rao, Sunil V

    2016-03-01

    Because of recent changes in criteria for coverage for inpatient hospital stays, most nonacute percutaneous coronary intervention (PCI) procedures are reimbursed on an outpatient basis regardless of underlying patient risk. Downstream effects of these changes on the risk profile of patients undergoing outpatient PCI have not been evaluated. Using the American College of Cardiology National Cardiovascular Data Registry's CathPCI Registry, we assessed temporal trends in risk profiles and rates of hospital admission among 999 279 patients undergoing PCI qualifying for outpatient reimbursement. We estimated mortality and bleeding risk using validated models from the registry. From 2009 to 2014, the proportion of outpatients not admitted to a hospital after PCI increased from 32.8% to 66.3% (Prisk for predicted mortality increased significantly from 17.0% to 19.8% during the study period (Prisk for mortality. Among patients undergoing PCI procedures that qualify for outpatient reimbursement, there has been a temporal decrease in postprocedure hospital admission. Concomitantly, the proportion of these outpatients at high risk for mortality has significantly increased over time. These data suggest that current reimbursement classification could be improved by incorporating patient risk to appropriately match the necessary resources to the needed level of care. © 2016 American Heart Association, Inc.

  19. Le briciole di Pollicino. Vita nascosta delle strade tra età romana e Medioevo / “Le briciole di Pollicino” (Pollicino’s breadcrumbs. The hidden history of roads between the Roman Age and the Middle Ages

    Directory of Open Access Journals (Sweden)

    Umberto Moscatelli

    2013-05-01

    Full Text Available Tra le strutture del paesaggio, forse le strade sono quelle che più di altre evocano la dimensione del tempo, perché lungo di esse si sono allineati per secoli spazi e strutture dell’insediamento militare, religioso, civile e produttivo. Questa è la ragione per cui l’attenzione degli studiosi si è spesso concentrata sugli aspetti della continuità della rete stradale romana nel tempo. Se tuttavia, in tale prospettiva tematica, consideriamo in modo obiettivo la quantità e la qualità dei dati che ci sono pervenuti, dobbiamo ammettere che spesso del tessuto viario sono rimaste tracce discontinue e difficilmente disambiguabili. Questo contributo propone quindi alcune riflessioni sull’approccio comunemente praticato agli studi sull’evoluzione della rete stradale nel tempo, sul modo stesso di utilizzare le fonti e di valutarne le loro caratteristiche (peso testimoniale, collocazione nel tempo e nello spazio delle informazioni che contengono e sulle problematiche connesse all’implementazione di dati fortemente eterogenei ai fini della costruzione di un discorso storico.   Maybe the ancient roads, more than other landscape structures, suggest the idea of the past, because they have always attracted spaces and structures of the military, religious, civil and productive settlement. For this reason, the scholars' attention is often focused on the aspects of the continuity of the Roman road network over time. However, if we consider objectively the quantity and quality of the data we have at our disposal, we see that they often consist of discontinuous and rather ambiguous traces. This paper offers some reflections on the approach commonly practised in the researches on the evolution of the road network over time, on the way the sources are used and evaluated in order to their depth and in order to the position in time and space of the information they contain, and finally on the problems arising from the implementation of highly

  20. Le modèle standard de la physique des particules de l'électron au boson de Higgs

    CERN Document Server

    Samueli, Jean-Jacques

    2013-01-01

    Le modèle standard de la physique des particules est une théorie qui décrit les constituants élémentaires de la matière et les interactions qui existent entre eux. Le présent ouvrage est un exposé du développement historique de ce modèle qui suppose que toute la matière est composée de quarks et de leptons, particules ponctuelles de spin 1?2. On dénombre trois générations de quarks et autant de leptons. Les interactions faible, forte et électromagnétique sont, pour leur part, décrites par des théories de jauge dont la médiation est effectuée par des quanta de jauge de spin 1. Ces médiateurs sont les ? , W + , W ? , Z ainsi que huit gluons. La gravitation est par ailleurs analysée dans l'ouvrage dans sa formulation classique et relativiste. Enfin le mécanisme dit de Englert-Brout-Higgs prévoit des particules de spin zéro, correspondant à un champ scalaire qui est supposé donner une masse aux quarks, leptons et aux bosons vecteurs intermédiaires W + , W ? , Z . Nous décrivons ce m�...

  1. Dans le tourbillon des particules

    CERN Document Server

    Zito, Marco

    2015-01-01

    Accélérateurs géants, détecteurs complexes, particules énigmatiques... La physique subatomique peut sembler bien intimidante pour le novice. Et pourtant, qui n a jamais entendu parler du boson de Higgs et du CERN, le laboratoire européen où il a été découvert en 2012 ? Nul besoin d être un spécialiste pour comprendre de quoi il s agit. Aujourd hui, une théorie extraordinairement élégante, le Modèle Standard, décrit tous les résultats des expériences dans le domaine. Trente-sept particules élémentaires et quatre forces fondamentales : c est tout ce dont nous avons besoin pour expliquer la matière et l Univers ! Ce livre, destiné à un large public, raconte sans équations le long parcours qui a abouti au Modèle Standard. Ce parcours, parfois sinueux, a été entamé lorsque les Grecs anciens, et peut-être d autres avant eux, ont imaginé que la matière est composée de petites « billes ». Il faudra attendre plusieurs siècles pour qu on réalise que la matière, à l échelle micros...

  2. Méditerranée asiatique : un modèle urbain polycentrique

    OpenAIRE

    Gipouloux , François

    2012-01-01

    Publication de la revue "Diplomatie. Affaires stratégiques et relations internationales" http://www.diplomatie-presse.com/; International audience; En Asie orientale, un corridor maritime a pris forme autour de plates-formes logistiques et portuaires, fidèles au modèle de Hong Kong. C'est là que bat le coeur de l'économie régionale.

  3. Économie | Page 5 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Une table ronde sur l'industrie du vêtement en Asie s'est tenue le 26 mars 2015 à Phnom Penh, au Cambodge. Elle était organisée par le Cambodia Development Resource Institute (CDRI) et commanditée par le CRDI. Plus de 45 intervenants de l'industrie du vêtement ont participé à cet événement, notamment des ...

  4. Empezar a escribir microrrelatos en E/LE en cuatro pasos

    Directory of Open Access Journals (Sweden)

    Dorota Kotwica

    2014-09-01

    Full Text Available En el presente artículo se describe una secuencia de cuatro actividades de expresión escrita diseñada para un aula de E/LE en niveles entre B2 y C1 según el Marco Común Europeo de Referencia para las lenguas. El objetivo final que se persigue en esta secuencia es que los alumnos se inicien en la escritura de microrrelato en español. Para conseguirlo, se plantean actividades ordenadas en cuanto el grado de libertad que se ofrece al alumno a la hora de escribir, desde prácticas más pautadas hasta un ejercicio de escritura libre. El planteamiento de la secuencia fomenta, además, la comunicación y la interacción en el aula.

  5. Tra utopia e rivoluzione: le visioni di Diego Rivera al Rockefeller Center di New York

    Directory of Open Access Journals (Sweden)

    Amalda Cuka

    2016-11-01

    Full Text Available I murales eseguiti da Diego Rivera (1886–1957 al Rockefeller Center di New York nel 1933 sono fra le più note opere d’arte scomparse. Ad aver reso celebre il dipinto non è stato il successo di pubblico, data la rimozione del lavoro ancora in corso d’opera, ma il ricchissimo dibattito alimentato dalla stampa intorno alla concezione dell’immagine, considerata negli Stati Uniti totalmente rivoluzionaria per la particolare tecnica dell’affresco utilizzata da Rivera, per i riferimenti all’arte precolombiana e per le idee politiche esposte. Un’occasione di riflessione è offerta in questa sede dall’attenzione che uno dei principali organi di stampa americani, il New York Times, ha dedicato all’argomento: dalla lettura dei numerosi interventi emerge, da una parte, la capacità di Rivera di entrare in comunicazione con un vasto pubblico, e dall’altra il ruolo avuto dalla stampa nella diffusione - quasi involontaria - del suo messaggio. Rivera è riuscito a raggiungere in tal modo, almeno parzialmente, il suo scopo: l’opera non è stata accessibile al grande pubblico, ma la conoscenza dei principi che voleva celebrare si è diffusa in maniera ancor più capillare.

  6. Comparative effectiveness of coronary artery bypass grafting (CABG) surgery and percutaneous coronary intervention (PCI) in elderly patients with diabetes.

    Science.gov (United States)

    Shah, Ruchit; Yang, Yi; Bentley, John P; Banahan, Benjamin F

    2016-11-01

    To compare the relative effectiveness of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) among elderly patients with diabetes regarding acute myocardial infarction (AMI), stroke, repeat revascularization, and all-cause mortality. A retrospective cohort study was conducted using the 2006-2008 5% national sample of Medicare claims data. Elderly (≥65 years) beneficiaries with at least two claims of diabetes separated by ≥30 days and who had at least one inpatient claim for multi-vessel CABG or PCI between 1 July 2006 and 30 June 2008 were identified. The date of beneficiary's first CABG or PCI was defined as the index date. All patients were followed from the index date to 31 December 2008 for outcomes. CABG and PCI patients were 1:1 matched on propensity scores and index dates. Cox proportional hazards models were used to compare postoperative outcomes between patients undergoing CABG versus PCI. The matched sample consisted of 4430 patients (2215 in each group). The Cox proportional hazards models showed that, compared to patients undergoing PCI, CABG was associated with a lower risk of postoperative AMI (hazard ratio [HR]: 0.494; 95% CI: 0.396-0.616; p < .0001), repeat revascularization (HR: 0.194; 95% CI: 0.149-0.252; p < .0001), the composite outcome (HR: 0.523; 95% CI: 0.460-0.595; p < .0001), and all-cause mortality (HR: 0.775; 95% CI: 0.658-0.914; p = .0024); postoperative risk of stroke was not significantly different between the two groups (HR: 0.965; 95% CI: 0.812-1.148; p = .691). CABG appears to be the preferred revascularization strategy for elderly patients with diabetes and coronary heart disease. However, this result should be interpreted considering study limitations, for example, several patient clinical variables and physician-related factors which may affect procedure outcomes are not available in the data. Clinical decisions should be individualized considering all patient- and physician

  7. La mosquée et le cimetière. Espaces du sacré et pouvoir symbolique à Constantine en 1936

    OpenAIRE

    McDougall, James

    2013-01-01

    Cet essai propose une lecture de la signification d’un moment et d’un espace, vers la fin des années trente à Constantine. Deux épisodes d’affrontement entre acteurs de la société constantinoise autour du rassemblement de la communauté lors d’événements religieux (le retour des pèlerins, fêté à la Grande mosquée en avril 1936, et la zarda dite ‘de Sidi Aty’, célébrée en octobre dans le cimetière de la ville), rendent visible un ensemble d’enjeux et de conflits au sein de la société citadine à...

  8. Achieving timely percutaneous reperfusion for rural ST-elevation myocardial infarction patients by direct transport to an urban PCI-hospital.

    Science.gov (United States)

    Bennin, Charles-Lwanga K; Ibrahim, Saif; Al-Saffar, Farah; Box, Lyndon C; Strom, Joel A

    2016-10-01

    ST-elevation myocardial infarction (STEMI) guidelines recommend reperfusion by primary percutaneous coronary intervention (PCI) ≤ 90 min from time of first medical contact (FMC). This strategy is challenging in rural areas lacking a nearby PCI-capable hospital. Recommended reperfusion times can be achieved for STEMI patients presenting in rural areas without a nearby PCI-capable hospital by ground transportation to a central PCI-capable hospital by use of protocol-driven emergency medical service (EMS) STEMI field triage protocol. Sixty STEMI patients directly transported by EMS from three rural counties (Nassau, Camden and Charlton Counties) within a 50-mile radius of University of Florida Health-Jacksonville (UFHJ) from 01/01/2009 to 12/31/2013 were identified from its PCI registry. The STEMI field triage protocol incorporated three elements: (1) a cooperative agreement between each of the rural emergency medical service (EMS) agency and UFHJ; (2) performance of a pre-hospital ECG to facilitate STEMI identification and laboratory activation; and (3) direct transfer by ground transportation to the UFHJ cardiac catheterization laboratory. FMC-to-device (FMC2D), door-to-device (D2D), and transit times, the day of week, time of day, and EMS shift times were recorded, and odds ratio (OR) of achieving FMC2D times was calculated. FMC2D times were shorter for in-state STEMIs (81 ± 17 vs . 87 ± 19 min), but D2D times were similar (37 ± 18 vs . 39 ± 21 min). FMC2D ≤ 90 min were achieved in 82.7% in-state STEMIs compared to 52.2% for out-of-state STEMIs (OR = 4.4, 95% CI: 1.24-15.57; P = 0.018). FMC2D times were homogenous after adjusting for weekday vs . weekend, EMS shift times. Nine patients did not meet FMC2D ≤ 90 min. Six were within 10 min of target; all patient achieved FMC2D ≤ 120 min. Guideline-compliant FMC2D ≤ 90 min is achievable for rural STEMI patients within a 50 mile radius of a PCI-capable hospital by use of protocol-driven EMS ground

  9. La coesistenza delle religioni in Albania. Le religioni in Albania prima e dopo la caduta del comunismo

    Directory of Open Access Journals (Sweden)

    Maria Gabriella Belgiorno de Stefano

    2014-02-01

    Full Text Available Il contributo, accettato dal Direttore, riproduce il testo della Relazione al Convegno sul tema “Libertà Religiosa, Secolarizzazione e Sviluppi recenti in Albania” (Roma, Sala della Protomoteca in Campidoglio, 3 febbraio 2014, organizzato dall’Ambasciata della Repubblica di Albania presso la Santa Sede e presso il Sovrano Militare Ordine di Malta e dalla Presidenza Assemblea Capitolina (Roma Capitale.SOMMARIO: 1. Premessa - 2. Le origini del Kanun albanese - 3. La fratellanza religiosa albanese - 4. Il primo comunismo albanese e la libertà religiosa - 5. L’ateocrazia albanese - 6. La fratellanza albanese e la Costituzione del 1998.

  10. Le patrimoine et ses outils de gestion

    CERN Document Server

    Garcin, J

    2001-01-01

    Les principale taches de gestion du Patrimoine immobilier du CERN sont la saisie des données, leur mise à jour, l'archivage et la mise à disposition des informations. Les outils de gestion actuels : Le Système de Gestion de Base de Données Relationnelles alphanumérique ORACLE permet de gérer toutes les informations du Patrimoine, sur le réseau du CERN. Le logiciel de dessin Graphique MICROSTATION (Bentley) a été installé dans la division ST depuis fin 1991. Les plans de situation des sites, des bâtiments et locaux, des espaces confinés ont été réalisés avec ce logiciel. Les outils de demain : La mise en place du SIG (Système d'Information Graphique) STAR a été réalisée en 1993. Le transfert des plans de locaux de MICROSTATION vers STAR est en cours depuis une année environ. Le dessin de la cartographie des réseaux de canalisations Eaux Usées et Eaux Pluviales est en cours de réalisation. Le Web est l'outil de consultation de l'information par les utilisateurs.

  11. Le développement durable, la fête et le match de football : impressions de terrain (mars 2008 depuis le village de Watoriki, en terre indigène Yanomami

    Directory of Open Access Journals (Sweden)

    François-Michel Le Tourneau

    2009-11-01

    Full Text Available Le texte qui suit inaugure la section de synthèses de terrain annoncée dans le précédent numéro de Confins. Répondant aux critères posés, il s’agit avant tout d’un recueil d’impressions et d’éléments bruts, qui ont ensuite été retravaillés pour former la synthèse de terrain sur la zone de Watoriki, publiée en ligne dans la collection Hal-SHS du projet DURAMAZ. Les circonstances et les objectifs de la mission se trouvaient liés à ce dernier. Le village de Watoriki était l’une des treize zones ...

  12. Évaluation spatiale et prospectives sur le risque de pollution diffuse par le nitrate sur le bassin versant de la Bultière

    Directory of Open Access Journals (Sweden)

    LE FLAHEC, François

    2015-06-01

    Full Text Available En France, la protection des captages d'eau potable est une préoccupation majeure : le Grenelle Environnement a identifié plus de cinq cents sites menacés par les pollutions diffuses, d'où la nécessité de mettre en place des plans d'action pour les protéger. En Vendée, dans le bassin versant de la Bultière, confronté à des rejets importants de nitrate, une étude par modélisation agronomique et hydrologique a été mise en œuvre avec le logiciel Swat, un outil alliant analyse spatiale et simulation, qui doit permettre de donner des orientations et de prioriser des solutions.

  13. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

    Science.gov (United States)

    Herman, Sarah E. M.; Gordon, Amber L.; Hertlein, Erin; Ramanunni, Asha; Zhang, Xiaoli; Jaglowski, Samantha; Flynn, Joseph; Jones, Jeffrey; Blum, Kristie A.; Buggy, Joseph J.; Hamdy, Ahmed

    2011-01-01

    B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse models its mutation has a relatively B cell–specific phenotype. Herein, we demonstrate that BTK protein and mRNA are significantly over expressed in CLL compared with normal B cells. Although BTK is not always constitutively active in CLL cells, BCR or CD40 signaling is accompanied by effective activation of this pathway. Using the irreversible BTK inhibitor PCI-32765, we demonstrate modest apoptosis in CLL cells that is greater than that observed in normal B cells. No influence of PCI-32765 on T-cell survival is observed. Treatment of CD40 or BCR activated CLL cells with PCI-32765 results in inhibition of BTK tyrosine phosphorylation and also effectively abrogates downstream survival pathways activated by this kinase including ERK1/2, PI3K, and NF-κB. In addition, PCI-32765 inhibits activation-induced proliferation of CLL cells in vitro, and effectively blocks survival signals provided externally to CLL cells from the microenvironment including soluble factors (CD40L, BAFF, IL-6, IL-4, and TNF-α), fibronectin engagement, and stromal cell contact. Based on these collective data, future efforts targeting BTK with the irreversible inhibitor PCI-32765 in clinical trials of CLL patients is warranted. PMID:21422473

  14. Publications | Page 50 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La prochaine flambée épidémique : se préparer à l'imprévisible. Les maladies infectieuses ignorent les frontières, que ce soit le virus Ebola qui se propage de la Guinée au Liberia, la rougeole qui s'est déclarée dans la vallée du Fraser et dont le virus a été introduit au Canada par.

  15. Derechos Humanos y memoria histórica: nuevas propuestas de aprendizaje, reflexión y crítica en la clase de E/LE

    Directory of Open Access Journals (Sweden)

    Luz C. Souto

    2016-11-01

    Full Text Available El presente trabajo tiene como objetivo la formación de alumnos de E/LE en temas relacionados con la memoria histórica y los Derechos Humanos. La propuesta se realiza a través de obras literarias, cómics y documentales de base testimonial. Se analizará el caso concreto de los niños que el régimen franquista expropió entre la finalización de la guerra civil española y mediados de los años 50, y cómo esta práctica, dirigida a reeducar a los hijos de los vencidos, derivó en un negocio de robo de niños, muy presente en la prensa española actual. Se abordarán conceptos como identidad, memoria, democracia/dictadura. Las actividades propuestas están enfocadas, principalmente, a alumnos de los niveles B1/B2, C1/C2.   Palabras clave: clase de E/LE, memoria histórica, expropiación de niños, dictadura franquista.   Human rights and historical memory: new proposals for learning, reflection and critical thinking in the class of E / LE Abstract: This work is aimed at the formation of E/LE students in historical memory issues and Human Rights. This proposal is made in the context of the literature, comics and documentaries. The specific case of stolen children by the Franco regime will be discussed between the end of the Spanish Civil War and the first half of the 50’s, and how this situation was a business Concepts such as identity, memory, democracy/dictatorship will be addressed. The proposed activities are focused on the level B1/B2, C1/C2.   Keywords: E/LE, historical memory, expropriation of children, Franco's dictatorship.

  16. Le Chatelier's principle in replicator dynamics

    Science.gov (United States)

    Allahverdyan, Armen E.; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  17. Les géographes et le patrimoine

    Directory of Open Access Journals (Sweden)

    Anne Herzog

    2011-12-01

    Full Text Available Le patrimoine : l’émergence d’un objet dans les champs de recherche des géographes, révélateur d’une géographie conçue comme science de l’espace des sociétésLe patrimoine est devenu un objet commun des géographes. Dans un article de 2007, Vincent Veschambre montre clairement l’émergence des problématiques patrimoniales dans la géographie française contemporaine durant les années 1990, tout en soulignant l’entrée tardive et décalée des géographes dans « le concert patrimonial » par rapport à d...

  18. Le Parti paysan d’union sociale

    OpenAIRE

    Bensoussan, David

    2015-01-01

    La fondation, le 11 juillet 1945 à Paris, du Parti paysan n’a sans doute guère suscité l’attention des contemporains alors immergés dans le contexte tumultueux de l’immédiat après-guerre. Il faut d’ailleurs attendre la parution, quelque temps plus tard, le 6 octobre, du premier numéro de L’Unité Paysanne, organe hebdomadaire de cette nouvelle formation politique, pour que sa naissance soit publiquement officialisée. Sans vouloir surévaluer l’importance d’une organisation qui n’arrivera jamais...

  19. Le glaive de la parole

    Directory of Open Access Journals (Sweden)

    Luce Marchal-Albert

    2006-09-01

    Full Text Available Chacun sait, selon le mot de Pierre Viret, « en quelle confusion est la Chrestienté » au xvie siècle en Europe. C’est le deuxième quart du siècle qui nous intéressera ici, et en particulier l’année 1545, qui constitue une année charnière qui voit vaciller l’Église romaine, flamber et culminer la chasse aux hérétiques en même temps qu’elle voit la jeune Église réformée se renforcer et se positionner avec succès dans un champ religieux plus que chaotique. Les ouvrages polémiques réformés écrits...

  20. Le Comunità greca e illirica di Trieste: dalla separazione ecclesiastica alla collaborazione economica (XVIII - XIX secolo)

    OpenAIRE

    Miklic, Vanja

    2014-01-01

    2012/2013 Nel XVIII secolo, in seguito alla dichiarazione del Porto franco, Trieste si trasformò in una città-porto cosmopolita. Le nuove comunità etnico-religiose, e in particolar modo i greci, gli illirici e gli ebrei usufruirono della favorevole politica economica, dei privilegi commerciali ma soprattutto dell’alto livello di tolleranza religiosa garantiti dal governo asburgico. Questo atteggiamento imperiale contribuì a consolidare la fiducia delle comunità immigrate nel governo centra...

  1. Association entre le travail par quarts et l’obésité chez les hommes dans le nord-est de l’Ontario

    Directory of Open Access Journals (Sweden)

    Anne Grundy

    2017-01-01

    Full Text Available Introduction : Même si certaines études suggèrent une association entre le travail par quarts et l’obésité, peu sont fondées sur la population ou tiennent compte de divers horaires de travail par quarts. L’obésité étant associée à plusieurs problèmes de santé chroniques, il est important de comprendre quelles formes de travail par quarts ont une incidence sur elle et d’effectuer des travaux permettant d’évaluer de façon plus détaillée l’exposition au travail par quarts. Méthodologie : Au moyen d’une régression logistique polytomique multivariée, nous avons étudié l’association entre le travail par quarts (de soir ou nuit, par quarts ou autre type de rotation et le surpoids et l’obésité, en fonction d’une mesure transversale de l’indice de masse corporelle chez 1 561 hommes. Ces hommes avaient déjà servi de témoins dans une étude cas-témoins sur le cancer de la prostate menée dans le nord-est de l’Ontario de 1995 à 1999. Nous avons obtenu l’information sur leurs antécédents de travail (notamment sur le travail par quarts, leur taille et leur poids à partir de données autodéclarées recueillies par questionnaire. Résultats : Nous avons observé une association entre le fait d’avoir déjà travaillé par quarts (par opposition au fait de n’avoir jamais travaillé par quarts et le surpoids (RC [rapport de cotes] = 1,34; IC [intervalle de confiance] à 95 % : 1,05 à 1,73 ainsi que l’obésité (RC = 1,57; IC à 95 % : 1,12 à 2,21. Nous avons également observé des associations statistiquement non significatives avec le fait d’avoir déjà travaillé (par opposition au fait de n’avoir jamais travaillé de façon permanente selon un quart de soir ou de nuit. Nous avons par ailleurs observé une tendance à la hausse statistiquement significative en ce qui concerne le risque de surpoids et d’obésité en fonction de la durée du travail par quarts. Conclusion : Tant l

  2. L'espace, un outil de contrôle ? : Le cas Pont-à-Mousson (1921-190

    OpenAIRE

    Labardin, Pierre

    2011-01-01

    Cet article s'intéresse aux impacts des open space en matière de contrôle à partir d'un travail historique. Nous nous demandons si l'espace de travail peut constituer un outil de contrôle opérationnel. Dans une première partie, nous proposons une définition historique des espaces travail qui nous amène à justifier notre méthodologie de recherche historique. Nous travaillons à partir des archives des années 1920 de la société Pont-à- Mousson. Nous présentons longuement le contexte de la mise e...

  3. The effect of power change on the PCI failure threshold

    Energy Technology Data Exchange (ETDEWEB)

    Sipush, P J; Kaiser, R S [Westinghouse Nuclear Fuel Division, Pittsburg, PA (United States)

    1983-06-01

    Investigations of the PCI mechanism have led to the conclusion that the failure threshold is best defined by the power change ({delta}P) during the ramp, rather than the final power achieved at the end of the ramp. The data base studied was comprehensive and includes a wide variety of water reactor systems and fuel designs. It has also been found that operating parameters have a more significant effect on failure susceptibility than fuel rod design variables. The most significant operating variable affecting the failure threshold was found to be the base irradiation history, indicating that fission product release and migration prior to the ramp (during base irradiation) is an important consideration. It can be shown that fuel irradiated at relatively higher linear heat ratings ends to fail at lower {delta}P. This effect has also been independently verified by statistical analyses which will also be discussed. Industry out-of-pile internal gas pressurization tests with irradiated tubing in the absence of simulated fission product species and at low stress levels, also tends to indicate the importance of the prior irradiation history on PCI performance. Other parameters that affect the power ramping performance are the initial ramping power and the pellet power distribution which is a function of fuel enrichment and burnup. (author)

  4. Patients undergoing PCI from the femoral route by default radial operators are at high risk of vascular access-site complications.

    Science.gov (United States)

    Rafie, Ihsan M; Uddin, Muez M; Ossei-Gerning, Nicholas; Anderson, Richard A; Kinnaird, Timothy D

    2014-02-01

    Radial artery (RA) access for PCI has a lower incidence of vascular access-site (VAS) complications than the femoral artery (FA) approach. However, even for default radial operators certain patients are intervened upon from the FA. We examined the demographics and incidence of VAS complications when default radial operators resort to the FA for PCI. The demographics and VAS complications were compared by access site retrospectively for all PCI cases performed by default radial operators (n=1,392). A modified ACUITY trial definition of major VAS complication was used. FA puncture occurred in 25.2% (351/1,392) of cases. Patients were more likely to be female, older and weigh less than patients undergoing PCI from the RA. The FA procedure was likely to be more complex with larger sheaths, more left main stem, graft and multivessel intervention, and there was a greater proportion of emergency cases. Despite increased case complexity, glycoprotein inhibitors were used less frequently in femoral cases (26.5% vs. 36.8%, prisk factors for access-site bleeding are disproportionately high in the population requiring FA puncture by default radial operators, and as a result such patients have a high rate of vascular access-site complications.

  5. Le fictif et le réel dans L’Empereur et l’assassin de Chen Kaige

    Directory of Open Access Journals (Sweden)

    Xiaomin Giafferri

    2008-12-01

    Full Text Available Comme tout texte historique littéraire refait l’Histoire en la manipulant, le récit filmique est doublement mensongère du fait de sa double représentation : le décor et les acteurs représentent une situation qui est la fiction, et le film lui-même représente sous forme d’images juxtaposées cette première représentation. Sans vouloir faire la part du réel et de l’imaginaire, le présent travail tente de montrer comment, dans le film L’empereur et l’assassin de Chen Kaige, l’illusion de l’authenticité s’établit à travers les mécanismes de la fictionnalisation de l’Histoire. L’observation de leur manifestation est amenée à considérer deux axes principaux : l’organisation du récit et la mise en scène des personnages.

  6. Publications | Page 173 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    E-Commerce in the Asian Context : Selected Case Studies. Le commerce électronique en Asie retient beaucoup l'attention en raison de la prolifération des connexions Internet et des technologies connexes dans la région. Face à cette tendance, le Centre de recherches pour le développement international (.

  7. Ultrafast intramolecular charge transfer with N-(4-cyanophenyl)carbazole. Evidence for a LE precursor and dual LE + ICT fluorescence.

    Science.gov (United States)

    Galievsky, Victor A; Druzhinin, Sergey I; Demeter, Attila; Mayer, Peter; Kovalenko, Sergey A; Senyushkina, Tamara A; Zachariasse, Klaas A

    2010-12-09

    The photophysics of N-(4-cyanophenyl)carbazole (NP4CN) was investigated by using absorption and fluorescence spectra, picosecond fluorescence decays, and femtosecond transient absorption. In the nonpolar n-hexane as well as in the polar solvent acetonitrile (MeCN), a locally excited (LE) state is detected, as a precursor for the intramolecular charge transfer (ICT) state. A LE → ICT reaction time τ(2) at 22 °C of 0.95 ps in ethyl cyanide (EtCN) and 0.32 ps in MeCN is determined from the decay of the LE excited state absorption (ESA) maximum around 620 nm. In the ESA spectrum of NP4CN in n-hexane at a pump-probe delay time of 100 ps, an important contribution of the LE band remains alongside the ICT band, in contrast to what is observed in EtCN and MeCN. This shows that a LE ⇄ ICT equilibrium is established in this solvent and the ICT reaction time of 0.5 ps is equal to the reciprocal of the sum of the forward and backward ICT rate constants 1/(k(a) + k(d)). In the photostationary S(0) → S(n) absorption spectrum of NP4CN in n-hexane and MeCN, an additional CT absorption band appears, absent in the sum of the spectra of its electron donor (D) and acceptor (A) subgroups carbazole and benzonitrile. This CT band is located at an energy of ∼4000 cm(-1) lower than for N-phenylcarbazole (NPC), due to the larger electron affinity of the benzonitrile moiety of NP4CN than the phenyl subunit of NPC. The fluorescence spectrum of NP4CN in n-hexane at 25 °C mainly consists of a structured LE emission, with a small ICT admixture, indicating that a LE → ICT reaction just starts to occur under these conditions. In di-n-pentyl ether (DPeE) and di-n-butyl ether (DBE), a LE emission is found upon cooling at the high-energy edge of the ICT fluorescence band, caused by the onset of dielectric solvent relaxation. This is not the case in more polar solvents, such as diethyl ether (DEE) and MeCN, in which a structureless ICT emission band fully overlaps the strongly quenched LE

  8. Plaidoyer pour le lavage de nez dans les pathologies naso ...

    African Journals Online (AJOL)

    Le lavage de nez permet l'humidification des muqueuses partant favorise le nettoyage mucociliaire en enlevant voire diminuant les croutes favorise leur élimination et ainsi la guérison en réduisant le recours aux antibiotiques [4-10]. Sans danger, le lavage de nez est bien tolérée tant chez les enfants que chez les adultes.

  9. Dalla parola all'immagine. Le prediche figurate di Daniel Hopfer e il ruolo della grafica nella diffusione della dottrina evangelica

    OpenAIRE

    Butera, Valeria

    2016-01-01

    Lo studio si concentra su alcune acqueforti dell'artista di Augusta Daniel Hopfer (1471-1536) di soggetto religioso, che illustrano preghiere, proverbi, parabole e altri passi del Vangelo in forma narrativa e che risultano chiaramente influenzate dalle idee riformate. Dopo un approfondimento del contesto storico e culturale e delle opinioni dei maggiori riformatori in merito alla questione delle immagini, le originali opere di Hopfer sono state messe a confronto con gli scritti omiletici e ca...

  10. BILAN DES ACTIONS DU PLAN MIGRATEURS CONCERNANT L’ALOSE FEINTE (ALOSA FALLAX RHODANENSIS SUR LE BASSIN RHÔNE-MÉDITERRANÉE-CORSE.

    Directory of Open Access Journals (Sweden)

    LEBEL I.

    2001-07-01

    Full Text Available La mise en place du premier volet du plan migrateurs Rhône-Méditerranée a nécessité tout un ensemble de travaux d’aménagement et d’ingénierie pour améliorer la libre circulation des poissons dans la zone concernée. Cet ensemble d’interventions a été accompagné d’études pour suivre ou optimiser les travaux d’aménagement, ainsi que de mesures réglementaires. Sur le Rhône et ses affluents, les trois écluses de navigation de Vallabrègues, d’Avignon et de Caderousse ont été aménagées pour permettre la réalisation d’éclusées réservées spécialement au passage des poissons tandis que de nombreux seuils ont été modifiés ou équipés pour favoriser leur franchissement par les aloses. L’ensemble des études a permis d’abord d’améliorer les connaissances sur la taxinomie, la biologie et l’écologie de l’alose feinte du Rhône. Les résultats ont ainsi mis en évidence une sous-espèce endémique qui renforce l’intérêt d’un programme de restauration des stocks dans une optique de maintien de la biodiversité. Le suivi de la pêcherie amateur aux engins a permis de préciser la fenêtre optimale de migration des aloses, et les facteurs influant sur la remontée de reproduction des adultes. Les résultats des campagnes de comptages visuels et d’échosondage ont montré l’efficacité globale des éclusées à poissons en tant que système de franchissement de l’ouvrage. Seul le comptage visuel permettrait d’évaluer le nombre de poissons franchissant l’obstacle, tout en restant assujetti à des contraintes techniques et à des imprécisions inhérentes à cette technique. Enfin, l’étude récente de la pêche sportive par carnets de pêche s’avère particulièrement utile dans une analyse qualitative de l’extension de la zone colonisée par les aloses, qui a incontestablement augmenté ces sept dernières années. En 1998, un bilan scientifique des actions et études menées depuis

  11. As faces e funções da tradução em sala de aula de LE.DOI: 10.5007/2175-7968.2011v1n27p161

    Directory of Open Access Journals (Sweden)

    Sinara de Oliveira Branco

    2011-11-01

    Full Text Available Este artigo tem o objetivo de discutir e demonstrar como a tradução pode ser aplicada em sala de aula de línguas estrangeiras (LE de forma eficaz, sem interferir negativamente na aquisição da língua estrangeira e utilizando, em casos específicos, a língua materna (LM ou a própria LE como recurso tradutório. Para tanto, a Abordagem Funcionalista da Tradução de Nord (1997 será utilizada como base teórica, bem como as categorias de tradução de Jakobson (2000. A partir da discussão da teoria, serão apresentados exercícios de tradução que descrevam o uso e eficácia tradutórios no contexto de aprendizagem de LE. Os resultados demonstram que há uma desmistificação quanto ao uso da tradução nesse contexto e que a LM passa a ter sua importância e valor novamente reconhecidos no aprendizado de LE.

  12. Le Combat de l’amour divin et de l’amour profane : un ballet de Charpentier pour le collège d’Harcourt

    OpenAIRE

    Demeilliez , Marie

    2014-01-01

    International audience; De l’activité de Marc-Antoine Charpentier au service des jésuites, nous sont parvenus un vaste répertoire religieux ainsi que le célèbre « opéra chrétien » David et Jonathas (1688), l’une des rares partitions composées pour le collège Louis-le-Grand qui soit conservée. Alors que le musicien en fut le maître de musique pendant plusieurs années, l’on sait peu de choses de sa participation aux somptueuses représentations théâtrales dont le collège s’est fait une spécialit...

  13. La « Nouvelle Mosquée » d’Alger. Le déroulement d’une procédure constructive au xviie siècle

    Directory of Open Access Journals (Sweden)

    Samia Chergui

    2012-01-01

    Full Text Available « La Nouvelle Mosquée » est érigée, à la fin du xviie siècle, dans la seule perspective de doter le rite hanéfite de sa propre Grande Mosquée. Cette nouvelle édification relève, à l’évidence, d’une procédure collective exceptionnelle, celle qu’entreprend la milice d’Alger, en l’occurrence le corps des janissaires, en puisant dans les fonds des Subul al-Khayrât. L’examen du livre de comptes qu’avait tenu cette institution ḥabûs, responsable de la gestion de la plupart des mosquées hanéfites et de leurs awqâf, aussitôt après le lancement du chantier, a permis de suivre le déroulement des travaux sur une période de presque dix années, soit de 1067/1656-1657 à 1076/1665-1666. Ce rôle de chantier apporte des éclairages significatifs notamment sur la nature, la provenance, la quantité et le coût des matériaux employés à la construction. Ils ne manquent pas non plus de documenter les aspects concernant leur fabrication, voire leur préparation, et quelque rares fois leur mise en œuvre ; une mise en œuvre qui, ici, revient à la dextérité de nombreux hommes, mobilisés dans le cadre corporatif. La comptabilité salariale, tenue en cette occasion, compte d’ailleurs parmi les rares initiatives de gestion qui ont permis, durant au moins une décennie, de consigner les plus amples détails non seulement sur le profil distinctif de l’ensemble de ces intervenants, mais également sur leur origine géographique, voire confessionnelle.

  14. La preuve par le nombre

    Directory of Open Access Journals (Sweden)

    Hélène Verdier

    2012-04-01

    Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre lele de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...

  15. La démarche de l’« Ingénierie de la formation » appliquée dans le contexte de la didactique du FLE

    Directory of Open Access Journals (Sweden)

    Nicoleta-Loredana MOROSAN

    2012-12-01

    Full Text Available Le but de cette présentation est de faire le bilan de notre réflexion occasionnée par le stage «Ingénierie de la formation» organisé par le Centre régional francophone pour l’Europe centrale et orientale (CREFECO de l’Organisation Internationale de la Francophonie (OIF et déroulé à Sofia, du 18 au 22 juin 2012. Le séminaire a été cordonné par le formateur français Régis CRISTIN, docteur en sciences du langage. Les participants à ce stage, au nombre de 15, ont été des enseignants de FLE venant de différents établissements d’éducation de cinq pays de l’Europe centrale et orientale, à savoir l’Albanie, l’Arménie, la Bulgarie, la Moldavie et la Roumanie.

  16. Kultuuritehas vallutab vana katlamaja / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2005-01-01

    Kultuuritehase projektijuht Madis Mikkor Tallinna Põhja puiesteel asuva vana elektrijaama tööstusmiljööst ja hoonetest, kuhu kolib kultuuritehas Polymer. Katlamaja plaanitakse avada augustis mitmepäevase festivaliga

  17. Leedu päritolu kasiinoärimees püsib rikkuselt kolmanda ameeriklasena / Erik Aru

    Index Scriptorium Estoniae

    Aru, Erik

    2006-01-01

    Väidetavalt Leedu päritolu kasiinoärimehest Sheldon Adelsonist, tema rivaliteedist Steve Wynniga, nende tegevus Hiina Rahvavabariigi territooriumil Macaos. Lisa: Las Vegas kolib Aasiasse. Tabel : Las Vegas Sands Corporation

  18. Väljak: siseväljak = Square: inner plaza / Kristi Tuurmann, Tiia Vahula, Riin Kersalu, Kerstin Kivila

    Index Scriptorium Estoniae

    Tuurmann, Kristi

    2013-01-01

    EKA arhitektuuri ja linnaplaneerimise osakonna III kursuse 2009-2012 aastail erialase projekteerimise raames loodud lahendus, kus ei teki raekoja ette traditsioonilist väljakut, pigem "kolib" see avaliku ruumina linnavalitsuse sisse

  19. Stravinsky, Igor: Le Sacre du Printemps / Pierre-E. Barbier

    Index Scriptorium Estoniae

    Barbier, Pierre-E.

    1996-01-01

    Uuest heliplaadist "Stravinsky, Igor: Le Sacre du Printemps. Requiem Canticles. Canticum sacrum. Variations sur un choral de Bach. Orchestre de la Suisse Romande, Neeme Järvi" Chandos CHAN 9 408, distribution Media 7 (SD:160F)

  20. [I direttori delle riviste vanno avanti: attenersi ai principi accademici, adottare trasparenza e rispetto e applicare le regole.

    Science.gov (United States)

    Teixeira da Silva, Jaime A; Dobránszki, Judit

    2018-05-01

    Nonostante i cambiamenti in corso nell'ambito delle pubblicazioni scientifiche (STEM - scienza, tecnologia, ingegneria e medicina), è indubbio che i direttori delle riviste restano i più importanti custodi del processo editoriale. In questo articolo vengono analizzati i motivi per cui i direttori delle riviste devono continuare ad attenersi ai principi editoriali fondamentali e a utilizzare le nuove tecnologie digitali solo per dare forza al contenuto, ma non per sostituirlo nella sua qualità. Per raggiungere questo obiettivo, in un'epoca caratterizzata da controlli ed equilibri, i direttori delle riviste devono essere attentamente sorvegliati e ritenuti responsabili tanto quanto gli autori che essi stessi valutano. Qualunque scorciatoia potrebbe avere conseguenze negative e inaspettate per quella rivista che non si attenesse a tali regole, che vedrebbe intaccata la propria reputazione e che dovrebbe faticare per recuperare la fiducia dei propri lettori. Quindi, a rischio di sembrare scontati, è meglio prevenire il danno alla reputazione piuttosto che curarlo. L'unico modo per evitarlo è che i direttori delle riviste si adattino a un crescente movimento sempre più critico, che richiede maggiore trasparenza e responsabilità da parte di chi contribuisce a costruire la base delle conoscenze scientifiche e dalla società, specialmente laddove la ricerca è finanziata pubblicamente.

  1. Reinfarction Following PCI or Medical Management using the Universal Definition in Patients With Total Occlusion After Myocardial Infarction: Results from Long Term Follow up of the OAT Cohort

    Science.gov (United States)

    White, Harvey D.; Reynolds, Harmony R.; Carvalho, Antonio C.; Pearte, Camille A.; Liu, Li; Martin, C. Edwin; Knatterud, Genell L.; Džavík, Vladimír; Kruk, Mariusz; Steg, Philippe Gabriel; Cantor, Warren J.; Menon, Venu; Lamas, Gervasio A.; Hochman, Judith S.

    2014-01-01

    Background The Occluded Artery Trial (OAT) randomized 2201 patients with a totally occluded infarct-related artery on days 3–28 (>24 hours) following myocardial infarction (MI) to percutaneous coronary intervention (PCI) or medical treatment (MED). There was no difference in the primary endpoint of death, reinfarction or heart failure at 2.9 year or 6-year mean follow-up. However in patients randomized to PCI there was a trend for an increase in reinfarction. Methods We analyzed the characteristics and types of reinfarction according to the universal definition. Independent predictors of reinfarction were determined using Cox proportional hazard models with follow up to 9 years. Results There were 169 reinfarctions; 9.4% PCI vs 8.0% MED, HR 1.31, 95% CI 0.97 −1.77, p=0.08. Spontaneous reinfarction (type 1) occurred with similar frequency in the groups; 4.9% PCI vs 6.7% MED, HR 0.78, 95% CI 0.53 – 1.15, p=0.21. Rates of type 2 (secondary) and 3 (sudden death) MI were similar in both groups. There was an increase in type 4a reinfarctions (related to protocol or repeat PCI), 0.8% PCI vs 0.1% MED, p=0.01 and type 4b reinfarctions (stent thrombosis); 2.7% PCI vs 0.6% MED, p<0.001. Multivariate predictors of reinfarction were history of PCI prior to study entry (p=0.001), diabetes (p=0.005), and absence of new Q waves with the index infarction (p=0.01). Conclusions There was a trend for reMI to be more frequent with PCI. Opening an occluded infarct-related artery in stable patients late post-MI exposes them to a risk of subsequent reinfarction related to reocclusion and stent thrombosis. PMID:22520521

  2. Clopidogrel-Proton Pump Inhibitor Drug-Drug Interaction and Risk of Adverse Clinical Outcomes Among PCI-Treated ACS Patients: A Meta-analysis.

    Science.gov (United States)

    Serbin, Michael A; Guzauskas, Gregory F; Veenstra, David L

    2016-08-01

    Uncertainty regarding clopidogrel effectiveness attenuation because of a drug-drug interaction with proton pump inhibitors (PPI) has led to conflicting guidelines on concomitant therapy. In particular, the effect of this interaction in patients who undergo a percutaneous coronary intervention (PCI), a population known to have increased risk of adverse cardiovascular events, has not been systematically evaluated. To synthesize the evidence of the effect of clopidogrel-PPI drug interaction on adverse cardiovascular outcomes in a PCI patient population. We conducted a systematic literature review for studies reporting clinical outcomes in patients who underwent a PCI and were initiated on clopidogrel with or without a PPI. Studies were included in the analysis if they reported at least 1 of the clinical outcomes of interest (major adverse cardiovascular event [MACE], cardiovascular death, all-cause death, myocardial infarction, stroke, stent thrombosis, and bleed events). We excluded studies that were not exclusive to PCI patients or had no PCI subgroup analysis and/or did not report at least a 6-month follow-up. Statistical and clinical heterogeneity were evaluated and HRs and 95% CIs for adverse clinical events were pooled using the DerSimonian and Laird random-effects meta-analysis method. We identified 12 studies comprising 50,277 PCI patients that met our inclusion and exclusion criteria. Our analysis included retrospective analyses of randomized controlled trials (2), health registries (3), claims databases (2), and institutional records (5); no prospective studies of PCI patients were identified. On average, patients were in their mid-60s, male, and had an array of comorbidities, including hyperlipidemia, diabetes, hypertension, and smoking history. Concomitant therapy following PCI resulted in statistically significant increases in composite MACE (HR = 1.28; 95% CI = 1.24-1.32), myocardial infarction (HR = 1.51; 95% CI = 1.40-1.62), and stroke (HR = 1.46; 95

  3. Publications | Page 94 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, ... Le syndrome... Diamants de guerre — pour en finir. L'important accord international sur les diamants conclu cette année ne portera pas fruits s'il n'est pas ...

  4. High-risk PCI: how to define it today?

    Science.gov (United States)

    DE Marzo, Vincenzo; D'Amario, Domenico; Galli, Mattia; Vergallo, Rocco; Porto, Italo

    2018-04-11

    Before the percutaneous spread, the mortality rate of patients with coronary heart disease not suitable for cardiac surgery was markedly high. This limit has been progressively exceeded with the advent of minimally invasive approaches, which, although was initially intended exclusively for low risk patients, was then employed in complex patients often too compromised to undergo cardiac surgery. Given to the rising of high-risk population, due to an increase of patients with multiple chronic conditions linked to the best care offered, we are witnessing an expansion of the high-risk percutaneous coronary interventions (PCI) population. Despite defining what high-risk is remains still unclear, all proposed definitions of high-risk PCI combine features related to three clinical areas: 1) patient risk factors and comorbidities (incorporating those which preclude surgical or percutaneous revascularization such as diabetes, COPD, CKD, lung disease, frailty, advanced age); 2) location of the disease and complexity of coronary anatomy (including multi-vessel disease, left main disease, CTO, bifurcations); 3) hemodynamic clinical status (ventricular dysfunction, concomitant valvular disease or unstable characteristics). Since cardiologists have ascertained the encouraging results in terms of efficacy and rewards compared to the low-risks patients, the important role of treating high-risk patients is becoming more and more relevant to the point that current guidelines have now changed the appropriateness of percutaneous interventions indications. Considering the complexity in managing higher-risk patients with coronary artery disease, the next step to ensure the best care for this type of patients is to create a team-based model of cooperation in order to properly establish the right treatment for the right patient.

  5. La communication participative pour le développement : Un agenda ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    1 janvier 1996. ISBN : Épuisé. 138 pages. e-ISBN : 1552503909. Téléchargez le PDF. Il y a deux ans, le Centre de recherches pour le développement international a créé CIME, un programme de communication pour le développement, afin de témoigner de l'importance des interrelations entre la Communication à la base, ...

  6. Figure culturelle de la puberté: l‘adolescent et le sport

    Directory of Open Access Journals (Sweden)

    Cristina Lindenmeyer

    2015-03-01

    Full Text Available S’il existe un corps qui interroge l’envers de la culture et met à l’épreuve la dynamique pulsionnelle c’est bien le corps pubère. Lieux de transformation et de métamorphoses importantes, le corps pubère bouscule les certitudes infantiles et réactive le complexe d’Œdipe, venant de ce fait interroger le social. Comment l’adolescent s’y prend-il pour supporter cette traversée dans la «tempête»? Le bouleversement pulsionnel met-il en échec la symbolisation de l’adolescent? Quels sont les fantasmes réactivés par la transformation pubertaire? Comment la société prend-elle en compte les modalités subjectives présentes dans cette période? Dans ce texte l’auteur propose une réflexion sur la pratique du sport engagée comme solution de compromis pour négocier avec la dynamique pulsionnelle bouleversée par le ré...

  7. 100 Gbps PCI-Express Readout for the LHCb Upgrade

    CERN Document Server

    Durante, Paolo; Schwemmer, Rainer; Marconi, Umberto; Balbi, Gabriele; Lax, Ignazio

    2015-01-01

    We present a new data acquisition system under development for the next upgrade of the LHCb experiment at CERN. We focus in particular on the design of a new common readout board, the PCIe40, and on the viability of PCI-Express as an interconnect technology for high speed readout. We describe a new high-performance DMA controller for data acquisition, implemented on an FPGA, coupled with a custom software module for the Linux kernel. Lastly, we describe how these components can be leveraged to achieve a throughput of 100 Gbit/s per readout board.

  8. Primary PCI: time to change focus from epicardial reperfusion towards protection of the microvasculature

    NARCIS (Netherlands)

    van Lavieren, Martijn A.; van de Hoef, Tim P.; Piek, Jan J.

    2014-01-01

    Myocardial tissue perfusion remains compromised in 30-40% of patients with ST-segment elevation myocardial infarction (STEMI) despite restored epicardial patency after primary percutaneous coronary intervention (pPCI). This phenomenon is attributed to microvascular dysfunction secondary to numerous

  9. Rebelle De Fatou Keita Ou le Combat Feminin Contre la Patriarchie ...

    African Journals Online (AJOL)

    Le combat féministe est un sujet d'actualité dans une Afrique toujours gouvernée par des systèmes phallocentriques qui emprisonnent la femme ou l'enterrent dans la misère. L'écriture, parmi d'autres moyens, est une arme par excellence utilisée dans le combat contre le système patriarcal. L'écrivaine féministe s'en sert ...

  10. Les porphyres luganais entre le Lac de Lugano et la Valganna

    NARCIS (Netherlands)

    Sitter, de L.U.

    1925-01-01

    Le terrain exploré est limité au Nord par une ligne droite, qui va de Ghirla en passant par Marzio à Brusimpiano. La limite Est est formée par le lago di Lugano et par la vallée de Porto Ceresio jusqu’à Pogliana. La limite Sud est plus irrégulière; elle passe au Sud de Pogliana vers le sommet de la

  11. La science, la littérature, le rituel: le vrai dire et le plus que mentir

    Directory of Open Access Journals (Sweden)

    Panagiotis Christias

    2005-03-01

    Full Text Available Le scientifique promet la vérité sans être en mesure d'accomplir sa promesse tandis que l'écrivain promet de mentir mais par son mensonge, il fait plus que mentir. Il ne dit certainement pas la vérité, car la vérité n'est pas sa préoccupation première. Voilà comment nous pouvons résumer les deux attitudes, condamnées à un antagonisme stérile par l'attitude positiviste moderne. Compte tenu donc de l'intention fondatrice de la science, de sa promesse donc originaire et fondatrice, la science doit dire la vérité et rien que la vérité. Ce qui, de l'aveu même de cette même science, est impossible. [...] La littérature se permet de reconstruire des mondes par-delà le vrai et le faux. [...] Un récit littéraire ne demande pas la consécration de la vérité, ne demande pas à être suivi parce que vrai, n'impose rien et n'attend rien. Sa vraie destinée est l'errance et sa vraie conscience est celle de sa dissémination. Celui qui renonce à la prétention de vérité renonce en même temps à la volonté de dominer. Dominer signifie créer un espace de vérité dans lequel celui qui énonce la vérité est le maître légitime de ceux qui sont dans le champ de la conception du monde dont cette vérité est la pierre angulaire.

  12. [The Effects of Smart Program for Patients Who Underwent Percutaneous Coronary Intervention (SP-PCI) on Disease-Related Knowledge, Health Behavior, and Quality of Life: A Non-Randomized Controlled Trial].

    Science.gov (United States)

    Lee, Jueun; Lee, Haejung

    2017-12-01

    To identify the effects of a smart program for the patients who underwent percutaneous coronary intervention (SP-PCI) on coronary disease-related knowledge, health behaviors, and quality of life. A nonequivalent control group with a non-synchronized design was utilized and 48 participants (experimental=22, control=26) were recruited from a university hospital in Gyeongsang area from May to December, 2016. The 12-week SP-PCI consisted of self-study of health information using smart phone applications (1/week), walking exercise (>5/week) using smart band, feedback using Kakao talk (2/week), and telephone counseling (1/week). Patients in the control group received usual care from their primary health care providers and a brief health education with basic self-management brochure after the PCI. Data were analyzed using the SPSS 21.0 program through descriptive statistics, χ² test, and t-test. After the 12-week SP-PCI, the experimental group showed higher levels of coronary disease-related knowledge (t=2.43, p=.019), heart-related health behaviors (t=5.96, pPCI provided easy access and cost-effective intervention for patients after PCI and improved their knowledge of the disease, performance of health behaviors, and quality of life. Further study with a wider population is needed to evaluate the effects of SP-PCI on disease recurrence and quality of life for patients after PCI. © 2017 Korean Society of Nursing Science

  13. Karastusjoogihiid võib Eestile selja pöörata / Virge Lahe, Artur Tooman

    Index Scriptorium Estoniae

    Lahe, Virge

    2008-01-01

    Coca-Cola kolib kulude optimeerimiseks oma tootmise Tallinnast Lätti. Vt. samas: Õlletehas jätkab Sakus; Farmaatsiatehas võib kolida Riiga; Coca-Cola Hellenic. Diagramm: Coca-Cola majandusnäitajad

  14. Moroz i rozõ / Lev Livshits

    Index Scriptorium Estoniae

    Лившиц, Лев, 1924-2013

    2006-01-01

    Ain Järvega Kadrioru pargist. Kadrioru Lastepargi tekkimise ajaloost ja uue Lastepargi rajamisest. Ehitatakse uus Lastemuuseumi hoone kuhu kolib Kotzebue tänavalt Tallinna Nukumuuseum. Nukumuuseumist ja muuseumidest Kadriorus, ka KUMU hoonest

  15. Le chalutage à vapeur à Lorient (1880-1939

    Directory of Open Access Journals (Sweden)

    Pascal Boisson

    2011-12-01

    Full Text Available En France, à la différence de l’Angleterre et de l’Allemagne, l’industrie du chalutage à vapeur reste longtemps stationnaire. A Lorient, l’arrivée du chalutage à vapeur date de la fin du XIXe siècle. Comment analyser son développement, principale innovation halieutique, sinon comme un levier du développement portuaire et charbonnier? En effet, le chalutage nécessite des aménagements portuaires, la mise en place de liaisons ferroviaires de trains de marée, qui contribuent ainsi à créer un arrière-pays et à développer les importations de charbon. Grâce au chalutage, Lorient, comme La Rochelle et Saint-Malo, connaît un renouveau économique. Au lendemain de la Première Guerre mondiale, la France a un besoin urgent de trois ou quatre ports de pêche spécialisés. Lorient, présentant de nombreux atouts, bénéficie des mannes de l’Etat pour la construction d’un gigantesque complexe portuaire opérationnel en 1927: le port de pêche de Kéroman, incontestable réussite économique. Dès 1929, la flotte des chalutiers à vapeur est progressivement remplacée par des navires motorisés. A la veille de la Seconde Guerre mondiale, 68% des chalutiers fonctionnent au moteur Diesel. Fait remarquable, le modèle lorientais offre l’exemple original d’un développement d’une industrie du chalutage à vapeur, précisément parce que les gens de mer n’y ont joué aucun rôle primordial; ce sont les industriels du charbon, notamment Emile Marcesche, et les compagnies de chemin de fer qui assurent le développement et la montée en puissance de cette nouvelle industrie pour le port de Lorient.

  16. The Italian Lightning Detection System of CESI and its applications; Il sistema italiano di rilevamento fulmini del CESI e le sue applicazioni

    Energy Technology Data Exchange (ETDEWEB)

    Iorio, R. [CESI Centro Elettrotecnico Sperimentale Italiano, Milan (Italy)

    1998-03-01

    Aim of the paper is to give a description of the CESI lightning detection system SIRF. The system allows the real time localization (latitude, longitude) of the striking point of a cloud-to-ground lightning flash. Electrical parameters of the impulsive currents related to the flash strokes are calculated as well. Based on sensors covering the whole Italian territory, SIRF configuration and of the basic calculation criteria for passing from the sensor raw data to the final flash data is given together with the evaluation of the system expected performance parameters (accuracy, detection efficiently, signal/noise ratio). Main uses of lightning data in several fields are then reported, with special reference to electrical applications. Mention is done about the different modalities adopted for data distribution, according to that either real time or passed time applications have to be carried out. In this latter case (e.g. statistics), a huge amount of data archived within the Lightning Data Base of SIRF is available. [Italiano] Oggetto della memoria e` la descrizione del Sistema Italiano Rilevamento Fulmini del CESI, denominato SIRF, unico sistema attualmente esistente in Itallia in grado di localizzare in tempo reale e su tutto il territorio nazionale i punti di impatto di fulmini di tipo nube-suolo e le caratteristiche principali delle correnti impulsive ad essi associate. Vengono quindi riportati una descrizione della rete nella sua configurazione attuale ed i suoi collegamenti con le reti di Paesi confinanti (Francia, Svizzera, Austria). Si accenna ai criteri alla base dei calcoli dei dati finali di fulmine, a partire dai dati rilevati dai sensori, e si riportano i valori stimati dei tipici parametri di valutazione delle prestazioni di un sistema di rilevamento fulmini (precisione, efficacia di rilevamento, rapporto segnale/disturbo). Sono successivamente descritte le principali applicazioni dei dati di fulmine nei vari settori, con particolare riferimento al

  17. Independent Predictors of Bleeding Complications in Patients Undergoing PCI With Concomitant Treatment With Bivalirudin in Clinical Practice Results From the Improver Registry

    DEFF Research Database (Denmark)

    Koeth, Oliver; Gulba, Dietrich; Huber, Kurt

    2013-01-01

    Bleeding complications are associated with an adverse outcome after a percutaneous coronary intervention (PCI) is performed. Traditional risk factors for bleeding complications are age, gender, underweight, hypertension, and renal impairment. The aim of our study was to identify the independent...... predictors of bleeding complications in patients undergoing a PCI with concomitant treatment with bivalirudin....

  18. Denissen (Frans), André Baillon. Le gigolo d’Irma Idéal

    OpenAIRE

    Gnocchi, Maria Chiara

    2012-01-01

    Un titre aux résonances insolites vient chatouiller la règle sobre des Archives du Futur, la collection publiée sous la responsabilité des Archives et Musée de la Littérature de Bruxelles. André Baillon. Le gigolo d’Irma Idéal : un titre qui convient bien à une biographie que l’on a déjà — à juste titre — qualifiée d’extra-ordinaire (F. Ghysen, Le Carnet et les Instants, novembre 1998). Extra-ordinaire est d’ailleurs, avant tout, le protagoniste du volume : Baillon le grand écrivain, Baillon ...

  19. The Concept of Data Collection and Processing System for Audit according to the PCI DSS

    Directory of Open Access Journals (Sweden)

    D. N. Makrushin

    2011-12-01

    Full Text Available The objects of the research are verification procedures meet the requirements of the standard of the documents supporting the information security standard in the payment card industry (PCI DSS.

  20. Documenter le futur: fantasmes, projections et decalages spatiotemporels

    Directory of Open Access Journals (Sweden)

    Alice Forge

    2015-10-01

    Full Text Available Le concept de documentation future recèle un paradoxe : le mot documenter renvoie à des traces relevées dans un passé factuel, tandis que le futur ne peut, par définition, être qu’incertain, que l’objet de fantasmes, de projections. L’analyse suivante questionne ce paradoxe à travers l’analyse d’un motif cinématographique : un homme et une femme face à une tranche de séquoia, représentation symbolique du temps. Ce motif apparait dans trois oeuvres majeures du cinéma : Vertigo, d’Alfred Hitchcock, La Jetée de Chris Marker, et l’Armée des douze singes, de Terry Gilliam. La répétition de ce motif est mise en rapport avec l’ouvrage de Pierre Bayard, Le plagiat par anticipation, afin de l’envisager sous l’angle du paradoxe temporel, plutôt que sous le régime de la chronologie historique. Cette analyse prend pour point de départ une oeuvre intitulée Vozes Fantasmas, qui sur le principe de la documentation future propose d’écouter des murmures de spectateurs visitant une exposition qui n’a pas eu lieu. RESUMO O conceito de documentação do futuro evoca um paradoxo: o verbo documentar refere-se a traços ou rastros preservados de um passado factual, enquanto o futuro por definição é algo incerto, objeto de especulações, fantasias e projeções. Nossa reflexão questiona este paradoxo a partir da análise de uma cena cinematográfica: um homem e uma mulher em frente de um corte de sequoia, que é a representação simbólica do tempo. Esta cena aprece em três grandes obras do cinema: Vertigo (Um corpo que cai de Alfred Hitchcock, La Jetée de Chris Marker, e Os Doze Macacos de Terry Gilliam. A repetição desta cena é abordada em relação à obra de Pierre Bayard, Plágio por antecipação, a fim de considerá-la em termos de paradoxo temporal, e não como uma cronologia histórica. Esta análise tem como ponto de partida um trabalho artístico intitulado Vozes Fantasmas, que seguindo o princípio de

  1. La 44e élection présidentielle américaineLe regard des Américains dans un contexte mondial difficile

    Directory of Open Access Journals (Sweden)

    Cynthia Ghorra-Gobin

    2008-11-01

    Full Text Available La 44e élection présidentielle américaine qui a commencé début janvier dans l’Etat de l’Iowa vient de se traduire par la victoire de Barack H. Obama, un candidat démocrate au parcours atypique.  Ce dernier a remporté 364 Grands Electeurs contre 174 pour son adversaire, le candidat républicain John McCain, soit une avance de 190 points. Aux Etats-Unis, le vote des Grands Electeurs (dont le nombre au sein de chacun des 50 Etats varie en fonction du poids démographique est en effet décisif pour...

  2. Le contrôle de gestion des entreprises familiales : un contrôle non-financiarisé ?

    OpenAIRE

    Barbelivien , Dominique

    2016-01-01

    Nous examinons la tendance décrite dans la littérature quant à la financiarisation de la fonction de contrôle de gestion en nous appuyant sur le cas d’une entreprise de taille intermédiaire familiale. Nous constatons que le contrôle de gestion dans le cas étudié correspond à une rationalisation des décisions opérationnelles et développons les raisons qui peuvent expliquer la persistance d’un contrôle de gestion très opérationnel. Le contexte d’entreprise familiale dans laquelle il y a confusi...

  3. Enseñar literatura a estudiantes de E/LE. ¿Cómo diseñar un curso de Introducción a la literatura española?

    Directory of Open Access Journals (Sweden)

    Marta Plaza Velasco

    2012-08-01

    Full Text Available La literatura es un recurso muy útil en el aula de E/LE: no solo nos permite trabajar determinados contenidos gramaticales, funcionales o léxicos, sino también acercar a nuestros alumnos y alumnas a las culturas e historias de España y Latinoamérica al mismo tiempo que ejercitan su imaginación y creatividad. Es por esto que podemos encontrar muchos materiales didácticos y estudios teóricos relacionados con la utilización de la literatura en el aula de E/LE. Pero, ¿qué ocurre cuando de lo que se trata no es de utilizar la literatura para enseñar español sino de enseñar literatura a estudiantes de E/LE? El material y los estudios teóricos que encontramos sobre esta cuestión no son tan abundantes.

  4. Magic turtle dans le canton du Jura: concept marketing

    OpenAIRE

    Hauser, Magali; Perruchoud-Massy, Marie-Françoise

    2012-01-01

    Depuis juin 2009, Saint-Ursanne/Clos du Doubs est une région pilote du Projet Enjoy Switzerland/ASM ayant pour but d’intervenir sur le développement et la sensibilisation du tourisme dans la région. En parallèle, la Maison du Tourisme, entreprise proposant principalement des offres touristiques dans la région, a ouvert ses portes l’année dernière. Ces deux entités ont travaillé ensemble afin de développer une nouvelle offre touristique intitulée « Magic turtle ». Le Magic turtle, pensé par de...

  5. Le monde quantique

    CERN Document Server

    Aspect, A; Bensaude-Vincent, B; Castiel, A; Chevalley, C; Darrigol, O; Deligeorges, S; D'Espagnat, B; Laloë, F; Lévy-Leblond, J-M; Messiah, A; Paty, M; Vuillemin, J; Wheaton, B R

    1984-01-01

    Le monde quantique La physique quantique, après trois quarts de siècle, n'en finit pas d'être moderne. Elle est présente quotidiennement dans les laboratoires où les physiciens étudient atomes, noyaux et particules. Elle est entrée dans l'industrie où lasers, transistors et supraconducteurs lui doivent d'exister. Et elle continue à alimenter le débat philosophique sur la nature de la réalité dont elle montre la non-séparabilité fondamentale. Ses concepts de base, son développement, ses applications, ses controverses sont ici présentés par une pléiade de physiciens, d'historiens et de philosophes.

  6. Un lieu saint et ses représentations : le Yaudet

    OpenAIRE

    Provost, Georges

    2005-01-01

    Cet article cherche à montrer comment a évolué, entre le début du XVIIe siècle et la fin du XXe siècle, la perception mentale d’un site archéologique et religieux : le Yaudet en Ploulec’h (Côtes-d’Armor), forteresse proto-historique et romaine abandonnée à partir du Moyen Âge mais relayée par un pèlerinage à la Vierge. Au fil des siècles, le Yaudet a été tantôt présenté comme le premier foyer de l’évangélisation chrétienne de la Bretagne ; comme un lieu de culte païen christianisé ; comme le ...

  7. Patient awareness of stent type, risk of cardiac events, and symptoms of myocardial infarction among PCI patients: a missed educational opportunity?

    Science.gov (United States)

    D'Elia, Alexis A; Hafiz, Abdul Moiz; Naidu, Srihari S; Marzo, Kevin P

    2011-04-01

     Timely and successful treatment of myocardial infarction (MI) requires accurate recognition by the patient of the signs and symptoms. As patients who have undergone percutaneous coronary intervention (PCI) remain at risk for cardiac events, it is important that they have a basic understanding of their cardiac status.  We surveyed 80 consecutive patients following elective PCI using a simple multiple-choice questionnaire. Type of stent (bare metal or drug-eluting), how they perceive the procedure would affect their cardiovascular health, their perceived risk of a future MI, and whether they recalled specific education on how to recognize symptoms of an MI were queried.  45% (n = 36) of patients were unaware of stent type. 10% stated PCI was performed to relieve symptoms of angina, 30% (n = 24) stated it would prevent MI, 56.3% (n = 45) stated that it would both prevent MI and reduce symptoms of angina, while 3.8% stated it would do neither. 86.3% (n = 69) stated they remained at risk for MI despite the procedure. However, 42.5% (n = 34) of patients did not perceive to have received specific education on the signs and symptoms of MI during their hospital stay.  Patient understanding of stent type, expected cardiovascular outcomes, and recognition of MI post-PCI appears low in the real-world setting. A systematic approach to post-PCI education should be incorporated into routine care, in order to capitalize on the educational opportunity afforded by this high risk population. ©2010, Wiley Periodicals, Inc.

  8. Publications | Page 17 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... facteurs de violence liée au sexe en milieu urbain au Pakistan. Dans les centres urbains au Pakistan, le sexe et la violence interagissent de manière inattendue et influencent profondément la vie des femmes et des hommes, comme le démontre une étude menée à Karachi par l'Institute of Business Administration.

  9. Mettre fin à la violence sexuelle et fondée sur le sexe : de l'idée à l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    10 nov. 2015 ... Inde : Le gouvernement indien a mis sur pied un comité spécial de trois membres avec l'objet de recommander des modifications aux lois criminelles du pays qui régissent les cas d'agression sexuelle. Les témoignages de près d'une dizaine de chercheurs appuyés par le CRDI ont aidé le comité à dicter ...

  10. Long-term mortality after primary PCI for STEMI in patients with insulin-dependent diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Zlatanović Petar

    2015-01-01

    Full Text Available Introduction: Primary PCI (pPCI is the gold standard in the treatment of patients with acute myocardial infarction (AMI with ST elevation (STEMI. Aim: The purpose of this study is to evaluate the influence of diabetic status upon arrival at five year survival in patients with STEMI that were treated with pPCI. Material and methods: Consecutive data for 2087 patients admitted in the period from 1st of January 2009. to 31st of December 2010. with diagnosis of acute STEMI were collected from catheterisation laboratory cardiology clinic CCS electronic database. Patients were divided into 3 groups: those without diabetes mellitus (DM, IDDM (insulin dependent diabetes mellitus, NIDDM (non-insulin dependent diabetes mellitus. Results: 1664 patients (79.7% did not have DM, 98 (4.7% had IDDM and 325 (15.6% had NIDDM. There was a statistically significant difference in mortality rate among three groups after 30 days, one year and five years after intervention, and the highest rates were recorded at the IDDM patients, then at the NIDDM and the lowest in patients without DM (15.3% vs 8.3% vs 5.9 %, p < 0.001 after 30 days; 21.4% vs 15.4% vs 10.9%, p < 0.001 after one year and 32.7% vs 24.3% vs 18%, p < 0.001 after 5 years. Also, there was a highly statistically significant difference in five-year mortality rate between patients with and without DM (26.2 % vs 17.6%, p < 0.001. IDDM was a independent factor when it comes to predicting five-year mortality (HR = 1.58, 95% CI 1.07-2.32, p = 0.02 whereas NIDDM was not (HR = 1.24, 95% CI 0.95-1.63, p = 0.12. Conclusion: Diabetic patients had an increased risk of mortality in the short and long-term follow-up after pPCI. Insulin-dependent was a single predicting factor after five year follow-up.

  11. Relever le défi d'analyse statistique dans des études en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI et Cancer Research UK lancent une nouvelle initiative contre le tabagisme. Le CRDI et Cancer Research UK ont le plaisir d'annoncer le lancement d'une nouvelle initiative d'une durée de cinq ans visant la prévention des maladies liées au tabagisme. Voir davantageLe CRDI et Cancer Research UK lancent une ...

  12. E-books for Italian school, between Law Requirements and Publishers' Choices L'ebook per le scuole italiane fra requisiti normativi e scelte editoriali

    Directory of Open Access Journals (Sweden)

    Maria Vincelli

    2011-12-01

    Full Text Available

    Il saggio presenta un'analisi del quadro legislativo italiano sulla transizione dei libri di testo dal formato cartaceo a quello digitale, oltre a una panoramica sull'offerta dei maggiori editori a riguardo, prendendo come esempio i libri di testo di Latino per le scuole superiori. Il concetto di libro digitale viene declinato oggi principalmente in due forme: il libro "on-line", digitale (generalmente in PDF o Epub, equivalente ai testi tradizionali a stampa per struttura e tipo di utilizzo; il libro che integra le caratteristiche del libro sia digitale che a stampa con una serie di materiali digitali supplementari. L'opinione dell'autrice è che l'offerta di pubblicazioni scolastiche in formato digitale si attiene a un'interpretazione limitata della legge italiana, e che dunque si prospettano nuove ipotesi che possano unire in modo efficace l'autorevolezza e il valore culturale dei libri di testo con le soluzioni più avanzate del digitale.

    This paper offers an analysis of the Italian legislation about the transition from printed school-books to digital ones and, in turn, it presents an overview of the digital publishing offer of major media groups, by taking as case study the Latin textbooks for high-schools. The concept of digital book has been declined nowadays in two main forms: the first one is the so-called "on-line book", which are digital books (typically in PDF or ePub format equivalent in structure and in the mode of use to classical printed books; the latter form integrates printed or digital books with a set of varied, and often incoherent, supplementary digital materials. The conclusion is that the current offer of digital publishing about school-books is a narrow interpretation of the Italian legislation, and thus it foresees the design of new paradigms that efficaciously merge the authoritativeness and cultural value of school-books with the advanced features and the new way of uses of digital media.

  13. Design and Rationale for the Endothelin-1 Receptor Antagonism in the Prevention of Microvascular Injury in Patients with non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention (ENDORA-PCI) Trial.

    Science.gov (United States)

    Liou, Kevin; Jepson, Nigel; Buckley, Nicolas; Chen, Vivien; Thomas, Shane; Russell, Elizabeth Anne; Ooi, Sze-Yuan

    2016-04-01

    Peri-procedural myocardial infarction (PMI) occurs in a small but significant portion of patients undergoing percutaneous intervention (PCI). The underlying mechanisms are complex and may include neurohormonal activation and release of vasoactive substances resulting in disruption of the coronary microcirculation. Endothelin in particular has been found in abundance in atherosclerotic plaques and in systemic circulation following PCI, and may be a potential culprit for PMI through its action on microvascular vasoconstriction, and platelet and neutrophil activation. In this study we aim to characterize the behavior of the coronary microcirculation during a PCI with the index of microvascular resistance (IMR) and the effect of peri-procedural endothelin antagonism. The ENDORA-PCI trial is a randomized, double-blind, placebo-controlled, single-center clinical trial designed to evaluate the efficacy of endothelin antagonism in attenuating the peri-procedural rise in IMR as a surrogate marker for PMI. The patients of interest are those with non-ST elevation acute coronary syndrome (NSTEACS) undergoing PCI, and we aim to recruit 52 patients overall to give the study a power of 80 % at an α level of 5 %. Patients will be randomized in a 1:1 fashion to either Ambrisentan, an endothelin antagonist, or placebo, prior to their PCI. IMR will be measured before and after PCI. The primary endpoint is the difference in peri-procedural changes in patients' IMR between the two groups. The ENDORA-PCI study will investigate whether endothelin antagonism with Ambrisentan attenuates the peri-procedural rise in IMR in patients with NSTEACS undergoing PCI, and thus potentially the risk of PMI.

  14. Le Havre, Berlim, Jersalém: a cartografia do mundo

    Directory of Open Access Journals (Sweden)

    Sylvaine Bulle

    2005-07-01

    Full Text Available Por ocasião de uma exposição de fotos de três cidades (Le Havre, Berlim e Jerusalém, o artigo discute as culturas urbanas e os modos de representação e exposição de fatos urbanos modernos. Como vincular séries de imagens para que se tornem legíveis os enunciados políticos e a memória das cidades diante desses fatos? A análise das imagens de cidades no contexto da guerra (Jerusalém e da reconstrução (Berlim, Le Havre remete à produção de culturas urbanas e de arquiteturas entre uma memória local e os fluxos internacionais.Taking an exhibition of photos of three cities (Le Havre, Berlin and Jerusalém as a guideline, the article discusses urban cultures and possibilities of representation and exhibition of modern urban events. How to associate series of images in order to clarify political propositions and the memory of cities in face of these events? The analysis of images of cities in context of war (Jerusalém and of reconstruction (Berlin, Le Havre refers to the production of urban cultures and architectures between local memory and international flows.

  15. Publications | Page 64 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Un projet financé par le CRDI a contribué à abolir les barrières entre la pratique de la recherche-action participative et la formation et la pensée universitaires sur le terrain. Le projet a aussi encouragé des intervenants du Sud à exercer un leadership au regard de communautés régionales et thématiques de praticiens se ...

  16. Publications | Page 65 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Un projet financé par le CRDI a contribué à abolir les barrières entre la pratique de la recherche-action participative et la formation et la pensée universitaires sur le terrain. Le projet a aussi encouragé des intervenants du Sud à exercer un leadership au regard de communautés régionales et thématiques de praticiens se ...

  17. le des coopératives dans le fonctionnement du bassin de collecte laitier du Tadla, Maroc

    OpenAIRE

    Le Gal , P.-Y.; Oudin , E.; Kuper , M.; Moulin , C.-H.; Sraïri , T.

    2007-01-01

    International audience; Le bassin de collecte laitier situé sur le périmètre du Tadla se structure autour d'une usine de transformation industrielle approvisionnée par une myriade de petits éleveurs. Cette atomisation de l'offre a rendu nécessaire la mise en place de coopératives de collecte chargées d'agréger l'offre et d'assurer la chaîne du froid au plus près des producteurs. De fait, ces coopératives jouent un rôle central d'intermédiaire dans la chaîne d'approvisionnement allant de l'eau...

  18. Le discours scientifique sur la scène britannique : lecture croisée d’On Ego de Mick Gordon et A Disappearing Number de Simon McBurney

    OpenAIRE

    campos , liliane

    2009-01-01

    International audience; Simon McBurney et Mick Gordon ont tous deux cherché à présenter la rencontre du théâtre et des sciences comme le résultat d’affinités évidentes. Gordon, qui a créé ce qu’il appelle des « essais théâtraux » en collaboration avec le neurologue Paul Broks, parle d’un « langage commun » à la neurologie et au théâtre, qui nourrit l'expérience de pensée théâtralisée qu'est le spectacle On Ego. McBurney, qui s’est inspiré de la neurologie et des mathématiques, insiste égaleme...

  19. PCI fuel failure analysis: a report on a cooperative program undertaken by Pacific Northwest Laboratory and Chalk River Nuclear Laboratories

    International Nuclear Information System (INIS)

    Mohr, C.L.; Pankaskie, P.J.; Heasler, P.G.; Wood, J.C.

    1979-12-01

    Reactor fuel failure data sets in the form of initial power (P/sub i/), final power (P/sub f/), transient increase in power (ΔP), and burnup (Bu) were obtained for pressurized heavy water reactors (PHWRs), boiling water reactors (BWRs), and pressurized water reactors (PWRs). These data sets were evaluated and used as the basis for developing two predictive fuel failure models, a graphical concept called the PCI-OGRAM, and a nonlinear regression based model called PROFIT. The PCI-OGRAM is an extension of the FUELOGRAM developed by AECL. It is based on a critical threshold concept for stress dependent stress corrosion cracking. The PROFIT model, developed at Pacific Northwest Laboratory, is the result of applying standard statistical regression methods to the available PCI fuel failure data and an analysis of the environmental and strain rate dependent stress-strain properties of the Zircaloy cladding

  20. “Il Risorgimento in scena. Le donne in mostra”

    Directory of Open Access Journals (Sweden)

    Francesco Muollo

    2013-01-01

    Full Text Available Questo paper nasce in seguito alla raccolta dei lavori del convegno “IL RISORGIMENTO IN SCENA. LE DONNE IN MOSTRA”. Ciascuna delle tre giornate che hannoarticolato il convegno, sono dedicate al protagonismo femminile nel Risorgimento, rappresentate dal cinema, dalla danza e dall’ arte. Le arti figurative e sceniche hanno saputo, forse meglio dei libri, preservare la memoria delle donne che hanno fatto l’Italia.

  1. Gender, TIMI risk score and in-hospital mortality in STEMI patients undergoing primary PCI: results from the Belgian STEMI registry.

    Science.gov (United States)

    Gevaert, Sofie A; De Bacquer, Dirk; Evrard, Patrick; Convens, Carl; Dubois, Philippe; Boland, Jean; Renard, Marc; Beauloye, Christophe; Coussement, Patrick; De Raedt, Herbert; de Meester, Antoine; Vandecasteele, Els; Vranckx, Pascal; Sinnaeve, Peter R; Claeys, Marc J

    2014-01-22

    The relationship between the predictive performance of the TIMI risk score for STEMI and gender has not been evaluated in the setting of primary PCI (pPCI). Here, we compared in-hospital mortality and predictive performance of the TIMI risk score between Belgian women and men undergoing pPCI. In-hospital mortality was analysed in 8,073 (1,920 [23.8%] female and 6,153 [76.2%] male patients) consecutive pPCI-treated STEMI patients, included in the prospective, observational Belgian STEMI registry (January 2007 to February 2011). A multivariable logistic regression model, including TIMI risk score variables and gender, evaluated differences in in-hospital mortality between men and women. The predictive performance of the TIMI risk score according to gender was evaluated in terms of discrimination and calibration. Mortality rates for TIMI scores in women and men were compared. Female patients were older, had more comorbidities and longer ischaemic times. Crude in-hospital mortality was 10.1% in women vs. 4.9% in men (OR 2.2; 95% CI: 1.82-2.66, pdiscrimination and calibration in women as well as in men (c-statistic=0.84 [95% CI: 0.809-0.866], goodness-of-fit p=0.53 and c-statistic=0.89 [95% CI: 0.873-0.907], goodness-of-fit p=0.13, respectively), but mortality prediction for TIMI scores was better in men (p=0.02 for TIMI score x gender interaction). In the Belgian STEMI registry, pPCI-treated women had a higher in-hospital mortality rate even after correcting for TIMI risk score variables. The TIMI risk score was effective in predicting in-hospital mortality but performed slightly better in men. The database was registered with clinicaltrials.gov (NCT00727623).

  2. Le soluzioni di logistica urbana sono sostenibili? L'esempio di Cityporto

    Directory of Open Access Journals (Sweden)

    Jesus Gonzalez-Feliu

    2010-07-01

    Full Text Available La logistica urbana è un campo di riflessione volto ad approfondire le soluzioni ottimali per la distribuzione delle merci in ambito urbano e i relativi obiettivi ambientali. Ad oggi, molte azioni sono state intraprese dalle pubbliche autorità senza tenere conto, tuttavia, degli impatti che i nuovi schemi organizzativi possono avere sull’ attuale organizzazione delle imprese. Il contributo incentra la riflessione sul caso studio relativo alla città di Padova, in Italia: il sistema di logistica urbana CityPorto. In particolare, se ne analizzano le caratteristiche dal punto di vista della sostenibilità del sistema proposto, sia in riferimento alla dimensione imprenditoriale che a quella collettiva, mettendo in relazione le peculiarità della logistica urbana e le più estese catene distributive, di scala globale, di cui le prime sono parte integrante.

  3. La gentrification et ses pionniers : lele des artistes off en question

    Directory of Open Access Journals (Sweden)

    Elsa Vivant

    2008-09-01

    Full Text Available Cet article propose d’évaluer lele des artistes, et plus particulièrement des squats d’artistes, dans la gentrification. La littérature anglo-saxonne insiste en effet beaucoup sur lele déterminant de l’arrivée d’artistes plus ou moins marginaux (ceux de la scène dite off dans le déclenchement de la gentrification d’un quartier. Ces artistes sont considérés non seulement comme des initiateurs de la revalorisation symbolique des quartiers qu’ils investissent, mais aussi comme des ferments d’un changement d’ambiance qui permettrait l’arrivée de gentrifieurs plus aisés. Cet article met à l’épreuve ce schéma explicatif à partir de l’étude du cas de Belleville à Paris. Il mobilise pour ce faire deux enquêtes, l’une sur le rapport à leur quartier des habitants de deux rues particulièrement gentrifiées, l’autre sur le marché immobilier. Il apparaît que les artistes sont plus des témoins ou des indicateurs de la gentrification que des déclencheurs ou des catalyseurs. Ils sont partie prenante d’un mouvement de revalorisation de la centralité et de ses ressources (notamment culturelle qui les dépassent. Ce mouvement les dépasse d’autant plus que l’éthique « artiste » s’est largement diffusée dans toutes les couches de la société.This article aims at reassessing the role of artists, and more specifically the role of squatters in the gentrification process. The Anglo-American literature argues that artists influx, especially the underground ones (that we call off, is the key element to trigger the gentrification process in a neighbourhood. These artists are considered as pioneers of the symbolic revalorisation process and as the agent of atmosphere change that brings wealthier gentrifiers to settle down. This article reassesses this scheme, based on the case of Belleville neighbourhood in Paris. It relies on two pieces of researches.  The first one analyses the inhabitants

  4. Optical coherence tomography guided PCI – Initial experience at Apollo Health City, Jubilee Hills, Hyderabad

    Directory of Open Access Journals (Sweden)

    Pratap Chandra Rath

    2014-01-01

    Conclusion: OCT makes better visualization of plaque, thrombus, stent malapposition, dissection, plaque prolapse and helps in optimization of PCI results. More extensive, long-term studies will be needed to assess the prognostic implications of these findings.

  5. L’interface Habitat / Habitant : quand le lieu de vie est porteur de maladie - Le cas du radon en PACA

    Directory of Open Access Journals (Sweden)

    Cissé E.

    2012-10-01

    Full Text Available Les préoccupations sont croissantes pour étudier les liens entre des conditions environnementales spécifiques et la fréquence de certaines pathologies. Nous proposons d’analyser ici le lien présupposé entre une exposition au radon et le cancer du poumon. Le radon, est un gaz radioactif d’origine naturelle (issu de la désintégration naturelle de l’uranium présent dans la croûte terrestre et plus particulièrement dans certaines formations géologiques. A partir du sol et de l’eau, le radon se diffuse dans l’air (exhalation et se trouve, par effet de confinement, à des concentrations plus élevées à l’intérieur des bâtiments qu’à l’extérieur. Les descendants solides du radon sont alors inhalés avec l’air respiré et se déposent dans le poumon. Il est établi par diverses études scientifiques que le radon a un impact non négligeable sur certains cancers, notamment du poumon (augmentation de 16 % du risque de cancer du poumon par tranche de 100 Bq/m3, et des cancers digestifs via la consommation d’eau qui s’est chargée en radon au contact du socle. Le nombre annuel de décès par cancer du poumon attribuable à l’exposition domestique au radon en France métropolitaine varie entre 1 200 à 3 575 en fonction des relations exposition-réponse utilisées. Plusieurs régions en France se caractérisent par une problématique radon reconnue et étudiée depuis longtemps (Bretagne, Massif central, Corse. Or, si le radon ne recouvre pas l’ensemble de la région PACA, certaines zones géographiques sont particulièrement concernées et méritent d’être étudiées : le Massif des Maures dans le Var, du Mercantour dans les Alpes-Maritimes et du Briançonnais dans les Hautes-Alpes. La région PACA est une des régions de France et d’Europe les plus touchées par la pollution atmosphérique principalement due à l’augmentation du trafic routier et des contributions de régions industrialisées telles que

  6. La spermiation chez le brochet.

    Directory of Open Access Journals (Sweden)

    DE MONTALEMBERT G.

    1980-01-01

    Full Text Available L'évolution quantitative et qualitative de la production de sperme au cours de la période de spermiation a été étudiée chez des brochets maintenus en captivité dans un étang de 400 m2. Le sperme est prélevé toutes les semaines à partir du début de février, et pendant près de 2 mois. La quantité de sperme recueillie est très faible et présente de fortes variations individuelles ; elle augmente progressivement jusqu'à la 5me semaine et décroit ensuite. La quantité moyenne de sperme récoltée par mâle est de l'ordre de 0,7 ml/semaine et varie considérablement d'un mâle à l'autre (0.07 à 1,5 ml. La concentration du sperme en spermatozoïdes varie entre 18 et 25 milliards par ml ( X = 21,5 109 + 2,11. La quantité de spermatozoïdes récoltée par semaine est de 28,5 106 + 26,4/kg de poids corporel. La qualité du sperme appréciée par l'intensité et la durée de motilité suit une évolution similaire à celle de la quantité de sperme récoltée avec des valeurs maximales à 4 semaines et minimales en début et fin de période de prélèvement. Les premières ovulations détectées sur des femelles stockées dans les mêmes conditions que les mâles ont été observées à la 6me semaine de prélèvements alors que les performances de spermiation avaient déjà fortement déclinées. Il est vraisemblable que les conditions expérimentales particulièrement traumatisantes pour les mâles ont affecté prématurément la spermiation, amplifiant ainsi le décalage fréquemment observé entre les périodes de spermiation et d'ovulation.

  7. The Reverend Billy Graham: The Preacher in American Politics Le Révérend Billy Graham: Le prêcheur de la politique américaine

    Directory of Open Access Journals (Sweden)

    Stephen Whitfield

    2011-03-01

    Full Text Available Au cours du dernier demi-siècle, aucune personnalité n’a été admirée avec autant de constance par ses concitoyens Américains que le Révérend Billy Graham. Démocrate, on l’associe pourtant plus volontiers à deux présidents républicains : Richard M. Nixon et George W. Bush. La présidence de Nixon fut sanctifiée par les conseils spirituels que Graham prodiguait ouvertement (mais aussi par ses conseils politiques plus confidentiels. Quant à George W. Bush, il incarne le fils prodigue : c’est l’ivrogne, le vaurien que Graham a réussi à rediriger vers le Christ, rendant ainsi possible son étonnante ascension politique. Le fort impact de cet évangéliste sur la politique des Etats-Unis et le fait que Graham soit si intimement associé aux deux présidents les plus controversés des cinquante dernières années seront au centre de notre réflexion.

  8. : tous les projets | Page 459 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... et offrir une formation en méthodes et techniques de recherche en sciences sociales destinée à de jeunes intellectuels et réaliser des recherches sur le terrain afin d'examiner lele que joue la religion sur le plan politique en Iraq (la concurrence entre Nadjaf, en Iraq et Qom, en Iran), et la gouvernance régionale en Iraq, ...

  9. Économie | Page 27 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'Inde s'est lancée dans un train de réformes au milieu des années 1980. ... (la mondialisation) et le relâchement des mesures de contrôle internes ont sans nul ... Ce livre révèle les voies par lesquelles l'innovation en matière de gestion des ...

  10. Measurements of Mode Converted Ion Cyclotron Wave with Phase Contrast Imaging in Alcator C-Mod and Comparisons with Synthetic PCI Simulations in TORIC

    International Nuclear Information System (INIS)

    Tsujii, N.; Porkolab, M.; Edlund, E. M.; Lin, L.; Lin, Y.; Wright, J. C.; Wukitch, S. J.

    2009-01-01

    Mode converted ion cyclotron wave (ICW) has been observed with phase contrast imaging (PCI) in D- 3 He plasmas in Alcator C-Mod. The measurements were carried out with the optical heterodyne technique using acousto-optic modulators which modulate the CO2 laser beam intensity near the ion cyclotron frequency. With recently improved calibration of the PCI system using a calibrated sound wave source, the measurements have been compared with the full-wave code TORIC, as interpreted by a synthetic diagnostic. Because of the line-integrated nature of the PCI signal, the predictions are sensitive to the exact wave field pattern. The simulations are found to be in qualitative agreement with the measurements.

  11. Le khatchkar ou la construction de sa petite Arménie.

    Directory of Open Access Journals (Sweden)

    Marie-Blanche Fourcade

    2007-03-01

    Full Text Available « C’est une reproduction d’un khatchkar que mon fils m’a rapporté d’Arménie. Je l’ai mis dans un endroit choisi pour moi, c’est comme une communion avec l’Arménie » disait Vichen lors d’un entretien que je menais sur le patrimoine domestique de la diaspora arménienne au Québec. La plaque de tuff ornée d’une croix 1 , surmontée de motifs végétaux et géométriques est installée sur le manteau de sa cheminée, dans le sous-sol aménagé de sa maison. Elle ...

  12. Le CERN et les Institutions

    CERN Document Server

    Barbalat, Oscar

    1996-01-01

    Une première partie de l'exposéŽ sera consacrée àˆ une brève description des principaux organes de l'Union EuropéŽennne: Conseil, Parlement et Commission ainsi que la structure de la Commission. On passera ensuite en revue le Programme-Cadre de Recherche et DéŽveloppement Technologique et les principaux programmes spéŽcifiques auxquels participe le CERN (ESPRIT, ACTS, TMR) On situera ensuite les autres organisations et initiatives scientifiques européŽennes (ESA, ESO, ESRF, JET, ISTC, EUREKA, ...) pour terminer par une brève revue des relations entre le CERN avec ces difféŽrentes institutions en déŽveloppant plus particulièrement celles avec la Commission.

  13. Publications | Page 164 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    African Urban Harvest : Agriculture in the Cities of Cameroon, Kenya and Uganda ... le temple et le marché : Réflexions à la croisée de la science, de la religion et ... Modern and Traditional Irrigation Technologies in the Eastern Mediterranean.

  14. La geografia come monumento. Il progetto di Auguste Perret per Le Havre / Geography as a monument. The Auguste Perret’s project for Le Havre

    Directory of Open Access Journals (Sweden)

    Antonio Nitti

    2014-11-01

    Full Text Available Nel progetto di Auguste Perret per Le Havre una forma chiaramente compatta ed evocativa dell’urbanità della città storica si definisce a partire dalle relazioni stabilite con quegli elementi della geografia fisica che costituiscono l’identità del luogo nel quale questa si colloca, e costruisce una significativa relazione con gli spazi aperti e vasti della natura, acquisendo in questo modo quella ‘dimensione’ e quei caratteri propri della città contemporanea. Nei suoi spazi collettivi, che rimandano a una cultura dell’abitare che affonda le proprie radici nella più generale storia della città francese, Le Havre rappresenta sé stessa e traduce nella Place de l’Hôtel de Ville le ripide pendici della falesia, nella Porte Océane l’orizzonte lontano dell’Oceano, nel Front-de-mer Sud l’altra riva della foce della Senna, e fa di questi i veri ‘monumenti’ della città. / In the Auguste Perret’s project for Le Havre a clearly compact form, evocative of urbanity of the historical city, is defined starting from the relations established with those elements of physical geography which constitute the identity of the place where the city is located, and builds a significant relationship with the open and vast spaces of nature, thus acquiring the ‘size’ and those features of the contemporary city. In its public spaces, which refer to a culture of inhabiting that is rooted in the more general history of the French city, Le Havre represents itself and translates in the Place de l'Hôtel de Ville, the steep slopes of the cliff, in the Porte Oceane the distant horizon of the ocean, in the Front-de-mer South the other bank of the mouth of the Seine, and defines these as the real 'monuments' of the city.

  15. Aratos et le stoïcisme Aratus and Stoicism Arato e lo stoicismo

    Directory of Open Access Journals (Sweden)

    Christophe Cusset

    2011-07-01

    Full Text Available Dans cet article nous envisageons d'abord les points de rencontre possibles entre Aratos et le stoïcisme du point de vue de la biographie du poète avant de reprendre la lecture de l'ouverture des Phénomènes à la lumière de l'Hymne à Zeus de Cléanthe. Les rapports d’Aratos avec le stoïcisme se révèlent finalement être assez minces en ce qui concerne l’écriture du poète. Aratos est surtout stoïcien par l’intérêt que les Stoïciens ont porté à son œuvre qui se trouve avoir été composée dans un milieu assez fortement marqué par la philosophie du Portique.In this paper I consider first the possible points of tangent between Aratus and Stoicism as far as the biographical point of view is concerned, and secondly read the opening of the Phaenomena in the light of the Hymn to Zeus of Cleanthes again. Aratus’ links with Stoicism ultimately prove to be quite thin in the writing of the poet. Stoic Aratus is especially the creation of the interest that Stoics did manifest to his work, a work which was composed in an environment quite widely influenced by the philosophy of the Stoa.In questo articolo sono considerati in primo luogo i possibili punti di contatto tra Arato e lo stoicismo dal punto di vista della biografia del poeta prima di riprendere la lettura dell’inizio dei Fenomeni alla luce dell’Inno a Zeus di Cleante. I rapporti tra Arato e lo stoicismo si rivelano alquanto esili in ciò che concerne la scrittura del poeta. Arato è stoico principalmente per l’interesse che gli stoici hanno mostrato nei confronti della sua opera, che è stata composta in un milieu profondamente segnato dalla filosofia della Stoa.

  16. CEA to peritoneal carcinomatosis index (PCI) ratio is prognostic in patients with colorectal cancer peritoneal carcinomatosis undergoing cytoreduction surgery and intraperitoneal chemotherapy: A retrospective cohort study.

    Science.gov (United States)

    Kozman, Mathew A; Fisher, Oliver M; Rebolledo, Bree-Anne J; Parikh, Roneil; Valle, Sarah J; Arrowaili, Arief; Alzahrani, Nayef; Liauw, Winston; Morris, David L

    2018-03-01

    Serum tumor markers are prognostic in patients with colorectal cancer peritoneal carcinomatosis (CRPC) undergoing cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC). Assessment of the ratio of tumor marker to volume, as depicted by peritoneal carcinomatosis index (PCI), and how this may affect overall (OS) and recurrence free survival (RFS) has not been reported. Survival effect of this ratio was analyzed in patients with CRPC managed from 1996 to 2016 with CRS and IPC. Of 260 patients included, those with low CEA/PCI ratio (PCI ratio was most pronounced in patients with PCI ≤ 10 (OS of 72 vs 30 months, P PCI ratio was independently associated with poorer OS (adjusted HR 1.85, 95%CI 1.11-3.10, P = 0.02) and RFS (adjusted HR 1.58, 95%CI 1.04-2.41, P = 0.03). CEA/PCI ratio is an independent prognostic factor for OS and RFS in CRPC. This novel approach allows both tumor activity and volume to be accounted for in one index, thus potentially providing a more accurate indication of tumor biological behavior. © 2017 Wiley Periodicals, Inc.

  17. Medical therapy v. PCI in stable coronary artery disease: a cost-effectiveness analysis.

    Science.gov (United States)

    Wijeysundera, Harindra C; Tomlinson, George; Ko, Dennis T; Dzavik, Vladimir; Krahn, Murray D

    2013-10-01

    Percutaneous coronary intervention (PCI) with either drug-eluting stents (DES) or bare metal stents (BMS) reduces angina and repeat procedures compared with optimal medical therapy alone. It remains unclear if these benefits are sufficient to offset their increased costs and small increase in adverse events. Cost utility analysis of initial medical therapy v. PCI with either BMS or DES. . Markov cohort decision model. Data Sources. Propensity-matched observational data from Ontario, Canada, for baseline event rates. Effectiveness and utility data obtained from the published literature, with costs from the Ontario Case Costing Initiative. Patients with stable coronary artery disease, confirmed after angiography, stratified by risk of restenosis based on diabetic status, lesion size, and lesion length. Time Horizon. Lifetime. Perspective. Ontario Ministry of Health and Long Term Care. Interventions. Optimal medical therapy, PCI with BMS or DES. Lifetime costs, quality-adjusted life years (QALYs), and the incremental cost-effectiveness ratio (ICER). of Base Case Analysis. In the overall population, medical therapy had the lowest lifetime costs at $22,952 v. $25,081 and $25,536 for BMS and DES, respectively. Medical therapy had a quality-adjusted life expectancy of 10.1 v. 10.26 QALYs for BMS, producing an ICER of $13,271/QALY. The DES strategy had a quality-adjusted life expectancy of only 10.20 QALYs and was dominated by the BMS strategy. This ranking was consistent in all groups stratified by restenosis risk, except diabetic patients with long lesions in small arteries, in whom DES was cost-effective compared with medical therapy (ICER of $18,826/QALY). Limitations. There is the possibility of residual unobserved confounding. In patients with stable coronary artery disease, an initial BMS strategy is cost-effective.

  18. Vivre avec ou par le risque à l’île de Sein ?

    Directory of Open Access Journals (Sweden)

    Annaig Oiry

    2012-02-01

    Full Text Available L’île de Sein, située au large des côtes finistériennes, fait figure de « territoire du risque » par excellence : cette île basse est confrontée à de fréquentes et violentes tempêtes, la population vit « avec le risque » de submersion depuis des générations tout en voyant la probabilité des aléas catastrophiques augmenter en raison de la carence en aménagement et des conséquences probables du réchauffement climatique. L’image du risque, notamment les photographies de tempête, sert de support à la diffusion d’un sentiment anxiogène justifiant des actions de gestion du risque, mais entretient aussi un sentiment de fascination à l’égard des épisodes tempétueux. Cependant, les îliens portent un regard bien plus critique sur le spectaculaire véhiculé par de telles représentations. Le présent article se penche sur ces rapports entre représentations sociales du risque et iconographie du risque.This article stresses on relationships between hazard’s social representations and iconographies. As an illustration, Sein Island (located near by the Brittany coast, in Finistère. This island is considered as a symbol of natural hazard territory: indeed this low island has been confronted for decades to face significant flood hazard that is nowadays strengthened by the consequences of global warming and a lack of infrastructures. Pictures of flood hazards, and more particularly pictures of storms, are used in order to spread around the fear of natural disasters. This fear justifies the management policies implemented on the island. However islanders criticize pictures which are too spectacular and too distorted. Those gaps between hazard’s representations and iconographies are the main subjects of this article.

  19. Agir sur le gaspillage alimentaire

    OpenAIRE

    Jan, Sophie; Baron, Florence

    2016-01-01

    On estime aujourd'hui à 25% les pertes d'aliments post-récolte et en aval, en raison de leur altération par des microorganismes. L'étude menée ici illustre le risque d'altération engendré par une rupture dans la chaîne du froid, en prenant comme modèle un aliment liquide pasteurisé et réfrigéré, riche en nutriments et dont la température ne doit pas dépasser 4°C.

  20. Il difficile rapporto tra cultura e mercato in Italia. Note a margine della ricerca "Le attività culturali e lo sviluppo economico: un esame a livello territoriale" / The difficult relationship between culture and market in Italy. Notes on the research “Le attività culturali e lo sviluppo economico: un esame a livello territoriale” (Non industrial cultural activities and economic growth: a territorial study

    Directory of Open Access Journals (Sweden)

    Ginevra Domenichini

    2013-01-01

    Full Text Available Il contributo presenta gli esiti della ricerca condotta da Enrico Beretta e Andrea Migliardi sulle interdipendenze tra il settore culturale italiano e il sistema produttivo del Paese; oggetto di analisi sono, in particolare, le attività culturali a contenuto non industriale – arti visive, spettacolo dal vivo, patrimonio artistico-culturale. Partendo dal presupposto che tali risorse possono in vari modi concorrere allo sviluppo, gli Autori propongono una analisi delle dimensioni e caratteristiche del settore da un punto di vista economico e gestionale-amministrativo. Le considerazioni avanzate in merito allo sfruttamento di tale risorsa e gli interventi di policy proposti per una sua corretta valorizzazione offrono un significativo contributo sotto il profilo teorico-conoscitivo e applicativo al dibattito, estremamente attuale, sul valore e le potenzialità di sviluppo, anche economico, del settore.   The paper presents the output of the research conducted by Enrico Beretta and Andrea Migliardi on the connections between the Italian cultural sector and the Country’s economy; the study focuses, in particular, on non industrial cultural activities which include the visual and performing arts and the heritage. Acknowledging their contribution to development, the Authors analyse the dimensions and characteristics of the sector both from an economic and administrative/managerial perspective. Their remarks on the current level of exploitation of such resource and the suggested policy recommendations for its enhancement represent a valuable contribution to the current debate on the value and development potentials of the sector.

  1. CMS Tracker Readout Prototype Front-End Driver PCI Mezzanine Card (Mk1) (connector side)

    CERN Multimedia

    J.Coughlan

    1998-01-01

    The tracking system of the CMS detector at the LHC employs Front End Driver (FED) cards to digitise, buffer and sparsify analogue data arriving via optical links from on detector pipeline chips. This paper describes a prototype version of the FED based upon the popular commercial PCI bus Mezzanine Card (PMC) form factor. The FED-PMC consists of an 8 channel, 9 bit ADC, card, providing a 1 MByte data buffer and operating at the LHC design frequency of 40 MHz. The core of the card is a re-programmable FPGA which allows the functionality of the card to be conveniently modified. The card is supplied with a comprehensive library of C routines.The PMC form factor allows the card to be plugged onto a wide variety of processor carrier boards and even directly into PCI based PCs. The flexibility of the FPGA based design permits the card to be used in a variety of ADC based applications.

  2. Prends soin du métro. Le contrôle-soin, forme émergente des régulations et menaces souterraines

    Directory of Open Access Journals (Sweden)

    Yves Jouffe

    2015-05-01

    Full Text Available Le métro de Santiago a subi une dégradation significative de ses conditions de transport du fait de son intégration au Transantiago, le réseau de bus urbains. L’opérateur du métro a donné beaucoup de visibilité à ses dispositifs de contrôle des nouvelles masses d’usagers : barrières optimisées, signalétique omniprésente, agents démultipliés, etc. L’étude du discours officiel de l’entreprise et surtout l’observation ethnographique de ces dispositifs révèlent que les modalités de contrôle ont elles-mêmes évoluées. En plus de la menace légale exercée contre les étrangers et de la régulation des flux par une discipline des corps, un contrôle-soin s’exerce sur une population à protéger : la population qui bénéficie du soin de l’opérateur lui est redevable d’un contre-soin. Le contrôle-soin constitue non seulement une modalité émergente de contrôle mais aussi la forme générale du contrôle dans le métro de Santiago.

  3. Publications | Page 163 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En Afrique cependant, plus particulièrement pour les femmes vivant en milieu rural, l'accès à l'information est limité. Les nouvelles technologies de l'information et des... Le laboratoire, le temple et le marché : Réflexions à la croisée de la science, de la religion et du développement. Il s'agit là d'un ouvrage fascinant et très ...

  4. TUKAN—An 8K Pulse Height Analyzer and Multi-Channel Scaler With a PCI or a USB Interface

    Science.gov (United States)

    Guzik, Z.; Borsuk, S.; Traczyk, K.; Plominski, M.

    2006-02-01

    In this paper we present two types of 8K-channel analyzers designed for spectroscopy and intensity versus time measurements. The first type (Tukan-8K-PCI) incorporates a PCI interface and is designed to be plugged into a PCI slot of a normal PC. The second type (Tukan-8K-USB) incorporates a USB interface. It is mounted in a separate screened box and can be powered either directly from the USB port or from an external dc source (wall adapter or battery). Each type of device may operate in either of two independent operational modes: Multi Channel Analysis (MCA) and Multi-Channel Scaling (MCS). The most crucial component for the MCA mode-the Peak Detect and Hold circuit-is featuring a novel architecture based on a diamond transistor. Its analog stage can accept analog pulses with rise times as short as 100 ns and has a differential linearity below 1% with sliding scale averaging over the full scale. The functionality includes automatic stop on a programmable count in the Region-Of-Interest (ROI) and on preset live- or real time. The MCS mode works at medium counting rates of up to 8 MHz. The dwell time, the number of channels and single or multi-sweep mode may be preset. Each of these parameters can also be controlled externally via four user configurable logical I/O lines. A single Altera FLEX 10KE30 FPGA provides all control functions and incorporates PCI interface. The USB interface is based on FTDI FIFO controller. Advanced and user-friendly software has been developed for the analyzer

  5. Assessment of Al-Amarah street within the Al-kut city using pavement condition index (PCI and GIS technique

    Directory of Open Access Journals (Sweden)

    Al-Neami Mohammed

    2018-01-01

    Full Text Available The capabilities of geographical system and their spatial analysis is considered the most appropriate tools to enhance pavement management operations, with features such as graphical display of pavement condition. In Iraq, most of transportation agencies do not have a tool that is used as a database for road deteriorations, so there is a need for road surveying and storing the collected information in GIS to know the condition of every road with details. Furthermore, these data can be used for maintenance process and estimation of prior cost. This research has been carried out to estimate of flexible pavement condition through visual surveys using the Pavement Condition Index (PCI method; so it can provide an easy way to calculate the PCI based on GIS data with Micro PAVER software 5.2. Al-Amarah Street, which is internal road in Al-Kut city in the eastern part of Iraq, is used as a case study. The average pavement condition index of the selected case study is found to be “64” using Micro PAVER 5.2 software which mean “Fair” pavement condition. Arc Map 9.3 has been applied in this study to make an integrated maintenance system for each road in the region demonstrating the annual road deteriorations and the resulting change in the PCI values which occurs every year. The study provides an easy and simplified way of presentation the details of deteriorations on the satellite or the geographical map of the road in which each type of distress has been symbolized with specific sign and each PCI value has been represented with specific color.

  6. Emozione e somatizzazione

    Directory of Open Access Journals (Sweden)

    Sabine Parmentelot

    2004-09-01

    Full Text Available Consacreremo la prima parte di quest'articolo alle manifestazioni corporee dell'emozione. La psicologia sperimentale, insieme alla neuro-biologia, hanno evidenziato le differenti risposte corporee più o meno percettibili. Ma al di là di queste manifestazioni puramente oggettive le cui percentuali e oscillazioni possono essere valutate, misurate ... E' l'aspetto soggettivo e le loro ripercussioni che c'interessa. Quali significati possono avere le emozioni per la persona che le prova? Questi temi saranno l'oggetto della seconda parte. Ci situiamo in quanto ricercatori che interrogano altri soggetti, ma è evidente che non possiamo fare astrazione delle nostre passioni.

  7. Le vespe qualunquiste e la satira politica

    Directory of Open Access Journals (Sweden)

    Maurizio Cocco

    2012-10-01

    Full Text Available The weekly review «L’Uomo Qualunque» was the most popular newspaper in Italy in the second postwar. Created by a Neapolitan playwright, Guglielmo Giannini, it was the voice of the discontent of the middle classes and strongly opposed the CLN governments and the antifascist political parties.The paper aims to provide analysis of the use of satire in the newspaper. It focuses on the section named «Le vespe», in which Giannini used jokes and humorous anecdotes to criticize the transition from fascism to democracy; in particular the epuration, the political system and its personnel.

  8. Le devenir Afrique de Lumumba, Nkrumah et Sankara. Ou de l’importance de ressasser le passé contre le discours de Dakar

    Directory of Open Access Journals (Sweden)

    Rampazzo Bazzan Marco

    2012-01-01

    Full Text Available Cet article, issu d’une étude menée au sein du Groupe de Recherches Matérialistes, vise à critiquer la matrice idéologique neocolonialiste du célèbre et controversé discours que Nicolas Sarkozy tint à Dakar en 2007. Les thèses de l’ancien Président de la République Française sont d’emblée reconduites aux stéréotypes colonialistes, puis déconstruites à partir de l’invitation à revenir sur cette page de l’histoire formulée par Makhili Gassama, ancien conseilleur de Senghor. Tout en reconnaissant la complicité d’une grosse partie des politiciens africains dans le partage et saccage de leur continent et dans les guerres qui les traversent, l’article veut contrecarrer le discours de Sarkozy par les paroles de trois représentants les plus significatifs du panafricanisme: Kwame Nkrumah, Patrice Lumumba et Thomas Sankara. Ces trois hommes politiques ont dénoncé avec fermeté les intérêts économiques néocoloniaux qui empêchent une véritable indépendance de l’Afrique. Il s’agit en outre de souligner que l’oblitération et le refoulement des souffrances provoquées par la colonisation au sein des pays de l’occident sont l’indice de l’acceptation par la majorité de leurs populations de l’état des choses en Afrique, qui est ainsi, en quelque sorte, naturalisé. Cette acceptation tacite constitue une condition fondamentale de la reproduction quotidienne du dispositif pacificateur de domination au sein du monde développé. Les maux de l’Afrique trouvent leur cause alors moins dans une attitude de l’homme africain que dans un système de domination économique et idéologique assuré par les institutions internationales tels que l’ONU, la Banque mondiale ou le FMI.

  9. Hostelería para fines específicos en el aula de E/LE

    OpenAIRE

    Giménez Folqués, David

    2011-01-01

    Cuando un alumno extranjero se dispone a estudiar un nuevo idioma, tiene la esperanza de volver a su país sabiendo al menos desenvolverse en los ámbitos más esenciales: en una conversación cotidiana, en el banco, en una entrevista de trabajo o,por qué no, en un restaurante. Así pues, hemos seleccionado la Hostelería para fines específicos en el aula de E/LE como proyecto con el fin de auxiliar al alumno en este campo. Este objetivo lo llevamos a cabo mediante un enfoque por tareas, es decir,a...

  10. Os Paradigmas e princípios científicos da ciência da informação propostos por Le-Coadic: aplicação no uso da informaçãoThe paradigms and scientific principles of information science proposed by Le-Coadic: application in the use of information

    Directory of Open Access Journals (Sweden)

    Giovana Deliberali Maimone

    2008-08-01

    Full Text Available Os Paradigmas e princípios científicos da ciência da informação propostos por Le-Coadic: aplicação no uso da informaçãoThe paradigms and scientific principles of information science proposed by Le-Coadic: application in the use of information Apresenta os paradigmas e princípios científicos da Ciência da Informação relatados pelos estudos de Le Coadic, enfocando as relações desses com o uso da informação. Destaca-se ainda as linguagens documentárias como um importante recurso para a recuperação e uso da informação. Abstract It presents the paradigms and scientific principles of Information Science reported by Le Coadic studies, focusing on its relations with the information’s use. It also stress the documentary languages as an important resource for information retrieval and use.

  11. Apprendre ensemble en classe via des jeux vidéo populaires : le modèle du LAN pédagogique

    Directory of Open Access Journals (Sweden)

    Samuelle Ducrocq-Henry

    2011-05-01

    Full Text Available La thèse intitulée « Les tribus ludiques» expose le modèle du LAN pédagogique (LP découlant d’une étude des compétitions de jeu vidéo en réseau local (LAN parties. Incarnant un rite de passage quasi tribal chez les 12-25 ans, les LAN semblent favoriser socialisation et apprentissage. Un LP permet aux enseignants d’initier des expériences réseautiques similaires et formatrices en classe, tenues simultanément dans les mondes réels et virtuels, en détournant le scénario de jeux vidéo multijoueurs populaires, pour en faire des simulateurs propices à l’enseignement de disciplines diverses. Sa procédure simple et abordable révèle le potentiel du Serious Gaming en éducation.

  12. Lo Sport e le sue storie: l'esperienza aquilana, quando lo sport supera l'emergenza

    Directory of Open Access Journals (Sweden)

    Marco Pasini

    2013-04-01

    Full Text Available Tale progetto di ricerca, della durata di 12 mesi (da luglio 2010 a luglio 2011 e commissionato dal Ministero del Lavoro e delle Politiche Sociali , intende ricostruire il tessuto sociale di 400 giovani delle scuole secondarie di I e II livello de L’Aquila e provincia attraverso lo sport. Tessuto sociale leso e sfaldato in seguito all’evento sismico che il 6 aprile 2009 colpì il capoluogo abruzzese, in cui oltre all’improvvisa e immediata perdita di tutti i beni materiali sono venuti meno anche i canali di socializzazione primari e secondari. Una quotidianità da ricostruire anche e soprattutto attraverso il concetto di attività sportiva volta, in questo caso più che mai, alla realizzazione di cittadinanza, partecipazione, formazione umana, integrazione e coesione sociale. Con particolare attenzione agli sport di squadra che permettono uno sviluppo affettivo, cognitivo, relazionale e una maggiore comprensione/costruzione della propria personalità. Dunque lo sport come strumento principe per l’inclusione sociale, in quanto gioco che esalta l’armonia e le dinamiche di cooperazione. Lo sport, in generale, va considerato un fatto sociale; è un fenomeno sociale, un sistema culturale - che agisce tra comunicazione, economia e politica - e si presenta come una costruzione sociale. Costruzione generata da significati e rappresentazioni collettive.

  13. Sur le discours et l’histoire en foucault. Entretien avec Jacques Guilhaumou

    Directory of Open Access Journals (Sweden)

    Welisson Marques

    2013-08-01

    Full Text Available Dans cet entretien inédit, Jaques Guilhaumou parle sur la question du discours et de l´histoire dans la pensée de Michel Foucault en regardant telles questions à partir du belvédère de l’Analyse du Discours selon la perception française. Il commence en présentant un panorama de ses travaux plus actuels et souligne ensuite lele décisif de Foucault dans le établissement de une nouvelle relation entre le discours et l´histoire. Dans cette direction, il donne des détails sur quelques influences épistémologiques de la pensée foucaultienne qui viennent surtout de Nietzsche et Koselleck. Comme un grand étudiant de la pensée marxiste, Guilhaumou parle aussi sur le concept de l´ideologie et ses plusières métamorphoses conceptuelles dans autres champs jusqu´au moment de parler sur la question du pouvoir. Il parle quand même sur la problématique de l´analyse des images dans l´Analyse du Discours, une question favorable pour beaucoup des analystes du discours qui s´occupent avec le syncrétisme sémiotique des ses objets dans l´actualité. Enfin, il indique l´existence de une théorie du discours diluée dans la pensée du philosophe.

  14. Politique CERN pour le contrôle d'accès à son domaine et description de l'implantation en cours

    CERN Document Server

    Jacot, C

    1998-01-01

    Une volonté politique claire émanant de la direction du CERN et de l'Access Control Panel a chargé la section ST/MC/AC de mettre en place un concept de contrôle d'accès global et cohérent pour l'ensemble des accès au domaine et aux sites de ses accélérateurs. Cela implique que depuis l'accueil et l'enregistrement des personnes jusqu'à la gestion, la surveillance du domaine ainsi que les installations techniques de contrôle d'accès, tous ces services qui sont complémentaires sont désormais rassemblés dans une seule section. Un projet de management des autorisations fortement informatisé ainsi que la productions des cartes CERN sont en cours d'installation. De nombreuses autres installations de contrôle d'accès sont opérationnelles et d'autres sont en cours de réalisation. Toutes seront ensuite intégrées et supervisées depuis une centrale située dans le bâtiment 120, cette dernière est exploitée par une société de surveillance au bénéfice d'un contrat avec le CERN.

  15. Viollet-le-Duc ou la caricature au cour du style

    OpenAIRE

    Linford, Sarah

    2014-01-01

    « Il y a le style ; il y a les styles. » Ainsi commence l’un des articles phares du Dictionnaire raisonné de l’architecture française du XIe au XVIe siècle, d’Eugène-Emmanuel Viollet-le-Duc. L’article sur le style paraît dans le huitième tome, en 1868, quatorze ans après la publication du premier. Article de maturité, il constitue un condensé de la pensée de Viollet-le-Duc et révèle certaines clefs de voûte de son système. « Les styles sont les caractères qui font distinguer entre elles les é...

  16. La culture matérielle enfantine entre le cute et le cool

    Directory of Open Access Journals (Sweden)

    Gilles Brougère

    2012-11-01

    Full Text Available Cet article explore la façon dont on adresse un objet à l’enfant, c’est-à-dire la rhétorique à l’œuvre pour séduire les enfants (et les parents dans certains cas. Si l’éducation peut être présente pour certains produits, domine très largement aujourd’hui une rhétorique du fun, une association de l’objet à l’enfance via le divertissement et l’insertion dans une culture des pairs. Pour partie cet adressage se fait à travers l’utilisation de personnages ou d’univers sous licence qui proposent une rhétorique du fun prête à l’emploi. Mais l’analyse des univers disponibles montre que l’on peut décomposer le fun à travers deux pôles opposés, le cute, dont Hello Kitty constitue un exemple archétypal, et le cool, que Titeuf permet de saisir dans sa logique. A travers la distinction du cute et du cool, il s’agit de contribuer à l’analyse du déploiement contemporain d’une culture du divertissement qui est incorporée aux objets de l’enfance, tout en étant un moyen de capter l’intérêt de ceux-ci.

  17. Le pompage optique naturel dans le milieu astrophysique

    Science.gov (United States)

    Pecker, J.-C.

    The title of this lecture abstracts only a part of it : the importance in astrophysics of the study of non-LTE situations has become considerable, as well in the stellar atmospheres as, still more, in the study of fortuitous coincidences as a mechanism of formation of emission line nebular spectra, or of molecular interstellar « masers ». Another part of this talk underlines the role of Kastler in his time, and describes his warm personality through his public reactions in front of the nuclear armement, of the Viet-Nam and Algerian wars, of the problems of political refugees... Kastler was a great scientist ; he was also a courageous humanist. 1976 : Les accords nucléaires du Brésil : allocution d'ouverture (19 mars). Colloque sur le sujet ci-dessus. 1976 : La promotion de la culture dans le nouvel ordre économique international, allocution à l'occasion d'une table ronde sur ce thème par l'UNESCO (23-27 juin 1976) ; « Sciences et Techniques », octobre 1976. 1979 : La bête immonde (avec J.-C. Pecker), « Le Matin », 20 mars. 1979 : Appel à nos ministres (avec J.-C. Pecker), « Le Monde », 13 décembre. 1979 : Le flou, le ténébreux, l'irrationnel (avec J.-C. Pecker), « Le Monde », 14 septembre. 1980 : Education à la paix, Préface, in : Publ. UNESCO. 1981 : Le vrai danger, « Le Monde », 6 août 1981. 1982 : Nucléaire civil et militaire, « Le Monde », 1er juin 1982. 1982 : Les scientifiques face à la perspective d'holocauste nucléaire (texte inédit). Le titre de cette communication en résume seulement une partie : l'importance prise en astrophysique par l'analyse des situations hors ETL est devenue considérable, qu'il s'agisse des atmosphères stellaires, ou plus encore, des coïncidences fortuites de la formation des spectres d'émission nébulaires, ou des « masers » moléculaires interstellaires. Une autre partie de cet exposé souligne lele de Kastler dans son époque, et décrit sa personnalité généreuse à travers ses r

  18. Jeu et fiction dans un jeu de cartes à collectionner : le cas de Magic : l’Assemblée

    Directory of Open Access Journals (Sweden)

    Pierre Cuvelier

    2011-06-01

    Full Text Available Le genre du jeu de cartes à collectionner apparaît en 1993 avec Magic : l’Assemblée de Richard Garfield. Si la plupart des émules de Magic sont des jeux dérivés d’univers de licence comme Pokémon, Magic se fondait sur un univers de fantasy inédit, enrichi par des extensions successives, et dont les cartes restent le principal vecteur. Je me propose ici de réfléchir sur les rapports qui se nouent entre le jeu et la fiction dans Magic, et d’examiner les contraintes, le fonctionnement et les principaux procédés fictionnels propres à ce support singulier. Magic fait partie des jeux à composante fictionnelle forte, dont les règles comportent un caractère mimétique certain, bien que limité. Les différents éléments d’une même carte et les cartes entre elles fonctionnent comme des fragments qui se combinent pour pointer vers une réalité fictive qui, bien que conçue par l’éditeur sur le modèle des univers de licence à forte cohérence (notamment les récentes fictions transmédiatiques, laisse à rêver aux joueurs par les blancs et les ambiguïtés inhérentes à cette articulation entre jeu et fiction. Les tâtonnements de l’éditeur au fil des extensions sont riches d’enseignements sur les possibilités et les limites d’un tel support, où la fiction narrative linéaire doit laisser place, à petite échelle, à une fiction plus structurelle, prenant la forme d’environnements mis en tension plutôt que de narrations linéaires.

  19. Lele de la sphère publique en réseau pour ce qui est de favoriser ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Una Hakika : Porter à grande échelle les solutions numériques pour la gestion des conflits au Kenya et en Birmanie. L'information erronée, qu'elle soit le fruit de rumeurs ou d'une désinformation intentionnelle, peut alimenter le conflit et exercer de profondes répercussions sur la paix, la... Voir davantageUna Hakika : Porter ...

  20. Big Bang pour le grand public - French version only

    CERN Multimedia

    2004-01-01

    Pour commémorer les 50 ans du CERN et l'année de la physique en 2005, la section de physique de l'Université de Genève ouvre une fois de plus ses portes aux non initiés et organise une série de conférences de vulgarisation scientifique. La première conférence, le 7 décembre prochain aura pour thème le Big-Bang et les observations qui corroborent cette théorie. Le Professeur Georges Meylan, Directeur du Laboratoire d'Astrophysique de l'EPFL, donnera cette conférence destinée à tous les publics. Chacune des conférences débutera par une démonstration de détection de rayons cosmiques dans l'auditoire et l'utilisation de ces signaux venus du fond de l'univers pour créer une ?musique cosmique', en collaboration avec le Professeur Ellberger et Nikolai Mihailov du conservatoire de musique de Genève. Ces processus cosmiques étant aléatoires, chacun de ces concerts sera unique. Les preuves observationnelles du Big Bang par le Professeur Georges Meylan Directeur du Laboratoire d'Astrophysique ...