WorldWideScience

Sample records for bk060056 antibody check

  1. Antibody

    Science.gov (United States)

    An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples ... microorganisms (bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produced when the immune system mistakenly ...

  2. Check valve

    International Nuclear Information System (INIS)

    A check valve for use in a GDCS of a nuclear reactor and having a motor driven disk including a rotatable armature for rotating the check valve disk over its entire range of motion is described. In one embodiment, the check valve includes a valve body having a coolant flow channel extending therethrough. The coolant flow channel includes an inlet end and an outlet end. A valve body seat is located on an inner surface of the valve body. The check valve further includes a disk assembly, sometimes referred to as the motor driven disc, having a counterweight and a disk shaped valve. The disk valve includes a disk base having a seat for seating with the valve body seat. The disk assembly further includes a first hinge pin member which extends at least partially through the disk assembly and is engaged to the disk. The disk valve is rotatable relative to the first hinge pin member. The check valve also includes a motor having a stator frame with a stator bore therein. An armature is rotatably positioned within the stator bore and the armature is coupled to the disk valve to cause the disk valve to rotate about its full range of motion. 5 figs

  3. Regular health checks

    DEFF Research Database (Denmark)

    Grønhøj Larsen, Christian; Jørgensen, Karsten Juhl; Gøtzsche, Peter C

    2012-01-01

    To investigate whether Danish providers of general health checks present a balanced account of possible benefits and harms on their websites and whether the health checks are evidence-based.......To investigate whether Danish providers of general health checks present a balanced account of possible benefits and harms on their websites and whether the health checks are evidence-based....

  4. Annual Check-up

    Science.gov (United States)

    ... Medical Conditions Nutrition & Fitness Emotional Health Annual Check-Up Posted under Health Guides . Updated 7 January 2015. + ... I get ready for my annual medical check-up? If this is your first visit to your ...

  5. Checking Java Programs

    CERN Document Server

    Darwin, Ian

    2007-01-01

    This Short Cut tells you about tools that will improve the quality of your Java code, using checking above and beyond what the standard tools do, including: Using javac options, JUnit and assertions Making your IDE work harder Checking your source code with PMD Checking your compiled code (.class files) with FindBugs Checking your program's run-time behavior with Java PathFinder

  6. Health Check Tools

    Science.gov (United States)

    ... https://www.nlm.nih.gov/medlineplus/healthchecktools.html Health Check Tools To use the sharing features on ... Schedule (Centers for Disease Control and Prevention) Children's Health Body Mass Index: Calculator for Child and Teen ( ...

  7. Check It Out

    Science.gov (United States)

    ... Materials The Healthy Heart Handbook for Women Check it Out Tests That Can Help Protect Your Heart ... years, or more often if your doctor recommends it. Other Tests There also are several tests that ...

  8. Goat production check list

    DEFF Research Database (Denmark)

    Henriksen, Jørgen; Nielsen, Mette Benedicte Olaf; Madsen, Jørgen;

    2009-01-01

    This check list, financed by DanChurchAid, highlights all issues should be carefully investigated before investing in distribution of goats and in interventions to assist poor rural communities to improve their livelihood through goat production.......This check list, financed by DanChurchAid, highlights all issues should be carefully investigated before investing in distribution of goats and in interventions to assist poor rural communities to improve their livelihood through goat production....

  9. Check valves aging assessment

    International Nuclear Information System (INIS)

    In support of the NRC Nuclear Plant Aging Research (NPAR) program, the Oak Ridge National Laboratory (ORNL) has carried out an assessment of several check value diagnostic monitoring methods, in particular, those based on measurements of acoustic emission, ultrasonics, and magnetic flux. The evaluations have focussed on the capabilities of each method to provide information useful in determining check valve aging and service wear effects, check valve failures, and undesirable operating modes. This paper describes the benefits and limitations associated with each method and includes recent laboratory and field test data, including data obtained from the vendors who recently participated in a comprehensive series of tests directed by a nuclear industry users group. In addition, as part of the ORNL Advanced Diagnostic Engineering Research and Development Center (ADEC), two novel nonintrusive monitoring methods were developed that provide several unique capabilities. These methods, based on external ac- an dc-magnetic monitoring are also described. None of the examined methods could, by themselves, monitor both the instantaneous position and motion of check valve internals and valve leakage; however, the combination of acoustic emission monitoring with one of the other methods provides the means to determine vital check valve operational information

  10. CMM Interim Check (U)

    Energy Technology Data Exchange (ETDEWEB)

    Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-23

    Coordinate Measuring Machines (CMM) are widely used in industry, throughout the Nuclear Weapons Complex and at Los Alamos National Laboratory (LANL) to verify part conformance to design definition. Calibration cycles for CMMs at LANL are predominantly one year in length. Unfortunately, several nonconformance reports have been generated to document the discovery of a certified machine found out of tolerance during a calibration closeout. In an effort to reduce risk to product quality two solutions were proposed – shorten the calibration cycle which could be costly, or perform an interim check to monitor the machine’s performance between cycles. The CMM interim check discussed makes use of Renishaw’s Machine Checking Gauge. This off-the-shelf product simulates a large sphere within a CMM’s measurement volume and allows for error estimation. Data was gathered, analyzed, and simulated from seven machines in seventeen different configurations to create statistical process control run charts for on-the-floor monitoring.

  11. Checking for Ketones

    Science.gov (United States)

    ... by Mail Close www.diabetes.org > Living With Diabetes > Treatment and Care > Blood Glucose Testing Share: Print Page Text Size: ... glucose-and-a1c, In this section Living With Diabetes Treatment and Care Blood Glucose Testing Checking Your Blood Glucose A1C ...

  12. Swing check valve

    International Nuclear Information System (INIS)

    A swing check valve which includes a valve body having an inlet and outlet is described. A recess in the valve body designed to hold a seal ring and a check valve disc swingable between open and closed positions. The disc is supported by a high strength wire secured at one end in a support spacer pinned through bearing blocks fixed to the valve body and at its other end in a groove formed on the outer peripheral surface of the disc. The parts are designed and chosen such to provide a lightweight valve disc which is held open by minimum velocity of fluid flowing through the valve which thus reduces oscillations and accompanying wear of bearings supporting the valve operating parts. (Auth.)

  13. Keeping valves in check

    International Nuclear Information System (INIS)

    Check valves are located in almost all safety and non-safety related fluid systems in a nuclear power plant. Malfunction or failure of these valves during plant operations, or in some cases under cold shutdown conditions, can seriously affect plant safety and result in costly, time-consuming maintenance. A major cause of check valve failure in the past has been excessive wear of internal components due to high disc flutter. Valve operation under conditions that cause the valve disc and hinge arm to oscillate or flutter can lead to degradations which, if undetected and not corrected, may result in malfunction or failure. Checkmate II, a portable, non-intrusive diagnostic system, has been developed to test various types of check valves using patented ultrasonic testing technology. The system comprises a computer, ultrasonic oscilloscope, transducers, and supporting hardware, and can identify many different phenomena, including: disc position and disc flutter; backstop and seat tapping; relative motion between hinge arm and disc; hinge pin wear and uneven hinge pin wear; disc stud wear and loosened stud nuts; combined stud and hinge pin wear, stuck and missing discs; broken springs. (author)

  14. Checking Model Transformation Refinement

    OpenAIRE

    Büttner, Fabian; Egea, Marina; Guerra, Esther; Lara, Juan De

    2013-01-01

    The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-38883-5_15 Proceedings of 6th International Conference, ICMT 2013, Budapest, Hungary, June 18-19, 2013 Refinement is a central notion in computer science, meaning that some artefact S can be safely replaced by a refinement R, which preserves S’s properties. Having available techniques and tools to check transformation refinement would enable (a) the reasoning on whether a transformation correctly impl...

  15. Bounded Model Checking of CTL

    Institute of Scientific and Technical Information of China (English)

    Zhi-Hong Tao; Cong-Hua Zhou; Zhong Chen; Li-Fu Wang

    2007-01-01

    Bounded Model Checking has been recently introduced as an efficient verification method for reactive systems.This technique reduces model checking of linear temporal logic to propositional satisfiability.In this paper we first present how quantified Boolean decision procedures can replace BDDs.We introduce a bounded model checking procedure for temporal logic CTL* which reduces model checking to the satisfiability of quantified Boolean formulas.Our new technique avoids the space blow up of BDDs, and extends the concept of bounded model checking.

  16. 14 CFR 91.1093 - Initial and transition training and checking: Check pilots (aircraft), check pilots (simulator).

    Science.gov (United States)

    2010-01-01

    ... checking: Check pilots (aircraft), check pilots (simulator). 91.1093 Section 91.1093 Aeronautics and Space....1093 Initial and transition training and checking: Check pilots (aircraft), check pilots (simulator... observation check may be accomplished in part or in full in an aircraft, in a flight simulator, or in a...

  17. Checking Security Policy Compliance

    CERN Document Server

    Gowadia, Vaibhav; Kudo, Michiharu

    2008-01-01

    Ensuring compliance of organizations to federal regulations is a growing concern. This paper presents a framework and methods to verify whether an implemented low-level security policy is compliant to a high-level security policy. Our compliance checking framework is based on organizational and security metadata to support refinement of high-level concepts to implementation specific instances. Our work uses the results of refinement calculus to express valid refinement patterns and their properties. Intuitively, a low-level security policy is compliant to a high-level security policy if there is a valid refinement path from the high-level security policy to the low-level security policy. Our model is capable of detecting violations of security policies, failures to meet obligations, and capability and modal conflicts.

  18. Thyroid Antibodies

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? Thyroid Antibodies Share this page: Was this page helpful? Also known as: Thyroid Autoantibodies; Antithyroid Antibodies; Antimicrosomal Antibody; Thyroid Microsomal Antibody; ...

  19. 14 CFR 135.339 - Initial and transition training and checking: Check airmen (aircraft), check airmen (simulator).

    Science.gov (United States)

    2010-01-01

    ... checking: Check airmen (aircraft), check airmen (simulator). 135.339 Section 135.339 Aeronautics and Space... and checking: Check airmen (aircraft), check airmen (simulator). (a) No certificate holder may use a... an aircraft, in a flight simulator, or in a flight training device. This paragraph applies...

  20. Compositional and Quantitative Model Checking

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand

    This paper gives a survey of a composition model checking methodology and its succesfull instantiation to the model checking of networks of finite-state, timed, hybrid and probabilistic systems with respect; to suitable quantitative versions of the modal mu-calculus [Koz82]. The method is based on...

  1. Model Checking as Static Analysis

    DEFF Research Database (Denmark)

    Zhang, Fuyuan

    properties which can predict safe approximations to program behaviors. In this thesis, we have developed several static analysis based techniques to solve model checking problems, aiming at showing the link between static analysis and model checking. We focus on logical approaches to static analysis......Both model checking and static analysis are prominent approaches to detecting software errors. Model Checking is a successful formal method for verifying properties specified in temporal logics with respect to transition systems. Static analysis is also a powerful method for validating program...... multi-valued setting, and we therefore obtain a multivalued analysis for temporal properties specied by CTL formulas. In particular, we have shown that the three-valued CTL model checking problem over Kripke modal transition systems can be exactly encoded in three-valued ALFP. Last, we come back to two...

  2. Scram system with continuos check

    International Nuclear Information System (INIS)

    The equipment described pretends to be a further step to the use of integrated circuits in nuclear instrumentation, considering that this type of control was traditionally carried out on the bases of electromechanical elements. A continuous self-check method has been applied in accordance with the high reliability requiered for this type of equipments. The developed equipment fulfils the condition that any deficiency in its component elements, causes an anormal self-detected operation. The equipment covers two systems: the Scram one, that includes the sequence generator-detector, the rods check and scram chain, and the Check system that uses pulses from the sequence detector. (author)

  3. New methods of concurrent checking

    CERN Document Server

    Goessel, Michael; Sogomonyan, Egor; Marienfeld, Daniel

    2008-01-01

    Written by a team of two leading experts and two very successful young former PhD students, New Methods of Concurrent Checking describes new methods of concurrent checking, such as partial duplication, use of output dependencies, complementary circuits, self-dual parity, self-dual duplication and others. A special chapter demonstrates how the new general methods of concurrent checking can be more specifically applied to regular structures to obtain optimum results. This is exemplified for all types of adders up to 64 bits with a level of detail never before presented in the literature. The cle

  4. Model Checking Algorithms for CTMDPs

    DEFF Research Database (Denmark)

    Buchholz, Peter; Hahn, Ernst Moritz; Hermanns, Holger;

    2011-01-01

    Continuous Stochastic Logic (CSL) can be interpreted over continuoustime Markov decision processes (CTMDPs) to specify quantitative properties of stochastic systems that allow some external control. Model checking CSL formulae over CTMDPs requires then the computation of optimal control strategie...

  5. Treasury Check Verification Query (TCVQ)

    Data.gov (United States)

    Social Security Administration — The TCVQ system determines the SSN of an individual whose check has been returned to a local field office. The FO is able to request this information via the TCVQ...

  6. Advances in Probabilistic Model Checking

    OpenAIRE

    Kwiatkowska, Marta; Parker, David

    2012-01-01

    Probabilistic model checking is an automated verification method that aims to establish the correctness of probabilistic systems. Probability may arise, for example, due to failures of unreliable components, communication across lossy media, or through the use of randomisation in distributed protocols. Probabilistic model checking enables a range of exhaustive, quantitative analyses of properties such as "the probability of a message being delivered within 5ms is at least 0.89". In the last t...

  7. Model checking PSL safety properties

    OpenAIRE

    Launiainen, Tuomas

    2009-01-01

    Model checking is a modern, efficient approach to gaining confidence of the correctness of complex systems. It outperforms conventional testing methods especially in cases where a high degree of confidence in the correctness of the system is required, or when the test runs of the system are difficult to reproduce accurately. In model checking the system is verified against a specification that is expressed in a formal specification language. The main challenges are that the process requires q...

  8. Community perspectives: Community check cashing

    OpenAIRE

    Daniel Leibsohn

    2011-01-01

    In May of 2009, Community Development Finance (CDF) opened the first nonprofit, full-service check cashing store in the country in Fruitvale, California. The project is designed to provide low-income households with the financial services they need, without the asset-stripping characteristics common to the fringe banking industry. In addition to providing affordable check cashing services and a payday loan product, CDF also provides financial coaching and literacy training, small business ass...

  9. Model composition in model checking

    OpenAIRE

    Felscher, Ingo

    2014-01-01

    Model-checking allows one to formally check properties of systems: these properties are modeled as logic formulas and the systems as structures like transition systems. These transition systems are often composed, i.e., they arise in form of products or sums. The composition technique allows us to deduce the truth of a formula in the composed system from "interface information": the truth of formulas for the component systems and information in which components which of these formulas hold. W...

  10. Body checking behaviors in men

    OpenAIRE

    Walker, D. Catherine; Anderson, Drew A.; Hildebrandt, Thomas

    2009-01-01

    Males have been facing increasing pressure from the media to attain a lean, muscular physique, and are at risk for body dissatisfaction, disturbed eating and exercise behaviors, and abuse of appearance- and performance-enhancing drugs (APEDs). The aim of the current study was to examine the relationship between body checking and mood, symptoms of muscle dysmorphia, importance of shape and weight, and APED use in undergraduate males. Body checking in males was correlated with weight and shape ...

  11. Uncertainty in Cross Orthogonality Checks

    Science.gov (United States)

    Matsumura, Yuichi

    Finite element structural dynamic models are typically validated using data obtained from a modal testing. Although it is known that test variability may affect the verification, the test variability is typically ignored in the verification process. This paper describes the sensitivities of cross orthogonality check to the test variability. The cross orthogonality check is one of correlation techniques which is gaining acceptance in the structural dynamics community, because of its improved accuracy over the standard modal assurance criterion. Then an uncertainty index of the cross orthogonality check is proposed based on the fact that the sensitivities are much dependent on sensor placement. The results of some artificially generated test cases are presented to demonstrate the applicability of the proposed approach.

  12. Direct Model Checking Matrix Algorithm

    Institute of Scientific and Technical Information of China (English)

    Zhi-Hong Tao; Hans Kleine Büning; Li-Fu Wang

    2006-01-01

    During the last decade, Model Checking has proven its efficacy and power in circuit design, network protocol analysis and bug hunting. Recent research on automatic verification has shown that no single model-checking technique has the edge over all others in all application areas. So, it is very difficult to determine which technique is the most suitable for a given model. It is thus sensible to apply different techniques to the same model. However, this is a very tedious and time-consuming task, for each algorithm uses its own description language. Applying Model Checking in software design and verification has been proved very difficult. Software architectures (SA) are engineering artifacts that provide high-level and abstract descriptions of complex software systems. In this paper a Direct Model Checking (DMC) method based on Kripke Structure and Matrix Algorithm is provided. Combined and integrated with domain specific software architecture description languages (ADLs), DMC can be used for computing consistency and other critical properties.

  13. From preventive to permissive checks

    DEFF Research Database (Denmark)

    Weisdorf, Jacob Louis; Sharp, Paul Richard

    2009-01-01

    The Malthusian "preventive check" mechanism has been well documented for pre-industrial England through evidence for a negative correlation between the marriage rate and the price of wheat. Other literature, however, speculates that the correlation was in fact positive from the early nineteenth...

  14. Antithyroid microsomal antibody

    Science.gov (United States)

    Thyroid antimicrosomal antibody; Antimicrosomal antibody; Microsomal antibody; Thyroid peroxidase antibody; TPOAb ... Granulomatous thyroiditis Hashimoto thyroiditis High levels of these antibodies have also been linked to an increased risk ...

  15. Transaction management with integrity checking

    DEFF Research Database (Denmark)

    Martinenghi, Davide; Christiansen, Henning

    2005-01-01

    Database integrity constraints, understood as logical conditions that must hold for any database state, are not fully supported by current database technology. It is typically up to the database designer and application programmer to enforce integrity via triggers or tests at the application level......, which are difficult to maintain and error prone. Two important aspects must be taken care of. 1.~It is too time consuming to check integrity constraints from scratch after each update, so simplified checks before each update should be used relying on the assumption that the current state is consistent....... 2.~In concurrent database systems, besides the traditional correctness criterion, the execution schedule must ensure that the different transactions can overlap in time without destroying the consistency requirements tested by other, concurrent transactions....

  16. From Preventive to Permissive Checks

    DEFF Research Database (Denmark)

    Sharp, Paul Richard; Weisdorf, Jacob Louis

    The Malthusian "preventive check" mechanism has been well documented for pre-industrial England through evidence for a negativcorrelation between the marriage rate and the price of wheat. Other literature, however, speculates that the correlation was in fact positive from the early nineteenth cen...... shows that this result is not in fact inconsistent with a stylized Malthusian mechanism, and can be understood within the context of an increasing dominance of shocks to aggregate demand rather than to aggregate supply...

  17. Program Analysis as Model Checking

    DEFF Research Database (Denmark)

    Olesen, Mads Chr.

    of an abstract interpretation. For the generalisation to lattice automata to have benefit it is important that efficient tools exist. This thesis presents multi-core tools for efficient and scalable reachability and Büchi emptiness checking of timed/lattice automata. Finally, a number of case studies...... overapproximation of the hardware is needed; the case of identifying timing anomalous hardware for which such abstractions are hard to find is considered....

  18. Checking modes of HAL programs

    OpenAIRE

    de la Banda, MG; Harvey, W; Marriott, K.; Stuckey, PJ; Demoen, Bart

    2005-01-01

    Recent constraint logic programming (CLP) languages, such as HAL and Mercury, require type, mode and determinism declarations for predicates. This information allows the generation of efficient target code and the detection of many errors at compile-time. Unfortunately, mode checking in such languages is difficult. One of the main reasons is that, for each predicate mode declaration, the compiler is required to appropriately re-order literals in the predicate's definition. The task is further...

  19. Quality of histone modification antibodies undermines chromatin biology research

    OpenAIRE

    Goran Kungulovski; Albert Jeltsch

    2015-01-01

    Histone post-translational modification (PTM) antibodies are essential research reagents in chromatin biology. However, they suffer from variable properties and insufficient documentation of quality. Antibody manufacturers and vendors should provide detailed lot-specific documentation of quality, rendering further quality checks by end-customers unnecessary. A shift from polyclonal antibodies towards sustainable reagents like monoclonal or recombinant antibodies or histone binding domains wou...

  20. 25 CFR 141.19 - Check cashing.

    Science.gov (United States)

    2010-04-01

    ... may give a fully negotiable check in addition to U.S. currency when cashing a draft, check or money... or any other obligation the customer owes to the business, but in no event may the owner or...

  1. Checking Out Cuts, Scratches, and Abrasions

    Science.gov (United States)

    ... Skating Crushes What's a Booger? Checking Out Cuts, Scratches, and Abrasions KidsHealth > For Kids > Checking Out Cuts, ... weren't wearing kneepads. How Do Cuts and Scratches Heal? After getting a cut, scratch, or abrasion, ...

  2. 14 CFR 91.1089 - Qualifications: Check pilots (aircraft) and check pilots (simulator).

    Science.gov (United States)

    2010-01-01

    ... check pilots (simulator). 91.1089 Section 91.1089 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... (aircraft) and check pilots (simulator). (a) For the purposes of this section and § 91.1093: (1) A check... simulator, or in a flight training device for a particular type aircraft. (2) A check pilot (simulator) is...

  3. 14 CFR 121.411 - Qualifications: Check airmen (airplane) and check airmen (simulator).

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Qualifications: Check airmen (airplane) and... § 121.411 Qualifications: Check airmen (airplane) and check airmen (simulator). (a) For the purposes of this section and § 121.413: (1) A check airman (airplane) is a person who is qualified, and...

  4. Anonymity control in electronic check systems

    Institute of Scientific and Technical Information of China (English)

    Ma Chunguang; Yang Yixian; Hu Zhengming

    2005-01-01

    Electronic check systems, as one of electronic payment systems, are more desirable than other electronic cash systems. In the system, only a single check is used to pay any price that is not more than the face value. The main problem in check systems is to design an efficient refund mechanism that makes refund checks undistinguished from initial checks during payment and deposit. The problem of anonymity control also called fairness is also an important issue in check systems. All check systems yet are unconditional anonymity that opens the door to misuse for crime such as laundering and blackmailing. In this paper, the notion of anonymity revocation is introduced to electronic check system for the first time, and a model of fair electronic check system is proposed. An efficient fair online electronic check system with reusable refund is presented. In the system, a passive trustee is employed to revoke the anonymity of un-honest users. Moreover, the system solves the reusability problem of refunds thanks to the RSA-based partially signature. The system is efficient and meets all basic security requirements.

  5. Heteroscedasticity checks for regression models

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    For checking on heteroscedasticity in regression models, a unified approach is proposed to constructing test statistics in parametric and nonparametric regression models. For nonparametric regression, the test is not affected sensitively by the choice of smoothing parameters which are involved in estimation of the nonparametric regression function. The limiting null distribution of the test statistic remains the same in a wide range of the smoothing parameters. When the covariate is one-dimensional, the tests are, under some conditions, asymptotically distribution-free. In the high-dimensional cases, the validity of bootstrap approximations is investigated. It is shown that a variant of the wild bootstrap is consistent while the classical bootstrap is not in the general case, but is applicable if some extra assumption on conditional variance of the squared error is imposed. A simulation study is performed to provide evidence of how the tests work and compare with tests that have appeared in the literature. The approach may readily be extended to handle partial linear, and linear autoregressive models.

  6. Control-flow checking via regular expressions

    OpenAIRE

    Benso, Alfredo; Di Natale, Giorgio; Di Carlo, Stefano; Prinetto, Paolo Ernesto; Tagliaferri, Luca

    2001-01-01

    The present paper explains a new approach to program control flow checking. The check has been inserted at source-code level using a signature methodology based on regular expressions. The signature checking is performed without a dedicated watchdog processor but resorting to inter-process communication (IPC) facilities offered by most of the modern operating systems. The proposed approach allows very low memory overhead and trade-off between fault latency and program execution time overhead

  7. An experimental analysis of body checking

    OpenAIRE

    Shafran, Roz; Lee, Michelle; Payne, Elizabeth; Fairburn, Christopher G.

    2007-01-01

    The relationship between repeated body checking and its impact on body size estimation and body dissatisfaction is of interest for two reasons. First, it has importance in theoretical accounts of the maintenance of eating disorders and, second, body checking is targeted in cognitive-behavioural treatment. The aim of this study was to determine the impact of manipulating body checking on body size estimation and body dissatisfaction. Sixty women were randomly assigned either to repeatedly scru...

  8. Check valve slam analysis in pumping station

    OpenAIRE

    Himr D.; Habán V.; Dokoupil P.

    2016-01-01

    Pumping station supplies water for technological process. The check valve in the station was replaced with a new one. The regular test of black out discovered the high pressure pulsations accompanied with noticeable pipeline movement of discharge pipe. It was caused by late check valve closing, probably, when the back flow reached the highest possible velocity. This statement was supported with analysis of results of pressure measurement near the check valve and with a numerical simulation of...

  9. Check valve slam analysis in pumping station

    Science.gov (United States)

    Himr, D.; Habán, V.; Dokoupil, P.

    2016-03-01

    Pumping station supplies water for technological process. The check valve in the station was replaced with a new one. The regular test of black out discovered the high pressure pulsations accompanied with noticeable pipeline movement of discharge pipe. It was caused by late check valve closing, probably, when the back flow reached the highest possible velocity. This statement was supported with analysis of results of pressure measurement near the check valve and with a numerical simulation of the flow in the pipeline system.

  10. Heteroscedasticity checks for regression models

    Institute of Scientific and Technical Information of China (English)

    ZHU; Lixing

    2001-01-01

    [1]Carroll, R. J., Ruppert, D., Transformation and Weighting in Regression, New York: Chapman and Hall, 1988.[2]Cook, R. D., Weisberg, S., Diagnostics for heteroscedasticity in regression, Biometrika, 1988, 70: 1—10.[3]Davidian, M., Carroll, R. J., Variance function estimation, J. Amer. Statist. Assoc., 1987, 82: 1079—1091.[4]Bickel, P., Using residuals robustly I: Tests for heteroscedasticity, Ann. Statist., 1978, 6: 266—291.[5]Carroll, R. J., Ruppert, D., On robust tests for heteroscedasticity, Ann. Statist., 1981, 9: 205—209.[6]Eubank, R. L., Thomas, W., Detecting heteroscedasticity in nonparametric regression, J. Roy. Statist. Soc., Ser. B, 1993, 55: 145—155.[7]Diblasi, A., Bowman, A., Testing for constant variance in a linear model, Statist. and Probab. Letters, 1997, 33: 95—103.[8]Dette, H., Munk, A., Testing heteoscedasticity in nonparametric regression, J. R. Statist. Soc. B, 1998, 60: 693—708.[9]Müller, H. G., Zhao, P. L., On a semi-parametric variance function model and a test for heteroscedasticity, Ann. Statist., 1995, 23: 946—967.[10]Stute, W., Manteiga, G., Quindimil, M. P., Bootstrap approximations in model checks for regression, J. Amer. Statist. Asso., 1998, 93: 141—149.[11]Stute, W., Thies, G., Zhu, L. X., Model checks for regression: An innovation approach, Ann. Statist., 1998, 26: 1916—1939.[12]Shorack, G. R., Wellner, J. A., Empirical Processes with Applications to Statistics, New York: Wiley, 1986.[13]Efron, B., Bootstrap methods: Another look at the jackknife, Ann. Statist., 1979, 7: 1—26.[14]Wu, C. F. J., Jackknife, bootstrap and other re-sampling methods in regression analysis, Ann. Statist., 1986, 14: 1261—1295.[15]H rdle, W., Mammen, E., Comparing non-parametric versus parametric regression fits, Ann. Statist., 1993, 21: 1926—1947.[16]Liu, R. Y., Bootstrap procedures under some non-i.i.d. models, Ann. Statist., 1988, 16: 1696—1708.[17

  11. Bispecific antibodies.

    Science.gov (United States)

    Kontermann, Roland E; Brinkmann, Ulrich

    2015-07-01

    Bispecific antibodies (bsAbs) combine specificities of two antibodies and simultaneously address different antigens or epitopes. BsAbs with 'two-target' functionality can interfere with multiple surface receptors or ligands associated, for example with cancer, proliferation or inflammatory processes. BsAbs can also place targets into close proximity, either to support protein complex formation on one cell, or to trigger contacts between cells. Examples of 'forced-connection' functionalities are bsAbs that support protein complexation in the clotting cascade, or tumor-targeted immune cell recruiters and/or activators. Following years of research and development (R&D), the first bsAb was approved in 2009. Another bsAb entered the market in December 2014 and several more are in clinical trials. Here, we describe the potentials of bsAbs to become the next wave of antibody-based therapies, focusing on molecules in clinical development. PMID:25728220

  12. Check-In Check-Out + Social Skills: Enhancing the Effects of Check-In Check-Out for Students With Social Skill Deficits

    Science.gov (United States)

    Ross, Scott W.; Sabey, Christian V.

    2015-01-01

    Check-In Check-Out is a Tier 2 intervention designed to reduce problem behavior and increase prosocial behavior. Although the intervention has demonstrated effects in several studies, few research efforts have considered how the intervention can be modified to support students with social skill deficits. Through a multiple baseline design across…

  13. 7 CFR 58.243 - Checking quality.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Checking quality. 58.243 Section 58.243 Agriculture... Procedures § 58.243 Checking quality. All milk, milk products and dry milk products shall be subject to inspection and analysis by the dairy plant for quality and condition throughout each processing...

  14. Tractor Mechanic Check Sheets for Modules.

    Science.gov (United States)

    Clemson Univ., SC. Vocational Education Media Center.

    Forms for student self-checks and the instructor's final checklist (student evaluation) are provided for use with thirty-three learning modules on maintaining and servicing fuel and electrical systems in tractor mechanics. The student self-check asks the students questions about their understanding of the modules' content. The instructor's…

  15. Vertical pump with free floating check valve

    International Nuclear Information System (INIS)

    A vertical pump is described which has a bottom discharge with a free floating check valve disposed in the outlet plenum thereof. The free floating check valve comprises a spherical member with a hemispherical cage-like member attached thereto which is capable of allowing forward or reverse flow under appropriate conditions while preventing reverse flow under inappropriate conditions

  16. The model checking fingerprints of CTL operators

    OpenAIRE

    Krebs, Andreas; Meier, Arne; Mundhenk, Martin

    2015-01-01

    The aim of this study is to understand the inherent expressive power of CTL operators. We investigate the complexity of model checking for all CTL fragments with one CTL operator and arbitrary Boolean operators. This gives us a fingerprint of each CTL operator. The comparison between the fingerprints yields a hierarchy of the operators that mirrors their strength with respect to model checking.

  17. Automatization and familiarity in repeated checking

    NARCIS (Netherlands)

    Dek, E.C.P.; van den Hout, M.A.; Giele, C.L.; Engelhard, I.M.

    2015-01-01

    Repetitive, compulsive-like checking of an object leads to reductions in memory confidence, vividness, and detail. Experimental research suggests that this is caused by increased familiarity with perceptual characteristics of the stimulus and automatization of the checking procedure (Dek, van den Ho

  18. QuickChecking Static Analysis Properties

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Møller, Anders

    2015-01-01

    A static analysis can check programs for potential errors. A natural question that arises is therefore: who checks the checker? Researchers have given this question varying attention, ranging from basic testing techniques, informal monotonicity arguments, thorough pen-and-paper soundness proofs, ...

  19. Arithmetic Operand Ordering for Equivalence Checking

    Institute of Scientific and Technical Information of China (English)

    WENG Yanling; GE Haitong; YAN Xiaolang; Ren Kun

    2007-01-01

    An information extraction-based technique is proposed for RTL-to-gate equivalence checking. Distances are calculated on directed acyclic graph (AIG). Multiplier and multiplicand are distinguished on multiplications with different coding methods, with which the operand ordering/grouping information could be extracted from a given implementation gate netlist, helping the RTL synthesis engine generate a gate netlist with great similarity. This technique has been implemented in an internal equivalence checking tool, ZD_VIS. Compared with the simple equivalence checking, the speed is accelerated by at least 40% in its application to a class of arithmetic designs, addition and multiplication trees. The method can be easily incorporated into existing RTL-to-gate equivalence checking frameworks, increasing the robustness of equivalence checking for arithmetic circuits.

  20. 14 CFR 135.337 - Qualifications: Check airmen (aircraft) and check airmen (simulator).

    Science.gov (United States)

    2010-01-01

    ... check airmen (simulator). 135.337 Section 135.337 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... (simulator). (a) For the purposes of this section and § 135.339: (1) A check airman (aircraft) is a person who is qualified to conduct flight checks in an aircraft, in a flight simulator, or in a...

  1. Simple Check Valves for Microfluidic Devices

    Science.gov (United States)

    Willis, Peter A.; Greer, Harold F.; Smith, J. Anthony

    2010-01-01

    A simple design concept for check valves has been adopted for microfluidic devices that consist mostly of (1) deformable fluorocarbon polymer membranes sandwiched between (2) borosilicate float glass wafers into which channels, valve seats, and holes have been etched. The first microfluidic devices in which these check valves are intended to be used are micro-capillary electrophoresis (microCE) devices undergoing development for use on Mars in detecting compounds indicative of life. In this application, it will be necessary to store some liquid samples in reservoirs in the devices for subsequent laboratory analysis, and check valves are needed to prevent cross-contamination of the samples. The simple check-valve design concept is also applicable to other microfluidic devices and to fluidic devices in general. These check valves are simplified microscopic versions of conventional rubber- flap check valves that are parts of numerous industrial and consumer products. These check valves are fabricated, not as separate components, but as integral parts of microfluidic devices. A check valve according to this concept consists of suitably shaped portions of a deformable membrane and the two glass wafers between which the membrane is sandwiched (see figure). The valve flap is formed by making an approximately semicircular cut in the membrane. The flap is centered over a hole in the lower glass wafer, through which hole the liquid in question is intended to flow upward into a wider hole, channel, or reservoir in the upper glass wafer. The radius of the cut exceeds the radius of the hole by an amount large enough to prevent settling of the flap into the hole. As in a conventional rubber-flap check valve, back pressure in the liquid pushes the flap against the valve seat (in this case, the valve seat is the adjacent surface of the lower glass wafer), thereby forming a seal that prevents backflow.

  2. Incremental Integrity Checking: Limitations and Possibilities

    DEFF Research Database (Denmark)

    Christiansen, Henning; Martinenghi, Davide

    2005-01-01

    Integrity checking is an essential means for the preservation of the intended semantics of a deductive database. Incrementality is the only feasible approach to checking and can be obtained with respect to given update patterns by exploiting query optimization techniques. By reducing the problem to...... query containment, we show that no procedure exists that always returns the best incremental test (aka simplification of integrity constraints), and this according to any reasonable criterion measuring the checking effort. In spite of this theoretical limitation, we develop an effective procedure...

  3. Why your practice must do background checks.

    Science.gov (United States)

    Zupko, Karen

    2007-01-01

    Hiring qualified staff is critical for a medical practice. As many physicians have discovered, taking applicants' resumes on faith can be a mistake. Background company searches show that one in three applicants provide false, inaccurate, misleading, or incomplete information. Fake degrees, false licenses and certifications, and criminal histories are a few of the problems that a proper background check can reveal. This article describes further why background checks are essential, how to incorporate a background check into your hiring process, and some of the legalities involved in the process. PMID:17494489

  4. Check valve slam analysis in pumping station

    Directory of Open Access Journals (Sweden)

    Himr D.

    2016-01-01

    Full Text Available Pumping station supplies water for technological process. The check valve in the station was replaced with a new one. The regular test of black out discovered the high pressure pulsations accompanied with noticeable pipeline movement of discharge pipe. It was caused by late check valve closing, probably, when the back flow reached the highest possible velocity. This statement was supported with analysis of results of pressure measurement near the check valve and with a numerical simulation of the flow in the pipeline system.

  5. Automatic check of the RFX machine signals

    International Nuclear Information System (INIS)

    The paper deals with an automatic computer procedure developed to detect errors or faults in the signal waveforms measured during the operation of the RFX machine. These data are generated by the diagnostic equipment and other sensors installed in the machine and in its power supplies. The signal check is paramount, since even a single faulty waveform may lead to wrong results in the post-processing phase. Due to their large number, the manual inspection of each signal after the pulse is impossible. The check has to be performed as quickly as possible, in order to identify and discard the defective waveforms before their on-line elaboration. To this purpose, the on-line signal check program is integrated in the control data acquisition system of RFX. Presently, the procedure is being used to check the quality of the saved machine pulse data

  6. Computational fact checking from knowledge networks

    CERN Document Server

    Ciampaglia, Giovanni Luca; Rocha, Luis M; Bollen, Johan; Menczer, Filippo; Flammini, Alessandro

    2015-01-01

    Traditional fact checking by expert journalists cannot keep up with the enormous volume of information that is now generated online. Computational fact checking may significantly enhance our ability to evaluate the veracity of dubious information. Here we show that the complexities of human fact checking can be approximated quite well by finding the shortest path between concept nodes under properly defined semantic proximity metrics on knowledge graphs. Framed as a network problem this approach is feasible with efficient computational techniques. We evaluate this approach by examining tens of thousands of claims related to history, entertainment, geography, and biographical information using a public knowledge graph extracted from Wikipedia. Statements independently known to be true consistently receive higher support via our method than do false ones. These findings represent a significant step toward scalable computational fact-checking methods that may one day mitigate the spread of harmful misinformation...

  7. Computational Fact Checking from Knowledge Networks.

    Directory of Open Access Journals (Sweden)

    Giovanni Luca Ciampaglia

    Full Text Available Traditional fact checking by expert journalists cannot keep up with the enormous volume of information that is now generated online. Computational fact checking may significantly enhance our ability to evaluate the veracity of dubious information. Here we show that the complexities of human fact checking can be approximated quite well by finding the shortest path between concept nodes under properly defined semantic proximity metrics on knowledge graphs. Framed as a network problem this approach is feasible with efficient computational techniques. We evaluate this approach by examining tens of thousands of claims related to history, entertainment, geography, and biographical information using a public knowledge graph extracted from Wikipedia. Statements independently known to be true consistently receive higher support via our method than do false ones. These findings represent a significant step toward scalable computational fact-checking methods that may one day mitigate the spread of harmful misinformation.

  8. For Better Skin Cancer Checks, Partner Up

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_159632.html For Better Skin Cancer Checks, Partner Up Melanoma survivors benefited when they ... out: Getting a partner trained to spot potential skin cancers can be a lifesaver for melanoma survivors, a ...

  9. Computational Fact Checking from Knowledge Networks

    Science.gov (United States)

    Ciampaglia, Giovanni Luca; Shiralkar, Prashant; Rocha, Luis M.; Bollen, Johan; Menczer, Filippo; Flammini, Alessandro

    2015-01-01

    Traditional fact checking by expert journalists cannot keep up with the enormous volume of information that is now generated online. Computational fact checking may significantly enhance our ability to evaluate the veracity of dubious information. Here we show that the complexities of human fact checking can be approximated quite well by finding the shortest path between concept nodes under properly defined semantic proximity metrics on knowledge graphs. Framed as a network problem this approach is feasible with efficient computational techniques. We evaluate this approach by examining tens of thousands of claims related to history, entertainment, geography, and biographical information using a public knowledge graph extracted from Wikipedia. Statements independently known to be true consistently receive higher support via our method than do false ones. These findings represent a significant step toward scalable computational fact-checking methods that may one day mitigate the spread of harmful misinformation. PMID:26083336

  10. Consistency Checking of Web Service Contracts

    DEFF Research Database (Denmark)

    Cambronero, M. Emilia; Okika, Joseph C.; Ravn, Anders Peter

    2008-01-01

    Behavioural properties are analyzed for web service contracts formulated in Business Process Execution Language (BPEL) and Choreography Description Language (CDL). The key result reported is an automated technique to check consistency between protocol aspects of the contracts. The contracts are...

  11. CMM Interim Check Design of Experiments (U)

    Energy Technology Data Exchange (ETDEWEB)

    Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-29

    Coordinate Measuring Machines (CMM) are widely used in industry, throughout the Nuclear Weapons Complex and at Los Alamos National Laboratory (LANL) to verify part conformance to design definition. Calibration cycles for CMMs at LANL are predominantly one year in length and include a weekly interim check to reduce risk. The CMM interim check makes use of Renishaw’s Machine Checking Gauge which is an off-the-shelf product simulates a large sphere within a CMM’s measurement volume and allows for error estimation. As verification on the interim check process a design of experiments investigation was proposed to test a couple of key factors (location and inspector). The results from the two-factor factorial experiment proved that location influenced results more than the inspector or interaction.

  12. Health Check Tools: MedlinePlus

    Science.gov (United States)

    ... of this page: https://medlineplus.gov/healthchecktools.html Health Check Tools To use the sharing features on ... Schedule (Centers for Disease Control and Prevention) Children's Health Body Mass Index: Calculator for Child and Teen ( ...

  13. Engineering Abstractions in Model Checking and Testing

    OpenAIRE

    Achenbach, Michael; Ostermann, Klaus

    2009-01-01

    Abstractions are used in model checking to tackle problems like state space explosion or modeling of IO. The application of these abstractions in real software development processes, however, lacks engineering support. This is one reason why model checking is not widely used in practice yet and testing is still state of the art in falsification. We show how user-defined abstractions can be integrated into a Java PathFinder setting with tools like AspectJ or Javassist and discuss implicati...

  14. Check Point认证简介

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Check Point软件技术有限公司是因特网安全领域的全球著名企业,占有全球65%VPN/防火墙市场份额(IDC 2002),财富前100强中有97家公司采用Check Point的安全产品。

  15. Online treatment compliance checking for clinical pathways.

    Science.gov (United States)

    Huang, Zhengxing; Bao, Yurong; Dong, Wei; Lu, Xudong; Duan, Huilong

    2014-10-01

    Compliance checking for clinical pathways (CPs) is getting increasing attention in health-care organizations due to stricter requirements for cost control and treatment excellence. Many compliance measures have been proposed for treatment behavior inspection in CPs. However, most of them look at aggregated data seen from an external perspective, e.g. length of stay, cost, infection rate, etc., which may provide only a posterior impression of the overall conformance with the established CPs such that in-depth and in near real time checking on the compliance of the essential/critical treatment behaviors of CPs is limited. To provide clinicians real time insights into violations of the established CP specification and support online compliance checking, this article presents a semantic rule-based CP compliance checking system. In detail, we construct a CP ontology (CPO) model to provide a formal grounding of CP compliance checking. Using the proposed CPO, domain treatment constraints are modeled into Semantic Web Rule Language (SWRL) rules to specify the underlying treatment behaviors and their quantified temporal structure in a CP. The established SWRL rules are integrated with the CP workflow such that a series of applicable compliance checking and evaluation can be reminded and recommended during the pathway execution. The proposed approach can, therefore, provides a comprehensive compliance checking service as a paralleling activity to the patient treatment journey of a CP rather than an afterthought. The proposed approach is illustrated with a case study on the unstable angina clinical pathway implemented in the Cardiology Department of a Chinese hospital. The results demonstrate that the approach, as a feasible solution to provide near real time conformance checking of CPs, not only enables clinicians to uncover non-compliant treatment behaviors, but also empowers clinicians with the capability to make informed decisions when dealing with treatment compliance

  16. Generic Architecture for Mobile Check System

    OpenAIRE

    KARIMA MAAZOUZ; HABIB.BENLAHMER; NACEUR.ACHTAICH

    2013-01-01

    the explosion of the market of Smartphone has rapidly changed the way of m-commerce transactions, especially the m-payment systems which are knowing a wide acceptance due to their diversity and the new mobile technologies. In this work we have introduced the system m-check as a mobile payment system, we have presented a generic architecture of the system and the different protocols for the implementation of the system m-check

  17. Generic Architecture for Mobile Check System

    Directory of Open Access Journals (Sweden)

    KARIMA MAAZOUZ

    2013-11-01

    Full Text Available the explosion of the market of Smartphone has rapidly changed the way of m-commerce transactions, especially the m-payment systems which are knowing a wide acceptance due to their diversity and the new mobile technologies. In this work we have introduced the system m-check as a mobile payment system, we have presented a generic architecture of the system and the different protocols for the implementation of the system m-check

  18. 31 CFR 235.4 - Check Forgery Insurance Fund.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Check Forgery Insurance Fund. 235.4... SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE ISSUANCE OF SETTLEMENT CHECKS FOR FORGED CHECKS DRAWN ON DESIGNATED DEPOSITARIES § 235.4 Check Forgery Insurance Fund. The Check Forgery...

  19. Semantic rule-checking for regulation compliance checking: an overview of strategies and approaches

    OpenAIRE

    Pauwels, Pieter; Zhang, Sijie

    2015-01-01

    As more and more architectural design and construction data is represented in the Resource Description Framework (RDF) data model, it makes sense to take advantage of the underlying logical basis of RDF and realise a semantic rule-checking process as it is currently not available in architectural design and construction industry. Such a semantic rule-checking process would be of considerable value to regulation compliance checking procedures, because the additional logical basis would (1) all...

  20. MPST Software: grl_pef_check

    Science.gov (United States)

    Call, Jared A.; Kwok, John H.; Fisher, Forest W.

    2013-01-01

    This innovation is a tool used to verify and validate spacecraft sequences at the predicted events file (PEF) level for the GRAIL (Gravity Recovery and Interior Laboratory, see http://www.nasa. gov/mission_pages/grail/main/index. html) mission as part of the Multi-Mission Planning and Sequencing Team (MPST) operations process to reduce the possibility for errors. This tool is used to catch any sequence related errors or issues immediately after the seqgen modeling to streamline downstream processes. This script verifies and validates the seqgen modeling for the GRAIL MPST process. A PEF is provided as input, and dozens of checks are performed on it to verify and validate the command products including command content, command ordering, flight-rule violations, modeling boundary consistency, resource limits, and ground commanding consistency. By performing as many checks as early in the process as possible, grl_pef_check streamlines the MPST task of generating GRAIL command and modeled products on an aggressive schedule. By enumerating each check being performed, and clearly stating the criteria and assumptions made at each step, grl_pef_check can be used as a manual checklist as well as an automated tool. This helper script was written with a focus on enabling the user with the information they need in order to evaluate a sequence quickly and efficiently, while still keeping them informed and active in the overall sequencing process. grl_pef_check verifies and validates the modeling and sequence content prior to investing any more effort into the build. There are dozens of various items in the modeling run that need to be checked, which is a time-consuming and errorprone task. Currently, no software exists that provides this functionality. Compared to a manual process, this script reduces human error and saves considerable man-hours by automating and streamlining the mission planning and sequencing task for the GRAIL mission.

  1. Recent improvements in check valve monitoring methods

    International Nuclear Information System (INIS)

    In support of the NRC Nuclear Plant Aging Research (NPAR) program, ORNL has carried out an evaluation of three check valve monitoring methods: acoustic emission, ultrasonic inspection, and magnetic flux signature analysis (MFSA). This work has focused on determining the capabilities of each method to provide diagnostic information useful in determining check valve aging and service wear effects (degradation) and undesirable operating modes. In addition, as part of the ORNL Advanced Diagnostic Engineering Research and Development Center (ADEC), two noval nonintrusive monitoring methods were developed (external ac- and dc-magnetic monitoring) that provide several improvements over the other methods. None of the examined methods could, by themselves, monitor the instantaneous position and motion of check valve internals and valve leakage; however, the combination of acoustic emission monitoring with one of the other methods provides the means to determine vital check valve operational information. This paper describes the benefits and limitations associated with each method and includes recent laboratory and field test data to illustrate the capabilities of these methods to detect simulated check valve degradation. 3 refs., 22 figs., 4 tabs

  2. A PSL Bounded Model Checking Method

    Institute of Scientific and Technical Information of China (English)

    YU Lei; ZHAO Zongtao

    2012-01-01

    SAT-based bounded model checking (BMC) is introduced as an important complementary technique to OBDD-based symbolic model checking, and is an efficient verification method for parallel and reactive systems. However, until now the properties verified by bounded model checking are very finite. Temporal logic PSL is a property specification language (IEEE-1850) describing parallel systems and is divided into two parts, i.e. the linear time logic FL and the branch time logic OBE. In this paper, the specification checked by BMC is extended to PSL and its algorithm is also proposed. Firstly, define the bounded semantics of PSL, and then reduce the bounded semantics into SAT by translating PSL specification formula and the state transition relation of the system to the propositional formula A and B, respectively. Finally, verify the satisfiability of the conjunction propositional formula of A and B. The algorithm results in the translation of the existential model checking of the temporal logic PSL into the satisfiability problem of propositional formula. An example of a queue controlling circuit is used to interpret detailedly the executing procedure of the algorithm.

  3. Monoclonal antibodies

    International Nuclear Information System (INIS)

    Monoclonal antibodies (MAbs) are antibodies having single specificity for a given antigen site (epitope). The development of hybridoma technology and the relative ease by which MAbs can be prepared has revolutionized many aspects of serological applications in diagnosis and differentiation of disease producing agents. The property of monospecificity offers advantages in diagnostic applications over polyclonal sera in that tests can be defined exactly with regard to the antigen detected and the affinity of reaction between the given antigenic site and the monoclonal reagent. In addition, MAbs offer better possibilities for test standardization, because the same reagent can be used in different laboratories. Such an MAb can be supplied by a central laboratory or 'grown' from hybridoma cells, ensuring that the resultant product is identical from laboratory to laboratory and that the part of the test involving the MAb reaction is the same. The methodologies for inoculation regimes, mice, cloning methods, selection of fusion partners, etc., have been validated extensively in developed country laboratories. The decision to establish a MAb production facility must be examined on a strict cost-benefit basis, since it is still expensive to produce a product. There are many MAbs available that should be sought to allow exploitation in developing tests. If a production facility is envisaged, it should produce reagents for national needs, i.e. there should be a clear problem oriented approach whereby exact needs are defined. In the field of veterinary applications, MAbs are the central reagent in many immunoassays based on the enzyme linked immunosorbent assay (ELISA). The development of specific tests for diagnosing diseases is dominated by MAbs and has been fuelled by a strong research base, mainly in developed countries allied to developing countries through the study of related diseases. Thus, there are very many assays dependent on MAbs, some of which form the basis of

  4. Check Point任命新总裁

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    近日,互联网安全解决方案供应商Check Point软件技术有限公司宣布,Amnon Bar—Lev晋升为公司总裁。Bar--Lev将继续掌管公司面向客户的工作,包括销售、市场营销、业务发展、技术服务和合作伙伴计划。Bar—Lev于2005年加入Check Point,担任技术服务副总裁,并于2006年开始领导全球市场运营。在此期间,Check Point营业额增长了1倍多,达到约12亿美元。

  5. Glovebox pressure relief and check valve

    Energy Technology Data Exchange (ETDEWEB)

    Blaedel, K.L.

    1986-03-17

    This device is a combined pressure relief valve and check valve providing overpressure protection and preventing back flow into an inert atmosphere enclosure. The pressure relief is embodied by a submerged vent line in a mercury reservior, the releif pressure being a function of the submerged depth. The pressure relief can be vented into an exhaust system and the relieving pressure is only slightly influenced by the varying pressure in the exhaust system. The check valve is embodied by a ball which floats on the mercury column and contacts a seat whenever vacuum exists within the glovebox enclosure. Alternatively, the check valve is embodied by a vertical column of mercury, the maximum back pressure being a function of the height of the column of mercury.

  6. HCH for Checking Containment of XPath Fragment

    Institute of Scientific and Technical Information of China (English)

    Jian-Hua Feng; Yu-Guo Liao; Yong Zhang

    2007-01-01

    XPath is ubiquitous in XML applications for navigating XML trees and selecting a set of element nodes. In XPath query processing, one of the most important issues is how to efficiently check containment relationship between two XPath expressions. To get out of the intricacy and complexity caused by numerous XPath features, we investigate this issue on a frequently used fragment of XPath expressions that consists of node tests, the child axis (/), the descendant axis (//), branches ([]) and label wildcards (*). Prior work has shown that homomorphism technology can be used for containment checking. However, homomorphism is the sufficient but not necessary condition for containment. For special classes of this fragment, the homomorphism algorithm returns false negatives. To address this problem, this paper proposes two containment techniques, conditioned homomorphism and hidden conditioned homomorphism, and then presents sound algorithms for checking containment. Experimental results confirm the practicability and efficiency of the proposed algorithms.

  7. Quality checking of radioactive and hazardous waste

    International Nuclear Information System (INIS)

    This report describes the work of the HMIP Waste Quality Checking Laboratory (WQCL) for the period September 1989 -August 1991. The WQCL has conducted research and development of procedures for the receipt, sampling and analysis of low level solid radioactive waste (LLW), intermediate level radioactive waste (ILW) and hazardous chemical waste (HW). Operational facilities have been commissioned for quality checking both LLW and HW. Waste quality checking has been completed on LLW packages seized from the UK waste disposal route by HMIP Inspectors. Packages have ranged in size from the 200 litre steel drum to half-height ISO freight container. Development work was continued on methods of sample extraction and radio-chemical analysis for cement encapsulated ILW in the form of magnox, graphite and stainless steel. This work was undertaken on non-radioactive simulants. (author)

  8. Checking Timed Automata for Linear Duration Properties

    Institute of Scientific and Technical Information of China (English)

    赵建华

    2000-01-01

    It is proved in this paper that checking a timed automaton M with respect to a linear duration property D can be done by investigating only the integral timed states of M. An equivalence relation is introduced in this paper to divide the infinite number of integral timed states into finite number of equivalence classes. Based on this, a method is proposed for checking whether M satisfies D. In some cases, the number of equivalence classes is too large for a computer to manipulate. A technique for reducing the search-space for checking linear duration property is also described. This technique is more suitable for the case in this paper than those in the literature because most of those techniques are designed for reachability analysis.

  9. Constraint LTL Satisfiability Checking without Automata

    CERN Document Server

    Bersani, Marcello M; Morzenti, Angelo; Pradella, Matteo; Rossi, Matteo; Pietro, Pierluigi San

    2012-01-01

    This paper introduces a novel technique to decide the satisfiability of formulae written in the language of Linear Temporal Logic with Both future and past operators and atomic formulae belonging to constraint system D (CLTLB(D) for short). The technique is based on the concept of bounded satisfiability, and hinges on an encoding of CLTLB(D) formulae into QF-EUD, the theory of quantifier-free equality and uninterpreted functions combined with D. Similarly to standard LTL, where bounded model-checking and SAT-solvers can be used as an alternative to automata-theoretic approaches to model-checking, our approach allows users to solve the satisfiability problem for CLTLB(D) formulae through SMT-solving techniques, rather than by checking the emptiness of the language of a suitable automaton A{\\phi}. The technique is effective, and it has been implemented in our Zot formal verification tool.

  10. A Metric Encoding for Bounded Model Checking

    Science.gov (United States)

    Pradella, Matteo; Morzenti, Angelo; San Pietro, Pierluigi

    In Bounded Model Checking, both the system model and the checked property are translated into a Boolean formula to be analyzed by a SAT-solver. We introduce a new encoding technique which is particularly optimized for managing quantitative future and past metric temporal operators, typically found in properties of hard real time systems. The encoding is simple and intuitive in principle, but it is made more complex by the presence, typical of the Bounded Model Checking technique, of backward and forward loops used to represent an ultimately periodic infinite domain by a finite structure. We report and comment on the new encoding technique and on an extensive set of experiments carried out to assess its feasibility and effectiveness.

  11. Graded CTL Model Checking for Test Generation

    CERN Document Server

    Napoli, Margherita

    2011-01-01

    Recently there has been a great attention from the scientific community towards the use of the model-checking technique as a tool for test generation in the simulation field. This paper aims to provide a useful mean to get more insights along these lines. By applying recent results in the field of graded temporal logics, we present a new efficient model-checking algorithm for Hierarchical Finite State Machines (HSM), a well established symbolism long and widely used for representing hierarchical models of discrete systems. Performing model-checking against specifications expressed using graded temporal logics has the peculiarity of returning more counterexamples within a unique run. We think that this can greatly improve the efficacy of automatically getting test cases. In particular we verify two different models of HSM against branching time temporal properties.

  12. Glovebox pressure relief and check valve

    International Nuclear Information System (INIS)

    This device is a combined pressure relief valve and check valve providing overpressure protection and preventing back flow into an inert atmosphere enclosure. The pressure relief is embodied by a submerged vent line in a mercury reservior, the releif pressure being a function of the submerged depth. The pressure relief can be vented into an exhaust system and the relieving pressure is only slightly influenced by the varying pressure in the exhaust system. The check valve is embodied by a ball which floats on the mercury column and contacts a seat whenever vacuum exists within the glovebox enclosure. Alternatively, the check valve is embodied by a vertical column of mercury, the maximum back pressure being a function of the height of the column of mercury

  13. Gate-Check System for Outotec Company

    OpenAIRE

    Zajac, Lukas; Bartusek, Petr

    2014-01-01

    The main purpose of the thesis was to create the interactive, electronic web application Gate-Check for Outotec Company, which replaced the old system based on MS Excel document. Another purpose was gaining new skills and experiences in communication with the company, in which the team acted as a Supply Company. The created web application (Gate-Check System) should be compatible with any device with integrated web browser with support HTML5, JavaScript and CSS3 and active internet connect...

  14. Engineering Abstractions in Model Checking and Testing

    DEFF Research Database (Denmark)

    Achenbach, Michael; Ostermann, Klaus

    2009-01-01

    Abstractions are used in model checking to tackle problems like state space explosion or modeling of IO. The application of these abstractions in real software development processes, however, lacks engineering support. This is one reason why model checking is not widely used in practice yet and...... testing is still state of the art in falsification. We show how user-defined abstractions can be integrated into a Java PathFinder setting with tools like AspectJ or Javassist and discuss implications of remaining weaknesses of these tools. We believe that a principled engineering approach to designing...

  15. A Systematic Review of the Empirical Support for Check-in Check-Out

    Science.gov (United States)

    Wolfe, Katie; Pyle, Daniel; Charlton, Cade T.; Sabey, Christian V.; Lund, Emily M.; Ross, Scott W.

    2016-01-01

    Tier 2 interventions play an important role within the Positive Behavioral Interventions and Supports framework, bridging the gap between schoolwide Tier 1 interventions and individualized Tier 3 supports. Check-in Check-out (CICO) is a promising Tier 2 intervention for addressing mild problem behavior and potentially preventing the need for more…

  16. Function-Based Modification of Check-In/Check-Out to Influence Escape-Maintained Behavior

    Science.gov (United States)

    Kilgus, Stephen P.; Fallon, Lindsay M.; Feinberg, Adam B.

    2016-01-01

    Prior research has suggested Check-In/Check-Out (CICO) effectiveness is linked to the function of problem behavior. Though effective for students whose misbehavior occurs to gain attention, findings are equivocal for behavior that occurs to escape academic tasks. The purpose of this study was to therefore evaluate a modification to CICO, wherein…

  17. Monoclonal antibodies.

    Science.gov (United States)

    2009-01-01

    The ability to produce and exploit monoclonal antibodies (mAbs) has revolutionized many areas of biological sciences. The unique property of an mAb is that it is a single species of immunoglobulin (IG) molecule. This means that the specificity of the interaction of the paratopes on the IG, with the epitopes on an antigenic target, is the same on every molecule. This property can be used to great benefit in immunoassays to provide tests of defined specificity and sensitivity, which improve the possibilities of standardization. The performance of assays can often be determined relating the actual weight of antibody (hence the number of molecules) to the activity. Often the production of an mAb against a specific epitope is the only way that biological entities can be differentiated. This chapter outlines the areas involving the development of assays based on mAbs. The problems involved address include the physical aspects of mAbs and how they may affect assay design and also the implications of results based on monospecific reagents. Often these are not fully understood, leading to assays that are less than satisfactory, which does not justify the relatively high cost of preparing and screening of mAbs. There are many textbooks and reviews dealing with the preparation of mAbs, the principles involved, and various purification and manipulative methods for the preparation of fragments and conjugation. There has been little general information attempting to summarize the best approaches to assay design using mAbs. Much time can be wasted through bad planning, and this is particularly relevant to mAbs. A proper understanding of some basic principles is essential. It is beyond the scope of this chapter to discuss all aspects, but major areas are highlighted. PMID:19219589

  18. Anchor Stress Checking of Security Injection Tank

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The intention of the calculating is to check the anchor stresses of the security injection tank to know whether the stress is satisfied the code requirements on the basis of all the reaction forces gained in the static, seismic and thermal stress results.

  19. Regulatory Conformance Checking: Logic and Logical Form

    Science.gov (United States)

    Dinesh, Nikhil

    2010-01-01

    We consider the problem of checking whether an organization conforms to a body of regulation. Conformance is studied in a runtime verification setting. The regulation is translated to a logic, from which we synthesize monitors. The monitors are evaluated as the state of an organization evolves over time, raising an alarm if a violation is…

  20. Statistical Model Checking for Biological Systems

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Legay, Axel;

    2014-01-01

    Statistical Model Checking (SMC) is a highly scalable simulation-based verification approach for testing and estimating the probability that a stochastic system satisfies a given linear temporal property. The technique has been applied to (discrete and continuous time) Markov chains, stochastic...

  1. A Method for Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Pedersen, Thomas; Le Guilly, Thibaut; Ravn, Anders Peter; Skou, Arne Joachim

    This paper presents a method to check for feature interactions in a system assembled from independently developed concurrent processes as found in many reactive systems. The method combines and refines existing definitions and adds a set of activities. The activities describe how to populate the ...

  2. Using chemical organization theory for model checking

    OpenAIRE

    Kaleta, Christoph; Richter, Stephan; Dittrich, Peter

    2009-01-01

    Motivation: The increasing number and complexity of biomodels makes automatic procedures for checking the models' properties and quality necessary. Approaches like elementary mode analysis, flux balance analysis, deficiency analysis and chemical organization theory (OT) require only the stoichiometric structure of the reaction network for derivation of valuable information. In formalisms like Systems Biology Markup Language (SBML), however, information about the stoichiometric coefficients re...

  3. Efficient CSL Model Checking Using Stratification

    DEFF Research Database (Denmark)

    Zhang, Lijun; Jansen, David N.; Nielson, Flemming; Hermanns, Holger

    2012-01-01

    For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996 [ 1, 2]. Their proof can be turned into an approximation algorithm with worse than...

  4. Automata-Based CSL Model Checking

    DEFF Research Database (Denmark)

    Zhang, Lijun; Jansen, David N.; Nielson, Flemming; Hermanns, Holger

    For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996. The presented decision procedure, however, has exponential complexity. In this paper, we...

  5. Type checking with open type functions

    DEFF Research Database (Denmark)

    Schrijvers, Tom; Jones, Simon Peyton; Chakravarty, Manual; Sulzmann, Martin

    We report on an extension of Haskell with open type-level functions and equality constraints that unifies earlier work on GADTs, functional dependencies, and associated types. The contribution of the paper is that we identify and characterise the key technical challenge of entailment checking; and...

  6. Availability of a Renewable, Checked System

    DEFF Research Database (Denmark)

    Platz, O.

    1976-01-01

    Recurrent expressions are given for point and interval unavailability of a renewable system subjected to periodic checking/repair. The expressions are generalizations of the basic relations in the theory of discrete renewal processes. The asymptotic limits for long times follow simply from a...

  7. The common agricultural policy health check

    OpenAIRE

    Erjavec, Emil; Lovec, Marko

    2016-01-01

    In 2008, the ministers of agriculture of European Union member states made a political agreement on the Common Agricultural Policy reform, also known as the Health Check. The reform coincided with three things: the ongoing Doha round of the World Trade Organization negotiations

  8. 40 CFR 86.327-79 - Quench checks; NOX analyzer.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Quench checks; NOX analyzer. 86.327-79... Quench checks; NOX analyzer. (a) Perform the reaction chamber quench check for each model of high vacuum... capillary, and if used, dilution capillary. (c) Quench check as follows: (1) Calibrate the NOX analyzer...

  9. Quality control checks and balances in ENSDF

    International Nuclear Information System (INIS)

    The Evaluated Nuclear Structure Data File (ENSDF) is the repository of data evaluated by the members of the International Nuclear Structure and Decay Data Network. This network includes evaluators at 15 data centers in 10 countries and operates under the auspices of the International Atomic Energy Agency. The main output of the data from this file is the journal Nuclear Data Sheets, widely used by the nuclear structure research community; however, specialized output from this file is also prepared for applied users in the fields of medical practice and research, health physics, industry, nuclear power, and environmental protection. This paper describes the various means each evaluator has access to including format-checking programs and programs for checking/evaluating physical quantities and calculations

  10. Advanced techniques for efficient data integrity checking

    DEFF Research Database (Denmark)

    Martinenghi, Davide

    Integrity constraint checking, understood as the verification of data correctness and well-formedness conditions that must be satisfied in any state of a database, is not fully supported by current database technology. In a typical scenario, a database is required to comply with given semantic cr...... contexts, such as recursive databases, concurrent database systems, data integration systems and XML document collections, and provide a performance evaluation of the proposed model.......Integrity constraint checking, understood as the verification of data correctness and well-formedness conditions that must be satisfied in any state of a database, is not fully supported by current database technology. In a typical scenario, a database is required to comply with given semantic...... criteria (the integrity constraints) and to maintain the compliance each time data are updated. Since the introduction of the SQL2 standard, the SQL language started supporting assertions, which allow one to define general data consistency requirements expressing arbitrarily complex “business rules” that...

  11. CHECK-IN/CHECK-OUT: A SYSTEMATIC EVALUATION AND COMPONENT ANALYSIS

    OpenAIRE

    Campbell, Amy; Anderson, Cynthia M.

    2011-01-01

    Tier 2 interventions are implemented similarly across students and thus serve as an efficient and cost-effective method of behavior support in school settings. Check-in/check-out is a Tier 2 intervention with documented effectiveness (e.g., Hawken & Horner, 2003; Todd, Campbell, Meyer, & Horner, 2008). Key features of the intervention include brief morning and afternoon meetings with the intervention coordinator, use of a point card on which the teacher monitors student behavior, and teacher ...

  12. Quality of histone modification antibodies undermines chromatin biology research [version 1; referees: 1 approved, 2 approved with reservations

    OpenAIRE

    Goran Kungulovski; Albert Jeltsch

    2015-01-01

    Histone post-translational modification (PTM) antibodies are essential research reagents in chromatin biology. However, they suffer from variable properties and insufficient documentation of quality. Antibody manufacturers and vendors should provide detailed lot-specific documentation of quality, rendering further quality checks by end-customers unnecessary. A shift from polyclonal antibodies towards sustainable reagents like monoclonal or recombinant antibodies or histone binding domains wou...

  13. Speed checks on the CERN site

    CERN Multimedia

    2007-01-01

    In view of the significant number of speeding incidents that have been reported, CERN will shortly start to carry out speed checks on the site. The radar used for this purpose will show drivers the speed measured. The disciplinary measures taken against those exceeding the authorised limit (generally 50 k.p.h.) will include a ban from driving on the site for a minimum of one month. Maximilian Metzger
Secretary-General

  14. Checking C Pointer Programs for Memory Safety

    OpenAIRE

    Moy, Yannick

    2007-01-01

    We propose an original approach for checking memory safety of C pointer programs possibly including pointer arithmetic and sharing (but no casts, structures, double indirection or memory deallocation). This involves first identifying aliasing and strings, which we do in a local setting rather than through a global analysis as it is done usually. Our separation analysis in particular is a totally new treatment of non-aliasing. We present for the first time two abstract lattices to deal with lo...

  15. Statistical Model Checking for Stochastic Hybrid Systems

    DEFF Research Database (Denmark)

    David, Alexandre; Du, Dehui; Larsen, Kim Guldstrand; Legay, Axel; Mikučionis, Marius; Poulsen, Danny Bøgsted; Sedwards, Sean

    This paper presents novel extensions and applications of the UPPAAL-SMC model checker. The extensions allow for statistical model checking of stochastic hybrid systems. We show how our race-based stochastic semantics extends to networks of hybrid systems, and indicate the integration technique...... applied for implementing this semantics in the UPPAAL-SMC simulation engine. We report on two applications of the resulting tool-set coming from systems biology and energy aware buildings....

  16. From model checking to model measuring

    OpenAIRE

    Henzinger, Thomas A.; Otop, Jan

    2013-01-01

    We define the model-measuring problem: given a model $M$ and specification~$\\varphi$, what is the maximal distance $\\rho$ such that all models $M'$ within distance $\\rho$ from $M$ satisfy (or violate)~$\\varphi$. The model measuring problem presupposes a distance function on models. We concentrate on automatic distance functions, which are defined by weighted automata. The model-measuring problem subsumes several generalizations of the classical model-checking problem, in particular, qu...

  17. The Activity Check of Brachytherapy Isotope

    International Nuclear Information System (INIS)

    An isotope Ir-192, which is used in brachytherapy depends on import in whole quantities. There are a few ways for its activity. measurement using Welltype chamber or the way to rely on authentic decay table of manufacturer. In-air dosimetry using Farmer Chamber, etc. In this paper, let me introduce the way using Farmer chamber which is easier and simple. With the Farmer chamber and source calibration jig, take a measurement the activity of an isotope Ir-192 and compare the value with the value from decay table of manufacturer and check the activity of source. The result of measurement, compared the value from decay table, by ±2.1. (which belongs to recommendable value for AAPM ±5% as difference of error range). It is possible to use on clinical medicine. With the increase in use of brachytherapy, the increase of import is essential. And an accurate activity check of source is compulsory. For the activity check of source, it was possible to use Farmer chamber and source calibration jig without additional purchase of Well type chamber.

  18. A rigorous approach to self-checking programming

    Science.gov (United States)

    Hua, Kien A.; Abraham, Jacob A.

    1986-01-01

    Self-checking programming is shown to be an effective concurrent error detection technique. The reliability of a self-checking program however relies on the quality of its assertion statements. A self-checking program written without formal guidelines could provide a poor coverage of the errors. A constructive technique for self-checking programming is presented. A Structured Program Design Language (SPDL) suitable for self-checking software development is defined. A set of formal rules, was also developed, that allows the transfromation of SPDL designs into self-checking designs to be done in a systematic manner.

  19. Antibodies and Selection of Monoclonal Antibodies.

    Science.gov (United States)

    Hanack, Katja; Messerschmidt, Katrin; Listek, Martin

    2016-01-01

    Monoclonal antibodies are universal binding molecules with a high specificity for their target and are indispensable tools in research, diagnostics and therapy. The biotechnological generation of monoclonal antibodies was enabled by the hybridoma technology published in 1975 by Köhler and Milstein. Today monoclonal antibodies are used in a variety of applications as flow cytometry, magnetic cell sorting, immunoassays or therapeutic approaches. First step of the generation process is the immunization of the organism with appropriate antigen. After a positive immune response the spleen cells are isolated and fused with myeloma cells in order to generate stable, long-living antibody-producing cell lines - hybridoma cells. In the subsequent identification step the culture supernatants of all hybridoma cells are screened weekly for the production of the antibody of interest. Hybridoma cells producing the antibody of interest are cloned by limited dilution till a monoclonal hybridoma is found. This is a very time-consuming and laborious process and therefore different selection strategies were developed since 1975 in order to facilitate the generation of monoclonal antibodies. Apart from common automation of pipetting processes and ELISA testing there are some promising approaches to select the right monoclonal antibody very early in the process to reduce time and effort of the generation. In this chapter different selection strategies for antibody-producing hybridoma cells are presented and analysed regarding to their benefits compared to conventional limited dilution technology. PMID:27236550

  20. SAT-Based Model Checking without Unrolling

    Science.gov (United States)

    Bradley, Aaron R.

    A new form of SAT-based symbolic model checking is described. Instead of unrolling the transition relation, it incrementally generates clauses that are inductive relative to (and augment) stepwise approximate reachability information. In this way, the algorithm gradually refines the property, eventually producing either an inductive strengthening of the property or a counterexample trace. Our experimental studies show that induction is a powerful tool for generalizing the unreachability of given error states: it can refine away many states at once, and it is effective at focusing the proof search on aspects of the transition system relevant to the property. Furthermore, the incremental structure of the algorithm lends itself to a parallel implementation.

  1. Checking MSC Specifications for Timing Inconsistency

    Institute of Scientific and Technical Information of China (English)

    LI Xuandong(李宣东); TAN Wenkai(谭文凯); ZHENG Guoliang(郑国梁)

    2002-01-01

    Message sequence chart (MSC) is a graphical and textual language for the description and specification of the interactions between system components. MSC specifica tions allow convenient expression of multiple scenarios, and offer an intuitive and visual way of describing design requirements. Like any other aspect of the specification and design process, MSCs are amenable to errors, and their analysis is important. In this paper, the verification problem of MSC specification for timing inconsistency is studied, which means that no execu tion scenario described by an MSC specification is timing consistent. An algorithm is developed to check MSC specifications for timing inconsistency.

  2. Political and judicial checks on corruption

    DEFF Research Database (Denmark)

    Alt, James E.; Lassen, David Dreyer

    2008-01-01

    This paper investigates the effects of checks and balances on corruption. Within a presidential system, effective separation of powers is achieved under a divided government, with the executive and legislative branches being controlled by different political parties. When government is unified, no...... effective separation exists even within a presidential system, but, we argue, can be partially restored by having an accountable judiciary. Our empirical findings show that a divided government and elected, rather than appointed, state supreme court judges are associated with lower corruption and...

  3. Quantum anonymous voting with anonymity check

    International Nuclear Information System (INIS)

    We propose a new protocol for quantum anonymous voting having serious advantages over the existing protocols: it protects both the voters from a curious tallyman and all the participants from a dishonest voter in unconditional way. The central idea of the protocol is that the ballots are given back to the voters after the voting process, which gives a possibility for two voters to check the anonymity of the vote counting process by preparing a special entangled state of two ballots. Any attempt of cheating from the side of the tallyman results in destroying the entanglement, which can be detected by the voters.

  4. Applying GPS to check horizontal control quality

    OpenAIRE

    Jakub Vincent; Weiss Gabriel; Sabová Jana

    2004-01-01

    GPS technologies can also be used for check quality in available horizontal point set with coordinates CJ of the frame S-JTSK. When survey and setting-out tasks should be performed in certain area, one can found in it allways some points of the fundamental and detail state controls. To use these points for some actual aims, it is necessary to investigate their compatibility (among the point mark positions and the point coordinate of control points). This can be done using GPS surveying that m...

  5. Distributed Parametric and Statistical Model Checking

    Directory of Open Access Journals (Sweden)

    Peter Bulychev

    2011-10-01

    Full Text Available Statistical Model Checking (SMC is a trade-off between testing and formal verification. The core idea of the approach is to conduct some simulations of the system and verify if they satisfy some given property. In this paper we show that SMC is easily parallelizable on a master/slaves architecture by introducing a series of algorithms that scale almost linearly with respect to the number of slave computers. Our approach has been implemented in the UPPAAL SMC toolset and applied on non-trivial case studies.

  6. Infeasibility of Quantum Cryptography Without Eavesdropping Check

    Science.gov (United States)

    Yang, Wei; Huang, Liusheng; Song, Fang; Wang, Qiyan

    Secure key distribution is impossible in pure classical environment. Unconditional secure key distribution is available when quantum means are introduced, assisted by a classical communication channel. What is possible when a quantum key distribution scheme is without classical communication? We present a general model with this constraint and show that quantum key distribution without classical eavesdropping check is in principle impossible. For an adversary can always succeed in obtaining the secret key via a special case of man-in-the-middle attack, namely intercept-and-forward attack without any risk of being captured.

  7. A computer-checked verification of Milner's scheduler

    OpenAIRE

    Korver, H.; Springintveld, J.

    1993-01-01

    We present an equational verification of Milner's scheduler, which we checked by computer.To our knowledge this is the first time that the scheduler is proof-checked for a general number n of scheduled processes.

  8. Non intrusive check valve diagnostics at Bruce A

    International Nuclear Information System (INIS)

    Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

  9. Non intrusive check valve diagnostics at Bruce A

    Energy Technology Data Exchange (ETDEWEB)

    Marsch, S.P. [Ontario Hydro, Bruce Nuclear Generating Station A, Tiverton, ON (Canada)

    1997-07-01

    Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

  10. Buckling check tools for plate panel and column structures

    OpenAIRE

    Vuorela, Pia

    2014-01-01

    Buckling is, besides yielding, one of the major causes of failures in structures, and buckling checks are therefore an integral part of strength analyses. Checks can be performed either with methods requiring heavy numerical calculations or with equations based on rules and recommendations from a classification society. Numerical calculations are extremely time-consuming and commercial buckling check programs are expensive. There is therefore a need for buckling check tools based on the recom...

  11. Model Checking Is Static Analysis of Modal Logic

    DEFF Research Database (Denmark)

    Nielson, Flemming; Nielson, Hanne Riis

    2010-01-01

    it can give an exact characterisation of the semantics of formulae in a modal logic. This shows that model checking can be performed by means of state-of-the-art approaches to static analysis and allow us to conclude that the problems of model checking and static analysis are reducible to each other....... In terms of computational complexity we show that model checking by means of static analysis gives the same complexity bounds as are known for traditional approaches to model checking....

  12. Molecular double-check strategy for the identification and characterization of European Lyssaviruses

    DEFF Research Database (Denmark)

    Fischer, Melina; Freuling, Conrad M.; Müller, Thomas;

    2014-01-01

    The “gold standard” for post-mortem rabies diagnosis is the direct fluorescent antibody test (FAT). However, in the case of ante-mortem non-neural sample material or decomposed tissues, the FAT reaches its limit, and the use of molecular techniques can be advantageous. In this study, we developed......-systems for Rabies virus, European bat lyssavirus type 1 and 2 as well as Bokeloh bat lyssavirus. All assays were validated successfully with a comprehensive panel of lyssavirus positive samples, as well as negative material from various host species. This double-check strategy allows for both safe and...

  13. Model-Based Trace-Checking

    CERN Document Server

    Howard, Y; Gravell, A; Ferreira, C; Augusto, J C

    2011-01-01

    Trace analysis can be a useful way to discover problems in a program under test. Rather than writing a special purpose trace analysis tool, this paper proposes that traces can usefully be analysed by checking them against a formal model using a standard model-checker or else an animator for executable specifications. These techniques are illustrated using a Travel Agent case study implemented in J2EE. We added trace beans to this code that write trace information to a database. The traces are then extracted and converted into a form suitable for analysis by Spin, a popular model-checker, and Pro-B, a model-checker and animator for the B notation. This illustrates the technique, and also the fact that such a system can have a variety of models, in different notations, that capture different features. These experiments have demonstrated that model-based trace-checking is feasible. Future work is focussed on scaling up the approach to larger systems by increasing the level of automation.

  14. Model Checking over Paraconsistent Temporal Logic

    Institute of Scientific and Technical Information of China (English)

    CHEN Dong-huo; WANG Lin-zhang; CUI Jia-lin

    2008-01-01

    Classical logic cannot be used to effectively reason about concurrent systems with inconsistencies (inconsistencies often occur, especially in the early stage of the development, when large and complex concurrent systems are developed). In this paper, we propose the use of a guasi-classical temporal logic (QCTL) for supporting the verification of temporal properties of such systems even where the consistent model is not available. Our models are paraKripke structures ( extended standard Kripke structures), in which both a formula and its negation are satisfied in a same state, and properties to be verified are expressed by QCTL with paraKripke structures semantics. We introduce a novel notion of paraKripke models, which grasps the paraconsistent character of the entailment relation of QCTL. Furthermore, we explore the methodology of model checking over QCTL, and describe the detailed algorithm of implementing QCTL model checker. In the sequel, a simple example is presented, showing how to exploit the proposed model checking technique to verify the temporal properties of inconsistent concurrent systems.

  15. Improved Message Authentication and Confidentiality Checking

    International Nuclear Information System (INIS)

    The most confusing areas of the secured network communications are the message authentication and confidentiality checking. The attacks and the counter measures have become so convoluted that the users in this area begin to account for all contingencies. Two session-key generation techniques are used here to generate two separate session keys K1 and K2; and both the sender and the reveiver share these keys for higher degree of authentication and confidentiality. For this, the message is first encrypted by the key K1, and then the intermediary message authenticatin code (MAC) is generated by encrypting the encrypted message using the key K2. Then, the encrypted message and the intermediary MAC is again encrypted by using the K2 and concatenated with the encrypted message and sent to the destination. At the receiving end, first, the received ciphertext is encrypted by using key K2 and compared to the received MAC. The received ciphertext again is decrypted by the key K2 and compared with the first decrypted MAC twice by the key K2. The plaintext is obtained by decrypting the received ciphertext first by K2 and then by K1, using the corresponding decryption techniques respectively. The encryption techniques with key K2 provides the authentication and with key K1 provides the confidentiality checking of the transmitted message. The developed technique can be applied to both academic and commercial applications in online or offline electronic transactions for security.(authors)

  16. Testing Intelligently Includes Double-Checking Wechsler IQ Scores

    Science.gov (United States)

    Kuentzel, Jeffrey G.; Hetterscheidt, Lesley A.; Barnett, Douglas

    2011-01-01

    The rigors of standardized testing make for numerous opportunities for examiner error, including simple computational mistakes in scoring. Although experts recommend that test scoring be double-checked, the extent to which independent double-checking would reduce scoring errors is not known. A double-checking procedure was established at a…

  17. 32 CFR 809a.1 - Random installation entry point checks.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Random installation entry point checks. 809a.1... Entry Policy § 809a.1 Random installation entry point checks. The installation commander determines when, where, and how to implement random checks of vehicles or pedestrians. The commander conducts...

  18. Antiphospholipid Antibody Syndrome

    Science.gov (United States)

    ... page from the NHLBI on Twitter. What Is Antiphospholipid Antibody Syndrome? Antiphospholipid (AN-te-fos-fo-LIP-id) antibody ... weeks or months. This condition is called catastrophic antiphospholipid syndrome (CAPS). People who have APS also are at ...

  19. The antibody mining toolbox

    OpenAIRE

    D'Angelo, Sara; Glanville, Jacob; Ferrara, Fortunato; Naranjo, Leslie; Gleasner, Cheryl D.; Shen, Xiaohong; Bradbury, Andrew RM; Kiss, Csaba

    2013-01-01

    In vitro selection has been an essential tool in the development of recombinant antibodies against various antigen targets. Deep sequencing has recently been gaining ground as an alternative and valuable method to analyze such antibody selections. The analysis provides a novel and extremely detailed view of selected antibody populations, and allows the identification of specific antibodies using only sequencing data, potentially eliminating the need for expensive and laborious low-throughput ...

  20. Improved Integrity Constraints Checking in Distributed Databases by Exploiting Local Checking

    Institute of Scientific and Technical Information of China (English)

    Ali A.Alwan; Hamidah Ibrahim; Nur Izura Udzir

    2009-01-01

    Most of the previous studies concerning checking the integrity constraints in distributed database derive simplified forms of the initial integrity constraints with the sufficiency property, since the sufficient test is known to be cheaper than the complete test and its initial integrity constraint as it involves less data to be transferred across the network and can always be evaluated at the target site (single site). Their studies are limited as they depend strictly on the assumption that an update operation will be executed at a site where the relation specified in the update operation is located, which is not always true. Hence, the sufficient test, which is proven to be local test by previous study, is no longer appropriate. This paper proposes an approach to checking integrity constraints in a distributed database by utilizing as much as possible the local information stored at the target site. The proposed approach derives support tests as an alternative to the existing complete and sufficient tests proposed by previous researchers with the intention to increase the number of local checking regardless the location of the submitted update operation. Several analyses have been performed to evaluate the proposed approach, and the results show that support tests can benefit the distributed database, where local constraint checking can be achieved.

  1. Check all SCHE Supply Purge Check Valves to Prevent Back Flow from SCHE into Helium Supply

    Energy Technology Data Exchange (ETDEWEB)

    MISKA, C.R.

    2000-10-23

    These valves are 1/2-inch check valves used to prevent SCHe backflow into the Helium System if pressure in the Helium System drops below the pressure of the control valve downstream of the SCHe supply bottles. (14 psig in trains A and B and 2 psig in trains C and D).

  2. Check all SCHe Supply Purge Check Valves to Prevent Back Flow from SCHe into Helium Supply

    International Nuclear Information System (INIS)

    These valves are 1/2-inch check valves used to prevent SCHe backflow into the Helium System if pressure in the Helium System drops below the pressure of the control valve downstream of the SCHe supply bottles. (14 psig in trains A and B and 2 psig in trains C and D)

  3. Heavy chain only antibodies

    DEFF Research Database (Denmark)

    Moghimi, Seyed Moein; Rahbarizadeh, Fatemeh; Ahmadvand, Davoud;

    2013-01-01

    Unlike conventional antibodies, heavy chain only antibodies derived from camel contain a single variable domain (VHH) and two constant domains (CH2 and CH3). Cloned and isolated VHHs possess unique properties that enable them to excel conventional therapeutic antibodies and their smaller antigen...

  4. Hepatitis A virus antibody

    International Nuclear Information System (INIS)

    A description is presented of a radioimmunoassay designed to prove the presence of the antibody against the hepatitis A virus (HA Ab, anti-Ha) using an Abbott HAVAB set. This proof as well as the proof of the antibody against the nucleus of the hepatitis B virus is based on competition between a normal antibody against hepatitis A virus and a 125I-labelled antibody for the binding sites of a specific antigen spread all over the surface of a tiny ball; this is then indirect proof of the antibody under investigation. The method is described of reading the results from the number of impulses per 60 seconds: the higher the titre of the antibody against the hepatitis A virus in the serum examined, the lower the activity of the specimen concerned. The rate is reported of incidence of the antibody against the hepatitis A virus in a total of 68 convalescents after hepatitis A; the antibody was found in 94.1%. The immunoglobulin made from the convalescents' plasma showed the presence of antibodies in dilutions as high as 1:250 000 while the comparable ratio for normal immunoglobulin Norga was only 1:2500. Differences are discussed in the time incidence of the antibodies against the hepatitis A virus, the antibodies against the surface antigen of hepatitis B, and the antibody against the nucleus of the hepatitis V virus. (author)

  5. The Mars Science Laboratory Organic Check Material

    Science.gov (United States)

    Conrad, Pamela G.; Eigenbrode, Jennifer L.; Von der Heydt, Max O.; Mogensen, Claus T.; Canham, John; Harpold, Dan N.; Johnson, Joel; Errigo, Therese; Glavin, Daniel P.; Mahaffy, Paul R.

    2012-09-01

    Mars Science Laboratory's Curiosity rover carries a set of five external verification standards in hermetically sealed containers that can be sampled as would be a Martian rock, by drilling and then portioning into the solid sample inlet of the Sample Analysis at Mars (SAM) suite. Each organic check material (OCM) canister contains a porous ceramic solid, which has been doped with a fluorinated hydrocarbon marker that can be detected by SAM. The purpose of the OCM is to serve as a verification tool for the organic cleanliness of those parts of the sample chain that cannot be cleaned other than by dilution, i.e., repeated sampling of Martian rock. SAM possesses internal calibrants for verification of both its performance and its internal cleanliness, and the OCM is not used for that purpose. Each OCM unit is designed for one use only, and the choice to do so will be made by the project science group (PSG).

  6. Improving Atm Security Check Using DNA Biometrics

    Directory of Open Access Journals (Sweden)

    Igwe, Agu Felix

    2015-06-01

    Full Text Available This paper exposes how DNA can be used to identify account owner of a particular bank.DNA samples were obtained from body fluid. Buccal swab was used for sample collection .Buccal cell collection involves wiping a small piece of filter paper or a cotton swab against the inside of armpit in order to collect shed epithelial cells. The swab was then air dried or could be pressed against a treated collection card in order to transfer epithelial cells for storage purposes. The stored samples were later amplified and separated .The data generated from the samples were stored and saved in the database so that if a customer comes to claim money, the system checks whether it matches with what is stored in the database ,if it matches with the one in the database, access is granted to the customer,.if it does not match with what is stored in the database ,access is denied from the customer

  7. Workflow Fault Tree Generation Through Model Checking

    DEFF Research Database (Denmark)

    Herbert, Luke Thomas; Sharp, Robin

    2014-01-01

    probabilistic structure of the system being modelled. From these calculations, a comprehensive fault tree is generated. Further, we show that annotating the model with rewards (data) allows the expected mean values of reward structures to be calculated at points of failure....... with probabilistic non-deterministic branching. We present an algorithm that allows for exhaustive generation of possible error states that could arise in execution of the model, where the generated error states allow for both fail-stop behaviour and continued system execution. We employ stochastic...... model checking to calculate the probabilities of reaching each non-error system state. Each generated error state is assigned a variable indicating its individual probability of occurrence. Our method can determine the probability of combined faults occurring, while accounting for the basic...

  8. Thermodynamic Pressure/Temperature Transducer Health Check

    Science.gov (United States)

    Immer, Christopher D. (Inventor); Eckhoff, Anthony (Inventor); Medelius, Pedro J. (Inventor); Deyoe, Richard T. (Inventor); Starr, Stanley O. (Inventor)

    2004-01-01

    A device and procedure for checking the health of a pressure transducer in situ is provided. The procedure includes measuring a fixed change in pressure above ambient pressure and a fixed change in pressure below ambient pressure. This is done by first sealing an enclosed volume around the transducer with a valve. A piston inside the sealed volume is increasing the pressure. A fixed pressure below ambient pressure is obtained by opening the valve, driving the piston The output of the pressure transducer is recorded for both the overpressuring and the underpressuring. By comparing this data with data taken during a preoperative calibration, the health of the transducer is determined from the linearity, the hysteresis, and the repeatability of its output. The further addition of a thermometer allows constant offset error in the transducer output to be determined.

  9. Static Checking of Interrupt-driven Software

    DEFF Research Database (Denmark)

    Brylow, Dennis; Damgaard, Niels; Palsberg, Jens

    2001-01-01

    Resource-constrained devices are becoming ubiquitous. Examples include cell phones, palm pilots, and digital thermostats. It can be difficult to fit required functionality into such a device without sacrificing the simplicity and clarity of the software. Increasingly complex embedded systems...... require extensive brute-force testing, making development and maintenance costly. This is particularly true for system components that are written in assembly language. Static checking has the potential of alleviating these problems, but until now there has been little tool support for programming at the...... assembly level. In this paper we present the design and implementation of a static checker for interrupt-driven Z86-based software with hard real-time requirements. For six commercial microcontrollers, our checker has produced upper bounds on interrupt latencies and stack sizes, as well as verified...

  10. Model Checking JAVA Programs Using Java Pathfinder

    Science.gov (United States)

    Havelund, Klaus; Pressburger, Thomas

    2000-01-01

    This paper describes a translator called JAVA PATHFINDER from JAVA to PROMELA, the "programming language" of the SPIN model checker. The purpose is to establish a framework for verification and debugging of JAVA programs based on model checking. This work should be seen in a broader attempt to make formal methods applicable "in the loop" of programming within NASA's areas such as space, aviation, and robotics. Our main goal is to create automated formal methods such that programmers themselves can apply these in their daily work (in the loop) without the need for specialists to manually reformulate a program into a different notation in order to analyze the program. This work is a continuation of an effort to formally verify, using SPIN, a multi-threaded operating system programmed in Lisp for the Deep-Space 1 spacecraft, and of previous work in applying existing model checkers and theorem provers to real applications.

  11. Conformant Planning via Symbolic Model Checking

    CERN Document Server

    Cimatti, A; 10.1613/jair.774

    2011-01-01

    We tackle the problem of planning in nondeterministic domains, by presenting a new approach to conformant planning. Conformant planning is the problem of finding a sequence of actions that is guaranteed to achieve the goal despite the nondeterminism of the domain. Our approach is based on the representation of the planning domain as a finite state automaton. We use Symbolic Model Checking techniques, in particular Binary Decision Diagrams, to compactly represent and efficiently search the automaton. In this paper we make the following contributions. First, we present a general planning algorithm for conformant planning, which applies to fully nondeterministic domains, with uncertainty in the initial condition and in action effects. The algorithm is based on a breadth-first, backward search, and returns conformant plans of minimal length, if a solution to the planning problem exists, otherwise it terminates concluding that the problem admits no conformant solution. Second, we provide a symbolic representation ...

  12. Probabilistic Model--Checking of Quantum Protocols

    CERN Document Server

    Gay, S; Papanikolaou, N; Gay, Simon; Nagarajan, Rajagopal; Papanikolaou, Nikolaos

    2005-01-01

    We establish fundamental and general techniques for formal verification of quantum protocols. Quantum protocols are novel communication schemes involving the use of quantum-mechanical phenomena for representation, storage and transmission of data. As opposed to quantum computers, quantum communication systems can and have been implemented using present-day technology; therefore, the ability to model and analyse such systems rigorously is of primary importance. While current analyses of quantum protocols use a traditional mathematical approach and require considerable understanding of the underlying physics, we argue that automated verification techniques provide an elegant alternative. We demonstrate these techniques through the use of PRISM, a probabilistic model-checking tool. Our approach is conceptually simpler than existing proofs, and allows us to disambiguate protocol definitions and assess their properties. It also facilitates detailed analyses of actual implemented systems. We illustrate our techniqu...

  13. Statically checked documentation with design patterns

    DEFF Research Database (Denmark)

    Cornils, Aino; Hedin, Görel

    2000-01-01

    Over the past years, along with the increase in popularity of design patterns, some problems with the use of design patterns have been identified. The so-called tracing problem describes the difficulty in documenting software systems using design patterns. Initial approaches to solving the tracing...... problem have focused on guidelines for documenting design pattern roles and rules within a system, but experience has shown that both in the initial design, and especially in later code revisions, it is all too easy for code and documentation to diverge, rendering the documentation misleading. The authors...... present a flexible and extensible tool which enables designers to use design patterns in a safe and efficient way, which checks the design pattern rules, and which semi-automatically documents, and maintains the documentation of a software system...

  14. DEPUTY: analysing architectural structures and checking style

    International Nuclear Information System (INIS)

    The DepUty (dependencies utility) can be classified as a project and process management tool. The main goal of DepUty is to assist by means of source code analysis and graphical representation using UML, in understanding dependencies of sub-systems and packages in CMS Object Oriented software, to understand architectural structure, and to schedule code release in modularised integration. It also allows a new-comer to more easily understand the global structure of CMS software, and to void circular dependencies up-front or re-factor the code, in case it was already too close to the edge of non-maintainability. The authors will discuss the various views DepUty provides to analyse package dependencies, and illustrate both the metrics and style checking facilities it provides

  15. Probabilistic and hybrid model checking deployments for wireless sensor networks

    International Nuclear Information System (INIS)

    In the early stages of system development, model checking is a good practice for examining the WSNs (Wireless Sensor Networks). Model checking involves verifying a system's properties based on the system's finite state model. For varying applications like computers and wireless communication prior to expensive simulations, model checking has become a vital requirement in order to investigate the performance and reliability. In this paper for the first time, we are presenting probabilistic and hybrid model checking tools which are being implemented to analyse and verify the WSN applications and their examples. Here we are categorizing the model checking tools and presenting how they have been used for the investigation of various behaviours of WSN solutions. Consequently, this paper helps readers/researchers to choose the appropriate model checking tool and to get benefited in shape of validating their solutions. The paper has also highlighted the problems of existing model checking tools within WSN domain. (author)

  16. Monoclonal antibodies and cancer

    International Nuclear Information System (INIS)

    The usefulness of radiolabeled monoclonal antibodies for imaging and treatment of human (ovarian) cancer was investigated. A review of tumor imaging with monoclonal antibodies is presented. Special attention is given to factors that influence the localization of the antibodies in tumors, isotope choice and methods of radiolabeling of the monoclonal antibodies. Two monoclonal antibodies, OC125 and OV-TL3, with high specificity for human epithelial ovarian cancer are characterized. A simple radio-iodination technique was developed for clinical application of the monoclonal antibodies. The behavior of monoclonal antibodies in human tumor xenograft systems and in man are described. Imaging of tumors is complicated because of high background levels of radioactivity in other sites than the tumor, especially in the bloodpool. A technique was developed to improve imaging of human tumor xenographs in nude mice, using subtraction of a specific and a non-specific antibody, radiolabeled with 111In, 67Ga and 131I. To investigate the capability of the two monoclonal antibodies, to specifically localize in human ovarian carcinomas, distribution studies in mice bearing human ovarian carcinoma xenografts were performed. One of the antibodies, OC125, was used for distribution studies in ovarian cancer patients. OC125 was used because of availability and approval to use this antibody in patients. The same antibody was used to investigate the usefulness of radioimmunoimaging in ovarian cancer patients. The interaction of injected radiolabeled antibody OC125 with circulating antigen and an assay to measure the antibody response in ovarian cancer patients after injection of the antibody is described. 265 refs.; 30 figs.; 19 tabs

  17. Checking for normality in linear mixed models

    Institute of Scientific and Technical Information of China (English)

    WU Ping; ZHU LiXing; FANG Yun

    2012-01-01

    Linear mixed models are popularly used to fit continuous longitudinal data,and the random effects are commonly assumed to have normal distribution.However,this assumption needs to be tested so that further analysis can be proceeded well.In this paper,we consider the Baringhaus-Henze-Epps-Pulley (BHEP) tests,which are based on an empirical characteristic function.Differing from their case,we consider the normality checking for the random effects which are unobservable and the test should be based on their predictors.The test is consistent against global alternatives,and is sensitive to the local alternatives converging to the null at a certain rate arbitrarily close to 1/(√)n where n is sample size.Furthermore,to overcome the problem that the limiting null distribution of the test is not tractable,we suggest a new method:use a conditional Monte Carlo test (CMCT) to approximate the null distribution,and then to simulate p-values.The test is compared with existing methods,the power is examined,and several examples are applied to illustrate the usefulness of our test in the analysis of longitudinal data.

  18. Analyzing Interoperability of Protocols Using Model Checking

    Institute of Scientific and Technical Information of China (English)

    WUPeng

    2005-01-01

    In practical terms, protocol interoperability testing is still laborious and error-prone with little effect, even for those products that have passed conformance testing. Deadlock and unsymmetrical data communication are familiar in interoperability testing, and it is always very hard to trace their causes. The previous work has not provided a coherent way to analyze why the interoperability was broken among protocol implementations under test. In this paper, an alternative approach is presented to analyzing these problems from a viewpoint of implementation structures. Sequential and concurrent structures are both representative implementation structures, especially in event-driven development model. Our research mainly discusses the influence of sequential and concurrent structures on interoperability, with two instructive conclusions: (a) a sequential structure may lead to deadlock; (b) a concurrent structure may lead to unsymmetrical data communication. Therefore, implementation structures carry weight on interoperability, which may not gain much attention before. To some extent, they are decisive on the result of interoperability testing. Moreover, a concurrent structure with a sound task-scheduling strategy may contribute to the interoperability of a protocol implementation. Herein model checking technique is introduced into interoperability analysis for the first time. As the paper shows, it is an effective way to validate developers' selections on implementation structures or strategies.

  19. Effective ambiguity checking in biosequence analysis

    Directory of Open Access Journals (Sweden)

    Giegerich Robert

    2005-06-01

    Full Text Available Abstract Background Ambiguity is a problem in biosequence analysis that arises in various analysis tasks solved via dynamic programming, and in particular, in the modeling of families of RNA secondary structures with stochastic context free grammars. Several types of analysis are invalidated by the presence of ambiguity. As this problem inherits undecidability (as we show here from the namely problem for context free languages, there is no complete algorithmic solution to the problem of ambiguity checking. Results We explain frequently observed sources of ambiguity, and show how to avoid them. We suggest four testing procedures that may help to detect ambiguity when present, including a just-in-time test that permits to work safely with a potentially ambiguous grammar. We introduce, for the special case of stochastic context free grammars and RNA structure modeling, an automated partial procedure for proving non-ambiguity. It is used to demonstrate non-ambiguity for several relevant grammars. Conclusion Our mechanical proof procedure and our testing methods provide a powerful arsenal of methods to ensure non-ambiguity.

  20. Sufficiency-based Filtering of Invariants for Sequential Equivalence Checking

    OpenAIRE

    Hu, Wei

    2011-01-01

    Verification, as opposed to Testing and Post-Silicon Validation, is a critical step for Integrated Circuits (IC) Design, answering the question â Are we designing the right function?â before the chips are manufactured. One of the core areas of Verification is Equivalence Checking (EC), which is a special yet independent case of Model Checking (MC). Equivalence Checking aims to prove that two circuits, when fed with the same inputs, produce the exact same outputs. There are broadly two ways...

  1. Engineering antibody therapeutics.

    Science.gov (United States)

    Chiu, Mark L; Gilliland, Gary L

    2016-06-01

    The successful introduction of antibody-based protein therapeutics into the arsenal of treatments for patients has within a few decades fostered intense innovation in the production and engineering of antibodies. Reviewed here are the methods currently used to produce antibodies along with how our knowledge of the structural and functional characterization of immunoglobulins has resulted in the engineering of antibodies to produce protein therapeutics with unique properties, both biological and biophysical, that are leading to novel therapeutic approaches. Antibody engineering includes the introduction of the antibody combining site (variable regions) into a host of architectures including bi and multi-specific formats that further impact the therapeutic properties leading to further advantages and successes in patient treatment. PMID:27525816

  2. Interference checking approach with tolerance based on assembly dimension chain

    Institute of Scientific and Technical Information of China (English)

    Wang Lei; Li Yingguang; Wang Wei; and Liao Wenhe

    2012-01-01

    CAD model with nominal dimension is implemented in interference checking of assembly simulation of aircraft complex parts at present, which causes inadequate availability. In order to address this challenging issue, interference checking method with tolerance based on assembly dimension chain was proposed. Worst case and maximum error probability of tolerance of composing loop were used, and CAD models were respectively re-constructed and inserted into simulation system. Before dynamic interference checking, engineering semantic interference condition was set to assembly requirements. Finally, the interface checking result was a basis for reasonability of assembly process and tolerance. A prototype system was developed based on the above research.

  3. Verifying Multi-Agent Systems via Unbounded Model Checking

    Science.gov (United States)

    Kacprzak, M.; Lomuscio, A.; Lasica, T.; Penczek, W.; Szreter, M.

    2004-01-01

    We present an approach to the problem of verification of epistemic properties in multi-agent systems by means of symbolic model checking. In particular, it is shown how to extend the technique of unbounded model checking from a purely temporal setting to a temporal-epistemic one. In order to achieve this, we base our discussion on interpreted systems semantics, a popular semantics used in multi-agent systems literature. We give details of the technique and show how it can be applied to the well known train, gate and controller problem. Keywords: model checking, unbounded model checking, multi-agent systems

  4. 32 CFR Attachment A to Subpart B... - Standard A-National Agency Check With Local Agency Checks and Credit Check (NACLC)

    Science.gov (United States)

    2010-07-01

    ... Access Programs by sect. 4.4 of Executive Order 12958) (60 FR 19825, 3 CFR 1995 Comp., p. 333); (2) “L...) Date and Place of Birth: Corroboration of date and place of birth through a check of...

  5. 25 CFR 115.704 - May we accept for deposit into a trust account retirement checks/payments or pension fund checks...

    Science.gov (United States)

    2010-04-01

    ... checks/payments or pension fund checks/payments even though those funds are not specified in § 115.702... May we accept for deposit into a trust account retirement checks/payments or pension fund checks.../payments or pension fund checks/payments or any funds from sources that are not identified in the table...

  6. In-phantom dosimetric measurements as quality control for brachytherapy. System check and constancy check

    International Nuclear Information System (INIS)

    In brachytherapy dosimetric measurements are difficult due to the inherent dose-inhomogeneities. Typically in routine clinical practice only the nominal dose rate is determined for computer controlled afterloading systems. The region of interest lies close to the source when measuring the spatial dose distribution. In this region small errors in the positioning of the detector, and its finite size, lead to large measurement uncertainties that exacerbate the routine dosimetric control of the system in the clinic. The size of the measurement chamber, its energy dependence, and the directional dependence of the measurement apparatus are the factors which have a significant influence on dosimetry. Although ionisation chambers are relatively large, they are employed since similar chambers are commonly found on clinical brachytherapy units. The dose is determined using DIN 6800 [11] since DIN 6809-2 [12], which deals with dosimetry in brachytherapy, is antiquated and is currently in the process of revision. Further information regarding dosimetry for brachytherapy can be found in textbooks [1] and [2]. The measurements for this work were performed with a HDR (High-Dose-Rate) 192Ir source, type mHDR V2, and a Microselectron Afterloader V2 both from Nucletron/Elekta. In this work two dosimetric procedures are presented which, despite the aforemention difficulties, should assist in performing checks of the proper operation of the system. The first is a system check that measures the dose distribution along a line and is to be performed when first bringing the afterloader into operation, or after significant changes to the system. The other is a dosimetric constancy check, which with little effort can be performed monthly or weekly. It simultaneously verifies the positioning of the source at two positions, the functionality of the system clock and the automatic re-calculation of the source activity.

  7. 42 CFR 60.52 - The student's loan check.

    Science.gov (United States)

    2010-10-01

    ... expenses due before the time of enrollment, the school may obtain the student's endorsement and disburse to... ASSISTANCE LOAN PROGRAM The School § 60.52 The student's loan check. (a) When a school receives from a HEAL lender a loan disbursement check or draft payable jointly to the school and to one of its students,...

  8. 42 CFR 35.47 - Disposition of Government checks.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Disposition of Government checks. 35.47 Section 35... Disposition of Government checks. Notwithstanding any other provisions of this subpart, immediately upon... to the department, agency, or establishment of the Government of the United States issuing...

  9. Checking Consistency of Pedigree Information is NP-complete

    DEFF Research Database (Denmark)

    Aceto, Luca; Hansen, Jens A.; Ingolfsdottir, Anna;

    Consistency checking is a fundamental computational problem in genetics. Given a pedigree and information on the genotypes of some of the individuals in it, the aim of consistency checking is to determine whether these data are consistent with the classic Mendelian laws of inheritance. This probl...

  10. 40 CFR 89.317 - NOX converter check.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false NOX converter check. 89.317 Section 89... Provisions § 89.317 NOX converter check. (a) Prior to its introduction into service, and monthly thereafter... of the NOX generator to the sample inlet of the oxides of nitrogen analyzer which has been set to...

  11. 40 CFR 90.319 - NOX converter check.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false NOX converter check. 90.319 Section 90... Provisions § 90.319 NOX converter check. (a) The efficiency of the converter used for the conversion of NO2... percent of the NO concentration). The NOX analyzer must be in the NO mode so that the span gas does...

  12. 16 CFR 240.12 - Checking customer's use of payments.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Checking customer's use of payments. 240.12... ADVERTISING ALLOWANCES AND OTHER MERCHANDISING PAYMENTS AND SERVICES § 240.12 Checking customer's use of... are furnished and that the seller is not overpaying for them. The customer should expend the...

  13. Affinity purification of antibodies

    Science.gov (United States)

    Antibodies are provided in a variety of formats that includes antiserum, hybridoma culture supernatant or ascites. They can all be used successfully in crude form for the detection of target antigens by immunoassay. However, it is advantageous to use purified antibody in defined quantity to facil...

  14. Therapeutic Recombinant Monoclonal Antibodies

    Science.gov (United States)

    Bakhtiar, Ray

    2012-01-01

    During the last two decades, the rapid growth of biotechnology-derived techniques has led to a myriad of therapeutic recombinant monoclonal antibodies with significant clinical benefits. Recombinant monoclonal antibodies can be obtained from a number of natural sources such as animal cell cultures using recombinant DNA engineering. In contrast to…

  15. Production Of Human Antibodies

    Science.gov (United States)

    Sammons, David W.; Neil, Garry A.

    1993-01-01

    Process for making human monoclonal antibodies based on combination of techniques. Antibodies made active against specific antigen. Process involves in vivo immunization of human B lymphocyte cells in mice. B cells of interest enriched in vitro before fusion. Method potentially applicable to any antigen. Does not rely on use of Epstein-Barr virus at any step. Human lymphocytes taken from any source.

  16. RBC Antibody Screen

    Science.gov (United States)

    ... the baby is Rh-positive and the mother's antibody status is negative for anti-D, the mother is given additional RhIG. This test also may be used to help diagnose autoimmune-related hemolytic anemia ... when a person produces antibodies against his or her own RBC antigens. This ...

  17. Antibody affinity maturation

    DEFF Research Database (Denmark)

    Skjødt, Mette Louise

    Yeast surface display is an effective tool for antibody affinity maturation because yeast can be used as an all-in-one workhorse to assemble, display and screen diversified antibody libraries. By employing the natural ability of yeast Saccharomyces cerevisiae to efficiently recombine multiple DNA...

  18. Statistical Model Checking of Rich Models and Properties

    DEFF Research Database (Denmark)

    Poulsen, Danny Bøgsted

    undecidability issues for the traditional model checking approaches. Statistical model checking has proven itself a valuable supplement to model checking and this thesis is concerned with extending this software validation technique to stochastic hybrid systems. The thesis consists of two parts: the first part...... motivates why existing model checking technology should be supplemented by new techniques. It also contains a brief introduction to probability theory and concepts covered by the six papers making up the second part. The first two papers are concerned with developing online monitoring techniques for...... systems. The fifth paper shows how stochastic hybrid automata are useful for modelling biological systems and the final paper is concerned with showing how statistical model checking is efficiently distributed. In parallel with developing the theory contained in the papers, a substantial part of this work...

  19. Selection of Recombinant Human Antibodies.

    Science.gov (United States)

    Tomszak, Florian; Weber, Susanne; Zantow, Jonas; Schirrmann, Thomas; Hust, Michael; Frenzel, André

    2016-01-01

    Since the development of therapeutic antibodies the demand of recombinant human antibodies is steadily increasing. Traditionally, therapeutic antibodies were generated by immunization of rat or mice, the generation of hybridoma clones, cloning of the antibody genes and subsequent humanization and engineering of the lead candidates. In the last few years, techniques were developed that use transgenic animals with a human antibody gene repertoire. Here, modern recombinant DNA technologies can be combined with well established immunization and hybridoma technologies to generate already affinity maturated human antibodies. An alternative are in vitro technologies which enabled the generation of fully human antibodies from antibody gene libraries that even exceed the human antibody repertoire. Specific antibodies can be isolated from these libraries in a very short time and therefore reduce the development time of an antibody drug at a very early stage.In this review, we describe different technologies that are currently used for the in vitro and in vivo generation of human antibodies. PMID:27236551

  20. Adapting a Tier 2 Behavioral Intervention, Check-in/Check-out, to Meet Students' Needs

    Science.gov (United States)

    Swoszowski, Nicole Cain

    2014-01-01

    Check-in/check-out (CICO) is a resource-efficient, mentor-based, Tier 2 intervention. Various problem behaviors of students with and without disabilities across traditional and alternative school settings have been impacted positively by CICO. Not all students respond to the traditional, five-step approach, however. This article provides an…

  1. Antibody discovery: sourcing of monoclonal antibody variable domains.

    Science.gov (United States)

    Strohl, William R

    2014-03-01

    Historically, antibody variable domains for therapeutic antibodies have been sourced primarily from the mouse IgG repertoire, and typically either chimerized or humanized. More recently, human antibodies from transgenic mice producing human IgG, phage display libraries, and directly from human B lymphocytes have been used more broadly as sources of antibody variable domains for therapeutic antibodies. Of the total 36 antibodies approved by major maket regulatory agencies, the variable domain sequences of 26 originate from the mouse. Of these, four are marketed as murine antibodies (of which one is a mouse-rat hybrid IgG antibody), six are mouse-human chimeric antibodies, and 16 are humanized. Ten marketed antibodies have originated from human antibody genes, three isolated from phage libraries of human antibody genes and seven from transgenic mice producing human antibodies. Five antibodies currently in clinical trials have been sourced from camelids, as well as two from non-human primates, one from rat, and one from rabbit. Additional sources of antibody variable domains that may soon find their way into the clinic are potential antibodies from sharks and chickens. Finally, the various methods for retrieval of antibodies from humans, mouse and other sources, including various display technologies and amplification directly from B cells, are described. PMID:24168292

  2. Radiolabelled antibodies in imaging

    International Nuclear Information System (INIS)

    Recent technological advances make it possible to produce pure (monoclonal) antibodies in unlimited quantities without the need for continuous immunization of animals and to label these antibodies with a variety of radionuclides which can be traced by single-photon computed tomography. An outline review of the state of the art is presented, with particular reference to the imaging of myocardial infarcts and to tumour imaging studies using labelled monoclonal antibodies (sup(99m)Tc and 125I). Lengthy bibliography. (U.K.)

  3. Implementing Model-Check for Employee and Management Satisfaction

    Science.gov (United States)

    Jones, Corey; LaPha, Steven

    2013-01-01

    This presentation will discuss methods to which ModelCheck can be implemented to not only improve model quality, but also satisfy both employees and management through different sets of quality checks. This approach allows a standard set of modeling practices to be upheld throughout a company, with minimal interaction required by the end user. The presenter will demonstrate how to create multiple ModelCheck standards, preventing users from evading the system, and how it can improve the quality of drawings and models.

  4. Pump check valve failures in BWR residual heat removal systems

    International Nuclear Information System (INIS)

    Pump check valve failure mechanisms are often complex and represent a unique challenge, since in many cases, the location of these check valves is critical to proper system operation. Contributing factors identified at the James A. FitzPatrick Nuclear Power Plant included low flow operation of the system as well as excessive flow induced turbulence and cavitation in the system upstream of the check valves. A modification to the system was made to eliminate, or reduce the contribution of the above factors to these valve problems. Several non-standard approaches were taken during the course of modifying the system

  5. Towards an automated checked baggage inspection system augmented with robots

    Science.gov (United States)

    DeDonato, Matthew P.; Dimitrov, Velin; Padır, Taskin

    2014-05-01

    We present a novel system for enhancing the efficiency and accuracy of checked baggage screening process at airports. The system requirements address the identification and retrieval of objects of interest that are prohibited in a checked luggage. The automated testbed is comprised of a Baxter research robot designed by Rethink Robotics for luggage and object manipulation, and a down-looking overhead RGB-D sensor for inspection and detection. We discuss an overview of current system implementations, areas of opportunity for improvements, robot system integration challenges, details of the proposed software architecture and experimental results from a case study for identifying various kinds of lighters in checked bags.

  6. Development of radiolabelling techniques of anti-CEA monoclonal antibody

    International Nuclear Information System (INIS)

    The purpose of this work was to label monoclonal and polyclonal antibodies with 99Tcm such as the ior-CEA-1 antibody and polyclonal IgG using a direct method, to check the radiochemical and biological behavior of labelled products, to prepare it under sterile and apyrogenic conditions as a lyophilized kit and to employ it in clinical trials. In addition, a photoactivation method was used to label polyclonal IgG with 99Tcm and to compare with the established method using mercaptoethanol (2-ME) as the reducing agent. Finally polyclonal IgG was labelled using an indirect method in which a chelator was covalently attached to the protein and the 99Tcm added as glucoheptonate complex. The properties of 99Tcm when labelled with monoclonal and polyclonal antibodies by different methods were assessed by in vitro and in vivo studies

  7. Anti-sulfotyrosine antibodies

    Science.gov (United States)

    Bertozzi, Carolyn R.; Kehoe, John; Bradbury, Andrew M.

    2009-09-15

    The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin.

  8. HIV Antibody Test

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? HIV Antibody and HIV Antigen (p24) Share this page: Was this page helpful? Also known as: HIV Screening Tests; AIDS Test; AIDS Screen; HIV Serology; ...

  9. Antinuclear antibody panel

    Science.gov (United States)

    ... blood may be due to: Chronic liver disease Collagen vascular disease Drug-induced lupus erythematosus Myositis (inflammatory muscle disease) ... Saunders; 2011:chap 51. Read More Antibody Arthritis Collagen vascular disease Drug-induced lupus erythematosus Liver disease Scleroderma Systemic ...

  10. PRODUCTION OF MONOCLONAL ANTIBODIES

    Directory of Open Access Journals (Sweden)

    TOLKOVA E.S.

    2015-01-01

    Full Text Available The article considers the use of monoclonal antibodies in immunotherapy and immunodiagnostics of oncological diseases and their production using hybridoma technolody with flow diagram and technological scheme of manufacturing process

  11. PRODUCTION OF MONOCLONAL ANTIBODIES

    OpenAIRE

    TOLKOVA E.S.

    2015-01-01

    The article considers the use of monoclonal antibodies in immunotherapy and immunodiagnostics of oncological diseases and their production using hybridoma technolody with flow diagram and technological scheme of manufacturing process

  12. Expression of Recombinant Antibodies

    OpenAIRE

    Frenzel, André; Hust, Michael; Schirrmann, Thomas

    2013-01-01

    Recombinant antibodies are highly specific detection probes in research, diagnostics, and have emerged over the last two decades as the fastest growing class of therapeutic proteins. Antibody generation has been dramatically accelerated by in vitro selection systems, particularly phage display. An increasing variety of recombinant production systems have been developed, ranging from Gram-negative and positive bacteria, yeasts and filamentous fungi, insect cell lines, mammalian cells to transg...

  13. Review and analysis of check valve failure data

    Science.gov (United States)

    Todd, M. D.; Casada, D. A.

    Check valve operating problems in recent years have resulted in significant operating transients, increased cost and decreased system availability. There has been, in response, additional attention given to check valves by utilities, as well as the US Nuclear Regulatory Commission and the American Society of Mechanical Engineers Operation and Maintenance Committee. All these organizations have the fundamental goal of ensuring reliable operation of check valves. A key ingredient to an engineering-oriented reliability improvement effort is a thorough understanding of relevant historical experience. Oak Ridge National Laboratory is currently conducting a detailed review of historical failure data available through the Institute of Nuclear Power Operation's Nuclear Plant Reliability Data System. The focus of the review is on check valve failures that have involved significant degradation of the valve internal parts. A variety of parameters are being considered during the review, including size, age, system of service, method of failure discovery, the affected valve parts, attributed causes, and corrective actions.

  14. Monitoring Blood Sugar: The Importance of Checking Blood Sugar Levels

    Science.gov (United States)

    ... 5 Things to Know About Zika & Pregnancy Monitoring Blood Sugar KidsHealth > For Parents > Monitoring Blood Sugar Print ... Other Tests Record Keeping The Importance of Checking Blood Sugar Levels Besides helping to keep blood sugar ...

  15. Imagery versus verbal interpretive cognitive bias modification for compulsive checking.

    Science.gov (United States)

    Black, Melissa J; Grisham, Jessica R

    2016-08-01

    Pathological doubting and checking is a common symptom presentation in obsessive-compulsive disorder (OCD). Previous research has established that compulsive checkers do not display an actual memory deficit, but lack confidence in their memories and experience intolerance of uncertainty regarding the completion of tasks. We investigated whether interpretive cognitive bias modification (CBM-I) reduced memory distrust and intolerance of uncertainty in a nonclinical sample. We also examined the possible enhancement of CBM-I for OCD through imagery training. The results provide evidence that participants who received positive imagery CBM-I training may have interpreted novel ambiguous checking scenarios more adaptively and endorsed negative checking beliefs less relative to participants in the control imagery CBM-I condition. Findings on behavioural checking tasks did not indicate any specific response to CBM-I training. Future research may translate these suggestive findings into a useful adjunct to traditional strategies targeting maladaptive OCD beliefs. PMID:27300752

  16. Decentralized Checking Context Inconsistency in Ubiquitous Mobile Computing Environments

    Science.gov (United States)

    Zhang, Daqiang; Yang, Zhijun; Huang, Hongyu; Zou, Qin

    Contexts are often noisy in ubiquitous mobile computing environments due to user mobility, unreliable wireless connectivity and resource constraints. Various schemes have been proposed to check context inconsistency for ubiquitous mobile applications. However, most of them require central control. This requirement inhibits their working in ubiquitous mobile environments, which are characterized by the asynchronous coordination among computing devices. In this paper, we propose DCCI scheme - Decentralized Checking Context Inconsistency for ubiquitous mobile applications by exploiting the preference-based locality that denotes context inconsistency occurs among the nodes that impose various restrictions on the same context. According to this locality, DCCI constructs a preference-based shortcut structure to check inconsistency within shortcuts. Extensive experiments show that DCCI can accurately and efficiently check context inconsistency in a fully distributed manner.

  17. Exercise May Keep Diabetes in Check During Pregnancy

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160113.html Exercise May Keep Diabetes in Check During Pregnancy Short ... university news release. "We advise all women to exercise during pregnancy, as long as there aren't ...

  18. Skin Cancer Check? Do Some Sole-Searching

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159385.html Skin Cancer Check? Do Some Sole-Searching Deadly melanoma is ... wear-and-tear appears to promote the deadly skin cancer in at least one place where the sun ...

  19. 31 CFR 240.15 - Checks issued to deceased payees.

    Science.gov (United States)

    2010-07-01

    ...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE INDORSEMENT AND PAYMENT OF CHECKS... a financial institution, it will be paid by Treasury without the submission of documentary proof...

  20. Automatic checking system of radioactivity in motor-cars 'AKKORD'

    International Nuclear Information System (INIS)

    A monitoring device has been developed for an automated checking of all vehicles leaving or entering a nuclear installation against uncontrolled lost of radioactive material. This device is an excellent tool for radioactive material flow control. (orig.)

  1. Ist-Versteuerung und ein Cross-Check-Verfahren

    OpenAIRE

    Barbara Hendricks

    2004-01-01

    Auch Dr. Barbara Hendricks, Parlamentarische Staatssekretärin im Bundesfinanzministerium, brachte einen Wechsel von der gegenwärtigen Soll-Besteuerung zur Ist-Besteuerung verbunden mit einem Cross-Check in die Diskussion ein.

  2. The impact of debit card regulation on checking account fees

    OpenAIRE

    Richard J. Sullivan

    2013-01-01

    Starting in 2011, when new regulations capped the interchange fees paid to banks for debit card transactions, some news reports predicted banks might increase checking account fees. The cap reduced many banks' revenue and the concern was that they might offset their losses by charging more for checking accounts. Sullivan examines data from broad samples of banks and finds that many large banks raised fees—but among the thousands of smaller banks that had been exempted from the regulations, so...

  3. Check Point:极速灵动安全

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    8月25日,Check Point软件技术有限公司推出了号称业界速度最快的安全网关。这款名为Check Point 61000的安全系统能为数据中心、电信和云服务供应商提供可扩展的性能。

  4. Efficient Checking of Individual Rewards Properties in Markov Population Models

    OpenAIRE

    Bortolussi, Luca; Hillston, Jane

    2015-01-01

    In recent years fluid approaches to the analysis of Markov populations models have been demonstrated to have great pragmatic value. Initially developed to estimate the behaviour of the system in terms of the expected values of population counts, the fluid approach has subsequently been extended to more sophisticated interrogations of models through its embedding within model checking procedures. In this paper we extend recent work on checking CSL properties of individual agents within a Marko...

  5. Dynamic State Space Partitioning for External Memory Model Checking

    DEFF Research Database (Denmark)

    Evangelista, Sami; Kristensen, Lars Michael

    2009-01-01

    We describe a dynamic partitioning scheme usable by model checking techniques that divide the state space into partitions, such as most external memory and distributed model checking algorithms. The goal of the scheme is to reduce the number of transitions that link states belonging to different...... partitions, and thereby limit the amount of disk access and network communication. We report on several experiments made with our verification platform ASAP that implements the dynamic partitioning scheme proposed in this paper....

  6. Model checking biological systems described using ambient calculus

    DEFF Research Database (Denmark)

    Mardare, Radu Iulian; Priami, Corrado; Qualia, Paola; Vagin, Oleksander

    2005-01-01

    Model checking biological systems described using ambient calculus. In Proc. of the second International Workshop on Computational Methods in Systems Biology (CMSB04), Lecture Notes in Bioinformatics 3082:85-103, Springer, 2005.......Model checking biological systems described using ambient calculus. In Proc. of the second International Workshop on Computational Methods in Systems Biology (CMSB04), Lecture Notes in Bioinformatics 3082:85-103, Springer, 2005....

  7. Inferring loop invariants by mutation, dynamic analysis, and static checking

    OpenAIRE

    Galeotti, J.P.; Furia, C.A.; May, E.; Fraser, G.; Zeller, A.

    2015-01-01

    Verifiers that can prove programs correct against their full functional specification require, for programs with loops, additional annotations in the form of loop invariants - properties that hold for every iteration of a loop. We show that significant loop invariant candidates can be generated by systematically mutating postconditions; then, dynamic checking (based on automatically generated tests) weeds out invalid candidates, and static checking selects provably valid ones. We present a fr...

  8. The NHS health check programme in England: a qualitative study.

    Science.gov (United States)

    Perry, Catherine; Thurston, Miranda; Alford, Simon; Cushing, Jill; Panter, Lee

    2016-03-01

    Despite an extensive evidence-base linking patterns of health with social determinants, recent public health policy has emphasized 'lifestyle diseases' and risk factor modification through behavioural and pharmacological intervention. In England, one manifestation of this has been the launch of the National Health Service Health Check programme. This paper reports findings from a small-scale qualitative study exploring experiences of engaging with a community-based health check in Knowsley, England, among 17 males and 19 females, with varying levels of risk for cardiovascular disease, who agreed to be contacted for the purpose of research at the time they underwent their check. Analysis revealed that the community-based nature of the checks provided opportunities for people to find out more about their health who might not otherwise have done so. Participants expressed a range of responses to the communication of the risk score, often revealing their confusion about its meaning. Changes in behaviour were identified, which participants connected with having had a check. This study raises questions about where, how and by whom health checks are delivered. Emphasis on health checks reflects the dominant individualist ideology, but this study also suggests that the process provides opportunities to enable and empower individuals, albeit in small ways. However, they remain a 'downstream' approach to public health, emphasizing medical and behavioural options for risk factor reduction rather than focussing on primary prevention through changes to the wider environment. Furthermore, although developed as a central feature of the UK's strategy to reduce health inequalities, health checks may widen them. PMID:25073761

  9. Query containment checking as a view updating problem

    OpenAIRE

    Farré Tost, Carles; Teniente López, Ernest; Urpí Tubella, Antoni

    1998-01-01

    In this paper we present a new approach that handles query containment problems by expressing them as a view updating problem. Since this approach is independent of any particular view updating method, it provides a general framework that joins research efforts in both the query containment checking and view updating fields. In particular, the larger development of current view updating technology allows us to check properly query containment when considering negative-der...

  10. Improved Bounded Model Checking for the Universal Fragment of CTL

    Institute of Scientific and Technical Information of China (English)

    Liang Xu; Wei Chen; Yan-Yan Xu; Wen-Hui Zhang

    2009-01-01

    SAT-based bounded model checking (BMC) has been introduced as a complementary technique to BDD-based symbolic model checking in recent years, and a lot of successful work has been done in this direction. The approach was first introduced by A. Biere et al. in checking linear temporal logic (LTL) formulae and then also adapted to check formulae of the universal fragment of computation tree logic (ACTL) by W. Penczek et al. As the efficiency of model checking is still an important issue, we present an improved BMC approach for ACTL based on Penczek's method. We consider two aspects of the approach. One is reduction of the number of variables and transitions in the k-model by distinguishing the temporal operator EX from the others. The other is simplification of the transformation of formulae by using uniform path encoding instead of a disjunction of all paths needed in the k-model. With these improvements, for an ACTI, formula, the length of the final encoding of the formula in the worst case is reduced. The improved approach is implemented in the tool BMV and is compared with the original one by applying both to two well known examples, mutual exclusion and dining philosophers. The comparison shows the advantages of the improved approach with respect to the efficiency of model checking.

  11. Assessment of diagnostic methods for determining degradation of check valves

    International Nuclear Information System (INIS)

    The Oak Ridge National Laboratory (ORNL) has carried out a comprehensive aging assessment of check valves in support of the Nuclear Plant Aging Research (NPAR) program. This paper provides a summary of the ORNL check valve aging assessment with emphasis on the identification, evaluation, and application of check valve monitoring methods and techniques. Several check valve monitoring methods are described and compared. These methods include: acoustic emission monitoring, ultrasonic inspection, magnetic flux signature analysis (MFSA), external magnetics. These diagnostic technologies were shown to be useful in determining check valve condition (e.g., disc position, disc motion, and seat leakage), although none of the methods was by itself, successful in monitoring all three condition indicators. The combination of acoustic emission with either ultrasonics or one of the magnetic technologies, however, yields a monitoring system that succeeds in providing the sensitivity to detect all major check valve operating conditions. Other areas covered in the paper include descriptions of relevant regulatory issues, utility group activities, and interactions ORNL has had with outside organizations for the purpose of disseminating research results

  12. An Extended Ontology Model and Ontology Checking Based on Description Logics

    Institute of Scientific and Technical Information of China (English)

    王洪伟; 蒋馥; 吴家春

    2004-01-01

    Ontology is defined as an explicit specification of a conceptualization. In this paper, an extended ontology model was constructed using description logics, which is a 5-tuples including term set, individual set, term definition set, instantiation assertion set and term restriction set. Based on the extended model, the issue on ontology checking was studied with the conclusion that the four kinds of term checking, including term satisfiability checking, term subsumption checking, term equivalence checking and term disjointness checking, can be reduced to the satisfiability checking, and satisfiability checking can be transformed into instantiation consistence checking.

  13. Optimizing selection of large animals for antibody production by screening immune response to standard vaccines.

    Science.gov (United States)

    Thompson, Mary K; Fridy, Peter C; Keegan, Sarah; Chait, Brian T; Fenyö, David; Rout, Michael P

    2016-03-01

    Antibodies made in large animals are integral to many biomedical research endeavors. Domesticated herd animals like goats, sheep, donkeys, horses and camelids all offer distinct advantages in antibody production. However, their cost of use is often prohibitive, especially where poor antigen response is commonplace; choosing a non-responsive animal can set a research program back or even prevent experiments from moving forward entirely. Over the course of production of antibodies from llamas, we found that some animals consistently produced a higher humoral antibody response than others, even to highly divergent antigens, as well as to their standard vaccines. Based on our initial data, we propose that these "high level responders" could be pre-selected by checking antibody titers against common vaccines given to domestic farm animals. Thus, time and money can be saved by reducing the chances of getting poor responding animals and minimizing the use of superfluous animals. PMID:26775851

  14. 45 CFR 205.32 - Procedures for issuance of replacement checks.

    Science.gov (United States)

    2010-10-01

    ...) Issue a stop payment order on the original AFDC check through appropriate banking procedures; and (ii... replacement check, a recipient is required to report a lost or stolen AFDC check to the police or...

  15. Action plans for motor-operated valves and check valves

    International Nuclear Information System (INIS)

    The proper performance of motor-operated valves (MOVs) and check valves is necessary for the safety operation of a nuclear power plant. Problems have been experienced, however, with these valves for many years. Currently, the US Nuclear Regulatory Commission (NRC) and the nuclear industry have a number of activities under way to provide assurance that MOVs and check valves will successfully perform their safety functions when needed. The Mechanical Engineering Branch (EMEB) of the NRC Office of Nuclear Reactor Regulation has been assigned the responsibility of coordinating NRC activities and monitoring industry activities regarding MOVs and check valves. To meet this responsibility, EMEB has prepared action plans to provide assurance of the proper performance of these valves. Among the staff activities described in the action plans is the consideration of the need to revise the regulations to clarify the inservice testing (IST) requirements for these valves. The need for regulatory guidance for the development of acceptable IST programs, as well as for other licensee activities relating to the performance of MOVs and check valves, will also be evaluated. In addition, NRC personnel will have to verify, in a consistent manner, implementation of licensee commitments in response to NRC generic letters and bulletins. Another important aspect of the action plans is the provision for the NRC staff to provide assistance, where appropriate, to the industry in its efforts to address MOV and check valve issues. Finally, the action plans include a tentative schedule for accomplishing the described staff activities

  16. Independent checks of linear accelerators equipped with multileaf collimators

    International Nuclear Information System (INIS)

    National Radiation Protection Institute (NRPI) provides independent checks of therapeutic equipment as a part of state supervision. In the end of 2003, the audit was broaden for linear accelerators equipped with multileaf collimators (MLC). NRPI provides TLD postal audits and on-site independent checks. This contribution describes tests for multileaf collimators and intensity modulated radiation therapy (IMRT) technique that are accomplished within the independent on-site check of linear accelerators. The character and type of tests that are necessary to pursue for multileaf collimator depends on application technique. There are three basic application of the MLC. The first we call 'static MLC' and it serves for replacing conventional blocking or for adjusting the field shape to match the beam's-eye view projection of a planning target volume during an arc rotation of the x-ray beam. This procedure is called conformal radiotherapy. The most advanced technique with MLC is intensity modulated radiation therapy. The dose can be delivered to the patient with IMRT in various different ways: dynamic MLC, segmented MLC and IMRT arc therapy. Independent audits represent an important instrument of quality assurance. Methodology for independent check of static MLC was successfully verified on two types of accelerators: Varian and Elekta. Results from pilot measurements with dynamic MLC imply that the methodology is applicable for Varian accelerators. In the future, the experience with other types of linear accelerators will contribute to renovation, modification, and broaden independent checks methodology. (authors)

  17. Intelligent Data Visualization for Cross-Checking Spacecraft System Diagnosis

    Science.gov (United States)

    Ong, James C.; McCann, Robert S.; Remolina, Emilio; Breeden, David; Stroozas, Brett A.; Mohammed, John L.

    2012-01-01

    Any reasoning system is fallible, so crew members and flight controllers must be able to cross-check automated diagnoses of spacecraft or habitat problems by considering alternate diagnoses and analyzing related evidence. Cross-checking improves diagnostic accuracy because people can apply information processing heuristics, pattern recognition techniques, and reasoning methods that the automated diagnostic system may not possess. Over time, cross-checking also enables crew members to become comfortable with how the diagnostic reasoning system performs, so the system can earn the crew s trust. We developed intelligent data visualization software that helps users cross-check automated diagnoses of system faults more effectively. The user interface displays scrollable arrays of timelines and time-series graphs, which are tightly integrated with an interactive, color-coded system schematic to show important spatial-temporal data patterns. Signal processing and rule-based diagnostic reasoning automatically identify alternate hypotheses and data patterns that support or rebut the original and alternate diagnoses. A color-coded matrix display summarizes the supporting or rebutting evidence for each diagnosis, and a drill-down capability enables crew members to quickly view graphs and timelines of the underlying data. This system demonstrates that modest amounts of diagnostic reasoning, combined with interactive, information-dense data visualizations, can accelerate system diagnosis and cross-checking.

  18. Helical tomotherapy quality assurance with ArcCHECK

    International Nuclear Information System (INIS)

    To design a quality assurance (QA) procedure for helical tomotherapy that measures multiple beam parameters with 1 delivery and uses a rotating gantry to simulate treatment conditions. The customized QA procedure was preprogrammed on the tomotherapy operator station. The dosimetry measurements were performed using an ArcCHECK diode array and an A1SL ion chamber inserted in the central holder. The ArcCHECK was positioned 10 cm above the isocenter so that the 21-cm diameter detector array could measure the 40-cm wide tomotherapy beam. During the implementation of the new QA procedure, separate comparative measurements were made using ion chambers in both liquid and solid water, the tomotherapy onboard detector array, and a MapCHECK diode array for a period of 10 weeks. There was good agreement (within 1.3%) for the beam output and cone ratio obtained with the new procedure and the routine QA measurements. The measured beam energy was comparable (0.3%) to solid water measurement during the 10-week evaluation period, excluding 2 of the 10 measurements with unusually high background. The symmetry reading was similarly compromised for those 2 weeks, and on the other weeks, it deviated from the solid water reading by ∼2.5%. The ArcCHECK phantom presents a suitable alternative for performing helical tomotherapy QA, provided the background is collected properly. The proposed weekly procedure using ArcCHECK and water phantom makes the QA process more efficient

  19. The use of check valve performance data to support new concepts (probabilistic risk assessment, condition monitoring) for check valve program

    Energy Technology Data Exchange (ETDEWEB)

    Hart, K.A.; Gower, D.

    1996-12-01

    The concept of developing an integrated check valve database based on the Nuclear Power Reliability Data System (NPRDS) data was presented at the last Symposium. The Nuclear Industry Check Valve Group (NIC), working in cooperation with the Oak Ridge National Laboratory (ORNL), has completed an operational database of check valve performance from 1984 to the present. NIC has committed to the nuclear industry to periodically update the data and maintain this information accessible. As the new concepts of probabilistic risk analysis and condition monitoring are integrated into the American Society of Mechanical Engineers (ASME) Code, a critical element will be performance data. From check valve performance data, feasible failure modes and rates can be established. When a failure rate or frequency of failures can be established based on a significant enough population (sampling), a more solid foundation for focusing resources and determining appropriate frequencies and testing can be determined. The presentation will give the updated status of the NIC Check Valve Performance Database covering (1) methodology used to combine the original ORNL data; (2) process/controls established for continuing update and refinement of the data; (3) discussion of how this data is being utilized by (a) OM-22 for condition monitoring, and (b) risk-based inservice testing work of Westinghouse Owners` Group; and (4) results/trends of data evaluations. At the 1994 Symposium, ORNL provided an update as of 1991 to their original work of 1984 -1990 which they had performed to characterize check valve degradations and failures in the nuclear industry. These characterizations will be updated to 1995 and additional reviews provided to give insight into the current condition and trends of check valve performance.

  20. A Spatialization-based Method for Checking and Updating Metadata

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    In this paper the application of spatialization technology on metadata quality check and updating was discussed. A new method based on spatialization was proposed for checking and updating metadata to overcome the deficiency of text based methods with the powerful functions of spatial query and analysis provided by GIS software. This method employs the technology of spatialization to transform metadata into a coordinate space and the functions of spatial analysis in GIS to check and update spatial metadata in a visual environment. The basic principle and technical flow of this method were explained in detail, and an example of implementation using ArcMap of GIS software was illustrated with a metadata set of digital raster maps. The result shows the new method with the support of interaction of graph and text is much more intuitive and convenient than the ordinary text based method, and can fully utilize the functions of GIS spatial query and analysis with more accuracy and efficiency.

  1. A Metric Encoding for Bounded Model Checking (extended version)

    CERN Document Server

    Pradella, Matteo; Pietro, Pierluigi San

    2009-01-01

    In Bounded Model Checking both the system model and the checked property are translated into a Boolean formula to be analyzed by a SAT-solver. We introduce a new encoding technique which is particularly optimized for managing quantitative future and past metric temporal operators, typically found in properties of hard real time systems. The encoding is simple and intuitive in principle, but it is made more complex by the presence, typical of the Bounded Model Checking technique, of backward and forward loops used to represent an ultimately periodic infinite domain by a finite structure. We report and comment on the new encoding technique and on an extensive set of experiments carried out to assess its feasibility and effectiveness.

  2. Applied Bounded Model Checking for Interlocking System Designs

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Peleska, Jan; Pinger, Ralf

    2013-01-01

    In this article the verification and validation of interlocking systems is investigated. Reviewing both geographical and route-related interlocking, the verification objectives can be structured from a perspective of computer science into (1) verification of static semantics, and (2) verification...... of behavioural (operational) semantics. The former checks that the plant model – that is, the software components reflecting the physical components of the interlocking system – has been set up in an adequate way. The latter investigates trains moving through the network, with the objective to uncover potential...... safety violations. From a formal methods perspective, these verification objectives can be approached by theorem proving, global, or bounded model checking. This article explains the techniques for application of bounded model checking techniques, and discusses their advantages in comparison...

  3. Self-checking state machine realizations in CMOS

    Science.gov (United States)

    Lala, P. K.

    1994-06-01

    In this reporting period, we have studied the currently available techniques for designing totally self-check checkers for m-out-of-n codes. Such codes can be used for state assignment in self-checking state machines. The major advantage of m-out-of-n codes is that they can detect single and unidirectional multibit errors in the encoded information bits. Thus, if a circuit is designed such that its output forms an m-out-of-n code, any fault in the circuit which creates a single bit error or unidirectional multibit error at the output can be detected on-line. On-line error detection, also known as self-checking, can be accomplished by using a checker to monitor the circuit output. The output of the checker is 01 or 10 if there is no fault in the circuit under test or in the checker itself, otherwise the output will be 00 or 11.

  4. Applied Bounded Model Checking for Interlocking System Designs

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Peleska, Jan; Pinger, Ralf

    2014-01-01

    In this paper the verification and validation of interlocking systems is investigated. Reviewing both geographical and route-related interlocking, the verification objectives can be structured from a perspective of computer science into (1) verification of static semantics, and (2) verification of...... behavioural (operational) semantics. The former checks that the plant model – that is, the software components reflecting the physical components of the interlocking system – has been set up in an adequate way. The latter investigates trains moving through the network, with the objective to uncover potential...... safety violations. From a formal methods perspective, these verification objectives can be approached by theorem proving, global, or bounded model checking. This paper explains the techniques for application of bounded model checking techniques, and discusses their advantages in comparison to the...

  5. Model Checking-Based Testing of Web Applications

    Institute of Scientific and Technical Information of China (English)

    ZENG Hongwei; MIAO Huaikou

    2007-01-01

    A formal model representing the navigation behavior of a Web application as the Kripke structure is proposed and an approach that applies model checking to test case generation is presented. The Object Relation Diagram as the object model is employed to describe the object structure of a Web application design and can be translated into the behavior model. A key problem of model checking-based test generation for a Web application is how to construct a set of trap properties that intend to cause the violations of model checking against the behavior model and output of counterexamples used to construct the test sequences.We give an algorithm that derives trap properties from the object model with respect to node and edge coverage criteria.

  6. LOAD-CHECK. Disposal planning for LWR fuel elements

    International Nuclear Information System (INIS)

    With the changes of the German atomic law from November 8, 2011 the operation licensing of LWR plants expire latest 2022, for eight NPPs the operation licenses are already expired. In order to optimize the fuel element management in the still operated but also in the decommissioned nuclear power plants the computer code module LOAD-CHECK was developed. LOAD-CHECK allows the foresight container planning for an optimized schedule and the container amount for loading campaigns esp. in case of the disposal of special fuel elements (MOX fuel elements or high-burnup fuel elements). The program can also be used a s tool for development of transport licensing and storage licensing according of CASTOR registered V casks. In the contribution the LOAD-CHECK program for the PWR and BWR fuel element disposal management in CASTOR registered B casks is presented.

  7. MOM: A meteorological data checking expert system in CLIPS

    Science.gov (United States)

    Odonnell, Richard

    1990-01-01

    Meteorologists have long faced the problem of verifying the data they use. Experience shows that there is a sizable number of errors in the data reported by meteorological observers. This is unacceptable for computer forecast models, which depend on accurate data for accurate results. Most errors that occur in meteorological data are obvious to the meteorologist, but time constraints prevent hand-checking. For this reason, it is necessary to have a 'front end' to the computer model to ensure the accuracy of input. Various approaches to automatic data quality control have been developed by several groups. MOM is a rule-based system implemented in CLIPS and utilizing 'consistency checks' and 'range checks'. The system is generic in the sense that it knows some meteorological principles, regardless of specific station characteristics. Specific constraints kept as CLIPS facts in a separate file provide for system flexibility. Preliminary results show that the expert system has detected some inconsistencies not noticed by a local expert.

  8. Prediction of antibody persistency from antibody titres to natalizumab

    DEFF Research Database (Denmark)

    Jensen, Poul Erik H; Koch-Henriksen, Nils; Sellebjerg, Finn; Sørensen, Per S

    2012-01-01

    In a subgroup of patients with multiple sclerosis natalizumab therapy causes generation of anti-natalizumab antibodies that may be transient or persistent. It is recommended to discontinue natalizumab therapy in persistently antibody-positive patients.......In a subgroup of patients with multiple sclerosis natalizumab therapy causes generation of anti-natalizumab antibodies that may be transient or persistent. It is recommended to discontinue natalizumab therapy in persistently antibody-positive patients....

  9. Check Point推出NGX版本Connectra SSL VPN

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    6月7日,互联网安全解决方案供应商Check Point软件技术有限公司在美国宣布推出Connectra NGX,这是其SSL VPN解决方案的增强版本。Connectra NGX充分发挥了Check Point最近推出的NGX平台的全新连接功能,以及支持中央化安全监控及维护的SmartCenter。Connectra NGX有下列特点:

  10. An analysis of prostate patient computer plan checks

    International Nuclear Information System (INIS)

    Full text: The physics group at the Cancer Therapy Centre, Liverpool Hospital performs independent quality assurance checks on all radiation treatment fields. These checks involve calculating doses from the prescribed monitor units using data independent of the planning computer. In the physics check the dose at the isocentre or other prescription point is calculated and usually no consideration is given to patient inhomogeneities and curvature. This dose is compared with the dose at the same position as derived from the Varian CADPLAN treatment planning system (CTPS). For the treatment of prostate cancer, the most common technique involves four 6MV x-ray fields: AP, PA and two laterals with the dose prescribed to the isocentre as recommended by I.C.R.U. Report 50 ('Prescribing, Recording and Reporting Photon Beam Therapy', International Commission on Radiation Units and Measurements, Bethesda, Maryland, U.S.A., 1993). This work attempts to determine the cause and magnitude of dose variations between CTPS and -physics check derived doses in prostate patients. A set of 50 prostate patients, treated with the above technique, was selected for the study. The physics checks were evaluated and the average patient separations and dose variations were determined. These dose variations were between zero and 5% (median 4%). A median isocentre dose difference of 6.2% between using and not using a bone inhomogeneity correction method has been observed in 6MV x-ray arc treatments of the prostate (Nemeth et al, Med. Dosim., 18:171-177, 1993). The physics check method was benchmarked in a homogeneous solid water phantom using a PTW Farmer type ionisation chamber with the four field prostate technique and compared with the CTPS derived doses. This showed good agreement. An anthropomorphic phantom was treated with the above prostate technique, using a field size of 9x9 cm2 for all four fields. The CTPS and physics check derived doses at the isocentre were calculated and compared

  11. The check and error analysis of the BRDF experiment bench

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, a detailed introduction is given to the check method of the BRDF experiment bench which is built on our own. Measurement is made on the BRDF of the standard white plate made of polytetrafluoroethylene(PTFE) with reference to the existing standard white plate whose surface reflectance is known and by the method of theory approximate and relative comparison. On the basis of that, the BRDF value of the standard white plate in the wave band of 0. 6328 μm is given and the experiment bench is checked, the relative error of the experiment bench being within 20%.

  12. Using Model Checking to Validate AI Planner Domain Models

    Science.gov (United States)

    Penix, John; Pecheur, Charles; Havelund, Klaus

    1999-01-01

    This report describes an investigation into using model checking to assist validation of domain models for the HSTS planner. The planner models are specified using a qualitative temporal interval logic with quantitative duration constraints. We conducted several experiments to translate the domain modeling language into the SMV, Spin and Murphi model checkers. This allowed a direct comparison of how the different systems would support specific types of validation tasks. The preliminary results indicate that model checking is useful for finding faults in models that may not be easily identified by generating test plans.

  13. Spell-checking in Spanish: the case of diacritic accents

    OpenAIRE

    Atserias Batalla, Jordi; Fuentes Fort, Maria; Nazar, Rogelio; Renau, Irene

    2012-01-01

    This article presents the problem of diacritic restoration (or diacritization) in the context of spell-checking, with the focus on an orthographically rich language such as Spanish. We argue that despite the large volume of work published on the topic of diacritization, currently available spell-checking tools have still not found a proper solution to the problem in those cases where both forms of a word are listed in the checker’s dictionary. This is the case, for instance, when a word form ...

  14. Is raised helicobacter pylori antibody titre enough to decide retreatment

    International Nuclear Information System (INIS)

    Background: Helicobacter pylori infection causes a rise in its antibodies which take almost a year to come to baseline following successful eradication treatment. Checking these values in between a year may give falsely high values and many patients may thus be over treated. Aims: To serially determine Helicobacter pylori antibody titres in patients after giving them triple therapy for H. pylori eradication and see how these values drop over time. Study type, Settings and duration: Longitudinal study conducted in Department of Gastroenterology and Hepatology, Pakistan Medical Research Council, Research Centre, Jinnah Post Graduate Medical Centre, Karachi, from May 2006 to April 2010. Subjects and Methods: Over the period of four years, 186 patients who were found positive for campylobacter like organism test during endoscopy were further tested for anti H. pylori IgG titre before being treated for H. pylori. Patients were given triple therapy comprising of Omeprazole (20 mg twice daily), Amoxicillin (1 gm twice daily) and Clarythromycin (500 mg twice daily) for a week and were followed at 1, 3, 6 and 12 months to check symptomatic relief and they were tested again for H.Pylori antibody titres. Data was collected on pre-designed proforma which included patient's demography, symptoms and diagnosis. Results: Out of 186 patients who had a positive campylobacter like organism test, 173 patients consented to participate in the study. Serology for H.Pylori was positive in 119(68%) cases. A decline in mean antibody titres was observed as 11%, 21.5%, 54.7% and 59.2% at 1, 3, 6 and 12 months respectively. Conclusions: Sensitivity of serology for diagnosing H. pylori infection is good but using these as a tool for monitoring response to treatment is doubtful. A slow drop in H.pylori antibodies was seen over 12 months and therefore, physicians are cautioned not to retreat the already treated cases till about one year post treatment. Policy message: H. pylori antibodies should

  15. Prediction of Antibody Epitopes

    DEFF Research Database (Denmark)

    Nielsen, Morten; Marcatili, Paolo

    2015-01-01

    self-proteins. Given the sequence or the structure of a protein of interest, several methods exploit such features to predict the residues that are more likely to be recognized by an immunoglobulin.Here, we present two methods (BepiPred and DiscoTope) to predict linear and discontinuous antibody...

  16. Monoclonal antibodies in myeloma

    DEFF Research Database (Denmark)

    Sondergeld, P.; van de Donk, N. W. C. J.; Richardson, P. G.;

    2015-01-01

    The development of monoclonal antibodies (mAbs) for the treatment of disease goes back to the vision of Paul Ehrlich in the late 19th century; however, the first successful treatment with a mAb was not until 1982, in a lymphoma patient. In multiple myeloma, mAbs are a very recent and exciting add...

  17. Red Blood Cell Antibody Identification

    Science.gov (United States)

    ... limited. Home Visit Global Sites Search Help? RBC Antibody Identification Share this page: Was this page helpful? Also known as: Alloantibody Identification; Antibody ID, RBC; RBC Ab ID Formal name: Red ...

  18. Anti-insulin antibody test

    Science.gov (United States)

    Insulin antibodies - serum; Insulin Ab test ... Normally, there are no antibodies against insulin in your blood. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or ...

  19. The Art of Making Antibodies.

    Science.gov (United States)

    Headon, Denis R.

    1986-01-01

    Provides background information for teachers on the nature and production of antibodies. Points out that the production of monoclonal antibodies blends the malignant with the beneficial to create a medical tool of exciting potential. (JN)

  20. Lupus anticoagulants and antiphospholipid antibodies

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000547.htm Lupus anticoagulants and antiphospholipid antibodies To use the sharing features on this page, please enable JavaScript. Lupus anticoagulants are antibodies against substances in the lining ...

  1. Recombinant antibodies and tumor targeting

    OpenAIRE

    Sheikholvaezin, Ali

    2006-01-01

    Different antibody derived constructs are rapidly advancing as putative tools for treatment of malignant diseases. Antibody engineering has added significant new technologies to modify size, affinities, solubility, stability and biodistribution properties for immunoconjugates. In the present thesis, the aim was to increase our knowledge on how new recombinant antibodies could be tailored to optimize localization to experimental tumors in mice. One hybridoma, producing the monoclonal antibody ...

  2. Antibody Engineering and Therapeutics Conference

    OpenAIRE

    Larrick, James W; Parren, Paul WHI; Huston, James S; Plückthun, Andreas; Bradbury, Andrew; Tomlinson, Ian M; Chester, Kerry A.; Burton, Dennis R.; Adams, Gregory P; Weiner, Louis M.; Scott, Jamie K; Alfenito, Mark R; Veldman, Trudi; Reichert, Janice M

    2013-01-01

    The Antibody Engineering and Therapeutics conference, which serves as the annual meeting of The Antibody Society, will be held in Huntington Beach, CA from Sunday December 8 through Thursday December 12, 2013. The scientific program will cover the full spectrum of challenges in antibody research and development, and provide updates on recent progress in areas from basic science through approval of antibody therapeutics. Keynote presentations will be given by Leroy Hood (Institute of System Bi...

  3. Evaluation of phenotypic factors for anti-rabies antibody in vaccinated pet dogs.

    Science.gov (United States)

    Savaliya, Bhumika F; Mathakiya, R A; Bhanderi, B B; Jhala, M K

    2015-12-01

    The aims of this study were to investigate various factors associated with protective anti-rabies antibody status (0.5 EU/ml) in vaccinated pet dogs and anti-rabies antibody status in unvaccinated stray dogs. One hundred and seven serum samples were collected from vaccinated pet dogs, out of these 58 (62.36 %) dogs showed antibody titre above 0.5 EU/ml. All the dogs were divided into different groups based on age, sex, breed, vaccine brand and time of vaccination after last vaccine to assess the relationship of these factors with vaccinal immune response. One way analysis of variance was performed in graphpad prism software to check the effect of all these factors. Statistical analysis of ELISA titres of pet dog serum samples suggested that age, sex, breed and vaccine brands have no significant effect on the anti-rabies antibody titres. To check anti-rabies antibody status in stray dogs 53 serum samples were collected and only one out of 53 (1.88 %) stray dogs showed anti-rabies antibody titre above 0.5 EU/ml indicating susceptibility to rabies infection and thereby posing possible threat to surrounding human and animal populations. PMID:26645039

  4. The Effects of Peer-Mediated Check-In/Check-Out on the Social Skills of Socially Neglected Students.

    Science.gov (United States)

    Collins, Tai A; Gresham, Frank M; Dart, Evan H

    2016-07-01

    Check-In/Check-Out (CICO) is a moderately effective Tier 2 intervention often used to address attention-maintained problem behaviors in schools. Recent studies on CICO have demonstrated the effectiveness of the intervention when combined with social skills training and when utilizing students' peers as interventionists. Using a concurrent multiple baseline across participants design, the present study evaluated the effectiveness of peer-mediated CICO to target social skills in elementary school students identified as socially neglected using a sociometric classification system. Results, implications for practice, limitations, and future directions are discussed. PMID:27056878

  5. Radiolabeled antibodies as imaging agents

    International Nuclear Information System (INIS)

    The author gives a survey of the progress made on radioimmunodetection. Antibodies may now be more readily used in scintigraphy as a result of the development of labeling methods that apply more suitable radionuclides without significant loss of the antigen-binding activity. Antibodies to tumor-specific or tumor-associated antigens can now be produced in large quantities by monoclonal antibody technology

  6. Preservation Health Check: Monitoring Threats to Digital Repository Content

    Science.gov (United States)

    Kool, Wouter; van der Werf, Titia; Lavoie, Brian

    2014-01-01

    The Preservation Health Check (PHC) project, undertaken as a joint effort by Open Planets Foundation (OPF) and OCLC Research, aims to evaluate the usefulness of the preservation metadata created and maintained by operational repositories for assessing basic preservation properties. The PHC project seeks to develop an implementable logic to support…

  7. Spanish Language Versions of the Depression Adjective Check Lists.

    Science.gov (United States)

    Lubin, Bernard; And Others

    1980-01-01

    The study aimed to develop an instrument that could be used for mental health research with Spanish-speaking populations. The Depression Adjective Check Lists (DACL) used to measure depressive mood was translated into Spanish and administered to 70 Hispanic subjects. Reliability determinations were high and close to those for the English version.…

  8. Checking the odd Goldbach conjecture up to 10(20)

    Science.gov (United States)

    Saouter, Y.

    1998-04-01

    Vinogradov's theorem states that any sufficiently large odd integer is the sum of three prime numbers. This theorem allows us to suppose the conjecture that this is true for all odd integers. In this paper, we describe the implementation of an algorithm which allowed us to-check this conjecture up to 10(20).

  9. 76 FR 16861 - Availability of Funds and Collection of Checks

    Science.gov (United States)

    2011-03-25

    ... checks to depositary banks electronically.\\8\\ Based on information from banking industry sources, the... of the rule.\\20\\ \\18\\ 57 FR 46956 (Oct. 14, 1992). \\19\\ Times are stated as local time of the paying... is applicable to the Reserve Banks. (53 FR 11911 (Apr. 11, 1988)) The overwhelming majority...

  10. Two Types of Test Assembly Checked and Accepted for CEFR

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The detail design of two types of test assembly used in the simulating transportation, and themounting and hydraulic test were completed in 2002. This two types of test assembly are manufactured inshanghai No.1 machine tool works, and checked and accepted in March 2003. The former is used in the

  11. Homeland Security Initiatives and Background Checks in Higher Education

    Science.gov (United States)

    Hughes, Stephanie; Keller, Eileen Weisenbach; Hertz, Giles T.

    2010-01-01

    In recent years, colleges and universities have faced a new challenge. While there has been a movement underway on college campuses to increase the safety of a wide range of university constituents through criminal background checks (CBCs), in most cases this movement has failed to include CBCs of foreign faculty and student populations. The…

  12. Self-checking state machine realization in CMOS

    Science.gov (United States)

    Lala, P. K.; Walker, A.

    1994-12-01

    In this reporting period we have accomplished the following: (1) developed a procedure for totally self-checking (TSC) checker design for m-out-of-2m codes at the transistor level and (2) derived a technique for designing TSC fault-tolerant systems.

  13. Modelling Chinese Smart Grid : A stochastic model checking case study

    Energy Technology Data Exchange (ETDEWEB)

    Yuksel, E.; Nielson, H.R.; Nielson, F. (Technical Univ. of Denmark. DTU Informatics, Kgs. Lyngby (Denmark)); Zhu, H. (East China Normal Univ. (China)); Huang, H. (Wuxi SensingNet Industrialization Research Institute (China))

    2012-07-01

    In this document, we consider a specific Chinese Smart Grid implementation and try to address the verification problem for certain quantitative properties including performance and battery consumption. We employ stochastic model checking approach and present our modelling and analysis study using PRISM model checker. (Author)

  14. A Standardization of the Mooney Problem Check List - College Form.

    Science.gov (United States)

    Dreger, Ralph Mason; And Others

    The Mooney Problem Check List, College Form, was administered to 2,261 students from six Louisiana universities, for standardization purposes. Usable protocols were obtained for 1,929 subjects. Comparisons among schools, school classes, sex, race, and marital status were made for the 11 Mooney categories. Norm tables were developed for all groups…

  15. Mandatory Identification Bar Checks: How Bouncers Are Doing Their Job

    Science.gov (United States)

    Monk-Turner, Elizabeth; Allen, John; Casten, John; Cowling, Catherine; Gray, Charles; Guhr, David; Hoofnagle, Kara; Huffman, Jessica; Mina, Moises; Moore, Brian

    2011-01-01

    The behavior of bouncers at on site establishments that served alcohol was observed. Our aim was to better understand how bouncers went about their job when the bar had a mandatory policy to check identification of all customers. Utilizing an ethnographic decision model, we found that bouncers were significantly more likely to card customers that…

  16. Bounded Model Checking of Temporal Formulas with Alloy

    OpenAIRE

    Cunha, Alcino

    2012-01-01

    Alloy is formal modeling language based on first-order relational logic, with no specific support for specifying reactive systems. We propose the usage of temporal logic to specify such systems, and show how bounded model checking can be performed with the Alloy Analyzer.

  17. Periodical check of the NPP Dukovany fuel cycles safety

    International Nuclear Information System (INIS)

    Safety analyses are among the most important parts of Safety Analysis Reports (SARs). The analyses are based, among other things, on reactor core characteristics that can change due to fuel burnup or can vary in dependence on the actual fuel cycle design (fuel composition and core design) or other operational conditions. The validity of the SAR must be preserved under all circumstances. This is why elaboration of a methodology for checking the core characteristics was necessary. This concerns especially those core characteristics that can undergo major changes during operation and play an important role in safety analysis. Evaluation of validity of the results of a safety analysis is vital for application of such methodology. The main methodological principles are summarized and some illustrative results for Dukovany NPP units are presented. The following aspects are discussed: History and goals of fuel cycle key parameters checking; Basic principles of methodology (key reactor core parameters for safety analyses: reactivity coefficients and kinetic parameters, efficiency of control assemblies, reactor core power distribution characteristics, combination of parameters for specific events; structure of representative values for safety analyses); Illustration of present state in application of the checking procedure; Possible consequences of the checking procedure application; and Future of the methodology. (P.A.)

  18. A review of historical check valve failure data

    International Nuclear Information System (INIS)

    Check valve operating problems in recent years have resulted in significant operating transients, increased cost, and decreased system availability. In response, additional attention has been given to check valves by utilities, as well as the US Nuclear Regulatory Commission (NRC) and the American Society of Mechanical Engineers Operation and Maintenance Committee. All these organizations have the fundamental goal of ensuring reliable operation of check valves. A key ingredient of an engineering-oriented reliability improvement effort is a thorough understanding of relevant historical experience. Oak Ridge National Laboratory is currently conducting a detailed review of historical failure data available through the Institute of Nuclear Power Operation's Nuclear Plant Reliability Data System. The focus of the review is on check valve failures that have involved significant degradation of the valve internal parts. A variety of parameters are being considered during the review, including size, age, system of service, method of failure discovery, the affected valve parts, attributed causes, and corrective actions. This work is being carried out under the auspices of the NRC's Nuclear Plant Aging Research program. At this time, the study is approximately 50% complete. All failure records have been reviewed and categorized, and preliminary tabulation and correlation of data is underway. The bulk of the tabulation and correlation portion of the work is expected to be completed by the end of June 1992. A report draft is expected in the fall of 1992

  19. Towards Model Checking a Spi-Calculus Dialect

    NARCIS (Netherlands)

    Gnesi, S.; Latella, D.; Lenzini, G.

    2002-01-01

    We present a model checking framework for a spi-calculus dialect which uses a linear time temporal logic for expressing security properties. We have provided our spi-calculus dialect, called SPID, with a semantics based on labeled transition systems (LTS), where the intruder is modeled in the Dolev-

  20. Using Model Checking for Analyzing Distributed Power Control Problems

    DEFF Research Database (Denmark)

    Brihaye, Thomas; Jungers, Marc; Lasaulce, Samson; Markey, Nicolas; Oreiby, Ghassan

    2010-01-01

    Model checking (MC) is a formal verification technique which has been known and still knows a resounding success in the computer science community. Realizing that the distributed power control ( PC) problem can be modeled by a timed game between a given transmitter and its environment, the authors...

  1. 31 CFR 240.14 - Checks issued to incompetent payees.

    Science.gov (United States)

    2010-07-01

    ...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE INDORSEMENT AND PAYMENT OF CHECKS... without submission of documentary proof of the authority of the guardian or other fiduciary, with the... the certifying agency with information as to the incompetence of the payee and documentary...

  2. Model checking conditional CSL for continuous-time Markov chains

    DEFF Research Database (Denmark)

    Gao, Yang; Xu, Ming; Zhan, Naijun;

    2013-01-01

    probabilistic operator. CCSL allows us to express a richer class of properties for CTMCs. Based on a parameterized product obtained from the CTMC and an automaton extracted from a given CCSL formula, we propose an approximate model checking algorithm and analyse its complexity....

  3. Operational workforce planning for check-in counters at airports

    DEFF Research Database (Denmark)

    Stolletz, Raik

    2010-01-01

    This paper addresses operation models for workforce planning for check-in systems at airports. We characterize different tasks of the hierarchical workforce planning problem with time-dependent demand. A binary linear programming formulation is developed for the fortnightly tour scheduling problem...

  4. 40 CFR 91.319 - NOX converter check.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false NOX converter check. 91.319 Section 91...) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Emission Test Equipment Provisions § 91.319 NOX... of the NO concentration). The NOX analyzer must be in the NO mode so that the span gas does not...

  5. Modeling Environment for Component Model Checking from Hierarchical Architecture

    Czech Academy of Sciences Publication Activity Database

    Pařízek, P.; Plášil, František

    2007-01-01

    Roč. 182, - (2007), s. 139-153. ISSN 1571-0661 R&D Projects: GA ČR GA201/06/0770 Institutional research plan: CEZ:AV0Z10300504 Keywords : software components * behavior protocols * environment model checking * hierarchical component architecture Subject RIV: JC - Computer Hardware ; Software

  6. Antibody mimetics: promising complementary agents to animal-sourced antibodies.

    Science.gov (United States)

    Baloch, Abdul Rasheed; Baloch, Abdul Wahid; Sutton, Brian J; Zhang, Xiaoying

    2016-01-01

    Despite their wide use as therapeutic, diagnostic and detection agents, the limitations of polyclonal and monoclonal antibodies have inspired scientists to design the next generation biomedical agents, so-called antibody mimetics that offer many advantages over conventional antibodies. Antibody mimetics can be constructed by protein-directed evolution or fusion of complementarity-determining regions through intervening framework regions. Substantial progress in exploiting human, butterfly (Pieris brassicae) and bacterial systems to design and select mimetics using display technologies has been made in the past 10 years, and one of these mimetics [Kalbitor® (Dyax)] has made its way to market. Many challenges lie ahead to develop mimetics for various biomedical applications, especially those for which conventional antibodies are ineffective, and this review describes the current characteristics, construction and applications of antibody mimetics compared to animal-sourced antibodies. The possible limitations of mimetics and future perspectives are also discussed. PMID:25264572

  7. 47 CFR 80.293 - Check bearings by authorized ship personnel.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Check bearings by authorized ship personnel. 80... Check bearings by authorized ship personnel. The requirement for calibration by check bearings is met if: (a) The required verification by check bearings are made not more than 90 days prior to the date...

  8. Monoclonal antibodies to Pneumocystis carinii

    DEFF Research Database (Denmark)

    Kovacs, J A; Halpern, J L; Lundgren, B; Swan, J C; Parrillo, J E; Masur, H

    1989-01-01

    To increase understanding of the antigenic structure of Pneumocystis carinii, we developed monoclonal antibodies to rat and human P. carinii. The specificity of the antibodies was demonstrated by immunofluorescence and immunoblot studies. Only one of five monoclonal antibodies to rat P. carinii...... reacted with human P. carinii, and none of four monoclonal antibodies to human P. carinii reacted with rat P. carinii. Two antibodies to human P. carinii reacted by immunofluorescence with only one human P. carinii isolate. Immunoblot studies identified major antigens of rat P. carinii with molecular...

  9. [Antibody therapy for Alzheimer's disease].

    Science.gov (United States)

    Tabira, Takeshi; Matsumoto, Shin-Ei; Jin, Haifeng

    2011-11-01

    In order to avoid Abeta-induced autoimmune encephalitis, several monoclonal and polyclonal antibodies are in clinical trials. These are bapineuzumab, solanezumab, ponezumab, gantenerumab, BAN2401, gammaguard and octagam. Since each antibody has a different antigen epitope of Abeta, anti-amyloid activities are different. It is unknown which antibody is effective for Alzheimer disease, and we must wait for the result of clinical trials. Some patients who developed tissue amyloid plaque immuno-reactive (TAPIR) antibody showed slower decline after AN-1792 vaccination. We developed TAPIR-like monoclonal antibody, which was found to react with Abeta oligomers preferentially. PMID:22277519

  10. Tabhu: tools for antibody humanization

    DEFF Research Database (Denmark)

    Olimpieri, Pier Paolo; Marcatili, Paolo; Tramontano, Anna

    2015-01-01

    and time-consuming experiments. Here we present tools for antibody humanization (Tabhu) a web server for antibody humanization. Tabhu includes tools for human template selection, grafting, back-mutation evaluation, antibody modelling and structural analysis, helping the user in all the critical steps......Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to recognize their cognate antigens with high specificity and affinity, and a high yield at reasonable costs in model animals. Unfortunately, when administered to human patients, xenogeneic antibodies can...

  11. Recommended Screening-Checks for Placed Orders in Industry Internal Tool- OMS

    Directory of Open Access Journals (Sweden)

    Niranjanamurthy M

    2014-07-01

    Full Text Available This paper gives the information and proposed solution regarding Screening Checks for Industry Internal Tool-Order Management System. After placing orders by customers through shopping website the industry people should verify the orders in different ways to avoid loss. Need to do Screening and in different checks for Maximize acceptance of valid orders, Increase customer service productivity, More tailored and effective screening strategies, Minimize online fraud losses. Free up your teams to focus on their core competency – running your business. Here mainly proposing screening checks sectors are Credit card information checks, Basic Information checks, financing information checks, Electronic information checks.

  12. Antibody induction versus corticosteroid induction for liver transplant recipients

    DEFF Research Database (Denmark)

    Penninga, Luit; Wettergren, André; Wilson, Colin H;

    2014-01-01

    . OBJECTIVES: To assess the benefits and harms of T-cell specific antibody induction versus corticosteroid induction for prevention of acute rejection in liver transplant recipients. SEARCH METHODS: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of...... Controlled Trials (CENTRAL), MEDLINE, EMBASE, Science Citation Index Expanded, and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) on 30 September 2013 together with reference checking, citation searching, contact with trial authors and pharmaceutical companies to...... identify additional trials. SELECTION CRITERIA: We included all randomised clinical trials assessing immunosuppression with T-cell specific antibody induction versus corticosteroid induction in liver transplant recipients. Our inclusion criteria stated that participants within each included trial should...

  13. Monoclonal antibody as radiopharmaceutical

    International Nuclear Information System (INIS)

    The purification of anti-CEA monoclonal antibody 4C11 belonging to IgG sub(2a) subclass from mouse ascitis, donated by Ludwig Institute, Brazil was developed. The fragmentation of purified IgG sub(2a) by pepsin digestion and analytical studies by polyacrilamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS-PAGE) were done as preliminary assessment for their specific application in immunoscintigraphy. (author)

  14. Anticardiolipin antibodies in leptospirosis.

    OpenAIRE

    Rugman, F P; Pinn, G.; Palmer, M. F.; Waite, M.; Hay, C. R.

    1991-01-01

    The clinical course and serology of 16 cases of leptospirosis in an area with an unusually high endemic infection rate were studied to gain further insight into the pathology of the secondary immune phase that is typical of the disease. IgG anticardiolipin antibody concentrations were measured by immunoassay and found to be increased in eight serologically confirmed cases with severe complicated disease, compared with eight patients with relatively uncomplicated leptospirosis who had IgG anti...

  15. A monoclonal antibody against leptin.

    Science.gov (United States)

    Mahmoudian, Jafar; Jeddi-Tehrani, Mahmood; Bayat, Ali Ahmad; Mahmoudi, Ahmad Reza; Vojgani, Yasaman; Tavangar, Banafsheh; Hadavi, Reza; Zarei, Saeed

    2012-10-01

    Leptin is an important protein that regulates energy storage and homeostasis in humans and animals. Leptin deficiency results in various abnormalities such as diabetes, obesity, and infertility. Producing a high affinity monoclonal antibody against human leptin provides an important tool to monitor and trace leptin function in different biological fluids. In this study, recombinant human leptin was conjugated to KLH and injected into mice. After immunization, mouse myeloma SP2/0 cells were fused with murine splenocytes followed by selection of antibody-producing hybridoma cells. After screening of different hybridoma colonies by ELISA, a high affinity antibody was selected and purified by affinity chromatography. The affinity constant of the antibody was measured by ELISA. Western blot, immunocytochemistry, and flow cytometry experiments were used to characterize the antibody. The anti-leptin antibody had a high affinity (around 1.13 × 10(-9) M) for its antigen. The saturation of the antibody with leptin (20 moles leptin per 1 mole antibody) in Western blot analysis proved that the antibody had specific binding to its antigen. Immunocytochemistry and flow cytometry on JEG-3 (human placental choriocarcinoma cell) cells revealed that the anti-leptin antibody recognized intracellular leptin. In conclusion, we report here the production and characterization of a murine anti-leptin antibody with high affinity for human leptin. PMID:23098305

  16. Antiphospholipid Antibody and Antiphospholipid Syndrome

    Institute of Scientific and Technical Information of China (English)

    吴竞生

    2008-01-01

    @@ Antiphospholipid antibodies (APA) APA is a big category for all kinds of negative charge phospholipid or lecithin - a protein complex autoantibodies or the same antibody, through its recognition of antigen (target protein) different, and phospholipids or lecithin - protein complex combination of various rely on the interference Phospholipid clotting and anti-coagulation factor, and promote endothelial cells, platelets, complement activation and play a role. APA including lupus anticoagulant(LA) and anticardiolipin antibody (ACA), In addition, there are anti-β2 glycoprotein-I (β2-GPI) antibody, anti-prothrombin (a- PT) antibody, anti-lysophosphatidic acid antibody and anti-phosphatidylserine antibody, and so on. APA as the main target of phospholipid-binding protein, including β2-GPI, prothrombin, annexin, protein C (PC) and protein S (PS), plasminogen, and so on.

  17. Antibody therapy for Ebola

    Science.gov (United States)

    Qiu, Xiangguo; Kobinger, Gary P

    2014-01-01

    Ebola viruses can cause severe hemorrhagic fever in humans and nonhuman primates with fatality rates up to 90%, and are identified as biosafety level 4 pathogens and CDC Category A Agents of Bioterrorism. To date, there are no approved therapies and vaccines available to treat these infections. Antibody therapy was estimated to be an effective and powerful treatment strategy against infectious pathogens in the late 19th, early 20th centuries but has fallen short to meet expectations to widely combat infectious diseases. Passive immunization for Ebola virus was successful in 2012, after over 15 years of failed attempts leading to skepticism that the approach would ever be of potential benefit. Currently, monoclonal antibody (mAbs)-based therapies are the most efficient at reversing the progression of a lethal Ebola virus infection in nonhuman primates, which recapitulate the human disease with the highest similarity. Novel combinations of mAbs can even fully cure lethally infected animals after clinical symptoms and circulating virus have been detected, days into the infection. These new developments have reopened the door for using antibody-based therapies for filovirus infections. Furthermore, they are reigniting hope that these strategies will contribute to better control the spread of other infectious agents and provide new tools against infectious diseases. PMID:24503566

  18. Check dams effects on sediment transport in steep slope flume

    Science.gov (United States)

    Piton, Guillaume; Recking, Alain

    2014-05-01

    Depending on many influences (geology, relief, hydrology, land use, etc.) some mountainous watershed are prone to cause casualties and facilities damages. Large amounts of sediments episodically released by torrents are often the biggest problem in torrent related hazard mitigation. Series of transversal structures as check dams and ground sills are often used in the panel of risk mitigation technics. A large literature exits on check dams and it mainly concerns engineering design, e.g. toe scouring, stability stress diagram, changes in upper and lower reaches equilibrium slopes. Check dams in steep slope rivers constitute fixed points in the bed profile and prevent general bed incision. However their influence on sediment transport once they are filled is not yet clear. Two flume test campaigns, synthetize in Table 1, were performed to investigate this question: Table 1 : experiment plan Run (duration) Ref1 (50h)CD1a (30h)CD1b (30h)Ref2 (92h)CD2 (18h) Solid feeding discharge (g.s^-1) 44 44 44 60 60 Number of check dams none 1 3 none 2 A nearly 5-m-long, 10-cm-wide and 12%-steep flume was used. The water discharge was set to 0,55 l/s in all runs. A mixture of poorly sorted natural sediments with diameters between 0.8 and 40 mm was used. An open solid-discharge-feeding circuit kept the inlet sediment flux constant during all experiments. As both feeding rates did not present variation, changes in outlet solid discharge were assumed to be due to bed variations in the bed storage. We observed strong fluctuations of solid flux and slope in each reaches of all runs between: (i) steep aggradating armoured bed and (ii) less steep and finer bed releasing bedload sheets during erosion events and inducing bedload pulses. All experiments showed consistent results: transported volume associated with erosion event decreased with the length between two subsequent check dams. Solid transversal structures shorten the upstream erosion-propagation and avoid downstream change in the

  19. Non-trivial checks of novel consistency relations

    International Nuclear Information System (INIS)

    Single-field perturbations satisfy an infinite number of consistency relations constraining the squeezed limit of correlation functions at each order in the soft momentum. These can be understood as Ward identities for an infinite set of residual global symmetries, or equivalently as Slavnov-Taylor identities for spatial diffeomorphisms. In this paper, we perform a number of novel, non-trivial checks of the identities in the context of single field inflationary models with arbitrary sound speed. We focus for concreteness on identities involving 3-point functions with a soft external mode, and consider all possible scalar and tensor combinations for the hard-momentum modes. In all these cases, we check the consistency relations up to and including cubic order in the soft momentum. For this purpose, we compute for the first time the 3-point functions involving 2 scalars and 1 tensor, as well as 2 tensors and 1 scalar, for arbitrary sound speed

  20. Immune Check Point Inhibitors Combination in Melanoma: Worth the Toxicity?

    Science.gov (United States)

    Orloff, Marlana; Weight, Ryan; Valsecchi, Matias E; Sato, Takami

    2016-01-01

    The combination of immune checkpoint inhibitors ipilimumab and nivolumab has been recently been FDA approved for first line treatment of unresectable and metastatic BRAF wild type melanoma. The approval came following the impressive results of the CheckMate 067, where the combination of ipilimumab and nivolumab appeared to outperform each as a single agent in regards to response rate and progression free survival. Though we await final overall survival data, the combination will likely be adapted by many oncologists and integrated into the ever changing melanoma treatment algorithm. In this article we aim to summarize the data leading up to the recent FDA approval and publication by Larkin et al. that presents the results from the CheckMate 067 trial. We will also further explore the feasibility, challenges, and applicability of combination immune checkpoint inhibitor therapy. PMID:27028970

  1. Application of acoustic emission technique for check valve monitoring

    International Nuclear Information System (INIS)

    Very limited choice is available in monitoring the health of check valves during service. Ultrasonics, magnetic flux leakage and acoustic emission (AE) monitoring are three methods, of which AE is the prominent. The paper describes work done on swing check valves in the ECCS circuit of Cirus using AE. It indicates that the valves can be monitored for any abnormal behaviour during their stable operation and during opening and closing. AE can also sense any abnormality at the hinge pin, hinge arm, disc etc., if they give AE emission. However, many of these may require background data from a spare valve of similar design or a working stand by. In absence of such a valve, data from the present study will be used as a baseline data for comparison with signatures taken during future inspections. (author). 3 refs., 5 figs., 1 tab

  2. Schedulability of Herschel revisited using statistical model checking

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Legay, Axel;

    2015-01-01

    Schedulability analysis is a main concern for several embedded applications due to their safety-critical nature. The classical method of response time analysis provides an efficient technique used in industrial practice. However, the method is based on conservative assumptions related to execution...... and blocking times of tasks. Consequently, the method may falsely declare deadline violations that will never occur during execution. This paper is a continuation of previous work of the authors in applying extended timed automata model checking (using the tool UPPAAL) to obtain more exact...... schedulability analysis, here in the presence of non-deterministic computation times of tasks given by intervals [BCET,WCET]. Computation intervals with preemptive schedulers make the schedulability analysis of the resulting task model undecidable. Our contribution is to propose a combination of model checking...

  3. Mixed Portmanteau Test for Diagnostic Checking of Time Series Models

    Directory of Open Access Journals (Sweden)

    Sohail Chand

    2014-01-01

    Full Text Available Model criticism is an important stage of model building and thus goodness of fit tests provides a set of tools for diagnostic checking of the fitted model. Several tests are suggested in literature for diagnostic checking. These tests use autocorrelation or partial autocorrelation in the residuals to criticize the adequacy of fitted model. The main idea underlying these portmanteau tests is to identify if there is any dependence structure which is yet unexplained by the fitted model. In this paper, we suggest mixed portmanteau tests based on autocorrelation and partial autocorrelation functions of the residuals. We derived the asymptotic distribution of the mixture test and studied its size and power using Monte Carlo simulations.

  4. Asymptomatic brain tumor detected at brain check-up

    Energy Technology Data Exchange (ETDEWEB)

    Onizuka, Masanari; Suyama, Kazuhiko; Shibayama, Akira; Hiura, Tsuyoshi; Horie, Nobutaka; Miyazaki, Hisaya [Sankoukai Miyazaki Hospital, Isahaya, Nagasaki (Japan)

    2001-09-01

    Brain check-up was performed in 4000 healthy subjects who underwent medical and radiological examinations for possible brain diseases in our hospital from April 1996 to March 2000. Magnetic resonance imaging revealed 11 brain tumors which consisted of six meningiomas, three pituitary adenomas, one astrocytoma, and one epidermoid cyst. The detection rate of incidental brain tumor in our hospital was 0.3%. Nine patients underwent surgery, with one case of morbidity due to postoperative transient oculomotor nerve paresis. The widespread use of brain check-up may increasingly detect asymptomatic brain tumors. Surgical indications for such lesions remain unclear, and the strategy for treatment should be determined with consideration of the patient's wishes. (author)

  5. Analysis of DIRAC's behavior using model checking with process algebra

    CERN Document Server

    Remenska, Daniela; Willemse, Tim; Bal, Henri; Verstoep, Kees; Fokkink, Wan; Charpentier, Philippe; Diaz, Ricardo Graciani; Lanciotti, Elisa; Roiser, Stefan; Ciba, Krzysztof

    2012-01-01

    DIRAC is the grid solution developed to support LHCb production activities as well as user data analysis. It consists of distributed services and agents delivering the workload to the grid resources. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check and possibly react to changes in the system state. Each agent's logic is relatively simple, the main complexity lies in their cooperation. Agents run concurrently, and collaborate using the databases as shared memory. The databases can be accessed directly by the agents if running locally or through a DIRAC service interface if necessary. This shared-memory model causes entities to occasionally get into inconsistent states. Tracing and fixing such problems becomes formidable due to the inherent parallelism present. We propose more rigorous methods to cope with this. Model checking is one such technique for analysis of an abstract model of a system. Unlike con...

  6. Detecting feature interactions in Web services with model checking techniques

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    As a platform-independent software system, a Web service is designed to offer interoperability among diverse and heterogeneous applications.With the introduction of service composition in the Web service creation, various message interactions among the atomic services result in a problem resembling the feature interaction problem in the telecommunication area.This article defines the problem as feature interaction in Web services and proposes a model checking-based detection method.In the method, the Web service description is translated to the Promela language - the input language of the model checker simple promela interpreter (SPIN), and the specific properties, expressed as linear temporal logic (LTL) formulas, are formulated according to our classification of feature interaction.Then, SPIN is used to check these specific properties to detect the feature interaction in Web services.

  7. SMT-based Bounded Model Checking with Difference Logic Constraints

    CERN Document Server

    Bersani, Marcello M; Morzenti, Angelo; Pradella, Matteo; Rossi, Matteo; Pietro, Pierluigi San

    2010-01-01

    Traditional Bounded Model Checking (BMC) is based on translating the model checking problem into SAT, the Boolean satisfiability problem. This paper introduces an encoding of Linear Temporal Logic with Past operators (PLTL) into the Quantifier-Free Difference Logic with Uninterpreted Functions (QF-UFIDL). The resulting encoding is a simpler and more concise version of existing SATbased encodings, currently used in BMC. In addition, we present an extension of PLTL augmented with arithmetic relations over integers, which can express unbounded counters; as such, the extended logic is more expressive than PLTL. We introduce suitable restrictions and assumptions that are shown to make the verification problem for the extended logic decidable, and we define an encoding of the new logic into QF-UFIDL. Finally, a performance comparison with the SAT-based approach on purely PLTL examples shows significant improvements in terms of both execution time and memory occupation.

  8. L2C2: Logic-based LSC Consistency Checking

    CERN Document Server

    Guo, Hai-Feng; Subramaniam, Mahadevan

    2010-01-01

    Live sequence charts (LSCs) have been proposed as an inter-object scenario-based specification and visual programming language for reactive systems. In this paper, we introduce a logic-based framework to check the consistency of an LSC specification. An LSC simulator has been implemented in logic programming, utilizing a memoized depth-first search strategy, to show how a reactive system in LSCs would response to a set of external event sequences. A formal notation is defined to specify external event sequences, extending the regular expression with a parallel operator and a testing control. The parallel operator allows interleaved parallel external events to be tested in LSCs simultaneously; while the testing control provides users to a new approach to specify and test certain temporal properties (e.g., CTL formula) in a form of LSC. Our framework further provides either a state transition graph or a failure trace to justify the consistency checking results.

  9. Will online bill payment spell the demise of paper checks?

    OpenAIRE

    James C. McGrath

    2005-01-01

    Over the past several years, the emergence and adoption of electronic payment instruments have acutely affected check usage. This transition has been especially evident at the point of sale as debit and credit cards have become pervasive. Today, the rapid growth of online bill payment looks to threaten checks’ last redoubt. However, bill payment technology is still in its adolescence; the interplay of many stakeholders in the industry, including technology firms, banks, billers, payment cards...

  10. Checking Session-Oriented Interactions between Web Services

    Czech Academy of Sciences Publication Activity Database

    Parízek, P.; Adámek, Jiří

    Los Alamitos: IEEE Computer Society, 2008, s. 3-10. ISBN 978-0-7695-3276-9. [SEAA 2008. EUROMICRO Conference on Software Engineering and Advanced Applications /34./. Parma (IT), 03.09.2008-05.09.2008] R&D Projects: GA AV ČR 1ET400300504 Institutional research plan: CEZ:AV0Z10300504 Keywords : web services * BPEL * session-oriented interactions * behavior protocols * model checking Subject RIV: JC - Computer Hardware ; Software

  11. Fast Liveness Checking for SSA-Form Programs

    OpenAIRE

    Boissinot B.; Hack S.; Grund D.; De Dinechin B.D.; Rastello F.

    2007-01-01

    Liveness analysis is an important analysis in optimizing compilers. Liveness information is used in several optimizations and is mandatory during the code-generation phase. Two drawbacks of conventional liveness analyses are that their computations are fairly expensive and their results are easily invalidated by program transformations. We present a method to check liveness of variables that overcomes both obstacles. The major advantage of the proposed method is that the analysis result survi...

  12. Logic Model Checking of Unintended Acceleration Claims in Toyota Vehicles

    Science.gov (United States)

    Gamble, Ed

    2012-01-01

    Part of the US Department of Transportation investigation of Toyota sudden unintended acceleration (SUA) involved analysis of the throttle control software, JPL Laboratory for Reliable Software applied several techniques including static analysis and logic model checking, to the software; A handful of logic models were build, Some weaknesses were identified; however, no cause for SUA was found; The full NASA report includes numerous other analyses

  13. A Novel Nanometric Reversible Signed Divider with Overflow Checking Capability

    OpenAIRE

    Faraz Dastan; Majid Haghparast

    2012-01-01

    One of the best approaches for designing future computers is that we use reversible logic. Reversible logic circuits have lower power consumption than the common circuits, used in computers nowadays. In this study we propose a new reversible division circuit. This reversible division circuit is signed divider and has an overflow checking capability. Among the designed and proposed reversible division circuits, our proposed division circuit is the first reversible signed divider with overflow ...

  14. Practical Run-time Checking via Unobtrusive Property Caching

    OpenAIRE

    Stulova, Nataliia; Morales, José F.; Hermenegildo, Manuel V.

    2015-01-01

    The use of annotations, referred to as assertions or contracts, to describe program properties for which run-time tests are to be generated, has become frequent in dynamic programing languages. However, the frameworks proposed to support such run-time testing generally incur high time and/or space overheads over standard program execution. We present an approach for reducing this overhead that is based on the use of memoization to cache intermediate results of check evaluation, avoiding repea...

  15. 309 Facility deactivation and decommisioning Criteria Completion Check Lists

    International Nuclear Information System (INIS)

    To facilitate and track completion of the 309 Facility turnover criteria completion an Applicability Matrix and Criteria Completion Check Lists were prepared. The applicability matrix documents the required turnover criteria for a given area in the facility or scope of work. The applicable criteria is selected for 16 different areas. For each area a completion checklist is provided to document completion of a requirement by WHC and the Environmental Restoration Contractor

  16. Building Reusable Software Component For Optimization Check in ABAP Coding

    Directory of Open Access Journals (Sweden)

    P.Shireesha

    2010-07-01

    Full Text Available Software component reuse is the software engineering practice of developing newsoftware products from existing components. A reuse library or component reuserepository organizes stores and manages reusable components. This paper describeshow a reusable component is created, how it reuses the function and checking ifoptimized code is being used in building programs and applications. Finally providingcoding guidelines, standards and best practices used for creating reusable componentsand guidelines and best practices for making configurable and easy to use.

  17. Time-of-flight spectroscopy: energy calibration and consistensy check

    Science.gov (United States)

    Stunault, A.; Andersen, K. H.; Blanc, Y.; Fåk, B.; Godfrin, H.; Guckelsberger, K.; Scherm, R.

    1992-06-01

    A method for calibration of the energy transfers at a time-of-flight (TOF) spectrometer is presented: flight pamths and wavelength are determined to 10 -3 using the arrival times of neutron pulses and prompt capture γs from the sample. We also developed a method to check the reproducibility of a series of TFO data sets, each with over 50 000 data points.

  18. Symbolic Model Checking and Analysis for E-Commerce Protocol

    Institute of Scientific and Technical Information of China (English)

    WEN Jing-Hua; ZHANG Mei; LI Xiang

    2005-01-01

    A new approach is proposed for analyzing non-repudiation and fairness of e-commerce protocols. The authentication e-mail protocol CMP1 is modeled as finite state machine and analyzed in two vital aspects - non-repudiation and fairness using SMV. As a result, the CMP1 protocol is not fair and we have improved it. This result shows that it is effective to analyze and check the new features of e-commerce protocols using SMV model checker

  19. Model Checking Processes Specified In Join-Calculus Algebra

    Directory of Open Access Journals (Sweden)

    Sławomir Piotr Maludziński

    2014-01-01

    Full Text Available This article presents a model checking tool used to verify concurrent systems specified in join-calculus algebra. The temporal properties of systems under verification are expressed in CTL logic. Join-calculus algebra with its operational semantics defined by the chemical abstract machine serves as the basic method for the specification of concurrent systems and their synchronization mechanisms, and allows the examination of more complex systems.

  20. Model Checking Processes Specified In Join-Calculus Algebra

    OpenAIRE

    Sławomir Piotr Maludziński; Grzegorz Dobrowolski

    2014-01-01

    This article presents a model checking tool used to verify concurrent systems specified in join-calculus algebra. The temporal properties of systems under verification are expressed in CTL logic. Join-calculus algebra with its operational semantics defined by the chemical abstract machine serves as the basic method for the specification of concurrent systems and their synchronization mechanisms, and allows the examination of more complex systems.

  1. A Graphical μ-Calculus and Local Model Checking

    Institute of Scientific and Technical Information of China (English)

    林惠民

    2002-01-01

    A graphical notation for the propositionalμ-calculus, called modal graphs, ispresented. It is shown that both the textual and equational presentations of theμ-calculus canbe translated into modal graphs. A model checking algorithm based on such graphs is proposed.The algorithm is truly local in the sense that it only generates the parts of the underlyingsearch space which are necessary for the computation of the final result. The correctness of thealgorithm is proven and its complexity analysed.

  2. Model Checking for Licensing Support in the Finnish Nuclear Industry

    Energy Technology Data Exchange (ETDEWEB)

    Antti, Pakonen; Janne, Valkonen [VTT Technical Research, VTT (Finland); Sami, Matinaho; Markus, Hartikainen [Protum Power and Heat, Fortum (Finland)

    2014-08-15

    This paper examines how model checking can be used to support the qualification of digital I and C software in nuclear power plants, in a way that is consistent with regulatory demands specifically, the common position of seven European nuclear regulators and authorised technical support organisations. As a practical example, we discuss the third-party review service provided by VTT for the power company Fortum in the I and C renewal project of the Loviisa plant in southern Finland.

  3. Feasibility Checking for Dial-a-Ride Problems

    DEFF Research Database (Denmark)

    Haugland, Dag; Ho, Sin C.

    Hunsaker and Savelsbergh have proposed an algorithm for testing feasibility of a route in the solution to the dial-a-ride problem. The constraints that are checked are load capacity constraints, time windows, ride time bounds and wait time bounds. The algorithm has linear running time. By virtue ...... a simple example, we show in this work that their algorithm is incorrect. We also prove that by increasing the time complexity by only a logarithmic factor, a correct algorithm is obtained....

  4. INVESTING FORMULA ENFORCEABLE BILL OF EXCHANGE, PROMISSORY NOTES AND CHECK

    OpenAIRE

    SILVIA - ELENA OLARU

    2011-01-01

    Right bills constituted a proper, solemn and formal training both bills of exchange, promissory notes or checks, but also in terms of bills receivable realization and autonomy is manifested in the sphere of application, and in priority and exclusivity of its incidence from common law, namely the Civil Procedure Code. Legal rules relating to bills of rights realization is a perfect rigorous regime. The special regime, derogating governing procedure execution quality bills is justified and bill...

  5. Parallel State Space Construction for Model-Checking

    OpenAIRE

    Garavel, Hubert; Mateescu, Radu; Smarandache, Irina

    2001-01-01

    The verification of concurrent finite-state systems by model-checking often requires to generate (a large part of) the state space of the system under analysis. Because of the state explosion problem, this may be a resource-consuming operation, both in terms of memory and CPU time. In this report, we aim at improving the performances of state space construction by using parallelization techniques. We present parallel algorithms for constructing state spaces (or Labeled Transition Systems) on ...

  6. Residential Landscape Water Check Programs: Exploring a Conservation Tool

    OpenAIRE

    Glenn, Diana T.

    2010-01-01

    In response to drought and regional growth in the arid western United States, urban water demand management is increasingly important. Single family residences use approximately 60% of their water consumption to irrigate landscapes often in excess of plant water requirements. This study utilized a quasi-experimental design to investigate outdoor water consumption and assess the effectiveness of a landscape water check conservation program. Study objectives included describing a contextualized...

  7. Correctness of Sensor Network Applications by Software Bounded Model Checking

    Science.gov (United States)

    Werner, Frank; Faragó, David

    We investigate the application of the software bounded model checking tool CBMC to the domain of wireless sensor networks (WSNs). We automatically generate a software behavior model from a network protocol (ESAWN) implementation in a WSN development and deployment platform (TinyOS), which is used to rigorously verify the protocol. Our work is a proof of concept that automatic verification of programs of practical size (≈ 21 000 LoC) and complexity is possible with CBMC and can be integrated into TinyOS. The developer can automatically check for pointer dereference and array index out of bound errors. She can also check additional, e.g., functional, properties that she provides by assume- and assert-statements. This experience paper shows that our approach is in general feasible since we managed to verify about half of the properties. We made the verification process scalable in the size of the code by abstraction (eg, from hardware) and by simplification heuristics. The latter also achieved scalability in data type complexity for the properties that were verifiable. The others require technical advancements for complex data types within CBMC's core.

  8. Assembly-line health check up in digitalized hospital.

    Science.gov (United States)

    Liu, Yalan; Yao, Bin; Zhang, Zigang

    2002-01-01

    The health check up flow of digital hospital can be consulted with the assembly line of industry factory. Because they have the following same features: highly specialized workstation, closeness and continuance, rhythm, balanced production, continuous production. The essential prerequisites are as the follows: The inspecting items and methods should be stable; advanced product mix and stable production design; standardized raw material, consumption, procedure, inspection method; there are lots of request for health inspection; the customers move at the least unit; the space arrangement should be reasonable; the time arrangement should be proportion. With the computer net, the digital inspection can achieves the raw material controlling accurately. The basis of check up line concerns about equipment, net and software, data collection, and personnel. The group technology is used in the health inspection flow design of the digital hospital in the field of items customers and zone redivided. The digital assembly linemic health inspect has the following stages: member registering, notice, check in, arrange order, time control, report, feedback and analysis. The assembly linemic has following advantages: increasing the productivity, the space utility, satisfaction of customer, fund returning, lowering the cost and ensuring the quality. PMID:12674786

  9. Assembly-Line Health Check up in Digitalized Hospital

    Institute of Scientific and Technical Information of China (English)

    刘雅兰; 姚斌; 张子刚

    2002-01-01

    Summary: The health check up flow of digital hospital can be consulted with the assembly line ofindustry factory. Because they have the following same features: highly specialized workstation,closeness and continuance, rhythm, balanced production, continuous production. The essentialprerequisites are as the follows: The inspecting items and methods should be stable; advancedproduct mix and stable production design; standardized raw material, consumption, procedure,inspection method; there are lots of request for health inspection; the customers move at the leastunit; the space arrangement should be reasonable; the time arrangement should be proportion.With the computer net, the digital inspection can achieves the raw material controlling accurately.The basis of check up line concerns about equipment, net and software, data collection, and per-sonnel. The group technology is used in the health inspection flow design of the digital hospital inthe field of items customers and zone redivided. The digital assembly linemic health inspect has thefollowing stages: member registering, notice, check in, arrange order, time control, report, feed-back and analysis. The assembly linemic has following advantages: increasing the productivity,the space utility, satisfaction of customer, fund returning, lowering the cost and ensuring thequality.

  10. Improved Trial Division Technique for Primality Checking in RSA Algorithm

    Directory of Open Access Journals (Sweden)

    Kumarjit Banerjee

    2012-07-01

    Full Text Available The RSA cryptosystem, invented by Ron Rivest, Adi Shamir and Len Adleman was first publicized in the August 1977 issue of Scientific American. The security level of this algorithm very much depends on two large prime numbers. To check the primality of large number in personal computer is huge time consuming using the best known trial division algorithm. The time complexity for primality testing has been reduced using the representation of divisors in the form of 6n±1. According to the fundamental theorem of Arithmetic, every number has unique factorization. So to check primality, it is sufficient to check if the number is divisible by any prime below the square root of the number. The set of divisors obtained by 6n±1 form representation contains many composites. These composite numbers have been reduced by 30k approach. In this paper, the number of composites has been further reduced using 210k approach. A performance analysis in time complexity has been given between 210k approach and other prior applied methods. It has been observed that the time complexity for primality testing has been reduced using 210k approach.

  11. SU8 diaphragm micropump with monolithically integrated cantilever check valves.

    Science.gov (United States)

    Ezkerra, Aitor; Fernández, Luis José; Mayora, Kepa; Ruano-López, Jesús Miguel

    2011-10-01

    This paper presents a SU8 unidirectional diaphragm micropump with embedded out-of-plane cantilever check valves. The device represents a reliable and low-cost solution for integration of microfluidic control in lab-on-a-chip devices. Its planar architecture allows monolithic definition of its components in a single step and potential integration with previously reported PCR, electrophoresis and flow-sensing SU8 microdevices. Pneumatic actuation is applied on a PDMS diaphragm, which is bonded to the SU8 body at wafer level, further enhancing its integration and mass production capabilities. The cantilever check valves move synchronously with the diaphragm, feature fast response (10ms), low dead volume (86nl) and a 94% flow blockage up to 300kPa. The micropump achieves a maximum flow rate of 177 μl min(-1) at 6 Hz and 200 kPa with an effective area of 10 mm(2). The device is reliable, self-priming and tolerant to particles and big bubbles. To the knowledge of the authors, this is the first micropump in SU8 with monolithically integrated cantilever check valves. PMID:21853192

  12. Second antibody clearance of radiolabeled antibody in cancer radioimmunodetection.

    OpenAIRE

    Sharkey, R M; Primus, F J; Goldenberg, D. M.

    1984-01-01

    The imaging of tumors using radiolabeled antibodies previously has required the implementation of computer-assisted subtraction techniques to reduce background radioactivity. A decrease in radioactivity in the blood of hamsters bearing human colonic tumor xenografts has been achieved by administering a second antibody directed against a radiolabeled primary antibody to carcinoembryonic antigen (CEA). This method was found to reduce the level of blood radioactivity by a factor of 4 within 2 hr...

  13. Antibody Glossary —

    Science.gov (United States)

    The components of the immune system have diverse roles in the initial development of cancers, progression of early-stage malignancies to invasive tumors, establishment of metastatic lesions, tumor dormancy, and response or resistance to therapy. Characterizing the components of the immune system and their functional status in tissues and in tumors requires the use of highly specific reagents. Researchers employ antibodies in a variety of in vitro and in vivo applications to delineate, enrich, or deplete specific immune subsets in order to understand their role(s) in tumorigenesis. This is a glossary of validated reagents and protocols that are useful for functional phenotyping of the immune system in murine cancer models.

  14. The antibody Hijikata Tatsumi

    Directory of Open Access Journals (Sweden)

    Éden Peretta

    2012-11-01

    Full Text Available Considered one of the most influential modern dance representatives in Japan, Tatsumi Hijikata’s work was a milestone in the Japanese post-war experimental artistic scene. Heretic son of his time, he staged a fertile mix of artistic and cultural influences, overlapping subversive elements of European arts and philosophy with radical references from pre-modern Japanese culture. In this way he built the foundations of its unstable antibody, its political-artistic project of dissolution of a organism, both physical and social.

  15. VIRAL ANTIBODIES IN PRESCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    S. Saidi

    1974-08-01

    Full Text Available One hundred sera from children 1 - 6 years of age, representative of a large serum collection, were tested for the prevalence of antibodies against different viruses. Hemagglutination-inhibition (HI antibodies were found in 68% for measles; 61 % for rubella; 75'% for influenza A2/Hong Kong/68, 16% for influenza B/Md./59, 0% for group A arboviruses, 10% for group B arboviruses, 3% for phlebotomus fever group and 4% for Congo-Crimean hemorrhagic fever (C-CHF group of arboviruses Poliomyelitis-neutralizing antibodies for type 1, 2 and 3 were 90%; 85% and 84%~ respectively. Antibody to EH virus was detected in 84% of the sera by immuno-fluorescence. None of the sera were positive for hepatitis-B antigen or antibody by immuno-precipitation test. The prevalence of some viral antibodies found in this survey are compared with results obtained from surveys in other parts of the country.

  16. Antibodies to watch in 2015

    OpenAIRE

    Reichert, Janice M

    2014-01-01

    The commercial pipeline of recombinant antibody therapeutics is robust and dynamic. As of early December 2014, a total of 6 such products (vedolizumab, siltuximab, ramucirumab, pembrolizumab, nivolumab, blinatumomab) were granted first marketing approvals in 2014. As discussed in this perspective on antibodies in late-stage development, the outlook for additional approvals, potentially still in 2014 and certainly in 2015, is excellent as marketing applications for 6 antibody therapeutics (sec...

  17. Monoclonal antibodies for treating cancer

    International Nuclear Information System (INIS)

    The purpose of this study is to assess the current status of in-vivo use of monoclonal antibodies for treating cancer. Publications appearing between 1980 and 1988 were identified by computer searches using MEDLINE and CANCERLIT, by reviewing the table of contents of recently published journals, and by searching bibliographies of identified books and articles. More than 700 articles, including peer-reviewed articles and book chapters, were identified and selected for analysis. The literature was reviewed and 235 articles were selected as relevant and representative of the current issues and future applications for in-vivo monoclonal antibodies for cancer therapy and of the toxicity and efficacy which has been associated with clinical trials. Approaches include using antibody alone (interacting with complement or effector cells or binding directly with certain cell receptors) and immunoconjugates (antibody coupled to radioisotopes, drugs, toxins, or other biologicals). Most experience has been with murine antibodies. Trials of antibody alone and radiolabeled antibodies have confirmed the feasibility of this approach and the in-vivo trafficking of antibodies to tumor cells. However, tumor cell heterogeneity, lack of cytotoxicity, and the development of human antimouse antibodies have limited clinical efficacy. Although the immunoconjugates are very promising, heterogeneity and the antimouse immune response have hampered this approach as has the additional challenge of chemically or genetically coupling antibody to cytotoxic agents. As a therapeutic modality, monoclonal antibodies are still promising but their general use will be delayed for several years. New approaches using human antibodies and reducing the human antiglobulin response should facilitate treatment. 235 references

  18. Metrics for antibody therapeutics development

    OpenAIRE

    Reichert, Janice M

    2010-01-01

    A wide variety of full-size monoclonal antibodies (mAbs) and therapeutics derived from alternative antibody formats can be produced through genetic and biological engineering techniques. These molecules are now filling the preclinical and clinical pipelines of every major pharmaceutical company and many biotechnology firms. Metrics for the development of antibody therapeutics, including averages for the number of candidates entering clinical study and development phase lengths for mAbs approv...

  19. Empowered Antibody Therapies - IBC conference.

    Science.gov (United States)

    Herold, Jens

    2010-10-01

    The Empowered Antibody Therapies conference, held in Burlingame, CA, USA, included topics covering new therapeutic developments in the field of multispecific antibodies. This conference report highlights selected presentations on DVD-Igs from Abbott Laboratories, ImmTACs from Immunocore, 'Dock-and-Lock' technology from Immunomedics, the bispecific BiTE antibody blinatumomab from Micromet, and Triomabs from TRION Pharma and Fresenius Biotech. PMID:20878591

  20. Check Point瞄准新的市场和方向%Check Point Aims at New Market and New Direction

    Institute of Scientific and Technical Information of China (English)

    白洁

    2007-01-01

    互联网安全解决方案供应商Check Point软件技术有限公司市场运营及技术服务副总裁Amnon Bar-Lev日前来京,他负责Checkpoint产品的全球销售、合作伙伴计划、国际市场营销以及技术服务管理。Bar-Lev表示,中国市场对安全方案的需求日益扩大,已经成为Check Point锁定的4大重点新兴市场之一,此外,该公司今后将以网络安全、数据安全及统一管理架构3个方面,进一步巩固Check Point在安全市场的领导地位。

  1. Antibody informatics for drug discovery

    DEFF Research Database (Denmark)

    Shirai, Hiroki; Prades, Catherine; Vita, Randi;

    2014-01-01

    infrastructure for these large data sets has become necessary. In this article, we first identify and discuss the typical obstacles faced during the antibody drug discovery process. We then summarize the current status of three sub-fields of antibody informatics as follows: (i) recent progress in technologies...... (iii) antibody numbering and IMGT. Here, we review “antibody informatics,” which may integrate the above three fields so that bridging the gaps between industrial needs and academic solutions can be accelerated. This article is part of a Special Issue entitled: Recent advances in molecular engineering...

  2. Tumor imaging with monoclonal antibodies

    International Nuclear Information System (INIS)

    Many monoclonal antibodies directed against tumor-associated antigens have been identified, but so far none of these are tumor specific. Polyclonal and monoclonal antibodies have been used for imaging of a wide variety of tumors with success. Radiolabeling of antibody is usually done with iodine isotopes of which 123I is the best candidate for radioimmunodetection purposes. The labeling of antibodies through chelates makes it possible to use metal radioisotopes like 111In, which is the best radioisotope for imaging with monoclonal antibodies due to its favorable half-life of 2.5 days. Usually imaging cannot be performed within 24 h after injection, but clearance of antibody can be increased by using F(ab)2 of Fab. Another approach is to clear non-bound antibody by a second antibody, directed against the first. The detection limit of immunoimaging is about 2 cm, but will be improved by tomography or SPECT. There is still a high false positive and false negative rate, which makes it impossible to use radioimmunodetection as the only technique for diagnosis of tumors. In combination with other detection techniques, tumor imaging with monoclonal antibodies can improve diagnosis. 44 refs.; 3 tabs

  3. Creating Ordered Antibody Arrays with Antibody-Polymer Conjugates

    Science.gov (United States)

    Dong, Xuehui; Obermeyer, Allie; Olsen, Bradley

    Antibodies are a category of functional proteins that play crucial roles in the immune system and have been widely applied in the area of cancer therapeutics, targeting delivery, signal detection, and sensors. Due to the extremely large size and lack of specific functional groups on the surface, it is challenging to functionalize antibodies and manipulate the ordered packing of antibodies in an array with high density and proper orientation, which is critical to achieve outstanding performance in materials. In this work, we demonstrate an efficient and facile approach for preparing antibody-polymer conjugates with two-step sequential ``click'' reaction to form antibody-polymer block copolymers. Highly ordered nanostructures are fabricated based on the principles of block copolymer self-assembly. The nanostructures are studied with both small angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). Lamellae with alternating antibody domain and polymer domain are observed with an overall domain size of ~50 nm. The nanostructure not only increases the packing density and promotes proper orientation of the antibody, but also provides possible channel to facilitate substrate transportation and improves the stability of the antibody.

  4. Purification of anti-bromelain antibodies by affinity precipitation using pNIPAm-linked bromelain.

    Science.gov (United States)

    Mahmood, Rubab

    2016-01-01

    Affinity precipitation has emerged as a very useful technique for the purification of proteins. Here it has been employed for the purification of anti-bromelain antibodies from rabbit serum. A system has been developed for reversibly binding and thermoprecipitating antibodies. Anti-bromelain antibodies were raised in rabbit by immunizing it with bromelain. Poly-N-isopropylacrylamide (pNIPAm)-bromelain conjugate was prepared and incubated with rabbit serum. After that the temperature was raised for thermal precipitation of the polymer. Antibodies were then eluted from the complex by incubating it with a small volume of buffer, pH 3.0. This method is very effective in concentrating the antibodies. Purity and specificity of the antibodies were checked by gel electrophoresis and enzyme-linked immunosorbent assay (ELISA), respectively. The study of the effect of pH and temperature on the binding of the antibodies to the conjugate showed that the optimum binding occurred at pH 8.0 and 25°C.The polymer enzyme conjugate was further used for another cycle. PMID:25569629

  5. A magnetically driven PDMS micropump with ball check-valves

    Science.gov (United States)

    Pan, Tingrui; McDonald, Scott J.; Kai, Eleanor M.; Ziaie, Babak

    2005-05-01

    In this paper, we present a low-cost, PDMS-membrane micropump with two one-way ball check-valves for lab-on-a-chip and microfluidic applications. The micropump consists of two functional PDMS layers, one holding the ball check-valves and an actuating chamber, and the other covering the chamber and holding a miniature permanent magnet on top for actuation. An additional PDMS layer is used to cover the top magnet, and thereby encapsulate the entire device. A simple approach was used to assemble a high-performance ball check-valve using a micropipette and heat shrink tubing. The micropump can be driven by an external magnetic force provided by another permanent magnet or an integrated coil. In the first driving scheme, a small dc motor (6 mm in diameter and 15 mm in length) with a neodymium-iron-boron permanent magnet embedded in its shaft was used to actuate the membrane-mounted magnet. This driving method yielded a large pumping rate with very low power consumption. A maximum pumping rate of 774 µL min-1 for deionized water was achieved at the input power of 13 mW, the highest pumping rate reported in the literature for micropumps at such power consumptions. Alternatively, we actuated the micropump with a 10-turn planar coil fabricated on a PC board. This method resulted in a higher pumping rate of 1 mL min-1 for deionized water. Although more integratable and compact, the planar microcoil driving technique has a much higher power consumption.

  6. Functional consistency checking module for signal validation: Topical report

    International Nuclear Information System (INIS)

    This report discusses the basic principles of a functional consistency checking module for signal validation in nuclear plants. This module will add additional features to the signal validation system currently being designed at the University of Tennessee. The goals of the functional consistency module are to provide solutions to the common mode features and single or dual sensor failures. The basic principle lies in the comparison of the actual outputs and outputs derived from reference static or dynamics models. The only requirement needed for this method is that the plant must be decomposed into subsystems with observable inputs and outputs. The reference models can be either empirical or derived from physical laws. The main feature of this module is its capability to separate component failures from sensor failures. The failures which can be isolated are bias, drifts, absormal noise or changes in the dynamic sensor characteristics. The decision-making process relies basically on truth table look-up. The truth table contents are derived from an apriori knowledge of the failure causes. More elaborate decision making processes based on pattern recognition techniques or expert systems are proposed to improve the reliability of the decisions. A modified sequential probability ratio test is suggested to handle adequately the modeling errors. The proposed functional consistency checking is valid for both steady state and transient conditions. In the latter case, the transfer functions of the instrumentation channels must be taken into account for a fast and accurate failure identification. To conclude the report, anticipated benefits of the functional consistency checking are listed

  7. Mobile Attendance Checking System on Android Platform for Kazakhstani University

    Science.gov (United States)

    Saparkhojayev, N.; Shakhov, E.; Mailybayev, Y.

    2016-04-01

    In the 21st century-the century of Information Technology, it is difficult to imagine life without any gadgets: phones, tablets, computers, laptops, and so on. Today, smartphones and tablets are becoming popular, and thus their operating systems become popular too. Android is designed for low-power devices that run on battery power at full capacity, using all of its services, such as cameras, lights, GPS navigation, Wi-Fi, etc. In Kazakhstani universities, the process of checking students’ attendance is one of the important issues, because final grade evaluation of students is based on their total number of appearances and their grades during the whole semester. This raises the question of having some tool to control students’ attendance. There are many possible ways of controlling attendance: there are many examples when universities prefer to control attendance by the use of paper sheet, and some universities prefer to use two-stage way of controlling attendance: firstly, teachers and professors use paper sheet for checking students’ attendance and after this, they fill out these information into a system manually. However, this is not an efficient way since there will be spent much of time for calling students names and putting marks like “presence” or “absence” if the class is a lecture class, and in this class at least 5 groups are presented. Furthermore, some students may call his/her friend as “presence” nevertheless to the fact that this student is currently absent. After taking into consideration all these issues and the fact that many gadgets use Android platform, authors of the following research paper decided to create a mobile system that makes easier to check students’ attendance automatically, and this system is implemented in Almaty Management University, Kazakhstan. The system is based on Android platform, and in this paper, details of this system are presented.

  8. Astronaut Charles Conrad checks out Human Vestibular Function experiment

    Science.gov (United States)

    1973-01-01

    Astronaut Charles Conrad Jr., commander of the first manned Skylab mission, checks out the Human Vestibular Function, Experiment M131, during Skylab training at JSC. Conrad is in the work and experiments compartment of the crew quarters of the Skylab Orbital Workshop (OWS) trainer at JSC. The reference sphere with a magnetic rod is used by the astronaut to indicate body orientation non-visually. The litter chair in which he is seated can be rotated by a motor at its base or, when not being rotated, can tilt forward, backward or to either side.

  9. Model-Checking Linear-Time Properties of Quantum Systems

    CERN Document Server

    Ying, Mingsheng; Yu, Nengkun; Feng, Yuan

    2011-01-01

    We define a formal framework for reasoning about linear-time properties of quantum systems in which quantum automata are employed in the modeling of systems and certain closed subspaces of state (Hilbert) spaces are used as the atomic propositions about the behavior of systems. We provide an algorithm for verifying invariants of quantum automata. Then automata-based model-checking technique is generalized for the verification of safety properties recognizable by reversible automata and omega-properties recognizable by reversible Buechi automata.

  10. Halo White Dwarfs, Thick Disks and a Sanity Check

    OpenAIRE

    Hansen, Brad M. S.

    2001-01-01

    The discovery of a population of high proper motion white dwarfs by Oppenheimer et al (2001) has caused a lot of speculation as to the origin of these stars. I show that the age distribution of the white dwarfs offers a kind of sanity check in these discussions. In particular, this population appears to have a similar age distribution to those in the standard, thin disk white dwarf population. This is not what is expected for either the halo or thick disk, which are thought to be old populati...

  11. Stochastic Model Checking of the Stochastic Quality Calculus

    DEFF Research Database (Denmark)

    Nielson, Flemming; Nielson, Hanne Riis; Zeng, Kebin

    2015-01-01

    The Quality Calculus uses quality binders for input to express strategies for continuing the computation even when the desired input has not been received. The Stochastic Quality Calculus adds generally distributed delays for output actions and real-time constraints on the quality binders for inp...... based on stochastic model checking and we compute closed form solutions for a number of interesting scenarios. The analyses are applied to the design of an intelligent smart electrical meter of the kind to be installed in European households by 2020....

  12. An efficient decoding for low density parity check codes

    Science.gov (United States)

    Zhao, Ling; Zhang, Xiaolin; Zhu, Manjie

    2009-12-01

    Low density parity check (LDPC) codes are a class of forward-error-correction codes. They are among the best-known codes capable of achieving low bit error rates (BER) approaching Shannon's capacity limit. Recently, LDPC codes have been adopted by the European Digital Video Broadcasting (DVB-S2) standard, and have also been proposed for the emerging IEEE 802.16 fixed and mobile broadband wireless-access standard. The consultative committee for space data system (CCSDS) has also recommended using LDPC codes in the deep space communications and near-earth communications. It is obvious that LDPC codes will be widely used in wired and wireless communication, magnetic recording, optical networking, DVB, and other fields in the near future. Efficient hardware implementation of LDPC codes is of great interest since LDPC codes are being considered for a wide range of applications. This paper presents an efficient partially parallel decoder architecture suited for quasi-cyclic (QC) LDPC codes using Belief propagation algorithm for decoding. Algorithmic transformation and architectural level optimization are incorporated to reduce the critical path. First, analyze the check matrix of LDPC code, to find out the relationship between the row weight and the column weight. And then, the sharing level of the check node updating units (CNU) and the variable node updating units (VNU) are determined according to the relationship. After that, rearrange the CNU and the VNU, and divide them into several smaller parts, with the help of some assistant logic circuit, these smaller parts can be grouped into CNU during the check node update processing and grouped into VNU during the variable node update processing. These smaller parts are called node update kernel units (NKU) and the assistant logic circuit are called node update auxiliary unit (NAU). With NAUs' help, the two steps of iteration operation are completed by NKUs, which brings in great hardware resource reduction. Meanwhile

  13. Performance checking of an indigenously fabricated TIMS: evaluation of accuracy

    International Nuclear Information System (INIS)

    Performance checking of the indigenously fabricated multi-collector Thermal ionization mass spectrometer (TIMS) was continued prior to commissioning it for the determination of isotopic composition of plutonium. In an earlier paper, results of the precision obtained for Nd isotopes (142-146) were reported. Thereafter, a number of changes were made for improving the precision. In the present paper, results obtained for 235U/238U ratios for SRM standard are reported along with the results for precision and accuracy obtained by the TIMS

  14. Energy Audit Checks - A socioeconomic assessment; Energikartlaeggningscheckar - En samhaellsekonomisk utvaerdering

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-09-01

    This review is part of the Swedish Energy Agency's work with skills and methodology development on economic analyzes. The present socioeconomic analysis is the first of its kind to evaluate the current support for energy audit checks and is based on the instrument's purpose, goals and obstacles. Cost effectiveness is the main focus, as well as a description of the instrument's benefits and costs. The evaluation also aims to further develop the instrument in conjunction with the implementation of energy efficiency directive. Proposals for new instruments have however not been part of the mission.

  15. Android Security (Decompilation of APK File to Check Permissions

    Directory of Open Access Journals (Sweden)

    Hemant Bansal

    2016-01-01

    Full Text Available The world wide revolution in Android technology is changing our lives in term of the way we learn and use. Android Security fits into this because the technology has been around long enough and can provide various benefits for security in this area. The main objective of this paper is to Decompile the Android App And Check the permissions Used By That App (What The permissions any app is accessing Like reading messages, Using our internet data, reading our call logs. This Research Paper Helps Peoples To aware About the Un necessary Applications and Their Permissions That Are in Our Phone Stealing Our Credit Card details, secret details etc.

  16. Symbolic Game Semantics for Model Checking Program Families

    DEFF Research Database (Denmark)

    Dimovski, Aleksandar

    this paper, we propose an efficient game semantics based approach for verifying open program families, i.e. program families with free (undefined) identifiers. We use symbolic representation of algorithmic game semantics, where concrete values are replaced with symbolic ones. In this way, we can...... compactly represent program families with infinite integers as so-called (finite-state) featured symbolic automata. Specifically designed model checking algorithms are then employed to verify safety of all programs from a family at once and pinpoint those programs that are unsafe (respectively, safe). We...

  17. Towards an Authorization Framework for App Security Checking

    OpenAIRE

    Hallett, Joseph; Aspinall, David

    2014-01-01

    Apps don't come with any guarantees that they are not malicious. This paper introduces a PhD project designing the authorization framework used for App Guarden. App Guarden is a new project that uses a exible assurance framework based on distribution of evidence, attestation and checking algorithms to make explicit why an app isn't dangerous and to allow users to describe how they want apps on their devices to behave. We use the SecPAL policy language to implement a device policy and give a b...

  18. Daily check of the electron beams with a diode system

    Energy Technology Data Exchange (ETDEWEB)

    Pilette, P. [Hospital Civil de Charleroi (Belgium). Centre for Radiotherapy

    1995-12-01

    A fast systems to check all the accelerator beams on a daily basis has been developed. A cheap home-made detector, based on non-medical diodes (type 1N5408), has been used since July 1992 to verify all the electron beams every day. The relative energy and Top-cGy correspondence is verified with one single irradiation of less than 1 minute by 6 diodes fixed in a polystyrene phantom. The principle of construction, software implementation and results are presented.

  19. Model Checking Data Consistency for Cache Coherence Protocols

    Institute of Scientific and Technical Information of China (English)

    Hong Pan; Hui-Min Lin; Yi Lv

    2006-01-01

    A method for automatic verification of cache coherence protocols is presented, in which cache coherence protocols are modeled as concurrent value-passing processes, and control and data consistency requirement are described as formulas in first-orderμ-calculus. A model checker is employed to check if the protocol under investigation satisfies the required properties. Using this method a data consistency error has been revealed in a well-known cache coherence protocol.The error has been corrected, and the revised protocol has been shown free from data consistency error for any data domain size, by appealing to data independence technique.

  20. Thermodynamic check calculation for the turboset of CEFR

    International Nuclear Information System (INIS)

    CEFR is the first sodium coolant fast reactor in China. The main function of the three loops is to transform the heat energy from the nuclear island to electricity energy. The turboset has completed three auxiliary steam impact tests and the grid-connected power generation test in 40% P0 working condition after installed and commissioned, but its rated power thermodynamic performance cannot be demonstrated at all times. By thermodynamic check calculation, this paper demonstrates that its capacity at rated power and gets its thermal economics. It also provides significant reference for the whole plant thermal equilibrium calculation of CEFR. (authors)

  1. Regenerable Microbial Check Valve - Life cycle tests results

    Science.gov (United States)

    Atwater, James E.; Wheeler, Richard R., Jr.; Olivadoti, J. T.; Sauer, Richard L.; Flanagan, David T.

    1992-01-01

    Life cycle regeneration testing of the Microbial Check Valve (MCV) that is used on the Shuttle Orbiter to provide microbial control of potable water is currently in progress. Four beds are being challenged with simulated reclaimed waters and repeatedly regenerated. Preliminary results indicate that contaminant systems exhibit unique regeneration periodicities. Cyclic throughput diminishes with increasing cumulative flow. It is considered to be feasible to design a regenerable MCV system which will function without human intervention and with minimal resupply penalty for the 30 year life of the Space Station.

  2. Antiphospholipid antibodies and infertility.

    Science.gov (United States)

    Chighizola, C B; de Jesus, G R

    2014-10-01

    Since the late 1980s some publications have proposed that antiphospholipid antibodies (aPL) may have some relationship with infertility, considering reported deleterious effects that aPL exert on trophoblast proliferation and growth. Although not included in current classification criteria for antiphospholipid syndrome, many physicians investigate for aPL in patients with a history of infertility, including antibodies not listed in classification criteria, and most of those patients will receive anticoagulant therapy if any of those antibodies have a result considered positive. A review of literature was conducted searching for studies that investigated the association of aPL and infertility and if aPL positivity alters in vitro fertilization (IVF) outcome. The definition of infertility, routine work-up to exclude other causes of infertility, definition of IVF failure as inclusion criteria and control populations were heterogeneous among studies. Most of them enrolled women over 40 years of age, and exclusion of other confounding factors was also inconsistent. Of 29 studies that assessed aPL positivity rates in infertile women, the majority had small sample sizes, implying a lack of power, and 13 (44.8%) reported higher frequency of aPL in infertile patients compared to controls, but most of them investigated a panel of non-criteria aPL tests, whose clinical significance is highly controversial. Only two studies investigated all three criteria tests, and medium-high titer of anticardiolipin cut-off conforming to international guidelines was used in one study. Considering IVF outcome, there was also disparity in this definition: few studies assessed the live birth rate, others the implantation rate. Of 14 publications that addressed the relationship between aPL and IVF outcome, only two described a detrimental effect of these autoantibodies. In conclusion, available data do not support an association between aPL and infertility, and aPL positivity does not seem to

  3. 76 FR 69287 - National Instant Criminal Background Check System Section Agency Information Collection...

    Science.gov (United States)

    2011-11-08

    ... Criminal Justice Information Services (CJIS) Division's National Instant Criminal Background Check System... Federal Bureau of Investigation National Instant Criminal Background Check System Section Agency... Sherry L. Kuneff, Management and Program Analyst, FBI, Criminal Justice Information Services...

  4. Tester automatically checks insulation of individual conductors in multiple-strand cables

    Science.gov (United States)

    Shaw, J.; Vuckovich, M.

    1967-01-01

    Insulation tester checks multiple-strand electrical cables in nuclear rocket reactors. It has both manual and automatic capabilities and can check the insulation of a cable with 200 or more conductors in a few minutes.

  5. The research of the stud bolt bore checking equipment of the nuclear reactor pressure vessel

    International Nuclear Information System (INIS)

    This article introduces a kind of new equipment that can work under the environment of high radiation and can-automaticly check the main stud bolt bore. The technical parameters and key techniques of the checking equipment are presented. (authors)

  6. Targeting of Antibodies using Aptamers

    OpenAIRE

    Missailidis, Sotiris

    2003-01-01

    The chapter presents a methodology for the rapid selection of aptamers against antibody targets. It is a detailed account of the various methodological steps that describe the selection of aptamers, including PCR steps, buffers to be used, target immobilisation, partitioning and amplification of aptamers, clonning and sequencing, to results in high affinity and specificity ligands for the chosen target antibody.

  7. Refolding Technologies for Antibody Fragments

    OpenAIRE

    Tsutomu Arakawa; Daisuke Ejima

    2014-01-01

    Refolding is one of the production technologies for pharmaceutical grade antibody fragments. Detergents and denaturants are primarily used to solubilize the insoluble proteins. The solubilized and denatured proteins are refolded by reducing the concentration of the denaturants or detergents. Several refolding technologies have been used for antibody fragments, comprising dilution, dialysis, solid phase solvent exchange and size exclusion chromatography, as reviewed here. Aggregation suppresso...

  8. ANTISPERM ANTIBODIES IN VASOVASOSTOMY

    Directory of Open Access Journals (Sweden)

    Gholamreza Pourmand

    1993-06-01

    Full Text Available Two hundred and forty patients, who had undergone vasectomy from 1977 to 1985 and subsequent vasovasostomy ,were studied for the presence of sperm-specific antibodies by using the Kibrick's gelatin agglutination test. The number of successful pregnancies and the presence of agglutination were also considered in this survey. Sixty-nine pregnancies occurred in total and agglutination was present in 49% out of 51% positive specimens by the Kibrick Test."nThe average sperm motility was slightly higher in the negative Kibrick group than in the positive Kibrick group. The obtained data indicated that there seems to be a relationship between the increased titers and percentage of agglutination in semen samples.

  9. Metrics for antibody therapeutics development.

    Science.gov (United States)

    Reichert, Janice M

    2010-01-01

    A wide variety of full-size monoclonal antibodies (mAbs) and therapeutics derived from alternative antibody formats can be produced through genetic and biological engineering techniques. These molecules are now filling the preclinical and clinical pipelines of every major pharmaceutical company and many biotechnology firms. Metrics for the development of antibody therapeutics, including averages for the number of candidates entering clinical study and development phase lengths for mAbs approved in the United States, were derived from analysis of a dataset of over 600 therapeutic mAbs that entered clinical study sponsored, at least in part, by commercial firms. The results presented provide an overview of the field and context for the evaluation of on-going and prospective mAb development programs. The expansion of therapeutic antibody use through supplemental marketing approvals and the increase in the study of therapeutics derived from alternative antibody formats are discussed. PMID:20930555

  10. Model Checking Degrees of Belief in a System of Agents

    Science.gov (United States)

    Raimondi, Franco; Primero, Giuseppe; Rungta, Neha

    2014-01-01

    Reasoning about degrees of belief has been investigated in the past by a number of authors and has a number of practical applications in real life. In this paper we present a unified framework to model and verify degrees of belief in a system of agents. In particular, we describe an extension of the temporal-epistemic logic CTLK and we introduce a semantics based on interpreted systems for this extension. In this way, degrees of beliefs do not need to be provided externally, but can be derived automatically from the possible executions of the system, thereby providing a computationally grounded formalism. We leverage the semantics to (a) construct a model checking algorithm, (b) investigate its complexity, (c) provide a Java implementation of the model checking algorithm, and (d) evaluate our approach using the standard benchmark of the dining cryptographers. Finally, we provide a detailed case study: using our framework and our implementation, we assess and verify the situational awareness of the pilot of Air France 447 flying in off-nominal conditions.

  11. Model checking as an aid to procedure design

    International Nuclear Information System (INIS)

    The OECD Halden Reactor Project has been actively working on computer assisted operating procedures for many years. The objective of the research has been to provide computerised assistance for procedure design, verification and validation, implementation and maintenance. For the verification purpose, the application of formal methods has been considered in several reports. The recent formal verification activity conducted at the Halden Project is based on using model checking to the verification of procedures. This report presents verification approaches based on different model checking techniques and tools for the formalization and verification of operating procedures. Possible problems and relative merits of the different approaches are discussed. A case study of one of the approaches is presented to show the practical application of formal verification. Application of formal verification in the traditional procedure design process can reduce the human resources involved in reviews and simulations, and hence reduce the cost of verification and validation. A discussion of the integration of the formal verification with the traditional procedure design process is given at the end of this report. (Author)

  12. SoS contract verification using statistical model checking

    Directory of Open Access Journals (Sweden)

    Alessandro Mignogna

    2013-11-01

    Full Text Available Exhaustive formal verification for systems of systems (SoS is impractical and cannot be applied on a large scale. In this paper we propose to use statistical model checking for efficient verification of SoS. We address three relevant aspects for systems of systems: 1 the model of the SoS, which includes stochastic aspects; 2 the formalization of the SoS requirements in the form of contracts; 3 the tool-chain to support statistical model checking for SoS. We adapt the SMC technique for application to heterogeneous SoS. We extend the UPDM/SysML specification language to express the SoS requirements that the implemented strategies over the SoS must satisfy. The requirements are specified with a new contract language specifically designed for SoS, targeting a high-level English- pattern language, but relying on an accurate semantics given by the standard temporal logics. The contracts are verified against the UPDM/SysML specification using the Statistical Model Checker (SMC PLASMA combined with the simulation engine DESYRE, which integrates heterogeneous behavioral models through the functional mock-up interface (FMI standard. The tool-chain allows computing an estimation of the satisfiability of the contracts by the SoS. The results help the system architect to trade-off different solutions to guide the evolution of the SoS.

  13. Model-checking techniques based on cumulative residuals.

    Science.gov (United States)

    Lin, D Y; Wei, L J; Ying, Z

    2002-03-01

    Residuals have long been used for graphical and numerical examinations of the adequacy of regression models. Conventional residual analysis based on the plots of raw residuals or their smoothed curves is highly subjective, whereas most numerical goodness-of-fit tests provide little information about the nature of model misspecification. In this paper, we develop objective and informative model-checking techniques by taking the cumulative sums of residuals over certain coordinates (e.g., covariates or fitted values) or by considering some related aggregates of residuals, such as moving sums and moving averages. For a variety of statistical models and data structures, including generalized linear models with independent or dependent observations, the distributions of these stochastic processes tinder the assumed model can be approximated by the distributions of certain zero-mean Gaussian processes whose realizations can be easily generated by computer simulation. Each observed process can then be compared, both graphically and numerically, with a number of realizations from the Gaussian process. Such comparisons enable one to assess objectively whether a trend seen in a residual plot reflects model misspecification or natural variation. The proposed techniques are particularly useful in checking the functional form of a covariate and the link function. Illustrations with several medical studies are provided. PMID:11890304

  14. Generalized Symbolic Execution for Model Checking and Testing

    Science.gov (United States)

    Khurshid, Sarfraz; Pasareanu, Corina; Visser, Willem; Kofmeyer, David (Technical Monitor)

    2003-01-01

    Modern software systems, which often are concurrent and manipulate complex data structures must be extremely reliable. We present a novel framework based on symbolic execution, for automated checking of such systems. We provide a two-fold generalization of traditional symbolic execution based approaches: one, we define a program instrumentation, which enables standard model checkers to perform symbolic execution; two, we give a novel symbolic execution algorithm that handles dynamically allocated structures (e.g., lists and trees), method preconditions (e.g., acyclicity of lists), data (e.g., integers and strings) and concurrency. The program instrumentation enables a model checker to automatically explore program heap configurations (using a systematic treatment of aliasing) and manipulate logical formulae on program data values (using a decision procedure). We illustrate two applications of our framework: checking correctness of multi-threaded programs that take inputs from unbounded domains with complex structure and generation of non-isomorphic test inputs that satisfy a testing criterion. Our implementation for Java uses the Java PathFinder model checker.

  15. Assertion checking environment (ACE) for formal verification of C programs

    International Nuclear Information System (INIS)

    In this paper we describe an Assertion Checking Environment (ACE) for compositional verification of programs, which are written in an industrially sponsored safe subset of C programming language called MISRA C [Guidelines for the Use of the C Language in Vehicle Based Software, 1998]. The theory is based on Hoare logic [Commun. ACM 12 (1969) 576] and the C programs are verified using static assertion checking technique. First the functional specifications of the program, captured in the form of pre- and post-conditions for each C function, are derived from the specifications. These pre- and post-conditions are then introduced as assertions (also called annotations or formal comments) in the program code. The assertions are then proved formally using ACE and theorem proving tool called Stanford Temporal Prover [The Stanford Temporal Prover User's Manual, 1998]. ACE has been developed by us and consists mainly of a translator c2spl, a GUI and some utility programs. The technique and tools developed are targeted towards verification of real-time embedded software

  16. Reasoning About Strategies: On the Model-Checking Problem

    CERN Document Server

    Mogavero, Fabio; Perelli, Giuseppe; Vardi, Moshe Y

    2011-01-01

    In open systems verification, to formally check for reliability, one needs an appropriate formalism to model the interaction between agents and express the correctness of the system no matter how the environment behaves. An important contribution in this context is given by modal logics for strategic ability, in the setting of multi-agent games, such as ATL, ATL*, and the like. Recently, Chatterjee, Henzinger, and Piterman introduced Strategy Logic (CHP-SL), with the aim of getting a powerful framework for reasoning explicitly about strategies. CHP-SL is obtained by using first-order quantifications over strategies and it has been investigated in the setting of two-agents turned-based games, where a non-elementary model-checking algorithm has been provided. While CHP-SL is a very expressive logic, we claim that it does not fully capture the strategic aspects of multi-agent systems. In this paper, we introduce and study a more general strategy logic, denoted SL, for reasoning about strategies in multi-agent co...

  17. Epstein-Barr virus antibody test

    Science.gov (United States)

    EBV antibody test; EBV serology ... a lab, where a lab specialist looks for antibodies to the Epstein-Barr virus. In the first stages of an illness, little antibody may be detected. For this reason, the test ...

  18. Measurement of antibodies to tubulin by radioimmunoassay

    International Nuclear Information System (INIS)

    A solid-phase double antibody radioimmunoassay capable of measuring antibody to tubulin, the principal component of microtubules, is described. This assay is simple, combining sensitivity with specificity and also allowing determination of antibody subclasses. (Auth.)

  19. Antibodies - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    NCI announces the release of monoclonal antipeptide antibodies from rabbit for distribution on the antibody portal. There are 60 recently added monoclonal antibodies, with 56 generated from mouse and 4 generated from rabbit.

  20. 75 FR 24796 - FBI Records Management Division National Name Check Program Section User Fees

    Science.gov (United States)

    2010-05-06

    ... and related cost models based upon the concept and principles of activity-based costing (ABC). The...-based background checks conducted by the National Name Check Program (NNCP) of the Records Management... FBI's statutory authority to establish and collect fees for named-based NNCP checks and...

  1. The Effects of Check, Connect, and Expect on Behavioral and Academic Growth

    Science.gov (United States)

    McDaniel, Sara C.; Houchins, David E.; Robinson, Cecil

    2016-01-01

    "Check, Connect, and Expect" (CCE) is a secondary tier behavioral intervention that provides students with levels of support including a dedicated "coach" for check-in and check-out procedures, and social skills instruction. Elementary students (n = 22) in an alternative education school setting received CCE for 13 weeks…

  2. Combining Decision Diagrams and SAT Procedures for Efficient Symbolic Model Checking

    DEFF Research Database (Denmark)

    Williams, Poul Frederick; Biere, Armin; Clarke, Edmund M.;

    2000-01-01

    , combined with BDDs and SAT-solvers to perform satisfiability checking. As a result we are able to model check systems for which standard BDD-based methods fail. For example, we model check a liveness property of a 256 bit shift-and-add multiplier and we are able to find a previously undetected bug...

  3. 42 CFR 457.216 - Treatment of uncashed or canceled (voided) CHIP checks.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Treatment of uncashed or canceled (voided) CHIP... canceled (voided) CHIP checks. (a) Purpose. This section provides rules to ensure that States refund the... section— Canceled (voided) check means an CHIP check issued by a State or fiscal agent that prior to...

  4. Learn & Check - Integration von Wissenserwerb und Wissenskontrolle [10] [

    Directory of Open Access Journals (Sweden)

    Krammer, Sandra

    2006-02-01

    Full Text Available [english] The acquisition of knowledge with subsequent automatic check makes learning more effective. A learning environment is presented which follows these paradigms and integrates learning objects in the form of information units and exercise units. The learning objects are primarily sequentially arranged and summarised hierarchically into chapters; however, they can also be interlinked via metadata. A number of different types of quiz questions are available for the exercise units. The learner can work on the components of a course in a variety of modes. In the learning mode only the information units are seen, in the practice mode the practice units can be seen as well. In the drill mode, only those practice units can be worked upon which have previously been answered incorrectly. The complete learning contents are represented in XML in order to achieve a division between content, representation and sequential control. The implementation architecture allows for the efficient generation of web version and single-position version of the learning environment. On the basis of Learn & Check, a variety of learning systems were developed which are used in medical training curricular: for neurological liquor-diagnostics and for the subject "basics of medicine". [german] Wissenserwerb mit anschließender Selbstkontrolle macht Lernen effektiver. Es wird eine Lernumgebung vorgestellt, die diesem Paradigma folgt und Lernobjekte in Form von Informationseinheiten und Übungseinheiten integriert. Die Lernobjekte sind primär sequentiell angeordnet und hierarchisch zu Kapiteln zusammengefasst, sie können aber auch über Metadaten vernetzt werden. Für die Übungseinheiten stehen verschiedene Quizfragentypen zur Verfügung. Der Lerner kann die Teile eines Kurses in unterschiedlichen Modi bearbeiten. Im Lernmodus werden nur die Informationseinheiten gesehen, im Übungsmodus zusätzlich die Übungseinheiten. Im Paukmodus können nur die

  5. Check-hybrid GLDPC Codes: Systematic Elimination of Trapping Sets and Guaranteed Error Correction Capability

    OpenAIRE

    Ravanmehr, Vida; Khatami, Mehrdad; Declercq, David; Vasic, Bane

    2016-01-01

    In this paper, we propose a new approach to construct a class of check-hybrid generalized low-density parity-check (CH-GLDPC) codes which are free of small trapping sets. The approach is based on converting some selected check nodes involving a trapping set into super checks corresponding to a 2-error correcting component code. Specifically, we follow two main purposes to construct the check-hybrid codes; first, based on the knowledge of the trapping sets of the global LDPC code, single parit...

  6. Using Model Checking for Analyzing Distributed Power Control Problems

    Directory of Open Access Journals (Sweden)

    Thomas Brihaye

    2010-01-01

    Full Text Available Model checking (MC is a formal verification technique which has been known and still knows a resounding success in the computer science community. Realizing that the distributed power control (PC problem can be modeled by a timed game between a given transmitter and its environment, the authors wanted to know whether this approach can be applied to distributed PC. It turns out that it can be applied successfully and allows one to analyze realistic scenarios including the case of discrete transmit powers and games with incomplete information. The proposed methodology is as follows. We state some objectives a transmitter-receiver pair would like to reach. The network is modeled by a game where transmitters are considered as timed automata interacting with each other. The objectives are then translated into timed alternating-time temporal logic formulae and MC is exploited to know whether the desired properties are verified and determine a winning strategy.

  7. Check of OH rotational temperature using an interferometric method

    International Nuclear Information System (INIS)

    This paper presents an interferometric method used to check the rotational temperature of the OH free radical obtained using emission spectroscopy. The temperature is extracted from an interferogram via the phase shifting introduced by the refractive index of the studied medium. The refractive index is related to the temperature through the Gladstone-Dale equation and the ideal gas law. The method is tested on the laminar premixed flame of an oxy-acetylene burner and on the laminar plume of a dc argon plasma torch. The results obtained are compared with those obtained from the UV OH band at 306.357 nm (transition A2Σ, ν = 0 → X2Π, ν' = 0) by emission spectroscopy using the Boltzmann plot method and using a method based on numerical simulated spectra with the amplitude ratios of groups of unresolved rotational lines

  8. Routine health check-ups of unemployed in Norway.

    Science.gov (United States)

    Ytterdahl, T

    1999-01-01

    In 1994 all the 273 long-term unemployed in the municipality Lillesand, Norway were invited to participate in a proactive health care program. 229 were included in the program, consisting of a medical examination by a general practitioner, councelling, personal support and referrals. The job-loss aroused lots of negative emotions, mostly defensive feelings and resignations, which are likely to reduce self-esteem and coping ability. The prevalence of somatoform symptoms and anxiety was twice as high as in the normal population, and for depression the prevalence was three times higher. 24% of the unemployed were referred to further examination. Invitation to a health examination may be the ticket of entry for revealing some of the concealed morbidity among long-term unemployed. Health check-ups of unemployed will probably be very cost-effective PMID:10197474

  9. A Formal Verification Methodology for Checking Data Integrity

    CERN Document Server

    Umezawa, Yasushi

    2011-01-01

    Formal verification techniques have been playing an important role in pre-silicon validation processes. One of the most important points considered in performing formal verification is to define good verification scopes; we should define clearly what to be verified formally upon designs under tests. We considered the following three practical requirements when we defined the scope of formal verification. They are (a) hard to verify (b) small to handle, and (c) easy to understand. Our novel approach is to break down generic properties for system into stereotype properties in block level and to define requirements for Verifiable RTL. Consequently, each designer instead of verification experts can describe properties of the design easily, and formal model checking can be applied systematically and thoroughly to all the leaf modules. During the development of a component chip for server platforms, we focused on RAS (Reliability, Availability, and Serviceability) features and described more than 2000 properties in...

  10. Shuttle Atlantis is used for Safe Haven fit check

    Science.gov (United States)

    2000-01-01

    Shuttle Atlantis, with twin solid rocket boosters and external tank atop the Mobile Launcher Platform and Crawler-Transporter, inches toward high bay 2, on the west side, in the Vehicle Assembly Building (VAB). For the first time in Space Shuttle history, a fully stacked Shuttle is moving into the bay. The VAB and nearby rock-paved crawlerway have recently undergone major modifications to provide Shuttle flight hardware more storage space and protection '''Safe Haven''' - from hurricanes or tropical storms. Atlantis began moving out of VAB high bay 1 on the east side at 2:59 a.m. EDT. After the successful Safe Haven fit check, Shuttle Atlantis is scheduled to roll out to Launch Pad 39B in preparation for the STS-106 launch on Sept. 8.

  11. A Succinct Approach to Static Analysis and Model Checking

    DEFF Research Database (Denmark)

    Filipiuk, Piotr

    In a number of areas software correctness is crucial, therefore it is often desirable to formally verify the presence of various properties or the absence of errors. This thesis presents a framework for concisely expressing static analysis and model checking problems. The framework facilitates...... guarantees that there always is single best solution for a problem under consideration. We also develop a solving algorithm, based on a dierential worklist, that computes the least solution guaranteed by the Moore Family result. Furthermore, we present a logic for specifying analysis problems called Layered...... Fixed Point Logic. Its most prominent feature is the direct support for both inductive computations of behaviors as well as co-inductive specications of properties. Two main theoretical contributions are a Moore Family result and a parametrized worst-case time complexity result. We develop a BDD...

  12. Analysis of the Security of BB84 by Model Checking

    CERN Document Server

    Elboukhari, Mohamed; Azizi, Abdelmalek; 10.5121/ijnsa.2010.2207

    2010-01-01

    Quantum Cryptography or Quantum key distribution (QKD) is a technique that allows the secure distribution of a bit string, used as key in cryptographic protocols. When it was noted that quantum computers could break public key cryptosystems based on number theory extensive studies have been undertaken on QKD. Based on quantum mechanics, QKD offers unconditionally secure communication. Now, the progress of research in this field allows the anticipation of QKD to be available outside of laboratories within the next few years. Efforts are made to improve the performance and reliability of the implemented technologies. But several challenges remain despite this big progress. The task of how to test the apparatuses of QKD For example did not yet receive enough attention. These devises become complex and demand a big verification effort. In this paper we are interested in an approach based on the technique of probabilistic model checking for studying quantum information. Precisely, we use the PRISM tool to analyze ...

  13. Neurology check list. 5. rev. and enl. ed.; Checkliste Neurologie

    Energy Technology Data Exchange (ETDEWEB)

    Grehl, Holger [Evangelisches und Johanniter Klinikum, Duisburg (Germany). Neurologische Klinik; Reinhardt, Frank

    2013-02-01

    The neurology check list covers the following issues, organized in four parts: Grey part - diagnostic fundamentals, therapeutic principles: clinical neurological examination, liquor puncture, specific laboratory diagnostics, neurophysical diagnostics, imaging techniques, therapeutic principles, legal aspects, neurological assessment. Green Part - leading syndromes and leading symptoms. Blue part - neurological disease appearance: pains in head and face, pain syndrome, congenital and development disturbances, liquor circulation disturbances, ZNS hemorrhages, tumors and neoplasm, paraneoplastic syndromes, inflammatory diseases of the nervous system, dementia diseases, metabolic and other encephalopathy, cerebellum diseases and system surmounting processes, movement degeneration, basal ganglion diseases, epilepsy, non-epileptic attacks, medulla diseases, brain nerve diseases, plexus lesions, radicular lesions, peripheric neuropathy, neuromuscular transfer disturbances, muscular diseases. Red part: neurological intensive medicine.

  14. LHCb: Analysing DIRAC's Behavior using Model Checking with Process Algebra

    CERN Multimedia

    Remenska, Daniela

    2012-01-01

    DIRAC is the Grid solution designed to support LHCb production activities as well as user data analysis. Based on a service-oriented architecture, DIRAC consists of many cooperating distributed services and agents delivering the workload to the Grid resources. Services accept requests from agents and running jobs, while agents run as light-weight components, fulfilling specific goals. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check for changes in the service states, and react to these accordingly. A characteristic of DIRAC's architecture is the relatively low complexity in the logic of each agent; the main source of complexity lies in their cooperation. These agents run concurrently, and communicate using the services' databases as a shared memory for synchronizing the state transitions. Although much effort is invested in making DIRAC reliable, entities occasionally get into inconsistent states, leadi...

  15. Checking the Quality of Clinical Guidelines using Automated Reasoning Tools

    CERN Document Server

    Hommersom, Arjen; van Bommel, Patrick

    2008-01-01

    Requirements about the quality of clinical guidelines can be represented by schemata borrowed from the theory of abductive diagnosis, using temporal logic to model the time-oriented aspects expressed in a guideline. Previously, we have shown that these requirements can be verified using interactive theorem proving techniques. In this paper, we investigate how this approach can be mapped to the facilities of a resolution-based theorem prover, Otter, and a complementary program that searches for finite models of first-order statements, Mace. It is shown that the reasoning required for checking the quality of a guideline can be mapped to such fully automated theorem-proving facilities. The medical quality of an actual guideline concerning diabetes mellitus 2 is investigated in this way.

  16. Use of statistical checks as maintenance tools for TLD readers

    International Nuclear Information System (INIS)

    Although the values of different parameters may remain within permissible limits during the operation of a thermoluminescent dosemeter (TLD) reader, certain effects can become apparent only when a long-term followup of these parameters is performed. In order to ensure an accurate and reliable operation of a TLD reader, the system characteristics must be monitored continuously. Long-term statistical checks of key system parameters may give a broader insight into the operational characteristics of the TLD reader and may help for proper maintenance of the system. The photomultipliers noise, the internal reference light source stability and the A to D reference voltage were found to be critical parameters, which have a major influence on the accuracy and stability of the system. A followup of these parameters for a period of about 10 y is presented, and some problems are seen to be reflected in the distributions. (authors)

  17. DEPUTY:Analysing Architectural Structures and Checking Style

    Institute of Scientific and Technical Information of China (English)

    D.Gorshkov; J.P.Wellisch

    2001-01-01

    The DepUty(dependencies utility)can be classified as a project and process management tool.The main goal of DepUty is to assist by means of source code analysis and graphical representation using UML,in understanding dependencies of sub-systems and packages in CMS object Oriented software,to understand architectureal structure,and to schedule code release in modularised integration.It also allows a new-comer to more easily understand the global structure, of CMS software,and to void circular dependencies up-front or re-factor the code,in case it was already too close to the edge of non-maintainability.We will discuss the various views DepUty provides to analyse package dependencies and illustrate both the metrics and style checking facilities it provides.

  18. Model-checking dense-time Duration Calculus

    DEFF Research Database (Denmark)

    Fränzle, Martin

    2004-01-01

    Since the seminal work of Zhou Chaochen, M. R. Hansen, and P. Sestoft on decidability of dense-time Duration Calculus [Zhou, Hansen, Sestoft, 1993] it is well-known that decidable fragments of Duration Calculus can only be obtained through withdrawal of much of the interesting vocabulary of this...... logic. While this was formerly taken as an indication that key-press verification of implementations with respect to elaborate Duration Calculus specifications were also impossible, we show that the model property is well decidable for realistic designs which feature natural constraints on their...... suitably sparser model classes we obtain model-checking procedures for rich subsets of Duration Calculus. Together with undecidability results also obtained, this sheds light upon the exact borderline between decidability and undecidability of Duration Calculi and related logics....

  19. Constraint-based deadlock checking of high-level specifications

    DEFF Research Database (Denmark)

    Hallerstede, Stefan; Leuschel, Michael

    2011-01-01

    Establishing the absence of deadlocks is important in many applications of formal methods. The use of model checking for finding deadlocks in formal models is limited because in many industrial applications the state space is either infinite or much too large to be explored exhaustively....... In this paper we propose a constraint-based approach to finding deadlocks employing the ProB constraint solver to find values for the constants and variables of formal models that describe a deadlocking state. We present the general technique, as well as various improvements that had to be performed on Pro......B's Prolog kernel, such as reification of membership and arithmetic constraints. ProB typically finds counter examples to deadlock-freedom constraints, a formula of about 900 partly nested conjunctions and disjunction among them 80 arithmetic and 150 set-theoretic predicates (in total a formula of 30 pages...

  20. Application of function generator for checking reactivity meter accuracy

    International Nuclear Information System (INIS)

    The accuracy of reactivity meters is usually checked with a reactor kinetic simulator operating to an accuracy exceeding the expected accuracy of the measuring device. The present report describes a method to evaluate accuracy by comparing the response R(t) of the reactivity meter to a given function n(t) with the value of the reactivity function r(t) calculated from the same input function instead of using the input reference signal r(t) to the simulator with the output signal R(t) from the reactivity meter. This method has been successfully used by applying sawtooth and exponential input signals for the determination of the accuracy of reactivity meters developed in the Central Research Institute for Physics. (author)

  1. Technophobia, prescription checking and the future of diabetes management.

    Science.gov (United States)

    Albisser, A M

    2009-06-01

    Is the medical prescription the root cause of the long-term complications of diabetes mellitus? This article presents the argument for introducing prescription checking into diabetes disease management. It discusses an evidence-based need for frequent revisions of the medical prescription as the key to preventing treatment-related complications in diabetes while achieving the now mandated standards in patient care. To do this it will be prudent for diabetes healthcare providers to enrich their clinical services with new information technology-based tools. These are easily acquired by participating in professional workshops focused on advanced diabetes management. In this light, the case presented here challenges leading practitioners to become early participants in the evolution of information technology that will ultimately enhance the management of all patients with diabetes. PMID:19357829

  2. SimCheck: An Expressive Type System for Simulink

    Science.gov (United States)

    Roy, Pritam; Shankar, Natarajan

    2010-01-01

    MATLAB Simulink is a member of a class of visual languages that are used for modeling and simulating physical and cyber-physical systems. A Simulink model consists of blocks with input and output ports connected using links that carry signals. We extend the type system of Simulink with annotations and dimensions/units associated with ports and links. These types can capture invariants on signals as well as relations between signals. We define a type-checker that checks the wellformedness of Simulink blocks with respect to these type annotations. The type checker generates proof obligations that are solved by SRI's Yices solver for satisfiability modulo theories (SMT). This translation can be used to detect type errors, demonstrate counterexamples, generate test cases, or prove the absence of type errors. Our work is an initial step toward the symbolic analysis of MATLAB Simulink models.

  3. Cross-checking different sources of mobility information

    CERN Document Server

    Lenormand, Maxime; Cantu-Ros, Oliva G; Tugores, Antonia; Louail, Thomas; Herranz, Ricardo; Barthelemy, Marc; Frias-Martinez, Enrique; Ramasco, Jose J

    2014-01-01

    The pervasive use of new mobile devices has allowed a better characterization in space and time of human concentrations and mobility in general. Besides its theoretical interest, describing mobility is of great importance for a number of practical applications ranging from the forecast of disease spreading to the design of new spaces in urban environments. While classical data sources, such as surveys or census, have a limited level of geographical resolution (e.g., districts, municipalities, counties are typically used) or are restricted to generic workdays or weekends, the data coming from mobile devices can be precisely located both in time and space. Most previous works have used a single data source to study human mobility patterns. Here we perform instead a cross-check analysis by comparing results obtained with data collected from three different sources: Twitter, census and cell phones. The analysis is focused on the urban areas of Barcelona and Madrid, for which data of the three types is available. ...

  4. Constraint-Based Deadlock Checking of High-Level Specifications

    CERN Document Server

    Hallerstede, Stefan

    2011-01-01

    Establishing the absence of deadlocks is important in many applications of formal methods. The use of model checking for finding deadlocks in formal models is often limited. In this paper we propose a constraint-based approach to finding deadlocks employing the ProB constraint solver. We present the general technique, as well as various improvements that had to be performed on ProB's Prolog kernel, such as reification of membership and arithmetic constraints. This work was guided by an industrial case study, where a team from Bosch was modeling a cruise control system. Within this case study, ProB was able to quickly find counter examples to very large deadlock-freedom constraints. In the paper, we also present other successful applications of this new technique. Experiments using SAT and SMT solvers on these constraints were thus far unsuccessful.

  5. Applying Model Checking to Industrial-Sized PLC Programs

    CERN Document Server

    AUTHOR|(CDS)2079190; Darvas, Daniel; Blanco Vinuela, Enrique; Tournier, Jean-Charles; Bliudze, Simon; Blech, Jan Olaf; Gonzalez Suarez, Victor M

    2015-01-01

    Programmable logic controllers (PLCs) are embedded computers widely used in industrial control systems. Ensuring that a PLC software complies with its specification is a challenging task. Formal verification has become a recommended practice to ensure the correctness of safety-critical software but is still underused in industry due to the complexity of building and managing formal models of real applications. In this paper, we propose a general methodology to perform automated model checking of complex properties expressed in temporal logics (\\eg CTL, LTL) on PLC programs. This methodology is based on an intermediate model (IM), meant to transform PLC programs written in various standard languages (ST, SFC, etc.) to different modeling languages of verification tools. We present the syntax and semantics of the IM and the transformation rules of the ST and SFC languages to the nuXmv model checker passing through the intermediate model. Finally, two real cases studies of \\CERN PLC programs, written mainly in th...

  6. Methods to model-check parallel systems software.

    Energy Technology Data Exchange (ETDEWEB)

    Matlin, O. S.; McCune, W.; Lusk, E.

    2003-12-15

    We report on an effort to develop methodologies for formal verification of parts of the Multi-Purpose Daemon (MPD) parallel process management system. MPD is a distributed collection of communicating processes. While the individual components of the collection execute simple algorithms, their interaction leads to unexpected errors that are difficult to uncover by conventional means. Two verification approaches are discussed here: the standard model checking approach using the software model checker SPIN and the nonstandard use of a general-purpose first-order resolution-style theorem prover OTTER to conduct the traditional state space exploration. We compare modeling methodology and analyze performance and scalability of the two methods with respect to verification of MPD.

  7. Checking the new IRI model The bottomside B parameters

    CERN Document Server

    Mosert, M; Ezquer, R; Lazo, B; Miro, G

    2002-01-01

    Electron density profiles obtained at Pruhonice (50.0, 15.0), El Arenosillo (37.1, 353.2) and Havana (23, 278) were used to check the bottom-side B parameters BO (thickness parameter) and B1 (shape parameter) predicted by the new IRI - 2000 version. The electron density profiles were derived from ionograms using the ARP technique. The data base includes daytime and nighttime ionograms recorded under different seasonal and solar activity conditions. Comparisons with IRI predictions were also done. The analysis shows that: a) The parameter B1 given by IRI 2000 reproduces better the observed ARP values than the IRI-90 version and b) The observed BO values are in general well reproduced by both IRI versions: IRI-90 and IRI-2000.

  8. Using Hybrid Decision Tree -Houph Transform Approach For Automatic Bank Check Processing

    Directory of Open Access Journals (Sweden)

    Heba A. Elnemr

    2012-05-01

    Full Text Available One of the first steps in the realization of an automatic system of bank check processing is the automatic classification of checks and extraction of handwritten area. This paper presents a new hybrid method which couple together the statistical color histogram features, the entropy, the energy and the Houph transform to achieve the automatic classification of checks as well as the segmentation and recognition of the various information on the check. The proposed method relies on two stages. First, a two-step classification algorithm is implemented. In the first step, a decision classification tree is built using the entropy, the energy, the logo location and histogram features of colored bank checks. These features are used to classify checks into several groups. Each group may contain one or more type of checks. Therefore, in the second step the bank logo or bank name are matched against its stored template to identify the correct prototype. Second, Hough transform is utilized to detect lines in the classified checks. These lines are used as indicator to the bank check fields. A group of experiments is performed showing that the proposed technique is promising as regards classifying the bank checks and extracting the important fields in that check.

  9. Loess Plateau check dams can potentially sequester eroded soil organic carbon

    Science.gov (United States)

    Zhang, Haicheng; Liu, Shuguang; Yuan, Wenping; Dong, Wenjie; Xia, Jiangzhou; Cao, Yaojun; Jia, Yanwei

    2016-06-01

    Check dams are special soil and water conservation structures in the Loess Plateau, China. They play an important role in intercepting sediments and soil organic carbon (SOC). However, the decomposition of intercepted SOC and the environmental regulations at check dams have not been investigated. We conducted several paired field experiments at both check dams and slope lands in the Yanhe Watershed of the Loess Plateau to examine the characteristics of SOC decomposition at check dams. On average, the SOC mineralization rate in slope lands was approximately three times higher than in check dams. Increased soil moisture and compaction in check dams can constrain carbon mineralization by limiting the oxygen availability of SOC and can isolate substrate carbon from heterotrophic microorganisms. Our results indicate that check dams display a considerable potential for eroded SOC sequestration via reducing the soil respiration rate and highlight the important implications of lateral carbon redistribution and human engineering projects when estimating regional or global ecosystem carbon cycles.

  10. Comparative evaluation of Map-Check and Arc-Check for dosimetric verification in patients treaties with IMRT; Evaluacion comparativa de MapCHECK y ArcCHECK para verificacion dosimetrica en pacientes tratados con IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, B.; Marquina, J.; Ramirez, J.; Gonzales, A., E-mail: bertha.garcia@aliada.com.pe [ALIADA, Oncologia Integral, Av. Jose Galvez Barrenechea 1044, San Isidro, Lima 27 (Peru)

    2014-08-15

    The dosimetric controls that are realized to the patients in the Intensity-Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) techniques; are indispensable since allows in real time to verify the quantity of imparted dose to the patient, these controls should be carried out every time that will begin a treatment, because these techniques impart dose dynamically modulating the dose intensity and movements of the Multi leaf Collimator (MLC), for they exist different diodes devices prepared in spiral (3-D) and planar form (2-D); that allows to estimate the dose fluence in a certain area. Treatment studies for head and neck with IMRT were compared regarding the reading average carried out by the diodes in the corresponding areas, using the criteria of the gamma index like dose difference 3% or 3m m of distance for both diode arrangements, in the IMRT case was found in Arc-Check a minor difference of 3/3 for an average of 99.37% of read diodes in a correct way contrary to the reading obtained with the Map-Check 3/3 an average of difference of 96.19%; in IMRT the difference was lower due to different factors like sensibility of the diodes reading, resolution, diodes disposition, as well as the average reading of entrance and exit of the radiation beams. Within the parameters delivered by the diodes arrangement is considered the positioning correction for both acceptance indexes like the gamma factor and the Distance-to-agreement (Dta), the existent difference of reading in factor gamma and Dta fundamentally is the way in like they compare the dose distribution; the Gamma uses dose averages of high and low gradients and Dta use only averages of areas of high gradients between the nearest points giving the distance as a result among the distribution point and the nearest point what makes stricter. (Author)

  11. A conceptual model of check dam hydraulics for gully control

    Directory of Open Access Journals (Sweden)

    C. Castillo

    2013-09-01

    Full Text Available There is little information in scientific literature regarding the modifications induced by check dam systems in flow regimes in restored gully reaches, despite it being a crucial issue for the design of conservation measures. Here, we develop a conceptual model to classify flow regimes in straight rectangular channels for initial and dam-filling conditions as well as a method of estimating efficiency in order to provide guidelines for optimal design. The model integrates several previous mathematical approaches for assessing the main processes involved (hydraulic jump HJ, impact flow, gradually varied flows. Its performance was compared with the simulations obtained from IBER, a bi-dimensional hydrodynamic model. The impact of check dam spacing (defined by the geometric factor of influence c on efficiency was explored. Eleven main classifications of flow regimes were identified depending on the element and level of influence. The model produced similar results when compared with IBER, but led to higher estimations of HJ and impact lengths. Total influence guaranteed maximum efficiency and HJ control defining the location of the optimal c. Geometric total influence (c = 1 was a valid criterion for the different stages of the structures in a wide range of situations provided that hydraulic roughness conditions remained high within the gully, e.g. through revegetation. Our total influence criterion involved shorter spacing than that habitually recommended in technical manuals for restoration, but was in line with those values found in spontaneous and stable step-pools systems, which might serve as a reference for man-made interventions.

  12. Applicability of refractometry for fast routine checking of hospital preparations.

    Science.gov (United States)

    Hendrickx, Stijn; Verón, Aurora Monteagudo; Van Schepdael, Ann; Adams, Erwin

    2016-04-30

    Quality control of hospital pharmacy formulations is of the utmost importance to ensure constant quality and to avoid potential mistakes before administration to the patient. In this study we investigated the applicability of refractometry as a fast, inexpensive and easy-to-use quality control measurement. Refractive indices (RI) of a multitude of different hospital formulations with varying concentrations of active compound were measured. The samples consisted of a number of binary aqueous solutions (one compound in water), complex aqueous solutions (multiple compounds in water or in a constant matrix), two suspensions and one emulsion. For all these formulations, linear regression analysis was performed, quality control limits determined and accuracy and repeatability were checked. Subsequently, actual hospital pharmacy samples were analyzed to check whether they were within the specified limits. For both binary and complex aqueous formulations, repeatability was good and a linear correlation for all samples could be observed on condition that the concentration of the active compound was sufficiently high. The refractometer was not sensitive enough for solutions of folic acid and levothyroxine, which had too low a concentration of active compound. Due to lack of homogeneity and light scattering, emulsions and suspensions do not seem suitable for quality control by refractometry. A mathematical equation was generated to predict the refractive index of an aqueous solution containing clonidine HCl as active compound. Values calculated from the equation were compared with measured values and deviations of all samples were found to be lower than 1.3%. In order to use refractometry in a hospital pharmacy for quality control of multicomponent samples, additional intermediate measurements would be required, to overcome the fact that refractometry is not compound specific. In conclusion, we found that refractometry could potentially be useful for daily, fast quality

  13. Analysis of DIRAC's behavior using model checking with process algebra

    International Nuclear Information System (INIS)

    DIRAC is the grid solution developed to support LHCb production activities as well as user data analysis. It consists of distributed services and agents delivering the workload to the grid resources. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check and possibly react to changes in the system state. Each agent's logic is relatively simple; the main complexity lies in their cooperation. Agents run concurrently, and collaborate using the databases as shared memory. The databases can be accessed directly by the agents if running locally or through a DIRAC service interface if necessary. This shared-memory model causes entities to occasionally get into inconsistent states. Tracing and fixing such problems becomes formidable due to the inherent parallelism present. We propose more rigorous methods to cope with this. Model checking is one such technique for analysis of an abstract model of a system. Unlike conventional testing, it allows full control over the parallel processes execution, and supports exhaustive state-space exploration. We used the mCRL2 language and toolset to model the behavior of two related DIRAC subsystems: the workload and storage management system. Based on process algebra, mCRL2 allows defining custom data types as well as functions over these. This makes it suitable for modeling the data manipulations made by DIRAC's agents. By visualizing the state space and replaying scenarios with the toolkit's simulator, we have detected race-conditions and deadlocks in these systems, which, in several cases, were confirmed to occur in the reality. Several properties of interest were formulated and verified with the tool. Our future direction is automating the translation from DIRAC to a formal model.

  14. IMPORTANCE OF PERIODIC HEALTH CHECK UP FOR INDIAN WOMEN

    Directory of Open Access Journals (Sweden)

    Avtar Singh

    2014-07-01

    Full Text Available OBJECTIVE: In the past women’s health care services were focused mainly on the health problems during pregnancy and childbirth. Although these are major contributors of morbidity and mortality in women life and require to be addressed in correct perspective, but at the same time the question arises that why should women’s health remain limited to traditional Maternal and Child Health issues, as they are also exposed to strong risks of lifestyle diseases and specific conditions like certain cancers, anaemia, besides hazards of pregnancy/ child birth. Due largely to asymptomatic nature of these conditions, women may not be aware that they are at risk for non-communicable diseases, therefore screening for these diseases are important for assessing risk of future medical problems and to encourage a healthy lifestyle by women. MATERIAL AND METHODS: At the outset, to sensitize the women regarding importance of health check-up, health awareness campaign was run, followed by health examination including anthropometry, general medical checkup, blood tests for haemoglobin, blood sugar, ( Random, serum cholesterol, urine test for albumin and sugar, clinical breast examination for presence of lump and PAP smear for cervical cancer. Subjects with abnormal results were counseled by counselor and referred for further managements. SAMPLING: 1760 females married to Armed Forces personnel between the ages of 22 years to 55 years of age were selected for screening excluding pregnant women. 1384 women participated in the study. RESULTS: The prevalence of various parameters studied was comparable to national figures and other studies. CONCLUSION: Results suggest that women are vulnerable to lifestyle diseases, certain cancers and non-communicable diseases. Strict preventive measures and health education is mandatory to limit this menace; a formalized periodic health check up for women in different age groups is strongly recommended.

  15. Analysis of DIRAC's behavior using model checking with process algebra

    Science.gov (United States)

    Remenska, Daniela; Templon, Jeff; Willemse, Tim; Bal, Henri; Verstoep, Kees; Fokkink, Wan; Charpentier, Philippe; Graciani Diaz, Ricardo; Lanciotti, Elisa; Roiser, Stefan; Ciba, Krzysztof

    2012-12-01

    DIRAC is the grid solution developed to support LHCb production activities as well as user data analysis. It consists of distributed services and agents delivering the workload to the grid resources. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check and possibly react to changes in the system state. Each agent's logic is relatively simple; the main complexity lies in their cooperation. Agents run concurrently, and collaborate using the databases as shared memory. The databases can be accessed directly by the agents if running locally or through a DIRAC service interface if necessary. This shared-memory model causes entities to occasionally get into inconsistent states. Tracing and fixing such problems becomes formidable due to the inherent parallelism present. We propose more rigorous methods to cope with this. Model checking is one such technique for analysis of an abstract model of a system. Unlike conventional testing, it allows full control over the parallel processes execution, and supports exhaustive state-space exploration. We used the mCRL2 language and toolset to model the behavior of two related DIRAC subsystems: the workload and storage management system. Based on process algebra, mCRL2 allows defining custom data types as well as functions over these. This makes it suitable for modeling the data manipulations made by DIRAC's agents. By visualizing the state space and replaying scenarios with the toolkit's simulator, we have detected race-conditions and deadlocks in these systems, which, in several cases, were confirmed to occur in the reality. Several properties of interest were formulated and verified with the tool. Our future direction is automating the translation from DIRAC to a formal model.

  16. Application of the Farr assay to the analysis of antibodies specific for UV irradiated DNA

    International Nuclear Information System (INIS)

    In order to determine the optimum conditions for reactivity in the ammonium sulphate precipitation (Farr) assay the authors have studied the DNA binding properties of two antibodies raised against ultraviolet single stranded DNA (UVssDNA) complexed with methylated bovine serum albumin. In general the buffer composition, pH, temperature, and ionic strength conditions described for binding to undamaged DNA were found to be appropriate for binding to UV-irradiated DNA. However, some differences in detail were noted which indicate the necessity for checking the physical conditions of binding of individual antibodies. Mouse monoclonal antibody and rabbit polyclonal antisera bound to UVssDNA very rapidly, even when DNA and ammonium sulphate were added simultaneously, whereas this procedure prevented binding of rabbit antisera to UV-irradiated double stranded DNA. Incubation at 450 C for 30 min inhibited binding by mouse antibody, and incubation at 370 C for 60 min caused reversible dissociation of the DNA-antibody complex. The optimised Farr assay was used to define the antigen specificities of the antibodies. (Auth.)

  17. Antibody fragments: Hope and hype

    OpenAIRE

    Nelson, Aaron L

    2010-01-01

    The antibody molecule is modular and separate domains can be extracted through biochemical or genetic means. It is clear from review of the literature that a wave of novel, antigen-specific molecular forms may soon enter clinical evaluation. This report examines the developmental histories of therapeutics derived from antigen-specific fragments of antibodies produced by recombinant processes. Three general types of fragments were observed, antigen-binding fragments (Fab), single chain variabl...

  18. Functional effects of anticardiolipin antibodies.

    Science.gov (United States)

    Harris, E N; Pierangeli, S S

    1996-10-01

    The 'lupus anticoagulant' phenomenon is the best documented functional effect of antiphospholipid (aPL) antibodies, occurring either by inhibition of the prothrombinase and/or Factor X activation reactions. Understanding the mechanism by which aPL antibodies inhibit phospholipid dependent coagulation reactions may yield important clues about their 'thrombogenic effects' in vivo. We conducted a series of studies to determine the specificity, diversity, and mechanism by which aPL antibodies inhibit phospholipid dependent reactions. Results showed that purified immunoglobulins with lupus anticoagulant and anti-cardiolipin activities were absorbed by negatively charged phospholipids and both activities were recovered from the phospholipid-antibody precipitate. Purified aPL antibodies inhibited the prothrombinase reaction in a plasma free system in which beta 2-glycoprotein 1 (beta 2-GP1) was absent. Affinity purified aPL antibodies had 25-50 times the inhibitory activity of immunoglobulin preparations. The phospholipid binding proteins, beta 2-GPI and placental anticoagulant protein I (PAP I), independently inhibited the prothrombinase reaction, and when these proteins were combined with aPL, inhibition of the prothrombinase reaction was additive. Antibodies of syphilis had no inhibitory effect, partially accounted for by lack of specificity for phosphotidylserine (PS). Although aPL antibodies inhibited the protein C activation reaction, there was no correlation of these activities with inhibition of the prothrombinase reaction. Together, these results show that aPL exert their effects by interaction with negatively charged phospholipids, in particular phosphotidylserine, but lack of correlation between inhibition of the prothrombinase and protein C activation reactions, suggests that the nature of the coagulation protein is also important. PMID:8902763

  19. The antineutrophil antibody in uveitis.

    OpenAIRE

    Young, D W

    1991-01-01

    Ninety eight patients with uveitis of various types were tested for the presence of the antineutrophil antibody or ANCA by an indirect immunofluorescence method. This antibody is found in patients with diseases associated with small vessel vasculitis, including Wegener's granulomatosis and microscopic polyarteritis. Eleven true positive cases were found. A positive test was not associated with the anatomical site of the uveitis but was related to the time course of the disease. In particular ...

  20. Interfacial metal and antibody recognition

    OpenAIRE

    Zhou, Tongqing; Hamer, Dean H.; Hendrickson, Wayne A.; Sattentau, Quentin J.; Kwong, Peter D.

    2005-01-01

    The unique ligation properties of metal ions are widely exploited by proteins, with approximately one-third of all proteins estimated to be metalloproteins. Although antibodies use various mechanisms for recognition, to our knowledge, none has ever been characterized that uses an interfacial metal. We previously described a family of CD4-reactive antibodies, the archetype being Q425. CD4:Q425 engagement does not interfere with CD4:HIV-1 gp120 envelope glycoprotein binding, but it blocks subse...

  1. Pyoderma gangrenosum and anticardiolipin antibody

    Directory of Open Access Journals (Sweden)

    de Godoy Jose Maria

    2006-01-01

    Full Text Available Pyoderma gangrenosum (PG is a rare ulceronecrotic inflammatory cutaneous disorder and is frequently associated with systemic diseases. The authors report a 22-year-old male patient with pyoderma gangrenosum, thrombosis of both popliteal arteries, ischemic stroke and seropositivity for anticardiolipin antibody. Despite intravenous treatment with antibiotics, corticosteroid and heparin, pyoderma gangrenosum caused necrosis of his right lower limb which resulted in amputation. It was concluded that the anticardiolipin antibody may have contributed to the gravity of this case.

  2. Antibodies to watch in 2014.

    Science.gov (United States)

    Reichert, Janice M

    2014-01-01

    Since 2010, mAbs has documented the biopharmaceutical industry's progress in transitioning antibody therapeutics to first Phase 3 clinical studies and regulatory review, and its success at gaining first marketing approvals for antibody-based products. This installment of the "Antibodies to watch" series outlines events anticipated to occur between December 2013 and the end of 2014, including first regulatory actions on marketing applications for vedolizumab, siltuximab, and ramucirumab, as well as the Fc fusion proteins Factor IX-Fc and Factor VIII-Fc; and the submission of first marketing applications for up to five therapeutics (secukinumab, ch14.18, onartuzumab, necitumumab, gevokizumab). Antibody therapeutics in Phase 3 studies are described, with an emphasis on those with study completion dates in 2014, including antibodies targeting interleukin-17a or the interleukin-17a receptor (secukinumab, ixekizumab, brodalumab), proprotein convertase subtilisin/kexin type 9 (alirocumab, evolocumab, bococizumab), and programmed death 1 receptor (lambrolizumab, nivolumab). Five antibodies with US Food and Drug Administration's Breakthrough Therapy designation (obinutuzumab, ofatumumab, lambrolizumab, bimagrumab, daratumumab) are also discussed. PMID:24284914

  3. Tabhu: tools for antibody humanization.

    KAUST Repository

    Olimpieri, Pier Paolo

    2014-10-09

    SUMMARY: Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to recognize their cognate antigens with high specificity and affinity, and a high yield at reasonable costs in model animals. Unfortunately, when administered to human patients, xenogeneic antibodies can elicit unwanted and dangerous immunogenic responses. Antibody humanization methods are designed to produce molecules with a better safety profile still maintaining their ability to bind the antigen. This can be accomplished by grafting the non-human regions determining the antigen specificity into a suitable human template. Unfortunately, this procedure may results in a partial or complete loss of affinity of the grafted molecule that can be restored by back-mutating some of the residues of human origin to the corresponding murine ones. This trial-and-error procedure is hard and involves expensive and time-consuming experiments. Here we present tools for antibody humanization (Tabhu) a web server for antibody humanization. Tabhu includes tools for human template selection, grafting, back-mutation evaluation, antibody modelling and structural analysis, helping the user in all the critical steps of the humanization experiment protocol. AVAILABILITY: http://www.biocomputing.it/tabhu CONTACT: anna.tramontano@uniroma1.it, pierpaolo.olimpieri@uniroma1.it SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

  4. Avian Diagnostic and Therapeutic Antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, David Sherman [UND SMHS

    2012-12-31

    A number of infectious agents have the potential of causing significant clinical symptomology and even death, but dispite this, the number of incidence remain below the level that supports producing a vaccine. Therapeutic antibodies provide a viable treatment option for many of these diseases. We proposed that antibodies derived from West Nile Virus (WNV) immunized geese would be able to treat WNV infection in mammals and potential humans. We demonstrated that WNV specific goose antibodies are indeed successful in treating WNV infection both prophylactically and therapeutically in a golden hamster model. We demonstrated that the goose derived antibodies are non-reactogenic, i.e. do not cause an inflammatory response with multiple exposures in mammals. We also developed both a specific pathogen free facility to house the geese during the antibody production phase and a patent-pending purification process to purify the antibodies to greater than 99% purity. Therefore, the success of these study will allow a cost effective rapidly producible therapeutic toward clinical testing with the necessary infrastructure and processes developed and in place.

  5. Radiolabeled monoclonal antibodies: a review

    International Nuclear Information System (INIS)

    Since the description by Kohler and Milstein 1975 of their technique for producing monoclonal antibodies of predefined specificity, it has become a mainstay in most laboratories that utilize immunochemical techniques to study problems in basic, applied or clinical research. Paradoxically, the very success of monoclonal antibodies has generated a literature which is now so vast and scattered that it has become difficult to obtain a perspective. This brief review represents the distillation of many publications relating to the production and use of monoclonaal antibodies as radiopharmaceuticals. Significant advances were made possible in the last few years by combined developments in the fields of tumor-associated antigens and of monoclonal antibodies. In fact monoclonal antibodies against some well defined tumor-associated antigens, has led to significantly greater practical possibilities for producing highly specific radiolabeled antibodies as radiopharmaceuticals for diagnosis and therapy of human tumors. One of the main requirements of this methodology is the availability of stable radiopharmaceutical reagents which after labeling in vivo injection retain the capacity of specific interaction with the defined antigen and their molecular integrity. Since injection into human is the objetive of this kind of study all the specifications of radiopharmaceutical have to be fulfilled e.g. sterility, apirogenicity and absence of toxicity. (author)

  6. Radioimmunoguided surgery using monoclonal antibody

    International Nuclear Information System (INIS)

    The potential proficiency of radioimmunoguided surgery in the intraoperative detection of tumors was assessed using labeled monoclonal antibody B72.3 in 66 patients with tissue-proved tumor. Monoclonal antibody B72.3 was injected 5 to 42 days preoperatively, and the hand-held gamma-detecting probe was used intraoperatively to detect the presence of tumor. Intraoperative probe counts of less than 20 every 2 seconds, or tumor-to-adjacent normal tissue ratios less than 2:1 were considered negative (system failure). Positive probe counts were detected in 5 of 6 patients with primary colon cancer (83 percent), in 31 of 39 patients with recurrent colon cancer (79 percent), in 4 of 5 patients with gastric cancer (80 percent), in 3 of 8 patients with breast cancer (37.5 percent), and in 4 of 8 patients with ovarian cancer (50 percent) undergoing second-look procedures. Additional patients in each group were scored as borderline positive. Overall, radioimmunoguided surgery using B72.3 identified tumors in 47 patients (71.2 percent), bordered on positive in 6 patients (9.1 percent), and failed to identify tumor in 13 patients (19.7 percent). Improved selection of patients for antigen-positive tumors, the use of higher affinity second-generation antibodies, alternate routes of antibody administration, alternate radionuclides, and more sophisticatedly bioengineered antibodies and antibody combinations should all lead to improvements in radioimmunoguided surgery

  7. Monoclonal antibodies technology. Protocols

    International Nuclear Information System (INIS)

    Full text: Immunization. The first step in preparing useful monoclonal antibodies (MAbs) is to immunize an animal (Balb/c for example) with an appropriate antigen. Methods (only for soluble antigen): Solubilize selected antigen in Phosphate buffer solution (PBS) at pH 7.2-7.4, ideally at a final concentration per animal between 10 to 50 μg/ml. It is recommended that the antigen under consideration be incorporated into the emulsion adjuvants in 1:1 volumetric relation. We commonly use Frend's adjuvant (FA) to prepared immunized solution. The first immunization should be prepared with complete FA, and the another could be prepared with incomplete FA. It is recommended to inject mice with 0.2 ml intraperitoneal (ip) or subcutaneous (sc). Our experience suggests the sc route is the preferred route. A minimum protocol for immunizing mice to generate cells for preparing hybridomas is s follows: immunize sc on day 0, boost sc on day 21, take a trial bleeding on day 26; if antibody titters are satisfactory, boost ip on day 35 with antigen only, and remove the spleen to obtain cells for fusion on day 38. Fusion protocol. The myeloma cell line we are using is X63 Ag8.653. At the moment of fusion myeloma cells need a good viability (at least a 95%). 1. Remove the spleen cells from immunized mice using sterile conditions. An immune spleen should yield between 7 a 10x107 nucleated cells. 2. Place the spleen in 20 ml of serum-free RPMI 1640 in a Petri dish. Using a needle and syringe, inject the spleen with medium to distend and disrupt the spleen stroma and free the nucleated cells. 3. Flush the cell suspension with a Pasteur pipet to disperse clumps of cells. 4. Centrifuge the spleen cell suspension at 250g for 10 min. Resuspend the pellet in serum-free RPMI 1640. Determine cell concentration using Neuhabuer chamber. 5. Mix the myeloma cells and spleen cells in a conical 50-ml tube in serum-free RPMI 1640, 1 x107 spleen cells to 1x106 myeloma cells (ratio 10:1). Centrifuge

  8. Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid.

    Science.gov (United States)

    Lee, Jee-Hoon; Kang, Ik-Jae; Kim, A-Reum; Noh, You-Sun; Chung, Hee-Chun; Park, Bong-Kyun

    2016-06-30

    This study was conducted to determine if humoral antibody response of foot-and-mouth disease (FMD) vaccine improved in 8-week-old growing pigs born to well-vaccinated sows pre-treated with 60 mg of poly-γ-glutamic acid (γ-PGA) three days before vaccination. Antibody against FMD virus serotype O was measured 0, 2, 4 and 6 weeks post-vaccination, using a PrioCHECK FMDV type O ELISA kit. The results showed that positive antibody reactions against FMDV serotype O antigen among a component of the vaccine significantly increased in response to pre-injection with γ-PGA. PMID:26645341

  9. Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid

    Science.gov (United States)

    Lee, Jee-Hoon; Kang, Ik-Jae; Kim, A-Reum; Noh, You-Sun; Chung, Hee-Chun

    2016-01-01

    This study was conducted to determine if humoral antibody response of foot-and-mouth disease (FMD) vaccine improved in 8-week-old growing pigs born to well-vaccinated sows pre-treated with 60 mg of poly-γ-glutamic acid (γ-PGA) three days before vaccination. Antibody against FMD virus serotype O was measured 0, 2, 4 and 6 weeks post-vaccination, using a PrioCHECK FMDV type O ELISA kit. The results showed that positive antibody reactions against FMDV serotype O antigen among a component of the vaccine significantly increased in response to pre-injection with γ-PGA. PMID:26645341

  10. Emodnet Med Sea Check-Point - Indicators for decision- maker

    Science.gov (United States)

    Besnard, Sophie; Claverie, Vincent; Blanc, Frédérique

    2015-04-01

    The Emodnet Checkpoint projects aim is to assess the cost-effectiveness, reliability and utility of the existing monitoring at the sea basin level. This involves the development of monitoring system indicators and a GIS Platform to perform the assessment and make it available. Assessment or production of Check-Point information is made by developing targeted products based on the monitoring data and determining whether the products are meeting the needs of industry and public authorities. Check-point users are the research community, the 'institutional' policy makers for IMP and MSFD implementation, the 'intermediate users', i.e., users capable to understand basic raw data but that benefit from seeing the Checkpoint targeted products and the assessment of the fitness for purpose. We define assessment criteria aimed to characterize/depict the input datasets in terms of 3 territories capable to show performance and gaps of the present monitoring system, appropriateness, availability and fitness for purpose. • Appropriateness: What is made available to users? What motivate/decide them to select this observation rather than this one. • Availability: How this is made available to the user? Place to understand the readiness and service performance of the EU infrastructure • Fitness for use / fitness for purpose: Ability for non-expert user to appreciate the data exploitability (feedback on efficiency & reliability of marine data) For each territory (appropriateness, Availability and Fitness for purpose / for use), we define several indicators. For example, for Availability we define Visibility, Accessibility and Performance. And Visibility is itself defined by "Easily found" and "EU service". So these indicators can be classified according to their territory and sub-territory as seen above, but also according to the complexity to build them. Indicators are built from raw descriptors in 3 stages:  Stage 1: to give a neutral and basic status directly computed from

  11. Production of recombinant antibodies using bacteriophages

    OpenAIRE

    Shukra, A. M.; Sridevi, N. V.; Dev Chandran,; Kapil Maithal,

    2014-01-01

    Recombinant antibody fragments such as Fab, scFv, diabodies, triabodies, single domain antibodies and minibodies have recently emerged as potential alternatives to monoclonal antibodies, which can be engineered using phage display technology. These antibodies match the strengths of conventionally produced monoclonal antibodies and offer advantages for the development of immunodiagnostic kits and assays. These fragments not only retain the specificity of the whole monoclonal ...

  12. Antibody-Directed Phototherapy (ADP

    Directory of Open Access Journals (Sweden)

    M. Adil Butt

    2013-04-01

    Full Text Available Photodynamic therapy (PDT is a clinically-approved but rather under-exploited treatment modality for cancer and pre-cancerous superficial lesions. It utilises a cold laser or LED to activate a photochemical reaction between a light activated drug (photosensitiser-drug and oxygen to generate cytotoxic oxygen species. These free radical species damage cellular components leading to cell death. Despite its benefits, the complexity, limited potency and side effects of PDT have led to poor general usage. However, the research area is very active with an increasing understanding of PDT-related cell biology, photophysics and significant progress in molecular targeting of disease. Monoclonal antibody therapy is maturing and the next wave of antibody therapies includes antibody-drug conjugates (ADCs, which promise to be more potent and curable. These developments could lift antibody-directed phototherapy (ADP to success. ADP promises to increase specificity and potency and improve drug pharmacokinetics, thus delivering better PDT drugs whilst retaining its other benefits. Whole antibody conjugates with first generation ADP-drugs displayed problems with aggregation, poor pharmacokinetics and loss of immuno-reactivity. However, these early ADP-drugs still showed improved selectivity and potency. Improved PS-drug chemistry and a variety of conjugation strategies have led to improved ADP-drugs with retained antibody and PS-drug function. More recently, recombinant antibody fragments have been used to deliver ADP-drugs with superior drug loading, more favourable pharmacokinetics, enhanced potency and target cell selectivity. These improvements offer a promise of better quality PDT drugs.

  13. Grab Windows training opportunities; check CERN Windows roadmap!

    CERN Multimedia

    IT Department

    2011-01-01

    CERN Operating Systems and Information Services group (IT-OIS) actively monitors market trends to check how new software products correspond to CERN needs. In the Windows world, Windows 7 has been a big hit, with over 1500 Windows 7 PCs within less than a year since its support was introduced at CERN. No wonder: Windows XP is nearly 10 years old and is steadily approaching the end of its life-cycle. At CERN, support for Windows XP will stop at the end of December 2012. Compared to Vista, Windows 7 has the same basic hardware requirements, but offers higher performance, so the decision to upgrade is rather straightforward. CERN support for Vista will end in June 2011. In the world of Microsoft Office, version 2007 offers better integration with the central services than the older version 2003. Progressive upgrade from 2003 to 2007 is planned to finish in September 2011, but users are encouraged to pro-actively upgrade at their convenience. Please note that Office 2007 brings an important change in the area of ...

  14. Selecting Female Mice in Estrus and Checking Plugs.

    Science.gov (United States)

    Behringer, Richard; Gertsenstein, Marina; Nagy, Kristina Vintersten; Nagy, Andras

    2016-01-01

    The female mouse estrous cycle is divided into four phases: proestrus (development of ovarian follicles), estrus (ovulation), metestrus (formation of corpora lutea), and diestrus (beginning of follicle development for next ovulation and elimination of previous oocytes). The appearance of the epithelium of the external genitalia is used to identify the stage of the estrous cycle of a female mouse. This is usually easier to see in strains with either no or only light skin pigmentation. By examining the color, moistness, and degree of swelling of the vagina, females in estrus can readily be identified. To set up the matings, females are examined in the afternoon, and those in estrus are placed into the cages with males (one or two females in each cage with one male). Usually, 50% or more of the selected females will mate. The presence of a vaginal copulation plug next morning indicates that mating has occurred, but it does not mean that a pregnancy will result even if proven breeder fertile males were used. It is important to check vaginal plugs early in the morning because they fall out or are no longer detectable ~12 h after mating or sometimes earlier. PMID:27480722

  15. Structure-Based Deadlock Checking of Asynchronous Circuits

    Institute of Scientific and Technical Information of China (English)

    Hong-Guang Ren; Zhi-Ying Wang; Doug Edwards

    2011-01-01

    It is important to verify the absence of deadlocks in asynchronous circuits.Much previous work relies on a reachability analysis of the circuits' states,with the use of binary decision diagrams (BDDs) or Petri nets to model the behaviors of circuits.This paper presents an alternative approach focusing on the structural properties of well-formed asynchronous circuits that will never suffer deadlocks.A class of data-driven asynchronous pipelines is targeted in this paper,which can be viewed as a network of basic components connected by handshake channels.The sufficient and necessary conditions for a component network consisting of Steer,Merge,Fork and Join are given.The slack elasticity of the channels is analyzed in order to introduce pipelining.As an application,a deadlock checking method is implemented in a syntax-directed asynchronous design tool - Teak.The proposed method shows a great runtime advantage when compared against previous Petri net based verification tools.

  16. Analysis of the Security of BB84 by Model Checking

    Directory of Open Access Journals (Sweden)

    Mohamed Elboukhari

    2010-04-01

    Full Text Available Quantum Cryptography or Quantum key distribution (QKD is a technique that allows the secure distribution of a bit string, used as key in cryptographic protocols. When it was noted that quantum computers could break public key cryptosystems based on number theory extensive studies have been undertaken on QKD. Based on quantum mechanics, QKD offers unconditionally secure communication. Now, the progress of research in this field allows the anticipation of QKD to be available outside of laboratories within the next few years. Efforts are made to improve the performance and reliability of the implemented technologies. But several challenges remain despite this big progress. The task of how to test the apparatuses of QKD For example did not yet receive enough attention. These devises become complex and demand a big verification effort. In this paper we are interested in an approach based on the technique of probabilistic model checking for studying quantum information. Precisely, we use the PRISM tool to analyze the security of BB84 protocol and we are focused on the specific security property of eavesdropping detection. We show that this property is affected by the parameters of quantum channel and the power of eavesdropper

  17. Systematics for checking geometric errors in CNC lathes

    Science.gov (United States)

    Araújo, R. P.; Rolim, T. L.

    2015-10-01

    Non-idealities presented in machine tools compromise directly both the geometry and the dimensions of machined parts, generating distortions in the project. Given the competitive scenario among different companies, it is necessary to have knowledge of the geometric behavior of these machines in order to be able to establish their processing capability, avoiding waste of time and materials as well as satisfying customer requirements. But despite the fact that geometric tests are important and necessary to clarify the use of the machine correctly, therefore preventing future damage, most users do not apply such tests on their machines for lack of knowledge or lack of proper motivation, basically due to two factors: long period of time and high costs of testing. This work proposes a systematics for checking straightness and perpendicularity errors in CNC lathes demanding little time and cost with high metrological reliability, to be used on factory floors of small and medium-size businesses to ensure the quality of its products and make them competitive.

  18. Use of statistical checks as maintenance tools for TLD readers

    International Nuclear Information System (INIS)

    Background signals, which are non-radiation related, are produced during the readout process in the TL reader systems. The source of these signals can be the reader itself or effects in the TL crystal. The TL signal is received during the heating process by applying a defined temperature profile. The photomultiplier converts the light accumulated to current that is translated to dose according to calibration parameters. If during the accumulation process additional light or current sources are present, these contributions will be added to the exposure induced data. In order to ensure an accurate and reliable operation of the reader, the background sources must be monitored continuously, and proper calibration of the system must be performed. However, there may be small drifts, or background signals covered by fluctuation processes, that may remain undetected. We propose some statistical checks of system parameters which may give a broader insight into the operational characteristics of the TLD reader and may help for proper maintenance of the system

  19. Using surface integrals for checking the Archimedes' law of buoyancy

    CERN Document Server

    Lima, F M S

    2011-01-01

    A mathematical derivation of the force exerted by an \\emph{inhomogeneous} (i.e., compressible) fluid on the surface of an \\emph{arbitrarily-shaped} body immersed in it is not found in literature, which may be attributed to our trust on Archimedes' law of buoyancy. However, this law, also known as Archimedes' principle (AP), does not yield the force observed when the body is in contact to the container walls, as is more evident in the case of a block immersed in a liquid and in contact to the bottom, in which a \\emph{downward} force that \\emph{increases with depth} is observed. In this work, by taking into account the surface integral of the pressure force exerted by a fluid over the surface of a body, the general validity of AP is checked. For a body fully surrounded by a fluid, homogeneous or not, a gradient version of the divergence theorem applies, yielding a volume integral that simplifies to an upward force which agrees to the force predicted by AP, as long as the fluid density is a \\emph{continuous func...

  20. Development of sensors for checking corrosion processes in reinforced concrete

    International Nuclear Information System (INIS)

    Argentina's National Atomic Energy Commission is responsible for developing a program for the management of radioactive wastes. This program includes, among other activities, the design and construction of a facility for the final disposal of half-life radioactive wastes. The model consists of the use of multiple, redundant and independent barriers, including the container and its cover made of reinforced concrete. The useful life of these structures should be over 300 years, and to meet this requirement, quantitative information is needed about the coating properties and threshold values at the start of the corrosive process. This work presents the development of corrosion sensors for the on-line measurement of the corrosion potential, the corrosion current density of the structures, the flow of oxygen in the structures, the concrete's electrical resistance, its chloride content and the structure's internal temperature. These sensors, duly installed in a structure, check on the corrosive process. With this data the final design of the container can be prepared that will last as long or longer than that foreseen for this type of facility (CW)

  1. Temporal Check-All-That-Apply Characterization of Syrah Wine.

    Science.gov (United States)

    Baker, Allison K; Castura, John C; Ross, Carolyn F

    2016-06-01

    Temporal Check-All-That-Apply (TCATA) is a new dynamic sensory method for which analysis techniques are still being developed and optimized. In this study, TCATA methodology was applied for the evaluation of wine finish by trained panelists (n = 13) on Syrah wines with different ethanol concentrations (10.5% v/v and 15.5% v/v). Raw data were time standardized to create a percentage of finish duration, subsequently segmented into thirds (beginning, middle, and end) to capture panel perception. Results indicated the finish of the high ethanol treatments lasted longer (approximately 12 s longer) than the low ethanol treatment (P ≤ 0.05). Within each finish segment, Cochran's Q was conducted on each attribute and differences were detected amongst treatments (P ≤ 0.05). Pairwise tests showed the high ethanol treatments were more described by astringency, heat/ethanol burn, bitterness, dark fruit, and spices, whereas the low ethanol treatment was more characterized by sourness, red fruit, and green flavors (P ≤ 0.05). This study demonstrated techniques for dealing with the data generated by TCATA. Furthermore, this study further characterized the influence of ethanol on wine finish, and by extension wine quality, with implications to winemakers responsible for wine processing decisions involving alcohol management. PMID:27272248

  2. Dynamic Data Possession Checking for Secure Cloud Storage Service

    Directory of Open Access Journals (Sweden)

    Wenzhe Jiao

    2013-12-01

    Full Text Available Using cloud storage service, data owners can access their data anywhere at any time and enjoy the on-demand high quality applications and services, without the burden of local data storage and maintenance. Meanwhile, the risk of losing data stored with any untrustworthy service provider is the key barrier to widely adopt cloud storage service. To verify the integrity of data stored in cloud and relieve the security concerns of customers, a privacy-preserving data possession checking (DPC scheme is presented. This scheme uses Merkle Hash Tree to support fully dynamic data operations. To achieve robustness, forward error-correcting codes can be combined with the proposed DPC scheme, which can recover the data when a small amount of file has been corrupted. The scheme allows unlimited times verification without the need for the verifier to compare against the original data, which reduces the communication and computation complexity dramatically and preserves the privacy of the data. Extensive security analysis and simulation show that the proposed scheme is highly provably secure.

  3. Using surface integrals for checking Archimedes' law of buoyancy

    International Nuclear Information System (INIS)

    A mathematical derivation of the force exerted by an inhomogeneous (i.e. compressible) fluid on the surface of an arbitrarily shaped body immersed in it is not found in the literature, which may be attributed to our trust in Archimedes' law of buoyancy. However, this law, also known as Archimedes' principle (AP), does not yield the force observed when the body is in contact with the container walls, as is more evident in the case of a block immersed in a liquid and in contact with the bottom, in which a downward force that increases with depth is observed. In this work, by taking into account the surface integral of the pressure force exerted by a fluid over the surface of a body, the general validity of AP is checked. For a body fully surrounded by a fluid, homogeneous or not, a gradient version of the divergence theorem applies, yielding a volume integral that simplifies to an upward force which agrees with the force predicted by AP, as long as the fluid density is a continuous function of depth. For the bottom case, this approach yields a downward force that increases with depth, which contrasts to AP but is in agreement with experiments. It also yields a formula for this force which shows that it increases with the area of contact.

  4. Preventing the threat of credit-card fraud: Factors influencing cashiers' identification-checking behavior.

    Science.gov (United States)

    Downing, Christopher; Howard, E Henry; Goodwin, Christina; Geller, E Scott

    2016-01-01

    Two studies examined factors influencing cashiers' identification (ID)-checking behavior in order to inform the development of interventions to prevent credit-card fraud. In both studies, research assistants made credit purchases in various stores and noted the cashiers' ID-checking behavior. In the first study, the store type, whether the cashier swiped the credit/debit card, the amount of the purchase, and whether the credit/debit card was signed significantly influenced ID-checking behavior. In the second study, an A-B-A design was used to evaluate the impact of a "Check my ID" prompt placed on the credit/debit card. The prompt increased cashiers' ID-checking behavior from 5.9% at Baseline to 10.3% during the Intervention. When the prompt was removed, the cashiers' ID-checking behavior decreased to 7.2%. Implications for further intervention research to prevent credit-card fraud are discussed. PMID:27309026

  5. The Design of E-Traveler’s Check with Efficiency and Mutual Authentication

    Directory of Open Access Journals (Sweden)

    Chin-Chen Chang

    2010-03-01

    Full Text Available Nowadays, traveling has become a popular leisure activity in our daily lives. Travelers can either use cash or credit cards to pay their bills. However, there is risk of cash being robbed or credit cards being copied. The traveler’s check, which is a third choice, comes in to get travelers around such risks and to protect their rights. Nevertheless, traditional travelers’ checks cannot keep imposters from forging and cashing them illegally. Hence, we propose a new type of check, called the e-traveler’s check, to preserve the rights of holders of e-traveler’s check and to prevent the check-issuing banks from being damaged.

  6. Risk and Scope of Debit Check Card in Competitive Market of Pakistan

    OpenAIRE

    Ali Zaidi, Syed Najaf; Ali, Syed Babar

    2006-01-01

    Today, even the smallest of transactions, from fast food to digital content, are attracting Debit Check cardholders, and more and more merchants are opening their doors to this burgeoning payment method. The topic for this dissertation is to review the Debit Card marketplace, culminating in addressing the question “What is the scope of new Debit check cards?” The literature review indicates that there are developing opportunities within the marketplace that could offer the Debit Check Card pr...

  7. SU-D-BRD-03: Improving Plan Quality with Automation of Treatment Plan Checks

    International Nuclear Information System (INIS)

    Purpose: To evaluate the effectiveness of an automated plan check tool to improve first-time plan quality as well as standardize and document performance of physics plan checks. Methods: The Plan Checker Tool (PCT) uses the Eclipse Scripting API to check and compare data from the treatment planning system (TPS) and treatment management system (TMS). PCT was created to improve first-time plan quality, reduce patient delays, increase efficiency of our electronic workflow, and to standardize and partially automate plan checks in the TPS. A framework was developed which can be configured with different reference values and types of checks. One example is the prescribed dose check where PCT flags the user when the planned dose and the prescribed dose disagree. PCT includes a comprehensive checklist of automated and manual checks that are documented when performed by the user. A PDF report is created and automatically uploaded into the TMS. Prior to and during PCT development, errors caught during plan checks and also patient delays were tracked in order to prioritize which checks should be automated. The most common and significant errors were determined. Results: Nineteen of 33 checklist items were automated with data extracted with the PCT. These include checks for prescription, reference point and machine scheduling errors which are three of the top six causes of patient delays related to physics and dosimetry. Since the clinical roll-out, no delays have been due to errors that are automatically flagged by the PCT. Development continues to automate the remaining checks. Conclusion: With PCT, 57% of the physics plan checklist has been partially or fully automated. Treatment delays have declined since release of the PCT for clinical use. By tracking delays and errors, we have been able to measure the effectiveness of automating checks and are using this information to prioritize future development. This project was supported in part by P01CA059827

  8. Model Checking Classes of Metric LTL Properties of Object-Oriented Real-Time Maude Specifications

    OpenAIRE

    Erika Ábrahám; Peter Csaba Ölveczky; Daniela Lepri

    2010-01-01

    This paper presents a transformational approach for model checking two important classes of metric temporal logic (MTL) properties, namely, bounded response and minimum separation, for nonhierarchical object-oriented Real-Time Maude specifications. We prove the correctness of our model checking algorithms, which terminate under reasonable non-Zeno-ness assumptions when the reachable state space is finite. These new model checking features have been integrated into Real-Time Maude, and are use...

  9. Risk and Scope of Debit Check Card in Competitive Market of Pakistan

    OpenAIRE

    Ali Zaidi, Syed Najaf; Ali, Syed Babar

    2006-01-01

    Today, even the smallest of transactions, from fast food to digital content, are attracting Debit Check cardholders, and more and more merchants are opening their doors to this burgeoning payment method. The topic for this dissertation is to review the Debit Card marketplace, culminating in addressing the question “What is the scope of new Debit check cards?” The literature review indicates that there are developing opportunities within the marketplace that could offer the Debit Check Car...

  10. SU-D-BRD-04: The Impact of Automatic Radiation Therapy Plan Checks in Treatment Planning

    International Nuclear Information System (INIS)

    Purpose: The physics plan check verifies various aspects of a treatment plan after dosimetrists have finished creating the plan. Some errors in the plan which are caught by the physics check could be caught earlier in the departmental workflow. The purpose of this project was to evaluate a plan checking script that can be run within the treatment planning system (TPS) by the dosimetrists prior to plan approval and export to the record and verify system. Methods: A script was created in the Pinnacle TPS to automatically check 15 aspects of a plan for clinical practice conformity. The script outputs a list of checks which the plan has passed and a list of checks which the plan has failed so that appropriate adjustments can be made. For this study, the script was run on a total of 108 plans: IMRT (46/108), VMAT (35/108) and SBRT (27/108). Results: Of the plans checked by the script, 77/108 (71%) failed at least one of the fifteen checks. IMRT plans resulted in more failed checks (91%) than VMAT (51%) or SBRT (63%), due to the high failure rate of an IMRT-specific check, which checks that no IMRT segment < 5 MU. The dose grid size and couch removal checks caught errors in 10% and 14% of all plans – errors that ultimately may have resulted in harm to the patient. Conclusion: Approximately three-fourths of the plans being examined contain errors that could be caught by dosimetrists running an automated script embedded in the TPS. The results of this study will improve the departmental workflow by cutting down on the number of plans that, due to these types of errors, necessitate re-planning and re-approval of plans, increase dosimetrist and physician workload and, in urgent cases, inconvenience patients by causing treatment delays

  11. SU-D-BRD-03: Improving Plan Quality with Automation of Treatment Plan Checks

    Energy Technology Data Exchange (ETDEWEB)

    Covington, E; Younge, K; Chen, X; Lee, C; Matuszak, M; Kessler, M; Acosta, E; Orow, A; Filpansick, S; Moran, J [University of Michigan Hospital and Health System, Ann Arbor, MI (United States); Keranen, W [Varian Medical Systems, Palo Alto, CA (United States)

    2015-06-15

    Purpose: To evaluate the effectiveness of an automated plan check tool to improve first-time plan quality as well as standardize and document performance of physics plan checks. Methods: The Plan Checker Tool (PCT) uses the Eclipse Scripting API to check and compare data from the treatment planning system (TPS) and treatment management system (TMS). PCT was created to improve first-time plan quality, reduce patient delays, increase efficiency of our electronic workflow, and to standardize and partially automate plan checks in the TPS. A framework was developed which can be configured with different reference values and types of checks. One example is the prescribed dose check where PCT flags the user when the planned dose and the prescribed dose disagree. PCT includes a comprehensive checklist of automated and manual checks that are documented when performed by the user. A PDF report is created and automatically uploaded into the TMS. Prior to and during PCT development, errors caught during plan checks and also patient delays were tracked in order to prioritize which checks should be automated. The most common and significant errors were determined. Results: Nineteen of 33 checklist items were automated with data extracted with the PCT. These include checks for prescription, reference point and machine scheduling errors which are three of the top six causes of patient delays related to physics and dosimetry. Since the clinical roll-out, no delays have been due to errors that are automatically flagged by the PCT. Development continues to automate the remaining checks. Conclusion: With PCT, 57% of the physics plan checklist has been partially or fully automated. Treatment delays have declined since release of the PCT for clinical use. By tracking delays and errors, we have been able to measure the effectiveness of automating checks and are using this information to prioritize future development. This project was supported in part by P01CA059827.

  12. The check sheet for diagnosis of postmortem CT. Development and the first impression

    International Nuclear Information System (INIS)

    We developed the check sheet for diagnosis of postmortem CT. We listed the findings that had been reported as causes of death, postmortem changes, and changes caused by cardiopulmonary resuscitation on the sheet. We used the check sheet for 26 postmortem CT of cases with cardiopulmonary arrest on arrival. The causes of death were proposed in 11 cases. The check sheet was useful to diagnose postmortem CT. (author)

  13. The evolution of the check as a means of payment: A historical survey

    OpenAIRE

    Quinn, Stephen; Roberds, William

    2008-01-01

    Though checks' popularity is now waning in favor of electronic payments, checks were, for much of the twentieth century, the most widely used noncash payment method in the United States. How did such a relatively inefficient form of payment become so dominant? This article traces the historical evolution of the check, focusing on its relation to complementary and competing payment technologies. ; Originating in the eastern Mediterranean during the first millennium as a convenient form of paym...

  14. Scoping study to develop understanding of a natural capital asset check. Revised final report for Defra

    OpenAIRE

    Dickie, Ian; Haines-Young, Roy; Atkinson, Giles; Hails, Rosie

    2012-01-01

    This study has scoped a Natural Capital Asset Check, which was a commitment in the 2010 Natural Environment White Paper. The development of this asset check approach is continuing under the UK National Ecosystem Assessment follow-on project, which will conclude in October 2013. This summary attempts to answer some basic questions about a Natural Capital Asset Check that this scoping study has investigated.

  15. Antibodies to watch in 2016.

    Science.gov (United States)

    Reichert, Janice M

    2016-01-01

    The number of novel antibody therapeutics that received first marketing approvals in 2015 met expectations, with 6 (alirocumab (Praluent®), evolocumab (Repatha®), daratumumab (Darzalex®), dinutuximab (Unituxin®), idarucizumab (Praxbind®), mepolizumab (Nucala®)) granted first approvals as of mid-November*. Seven novel antibody therapeutics (begelomab, brodalumab, elotuzumab, ixekizumab, necitumumab, obiltoxaximab, reslizumab) are in regulatory review, and thus a similar number, if not more, are projected to gain first approvals in 2016. Commercial late-stage antibody therapeutics development exceeded expectations by increasing from 39 candidates in Phase 3 studies as of late 2014 to 53 as of late 2015. Of the 53 candidates, transitions to regulatory review by the end of 2016 are projected for 8 (atezolizumab, benralizumab, bimagrumab, durvalumab, inotuzumab ozogamicin, lebrikizumab, ocrelizumab, tremelimumab). Other "antibodies to watch" include 15 candidates (bavituximab, bococizumab, dupilumab, fasinumab, fulranumab, gevokizumab, guselkumab, ibalizumab, LY2951742, onartuzumab, REGN2222, roledumab, romosozumab, sirukumab, Xilonix) undergoing evaluation in Phase 3 studies that have estimated primary completion dates in 2016. As evidenced by the antibody therapeutics discussed in this perspective, the biopharmaceutical industry has a highly active late-stage clinical pipeline that may deliver numerous new products to the global market in the near future. *See Note added in proof for updates through December 31, 2015. PMID:26651519

  16. The Structure of Wheel Check Valve Influence on Air Block Phenomenon of Piezoelectric Micro-Pump

    OpenAIRE

    Song Chen; Yong Liu; Yanhu Shen; Jiantao Wang; Zhigang Yang

    2015-01-01

    To improve the stability and reliability of the piezoelectric micro-pump, the cause of air block phenomenon is analyzed on the structure of wheel check valve. During the movement of the bubble in the micro-channel, pressure drop occurs, the main factor which influences the bubble going through is opening height of the wheel check valve. Five groups of wheel check valves with different structures are used to test the wheel check valve opening height and air block probability. The experiment re...

  17. Check Point收购诺基亚的安全设备业务

    Institute of Scientific and Technical Information of China (English)

    谢晴

    2009-01-01

    5月11日,Check Point宣布完成收购诺基亚的安全设备业务,这是双方长达12年紧密合作后的合理演进。除了Check Point UTM-1以及Power-1设备外,现在客户还可向Check Point直接购买先前在诺基亚IP硬件平台上运行Check Point安全软件的设备。

  18. Check Point完成诺基亚安全业务收购

    Institute of Scientific and Technical Information of China (English)

    阿呆

    2009-01-01

    Check Point日前宣布,已经完成收购诺基亚的安全设备业务,这是双方长达12年紧密合作后的合理演进。除了Check Point UTM-1以及Power-1设备,现在Check Point还直接销售先前在诺基亚IP硬件平台上运行Check Point安全软件的设备。

  19. Two questions of L. Va${\\rm \\check{\\textbf{s}}}$ on *-clean rings

    OpenAIRE

    Chen, Jianlong; Cui, Jian

    2011-01-01

    A ring $R$ with an involution * is called (strongly) *-clean if every element of $R$ is the sum of a unit and a projection (that commute). All *-clean rings are clean. Va${\\rm \\check{s}}$ [L. Va${\\rm \\check{s}}$, *-Clean rings; some clean and almost clean Baer *-rings and von Neumann algebras, J. Algebra 324 (12) (2010) 3388-3400] asked whether there exists a *-ring that is clean but not *-clean and whether a unit regular and *-regular ring is strongly *-clean. In this paper, we answer both q...

  20. Drug Checking: A prevention measure for a heterogeneous group with high consumption frequency and polydrug use - evaluation of Zurich's drug checking services

    OpenAIRE

    Hungerbühler, I; Buecheli, A; Schaub, Michael P.

    2011-01-01

    BACKGROUND: The increasing party culture in Zurich presents new challenges, especially regarding the consumption of alcohol and so-called party drugs. Streetwork, the youth advisory service of the city of Zurich, has provided onsite and stationary Drug Checking facilities since 2001 and 2006, respectively. Drug Checking always involves filling out an anonymous questionnaire, which allows the collection of important information about a largely unknown group of users and their consumption pa...

  1. Uses of monoclonal antibody 8H9

    Science.gov (United States)

    Cheung, Nai-Kong V.

    2013-04-09

    This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

  2. Autologous antibodies that bind neuroblastoma cells.

    Science.gov (United States)

    Sun, Yujing; Sholler, Giselle S; Shukla, Girja S; Pero, Stephanie C; Carman, Chelsea L; Zhao, Ping; Krag, David N

    2015-11-01

    Antibody therapy of neuroblastoma is promising and our goal is to derive antibodies from patients with neuroblastoma for developing new therapeutic antibodies. The feasibility of using residual bone marrow obtained for clinical indications as a source of tumor cells and a source of antibodies was assessed. From marrow samples, neuroblastoma cells were recovered, grown in cell culture and also implanted into mice to create xenografts. Mononuclear cells from the marrow were used as a source to generate phage display antibody libraries and also hybridomas. Growth of neuroblastoma patient cells was possible both in vitro and as xenografts. Antibodies from the phage libraries and from the monoclonal hybridomas bound autologous neuroblastoma cells with some selectivity. It appears feasible to recover neuroblastoma cells from residual marrow specimens and to generate human antibodies that bind autologous neuroblastoma cells. Expansion of this approach is underway to collect more specimens, optimize methods to generate antibodies, and to evaluate the bioactivity of neuroblastoma-binding antibodies. PMID:26210205

  3. Antisperm antibodies and in vitro fertilization.

    Science.gov (United States)

    Janssen, H J; Bastiaans, B A; Goverde, H J; Hollanders, H M; Wetzels, A A; Schellekens, L A

    1992-08-01

    The purpose of this study was to investigate the influence of antisperm antibodies in the male, the female, or both partners on the outcome of in vitro fertilization treatment. The results in terms of ongoing pregnancies in the male and female antibody-positive group were the same as in the antibody-negative group. In the double antibody-positive group two of the three patients became pregnant. When high levels of antisperm antibodies were present on the spermatozoa, the fertilization rate was significantly reduced. In the female positive group no clear relationship between the antibody titer and the fertilization percentage could be detected. Abnormal semen quality was responsible for a much lower fertilization rate than the presence of antibodies. The conclusion of this study is that in vitro fertilization provides an equal change of conception in couples with antisperm antibodies in comparison with couples with no antibodies if the other semen parameters are normal. PMID:1472812

  4. Remembering antibodies coming of age.

    Science.gov (United States)

    Melchers, Fritz

    2016-01-01

    Fifty years ago, Norbert Hilschmann discovered that antibodies have variable immunoglobulin domains to bind antigens, and constant domains to carry out effector functions in the immune system. Just as this happened, the author of this perspective entered the field of immunology. Ten years later, the genetic basis of antibody variability was discovered by Susumu Tonegawa and his colleagues at the Basel Institute for Immunology, where the author had become a scientific member. At the same time, Georges Köhler, a former graduate student of the author's at the Basel Institute, invented with Cesar Milstein at the Laboratory of Molecular Biology in Cambridge, England, the method to produce monoclonal antibodies. The author describes here his memories connected to these three monumental, paradigm-changing discoveries, which he observed in close proximity. PMID:27144253

  5. Molecular-specific urokinase antibodies

    Science.gov (United States)

    Atassi, M. Zouhair (Inventor); Morrison, Dennis R. (Inventor)

    2009-01-01

    Antibodies have been developed against the different molecular forms of urokinase using synthetic peptides as immunogens. The peptides were synthesized specifically to represent those regions of the urokinase molecules which are exposed in the three-dimensional configuration of the molecule and are uniquely homologous to urokinase. Antibodies are directed against the lysine 158-isoleucine 159 peptide bond which is cleaved during activation from the single-chain (ScuPA) form to the bioactive double chain (54 KDa and 33 KDa) forms of urokinase and against the lysine 135 lysine 136 bond that is cleaved in the process of removing the alpha-chain from the 54 KDa form to produce the 33 KDa form of urokinase. These antibodies enable the direct measurement of the different molecular forms of urokinase from small samples of conditioned medium harvested from cell cultures.

  6. Commissioning and Implementation of an EPID Based IMRT QA System "Dosimetry Check" for 3D Absolute Dose Measurements and Quantitative Comparisons to MapCheck

    Science.gov (United States)

    Patel, Jalpa A.

    The software package "Dosimetry Check" by MathResolutions, LLC, provides an absolute 3D volumetric dose measurement for IMRT QA using the existing Electronic Portal Imaging Device (EPID) mounted on most linear accelerators. This package provides a feedback loop using the patient's treatment planning CT data as the phantom for dose reconstruction. The aim of this work is to study the difference between point, planar and volumetric doses with MapCheck and Dosimetry Check via the use of the EPID and the diode array respectively. Evaluating tools such as point doses at isocenter, 1-D profiles, gamma volume histograms, and dose volume histograms are used for IMRT dose comparison in three types of cases: head and neck, prostate, and lung. Dosimetry Check can be a valuable tool for IMRT QA as it uses patient specific attenuation corrections and the superiority of the EPID as compared to the MapCheck diode array. This helps reduce the uncertainty in dose for less variability in delivery and a more realistic measured vs computed dose verification system as compared to MapCheck.

  7. Cross-checking different sources of mobility information.

    Science.gov (United States)

    Lenormand, Maxime; Picornell, Miguel; Cantú-Ros, Oliva G; Tugores, Antònia; Louail, Thomas; Herranz, Ricardo; Barthelemy, Marc; Frías-Martínez, Enrique; Ramasco, José J

    2014-01-01

    The pervasive use of new mobile devices has allowed a better characterization in space and time of human concentrations and mobility in general. Besides its theoretical interest, describing mobility is of great importance for a number of practical applications ranging from the forecast of disease spreading to the design of new spaces in urban environments. While classical data sources, such as surveys or census, have a limited level of geographical resolution (e.g., districts, municipalities, counties are typically used) or are restricted to generic workdays or weekends, the data coming from mobile devices can be precisely located both in time and space. Most previous works have used a single data source to study human mobility patterns. Here we perform instead a cross-check analysis by comparing results obtained with data collected from three different sources: Twitter, census, and cell phones. The analysis is focused on the urban areas of Barcelona and Madrid, for which data of the three types is available. We assess the correlation between the datasets on different aspects: the spatial distribution of people concentration, the temporal evolution of people density, and the mobility patterns of individuals. Our results show that the three data sources are providing comparable information. Even though the representativeness of Twitter geolocated data is lower than that of mobile phone and census data, the correlations between the population density profiles and mobility patterns detected by the three datasets are close to one in a grid with cells of 2×2 and 1×1 square kilometers. This level of correlation supports the feasibility of interchanging the three data sources at the spatio-temporal scales considered. PMID:25133549

  8. Cross-Checking Different Sources of Mobility Information

    Science.gov (United States)

    Lenormand, Maxime; Picornell, Miguel; Cantú-Ros, Oliva G.; Tugores, Antònia; Louail, Thomas; Herranz, Ricardo; Barthelemy, Marc; Frías-Martínez, Enrique; Ramasco, José J.

    2014-01-01

    The pervasive use of new mobile devices has allowed a better characterization in space and time of human concentrations and mobility in general. Besides its theoretical interest, describing mobility is of great importance for a number of practical applications ranging from the forecast of disease spreading to the design of new spaces in urban environments. While classical data sources, such as surveys or census, have a limited level of geographical resolution (e.g., districts, municipalities, counties are typically used) or are restricted to generic workdays or weekends, the data coming from mobile devices can be precisely located both in time and space. Most previous works have used a single data source to study human mobility patterns. Here we perform instead a cross-check analysis by comparing results obtained with data collected from three different sources: Twitter, census, and cell phones. The analysis is focused on the urban areas of Barcelona and Madrid, for which data of the three types is available. We assess the correlation between the datasets on different aspects: the spatial distribution of people concentration, the temporal evolution of people density, and the mobility patterns of individuals. Our results show that the three data sources are providing comparable information. Even though the representativeness of Twitter geolocated data is lower than that of mobile phone and census data, the correlations between the population density profiles and mobility patterns detected by the three datasets are close to one in a grid with cells of 2×2 and 1×1 square kilometers. This level of correlation supports the feasibility of interchanging the three data sources at the spatio-temporal scales considered. PMID:25133549

  9. Cross-checking different sources of mobility information.

    Directory of Open Access Journals (Sweden)

    Maxime Lenormand

    Full Text Available The pervasive use of new mobile devices has allowed a better characterization in space and time of human concentrations and mobility in general. Besides its theoretical interest, describing mobility is of great importance for a number of practical applications ranging from the forecast of disease spreading to the design of new spaces in urban environments. While classical data sources, such as surveys or census, have a limited level of geographical resolution (e.g., districts, municipalities, counties are typically used or are restricted to generic workdays or weekends, the data coming from mobile devices can be precisely located both in time and space. Most previous works have used a single data source to study human mobility patterns. Here we perform instead a cross-check analysis by comparing results obtained with data collected from three different sources: Twitter, census, and cell phones. The analysis is focused on the urban areas of Barcelona and Madrid, for which data of the three types is available. We assess the correlation between the datasets on different aspects: the spatial distribution of people concentration, the temporal evolution of people density, and the mobility patterns of individuals. Our results show that the three data sources are providing comparable information. Even though the representativeness of Twitter geolocated data is lower than that of mobile phone and census data, the correlations between the population density profiles and mobility patterns detected by the three datasets are close to one in a grid with cells of 2×2 and 1×1 square kilometers. This level of correlation supports the feasibility of interchanging the three data sources at the spatio-temporal scales considered.

  10. Antibody Response to Pneumocystis jirovecii

    OpenAIRE

    Daly, Kieran R.; Huang, Laurence; Morris, Alison; Koch, Judy; Crothers, Kristina; Levin, Linda; Eiser, Shary; Satwah, Supriya; Zucchi, Patrizia; Walzer, Peter D.

    2006-01-01

    We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3–4 weeks (p50 cells/μL and first episode of pneumocystosis were the ...

  11. Radioimmunotherapy with engineered antibody fragments

    International Nuclear Information System (INIS)

    Authors have developed and begun evaluating radiometal-chelated (213Bi) engineered antibody fragments as radioimmunotherapy agents that target the HER2/neu (c-erbB-2) antigen. The diabody format was found to have 40-fold greater affinity for HER2/neu and to be associated with significantly greater tumor localization than is achieved with scFv molecule. It is shown that short-lived isotopes like 213Bi would be most effective when used in conjunction with antibodies that targeted diffuse malignancies (leukemia or lymphoma) or when used for very rapid pretargeted radioimmunotherapy application in which the radioisotope is conjugated to a very small ligand

  12. Antibody sensed protein surface conformation

    Directory of Open Access Journals (Sweden)

    Scott R. Schricker

    2011-12-01

    Full Text Available An antibody-modified atomic force microscope (AFM tip was used to detect conformational changes of fibronectin deposited on a poly(methyl methacrylate/poly(acrylic acid block copolymer compared to PMMA and a random poly(methyl methacrylate/poly(acrylic acid copolymer with an identical chemical composition. Based on the antibody-protein adhesive force maps and phase imaging, it was found that the nanomorphology of the triblock copolymer induces the desired conformation of fibronectin. This finding demonstrates that block copolymer nanomorphology can be used to regulate protein conformation and potentially cellular response.

  13. Antibody profiling sensitivity through increased reporter antibody layering

    Energy Technology Data Exchange (ETDEWEB)

    Apel, William A; Thompson, Vicki S

    2013-02-26

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  14. Antibody profiling sensitivity through increased reporter antibody layering

    Energy Technology Data Exchange (ETDEWEB)

    Apel, William A.; Thompson, Vicki S.

    2013-02-26

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  15. Antibody profiling sensitivity through increased reporter antibody layering

    Energy Technology Data Exchange (ETDEWEB)

    Apel, William A.; Thompson, Vicki S

    2010-04-13

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  16. Antibody profiling sensitivity through increased reporter antibody layering

    International Nuclear Information System (INIS)

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  17. Enhancement of Antibody Titre and Development of Additional Red Cell Alloantibodies Following Intrauterine Transfusion.

    Science.gov (United States)

    Dubey, Anju; Sonker, Atul; Chaudhary, Rajendra

    2016-03-01

    Intrauterine blood transfusion is the mainstay of managing foetuses with severe anemia. It may however result in fetomaternal hemorrhage, which in cases of Rh isoimmunisation may increase the severity of the disease by enhancing the maternal immunological response to fetal antigens. This study was conducted to determine the frequency, specificity and origin of additional red cell antibodies which developed after IUT. The change in the titre of allo anti-D following IUT was also determined. Antibody detection and titration was done on the blood samples of all the patients before and after intrauterine blood transfusion to check for the development of additional antibody and change in the titre of existing anti-D. Severe anemia was found in 17 (58.6 %) fetuses who received a total of 42 ultrasound-guided IUTs. Development of antibodies additional to anti-D in maternal serum was seen in 5 (29.4 %) cases. The specificity of additional alloantibodies was anti-C in four cases whereas it was anti-E in one case. Four fold or greater increase in existing allo-anti D titre was seen in 6 (35.3 %) cases after IUT. Enhancement of maternal sensitisation leading to an increase in maternal antibody titre is particularly seen after the first IUT. Matching of the donor RBCs particularly for Rh antigens might prevent the induction of additional alloantibodies against these antigens. IUT as a treatment modality should be given judiciously and only when the need is inevitable. PMID:26855513

  18. Polyclonal antibody against conserved sequences of mce1A protein blocks MTB infection in macrophages.

    Science.gov (United States)

    Sivagnanam, Sasikala; Namasivayam, Nalini; Chellam, Rajamanickam

    2012-03-01

    The pathogenesis of Mycobacterium tuberculosis is largely due to its ability to enter and survive within human macrophages. It is suggested that a specific protein namely mammalian cell entry protein is involved in the pathogenesis and the specific gene for this protein mce1A has been identified in several pathogenic organisms such as Rickettsia, Shigella, Escherichia coli, Helicobacter, Streptomyces, Klebsiella, Vibrio, Neisseria, Rhodococcus, Nocardioides, Saccharopolyspora erthyrae, and Pseudomonas. Analysis of mce1 operons in the above mentioned organisms through bioinformatics tools has revealed the presence of unique sequences (conserved regions) suggesting that these sequences may be involved in the process of infection. Presently, the mce1A full-length (1,365 bp) region from Mycobacterium bovis and its conserved regions (303 bp) were cloned in to an expression vector and the purified expressed proteins of molecular weight ~47 and ~11 kDa, respectively, were injected to rabbits to raise the polyclonal antibodies. The purified polyclonal antibodies were checked for their ability to inhibit the Mycobacterium infection in cultured human macrophages. In macrophage invasion assay, when antibody added at high concentration, decrease in viable counts was observed in all cell cultures within the first 5 days after infection, where the intracellular bacterial CFU obtained from the infected MTB increased by the 3rd day at low concentration of antibody. The macrophage invasion assay has indicated that the purified antibodies of mce1A conserved region can inhibit the infection of Mycobacterium. PMID:22159737

  19. 27 CFR 70.61 - Payment by check or money order.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Payment by check or money... Collection of Excise and Special (Occupational) Tax Receipt of Payment § 70.61 Payment by check or money... State, Territory, or possession of the United States, or money orders in payment for internal...

  20. 26 CFR 301.6311-1 - Payment by check or money order.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Payment by check or money order. 301.6311-1... by check or money order. (a) Authority to receive—(1) In general. (i) District directors, Service... District of Columbia, or any possession of the United States, or money orders in payment for...

  1. The Structure of Wheel Check Valve Influence on Air Block Phenomenon of Piezoelectric Micro-Pump

    Directory of Open Access Journals (Sweden)

    Song Chen

    2015-11-01

    Full Text Available To improve the stability and reliability of the piezoelectric micro-pump, the cause of air block phenomenon is analyzed on the structure of wheel check valve. During the movement of the bubble in the micro-channel, pressure drop occurs, the main factor which influences the bubble going through is opening height of the wheel check valve. Five groups of wheel check valves with different structures are used to test the wheel check valve opening height and air block probability. The experiment results show that reducing the wheel check valve thickness or diameter ratio can both increase the wheel check valve opening height, and decrease the air block probability. Through experiment, the optimum combination of the wheel check valve structure is obtained within the samples: as the thickness is 0.02 mm, the diameter ratio is 1.2, the wheel check valve opening height gets 252 µm, and within the given bubble volume, the air block probability is less than 2%.

  2. 21 CFR 1301.93 - Sources of information for employee checks.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Sources of information for employee checks. 1301...-Practitioners § 1301.93 Sources of information for employee checks. DEA recommends that inquiries concerning... place of birth, and other identifying information, to local courts and law enforcement agencies...

  3. 32 CFR Appendix A to Part 86 - Criminal History Background Check Procedures

    Science.gov (United States)

    2010-07-01

    ..., security office, criminal investigators, or local law enforcement) local files checks, Drug and Alcohol... using currently established procedures for completing background checks described in 32 CFR part 310... report through the Privacy Program described in 32 CFR part 310. The individual may provide...

  4. Gender Check - veel kord soolisusest Ida-Euroopa kunstis / Mare Tralla

    Index Scriptorium Estoniae

    Tralla, Mare, 1967-

    2010-01-01

    Novembris 2010 Viinis toimunud konverentsist, kus analüüsiti näituse "Gender Check. Feminiinsus ja maskuliinsus Ida-Euroopa kunstis" kogemust ning sellele eelnenud ja järgnenud uurimistöö tulemusi. Esitleti artiklite kogumikku "Gender check: a reader : art and theory in Eastern Europe". "Gender Checki" projekti edasisest saatusest ja mõjust

  5. 14 CFR 91.1095 - Initial and transition training and checking: Flight instructors (aircraft), flight instructors...

    Science.gov (United States)

    2010-01-01

    ... instructors (simulator). (a) No program manager may use a person nor may any person serve as a flight... observation of an FAA inspector, a program manager check pilot, or an aircrew designated examiner employed by the program manager. The observation check may be accomplished in part or in full in an aircraft, in...

  6. 28 CFR 105.23 - Procedure for requesting criminal history record check.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Procedure for requesting criminal history record check. 105.23 Section 105.23 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY BACKGROUND CHECKS Private Security Officer Employment § 105.23 Procedure for requesting...

  7. 14 CFR 91.171 - VOR equipment check for IFR operations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false VOR equipment check for IFR operations. 91... Instrument Flight Rules § 91.171 VOR equipment check for IFR operations. (a) No person may operate a civil aircraft under IFR using the VOR system of radio navigation unless the VOR equipment of that aircraft—...

  8. Yarning about health checks: barriers and enablers in an urban Aboriginal medical service.

    Science.gov (United States)

    Jennings, Warren; Spurling, Geoffrey K; Askew, Deborah A

    2014-01-01

    The annual health check for Aboriginal and Torres Strait Islander People has been welcomed as a means of conducting a comprehensive assessment to address preventive health care delivery, identify new diagnoses and initiate new treatments. Rates of health check uptake across Australia have been poor with less than 12% of the eligible population receiving one during 2009/10. This qualitative study sought to identify barriers and enablers to undertaking health checks in an urban Aboriginal Medical Service through semistructured interviews with 25 clinical staff (doctors, nurses and Aboriginal and Torres Strait Islander health workers). Clinical systems for conducting health checks were unclear to staff, with barriers relating to time pressures for both patients and clinic staff, and lack of clarity about staff responsibilities for initiating and conducting the health check. Additionally some staff perceived some content as sensitive, invasive, culturally inappropriate and of questionable value. Other barriers included concerns about community health literacy, disengagement with preventative health care, and suspicion about confidentiality and privacy. The development of clear service-wide systems that support the conduct of health checks are required to increase uptake, combined with supportive local clinical leadership and audit and feedback systems. Staff training, consideration of culture and roles, and critical review of health check content may improve staff confidence and community acceptance. Community-based health education and promotion is strongly supported by staff to increase client engagement, knowledge and acceptance of the health check. PMID:23552601

  9. 78 FR 14121 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Police Check...

    Science.gov (United States)

    2013-03-04

    ... Collection; Comments Requested: Police Check Inquiry and Pre-Screening Qualifications Certification ACTION...: Revision of an existing collection of information. (2) Title of the Form/Collection: Police Check Inquiry...: Jerri Murray, Department Clearance Officer, Policy and Planning Staff, Justice Management...

  10. Structural Characterization of Peptide Antibodies

    DEFF Research Database (Denmark)

    Chailyan, Anna; Marcatili, Paolo

    2015-01-01

    better understand the underlying mechanisms of antibody-antigen interaction here we present a pipeline developed by us to structurally classify immunoglobulin antigen binding sites and to infer key sequence residues and other variables that have a prominent role in each structural class....

  11. EASY-2005: validation and new tools for data checking

    International Nuclear Information System (INIS)

    The European Activation System (EASY) is the tool developed for activation calculations as part of the Fusion Technology programme. It comprises the EAF nuclear data libraries and the FISPACT inventory code. The version EASY-2005, released last year contains many more neutron-induced reactions than the previous version; an increase of about a factor of five to 62,637. The reason for this was the increase in the upper energy limit from 20 to 60 MeV. A major strand of work within Europe has been the measurement of activation in a series of well-defined neutron spectra, these integral results can then be used to validate a subset of the EAF-2005 library, demonstrating that it can be relied on for activation predictions in similar spectra. A validation report has been produced covering 453 reactions; this shows the integral results and the available differential data from EXFOR for these reactions. For 202 reactions there is good agreement, indicating that the data for the reaction are adequate. In cases of disagreement the report indicates where additional measurements are required or where the library data can be improved. The majority of the data above 20 MeV were obtained from model calculations, and this is also the case for many of the reactions at all energies. Because of the large number of reactions and the lack of experimental data, there was a need to develop new tools that could help in the checking of such a large library. Within the SAFEPAQ-II code that is used for evaluation and production of the EAF libraries, the new methodology of Statistical Analysis of Cross Sections (SACS) has been developed. This enables various quantities such as maximum cross section (σmax), energy at maximum (Emax) and width at half maximum (W0.5) to be plotted as functions of atomic mass (A) and asymmetry parameter (s) for each type of reaction. Such plots show well defined trends and inconsistent data for a particular reaction can easily be identified. Using the integral

  12. Live Transplantation in Children Antibody Production Against ِE. Coli Polypeptide (ECP) by ِDot Blotting and ELISA Methods for ECP Assay in Recombinant Drug and Patients Sera

    OpenAIRE

    A. Rabbani.; MH Sanati; Akrami, H.; G Ahangari

    2003-01-01

    Recombinant DNA technology made it possible to produce biological drugs and pharmaceutical companies produced recombinant human drugs. There have been reports on the formation of antibodies against residual host cell protein. For this reason, it is important to check the patients sera for antibodies which could possibly be induced by recombinant drug it self and/or by contaminating proteins of the host cell. The present report refers to the obtainment of polyspecific antisera directed against...

  13. A study of condition monitoring of check valve using acoustic emission and neural network technique

    International Nuclear Information System (INIS)

    The check valve is one of typical component being extensively used in safety systems of nuclear power plants. The failures of check valves have resulted in significant maintenance efforts, on occasion, have resulted in water hammer, over-pressurization of low-pressure systems, and damage to flow system components. The objective of this research is to demonstrate condition-monitoring system based on acoustic emission, AE detection that can provide timely detection of check valve degradation and service aging so that maintenance/ replacement could be preformed prior to loss of safety function. This work is also focused on the capability of neural network technique to provide diagnostic information useful in determining check valve aging and degradation, check valve failures and undesirable operating modes

  14. The Complexity of Checking Consistency of Pedigree Information and Related Problems

    Institute of Scientific and Technical Information of China (English)

    Luca Aceto; Jens A. Hansen; Anna Ingólfsdóttir; Jacob Johnsen; John Knudsen

    2004-01-01

    Consistency checking is a fundamental computational problem in genetics. Given a pedigree and information on the genotypes (of some) of the individuals in it, the aim of consistency checking is to determine whether these data are consistent with the classic Mendelian laws of inheritance. This problem arose originally from the geneticists' need to filter their input data from erroneous information, and is well motivated from both a biological and a sociological viewpoint. This paper shows that consistency checking is NP-complete, even with focus on a single gene and in the presence of three alleles. Several other results on the computational complexity of problems from genetics that are related to consistency checking are also offered. In particular, it is shown that checking the consistency of pedigrees over two alleles, and of pedigrees without loops, can be done in polynomial time.

  15. Effect of check valve on consequences of coolant pump rotor seizure accident for EPR reactor

    International Nuclear Information System (INIS)

    Counter current flow phenomenon would appear during reactor coolant pump rotor seizure accident. Present work analyzes the coolant pump rotor seizure accident for European Pressurized Reactor (EPR). The accident safety analysis results of model with check valve and with out check valve are compared. It can be found that the check valve can increase the core inlet flow rate of model about 4%. The increasing of coolant flow rate is beneficial to the reactor core cooling. Check valve can increase the minimum departure from nucleate boiling ratio (DNBR), reduce the departure from nucleate boiling (DNB) fraction and the fuel rod cladding temperature about 14℃ during coolant pump rotor seizure accident. The analyses results show that the model with check valve can maintain the integrity of nuclear fuel rod effectively during reactor coolant pump rotor seizure accident. (authors)

  16. PVeStA: A Parallel Statistical Model Checking and Quantitative Analysis Tool

    KAUST Repository

    AlTurki, Musab

    2011-01-01

    Statistical model checking is an attractive formal analysis method for probabilistic systems such as, for example, cyber-physical systems which are often probabilistic in nature. This paper is about drastically increasing the scalability of statistical model checking, and making such scalability of analysis available to tools like Maude, where probabilistic systems can be specified at a high level as probabilistic rewrite theories. It presents PVeStA, an extension and parallelization of the VeStA statistical model checking tool [10]. PVeStA supports statistical model checking of probabilistic real-time systems specified as either: (i) discrete or continuous Markov Chains; or (ii) probabilistic rewrite theories in Maude. Furthermore, the properties that it can model check can be expressed in either: (i) PCTL/CSL, or (ii) the QuaTEx quantitative temporal logic. As our experiments show, the performance gains obtained from parallelization can be very high. © 2011 Springer-Verlag.

  17. Production of antibody labeled gold nanoparticles for influenza virus H5N1 diagnosis kit development

    International Nuclear Information System (INIS)

    Preparation of colloidal gold conjugated antibodies specific for influenza A/H5N1 and its use in developing a virus A/H5N1 rapid diagnostic kit is presented. Colloidal gold nanoparticles (AuNPs) were prepared through citrate reduction. Single chain antibodies specific to H5N1 (scFv7 and scFv24) were produced using pTI2 + vector and E. coli strain HB2151. These antibodies were purified by affinity chromatography technique employing HiTrap Chelating HP columns pre-charged with Ni2 + . The method for preparation of antibody–colloidal gold conjugate was based on electrostatic force binding antibody with colloidal gold. The effect of factors such as pH and concentration of antibody has been quantitatively analyzed using spectroscopic methods after adding 1 wt% NaCl which induced AuNP aggregation. The morphological study by scanning electron microscopy (SEM) showed that the average size of the spherical AuNPs was 23 nm with uniform sizes. The spectroscopic properties of colloidal AuNPs showed the typical surface plasmon resonance band at 523 nm in UV-visible spectrum. The optimal pH of conjugated colloidal gold was found between 8.0 and 10.0. The activity of synthesized antibody labeled AuNPs for detection of H5N1 flu virus was checked by dot blot immunological method. The results confirmed the ability in detection of the A/H5N1 virus of the prepared antibody labeled gold particles and opened up the possibility of using them in manufacturing rapid detection kit for this virus. (paper)

  18. Alternative affinity tools: more attractive than antibodies?

    NARCIS (Netherlands)

    Ruigrok, V.J.B.; Levisson, M.; Eppink, M.H.M.; Smidt, H.; Oost, van der J.

    2011-01-01

    Antibodies are the most successful affinity tools used today, in both fundamental and applied research (diagnostics, purification and therapeutics). Nonetheless, antibodies do have their limitations, including high production costs and low stability. Alternative affinity tools based on nucleic acids

  19. Detection of Campylobacter species using monoclonal antibodies

    Science.gov (United States)

    Young, Colin R.; Lee, Alice; Stanker, Larry H.

    1999-01-01

    A panel of species specific monoclonal antibodies were raised to Campylobacter coli, Campylobacter jejuni and Campylobacter lari. The isotypes, and cross-reactivity profiles of each monoclonal antibody against an extensive panel of micro- organisms, were determined.

  20. Progranulin antibodies in autoimmune diseases.

    Science.gov (United States)

    Thurner, Lorenz; Preuss, Klaus-Dieter; Fadle, Natalie; Regitz, Evi; Klemm, Philipp; Zaks, Marina; Kemele, Maria; Hasenfus, Andrea; Csernok, Elena; Gross, Wolfgang L; Pasquali, Jean-Louis; Martin, Thierry; Bohle, Rainer Maria; Pfreundschuh, Michael

    2013-05-01

    Systemic vasculitides constitute a heterogeneous group of diseases. Autoimmunity mediated by B lymphocytes and their humoral effector mechanisms play a major role in ANCA-associated vasculitis (AAV) as well as in non-ANCA associated primary systemic vasculitides and in the different types of autoimmune connective tissue disorders and rheumatoid arthritis. In order to detect autoantibodies in systemic vasculitides, we screened protein macroarrays of human cDNA expression libraries with sera from patients with ANCA-associated and ANCA-negative primary systemic vasculitides. This approach led to the identification of antibodies against progranulin, a 88 kDA secreted glycoprotein with strong anti-inflammatory activity in the course of disease of giant-cell arteritis/polymyalgia rheumatica (14/65), Takayasu's arteritis (4/13), classical panarteritis nodosa (4/10), Behcet's disease (2/6) and in the course of disease in granulomatosis with polyangiitis (31/75), Churg-Strauss syndrome (7/23) and in microscopic polyangiitis (7/19). In extended screenings the progranulin antibodies were also detected in other autoimmune diseases such as systemic lupus erythematosus (39/91) and rheumatoid arthritis (16/44). Progranulin antibodies were detected only in 1 of 97 healthy controls. Anti-progranulin positive patients with systemic vasculitides, systemic lupus erythematosus or rheumatoid arthritis had significant lower progranulin plasma levels, indicating a neutralizing effect. In light of the anti-inflammatory effects of progranulin, progranulin antibodies might exert pro-inflammatory effects thus contributing to the pathogenesis of the respective autoimmune diseases and might serve as a marker for disease activity. This hypothesis is supported by the fact that a positive progranulin antibody status was associated with active disease in granulomatosis with polyangiitis. PMID:23149338

  1. Family study of pediatric patients with primary antibody deficiencies.

    Directory of Open Access Journals (Sweden)

    Nima Rezaei

    2013-12-01

    Full Text Available Common variable immunodeficiency (CVID and selective IgA deficiency (SIGAD are the most common primary antibody deficiencies. These two diseases may have coincidence in one family and SIGAD can progress to CVID which suggest common underlying genetic defects between SIGAD and CVID. This study was designed to find the prevalence of multiple cases in families of Iranian patients with CVID or SIGAD.Serum samples were collected from all available first-degree relatives of 37 patients (23 patients with CVID and 14 with SIGAD to check the levels of immunoglobulin and their subclasses and detect antibody deficiencies.First degree family members of 37 patients (106 individuals were enrolled in this study. Thirty two percent of patients had multiple cases in their families. The frequency of primary antibody deficiency in the first relatives of the patients was estimated to be one per 9 family members. Most of the patients found among family members were siblings of the primary patients. Analysis in SIGAD family members showed that IgG and IgA levels in families with multiple cases were significantly lower than family members without multiple cases (p values of 0.048 and 0.021, respectively.Rate of families with multiple cases in Iran is more than the previous studies in other countries. This rate was not affected by the consanguinity of parents (p=0.081 or immunoglobulin level of the patients. Because of higher risk for the prevalence of these disorders in those with a positive family history of immunodeficiency, family screening programs in the patients with CVID and SIGAD can be suggested to be prioritized..

  2. Application of risk-based methods to inservice testing of check valves

    Energy Technology Data Exchange (ETDEWEB)

    Closky, N.B.; Balkey, K.R.; McAllister, W.J. [and others

    1996-12-01

    Research efforts have been underway in the American Society of Mechanical Engineers (ASME) and industry to define appropriate methods for the application of risk-based technology in the development of inservice testing (IST) programs for pumps and valves in nuclear steam supply systems. This paper discusses a pilot application of these methods to the inservice testing of check valves in the emergency core cooling system of Georgia Power`s Vogtle nuclear power station. The results of the probabilistic safety assessment (PSA) are used to divide the check valves into risk-significant and less-risk-significant groups. This information is reviewed by a plant expert panel along with the consideration of appropriate deterministic insights to finally categorize the check valves into more safety-significant and less safety-significant component groups. All of the more safety-significant check valves are further evaluated in detail using a failure modes and causes analysis (FMCA) to assist in defining effective IST strategies. A template has been designed to evaluate how effective current and emerging tests for check valves are in detecting failures or in finding significant conditions that are precursors to failure for the likely failure causes. This information is then used to design and evaluate appropriate IST strategies that consider both the test method and frequency. A few of the less safety-significant check valves are also evaluated using this process since differences exist in check valve design, function, and operating conditions. Appropriate test strategies are selected for each check valve that has been evaluated based on safety and cost considerations. Test strategies are inferred from this information for the other check valves based on similar check valve conditions. Sensitivity studies are performed using the PSA model to arrive at an overall IST program that maintains or enhances safety at the lowest achievable cost.

  3. The NHS Health Check in England: an evaluation of the first 4 years

    Science.gov (United States)

    Robson, John; Dostal, Isabel; Sheikh, Aziz; Eldridge, Sandra; Madurasinghe, Vichithranie; Griffiths, Chris; Coupland, Carol; Hippisley-Cox, Julia

    2016-01-01

    Objectives To describe implementation of a new national preventive programme to reduce cardiovascular morbidity. Design Observational study over 4 years (April 2009—March 2013). Setting 655 general practices across England from the QResearch database. Participants Eligible adults aged 40–74 years including attendees at a National Health Service (NHS) Health Check. Intervention NHS Health Check: routine structured cardiovascular check with support for behavioural change and in those at highest risk, treatment of risk factors and newly identified comorbidity. Results Of 1.68 million people eligible for an NHS Health Check, 214 295 attended in the period 2009–12. Attendance quadrupled as the programme progressed; 5.8% in 2010 to 30.1% in 2012. Attendance was relatively higher among older people, of whom 19.6% of those eligible at age 60–74 years attended and 9.0% at age 40–59 years. Attendance by population groups at higher cardiovascular disease (CVD) risk, such as the more socially disadvantaged 14.9%, was higher than that of the more affluent 12.3%. Among attendees 7844 new cases of hypertension (38/1000 Checks), 1934 new cases of type 2 diabetes (9/1000 Checks) and 807 new cases of chronic kidney disease (4/1000 Checks) were identified. Of the 27 624 people found to be at high CVD risk (20% or more 10-year risk) when attending an NHS Health Check, 19.3% (5325) were newly prescribed statins and 8.8% (2438) were newly prescribed antihypertensive therapy. Conclusions NHS Health Check coverage was lower than expected but showed year-on-year improvement. Newly identified comorbidities were an important feature of the NHS Health Checks. Statin treatment at national scale for 1 in 5 attendees at highest CVD risk is likely to have contributed to important reductions in their CVD events. PMID:26762161

  4. Application of risk-based methods to inservice testing of check valves

    International Nuclear Information System (INIS)

    Research efforts have been underway in the American Society of Mechanical Engineers (ASME) and industry to define appropriate methods for the application of risk-based technology in the development of inservice testing (IST) programs for pumps and valves in nuclear steam supply systems. This paper discusses a pilot application of these methods to the inservice testing of check valves in the emergency core cooling system of Georgia Power's Vogtle nuclear power station. The results of the probabilistic safety assessment (PSA) are used to divide the check valves into risk-significant and less-risk-significant groups. This information is reviewed by a plant expert panel along with the consideration of appropriate deterministic insights to finally categorize the check valves into more safety-significant and less safety-significant component groups. All of the more safety-significant check valves are further evaluated in detail using a failure modes and causes analysis (FMCA) to assist in defining effective IST strategies. A template has been designed to evaluate how effective current and emerging tests for check valves are in detecting failures or in finding significant conditions that are precursors to failure for the likely failure causes. This information is then used to design and evaluate appropriate IST strategies that consider both the test method and frequency. A few of the less safety-significant check valves are also evaluated using this process since differences exist in check valve design, function, and operating conditions. Appropriate test strategies are selected for each check valve that has been evaluated based on safety and cost considerations. Test strategies are inferred from this information for the other check valves based on similar check valve conditions. Sensitivity studies are performed using the PSA model to arrive at an overall IST program that maintains or enhances safety at the lowest achievable cost

  5. Virus Strain Discrimination Using Recombinant Antibodies

    OpenAIRE

    Boonham, N.; Barker, I.

    2002-01-01

    Most routine testing for plant viruses is currently carried out using monoclonal and polyclonal antibodies. Traditional methods of antibody production however can be time consuming and require the use of expensive cell culture facilities. Recombinant antibody technology however is starting to make an impact in this area, enabling the selection of antibody fragments in a few weeks compared with the many months associated with traditional methods and requires only basic microbiological faciliti...

  6. Application of commercial enzyme linked immunosorbent assays (ELISA for the detection of antibodies for foot-and-mouth disease virus in wild boar and red deer

    Directory of Open Access Journals (Sweden)

    Terzić Svjetlana

    2012-01-01

    Full Text Available For detecting antibodies towards foot and mouth (FMD virus in sera collected from red deer hinds (Cervus elaphus and wild boars (Sus scrofa, three commercially available enzyme-linked immunosorbent assays (ELISA were used. Two ELISA kits (PrioCHECK FMDV NS and CHEKIT FMD-3ABC were used for the detection of antibodies towards non-structural proteins of FMD virus and one assay was based on the detection of antibodies for serotype O (PrioCHECK FMDV type O. All of the sera tested in our study were negative for antibodies against FMD virus. The aim of this study was to investigate the usefulness of commercially available ELISA kits given for marketing authorization in Croatia in testing the prevalence of FMD antibodies in wild boar and red deer populations. Since the producers of ELISA kits used in our study did not declare wild animals as a target species, we hypothesised that the same kits could be used for serological diagnosis of FMD in red deer and wild boars. Our study confirmed that the kits used are acceptable for detecting antibodies in both species tested, however, the investigation highlighted the problem of validating the kits due to the absence of available positive sera originating from red deer, as well as other susceptible species, especially artiodactyls.

  7. Immunoglobulin G4: an odd antibody

    NARCIS (Netherlands)

    R.C. Aalberse; S.O. Stapel; J. Schuurman; T. Rispens

    2009-01-01

    Despite its well-known association with IgE-mediated allergy, IgG4 antibodies still have several poorly understood characteristics. IgG4 is a very dynamic antibody: the antibody is involved in a continuous process of half-molecules (i.e. a heavy and attached light-chain) exchange. This process, also

  8. Medication double-checking procedures in clinical practice: a cross-sectional survey of oncology nurses' experiences

    Science.gov (United States)

    Pfeiffer, Yvonne; Taxis, Katja

    2016-01-01

    Background Double-checking is widely recommended as an essential method to prevent medication errors. However, prior research has shown that the concept of double-checking is not clearly defined, and that little is known about actual practice in oncology, for example, what kind of checking procedures are applied. Objective To study the practice of different double-checking procedures in chemotherapy administration and to explore nurses' experiences, for example, how often they actually find errors using a certain procedure. General evaluations regarding double-checking, for example, frequency of interruptions during and caused by a check, or what is regarded as its essential feature was assessed. Methods In a cross-sectional survey, qualified nurses working in oncology departments of 3 hospitals were asked to rate 5 different scenarios of double-checking procedures regarding dimensions such as frequency of use in practice and appropriateness to prevent medication errors; they were also asked general questions about double-checking. Results Overall, 274 nurses (70% response rate) participated in the survey. The procedure of jointly double-checking (read-read back) was most commonly used (69% of respondents) and rated as very appropriate to prevent medication errors. Jointly checking medication was seen as the essential characteristic of double-checking—more frequently than ‘carrying out checks independently’ (54% vs 24%). Most nurses (78%) found the frequency of double-checking in their department appropriate. Being interrupted in one's own current activity for supporting a double-check was reported to occur frequently. Regression analysis revealed a strong preference towards checks that are currently implemented at the responders' workplace. Conclusions Double-checking is well regarded by oncology nurses as a procedure to help prevent errors, with jointly checking being used most frequently. Our results show that the notion of independent checking needs to be

  9. Production, isolation, and characterization of rabbit anti-idiotypic antibodies directed against human antithyrotrophin receptor antibodies.

    OpenAIRE

    Baker, J. R.; Lukes, Y G; Burman, K. D.

    1984-01-01

    Previous studies have shown that anti-idiotypic antibodies can be developed in vivo through animal immunization with idiotype, and that these antibodies can be isolated from other anti-immunoglobulin antibodies by affinity purification. These techniques have relied on large amounts of idiotype, which were produced either by hyperimmunization or by monoclonal antibodies, to serve as the affinity adsorbent. In the present study, we produced anti-idiotypic antibodies to human anti-thyroid-stimul...

  10. Patients With Obsessive-Compulsive Disorder Check Excessively in Response to Mild Uncertainty.

    Science.gov (United States)

    Toffolo, Marieke B J; van den Hout, Marcel A; Engelhard, Iris M; Hooge, Ignace T C; Cath, Daniëlle C

    2016-07-01

    Patients with obsessive-compulsive disorder (OCD) not only respond to obsessions with perseverative checking, but also engage in more general checking, irrespective of their obsessive concerns. This study investigated whether general checking is specific to OCD and exacerbated when only mild uncertainty is induced. Thirty-one patients with OCD, 26 anxiety- and 31 healthy controls performed a visual search task with eye-tracking and indicated in 50 search displays whether a target was "present" or "absent". Target-present trials were unambiguous, whereas target-absent trials induced mild uncertainty, because participants had to rely on not overlooking the target. Checking behavior was measured by assessing search time and the number of fixations, measured with an eye-tracker. Results showed that in both target-present and target-absent trials patients with OCD searched longer and made more fixations than healthy and anxiety controls. However, the difference in checking behavior between patients with OCD and the control groups was larger in target-absent trials (where mild uncertainty was induced). Anxiety and healthy controls did not differ in checking behavior. Thus, mild uncertainty appears to specifically promote checking in patients with OCD, which has implications for treatment. PMID:27423170

  11. Evidence for the safety assurance of the radiation associated equipments for stat-up check

    International Nuclear Information System (INIS)

    Based on the new amendment of the Medical Service Law and the Pharmaceutical Affairs Law, the safety control for the medical equipments and devices was strengthened; and a radiological technologist should be stipulated as a safety control manager for the medical equipments and devices. Although it is thought that Start-up check is important for the safety assurance, the enforcement situation is not clear until now. In this report, on the occasion of the start-up of the new Law, questionnaire about the start up check (time and a check items) were investigated from 56 hospitals applying the visit interview. Modality by modality check up time was obtained from 261 institutions by the descriptive study paper type. Start-up check and arming up were applied for almost all modalities about 30 minutes before start of the clinical tests. The check up items for the medical equipments and devices depended on each hospital. Therefore, safety assurance should be established, cooperating with the medical equipment distributors, the hospital sharing the checked results for the patients' safety. (author)

  12. Transient analysis for a system with a tilted disc check valve

    International Nuclear Information System (INIS)

    Check valves are used to prevent reverse flow conditions in a variety of systems in nuclear power plants. When a check valve is closed by a reverse flow, the transient load can jeopardize the structural integrity on the piping system and its supports. It may also damage intended function of the in-line components even though the severity of the load differs and depends strongly on types of the check valves. To incorporate the transient load in the piping system, it is very important to properly predict the system response to transients such as a check valve closure accompanied by pump trip and to evaluate the system transient. The one-dimensional transient simulation codes such as the RELAP5/MOD3.3 and TRACE were used. There has not been a single model that integrates the two codes to handle the behavior of a tilted disc check valve, which is designed to mitigate check valve slams by shorting the travel of the disc. In this paper a model is presented to predict the dynamic motion of a tilted disc check valve in the transient simulation using the RELAP5/MOD3.3 code and the model is incorporated in a system transient analysis using control variables of the code. In addition, transient analysis for Essential Service Water (ESW) system is performed using the proposed model and the associated load is evaluated for the system. (author)

  13. Development of a butterfly check valve model under natural circulation conditions

    International Nuclear Information System (INIS)

    Highlights: • Bases on Lim’s swing check valve model, a butterfly check valve model was developed. • The method to quantify the friction torque TF in Li’s model was corrected. • The developed model was implemented into the RELAP5 code and verified. - Abstract: A butterfly check valve is widely used to prevent a reverse flow in the pipe lines of a marine nuclear power plant. Under some conditions, the natural circulation conditions in particular, the fluid velocity through the butterfly check valve might become too low to hold the valve disk fully open, thereby the flow resistance of the butterfly check valve varies with the location of the valve disk and as a result the fluid flow is significantly affected by the dynamic motion of the valve disk. Simulation of a pipe line that includes some butterfly check valves, especially under natural circulation conditions, is thus complicated. This paper focuses on the development of a butterfly check valve model to enhance the capability of the thermal–hydraulic system code and the developed model is implemented into the RELAP5 code. Both steady-state calculations and transient calculations were carried out for the primary loop system of a marine nuclear power plant and the calculation results are compared with the experimental data for verification purpose. The simulation results show an agreement with the experimental data

  14. Solid phase double-antibody radioimmunoassay procedure

    International Nuclear Information System (INIS)

    The present invention is concerned with the radioimmunoassay (RIA) procedure for assaying body fluid content of an antigenic substance which may either be an antigen itself or a hapten capable of being converted, such as by means of reaction with a protein, to an antigenic material. The present invention is concerned with a novel and improved modification of a double-antibody RIA technique in which there is a first antibody that is specific to the antigenic substance suspected to be present in a body fluid from which the assay is intended. The second antibody, however, is not specific to the antigenic substance or analyte, but is an antibody against the first antibody

  15. The role of antibodies in myasthenia gravis.

    Science.gov (United States)

    De Baets, M; Stassen, M H W

    2002-10-15

    Myasthenia gravis is an autoimmune disease associated with antibodies directed to the postsynaptic acetylcholine receptor. These antibodies reduce the number of receptors. Autoantibodies against AChR and other muscle antigens can be used for the diagnosis of myasthenia gravis and related disorders. The origin and the role of these antibodies in the disease are discussed. Experimental autoimmune myasthenia gravis, an experimental model closely mimicking the disease, has provided answers to many questions about the role of antibodies, complement macrophages and AChR anchor proteins. Genetically modified anti-AChR antibodies may also be used in the future to treat myasthenia. PMID:12220686

  16. Production of Monoclonal Antibody against Human Nestin.

    Science.gov (United States)

    Hadavi, Reza; Zarnani, Amir Hassan; Ahmadvand, Negah; Mahmoudi, Ahmad Reza; Bayat, Ali Ahmad; Mahmoudian, Jafar; Sadeghi, Mohammad-Reza; Soltanghoraee, Haleh; Akhondi, Mohammad Mehdi; Tarahomi, Majid; Jeddi-Tehrani, Mahmood; Rabbani, Hodjattallah

    2010-04-01

    We have employed a peptide-based antibody generation protocol for producing antibody against human nestin. Using a 12-mer synthetic peptide from repetitive region of human nestin protein devoid of any N- or O-glyco-sylation sequences, we generated a mouse monoclonal antibody capable of recognizing human, mouse, bovine, and rat nestin. A wide variety of nestin proteins ranging from 140-250 kDa was detected by this antibody. This antibody is highly specific and functional in applications such as ELISA, flow cytometry, immunocytochemistry, and Western blot assays. PMID:23407796

  17. Production of Monoclonal Antibody against Human Nestin

    OpenAIRE

    Hadavi, Reza; Zarnani, Amir Hassan; Ahmadvand, Negah; Mahmoudi, Ahmad Reza; Bayat, Ali Ahmad; Mahmoudian, Jafar; Sadeghi, Mohammad-Reza; Soltanghoraee, Haleh; Akhondi, Mohammad mehdi; Tarahomi, Majid; Jeddi-Tehrani, Mahmood; Rabbani, Hodjattallah

    2010-01-01

    We have employed a peptide-based antibody generation protocol for producing antibody against human nestin. Using a 12-mer synthetic peptide from repetitive region of human nestin protein devoid of any N- or O-glyco-sylation sequences, we generated a mouse monoclonal antibody capable of recognizing human, mouse, bovine, and rat nestin. A wide variety of nestin proteins ranging from 140–250 kDa was detected by this antibody. This antibody is highly specific and functional in applications such a...

  18. SU-D-BRD-01: An Automated Physics Weekly Chart Checking System Supporting ARIA

    Energy Technology Data Exchange (ETDEWEB)

    Chang, X; Yang, D [Washington University in St Louis, St Louis, MO (United States)

    2015-06-15

    Purpose: A software tool was developed in this study to perform automatic weekly physics chart check on the patient data in ARIA. The tool accesses the electronic patient data directly from ARIA server and checks the accuracy of treatment deliveries, and generates reports which summarize the delivery history and highlight the errors. Methods: The tool has four modules. 1) The database interface is designed to directly access treatment delivery data from the ARIA database before reorganizing the data into the patient chart tree (PCT). 2) PCT is a core data structure designed to store and organize the data in logical hierarchies, and to be passed among functions. 3) The treatment data check module analyzes the organized data in PCT and stores the checking results into PCT. 4) Report generation module generates reports containing the treatment delivery summary, chart checking results and plots of daily treatment setup parameters (couch table positions, shifts of image guidance). The errors that are found by the tool are highlighted with colors. Results: The weekly check tool has been implemented in MATLAB and clinically tested at two major cancer centers. Javascript, cascading style sheets (CSS) and dynamic HTML were employed to create the user-interactive reports. It takes 0.06 second to search the delivery records of one beam with PCT and compare the delivery records with beam plan. The reports, saved in the HTML files on shared network folder, can be accessed by web browser on computers and mobile devices. Conclusion: The presented weekly check tool is useful to check the electronic patient treatment data in Varian ARIA system. It could be more efficient and reliable than the manually check by physicists. The work was partially supported by a research grant from Varian Medical System.

  19. SU-D-BRD-01: An Automated Physics Weekly Chart Checking System Supporting ARIA

    International Nuclear Information System (INIS)

    Purpose: A software tool was developed in this study to perform automatic weekly physics chart check on the patient data in ARIA. The tool accesses the electronic patient data directly from ARIA server and checks the accuracy of treatment deliveries, and generates reports which summarize the delivery history and highlight the errors. Methods: The tool has four modules. 1) The database interface is designed to directly access treatment delivery data from the ARIA database before reorganizing the data into the patient chart tree (PCT). 2) PCT is a core data structure designed to store and organize the data in logical hierarchies, and to be passed among functions. 3) The treatment data check module analyzes the organized data in PCT and stores the checking results into PCT. 4) Report generation module generates reports containing the treatment delivery summary, chart checking results and plots of daily treatment setup parameters (couch table positions, shifts of image guidance). The errors that are found by the tool are highlighted with colors. Results: The weekly check tool has been implemented in MATLAB and clinically tested at two major cancer centers. Javascript, cascading style sheets (CSS) and dynamic HTML were employed to create the user-interactive reports. It takes 0.06 second to search the delivery records of one beam with PCT and compare the delivery records with beam plan. The reports, saved in the HTML files on shared network folder, can be accessed by web browser on computers and mobile devices. Conclusion: The presented weekly check tool is useful to check the electronic patient treatment data in Varian ARIA system. It could be more efficient and reliable than the manually check by physicists. The work was partially supported by a research grant from Varian Medical System

  20. Check Point Puts Out Completely New Solution VPN-I VE%Check Point推出全新解决方案VPN-1 VE

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ 日前,Check Point软件技术有限公司推出了VPN-1虚拟版本(VE),它能为虚拟应用程序提供财富500强用于企业网络和数据中心一样水平的安全保护.Check Point是首个可同时为物理网络和虚拟应用程序提供统一网络管理的厂商.