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Sample records for bk070031 idm symphony

  1. Seismic Symphonies

    Science.gov (United States)

    Strinna, Elisa; Ferrari, Graziano

    2015-04-01

    The project started in 2008 as a sound installation, a collaboration between an artist, a barrel organ builder and a seismologist. The work differs from other attempts of sound transposition of seismic records. In this case seismic frequencies are not converted automatically into the "sound of the earthquake." However, it has been studied a musical translation system that, based on the organ tonal scale, generates a totally unexpected sequence of sounds which is intended to evoke the emotions aroused by the earthquake. The symphonies proposed in the project have somewhat peculiar origins: they in fact come to life from the translation of graphic tracks into a sound track. The graphic tracks in question are made up by copies of seismograms recorded during some earthquakes that have taken place around the world. Seismograms are translated into music by a sculpture-instrument, half a seismograph and half a barrel organ. The organ plays through holes practiced on paper. Adapting the documents to the instrument score, holes have been drilled on the waves' peaks. The organ covers about three tonal scales, starting from heavy and deep sounds it reaches up to high and jarring notes. The translation of the seismic records is based on a criterion that does match the highest sounds to larger amplitudes with lower ones to minors. Translating the seismogram in the organ score, the larger the amplitude of recorded waves, the more the seismogram covers the full tonal scale played by the barrel organ and the notes arouse an intense emotional response in the listener. Elisa Strinna's Seismic Symphonies installation becomes an unprecedented tool for emotional involvement, through which can be revived the memory of the greatest disasters of over a century of seismic history of the Earth. A bridge between art and science. Seismic Symphonies is also a symbolic inversion: the instrument of the organ is most commonly used in churches, and its sounds are derived from the heavens and

  2. IDM and not only

    Science.gov (United States)

    Ilnicka, A.; Krawczyk, M.; Robens, T.; Sokolowska, D.

    In this note, we discuss recent updates to a previous scan for the Inert Doublet Model, a two Higgs doublet model with a dark matter candidate. We explicitly show the inclusion of updated constraints on direct detection reduces the allowed parameter space significantly. We furthermore discuss the IDMS - an extension of the IDM with a complex singlet.

  3. Interactive database management (IDM).

    Science.gov (United States)

    Othman, R

    1995-08-01

    Interactive database management (IDM) is a data editing software that provides complete data editing at the time of initial data entry when information is 'fresh at hand'. Under the new interactive system, initial data recording is subjected to instant data editing by the interactive computer software logic. Data are immediately entered in final form to the database and are available for analysis. IDM continuously checks all variables for acceptability, completeness, and consistency. IDM does not allow form duplication. Many functions including backups have been automated. The interactive system can export the database to other systems. The software has been implemented for two Department of Veterans Affairs Cooperative Studies (CCSHS #5 and CSP #385) which collect data for 1400 and 1000 variables, respectively at 28 VA medical centers. IDM is extremely user friendly and simple to operate. Researchers with no computer background can be trained quickly and easily to use the system. IDM is deployed on notebook microcomputers making it portable for use anywhere in the hospital setting.

  4. Strauss, R.: Symphony in F minor, Op. 12... Tokyo Metropolitan Symphony Orchestra / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "Strauss, R.: Symphony in F minor, Op. 12... Tokyo Metropolitan Symphony Orchestra / Hiroshi Wakasugi. Denon CD CO-75 860 (54 minutes); Symphony - comparative version: SNO, Järvi" (8/93)(CHAN) CHAN 9166

  5. Gade: Symphonies. Copenhagen Collegium Musicum / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1994-01-01

    Uuest heliplaadist "Gade: Symphonies. Copenhagen Collegium Musicum. Michael Schonwandt.Marco Polo Dacapo CD DCCD 9201/2; Comparative versions: Symphony No. 1. Stockholm Sinf. / Järvi (11/87) BIS CD 339; Symphony No. 2.Stockholm Sinf. / Järvi (12/87) BIS CD 355; Symphony No. 4. Stockholm Sinf. / Järvi" (7/87) BIS CD 338; Symphony No. 6. Stockholm Sinf. / Järvi (12/87) BIS CD 356

  6. (Integrated Diffractive Mirrors (IDM) Ion Traps)

    Science.gov (United States)

    2014-03-04

    and three packaged and tested, we expect testing and application of these optics to continue well beyond the completion of the IDM program. (a) Papers...PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: ...... ...... 1-1 IDM Final Report December 31, 2013 Georgia Tech Research Institute Griffith...and application of these optics to continue well beyond the completion of the IDM program. 1-3 Table of Contents Abstract

  7. Rimsky-Korsakov: Symphonies / Robert Cowan

    Index Scriptorium Estoniae

    Cowan, Robert

    1994-01-01

    Uuest heliplaadist "Rimsky-Korsakov: Symphonies No. 1, Op. 1; No. 2 "Antar", Op. 9. Russian State Symphony Orchestra, Evgeni Svetlanov. RCA Victor Red Seal CD 09026 62558-2; Selected comparisons: Symphony No. 1. Gothenburg SO, Järvi (2/89) (DG) 423 604-2GH2; Symphony No. 2. Gothenburg SO, Järvi (2/89) (DG) 423 604-2GH2

  8. Experiencing Earth's inaudible symphony

    Science.gov (United States)

    Marlton, Graeme; Charlton-Perez, Andrew; Harrison, Giles; Robson, Juliet

    2017-04-01

    Everyday the human body is exposed to thousands of different sounds; smartphones, music, cars and overhead aircraft to name a few. There are some sounds however which we cannot hear as they are below our range of hearing, sound at this level is known as infrasound and is of very low frequency. Such examples of infrasound are the sounds made by glaciers and volcanos, distant mining activities and the sound of the ocean. These sounds are emitted by these sources constantly all over the world and are recorded at infrasound stations, thus providing a recording of Earth's inaudible symphony. The aim of this collaboration between artists and scientists is to create a proof of concept immersive experience in which members of the public are invited to experience and understand infrasound. Participants will sit in an installation and be shown images of natural infrasound sources whilst their seat is vibrated at with an amplitude modulated version of the original infrasound wave. To further enhance the experience, subwoofers will play the same amplitude modulated soundwave to place the feeling of the infrasound wave passing through the installation. Amplitude modulation is performed so that a vibration is played at a frequency that can be felt by the human body but its amplitude varies at the frequency of the infrasound wave. The aim of the project is to see how humans perceive sounds that can't be heard and many did not know were there. The second part of the project is educational in which that this installation can be used to educate the general public about infrasound and its scientific uses. A simple demonstration for this session could be the playing of amplitude modulated infrasound wave that can be heard as opposed to felt as the transport of an installation at this is not possible and the associated imagery.

  9. Raid, Kaljo: Symphony No. 2, "Stockholm" / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1996-01-01

    Uuest heliplaadist "Raid, Kaljo: Symphony No. 2, "Stockholm"; Tubin, Eduard: Elegy for Strings (arr. Raid). Symphony No. 11 (orch. Raid). Estonian State Symphony Orchestra, Arvo Volmer". Koch International Classics 37291-2 (48 minutes:DDD)

  10. Barber. Symphony N 1, Op. 9 / Michael Oliver

    Index Scriptorium Estoniae

    Oliver, Michael

    1991-01-01

    Uuest heliplaadist "Barber. Symphony N 1, Op. 9. The School for Scandal Overture, Op. 5 Beach. Symphony in E minor, Op. 32, "Gaelic". Detroit Symphony Orchestra /Neeme Järvi" Chandes cassette ABTD 1550; CD CHAN 8958 (72 minutes)

  11. Schnittke: Symphony N3. Stockholm Philharmonic Orchestra / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1990-01-01

    Uuest heliplaadist "Schnittke: Symphony N3. Stockholm Philharmonic Orchestra, Eri Klas. BIS/ Conifer CD 477 Schnittke: Concerto Grosso N4, Symphony N5. Gothenburg Symphony Orchestra, Neeme Järvi" BIS/ Conifer CD 427

  12. Svendsen Symphony No. 2 in B flat / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1994-01-01

    Uuest heliplaadist "Svendsen Symphony No. 2 in B flat, Op. 15... Stavanger Symphony Orchestra / Grant Llewellyn. Chatsworth CD FCM 1002; Symphony No. 2 - selected comparisons: Gothenburg SO, Järvi (11/87)(BIS) CD 347

  13. Mahler, G. Symphony N 5 / Johnson, Stephen

    Index Scriptorium Estoniae

    Johnson, Stephen

    1991-01-01

    Uuest heliplaadist "Mahler, G. Symphony N 5. Royal Liverpool Philharmonic Orchestra /Sir Charles Mackerras. EMI Eminence MC TC-EMx2164; CD-EMx2164 (70 minutes). Mahler. Symphony N 5. Royal Scottish National Orchestra /Neeme Järvi. Chandos MC ABTO 1454. CD CHAN 8829 (70 minutes). Sellected comparisons: VPO, Bernstein (8/88) New Phil., Barbiralli (11/88)

  14. IDM release behavior and surface characteristics of the novel Cu/IDM/LDPE nanocomposite for intrauterine device.

    Science.gov (United States)

    Yang, Zhihong; Xie, Changsheng; Xiang, Hua; Feng, Jinqing; Xia, Xianping; Cai, Shuizhou

    2009-03-01

    Copper/indomethacin/low-density polyethylene (Cu/IDM/LDPE) nanocomposite was prepared as a novel material for intra-uterine device (IUD). IDM release profile of the nanocomposite was investigated by using spectrophotometer. The results show that IDM release rate of Cu/IDM/LDPE nanocomposite is higher in simulated uterine solution than that in methanol, confirming that the release process of IDM is dominated mainly by pore diffusion. The decrease in copper particle size and the increase in copper mass content all accelerate IDM release, indicating that IDM release rate can be adjusted by changing copper loading or copper particle size. The surface of the incubated nanocomposite was characterized by X-ray diffraction, scanning electron microscopy and energy dispersive X-ray microanalysis. A few deposits composed of P, Cl, Ca, Cu and O were observed on the nanocomposite surface, which may be related to the presence of IDM particles with large particle size.

  15. Legal liability under an IDM program.

    Science.gov (United States)

    Wolfe, D L; Stanton, T J

    2000-12-01

    Integrated disability management (IDM) programs offer employers a simple, strategic approach to managing health and lost time. However, components of these programs also present potential liabilities under federal, and sometimes, state law. This article reviews the sources of these liabilities and summarizes techniques for minimizing the risk of employers (and managers individually).

  16. A Contextual Model for Identity Management (IdM) Interfaces

    Science.gov (United States)

    Fuller, Nathaniel J.

    2014-01-01

    The usability of Identity Management (IdM) systems is highly dependent upon design that simplifies the processes of identification, authentication, and authorization. Recent findings reveal two critical problems that degrade IdM usability: (1) unfeasible techniques for managing various digital identifiers, and (2) ambiguous security interfaces.…

  17. [Infants of diabetic mothers (IDM). I -- Macrosomia and growth factors].

    Science.gov (United States)

    Martín Carballo, G; Fernández Cano, G; Grande Aragón, C; Méndez Alavedra, J; Hawkins Carranza, F; Gracia Bouthelier, R

    1997-09-01

    The objective of this study was to determine the incidence of macrosomia in infants of diabetic mothers (IDM) and to analyze its possible correlation with insulin, C-peptide, growth hormone (GH) and IGF-I levels in umbilical cord blood. A prospective study of 58 IDM and 58 control newborns (33 males and 25 females in both groups) was carried out. The incidence of macrosomia was 25.8% in the IDM group and 61.5% in the IIDDM group (infant of insulin-dependent diabetic mother) compared to 5% in the control group. There was a positive correlation between maternal Hgb Alc levels in the third trimester of gestation and insulin and C-peptide levels with newborn weight in the IDM group (especially in the IIDDM group). IGF-I levels were positively correlated with newborn weight in both control and IDM groups. There was no correlation between GH and IGF-I levels in any group.

  18. IDM & iDM or the inert doublet model and inelastic dark matter

    Science.gov (United States)

    Arina, Chiara; Ling, Fu-Sin; Tytgat, Michel H. G.

    2009-10-01

    The annual modulation observed by DAMA/NaI and DAMA/Libra may be interpreted in terms of elastic or inelastic scattering of dark matter particles. In this paper we confront these two scenarios within the framework of a very simple extension of the Standard Model, the Inert Doublet Model (IDM). In this model the dark matter candidate is a scalar, the lightest component of an extra Higgs doublet. We first revisit the case for the elastic scattering of a light scalar WIMP, MDM ~ 10 GeV, a scenario which requires that a fraction of events in DAMA are channelled. Second we consider the possibility of inelastic Dark Matter (iDM). This option is technically natural in the IDM, in the sense that the mass splitting between the lightest and next-to-lightest neutral scalars may be protected by a Peccei-Quinn (PQ) symmetry. We show that candidates with a mass MDM between ~ 535 GeV and ~ 50 TeV may reproduce the DAMA data and have a cosmic abundance in agreement with WMAP. This range may be extended to candidates as light as ~ 50 GeV if we exploit the possibility that the approximate PQ symmetry is effectively conserved and that a primordial asymmetry in the dark sector may survive until freeze-out.

  19. Color Stability of IDM Composite Resin

    Directory of Open Access Journals (Sweden)

    Ghavam M

    2000-06-01

    Full Text Available Discoloration of composite resins is considered to be a major factor in esthetic restoration"nfailures. The aim of this study was to evaluate color stability of IDM composite (both light and self cure"nsamples namely IL and IS, and to compare it with a self-cure composite (Degufill named DS and a light"ncure ormocer composite (Definite, called DL in the Report. 60 disk shaped samples of each composite"nwere prepared, according to ISO-7491. The samples were divided into 3 groups and aged as follows:"nA- (Control 7 days in dark 37°c chamber"nB- Foil covered and kept in 100% humidity, and 37°c in xenotest chamber for 24 hours, then transferred"nto a dark 37°c chamber for 6 more days."nC- Kept in 37°c, 100% humidity under the emission of xiiion lamp of xenotest chamber for 24 hours,"nand then transferred to 37°c dark chamber for 6 more days"nThe lightness and chromaticity values of samples were measured both before and after aging using a"nspectrophotometer (Data Flash. The total color changes as well as changes in lightness and chromaticity"nvalues were measured in the CIE L * a * b * scale, and analyzed. Color change was recorded to be"nsignificant in all samples after aging. The maximum change belonged to IL, which was significantly"ndifferent from DL and DS. It seems, in order to have a durable esthetic restoration using IDM, more"nscientific and professional consideration is needed in the production process.

  20. [Infants of diabetic mothers (IDM). II -- Fibronectin and perinatal morbidity].

    Science.gov (United States)

    Martín Carballo, G; Codoceo Alquila, R; Fernández Cano, G; Hawkins Carranza, F; Grande Aragón, C; Velasco Hernando, A; Gracia Bouthelier, R

    1997-09-01

    The objective of this study was to determine fibronectin levels in umbilical cord blood of infants of diabetic mothers (IDM) and evaluate a possible correlation with perinatal pathology. A prospective study of 58 IDM (33 males and 25 females) and 58 control newborns (NB) (33 males and 25 females) was carried out. There were no differences in fibronectin levels between the two groups nor between the sexes. Perinatal morbidity was higher in the IDM group, but there was no correlation between fibronectin levels and the presence of perinatal pathology. Fibronectin levels are not useful in the perinatal evaluation of infants of diabetic mothers.

  1. Identity Management ToolKit (IdM TK)

    Data.gov (United States)

    Department of Veterans Affairs — With the IdM TK, authorized users can search and view identity and exception information from the Administrative Data Repository (ADR). Specifically, users can view...

  2. Investigation of symphony orchestra musicians' use of hearing protectors

    DEFF Research Database (Denmark)

    Poulsen, Torben; Koskinen, Heli

    2010-01-01

    A questionnaire study was performed about the use of hearing protectors in Danish symphony orchestras. The musicians in three Danish symphony orchestras were asked to complete a questionnaire about their use of hearing protection. A total of 146 musicians filled in the questionnaire. Results show...... an investigation is performed about the use of hearing aids as hearing protectors by symphony orchestra musicians. Preliminary results from this investigation will be presented at the conference....

  3. Stenhammar: Symphonies - No. 1 in F / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1995-01-01

    Uuest heliplaadist "Stenhammar: Symphonies - No. 1 in F, No. 2 in G minor, op. 34 Excelsior! Op. 13. Serenade in F, Op. 31. Gothenburg Symphony Orchestra / Neeme Järvi. DG CD 445 857-2 GH 2 (two discs: 139 minutes)

  4. L. Sumera: Symphony No. 5 / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1997-01-01

    L. Sumera: Symphony No. 5; Music for Chamber Orchestra, In memorian. Malmö Symphony Orchestra / Paavo Järvi. BIS CD-770. 64-35 DDD; Various. Searching for Roots - music from Estonia. Virgin VC 5 43242 2; 71: 34 DDD

  5. Symphony: SirsiDynix's Flagship Integrated Library System--A Horizon User's Perspective

    Science.gov (United States)

    Khurshid, Zahiruddin; Al-Baridi, Saleh

    2009-01-01

    At the end of 2007, SirsiDynix introduced the first version of Symphony, its new flagship Integrated Library System (ILS). This article begins with a look at the evolution of Symphony, user reactions to Symphony, and Symphony's design and functionality. The authors, along with a team of librarians from various functional areas, have completed…

  6. NY TBO Research: Integrated Demand Management (IDM): IDM Concept, Tools, and Training Package

    Science.gov (United States)

    Smith, Nancy

    2016-01-01

    A series of human-in-the-loop simulation sessions were conducted in the Airspace Operations Laboratory (AOL) to evaluate a new traffic management concept called Integrated Demand Management (IDM). The simulation explored how to address chronic equity, throughput and delay issues associated with New Yorks high-volume airports by operationally integrating three current and NextGen capabilities the Collaborative Trajectory Options Program (CTOP), Time-Based Flow Management (TBFM) and Required Time of Arrival (RTA) in order to better manage traffic demand within the National Air Traffic System. A package of presentation slides was developed to describe the concept, tools, and training materials used in the simulation sessions. The package will be used to outbrief our stakeholders by both presenting orally and disseminating of the materials via email.

  7. Die Hard as an Emotion Symphony

    DEFF Research Database (Denmark)

    Grodal, Torben Kragh

    2017-01-01

    The article will analyze how action films use different emotional sources of arousal to create narrative tension and suspense in the PECMA flow i.e. the mental flow of perceptions that activate emotions, cognition and action as described in Grodal 2009. It will analyze how different emotions link...... to each other or contrast each other in the narrative flow that you metaphorically might call an emotion symphony. The flow may create a time-out experience due to the way in which the action-oriented flow recruits consciousness in full, similar to the way in which music creates flow experiences...

  8. IDMS: inert dark matter model with a complex singlet

    Science.gov (United States)

    Bonilla, Cesar; Sokolowska, Dorota; Darvishi, Neda; Diaz-Cruz, J. Lorenzo; Krawczyk, Maria

    2016-06-01

    We study an extension of the inert doublet model (IDM) that includes an extra complex singlet of the scalars fields, which we call the IDMS. In this model there are three Higgs particles, among them a SM-like Higgs particle, and the lightest neutral scalar, from the inert sector, remains a viable dark matter (DM) candidate. We assume a non-zero complex vacuum expectation value for the singlet, so that the visible sector can introduce extra sources of CP violation. We construct the scalar potential of IDMS, assuming an exact Z 2 symmetry, with the new singlet being Z 2-even, as well as a softly broken U(1) symmetry, which allows a reduced number of free parameters in the potential. In this paper we explore the foundations of the model, in particular the masses and interactions of scalar particles for a few benchmark scenarios. Constraints from collider physics, in particular from the Higgs signal observed at the Large Hadron Collider with {M}h≈ 125 {{GeV}}, as well as constraints from the DM experiments, such as relic density measurements and direct detection limits, are included in the analysis. We observe significant differences with respect to the IDM in relic density values from additional annihilation channels, interference and resonance effects due to the extended Higgs sector.

  9. Early event-driven (EED) RTCP feedback for rapid IDMS

    NARCIS (Netherlands)

    Montagud, M.; Boronat, F.; Stokking, H.M.

    2013-01-01

    Inter-Destination Media Synchronization (IDMS) is essential in the emerging media consumption paradigm, which is radically evolving from passive and isolated services towards dynamic and interactive group shared experiences. This paper concentrates on improving a standardized RTP/RTCP-based solution

  10. A Geologic Symphony: Science, Artistic Inspiration and Community Engagement in Jeffrey Nytch's Symphony No 1: Formations

    Science.gov (United States)

    Nytch, J.

    2017-12-01

    While the natural world has inspired works of visual art and music for centuries, examples of music being created as a direct expression of scientific processes or principles are relatively rare. In his 2013 work, Symphony No. 1: Formations, composer Jeffrey Nytch created a work that explicitly communicated the geologic history of the Rocky Mountain west through a musical composition. Commissioned by the Geological Society of America and premiered at the GSA's 125th Anniversary meeting, the symphony is more than merely inspired by the Rocky Mountains; rather, specific episodes of geologic history are depicted in the music. Moreover, certain processes such as metamorphosis, erosion, vulcanism, plate tectonics, and the relative duration of geologic time guided the structure and form of the music. This unique approach to musical composition allowed the work to play a novel and potent role in community engagement and education, both at the premiere performances in Colorado and subsequent performances of the symphony elsewhere. This project is thus a powerful example of how the arts can help illuminate scientific principles to the general public, in turn engaging them and helping to establish a more personal connection to the natural world around them.

  11. Commentary on "Sonata Form in the Nineteenth-Century Symphony"

    Directory of Open Access Journals (Sweden)

    Ben Duane

    2017-01-01

    Full Text Available This commentary compares observational corpus analysis and hypothesis-driven analytical methods, and discusses the methods used in Cannon's "Sonata Form in the Nineteenth-Century Symphony" article.

  12. Hearing ability in Danish symphony orchestra musicians

    DEFF Research Database (Denmark)

    Obeling, Lise; Poulsen, Torben

    1999-01-01

    equipment placed in various instrument groups. The average audiogram showed a decrease at higher frequencies similar to an age-related hearing loss. Each audiogram was corrected for the age of the person by means of the median from ISO 7029 and the average audiogram from these age-corrected individual...... audiograms showed no signs of hearing loss. The audiograms were also compared to the expected audiograms from ISO 1999, which takes account of the number of years at work, the number of playing hours per week, and the average sound level in the orchestra for the instrument group. In almost all cases...... the measured audiograms looked better than the predictions from ISO 1999. It may be concluded from this investigation that musicians cannot be expected to get pronounced audiometric hearing losses from playing in a symphony orchestra. It should be noted, though, that the data material is limited...

  13. Multimodal Biometrics and Multilayered IDM for Secure Authentication

    Science.gov (United States)

    Rashed, Abdullah; Santos, Henrique

    In the Electronic Society (e-world) users are represented by a set of data called Digital Identity (ID), which they must use for authentication purposes. Within the e-world it is certainly risky to lose the identity and this security threat must be ranking with the highest priority, forcing a solution that provides an amenable usage of digital identity. Efficient protection of the digital identity would also encourage users to enter the digital world without worries. Security needs to provide the necessary identity management (IDM) process to mitigate that threat. This paper gives an overview of IDM and suggests a framework that can be particularly useful for a secure user authentication. The proposed model appears as a multi-layered security approach, since it tries to integrate different security technologies and multimodal biometrics tools and practices, such as police, procedures, guidelines, standards and legislation. The advantages, limitations and requirements of the proposed model are discussed.

  14. Entitlement Management: Ready to Enter the IdM Mainstream

    Science.gov (United States)

    Gebel, Gerry; Wang, Alice

    Externalizing authorization processing from business applications has been a goal for architects and developers for many years. Recent compliance demands for more granular access control and policy transparency have increased the urgency to adopt an architectural model where authorization and entitlement management are consumed as a service rather than embedded within business applications. Major software vendors, such as Microsoft, Oracle, and SAP, are making significant steps to separate IdM functionality, including entitlement management from application logic. The market has also responded with a plethora of products that provide entitlement management and authorization functionality for commercial or custom-built application environments. Finally, the Extensible Access Control Markup Language (XACML) has emerged as the consensus authorization standard being supported by a growing number of IT and application vendors. Collectively, these forces form the basis of a nascent IdM market segment referred to as entitlement management.

  15. Stravinsky: Symphony in E flat, Op. 1. Firebird-Suite (1919 version / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1994-01-01

    Uuest heliplaadist "Stravinsky: Symphony in E flat, Op. 1. Firebird-Suite (1919 version). Royal Philharmonic Orchestra / Dalia Atlas; Symphony - comparative versions: SNO, Gibson. SRO, Järvi (2/94)(CHAN) CHAN 9236

  16. Grieg: Works for String Orchestra. Gothenburg Symphony Orchestra, Neeme Järvi / Sanders, Alan

    Index Scriptorium Estoniae

    Sanders, Alan

    1993-01-01

    Uuest heliplaadist "Grieg: Works for String Orchestra. Gothenburg Symphony Orchestra, Neeme Järvi. CD 437 520 - 2GH Grieg: Land Sighting, Op.32, Olav Trygvason, Op.50, Per Gynt Suites N1,Op.46, N2,Op.55. Randi Stene, Anne Gjevang, Hakan Hagegard, Gothenburg Symphony Chorus, Gothenburg Symphony Orchestra, Neeme Järvi. CD 437 523 - 2 GH

  17. A symphony of data at LHCb

    CERN Multimedia

    2008-01-01

    Like musical instruments in an orchestra, the main difficulty with the many detectors of LHCb is coaxing them into playing in harmony. On 8 February 2008, for the first time, the LHCb control room team managed to extract a symphony of data from an almost complete ensemble of LHCb detectors. The LHCb control room team examining the data read out from the LHCb detectors. General view of the LHCb detector components.Now that all the detectors of LHCb are installed in the cavern they can begin to play a tune. The week of 4 February was commissioning week for the LHCb control room, when, for the first time, data from the majority of the sub-detectors (VELO, RICH 1, RICH 2, ECAL, HCAL, MUON, L0Calo and L0DU) was read out, controlled from a single window on the main computer. Sixty electronic boards, which read out the fragments of triggered events, were used during the readout at a frequency of 100 Hz. As not all of the boards ...

  18. Increasing security and privacy in user-centric identity management: The IdM card approach

    OpenAIRE

    Marx, R.; Simo Fhom, H.; Scheuermann, D.; Bayarou, K.M.; Perez, A.

    2010-01-01

    In this paper, we describe how security and privacy can be increased in user-centric Identity Management (IdM) by the introduction of a so-called IdM card. This IdM card securely stores and processes identity data of the card owner, an end user. The card represents a trusted device that supports the user in managing its digital identities and also in performing secure and privacy-enhanced service authentication and authorization.

  19. Rimsky-Korsakov: Symphony N2 (Symphonic Suite) / Warrack, John

    Index Scriptorium Estoniae

    Warrack, John

    1990-01-01

    Uuest heliplaadist "Rimsky-Korsakov: Symphony N2 (Symphonic Suite), Op. 9, "Antar" Russian Easter Festival Overture, Op.36. Philharmonia Orchestra, Evgeni Svetlanov. Hyperion KA 66399. CDA 66399. Teise sümfoonia esitust võrreldud Neeme Järvi plaadistusega

  20. Borodin: Les 3 Symphonies. Le Prince Igor / Francis Dresel

    Index Scriptorium Estoniae

    Dresel, Francis

    1992-01-01

    Uuest heliplaadist "Borodin: Les 3 Symphonies. Le Prince Igor: Ouverture. Danse des jeunes filles polovtsiennes. Danses polovtsiennes. Notturno. Dans les Steppes de l'Asie centrale. Petite Suite. Choeur et Orchestre Symphonique de Göteborg, Neeme Järvi" DG 435 757-2

  1. Hearing Protection and Hearing Symptoms in Danish Symphony Orchestras

    DEFF Research Database (Denmark)

    Laitinen, Heli; Poulsen, Torben

    2006-01-01

    A study about hearing protectors, problems involving hearing protector usage, hearing problems and working surroundings of classical musicians was made in three Danish symphony orchestras. The questionnaire used in the study was based on a previous study, a study made in Sweden to rock musicians,...

  2. Stravinsky: Symphonies, Concertos, Ballets and other works / David S. Gutman

    Index Scriptorium Estoniae

    Gutman, David S.

    1994-01-01

    Uuest heliplaadist "Stravinsky: Symphonies, Concertos, Ballets and other works. Gabriele Schnaut (sop), Peter Svensson (ten), Franz Grundheber (bar), Günther von Kannen (bass), Jean Piat (narr), Lydia Mordkovitch (vn), Geoffrey Tozer, Boris Berman (pfs), Suisse Romande Chamber Choir, Lausanne Pro Arte Choir, Brassus Choral Society, Suisse Romande Ochestra, Neeme Järvi. Chandos CD CHAN 9240

  3. Clock synchronisation experiment in India using symphonie satellite

    Science.gov (United States)

    Somayajulu, Y. V.; Mathur, B. S.; Banerjee, P.; Garg, S. C.; Singh, L.; Sood, P. C.; Tyagi, T. R.; Jain, C. L.; Kumar, K.

    1979-01-01

    A recent clock synchronization experiment between the National Physical Laboratory (NPL), New Delhi and Space Applications Center (SAC), Ahemedabad, in India via geostationary satellite symphonie 2, stationed at 49 E longitude, is reported. A two-way transmission using a microwave transponder considered to provide the greatest precision in synchronization of two remote clocks is described.

  4. Automated spike preparation system for Isotope Dilution Mass Spectrometry (IDMS)

    International Nuclear Information System (INIS)

    Maxwell, S.L. III; Clark, J.P.

    1990-01-01

    Isotope Dilution Mass Spectrometry (IDMS) is a method frequently employed to measure dissolved, irradiated nuclear materials. A known quantity of a unique isotope of the element to be measured (referred to as the ''spike'') is added to the solution containing the analyte. The resulting solution is chemically purified then analyzed by mass spectrometry. By measuring the magnitude of the response for each isotope and the response for the ''unique spike'' then relating this to the known quantity of the ''spike'', the quantity of the nuclear material can be determined. An automated spike preparation system was developed at the Savannah River Site (SRS) to dispense spikes for use in IDMS analytical methods. Prior to this development, technicians weighed each individual spike manually to achieve the accuracy required. This procedure was time-consuming and subjected the master stock solution to evaporation. The new system employs a high precision SMI Model 300 Unipump dispenser interfaced with an electronic balance and a portable Epson HX-20 notebook computer to automate spike preparation

  5. Nuclear power in the WEC partitions: Jazz and symphony - 5404

    International Nuclear Information System (INIS)

    Moncomble, J.E.

    2015-01-01

    The World Energy Council (WEC) has built two scenarios typified by characteristics, which, each from their own perspective, may comprehensively describe large parts of the world in 2050: the more consumer-driven Jazz scenario and the more voter-driven Symphony scenario. While scenarios are 'music based', they are completely different in nature. As an energy scenario, Jazz has a focus on energy equity with priority given to achieving individual access and affordability of energy through economic growth. As an energy scenario, Symphony has a focus on achieving environmental sustainability through internationally coordinated policies and practices. These scenarios are designed to help a range of stakeholders address the 'energy tri-lemma' of achieving environmental sustainability, energy security, and energy equity. The energy landscape we expect to see in 2050 will be quite different from how it looks today. Meeting future energy demand will be a key challenge. The world's population will increase from approximately 7 billion in 2013 to approximately 8.7 billion in the Jazz scenario and approximately 9.4 billion in the Symphony scenario in 2050, which is equal to a 26% increase (36% respectively). The WEC estimates that total primary energy supply (equal to consumption) will increase globally from 546 EJ (152 PWh) in 2010 to 879 EJ (144 PWh) in the Jazz scenario and 696 EJ (193 PWh) in the Symphony scenario in 2050. This corresponds to an increase of 61% in Jazz and 27% in Symphony. In WEC Scenarios to 2050, nuclear energy will contribute approximately 4% of total primary energy supply in Jazz in 2050 and 11% in Symphony - compared to 6% in 2010. More precisely, there is an increase of nuclear capacity (even in Jazz, thanks to demand increase) from 373 GW in 2010 to 481 GW (Jazz) or 884 GW (Symphony) in 2050. Electricity generation from renewable sources (RES-E) will increase around 4 to 5 times by 2050 in comparison to 2010

  6. Astroparticle Physics - A Joint TeVPA/ IDM Conference

    CERN Document Server

    2014-01-01

    Astroparticle Physics: a joint IDM/TeVPA event brings together two major international conference series in Astroparticle Physics:Identification of Dark Matter andTeV Particle Astrophysics. We aim to provide the stage for the most recent advances in the booming field of Astroparticle Physics, bringing to Amsterdam - a city that has recently invested a lot into this research area through initiatives like GRAPPA and the D-ITP - leading members of the scientific communities that are contributing to its success. The topics of the conference will include: Cosmic Rays Dark Matter in Cosmology Direct Dark Matter Searches Indirect Dark Matter Searches High Energy Particle Physics Neutrinos High Energy Astrophysics The conference will be held at the Tuschinski Theatre, an extraordinary landmark built in 1921 in the heart of Amsterdam in a spectacular mix of Amsterdam School, Jugendstil, Art Nouveau and Art Deco. The main auditorium, which hosts many premieres of Dutch fi...

  7. Radiation load experiments with electronic components of the SYMPHONIE satellite

    International Nuclear Information System (INIS)

    Spencker, A.; Wagemann, H.G.; Braeunig, D.

    1975-09-01

    This report surveys fundamentals, realization and results of irradiation experiments which applied to 36 different electronic components of the Symphonie satellite and which were completed at the HMI Berlin and the C.N.E.T. Lannion in the years 1972/73. In a general section the evaluation of equivalent fluencies concerning 1 MeV electrons as radiation simulating the extraterrestric particle spectra with regard to the well-known semiconductor damage mechanisms is discussed. Then the realization of irradiation testing for the Symphonie satellite is described. Three selected examples demonstrate typical failure modes of semiconductor devices under radiation stress: Finally the main experimental results are shown in a standardized manner; a survey in English is given on p. 44. (orig.) [de

  8. Solar System Symphony: Combining astronomy with live classical music

    Science.gov (United States)

    Kremer, Kyle; WorldWide Telescope

    2017-01-01

    Solar System Symphony is an educational outreach show which combines astronomy visualizations and live classical music. As musicians perform excerpts from Holst’s “The Planets” and other orchestral works, visualizations developed using WorldWide Telescope and NASA images and animations are projected on-stage. Between each movement of music, a narrator guides the audience through scientific highlights of the solar system. The content of Solar System Symphony is geared toward a general audience, particularly targeting K-12 students. The hour-long show not only presents a new medium for exposing a broad audience to astronomy, but also provides universities an effective tool for facilitating interdisciplinary collaboration between two divergent fields. The show was premiered at Northwestern University in May 2016 in partnership with Northwestern’s Bienen School of Music and was recently performed at the Colburn Conservatory of Music in November 2016.

  9. Perancangan Interior Sekolah Musik Surabaya Symphony Orchestra Di Surabaya

    OpenAIRE

    Grace Mulyono, Liliyana Tan IGN. Ardana

    2016-01-01

    Classical music has a lot of benefits that can make more optimal brain development. Surabaya Symphony Orchestra Music School is a place to facilitate society in Surabaya to learn classical music.Many activities that can support learning classical music has not been facilitated due to the limited area, and lack of interior on SSO create interest and learning music became blocked. In accordance with Dolce concept which means “to play sweetly”, the music school design is using bright colors with...

  10. Experience of determination of plutonium and uranium contents in MOX fuel by IDMS

    International Nuclear Information System (INIS)

    Yoshida, Mika; Suzuki, Toru; Kobayashi, Hideo; Ohtani, Tetsuo

    2001-01-01

    In the Plutonium Fuel Center (PFC) of JNC, Isotope Dilution Mass Spectrometry (IDMS) has been used to determine Pu and U contents of nuclear materials since 1996. In MOX fabrication plant, many types of sample with wide variation of Pu/U ratio including aged Pu and process scrap should be analyzed for not only quality control purpose but also material accountancy. Because IDMS can eliminate influences of coexistence elements and has high accuracy, it is considered to be the best analytical method for MOX fabrication plant. This paper summarizes the experience of IDMS in the PFC laboratory including the preparation of Large Size Dried (LSD) spike, and also describes the evaluation of analytical error and consideration on procurement of LSD spike for IDMS

  11. A large data base on a small computer. Neutron Physics data and bibliography under IDMS

    International Nuclear Information System (INIS)

    Schofield, A.; Pellegrino, L.; Tubbs, N.

    1978-01-01

    The transfer of three associated files to an IDMS data base is reported: the CINDA bibliographic index to neutron physics publications, the cumulated EXFOR exchange tapes used for maintaining parallel data collections at all four centres and the CCDN's internal data storage and retrieval system NEUDADA. With associated dictionaries and inter-file conversion tables the corresponding IDMS data base will be about 160 Mbytes. The main characteristics of the three files are shown

  12. Interrupting the Symphony: Unpacking the Importance Placed on Classical Concert Experiences

    Science.gov (United States)

    Hess, Juliet

    2018-01-01

    The Toronto Symphony Orchestra presents a series of youth concerts each year to introduce and attract younger audiences to the symphony. Music teachers often attend these concerts with students, and the importance of such experiences is frequently emphasised and normalised. This article explores the historical roots of the following relations,…

  13. Hearing loss in relation to sound exposure of professional symphony orchestra musicians

    DEFF Research Database (Denmark)

    Schmidt, J. H.; Pedersen, E. R.; Paarup, H. M.

    2014-01-01

    OBJECTIVES: The objectives of this study were to: (1) estimate the hearing status of classical symphony orchestra musicians and (2) investigate the hypothesis that occupational sound exposure of symphony orchestra musicians leads to elevated hearing thresholds. DESIGN: The study population...... that performing music may induce hearing loss to the same extent as industrial noise....

  14. Chadwick: Symphony No. 3 in F; Barber: Vanessa-Intermezzo / Andrew Achenbach

    Index Scriptorium Estoniae

    Achenbach, Andrew

    1994-01-01

    Uuest heliplaadist "Chadwick: Symphony No. 3 in F; Barber: Vanessa-Intermezzo, Under the Willow Tree. Music for a scene from Shelley, Op. 7. Medea's Meditation and Dance of Vengeance, Op. 23a. Detroit Symphony Orchestra / Neeme Järvi." Chandos CD CHAN 9253

  15. Berwald. Symphonies - No. 1 in G minor, "Sinfonie serieuse" / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1996-01-01

    Uuest heliplaadist "Berwald. Symphonies - No. 1 in G minor, "Sinfonie serieuse". No. 2 in D, "Sinfonie singuliere". No. 4 in E flat. Gothenburg Symphony Orchestra, Neeme Järvi. DG Masters 445 581-26 MA2 (two discs: 112 minutes: DDD)

  16. Searching for Roots. Pärt: Symphony No. 1, "Polyphonic" / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1997-01-01

    Uuest heliplaadist "Searching for Roots. Pärt: Symphony No. 1, "Polyphonic". Nekrolog, Op. 3; Tubin: Symphony No. 11; Tüür: Searching for Roots. Insula deserta. Zeitraum. Royal Stockholm Philharmonic Orchestra / Paavo Järvi. Virgin Classics VC5 45212-2 (72 min.:DDD)

  17. Microscale Quantitative Analysis of Polyhydroxybutyrate in Prokaryotes Using IDMS.

    Science.gov (United States)

    Velasco Alvarez, Mariana Itzel; Ten Pierick, Angela; van Dam, Patricia T N; Maleki Seifar, Reza; van Loosdrecht, Mark C M; Wahl, S Aljoscha

    2017-05-17

    Poly(3-hydroxybutyrate) (PHB) is an interesting biopolymer for replacing petroleum-based plastics, its biological production is performed in natural and engineered microorganisms. Current metabolic engineering approaches rely on high-throughput strain construction and screening. Analytical procedures have to be compatible with the small scale and speed of these approaches. Here, we present a method based on isotope dilution mass spectrometry (IDMS) and propanolysis extraction of poly(3-hydroxybutyrate) from an Escherichia coli strain engineered for PHB production. As internal standard (IS), we applied an uniformly labeled 13 C-cell suspension, of an E. coli PHB producing strain, grown on U- 13 C-glucose as C-source. This internal 13 C-PHB standard enables to quantify low concentrations of PHB (LOD of 0.01 µg/g CDW ) from several micrograms of biomass. With this method, a technical reproducibility of about 1.8% relative standard deviation is achieved. Furthermore, the internal standard is robust towards different sample backgrounds and dilutions. The early addition of the internal standard also enables higher reproducibility and increases sensitivity and throughput by simplified sample preparation steps.

  18. Microscale Quantitative Analysis of Polyhydroxybutyrate in Prokaryotes Using IDMS

    Directory of Open Access Journals (Sweden)

    Mariana Itzel Velasco Alvarez

    2017-05-01

    Full Text Available Poly(3-hydroxybutyrate (PHB is an interesting biopolymer for replacing petroleum-based plastics, its biological production is performed in natural and engineered microorganisms. Current metabolic engineering approaches rely on high-throughput strain construction and screening. Analytical procedures have to be compatible with the small scale and speed of these approaches. Here, we present a method based on isotope dilution mass spectrometry (IDMS and propanolysis extraction of poly(3-hydroxybutyrate from an Escherichia coli strain engineered for PHB production. As internal standard (IS, we applied an uniformly labeled 13C-cell suspension, of an E. coli PHB producing strain, grown on U-13C-glucose as C-source. This internal 13C-PHB standard enables to quantify low concentrations of PHB (LOD of 0.01 µg/gCDW from several micrograms of biomass. With this method, a technical reproducibility of about 1.8% relative standard deviation is achieved. Furthermore, the internal standard is robust towards different sample backgrounds and dilutions. The early addition of the internal standard also enables higher reproducibility and increases sensitivity and throughput by simplified sample preparation steps.

  19. Creatinine Assay Attainment of Analytical Performance Goals Following Implementation of IDMS Standardization

    Directory of Open Access Journals (Sweden)

    Elizabeth Sunmin Lee

    2017-02-01

    Full Text Available Background: The international initiative to standardize creatinine (Cr assays by tracing reference materials to Isotope Dilution Mass Spectrometry (IDMS assigned values was implemented to reduce interlaboratory variability and improve assay accuracy. Objective: The aims of this study were to examine whether IDMS standardization has improved Cr assay accuracy (bias, interlaboratory variability (precision, total error (TE, and attainment of recommended analytical performance goals. Methods: External Quality Assessment (EQA data (n = 66 challenge vials from Ontario, Canada, were analyzed. The bias, precision, TE, and the number of EQA challenge vials meeting performance goals were determined by assay manufacturer before (n = 32 and after (n = 34 IDMS implementation. Results: The challenge vials with the worst bias and precision were spiked with known common interfering substances (glucose and bilirubin. IDMS standardization improved assay bias (10.4%-1.6%, P < .001, but precision remained unchanged (5.0%-4.7%, P = .5 with performance goals not consistently being met. Precision and TE goals based on biologic variation were attained by only 29% to 69% and 32% to 62% of challenge vials. Conclusions: While IDMS standardization has improved Cr assay accuracy and thus reduced TE, significant interlaboratory variability remains. Contemporary Cr assays do not currently meet the standards required to allow for accurate and consistent estimated glomerular filtration rate assessment and chronic kidney disease diagnosis across laboratories. Further improvements in Cr assay performance are needed.

  20. Chitosan/alginate multilayer film for controlled release of IDM on Cu/LDPE composite intrauterine devices.

    Science.gov (United States)

    Tian, Kuan; Xie, Changsheng; Xia, Xianping

    2013-09-01

    To reduce such side effects as pain and bleeding caused by copper-containing intrauterine device (Cu-IUD), a novel medicated intrauterine device, which is coated with an indomethacin (IDM) delivery system on the surface of copper/low-density polyethylene (Cu/LDPE) composite intrauterine device, has been proposed and developed in the present work. The IDM delivery system is a polyelectrolyte multilayer film, which is composed of IDM containing chitosan and alginate layer by layer, is prepared by using self-assembled polyelectrolyte multilayer method, and the number of the layers of this IDM containing chitosan/alginate multilayer film can be tailored by controlling the cyclic repetition of the deposition process. After the IDM containing chitosan/alginate multilayer film is obtained on the surface of Cu/LDPE composite intrauterine device, its release behavior of both IDM and cupric ion has been studied in vitro. The results show that the release duration of IDM increase with the increasing of thickness of the IDM containing chitosan/alginate multilayer film, and the initial burst release of cupric ion cannot be found in this novel medicated Cu/LDPE composite IUD. These results can be applied to guide the design of novel medicated Cu-IUD with minimal side effects for the future clinical use. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. The CRRES IDM spacecraft experiment for insulator discharge pulses. [Internal Discharge Monitor

    Science.gov (United States)

    Frederickson, A. R.; Mullen, E. G.; Kerns, K. J.; Robinson, P. A.; Holeman, E. G.

    1993-01-01

    The Internal Discharge Monitor (IDM) is designed to observe electrical pulses from common electrical insulators in space service. The characteristics of the instrument are described. The IDM was flown on the Combined Release and Radiation Effects Satellite (CRRES). The sixteen insulator samples included G10 circuit boards, FR4 and PTFE fiberglass circuit boards, FEP Teflon, alumina, and wires with common insulations. The samples are fully enclosed, mutually isolated, and space radiation penetrates 0.02 cm of aluminum before striking the samples. Published data in the literature provides a simple method for determining the flux of penetrating electrons. The pulse rate is compared to the penetrating flux of electrons.

  2. Alfven. Symphony No 5 in A minor, Op. 54 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1994-01-01

    Uuest heliplaadist "Alfven. Symphony No 5 in A minor, Op. 54. The Mountain King - Suite, Gustav II Adolf, Op. 49 - Elegy. Royal Stockholm Philarmonic Orchestra / Neeme Järvi. BIS CD 585 (68 minutes) Recorded in association with Trygg Hansa"

  3. Prokofiev: Symphony No. 6 in E flat, Op. 111 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1994-01-01

    Uuest heliplaadist "Prokofiev: Symphony No. 6 in E flat, Op. 111; Stravinsky:Petrushka (1911 version). Leningrad Philharmonic Orchestra / Evgeny Mravinsky; Prokofiev - selected comparison: SNO, Järvi (7/85)(CHAN) CHAN 8359

  4. Tchaikovsky: Symphony No. 5 in E minor, Op. 64 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1994-01-01

    Uuest heliplaadist "Tchaikovsky: Symphony No. 5 in E minor, Op. 64; Rimsky-Korsakov: Russian Easter Festival Overture, Op. 36. Philharmonia Orchestra / Giuseppe Sinopoli; Overture - selected comparison: Gothenburg SO, Järvi (3/91) DG 429984-2GH

  5. Brahms J. Hungarian Dances. London Symphony Orchestra, Neeme Järvi / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Brahms J. Hungarian Dances. London Symphony Orchestra, Neeme Järvi. Chandos MC ABTD 1496; CD CHAN 8885 (57 minutes). Brahms J. Hungarian Dances. Staatskapelle Berlin. Otmar Suitner." Denon CD CO- 74597 (53 minutes)

  6. Accurate quantification of total chromium and its speciation form Cr(VI) in water by ICP-DRC-IDMS and HPLC/ICP-DRC-IDMS.

    Science.gov (United States)

    Markiewicz, Barbara; Komorowicz, Izabela; Barałkiewicz, Danuta

    2016-05-15

    Two analytical procedures have been developed for the determination of total chromium (TCr) and its highly toxic species, i.e. Cr(VI) in water samples using the following methods: inductively coupled plasma dynamic reaction cell isotope dilution mass spectrometry (ICP-DRC-IDMS) and high performance liquid chromatography inductively coupled plasma dynamic reaction cell isotope dilution mass spectrometry (HPLC/ICP-DRC-IDMS). Spectral interferences, predominantly occurring in chromium determination, were removed using a dynamic reaction cell (DRC). The presented procedures facilitate the quantification of trace amounts - below 1 µg L(-1) of TCr and individual Cr species - in various water matrices including drinking water and still bottled water with different mineral composition. Special attention has been paid to the adequate preparation of isotopically enriched (53)Cr(VI) standard solution in order to avoid artifacts in chromium speciation. Both procedures were fully validated as well as establishing the traceability and estimation of the uncertainty of measurement were carried out. Application of all of the above mentioned elements and of the isotope dilution technique, which provides the highest quality of metrological traceability, allowed to obtain reliable and high quality results of chromium determination in water samples. Additionally, the comparison of two methods: HPLC/ICP-DRC-MS and HPLC/ICP-DRC-IDMS for Cr(VI) determination, was submitted basing on the validation parameters. As a result, the lower values for these parameters were obtained using the second method. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Distortion product otoacoustic emission fine structure of symphony orchestra musicians

    DEFF Research Database (Denmark)

    Reuter, Karen; Hammershøi, Dorte

    2006-01-01

    losses than puretone audiometry. The distortion product otoacoustic emission (DPOAE) fine structure is obtained when the ear is stimulated by dual tone stimuli using a high frequency resolution. It is characterized by quasi-periodic variations across frequency, as it can be observed in the hearing...... threshold microstructure also. In this study DPOAE fine structures and hearing thresholds are obtained for symphony orchestra musicians both for left and right ears and before and after the orchestra rehearsal. DPOAE fine structures are analyzed with an automatic classification algorithm, which describes...... the ripple pattern by parameters. A difference between left and right ears could be detected for the DPOAE level but not for the fine structure parameters. No difference between the measures taken before and after exposure could be observed....

  8. Opacity and Color Changes of Light-Cured Ideal Makoo (IDM

    Directory of Open Access Journals (Sweden)

    M.Ghavam

    2004-03-01

    Full Text Available Statement of Problem: Esthetic materials undergo some physical and mechanical changes,during their service in oral cavity.Purpose: The aim of this study was the evaluation of the color and opacity stability of Ideal Makoo (IDM composites and compare it with Tetric ceram.Material and methods: Fifteen disk shaped samples of each material was divided into three groups of five. Different aging treatments were applied to each group. The contrast ratio of 1mm thickness and rE of the samples were evaluated at base line and after aging,using CIE system and Data Flash spectrophotometer. All the samples were kept at 37°C.Results: Baseline opacity of IDM was relatively high (77.60%±8.6. Both materials showed increased opacity after aging. The highest rE belonged to IDM samples of B group, which was significantly more than Tetric Ceram (P<0.05. Tetric Ceram, also showed some degree of color change (rE=4.60 and 5.79, on black and white background,respectively, which is noticeable clinically.Conclusion: The research showed that IDM can not be a reliable esthetic material, unless some improvements in the chemical composition will be achieved.

  9. 77 FR 40515 - Safety Zone; Detroit Symphony Orchestra at Ford House Fireworks, Lake St. Clair, Grosse Pointe...

    Science.gov (United States)

    2012-07-10

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Detroit Symphony Orchestra at Ford House... Detroit Symphony Orchestra at the Ford House Fireworks. This zone will be effective and enforced from 10... Orchestra at Ford House Fireworks, Lake St. Clair, Grosse Pointe Shores, MI (a) Location. The safety zone...

  10. Seismic behaviour of LMFBR reactor cores. The SYMPHONY program

    International Nuclear Information System (INIS)

    Broc, Daniel

    2001-01-01

    As part of a comprehensive program on the seismic behaviour of the LMFBR reactor cores, the SYMPHONY experimental program, performed at the CEA Saclay, is carried out from 1993 up to now. LMFBR reactor cores are composed of fuel assemblies and neutronic shields, immersed in sodium (the primary coolant) or water (for the experimental tests). The main objective of the seismic studies is to evaluate the assembly motions, with consequences on the reactivity and the control rod insertability, and to verify the structural integrity of the assemblies under the impact forces. The experimental program has reached its objectives. Tests have been performed in a satisfying way. Instrumentation allowed to collect displacements, accelerations, and shock forces. All the results constitute a comprehensive base of valuable and reliable data. The interpretation of the tests is based on beam models, taking into account the Fluid Structure Interaction, and the shocks between the assemblies. Theoretical results are in a quite good agreement with the experimental ones. The interpretation of the hexagonal tests in water pointed out very strong coupling between the assemblies and lead to the development of a specific Fluid Structure Interaction, taking into account not only inertial effects, but dissipative effects also. (author)

  11. IDM as a "Minor" Literature: The Treatment of Cultural and Musical Norms by "Intelligent Dance Music"

    Directory of Open Access Journals (Sweden)

    Ramzy Alwakeel

    2009-09-01

    Full Text Available This piece opens with a consideration of the etymology and application of the term “IDM”, before examining the treatment of normative standards by the work associated therewith. Three areas in particular will be focused upon: identity, tradition, and morphology. The discussion will be illuminated by three case studies, the first of which will consider Warp Records’ relationship to narrative; the two remaining will explore the work of Autechre and Aphex Twin with some reference to the areas outlined above. The writing of Deleuze and Guattari will inform the ideas presented, with particular focus being made upon the notions of “minority”, “deterritorialisation”, and “continuous variation”. Based upon the interaction of the wider IDM “text” with existing “constants”, and its treatment of itself, the present work will conclude with the suggestion that IDM be read as a “minor” literature.

  12. Einstein's Symphony: A Gravitational Wave Voyage Through Space and Time

    Science.gov (United States)

    Shapiro Key, Joey; Yunes, Nico; Grimberg, Irene

    2015-01-01

    Einstein's Symphony: A Gravitational Wave Voyage Through Space and Time is a gravitational wave astronomy planetarium show in production by a collaboration of scientists, filmmakers, and artisits from the Center for Gravitational Wave Astonomy (CGWA) at the University of Texas at Brownsville (UTB) and Montana State University (MSU). The project builds on the success of the interdisciplinary Celebrating Einstein collaboration. The artists and scientists who created the A Shout Across Time original film and the Black (W)hole immersive art installation for Celebrating Einstein are teaming with the Museum of the Rockies Taylor Planetarium staff and students to create a new full dome Digistar planetarium show that will be freely and widely distributed to planetaria in the US and abroad. The show uses images and animations filmed and collected for A Shout Across Time and for Black (W)hole as well as new images and animations and a new soundtrack composed and produced by the MSU School of Music to use the full capability of planetarium sound systems. The planetarium show will be narrated with ideas drawn from the Celebrating Einstein danced lecture on gravitational waves that the collaboration produced. The combination of products, resources, and team members assembled for this project allows us to create an original planetarium show for a fraction of the cost of a typical show. In addition, STEM education materials for G6-12 students and teachers will be provided to complement and support the show. This project is supported by the Texas Space Grant Consortium (TSGC), Montana Space Grant Consortium (MSGC), and the American Physical Society (APS).

  13. Rimsky-Korsakov: Symphony N2 (Symphonic Suite), Op. 9 / John Warrack

    Index Scriptorium Estoniae

    Warrack, John

    1990-01-01

    Uuest heliplaadist "Rimsky-Korsakov: Symphony N2 (Symphonic Suite), Op. 9, "Antar" Russian Easter Festival Overture, Op.36. Philharmonia Orchestra, Evgeni Svetlanov" Hyperion KA 66399. CDA 66399. Teise sümfoonia esitust võrreldud Neeme Järvi plaadistusega

  14. A cross-sectional study of psychosocial work environment and stress in the Danish symphony orchestras.

    Science.gov (United States)

    Holst, Gitte Juel; Paarup, Helene M; Baelum, Jesper

    2012-08-01

    To investigate psychosocial work environment and stress in Danish symphony orchestra musicians. This was a cross-sectional questionnaire survey of psychosocial work factors and stress symptoms among 441 musicians in six Danish symphony orchestras. The response rate was 78% (n = 342). The questions were from COPSOQ (Copenhagen Psychosocial Questionnaire). Mean values of 19 COPSOQ-scales were compared by gender and instrument group. The results for the musicians were compared with results for the general Danish work force (COPSOQ database). Female musicians reported higher work demands and higher stress symptoms than their male colleagues. Between instrument groups, 2nd violinists seemed to be of particular risk compared with the other instrumental groups in aspects of work pace, work organization, and content, whereas 1st violinists perceived higher emotional stress compared with 2nd violinists. The musicians' experience of increased work demands as well as deteriorated, work organization and job content, interpersonal relations and leadership, and work-individual interface was significantly associated with increasing stress symptoms. Compared to the general workforce independently of gender, Danish symphony orchestra musicians reported higher emotional demands, lower influence, lower social support, lower sense of community, and lower job satisfaction. However, the musicians reported a higher commitment to the workplace. The findings indicate a more demanding psychosocial work environment exposure among symphony orchestra musicians than among Danish workers in general. Critical results are the relatively high work demands, low influence, and low social support, females being of higher risk than males.

  15. Noise induced hearing loss and other hearing complaints among musicians of symphony orchestras

    NARCIS (Netherlands)

    Jansen, E.J.M.; Helleman, H.W.; Dreschler, W.A.; de Laat, J.A.P.M.

    2009-01-01

    OBJECTIVES: An investigation of the hearing status of musicians of professional symphony orchestras. Main questions are: (1) Should musicians be treated as a special group with regard to hearing, noise, and noise related hearing problems (2) Do patterns of hearing damage differ for different

  16. Comparing the Impact of Specific Strength Training vs General Fitness Training on Professional Symphony Orchestra Musicians

    DEFF Research Database (Denmark)

    Nygaard Andersen, Lotte; Mann, Stephanie; Juul-Kristensen, Birgit

    2017-01-01

    mass index, and self-assessed physical fitness. A total of 23 professional symphony orchestra musicians were randomly allocated to either the SST (n=12) or GFT (n=11) groups. Participants conducted three 20-minutes exercise periods/wk at the workplace for 9 weeks. RESULTS: Evaluations of both...

  17. Reliability-aware iterative detection scheme (RAID) for distributed IDM space-time codes in relay systems

    Science.gov (United States)

    Lenkeit, Florian; Wübben, Dirk; Dekorsy, Armin

    2013-12-01

    In this article, distributed interleave-division multiplexing space-time codes (dIDM-STCs) are applied for multi-user two-hop decode-and-forward (DF) relay networks. In case of decoding errors at the relays which propagate to the destination, severe performance degradations can occur as the original detection scheme for common IDM-STCs does not take any reliability information about the first hop into account. Here, a novel reliability-aware iterative detection scheme (RAID) for dIDM-STCs is proposed. This new detection scheme takes the decoding reliability of the relays for each user into account for the detection at the destination. Performance evaluations show that the proposed RAID scheme clearly outperforms the original detection scheme and that in certain scenarios even a better performance than for adaptive relaying schemes can be achieved.

  18. Design and evaluation of an IDM-based MIMO FSO system over Gamma-Gamma turbulence channels

    Science.gov (United States)

    Zhang, Chenglei; Zhou, Xiaolin; Zheng, Xiaowei; Du, Jianhong

    2011-12-01

    In this paper, we design an interleave-division-multiplexing (IDM) based multiple-input multiple-output (MIMO) free-space optics (FSO) communication system. The system overcomes problems harassing conventional optical MIMO systems such as restrictions of antenna number and high complexity in receiver. An iterative on-off keying (OOK) modulated IDM MIMO detection algorithm is developed. Expression of an upper bound of frame-error-rate (FER) is derived. In addition, we evaluate the BER performance of the proposed optical MIMO scheme in various FSO scenarios. Simulations confirm that the proposed scheme can effectively increase the feasibility of FSO communications over Gamma-Gamma turbulence-induced fading channels.

  19. Durability of glasses from the Hg-doped Integrated DWPF Melter System (IDMS) campaign

    International Nuclear Information System (INIS)

    Jantzen, C.M.

    1992-01-01

    The Integrated DWPF Melter System (IDMS) for the vitrification of high-level radioactive wastes is designed and constructed to be a 1/9th scale prototype of the full scale Defense Waste Processing Facility (DWPF) melter. The IDMS facility is the first engineering scale melter system capable of processing mercury, and flowsheet levels of halides and noble metals. In order to determine the effects of mercury on the feed preparation process, the off-gas chemistry, glass melting behavior, and glass durability, a three-run mercury (Hg) campaign was conducted. The glasses produced during the Hg campaign were composed of Batch 1 sludge, simulated precipitate hydrolysis aqueous product (PHA) from the Precipitate Hydrolysis Experimental Facility (PHEF), and Frit 202. The glasses were produced using the DWPF process/product models for glass durability, viscosity, and liquidus. The durability model indicated that the glasses would all be more durable than the glass qualified in the DWPF Environmental Assessment (EA). The glass quality was verified by performing the Product Consistency Test (PCT) which was designed for glass durability testing in the DWPF

  20. Universitat Bielefeld, Institut fur Didaktik der Mathematik, Schriftenreihe des IDM, 1/1974. (University of Bielefeld, Institute for the Teaching of Mathematics, Series of Publications of the IDM, 1/1974.)

    Science.gov (United States)

    Bauersfeld, H., Ed.; And Others

    This document contains papers discussing the status of aspects of mathematics education. A brief description of the establishment and operation of the Institute for the Teaching of Mathematics (IDM) is presented first. The lengthier second paper discusses the reconciliation of main aspects of mathematics teaching. The remaining five papers…

  1. Universitat Bielefeld, Institut fur Didaktik der Mathematik, Schriftenreihe des IDM, 2/1974. (University of Bielefeld, Institute for the Teaching of Mathematics, Series of Publications of the IDM, 2/1974.)

    Science.gov (United States)

    Bauersfeld, H., Ed.; And Others

    This document contains papers prepared for two meetings involving the French educational research in mathematics institute (IREM) and the German institute (IDM) at the University of Bielefeld. The 14 papers concern: (1) the organization of the school systems in the Federal Republic of Germany and in France; (2) mathematics curricula in German…

  2. Symbols of Hyphenated Identity Drawing Maps (IDM) for Arab and Jewish Students at the University of Haifa

    Science.gov (United States)

    Hertz-Lazarowitz, Rachel; Farah, Abeer; Zelniker, Tamar

    2013-01-01

    In 2008, we conducted a large scale study following our methodology developed for the analysis of drawings to assess identity (Hertz-Lazarowitz, Farah & Yosef-Meitav, 2012). We gathered interviews and asked for Identity Drawing Maps (IDM) from 184 students aged from 20-30 years. The symbols in the drawings were grouped in five categories:…

  3. The theory of reference values: an unfinished symphony.

    Science.gov (United States)

    Siest, Gerard; Henny, Joseph; Gräsbeck, Ralph; Wilding, Peter; Petitclerc, Claude; Queraltó, Josep M; Hyltoft Petersen, Peter

    2013-01-01

    The history of the theory of reference values can be written as an unfinished symphony. The first movement, allegro con fuoco, played from 1960 to 1980: a mix of themes devoted to the study of biological variability (intra-, inter-individual, short- and long-term), preanalytical conditions, standardization of analytical methods, quality control, statistical tools for deriving reference limits, all of them complex variations developed on a central melody: the new concept of reference values that would replace the notion of normality whose definition was unclear. Additional contributions (multivariate reference values, use of reference limits from broad sets of patient data, drug interferences) conclude the movement on the variability of laboratory tests. The second movement, adagio, from 1980 to 2000, slowly develops and implements initial works. International and national recommendations were published by the IFCC-LM (International Federation of Clinical Chemistry and Laboratory Medicine) and scientific societies [French (SFBC), Spanish (SEQC), Scandinavian societies…]. Reference values are now topics of many textbooks and of several congresses, workshops, and round tables that are organized all over the world. Nowadays, reference values are part of current practice in all clinical laboratories, but not without difficulties, particularly for some laboratories to produce their own reference values and the unsuitability of the concept with respect to new technologies such as HPLC, GCMS, and PCR assays. Clinicians through consensus groups and practice guidelines have introduced their own tools, the decision limits, likelihood ratios and Reference Change Value (RCV), creating confusion among laboratorians and clinicians in substituting reference values and decision limits in laboratory reports. The rapid development of personalized medicine will eventually call for the use of individual reference values. The beginning of the second millennium is played allegro ma non

  4. Induction therapy with vincristine, adriamycin, dexamethasone (VAD) and intermediate-dose melphalan (IDM) followed by autologous or allogeneic stem cell transplantation in newly diagnosed multiple myeloma.

    Science.gov (United States)

    Lokhorst, H M; Sonneveld, P; Cornelissen, J J; Joosten, P; van Marwijk Kooy, M; Meinema, J; Nieuwenhuis, H K; van Oers, M H; Richel, D J; Segeren, C N; Veth, G; Verdonck, L F; Wijermans, P W

    1999-02-01

    We performed a phase II study to test the efficacy and feasibility of induction therapy with vincristine, adriamycin and dexamethasone (VAD) and intermediate-dose melphalan, 70 mg/m2 (IDM), to autologous or allogeneic stem cell transplantation in newly diagnosed multiple myeloma (MM). A total of 77 patients received two cycles of VAD (n = 62) and/or two cycles of i.v. IDM 70 mg/m2 (n = 15) combined with G-CSF. PBSC were harvested after the first IDM, successfully in 87% of patients. Patients with a response to induction received myeloablative therapy with PBSCT (n = 50) followed by IFN maintenance or allo-BMT (n = 11). Seventy-two per cent of patients achieved a response after VAD which increased to 85% after IDM. Of patients who received PBSCT and allo-BMT, 24% and 45% achieved CR, respectively. Toxicity of induction consisted mainly of bone marrow suppression after IDM (median 8 days) with prolonged aplasia in 11% of patients after the second IDM. Only six infections WHO grade 3 occurred during induction. Treatment-related mortality of PBSCT and allo-BMT was 6% and 18%, respectively. Median time of follow-up is 44 months, and 50% of patients after PBSCT and 60% of patients after allo-BMT are still in remission. Survival rates of all patients were 82%, 75% and 63%, and for transplanted patients 86%, 79% and 68% after 12, 24 and 36 months. Well known prognostic factors, including alpha-IFN maintenance after PBSCT, were not significant for response or survival although patients in CR after allo-BMT had a strong tendency for better outcome. VAD/IDM is an effective and safe induction therapy for autologous and allogeneic stem cell transplantation. Based on these observations a phase III trial was started in October 1995 comparing IFN maintenance with PBSCT and allo-BMT after response to induction with VAD and IDM.

  5. Rapid and sensitive controlled release monitoring method of biomedical combined products with IDM for pain management and cancer treatment.

    Science.gov (United States)

    Liu, Hsia-Wei; Huang, Ching-Cheng

    2014-01-01

    New designed combined products and its determination for pain management and cancer treatment were studied. A rapid and sensitive stability indicating HPLC method had been developed and validated for the determination of Indomethacin(IDM) in a transdermal patch. This analytical method was successfully applied to the determination of Indomethacin in a transdermal patch and can be used for routine quality control analysis. Chromatographic separation was achieved isocratically on an Inertsil® C8-3 column utilizing a mobile phase of acetonitrile / 0.01 M monobasic sodium phosphate and 0.01 M dibasic sodium phosphate buffer (pH 3) (65:35, v/v) at the flow rate of 1 mL/min with UV detection at the wavelength of 210 nm. The system suitability was performed, and the result showed that Indomethacin(IDM) and its impurity were separated. The calibration curve of Indomethacin(IDM) was linear in the range of 0.1~15 ppm (r = 0.9989, n = 3).

  6. Optimization of cardiac troponin I pull-down by IDM affinity beads and SELDI.

    Science.gov (United States)

    Bovenkamp, Diane E; Stanley, Brian A; Van Eyk, Jennifer E

    2007-01-01

    Cardiac troponin I (cTnI) is a key regulator of cardiac muscle contraction. Upon myocardial cell injury, cTnI is lost from the cardiac myocyte and can be detected in serum, in some cases with specific disease-induced modifications, making it an important diagnostic marker for acute myocardial injury. Presently, hospital laboratories use enzyme-linked immunosorbent assays to detect cTnI, but this type of analysis lacks information about modified forms of protein (degradation or phosphorylation) that may give a more specific diagnosis from either serum or biopsies. Because cardiac and serum tissues are widely used for proteomic analysis, it is important to detect these cTnI posttranslational modifications. Therefore, we have chosen to optimize the enrichment and detection of cTnI protein by IDM Affinity Bead pull-down and surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS or SELDI) analyses. By adjusting the chemical compositions of the buffers, we have retained antibody specificity and enriched for different forms of cTnI and its associated proteins.

  7. Expression Surpassing Words: Gorecki’s Symphony No. 3, Op. 36 “Sorrowful Songs”

    Directory of Open Access Journals (Sweden)

    Alyssa K. Griffith

    2015-12-01

    Full Text Available The experience of listening to Gorecki’s Symphony no. 3, op. 36 “Sorrowful Songs” is one that is not easily forgotten. It is not only musically captivating, but also historically fascinating. After its premiere in 1977, Gorecki’s piece captivated listeners across the globe as it became a cultural phenomenon in both Europe and America. The music was a stunning success in both the Classical and popular cultures. What is it about the music that is so captivating? How did the trending, popular thoughts compare to Gorecki’s original ideas and compositional motives? What actually inspired this piece? By looking at the composition and premise of each movement, I am going to introduce how the piece was written around the theme of maternal love and separation of mother and child. The Third Symphony was heavily influenced by Gorecki’s personal past, but also by his Catholic beliefs and by Polish history. The separate texts to this three movement piece deal individually with a mother’s lament over her son’s departure, the Virgin Mary’s grief at her Son’s death, and finally the words of an incarcerated prison girl to her mother. Because of the setting from which the third text was drawn, and because of Gorecki’s Polish history and experiences in the post-holocaust world, many people have interpreted this to be a “war piece” which avenges the sufferers of the Holocaust. According to Gorecki, this piece is a lament- it expresses a profound sense of grief which, arguably, cannot accurately be expressed with words. Gorecki used his music to confront, mourn, and express his pain and the pain of many other people. By finding primary sources, such as interviews of Henryk Gorecki, and by looking at the scholarly books and journals by Luke B. Howard, Adrian Thomas, and other scholars of Polish avant-garde music, I hope to properly understand and express the intentions Gorecki wished to convey by writing The Symphony of Sorrowful Songs.

  8. Schmidt. Sinfonie Nr. 1 E-Dur; Strauss. Vier sinfonische Zwischenspiele aus Intermezzo. Detroit Symphony Orchestra, Neeme Järvi / Helge Grünewald

    Index Scriptorium Estoniae

    Grünewald, Helge

    1996-01-01

    Uuest heliplaadist "Schmidt. Sinfonie Nr. 1 E-Dur; Strauss. Vier sinfonische Zwischenspiele aus Intermezzo. Detroit Symphony Orchestra, Neeme Järvi. Chandos/Koch CD 9357 (WD: 68'20") DDD (WD:114'36")

  9. Sibelius: Pohjola's Daughter; Night Ride and Sunrise; Four Legends from Kalevala (Lemminkäinen Suite). Gothenburg Symphony Orchestra, Neeme Järvi / Brian Hunt

    Index Scriptorium Estoniae

    Hunt, Brian

    1997-01-01

    Uuest heliplaadist "Sibelius: Pohjola's Daughter; Night Ride and Sunrise; Four Legends from Kalevala (Lemminkäinen Suite). Gothenburg Symphony Orchestra / Neeme Järvi. Deutsche Grammophon 453 426-2; 70:37 DDD

  10. Communist anniversaries as a symphony of power and science (case study of Bulgaria

    Directory of Open Access Journals (Sweden)

    Ewelina Drzewiecka

    2017-12-01

    Full Text Available The aim of the paper is to show the interplay between the power and the science in the context of cultural memory. The focus is on the Cyrillo-Methodian anniversaries in Bulgaria in the communist period, and the object of the analysis is the anniversary of 1969. The context relates to the process of development of new historiography and the functionalization of the nation-centric narrative. The main issue discussed is how the Communist Party, as a political institution, and the Bulgarian Academy of Science, as an academic institution, cooperated to establish a new vision of society. The discussion offers an interpretation in the light of the Orthodox concept of the symphony of power perceived as a metaphor of the relation between the secular and the spiritual power.

  11. Transfinite harmonization by taking the dissonance out of the quantum field symphony

    International Nuclear Information System (INIS)

    El Naschie, M.S.

    2008-01-01

    Particle physics may be likened to a magnificent symphony. Alas due to some instrumental defects, wrong reading of the notes and a lack of virtuosity of some members of the orchestra, a non-negligible number of dissonants are making it sound less than perfect. By means of the specific example of renormalization groups applied to GUT unification, the present work aims at illustrating the point we just made and showing how a simplictic transfinite adjustment of our formulas lead to harmonization and consequently considerable simplification of well known theories which goes as far as facilitating the discovery of new connections and the solution of many problems which were previously thought very hard, if at all possible, to solve

  12. Large size dry (LSD) spike isotope dilution mass spectrometry (IDMS) for input accounting of U and Pu in fuel reprocessing : a field experience

    International Nuclear Information System (INIS)

    Gurba, P.B.; Rajendra Kumar; Singh, R.K.; Bajpai, D.D.; Udagatti, S.V.; Xavier, C.A.; Kesarkar, M.A.

    1999-01-01

    State of the art analytical measurement instruments are used for nuclear material accounting. In the ever continuing process of strengthening the safeguards and related mechanism, the onus has now shifted towards improving the agreement between the nuclear material measurements performed by facility lab. and SAL, IAEA. A first step has been taken in this direction by SAL, IAEA in suggesting use of common (for facility and reference lab.) LSD mixed (U,Pu) spike for IDMS determination of U, Pu in input KMP tanks of spent fuel reprocessing plants. An exercise was carried out to field test the feasibility of LSD-IDMS procedure

  13. A STUDY OF THE IMAGE OF TULIP SYMPHONY - A DEFINING INGREDIENT IN THE DEVELOPMENT OF THE URBAN BRAND OF PITESTI

    Directory of Open Access Journals (Sweden)

    Mihaela, ASANDEI

    2014-11-01

    Full Text Available The city is a fundamental element of the identity of contemporary society, fulfilling in each urban community complex functions that depend on the needs, interests and aspirations of the people and of the political and economic system. The urban identity of Pitesti is defined by a set of features with certain significance for each inhabitant of the city. The Tulip Symphony is a symbol that has been created, developed and promoted during the past four decades by the urban community. The present study aims to study how residents of Pitesti perceive the urban product named the Tulip Symphony is and present the conclusions of a statistical survey conducted during the 37th edition of the event.

  14. The Iterative Decision Method (IDM): Academy of Health Sciences Reports, Small Group Decision-Making and Problem-Solving Bibliography, and Statistical References.

    Science.gov (United States)

    1983-03-01

    475. IDM Bibliography 11 * 89. James , J. A preliminary study of the size determinant in small group . interaction. American Sociological Review, 1951...Social Psydology, 1969, 12, 144-150. 109. Laughlin, P. R., & Jaccard , J. J. Social facilitation and observational learning of individuals and

  15. Induction therapy with vincristine, adriamycin, dexamethasone (VAD) and intermediate-dose melphalan (IDM) followed by autologous or allogeneic stem cell transplantation in newly diagnosed multiple myeloma

    NARCIS (Netherlands)

    Lokhorst, H. M.; Sonneveld, P.; Cornelissen, J. J.; Joosten, P.; van Marwijk Kooy, M.; Meinema, J.; Nieuwenhuis, H. K.; van Oers, M. H.; Richel, D. J.; Segeren, C. N.; Veth, G.; Verdonck, L. F.; Wijermans, P. W.

    1999-01-01

    We performed a phase II study to test the efficacy and feasibility of induction therapy with vincristine, adriamycin and dexamethasone (VAD) and intermediate-dose melphalan, 70 mg/m2 (IDM), to autologous or allogeneic stem cell transplantation in newly diagnosed multiple myeloma (MM). A total of 77

  16. Intermediate-dose melphalan (IDM) combined with G-CSF (filgrastim) is an effective and safe induction therapy for autologous stem cell transplantation in multiple myeloma

    NARCIS (Netherlands)

    Lokhorst, H. M.; Sonneveld, P.; Wijermans, P. W.; van Marwijk Kooy, M.; Meuwissen, O. J.; van Oers, R. H.; van der Griend, R.; Dekker, A. W.

    1996-01-01

    Twenty-one previously untreated multiple myeloma (MM) patients and 10 previously treated patients with refractory or relapsed disease received two or three cycles of intermediate-dose melphalan (70 mg/m2) (IDM), administered intravenously every 6 weeks. Seven previously untreated patients received

  17. Spiritual and ceremonial plants in North America: an assessment of Moerman's ethnobotanical database comparing Residual, Binomial, Bayesian and Imprecise Dirichlet Model (IDM) analysis.

    Science.gov (United States)

    Turi, Christina E; Murch, Susan J

    2013-07-09

    Ethnobotanical research and the study of plants used for rituals, ceremonies and to connect with the spirit world have led to the discovery of many novel psychoactive compounds such as nicotine, caffeine, and cocaine. In North America, spiritual and ceremonial uses of plants are well documented and can be accessed online via the University of Michigan's Native American Ethnobotany Database. The objective of the study was to compare Residual, Bayesian, Binomial and Imprecise Dirichlet Model (IDM) analyses of ritual, ceremonial and spiritual plants in Moerman's ethnobotanical database and to identify genera that may be good candidates for the discovery of novel psychoactive compounds. The database was queried with the following format "Family Name AND Ceremonial OR Spiritual" for 263 North American botanical families. Spiritual and ceremonial flora consisted of 86 families with 517 species belonging to 292 genera. Spiritual taxa were then grouped further into ceremonial medicines and items categories. Residual, Bayesian, Binomial and IDM analysis were performed to identify over and under-utilized families. The 4 statistical approaches were in good agreement when identifying under-utilized families but large families (>393 species) were underemphasized by Binomial, Bayesian and IDM approaches for over-utilization. Residual, Binomial, and IDM analysis identified similar families as over-utilized in the medium (92-392 species) and small (Binomial analysis when separated into small, medium and large families. The Bayesian, Binomial and IDM approaches identified different genera as potentially important. Species belonging to the genus Artemisia and Ligusticum were most consistently identified and may be valuable in future studies of the ethnopharmacology. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  18. Intermediate-dose melphalan (IDM) combined with G-CSF (filgrastim) is an effective and safe induction therapy for autologous stem cell transplantation in multiple myeloma.

    Science.gov (United States)

    Lokhorst, H M; Sonneveld, P; Wijermans, P W; van Marwijk Kooy, M; Meuwissen, O J; van Oers, R H; van der Griend, R; Dekker, A W

    1996-01-01

    Twenty-one previously untreated multiple myeloma (MM) patients and 10 previously treated patients with refractory or relapsed disease received two or three cycles of intermediate-dose melphalan (70 mg/m2) (IDM), administered intravenously every 6 weeks. Seven previously untreated patients received three and all other patients received two courses of IDM. The objective of the study was to reduce the toxicity of high-dose melphalan (140 mg/m2) (HDM) while maintaining its cytotoxic efficacy and secondly to ensure the possibility of collecting sufficient numbers of peripheral blood stem cells (PBSC) for transplantation. 18 (85%) previously untreated patients responded, of whom four achieved CR (18%). In addition five out of 10 previously treated patients with refractory or relapsed disease responded although bone marrow toxicity in this category was a major drawback. Toxicity was moderate, consisting of alopecia and moderate bone marrow suppression: the granulocyte count dropped below 0.5 x 10(9)/l and platelets below 25 x 10(9)/l for a median of 8 and 6 d, respectively. No serious infections occurred and the majority of patients attended the out-patient clinic. In 12/14 previously untreated patients sufficient peripheral blood CD34+ cells for harvest were present in the repopulation phase after the first IDM. In nine patients peripheral blood stem cells were collected and eight patients have undergone successful transplantation. Repeated IDM followed by filgrastim is highly effective in untreated MM and may be safely administered to reduce tumour load prior to PBSC collection. Autologous stem cells harvested after repeated IDM have a full long-term repopulating capacity.

  19. Investigation and experimental validation of the contribution of optical interconnects in the SYMPHONIE massively parallel computer

    International Nuclear Information System (INIS)

    Scheer, Patrick

    1998-01-01

    Progress in microelectronics lead to electronic circuits which are increasingly integrated, with an operating frequency and an inputs/outputs count larger than the ones supported by printed circuit board and back-plane technologies. As a result, distributed systems with several boards cannot fully exploit the performance of integrated circuits. In synchronous parallel computers, the situation is worsen since the overall system performances rely on the efficiency of electrical interconnects between the integrated circuits which include the processing elements (PE). The study of a real parallel computer named SYMPHONIE shows for instance that the system operating frequency is far smaller than the capabilities of the microelectronics technology used for the PE implementation. Optical interconnections may cancel these limitations by providing more efficient connections between the PE. Especially, free-space optical interconnections based on vertical-cavity surface-emitting lasers (VCSEL), micro-lens and PIN photodiodes are compatible with the required features of the PE communications. Zero bias modulation of VCSEL with CMOS-compatible digital signals is studied and experimentally demonstrated. A model of the propagation of truncated gaussian beams through micro-lenses is developed. It is then used to optimise the geometry of the detection areas. A dedicated mechanical system is also proposed and implemented for integrating free-space optical interconnects in a standard electronic environment, representative of the one of parallel computer systems. A specially designed demonstrator provides the experimental validation of the above physical concepts. (author) [fr

  20. Emotions, arousal, and frontal alpha rhythm asymmetry during Beethoven's 5th symphony.

    Science.gov (United States)

    Mikutta, Christian; Altorfer, Andreas; Strik, Werner; Koenig, Thomas

    2012-10-01

    Music is capable of inducing emotional arousal. While previous studies used brief musical excerpts to induce one specific emotion, the current study aimed to identify the physiological correlates of continuous changes in subjective emotional states while listening to a complete music piece. A total of 19 participants listened to the first movement of Ludwig van Beethoven's 5th symphony (duration: ~7.4 min), during which a continuous 76-channel EEG was recorded. In a second session, the subjects evaluated their emotional arousal during the listening. A fast fourier transform was performed and covariance maps of spectral power were computed in association with the subjective arousal ratings. Subjective arousal ratings had good inter-individual correlations. Covariance maps showed a right-frontal suppression of lower alpha-band activity during high arousal. The results indicate that music is a powerful arousal-modulating stimulus. The temporal dynamics of the piece are well suited for sequential analysis, and could be necessary in helping unfold the full emotional power of music.

  1. Einstein's unfinished symphony listening to the sounds of space-time

    CERN Document Server

    Bartusiak, Marcia

    2000-01-01

    A new generation of observatories, now being completed worldwide, will give astronomers not just a new window on the cosmos but a whole new sense with which to explore and experience the heavens above us. Instead of collecting light waves or radio waves, these novel instruments will allow astronomers to at last place their hands upon the fabric of space-time and feel the very rhythms of the universe. These vibrations in space-time-or gravity waves-are the last prediction of Einstein's general theory of relativity yet to be observed directly. They are his unfinished symphony, waiting nearly a century to be heard. When they finally reveal themselves to astronomers, we will for the first time be able to hear the cymbal crashes from exploding stars, tune in to the periodic drumbeats from swiftly rotating pulsars, listen to the extended chirps from the merger of two black holes, and eavesdrop on the remnant echoes from the mighty jolt of the Big Bang itself. When Einstein introduced general relativity in 1915, it ...

  2. Bohuslav Martinů’s Symphony No. 4 (1945). Evaluation of the Sources and Effects on Performance

    OpenAIRE

    Choa, Sharon

    2011-01-01

    As far as it is known, there are more extant sources for Martinů’s Fourth Symphony than any of his other symphonic works. Examining these sources reveals a series of changes Martinů made in his score since its first completion in June 1945. Even though the changes are not very substantial, they were sufficiently significant to alter an interpreter’s view of the orchestration of the work; in particular, the role of the piano within the orchestral texture. Collecting and examining the source...

  3. New age in Serbia, Zoran Simjanović: New ideas symphony

    Directory of Open Access Journals (Sweden)

    Radović Branka

    2007-01-01

    Full Text Available ′New age′ was a trend which appeared in the music of the 1980’s, bringing a new dimension to art music in general, especially in its reception. At first its development was stimulated by technological inventions, ′the technological craze′, by new carriers of sound, simultaneously globalizing art and making it widely accessible. This new trend includes quite disparate categories. It does not distance itself from subculture, and in art music it gravitates towards cosmopolitism while being permeated with other musical trends such as pop, rock, jazz and other phenomena of show business and popular art. This trend was originally found in the large number of occult writing which flooded book markets all over the world, to which Umberto Eco gave an important base (Foucault's Pendulum and others. In his essay on the music of the eighties, Peter Niklas Wilson, one of the most significant theoreticians of this movement, researches into all elements of those novelties, not hesitating to call this art eclectic, commercial and the like. Examples of Serbian music get into such style directives. The New Ideas Symphony by film score composer Zoran Simjanović, was performed in the open air at Kalemegdan fortress in 2006, before an audience of about one thousand people. Since then the recording has often been broadcast on television and radio channels. In its combination of folklore and film models, traces of rock, pop, and jazz can also be found, in a score with all symphonic characteristics. This attempt is a fascinating item for research as well as a pleasure to be listened to.

  4. Ergonomic activity analysis of the musicians of the Symphony Orchestra of Paraná state: risk factors and workloads

    Directory of Open Access Journals (Sweden)

    Jaqueline de Lima

    2014-04-01

    Full Text Available This study aimed to investigate the risk factors present in the work activity and their impact on the health of the musicians of the Symphony Orchestra of Parana state. It is a descriptive qualitative research based on the method of Ergonomic Workplace Analysis of Francophone strand, used as a tool by occupational therapists in the health-work interface. The following procedures were performed: bibliographical survey, documental analysis of productivity data, production and quality of the task, systematic observation of the rehearsals of the Symphony Orchestra of Parana, task and workplace analysis with the application of Ergonomic Workplace Analysis (EWA and, confrontation of the data analyzed with an instrumental musician. As a result, the study showed significant deviations with reference to the standards described in Brazilian Norm 17 (Ergonomics, especially regarding individual cognitive and physical demands as well as demands related to work organization, considering each item evaluated by this analytical instrument. The action of occupational therapy was grounded on the insertion in the health and illness process, health promotion, illness prevention, and training of musicians as workers and social actors, envisioning the transformation of work situations.

  5. Mining CRRES IDM Pulse Data and CRRES Environmental Data to Improve Spacecraft Charging/Discharging Models and Guidelines

    Science.gov (United States)

    Brautigam, D. H.; Frederickson, A. R.

    2004-01-01

    One can truly predict the charging and pulsing in space over a year's time using only the physics that worked for periods of an hour and less in prior publications. All portions of the task were achieved, including the optional portion of determining a value for conductivity that best .t the data. Fortran statements were developed that are required for the NUMIT runs to work with this kind of data from space. In addition to developing the Fortran for NUMIT, simple correlations between the IDM pulsing history and the space radiation were observed because we now have a better characterization of the space radiation. The study showed that: (1) the new methods for measurement of charge storage and conduction in insulators provide the correct values to use for prediction of charging and pulsing in space; (2) the methods in NUMIT that worked well for time durations less than hours now work well for durations of months; (3) an average spectrum such as AE8 is probably not a good guide for predicting pulsing in space one must take time dependence into account in order to understand insulator pulsing; and (4) the old method for predicting pulse rates in space that was based on the CRRES data could be improved to include dependencies on material parameters.

  6. Prevalence and consequences of musculoskeletal symptoms in symphony orchestra musicians vary by gender: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Paarup Helene M

    2011-10-01

    Full Text Available Abstract Background Musculoskeletal symptoms are common in the neck, back, and upper limbs amongst musicians. Playing-related musculoskeletal disorders have been found to range from 32% to 87% with a tendency for female musicians to have more problems than males. Studies of musculoskeletal problems in instrumentalists have generally involved pre-professional musicians or populations comprising musicians of different levels. The objective of this study was therefore to investigate the prevalence, duration and consequences of musculoskeletal symptoms in professional symphony orchestra musicians. Methods A cross-sectional questionnaire study. The study population comprised of 441 musicians from six Danish symphony orchestras; 342 (78% completed the questionnaire. Results During the last year 97% of the women and 83% of the men experienced symptoms in at least one of nine anatomic regions (neck, upper and lower back, shoulders, elbows, and hands and wrists. 86% of the women and 67% of the men experienced symptoms for more than seven days, while 63% of the women and 49% of the men had symptoms for more than 30 days. Woodwind players had a lower risk for musculoskeletal symptoms and a lower risk for the consequences. Among consequences were changed way of playing, reported by 73% of the musicians, difficulty in daily activities at home, reported by 55%, and difficulty in sleeping, reported by 49%. Their health behaviour included taking paracetamol as the most used analgesic, while physiotherapists and general practitioners were reported as the most consulted health care professionals concerning musculoskeletal problems. Results regarding symptoms in six anatomic regions were compared to results for a sample of the general Danish workforce. Symptoms were more frequent in musicians and lasted longer than in the general workforce. This applied to both genders. Conclusions Within the last year most symphony orchestra musicians experienced musculoskeletal

  7. [AN OVERALL SOUND PROCESS] Altered Dynamics and Instrumentation at the Onset of Recapitulation in the Nineteenth-Century Symphony

    Directory of Open Access Journals (Sweden)

    Steven Craig Cannon

    2016-01-01

    Full Text Available In standard sonata form, the onset of recapitulation exactly quotes the beginning of the exposition, preserving both “structural” parameters (melody, rhythm, harmony, key, as well as “secondary” ones (dynamics, instrumentation, register, tempo. In practice, however, composers may alter any aspect of the main theme upon its return. Most analysis of such recapitulatory alteration has focused on structural change, with other parameters receiving relatively little attention. This paper examines composers’ handling of two secondary parameters—dynamic markings and instrumental density—at the beginnings of recapitulations in the nineteenth-century symphonic repertoire. In order to analyse a large number of works, a system of classifications for recapitulatory alterations is necessary. The alterations fall into four broad types: “similar” recapitulations have few or no changes to dynamics and instrumentation, “intensified” recapitulations are louder or more fully orchestrated than the beginning of the exposition, “attenuated” recapitulations have quieter dynamics or sparser orchestration, and “contradictory” recapitulations have alterations to dynamics and instrumentation that work in opposite directions. After explaining this classification system in detail, with examples from specific symphonies, the paper then gives the results of an analytical survey of 483 sonata-form movements from 282 symphonies dating from the years 1800 to 1899. Similar and intensified recapitulations are most common, with preferences changing over time. Until about the 1840s, similar recapitulations were most common, but from around the 1860s on, intensified returns became the default choice. Attenuated and contradictory recapitulations, by contrast, are very rare throughout the century.

  8. The effect of exercise on the absorption of inhaled human insulin via the AERx(R) iDMS in people with type 1 diabetes

    DEFF Research Database (Denmark)

    Petersen, Astrid Heide; Kohler, G; Korsatko, S

    2007-01-01

    OBJECTIVE - This study investigated the effect of moderate exercise on the absorption of inhaled insulin via the AERx(R) insulin Diabetes Management System (iDMS). RESEARCH DESIGN AND METHODS - In this randomized, open-label, 4-period cross-over, glucose clamp study 23 non-smoking subjects...... with type 1 diabetes received a dose of 0.19 units/kg inhaled human insulin followed in random order by either 1) no exercise (NOEX), or 30 min exercise starting 2) 30 min after dosing (EX30), 3) 120 min after dosing (EX120), or 4) 240 min after dosing (EX240). RESULTS - Exercise changed the shape...... of the free plasma insulin curves, but compared to NOEX the AUC(ins) for the first 2 hours after start of exercise was unchanged for EX30 and EX240, while 15% decreased for EX120 (p

  9. IDM-PhyChm-Ens: intelligent decision-making ensemble methodology for classification of human breast cancer using physicochemical properties of amino acids.

    Science.gov (United States)

    Ali, Safdar; Majid, Abdul; Khan, Asifullah

    2014-04-01

    Development of an accurate and reliable intelligent decision-making method for the construction of cancer diagnosis system is one of the fast growing research areas of health sciences. Such decision-making system can provide adequate information for cancer diagnosis and drug discovery. Descriptors derived from physicochemical properties of protein sequences are very useful for classifying cancerous proteins. Recently, several interesting research studies have been reported on breast cancer classification. To this end, we propose the exploitation of the physicochemical properties of amino acids in protein primary sequences such as hydrophobicity (Hd) and hydrophilicity (Hb) for breast cancer classification. Hd and Hb properties of amino acids, in recent literature, are reported to be quite effective in characterizing the constituent amino acids and are used to study protein foldings, interactions, structures, and sequence-order effects. Especially, using these physicochemical properties, we observed that proline, serine, tyrosine, cysteine, arginine, and asparagine amino acids offer high discrimination between cancerous and healthy proteins. In addition, unlike traditional ensemble classification approaches, the proposed 'IDM-PhyChm-Ens' method was developed by combining the decision spaces of a specific classifier trained on different feature spaces. The different feature spaces used were amino acid composition, split amino acid composition, and pseudo amino acid composition. Consequently, we have exploited different feature spaces using Hd and Hb properties of amino acids to develop an accurate method for classification of cancerous protein sequences. We developed ensemble classifiers using diverse learning algorithms such as random forest (RF), support vector machines (SVM), and K-nearest neighbor (KNN) trained on different feature spaces. We observed that ensemble-RF, in case of cancer classification, performed better than ensemble-SVM and ensemble-KNN. Our

  10. Theme-period, as the basic compositional form during the first movement of Isak Shehu`s Symphony “Illyrians”

    Directory of Open Access Journals (Sweden)

    Fatos Lumani

    2017-03-01

    Full Text Available The traditional doctrine of musical forms has its sentence, phrase, period and punctuation. Questions, exclamations, subordinate clauses are everywhere, voices rise and fall, and, in all of this, the gesture of music is borrowed from the speaking voice” (Adorno, Gillespie, 1993. Based on the quote of Adorno (1993, we will analyze this paper with the purpose of answering a few questions concerning the already designated thesis “The theme – Period, a fundamental compositional form in the first movement of the symphony by Cesk Zadeja”, talking through the period from different perspectives as follows: The complex sentence and the period in music; The initial forms of the period in music; The period in classicism/the period and the folk melodies in the classical symphonies; Theme-period, as the basic compositional form during the first movement of Isak Shehu`s Symphony. As an introduction we would like to refer to some studies/lectures that relate to language with music, such as: “The Unanswered Question: Six Talks at Harvard”(Bernstein, 1981 where Bernstein in his opening fi rst lecture clarified the significance of “the interdisciplinary strategy by saying that “...the best way to ‘know’ a thing is in the context of another discipline”. Within these six lectures, Bernstein explains his ideas regarding the universality of music drawing analogies to other disciplines such as linguistics, philosophy, aesthetics, acoustics and history of music. As the primary interdisciplinary subject, Bernstein chose the recent work of Noam Chomsky on linguistic theories about “Language and Mind”. In the first three lectures, Bernstein analyzes the music from a linguistic aspect: phonology (sound, syntax (structure and semantics (meaning, pinpointing the music of the classical period.

  11. Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1996-01-01

    Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi. 1 CD Deutsche Grammophon 447 760-2GH (72 minutes: DDD)

  12. The effects of isotope-labeled analogs on the LC-IDMS measurement by comparison of ESI responses and matrix effect of melamine,13C3-melamine,13C3+15N3-melamine, and15N3-melamine.

    Science.gov (United States)

    Li, Xiu Qin; Zhang, Qing He; Yang, Zong; Li, Hong Mei; Huang, Dong Feng

    2017-05-01

    In this paper, the effect of isotope-labeled analogs on the liquid chromatography-isotope dilution mass spectrometry (LC-IDMS) measurement was evaluated based on the comparison research of electrospray ionization responses (ESI) and matrix effect of melamine, 13 C 3 -melamine, 13 C 3 + 15 N 3 -melamine, and 15 N 3 -melamine. The isotope-labeled melamines had similar ionization efficiency with melamine in the electrospray ionization source, but the intensity of corresponding quantitative fragment ions had distinctive differences. Based on the density functional theory at the B3LYP/6-311+G** level, this phenomenon was explained very well. The rare cleavage pathways of melamine, which just could be exactly identified by 15 N-labeled melamines, resulted in the difference of quantitative fragment ions between 15 N-labeled melamines and melamine. The interaction of ESI response between melamine and isotope-labeled melamines was investigated using MRM monitor mode. 15 N-labeled melamine had significant ion inter-suppression effect on melamine, while 13 C-labeled melamine had little influence on melamine. Finally, the influence of different isotope-labeled melamines on the LC-IDMS result was evaluated using the IDMS correction factor (θ). Taking the determination of melamine in milk powder as an example, the matrix effects of different isotope-labeled melamines and melamine had notable difference and the impact of this difference on the measurement results depended on the concentrations of analyte and matrix solution. It was worth noting that 15 N 3 -melamine exhibited significant ion suppression to melamine in matrix solution. The deviation of the results from IDMS method might reach 59% using 15 N 3 -melamine as internal standard in special matrix solution. Graphical Abstract The comparison of ESI responses of melamine, 13 C 3 -melamine, 13 C 3 + 15 N 3 -melamine and 15 N 3 -melamine.

  13. Discrepancies between the use of MDRD-4 IDMS and CKD-EPI equations, instead of the Cockcroft-Gault equation, in the determination of the dosage of direct oral anticoagulants in patients with non-valvular atrial fibrillation.

    Science.gov (United States)

    Pérez Cabeza, Alejandro Isidoro; Chinchurreta Capote, Pedro Antonio; González Correa, Jose Antonio; Ruiz Mateas, Francisco; Rosas Cervantes, Gabriel; Rivas Ruiz, Francisco; Valle Alberca, Almudena; Bravo Marqués, Rafael

    2018-02-09

    Direct oral anticoagulants (DOACs) require dose adjustment according to estimated clearance creatinine (eClCr) using the Cockcroft-Gault (CG) equation. There are discrepancies with the equations that estimate glomerular filtration rate (eGFR). We analyse how the use of the CKD-EPI and MDRD-4 IDMS equations affect the recommended dosage for ACODs. Retrospective study of patients with non-valvular atrial fibrillation seen at a cardiology clinic between November 2012 and August 2014. Patients were reclassified according to the recommended dosage for dabigatran, rivaroxaban, apixaban and edoxaban, based on the eGFR equation used. Other clinical factors are taken into account, according to the product label. We analysed the percentage of discordance. Four hundred and fifty-four patients, 53.3% men, with a mean age of 68.7±13.8 years were studied. The mean intra-individual differences recorded for the CG equation were 3.9ml/min/1.73m 2 with MDRD-4 IDMS (95% CI 1.4-6.4, P=.003) and 11.3ml/min/1.73m 2 with CKD-EPI (95% CI 8.9-13.7, P<.001). A gradient is observed in the discordance of the posology (apixaban 1.1%, dabigatran 3.5%, edoxaban 5.7%, rivaroxaban 8.4% with MDRD-4 IDMS). Differences were limited to patients with eClCr<60ml/min and were more evident in≥75 years in which the eGFR equations overestimate renal function. In patients with non-valvular atrial fibrillation, especially with renal failure and in the elderly, eGFR equations tend to overestimate renal function relative to CG and therefore suggest an overdose of DOACs. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  14. Induction of immune responses and clinical efficacy in a phase II trial of IDM-2101, a 10-epitope cytotoxic T-lymphocyte vaccine, in metastatic non-small-cell lung cancer.

    Science.gov (United States)

    Barve, Minal; Bender, James; Senzer, Neil; Cunningham, Casey; Greco, F Anthony; McCune, David; Steis, Ronald; Khong, Hung; Richards, Donald; Stephenson, Joe; Ganesa, Prasanthi; Nemunaitis, Jackie; Ishioka, Glenn; Pappen, Beena; Nemunaitis, Michael; Morse, Michael; Mills, Bonnie; Maples, Phillip B; Sherman, Jeffrey; Nemunaitis, John J

    2008-09-20

    Generation of broad cytotoxic T-lymphocyte responses against multiple epitopes and tumor-associated antigens (TAAs) may provide effective immunotherapy in patients with cancer. We evaluated a single-vial peptide vaccine consisting of nine HLA-A2 supertype-binding epitopes (two native and seven analog epitopes modified for optimal HLA binding or T-cell receptor stimulation) covering five TAAs and the universal helper pan-DR epitope, formulated as a stable emulsion with incomplete Freund's adjuvant (Montanide ISA 51; Seppic SA, Paris, France). The clinical efficacy, safety, and multiepitope immunogenicity of IDM-2101 was evaluated in patients with stage IIIB or IV non-small-cell lung cancer (NSCLC). A total of 63 patients were enrolled who were positive for HLA-A2. End points included survival, safety, and immune response. IDM-2101 (previously EP-2101) was administered every 3 weeks for the first 15 weeks, then every 2 months through year 1, then quarterly through year 2, for a total of 13 doses. Epitope-specific cytotoxic and helper T-lymphocyte immunogenic responses were measured by the interferon gamma enzyme-linked immunosorbent spot assay. No significant adverse events were noted. Low-grade erythema and pain at the injection site were the most common adverse effects. One-year survival in the treated patients was 60%, and median survival was 17.3 months. One complete and one partial response were identified. Survival was longer in patients demonstrating an immune response to epitope peptides (P IDM-2101 was well tolerated, and evidence of efficacy was suggested.

  15. SpoonEMF, une brique logicielle pour l'utilisation de l'IDM dans le cadre de la réingénierie de programmes Java5

    OpenAIRE

    Barais , Olivier

    2006-01-01

    2 ième Journée sur l'Ingénièrie Dirigée par les Modèles; Ce document présente succinctement SpoonEMF, une brique logicielle pour l'utilisation de l'IDM dans le cadre de la réingénierie d'applications écrites en Java. L'accent dans cette courte présentation est mis sur les cas d'utilisation possibles de cette brique logicielle et l'intérêt des choix techniques retenus : le framework EMF pour l'expression du méta-modèle afin de favoriser l'interopérabilité avec d'autres outils et l'intégration ...

  16. Prevalence of decreased glomerular filtration rate in patients seeking non-nephrological medical care--an evaluation using IDMS-traceable creatinine based MDRD as well as Mayo Clinic quadratic equation estimates.

    Science.gov (United States)

    Risch, Lorenz; Saely, Christoph H; Neyer, Ulrich; Hoefle, Guenter; Gouya, Ghazaleh; Zerlauth, Manfred; Risch, Gerhard M; Risch, Martin; Drexel, Heinz

    2007-03-01

    Data on the prevalence of decreased glomerular filtration rate in Europe are limited. Most of the available studies did not employ laboratory methods providing creatinine concentrations traceable to the reference method, i.e. isotope dilution mass spectrometry (IDMS). We therefore conducted a cross-sectional study in the principality of Liechtenstein consecutively enrolling adult patients seeking non-nephrological medical care from whom serum samples were referred for renal function assessment. All measurements were done in one central laboratory. The estimated glomerular filtration rate (eGFR) was calculated based on the determination of IDMS-traceable creatinine by a kinetic Jaffe method (Roche Diagnostics, Switzerland) by means of the MDRD and Mayo Clinic quadratic equations. We further estimated the incidence of end stage renal disease during the next 5 years. For 43% (n=9378) of the entire population>or=25 years renal function assessment was available. An eGFR indicating chronic kidney disease (CKD) stages 3-5 was found in 4.93% when using the MDRD equation and in 3.98 % when using the Mayo Clinic quadratic equation. The two equations had a very good agreement in classifying patients to have an eGFR consistent with CKD stages 3-5 (Cohen's kappa 0.887). Further calculations suggested that among patients aged 80 or younger, annually 42 per 100,000 are going to develop an eGFR<15 ml/min/1.73 m2 over the next 5 years. 4-5% of patients seeking non-nephrological medical advice have an eGFR consistent with CKD stages 3-5, and a considerable number of subjects is expected to develop end stage renal disease over a 5 year period. In order to obtain comparable kidney function estimates among different institutions it is not only important to use standardized methods to measure creatinine but rather to employ standardized methods to calculate a GFR estimate.

  17. There is also a story in Lutosławski: Narrative archetypes in the first movement of Witold Lutosławski's second symphony

    Directory of Open Access Journals (Sweden)

    Zatkalik Miloš

    2016-01-01

    Full Text Available Narrativity in music is seldom connected to the compositions based on aleatoric procedures and the use of sound masses. Yet, it can be demonstrated that the first movement of Witold Lutosławski's Second Symphony projects a meaningful set of relations which is later called into question and reconfigured, thus meeting at least some of the conditions for narratological approach. The attention is focused on the tone pitch parameter and in that sense it can be noticed that the movement is founded on the alternation of twelve-note aggregate and symmetrical, all-combinatorial hexachord 012678. This description suggests invariance, the lack of directed movement, since both tonal arrays are characterised by a high level of entropy. In spite of this, there is a clear effort to achieve a directed movement, as a result of the procedures used to organise tonal pitches, and, especially, as a result of the treatment of hexachords. The paper will investigate how the flow of events in this movement can be related to the system of mythos - the archetypal narrative categories - as were first defined by the Canadian literary critic Northrop Frye, and adjusted for musical narrative by Byron Almén. The system is based on the intersection of the two fundamental opposites: defeat/victory and order/disorder, resulting in four categories: comedy, romance, irony/satire and tragedy. No matter how paradoxical it may seem, it is the abovementioned entropy that can be considered as the initial order, and its disorder is achieved by attempts to establish directed movement. The ambivalence of archetypal categories and their interweaving is not uncommon in the narrative process. Therefore, the possibility of various interpretations of narrative trajectory will be discussed.

  18. Audiograms of symphony orchestra musicians

    DEFF Research Database (Denmark)

    Obeling, Lise; Poulsen, Torben

    1998-01-01

    performed during rehearsal and during concerts in the four orchestras with a sound level meter placed in various instrument groups. At the same time a noise dose meter was used to evaluate the dose perceived by specific orchestra members.The average audiogram showed a decrease at higher frequencies similar......, which takes account of the number of years at work, the number of playing hours per week, and the average sound level in the orchestra for the instrument group. In almost all cases the measured audiograms looked better than the predictions from ISO 1999.It may be concluded from this investigation...

  19. Hadronic octaves: Symphony in treble clef

    International Nuclear Information System (INIS)

    Ne'eman, Yuval

    2002-01-01

    Pythagoreanism, as derived from the physics of music, an artificial quantized system, involved simple ratios between integers and was conjectured by the Pythagoreans to extend to the whole of physics (the Music of the Spheres). It hit the jackpot in 1895 with Balmer's formula and has dominated XXth Century physics, with its Quantum Foundations. I review the history of Hadron Spectroscopy and my personal role in 1958-1964, i.e. (1) my 1960 discovery of SU(3) symmetry with an octet assignment for the j = (1/2) baryons (independently reached somewhat later by M. Gell-Mann), and (2) in 1961 (with H. Goldberg) my mathematical construction of a structural model which was then developed into the physical quark model by Gell-Mann and Zweig

  20. The gravitational wave symphony of the Universe

    Indian Academy of Sciences (India)

    phase transitions in the early Universe, quantum fluctuations resulting in a characteristic background in the early Universe. ... laser interferometric gravitational wave (GW) detectors. These detectors will take data .... In Einstein's theory gravitational waves have two independent polarizations. The effect on a circular ring of ...

  1. A Symphony of Redistributive Instruments Instruments

    NARCIS (Netherlands)

    F.T. Zoutman (Floris)

    2014-01-01

    markdownabstract__Abstract__ One of the most important trends in developed countries is the rise of economic inequality. In the US the top 1 percent currently earns a little more than 22 percent of all income.1 In the period 1993-2012 real income of the top income earners has increased by 86

  2. The gravitational wave symphony of the Universe

    Indian Academy of Sciences (India)

    predictions of general relativity that have so far eluded all efforts. We will begin by discussing the ... tially sensitive to the intensity of radiation and build up the signal-to-noise ratio (SNR) by incoherent superposition of ..... Future detectors may give us clues on the equation of state of dense nuclear matter of gravitationally ...

  3. Spacetime Symphony: APOD and Gravitational Waves

    Science.gov (United States)

    Cominsky, Lynn R.; Simonnet, Aurore; LIGO-Virgo Scientific Collaboration

    2017-01-01

    In 1915, Albert Einstein published his General Theory of Relativity. In this theory, gravity is not a force, but a property of space and time in the presence of massive objects. A century later, on September 14, 2015, the Laser Interferometer Gravitational-wave Observatory (LIGO) received the first confirmed gravitational wave signals. Now known as GW150914, the event represents the coalescence of two distant black holes that were previously in mutual orbit. The LIGO-Virgo Scientific Collaboration planned a detailed social media strategy to publicize the February 11, 2016 press conference that announced this discovery. Astronomy Picture of the Day (APOD) was a major factor in disseminating the now iconic imagery that was developed, and the LVC worked closely with APOD to ensure that the secrecy would be maintained throughout the press embargo period. Due to the success of our efforts, we repeated the process for the AAS press conference that announced GW151226, the second confirmed gravitational wave event. We have also repurposed the APOD imagery for an online course for community college instructors, as well as in a poster that will be available through CPEPphysics.org (Contemporary Physics Education Project).

  4. Sound Exposure of Symphony Orchestra Musicians

    DEFF Research Database (Denmark)

    Schmidt, Jesper Hvass; Pedersen, Ellen Raben; Juhl, Peter Møller

    2011-01-01

    Background: Assessment of sound exposure by noise dosimetry can be challenging especially when measuring the exposure of classical orchestra musicians where sound originate from many different instruments. A new measurement method of bilateral sound exposure of classical musicians was developed a...

  5. Hadronic Octaves: Symphony in Treble Clef

    Science.gov (United States)

    Ne'eman, Yuval

    2002-06-01

    Pythagoreanism, as derived from the physics of music, an artificial quantized system, involved simple ratios between integers and was conjectured by the Pythagoreans to extend to the whole of physics (the Music of the Spheres). It hit the jackpot in 1895 with Balmer's formula and has dominated XXth Century physics, with its Quantum Foundations. I review the history of Hadron Spectroscopy and my personal role in 1958-1964, i.e. (1) my 1960 discovery of SU(3) symmetry with an octet assignment for the j = 1/2 baryons (independently reached somewhat later by M. Gell-Mann), and (2) in 1961 (with H. Goldberg) my mathematical construction of a structural model which was then developed into the physical quark model by Gell-Mann and Zweig.

  6. Hormone symphony during root growth and development.

    Science.gov (United States)

    Garay-Arroyo, Adriana; De La Paz Sánchez, María; García-Ponce, Berenice; Azpeitia, Eugenio; Alvarez-Buylla, Elena R

    2012-12-01

    Hormones regulate plant growth and development in response to external environmental stimuli via complex signal transduction pathways, which in turn form complex networks of interaction. Several classes of hormones have been reported, and their activity depends on their biosynthesis, transport, conjugation, accumulation in the vacuole, and degradation. However, the activity of a given hormone is also dependent on its interaction with other hormones. Indeed, there is a complex crosstalk between hormones that regulates their biosynthesis, transport, and/or signaling functionality, although some hormones have overlapping or opposite functions. The plant root is a particularly useful system in which to study the complex role of plant hormones in the plastic control of plant development. Physiological, cellular, and molecular genetic approaches have been used to study the role of plant hormones in root meristem homeostasis. In this review, we discuss recent findings on the synthesis, signaling, transport of hormones and role during root development and examine the role of hormone crosstalk in maintaining homeostasis in the apical root meristem. Copyright © 2012 Wiley Periodicals, Inc.

  7. Microscale quantitative analysis of polyhydroxybutyrate in prokaryotes using IDMS

    NARCIS (Netherlands)

    Velasco Alvarez, M.I.; ten Pierick, A.; van Dam, P.T.N.; Maleki Seifar, R.; van Loosdrecht, Mark C.M.; Wahl, S.A.

    2017-01-01

    Poly(3-hydroxybutyrate) (PHB) is an interesting biopolymer for replacing petroleum-based plastics, its biological production is performed in natural and engineered microorganisms. Current metabolic engineering approaches rely on high-throughput strain construction and screening. Analytical

  8. The black hole symphony: probing new physics using gravitational waves.

    Science.gov (United States)

    Gair, Jonathan R

    2008-12-13

    The next decade will very likely see the birth of a new field of astronomy as we become able to directly detect gravitational waves (GWs) for the first time. The existence of GWs is one of the key predictions of Einstein's theory of general relativity, but they have eluded direct detection for the last century. This will change thanks to a new generation of laser interferometers that are already in operation or which are planned for the near future. GW observations will allow us to probe some of the most exotic and energetic events in the Universe, the mergers of black holes. We will obtain information about the systems to a precision unprecedented in astronomy, and this will revolutionize our understanding of compact astrophysical systems. Moreover, if any of the assumptions of relativity theory are incorrect, this will lead to subtle, but potentially detectable, differences in the emitted GWs. Our observations will thus provide very precise verifications of the theory in an as yet untested regime. In this paper, I will discuss what GW observations could tell us about known and (potentially) unknown physics.

  9. A Symphony for Your Brain: A Psychological Research Methods Case

    Science.gov (United States)

    Hager, Lisa D.

    2004-01-01

    This article presents a case study where students examine an advertisement claiming that listening to classical music in an advertised CD set will enhance their cognitive skills and creativity. Students evaluate the claims and evidence cited to support them and then determine how they might independently verify the claims. The author states that…

  10. El departamento musical Disney : las Silly Symphonies y Carl Stalling

    OpenAIRE

    Duarte del Moral, Marina

    2014-01-01

    La historia de la animación tiene un nombre propio: Walt Disney. Gracias a su experimentación en diversos campos de esta materia, Disney consigue desarrollar la animación y su universo de una forma perseverante y continua, adaptándose a los diversos cambios producidos desde el nacimiento de ésta, reinventando una y otra vez el sector y añadiendo su toque mágico a la personalidad de cada personaje y cada obra. En este camino no está solo gracias al trabajo de genios como Carl Stalling, que apo...

  11. Distortion product otoacoustic emission fine structure of symphony orchestra musicians

    DEFF Research Database (Denmark)

    Reuter, Karen; Hammershøi, Dorte

    2006-01-01

    Otoacoustic emissions (OAE) are sounds produced by the healthy inner ear. They can be measured as low-level signals in the ear canal and are used to monitor the functioning of outer hair cells. Many studies indicate that OAE might be a more sensitive measure to detect early noise-induced haring...... losses than pure-tone audiometry. The distortion product otoacoustic emission (DPOAE) fine structure is obtained when the ear is stiumulated by dual tone stimuli using a high frequency resolution. It is characterized by quasi-periodic variations across frequency, as it can be observed in the hearing...

  12. A symphony of inner ear developmental control genes

    Directory of Open Access Journals (Sweden)

    Kraus Petra

    2010-07-01

    Full Text Available Abstract The inner ear is one of the most complex and detailed organs in the vertebrate body and provides us with the priceless ability to hear and perceive linear and angular acceleration (hence maintain balance. The development and morphogenesis of the inner ear from an ectodermal thickening into distinct auditory and vestibular components depends upon precise temporally and spatially coordinated gene expression patterns and well orchestrated signaling cascades within the otic vesicle and upon cellular movements and interactions with surrounding tissues. Gene loss of function analysis in mice has identified homeobox genes along with other transcription and secreted factors as crucial regulators of inner ear morphogenesis and development. While otic induction seems dependent upon fibroblast growth factors, morphogenesis of the otic vesicle into the distinct vestibular and auditory components appears to be clearly dependent upon the activities of a number of homeobox transcription factors. The Pax2 paired-homeobox gene is crucial for the specification of the ventral otic vesicle derived auditory structures and the Dlx5 and Dlx6 homeobox genes play a major role in specification of the dorsally derived vestibular structures. Some Micro RNAs have also been recently identified which play a crucial role in the inner ear formation.

  13. Searching for the full symphony of black hole binary mergers

    Science.gov (United States)

    Harry, Ian; Bustillo, Juan Calderón; Nitz, Alex

    2018-01-01

    Current searches for the gravitational-wave signature of compact binary mergers rely on matched-filtering data from interferometric observatories with sets of modeled gravitational waveforms. These searches currently use model waveforms that do not include the higher-order mode content of the gravitational-wave signal. Higher-order modes are important for many compact binary mergers and their omission reduces the sensitivity to such sources. In this work we explore the sensitivity loss incurred from omitting higher-order modes. We present a new method for searching for compact binary mergers using waveforms that include higher-order mode effects, and evaluate the sensitivity increase that using our new method would allow. We find that, when evaluating sensitivity at a constant rate-of-false alarm, and when including the fact that signal-consistency tests can reject some signals that include higher-order mode content, we observe a sensitivity increase of up to a factor of 2 in volume for high mass ratio, high total-mass systems. For systems with equal mass, or with total mass ˜50 M⊙, we see more modest sensitivity increases, applicable in searches for generic compact binaries.

  14. Reflections on Measuring Thinking, while Listening to Mozart's "Jupiter" Symphony.

    Science.gov (United States)

    Wasserman, Selma

    1989-01-01

    Reflects on educators' current preoccupation with assessment of higher order thinking skills. Easy-to-mark, forced-choice, pencil-and-paper tests with single numerical scores may trivialize the wonderful complexity of human capabilities. Includes 17 references. (MLH)

  15. Women Conductors: A Study of an Italian Major Symphony Orchestra

    African Journals Online (AJOL)

    The assumption was that not being used to be directed by a woman would affect their opinion on the individual's ability and on all women conductors, i.e. if few women are invited to be guest conductors, it must mean that there are few women conductors who are good enough. A survey of 58 musicians interviewed using ...

  16. Analysen zum Unterrichtshandeln - Band 5, IDM-Reihe, Untersuchungen zum Mathematikunterricht. (Analysis of Instructional Actions - Volume 5, IDM Series, Inquiries into Mathematics Instruction.)

    Science.gov (United States)

    Bauersfeld, Heinrich; And Others

    This set of five papers, written in German with abstracts in English, was collected by the Institut fuer Didaktit der Mathematik (Institute for the Teaching of Mathematics) at the University of Bielefeld in West Germany. In the first paper, Bauersfeld used a transcript of a videotaped scene of group work out of school as a basis for analyzing…

  17. Incorporating driver distraction in car-following models : Applying the TCI to the IDM

    NARCIS (Netherlands)

    Hoogendoorn, R.G.; van Arem, B.; Hoogendoorn, S.P.

    2013-01-01

    ITS can play a significant role in the improvement of traffic flow, traffic safety and greenhouse gas emissions. However, the implementation of Advanced Driver Assistance Systems may lead to adaptation effects in longitudinal driving behavior following driver distraction. It was however not yet

  18. Idm@ti Network: An Innovative Proposal for Improving Teaching and Learning in Spanish Universities

    Science.gov (United States)

    Salan, Nuria; Cabedo, Luis; Segarra, Mercedes; Guraya, Teresa; Lopez, Pascal; Sales, David; Gamez, Jose

    2017-01-01

    IdM@ti network members concurred in the diagnosis of the difficulties and opportunities arising from Bologna process implementation and teaching methodologies improvement in Materials Science and Engineering (MSE) teaching. This network has been created with the aim of improving efficiency of underway and future collaborations.The main objectives…

  19. Store and Forward: A Collaborative Approach for Developing Interactive Digital Media (IDM) for Classroom Instruction

    Science.gov (United States)

    Henke, Mitchell E.; Latendresse, Frank

    2005-01-01

    The availability of digital media technology for consumer use has increased students' exposure to technology that was once limited primarily to educational and business environments. As students become more adept consumers and developers of digital media, their expectations in the classroom increasingly involve digital media as an instructional…

  20. Maak het Verschil met Je Merk : Het Identiteitsmanagementdashboard (IDM) voor Zorggroep Sint Maarten

    NARCIS (Netherlands)

    Bouten, L.M. (Lisanne); Morel, K.P.N. (Kaj)

    2012-01-01

    Om medewerkers en cliënten van Zorggroep Sint Maarten (ZSM) te helpen bijdragen aan goede zorg en deel je leven, wil ZSM inzichtelijk maken hoe goed zij presteert op beide aspecten. Het lectoraat Identiteitsmarketing heeft hiertoe een identiteitsmanagementdashboard voor ZSM ontwikkeld dat niet

  1. IDM Supervision: An Integrated Developmental Model for Supervising Counselors and Therapists.

    Science.gov (United States)

    Stoltenberg, Cal D.; McNeill, Brian; Delworth, Ursula

    Understanding change over time in one's ability to function as a professional is fundamental in the practice of clinical supervision. Drawing on developmental models of human behavior, a model of the development over time of therapy practice is presented. Specific domains of clinical practice and overriding structures that provide markers in…

  2. Design, development and assessment of control schemes for IDMS in a standardized RTCP-based solution

    NARCIS (Netherlands)

    Montagud, M.; Boronat, F.; Stokking, H.M.; Cesar, P.

    2014-01-01

    Currently, several media sharing applications that allow social interactions between distributed users are gaining momentum. In these networked scenarios, synchronized playout between the involved participants must be provided to enable truly interactive and coherent shared media experiences. This

  3. Design, Development and Assessment of Control Schemes for IDMS in a Standardized RTCP-based Solution

    NARCIS (Netherlands)

    M.A. Montagud Climent (Mario); F. Boronat (Fernando); H.M. Stokking (Hans); P.S. Cesar Garcia (Pablo Santiago)

    2014-01-01

    htmlabstractCurrently, several media sharing applications that allow social interactions between distributed users are gaining momentum. In these networked scenarios, synchronized playout between the involved participants must be provided to enable truly interactive and coherent shared media

  4. Design, Development and Evaluation of an Adaptive and Standardized RTCP-based IDMS Solution

    NARCIS (Netherlands)

    M.A. Montagud Climent (Mario)

    2015-01-01

    htmlabstractNowadays, we are witnessing a transition from physical togetherness towards networked togetherness around media content. Novel forms of shared media experiences are gaining momentum, allowing geographically distributed users to concurrently consume the same media content while socially

  5. The inaudible symphony : On the detection and source identification of atmospheric infrasound

    NARCIS (Netherlands)

    Evers, L.G.

    2008-01-01

    Sound becomes inaudible if it consists of frequencies lower than 20 Hz, i.e. the human hearing threshold, and is called infrasound. Low frequency acoustic signals were first discovered after the eruption of the Krakatoa (Indonesia) in 1883. Due to its low frequency content, this infrasound traveled

  6. A symphony of regulations centered on p63 to control development of ectoderm-derived structures.

    Science.gov (United States)

    Guerrini, Luisa; Costanzo, Antonio; Merlo, Giorgio R

    2011-01-01

    The p53-related transcription factor p63 is critically important for basic cellular functions during development of the ectoderm and derived structure and tissues, including skin, limb, palate, and hair. On the one side, p63 is required to sustain the proliferation of keratinocyte progenitors, while on the other side it is required for cell stratification, commitment to differentiate, cell adhesion, and epithelial-mesenchymal signaling. Molecules that are components or regulators of the p63 pathway(s) are rapidly being identified, and it comes with no surprise that alterations in the p63 pathway lead to congenital conditions in which the skin and other ectoderm-derived structures are affected. In this paper, we summarize the current knowledge of the molecular and cellular regulations centered on p63, derived from the comprehension of p63-linked human diseases and the corresponding animal models, as well as from cellular models and high-throughput molecular approaches. We point out common themes and features, that allow to speculate on the possible role of p63 downstream events and their potential exploitation in future attempts to correct the congenital defect in preclinical studies.

  7. MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine

    OpenAIRE

    Sen, Chandan K.

    2011-01-01

    The human genome encodes 1,048 microRNAs (miRNAs). These miRNAs regulate virtually all biological processes. Leaving ignominy on the significance miRNAs behind we are approaching a new era in tissue repair where an ever expanding orchestra of events that enable tissue repair and regeneration seems to be conducted by miRNAs as the maestro. microRNAs are emerging as molecular rheostats that fine-tune and switch regulatory circuits governing tissue repair. Key elements of tissue repair such as s...

  8. MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine.

    Science.gov (United States)

    Sen, Chandan K

    2011-05-01

    The human genome encodes 1,048 microRNAs (miRNAs). These miRNAs regulate virtually all biological processes. Leaving ignominy on the significance miRNAs behind we are approaching a new era in tissue repair where an ever expanding orchestra of events that enable tissue repair and regeneration seems to be conducted by miRNAs as the maestro. microRNAs are emerging as molecular rheostats that fine-tune and switch regulatory circuits governing tissue repair. Key elements of tissue repair such as stem cell biology, inflammation, hypoxia-response, and angiogenesis are all under the sophisticated control of a network of specific mRNAs. Embryonic stem cells lacking miRNAs lose their "stemness." Manipulation of specific cellular miRNAs helps enhance reprogramming of somatic cells to an embryonic stem cell-like phenotype helping generate inducible pluripotent stem cells. Expression of miRNAs is subject to control by epigenetic factors. Such control influences the balance between proliferation and differentiation of stem cells. Angiomirs regulate various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells. MiRNAs play a key role in resolution of inflammation. Hypoxia-inducible mRNAs or hypoxamirs suppress mitochondrial respiration, cause cell cycle arrest, and interfere with growth factor signaling. miRNA-210 is a good example in this category that impairs wound closure. As fine tools enabling specific and temporally controlled manipulation of cell-specific miRNAs emerge, miRNA-based therapies hold promise in facilitating tissue repair. Treatment of skin wounds has lower barriers because it lends itself to local delivery of miRNA mimics and antagonizing agents minimizing risks associated with systemic off-target toxicity.

  9. Molecular symphony of tooth–jawbone morphogenesis and related disorders. Part 1: Morphogenesis

    Czech Academy of Sciences Publication Activity Database

    Matalová, Eva; Fleischmannová, Jana; Krejčí, P.; Míšek, Ivan

    2009-01-01

    Roč. 18, č. 4 (2009), 15-21 ISSN 1210-4272 R&D Projects: GA ČR GC524/08/J032 Institutional research plan: CEZ:AV0Z50450515 Keywords : odontogenesis * osteogenesis * dental disorders Subject RIV: FF - HEENT, Dentistry

  10. Smorgasbord or symphony? Assessing public health nutrition policies across 30 European countries using a novel framework.

    Science.gov (United States)

    Lloyd-Williams, Ffion; Bromley, Helen; Orton, Lois; Hawkes, Corinna; Taylor-Robinson, David; O'Flaherty, Martin; McGill, Rory; Anwar, Elspeth; Hyseni, Lirije; Moonan, May; Rayner, Mike; Capewell, Simon

    2014-11-21

    Countries across Europe have introduced a wide variety of policies to improve nutrition. However, the sheer diversity of interventions represents a potentially bewildering smorgasbord. We aimed to map existing public health nutrition policies, and examine their perceived effectiveness, in order to inform future evidence-based diet strategies. We created a public health nutrition policy database for 30 European countries. National nutrition policies were classified and assigned using the marketing "4 Ps" approach Product (reformulation, elimination, new healthier products); Price (taxes, subsidies); Promotion (advertising, food labelling, health education) and Place (schools, workplaces, etc.). We interviewed 71 senior policy-makers, public health nutrition policy experts and academics from 14 of the 30 countries, eliciting their views on diverse current and possible nutrition strategies. Product Voluntary reformulation of foods is widespread but has variable and often modest impact. Twelve countries regulate maximum salt content in specific foods. Denmark, Austria, Iceland and Switzerland have effective trans fats bans. Price EU School Fruit Scheme subsidies are almost universal, but with variable implementation.Taxes are uncommon. However, Finland, France, Hungary and Latvia have implemented 'sugar taxes' on sugary foods and sugar-sweetened beverages. Finland, Hungary and Portugal also tax salty products. Promotion Dialogue, recommendations, nutrition guidelines, labelling, information and education campaigns are widespread. Restrictions on marketing to children are widespread but mostly voluntary. Place Interventions reducing the availability of unhealthy foods were most commonly found in schools and workplace canteens. Interviewees generally considered mandatory reformulation more effective than voluntary, and regulation and fiscal interventions much more effective than information strategies, but also politically more challenging. Public health nutrition policies in Europe appear diverse, dynamic, complex and bewildering. The "4 Ps" framework potentially offers a structured and comprehensive categorisation. Encouragingly, the majority of European countries are engaged in activities intended to increase consumption of healthy food and decrease the intake of "junk" food and sugary drinks. Leading countries include Finland, Norway, Iceland, Denmark, Hungary, Portugal and perhaps the UK. However, all countries fall short of optimal activities. More needs to be done across Europe to implement the most potentially powerful fiscal and regulatory nutrition policies.

  11. Decolonising Research and Teaching Methodologies: A "Ninth Moment" Symphony of Artist-Educator-Researcher Voices

    Science.gov (United States)

    Jones, Janice K.; Batorowicz, Beata; Ladislas Derr, Robert; Peters, Sarah

    2015-01-01

    In an era of globalisation, positivist research methodologies and voices are privileged and funded over those of qualitative researchers. This has led to narrowing beliefs about what constitutes knowledge, and about the ways in which knowledge is constructed and evaluated, impacting upon the conduct, funding and reporting of arts research, and…

  12. Resurrection Symphony: "El Sistema" as Ideology in Venezuela and Los Angeles

    Science.gov (United States)

    Fink, Robert

    2016-01-01

    The explosive growth of Venezuela's "El Sistema" is rewriting the agenda of musical education in the West. Many commentators from the world of classical music react to the spectacle of dedicated young colonial musicians playing European masterworks as a kind of "miracle," accepting "Sistema" founder José Antonio…

  13. Ascorbate oxidase is the potential conductor of a symphony of signaling pathways.

    Science.gov (United States)

    De Tullio, Mario C; Guether, Mike; Balestrini, Raffaella

    2013-03-01

    The functional role of ascorbate oxidase (AO; EC 1.10.3.3) has never been fully explained so far, due to the difficulties in understanding the presence of an enzyme specifically oxidizing ascorbate with no obvious advantage, and the apparent disadvantage of lowering plant stress resistance as a consequence of ascorbate consumption. Here we suggest a complete change of perspective, by proposing an essential role of AO as a modulator of both ascorbate and oxygen content, with relevant implications related to signaling. By affecting the overall redox state, AO is actually involved in redox regulation in the extracellular matrix. In addition, AO can contribute to creating a hypoxic microenvironment, especially relevant in the maintenance of meristem identity and the establishment of mutualistic plant-microbe interactions. We also hypothesize the possible involvement of AO in the activation of a signaling cascade analogous to the mechanism of prolyl hydroxylases/Hypoxia Inducible Factors in animals.

  14. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra

    Directory of Open Access Journals (Sweden)

    Xiao-Xi Guo

    2016-06-01

    Full Text Available Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR, receptor tyrosine kinases (RTKs, ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy.

  15. Symphony and cacophony in ion track etching: how to control etching results

    Czech Academy of Sciences Publication Activity Database

    Fink, Dietmar; Kiv, A.; Cruz, S. A.; Munoz, G. H.; Vacík, Jiří

    2012-01-01

    Roč. 167, č. 7 (2012), s. 527-540 ISSN 1042-0150 R&D Projects: GA AV ČR IAA200480702 Institutional support: RVO:61389005 Keywords : ion tracks * polymers * etching * diodes * resistances Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 0.502, year: 2012

  16. It's a bittersweet symphony: simultaneously mixed emotional responses to music with conflicting cues.

    Science.gov (United States)

    Larsen, Jeff T; Stastny, Bradley J

    2011-12-01

    Some evidence indicates that emotional reactions to music can be organized along a bipolar valence dimension ranging from pleasant states (e.g., happiness) to unpleasant states (e.g., sadness), but songs can contain some cues that elicit happiness (e.g., fast tempos) and others that elicit sadness (e.g., minor modes). Some models of emotion contend that valence is a basic building block of emotional experience, which implies that songs with conflicting cues cannot make people feel happy and sad at the same time. Other models contend that positivity and negativity are separable in experience, which implies that music with conflicting cues might elicit simultaneously mixed emotions of happiness and sadness. Hunter, Schellenberg, and Schimmack (2008) tested these possibilities by having subjects report their happiness and sadness after listening to music with conflicting cues (e.g., fast songs in minor modes) and consistent cues (e.g., fast songs in major modes). Results indicated that music with conflicting cues elicited mixed emotions, but it remains unclear whether subjects simultaneously felt happy and sad or merely vacillated between happiness and sadness. To examine these possibilities, we had subjects press one button whenever they felt happy and another button whenever they felt sad as they listened to songs with conflicting and consistent cues. Results revealed that subjects spent more time simultaneously pressing both buttons during songs with conflicting, as opposed to consistent, cues. These findings indicate that songs with conflicting cues can simultaneously elicit happiness and sadness and that positivity and negativity are separable in experience. (c) 2011 APA, all rights reserved.

  17. Molecular symphony of tooth - bone morphogenesis and related disorders, Part 2: Remodelling and defects

    Czech Academy of Sciences Publication Activity Database

    Krejčí, P.; Matalová, Eva; Fleischmannová, Jana; Míšek, Ivan

    2009-01-01

    Roč. 18, č. 5 (2009), 14-21 ISSN 1210-4272 R&D Projects: GA ČR GC524/08/J032 Institutional research plan: CEZ:AV0Z50450515 Keywords : odontogenesis * osteogenesis * dental disorders Subject RIV: FF - HEENT, Dentistry

  18. An Unfinished Symphony: 21st Century Teacher Education Using Knowledge Creating Heutagogies

    Science.gov (United States)

    Ashton, Jean; Newman, Linda

    2006-01-01

    Globalisation has changed the way most people live, work and study in the 21st century. Teachers and teacher educators, like other professionals, must embrace these changes to be effective in their jobs and one ongoing change is the use of Information Communication Technologies (ICTs) for lifelong learning. In this paper we describe how one group…

  19. Quorum-Sensing Kinetics in Saccharomyces cerevisiae: A Symphony of ARO Genes and Aromatic Alcohols.

    Science.gov (United States)

    Avbelj, Martina; Zupan, Jure; Kranjc, Luka; Raspor, Peter

    2015-09-30

    The kinetics of quorum sensing in Saccharomyces cerevisiae were studied using a mini-fermentation platform. The quorum-sensing molecules were monitored using our previous HPLC approach that is here supported by quantitative real-time PCR analysis of the quorum-sensing genes. We thus initially confirm correlations between peak production rates of the monitored quorum-sensing molecules 2-phenylethanol, tryptophol, and tyrosol and peak expression of the genes responsible for their synthesis: ARO8, ARO9, and ARO10. This confirms the accuracy of our previously implemented kinetic model, thus favoring its use in further studies in this field. We also show that the quorum-sensing kinetics are precisely dependent on the population growth phase and that tyrosol production is also regulated by cell concentration, which has not been reported previously. Additionally, we show that during wine fermentation, ethanol stress reduces the production of 2-phenylethanol, tryptophol, and tyrosol, which opens new challenges in the control of wine fermentation.

  20. The potamochemical symphony: new progress in the high-frequency acquisition of stream chemical data

    Science.gov (United States)

    Floury, Paul; Gaillardet, Jérôme; Gayer, Eric; Bouchez, Julien; Tallec, Gaëlle; Ansart, Patrick; Koch, Frédéric; Gorge, Caroline; Blanchouin, Arnaud; Roubaty, Jean-Louis

    2017-12-01

    Our understanding of hydrological and chemical processes at the catchment scale is limited by our capacity to record the full breadth of the information carried by river chemistry, both in terms of sampling frequency and precision. Here, we present a proof-of-concept study of a lab in the field called the River Lab (RL), based on the idea of permanently installing a suite of laboratory instruments in the field next to a river. Housed in a small shed, this set of instruments performs analyses at a frequency of one every 40 min for major dissolved species (Na+, K+, Mg2+, Ca2+, Cl-, SO42-, NO3-) through continuous sampling and filtration of the river water using automated ion chromatographs. The RL was deployed in the Orgeval Critical Zone Observatory, France for over a year of continuous analyses. Results show that the RL is able to capture long-term fine chemical variations with no drift and a precision significantly better than conventionally achieved in the laboratory (up to ±0.5 % for all major species for over a day and up to 1.7 % over 2 months). The RL is able to capture the abrupt changes in dissolved species concentrations during a typical 6-day rain event, as well as daily oscillations during a hydrological low-flow period of summer drought. Using the measured signals as a benchmark, we numerically assess the effects of a lower sampling frequency (typical of conventional field sampling campaigns) and of a lower precision (typically reached in the laboratory) on the hydrochemical signal. The high-resolution, high-precision measurements made possible by the RL open new perspectives for understanding critical zone hydro-bio-geochemical cycles. Finally, the RL also offers a solution for management agencies to monitor water quality in quasi-real time.

  1. No one can whistle a symphony: How hospitals design for daily cross-boundary collaboration

    DEFF Research Database (Denmark)

    Prætorius, Thim; Hasle, Peter; Nielsen, Anders Paarup

    2018-01-01

    Purpose: This research article investigates how and with which mechanisms health care professionals in practice design for collaboration to solve collective hospital tasks, which cross occupational and departmental boundaries. Design/methodology/approach: An in-depth multiple-case study of five....... Findings: Local collaboration across occupational and departmental boundaries requires bundles of behavioral formalization elements (e.g., standardized plans, resource allocation decisions, assigned formal roles, and handoff routines), and liaison devices (e.g., huddles, boards, and physical proximity...... and hospital managers can consider designing bundles of organizational design features to proactively develop and ensure collaboration capable of solving collective tasks and bridging departmental and occupational silos to improve health care delivery. Originality/value: This research article addresses...

  2. Music as Post-Traumatic Discourse: Nikolay Myaskovsky's Sixth Symphony

    Science.gov (United States)

    Zuk, Patrick

    2018-01-01

    This essay explores ways in which musicologists might extend work undertaken by humanities scholars in the interdisciplinary field of trauma studies that has highlighted the centrality of traumatic experience to modernist creativity. It is focussed around a case study of a musical composition that represents the emotional aftermath of a traumatic…

  3. Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony

    Science.gov (United States)

    2012-01-01

    Chronic obstructive pulmonary disease, metabolic syndrome and diabetes mellitus are common and underdiagnosed medical conditions. It was predicted that chronic obstructive pulmonary disease will be the third leading cause of death worldwide by 2020. The healthcare burden of this disease is even greater if we consider the significant impact of chronic obstructive pulmonary disease on the cardiovascular morbidity and mortality. Chronic obstructive pulmonary disease may be considered as a novel risk factor for new onset type 2 diabetes mellitus via multiple pathophysiological alterations such as: inflammation and oxidative stress, insulin resistance, weight gain and alterations in metabolism of adipokines. On the other hand, diabetes may act as an independent factor, negatively affecting pulmonary structure and function. Diabetes is associated with an increased risk of pulmonary infections, disease exacerbations and worsened COPD outcomes. On the top of that, coexistent OSA may increase the risk for type 2 DM in some individuals. The current scientific data necessitate a greater outlook on chronic obstructive pulmonary disease and chronic obstructive pulmonary disease may be viewed as a risk factor for the new onset type 2 diabetes mellitus. Conversely, both types of diabetes mellitus should be viewed as strong contributing factors for the development of obstructive lung disease. Such approach can potentially improve the outcomes and medical control for both conditions, and, thus, decrease the healthcare burden of these major medical problems. PMID:23101436

  4. Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators.

    Science.gov (United States)

    Dijk, Derk-Jan; von Schantz, Malcolm

    2005-08-01

    Daily rhythms in sleep and waking performance are generated by the interplay of multiple external and internal oscillators. These include the light-dark and social cycles, a circadian hypothalamic oscillator oscillating virtually independently of behavior, and a homeostatic oscillator driven primarily by sleep-wake behavior. Both internal oscillators contribute to variation in many aspects of sleep and wakefulness (e.g., sleep timing and duration, REM sleep, non-REM sleep, REM density, sleep spindles, slow-wave sleep, electroencephalographic oscillations during wakefulness and sleep, and performance parameters, including attention and memory). The relative contribution of the oscillators varies greatly between these variables. Sleep and performance cannot be predicted by either oscillator independently but critically depend on their phase relationship and amplitude. The homeostatic oscillator feeds back onto the central pacemaker or its outputs. Thus, the amplitude of observed circadian variation in sleep and performance depends on how long we have been asleep or awake. During entrainment to external 24-h cycles, the opposing interplay between circadian and homeostatic changes in sleep propensity consolidates sleep and wakefulness. Some physiological correlates and mediators of both the circadian process (e.g., melatonin and hypocretin rhythms) and the homeostat (e.g., EEG, slow-wave activity, and adenosine release) have been established, offering targets for the development of countermeasures for circadian sleep and performance disorders. Interindividual differences in sleep timing, duration, and morning or evening preference are associated with changes of circadian or sleep homeostatic processes or both. Molecular genetic correlates, including polymorphisms in clock genes, of some of these interindividual differences are emerging.

  5. From Assessment Cocktail to Assessment Symphony: The Development of Best Assessment Practices

    Directory of Open Access Journals (Sweden)

    Hanan M. Al-Kadri

    2015-12-01

    Despite the proven positive effects of formative compared to summative assessment on students׳ learning, most examinations in medical schools are still summative. Even assessment that is meant to be formative, is often used for summative decision making. The question therefore is: Are we reversing back to the psychometric era?

  6. Universitat Bielefeld, Institut fur Didaktik der Mathematik, Schriftenreihe des IDM, 5/1975. (University of Bielefeld, Institute for the Teaching of Mathematics, Series of Publications of the IDM, 5/1975).

    Science.gov (United States)

    Bauersfeld, H., Ed.; And Others

    This document contains seven papers (four written in English, the rest in German) concerning research on learning, curriculum, and instruction in mathematics education. Abstracts of all seven articles are provided both in English and in German. The four English-written papers discuss the following topics: (1) perspectives for modelling teaching…

  7. Lernen und Lehren von Mathematik-Analysen zum Unterrichtshandeln II - Band 6, IDM-Reihe, Untersuchungen zum Mathematikunterricht. (Learning and Teaching of Mathematics - Analysis of Instructional Actions II - Volume 6, IDM Series, Inquiries into Mathematics Instruction.)

    Science.gov (United States)

    Bauersfeld, Heinrich; And Others

    This set of five papers, written in German with abstracts in English, was collected by the Institut fuer Didaktit der Mathematik (Institute for the Teaching of Mathematics) at the University of Bielefeld in West Germany. In the first paper, Bauersfeld considers domains of subjective experiences as the best issue for an interactive theory of…

  8. Universitat Bielefeld, Institut fur Didaktik der Mathematik, Schriftenreihe des IDM, 3/1974. (University of Bielefeld, Institute for the Teaching of Mathematics, Series of Publications of the IDM, 3/1974.)

    Science.gov (United States)

    Bauersfeld, H., Ed.; And Others

    This document contains 13 papers presented at a conference concerned with the role of geometry in present day mathematics teaching. Of the six papers written in English, one looks at the Euclidean tradition in teaching mathematics, the algebraisation of geometry, and transformation geometry, and concludes with a discussion of twelve topics which…

  9. Universitat Bielefeld, Institut fur Didaktik der Mathematik, Schriftenreihe des IDM, 4/1975. (University of Bielefeld, Institute for the Teaching of Mathematics, Series of Publications of the IDM, 4/1975.)

    Science.gov (United States)

    Bauersfeld, H., Ed.; And Others

    This document contains seven papers (two written in English, the rest in German) on cognitive and non-cognitive variables in mathematics education. Abstracts of all seven articles are provided both in English and in German. The two English-written papers discuss individual differences that might influence the effectiveness of instruction in…

  10. Universitat Bielefeld, Institut fur Didaktik der Mathematik, Schriftenreihe des IDM, 6/1975. (University of Bielefeld, Institute for the Teaching of Mathematics, Series of Publications of the IDM, 6/1975.)

    Science.gov (United States)

    Bauersfeld, H., Ed.; And Others

    This document contains 15 papers concerned with mathematics teachers and teacher education. The introductory paper (in German) discusses trends and problems in mathematics teacher education curriculum reform. It is followed by 14 briefer responses from various participants in the conference on the topic; these are concerned with institutional…

  11. Low flux laboratory test of the Internal Discharge Monitor (IDM) experiment intended for CRRES. [Combined Release and Rediation Effects Satellite

    Science.gov (United States)

    Coakley, P. G.; Treadaway, M. J.; Robinson, P. A., Jr.

    1985-01-01

    Twelve planar printed circuit board samples and four cable samples were exposed to a distributed electron source of 150 keV to 2.5 MeV at 4.5 pA/sq cm and were monitored for electron-caused EMP. Discharges were recorded on 10 of the 16 samples during the first 18 hours of testing (total incident fluence equaled 1.8 x 10 to the 12th e/sq cm).

  12. Intervjuu American Wind Symphony Orchestra dirigendi Robert Austin Boudreau'ga = Interview with Mr. Robert Austin Boudreau, director of the American Wind Symphony Orchestra / Robert Austin Boudreau ; interv. Heli Ojamaa

    Index Scriptorium Estoniae

    Boudreau, Robert Austin

    2007-01-01

    11. IV 2007. a. tehtud telefoniintervjuu Robert A. Boudreau'ga, kellele arhitekt Louis I. Kahn disainis kontserdilaevad Point Counterpoint I (valmis 1961) ja Point Counterppoint II (kavandamist alustati 1966, valmis 1975). Louis I. Kahnist, koostööst arhitektiga ja laevadest. Selgitav kaaskiri arhitekt Heli Ojamaalt. Ill.: I laeva makett, II laeva joonised ja 4 värv. fotot

  13. TAHSĐN YÜCEL'S SHORT STORIES IN HIS BOOK 'MYSELF AND THE OTHER’ READING WITH THE 9th SYMPHONY OR THE CIRCUMSTANCES OF ÖTEGEÇE'S IN THE RHYTM OF 9th SYMPHONY

    Directory of Open Access Journals (Sweden)

    Ferhan AKGÜN (M.A.H.

    2009-01-01

    Full Text Available Literary works transforming in time have started toemerge in especially personal inclinations, psychologicalanalysis and universal matters; and have pushed thelimit lines lately. This limit was not only all about thecontent of the literature but also reflected towards theother fields of art. This intertextuality forms the roots ofhis short stories within “Me and the Others” by TahsinYücel, who is among the short story writers of 1950s.Tahsin Yücel expreses this in his words: “there exists arelation between the smallest and the greatest structures,between my structure and the others’. Reflecting theindividual and his inner world, departing from theindividual and giving messages to the society andhumankind, the writer endeavours to reach from localmatters to universal ones in his short stories within “Meand the Others”.

  14. Prevalence and consequences of musculoskeletal symptoms in symphony orchestra musicians vary by gender: a cross-sectional study

    DEFF Research Database (Denmark)

    Paarup, Helene M.; Baelum, Jesper; Holm, Jonas W

    2011-01-01

    ABSTRACT: BACKGROUND: Musculoskeletal symptoms are common in the neck, back, and upper limbs amongst musicians. Playing-related musculoskeletal disorders have been found to range from 32% to 87% with a tendency for female musicians to have more problems than males. Studies of musculoskeletal...... and a lower risk for the consequences. Among consequences were changed way of playing, reported by 73% of the musicians, difficulty in daily activities at home, reported by 55%, and difficulty in sleeping, reported by 49%. Their health behaviour included taking paracetamol as the most used analgesic, while...

  15. Symphonies of urban places : Urban rhythms as traces of time in space. A study of "urban rhythms" / Filipa Matos Wunderlich

    Index Scriptorium Estoniae

    Wunderlich, Filipa Matos

    2008-01-01

    Rütmi mõistest, linna rütmidest kui igapäevase elu ja ruumirütmide tervikust, kui uuest võimalusest analüüsida linnakeskkonda, kui täiendusest traditsiooniliste linnaprobleemide lahendamisele

  16. Voxel-based morphometry reveals increased gray matter density in Broca's area in male symphony orchestra musicians.

    Science.gov (United States)

    Sluming, Vanessa; Barrick, Thomas; Howard, Matthew; Cezayirli, Enis; Mayes, Andrew; Roberts, Neil

    2002-11-01

    Broca's area is a major neuroanatomical substrate for spoken language and various musically relevant abilities, including visuospatial and audiospatial localization. Sight reading is a musician-specific visuospatial analysis task, and spatial ability is known to be amenable to training effects. Musicians have been reported to perform significantly better than nonmusicians on spatial ability tests, which is supported by our findings with the Benton judgement of line orientation (JOL) test (P musicians. Voxel-based morphometry (VBM) and stereological analyses were applied to high-resolution 3D MR images in male orchestral musicians (n = 26) and sex, handedness, and IQ-matched nonmusicians (n = 26). The wide age range (26 to 66 years) of volunteers permitted a secondary analysis of age-related effects. VBM with small volume correction (SVC) revealed a significant (P = 0.002) region of increased gray matter in Broca's area in the left inferior frontal gyrus in musicians. We observed significant age-related volume reductions in cerebral hemispheres, dorsolateral prefrontal cortex subfields bilaterally and gray matter density in the left inferior frontal gyrus in controls but not musicians; a positive correlation between JOL test score and age in musicians but not controls; a positive correlation between years of playing and the volume of gray matter in a significant region identified by VBM in under-50-year-old musicians. We suggest that orchestral musical performance promotes use-dependent retention, and possibly expansion, of gray matter involving Broca's area and that this provides further support for shared neural substrates underpinning expressive output in music and language.

  17. A finely tuned symphony of factors modulates the microbial food web of a freshwater reservoir in spring

    Czech Academy of Sciences Publication Activity Database

    Šimek, Karel; Nedoma, Jiří; Znachor, Petr; Kasalický, Vojtěch; Jezbera, Jan; Horňák, Karel; Seďa, Jaromír

    2014-01-01

    Roč. 59, č. 5 (2014), s. 1477-1492 ISSN 0024-3590 R&D Projects: GA ČR(CZ) GA13-00243S Institutional support: RVO:60077344 Keywords : microbial food web * freshwater reservoir * limnology Subject RIV: EE - Microbiology, Virology Impact factor: 3.794, year: 2014

  18. Executive functions cannot be distinguished from general intelligence: Two variations on a single theme within a symphony of latent variance

    Directory of Open Access Journals (Sweden)

    Donald R Royall

    2014-10-01

    Full Text Available The empirical foundation of executive control function (ECF remains controversial. We have employed structural equation models (SEM to explicitly distinguish domain-specific variance in ECF performance from memory (MEM and shared cognitive performance variance, i.e., Spearman’s g. ECF does not survive adjustment for both MEM and g in a well fitting model of data obtained from non-demented older persons (N = 193. Instead, the variance in putative ECF measures is attributable only to g, and related to functional status only through a fraction of that construct (i.e., dECF. dECF is a homolog of the latent variable δ, which we have previously associated specifically with the Default Mode Network (DMN. These findings undermine the validity of ECF and its putative association with the frontal lobe. ECF may have no existence independent of general intelligence, and no functionally salient association with the frontal lobe outside of that structure’s contribution to the DMN.

  19. Long-term survival and quality of life in patients treated with a national all protocol 15-20 years earlier: IDM/HDM and late effects?

    Science.gov (United States)

    Moe, P J; Holen, A; Glomstein, A; Madsen, B; Hellebostad, M; Stokland, T; Wefring, K W; Steen-Johnsen, J; Nielsen, B; Howlid, H; Børsting, S; Hapnes, C

    1997-01-01

    In a follow-up matched control study the 93 (70.5%) survivors of 132 children treated with a national protocol for acute lymphoblastic leukemia (ALL) and 5 survivors of the other 21 cases of ALL in childhood diagnosed in the same period were evaluated. Thus it was also a population-based study. The national treatment protocol was used in the period 1975-1980. Methotrexate (MTX) infusions combined with intrathecal MTX were used as prophylaxis against neuroleukemia instead of irradiation. Neither doxorubicin (Adriamycin) nor cyclophosphamide was used in the protocol. A questionnaire covering demographic data, number of offspring, learning problems, level of athletic performance, education, and work status as well as medical information was used. Forms were received from 94 (96%) of the 98 adult surviving cases and corresponding controls in the family. Interviews were performed in the remaining four cases (4%). There were no statistical differences between the two groups with respect to physical and mental health and quality of life. Hospital records of all patients were also checked for possible late effects. There was no definite case of secondary malignant neoplasm; however, there was one case of prolactinoma and only one case of serious sequelae (hemiparesis during therapy), probably due to intrathecal and intravenous MTX.

  20. Ecological Modeling Guide for Ecosystem Restoration and Management

    Science.gov (United States)

    2012-08-01

    model. Then, identify a series of intermediate developmental models ( IDM ) that will be quantified sequentially until the final model has been...attack has been outlined, the next step is to begin quantifying and evaluating the series of IDMs (Grant and Swannack 2008). There is not a particular...order in which IDMs should be developed – in general, the first IDM should be trivially simple and subsequent IDMs should be increasingly complex

  1. Neural rhythmic symphony of human walking observation: Upside-down and Uncoordinated condition on cortical theta, alpha, beta and gamma oscillations.

    Science.gov (United States)

    Zarka, David; Cevallos, Carlos; Petieau, Mathieu; Hoellinger, Thomas; Dan, Bernard; Cheron, Guy

    2014-01-01

    Biological motion observation has been recognized to produce dynamic change in sensorimotor activation according to the observed kinematics. Physical plausibility of the spatial-kinematic relationship of human movement may play a major role in the top-down processing of human motion recognition. Here, we investigated the time course of scalp activation during observation of human gait in order to extract and use it on future integrated brain-computer interface using virtual reality (VR). We analyzed event related potentials (ERP), the event related spectral perturbation (ERSP) and the inter-trial coherence (ITC) from high-density EEG recording during video display onset (-200-600 ms) and the steady state visual evoked potentials (SSVEP) inside the video of human walking 3D-animation in three conditions: Normal; Upside-down (inverted images); and Uncoordinated (pseudo-randomly mixed images). We found that early visual evoked response P120 was decreased in Upside-down condition. The N170 and P300b amplitudes were decreased in Uncoordinated condition. In Upside-down and Uncoordinated conditions, we found decreased alpha power and theta phase-locking. As regards gamma oscillation, power was increased during the Upside-down animation and decreased during the Uncoordinated animation. An SSVEP-like response oscillating at about 10 Hz was also described showing that the oscillating pattern is enhanced 300 ms after the heel strike event only in the Normal but not in the Upside-down condition. Our results are consistent with most of previous point-light display studies, further supporting possible use of virtual reality for neurofeedback applications.

  2. Neural rhythmic symphony of human walking observation: Upside-down and Uncoordinated condition on cortical theta, alpha, beta and gamma oscillations.

    Directory of Open Access Journals (Sweden)

    David eZarka

    2014-09-01

    Full Text Available Biological motion observation has been recognized to produce dynamic change in sensorimotor activation according to the observed kinematics. Physical plausibility of the spatial-kinematic relationship of human movement may play a major role in the top-down processing of human motion recognition. Here, we investigated the time course of scalp activation during observation of human gait in order to extract and use it on future integrated brain-computer interface using virtual reality (VR. We analyzed event related potentials (ERP, the event related spectral perturbation (ERSP and the inter-trial coherence (ITC from high-density EEG recording during video display onset (-200 to 600 ms and the steady state visual evoked potentials (SSVEP inside the video of human walking 3D-animation in three conditions: Normal; Upside-down (inverted images; and Uncoordinated (pseudo-randomly mixed images. We found that early visual evoked response P120 was decreased in Upside-down condition. The N170 and P300b amplitudes were decreased in Uncoordinated condition. In Upside-down and Uncoordinated conditions, we found decreased alpha power and theta phase-locking. As regards gamma oscillation, power was increased during the Upside-down animation and decreased during the Uncoordinated animation. An SSVEP-like response oscillating at about 10 Hz was also described showing that the oscillating pattern is enhanced 300 ms after the heel strike event only in the Normal but not in the Upside-down condition. Our results are consistent with most of previous point-light display studies, further supporting possible use of virtual reality for neurofeedback applications.

  3. Muusikamaailm : Kümme aastat Rheinsbergi festivali. Birminghami Symphony Hall 10. "Tampereen Sävel". Vytautas Barkauskas 70. Alberto Erede lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Rheinsbergi muusikafestivalist Saksamaal. Birminghami kontserdisaalist, juubelikontserdist. Koorifestivalist "Tampereen Sävel" Soomes. V. Barkauskase juubelikontserdist Vilniuses. Lühidalt A. Eredest

  4. Arensky. Silhouettes (Suite N 2), Op. 23 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Arensky. Silhouettes (Suite N 2), Op. 23. Scrjabin. Symphony N 3 in C minor, Op. 43 "Le divin poeme". Danish National Radio Symphony Orchestra. Neeme Järvi. Chandos cassette ABTD 1509; CD CHAN 8898 (66 minutes)

  5. Lepo Sumera. Musica tenera / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1995-01-01

    Uuest heliplaadist "Sumera, Lepo. Musica tenera. Concerto for Piano and Orchestra. Symphony Nr. 4, "Serena borealis". Kalle Randalu (pf). Malmö Symphony Orchestra, Paavo Järvi" BIS CD CD690 (55 minutes)

  6. Hindemith: Symphonic Metamorphosis on Themes of Carl Maria von Weber / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1990-01-01

    Uuest heliplaadist "Hindemith: Symphonic Metamorphosis on Themes of Carl Maria von Weber, Mathis der Maler - Symphony, Nobilissima visione - suite. Atlanta Symphony Orchestra, Yoel Levi" Telarc/ Conifer CD 80 195

  7. Pärt, Arvo. Cantus in memory of Benjamin Britten / Andrew Achenbach

    Index Scriptorium Estoniae

    Achenbach, Andrew

    1995-01-01

    Uuest heliplaadist "Pärt, Arvo. Cantus in memory of Benjamin Britten. BBC Northern Symphony Orchestra / Norman del Mar; BBC Symphony Orchestra / Gennady Rozhdestvensky". BBC Radio Classics CD BBCRD 9129 (71 minutes)

  8. 76 FR 18519 - Polyethylene Terephthalate Film, Sheet, and Strip From Taiwan: Amended Final Results of...

    Science.gov (United States)

    2011-04-04

    ... 9745 (February 22, 2011) (Final Results) and accompanying Issues and Decision Memorandum (IDM). DATES.... \\10\\ See id. \\11\\ See IDM at Comment 1. Amended Final Results Therefore, in accordance with section...

  9. 75 FR 13090 - Privacy Act of 1974; System of Records

    Science.gov (United States)

    2010-03-18

    ... Management (IDM) System location: Defense Information Systems Agency (DISA), 401 East Moore Drive, Montgomery... Management (IDM) process and provides approval for new users to gain access to additional systems within DISA...

  10. Determination of tributyltin (TBT) in marine sediment using pressurised liquid extraction-gas chromatography-isotope dilution mass spectrometry (PLE-GC-IDMS) with a hexane-tropolone mixture.

    Science.gov (United States)

    Konieczka, Piotr; Sejerøe-Olsen, Berit; Linsinger, Thomas P J; Schimmel, Heinz

    2007-06-01

    Extraction conditions for the determination of tributyltin (TBT) in sediment samples have been developed further. The analytical procedure is based on spiking with isotopically labelled analyte, pressurised liquid extraction (PLE) with a hexane/tropolone mixture, Grignard derivatization and quantification by GC-MS. It was applied to two unknown sediment samples as part of an intercomparison exercise of the Comité Consultatif pour la Quantité de Matière (CCQM). The detection limit was approximately 1.5 ng/g TBT as Sn, while the repeatability and intermediate precision (as the coefficient of variation) were 1.9% and 3.2%, respectively. The expanded uncertainty was 6.2% (coverage factor k = 2), and the accuracy was confirmed by measurement of a certified reference material.

  11. Neonatal outcomes of macrosomic infants of diabetic and non-diabetic mothers.

    Science.gov (United States)

    Cordero, L; Paetow, P; Landon, M B; Nankervis, C A

    2015-01-01

    To compare neonatal outcomes (including breastfeeding (BF) initiation) of 170 macrosomic IDM with that of 739 macrosomic nIDM. Retrospective cohort investigation of all macrosomic infants born consecutively over a four-year period (2008-2011). Macrosomic (birth weight ≥4000 g) IDM included 100 infants whose mothers had gestational diabetes and 70 whose mothers had pregestational diabetes. IDM were more likely to be delivered by cesarean to obese women while nIDM were more likely to be delivered vaginally to younger women with a higher level of education. Ethnic distribution (60% white, 20% black, 10% Hispanic and 10% Asian or African) was similar in each group. Forty-nine percent of IDM and 7% of nIDM required NICU admission. Respiratory disorders (mainly TTNB) affected 21% of IDM and 3% of nIDM while hypoglycemia was observed in 36% of IDM and 15% of nIDM. Of the 35 IDM delivered vaginally, 10 were complicated by shoulder dystocia without injury. Conversely, 70 of the 458 nIDM delivered vaginally experienced shoulder dystocia that resulted in 6 limb fractures and 3 brachial plexus injuries. On arrival to labor and delivery, 75% of all women intended to BF; however, at the time of discharge, 65% of women with diabetes and 92% of those without diabetes who intended to BF had initiated BF. Both macrosomic IDM and macrosomic nIDM are at risk for significant morbidities. Macrosomic IDM carry a higher risk for NICU admissions, leading to maternal-infant separation, and lower BF initiation rates.

  12. Ontology for Life-Cycle Modeling of Water Distribution Systems: Model View Definition

    Science.gov (United States)

    2013-06-01

    requirements, the team followed the Information Delivery Manual ( IDM ) and Model View Definition (MVD) procedures defined by the International Organization...MVD_Format_V2_Proposal_080128.pdf. Wix, J., ed. 2007. “Information Delivery Manual: Guide to Components and Development Methods,” http://www.iai.no/ idm /idm_resources

  13. Predictive factors of isolated distant metastasis after primary definitive surgery without systemic treatment for head and neck squamous cell carcinoma.

    Science.gov (United States)

    Lim, Jae-Yol; Lim, Young Chang; Kim, Se-Heon; Kim, Jae Wook; Jeong, Ha Min; Choi, Eun Chang

    2010-07-01

    Incidence of isolated distant metastasis (IDM) was relatively low in patients who achieved locoregional control after primary definitive surgery. However, the prognosis of patients with IDM was dismal. The aim of this study was to evaluate the clinical outcome of patients with IDM and identify independent predictive factors of IDM after primary definitive surgery for head and neck squamous cell carcinoma (HNSCC). A retrospective data review was conducted for 795 patients who underwent primary definitive surgery without any systemic treatment for squamous cell carcinoma (SCC) of the oral cavity, oropharynx, larynx, and hypopharynx. Distant metastasis-free survival was calculated and independent predictive factors for IDM were determined by Cox proportional-hazards model. For the entire study cohort, IDM developed in 75 patients (9.4%). Among 631 patients who achieved locoregional control, IDM occurred in 44 patients (7%). The median time to IDM after primary surgery was 13months, ranging from 2 to 70months. The overall salvage rate was 9% (4 of 44) after salvage treatment for IDM. In the Cox proportional-hazards model, clinical N status, and histological grade were independent predictive factors of IDM. Patients who had clinically palpable neck disease and a histologically poor grade were more likely to develop IDM after primary definitive surgery. Patients with these factors should be considered candidates for proper adjuvant systemic treatment and evaluated more thoroughly for early detection of IDM during follow-up.

  14. Security controls in a Cullinet database environment

    International Nuclear Information System (INIS)

    Thompson, R.E.

    1988-01-01

    Security controls using Cullinet's Integrated Data Management System (IDMS) are examined. IDMS software integrity problems, with emphasis on security package interfaces, are disclosed. Solutions applied at Sandia Laboratories Engineering Information Management computing facilty are presented. An overall IDMS computer security philosophy is reviewed

  15. Absence of increase in carotid artery intima-media thickness in infants of diabetic mothers.

    Science.gov (United States)

    Atabek, Mehmet Emre; Çağan, Havva Hasret; Selver Eklioğlu, Beray; Oran, Bülent

    2011-01-01

    Infants of diabetic mothers (IDM) are considered as a risk group for atherosclerosis. Increased aortic intima-media thickness has been reported in IDM. The purpose of this study was to assess carotid artery intima-media thickness (CA-IMT), left ventricular mass index (LVMI) and atherosclerotic risk factors in IDM. Thirty IDM and 25 healthy controls were included in the study. Of these infants, 14 were appropriate-for-gestational age (AGA) and 16 were large-for-gestational age (LGA). CA-IMT and LVMI were obtained by M-mode echocardiographic examination. The relationship between parameters of atherosclerosis and echocardiographic measurements was assessed by Pearson's correlation analysis. LVMI was higher in LGA IDM when compared to AGA IDM and controls. CA-IMT was not significantly different between the groups and was also not related to atherosclerotic risk factors. Serum lipid and insulin levels were higher in LGA IDM when compared with AGA IDM and controls. There were no correlations between CA-IMT, LVMI and atherosclerotic risk factors. In contrast to previous reports indicating an increase in CA-IMT in IDM, no differences were found between IDM and controls in this study. Our results indicate that macrosomic IDM are prone to hypertrophic cardiomyopathy but not to atherosclerotic changes in the blood vessels.

  16. Introducing a new framework for using generic Information Delivery Manuals

    DEFF Research Database (Denmark)

    Mondrup, Thomas Fænø; Treldal, Niels; Karlshøj, Jan

    2014-01-01

    to resolve this issue is based on the Information Delivery Manual (IDM). The IDMs in current use indicate that focus has mainly been on formalizing multifaceted and wide-ranging AEC/FM processes, and therefore often involve multiple use cases. Because IDMs typically describe such complex processes...... generic IDM Packages for all main use cases of the AEC/FM project life cycle. In this methodology, an IDM Project Plan can be created by selecting the specific IDM Packages required for the specific AEC/FM project. Ultimately, we believe that the IDM Framework will help improve information flow management...... is also necessary, if improved interoperability between AEC/FM software tools is the goal....

  17. Simfoni No. 40 Bagian Pertama Wolfgang Amadeus Mozart

    Directory of Open Access Journals (Sweden)

    F. XAVERIA DIAH K

    2013-11-01

    Full Text Available The First Symfoni No 40 Wolfgang Amadeus Mozart. Symphony is a great composition, whichconventionally consists of four parts. At the end of the eighteenth century it became the main format of orchestralmusic. However, it became prominent at the time of Beethoven. Symphony is a great and ambitious piece of musicsince it is played for 20-45 minutes in length, containing an expansion of tone colors and dynamics of classicalorchestra. It has been known that classical symphony usually consists of four parts inciting broader emotion bythe created tempo and nuance. Mozart’s three last symphonies are Mozart’s masterpieces and Symphony No. 40,for example, contains connotations of romantic signs ignored by his predecessors. Although Symphony No. 40employs minor tones, it is not sad but cheerful, playful, passionful, and dramatic. The fi rst part of the Symphonyuses Allegro Sonata format which consists of three parts, namely exposition, development and recapitulation.

  18. Looking for a Symphony: A Sort of Essay with a Perspective on Activity Theories and the Ontology of Psychology: Learning from Danish and Russian Experiences by Jens Mammen & Irina Mironenko.

    Science.gov (United States)

    Neumann, Asger

    2016-06-01

    As a perspective on Mammen and Miroenkos the article is reflecting on the possibility of Activity Theory being a foundation on which Psychology could be integrated. Mammen and Miroenkos point that directed activity not only is towards objects "defined as a sum of qualities, but by individual reference" is a starting point. As a specific example the phenomenon Love, as "significant object relations", is related to the concept "choice categories". It is stated that relations of affection and love can't be understood independent of history of common activity, and that this makes the concept "choice categories" central in a psychological understanding of what love is.

  19. Measurement uncertainty in single, double and triple isotope dilution mass spectrometry.

    Science.gov (United States)

    Vogl, Jochen

    2012-02-15

    Triple IDMS has been applied for the first time to the quantification of element concentrations. It has been compared with single and double IDMS obtained on the same sample set in order to evaluate the advantages and disadvantages of triple IDMS over single and double IDMS as an analytical reference procedure. The measurement results of single, double and triple IDMS are indistinguishable, considering rounding due to the individual measurement uncertainties. As expected, the relative expanded uncertainties (k = 2) achieved with double IDMS (0.08%) are dramatically smaller than those obtained with single IDMS (1.4%). Triple IDMS yields the smallest relative expanded uncertainties (k = 2, 0.077%) unfortunately at the expense of a much higher workload. Nevertheless triple IDMS has the huge advantage that the isotope ratio of the spike does not need to be determined. Elements with high memory effects, highly enriched spikes or highest metrological requirements may be typical applications for triple IDMS. Copyright © 2011 John Wiley & Sons, Ltd.

  20. ECM. Kauneim heli pärast vaikust / Immo Mihkelson

    Index Scriptorium Estoniae

    Mihkelson, Immo, 1959-

    2007-01-01

    Uutest Saksa plaadifirma ECM heliplaatidest Frode Haltli "Passing Images", Roscoe Mitchell "The Transatlantic Art Ensemble Composition", Chritian Wallumrod "TRhe Zoo Is Far", Valentin Silvestrov "Symphony No. 6"

  1. Muusikamaailm / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    1999-01-01

    Sibeliuse kogutud teostest, Ashkenazy lahkumisest Lääne-Berliini Raadio Sümfooniaorkestri juurest, Natonal Symphony Orcestra kontsertidest Hiinas ja Jaapanis, Viini klassikutele orienteeritud kammerorkestri tegevusest

  2. Using the Arts To Acquire and Enhance Management Skills.

    Science.gov (United States)

    Mockler, Robert J.

    2002-01-01

    Draws analogies between strategic management and experiences found in dramatic literature and symphony conducting. Provides examples of using the arts to support management learning. (Contains 50 references.) (SK)

  3. Security and privacy enablers for future identity management systems: Presentation held at Future Network & MobileSummit 2010, 16-18 June 2010, Florence, Italy

    OpenAIRE

    Barisch, M.; Torroglosa Garcia, E.; Lischka, M.; Marques, R.; Marx, R.; Matos, A.; Perez Mendez, A.; Scheuermann, D.

    2010-01-01

    In recent years, Identity Management (IdM) has gained a lot of attention in industry, standardisation and academia. In particular, a couple of research projects, like Daidalos or Prime, have invested considerable effort to bring IdM forward, to take advantage of features like improved usability and security. Nevertheless, there are important issues that have not been addressed so far. The SWIFT project leverages IdM as a key technology of the Future Internet, tackling problems like the integr...

  4. Key Management Infrastructure Increment 2 (KMI Inc 2)

    Science.gov (United States)

    2016-03-01

    with IDM requirements for semantic tagging, search accuracy, and relevance of information returned from a search, as identified in the GIG-IA ICD. 5... IDM semantic tagging and search accuracy and relevance requirements shall be applied to that portion of the KMI archive that is accessible online...Grid IDM - Information Dissemination Management IOT&E - Initial Operational Test & Evaluation JTRS - Joint Tactical Radio System JWICS - Joint Worldwide

  5. Improvement of DHRA-DMDC Physical Access Software DBIDS Using Cloud Computing Technology: A Case Study

    Science.gov (United States)

    2012-06-01

    DISTRIBUTION CODE 13. ABSTRACT (maximum 200words) The U.S government has created and been executing an Identity and Management ( IdM ) vision to...cloud-based architecture will move DBIDS in the right direction to meet Dod IdM visions and goals by decoupling current DBIDS functions into DBIDS...DBIDS application. This is a step closer in moving DMDC Identity Enterprise Solution toward DoD IdM realizing vision and goals. The thesis also

  6. Ionosphere-Thermosphere Coupling - Data Analysis and Numerical Simulation Study

    Science.gov (United States)

    2013-12-12

    horizontal component of Ion Drift Meter ( IDM ) data measured by DMSP F16 from 0030 UT to 0106 UT on August 6, 2011...magnetometers (Special Sensor for Magnetic Fields, SSM) and Ion Drift Meter ( IDM ) on the satellite to obtain particle number fluxes and energy spectra and...the horizontal and vertical directions, measured by the IDM , were used to calculate the electric fields, with the in-track velocity component ignored

  7. Perceptions of Prostate Cancer Screening Controversy and Informed Decision Making: Implications for Development of a Targeted Decision Aid for Unaffected Male First-Degree Relatives.

    Science.gov (United States)

    Gwede, Clement K; Davis, Stacy N; Wilson, Shaenelle; Patel, Mitul; Vadaparampil, Susan T; Meade, Cathy D; Rivers, Brian M; Yu, Daohai; Torres-Roca, Javier; Heysek, Randy; Spiess, Philippe E; Pow-Sang, Julio; Jacobsen, Paul

    2015-01-01

    First-degree relatives (FDRs) of prostate cancer (PC) patients should consider multiple concurrent personal risk factors when engaging in informed decision making (IDM) about PC screening. This study assessed perceptions of IDM recommendations and risk-appropriate strategies for IDM among FDRs of varied race/ethnicity. A cross-sectional, qualitative study design was used. Study setting was a cancer center in southwest Florida. The study comprised 44 participants (24 PC patients and 20 unaffected FDRs). Focus groups and individual interviews were conducted and analyzed using content analysis and constant comparison methods. Patients and FDRs found the PC screening debate and IDM recommendations to be complex and counterintuitive. They overwhelmingly believed screening saves lives and does not have associated harms. There was a strongly expressed need to improve communication between patients and FDRs. A single decision aid that addresses the needs of all FDRs, rather than one separating by race/ethnicity, was recommended as sufficient by study participants. These perspectives guided the development of an innovative decision aid that deconstructs the screening controversy and IDM processes into simpler concepts and provides step-by-step strategies for FDRs to engage in IDM. Implementing IDM among FDRs is challenging because the IDM paradigm departs from historical messages promoting routine screening. These contradictions should be recognized and addressed for men to participate effectively in IDM. A randomized pilot study evaluating outcomes of the resulting decision aid is underway.

  8. Measuring informed decision making about prostate cancer screening in primary care.

    Science.gov (United States)

    Leader, Amy; Daskalakis, Constantine; Braddock, Clarence H; Kunkel, Elisabeth J S; Cocroft, James R; Bereknyei, Sylvia; Riggio, Jeffrey M; Capkin, Mark; Myers, Ronald E

    2012-01-01

    To measure the extent of informed decision making (IDM) about prostate cancer screening in physician-patient encounters, describe the coding process, and assess the reliability of the IDM measure. Audiorecoded encounters of 146 older adult men and their primary care physicians were obtained in a randomized controlled trial of mediated decision support related to prostate cancer screening. Each encounter was dual coded for the presence or absence of 9 elements that reflect several important dimensions of IDM, such as information sharing, patient empowerment, and engaging patients in preference clarification. An IDM-9 score (range = 0-9) was determined for each encounter by summing the number of elements that were coded as present. Estimates of coding reliability and internal consistency were calculated. Male patients tended to be white (59%), married (70%), and between the ages of 50 and 59 (70%). Physicians tended to be white (90%), male (74%), and have more than 10 years of practice experience (74%). IDM-9 scores ranged from 0 to 7.5 (mean [SD], 2.7 [2.1]). Reliability (0.90) and internal consistency (0.81) of the IDM-9 were both high. The IDM dimension observed most frequently was information sharing (74%), whereas the dimension least frequently observed was engagement in preference clarification (3.4%). In physician-patient encounters, the level of IDM concerning prostate cancer screening was low. The use of a dual-coding approach with audiorecorded encounters produced a measure of IDM that was reliable and internally consistent.

  9. Stimmen des Leis, schillernde Gewebe / Christoph Schlüren

    Index Scriptorium Estoniae

    Schlüren, Christoph

    1995-01-01

    Baltische Werke für Streichorchester: Vol. 1: Balakauskas: Ostrobothnian Symphony, Vasks: Symphonie "Stimmen", Narbutaite: Opus Lugubre; Vol. 2: Kutavicius: Nothern Gates, Vasks: Cantabile, Tüür: Insula Deserta, Rekasius: Music for strings, Werke von Urbaitis und Juozapaitis; Ostrobothnian Chamber Orchestra, Dirigent: Juha Kangas; Finlandia / east-west CD-s 4509-97892-2 und 4509-97893-2. Vasks: Cantabile, Englischhorn-Konzert, Botschaft, Musica dolorosa, Lauda; Riga Philarmonic Orchestra, Dirigent: Kriss Rusmanis; Confer / BMG 75605-51236-2. Eller: Morgenrot, Abendrot, 5 Stücke für Streicher, Geister, Im Schatten und im Sonnenlicht, Elegia; Estonian Symphony Orchestra, Dirigent: Peeter Lilje; Forte FD 0020/2. Tubin: 11. Symphonie, Elegie für Streicher, Raid: 2. Symphonie; Estnisches Staatliches Symphonieorchester, Dirigent: Arvo Volmer; Koch 3-7291-2 H1. Sumera: Symphonien 1-3; Malmö Symphony Orchestra, Dirigent: Paavo Järvi; BIS/Disco-Center 660. Sumera: Klavierkonzert, 4. Symphonie, Musica tenera; Malmö Symphony Orchestra, Dirigent: Paavo Järvi; BIS/Disco-Center 690. Tormis: Werke für Männerchor; Estnischer Nationaler Männerchor, Dirigent: Olev Oja; Forte CDs FD 0011/2 und FD 0019/2 Tutvustatakse uusi heliplaate Baltimaade heliloojate loomingust.

  10. Russian orchestral works. Torgny Sporsen / Ivan March

    Index Scriptorium Estoniae

    March, Ivan

    1991-01-01

    Uuest heliplaadist "Russian orchestral works. Torgny Sporsen (bass). Gothenburg Symphony Brass Band. Gothenburg Symphony Chorus and Orchestra / Neeme Järvi" D6 MC 429 984 - 4 GH; CD 429 984 - 26H (76 minutes). Borodin: In Central Asia. Prince Igor - Polovtsian Dances

  11. Mahler: Sinfonie Nr. 8 Es-Dur (Sinfonie der Tausend) / Norbert Rüdell

    Index Scriptorium Estoniae

    Rüdell, Norbert

    1995-01-01

    Uuest heliplaadist "Mahler: Sinfonie Nr. 8 Es-Dur (Sinfonie der Tausend). Estonian Boys' Choir, Brunnsbo Children's Choir, Gothenburg Opera Chorus, Royal Stockholm Philharmonic Choir, Gothenburg Symphony Chorus, Gothenburg Opera Chorus, Gothenburg Symphony Orchestra, Neeme Järvi. BIS/Disco-Center CD 700 (WD:72'18")

  12. Searching for Roots / Pierre Gervasoni

    Index Scriptorium Estoniae

    Gervasoni, Pierre

    1997-01-01

    Uuest heliplaadist "Searching for Roots. Eduard Tubin: Symphonie no 11; Arvo Pärt: Nekrolog-Symphonie no 1; Erkki-Sven Tüür: Searching for Roots - Insula deserta - Zeitraum; Orchestre philharmonique royal de Stockholm, Paavo Järvi (direction)" Virgin Classics 5 45212 2 (distribue par EMI)

  13. Hulot, Jean-Claude / Pierre Gervasoni

    Index Scriptorium Estoniae

    Gervasoni, Pierre

    1997-01-01

    Uuest heliplaadist "Searching for Roots. Eduard Tubin: Symphonie no 11; Arvo Pärt: Nekrolog-Symphonie no 1; Erkki-Sven Tüür: Searching for Roots - Insula deserta - Zeitraum; Orchestre philharmonique royal de Stockholm, Paavo Järvi (direction); Virgin Classics 5 45212 2 (distribue par EMI)

  14. Development of a selective molecularly imprinted polymer-based solid-phase extraction for indomethacin from water samples.

    Science.gov (United States)

    Yang, Tao; Li, Ya-Hui; Wei, Shuang; Li, Yuan; Deng, Anping

    2008-08-01

    A selective molecularly imprinted solid-phase extraction (MISPE) for indomethacin (IDM) from water samples was developed. Using IDM as template molecule, acrylamide (AM) or methacrylic acid (MAA) as functional monomer, ethylene dimethacrylate (EDMA) as crosslinker, and bulk or suspension polymerization as the synthetic method, three molecularly imprinted polymers (MIPs) were synthesized and characterized with a rebinding experiment. It was found that the MIP of AM-EDMA produced by bulk polymerization showed the highest binding capacity for IDM, and so it was chosen for subsequent experiments, such as those testing the selectivity and recognition binding sites. Scatchard analysis revealed that at least two kinds of binding sites formed in the MIP, with the dissociation constants of 7.8 micromol L(-1) and 127.2 micromol L(-1), respectively. Besides IDM, three structurally related compounds--acemetacin, oxaprozin and ibuprofen--were employed for selectivity tests. It was observed that the MIP exhibited the highest selective rebinding to IDM. Accordingly, the MIP was used as a solid-phase extraction sorbent for the extraction and enrichment of IDM in water samples. The extraction conditions of the MISPE column for IDM were optimized to be: chloroform or water as loading solvent, chloroform with 20% acetonitrile as washing solution, and methanol as eluting solvent. Water samples with or without spiking were extracted by the MISPE column and analyzed by HPLC. No detectable IDM was observed in tap water and the content of IDM in a river water sample was found to be 1.8 ng mL(-1). The extraction efficiencies of the MISPE column for IDM in spiked tap and river water were acceptable (87.2% and 83.5%, respectively), demonstrating the feasibility of the prepared MIP for IDM extraction.

  15. Protective effects of indomethacin and dexamethasone in a goat model with intrauterine balloon aortic valvuloplasty.

    Science.gov (United States)

    Zhou, Kaiyu; Wu, Gang; Li, Yifei; Zhao, Liang; Zhou, Rong; Zhu, Qi; Huang, Xupei; Mu, Dezhi; Hua, Yimin

    2012-08-13

    Intrauterine balloon aortic valvuloplasty (IUBAV) has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to find a way to prevent or reduce them. In the present study, we evaluated the therapeutic value of indomethacin (IDM) and dexamethasone (DXS) on reducing the preterm birth rate in experimental goats after IUBAV. Our results indicated that the administration of IDM/DXS significantly reduced the rate of premature birth. IDM/DXS treatment led to preservation of myocardial ultrastructure with less damage, and amelioration of the fetal and placental circulation. Furthermore, we found that norepinephrine (NE) level was positively associated with the degree of myocardial damage. IDM/DXS administration led to a significant decrease of operation-induced increase of NE levels, which may be associated with the protective effects of IDM/DXS. Lastly, we found that the administration of IDM/DXS did not induce the risk of ductus arteriosus closure or slow down fetal growth. Our results indicate that IDM/DXS promotes a better gestational outcome at least partially by reducing stress response during and after the operation of IUBAV in the goat model. IDM/DXS may be a useful application in human patients during IUBAV intervention.

  16. A Grounded Theory Study of Teachers' Decision Making.

    Science.gov (United States)

    Parker, Walter C.; Gehrke, Nathalie

    Interactive decision making (IDM) refers to teachers' selection and rejection of alternative courses of action during instruction. Previous research indicates that teachers report making interactive decisions when their plans are disrupted. A study generated hypotheses about teachers' IDM using the grounded theory approach--an inductive system for…

  17. Protective effects of indomethacin and dexamethasone in a goat model with intrauterine balloon aortic valvuloplasty

    Directory of Open Access Journals (Sweden)

    Zhou Kaiyu

    2012-08-01

    Full Text Available Abstract Background Intrauterine balloon aortic valvuloplasty (IUBAV has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to find a way to prevent or reduce them. Methods In the present study, we evaluated the therapeutic value of indomethacin (IDM and dexamethasone (DXS on reducing the preterm birth rate in experimental goats after IUBAV. Results Our results indicated that the administration of IDM/DXS significantly reduced the rate of premature birth. IDM/DXS treatment led to preservation of myocardial ultrastructure with less damage, and amelioration of the fetal and placental circulation. Furthermore, we found that norepinephrine (NE level was positively associated with the degree of myocardial damage. IDM/DXS administration led to a significant decrease of operation-induced increase of NE levels, which may be associated with the protective effects of IDM/DXS. Lastly, we found that the administration of IDM/DXS did not induce the risk of ductus arteriosus closure or slow down fetal growth. Conclusions Our results indicate that IDM/DXS promotes a better gestational outcome at least partially by reducing stress response during and after the operation of IUBAV in the goat model. IDM/DXS may be a useful application in human patients during IUBAV intervention.

  18. Energy Coupling During the August 2011 Magnetic Storm (Postprint)

    Science.gov (United States)

    2014-08-27

    drift meter ( IDM ) to measure horizontal (VH) and vertical (VV) cross-track components of the plasma drift, and (3) a retarding potential analyzer...velocities from the IDM , together with the measured values of dB made by the SSM and B from the International Reference Geomagnetic Field (IGRF

  19. The Integrated Developmental Model of Supervision.

    Science.gov (United States)

    Stoltenberg, Cal D.

    The Integrated Developmental Model (IDM) of supervision builds upon previous models of counselor and psychotherapist development. The IDM incorporates aspects of both a mechanistic view, using the machine as metaphor, and an organismic view, using the organism as metaphor, of development in describing trainee development through three levels and…

  20. Deterring Malicious Behavior in Cyberspace

    Science.gov (United States)

    2015-01-01

    with malicious capability and intent to affect key cyber terrain. Sub- categories of these operations are internal defensive measures ( IDM ), actions...taken internally, and response actions (RA) taken outside the information environment. Tasks for IDM are hunting on friendly ter- rain for threats

  1. Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising

    NARCIS (Netherlands)

    Golla, Sandeep S. V.; Lubberink, Mark; van Berckel, Bart N. M.; Lammertsma, Adriaan A.; Boellaard, Ronald

    2017-01-01

    Background: Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have been proposed as a means to correct for PVE. IDM improves spatial resolution

  2. XSIM Final Report: Modelling the Past and Future of Identity Management for Scientific Collaborations

    Energy Technology Data Exchange (ETDEWEB)

    Cowles, Robert; Jackson, Craig; Welch, Von

    2016-08-31

    The eXtreme Science Identity Management (XSIM1) research project: collected and analyzed real world data on virtual organization (VO) identity management (IdM) representing the last 15+ years of collaborative DOE science; constructed a descriptive VO IdM model based on that data; used the model and existing trends to project the direction for IdM in the 2020 timeframe; and provided guidance to scientific collaborations and resource providers that are implementing or seeking to improve IdM functionality. XSIM conducted over 20 semi­structured interviews of representatives from scientific collaborations and resource providers, both in the US and Europe; the interviewees supported diverse set of scientific collaborations and disciplines. We developed a definition of “trust,” a key concept in IdM, to understand how varying trust models affect where IdM functions are performed. The model identifies how key IdM data elements are utilized in collaborative scientific workflows, and it has the flexibility to describe past, present and future trust relationships and IdM implementations. During the funding period, we gave more than two dozen presentations to socialize our work, encourage feedback, and improve the model; we also published four refereed papers. Additionally, we developed, presented, and received favorable feedback on three white papers providing practical advice to collaborations and/or resource providers.

  3. N-Phenyl heteroarylamine analogues of fluazinam using the ...

    Indian Academy of Sciences (India)

    erated patentable leads and target compounds.4–9. The essence of IDM is to apply simple organic chemical ... like grey mould and downy mildew on vines; apple scab, southern blight and white mould on peanuts; ... trolling mites in apples as well.17 In our previous study,18 we used the IDM approach starting with 2,6-.

  4. Validation of the Korean coefficient for the modification of diet in renal disease study equation.

    Science.gov (United States)

    Oh, Yun Jung; Cha, Ran-Hui; Lee, Seung Hwan; Yu, Kyung Sang; Kim, Satbyul Estella; Kim, Ho; Kim, Yon Su

    2016-03-01

    Race and ethnicity are important determinants when estimatingglomerular filtration rate (GFR). The Korean coefficients for the isotope dilution mass spectrometry (IDMS) Modification of Diet in Renal Disease (MDRD) Study equations were developed in 2010. However, the coefficients have not been validated. The aim of this study was to validate the performance of the Korean coefficients for the IDMS MDRD Study equations. Equation development and validation were performed in separate groups (development group, n = 147 from 2008 to 2009; validation group, n = 125 from 2010 to 2012). We compared the performance of the original IDMS MDRD equations and modified equations with Korean coefficients. Performance was assessed by comparing correlation coefficients, bias, and accuracy between estimated GFR and measured GFR, with systemic inulin clearance using a single injection method. The Korean coefficients for the IDMS MDRD equations developed previously showed good performance in the validation group. The new Korean coefficients for the four- and six-variable IDMS MDRD equations using both the development and validation cohorts were 1.02046 and 0.97300, respectively. No significant difference was detected for the new Korean coefficients, in terms of estimating GFR, between the original and modified IDMS MDRD Study equations. The modified equations with Korean coefficients for the IDMS MDRD Study equations were not superior to the original equations for estimating GFR. Therefore, we recommend using the original IDMS MDRD Study equation without ethnic adjustment in the Korean population.

  5. A Research Approach into Science Education at Goteborg. Paper Presented at the Joint ICMI/ICPE/CTS/UNESCO/IDM Conference (Institut fur Didaktik der Mathematik, Bielefeld, West Germany, September 17-23, 1978). Reports from the Institute of Education, University of Goteborg, No. 71.

    Science.gov (United States)

    Lybeck, Leif

    This paper reports on research carried out in Sweden on concept formation as related to science education. Particular emphasis is given to the aquisition of the concepts of proportionality and density by tenth-grade students. Comparisons were made of the student's everyday thoughts about density and their ability to understand the Cartesian Diver…

  6. Studies of Mathematics in Teaching of Science in Goteborg. Paper Presented at the Joint ICMI/ICPE/CTS/UNESCO/IDM Conference (Institut fur Didaktik der Mathematik, Bielefeld, West Germany, September 17-23, 1978). Reports from the Institute of Education, University of Goteborg, No. 72.

    Science.gov (United States)

    Lybeck, Leif

    This investigation looks at the difficulties tenth-grade students have with the concept of proportionality and the problems this causes in tenth-grade physics. Students were asked to solve various problems in the areas of volume measurement and weight, all relating to proportionality, and their approaches to the tasks were recorded. As a result,…

  7. In-vitro and in-vivo study of indomethacin loaded gelatin nanoparticles.

    Science.gov (United States)

    Kumar, Rakesh; Nagarwal, Ramesh C; Dhanawat, Meenakshi; Pandit, Jayanta Kumar

    2011-06-01

    The present research work deals with fabrication of indomethacin loaded gelatin nanoparticles prepared by double desolvation method for controlled drug delivery. Submicron polymeric particles with size 20% in 1 hr) followed by controlled release (> 75% in 12 hr). Among the kinetic models employed, the Higuchi model showed a better fit (R2 > 0.9) with n IDM) was studied by rat paw model and IGNP significantly (P IDM. Pharmacokinetic study showed significant enhancement (P IDM. Cmax of IGNP had higher value (110.81 +/- 8.53 microg/mL) compared to that of IDM (51.66 +/- 7.5 microg/mL). AUC0-12 was 1009.78 +/- 80.24 and 194.33 +/- 46.76/microg x h/mL in IGNP and IDM respectively (relative bioavailability 500%). Further, a good in vitro-in vivo correlation established the formulation for future trials.

  8. Thickness dependence of the interfacial Dzyaloshinskii–Moriya interaction in inversion symmetry broken systems

    Science.gov (United States)

    Cho, Jaehun; Kim, Nam-Hui; Lee, Sukmock; Kim, June-Seo; Lavrijsen, Reinoud; Solignac, Aurelie; Yin, Yuxiang; Han, Dong-Soo; van Hoof, Niels J. J.; Swagten, Henk J. M.; Koopmans, Bert; You, Chun-Yeol

    2015-01-01

    In magnetic multilayer systems, a large spin-orbit coupling at the interface between heavy metals and ferromagnets can lead to intriguing phenomena such as the perpendicular magnetic anisotropy, the spin Hall effect, the Rashba effect, and especially the interfacial Dzyaloshinskii–Moriya (IDM) interaction. This interfacial nature of the IDM interaction has been recently revisited because of its scientific and technological potential. Here we demonstrate an experimental technique to straightforwardly observe the IDM interaction, namely Brillouin light scattering. The non-reciprocal spin wave dispersions, systematically measured by Brillouin light scattering, allow not only the determination of the IDM energy densities beyond the regime of perpendicular magnetization but also the revelation of the inverse proportionality with the thickness of the magnetic layer, which is a clear signature of the interfacial nature. Altogether, our experimental and theoretical approaches involving double time Green's function methods open up possibilities for exploring magnetic hybrid structures for engineering the IDM interaction. PMID:26154986

  9. Integrated Disability Management

    Directory of Open Access Journals (Sweden)

    Silvia Angeloni

    2013-10-01

    Full Text Available This article sets out to increase awareness regarding the wide and universal significance of disability, as well as the important benefits of an Integrated Disability Management (IDM approach. The scientific basis for IDM is explored in the first place through an analysis of its relationship to the International Classification of Functioning, Disability and Health (ICF. The conceptual paradigm of the ICF shares an ideological position with the IDM approach in that they are both underpinned by dynamic and multidimensional constructions of disability, which imply equally holistic and interdisciplinary responses. The IDM approach can be applied across a diversity of human situations to provide solutions that reflect the multifaceted and widespread nature of disability. The IDM approach is intended as a strategy capable of handling: inclusion of people with disabilities, active aging of human resources, health and safety in the workplace, prevention of disabilities and various diseases, return-to-work, absenteeism, and presenteeism.

  10. COPD: Health Care Utilisation Patterns with Different Disease Management Interventions.

    Science.gov (United States)

    Luk, Edwin K; Hutchinson, Anastasia F; Tacey, Mark; Irving, Louis; Khan, Fary

    2017-08-01

    The management of COPD is a significant and costly issue worldwide, with acute healthcare utilisation consisting of admissions and outpatient attendances being a major contributor to the cost. Pulmonary rehabilitation (PR) and integrated disease management (IDM) are often offered. Whilst there is strong evidence of physical and quality of life outcomes following IDM and PR, few studies have looked into healthcare utilisation. The aims of this study were to confirm whether IDM and PR reduce acute healthcare utilisation and to identify factors which contribute to acute health care utilisation or increased mortality. This was a retrospective cohort study of patients with COPD who were referred to IDM over a 10-year period. Patients were also offered an 8-week PR program. Data collected were matched with the hospital dataset to obtain information on inpatient, ED and outpatient attendances. 517 patients were enrolled to IDM. 315 (61%) also commenced PR and 220 (43%) completed PR. Patients who were referred to PR were younger and had less comorbidities (p IDM only and IDM + PR referred) had reductions in healthcare utilisation but the IDM-only group had greater reductions. A survival benefit (HR 0.68, 95% CI 0.50-0.92) was seen in those who were PR completers compared to patients who received IDM only. Patients with COPD who successfully complete PR in addition to participating in IDM have improved survival. IDM alone was effective in the reduction of healthcare utilisation; however, the addition of PR did not reduce healthcare usage further.

  11. Study of the seismic behaviour of the fast reactor cores; Etude du comportement sismique des coeurs de reacteurs a neutrons rapides

    Energy Technology Data Exchange (ETDEWEB)

    Cerqueira, E

    1998-12-31

    This work studies the seismic behaviour of fast neutrons reactor cores. It consists in analyzing the tests made on the models Rapsodie and Symphony by using the calculation code Castem 2000. Te difficulty is in the description of connections of the system and the effects of the fluid (calculation in water). The results for the programme Rapsodie are near the experimental results. For the programme Symphony, the calculations in air have allowed to represent the behaviour of fuel assemblies in a satisfying way. It is still to analyze the tests Symphony in water. (N.C.)

  12. Study of the seismic behaviour of the fast reactor cores

    International Nuclear Information System (INIS)

    Cerqueira, E.

    1998-01-01

    This work studies the seismic behaviour of fast neutrons reactor cores. It consists in analyzing the tests made on the models Rapsodie and Symphony by using the calculation code Castem 2000. Te difficulty is in the description of connections of the system and the effects of the fluid (calculation in water). The results for the programme Rapsodie are near the experimental results. For the programme Symphony, the calculations in air have allowed to represent the behaviour of fuel assemblies in a satisfying way. It is still to analyze the tests Symphony in water. (N.C.)

  13. Patient-provider discussions about colorectal cancer screening: who initiates elements of informed decision making?

    Science.gov (United States)

    Katz, Mira L; Broder-Oldach, Ben; Fisher, James L; King, Justin; Eubanks, Kathy; Fleming, Kelly; Paskett, Electra D

    2012-09-01

    Colorectal cancer (CRC) screening rates remain low among low-income minority populations. To evaluate informed decision making (IDM) elements about CRC screening among low-income minority patients. Observational data were collected as part of a patient-level randomized controlled trial to improve CRC screening rates. Medical visits (November 2007 to May 2010) were audio-taped and coded for IDM elements about CRC screening. Near the end of the study one provider refused recording of patients' visits (33 of 270 patients). Among all patients in the trial, agreement to be audio taped was 43.5 % (103/237). Evaluable patient (n = 100) visits were assessed for CRC screening discussion occurrence, IDM elements, and who initiated discussion of each IDM element. Patients were African American (72.2 %), female (63.7 %), with annual household incomes IDM elements was five; however, only two visits included five elements. The most common IDM element discussed in addition to the nature of the decision was the assessment of the patient's understanding in 16 (33.3 %) of the visits that included a CRC discussion. A patient activation intervention initiated CRC screening discussions with health care providers; however, limited IDM occurred about CRC screening during medical visits of minority and low-income patients.

  14. Informed and patient-centered decision-making in the primary care visits of African Americans with depression.

    Science.gov (United States)

    Hines, Anika L; Roter, Debra; Ghods Dinoso, Bri K; Carson, Kathryn A; Daumit, Gail L; Cooper, Lisa A

    2018-02-01

    We examined the prevalence and extent of informed decision-making (IDM) and patient-centered decision-making (PCDM) in primary care visits of African Americans with depression. We performed a cross-sectional analysis of audiotaped clinical encounters and post-visit surveys of 76 patients and their clinicians. We used RIAS to characterize patient-centeredness of visit dialogue. IDM entailed discussion of 3 components: the nature of the decision, alternatives, and pros/cons. PCDM entailed discussion of: lifestyle/coping strategies, knowledge/beliefs, or treatment concerns. We examined the association of IDM and PCDM with visit duration, overall patient-centeredness, and patient/clinician interpersonal ratings. Approximately one-quarter of medication and counseling decisions included essential IDM elements and 40% included at least one PCDM element. In high patient-centered visits, IDM was associated with patients feeling respected in counseling and liking clinicians in medication decisions. IDM was not related to clinician ratings. In low patient-centered visits, PCDM in counseling decisions was positively associated with patients feeling respected and clinicians respecting patients. The associations between IDM and PCDM with interpersonal ratings was moderated by overall patient-centeredness of the visit, which may be indicative of broader cross-cultural communication issues. Strengthening partnerships between depressed African Americans and their clinicians may improve patient-engaged decision-making. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. New elements for informed decision making: a qualitative study of older adults' views.

    Science.gov (United States)

    Price, Erika Leemann; Bereknyei, Sylvia; Kuby, Alma; Levinson, Wendy; Braddock, Clarence Henry

    2012-03-01

    To explore older adults' views of existing informed decision making (IDM) elements and investigate the need for additional elements. We recruited persons 65 and older to participate in six focus groups. Participants completed questionnaires about IDM preferences, and discussed videotapes of idealized patient-physician interactions in light of seven IDM elements: (1) discussion of the patient's role in decision making; (2) discussion of the clinical issue; (3) discussion of alternatives; (4) discussion of benefits/risks; (5) discussion of uncertainties; (6) assessment of patient understanding; and (7) exploration of patient preference. We used a modified grounded theory approach to assess agreement with existing IDM elements and identify new elements. In questionnaires, 97-100% of 59 participants rated each IDM element as "somewhat" or "very" important. Qualitative analysis supported existing elements and suggested two more: opportunity for input from trusted others, and discussion of decisions' impacts on patients' daily lives. Elements overlapped with global communication themes. Focus groups affirmed existing IDM elements and suggested two more with particular relevance for older patients. Incorporation of additional IDM elements into clinical practice can enhance informed participation of older adults in decision making. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  16. Transitional hemodynamics in infants of diabetic mothers by targeted neonatal echocardiography, electrocardiography and peripheral flow study.

    Science.gov (United States)

    Schierz, Ingrid Anne Mandy; Pinello, Giuseppa; Piro, Ettore; Giuffrè, Mario; La Placa, Simona; Corsello, Giovanni

    2017-05-05

    Metabolic alterations of intrauterine environment in diabetes mellitus (DM) lead to fetal cardiac dysfunctions that can persist after birth. The aim of the study was to assess the cardiovascular adaptation in infants born to diabetic mothers (IDM) with different degrees of glycometabolic control, in relation to revised guidelines for diagnosis of DM and quality improvements in neonatal care. An observational case-control study was conducted on IDM with gestational, type 1 and type 2 DM. Relevant maternal and neonatal anamnestic, clinical and laboratory data were analyzed. Electrocardiographic and echocardiographic analyses, including structural and systo-diastolic evaluation, were performed. In 68 IDM enrolled, we observed a lower incidence of negative perinatal outcome than expected. Comparing to non-IDM, they presented larger fetal shunts, higher pulmonary pressures, early and atrial wave velocities. At 72 hours, kinesis and heart rate variability remained low. Cerebral blood flow velocities were higher. The most serious impairment of transition was in pregestational IDM. Maternal DM impaired neonatal transitional hemodynamics also in asymptomatic IDM with good glycometabolic control. These results confirm the need for an early cardiologic and cerebrovascular evaluation, to identify IDM with delayed maturation at risk of worse long-term metabolic, cardiovascular, and neurodevelopmental outcome.

  17. Inhibition of Suicidal Erythrocyte Death by Indirubin-3'-Monoxime.

    Science.gov (United States)

    Liu, Chunqiu; Jiang, Peipei; Xu, Yuanhong; Zheng, Meijuan; Qiao, Jinpin; Zhou, Xueyong; Huang, Dake; Bian, Maohong

    2018-01-01

    Qing Dai is a prized traditional Chinese medicine whose major component, indirubin, and its derivative, indirubin-3'-monoxime (IDM), have inhibitory effects on the growth of many human tumor cells and pronounced anti-leukemic activities. However, the effects of IDM on mature human erythrocytes are unclear. This study aimed to evaluate the potential impact of IDM on erythrocytes and the mechanisms underlying that impact. Utilizing flow cytometry and confocal laser scanning microscopy, phosphatidylserine exposure at the cell surface was estimated by annexin V-fluorescein isothiocyanate (FITC). The relative cell size, expressed in arbitrary units, was evaluated by forward scatter in a flow cytometer. Fluo-3 fluorescence was used to bewrite changes in cytosolic Ca2+ activity, reactive oxygen species (ROS) formation was assessed by 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA) fluorescence, and ceramide abundance was evaluated by FITC-conjugated specific antibodies. The 24-h exposure of human erythrocytes to IDM (12 µM) significantly decreased the percentage of annexin V-binding erythrocytes and the intracellular calcium concentration ([Ca2+]i). IDM (3-12 µM) did not significantly modify the ceramide level or DCFH-DA fluorescence. Energy depletion (removal of glucose for 24 hours) significantly increased annexin V binding and Fluo-3 fluorescence and diminished forward scatter, and these effects were significantly mitigated by IDM (12 µM). Moreover, the Ca2+ ionophore ionomycin (1 µM, 60 min) and oxidative stress (30 min exposure to 0.05 mM tert-butyl hydroperoxide, t-BHP) similarly triggered eryptosis, which was also significantly suppressed by IDM. IDM is a novel inhibitor of suicidal erythrocyte death following ionomycin treatment, t-BHP treatment and energy depletion. Thus, IDM may counteract anemia and impairment of microcirculation, at least in part, by inhibition of Ca2+ entry into erythrocytes. © 2018 The Author(s). Published by S. Karger AG, Basel.

  18. Inhibition of Suicidal Erythrocyte Death by Indirubin-3’-Monoxime

    Directory of Open Access Journals (Sweden)

    Chunqiu Liu

    2018-02-01

    Full Text Available Background/Aims: Qing Dai is a prized traditional Chinese medicine whose major component, indirubin, and its derivative, indirubin-3’-monoxime (IDM, have inhibitory effects on the growth of many human tumor cells and pronounced anti-leukemic activities. However, the effects of IDM on mature human erythrocytes are unclear. This study aimed to evaluate the potential impact of IDM on erythrocytes and the mechanisms underlying that impact. Methods: Utilizing flow cytometry and confocal laser scanning microscopy, phosphatidylserine exposure at the cell surface was estimated by annexin V-fluorescein isothiocyanate (FITC. The relative cell size, expressed in arbitrary units, was evaluated by forward scatter in a flow cytometer. Fluo-3 fluorescence was used to bewrite changes in cytosolic Ca2+ activity, reactive oxygen species (ROS formation was assessed by 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA fluorescence, and ceramide abundance was evaluated by FITC-conjugated specific antibodies. Results: The 24-h exposure of human erythrocytes to IDM (12 µM significantly decreased the percentage of annexin V-binding erythrocytes and the intracellular calcium concentration ([Ca2+]i. IDM (3-12 µM did not significantly modify the ceramide level or DCFH-DA fluorescence. Energy depletion (removal of glucose for 24 hours significantly increased annexin V binding and Fluo-3 fluorescence and diminished forward scatter, and these effects were significantly mitigated by IDM (12 µM. Moreover, the Ca2+ ionophore ionomycin (1 µM, 60 min and oxidative stress (30 min exposure to 0.05 mM tert-butyl hydroperoxide, t-BHP similarly triggered eryptosis, which was also significantly suppressed by IDM. Conclusions: IDM is a novel inhibitor of suicidal erythrocyte death following ionomycin treatment, t-BHP treatment and energy depletion. Thus, IDM may counteract anemia and impairment of microcirculation, at least in part, by inhibition of Ca2+ entry into erythrocytes.

  19. A Prospective Study on the Influence of Scholastic Factors on the Prevalence and Initiation of Illicit Drug Misuse in Adolescence.

    Science.gov (United States)

    Zubak, Zoran; Zenic, Natasa; Ostojic, Ljerka; Zubak, Ivana; Pojskic, Haris

    2018-04-27

    This study aimed to prospectively investigate the scholastic factors related to illicit drug misuse (IDM) and the initiation of IDM among older adolescents from Bosnia and Herzegovina. This 2-year prospective study included 436 participants (202 females), who were an average of 16 years old at the beginning of the study (baseline). The participants were tested at baseline and follow-up (20 months later). The predictors included variables of scholastic-achievement (grade point average, school absences, unexcused absences and behavioral grade). The criteria were: (i) IDM at baseline; (ii) IDM at follow-up; and (iii) initiation of IDM over the study course. Results : Logistic regression indicated increased odds of IDM in adolescents who were more frequent absent from school (baseline: Odds Ratio (OR): 3.73, 95% Confidence Interval (CI): 2.12⁻6.57; follow-up: OR: 2.91, 95% CI: 1.90⁻4.65). The lower grade point average and more unexcused absences were evidenced for adolescents who consumed drugs on follow-up (OR: 1.67, 95% CI: 1.11⁻2.51; OR: 1.74, 95% CI: 1.30⁻2.32 for grade point average and unexcused absences, respectively). Initiation of IDM was predicted by frequent absences from school (OR: 2.2, 95% CI: 1.3⁻3.8), and lower behavioral grades (OR: 1.9, 95% CI: 1.2⁻3.3). The findings confirmed strong correlations between scholastic failure and IDM. Absences from school and lower behavioral grades at baseline were predictive of the initiation of IDM in older adolescents.

  20. Tchaikovsky, P.: Orchestral Suite no. 3 op. 55 / Terry Williams

    Index Scriptorium Estoniae

    Williams, Terry

    1996-01-01

    Uuest heliplaadist "Tchaikovsky, P.: Orchestral Suite no. 3 op. 55. Francesca di Rimini op. 32. Detroit Symphony Orchestra, Neeme Järvi". Chandos CHAN 9 419, distribution Media 7 (CD: 160F). TT: 1h 09'20"

  1. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2002-01-01

    Uutest plaatidest Craig David "Slicker Than Your Avarage", Whitney Houston "Just Whitney", Christina Aguilera "Stripped", Shaggy "Lucky Day", Tolga Kashif "The Queen Symphony", Mark Knopfler "Ragpicker's Dream", Soul Milita "On The Rise", Vello Orumets "Sõbrale"

  2. Lemba, Artur: Concerto for piano no. 1 in G / Guy S. Rickards

    Index Scriptorium Estoniae

    Rickards, Guy S.

    1998-01-01

    Uuest heliplaadist "Lemba, Artur: Concerto for piano no. 1 in G; Tubin, Eduard: Concertino forpiano and orchestra; Sumera, Lepo: Concerto for piano and orchestra. Lauri Väinmaa, piano, Estonian National Symphony Orchestra, Arvo Volmer". Finlandia 3984-20684-2

  3. Grieg: Songs and dramatic works with orchestra. / Alan Blyth

    Index Scriptorium Estoniae

    Blyth, Alan

    1993-01-01

    Uuest heliplaadist "Grieg: Songs and dramatic works with orchestra. Barbara Bonney, Randi Stene, Hakan Hagegard, Ruth Tellefsen, Gothenburg Symphony Chorus and Orchestra, Neeme Järvi." CD 437 519 - 2GH

  4. Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble / David J. Fanning

    Index Scriptorium Estoniae

    Fanning, David J.

    1991-01-01

    Uuest heliplaadist "Prokofiev: The Fiery Angel.Gösta Ohlin Vocal Ensemble, Gothenburg Pro Musica Chamber Choir and Symphony Orchestra, Neeme Järvi" DG CD 431 669-2 GH2 (two discs, nas:118 minutes:DDD)

  5. Shostakovich: Two Fables, Op. 4. Four Songs, Op. 46 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1994-01-01

    Uuest heliplaadist "Shostakovich: Two Fables, Op. 4. Four Songs, Op. 46. Songs on Verses by British Poets, Op. 140. From Jewish folk poetry, Op. 79. Gothenburg Symphony Orchestra / Neeme Järvi" DG CD 439860-2GH

  6. Bernstein: Prelude, Fugue and Riffs / Michel Parouty

    Index Scriptorium Estoniae

    Parouty, Michel

    1998-01-01

    Uuest heliplaadist "Bernstein: Prelude, Fugue and Riffs. Facsimile. West Side Story - Symphonic Dances. Divertimento. City of Birmingham Symphony Orchestra / Paavo Järvi" Virgin Classics VC5 45295-2 (68 minutes:DDD)

  7. Bernstein: Prelude, Fugue and Riffs / Edward Greenfield

    Index Scriptorium Estoniae

    Greenfield, Edward

    1998-01-01

    Uuest heliplaadist "Bernstein: Prelude, Fugue and Riffs. Facsimile. West Side Story - Symphonic Dances. Divertimento. City of Birmingham Symphony Orchestra / Paavo Järvi. Virgin Classics VC5 45295-2 (68 minutes:DDD)

  8. New Estonian CDs / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2001-01-01

    Uutest heliplaatidest "Eesti portreed", Lepo Sumera. Film Music by Lepo Sumera, Urmas Sisask "Starry Sky Cycle", "Poeme d'amour", "Tango King Astor Piazolla", "Eduard Tubin. Complete Symphonies vol. 2", Henn Rebane "Arabesque", Eino Tamberg "Nocturne"

  9. Pop / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2008-01-01

    Heliplaatidest: Supergrass "Diamond Hoo Ha", Man In Maardu "Solid Symphonies", Van Der Graaf Generator "Trisector", Bon Iver "For Emma, Forever Ago", The Last Shadow Puppets "The Age Of The Understatement", Brad Mehldau Trio "Live", Mariah Carey "E=MCø"

  10. Pop / Barbi Pilvre

    Index Scriptorium Estoniae

    Pilvre, Barbi, 1963-

    2007-01-01

    Heliplaatidest: Tokio Hotel "Zimmer 483", Air "Pocket Symphony", Mstrkrft "The Looks", Deerhoof "Friend Opportunity", 30 Seconds to Mars "A Beatiful Lie", Ferry "Dylanesque", Joss Stone "Introducing Joss Stone", Clint Mansell "The Fountain. Original soundtrack"

  11. Kuula. Pariisist Tokiosse, diivanilt tõusmata / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2007-01-01

    Heliplaatidest: Ozzy Osbourne "The Essential", Art Garfunkel "Some Enchanted Evening", Richard Galliano "Luz Negra", Music From Motion Picture "Dreamgirls", "Blue Note Trip Jazzanova", Mika "Life in Cartoon Motion". Prantsuse elektroonilise muusika ansamblist Air, heliplaadist "Pocket Symphony"

  12. Prokofiev: Sinfonia Concertante Op. 125 / Pierre-E. Barbier

    Index Scriptorium Estoniae

    Barbier, Pierre-E.

    1998-01-01

    Uuest heliplaadist "Prokofiev: Sinfonia Concertante Op. 125; Miaskowsky: Cello Concerto Op. 66, sellisti Truls Mörk ja City of Birmingham Symphony Orchestra, joht. Paavo Järvi" Virgin Classics 5 45282 2. (1988)

  13. Pilot scale processing of simulated Savannah River Site high level radioactive waste

    International Nuclear Information System (INIS)

    Hutson, N.D.; Zamecnik, J.R.; Ritter, J.A.; Carter, J.T.

    1991-01-01

    The Savannah River Laboratory operates the Integrated DWPF Melter System (IDMS), which is a pilot-scale test facility used in support of the start-up and operation of the US Department of Energy's Defense Waste Processing Facility (DWPF). Specifically, the IDMS is used in the evaluation of the DWPF melter and its associated feed preparation and offgass treatment systems. This article provides a general overview of some of the test work which has been conducted in the IDMS facility. The chemistry associated with the chemical treatment of the sludge (via formic acid adjustment) is discussed. Operating experiences with simulated sludge containing high levels of nitrite, mercury, and noble metals are summarized

  14. Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising.

    Science.gov (United States)

    Golla, Sandeep S V; Lubberink, Mark; van Berckel, Bart N M; Lammertsma, Adriaan A; Boellaard, Ronald

    2017-12-01

    Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have been proposed as a means to correct for PVE. IDM improves spatial resolution of PET studies without the need for structural information (e.g. MR scans). On the other hand, deconvolution also increases noise, which results in lower signal-to-noise ratios (SNR). The aim of this study was to implement IDM in combination with HighlY constrained back-PRojection (HYPR) denoising to mitigate poor SNR properties of conventional IDM. An anthropomorphic Hoffman brain phantom was filled with an [ 18 F]FDG solution of ~25 kBq mL -1 and scanned for 30 min on a Philips Ingenuity TF PET/CT scanner (Philips, Cleveland, USA) using a dynamic brain protocol with various frame durations ranging from 10 to 300 s. Van Cittert IDM was used for PVC of the scans. In addition, HYPR was used to improve SNR of the dynamic PET images, applying it both before and/or after IDM. The Hoffman phantom dataset was used to optimise IDM parameters (number of iterations, type of algorithm, with/without HYPR) and the order of HYPR implementation based on the best average agreement of measured and actual activity concentrations in the regions. Next, dynamic [ 11 C]flumazenil (five healthy subjects) and [ 11 C]PIB (four healthy subjects and four patients with Alzheimer's disease) scans were used to assess the impact of IDM with and without HYPR on plasma input-derived distribution volumes (V T ) across various regions of the brain. In the case of [ 11 C]flumazenil scans, Hypr-IDM-Hypr showed an increase of 5 to 20% in the regional V T whereas a 0 to 10% increase or decrease was seen in the case of [ 11 C]PIB depending on the volume of interest or type of subject (healthy or patient). References for these comparisons were the V T s from the PVE-uncorrected scans. IDM improved quantitative accuracy

  15. Interacting dark matter and dark radiation

    Science.gov (United States)

    Tang, Yong

    2017-05-01

    We give a brief review on the interacting Dark Matter (iDM) scenario and its effects on cosmology and particle physics. If DM candidates can have strong self-interactions or interactions with other relativistic particles, we can refer them generally as iDM. IDM is an interesting possibility that is motivated both theoretically and observationally. The relativistic particles could belong to Standard Model (SM), such as photons and neutrinos, or be dark radiation (DR) in new physics. The resulting perturbed Boltzmann equations are concisely discussed and illustrations on matter power spectrum are given.

  16. Pulsed ion hall accelerator for investigation of reactions between light nuclei in the astrophysical energy range

    Science.gov (United States)

    Bystritsky, V. M.; Bystritsky, Vit. M.; Dudkin, G. N.; Nechaev, B. A.; Padalko, V. N.

    2017-07-01

    The factors defining the constraints on the current characteristics of the magnetically insulated ion diode (IDM) are considered. The specific current parameters close to the maximum possible ones are obtained for the particular IDM-40 design assigned for acceleration of light ions and investigation of nuclear reactions with small cross sections in the astrophysical energy range (2-40 keV) in the entrance channel. It is experimentally demonstrated that the chosen optimal operation conditions for IDM-40 units provide high stability of the parameters (energy distribution and composition of accelerated particle beams, degree of neutralization) of the accelerated particle flux, which increases during the working pulse.

  17. Process and building information modelling in the construction industry by using information delivery manuals and model view definitions

    DEFF Research Database (Denmark)

    Karlshøj, Jan

    2012-01-01

    of information and specifying exactly which objects and properties are needed for each process and which information is produced by the processes. The present study is based on reviewing the existing methodology of Information Delivery Manuals (IDM) from Buildingsmart, which also is also an ISO standard 29481....... The project-based approach is an obstacle to standardized processes and exchange requirements, which are vital elements in the methodology of making IDMs. Several of the proposed IDMs have been developed or sponsored by public clients that have a long-term perspective and the ability to push implementation...

  18. A Case for Implementation of Citizen Centric National Identity Management Systems

    DEFF Research Database (Denmark)

    Adjei, Joseph K.

    systems (IdMS) has largely focused on the stringent security requirements rather than the needs of the citizens, and there is a need for designing and developing systems that are user-centric and privacy enhancing. Many of the proposed solutions implicitly assume easy Internet access, user awareness...... of national IdMS, using a qualitative case study research approach. Empirical data were gathered in Ghana through a combination of quasi-statistical survey and problem structuring methodology. The study shows that effective IdMS depend on efficient civil registration systems, user involvement...

  19. Centaure: an heterogeneous parallel architecture for computer vision

    International Nuclear Information System (INIS)

    Peythieux, Marc

    1997-01-01

    This dissertation deals with the architecture of parallel computers dedicated to computer vision. In the first chapter, the problem to be solved is presented, as well as the architecture of the Sympati and Symphonie computers, on which this work is based. The second chapter is about the state of the art of computers and integrated processors that can execute computer vision and image processing codes. The third chapter contains a description of the architecture of Centaure. It has an heterogeneous structure: it is composed of a multiprocessor system based on Analog Devices ADSP21060 Sharc digital signal processor, and of a set of Symphonie computers working in a multi-SIMD fashion. Centaure also has a modular structure. Its basic node is composed of one Symphonie computer, tightly coupled to a Sharc thanks to a dual ported memory. The nodes of Centaure are linked together by the Sharc communication links. The last chapter deals with a performance validation of Centaure. The execution times on Symphonie and on Centaure of a benchmark which is typical of industrial vision, are presented and compared. In the first place, these results show that the basic node of Centaure allows a faster execution than Symphonie, and that increasing the size of the tested computer leads to a better speed-up with Centaure than with Symphonie. In the second place, these results validate the choice of running the low level structure of Centaure in a multi- SIMD fashion. (author) [fr

  20. Vom Klangrausch des Nordwinds und der leeren Tafel der Seele. Lepo Sumeras vierte Symphonie "Serena Borealis" in Karlsruhe uraufgeführt: Eri Klas dirigierte im Konzert der Badischen Staatskapelle zu den Kulturtagen auch Musik von Arvo Pärt und Edua

    Index Scriptorium Estoniae

    Hartmann, Ulrich

    1992-01-01

    Lepo Sumera neljanda sümfoonia "Serena Borealis" esiettekanne Karlsruhes: Eri Klas dirigeeris kontserdil kultuuripäevade raames ka Arvo Pärdi ja Eduard Tubina muusikat. Eesti muusikute esinemisest Karlsruhe kultuuripäevadel

  1. Process and building information modelling in the construction industry by using information delivery manuals and model view definitions

    DEFF Research Database (Denmark)

    Karlshøj, Jan

    2012-01-01

    of information and specifying exactly which objects and properties are needed for each process and which information is produced by the processes. The present study is based on reviewing the existing methodology of Information Delivery Manuals (IDM) from Buildingsmart, which also is also an ISO standard 29481....... The project-based approach is an obstacle to standardized processes and exchange requirements, which are vital elements in the methodology of making IDMs. Several of the proposed IDMs have been developed or sponsored by public clients that have a long-term perspective and the ability to push implementation...... of countries, it has also noted that it can be difficult to finalize IDM and make the necessary changes in the relevant software products, change existing processes, and develop a data validation system that verifies that the data delivered is according to the specifications. Based on experiences from...

  2. Intranet Document Management Systems.

    Science.gov (United States)

    Wen, H. Joseph; Yen, David C.; Lin, Binshan

    1998-01-01

    Explains how intranets facilitate documentation availability within a company at substantial cost savings. Topics include intranet document management systems (IDMS); publication costs for printed materials; hardware and software specifications; performance; and security. (Author/LRW)

  3. Hot vacuum extraction-isotopic dilution mass spectrometry for determination of hydrogen isotopes in zircaloys

    International Nuclear Information System (INIS)

    Shi, Y.; Leeson, P.K.; Wilkin, D.; Britton, A.; Macleod, R.

    2016-01-01

    A hot vacuum extraction-isotope dilution mass spectrometry (HVE-IDMS) was studied for determination of hydrogen isotopes in zirconium metal and alloys as nuclear reactor materials. A theoretical assessment of the completeness of the extraction of hydrogen isotopes under the chosen condition was carried out based on the hydrogen and deuterium solubility data for zirconium. The optimal isotopic spiking condition for conventional IDMS was further explored for the special case IDMS where the isotope abundance of the samples is varied and non-natural. Applying the optimal conditions, the accurate IDMS determination was realized. The agreement between the measured values and the certified or prepared values of standard reference materials and homemade standard materials validate the method developed. (author)

  4. Electrosprayed inulin microparticles for microbiota triggered targeting of colon.

    Science.gov (United States)

    Jain, Arvind K; Sood, Vishesh; Bora, Meghali; Vasita, Rajesh; Katti, Dhirendra S

    2014-11-04

    Inulin, a naturally occurring polysaccharide, was acetylated to make it processable by electrospraying, a facile and single step method for microparticle fabrication. Electrospraying process parameters were optimized for fabrication of spherical and monodisperse indomethacin (IDM) loaded inulin acetate (INA) microparticles. The apparent entrapment efficiency of IDM was determined to be 100%, whereas working encapsulation efficiency was estimated to be 35.39 ± 1.63%. Differential scanning calorimetry and X-ray diffraction analysis confirmed molecular dispersion of IDM in an amorphous state within the INA matrix. Finally, the results from in vitro release study performed in simulated gastro-intestinal fluids demonstrated that IDM was released only in simulated colonic fluid that contained inulinase. Therefore, this study demonstrates that acetylation of inulin does not alter its susceptibility to inulinase and that microparticles fabricated from INA can be developed as a colon targeting drug delivery system. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Exploring an informed decision-making framework using in-home sensors: older adults' perceptions.

    Science.gov (United States)

    Chung, Jane; Reeder, Blaine; Lazar, Amanda; Joe, Jonathan; Demiris, George; Thompson, Hilaire J

    2014-01-01

    Sensor technologies are designed to assist independent living of older adults. However, it is often difficult for older adults to make an informed decision about adopting sensor technologies. To explore Bruce's framework of informed decision making (IDM) for in-home use of sensor technologies in community-dwelling elders. The IDM framework guided development of a semi-structured interview. A theory-driven coding approach was used for analysis. Participants supported most of the elements of the framework, but not all aspects of each element were addressed. Perceived usefulness of technologies was identified as an area for framework extension. This paper provides useful information for health care professionals to consider how to enhance IDM of older adults regarding the use of sensor technologies. The results also illuminate elements of the IDM framework that may be critical to facilitating independent living for older adults.

  6. The electroweak phase transition in the Inert Doublet Model

    Energy Technology Data Exchange (ETDEWEB)

    Blinov, Nikita [Department of Physics, University of California Santa Cruz,1156 High St, Santa Cruz, CA 95064 (United States); Santa Cruz Institute for Particle Physics,1156 High St, Santa Cruz, CA 95064 (United States); Theory Department, TRIUMF,4004 Wesbrook Mall, Vancouver, BC V6T 2A3 (Canada); Department of Physics and Astronomy, University of British Columbia,Vancouver, BC V6T 1Z1 (Canada); Profumo, Stefano; Stefaniak, Tim [Department of Physics, University of California Santa Cruz,1156 High St, Santa Cruz, CA 95064 (United States); Santa Cruz Institute for Particle Physics,1156 High St, Santa Cruz, CA 95064 (United States)

    2015-07-21

    We study the strength of a first-order electroweak phase transition in the Inert Doublet Model (IDM), where particle dark matter (DM) is comprised of the lightest neutral inert Higgs boson. We improve over previous studies in the description and treatment of the finite-temperature effective potential and of the electroweak phase transition. We focus on a set of benchmark models inspired by the key mechanisms in the IDM leading to a viable dark matter particle candidate, and illustrate how to enhance the strength of the electroweak phase transition by adjusting the masses of the yet undiscovered IDM Higgs states. We argue that across a variety of DM masses, obtaining a strong enough first-order phase transition is a generic possibility in the IDM. We find that due to direct dark matter searches and collider constraints, a sufficiently strong transition and a thermal relic density matching the universal DM abundance is possible only in the Higgs funnel regime.

  7. The electroweak phase transition in the Inert Doublet Model

    Energy Technology Data Exchange (ETDEWEB)

    Blinov, Nikita; Profumo, Stefano; Stefaniak, Tim, E-mail: nblinov@triumf.ca, E-mail: profumo@ucsc.edu, E-mail: tistefan@ucsc.edu [Department of Physics, University of California Santa Cruz, 1156 High St, Santa Cruz, CA 95064 (United States)

    2015-07-01

    We study the strength of a first-order electroweak phase transition in the Inert Doublet Model (IDM), where particle dark matter (DM) is comprised of the lightest neutral inert Higgs boson. We improve over previous studies in the description and treatment of the finite-temperature effective potential and of the electroweak phase transition. We focus on a set of benchmark models inspired by the key mechanisms in the IDM leading to a viable dark matter particle candidate, and illustrate how to enhance the strength of the electroweak phase transition by adjusting the masses of the yet undiscovered IDM Higgs states. We argue that across a variety of DM masses, obtaining a strong enough first-order phase transition is a generic possibility in the IDM. We find that due to direct dark matter searches and collider constraints, a sufficiently strong transition and a thermal relic density matching the universal DM abundance is possible only in the Higgs funnel regime.

  8. An Effective Method on Applying Feedback Error Learning Scheme to Functional Electrical Stimulation Controller

    Science.gov (United States)

    Watanabe, Takashi; Kurosawa, Kenji; Yoshizawa, Makoto

    A Feedback Error Learning (FEL) scheme was found to be applicable to joint angle control by Functional Electrical Stimulation (FES) in our previous study. However, the FEL-FES controller had a problem in learning of the inverse dynamics model (IDM) in some cases. In this paper, methods of applying the FEL to FES control were examined in controlling 1-DOF movement of the wrist joint stimulating 2 muscles through computer simulation under several control conditions with several subject models. The problems in applying FEL to FES controller were suggested to be in restricting stimulation intensity to positive values between the minimum and the maximum intensities and in the case of very small output values of the IDM. Learning of the IDM was greatly improved by considering the IDM output range with setting the minimum ANN output value in calculating ANN connection weight change.

  9. Het inbedden van BIM. In interactiekaders en objectbibliotheken

    NARCIS (Netherlands)

    Willems, P.H.; Böhms, M.

    2012-01-01

    Een bouwwerkinformatiemodel (BIM) zelf lost de tekortkomingen van ICTondersteuning in de bouwproductieketen niet adequaat op. Een BIM zou moeten worden ingebed in een formele beschrijving van alle benodigde uitwisselingsvereisten. De ISO/buildingSMART standaard Information Delivery Manual (IDM) is

  10. Differences in virulence of pneumolysin and autolysin mutants constructed by insertion duplication mutagenesis and in-frame deletion in Streptococcus pneumoniae.

    Science.gov (United States)

    Liu, Esther Yip-Mei; Chang, Feng-Yee; Chang, Jen-Chang; Fung, Chang-Phone

    2014-02-21

    Insertion duplication mutagenesis (IDM) and in-frame deletion (IFD) are common techniques for studying gene function, and have been applied to pneumolysin (ply), a virulence gene in Streptococcus pneumoniae (D39). Discrepancies in virulence between the two techniques were observed in both the previous and present studies. This phenomenon was also observed during mutation analysis of autolysin (lytA). Our data showed that target gene restoration (TGR) occurred in IDM mutants, even in the presence of antibiotics, while the IFD mutants were stable. In PCR result, TGR occurred later in IDM-ply and -lytA mutants cultured in non-supplemented medium (4-5 h) compared with those grown in medium supplemented with erythromycin (erm)/chloramphenicol (cat) (3-4 h), but plateaued faster. Real-time PCR for detecting TGR had been performed. When compared with 8-h culture, TGR detection increased from Day 1 and Day 2 of IDM mutant's culture. erm-sensitive clones from IDM mutant were found. Southern blot hybridization and Western blotting also confirmed the phenomenon of TGR. The median survival of mice following intraperitoneal (IP) injection with a 3-h culture of IDM-mutants was significantly longer than that with an 8-h culture, irrespective of antibiotic usage. The median survival time of mice following IP injection of a 3-h culture versus an 8-h culture of IDM-ply in the absence of antibiotics was 10 days versus 2 days (p = 0.031), respectively, while in the presence of erm, the median survival was 5 days versus 2.5 days (p = 0.037), respectively. For an IDM-lytA mutant, the corresponding values were 8.5 days versus 2 days (p = 0.019), respectively, for non-supplemented medium, and 2.5 versus 2 days (p = 0.021), respectively, in the presence of cat. A comparable survival rate was observed between WT D39 and an 8-h IDM culture. TGR in IDM mutants should be monitored to avoid inconsistent results, and misinterpretation of data due to TGR could lead to

  11. Influence of pH and method of crystallization on the solid physical form of indomethacin.

    Science.gov (United States)

    Dubbini, Alessandra; Censi, Roberta; Martena, Valentina; Hoti, Ela; Ricciutelli, Massimo; Malaj, Ledjan; Di Martino, Piera

    2014-10-01

    The purpose of this study was to investigate the effect of pH and method of crystallization on the solid physical form of indomethacin (IDM). IDM, a non steroidal anti-inflammatory drug poorly soluble in water, underwent two different crystallization methods: crystallization by solvent evaporation under reduced pressure at 50.0°C (method A), and crystallization by cooling of solution from 50.0 to 5.0°C (method B). In both cases, several aqueous ethanolic solutions of IDM of different pHs were prepared. pHs were adjusted by adding acidic solutions (HCl 2M) or alkali (NaOH or NH4OH 2M) to an aqueous ethanolic solution of IDM. Thus, several batches were recovered after crystallization. The chemical stability of IDM was verified through (1)H NMR and mass spectroscopy (FIA-ESI-MS), that revealed that IDM degraded in strong alkali media (pH ≥ 12). Crystals obtained under different crystallization conditions at pHs of 1.0, 4.5, 7.0, 8.0, 10.0 and chemically stable were thus characterized for crystal habit by scanning electron microscopy, for thermal behaviour by differential scanning calorimetry, and thermogravimetry, and for solid state by X-ray powder diffractometry. Under the Method A, IDM always crystallized into pure metastable alpha form when solutions were acidified or alkalized respectively with HCl and NH4OH. On the contrary, in presence of NaOH, IDM crystallized under a mixture of alpha and sodium trihydrate form, because the presence of the sodium counter ion orientates the crystallization towards the formation of the trihydrate salt. Under the method B, at pH of 1.0, IDM crystallized under the alpha form; at pH 4.5, IDM crystallized under the form alpha in presence of some nuclei of gamma form; at pH 7.0, 8.0, and 10.0 for NH4OH, IDM crystallized under the most stable polymorph gamma form, whereas in presence of NaOH, a mix of alpha, and salt forms was formed whatever the pH of the solution. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. COMBINE 2 seminar

    DEFF Research Database (Denmark)

    Sørensen, Lars Schiøtt; Jacobsen, Kim

    1995-01-01

    A seminar about the COMBINE project was described. Further, the project was described in generel, i.e. the COMBINE´s data model (IDM), the data exchange system (DES) and the different I/O-systems included in COMBINE 2......A seminar about the COMBINE project was described. Further, the project was described in generel, i.e. the COMBINE´s data model (IDM), the data exchange system (DES) and the different I/O-systems included in COMBINE 2...

  13. Umbilical artery intima-media and wall thickness in infants of diabetic mothers.

    Science.gov (United States)

    Sarikabadayi, Yusuf Unal; Aydemir, Ozge; Kanmaz, Gozde; Aydemir, Cumhur; Oguz, Serife Suna; Erdeve, Omer; Eyi, Elif Gul Yapar; Zergeroglu, Sema; Dilmen, Ugur

    2012-01-01

    Large for gestational age (LAG) neonates who had been exposed to an intrauterine environment of either diabetes or maternal obesity are at increased risk of developing the metabolic syndrome. This can be explained by exposure to high glucose and insulin levels in utero which alter fetal adaptation and programming. The aim of the study was to evaluate the onset of preclinical atherosclerosis in utero. We measured umbilical artery wall thickness (ruWT) in the third trimester by obstetric ultrasound and umbilical artery intima-media thickness (uIMT) in pathologic specimens of umbilical cords obtained shortly after delivery and investigated the relation between these measurements and serum insulin level and C-peptide level in cord blood and assessed insulin resistance with the homeostasis model assessment of insulin resistance (HOMA-IR) in infants of diabetic mothers (IDMs), i.e. the study group, which was divided into a large for gestational age group (LGA)-IDM group and an appropriate for gestational age group (AGA)-IDM group and compared with a control group. The LGA-IDM group had significantly higher insulin (p IDM and control groups. The LGA-IDM group had significantly larger ruWT (p = 0.013) and uIMT (p IDM and the control groups. The LGA-IDM group had increased uIMT and ruWT that correlated with the severity of maternal hyperglycemia. Measurement of ruWT in the third trimester is feasible, reproducible and strongly correlated with pathological serum insulin, C-peptide in cord blood and HOMA-IR levels. Copyright © 2012 S. Karger AG, Basel.

  14. Current federal identity management and the dynamic signature biometrics option

    OpenAIRE

    Zanger, Michael S.

    2009-01-01

    Approved for public release, distribution unlimited Although Identity Management (IdM) and biometrics have been engrained in the business practices of private and commercial organizations for decades, the United States Government (USG) and the Department of Defense (DoD) have only truly started to institute a holistic IdM Enterprise within the last decade. More specifically, the DoD has really sharpened the focus on leveraging biometrics since the beginning of the War on Terror. The o...

  15. Intracranial dural metastases.

    Science.gov (United States)

    Nayak, Lakshmi; Abrey, Lauren E; Iwamoto, Fabio M

    2009-05-01

    : Intracranial dural metastases (IDM) are found at autopsy in 9% of patients with advanced systemic cancer. However, to the authors' knowledge, IDM have not been studied systematically in the modern neuroimaging era. The objective of the current study was to evaluate the demographics, clinical presentation, imaging, treatment, and prognosis of patients with IDM. : The current study was a retrospective review of 122 patients with IDM diagnosed at Memorial Sloan-Kettering Cancer Center between 1999 and 2006. Patients with concurrent brain or leptomeningeal metastases were excluded. : Sixty-one percent of the patients were women; the median age at diagnosis was 59 years, the median Karnofsky performance scale (KPS) at diagnosis was 80, and the median time to IDM diagnosis from initial cancer diagnosis was 37 months. Breast (34%) and prostate (17%) cancers were the most frequent primary tumors associated with IDM. Fifty-six percent of patients had a single dural metastasis. On imaging, 70% had metastases of the overlying skull, 44% had dural tail metastases, 53% had vasogenic edema, and 34% had brain invasion. Direct extension from skull metastases was the most common mode of spread. Eighty-three percent of patients had active systemic disease at the time of IDM diagnosis. A lower KPS and lung cancer were associated with worse overall survival. Surgical resection and chemotherapy improved progression-free survival, but only resection was found to be associated with improved overall survival. : IDM affect a significant proportion of cancer patients. KPS and status of systemic cancer should guide treatment decisions. Cancer 2009. (c) 2009 American Cancer Society.

  16. Physician behaviors to promote informed decisions for prostate cancer screening: a National Research Network study.

    Science.gov (United States)

    Linder, Suzanne K; Kallen, Michael A; Mullen, Patricia Dolan; Galliher, James M; Swank, Paul R; Chan, Evelyn C Y; Volk, Robert J

    2014-06-01

    Clinical guidelines for prostate cancer screening (PCS) advise physicians to discuss the potential harms and benefits of screening. However, there is a lack of training programs for informed decision-making (IDM), and it is unknown which IDM behaviors physicians have the most difficulty performing. Identifying difficult behaviors can help tailor training programs. In the context of developing a physician-IDM program for PCS, we aimed to describe physicians' use of nine key IDM behaviors for the PCS discussion and to examine the relation between the behaviors and physician characteristics. A cross-sectional sample of The American Academy of Family Physicians National Research Network completed surveys about their behavior regarding PCS (N = 246; response rate = 58%). The surveys included nine physician key IDM behaviors for PCS and a single-item question describing their general practice style for PCS. The most common IDM behavior was to invite men to ask questions. The two least common reported behaviors concerned patients uncertain about screening (i.e., arrange follow-up and provide additional information for undecided men). Physicians reported difficulty with these two behaviors regardless whether they reported to discuss or not to discuss PCS with patients. Reported use of key IDM behaviors was associated with a general practice style for PCS and being affiliated with a residency-training program. Physician training programs for IDM should include physician skills to address the needs of patients uncertain about screening. Future research should determine if actual behavior is associated with self-reported behavior for the PCS discussion.

  17. Introducing a new framework for using generic Information Delivery Manuals

    OpenAIRE

    Mondrup, Thomas Fænø; Treldal, Niels; Karlshøj, Jan; Vestergaard, Flemming

    2014-01-01

    Information flow management plays a significant role in ensuring the reliable exchange of Building Information Modeling (BIM) information between project participants in the Architecture, Engineer-ing, Construction, and Facility Management (AEC/FM) industry. The buildingSMART standard approach to resolve this issue is based on the Information Delivery Manual (IDM). The IDMs in current use indicate that focus has mainly been on formalizing multifaceted and wide-ranging AEC/FM processes, and th...

  18. A computationally efficient model to capture the inertia of the piezoelectric stack in impact drive mechanism in the case of the in-pipe inspection application

    Directory of Open Access Journals (Sweden)

    J. Li

    2016-03-01

    Full Text Available This paper presents a new model for the piezoelectric actuator (PA in the context of in the impact drive mechanism (IDM for the in-pipe inspection application. The feature of the model is capturing the inertia of PA stack in a distributed manner as opposed to the lumped manner in literature. The benefit arising from this feature is a balanced trade-off between computational efficiency and model accuracy. The study presented in this paper included both theoretical development (i.e. the model of the piezoelectric actuator and the model of the entire IDM which includes the actuator and experimental verification of the model. The study has shown that (1 the inertia of the PA in such a robot will significantly affect the accuracy of the entire model of IDM and (2 the simulation of the dynamic behavior with the proposed model is sufficiently accurate by comparing with the experiment. It is thus recommended that the inertia of the PA be considered in the entire model of the IDM robot. The model is an analytical type, which has a high potential to be used for the model-based control of the IDM robot and optimization of its design for a much improved performance of the IDM system.

  19. Status of the inert doublet model and the role of multileptons at the LHC

    Science.gov (United States)

    Gustafsson, Michael; Rydbeck, Sara; Lopez-Honorez, Laura; Lundström, Erik

    2012-10-01

    A feature of the inert doublet model (IDM) is to provide a dark matter candidate together with an alteration of both direct and indirect collider constraints that allow for a heavy Higgs boson. We study the IDM in light of recent results from Higgs searches at the Large Hadron Collider (LHC) in combination with dark matter direct detection limits from the XENON experiment. We ask under what conditions the IDM can still accommodate a heavy Higgs boson. We find that IDM scenarios with a Higgs boson in the mass range 160-600 GeV are ruled out only when all experimental constraints are combined. For models explaining only a fraction of the dark matter the limits are weakened, and IDMs with a heavy Higgs are allowed. We discuss the prospects for future detection of such IDM scenarios in the four-lepton plus missing energy channel at the LHC. This signal can show up in the first year of running at s=14TeV, and we present detector-level studies for a few benchmark models.

  20. [Synthesis of colon-specific prodrug of indomethacin and its inhibitory effect on liver metastasis from colon cancer].

    Science.gov (United States)

    Peng, Ning-fu; Yang, Li-qun; Chen, Ru-fu; Cai, Xiang; Li, Le-qun; Li, Zhi-hua; Zhou, Quan-bo; Zhou, Jia-jia; Jiang, Zhi-peng

    2010-03-01

    To develop a colon-specific prodrug of Indomethacin microbially triggered, carry out in vitro/in vivo evaluation of drug release, and appraise its inhibitory effect on liver metastasis from colon cancer. Indomethacin prodrugs were synthesized and characterized by FTIR and NMR, and dissolution test simulating gastrointestinal tract was employed to screen the colon-specific prodrug. Then, the pharmacokinetic profile of portal vein and peripheral blood in Sprague-Dawley rats was studied. Lastly, the inhibitory effect on liver metastasis from colon cancer in nude mice was observed. The chemical structure characterized by FTIR and NMR demonstrated that six kinds of indomethacin-block-amylose with different drug loading (IDM-AM-1-6) were synthesized, among which IDM-AM-3 was degraded 1.3%, 9.3% and 95.3%, respectively, in simulated gastric fluid for 4 h, small intestine for 6 h, and colon for 36 h. The pharmacokinetic test of IDM-AM-3 showed that absorption was delayed significantly (P IDM regarding to portal vein. Additionally, its AUC(0-t) in peripheral blood was remarkably lower than that in Portal vein (P IDM (P IDM-AM-3 possesses advantage of sustained release in portal vein providing some experimental basis for colon-specific delivery system applied to sustained release in the portal vein.

  1. An optimized protocol for the production of interdelta markers in Saccharomyces cerevisiae by using capillary electrophoresis.

    Science.gov (United States)

    Tristezza, Mariana; Gerardi, Carmela; Logrieco, Antonio; Grieco, Francesco

    2009-09-01

    The amplification of genomic sequence blocks flanked by delta elements of retrotransposon origin has proved to be a very convenient method for molecular characterization of Saccharomyces cerevisiae strains. Fluorescent automated capillary electrophoresis (CE) was used to detect interdelta marker (IDM) patterns in S. cerevisiae, using the ABI Prism 3130 Genetic Analyzer. Main experimental parameters were studied and the optimal conditions for IDM amplification and samples run on the CE apparatus were determined. Fingerprints from fluorescent-labelled IDM produced using CE with the same sample analyzed by agarose electrophoresis (AE) were compared. The CE analysis was able to distinguish 43 different IDM profiles among 45 S. cerevisiae isolates with a discriminating capacity of 99.8%, whereas the AE analysis of the same samples allowed the identification of 27 different patterns (discriminatory power equal to 96%). Detection of fluorescent IDM was fast and reliable, and it facilitated data comparison. For the first time in our knowledge, the fluorescent CE proved to be well suited for IDM fingerprinting. Moreover, it could be routinely applied for the molecular differentiation of S. cerevisiae strains.

  2. Audit of a clinical guideline for neonatal hypoglycaemia screening.

    Science.gov (United States)

    Sundercombe, Samantha L; Raynes-Greenow, Camille H; Carberry, Angela E; Turner, Robin M; Jeffery, Heather E

    2013-10-01

    This study aims to evaluate adherence to a clinical guideline for screening and prevention of neonatal hypoglycaemia on the post-natal wards. Retrospective chart review of 581 healthy term neonates born at a tertiary maternity hospital. Indications for hypoglycaemia screening included small for gestational age (SGA), infants of diabetic mothers (IDM; gestational, Type 1 or 2), symptomatic hypoglycaemia, macrosomia and wasted (undernourished) appearance. Outcomes were protocol entry and adherence with hypoglycaemia prevention strategies including early and frequent feeding and timely blood glucose measurement. Of 115 neonates screened for hypoglycaemia, 67 were IDM, 19 were SGA (including two both IDM and SGA), and two were macrosomic. One IDM and one SGA were not screened. Twenty-two neonates were screened for a reason not identifiable from the medical record, and 13 neonates were SGA by a definition different to the guideline definition, including five who were also IDM. Guideline adherence was variable. Few neonates (41 of 106, 39%) were fed in the first post-natal hour, and blood glucose measurement occurred later than recommended for 41 of 106 (39%) of neonates. Most IDM and SGA neonates were screened. While guideline adherence overall was comparable with other studies, neonates were fed late. We recommend staff education about benefits of early (within the first hour) frequent breastfeeding for neonates at risk. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  3. Impact of maternal diabetes mellitus on mortality and morbidity of preterm infants (24-33 weeks' gestation).

    Science.gov (United States)

    Bental, Yoram; Reichman, Brian; Shiff, Yakov; Weisbrod, Meir; Boyko, Valentina; Lerner-Geva, Liat; Mimouni, Francis B

    2011-10-01

    We hypothesized that maternal diabetes mellitus (DM) increases the risk for mortality, respiratory distress syndrome (RDS), and major complications of prematurity. Analysis of prospectively collected (1995-2007) Israel National Very Low Birth Weight Infant Database. Maternal DM was recorded as pregestational or gestational. Multivariable logistic regression analysis was used to assess the independent effect of maternal DM status on infant mortality, RDS, and other complications of prematurity. Infants of mothers with pregestational (n = 120) and gestational (n = 825) DM were similar, and their data were pooled for analyses. Mothers with DM were more likely to have received a complete course of prenatal steroids than control mothers. Infants of diabetic mothers (IDM) had a slightly higher gestational age and birthweight than non-IDM's. Distribution of birthweight percentiles and the mean birthweight z scores were similar. Apgar scores were statistically higher in the IDM group. There were no significant differences between the 2 groups in terms of delivery room mortality, RDS, and other major complications of prematurity. Total mortality and bronchopulmonary dysplasia rates were significantly higher in the nondiabetic group. The adjusted odds ratios for mortality, RDS, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, necrotizing enterocolitis, and patent ductus arteriosus were not significantly increased in the IDM group. With modern management and adequate prenatal care, IDM born very low birthweight do not seem to be at an excess risk of developing RDS or other major complications of prematurity compared with non-IDM.

  4. Video-EEG recordings in full-term neonates of diabetic mothers: observational study.

    Science.gov (United States)

    Castro Conde, José Ramón; González González, Nieves Luisa; González Barrios, Desiré; González Campo, Candelaria; Suárez Hernández, Yaiza; Sosa Comino, Elena

    2013-11-01

    To determine whether full-term newborn infants of diabetic mothers (IDM) present immature/disorganised EEG patterns in the immediate neonatal period, and whether there was any relationship with maternal glycaemic control. Cohort study with an incidental sample performed in a tertiary hospital neonatal unit. 23 IDM and 22 healthy newborns born between 2010 and 2013. All underwent video-EEG recording lasting >90 min at 48-72 h of life. We analysed the percentage of indeterminate sleep, transient sharp waves per hour and mature-for-gestational age EEG patterns (discontinuity, maximum duration of interburst interval (IBI), asynchrony, asymmetry, δ brushes, encoches frontales and α/θ rolandic activity). The group of IDM was divided into two subgroups according to maternal HbA1c: (1) HbA1c≥6% and (2) HbA1cIDM presented significantly higher percentage of indeterminate sleep (57% vs 25%; pIDM with maternal HbA1c≥6% showed greater percentage of δ brushes in the burst (14% vs 4%; p=0.007). Full-term IDM newborns showed video-EEG features of abnormal development of brain function. Maternal HbA1c levels<6% during pregnancy could minimise the risk of cerebral dysmaturity.

  5. Measurement of linear polymerization shrinkage in light cure Ideal Makoo composite resin

    Directory of Open Access Journals (Sweden)

    Ghavam M.

    2001-09-01

    Full Text Available "nAbstract: Polymerization shrinkage of light cure composite resins causes many complications in conservative and esthetic restorations. The objective of this in-vitro study was to evaluate the polymerization shrinkage, degree of conversion and the amount of filler in IDM and tetric ceram composites. Ten disk shaped, uncured specimens (8mm×1.547mm of each composite were placed on glass slide in the center of the metal attached to it. Then specimens were light cured for 60s from underneath. After 30 minutes, the thickness of specimens, using a micrometer and the percent of the polymerization shrinkage of each sample were measured. Statistical analysis was carried out by t-test (P<0.05. Also the degree of conversion of specimens was evaluated with FTIR and the mineral filler content was measured by burning in electric oven. Polymerization shrinkage in IDM and tetric ceram was not significantly different. Degree of conversion and mineral filler content in tetric ceram was greater than that of IDM. "nIt is assumed that the low degree of conversion in IDM is due to its chemical composition and filler content. Also, the similarity in linear polymerization shrinkage between IDM and tetric ceram may be caused by the low degree of conversion in IDM.

  6. Comparison of GC-ICP-MS and HPLC-ICP-MS for species-specific isotope dilution analysis of tributyltin in sediment after accelerated solvent extraction

    International Nuclear Information System (INIS)

    Wahlen, Raimund; Wolff-Briche, Celine

    2003-01-01

    This study describes a direct comparison of GC and HPLC hyphenated to ICP-MS determination of tributyltin (TBT) in sediment by species-specific isotope dilution analysis (SS-IDMS). The certified reference sediment PACS-2 (NRC, Canada) and a candidate reference sediment (P-18/HIPA-1) were extracted using an accelerated solvent extraction (ASE) procedure. For comparison of GC and LC methods an older bottle of PACS-2 was used, whilst a fresh bottle was taken for demonstration of the accuracy of the methods. The data obtained show good agreement between both methods for both the PACS-2 sediment (LC-ICP-IDMS 828±87 ng g -1 TBT as Sn, GC-ICP-IDMS 848±39 ng g -1 TBT as Sn) and the P-18/ HIPA-1 sediment (LC-ICP-IDMS 78.0±9.7 ng g -1 TBT as Sn, GC-ICP-IDMS 79.2±3.8 ng g -1 TBT as Sn). The analysis by GC-ICP-IDMS offers a greater signal-to-noise ratio and hence a superior detection limit of 0.03 pg TBT as Sn, in the sediment extracts compared to HPLC-ICP-IDMS (3 pg TBT as Sn). A comparison of the uncertainties associated with both methods indicates superior precision of the GC approach. This is related to the better reproducibility of the peak integration, which affects the isotope ratio measurements used for IDMS. The accuracy of the ASE method combined with HPLC-ICP-IDMS was demonstrated during the international interlaboratory comparison P-18 organised by the Comite Consultatif pour la Quantite de Matiere (CCQM). The results obtained by GC-ICP-IDMS for a newly opened bottle of PACS-2 were 1087±77 ng g -1 Sn for DBT and 876±51 ng g -1 Sn for TBT (expanded uncertainties with a coverage factor of 2), which are in good agreement with the certified values of 1090±150 ng g -1 Sn and 980±130 ng g -1 Sn, respectively. (orig.)

  7. Orkes Simfoni Jakarta dalam Perspektif Habitus Bourdieu

    Directory of Open Access Journals (Sweden)

    Y. Edhi Susilo

    2014-11-01

    Full Text Available Artikel ini membahas habitus orkes simfoni dan pelaku orkes simfoni menurutperspektif habitus Bourdieu. Orkes simfoni sebagai sebuah habitus sudahberlangsung di Indonesia.Perjalanannya diwarnai dengan perubahan-perubahanpada kondisi yang melingkupinya dan para pelaku orkestra yang mendukungnya.Tulisan ini akanmenguraikan keberadaan orkes simfoni sejak tahun 1950-anhingga kondisi saat ini. Penelitian ini bertujuan untuk mengetahui sejarah danperkembangan orkes simfoni di Indonesia. Teori yang digunakan adalah teori sosialPierre Bourdieu mengenai ”habitus” dan ”pembentukan kelas”. Jakarta Symphony Orchestra on Bourdieu’s Habitus Perspective. This articlemainly discusses the habitus of symphony orchestra and the players according toBourdieu’s habitus perspective. The symphony orchestra as a habitus has already takenplace in Indonesia. The journey was influenced by the changes in the surroundingconditions and the supporting orchestra players. This articlewill describe the existenceof the symphony orchestra since the 1950s to its condition lately. Moreover, this studyisaimed to determine the history and development of the symphony orchestra in Indonesia.The theory used in the study is the social theory of Pierre Bourdieu on “habitus” and“class formation”.

  8. An imprecise probability approach for the detection of over and underused taxonomic groups with the Campania (Italy) and the Sierra Popoluca (Mexico) medicinal flora.

    Science.gov (United States)

    Weckerle, Caroline S; Cabras, Stefano; Castellanos, Maria Eugenia; Leonti, Marco

    2012-06-26

    We use the IDM model to test for over- and underuse of plant taxa as source for medicine. In contrast to the Bayes approach, which only considers the uncertainty around the data of medicinal plant surveys, the IDM model also takes the uncertainty around the inventory of the flora into account, which is used for the comparison between medicinal and local floras. Statistical analysis of the medicinal flora of Campania (Italy) and of the medicinal flora used by the Sierra Popoluca (Mexico) was performed with the IDM model and the Bayes approach. For Campania 423 medicinal plants and 2237 vascular plant species and for the Sierra Popoluca 605 medicinal plants and 2317 vascular plant species were considered. The IDM model (s=4) indicates for Campania the Lamiaceae and Rosaceae as overused, and the Caryophyllaceae, Poaceae, and Orchidaceae as underused. Among the Popoluca the Asteraceae and Piperaceae turn out to be overused, while Cyperaceae, Poaceae, and Orchidaceae are underused. In comparison with the Bayes approach, the IDM approach indicates fewer families as over- or underused. The IDM model leads to more conservative results compared to the Bayes approach. Only relatively few taxa are indicated as over- or underused. The larger the families (n(j)'s) are, the more similar do the results of the two approaches turn out. In contrast to the Bayes approach, small taxa with most or all species used as medicine (e.g., n(j)=2, x(j)=2) tend not to be indicated as overused with the IDM model. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  9. EFEKTIFITAS METODE GROUP FIELD TOUR MELALUI TEKNIK SIMFONI OTAK DALAM PEMBELAJARAN PENULISAN SASTRA KREATIF

    Directory of Open Access Journals (Sweden)

    Akhmad Fauzan

    2014-03-01

    Full Text Available Group field tour methode by Brain Symphoni Technique Investigate how the advantages of implementation. To get the goal the reseacher used Quasi experiment by giving pre test and post test to two different classes as experiment and control class. In experiment class is given the reatment but control class is not. Based on that fact, the problems as follow (1 Is there any difference between creative student used group field tour methode by Brain Symphony technique and not? (2 Is the usage group field tour methode significant by Brain Symphoni thechnique in Creative Literature Writing. The technique is using Quasi experiment methode. Student used this methode is increasing the competence in short story. It showed by pre test and post test comparasion. In post test the score is significant comparated to control class. The control class is increasing too but it is not as big as experiment class. Key word: group field tour, literature learning.

  10. Holistic Privacy-Preserving Identity Management System for the Internet of Things

    Directory of Open Access Journals (Sweden)

    Jorge Bernal Bernabe

    2017-01-01

    Full Text Available Security and privacy concerns are becoming an important barrier for large scale adoption and deployment of the Internet of Things. To address this issue, the identity management system defined herein provides a novel holistic and privacy-preserving solution aiming to cope with heterogeneous scenarios that requires both traditional online access control and authentication, along with claim-based approach for M2M (machine to machine interactions required in IoT. It combines a cryptographic approach for claim-based authentication using the Idemix anonymous credential system, together with classic IdM mechanisms by relying on the FIWARE IdM (Keyrock. This symbiosis endows the IdM system with advanced features such as privacy-preserving, minimal disclosure, zero-knowledge proofs, unlikability, confidentiality, pseudonymity, strong authentication, user consent, and offline M2M transactions. The IdM system has been specially tailored for the Internet of Things bearing in mind the management of both users’ and smart objects’ identity. Moreover, the IdM system has been successfully implemented, deployed, and tested in the scope of SocIoTal European research project.

  11. The Research of Car-Following Model Based on Real-Time Maximum Deceleration

    Directory of Open Access Journals (Sweden)

    Longhai Yang

    2015-01-01

    Full Text Available This paper is concerned with the effect of real-time maximum deceleration in car-following. The real-time maximum acceleration is estimated with vehicle dynamics. It is known that an intelligent driver model (IDM can control adaptive cruise control (ACC well. The disadvantages of IDM at high and constant speed are analyzed. A new car-following model which is applied to ACC is established accordingly to modify the desired minimum gap and structure of the IDM. We simulated the new car-following model and IDM under two different kinds of road conditions. In the first, the vehicles drive on a single road, taking dry asphalt road as the example in this paper. In the second, vehicles drive onto a different road, and this paper analyzed the situation in which vehicles drive from a dry asphalt road onto an icy road. From the simulation, we found that the new car-following model can not only ensure driving security and comfort but also control the steady driving of the vehicle with a smaller time headway than IDM.

  12. Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia.

    Science.gov (United States)

    Sarikabadayi, Yusuf Unal; Aydemir, Ozge; Aydemir, Cumhur; Uras, Nurdan; Oguz, Serife Suna; Erdeve, Omer; Dilmen, Ugur

    2011-01-01

    There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the influence of maternal hyperglycemia on these parameters. A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had significantly higher TOS (p IDM, and a significant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth.

  13. What is needed for informed decisions about prostate cancer screening: perspectives of African-American and Hispanic men.

    Science.gov (United States)

    McFall, Stephanie L; Ureda, John; Byrd, Theresa L; Valdes, Adriana; Morales, Pat; Scott, Delores B; Williams, Deloris; Calderon-Mora, Jessica; Casillas, Myryam E; Chan, Evelyn C Y

    2009-04-01

    Professional guidelines suggest that men should learn about risks and benefits of screening to make informed decisions consistent with their preferences. We used concept mapping to investigate views of informed decision making (IDM) of minority men. Statements about what men need for IDM about prostate cancer screening were sorted by similarity and rated for importance by 16 Hispanic and 15 African-American men. Multidimensional scaling and cluster analysis were used to develop a concept map for IDM. The 10-cluster solution was selected. The clusters rated most important were labeled Future Considerations, What to Know and Decision to Make. Clusters labeled Social Support and Sharing Perspectives depicted social aspects of the decision and were intermediate in importance. There was strong correlation in relative importance ratings of clusters by African-American and Hispanic men. However, African-American men gave higher importance ratings than Hispanic men. Concept mapping, a method with strong participatory elements, was useful in identifying conceptual frameworks for IDM of African-American and Hispanic men. Health education to support IDM requires some shifts in focus and strategy. It is important that interventions with minority men build upon a strong conceptual framework.

  14. Beyond the 'Gothic' : Havergal Brian and his orchestral music of the 1930s

    OpenAIRE

    O'Leary, Martin

    2004-01-01

    This thesis presents the most detailed study yet of the music of the English composer William Havergal Brian (1876-1972). It concentrates on the orchestral music written in a single decade — the 1930s — at a time when he was arguabh at the height of his powers. The music of this decade follows on form the completion of his most famous — and notorious — work, the massive Gothic Symphony- (No. 1). The works written during this decade, and in particular the two symphonies (the second and third),...

  15. Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling.

    Science.gov (United States)

    Giridharan, G A; Lederer, C; Berthe, A; Goubergrits, L; Hutzenlaub, J; Slaughter, M S; Dowling, R D; Spence, P A; Koenig, S C

    2011-12-01

    Historically, single port valveless pneumatic blood pumps have had a high incidence of thrombus formation due to areas of blood stagnation and hemolysis due to areas of high shear stress. To ensure minimal hemolysis and favorable blood washing characteristics, particle image velocimetry (PIV) and computational fluid dynamics (CFD) were used to evaluate the design of a new single port, valveless counterpulsation device (Symphony). The Symphony design was tested in 6-h acute (n=8), 5-day (n=8) and 30-day (n=2) chronic experiments in a calf model (Jersey, 76 kg). Venous blood samples were collected during acute (hourly) and chronic (weekly) time courses to analyze for temporal changes in biochemical markers and quantify plasma free hemoglobin. At the end of the study, animals were euthanized and the Symphony and end-organs (brain, liver, kidney, lungs, heart, and spleen) were examined for thrombus formations. Both the PIV and the CFD showed the development of a strong moving vortex during filling phase and that blood exited the Symphony uniformly from all areas during ejection phase. The laminar shear stresses estimated by CFD remained well below the hemolysis threshold of 400 Pa inside the Symphony throughout filling and ejection phases. No areas of persistent blood stagnation or flow separation were observed. The maximum plasma free hemoglobin (<10mg/dl), average platelet count (pre-implant = 473 ± 56 K/μl and post-implant = 331 ± 62 K/μl), and average hematocrit (pre-implant = 31 ± 2% and post-implant = 29 ± 2%) were normal at all measured time-points for each test animal in acute and chronic experiments. There were no changes in measures of hepatic function (ALP, ALT) or renal function (creatinine) from pre-Symphony implantation values. The necropsy examination showed no signs of thrombus formation in the Symphony or end organs. These data suggest that the designed Symphony has good washing characteristics without persistent areas of blood stagnation sites

  16. Sneutrino dark matter in gauged inverse seesaw models for neutrinos.

    Science.gov (United States)

    An, Haipeng; Dev, P S Bhupal; Cai, Yi; Mohapatra, R N

    2012-02-24

    Extending the minimal supersymmetric standard model to explain small neutrino masses via the inverse seesaw mechanism can lead to a new light supersymmetric scalar partner which can play the role of inelastic dark matter (IDM). It is a linear combination of the superpartners of the neutral fermions in the theory (the light left-handed neutrino and two heavy standard model singlet neutrinos) which can be very light with mass in ~5-20 GeV range, as suggested by some current direct detection experiments. The IDM in this class of models has keV-scale mass splitting, which is intimately connected to the small Majorana masses of neutrinos. We predict the differential scattering rate and annual modulation of the IDM signal which can be testable at future germanium- and xenon-based detectors.

  17. Object Classification based Context Management for Identity Management in Internet of Things

    DEFF Research Database (Denmark)

    Mahalle, Parikshit N.; Prasad, Neeli R.; Prasad, Ramjee

    2013-01-01

    As computing technology is becoming more tightly coupled into dynamic and mobile world of the Internet of Things (IoT), security mechanism is more stringent, flexible and less intrusive. Scalability issue in IoT makes identity management (IdM) of ubiquitous objects more challenging, and there is ......As computing technology is becoming more tightly coupled into dynamic and mobile world of the Internet of Things (IoT), security mechanism is more stringent, flexible and less intrusive. Scalability issue in IoT makes identity management (IdM) of ubiquitous objects more challenging......, and there is a need of context-aware access control solution for IdM. Confronting uncertainty of different types of objects in IoT is not easy. This paper presents the logical framework for object classification in context aware IoT, as richer contextual information creates an impact on the access control. This paper...

  18. Determination of Trace Iron in Red Wine by Isotope Dilution Mass Spectrometry Using Multiple-Collector Inductively Coupled Plasma Mass Spectrometry

    International Nuclear Information System (INIS)

    Zhou Tao; Wang Jun; Lu Hai; Zhou Yuanjing; Li Haifeng

    2009-01-01

    This paper introduces determination of trace iron in red wine certified reference material by isotope dilution mass spectrometry (IDMS) method using a multiplecollector inductively coupled plasma mass spectrometry, equipped with a hexapole collision cell. The measurement procedure of iron isotopic abundance ratios was deeply researched. Reduced polyatomic ion interferences to iron isotopes ion by collision reaction using Ar and H 2 gas, high precise isotopic abundance ratios were achieved. Two relative measurement methods (ICP-MS and ICP-OES) were used to analyze trace iron in red wine. The results are compared with IDMS results, which indicate that they are accordant. The uncertainty analyses include each uncertainty factor in whole experiment and the uncertainty of used certified reference material and it shows that the procedure blank is not neglectable to detect limit and precision of the method. The establishment of IDMS method for analysis of trace iron in red wine supports the certification of certified reference materials. (authors)

  19. Determination of lead in red wine for CCQM-K30 international comparison by using ID-ICPMS

    International Nuclear Information System (INIS)

    Zhou Tao; Wang Jun; Lu Hai; Zhao Motian

    2007-01-01

    The content of lead in red wine for CCQM-K30 international key comparison is determined by using isotope dilution mass spectrometry (IDMS). This test almost reach detect limit of the method because the content of lead in red wine was only 3 ng/g and the procedure blank was about 0.3 ng. The comparison results indicate that it is easy to achieve agreements using IDMS. In uncertainty analysis, all of the factors about IDMS method were considered. But, procedure blank took great inference to experiment precision and enlarged the total uncertainty. Therefore the controls of procedure blank were very important for the analysis of ultra-trace concentration of samples. (authors)

  20. Intrauterine hyperglycemia-induced inflammatory signalling via the receptor for advanced glycation end products in the cardiac muscle of the infants of diabetic mother rats.

    Science.gov (United States)

    Kawaharada, Ritsuko; Masuda, Haruna; Chen, Zhenyi; Blough, Eric; Kohama, Tomoko; Nakamura, Akio

    2017-09-23

    Gestational diabetes is associated with increased risk to the health of the mother and her offspring. In particular, the infants of diabetic mothers (IDMs) exhibit elevated levels of preterm birth, macrosomia, hypoglycemia, hypocalcemia, and cardiomyopathy. We have previously reported that IDMs showed abnormalities in cardiac Akt-related insulin signalling, and that these deficiencies in Akt-related signalling were attenuated by supplementing the maternal diet with fish-oil. Herein, we investigated whether the eicosapentaenoic acid (EPA) found in fish oil can be used to attenuate diabetes associated impairments in cardiomyocyte signalling. Pregnant diabetic rats were administered streptozotocin before receiving EPA or water, and their infants were designated IDM/EPA, IDM/W. We assessed the potential molecular pathway for this effect in the primary cardiac cell from newborn rat hearts. Insulin resistance as determined by diminished GLUT4 translocation following insulin stimulation, the levels of advanced glycation end products (AGEs) and reactive oxygen species were elevated in the neonatal hearts of IDM/W compared with that seen in the offspring born from non-diabetic control animals. Similarly, the receptor of AGEs (RAGE) mRNA levels, reactive oxygen species and the amount of nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) mRNA were higher in the hearts from the IDM/W when compared to that observed in the hearts of offspring born to non-diabetic animals. These deleterious effects of gestational diabetes were significantly decreased in the offspring of diabetic mothers receiving EPA supplementation. Taken together, our data suggest that the EPA in fish oil may improve the impaired signalling and the excessive protein glycation in the cardiac muscles of infants exposed to intrauterine hyperglycemia.

  1. Health literacy skills for informed decision making in colorectal cancer screening: Perceptions of screening invitees and experts.

    Science.gov (United States)

    Woudstra, Anke J; Timmermans, Daniëlle R M; Uiters, Ellen; Dekker, Evelien; Smets, Ellen M A; Fransen, Mirjam P

    2017-12-20

    The process of informed decision making (IDM) requires an adequate level of health literacy. To ensure that all individuals have equal opportunity to make an informed decision in colorectal cancer (CRC) screening, it is essential to gain more insight into which health literacy skills are needed for IDM. Our aims were (i) to explore how individuals make a decision about CRC screening and (ii) to explore which skills are needed for IDM in CRC screening and (iii) to integrate these findings within a conceptual framework. We conducted 3 focus groups with individuals eligible for CRC screening (n = 22) and 2 focus groups with experts in the field of health literacy, oncology and decision making, including scientific researchers and health-care professionals (n = 17). We used framework analysis to analyse our data. We identified and specified ten health literacy skills, which varied from the ability to read and understand CRC screening information to the ability to weigh up pros and cons of screening for personal relevance. The skills were linked to 8 decision-making stages in CRC screening within a conceptual framework. We found differences in perceptions between screening invitees and experts, especially in the perceived importance of CRC screening information for IDM. This study provides insight into the decision-making stages and health literacy skills that are essential for IDM in CRC screening. The proposed conceptual framework can be used to inform the development of context-based measurement of health literacy and interventions to support IDM in cancer screening. © 2017 The Authors Health Expectations published by John Wiley & Sons Ltd.

  2. Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis.

    Science.gov (United States)

    Petronilho, Fabricia; Araújo, João H; Steckert, Amanda V; Rezin, Gislaine T; Ferreira, Gabriela K; Roesler, Rafael; Schwartsmann, Gilberto; Dal-Pizzol, Felipe; Streck, Emilio L

    2009-08-01

    It has been proposed that reactive oxygen species play a causative role of gastric mucosal damage induced by increased gastric secretion. Gastrin-releasing peptide is a typical neuropeptide that stimulates acid secretion by release of gastrin. In the present work we have investigated the mechanism of indomethacin (IDM)-induced gastric ulcer caused by ROS and determined the effects of a selective gastrin-releasing peptide receptor antagonist, RC-3095, alone and in association with omeprazole (OM) and compared it with an established antioxidant compound N-acetyl cysteine (NAC). Adult male Wistar rats were pre-treated for 7 days with OM, RC-3095, NAC, both drugs and water (control). The animals were then submitted to fasting for 24h; IDM was administered. Rats were killed 6h after that and the stomachs were used for evaluation of macroscopic damage and oxidative stress parameters. Our results showed that IDM increased mitochondrial superoxide production; OM and RC-3095 alone did not prevent such effect, but the combination of these drugs was effective. TBARS assay revealed that IDM-induced lipid peroxidation in gastric tissue and that OM and RC-3095, alone or in combination, prevented this effect with superior action that NAC. Finally, we verified that IDM increased protein carbonyl content and that this effect was prevented RC-3095, alone or in combination with OM, being similar to standard antioxidant. The present results support the view that, besides the inhibition of acid secretion, the protective effects exerted by OM and RC-3095 against IDM-induced gastric damage can be ascribed to a reduction of gastric oxidative injury.

  3. Similar outcome in insulin-dependent and noninsulin-dependent diabetic patients after off-pump coronary artery bypass grafting with multiple skeletonized arterial conduits.

    Science.gov (United States)

    Suzuki, Tomoaki; Asai, Tohru; Nota, Hiromitsu; Kinoshita, Takeshi; Fujino, Susumu; Takashima, Noriyuki

    2015-05-01

    We were interested in whether current multiarterial off-pump coronary artery bypass graft surgery can improve the clinical outcome for insulin-dependent diabetes mellitus patients. Between January 2002 and December 2013, 1,064 consecutive patients underwent isolated off-pump coronary artery bypass surgery at our hospital; 551 of these patients had diabetes. Of these 551 patients, 166 had insulin-dependent diabetes (IDM) and the remaining 385 had noninsulin-dependent diabetes (NIDM). The propensity score was calculated to achieve one-to-two matching sets (IDM 143 versus NIDM 286). Ten patients (3.5%) in the NIDM group and 2 patients (1.4%) in the IDM group died in hospital (p = 0.18). Insulin dependency was not an independent risk factor for any early death or major complications. Follow-up was complete for 96.5% of the patients, with a mean follow-up of 4.6 ± 3.8 years. Overall survival rate at 10 years was 76.3% for the NIDM group and 73.1% for the IDM group (p = 0.79). The rate of 10-year actuarial freedom from major adverse cardiac events was 89.6% in the NIDM group and 86.3% in the IDM group (p = 0.72). Multivariate Cox proportional hazard regression analysis revealed that female sex, congestive heart failure, previous myocardial infarction, lower ejection fraction, and at least one major complication were independent risk factors for combined cardiac events. Insulin dependency did not affect any outcome in the long term. Early and long-term outcomes after off-pump skeletonized multiarterial coronary artery bypass graft surgery were similar among the IDM and NIDM patients. Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  4. Validity of the ID-Migraine screener in the workplace.

    Science.gov (United States)

    Siva, A; Zarifoglu, M; Ertas, M; Saip, S; Karli, H N; Baykan, B; Keskinaslan, A; Senocak, M

    2008-04-15

    The impact of migraine on physical, social, and emotional performance is considerable, yet it remains an underdiagnosed disorder. ID-Migraine is a validated migraine-screening tool developed to facilitate diagnosis. This study evaluated the validity and use of the Turkish version of the ID-Migraine screener (ID-Ms) in the workplace, and measured the impact of headache on disability, productivity, and quality of life among the workforce. A total of 465 employees from four companies were interviewed for screening with the ID-Ms. Subjects were included in the study if they reported two or more headaches in the past 3 months and gave a positive answer to one of the two ID-Ms prescreening questions. Eligible subjects completed the ID-Ms, the Migraine Disability Assessment Questionnaire, and the Medical Outcomes Study 36-Item Short Form Health Survey. Subjects were then evaluated for confirmation of their diagnosis according to the International Classification of Headache Disorders, 2nd edition (ICHD-2) criteria. A total of 227 subjects (mean age 31.9 +/- 5.9 years; 65.6% women) completed the study. Migraine was diagnosed in 106 of the 227 subjects (46.7%) according to the ID-Ms and in 117 of the 227 subjects (51.5%) according to ICHD-2 criteria. The sensitivity of the ID-Ms was 70.9%, specificity was 79.1% and Cohen kappa value was 0.50. Workdays lost over the previous 3 months due to headache amounted to 8.7 +/- 9.5 days for migraine-positive and 4.9 +/- 6.6 days for migraine-negative subjects. The Turkish version of the ID-Migraine screener is a valid tool for identifying subjects with migraine in the workplace.

  5. Instantaneous-to-daily GPP upscaling schemes based on a coupled photosynthesis-stomatal conductance model: correcting the overestimation of GPP by directly using daily average meteorological inputs.

    Science.gov (United States)

    Wang, Fumin; Gonsamo, Alemu; Chen, Jing M; Black, T Andrew; Zhou, Bin

    2014-11-01

    Daily canopy photosynthesis is usually temporally upscaled from instantaneous (i.e., seconds) photosynthesis rate. The nonlinear response of photosynthesis to meteorological variables makes the temporal scaling a significant challenge. In this study, two temporal upscaling schemes of daily photosynthesis, the integrated daily model (IDM) and the segmented daily model (SDM), are presented by considering the diurnal variations of meteorological variables based on a coupled photosynthesis-stomatal conductance model. The two models, as well as a simple average daily model (SADM) with daily average meteorological inputs, were validated using the tower-derived gross primary production (GPP) to assess their abilities in simulating daily photosynthesis. The results showed IDM closely followed the seasonal trend of the tower-derived GPP with an average RMSE of 1.63 g C m(-2) day(-1), and an average Nash-Sutcliffe model efficiency coefficient (E) of 0.87. SDM performed similarly to IDM in GPP simulation but decreased the computation time by >66%. SADM overestimated daily GPP by about 15% during the growing season compared to IDM. Both IDM and SDM greatly decreased the overestimation by SADM, and improved the simulation of daily GPP by reducing the RMSE by 34 and 30%, respectively. The results indicated that IDM and SDM are useful temporal upscaling approaches, and both are superior to SADM in daily GPP simulation because they take into account the diurnally varying responses of photosynthesis to meteorological variables. SDM is computationally more efficient, and therefore more suitable for long-term and large-scale GPP simulations.

  6. Cord Serum Lipid Profile of Infants of Diabetic Mothers

    Directory of Open Access Journals (Sweden)

    Jasim Almusawi

    2015-12-01

    Full Text Available Background: Infants of diabetic mothers (IDM is a critical issue in pediatrics, which is regarded as a major risk factor for birth trauma, respiratory distress syndrome (RDS, birth asphyxia, transient tachypnea of the newborn (TTN and jaundice. IDM is also a risk factor for microvascular (e.g., ocular and renal complications and macrovascular complications (e.g., cerebrovascular accident, atherosclerosis and cardiovascular complications. Lipids are a heterogeneous group of hydrophobic organic molecules which can be extracted from tissues using non-polar solvents. Lipids, due to their hydrophobic property, are mainly found in membranes enclosing various cell organelles. Diabetes mellitus management with insulin (nowadays also with oral hypoglycemic medications has improved the outcomes of gestational diabetes mellitus (GDM (most infants born to diabetic mother are large for gestational age. The neonatal mortality rate in IDM is over five times higher than that of infants of non-diabetic mothers. In this study, therefore, we aimed to assess the effect of maternal diabetes on cord serum lipid profile. Methods: This prospective (case-control study was carried out on 60 infants born in Al-Zahra teaching hospital during February 2014–October 2014. The study group consisted of 30 randomly chosen IDM, and the control group comprised 30 infants who were born to healthy mothers. Results: The results of this study demonstrated that there are significant differences between IDM and infants of healthy mothers regarding lipid profile and birth weight. Conclusion: This study confirms that cord serum lipid profile (serum cholesterol, serum triglycerides and low-density lipoprotein is higher at birth in IDM. Moreover, this study shows a significant association between lipid profile and body weight.

  7. Lake Bacterial Assemblage Composition Is Sensitive to Biological Disturbance Caused by an Invasive Filter Feeder.

    Science.gov (United States)

    Denef, Vincent J; Carrick, Hunter J; Cavaletto, Joann; Chiang, Edna; Johengen, Thomas H; Vanderploeg, Henry A

    2017-01-01

    One approach to improve forecasts of how global change will affect ecosystem processes is to better understand how anthropogenic disturbances alter bacterial assemblages that drive biogeochemical cycles. Species invasions are important contributors to global change, but their impacts on bacterial community ecology are rarely investigated. Here, we studied direct impacts of invasive dreissenid mussels (IDMs), one of many invasive filter feeders, on freshwater lake bacterioplankton. We demonstrated that direct effects of IDMs reduced bacterial abundance and altered assemblage composition by preferentially removing larger and particle-associated bacteria. While this increased the relative abundances of many free-living bacterial taxa, some were susceptible to filter feeding, in line with efficient removal of phytoplankton cells of <2 μm. This selective removal of particle-associated and larger bacteria by IDMs altered inferred bacterial functional group representation, defined by carbon and energy source utilization. Specifically, we inferred an increased relative abundance of chemoorganoheterotrophs predicted to be capable of rhodopsin-dependent energy generation. In contrast to the few previous studies that have focused on the longer-term combined direct and indirect effects of IDMs on bacterioplankton, our study showed that IDMs act directly as a biological disturbance to which freshwater bacterial assemblages are sensitive. The negative impacts on particle-associated bacteria, which have been shown to be more active than free-living bacteria, and the inferred shifts in functional group representation raise the possibility that IDMs may directly alter bacterially mediated ecosystem functions. IMPORTANCE Freshwater bacteria play fundamental roles in global elemental cycling and are an intrinsic part of local food webs. Human activities are altering freshwater environments, and much has been learned regarding the sensitivity of bacterial assemblages to a variety of

  8. Integrated Monitoring System II (IMS-II). User's manual

    Energy Technology Data Exchange (ETDEWEB)

    Gallegos, M.H.

    1985-08-01

    The IMS-II was designed to monitor up to four unattended areas containing assets of safeguards interest through the use of video equipment and motion detectors. One module of the system equipment is the Inspector Display Module (IDM), which interacts with the Data Collection Module (DCM) to initialize the system and retrieve data from the DCM. This document is intended to guide an inspector through the various functions of the IDM for the purpose of initializing and retrieving information once the system is operational. 5 figs.

  9. In vivo sensitivity of Phakopsora pachyrhizi to DMI and QoI fungicides

    Directory of Open Access Journals (Sweden)

    Erlei Melo Reis

    2015-03-01

    Full Text Available In in vivo experiments the sensitivity of 18 isolates of Phakopsora pachyrhizi from several regions of Brazil to IDM fungicides (cyproconazole, epoxiconazole and tebuconazole and an IQE (pyraclostrobin were evaluated. The assessments were based on leaflet uredia density. Inhibitory concentration (IC50 and sensitivity reduction factor were determined for all fungicide x strain interactions. Tebuconazole sensitivity reduction was detected for most fungus isolates. In contrast, there was no fungicide shift in sensitivity of the fungus to pyraclostrobin. We conclude that the control failure of soybean rust found in some farms is due to the reduced sensitivity of the fungus to the IDM fungicide and that it remains sensitive to pyraclostrobin.

  10. A systematic halo-independent analysis of direct detection data within the framework of Inelastic Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Scopel, Stefano; Yoon, Kook-Hyun, E-mail: scopel@sogang.ac.kr, E-mail: koreasds@naver.com [Department of Physics, Sogang University, Seoul 121-742 (Korea, Republic of)

    2014-08-01

    We present a systematic halo-independent analysis of available Weakly Interacting Massive Particles (WIMP) direct detection data within the framework of Inelastic Dark Matter (IDM). We show that, when the smallest number of assumptions is made on the WIMP velocity distribution in the halo of our Galaxy, it is possible to find values of the WIMP mass and the IDM mass splitting for which compatibility between present constraints and any of the three experiments claiming to see a WIMP excess among DAMA, CDMS-Si and CRESST can be achieved.

  11. Delivering COBie data - Focus on curtain walls and building envelopes

    DEFF Research Database (Denmark)

    Karlshøj, Jan; Borin, P.; Carradori, M.

    BIM policies and requirements, this paper shows the results obtained applying COBie to complex products such as curtain walls. Two Information Delivery Manuals (IDMs) were also developed, in order to provide a com-monly known and standardized framework, which can regulate the COBie-based information...... exchanges. Fu-ture developments of this study could concern the application of the developed IDMs to different case studies in order to overtake that specificity characterizing each single project and verify the validity of the proposal....

  12. Integrated disease management improves one-year quality of life in primary care COPD patients: a controlled clinical trial.

    Science.gov (United States)

    Chavannes, Niels H; Grijsen, Marlous; van den Akker, Marjan; Schepers, Huub; Nijdam, Maddy; Tiep, Brian; Muris, Jean

    2009-09-01

    AIMD: To assess the long-term effectiveness of an integrated disease management (IDM) program (consisting of optimal medication, reactivation, education, and exacerbation management) in primary care patients with chronic obstructive pulmonary disease (COPD). Controlled trial comparing the effects of IDM on quality of life--assessed by the St. George's Respiratory Questionnaire (SGRQ)--in primary care COPD patients. The minimal clinically important change on the SGRQ was accepted as being -4 points. Baseline and one year differences were compared using paired sample T-tests. The differential effects of an FEV1/FVC ratio 2 and FEV1/FVC 2.

  13. Evaluation of behavioral differences between native polycyclic aromatic hydrocarbons and (13)C-labeled internal standards during clean-up steps of analysis.

    Science.gov (United States)

    Itoh, Nobuyasu; Numata, Masahiko; Yarita, Takashi

    2007-10-01

    We confirmed that concentrations of polycyclic aromatic hydrocarbons (PAHs) obtained by isotope dilution mass spectrometry (IDMS) using the corresponding (13)C-labeled internal standards are reliable even after clean-up steps. Change in the ratio of phenanthrene to (13)C(6)-phenanthrene was less than 0.2%, although the recovery yield of (13)C(6)-phenanthrene decreased to 60%. Since changes in the ratios were commonly within the relative standard deviations of the concentrations (1.5 - 5.4%) obtained using gas chromatography-mass spectrometry in combination with pressurized-liquid extraction, concentrations obtained by IDMS with (13)C-PAHs should be reliable.

  14. Paper and analysis of internal Clock by Monolake

    OpenAIRE

    RAMSAY, Benjamin

    2012-01-01

    Monolake’s ‘Internal Clock’ was released on the 2009 album ‘Silence’ on the Imbalance Computer Music label from Berlin, Germany. The piece is an outstanding example of where contemporary dance music, which some might call electronica or IDM, crosses over with acousmatic composition traditions.\\ud \\ud This paper aims to explore how we might apply current acousmatic music theory to explain some of the sounds, shapes and arrangements within the field of IDM and less conventional forms of electro...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2008-10-15

    Oct 15, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 4. Combating emerging infectious diseases in India: Orchestrating a symphony. Lalit Kant. Volume 33 Issue 4 November 2008 pp 425-427. Fulltext. Click here to view fulltext PDF. Permanent link:

  16. Ujuv saadik / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2010-01-01

    Kohtumisest Eestis viibinud Louis Kahni projekteeritud kontserdilaeval ringi sõitva American Wind Symphony Orchresta juhataja Robert Boudreau'ga. Laeva sünnist, tema loojast, laeva tulevikust, Eestis 2011. a. kontserttuuri tegemisest. Eesti Arhitektide Liidu ideest osta 2011. a. kultuuripealinna ürituste raames toimuva L. Kahnile pühendatud seminari puhuks tema kavandatud kontserdilaev

  17. The Economic Impact of Ten Cultural Institutions on the Economy of the Salt Lake SMSA.

    Science.gov (United States)

    Cwi, David

    The impact of 10 cultural institutions on the Salt Lake City economy was determined by measuring their 1978 direct and indirect financial effects. The institutions are Ballet West, Pioneer Memorial Theatre, Repertory Dance Theatre, Salt Lake City Art Center, Theatre 138, Tiffany's Attic, Utah Museum of Fine Arts, Utah Symphony, Utah Opera Company,…

  18. Pilk maestro Neeme Järvi muusikalisse loometöösse / Airi Vaga

    Index Scriptorium Estoniae

    Vaga, Airi, 1940-

    2006-01-01

    kohtumisest New Jersey Symphony Orchestra mängijate ja dirigendiga 13. jaanuaril 2006 Newarkis, kus tutvustati sümfooniaorkestri 2006 - 2007. aasta programmi ning räägiti tööst Beethoveni 9. sümfoonia ettevalmistamisel kontserdiks. Tunti muret noorte muusikakasvatuse ühekülgse arengu pärast

  19. Sibelius. Karelia Suite, Op. 11 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1996-01-01

    Uuest heliplaadist "Sibelius. Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi" DG 447 760-2GH (72 minutes: DDD)

  20. Nielsen: Aladdin-Suite, FS89. Maskarade-Overture / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1996-01-01

    Uuest heliplaadist "Nielsen: Aladdin-Suite, FS89. Maskarade-Overture, Prelude, Act 2. The Cockerels' Dance. Rhapsody Overture: An imaginary journey to the Faroe Islands, FS123. Helios Overture, FS32. Saga-Drom, FS46. Pan and Syrinx, FS87. Gothenburg Symphony Orchestra, Neeme Järvi" DG 447 757-2GH (72 minutes: DDD)

  1. Catching a Glimpse of the Future: One Year on in a Youth String Project

    Science.gov (United States)

    Power, Anne M.; Powell, Sarah J.

    2016-01-01

    The provision of musical experiences for youth, especially in low socio-economic areas (SES), requires funded support and imaginative resourcing. This paper presents data from the Penrith (NSW Australia) Youth String Program offered in partnership by the Australian Chamber Orchestra (ACO), Penrith Symphony Orchestra (PSO) and The Joan Sutherland…

  2. 77 FR 33595 - African-American Music Appreciation Month, 2012

    Science.gov (United States)

    2012-06-07

    ..., symphony, and classical music by bringing energy and creativity to traditional genres. At its core, African... Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8832 of June 1, 2012 African-American Music... piece of American culture, music offers a vibrant soundtrack to the story of our people and our Union...

  3. Beethoven, Ludwig van: Violinkonzert D-Dur op. 61

    Index Scriptorium Estoniae

    1997-01-01

    Uuest heliplaadist "Beethoven, Ludwig van: Violinkonzert D-Dur op. 61 (Kadenz: Alfred Schnittke). Romanzen für Violine und Orchester op. 40 und 50. Estonian National Symphony Orchestra, Arvo Volmer". Globe GLO 5155, distribution Talis (CD:153F). 1996. TT:1h 01'56"

  4. Nadia Boulanger

    Science.gov (United States)

    Hoover, Suzanne R.

    1977-01-01

    The author, now a member of the literature faculty at Sarah Lawrence College, recalls her learning and life experiences with Nadia Boulanger, a pioneer music educator and the first woman to conduct a number of the world's great symphony orchestras. (RK)

  5. Pop / Priit Hõbemägi

    Index Scriptorium Estoniae

    Hõbemägi, Priit, 1957-

    2006-01-01

    Heliplaatidest: The Manhattan Transfer "The Symphony Sessions", The Magic Numbers "Those The Brokes", Electronic "Get the Message: the Best of Electronic", ...And You Will Know Us by the Trail of Dead "So Divided", Tutty Moreno "Magica", Lindsey Buckingham "Under the Skin"

  6. Brahms J. Piano Quartet No 1 in G minor, Op. 25 (orch. Schoenberg) / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Brahms J. Piano Quartet No 1 in G minor, Op. 25 (orch. Schoenberg). Variations and Fugue on a Theme by Händel, Op. 24 (orch, Rubbra). London Symphony Orchestra /Neeme Järvi" Chandos ABTD 1450; CD CHAN 8825 (71 minutes)

  7. Orchestral Programming 1982-1987: An Indication of Musical Taste.

    Science.gov (United States)

    Price, Harry E.

    1990-01-01

    Analyzes orchestral repertoire data as indications of musical taste. Collects data from 34 U.S. and Canadian symphony orchestras from 1982 through 1987. Summarizes and compares programing of 600 composers and 10,500 works. Reveals that Mozart was most frequently performed, and Beethoven was given most time. Shows relationship between student and…

  8. How Universal Is Beethoven?: Music, Culture, and Democracy

    Science.gov (United States)

    Whale, Mark

    2015-01-01

    Daniel Barenboim, conductor of the Arab/Israeli West-Eastern Divan Orchestra, claims that "everywhere in the world … [Beethoven's Ninth Symphony] speaks to all people." But just how universal is Beethoven? Does his music exceed cultural boundaries or is Barenboim's idea of a "utopian republic," built, in part, upon Beethoven's…

  9. A Rehearsal of a Beethoven Passage: An Analysis of Correction Talk.

    Science.gov (United States)

    Weeks, Peter

    1996-01-01

    Explores the detailed processes whereby concert performances of serious music are collectively achieved in rehearsal. The article concentrates on a youth orchestra rehearsing a section of a Beethoven symphony that was audiotaped. The article further focuses on the "talk" that shapes the collective musical activities rather than the…

  10. The American in Europe as Portrayed in American Literature of Late Nineteenth and Early Twentieth Centuries

    Science.gov (United States)

    1990-05-22

    Gradual Making Of The Making Of Americans," 257. 3 Stein, Narration, 6. 128 into one great rhythm. It is like a Beethoven symphony in that it consolidates...all of the little melodies into a great swelling and ebbing piece of music . I think that through her theories, Stein advocates the need of man to

  11. The Effect of Three Methods of Supporting the Double Bass on Muscle Tension.

    Science.gov (United States)

    Dennis, Allan

    1984-01-01

    Using different methods of holding the double bass, college students performed Beethoven's Symphony No. 9. Audio recordings of performance were rated. Muscle tension readings from the left arm, right arm, upper back, and lower back were taken, using electromyography. Results suggest nonsignificant differences in both performance quality and muscle…

  12. Questionnaire investigation of musicians’ use of hearing protectors, self reported hearing disorders and their experience of their working environment

    DEFF Research Database (Denmark)

    Laitinen, Heli; Poulsen, Torben

    2008-01-01

    Musicians in symphony orchestras are exposed to harmful sound levels. Although research shows that industrial workers have a higher propensity to noise induced hearing loss, musicians can also develop a hearing loss from noise exposure. Furthermore, musicians can suffer from tinnitus, hyperacusis...

  13. Towards Verification of Constituent Systems through Automated Proof

    DEFF Research Database (Denmark)

    Couto, Luis Diogo Monteiro Duarte; Foster, Simon; Payne, R

    2014-01-01

    This paper explores verification of constituent systems within the context of the Symphony tool platform for Systems of Systems (SoS). Our SoS modelling language, CML, supports various contractual specification elements, such as state invariants and operation preconditions, which can be used...

  14. Concerts & Opera

    Index Scriptorium Estoniae

    2008-01-01

    Kristjan Järvi dirigeerimas Vienna Tonkünstler Orchestra't 16. veebr. Leedsis Town Hallis (esitusel ka Arvo Pärdi Symphony No. 3), 20. veebr. Bristolis ja 23. veebr. Basingstoke'is. Neeme Järvi dirigeerimas Royal Scottish National Orcestra't 23. veebr. Glasgowis Royal Concert Hallis ja 24. veebr. Edinburghis Queens Hallis

  15. BRIDGING THE STRATEGIC TO OPERATIONAL GAP: AIR MOBILTY IN NATURAL DISASTER RELIEF

    Science.gov (United States)

    2016-06-01

    perfect location for a conveyor belt operation. Not the type of conveyor that produces bicycles or car engines, but one that conducts a symphony of...relatively successful track record of previous relief operations. Therefore, the question at hand is to determine where the benefit in planning can

  16. Shostakovich: Six Romances on Japanese Poems, Op. 21 / David Nice

    Index Scriptorium Estoniae

    Nice, David

    1996-01-01

    Uuest heliplaadist "Shostakovich: Six Romances on Japanese Poems, Op. 21. Six Poems of Marina Tsvetayeva, Op. 143. Suite on Verses of Michelangelo, Op. 145. Gothenburg Symphony Orchestra, Neeme Järvi. DG 447 085-2GH (71 minutes:DDD)

  17. Nederlandse muziek bij Nederlandse symfonieorkesten 1945-2000

    NARCIS (Netherlands)

    Overbeeke, E.

    2012-01-01

    Symphony orchestras play a crucial role in Dutch musical life. They not only give composers the opportunity to present their music and give musicians and listeners the chance to get acquainted with new music, they also have own ideas about presenting which music in which setting. This dissertation

  18. Tšaikovski, P. La Fille des neiges (musique de scene op. 12) / Serge Martin

    Index Scriptorium Estoniae

    Martin, Serge

    1995-01-01

    Uuest heliplaadist "Tšaikovski, P. La Fille des neiges (musique de scene op. 12). University Musical Society Choral Union. Detroit Symphony Orchestra, Neeme Järvi. Chandos CHAN 9324, distribution Media 7 (CD: 157 F). 1994. TT: 1h 19'04"

  19. World beyond Pluto

    CERN Document Server

    Marlowe, Stephen

    2014-01-01

    What happens when a hardened criminal on the run for his life gets mixed up with an all-girl symphony traveling between lesser-populated planets in a futile attempt to bring culture to their rowdy inhabitants? Well, to put it mildly, hijinks ensue. Read Stephen Marlowe's thoroughly entertaining World Beyond Pluto to find out the rest.

  20. The Economic Impact of Five Cultural Institutions on the Economy of the San Antonio SMSA.

    Science.gov (United States)

    Cwi, David

    The impact on the economy of five cultural institutions in the San Antonio, Texas, area was determined by measuring their 1978 direct and indirect financial effects. The institutions are the San Antonio Symphony, San Antonio Opera, Witte Museum, Museum of Transportation, and the Carver Cultural Center. Data gathered from the six institutions…

  1. The Economic Impact of Six Cultural Institutions on the Economy of the Columbus SMSA.

    Science.gov (United States)

    Cwi, David

    The impact of six cultural institutions on the Columbus, Ohio, economy was determined by measuring their 1978 direct and indirect financial effects. The six institutions are Ballet Metropolitan, Columbus Museum of Art, Columbus Symphony Orchestra, Center of Science and Industry, Players Theatre of Columbus, and Columbus Association for the…

  2. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 56; Issue 4. Volume 56, Issue 4. April 2001, pages 457-589 and C585-C587. pp 457-475 Review. The gravitational wave symphony of the Universe · B S Sathyaprakash · More Details Abstract Fulltext PDF. The new millennium will see the upcoming of several ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    . Special Issue on Emerging and Re-emerging Infections. pp 423-424. Foreword · C C Kartha U C Chaturvedi · More Details Fulltext PDF. pp 425-427. Combating emerging infectious diseases in India: Orchestrating a symphony · Lalit Kant.

  4. Muusikamaailm : Wien Modern 2001. "Taanit avastamas". Malcolm Arnold 80. Halina Czerny-Stefanska lahkunud / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    28.Xئ26.XI Wienis toimuvast nüüdismuusikafestivalist "Wien Modern". Birminghami Symphony Hallis korraldati kolmenädalane kontserdisari "Discover Denmark". Inglise helilooja, trompetisti ja dirigendi Malcolm Arnoldi 80. sünniaastapäevale pühendatud üritustest. Suri nimekas poola pianist Halina Czerny-Stefanska

  5. Nosferatu Pärnus

    Index Scriptorium Estoniae

    2004-01-01

    PÖFFi Suvekino raames algab mööda Eestit nn "Nosferatu tuur" ehk saksa tummfilmiklassika - Friedrich Wilhelm Murnau filmi "Nosferatu - õuduste sümfoonia" ("Nosferatu - Eine Symphonie des Grauens", 1921) ringreis koos ansambliga Kriminaalne Elevant (Kaspar Jancis, Danel Aljo, Eno Kollom, Hannes Kivi, Henry Tiisma)

  6. Kõlab õuduste sümfoonia / Kaupo Meiel

    Index Scriptorium Estoniae

    Meiel, Kaupo, 1975-

    2004-01-01

    PÖFFi Suvekino raames jõuab 11. juunil Pärnusse nn "Nosferatu tuur" ehk saksa tummfilmiklassika - Friedrich Wilhelm Murnau filmi "Nosferatu - õuduste sümfoonia" ("Nosferatu - Eine Symphonie des Grauens", 1921) ringreis koos ansambliga Kriminaalne Elevant (Kaspar Jancis, Danel Aljo, Eno Kollom, Hannes Kivi, Henry Tiisma)

  7. PÖFF-i suvekino : Nosferatu hirmufilmi show Katariina kirikus

    Index Scriptorium Estoniae

    2004-01-01

    PÖFFi Suvekino raames algab mööda Eestit nn "Nosferatu tuur" ehk saksa tummfilmiklassika - Friedrich Wilhelm Murnau filmi "Nosferatu - õuduste sümfoonia" ("Nosferatu - Eine Symphonie des Grauens", 1921) ringreis koos ansambliga Kriminaalne Elevant (Kaspar Jancis, Danel Aljo, Eno Kollom, Hannes Kivi, Henry Tiisma)

  8. Barber: Sinfonie Nr. 1, Op. 9, Neeme Järvi / Bernhard Uske

    Index Scriptorium Estoniae

    Uske, Bernhard

    1991-01-01

    Uuest heliplaadist "Barber: Sinfonie Nr. 1, Op. 9. Ouvertüre School for Scandal, Op. 5; Beach: Sinfonie e-Moll, Op. 32, "Gaelic". Detroit Symphony Orchestra /Neeme Järvi". Chandes cassette ABTD 1550; CD CHAN 8958 (72 minutes)

  9. Tobias, Rudolf: Jonah's Mission / Warrack, John

    Index Scriptorium Estoniae

    Warrack, John

    1996-01-01

    Uuest heliplaadist "Tobias, Rudolf: Jonah's Mission. Pille Lill (sop), Urve Tauts (mez), Peter Svensson (ten), Raimo Laukka (bar), Mati Palm (bass); Tallinn Boys' Choir, Estonian Philharmonic Chamber Choir, Oratorio Choir, Estonian State Symphony Orchestra, Neeme Järvi" BIS CD 731/2 (two discs: 114 minutes: DDD)

  10. Shostakovich: The Orchestral Songs Vol. 2 / Michael Tanner

    Index Scriptorium Estoniae

    Tanner, Michael

    1996-01-01

    Uuest heliplaadist "Shostakovich: The Orchestral Songs Vol. 2: Six Romances on texts by Japanese poets, Op. 21. Six Poems on Marina Tsvetayeva, Op. 143. Suite on Verses of Michelangelo, Op. 145. Gothenburg Symphony Orchestra, Neeme Järvi". DG 447 085-2GH (71 minutes:DDD)

  11. Teaching Artists and the Craft of Handmade Books

    Science.gov (United States)

    Weida, Courtney

    2015-01-01

    The work of teachers and literacy specialists has a lot of potential overlap with that of teaching artists of visual and literary arts within early childhood education. When young people in preschools and kindergartens practice early art and literacy, these two areas build in a sort of symphony as youngsters tell stories, make drawings of their…

  12. Musical Elements in the Performing Approach: Sonatina in C for Two Pianos from a Macedonian Contemporary Composer

    OpenAIRE

    Islam, Aida; Zelenkovska Leshkova, Stefanija

    2016-01-01

    Tomislav Zografski (1934–2000) is one of the representatives of the middle generation of modern Macedonian composers. He introduced into Macedonian art music the basic elements of neoclassicism. Zografski, in some of his works, develops this stylistic direction in the fields of chamber and symphony music.

  13. Fulltext PDF

    Indian Academy of Sciences (India)

    on Listening 10. Mahler's Ninth Symphony. ,. •. ~~. f~-~_' ~. ,. "

  14. Roussel. Sinfonien Nr. 3 g-Moll op. 42 und Nr. 4 A-Dur op. 5, Neeme Järvi / Christoph Schlüren

    Index Scriptorium Estoniae

    Schlüren, Christoph

    1995-01-01

    Uuest heliplaadist "Roussel. Sinfonien Nr. 3 g-Moll op. 42 und Nr. 4 A-Dur op. 53, Bacchus et Ariane op. 43 (Zweite Orchestersuite). Sinfonietta für Streichorchester d-Moll op. 52. Detroit Symphony Orchester, N. Järvi". Chandos/Koch CD 7007(WD: 70'10") DDD

  15. Towards a Transcultural Theory of Democracy for Instrumental Music Education

    Science.gov (United States)

    Tan, Leonard

    2014-01-01

    At present, instrumental music education, defined in this paper as the teaching and learning of music through wind bands and symphony orchestras of Western origin, appears embattled. Among the many criticisms made against instrumental music education, critics claim that bands and orchestras exemplify an authoritarian model of teaching that does…

  16. Penderecki: Konzert für Flöte und Kammerorchester; Eespere: Konzert für Flöte und Kammerorchester / Gero Schliess

    Index Scriptorium Estoniae

    Schliess, Gero

    1997-01-01

    Uuest heliplaadist "Penderecki: Konzert für Flöte und Kammerorchester; Eespere: Konzert für Flöte und Kammerorchester; Bartok: Suite paysanne hongroise für Flöte und Streichorchester. Estonian National Symphony Orchestra / Arvo Volmer". Signum/Note 1 CD X72-00 (WD:54'30")DDD

  17. The Art Institution in a Globalizing World

    NARCIS (Netherlands)

    Gielen, Pascal

    2010-01-01

    How do oclassicalo big art institutions (museums, the ballet, the opera, symphony orchestras) react to phenomena of globalization such as migration flows, the odenationalizationo of artistic movements, the enormous growth of the number of artists, the trend of a global cultural branding of cities,

  18. Fulltext PDF

    Indian Academy of Sciences (India)

    Ranchi 835215, India. How Many Birds are Unwatched. “Knowledge of a flute or a kettledrum is not sufficient to understand all the other instru- ments in a symphony orchestra or to predict their characteristics. Nor is knowledge of a single species, however complete, adequate for understanding diverse species. Diversity.

  19. Muusikamaailm : Tšehhi Filharmoonikud Ashkenazyga. Swansea festivali lõpetas Paavo Järvi. Steieri sügisfestivalilt. Ooperifestival Wexfordis / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    1999-01-01

    Tšehhi. Filh. Ork. kontserdireisist Inglismaale uue peadirigendi V.Ashkenazy juhatusel. Swansea sügisfestivalist Walesimaal. 23. okt. toimunud rahvusvahelisest Euroopa Ringhäälingute Liidu ooperiõhtu ülekandest Euroraadios. Uue muusika festivalist "Steirische Herbst" Austrias. Wexfordi ooperifestivalist Iirimaal/Tšehhi Filharmoonia Orkester//BBC Walesi Rahvusorkester//City of Birmingham Symphony Orchestra

  20. Valued Estonian Music CDs

    Index Scriptorium Estoniae

    2004-01-01

    2002. aastal välja antud eesti muusika heliplaatidest Artur Kapp "Symphonische Werke", Eduard Tubin "Symphonies No.9, No.10 and No.11", "Estonian Preludes", "Eesti heliloojad. Hortus Musicus", "Eesti Muusika Päevad", "Tallinn Saxophone Quartet. Estonian Contemporary Music", "Triskele. Kolga-Jaani vaimulikud rahvalaulud", "Helmekaala. Linnupuu Anne", "Modern Fox mängib Raimond Valgret",

  1. 26 CFR 1.513-1 - Definition of unrelated trade or business.

    Science.gov (United States)

    2010-04-01

    ... the school year, V sponsors the appearance of professional theater companies and symphony orchestras... operating a retail store and selling to the general public, where substantially all the work in carrying on... such organization contribute old clothes, books, furniture, et cetera, to be sold to the general public...

  2. The Story of Carora: The Origins of El Sistema

    Science.gov (United States)

    Carlson, Alexandra

    2016-01-01

    Venezuela's youth symphony program, the Fundación Musical Simón Bolívar, commonly referred to as "El Sistema," combines musical achievement with learning important life skills through orchestral practice and performance. Although the history most commonly reported outside Venezuela is of the program's director, José Antonio Abreu,…

  3. Things to Remember about El Sistema: A Response to "El Sistema--A Perspective for North American Music Educators" by Tricia Tunstall

    Science.gov (United States)

    Lesniak, Melissa

    2013-01-01

    Melissa Lesniak, the executive director of the Greater Miami Youth Symphony, discusses how much she enjoyed reading the responses to her "El Sistema" article and appreciates the opportunity for healthy dialogue and debate. In response, she states that there are many common goals and objectives across all music education programs that can…

  4. Mozartovský problém: proč nebyl hrán?

    Czech Academy of Sciences Publication Activity Database

    Jonášová, Milada; Volek, T.

    2016-01-01

    Roč. 23, č. 3 (2016), s. 44-47 ISSN 1210-8081 R&D Projects: GA ČR GAP409/12/2563 Institutional support: RVO:68378076 Keywords : symphony in G minor * KV 550 * Baron van Swieten * Johann Wenzel Subject RIV: AL - Art, Architecture, Cultural Heritage

  5. Analysis and modelling of flood risk assessment using information ...

    African Journals Online (AJOL)

    Floods are a serious hazard to life and property. The traditional probability statistical method is acceptable in analysing the flood risk but requires a large sample size of hydrological data. This paper puts forward a composite method based on artificial neural network (ANN) and information diffusion method (IDM) for flood ...

  6. Potentials of biological control of plant diseases in the tropics | Ofor ...

    African Journals Online (AJOL)

    This paper highlights the various categories of biological control, which are employed in an Integrated Disease Management (IDM) scheme. These include conservation, classical biocontrol and augmentation. Also, the various types of biocontrol agents/agencies which are currently in use in various parts of the world like, ...

  7. Population studies of fungal plant pathogens: Perspectives for ...

    African Journals Online (AJOL)

    Using grey leaf spot of maize (Cercospora zeae-maydis) as a case study, we show how these techniques can be used to generate information on genetic variability, providing for logical development of a durable IDM programme. Key words: Cercospora zeae-maydis, disease management, genetic tools, molecular markers

  8. Effect of culturally competent educational films about prenatal screening on informed decision making of pregnant women in the Netherlands.

    Science.gov (United States)

    Peters, I A; Posthumus, A G; Reijerink-Verheij, J C I Y; Van Agt, H M E; Knapen, M F C M; Denktaş, S

    2017-04-01

    To evaluate the effect of a culturally competent educational film (CCEF) on informed decision making (IDM) regarding prenatal screening (PS) in a study population consisting of multicultural pregnant women. A cross-sectional study with 262 women in the control group and 117 in the intervention group. All counselled participants received a self-report questionnaire to obtain data on IDM and only the intervention group received the CCEF. Twenty two percent of the study population had an ethnic minority background and 52% had a low or medium educational level. After exposure to the CCEF, knowledge about the Fetal Anomaly Scan (FAS) was significantly increased in ethnic minority women and in 'medium' and 'highly' educated women. Among women in the intervention group who had the intention to participate in FAS, there was an increase of 11% in IDM and a decrease of 12% in uninformed decision making. CCEF leads to a significant increase in the level of knowledge in medium and highly educated groups as well as non-western ethnic minority groups. The increase in IDM among intentional participants in the FAS is promising as well. CCEF's are a valuable complement to counseling about PS. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Modeling Method for Increased Precision and Scope of Directly Measurable Fluxes at a Genome-Scale

    DEFF Research Database (Denmark)

    McCloskey, Douglas; Young, Jamey D.; Xu, Sibei

    2016-01-01

    pathways of traditional MFA models and also covers the additional pathways of purine, pyrimidine, isoprenoid, methionine, riboflavin, coenzyme A, and folate, as well as other biosynthetic pathways. When evaluating the iDM2014 using a set of measured intracellular intermediate and cofactor mass isotopomer...

  10. Exploring an informed decision-making framework using in-home sensors: older adults’ perceptions

    Directory of Open Access Journals (Sweden)

    Jane Chung

    2014-03-01

    Full Text Available Background Sensor technologies are designed to assist independent living of older adults. However, it is often difficult for older adults to make an informed decision about adopting sensor technologies.Objective To explore Bruce’s framework of informed decision making (IDM for in-home use of sensor technologies in community-dwelling elders.Method The IDM framework guided development of a semi-structured interview. A theory-driven coding approach was used for analysis.Results Participants supported most of the elements of the framework, but not all aspects of each element were addressed. Perceived usefulness of technologies was identified as an area for framework extension.Conclusion This paper provides useful information for health care professionals to consider how to enhance IDM of older adults regarding the use of sensor technologies. The results also illuminate elements of the IDM framework that may be critical to facilitating independent living for older adults.

  11. Tank 241-AY-102 Leak Assessment Supporting Documentation: Miscellaneous Reports, Letters, Memoranda, And Data

    International Nuclear Information System (INIS)

    Engeman, J. K.; Girardot, C. L.; Harlow, D. G.; Rosenkrance, C. L.

    2012-01-01

    This report contains reference materials cited in RPP-ASMT -53793, Tank 241-AY-102 Leak Assessment Report, that were obtained from the National Archives Federal Records Repository in Seattle, Washington, or from other sources including the Hanford Site's Integrated Data Management System database (IDMS)

  12. Comparison of crack arrest methodologies

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    The ASTM Cooperative Test Program Data were used to compare the static (K/sub Ia/) and dynamic (K/sud ID/, K/sub IDm/) approaches to crack arrest. K/sub Ia/ is not dependent on K/sub Q/. This is consistent with the requirements of the static approach, but not the dynamic one which requires that K/sub Ia/ decrease with K/sub Q/ if K/sub ID/ (= K/sub IDm/) is a constant. K/sub ID/ increases systematically with K/sub Q/ at a rate that is consistent with calculations based on the use of a constant value for K/sub Ia/ which is equal to its measured mean value. Only in the limiting case of very short crack jumps (associated with very low average crack speeds) can K/sub ID/ be identified as a minimum value at which K/sub ID/ = K/sub IDm/. In this case K/sub IDm/ approx. K/sub Ia/ approx. K/sub Im/. The latter is the idealized minimum value of K that will support the continued propagation of a running crack

  13. Measuring consumers' information acquisition and decision behavior with the computer-based information-display-matrix

    DEFF Research Database (Denmark)

    Aschemann-Witzel, Jessica; Hamm, Ulrich

    2011-01-01

    prior to decisions reached in interviews or choice experiments. The contribution introduces to the method and its´ development, use and (dis-)advantages. Results of a survey illustrate the options for analysis and indicate that consumer behaviour in the IDM, compared to face-to-face-interviews, is less...

  14. A Methodolgy, Based on Analytical Modeling, for the Design of Parallel and Distributed Architectures for Relational Database Query Processors.

    Science.gov (United States)

    1987-12-01

    AFIT MPOA Architecture ........ ....................... 13 9. DIRECT Architecture ........ .......................... 14 - d 10. Teradata Ynet...commercially available database machines [28,59.1]. the Britton-Lee and Teradata machines. There have been other cormpanies announce database machines. such...Processors Figure 10. Teradata Ynet Architecture The Britton-Lee IDM-500 series database machine is the most well known and widelv used database machine

  15. 75 FR 79348 - TRICARE; Formerly Known as the Civilian Health and Medical Program of the Uniformed Services...

    Science.gov (United States)

    2010-12-20

    .... SUPPLEMENTARY INFORMATION: The final rule published on September 1, 1987 (52 FR 32992) set forth the basic... hierarchy logic was changed so the age split (age http://www.tricare.mil/drgrates for a complete crosswalk... Medical Education (IDME) plus a fixed dollar amount. Thus, for Fiscal Year 2011, in order for a case to...

  16. Tank 241-AY-102 Leak Assessment Supporting Documentation: Miscellaneous Reports, Letters, Memoranda, And Data

    Energy Technology Data Exchange (ETDEWEB)

    Engeman, J. K.; Girardot, C. L.; Harlow, D. G.; Rosenkrance, C. L.

    2012-12-20

    This report contains reference materials cited in RPP-ASMT -53793, Tank 241-AY-102 Leak Assessment Report, that were obtained from the National Archives Federal Records Repository in Seattle, Washington, or from other sources including the Hanford Site's Integrated Data Management System database (IDMS).

  17. Optimization of a Novel Oral Colon Delivery System of Indomethacin ...

    African Journals Online (AJOL)

    Optimization of a Novel Oral Colon Delivery System of Indomethacin Using Full Factorial Design. SA Afifi, WM Mandour, KA Elkhodairy. Abstract. Purpose: To develop and optimize indomethacin (IDM) matrix tablets for specific colon drug delivery. Methods: Indomethacin matrix tablets containing hydrogenated castor oil ...

  18. ITER ITA newsletter. No. 20, February-March 2005

    International Nuclear Information System (INIS)

    2005-03-01

    This issue of ITER ITA (ITER transitional Arrangements) newsletter contains concise information about ITER related activities including interview on the occasion of Academician E.P. Velikhov' 70th birthday conducted by Dr. Lev Golubbchikov, former ITER Contact Person of the Russian Federation and a new document management system of ITER called IDM (ITER Document Management), which supersedes the old IDoMS

  19. Intrinsically dynamic population models

    Directory of Open Access Journals (Sweden)

    Robert Schoen

    2005-03-01

    Full Text Available Intrinsically dynamic models (IDMs depict populations whose cumulative growth rate over a number of intervals equals the product of the long term growth rates (that is the dominant roots or dominant eigenvalues associated with each of those intervals. Here the focus is on the birth trajectory produced by a sequence of population projection (Leslie matrices. The elements of a Leslie matrix are represented as straightforward functions of the roots of the matrix, and new relationships are presented linking the roots of a matrix to its Net Reproduction Rate and stable mean age of childbearing. Incorporating mortality changes in the rates of reproduction yields an IDM when the subordinate roots are held constant over time. In IDMs, the birth trajectory generated by any specified sequence of Leslie matrices can be found analytically. In the Leslie model with 15 year age groups, the constant subordinate root assumption leads to reasonable changes in the age pattern of fertility, and equations (27 and (30 provide the population size and structure that result from changing levels of net reproduction. IDMs generalize the fixed rate stable population model. They can characterize any observed population, and can provide new insights into dynamic demographic behavior, including the momentum associated with gradual or irregular paths to zero growth.

  20. The past, present and future of records and archives management in ...

    African Journals Online (AJOL)

    Ngulup

    Namibia; Institute of Development Management (IDM); Makerere University in Uganda and. Zimbabwe Open University. There has also been a mushrooming of companies offering short courses in records and archives management. This recent development, although it is an indication of the recognition on the importance ...

  1. Infarctus du myocarde chez le Togolais : Facteurs de risque eyt ...

    African Journals Online (AJOL)

    Le diagnostic de l'infarctus du myocarde (IDM) chez les noirs n'est pas aisé. Effet l'électrocardiographie (ECG) présente souvent chez ces derniers, des atypies de repolarisation. Le dosage des enzymes cardiaques devient donc incontournable. Notre objectif est d'évaluer les facteurs de risque chez les malades Togolais ...

  2. A First Look on iMiner's Knowledge base and Detecting Hidden Hierarchy of Riyadh Bombing Terrorist Network

    DEFF Research Database (Denmark)

    Memon, Nasrullah

    2007-01-01

    of Investigative Data Mining (IDM). In addition, we present iMiner Information Harvesting System and describe how intelligence agencies could be benefited from detecting hierarchy in non-hierarchical terrorist networks.  In this paper we present results of detection of hidden hierarchy of Riyadh Bombing Terrorist...

  3. PROTEINS IN VACUO . A MORE EFFICIENT MEANS OF ...

    African Journals Online (AJOL)

    One experimental descriptor which gives a general overview of ionic structure is the orientationally-averaged collision cross section , which is obtained from ion drift mobility (IDM) and other kinds of measurements. In modelling protein structures in vacuo with molecular dynamics simulations, it is necessary to calculate for a ...

  4. Download this PDF file

    African Journals Online (AJOL)

    IDM. • Ophthalmia neonatorum. These diseases also occur in a background of poor environment and poor diet. Poor Eye Health Background. • Eye disease. • Poor environment. • Poor diet. PROFESSIONAL LEADERSHIP. Ophthalmologists have given professional leadership in their field through such organizations as the ...

  5. RECODE: Design and baseline results of a cluster randomized trial on cost-effectiveness of integrated COPD management in primary care

    NARCIS (Netherlands)

    A.L. Kruis (Annemarije); M.R.S. Boland (Melinde); C.H. Schoonvelde (Catharina H.); W.J.J. Assendelft (Willem); M.P.M.H. Rutten-van Mölken (Maureen); J. Gussekloo (Jacobijn); A. Tsiachristas (Apostolos); N.H. Chavannes (Nicolas)

    2013-01-01

    markdownabstract__Abstract__ Background: Favorable effects of formal pulmonary rehabilitation in selected moderate to severe COPD patients are well established. Few data are available on the effects and costs of integrated disease management (IDM) programs on quality of care and health status of

  6. Health literacy skills for informed decision making in colorectal cancer screening: Perceptions of screening invitees and experts

    NARCIS (Netherlands)

    Woudstra, Anke J.; Timmermans, Daniëlle R. M.; Uiters, Ellen; Dekker, Evelien; Smets, Ellen M. A.; Fransen, Mirjam P.

    2017-01-01

    The process of informed decision making (IDM) requires an adequate level of health literacy. To ensure that all individuals have equal opportunity to make an informed decision in colorectal cancer (CRC) screening, it is essential to gain more insight into which health literacy skills are needed for

  7. Cochrane corner: is integrated disease management for patients with COPD effective?

    NARCIS (Netherlands)

    Kruis, A.L.; Smidt, N.; Assendelft, W.J.; Gussekloo, J.; Boland, M.R.; Rutten-van Molken, M.P.; Chavannes, N.H.

    2014-01-01

    Patients with COPD experience respiratory symptoms, impairments of daily living and recurrent exacerbations. The aim of integrated disease management (IDM) is to establish a programme of different components of care (ie, self-management, exercise, nutrition) in which several healthcare providers

  8. RECODE: design and baseline results of a cluster randomized trial on cost-effectiveness of integrated COPD management in primary care

    NARCIS (Netherlands)

    Kruis, A.L.; Boland, M.R.; Schoonvelde, C.H.; Assendelft, W.J.J.; Rutten-van Molken, M.P.; Gussekloo, J.; Tsiachristas, A.; Chavannes, N.H.

    2013-01-01

    BACKGROUND: Favorable effects of formal pulmonary rehabilitation in selected moderate to severe COPD patients are well established. Few data are available on the effects and costs of integrated disease management (IDM) programs on quality of care and health status of COPD patients in primary care,

  9. Cochrane corner: Is integrated disease management for patients with COPD effective?

    NARCIS (Netherlands)

    A.L. Kruis (Annemarije); N. Smidt (Nynke); W.J.J. Assendelft (Willem); J. Gussekloo (Jacobijn); M.R.S. Boland (Melinde); M.P.M.H. Rutten-van Mölken (Maureen); N.H. Chavannes (Nicolas)

    2014-01-01

    markdownabstractPatients with COPD experience respiratory symptoms, impairments of daily living and recurrent exacerbations. The aim of integrated disease management (IDM) is to establish a programme of different components of care (ie, self-management, exercise, nutrition) in which several

  10. Identity Management Processes Automation

    Directory of Open Access Journals (Sweden)

    A. Y. Lavrukhin

    2010-03-01

    Full Text Available Implementation of identity management systems consists of two main parts, consulting and automation. The consulting part includes development of a role model and identity management processes description. The automation part is based on the results of consulting part. This article describes the most important aspects of IdM implementation.

  11. Cochrane corner : is integrated disease management for patients with COPD effective?

    NARCIS (Netherlands)

    Kruis, Annemarije L.; Smidt, Nynke; Assendelft, Willem J. J.; Gussekloo, Jacobijn; Boland, Melinde R. S.; Rutten-van Molken, Maureen; Chavannes, Niels H.

    2014-01-01

    Patients with COPD experience respiratory symptoms, impairments of daily living and recurrent exacerbations. The aim of integrated disease management (IDM) is to establish a programme of different components of care (ie, self-management, exercise, nutrition) in which several healthcare providers

  12. Investigation of cholesterol bias due to a matrix effect of external quality assurance samples: how true is your cholesterol method?

    Science.gov (United States)

    Pretorius, Carel J; Klingberg, Sandra; Johnson, Leslie; Park, Rodney; Wilgen, Urs; Ungerer, Jacobus P J

    2012-11-01

    Comparability of cholesterol measurement is clinically required and external quality assurance (EQA) programmes are important to verify the trueness of routine methods. We developed a gas chromatography-isotope dilution mass spectrometry (GC-IDMS) total cholesterol assay to investigate the cause of a suspected matrix-related negative bias with the Beckman Coulter enzymatic method discovered in an EQA programme. The GC-IDMS method was calibrated with certified reference material and verified against a secondary reference method. Bias between the GC-IDMS and Beckman Coulter methods was estimated according to Clinical and Laboratory Standards Institute (CLSI) protocol EP9-A2 with 40 clinical samples. At clinically important decision levels, no significant bias was demonstrated on patients' samples (all results within a ±3% limit). A matrix effect confined to the EQA material that affected the Beckman Coulter total cholesterol method was confirmed. The GC-IDMS method is suitable as a higher order total cholesterol method in a routine clinical laboratory. Matrix effects defeat the objectives of EQA schemes by preventing the verification of trueness. Given the importance of obtaining a true cholesterol result without systematic error, we recommend that EQA material without matrix effects should be used.

  13. First evidence of pre-Hispanic dentistry in South America - Insights from Cusco, Peru.

    Science.gov (United States)

    Ortiz, A; Torres Pino, E C; Orellana González, E

    2016-04-01

    Intentional dental modification (IDM) derived from archeological or ethnographic contexts has been extensively documented across the globe. Despite the wealth of information on IDM for personal ornamentation and ritualistic purposes, evidence of IDM for therapeutic reasons among early Native Americans is poorly known and limited to a handful of cases. We report two upper canines from two pre-Hispanic individuals dated to the Late Horizon Period from Cusco (Peru), each showing a conical perforation on its incisal surface. Analyses were performed using traditional radiography, computed tomography and scanning electron microscopy. The depth and symmetrical location of the perforations at the center of the crown suggest that these two teeth were artificially drilled, rather than affected by taphonomic factors. The poor oral health of the individuals, the location of the perforations on the incisal surface, and evidence of intentional manipulation of the pulp chambers (as supported by their overall morphology and presence of striations and deep marks along the walls of the perforations) provide a strong case for the occurrence of prehistoric dentistry in the New World. The two canine teeth reported here represent the first pre-Columbian examples of IDM likely performed to ameliorate a dental pathology (presumably associated with the infection of the dental pulp) found in Peru and in the rest of South America. Copyright © 2015 Elsevier GmbH. All rights reserved.

  14. Optimization of a Novel Oral Colon Delivery System of Indomethacin ...

    African Journals Online (AJOL)

    Purpose: To develop and optimize indomethacin (IDM) matrix tablets for specific colon drug delivery. Methods: Indomethacin matrix tablets containing hydrogenated castor oil (HCO), and pectin (PEC) were prepared by hot fusion method. A 32 full factorial design was used to investigate the combined effect of two ...

  15. Interface Finite Elements for the Analysis of Fracture Initiation and Progression

    Science.gov (United States)

    Ambur, Damodar R. (Technical Monitor); Johnson, Eric R.

    2003-01-01

    Progressive failure analyses (PFA) are important for the prediction of residual strength and damage tolerance of vehicle structures, and to predict the energy absorbing capability of vehicle structures under crash-type loads. Typically continuum damage mechanics (CDM) and fracture mechanics (FM) are the methods used for PFA. The method of interfacial damage mechanics (IDM) is used for PFA in this research. IDM has capabilities intermediate between CDM and FM, and is used to numerically model the initiation, growth, and arrest of cracks. IDM smooths the stress singularity at the crack tip, and is easily adaptable with other nonlinearties such as plasticity and material damage. IDM is implemented by user-defined interface elements in the ABAQUS/ Standard structural analysis software package. The structural components selected to demonstrate the effectiveness PFA using interface elements are, for the most part, those with published test data. These structural components were subjected to quasi-static loading in the tests. Thus, the ABAQUS analyses are used to predict geometrically and materially nonlinear equilibrium states. Impact loading, dynamic fracture, reflected stress waves, inertia, and time dependent material behavior are not considered.

  16. Comparative assessment of pest management practices in potato production at farmer field schools

    Science.gov (United States)

    Farmer field schools (FFS) and other participatory approaches are useful methods for rapid delivery of agricultural technologies in resource-constrained agro-ecosystems. Cultivar selection, weekly fungicide applications and integrated disease management (IDM) based on a disease monitoring strategy w...

  17. 76 FR 72912 - TRICARE; Civilian Health and Medical Program of the Uniformed Services (CHAMPUS); Fiscal Year...

    Science.gov (United States)

    2011-11-28

    ... productivity and less 0.1 percentage point for hospitals in all areas. However, these reductions do not apply... (wage adjusted) for the DRG plus the IDME payment plus $21,482 (wage adjusted). The marginal cost factor for cost outliers continues to be 80 percent. F. National Operating Standard Cost as a Share of Total...

  18. Modeling the economic impact of medication adherence in type 2 diabetes: a theoretical approach

    Directory of Open Access Journals (Sweden)

    David S Cobden

    2010-08-01

    Full Text Available David S Cobden1, Louis W Niessen2, Frans FH Rutten1, W Ken Redekop11Department of Health Policy and Management, Section of Health Economics – Medical Technology Assessment (HE-MTA, Erasmus MC, Erasmus University Rotterdam, The Netherlands; 2Department of International Health, Johns Hopkins University School of Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, USAAims: While strong correlations exist between medication adherence and health economic outcomes in type 2 diabetes, current economic analyses do not adequately consider them. We propose a new approach to incorporate adherence in cost-effectiveness analysis.Methods: We describe a theoretical approach to incorporating the effect of adherence when estimating the long-term costs and effectiveness of an antidiabetic medication. This approach was applied in a Markov model which includes common diabetic health states. We compared two treatments using hypothetical patient cohorts: injectable insulin (IDM and oral (OAD medications. Two analyses were performed, one which ignored adherence (analysis 1 and one which incorporated it (analysis 2. Results from the two analyses were then compared to explore the extent to which adherence may impact incremental cost-effectiveness ratios.Results: In both analyses, IDM was more costly and more effective than OAD. When adherence was ignored, IDM generated an incremental cost-effectiveness of $12,097 per quality-adjusted life-year (QALY gained versus OAD. Incorporation of adherence resulted in a slightly higher ratio ($16,241/QALY. This increase was primarily due to better adherence with OAD than with IDM, and the higher direct medical costs for IDM.Conclusions: Incorporating medication adherence into economic analyses can meaningfully influence the estimated cost-effectiveness of type 2 diabetes treatments, and should therefore be ­considered in health care decision-making. Future work on the impact of adherence on health

  19. Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032.

    Science.gov (United States)

    Ma, Liang; Zhang, Wenjun; Zhu, Yiguang; Zhang, Guangtao; Zhang, Haibo; Zhang, Qingbo; Zhang, Liping; Yuan, Chengshan; Zhang, Changsheng

    2017-08-01

    Tryptophan dimers (TDs) are an important class of natural products with diverse bioactivities and share conserved biosynthetic pathways. We report the identification of a partial gene cluster (spm) responsible for the biosynthesis of a class of unusual TDs with non-planar skeletons including spiroindimicins (SPMs), indimicins (IDMs), and lynamicins (LNMs) from the deep-sea derived Streptomyces sp. SCSIO 03032. Bioinformatics analysis, targeted gene disruptions, and heterologous expression studies confirmed the involvement of the spm gene cluster in the biosynthesis of SPM/IDM/LNMs, and revealed the indispensable roles for the halogenase/reductase pair SpmHF, the amino acid oxidase SpmO, and the chromopyrrolic acid (CPA) synthase SpmD, as well as the positive regulator SpmR and the putative transporter SpmA. However, the spm gene cluster was unable to confer a heterologous host the ability to produce SPM/IDM/LNMs. In addition, the P450 enzyme SpmP and the monooxygenase SpmX2 were found to be non-relevant to the biosynthesis of SPM/IDM/LNMs. Sequence alignment and structure modeling suggested the lack of key conserved amino acid residues in the substrate-binding pocket of SpmP. Furthermore, feeding experiments in the non-producing ΔspmO mutant revealed several biosynthetic precursors en route to SPMs, indicating that key enzymes responsible for the biosynthesis of SPMs should be encoded by genes outside of the identified spm gene cluster. Finally, the biosynthetic pathways of SPM/IDM/LNMs are proposed to lay a basis for further insights into their intriguing biosynthetic machinery.

  20. Oxidation of indometacin by ferrate (VI): kinetics, degradation pathways, and toxicity assessment.

    Science.gov (United States)

    Huang, Junlei; Wang, Yahui; Liu, Guoguang; Chen, Ping; Wang, Fengliang; Ma, Jingshuai; Li, Fuhua; Liu, Haijin; Lv, Wenying

    2017-04-01

    The oxidation of indometacin (IDM) by ferrate(VI) (Fe(VI)) was investigated to determine the reaction kinetics, transformation products, and changes in toxicity. The reaction between IDM and Fe(VI) followed first-order kinetics with respect to each reactant. The apparent second-order rate constants (k app ) decreased from 9.35 to 6.52 M -1  s -1 , as the pH of the solution increased from 7.0 to 10.0. The pH dependence of k app might be well explained by considering the species-specific rate constants of the reactions of IDM with Fe(VI). Detailed product studies using liquid chromatography-tandem mass spectrometry (LC-MS/MS) indicated that the oxidation products were primarily derived from the hydrolysis of amide linkages, the addition of hydroxyl groups, and electrophilic oxidation. The toxicity of the oxidation products was evaluated using the Microtox test, which indicated that transformation products exhibited less toxicity to the Vibrio fischeri bacteria. Quantitative structure-activity relationship (QSAR) analysis calculated by the ecological structure activity relationship (ECOSAR) revealed that all of the identified products exhibited lower acute and chronic toxicity than the parent pharmaceutical for fish, daphnid, and green algae. Furthermore, Fe(VI) was effective in the degradation IDM in water containing carbonate ions or fulvic acid (FA), and in lake water samples; however, higher Fe(VI) dosages would be required to completely remove IDM in lake water in contrast to deionized water.

  1. Decreased prostacyclin production in the infant of the diabetic mother

    International Nuclear Information System (INIS)

    Stuart, M.J.; Sunderji, S.G.; Allen, J.B.

    1981-01-01

    Maternal diabetes mellitus is recognized to be a predisposing factor to thrombosis in the neonate. In the adult with diabetes, abnormalities in the metabolism of AA by the platelet and vessel wall occur, which result in an increase in proaggregatory platelet thromboxane A2. A decrease in antiaggregatory vascular PGI2 has been demonstrated in the diabetic rat, although conclusive proof of a similar abnormality is lacking in humans. We evaluated vascular AA metabolism in 10 IDM (groups II and III comparison to 20 control neonates of gestational ages 32 to 40 weeks (group I). Mean uptakes of labeled AA into vascular tissue of both controls and IDM were similar. The conversion of [14C] AA to 6-keto-PGF1 alpha was not dependent on gestational age (r . 0.223) in the control neonates, with a mean value of 5.2% +- 1.3 (1 S.D.). A marked decrease (p less than 0.001) in 6-keto-PGF1 alpha formation to 1.7% +- 0.3 was found in the group II IDM of mothers with poor diabetic control (HbA1c . 9.3% +- 0.5). In the group III neonates whose mothers had normal HBA1c levels (6.1% +- 0.9), 6-keto-PGF1 alpha production was normal at 4.9% +- 0.8. Although no correlation between maternal fasting blood glucose and neonatal 6-keto-PGF1 alpha was demonstrable, a significant inverse correlation (r . 0.872; p less than 0.02) was observed between maternal HbA1c levels and the conversion of AA to 6-keto-PGF1 alpha in the vascular tissues of the IDM. It appear possible that abnormalities in platelet-vascular AA metabolism may play an etiologic role in the vascular complications present in some IDM

  2. Decreased prostacyclin production in the infant of the diabetic mother

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, M.J.; Sunderji, S.G.; Allen, J.B.

    1981-09-01

    Maternal diabetes mellitus is recognized to be a predisposing factor to thrombosis in the neonate. In the adult with diabetes, abnormalities in the metabolism of AA by the platelet and vessel wall occur, which result in an increase in proaggregatory platelet thromboxane A2. A decrease in antiaggregatory vascular PGI2 has been demonstrated in the diabetic rat, although conclusive proof of a similar abnormality is lacking in humans. We evaluated vascular AA metabolism in 10 IDM (groups II and III comparison to 20 control neonates of gestational ages 32 to 40 weeks (group I). Mean uptakes of labeled AA into vascular tissue of both controls and IDM were similar. The conversion of (14C) AA to 6-keto-PGF1 alpha was not dependent on gestational age (r . 0.223) in the control neonates, with a mean value of 5.2% +- 1.3 (1 S.D.). A marked decrease (p less than 0.001) in 6-keto-PGF1 alpha formation to 1.7% +- 0.3 was found in the group II IDM of mothers with poor diabetic control (HbA1c . 9.3% +- 0.5). In the group III neonates whose mothers had normal HBA1c levels (6.1% +- 0.9), 6-keto-PGF1 alpha production was normal at 4.9% +- 0.8. Although no correlation between maternal fasting blood glucose and neonatal 6-keto-PGF1 alpha was demonstrable, a significant inverse correlation (r . 0.872; p less than 0.02) was observed between maternal HbA1c levels and the conversion of AA to 6-keto-PGF1 alpha in the vascular tissues of the IDM. It appear possible that abnormalities in platelet-vascular AA metabolism may play an etiologic role in the vascular complications present in some IDM.

  3. Sinfonia e confessione. Forme letterarie e pitagorismo in José Vasconcelos e María Zambrano

    Directory of Open Access Journals (Sweden)

    Lorena Grigoletto

    2018-02-01

    With this objective, their reflection about the complex articulation and declination of the history of philosophy in literary genres, as places of its intimate drama, flows in the analysis of two specific and, in some respects, similar forms of literature: the symphony (Vasconcelos and the confession (Zambrano. The latter is nothing new in the literary scene but, recognized as true of Western thinking method, is proposed as a conditio sine qua non of its authentic rebirth. Symphony and confession, which in their analogical and musical process would realize the ancient Pythagorean inspiration, insist on the need to invalidate that world devoid of subject, to reveal the immobilism and the absolutism of the concept and to rethink the tragedy, as a genre and in its historical manifestations, to forestall its ending. They share, therefore, the same purpose: the fulfillment of an ‘ethical Hystory’.

  4. Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery.

    Science.gov (United States)

    Lee, Jae-Young; Termsarasab, Ubonvan; Lee, Mee Yeon; Kim, Dong-Hwan; Lee, Song Yi; Kim, Jung Sun; Cho, Hyun-Jong; Kim, Dae-Duk

    2017-07-15

    A chitosan oligosaccharide (CSO)-indomethacin (IDM) conjugate (CI) was synthesized to fabricate chemosensitizing nanoparticles (NPs) for tumor-targeted drug delivery. IDM was conjugated to a CSO backbone via amide bond formation, of which successful synthesis was confirmed by proton-nuclear magnetic resonance analyses. Doxorubicin (DOX)-loaded CI (CI10/DOX; CI:DOX=10:1 [w/w]) NPs with IDM increased in the presence of A549 cell lysates. In A549 cells (human lung carcinoma cells), more efficient cellular uptake of CI10/DOX NPs than that of free DOX was observed by using confocal laser scanning microscopy and flow cytometry. The in vitro cytotoxicity of CI10/DOX NPs in A549 cells was higher than those of free DOX and CI NPs with free DOX groups. In vivo pharmacokinetic studies after intravenous administration in rats showed significantly lower clearance of DOX from NPs compared with the free DOX group. Tumor targetability of the developed CI NPs was also verified by a real-time optical imaging study. In summary, the chemosensitizing CI/DOX NP with enhanced anticancer activity, prolonged blood circulation, and passive tumor targeting can be a promising anticancer drug delivery system for tumor-targeted therapy. Chemosensitizing nanoparticles (NPs) based on amphiphilic chitosan oligosaccharide-indomethacin (CSO-IDM; CI) conjugate were developed for tumor-targeted delivery of doxorubicin (DOX). IDM was introduced to the CSO backbone as a hydrophobic residue to synthesize an amphiphilic conjugate and a chemosenstizer of DOX for improving antitumor efficacies. IDM, conjugated to CSO, may inhibit the efflux of cellular uptaken DOX via multidrug resistance-associated protein (MRP) and subsequently augment the anti-proliferation potentials of DOX in A549 cells (MRP-expressed human lung cancer cells). Chemosensitizing properties of developed CI NPs were assessed in cell culture models and the tumor targetability of CI/DOX NPs was demonstrated in A549 tumor-xenografted mouse

  5. Introduction

    Science.gov (United States)

    Rossing, Thomas D.

    String instruments are found in almost all musical cultures. Bowed string instruments form the backbone of symphony orchestras, and they are used widely as solo instruments and in chamber music as well. Guitars are used universally in pop music as well as in classical music. The piano is probably the most versatile of all musical instruments, used widely not only in ensemble with other musical instruments but also as a solo instrument and to accompany solo instruments and the human voice.

  6. An Inventory Battery to Predict Performance in Navy Officer Recruiting: Development and Validation

    Science.gov (United States)

    1984-12-01

    with concurrent validation design ( Guion & Cranny, 1982), the results must be viewed as suggestive. It appears that the officer recruiter key can...Development Center. (AD-A069 37 1) Guion , R. M., & Cranny, C. 3. (1982). A note of concurrent and predictive validity designs: A critical reanalysis...with other people. T F 121. 1 like to listen to symphony orchestra concerts on the radio . B-21 SECTION 4 Most Descriptive Adjective List The purpose

  7. Again and Again and Again. Music as site, situation and repetition

    OpenAIRE

    Buene, Eivind

    2018-01-01

    Contents. - Introduction. - Excavation, Exhumation, Autopsy. The Symphony Orchestra as Site. - Body and Site. Reading Kwon, thinking of Gould. - Brief Note on Repetition. - Critical Music? A spanner in the works. - Brief Note on Infinite Endings. - Delirious Brahms. Investigating the music chamber. - Brief note on Hacktivism. - Posthumous Passions. A different perspective. - Brief Note on Transcription. - ‘Smart critiques. Stupid creates’, Part 1. - ‘Smart critiques. Stupid creates’, Part 2. ...

  8. European Science Notes Information Bulletin: Reports on Current European/Middle Eastern Science

    Science.gov (United States)

    1992-06-01

    vni uiteeaenweog ultew aers musicians to form two additional symphony orchestras. paper are: Israel is having a difficult time absorbing this large in... burnable waste along with conventional effects of Chemoble are remembered. Safety and envi- fuels. In Sweden, excess powerplant heat is used when...lenses, or fibers. Royal Signals and Radar Establishment (RSRE) and the The losses are calculated to be 1 dB/cm. U.K. Ministry of Defence laboratories

  9. Arts Management - marketingová strategie symfonického tělesa (Filharmonie mladých Praha)

    OpenAIRE

    Fröhlich, Vojtěch

    2009-01-01

    Goal of this diploma thesis is to create a marketing strategy of the Prague Youth Philharmonic symphony orchestra including marketing concept definition, audience research and marketing communication project. The marketing strategy proceeds from internal and external SWOT analysis of the subject. Theoretical part of the thesis deals with classical marketing theory and its use in arts management praxis. It focuses on strategic marketing and its instruments.

  10. ベートーヴェン《第9》解釈の系譜 : ハインリヒ・シェンカーの音楽物語を中心に

    OpenAIRE

    西田, 絋子; Nishida, Hiroko

    2011-01-01

    This paper discusses the interpretations of Beetoven's "Ninth Symophony" by Richard Wargner, Hermann Kretzschmar, and Heinrich Schenker, eithin the framework of a musical narrative. First, foundamental problems in musical narratology are discussed in order to bridge between recent studies and the narrative acts in Schenker's time. Second, Schenker's work "Beethoven's NInth Symphony" (1912) can be regarded as the starting point of this examination, because it includes a detailed criticism of t...

  11. Uus plaat

    Index Scriptorium Estoniae

    2004-01-01

    Uutest plaatidest Barry White "Love Songs", Charizma "Life in 3D", Toto Cutugno "il treno va...", "Talkin Loud 1990-1994", Delta Goodrem "Innocent Eyes", Astrud Gilberto "Astrud For Lovers", "Groove Is In The Heart", "The Last Samurai", Patricia Kaas "Sexe & Fort", Norah Jones "Feels Like Home", LeAnn Rimes "The Best Of", "Kumad Eesti hitid 2004", Thursday "War All The Time", Damageplan "New Found Power", Deep Purplr "Purpendicular", "Trance Allstars", Joseph Haydn "Symphonies 1-104", "Takorautaa", "DJ Esko. Setti2"

  12. A role of leader in creative schools

    Directory of Open Access Journals (Sweden)

    Мария Павловна Калашник

    2017-01-01

    Full Text Available A role of leader in the Jena «romantic school»; Mannheim school, which has prepared the emergence a classical form of symphony; Netherlands school with a main feature – composer's professionalism; Second Viennese School is examined in the article. The authority of these schools in the musical circles, comprehensive impact, fundamental meaning for becoming a composer’s art are marked. The creative, professionally-creative and technological aspect of schools are defined

  13. Optimal Volume for Concert Halls Based on Ando’s Subjective Preference and Barron Revised Theories

    Directory of Open Access Journals (Sweden)

    Salvador Cerdá

    2014-03-01

    Full Text Available The Ando-Beranek’s model, a linear version of Ando’s subjective preference theory, obtained by the authors in a recent work, was combined with Barron revised theory. An optimal volume region for each reverberation time was obtained for classical music in symphony orchestra concert halls. The obtained relation was tested with good agreement with the top rated halls reported by Beranek and other halls with reported anomalies.

  14. Music and Astronomy

    Science.gov (United States)

    Caballero, José A.; González Sánchez, S.; Caballero, I.

    What do Brian May (Queen's lead guitarist), William Herschel and the Jupiter Symphony have in common? And a white dwarf, a piano and Lagartija Nick? At first glance, there is no connection between them, nor between the Music and the Astronomy. However, there are many revealing examples of musical Astronomy and astronomical Music. This four-page proceeding describes the sonorous poster that we showed during the VIII Scientific Meeting of the Spanish Astronomical Society.

  15. Air-Sea Battle Concept: Back to the Future?

    Science.gov (United States)

    2012-04-23

    the interrogation techniques utilized at the Guantanamo detention facility, and concerns over the continuing policy of preemptive strikes against...amphibious doctrine was still in its infancy; the lessons on the tactics, techniques , and procedures required to gain access and conduct sustained...He was, in effect, conducting a symphony from the second violin section...What risks deserved his highest concern: the risk to the expeditionary

  16. Analysis of ROC on chest direct digital radiography (DR) after image processing in diagnosis of SARS

    Science.gov (United States)

    Lv, Guozheng; Lan, Rihui; Zeng, Qingsi; Zheng, Zhong

    2004-05-01

    The Severe Acute Respiratory Syndrome (SARS, also called Infectious Atypical Pneumonia), which initially broke out in late 2002, has threatened the public"s health seriously. How to confirm the patients contracting SARS becomes an urgent issue in diagnosis. This paper intends to evaluate the importance of Image Processing in the diagnosis on SARS at the early stage. Receiver Operating Characteristics (ROC) analysis has been employed in this study to compare the value of DR images in the diagnosis of SARS patients before and after image processing by Symphony Software supplied by E-Com Technology Ltd., and DR image study of 72 confirmed or suspected SARS patients were reviewed respectively. All the images taken from the studied patients were processed by Symphony. Both the original and processed images were taken into ROC analysis, based on which the ROC graph for each group of images has been produced as described below: For processed images: a = 1.9745, b = 1.4275, SA = 0.8714; For original images: a = 0.9066, b = 0.8310, SA = 0.7572; (a - intercept, b - slop, SA - Area below the curve). The result shows significant difference between the original images and processed images (P<0.01). In summary, the images processed by Symphony are superior to the original ones in detecting the opacity lesion, and increases the accuracy of SARS diagnosis.

  17. Isotope-dilution analyses of the metallic elements

    International Nuclear Information System (INIS)

    Chastagner, P.

    1982-01-01

    The isotope-dilution mass spectroscopy (IDMS) technique has proven to be to be a reliable, versatile analytical tool. Its applications seem to be limited only by the ingenuity of the investigator. Among its advantages are: small sample size; general applicability; precision and accuracy; dynamic range; simplified chemistry; determination is fixed at the time and place of isotopic homogenization. The last listed item is especially important for nuclear safeguards and processes where inventories are critical. IDMS is now a routine analytical technique in geochemical and nuclear laboratories, and in many environmental laboratories. Microgram and nanogram samples are normally used, frequently with automatic mass spectrometers, in many of these routine applications. More advanced techniques permit picogram and sub picogram samples to be analyzed, and spike to sample ratios can range from 1:1 to 1:10 12 with detection limits at attogram levels for some elements. 3 figures, 3 tables

  18. Prototype of Intrusion Detection Model using UML 5.0 and Forward Engineering

    Directory of Open Access Journals (Sweden)

    Muthaiyan MADIAJAGAN,

    2011-01-01

    Full Text Available In this paper we are using UML (Unified Modeling Language which is the blueprint language between the programmers, analysts, and designer’s for easy representation of pictures or diagrammatic notation with some textual data. Here we are using UML 5.0 to show “prototype of the Intrusion Detection Model” and by explaining it by combining various parts by drawing various UML diagrams such as Use cases and Activity diagrams and Class Diagram using which we show forward engineering using the class diagram of the IDM( Intrusion Detection Model. IDM is a device or software that works on detecting malicious activities by unauthorized users that can cause breach to the security policy within a network.

  19. Introducing E-Government in Developing Countries Analysis of Egyptian e-Government Services

    DEFF Research Database (Denmark)

    Elaswad, Othoman; Jensen, Christian D.

    2016-01-01

    Online Identification and Authentication is an essential requirement for providing e-services. Few studies have investigated the challenges facing e-Government and IDM in developing countries and, to the best of our knowledge, none of the existing research has studied the challenges facing online...... services that guarantee equal access to online services and an inclusive society. The study identifies strengths and weaknesses of the Egyptian e-Government and IDM services, which we believe are common to most NAC, since the NAC are quite similar in terms of social culture, citizen's education level...... and skills, citizen's behaviours, digital infrastructure and legislation, but also common to many other developing countries. Our analysis of the Egyptian e-Government services indicates that the security requirements and principle of equal access are not fully met, which illustrates the difficulty...

  20. Automated gravimetric sample pretreatment using an industrial robot for the high-precision determination of plutonium by isotope dilution mass spectrometry.

    Science.gov (United States)

    Surugaya, Naoki; Hiyama, Toshiaki; Watahiki, Masaru

    2008-06-01

    A robotized sample-preparation method for the determination of Pu, which is recovered by extraction reprocessing of spent nuclear fuel, by isotope dilution mass spectrometry (IDMS) is described. The automated system uses a six-axis industrial robot, whose motility is very fast, accurate, and flexible, installed in a glove box. The automation of the weighing and dilution steps enables operator-unattended sample pretreatment for the high-precision analysis of Pu in aqueous solutions. Using the developed system, the Pu concentration in a HNO(3) medium was successfully determined using a set of subsequent mass spectrometric measurements. The relative uncertainty in determining the Pu concentration by IDMS using this system was estimated to be less than 0.1% (k = 2), which is equal to that expected of a talented analyst. The operation time required was the same as that for a skilled operator.

  1. Total cholesterol in serum determined by isotope dilution/mass spectrometry, with liquid-chromatographic separation

    International Nuclear Information System (INIS)

    Takatsu, Akiko; Nishi, Sueo

    1988-01-01

    We describe an accurate, precise method for determination of total serum cholesterol by isotope dilution/mass spectrometry (IDMS) with liquid chromatographic separation. After adding [3,4- 13 C] cholesterol to serum and hydrolyzing the cholesterol esters, we extract the total cholesterol. High-performance liquid chromatography (HPLC) is used to separate the extracted cholesterol for measurement by electron-impact mass spectrometry with use of a direct-insertion device. To evaluate the specificity and the accuracy of this method, we also studied the conventional IDMS method, which involves converting cholesterol to the trimethylsilyl ether and assay by gas chromatography-mass spectrometry with use of a capillary column. The coefficient of variation for the HPLC method was a little larger than for the conventional method, but mean values by each method agreed within 1% for all sera tested. (author)

  2. Automated gravimetric sample pretreatment using an industrial robot for the high-precision determination of plutonium by isotope dilution mass spectrometry

    International Nuclear Information System (INIS)

    Surugaya, Naoki; Hiyama, Toshiaki; Watahiki, Masaru

    2008-01-01

    A robotized sample-preparation method for the determination of Pu, which is recovered by extraction reprocessing of spent nuclear fuel, by isotope dilution mass spectrometry (IDMS) is described. The automated system uses a six-axis industrial robot, whose motility is very fast, accurate, and flexible, installed in a glove box. The automation of the weighing and dilution steps enables operator-unattended sample pretreatment for the high-precision analysis of Pu in aqueous solutions. Using the developed system, the Pu concentration in a HNO 3 medium was successfully determined using a set of subsequent mass spectrometric measurements. The relative uncertainty in determining the Pu concentration by IDMS using this system was estimated to be less than 0.1% (k=2), which is equal to that expected of a talented analysis. The operation time required was the same as that for a skilled operator. (author)

  3. A National Identity Management Strategy to Enhance the Brazilian Electronic Government

    Directory of Open Access Journals (Sweden)

    José Alberto Sousa Torres

    2017-12-01

    Full Text Available Amongst the several problems with the Brazilian e-government services (e-Gov, many of them are related to the fact that Brazil does not have a National Strategy for Digital Identity Management (IdM. To design a  national strategy, it is crucial to analyze the solutions adopted in other countries and take into account Brazilian characteristics, such as its area, population, digital inclusion index, socio-political and economic profile, the current national identity registration system and the fraud rate. In this context, this paper aims to propose a national strategy for IdM for the Brazilian e-Gov program. This strategy was built upon by a literature review of the experiences of European countries and, mainly, the peculiarities inherent to Brazil.

  4. Thermal phase transition with full 2-loop effective potential

    Science.gov (United States)

    Laine, M.; Meyer, M.; Nardini, G.

    2017-07-01

    Theories with extended Higgs sectors constructed in view of cosmological ramifications (gravitational wave signal, baryogenesis, dark matter) are often faced with conflicting requirements for their couplings; in particular those influencing the strength of a phase transition may be large. Large couplings compromise perturbative studies, as well as the high-temperature expansion that is invoked in dimensionally reduced lattice investigations. With the example of the inert doublet extension of the Standard Model (IDM), we show how a resummed 2-loop effective potential can be computed without a high-T expansion, and use the result to scrutinize its accuracy. With the exception of Tc, which is sensitive to contributions from heavy modes, the high-T expansion is found to perform well. 2-loop corrections weaken the transition in IDM, but they are moderate, whereby a strong transition remains an option.

  5. Thermal phase transition with full 2-loop effective potential

    Directory of Open Access Journals (Sweden)

    M. Laine

    2017-07-01

    Full Text Available Theories with extended Higgs sectors constructed in view of cosmological ramifications (gravitational wave signal, baryogenesis, dark matter are often faced with conflicting requirements for their couplings; in particular those influencing the strength of a phase transition may be large. Large couplings compromise perturbative studies, as well as the high-temperature expansion that is invoked in dimensionally reduced lattice investigations. With the example of the inert doublet extension of the Standard Model (IDM, we show how a resummed 2-loop effective potential can be computed without a high-T expansion, and use the result to scrutinize its accuracy. With the exception of Tc, which is sensitive to contributions from heavy modes, the high-T expansion is found to perform well. 2-loop corrections weaken the transition in IDM, but they are moderate, whereby a strong transition remains an option.

  6. Single Thing Sign On Identity Management for Internet of Things

    DEFF Research Database (Denmark)

    Zdravkova, Vanya; Mihaylov, Mihail Rumenov; Mihovska, Albena Dimitrova

    2016-01-01

    —Within the context of heterogeneous Internet of Things (IoT) network driven by Machine-to-Machine (M2M) communications there is a need for a proper user identification and Identity Management (IdM) mechanisms which to involve all of the objects in the IoT. The paper addresses user identification...... by proposing Single Thing Sign On (STSO) IdM architecture for IoT, where the end-user is in the middle of a user-centered services ecosystem. The proposed scheme enables user recognition and services access only by identification of one of the “things” related to the user such as personal computing devices...

  7. Bifid tongue: a rare feature associated with infants of diabetic mother syndrome.

    Science.gov (United States)

    James, Aaron W; Culver, Kathy; Hall, Bryan; Golabi, Mahin

    2007-09-01

    Infants born to diabetic mothers (IDM) are well documented to have a higher rate of congenital malformations. Sacral agenesis/hypogenesis and caudal dysgenesis are classically linked to maternal diabetes, but many other types of anomalies are more frequent. In this case report, we describe a male infant born to a diabetic mother who in addition to other typical congenital abnormalities was born with an impressive bifid tongue. Accompanying congenital anomalies include unilateral microphthalmia, bilateral microtia, cleft palate, micropenis with unilateral cryptorchidism, bilateral radial hypoplasia, unilateral pre-axial polydactyly, and mid-line central nervous system defects including arhinencephaly and pituitary hypoplasia. Review of the literature reveals an additional case of an infant with a bifid tongue born to a diabetic mother [Comess et al., 1969]. In conclusion, bifid tongue without oral hamartoma, a rare congenital anomaly, can be an associated finding in IDM. Copyright 2007 Wiley-Liss, Inc.

  8. Methods for implementing Building Information Modeling and Building Performance Simulation approaches

    DEFF Research Database (Denmark)

    Mondrup, Thomas Fænø

    methodologies. Thesis studies showed that BIM approaches have the potential to improve AEC/FM communication and collaboration. BIM is by its nature multidisciplinary, bringing AEC/FM project participants together and creating constant communication. However, BIM adoption can lead to technical challenges......, for example, getting BIM-compatible tools to communicate properly. Furthermore, BIM adoption requires organizational change, that is changes in AEC/FM work practices and interpersonal dynamics. Consequently, to ensure that the adoption of BIM is successful, it is recommended that common IT regulations......, such as the Industry Foundation Classes (IFC), Information Delivery Manual (IDM), and Model View Definition (MVD), are proposed to provide clarification and consistency for BIM and BPS adoption, particularly, for BIM and BPS information exchange. As part of the thesis, a modular IDM Framework to define and organize...

  9. Analysis of frit by sodium peroxide fusion and flow injection analysis

    International Nuclear Information System (INIS)

    Walker, N.; Whitaker, M.

    1990-01-01

    Test runs for the immobilization of radioactive wastes in glass are now underway at the TNX Facility of the Savannah River Site. The wastes are immobilized by the Integrated Defense Waste Processing Facility Melter System (IDMS) process. The IDMS makes a borosilicate glass. To make the glass, certain quantities of boron and silicate must be maintained in the melter. The silicate is added to the melter in a substance called frit. To determine the amount of frit to add, it is necessary to calculate the percent silicate in the frit. The present method of determining the silicate content of frit has yielded inconsistent results. The focus of this project was to develop and implement a new process for determining the silicate content of frit. The author chose to achieve this goal using a colormetric method

  10. Certification of mercury in acrylonitrile butadiene styrene by using isotope dilution mass spectrometry

    International Nuclear Information System (INIS)

    Hu Hai; Ma Liandi; Wei Chao; Zhou Tao; Wang Jun; Zhao Motian; Li Jinying

    2008-01-01

    Under the framework of a co-certification system for the development of Certified Reference Materials (CRMs) among China, Japan and Korea, the 1st co-certification campaign of mercury in acrylonitrile butadiene styrene (ABS) for Japanese CRMs was taken. In this campaign isotope dilution mass spectrometry (IDMS) was used. First, all abundances of Hg in spike 202 Hg, CRM and ABS were analyzed by MC-ICP-MS before the certification. Then the concentrations of 202 Hg and Hg in ABS were determined with IDMS by Q-ICP-MS. A new procedure to reduce memory effect was used. first, dilute with 5 μg/g Au solution for 1 min; then, 5 μg/g EDTA solution for 2 min. The results accord to each other very well and this implies that the co-certification system can run swimmingly. (authors)

  11. NOVEL CONTEXT-AWARE CLUSTERING WITH HIERARCHICAL ADDRESSING (CCHA) FOR THE INTERNET OF THINGS (IoT)

    DEFF Research Database (Denmark)

    Mahalle, Parikshit N.; Prasad, Neeli R.; Prasad, Ramjee

    2013-01-01

    As computing technology becomes more tightly coupled into dynamic and mobile world of the Internet of Things (IoT), security mechanism becomes more stringent, less flexible and intrusive. Scalability issue in the IoT makes Identity Management (IdM) of ubiquitous things more challenging. Forming ad......-hoc network, interaction between these nomadic devices to provide seamless service extend the need of new identi-ties to the things, addressing and IdM in the IoT. New identities and identifier format to alleviate the perfor-mance issue is introduced in this paper. This paper pre-sents novel Context......-aware Clustering with Hierarchical Addressing (CCHA) scheme for the things with new identifier format. Simulation results shows that CCHA achieves better performance with less energy expendi-ture, less end-to-end delay and more throughput. Results also show that CCHA significantly reduces the failure probability...

  12. Approach for domestic preparation of standard material (LSD spike) for isotope dilution mass spectrometry

    International Nuclear Information System (INIS)

    Ishikawa, Fumitaka; Sumi, Mika; Chiba, Masahiko; Suzuki, Toru; Abe, Tomoyuki; Kuno, Yusuke

    2008-01-01

    The accountancy analysis of the nuclear fuel material at Plutonium Fuel Development Center of JAEA is performed by isotope dilution mass spectrometry (IDMS; Isotope Dilution Mass Spectrometry). IDMS requires the standard material called LSD spike (Large Size Dried spike) which is indispensable for the accountancy in the facilities where the nuclear fuel materials are handled. Although the LSD spike and Pu source material have been supplied from foreign countries, the transportation for such materials has been getting more difficult recently. This difficulty may affect the operation of nuclear facilities in the future. Therefore, research and development of the domestic LSD spike and base material has been performed at JAEA. Certification for such standard nuclear materials including spikes produced in Japan is being studied. This report presents the current status and the future plan for the technological development. (author)

  13. Telecommunications issues of intelligent database management for ground processing systems in the EOS era

    Science.gov (United States)

    Touch, Joseph D.

    1994-01-01

    Future NASA earth science missions, including the Earth Observing System (EOS), will be generating vast amounts of data that must be processed and stored at various locations around the world. Here we present a stepwise-refinement of the intelligent database management (IDM) of the distributed active archive center (DAAC - one of seven regionally-located EOSDIS archive sites) architecture, to showcase the telecommunications issues involved. We develop this architecture into a general overall design. We show that the current evolution of protocols is sufficient to support IDM at Gbps rates over large distances. We also show that network design can accommodate a flexible data ingestion storage pipeline and a user extraction and visualization engine, without interference between the two.

  14. Concrete and Rock Tests, Major Rehabilitation of Dresden Island Lock and Dam, Illinois Waterway, Chicago District. Phase II. Compliance, Scour Detection.

    Science.gov (United States)

    1981-03-01

    uwniin SHUAR STMSS AREA ________________________ URINO NO. GW-5 S AMPLE NO. DEPTH 33 OIRECT SHEAR TEST REPORT (ROCK) WES AR11490 EDITION oP JUNf4 SIs...28 " 24 -T2. 70 ILVAMO DRESDEN ISWIDM W)C AND DAM ANA *am* M E-1 ~N L15 .4-15.9/494.1-494.6 IDM2" FB7 NVJG WUCT SHUAR TT ROem -񓡌 (IM 10 1" IO-j Ml

  15. Automated input data management in manufacturing process simulation

    OpenAIRE

    Ettefaghian, Alireza

    2015-01-01

    Input Data Management (IDM) is a time consuming and costly process for Discrete Event Simulation (DES) projects. Input Data Management is considered as the basis of real-time process simulation (Bergmann, Stelzer and Strassburger, 2011). According to Bengtsson et al. (2009), data input phase constitutes on the average about 31% of the time of an entire simulation project. Moreover, the lack of interoperability between manufacturing applications and simulation software leads to a high cost to ...

  16. Patent landscape of neglected tropical diseases: an analysis of worldwide patent families

    OpenAIRE

    Akinsolu, Folahanmi Tomiwa; de Paiva, Vitor Nobre; Souza, Samuel Santos; Varga, Orsolya

    2017-01-01

    Background “Neglected Tropical Diseases” (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are “preventive chemotherapy and transmission control” (PCT), and “innovative and intensified disease management” (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the t...

  17. PENGEMBANGAN BUKU BERBASIS MULTI REPRESENTASI SERI FLUIDA DENGAN PENDEKATAN SAINS TEKNOLOGI DAN MASYARAKAT (STM)

    OpenAIRE

    Silaban, Kristin S; Delina, Mutia

    2017-01-01

    We have developed a multi-representative book for Fluids using Science Technology and Society approach. The content of this book represents in verbal, mathematic, graphic, and table forms. Fluids series book presented from basic knowledge to advanced knowledge. Research method that applied is Instructional Development Model (IDM) by Atwi Suparman with Educational research and development approach model consist of 9 stages. Legibility test has done to 5 students with result of content reach 81...

  18. Cardiac troponin I levels and its relation to echocardiographic findings in infants of diabetic mothers

    Directory of Open Access Journals (Sweden)

    Korraa Afaf

    2012-09-01

    Full Text Available Abstract Background Cardiomyopathy is noted in up to 40% of infants of diabetic mothers, and the exact mechanisms responsible for it are unknown. The aim of this study was to compare between infants of diabetic mothers (IDM and infants of non- diabetic mothers (INDM as regards cardiac troponin I (cTnI levels (as a marker of cardiac dysfunction and to examine the relationship between this marker and neonatal echocardiographic changes (cardiac structure and function. Methods A prospective, comparative study included eighty full term neonates during the first three days of life, during the period from April 2008 to June 2011. They were divided into 2 groups, group I: included 40 infants of diabetic mothers (IDMsand group II: included 40 infants of non diabetic healthy mothers as a control group. Results 37.5% of the IDMs were large for gestational age and demonstrated a significantly lower blood glucose level than the control group (34.6 ± 11.3mg/dl Vs 77.2 ± 19.8 mg/dl respectively , respiratory distress and cyanosis were the presenting signs in 67.5% of IDMs. Cardiac TnI on the second day of life increased significantly in infants of diabetic mothers in comparison to INDM (p (P-value = 0.002*. Cardiac TnI was significantly increased in IDMs with respiratory distress (P –value  Conclusions This study demonstrated a highly significant positive correlation between cTnI level on the second day of life and the left ventricular end diastolic diameter (LVED and interventricular septum diameter (IVSD. Cardiac troponin I (cTnI is a useful biochemical marker for monitoring myocardial injury in infants of diabetic mothers. An elevated cTnI concentration in infants of diabetic mothers with respiratory distress was a good predictor for hypertrophic cardiomyopathy and/or left ventricular dysfunction.

  19. Textural features of dynamic contrast-enhanced MRI derived model-free and model-based parameter maps in glioma grading.

    Science.gov (United States)

    Xie, Tian; Chen, Xiao; Fang, Jingqin; Kang, Houyi; Xue, Wei; Tong, Haipeng; Cao, Peng; Wang, Sumei; Yang, Yizeng; Zhang, Weiguo

    2017-08-28

    Presurgical glioma grading by dynamic contrast-enhanced MRI (DCE-MRI) has unresolved issues. The aim of this study was to investigate the ability of textural features derived from pharmacokinetic model-based or model-free parameter maps of DCE-MRI in discriminating between different grades of gliomas, and their correlation with pathological index. Retrospective. Forty-two adults with brain gliomas. 3.0T, including conventional anatomic sequences and DCE-MRI sequences (variable flip angle T1-weighted imaging and three-dimensional gradient echo volumetric imaging). Regions of interest on the cross-sectional images with maximal tumor lesion. Five commonly used textural features, including Energy, Entropy, Inertia, Correlation, and Inverse Difference Moment (IDM), were generated. All textural features of model-free parameters (initial area under curve [IAUC], maximal signal intensity [Max SI], maximal up-slope [Max Slope]) could effectively differentiate between grade II (n = 15), grade III (n = 13), and grade IV (n = 14) gliomas (P IDM, of four DCE-MRI parameters, including Max SI, Max Slope (model-free parameters), vp (Extended Tofts), and vp (Patlak) could differentiate grade III and IV gliomas (P IDM of Patlak-based K trans and vp could differentiate grade II (n = 15) from III (n = 13) gliomas (P IDM of Extended Tofts- and Patlak-based vp showed highest area under curve in discriminating between grade III and IV gliomas. However, intraclass correlation coefficient (ICC) of these features revealed relatively lower inter-observer agreement. No significant correlation was found between microvascular density and textural features, compared with a moderate correlation found between cellular proliferation index and those features. Textural features of DCE-MRI parameter maps displayed a good ability in glioma grading. 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017. © 2017 International Society for Magnetic Resonance in Medicine.

  20. Lake Bacterial Assemblage Composition Is Sensitive to Biological Disturbance Caused by an Invasive Filter Feeder

    OpenAIRE

    Vincent J. Denef; Hunter J. Carrick; Joann Cavaletto; Edna Chiang; Thomas H. Johengen; Henry A. Vanderploeg; Angela D. Kent

    2017-01-01

    ABSTRACT One approach to improve forecasts of how global change will affect ecosystem processes is to better understand how anthropogenic disturbances alter bacterial assemblages that drive biogeochemical cycles. Species invasions are important contributors to global change, but their impacts on bacterial community ecology are rarely investigated. Here, we studied direct impacts of invasive dreissenid mussels (IDMs), one of many invasive filter feeders, on freshwater lake bacterioplankton. We...

  1. Indomethacin nanocrystals prepared by different laboratory scale methods: effect on crystalline form and dissolution behavior

    Science.gov (United States)

    Martena, Valentina; Censi, Roberta; Hoti, Ela; Malaj, Ledjan; Di Martino, Piera

    2012-12-01

    The objective of this study is to select very simple and well-known laboratory scale methods able to reduce particle size of indomethacin until the nanometric scale. The effect on the crystalline form and the dissolution behavior of the different samples was deliberately evaluated in absence of any surfactants as stabilizers. Nanocrystals of indomethacin (native crystals are in the γ form) (IDM) were obtained by three laboratory scale methods: A (Batch A: crystallization by solvent evaporation in a nano-spray dryer), B (Batch B-15 and B-30: wet milling and lyophilization), and C (Batch C-20-N and C-40-N: Cryo-milling in the presence of liquid nitrogen). Nanocrystals obtained by the method A (Batch A) crystallized into a mixture of α and γ polymorphic forms. IDM obtained by the two other methods remained in the γ form and a different attitude to the crystallinity decrease were observed, with a more considerable decrease in crystalline degree for IDM milled for 40 min in the presence of liquid nitrogen. The intrinsic dissolution rate (IDR) revealed a higher dissolution rate for Batches A and C-40-N, due to the higher IDR of α form than γ form for the Batch A, and the lower crystallinity degree for both the Batches A and C-40-N. These factors, as well as the decrease in particle size, influenced the IDM dissolution rate from the particle samples. Modifications in the solid physical state that may occur using different particle size reduction treatments have to be taken into consideration during the scale up and industrial development of new solid dosage forms.

  2. Serum Creatinine: Not So Simple!

    OpenAIRE

    DELANAYE, Pierre; Cavalier, Etienne; Pottel, Hans

    2017-01-01

    Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDM...

  3. Research

    African Journals Online (AJOL)

    abp

    Key words: Complications respiratoires postopératoires, chirurgie de l'aorte, facteurs de risque. Received: ... le profil épidémiologique et déterminer les facteurs de risque des complications respiratoires dans notre contexte Méthodes: Il s'agit d'une étude de cohorte .... (IDM) répondait à la définition universelle de 2007 [6].

  4. Wrestling the Bear: The Rise of Russian Hybrid Warfare

    Science.gov (United States)

    2015-04-13

    search.proguest.com.nduezproxy.idm.oclc.orgldocview/1 545535275?accountid.:: J2686. (accessed on 4 December 2014). 14 Reuters, " Malaysia : Dutch...with subversive efforts. The aggressor often resorts to clandestine actions, to avoid attribution or retribution. Without a credible smoking gun, NATO...2015. Accessed December 27, 2014. http://www .nato.int/docu/review/20 14/ Also-in-20 14/Deterring-hybrid- warfare/EN/index .htm. Reuters,. ’ Malaysia

  5. Improved A1C Levels in Type 1 Diabetes with Smartphone App Use.

    Science.gov (United States)

    Ryan, Edmond A; Holland, Joanna; Stroulia, Eleni; Bazelli, Blerina; Babwik, Stephanie A; Li, Haipeng; Senior, Peter; Greiner, Russ

    2017-02-01

    Smartphones are a potentially useful tool in diabetes care. We have developed an application (app) linked to a website, Intelligent Diabetes Management (IDM), which serves as both an insulin bolus calculator and an electronic diabetes diary. We have prospectively studied whether patients using this app improved control of their glucose levels. Patients with type 1 diabetes were recruited. There was a 4-week observation period, midway during which we offered to review the participants' records. The app was then downloaded and participants' diabetes regimens entered on the synchronized IDM website. At 2, 4, 8, 12 and 16 weeks of the active phase, their records were reviewed online, and feedback was provided electronically. The primary endpoint was change in levels of glycated hemoglobin (A1C). Of the 31 patients recruited, 18 completed the study. These 18 made 572±98 entries per person on the IDM system over the course of the study (≈5.1/day). Their ages were 40.0±13.9 years, the durations of their diabetes were 27.3±14.9 years and 44% used insulin pumps. The median A1C level fell from 8.1% (7.5 to 9.0, IQ range) to 7.8% (6.9 to 8.3; p<0.001). During the observation period, glucose records were reviewed for 50% of the participants. In the active phase, review of the glucose diaries took less time on the IDM website than using personal glucose records in the observation period, median 6 minutes (5 to 7.5 IQ range) vs. 10 minutes (7.5 to 10.5 IQ range; p<0.05). Our smartphone app enables online review of glucose records, requires less time for clinical staff and is associated with improved glucose control. Copyright © 2016 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

  6. Enhancing Army S&T Lessons from Project Hindsight Revisited

    Science.gov (United States)

    2007-01-01

    34 Gregory N. Vigilante and Christopher P. Mulligan , “Cylindrical Magnetron Sputtering (CMS) of Coatings for Wear Life...analyzes radar emissions from potential targets. • The Improved Data Modem (IDM) permits the Apache to digitally communicate crucial threat...housing was originally made of aluminum. In 1999, the aluminum was replaced with a 17–layer carbon resin fiber composite [CTE 21]. This saved some weight

  7. Antioxidant Enzymes and Certain Trace Elements Values in Infants of Diabetic Mothers

    International Nuclear Information System (INIS)

    Al-Kady, M.M.; Al-Maghraby, D.F.; Mohammed, S.K.; Anees, L.M.

    2011-01-01

    Oxidative stress and accumulation of oxygen free radicals is a pathophysiological process leading to disadvantageous outcomes in diabetic pregnancies. Diabetes in pregnancy increases perinatal morbidity and mortality of both mother and her newborn. This study aimed to gain a view of antioxidant defense in the blood of infants of diabetic mothers (IDMs) and to clarify the relation among serum copper (Cu), Zinc (Zn), Selenium (Se) and antioxidant enzymes in these infants. For this reason, 25 infants of diabetic mothers (IDMs) were investigated. Twenty five newborns of healthy mothers served as a control group. Anthropometric and clinical evaluations were assessed in both groups. Laboratory investigations were performed including complete blood picture, direct and total bilirubin, serum Cu, Zn and Se. Erythrocyte superoxide dismutase (E-SOD)and erythrocyte glutathione peroxidase (E-GSHPx) were assisted. This study displayed highly significant reduction in levels of E-SOD and E-GSHPx in IDMs and in the mean serum levels of Cu, Zn and Se as compared to controls. There was a negative significant correlation between serum Zinc and blood glucose, there was a positive correlation between serum copper concentration and both gestational age and length. It also showed a significant positive correlation between GSHPx and both gestational age and Apgar 1, and a significant positive correlation between E-SOD, Apgar 1 and Apgar 5. These results proved that there is a state of oxidative stress in IDMs, therefore, their oxidant and antioxidant status should be carefully considered and appropriate management should be organized during the pregnancy and in the early postnatal period, including antioxidant and micro nutrients supplementation

  8. Application of a Gas Chromatography/Mass Spectrometric Method for the Determination of Butyltin Compounds in Sediment

    International Nuclear Information System (INIS)

    Chung, Min Young; Kim, Byung Joo; Yim, Yong Heon; So, Hun Young; Won, Yong Il; Jung, Pyong Gil; Kim, Yong Seong

    2004-01-01

    A gas chromatography/mass spectrometric (GC/MS) method has been developed for the determination of trace mono-n-butyltin (MBT), di-n-butyltin (DBT), and tri-n-butyltin (TBT) compounds in sediments. Samples were extracted by 10% acetic acid in methanol containing 0.03% tropolone and were then derivatized for GC/MS analysis. Ethylation by sodium tetraethylborate and phenylation by sodium tetraphenylborate were evaluated as a derivatization reaction of the organotins in sample extract. n-Hexane was added into reaction media in the beginning of the reaction for the continuous extraction of derivatized organotins. Ethylation requires less than 2 hours to get proper derivatization yields for MBT, DBT, and TBT altogether and produces relatively low amounts of side reaction products. Compared to ethylation, phenylation requires much longer time but provides relatively lower yield and produces considerable amounts of side reaction products. Therefore, the ethylation reaction was applied for the analysis of organotin compounds in sediment. An isotope dilution mass spectrometric (IDMS) method based on GC/MS has been applied to the accurate determination of DBT compounds in the sediments. The IDMS results from the analyses of sediment samples showed a reasonable repeatability and a good agreement with the values obtained by IDMS based on liquid chromatography/induced coupled plasma/mass spectrometry

  9. Semiconductor foundry, lithography, and partners

    Science.gov (United States)

    Lin, Burn J.

    2002-07-01

    The semiconductor foundry took off in 1990 with an annual capacity of less than 0.1M 8-inch-equivalent wafers at the 2-mm node. In 2000, the annual capacity rose to more than 10M. Initially, the technology practiced at foundries was 1 to 2 generations behind that at integrated device manufacturers (IDMs). Presently, the progress in 0.13-mm manufacturing goes hand-in-hand with any of the IDMs. There is a two-order of magnitude rise in output and the progress of technology development outpaces IDMs. What are the reasons of the success? Is it possible to sustain the pace? This paper shows the quick rise of foundries in capacity, sales, and market share. It discusses the their uniqueness which gives rise to advantages in conjunction with challenges. It also shows the role foundries take with their customer partners and supplier partners, their mutual dependencies, as well as expectations. What role then does lithography play in the foundries? What are the lithographic challenges to sustain the pace of technology? The experience of technology development and transfer, at one of the major foundries, is used to illustrate the difficulties and progresses made. Looking into the future, as semiconductor manufacturing will become even more expensive and capital investment more prohibitive, we will make an attempt to suggest possible solutions.

  10. Exploring the Inert Doublet Model through the dijet plus missing transverse energy channel at the LHC

    Directory of Open Access Journals (Sweden)

    P. Poulose

    2017-02-01

    Full Text Available In this study of the Inert Doublet Model (IDM, we propose that the dijet + missing transverse energy channel at the Large Hadron Collider (LHC will be an effective way of searching for the scalar particles of the IDM. This channel receives contributions from gauge boson fusion, and t-channel production, along with contributions from H+ associated production. We perform the analysis including study of the Standard Model (SM background with assumed systematic uncertainty, and optimise the selection criteria employing suitable cuts on the kinematic variables to maximise the signal significance. We find that with high luminosity option of the LHC, this channel has the potential to probe the IDM in the mass range of up to about 400 GeV, which is not accessible through other leptonic channels. In a scenario with light dark matter of mass about 65 GeV, charged Higgs in the mass range of around 200 GeV provides the best possibility with a signal significance of about 2σ at an integrated luminosity of about 3000 fb−1.

  11. Evaluation in situ digestibility of alfalfa in different grinds and textiles

    Directory of Open Access Journals (Sweden)

    Frank Akiyoshi Kuwahara

    2016-01-01

    Full Text Available Indigestible fractions of dry matter (iDM and neutral detergent fiber (iNDF in the feed of ruminants are mainly estimated by in situ incubation time with regard to particle size and textile types. Samples of alfafa, ground into three particle sizes, were analyzed. Samples, processed in a Willey mill with 1.0; 2.0 and 3.0 mm sieve pores, were conditioned in F57 (Ankon®, nonwoven (100 g m-2 and polyester textile bags measuring 4 x 5 cm. Material was divided into 13 incubation periods and 8 replications, and incubated in the rumen of two multiparous cows adapted to a 70:30 diet, roughage:concentrate, respectively, for 288h. iDM and iNDF rates were evaluated sequentially for non-digested percentage and data underwent analysis of variance (ANOVA p < 0.05; means were compared by tukey’s test (p < 0.05. Particle size and material employed for incubation affected iDM and iFDN at the initial periods of incubation (p < 0.05.

  12. Classical scale invariance in the inert doublet model

    Energy Technology Data Exchange (ETDEWEB)

    Plascencia, Alexis D. [Institute for Particle Physics Phenomenology, Department of Physics,Durham University, Durham DH1 3LE (United Kingdom)

    2015-09-04

    The inert doublet model (IDM) is a minimal extension of the Standard Model (SM) that can account for the dark matter in the universe. Naturalness arguments motivate us to study whether the model can be embedded into a theory with dynamically generated scales. In this work we study a classically scale invariant version of the IDM with a minimal hidden sector, which has a U(1){sub CW} gauge symmetry and a complex scalar Φ. The mass scale is generated in the hidden sector via the Coleman-Weinberg (CW) mechanism and communicated to the two Higgs doublets via portal couplings. Since the CW scalar remains light, acquires a vacuum expectation value and mixes with the SM Higgs boson, the phenomenology of this construction can be modified with respect to the traditional IDM. We analyze the impact of adding this CW scalar and the Z{sup ′} gauge boson on the calculation of the dark matter relic density and on the spin-independent nucleon cross section for direct detection experiments. Finally, by studying the RG equations we find regions in parameter space which remain valid all the way up to the Planck scale.

  13. Pilot study on real-time motion detection in UAS video data by human observer and image exploitation algorithm

    Science.gov (United States)

    Hild, Jutta; Krüger, Wolfgang; Brüstle, Stefan; Trantelle, Patrick; Unmüßig, Gabriel; Voit, Michael; Heinze, Norbert; Peinsipp-Byma, Elisabeth; Beyerer, Jürgen

    2017-05-01

    Real-time motion video analysis is a challenging and exhausting task for the human observer, particularly in safety and security critical domains. Hence, customized video analysis systems providing functions for the analysis of subtasks like motion detection or target tracking are welcome. While such automated algorithms relieve the human operators from performing basic subtasks, they impose additional interaction duties on them. Prior work shows that, e.g., for interaction with target tracking algorithms, a gaze-enhanced user interface is beneficial. In this contribution, we present an investigation on interaction with an independent motion detection (IDM) algorithm. Besides identifying an appropriate interaction technique for the user interface - again, we compare gaze-based and traditional mouse-based interaction - we focus on the benefit an IDM algorithm might provide for an UAS video analyst. In a pilot study, we exposed ten subjects to the task of moving target detection in UAS video data twice, once performing with automatic support, once performing without it. We compare the two conditions considering performance in terms of effectiveness (correct target selections). Additionally, we report perceived workload (measured using the NASA-TLX questionnaire) and user satisfaction (measured using the ISO 9241-411 questionnaire). The results show that a combination of gaze input and automated IDM algorithm provides valuable support for the human observer, increasing the number of correct target selections up to 62% and reducing workload at the same time.

  14. O DESENVOLVIMENTO E AS DESIGUALDADES NOS MUNICÍPIOS MARANHENSES: do desenvolvimentismo ao neodesenvolvimentismo.

    Directory of Open Access Journals (Sweden)

    Ana Maria Aquino dos Anjos Ottati

    2013-01-01

    Full Text Available O artigo apresenta uma análise sobre o nível de desenvolvimento dos municípios maranhenses a partir do cálculo do Índice de Desenvolvimento Municipal (IDM para os anos de 1980, 1991, 2000 e 2010. Busca verificar os resultados dos diversos projetos de desenvolvimento implantados no Estado impulsionados pelo padrão econômico vigente na época e que exigiram graus diferentes de participação do Estado e de capital de multinacionais. A pesquisa foi referente aos dados dos 217 municípios maranhenses e considerou cinco dimensões e 28 variáveis que serviram de base para o cálculo do IDM. Os resultados mostraram que houve melhora em todas as dimensões analisadas, o que resultou na melhoria de desenvolvimento de todos os municípios. Entretanto, comparando os valores médios do IDM de 1980 e 2010, foram observadas pequenas variações e, até mesmo, estagnação, tanto que em 2010, 83% dos municípios maranhenses ainda apresentavam nível muito baixo, baixo e médio de desenvolvimento.

  15. Does the selection of medicinal plants by Brazilian local populations suffer taxonomic influence?

    Science.gov (United States)

    deMedeiros, Patrícia Muniz; Ladio, Ana Haydée; Santos, André Maurício Melo; de Albuquerque, Ulysses Paulino

    2013-04-19

    The analysis of the influence of taxonomic affiliation on the selection of medicinal plants by Brazilian local populations can help elucidate theoretical aspects of medicinal plant selection. Ethnobotanical medicinal plant studies were compiled and the resulting medicinal flora was compared to the total angiosperm flora with a Bayesian approach and the IDM model. A total of 35 families were considered to be overused and six were classified as underused for the Bayesian approach. On the other hand, the IDM model considered 13 families as overused and five as underused (all of them were also highlighted by the Bayesian approach). A high overuse level of Bixaceae, Amaranthaceae, Anacardiaceae and Smilacaceae was recorded for both Bayesian and IDM model, while Orchidaceae, Melastomataceae, Eriocaulaceae, Poaceae and Bromeliaceae were considered as underused for both analyses. The most dissimilar body system in terms of family composition was 'mental and behavioral disorders'. It was also found that the body systems are different from one another in the proportion of taxonomic groups, which could indicate chemical specificity in the treatment of diseases. Results indicate that the chemical specificity of taxonomic groups directly influences medicinal plant selection. Moreover, when data presented here are compared to other studies, there is clearly an overuse pattern for families like Lamiaceae, Rosaceae and Euphorbiaceae and an underuse pattern for Poaceae and Orchidaceae. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  16. Online determination of copper in aluminum alloy by microchip solvent extraction using isotope dilution ICP-MS method.

    Science.gov (United States)

    Kagawa, Tsuyoshi; Ohno, Masashi; Seki, Tatsuya; Chikama, Katsumi

    2009-09-15

    Isotope dilution mass spectroscopy (IDMS)/ICP-MS combined with microchip solvent extraction was successfully applied for the online determination of copper in an aluminum alloy. The microchip solvent extraction was developed for the separation of Cu from major element, and optimal pH range was wider than that of the batchwise extraction method. The dimensions of the microchip were 30 mm x 70 mm and that of micro-channel on the microchip was 180 microm wide and 40 microm deep. The copper complex with 8-hydroxyquinoline was extracted into o-xylene at pH 5.5 and back extracted with 0.1 mol l(-1) nitric acid at flow rate of 20 microl min(-1). The total extraction efficiency (water/organic solvent/nitric acid) was around 40%. IDMS/ICP-MS was coupled with solvent extraction for precise determination of Cu. The extraction and back-extraction on the microchip took about 1s and the total measurement time for the IDMS/ICP-MS was about 40s/sample. The blank value of this method was 0.1 ng g(-1). The proposed method was used for the determination of Cu in Al standard materials (JSAC 0121-C, The Japan Society for Analytical Chemistry and 7074 Al alloy, Nippon Light Metal Co. Ltd.). The obtained analytical results are in good agreement with the certified values.

  17. Estimates of in situ digestibility and fibrous compounds in feeds for ruminants

    Directory of Open Access Journals (Sweden)

    Frank Akiyoshi Kuwahara

    2015-08-01

    Full Text Available Current paper assesses the relationship between in situ incubation time, particle size and types of materials on estimates of indigestible fractions of dry matter (iDM and neutral detergent fiber (iNDF in cattle feed and feces. Samples of soybean meal, alfalfa and feces of cattle fed on high concentrated diets were analyzed. The samples were processed in a Wiley mill, with 0.5 and 1.5 mm porosity for food and 1.5 mm for feces, which were packed in 4 × 5 cm F57 bags (Ankon® and nonwoven fabric (100 g m-2 of two brands. The material was divided into two groups, with and without treatment with acetone, and five replications. Samples of each group were incubated in the rumen of a multiparous cow adapted to a 70:30 diet, forage:concentrate diet, for 240 hours. The iDM and iNDF levels were evaluated sequentially to interpret the percentages of undigested material. Data underwent analysis of variance (ANOVA, p < 0.05 and means were compared by Tukey’s test (p < 0.05. Material, size of particles and incubated material affected iDM and iNDF estimates.

  18. Application of isotope dilution method for measuring bioavailability of organic contaminants sorbed to dissolved organic matter (DOM)

    Energy Technology Data Exchange (ETDEWEB)

    Delgado-Moreno, Laura, E-mail: laura.delgado@eez.csic.es; Wu, Laosheng; Gan, Jay

    2015-08-15

    Natural waters such as surface water and sediment porewater invariably contain dissolved organic matter (DOM). Association of strongly hydrophobic contaminants (HOCs) with DOM leads to decreased toxicity and bioavailability, but bioavailability of DOM-sorbed HOCs is difficult to measure. Current methods to estimate bioavailability of HOCs in water are based on only the freely dissolved concentration (C{sub free}). The ignorance of the exchangeable fraction of HOCs sorbed on DOM may result in an underestimation of the toxicity potential of HOCs to aquatic organisms. Here we explore the applicability of an isotope dilution method (IDM) to measuring the desorption fraction of DOM-sorbed pyrene and bifenthrin and determining their exchangeable pool (E) as an approximation of bioavailability. E values, expressed as percentage of the total concentration, ranged between 0.80 and 0.92% for pyrene and 0.74 and 0.85% for bifenthrin, depending primarily on the amount of chemical in the freely dissolved form. However, between 34 and 78% of the DOM-sorbed pyrene was exchangeable. This fraction ranged between 23% and 82% for bifenthrin. The ability of IDM to predict bioavailability was further shown from a significant relationship (r{sup 2} > 0.72, P < 0.0001) between E and bioaccumulation into Daphnia magna. Therefore, IDM may be used to improve the bioavailability measurement and risk assessment of HOCs in aquatic systems.

  19. Inelastic dark matter, non-standard halos and the DAMA/LIBRA results

    International Nuclear Information System (INIS)

    March-Russell, John; McCabe, Christopher; McCullough, Matthew

    2009-01-01

    The DAMA collaboration have claimed to detect particle dark matter (DM) via an annual modulation in their observed recoil event rate. This appears to be in strong disagreement with the null results of other experiments if interpreted in terms of elastic DM scattering, while agreement for a small region of parameter space is possible for inelastic DM (iDM) due to the altered kinematics of the collision. To date most analyses assume a simple galactic halo DM velocity distribution, the Standard Halo Model, but direct experimental support for the SHM is severely lacking and theoretical studies indicate possible significant differences. We investigate the dependence of DAMA and the other direct detection experiments on the local DM velocity distribution, utilizing the results of the Via Lactea and Dark Disc numerical simulations. We also investigate effects of varying the solar circular velocity, the DM escape velocity, and the DAMA quenching factor within experimental limits. Our data set includes the latest ZEPLIN-III results, as well as full publicly available data sets. Due to the more sensitive dependence of the inelastic cross section on the velocity distribution, we find that with Via Lactea the DAMA results can be consistent with all other experiments over an enlarged region of iDM parameter space, with higher mass particles being preferred, while Dark Disc does not lead to an improvement. A definitive test of DAMA for iDM requires heavy element detectors.

  20. TRYPTASE OF ORAL LIQUID AND IgE-ANTIBODIES AS A MARKER OF ALLERGIC INFLAMMATION IN THE ORAL MUCOSA

    Directory of Open Access Journals (Sweden)

    I. Yu. Karpuk

    2018-01-01

    Full Text Available The goal of present study was to determine the levels of mast cell tryptase (MCT in whole saliva, and blood serum IgE antibodies in patients with intolerance for dental prosthetic materials (IDM before and after removal of prosthetic constructs. We have conducted examination of the patients suffering from the IDM symptoms, who were divided into 2 groups depending on the time span between the end of prosthetic treatment and emergence of pathological symptoms: group 1 (n = 19, 1 to 14 days (symptoms emerged immediately after treatment; group 2, (n = 18, IDM symptoms occuring 6 months to 5 years later; group 3 (n = 16, controls without complaints for IDM. Whole saliva (WS samples were collected before removal of prosthetic constructs and 1 month later. In group 1, salivary MCT was detected in 16 subjects (84.2% before removal of prosthetic constructs, while 1 month after MCT not detectable in saliva (p < 0.001. Salivary MCT in control group was not detected both before and after removal of prosthetic constructions. Hence, mast cell tryptase in whole saliva could be a diagnostic marker for intolerance to dental materials. In group 1 of the patients, we detected IgE antibodies to Ni-HSA in 78.9% of patients, IgE antibodies to Cr-HSA in 68.4% of patients and IgE to Co-HSA in 52.6% of patients. Salivary MCT levels strongly correlated with IgE levels to Ni-HSA (Rspearman = 0.9; p < 0.05, showing moderate correlation with Cr-HSA (Rspearman = 0.7; p < 0.05. The data obtained suggest some prevalence of immediate type immune reaction against dental materials. Notable local increase of MCT level could be an important diagnostic marker of local inflammatory process initiation. MCT in whole saliva was found only in 3 patients (16.7% from group 2; those had IgE antibodies to metal ions in blood serum, thus indicating IgE-dependent reaction type. Other patients from group 2 were likely to develop a different type of allergic reaction, e. g. delayed or

  1. The Effect of Integration of Self-Management Web Platforms on Health Status in Chronic Obstructive Pulmonary Disease Management in Primary Care (e-Vita Study): Interrupted Time Series Design.

    Science.gov (United States)

    Talboom-Kamp, Esther Pwa; Verdijk, Noortje A; Kasteleyn, Marise J; Harmans, Lara M; Talboom, Irvin Jsh; Looijmans-van den Akker, Ingrid; van Geloven, Nan; Numans, Mattijs E; Chavannes, Niels H

    2017-08-16

    Worldwide nearly 3 million people die from chronic obstructive pulmonary disease (COPD) every year. Integrated disease management (IDM) improves quality of life for COPD patients and can reduce hospitalization. Self-management of COPD through eHealth is an effective method to improve IDM and clinical outcomes. The objective of this implementation study was to investigate the effect of 3 chronic obstructive pulmonary disease eHealth programs applied in primary care on health status. The e-Vita COPD study compares different levels of integration of Web-based self-management platforms in IDM in 3 primary care settings. Patient health status is examined using the Clinical COPD Questionnaire (CCQ). The parallel cohort design includes 3 levels of integration in IDM (groups 1, 2, 3) and randomization of 2 levels of personal assistance for patients (group A, high assistance, group B, low assistance). Interrupted time series (ITS) design was used to collect CCQ data at multiple time points before and after intervention, and multilevel linear regression modeling was used to analyze CCQ data. Of the 702 invited patients, 215 (30.6%) registered to a platform. Of these, 82 participated in group 1 (high integration IDM), 36 in group 1A (high assistance), and 46 in group 1B (low assistance); 96 participated in group 2 (medium integration IDM), 44 in group 2A (high assistance) and 52 in group 2B (low assistance); also, 37 participated in group 3 (no integration IDM). In the total group, no significant difference was found in change in CCQ trend (P=.334) before (-0.47% per month) and after the intervention (-0.084% per month). Also, no significant difference was found in CCQ changes before versus after the intervention between the groups with high versus low personal assistance. In all subgroups, there was no significant change in the CCQ trend before and after the intervention (group 1A, P=.237; 1B, P=.991; 2A, P=.120; 2B, P=.166; 3, P=.945). The e-Vita eHealth-supported COPD

  2. Toward a New, Musical Paradigm of Place: The Port River Symphonic of Chester Schultz

    Directory of Open Access Journals (Sweden)

    Robin, Ryan

    2014-05-01

    Full Text Available In privileging music as a focus for applied ecology, the goal of this essay is to deepen perspectives on the musical representation of land in an age of complex environmental challenge. As the metaphor driving public narration of environmental crises, the notion of Earth as our home—signified by the prefix “eco”—brings with it a critical expectation for the musical academy to retreat from bland talk about a “sense of place.” Based on the premise that damaged ecologies are a matter of concern to many people, Indigenous and Settler; and building on the late Val Plumwood’s theory of “shadow” or “denied” places (Australian Humanities Review 44, 2008, the author introduces Within Our Reach: A Symphony of the Port River Soundscapes by anti-elitist South Australian composer Chester Schultz (b. 1945. Inspired by the tradition of R. Murray Schafer’s performances for outdoor sites, Schultz predicated this niche symphony on the noise-polluting defoliation of Adelaide’s “wetland wonder,” the Old Port Reach. Presented as a series of narrative soundscapes, the symphony harnesses the power of music, including popular genres, to engender a sense of local “belonging” to the Port. In an ecological subtext an Indigenous Elder sings in the re-awakening language of the Kaurna people who, in 1890, were evicted from their “nourishing terrain” (terminology after Rose, 1996 by the CSR Sugar Refinery. Schultz’s ethical musical representation of local oral, natural and industrial history generates a benchmark opus for what shadow place composition might sound like in the modern global city.

  3. World Energy Scenarios 2050: Impact of the Energy Governance Models to the Future of the European Energy Sector

    International Nuclear Information System (INIS)

    Kisel, E.

    2014-01-01

    World Energy Council has explored the impact of two extreme governance models of energy sector to the global economic and climate developments. Scenario 'Jazz' describes the world, where investments in the energy markets are made by the companies on the purely economic basis. Scenario 'Symphony' describes the world, where decisions about the energy investments are made by the governments. It appears that in case of Scenario 'Jazz' we would reach lower energy prices, but it would also bring along higher and wider consumption of energy, and much higher environmental impact. In case of Scenario 'Symphony' energy prices would be somewhat higher, but environmental and energy efficiency would deliver better results, and there will be more energy-poor people around the world. It can also be observed, that resulting energy mixes of these two scenarios are very different. When Scenario 'Jazz' would leave the share of fossil fuels nearly to the current levels, then Scenario 'Symphony' supports strongly development of Solar and Carbon Capture, Utilisation and Sequestration Technologies. The modelling was also made separately for different regions of the world, the results for Europe can be observed from the report as well. This provides a fruit for thought about the role of the governments in the implementation of the EU 2030 Energy and Climate Strategy. The presentation would describe shortly the methodology of the study, clarifies the assumptions of the scenarios and highlights the main outcomes of the study in for the world and for European energy sector. (author).

  4. Effective doses from panoramic radiography and CBCT (cone beam CT) using dose area product (DAP) in dentistry.

    Science.gov (United States)

    Shin, H S; Nam, K C; Park, H; Choi, H U; Kim, H Y; Park, C S

    2014-01-01

    We compared the effective dose from panoramic radiography with that from cone beam CT (CBCT) using dose area product under adult and child exposure conditions. The effective doses of the cephalo, panorama, implant and dental modes of Alphard 3030 (Asahi Roentgen Ind., Co. Ltd, Kyoto, Japan) CBCT and the Jaw, Wide, Facial and temporomandibular joint modes of Rayscan Symphony (RAY Co., Ltd, Hwaseong, Republic of Korea) CBCT were compared with those of CRANEX(®) 3+ CEPH (Soredex Orion Corporation, Helsinki, Finland) panoramic radiography equipment under adult and child exposure conditions. Each effective dose was calculated using a conversion formula from dose area product meter measured values (VacuTec Messtechnik GmbH, Dresden, Germany). The conversion formulae used were suggested by Helmrot and Alm Carlsson and Batista et al, and they were applied with the tube voltage taken into consideration. The maximum effective doses from the Alphard 3030 and Rayscan Symphony were 67 and 21 times greater than that from panoramic radiography, respectively. The ratios of the effective dose under the child setting to that under the adult condition were 0.60-0.62 and 0.84-0.95, and the maximum differences in effective doses between the adult and child exposure settings were equivalent to 27 and 4 times greater than a panoramic examination in the Alphard 3030 and Rayscan Symphony, respectively. The effective CBCT doses were higher than those of panoramic radiography. The differences in effective doses between the adult and child CBCT settings were dependent on equipment type and exposure parameters. Therefore, adequate mode selection and control of exposure as well as further research are necessary to minimize the effective dose to patients, especially for radiosensitive children.

  5. Carl Nielsen's voice

    DEFF Research Database (Denmark)

    Reynolds, Anne-Marie

    works, the first symphony and the opera Masquerade. This is done with a view to demonstrating that the opposition between Carl Nielsen as a composer of songs and Carl Nielsen as the composer of "great" works is only a seeming opposition. The book which is the result a collaboration with Niels Krabbe......, head of the Carl Nielsen Edition at The Royal Library will be published simultaneously with the publication of approximately 300 of the composer's songs, the last volume in the collected edition of Carl Nielsen's works....

  6. BALTICA IV. Plant maintenance for managing life and performance

    Energy Technology Data Exchange (ETDEWEB)

    Hietanen, S.; Auerkari, P. [eds.] [VTT Manufacturing Technology, Espoo (Finland). Operational Reliability

    1998-12-31

    BALTICA IV International Conference on Plant Maintenance Managing Life and performance held on September 7-9, 1998 on board M/S Silja Symphony on its cruise between Helsinki-Stockholm and at Aavaranta in Kirkkonummi. The BALTICA IV conference provides a forum for the transfer of technology from applied research to practice. This is one of the two volumes of the proceedings of the BALTICA IV International Conference on Plant Maintenance Managing Life and Performance. The BALTICA IV conference focuses on new technology, recent experience and applications of condition and life management, and on improvements in maintenance strategies for safe and economical operation of power plants. (orig.)

  7. Digital Networked Information Society and Public Health: Problems and Promises of Networked Health Communication of Lay Publics.

    Science.gov (United States)

    Kim, Jeong-Nam

    2018-01-01

    This special issue of Health Communication compiles 10 articles to laud the promise and yet confront the problems in the digital networked information society related to public health. We present this anthology of symphony and cacophony of lay individuals' communicative actions in a digital networked information society. The collection of problems and promise of the new digital world may be a cornerstone joining two worlds-pre- and postdigital network society-and we hope this special issue will help better shape our future states of public health.

  8. West Europe Report.

    Science.gov (United States)

    1985-06-19

    then with Klaus Kinkel on the planning staff, with Guenter van Well as the "first" state secretary, with Berndt von Staden as the departmental head...Berlin Philharmonic, "I will do this next Beethoven symphony on my own." "I like this man," were also Helmut Schmidt’s words of praise following his...first came close to reaching the 50 percent mark and Ludwig Erhard was toppled as chancellor soon thereafter, or the Land parliamentary elections of

  9. Physics for Mathematicians

    Science.gov (United States)

    Ulam, S. M.

    2014-11-01

    When I was asked to give a talk here, being just a mathematician among the distinguished array of physicists invited to speak, I had great hesitation. Then it occurred to me, if Viki Weisskopf can conduct a symphony orchestra, maybe I can talk about physics. I felt consoled until yesterday evening when I discovered that he is a professional, and so I feel very, hesitant again. My title, "Physics for Mathematicians", will almost mean physics without mathematics. My interest is really to paraphrase a famous statement, not what mathematics can do for physics, but what physics can do for mathematics. That is the underlying motive...

  10. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Firmament des toiles Joëlle Lalagüe Du 6 au 16 juin 2017 CERN Meyrin, Bâtiment principal Phylaë Voyage - Joëlle Lalagüe. Each picture is an invitation for a cosmic trip. This is a whispering of soul, which comes from origins. A symphony of the world, some notes of love, a harmony for us to fly to infinity. Pour plus d’informations et demandes d'accès : staff.association@cern.ch | Tél: 022 766 37 38

  11. Cosmos in Concert: Combining astronomy and classical music

    Science.gov (United States)

    Kremer, Kyle

    2018-01-01

    Cosmos in Concert is an outreach initiative designed to combine astronomy education with classical music. Over the past several years, this program has presented large-scale multimedia shows for symphony orchestras, educational programs at K-12 schools, and research-oriented university collaborations designed to develop techniques for the sonification of data. Cosmos in Concert has collaborated with institutions including Fermi National Lab, the Adler Planetarium, the Bienen School of Music, and the Colburn School of Music. In this talk, I will give a brief overview of some of the main Cosmos in Concert initiatives and discuss ways these initiatives may be implemented at other institutions.

  12. Histories of Leadership in the Copenhagen Phil

    DEFF Research Database (Denmark)

    Møller, Søren Friis

    2017-01-01

    The article offers a cultural view of narrativity in studies of leadership in addition to the mimetic, the structural and the communicative views to account for the role of culture in making sense of leadership. It proposes three interlinked aspects of narrativity: performativity, structure...... and cultural embeddedness as methodological considerations challenging the alleged innocence of narratives. It demonstrates the cultural propensity of certain understandings of leadership, and it suggests historical accounts of leadership constitute templates for future understandings of leadership....... This is unfolded in the case of a symphony orchestra, and exemplified by two narratives producing different understandings of leadership....

  13. Recent multi-purpose hall designs in Denmark with physically variable acoustics

    DEFF Research Database (Denmark)

    Gade, Anders Christian

    1999-01-01

    house. This hall is used for symphonic concerts and musicals as well as drama and conferences. In this hall, maintaining or even increasing G along with a reduction in T is advantageous, especially in the drama theatre mode. The paper will describe the design of these two halls along with acoustic...... and be used for chamber music concerts, symphony orchestra rehearsals, and amplified speech. For the latter two functions, a reduction in G along with reduction in T was considered favorable. The hall with variable volume is the recently opened Esbjerg Musikhus seating 1100 and equipped with a full stage...

  14. Occurrence of non-steroidal anti-inflammatory drugs in Tehran source water, municipal and hospital wastewaters, and their ecotoxicological risk assessment.

    Science.gov (United States)

    Eslami, Akbar; Amini, Mostafa M; Yazdanbakhsh, Ahmad Reza; Rastkari, Noushin; Mohseni-Bandpei, Anoushiravan; Nasseri, Simin; Piroti, Ehsan; Asadi, Anvar

    2015-12-01

    Pharmaceuticals are becoming widely distributed in waters and wastewaters and pose a serious threat to public health. The present study aimed to analyze non-steroidal anti-inflammatory drugs (NSAIDs) in surface waters, drinking water, and wastewater in Tehran, Iran. Thirty-six samples were collected from surface waters, tap water, and influent and effluent of municipal and hospital wastewater treatment plants (WWTP). A solid-phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry method was used for the determination of pharmaceuticals, namely ibuprofen (IBP), naproxen (NPX), diclofenac (DIC), and indomethacin (IDM). IBP was found in most of the samples and had the highest concentration. The highest concentrations of NSAIDs were found in the municipal WWTP influents and hospital WWTP effluents. In the municipal WWTP influent samples, the concentrations of IBP, NPX, DIC, and IDM were 1.05, 0.43, 0.23, and 0.11 μg/L, respectively. DIC was found only in one river sample. All NSAIDs were detected in tap water samples. However, their concentration was very low and the maximum values for IBP, NPX, DIC, and IDM were 47, 39, 24, and 37 ng/L, respectively, in tap water samples. Results showed that the measured pharmaceuticals were detected in all rivers with low concentrations in nanograms per liter range, except DIC which was found only in one river. Furthermore, this study showed that the aforementioned pharmaceuticals are not completely removed during their passage through WWTPs. A potential environmental risk of selected NSAIDs for the urban wastewater has been discussed. However, given their low measured concentrations, no ecotoxicological effect is suspected to occur.

  15. Contents of selected B vitamins in NIST SRM 3280 multivitamin/multielement tablets by liquid chromatography isotope dilution mass spectrometry.

    Science.gov (United States)

    Chen, Pei; Ozcan, Mustafa; Wolf, Wayne R

    2007-09-01

    There is increased interest in accurately assessing the total dietary intake of vitamins from all sources, including foods and dietary supplements. Consequently, a Dietary Supplement Ingredient Database (DSID), based upon analytical values, is being established by USDA with support of the Office of Dietary Supplements (ODS), NIH. The DSID necessitated the development of a new SRM, 3280--Multivitamin/Multimineral Tablets, by the National Institute of Standards and Technology (NIST), with support from the ODS. As a continuation of a long-term project to develop and validate new methods of determining water-soluble B vitamins in foods and dietary supplements, and as part of a collaborative effort with NIST to characterize SRM 3280, values for the vitamin contents of SRM 3280 have been generated by a liquid chromatographic isotope dilution mass spectrometric (LC/IDMS) method. Isotope-labeled ((13)C and/or (2)H) B vitamins (B1-thiamine, B6-pyridoxine, B3-nicotinamide, and B5-pantothenic acid) were obtained from commercial sources, with the support of the ODS/NIH. Our LC/IDMS method uses a C18 reversed phase column, an Agilent 1100 HPLC system, and a Quattro Micro triple-quad mass spectrometer (MS). B vitamin determination was achieved using a gradient LC profile combined with MS/MS detection in multiple reaction monitoring mode. Stock solutions of the isotope-labeled vitamins were calibrated against USP standard solutions. The SRM tablets, with added amounts of the four isotope-labeled B vitamins, were extracted and the vitamins simultaneously determined in a single LC run, in contrast with the single-component determinations performed via IDMS. Unknown vitamin concentrations were calculated by comparing the ratios of the integrated LC peaks at the different masses of the unlabeled and labeled vitamins.

  16. Concerted Efforts to Control or Eliminate Neglected Tropical Diseases: How Much Health Will Be Gained?

    Directory of Open Access Journals (Sweden)

    Sake J de Vlas

    2016-02-01

    Full Text Available The London Declaration (2012 was formulated to support and focus the control and elimination of ten neglected tropical diseases (NTDs, with targets for 2020 as formulated by the WHO Roadmap. Five NTDs (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths and trachoma are to be controlled by preventive chemotherapy (PCT, and four (Chagas' disease, human African trypanosomiasis, leprosy and visceral leishmaniasis by innovative and intensified disease management (IDM. Guinea worm, virtually eradicated, is not considered here. We aim to estimate the global health impact of meeting these targets in terms of averted morbidity, mortality, and disability adjusted life years (DALYs.The Global Burden of Disease (GBD 2010 study provides prevalence and burden estimates for all nine NTDs in 1990 and 2010, by country, age and sex, which were taken as the basis for our calculations. Estimates for other years were obtained by interpolating between 1990 (or the start-year of large-scale control efforts and 2010, and further extrapolating until 2030, such that the 2020 targets were met. The NTD disease manifestations considered in the GBD study were analyzed as either reversible or irreversible. Health impacts were assessed by comparing the results of achieving the targets with the counterfactual, construed as the health burden had the 1990 (or 2010 if higher situation continued unabated.Our calculations show that meeting the targets will lead to about 600 million averted DALYs in the period 2011-2030, nearly equally distributed between PCT and IDM-NTDs, with the health gain amongst PCT-NTDs mostly (96% due to averted disability and amongst IDM-NTDs largely (95% from averted mortality. These health gains include about 150 million averted irreversible disease manifestations (e.g. blindness and 5 million averted deaths. Control of soil-transmitted helminths accounts for one third of all averted DALYs. We conclude that the projected

  17. Improved laboratory assays of Pu and U for SRP purification and finishing processes

    International Nuclear Information System (INIS)

    Holland, M.K.; Dorsett, R.S.

    1986-01-01

    Significant improvements have been made in routine assay techniques for uranium and plutonium as part of an effort to improve accountability at the Savannah River Plant (SRP). Emphasis was placed on input/output accountability points and key physical inventory tanks associated with purification and finishing processes. Improvements were made in existing assay methods; new methods were implemented; and the application of these methods was greatly expanded. Prior to assays, samples were validated via density measurements. Digital density meters precise to four, five, and six decimal places were used to meet specific requirements. Improved plutonium assay techniques are now in routine use: controlled-potential coulometry, ion-exchange coulometry, and Pu(III) diode-array spectrophotometry. A new state-of-the-art coulometer was fabricated and used to ensure maximum accuracy in verifying standards and in measuring plutonium in product streams. The diode-array spectrophotometer for Pu(III) measurements was modified with fiber optics to facilitate remote measurements; rapid, precise measurements made the technique ideally suited for high-throughput assays. For uranium assays, the isotope-dilution mass spectrometric (IDMS) method was converted to a gravimetric basis. The IDMS method and the existing Davies-Gray titration (gravimetric basis) have met accountability requirements for uranium. More recently, a Pu(VI) diode-array spectrophotometric method was used on a test basis to measure plutonium in shielded-cell input accountability samples. In addition, tests to measure uranium via diode-array spectrophotometry were initiated. This rapid, precise method will replace IDMS for certain key sample points

  18. Protective effect of Holothurian intestine against indomethacin induced gastric mucosal damage in rats

    Science.gov (United States)

    Li, Xiaoyu; Qiao, Xuejing; Zhang, Cuiping; Gao, Hua; Niu, Qinghui; Wu, Tong; Zhang, Qi; Tian, Zibin

    2017-06-01

    Our study aimed to investigate the protective effects of Holothurian intestines (HI) on NSAIDs-induced gastric mucosal damage and the possible mechanism. At first, 60 male Wistar rats were induced of gastric lesions with indomethacin (IDM, 30 mg kg-1). The rats were pretreated for 15 consecutive days with saline, sucralfate, or HI (0.4 g kg-1d-1, 0.8 g kg-1d-1 and 1.6 g kg-1d-1) prior to IDM treatment, followed by evaluations of macroscopic damage and microscopic features; and investigation of the levels of inflammatory cytokines, oxidative stress parameters, gastric mucosal prostaglandin E2 (PGE2) and total hexosamine in tissues. The expression of COX-1 and COX-2 mRNA in the gastric tissue were determined by quantitative polymerase chain reaction (qPCR). Pathological gastric ulcer indexes, levels of pro-inflammatory cytokines (IL-1β, IL-17, TNF-α) and lipid peroxidation were significantly decreased in HI-treated groups, whereas the levels of protective factors (TGF-β, GSH, SOD activity and PGE2) were significantly elevated especially in the group with HI 1.6 g kg-1d-1 ( P < 0.05). Furthermore, the expression of COX-2 mRNA decreased significantly in HI groups ( P < 0.05). The study investigates that holothurian intestines may act as a kind of marine medicine which have protective effect on IDM-induced gastric ulcer, which could be a dietary preventive agent for the prevention of gastric damage.

  19. Non HLA genetic markers association with type 1-diabetes mellitus

    African Journals Online (AJOL)

    Soheir S. Abou El-Ella

    diabetic 44 sibs, aged 3–15 years and their parents were included in our study. All studied ... the presence of permissive environment [1]. At present, more ..... Low birth weight. 22.2. 2. 12.5. 1. 33.3. 3. IDM. 11.1. 1. 22.2. 2. 11.1. 1. Family history +ve. 66.7. 6. 88.8. 8. 33.3. 3. 9.81. >0.05. Other sibling affection +ve. 0. 0. 22.2. 2.

  20. Secure bindings of SAML assertions to TLS sessions

    DEFF Research Database (Denmark)

    Kohlar, Florian; Schwenk, Jörg; Jensen, Meiko

    2010-01-01

    In recent research work, two approaches to protect SAML based Federated Identity Management (FIM) against man-in-the-middle attacks have been proposed. One approach is to bind the SAML assertion and the SAML artifact to the public key contained in a TLS client certificate. Another approach...... is to strengthen the Same Origin Policy of the browser by taking into account the security guarantees TLS gives. In this paper, we present a third approach which is of further interest beyond IDM protocols: we bind the SAML assertion to the TLS session that has been agreed upon between client and the service...

  1. Release of ammonia from HAN-type PHA

    International Nuclear Information System (INIS)

    Zamecnik, J.R.

    1992-01-01

    A preliminary design basis for ammonia scrubbers in the DWPF has been issued. This design basis is based on a theoretical model of ammonia evolution from the SRAT, SME and RCT. It is desirable to acquire actual process data on ammonia evolution prior to performing detailed design of scrubbers for DWPF. The evolution of ammonia from the SRAT and SME in the Integrated DWPF Melter System (IDMS) was investigated during the HM4 run. In this run, Precipitate Hydrolysis Aqueous (PHA), which was made in the Precipitate Hydrolysis Experimental Facility (PHEF) using the HAN (hydroxylamine nitrate) process was used, thus resulting in PHA with a high concentration of ammonium ion

  2. A framework for implementation of user-centric identity management systems

    DEFF Research Database (Denmark)

    Adjei, Joseph K.; Olesen, Henning

    2010-01-01

    Users increasingly become part of electronic transactions, which take place instantaneously without direct user involvement. This leads to the risk of data manipulation, identity theft and privacy violation, and it has become a major concern for individuals and businesses around the world. Gov-ernments...... in many countries are implementing identity man-agement systems (IdMS) to curtail these incidences and to offer citizens the power to exercise informational self-determination. Using concepts from technology adoption and fit-viability theo-ries as well as the laws of identity, this paper analyzes...

  3. Extending the diffusion approximation to the boundary using an integrated diffusion model

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen; Du, Zhidong; Pan, Liang, E-mail: liangpan@purdue.edu [School of Mechanical Engineering, Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907 (United States)

    2015-06-15

    The widely used diffusion approximation is inaccurate to describe the transport behaviors near surfaces and interfaces. To solve such stochastic processes, an integro-differential equation, such as the Boltzmann transport equation (BTE), is typically required. In this work, we show that it is possible to keep the simplicity of the diffusion approximation by introducing a nonlocal source term and a spatially varying diffusion coefficient. We apply the proposed integrated diffusion model (IDM) to a benchmark problem of heat conduction across a thin film to demonstrate its feasibility. We also validate the model when boundary reflections and uniform internal heat generation are present.

  4. Applying strategies from libertarian paternalism to decision making for prostate specific antigen (PSA screening

    Directory of Open Access Journals (Sweden)

    Black Amanda

    2011-04-01

    Full Text Available Abstract Background Despite the recent publication of results from two randomized clinical trials, prostate specific antigen (PSA screening for prostate cancer remains a controversial issue. There is lack of agreement across studies that PSA screening significantly reduces prostate cancer mortality. In spite of these facts, the widespread use of PSA testing in the United States leads to overdetection and overtreatment of clinically indolent prostate cancer, and its associated harms of incontinence and impotence. Discussion Given the inconclusive results from clinical trials and incongruent PSA screening guidelines, the decision to screen for prostate cancer with PSA testing is an uncertain one for patients and health care providers. Screening guidelines from some health organizations recommend an informed decision making (IDM or shared decision making (SDM approach for deciding on PSA screening. These approaches aim to empower patients to choose among the available options by making them active participants in the decision making process. By increasing involvement of patients in the clinical decision-making process, IDM/SDM places more of the responsibility for a complex decision on the patient. Research suggests, however, that patients are not well-informed of the harms and benefits associated with prostate cancer screening and are also subject to an assortment of biases, emotion, fears, and irrational thought that interferes with making an informed decision. In response, the IDM/SDM approaches can be augmented with strategies from the philosophy of libertarian paternalism (LP to improve decision making. LP uses the insights of behavioural economics to help people better make better choices. Some of the main strategies of LP applicable to PSA decision making are a default decision rule, framing of decision aids, and timing of the decision. In this paper, we propose that applying strategies from libertarian paternalism can help with PSA

  5. Extending the diffusion approximation to the boundary using an integrated diffusion model

    Directory of Open Access Journals (Sweden)

    Chen Chen

    2015-06-01

    Full Text Available The widely used diffusion approximation is inaccurate to describe the transport behaviors near surfaces and interfaces. To solve such stochastic processes, an integro-differential equation, such as the Boltzmann transport equation (BTE, is typically required. In this work, we show that it is possible to keep the simplicity of the diffusion approximation by introducing a nonlocal source term and a spatially varying diffusion coefficient. We apply the proposed integrated diffusion model (IDM to a benchmark problem of heat conduction across a thin film to demonstrate its feasibility. We also validate the model when boundary reflections and uniform internal heat generation are present.

  6. Application of Imprecise Decision Modeling for Regional Development Policies in Indonesia

    Directory of Open Access Journals (Sweden)

    Novita Erlinda

    2016-06-01

    Full Text Available Regional Development encompasses many aspect of economic, social, and environmental attributes. In the context of developing country, the decision to fulfill these attributes are often hindered by lack of clear development scenarios and constraints. This study is an attempt to capture the complexity of decision makers for regional development scenarios using imprecise decision modeling (IDM by incorporating imprecise information and uncertainties. A series of social, economic and environmental criteria based on agreement from multi stakeholders dialogues were developed along with four policy development scenarios. Results from such a modeling provides variety of decision alternatives based on probabilities and risk assessment associated with achieving policy objectives.

  7. Photodynamic therapy with photofrin II derivative in the treatment of carcinosarcoma of rats with diabetes mellitus

    Science.gov (United States)

    Dima, Vasile F.; Vasiliu, Virgil V.; Ionescu, Mircea D.; Laky, Dezideriu

    1995-03-01

    Four batches of Wistar rats with Walker-256 carcinosarcoma were used to test the effects of PDT upon `in vivo' tumor growth. Ten days after tumor transplantation, rats from batch I(DM) were exposed to Photofrin II (20 mg/kg), given i.p. 24 h before exposure to laser (632.8 nm; 10 mw; He-Ne laser), five doses given at 4 days intervals; batch II and batch III received sole treatment (DM or PDT). The control batch IV included animals with untreated Walker-256 tumors. The animals were followed up 42 days.

  8. US Army Institute of Surgical Research Annual Research Progress Report, FY 1980.

    Science.gov (United States)

    1980-10-01

    INVESTIGATOR$ MAmE, FOREIGN INTELLIGENCE NOT CONSIDERED N DE DA .X EEBR cm. Afl AS& JNIY CI.IDM.Vd’ C*f) (U) Humans; (U) Dogs ; (U) Resuscitation Fluids; (U...Casaburi, Ret all: Hypopnea Consequent to Reduced Pulmonary Blood Flow in the Dog . J. Applied Physiology, 46: 1171-1177, 1979. 5. Wasserman, K, Whipp, BJ...G. Owen OE: Hepatic ketogenesis and gluconeogenesis in humans. J Clin Invest 54:981-989, 1974. 210 ,’In a. "~ . - " . . . . . .. ’-’ .... , In

  9. Using BCF as a mediator for task management in building design

    DEFF Research Database (Denmark)

    Treldal, Niels; Parsianfar, Hussain; Karlshøj, Jan

    2016-01-01

    buildingSMART has adopted the BIM Collaboration Format (BCF) to improve interoperability in the field of process information exchange. The original scope of BCF was linked to a need to communicate BIM-related tasks, but a further expansion of the BCF format should be considered to add additional...... on these findings, we propose an information system consisting of decentralised model and task servers using both BCF and IFC. Using IDM Part 2 as an example, we further propose an architecture to expand BCF....

  10. Prevalence of orthorexia nervosa among Turkish performance artists.

    Science.gov (United States)

    Aksoydan, E; Camci, N

    2009-03-01

    The aim of the study was to determine the prevalence of orthorexia nervosa among the performance artists in the State Opera and Ballet and in the Bilkent University Symphony Orchestra. The study population consisted of 39 men and 55 women for a total of 94 artists with mean age of 33 years. The ORTO-15 test was used to determine the prevalence of orthorexia nervosa. Those subjects who scored below 40 in the ORTO-15 test were classified as having orthorexia nervosa. Mean score of the participants in the ORTO-15 test was 37.9+/-4.46. A total of 56.4% of the artists involved in the research scored below 40 in the ORTO-15 test. While the highest prevalence of orthorexia nervosa was recorded among opera singers (81.8%), it was 32.1% among ballet dancers and 36.4% among symphony orchestra musicians. The differences between the three groups were statistically significant. No difference was noted between mean ORTO-15 score by baseline characteristics as gender, age, educational level, work experience, body mass index, smoking and alcohol consumption. The research group have a higher socio-economic and education level than the majority of the general public in Turkey. Additionally, being an artist in Turkey means being a role model for the general public both in terms one's physical appearance and lifestyle. These may be the reason why artists are more sensitive to this issue.

  11. Petar Bergamo’s symphonic compositions: Perspectives of the 1960s and 1990s

    Directory of Open Access Journals (Sweden)

    Simonović-Schiff Jelena Đ.

    2004-01-01

    Full Text Available This article deals with the orchestral opus of Petar Bergamo, a Croat composer whose most productive period was linked to Beograd, Serbia where he lived and worked at the time. In four works: First Symphony overture-phantasy Navigare necesse est, Musica Concertante and Second Symphony, all conceived in just four consecutive years (1960 - 1963, the matter being treated through author’s technical tools includes authentic materials, autoquotations, quasiquotations, quotations, and the ‘fund’ mode (fundus. Fragments of musical history embedded in the newly established structure, void of tonal components and orchestrated in great detail to achieve the coloration which may prevail the actual form, introduced to Serbian practice a new respect for the old. Since it was new, Bergamo’s contribution could not have been determined at that time in all of its significance. Laying his agenda on the dead-end street of what was considered modern art, Bergamo earned an attribute of post, regarding his respect for the past. The reception of Bergamo’s opus is viewed here through various articles and critiques from the time of its inception as well as thirty years later. From the viewpoint of the 1990s it appears that his language or at least some of its elements had become the impetus for one particular stream of local compositional teaching. As such, this strengthens his position as a fundamental innovator, and labels him as the one who imposed the post in modern Serbian music.

  12. 7. Advocating the Poetics of Sound in the Cycle Les Nuits d´Été by Hector Berlioz

    Directory of Open Access Journals (Sweden)

    Iațeșen Loredana Viorica

    2018-03-01

    Full Text Available By consulting monographies, musicological studies, specialty articles about the personality of romantic musician Hector Berlioz and implicitly linked to the relevance of his significant opera, one discovers researchers’ constant preoccupation for historical, stylistic, analytical, hermeneutical comments upon aspects related to established scores (the Fantastic, Harold in Italy symphonies, dramatic legend The Damnation of Faust, dramatic symphony Romeo and Juliet, the Requiem, etc.. Out of his compositions, it is remarkable that the cycle Les nuits d´été was rarely approached from a musicological point of view, despite the fact that it is an important opus, which inaugurates the genre of the orchestral lied at the end of the 19th century and the beginning of last century. In this study, we set out to compose as complete as possible an image of this work, both from an analytic-stylistic point of view by stressing the text-sound correspondences and, above all, from the perspective of its reception at a didactic level, by promoting the score in the framework of listening sessions commented upon as part of the discipline of the history of music. In what follows, I shall argue that the cycle of orchestral lieder Les nuits d´été by Hector Berlioz represents a work of equal importance to established opera.

  13. Altered but Not Silenced: How Shostakovich Retained His Voice as an Artist despite the Demands of a Dictator

    Directory of Open Access Journals (Sweden)

    Hope R. Strayer

    2013-12-01

    Full Text Available Can music that is regulated and restrained by a dictator still be inspired? This question reveals ideology concerning how music should be created and valued. Does outside control restrict artistic integrity and autonomy? Not all composers have been free to write whatever their soul demands. People in authority have held power and control over artistic processes. Dmitri Shostakovich was a Russian composer whose work was subjected to the tastes of a tyrannical ruler and Communist party. Though Shostakovich did not compose in an environment that fostered musical exploration, his work should not be mourned but celebrated. Shostakovich was not a victim, but a victor of his music by the way he composed in the midst of the threat of denouncement. Though Shostakovich wrote music to follow the demands of others, the music was still his by the very fact that he created it; he brought it into existence and highlighted it with nuances of his being and personality as he produced each work. This research examines three critical pieces of Shostakovich’s canon to ascertain whether controlled art subjected to the whims, preferences, and objectives of others can still be inspired. Though a composer might be told what to say, it is he who chooses how to word a phrase. Shostakovich’s output, particularly the first symphony, his opera Lady Macbeth of the Mtsensk District, and fifth symphony exemplify that restrained and restricted music does not necessitate a sacrifice in artistic integrity; it can be inspired, celebrated, and worthy of study.

  14. Andrej Belyj. Sinfonia (2-a, la drammatica. E il tempo scorreva senza sosta…

    Directory of Open Access Journals (Sweden)

    Giuseppina Giuliano

    2016-05-01

    Full Text Available Andrej Belyj (1913-1914, esordisce nel 1902 con un’opera che inaugura in Russia il genere letterario della sinfonia. Nell’introduzione a Sinfonia (2-a, la drammatica Belyj spiega che l’opera «ha tre significati: uno musicale, uno satirico e uno ideologico-simbolico».  Dal «significato musicale», che porta l’autore a «dividere la sinfonia in parti, le parti in frammenti e i frammenti in versi (frasi musicali», nasce il genere misto di prosa e poesia di cui Belyj si serve per enfatizzare il contenuto mistico, satirico e grottesco dell’opera, che caratterizzerà poi anche Pietroburgo. Nella Seconda sinfonia}Belyj prende di mira i gruppi di mistici che andavano formandosi all’inizio del Novecento a Mosca e Pietroburgo, citando esplicitamente o raffigurando velatamente personaggi reali del mondo della letteratura, dell’arte e della filosofia, come Vladimir Solov’ev (1853-1900, Dmitrij Merežkovskij (1865-1941 e altri.  Motivi strettamente autobiografici vengono così presentati sotto forma di immagini grottesche e iperboliche, alternate a momenti di estremo lirismo. Al «significato musicale» è legata anche la particolare scansione del tempo in cui si dispiega la trama dell’opera, che inizia con il lento trascorrere di un’intera giornata e accelera poi nel passare dei mesi e delle stagioni per ritornare, ciclicamente e drammaticamente, al punto di partenza. Questo procedimento artistico è ben sintetizzato in uno dei leitmotive dell’opera: «E il tempo scorreva senza sosta, e nello scorrere del tempo si rifletteva l’Eternità brumosa». Andrei Bely (1880-1934, poet, novelist, theorist and literary critic of the Russian Symbolist movement, author of the famous novel in rhythmic prose Petersburg (1913-1914, made his literary debut in 1902 with a work introducing in Russia a new literary genre, the symphony. In the introduction to The Dramatic Symphony, Bely explains that the work «has three meanings: a musical

  15. High Level of Integration in Integrated Disease Management Leads to Higher Usage in the e-Vita Study: Self-Management of Chronic Obstructive Pulmonary Disease With Web-Based Platforms in a Parallel Cohort Design.

    Science.gov (United States)

    Talboom-Kamp, Esther Pwa; Verdijk, Noortje A; Kasteleyn, Marise J; Harmans, Lara M; Talboom, Irvin Jsh; Numans, Mattijs E; Chavannes, Niels H

    2017-05-31

    Worldwide, nearly 3 million people die of chronic obstructive pulmonary disease (COPD) every year. Integrated disease management (IDM) improves disease-specific quality of life and exercise capacity for people with COPD, but can also reduce hospital admissions and hospital days. Self-management of COPD through eHealth interventions has shown to be an effective method to improve the quality and efficiency of IDM in several settings, but it remains unknown which factors influence usage of eHealth and change in behavior of patients. Our study, e-Vita COPD, compares different levels of integration of Web-based self-management platforms in IDM in three primary care settings. The main aim of this study is to analyze the factors that successfully promote the use of a self-management platform for COPD patients. The e-Vita COPD study compares three different approaches to incorporating eHealth via Web-based self-management platforms into IDM of COPD using a parallel cohort design. Three groups integrated the platforms to different levels. In groups 1 (high integration) and 2 (medium integration), randomization was performed to two levels of personal assistance for patients (high and low assistance); in group 3 there was no integration into disease management (none integration). Every visit to the e-Vita and Zorgdraad COPD Web platforms was tracked objectively by collecting log data (sessions and services). At the first log-in, patients completed a baseline questionnaire. Baseline characteristics were automatically extracted from the log files including age, gender, education level, scores on the Clinical COPD Questionnaire (CCQ), dyspnea scale (MRC), and quality of life questionnaire (EQ5D). To predict the use of the platforms, multiple linear regression analyses for the different independent variables were performed: integration in IDM (high, medium, none), personal assistance for the participants (high vs low), educational level, and self-efficacy level (General Self

  16. Investigation of mercury-containing proteins by enriched stable isotopic tracer and size-exclusion chromatography hyphenated to inductively coupled plasma-isotope dilution mass spectrometry

    International Nuclear Information System (INIS)

    Shi Junwen; Feng Weiyue; Wang Meng; Zhang Fang; Li Bai; Wang Bing; Zhu Motao; Chai Zhifang

    2007-01-01

    In order to investigate trace mercury-containing proteins in maternal rat and their offspring, a method of enriched stable isotopic tracer ( 196 Hg and 198 Hg) combined with size-exclusion chromatography (SEC) coupled to inductively coupled plasma-isotope dilution mass spectrometry (ICP-IDMS) was developed. Prior to the analysis, 196 Hg- and 198 Hg-enriched methylmercury was administrated to the pregnant rats. Then the mercury-containing proteins in serum and brain cytosol of the dam and pup rats were separated by size-exclusion columns and the mercury was detected by ICP-MS. The ICP-MS spectrogram of the tracing samples showed significantly elevated 196 Hg and 198 Hg isotopic signals compared with the natural ones, indicating that the detection sensitivity could be increased by the tracer method. The contents of mercury in chromatographic fractions of the dam and pup rat brain cytosol were quantitatively estimated by post-column reverse ID-ICP-MS. The quantitative speciation differences of mercury in brain cytosol between the dam and pup rats were observed, indicating that such studies could be useful for toxicological estimation. Additionally, the isotopic ratio measurement of 198 Hg/ 202 Hg in the tracing samples could be used to identify the artifact mercury species caused in the analytical procedure. The study demonstrates that the tracer method combined with high-performance liquid chromatography (HPLC)-ICP-IDMS could provide reliably qualitative and quantitative information on mercury-containing proteins in organisms

  17. Low energy gamma ray excess confronting a singlet scalar extended inert doublet dark matter model

    Directory of Open Access Journals (Sweden)

    Amit Dutta Banik

    2015-04-01

    Full Text Available Recent study of gamma rays originating from the region of galactic centre has confirmed an anomalous γ-ray excess within the energy range 1–3 GeV. This can be explained as the consequence of pair annihilation of a 31–40 GeV dark matter into bb¯ with thermal annihilation cross-section σv∼1.4–2.0×10−26 cm3/s. In this work we revisit the Inert Doublet Model (IDM in order to explain this gamma ray excess. Taking the lightest inert particle (LIP as a stable DM candidate we show that a 31–40 GeV dark matter derived from IDM will fail to satisfy experimental limits on dark matter direct detection cross-section obtained from ongoing direct detection experiments and is also inconsistent with LHC findings. We show that a singlet extended inert doublet model can easily explain the reported γ-ray excess which is as well in agreement with Higgs search results at LHC and other observed results like DM relic density and direct detection constraints.

  18. ENSURING OF RADIATION PROTECTION DURING WORKS ON TRANSFORMATION OF THE OBJECT SHELTER INTO ECOLOGICALLY SAFE SYSTEM. BIOPHYSICAL MONITORING OF THE PERSONNEL INTERNAL EXPOSURE DOSES

    Directory of Open Access Journals (Sweden)

    S. Yu. Nechaev

    2009-01-01

    Full Text Available Given paper, states the ensuring of the interpretation of the basic radiation protection principles, relative to the works at the Object Shelter (OS. Analysis of the factors of radiation situation at the OS is figured out. Functioning at the present time individual dose monitoring (IDM system at the OS is describe. The system is based on the methods of biophysical monitoring. A series of the results, obtained during internal exposure individual dose monitoring of the personnel is presented. It is mentioned, that implementation of the internal exposure dose biophysical monitoring system (during the works on transformation of the OS into ecologically safe system allows:  provide adequate level of the IDM of the internal exposure dose (the level is corresponds to the present day requirements of the radiation protection; develop the recommendations on selection of individual means of protection of respiratory tract; ensure determination of the parameters of radioactive air contamination in the work areas; and, provide the optimal planning of dose load to the personnel.

  19. Iron Supplements for Infants at Risk for Iron Deficiency

    Directory of Open Access Journals (Sweden)

    Brianna C. MacQueen MD

    2017-04-01

    Full Text Available Professional societies have published recommendations for iron dosing of preterm neonates, but differences exist between guidelines. To help develop standardized guidelines, we performed a 10-year analysis of iron dosing in groups at risk for iron deficiency: IDM (infants of diabetic mothers, SGA (small for gestational age, and VLBW premature neonates (very low birth weight, <1500 g. We analyzed iron dosing after red cell transfusions and erythropoiesis-stimulating agents (ESA. Of IDM, 11.8% received iron in the hospital; 9.8% of SGA and 27.1% of VLBW neonates received iron. Twenty percent of those who received iron had it started by day 14; 63% by 1 month. Supplemental iron was stopped after red cell transfusions in 73% of neonates receiving iron. An ESA was administered to 1677, of which 33% received iron within 3 days. This marked variation indicates that a consistent approach is needed, and using this report and a literature review, we standardized our iron-dosing guidelines.

  20. Scientific Missions and Technologies of the ISSS on board the NEXTSat-1

    Directory of Open Access Journals (Sweden)

    Cheong Rim Choi

    2014-03-01

    Full Text Available A package of space science instruments, dubbed the Instruments for the Study of Space Storms (ISSS, is proposed for the Next Generation Small Satellite-1 (NEXTSat-1, which is scheduled for launch in May 2016. This paper describes the instrument designs and science missions of the ISSS. The ISSS configuration in NEXTSat-1 is as follows: the space radiation monitoring instruments consist of medium energy particle detector (MEPD and high energy particle detector (HEPD; the space plasma instruments consist of a Langmuir probe (LP, a retarding potential analyzer (RPA, and an ion drift meter (IDM. The space radiation monitoring instruments (MEPD and HEPD measure electrons and protons in parallel and perpendicular directions to the geomagnetic field in the sub-auroral region, and they have a minimum time resolution of 50 msec for locating the region of the particle interactions with whistler mode waves and electromagnetic ion cyclotron (EMIC waves. The MEPD measures electrons and protons with energies of tens of keV to ~400 keV, and the HEPD measures electrons with energies of ~100 keV to > ~1 MeV and protons with energies of ~10 MeV. The space plasma instruments (LP, RPA, and IDM observe irregularities in the low altitude ionosphere, and the results will be compared with the scintillations of the GPS signals. In particular, the LP is designed to have a sampling rate of 50 Hz in order to detect these small-scale irregularities.