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Sample records for bk060056 antibody check

  1. Model Checking

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 7. Model Checking - Automated Verification of Computational Systems. Madhavan Mukund. General Article Volume 14 Issue 7 July 2009 pp 667-681. Fulltext. Click here to view fulltext PDF. Permanent link:

  2. Regular health checks

    DEFF Research Database (Denmark)

    Grønhøj Larsen, Christian; Jørgensen, Karsten Juhl; Gøtzsche, Peter C

    2012-01-01

    To investigate whether Danish providers of general health checks present a balanced account of possible benefits and harms on their websites and whether the health checks are evidence-based.......To investigate whether Danish providers of general health checks present a balanced account of possible benefits and harms on their websites and whether the health checks are evidence-based....

  3. Annual Check-up

    Science.gov (United States)

    ... Medical Conditions Nutrition & Fitness Emotional Health Annual Check-Up Posted under Health Guides . Updated 24 April 2017. + ... I get ready for my annual medical check-up? If this is your first visit to your ...

  4. Checking Java Programs

    CERN Document Server

    Darwin, Ian

    2007-01-01

    This Short Cut tells you about tools that will improve the quality of your Java code, using checking above and beyond what the standard tools do, including: Using javac options, JUnit and assertions Making your IDE work harder Checking your source code with PMD Checking your compiled code (.class files) with FindBugs Checking your program's run-time behavior with Java PathFinder

  5. checkCIF/PLATON (full publication check)

    Indian Academy of Sciences (India)

    O1W Check. Alert level C. ABSTY02_ALERT_1_C An _exptl_absorpt_correction_type has been given without a literature citation. This should be contained in the ... CELLZ01_ALERT_1_G WARNING: H atoms missing from atom site list. ... 7 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 8 ALERT ...

  6. Environmental Reality Check.

    Science.gov (United States)

    Manicone, Santo

    2001-01-01

    Discusses the importance of educational facilities conducting "reality check" self-audits to uncover the real truth behind underlying environmental problems. An environmental compliance multimedia checklist is included. (GR)

  7. Goat production check list

    DEFF Research Database (Denmark)

    Henriksen, Jørgen; Nielsen, Mette Benedicte Olaf; Madsen, Jørgen

    2009-01-01

    This check list, financed by DanChurchAid, highlights all issues should be carefully investigated before investing in distribution of goats and in interventions to assist poor rural communities to improve their livelihood through goat production....

  8. CMM Interim Check (U)

    Energy Technology Data Exchange (ETDEWEB)

    Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-23

    Coordinate Measuring Machines (CMM) are widely used in industry, throughout the Nuclear Weapons Complex and at Los Alamos National Laboratory (LANL) to verify part conformance to design definition. Calibration cycles for CMMs at LANL are predominantly one year in length. Unfortunately, several nonconformance reports have been generated to document the discovery of a certified machine found out of tolerance during a calibration closeout. In an effort to reduce risk to product quality two solutions were proposed – shorten the calibration cycle which could be costly, or perform an interim check to monitor the machine’s performance between cycles. The CMM interim check discussed makes use of Renishaw’s Machine Checking Gauge. This off-the-shelf product simulates a large sphere within a CMM’s measurement volume and allows for error estimation. Data was gathered, analyzed, and simulated from seven machines in seventeen different configurations to create statistical process control run charts for on-the-floor monitoring.

  9. Checking BEBC superconducting magnet

    CERN Multimedia

    CERN PhotoLab

    1974-01-01

    The superconducting coils of the magnet for the 3.7 m Big European Bubble Chamber (BEBC) had to be checked, see Annual Report 1974, p. 60. The photo shows a dismantled pancake. By December 1974 the magnet reached again the field design value of 3.5 T.

  10. Isomorphism Checking in GROOVE

    NARCIS (Netherlands)

    Rensink, Arend; Zündorf, A.; Varró, D.

    In this paper we show how isomorphism checking can be used as an effective technique for symmetry reduction in graph-based state spaces, despite the inherent complexity of the isomorphism problem. In particular, we show how one can use element-based graph certificate mappings to help in recognising

  11. Check Sample Abstracts.

    Science.gov (United States)

    Alter, David; Grenache, David G; Bosler, David S; Karcher, Raymond E; Nichols, James; Rajadhyaksha, Aparna; Camelo-Piragua, Sandra; Rauch, Carol; Huddleston, Brent J; Frank, Elizabeth L; Sluss, Patrick M; Lewandrowski, Kent; Eichhorn, John H; Hall, Janet E; Rahman, Saud S; McPherson, Richard A; Kiechle, Frederick L; Hammett-Stabler, Catherine; Pierce, Kristin A; Kloehn, Erica A; Thomas, Patricia A; Walts, Ann E; Madan, Rashna; Schlesinger, Kathie; Nawgiri, Ranjana; Bhutani, Manoop; Kanber, Yonca; Abati, Andrea; Atkins, Kristen A; Farrar, Robert; Gopez, Evelyn Valencerina; Jhala, Darshana; Griffin, Sonya; Jhala, Khushboo; Jhala, Nirag; Bentz, Joel S; Emerson, Lyska; Chadwick, Barbara E; Barroeta, Julieta E; Baloch, Zubair W; Collins, Brian T; Middleton, Owen L; Davis, Gregory G; Haden-Pinneri, Kathryn; Chu, Albert Y; Keylock, Joren B; Ramoso, Robert; Thoene, Cynthia A; Stewart, Donna; Pierce, Arand; Barry, Michelle; Aljinovic, Nika; Gardner, David L; Barry, Michelle; Shields, Lisa B E; Arnold, Jack; Stewart, Donna; Martin, Erica L; Rakow, Rex J; Paddock, Christopher; Zaki, Sherif R; Prahlow, Joseph A; Stewart, Donna; Shields, Lisa B E; Rolf, Cristin M; Falzon, Andrew L; Hudacki, Rachel; Mazzella, Fermina M; Bethel, Melissa; Zarrin-Khameh, Neda; Gresik, M Vicky; Gill, Ryan; Karlon, William; Etzell, Joan; Deftos, Michael; Karlon, William J; Etzell, Joan E; Wang, Endi; Lu, Chuanyi M; Manion, Elizabeth; Rosenthal, Nancy; Wang, Endi; Lu, Chuanyi M; Tang, Patrick; Petric, Martin; Schade, Andrew E; Hall, Geraldine S; Oethinger, Margret; Hall, Geraldine; Picton, Avis R; Hoang, Linda; Imperial, Miguel Ranoa; Kibsey, Pamela; Waites, Ken; Duffy, Lynn; Hall, Geraldine S; Salangsang, Jo-Anne M; Bravo, Lulette Tricia C; Oethinger, Margaret D; Veras, Emanuela; Silva, Elvia; Vicens, Jimena; Silva, Elvio; Keylock, Joren; Hempel, James; Rushing, Elizabeth; Posligua, Lorena E; Deavers, Michael T; Nash, Jason W; Basturk, Olca; Perle, Mary Ann; Greco, Alba; Lee, Peng; Maru, Dipen; Weydert, Jamie Allen; Stevens, Todd M; Brownlee, Noel A; Kemper, April E; Williams, H James; Oliverio, Brock J; Al-Agha, Osama M; Eskue, Kyle L; Newlands, Shawn D; Eltorky, Mahmoud A; Puri, Puja K; Royer, Michael C; Rush, Walter L; Tavora, Fabio; Galvin, Jeffrey R; Franks, Teri J; Carter, James Elliot; Kahn, Andrea Graciela; Lozada Muñoz, Luis R; Houghton, Dan; Land, Kevin J; Nester, Theresa; Gildea, Jacob; Lefkowitz, Jerry; Lacount, Rachel A; Thompson, Hannis W; Refaai, Majed A; Quillen, Karen; Lopez, Ana Ortega; Goldfinger, Dennis; Muram, Talia; Thompson, Hannis

    2009-02-01

    The following abstracts are compiled from Check Sample exercises published in 2008. These peer-reviewed case studies assist laboratory professionals with continuing medical education and are developed in the areas of clinical chemistry, cytopathology, forensic pathology, hematology, microbiology, surgical pathology, and transfusion medicine. Abstracts for all exercises published in the program will appear annually in AJCP.

  12. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...... to timed automata. The consistency of the model is verified at different development stages, and the correct linkage between the predicates and their semantic model is checked. The approach is illustrated on a use case from home automation....

  13. The economics of check float

    OpenAIRE

    James J. McAndrews; William Roberds

    2000-01-01

    Checks continue to dominate the market for noncash retail payments in the United States. Each year, U.S. residents write between 65 billion and 70 billion checks, an average of one check per business day per resident. This dependence on checks is unique among developed countries. It is also extremely costly: by switching from checks to other forms of payment, U.S. residents would save between $60 billion and $100 billion dollars per year. ; Why do checks continue to see such wide use within t...

  14. 31 CFR 240.3 - Electronic checks and substitute checks.

    Science.gov (United States)

    2010-07-01

    ... using an electronic check, but this part does not create any right for the presenting bank to return the.... Any financial institution that creates a substitute check or electronic check shall prevent... destroyed, in a manner consistent with federal banking agency guidelines for safeguarding customer...

  15. Check, check, double check: checking the autopilot causes distrust : Experimental studies on the effects of compulsive perseveration

    NARCIS (Netherlands)

    Dek, E.C.P.

    2015-01-01

    Obsessive-compulsive disorder (OCD) is characterized by persistent doubt. The majority of patients with OCD engage in repeated checking to reduce these feelings of uncertainty. However, numerous studies demonstrated that repetitive behavior ironically increases uncertainty: perseverative checking

  16. Cross-Checking the Media

    OpenAIRE

    Rudiger, Jesper

    2013-01-01

    A characteristic of the news market is that consumers often cross-check information, i.e. observe several news outlets. At the same time, data on political media suggest that more partisan consumers are more likely to cross-check. We explore these phenomena by building a model of horizontal competition in newspaper endorsements. Without cross-checking, outlets are unbiased and minimally differentiated. When cross-checking is allowed, we show that cross-checkers are indeed more partisan than ...

  17. Parallel Algorithms for Model Checking

    NARCIS (Netherlands)

    van de Pol, Jaco; Mousavi, Mohammad Reza; Sgall, Jiri

    2017-01-01

    Model checking is an automated verification procedure, which checks that a model of a system satisfies certain properties. These properties are typically expressed in some temporal logic, like LTL and CTL. Algorithms for LTL model checking (linear time logic) are based on automata theory and graph

  18. Ball check valve

    International Nuclear Information System (INIS)

    Bevilacqua, F.

    1978-01-01

    A pressurized nuclear reactor having an instrument assembly sheathed in a metallic tube which is extended vertically upward into the reactor core by traversing a metallic guide tube which is welded to the wall of the vessel is described. Sensors in each instrument assembly are connected to instruments outside the vessel to manifest the conditions within the core. Each instrument assembly probe is moved into position within a metallic guide channel. The guide channel penetrates the wall of the vessel and forms part of the barrier to the environment within the pressure vessel. Each channel includes a ball check valve which is opened by the instrument assembly probe when the probe passes through the valve. A ball valve element is moved from its seat by the probe to a position lateral of the bore of the channel and is guided to its seat along a sloped path within the valve body when the probe is removed. 5 claims, 3 figures

  19. Compositional and Quantitative Model Checking

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand

    2010-01-01

    This paper gives a survey of a composition model checking methodology and its succesfull instantiation to the model checking of networks of finite-state, timed, hybrid and probabilistic systems with respect; to suitable quantitative versions of the modal mu-calculus [Koz82]. The method is based...

  20. Scram system with continuos check

    International Nuclear Information System (INIS)

    Rodriguez Sacco, Walter.

    1976-02-01

    The equipment described pretends to be a further step to the use of integrated circuits in nuclear instrumentation, considering that this type of control was traditionally carried out on the bases of electromechanical elements. A continuous self-check method has been applied in accordance with the high reliability requiered for this type of equipments. The developed equipment fulfils the condition that any deficiency in its component elements, causes an anormal self-detected operation. The equipment covers two systems: the Scram one, that includes the sequence generator-detector, the rods check and scram chain, and the Check system that uses pulses from the sequence detector. (author) [es

  1. Treasury Check Verification Query (TCVQ)

    Data.gov (United States)

    Social Security Administration — The TCVQ system determines the SSN of an individual whose check has been returned to a local field office. The FO is able to request this information via the TCVQ...

  2. Body checking behaviors in men.

    Science.gov (United States)

    Walker, D Catherine; Anderson, Drew A; Hildebrandt, Thomas

    2009-06-01

    Males have been facing increasing pressure from the media to attain a lean, muscular physique, and are at risk for body dissatisfaction, disturbed eating and exercise behaviors, and abuse of appearance- and performance-enhancing drugs (APEDs). The aim of the current study was to examine the relationship between body checking and mood, symptoms of muscle dysmorphia, importance of shape and weight, and APED use in undergraduate males. Body checking in males was correlated with weight and shape concern, symptoms of muscle dysmorphia, depression, negative affect, and APED use. Body checking predicted APED use and uniquely accounted for the largest amount of variance in Muscle Dysmorphic Disorder Inventory (MDDI) scores (16%). Findings support the view that body checking is an important construct in male body image, muscle dysmorphia, and body change strategies and suggest a need for further research.

  3. Model Checking Algorithms for CTMDPs

    DEFF Research Database (Denmark)

    Buchholz, Peter; Hahn, Ernst Moritz; Hermanns, Holger

    2011-01-01

    Continuous Stochastic Logic (CSL) can be interpreted over continuoustime Markov decision processes (CTMDPs) to specify quantitative properties of stochastic systems that allow some external control. Model checking CSL formulae over CTMDPs requires then the computation of optimal control strategie...

  4. Body checking behaviors in men

    OpenAIRE

    Walker, D. Catherine; Anderson, Drew A.; Hildebrandt, Thomas

    2009-01-01

    Males have been facing increasing pressure from the media to attain a lean, muscular physique, and are at risk for body dissatisfaction, disturbed eating and exercise behaviors, and abuse of appearance- and performance-enhancing drugs (APEDs). The aim of the current study was to examine the relationship between body checking and mood, symptoms of muscle dysmorphia, importance of shape and weight, and APED use in undergraduate males. Body checking in males was correlated with weight and shape ...

  5. Transaction management with integrity checking

    DEFF Research Database (Denmark)

    Martinenghi, Davide; Christiansen, Henning

    2005-01-01

    Database integrity constraints, understood as logical conditions that must hold for any database state, are not fully supported by current database technology. It is typically up to the database designer and application programmer to enforce integrity via triggers or tests at the application level......, which are difficult to maintain and error prone. Two important aspects must be taken care of. 1.~It is too time consuming to check integrity constraints from scratch after each update, so simplified checks before each update should be used relying on the assumption that the current state is consistent...

  6. The Probabilistic Model Checking Landscape

    NARCIS (Netherlands)

    Katoen, Joost P.

    Randomization is a key element in sequential and distributed computing. Reasoning about randomized algorithms is highly nontrivial. In the 1980s, this initiated first proof methods, logics, and model-checking algorithms. The field of probabilistic verification has developed considerably since then.

  7. Model checking embedded system designs

    NARCIS (Netherlands)

    Brinksma, Hendrik; Mader, Angelika H.

    2002-01-01

    Model checking has established itself as a successful tool supported technique for the verification and debugging of various hardware and software systems [16]. Not only in academia, but also by industry this technique is increasingly being regarded as a promising and practical proposition,

  8. Advances in Probabilistic Model Checking

    NARCIS (Netherlands)

    Katoen, Joost P.; Barthe, G.; Hermenegildo, M.

    Random phenomena occur in many applications: security, communication protocols, distributed algorithms, and performance and dependability analysis, to mention a few. In the last two decades, efficient model-checking algorithms and tools have been developed to support the automated verification of

  9. Checking Framework Interactions with Relationships

    Science.gov (United States)

    2008-12-01

    Checking Framework Interactions with Relationships Ciera Jaspan Jonathan Aldrich December 2008 CMU-ISR-08-140 Institute for Software Research School...because they are non-local and may break behavioral subtyping. This work presents relationships as a means for specifying framework constraints, and it... Relationships 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7

  10. Antiprothrombin Antibodies

    Directory of Open Access Journals (Sweden)

    Polona Žigon

    2015-05-01

    Full Text Available In patients with the antiphospholipid syndrome (APS, the presence of a group of pathogenic autoantibodies called antiphospholipid antibodies causes thrombosis and pregnancy complications. The most frequent antigenic target of antiphospholipid antibodies are phospholipid bound β2-glycoprotein 1 (β2GPI and prothrombin. The international classification criteria for APS connect the occurrence of thrombosis and/or obstetric complications together with the persistence of lupus anticoagulant, anti-cardiolipin antibodies (aCL and antibodies against β2GPI (anti-β2GPI into APS. Current trends for the diagnostic evaluation of APS patients propose determination of multiple antiphospholipid antibodies, among them also anti-prothrombin antibodies, to gain a common score which estimates the risk for thrombosis in APS patients. Antiprothrombin antibodies are common in APS patients and are sometimes the only antiphospholipid antibodies being elevated. Methods for their determination differ and have not yet been standardized. Many novel studies confirmed method using phosphatidylserine/prothrombin (aPS/PT ELISA as an antigen on solid phase encompass higher diagnostic accuracy compared to method using prothrombin alone (aPT ELISA. Our research group developed an in-house aPS/PT ELISA with increased analytical sensitivity which enables the determination of all clinically relevant antiprothrombin antibodies. aPS/PT exhibited the highest percentage of lupus anticoagulant activity compared to aCL and anti-β2GPI. aPS/PT antibodies measured with the in-house method associated with venous thrombosis and presented the strongest independent risk factor for the presence of obstetric complications among all tested antiphospholipid antibodies

  11. Compositional and Quantitative Model Checking

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand

    2010-01-01

    on the existence of a quotient construction, allowing a property phi of a parallel system phi/A to be transformed into a sufficient and necessary quotient-property yolA to be satisfied by the component 13. Given a model checking problem involving a network Pi I and a property yo, the method gradually move (by...... quotienting) components Pi from the network into the formula co. Crucial to the success of the method is the ability to manage the size of the intermediate quotient-properties by a suitable collection of efficient minimization heuristics....

  12. Model Checking Structured Infinite Markov Chains

    NARCIS (Netherlands)

    Remke, Anne Katharina Ingrid

    2008-01-01

    In the past probabilistic model checking hast mostly been restricted to finite state models. This thesis explores the possibilities of model checking with continuous stochastic logic (CSL) on infinite-state Markov chains. We present an in-depth treatment of model checking algorithms for two special

  13. Program Analysis as Model Checking

    DEFF Research Database (Denmark)

    Olesen, Mads Chr.

    and abstract interpretation. Model checking views the program as a finite automaton and tries to prove logical properties over the automaton model, or present a counter-example if not possible — with a focus on precision. Abstract interpretation translates the program semantics into abstract semantics...... are considered, among others numerical analysis of c programs, and worst-case execution time analysis of ARM programs. It is shown how lattice automata allow automatic and manual tuning of the precision and efficiency of the verification procedure. In the case of worst-case execution time analysis a sound......Software programs are proliferating throughout modern life, to a point where even the simplest appliances such as lightbulbs contain software, in addition to the software embedded in cars and airplanes. The correct functioning of these programs is therefore of the utmost importance, for the quality...

  14. Model Checking as Static Analysis

    DEFF Research Database (Denmark)

    Zhang, Fuyuan

    fairness problems can be encoded into ALFP as well. To deal with multi-valued model checking problems, we have proposed multivalued ALFP. A Moore Family result for multi-valued ALFP is also established, which ensures the existence and uniqueness of the least model. When the truth values in multi-valued...... of states satisfying a CTL formula can be characterized as the least model of ALFP clauses specifying this CTL formula. The existence of the least model of ALFP clauses is ensured by the Moore Family property of ALFP. Then, we take fairness assumptions in CTL into consideration and have shown that CTL...... ALFP constitute a nite distributive complete lattice, multi-valued ALFP can be reduced to two-valued ALFP. This result enables to implement a solver for multi-valued ALFP by reusing existing solvers for twovalued ALFP. Our ALFP-based technique developed for the two-valued CTL naturally generalizes...

  15. QuickChecking Static Analysis Properties

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Møller, Anders

    2015-01-01

    A static analysis can check programs for potential errors. A natural question that arises is therefore: who checks the checker? Researchers have given this question varying attention, ranging from basic testing techniques, informal monotonicity arguments, thorough pen-and-paper soundness proofs......, to verified fixed point checking. In this paper we demonstrate how quickchecking can be useful for testing a range of static analysis properties with limited effort. We show how to check a range of algebraic lattice properties, to help ensure that an implementation follows the formal specification...

  16. QuickChecking static analysis properties

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Møller, Anders

    2017-01-01

    A static analysis can check programs for potential errors. A natural question that arises is therefore: who checks the checker? Researchers have given this question varying attention, ranging from basic testing techniques, informal monotonicity arguments, thorough pen-and-paper soundness proofs......, to verified fixed point checking. In this paper, we demonstrate how quickchecking can be useful to test a range of static analysis properties with limited effort. We show how to check a range of algebraic lattice properties, to help ensure that an implementation follows the formal specification of a lattice...

  17. 31 CFR 103.29 - Purchases of bank checks and drafts, cashier's checks, money orders and traveler's checks.

    Science.gov (United States)

    2010-07-01

    ... Regulations Relating to Money and Finance FINANCIAL RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN... orders and traveler's checks. (a) No financial institution may issue or sell a bank check or draft... inclusive: (1) If the purchaser has a deposit account with the financial institution: (i)(A) The name of the...

  18. Antibody biotechnology

    African Journals Online (AJOL)

    STORAGESEVER

    2009-07-06

    Jul 6, 2009 ... and automated, the hybrid cells can be stored for many years in liquid nitrogen and antibodies production is homogeneous. The hybridoma method .... they may be modified to vehicle active molecules such as radio-isotopes, toxins, cytokines, enzyme etc. In these cases, the therapeutic effect is due to ...

  19. Catalytic Antibodies

    Indian Academy of Sciences (India)

    The ability of the highly evolved machinery of immune system to produce structurally and functionally complex ... to Pauling, if the structure of the antigen binding site of antibodies were to be produced in a random ..... where the immune system of the body is destructive, as in autoimmune disorders or after organ transplant.

  20. Catalytic Antibodies

    Indian Academy of Sciences (India)

    While chemistry provides the framework for understanding the structure and function of biomolecules, the immune sys- tem provides a highly evolved natural process to generate one class of complex biomolecules – the antibodies. A combination of the two could be exploited to generate new classes of molecules with novel ...

  1. Incremental Integrity Checking: Limitations and Possibilities

    DEFF Research Database (Denmark)

    Christiansen, Henning; Martinenghi, Davide

    2005-01-01

    Integrity checking is an essential means for the preservation of the intended semantics of a deductive database. Incrementality is the only feasible approach to checking and can be obtained with respect to given update patterns by exploiting query optimization techniques. By reducing the problem...

  2. Solar Heating Systems: Progress Checks & Tests Manual.

    Science.gov (United States)

    Green, Joanne; And Others

    This manual contains Progress Checks and Tests for use in a Solar Heating Systems curriculum (see note). It contains master copies of all Progress Checks and Unit Tests accompanying the curriculum, organized by unit. (The master copies are to be duplicated by each school so that adequate copies are available for student use in a self-paced student…

  3. 46 CFR 10.214 - Security Check.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Security Check. 10.214 Section 10.214 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MERCHANT MARINER CREDENTIAL General Requirements for All Merchant Mariner Credentials § 10.214 Security Check. Until April 15, 2009...

  4. Automatization and familiarity in repeated checking

    NARCIS (Netherlands)

    Dek, E.C.P.|info:eu-repo/dai/nl/313959552; van den Hout, M.A.|info:eu-repo/dai/nl/070445354; Giele, C.L.|info:eu-repo/dai/nl/318754460; Engelhard, I.M.|info:eu-repo/dai/nl/239681533

    2015-01-01

    Repetitive, compulsive-like checking of an object leads to reductions in memory confidence, vividness, and detail. Experimental research suggests that this is caused by increased familiarity with perceptual characteristics of the stimulus and automatization of the checking procedure (Dek, van den

  5. Computational Fact Checking by Mining Knowledge Graphs

    Science.gov (United States)

    Shiralkar, Prashant

    2017-01-01

    Misinformation and rumors have become rampant on online social platforms with adverse consequences for the real world. Fact-checking efforts are needed to mitigate the risks associated with the spread of digital misinformation. However, the pace at which information is generated online limits the capacity to fact-check claims at the same rate…

  6. Model Checking Algorithms for Markov Reward Models

    NARCIS (Netherlands)

    Cloth, Lucia; Cloth, L.

    2006-01-01

    Model checking Markov reward models unites two different approaches of model-based system validation. On the one hand, Markov reward models have a long tradition in model-based performance and dependability evaluation. On the other hand, a formal method like model checking allows for the precise

  7. Software tool for physics chart checks.

    Science.gov (United States)

    Li, H Harold; Wu, Yu; Yang, Deshan; Mutic, Sasa

    2014-01-01

    Physics chart check has long been a central quality assurance (QC) measure in radiation oncology. The purpose of this work is to describe a software tool that aims to accomplish simplification, standardization, automation, and forced functions in the process. Nationally recognized guidelines, including American College of Radiology and American Society for Radiation Oncology guidelines and technical standards, and the American Association of Physicists in Medicine Task Group reports were identified, studied, and summarized. Meanwhile, the reported events related to physics chart check service were analyzed using an event reporting and learning system. A number of shortfalls in the chart check process were identified. To address these problems, a software tool was designed and developed under Microsoft. Net in C# to hardwire as many components as possible at each stage of the process. The software consists of the following 4 independent modules: (1) chart check management; (2) pretreatment and during treatment chart check assistant; (3) posttreatment chart check assistant; and (4) quarterly peer-review management. The users were a large group of physicists in the author's radiation oncology clinic. During over 1 year of use the tool has proven very helpful in chart checking management, communication, documentation, and maintaining consistency. The software tool presented in this work aims to assist physicists at each stage of the physics chart check process. The software tool is potentially useful for any radiation oncology clinics that are either in the process of pursuing or maintaining the American College of Radiology accreditation.

  8. Vertical pump with free floating check valve

    International Nuclear Information System (INIS)

    Lindsay, M.

    1980-01-01

    A vertical pump is described which has a bottom discharge with a free floating check valve disposed in the outlet plenum thereof. The free floating check valve comprises a spherical member with a hemispherical cage-like member attached thereto which is capable of allowing forward or reverse flow under appropriate conditions while preventing reverse flow under inappropriate conditions

  9. 38 CFR 21.4505 - Check delivery.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Check delivery. 21.4505...) VOCATIONAL REHABILITATION AND EDUCATION Education Loans § 21.4505 Check delivery. (a) General. Education... surviving spouse is enrolled for delivery by the educational institution. (b) Delivery and certification. (1...

  10. 14 CFR 121.411 - Qualifications: Check airmen (airplane) and check airmen (simulator).

    Science.gov (United States)

    2010-01-01

    ... following— (1) Fly at least two flight segments as a required crewmember for the type airplane involved... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Qualifications: Check airmen (airplane) and... § 121.411 Qualifications: Check airmen (airplane) and check airmen (simulator). (a) For the purposes of...

  11. What is a good health check? An interview study of health check providers' views and practices

    NARCIS (Netherlands)

    Y. Stol (Yrrah); E.C.A. Asscher (Eva); M.H.N. Schermer (Maartje)

    2017-01-01

    markdownabstract__Background:__ Health checks identify (risk factors for) disease in people without symptoms. They may be offered by the government through population screenings and by other providers to individual users as 'personal health checks'. Health check providers' perspective of 'good'

  12. Incremental Integrity Checking: Limitations and Possibilities

    DEFF Research Database (Denmark)

    Christiansen, Henning; Martinenghi, Davide

    2005-01-01

    Integrity checking is an essential means for the preservation of the intended semantics of a deductive database. Incrementality is the only feasible approach to checking and can be obtained with respect to given update patterns by exploiting query optimization techniques. By reducing the problem...... to query containment, we show that no procedure exists that always returns the best incremental test (aka simplification of integrity constraints), and this according to any reasonable criterion measuring the checking effort. In spite of this theoretical limitation, we develop an effective procedure...

  13. Classification and checking model of pedestrian crossing

    Directory of Open Access Journals (Sweden)

    Luis Delgado Méndez

    2012-11-01

    After realizing this investigation it can be confirmed that the functionality of a pedestrian crossing depends on almost a hundred parameters which must be checked or measured, in turn proving that this design and construction process is indeed complex.

  14. Model checking mobile ad hoc networks

    NARCIS (Netherlands)

    Ghassemi, Fatemeh; Fokkink, Wan

    2016-01-01

    Modeling arbitrary connectivity changes within mobile ad hoc networks (MANETs) makes application of automated formal verification challenging. We use constrained labeled transition systems as a semantic model to represent mobility. To model check MANET protocols with respect to the underlying

  15. A Check List for the Reading Teacher.

    Science.gov (United States)

    Gemake, Josephine S.

    1979-01-01

    Presents a check list created by teachers to be used as an evaluation instrument in observations of reading laboratories in the New York City area. Reflects their ideas about the essential components of a remedial reading program. (FL)

  16. Check List: Are You a Gifted Principal?

    Science.gov (United States)

    Taylor, Vicki L.

    1984-01-01

    An 18-item check list is provided for principals to evaluate themselves relative to encouraging gifts and talents of their most able students. Suggestions are given in the areas of educational needs, specialized materials, and counseling. (MC)

  17. Regular Check-Ups Are Important

    Science.gov (United States)

    ... Autumn Tips Camping Tips Family Reunions Gardening Tips Halloween Tips Healthy Halloween Prom Tips Spring Break Valentine Tips Winter Holiday ... Breast Cancer Assess Your Relationships Be Safe on Halloween Be Smoke-Free Check Alarm Batteries Know Your ...

  18. CMM Interim Check Design of Experiments (U)

    Energy Technology Data Exchange (ETDEWEB)

    Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-29

    Coordinate Measuring Machines (CMM) are widely used in industry, throughout the Nuclear Weapons Complex and at Los Alamos National Laboratory (LANL) to verify part conformance to design definition. Calibration cycles for CMMs at LANL are predominantly one year in length and include a weekly interim check to reduce risk. The CMM interim check makes use of Renishaw’s Machine Checking Gauge which is an off-the-shelf product simulates a large sphere within a CMM’s measurement volume and allows for error estimation. As verification on the interim check process a design of experiments investigation was proposed to test a couple of key factors (location and inspector). The results from the two-factor factorial experiment proved that location influenced results more than the inspector or interaction.

  19. checkCIF/PLATON report Datablock: I

    Indian Academy of Sciences (India)

    Mo1 Check. PLAT242_ALERT_2_C Low Ueq as Compared to Neighbors for ..... C12 Check. PLAT342_ALERT_3_C Low Bond Precision on C-C Bonds ............... 0.0112 Ang. PLAT480_ALERT_4_C Long H...A H-Bond Reported H14A .. O2 .. 2.67 Ang. PLAT911_ALERT_3_C Missing # FCF Refl Between THmin & STh/L= ...

  20. checkCIF/PLATON report Datablock: I

    Indian Academy of Sciences (India)

    Alert level B. PLAT094_ALERT_2_B Ratio of Maximum / Minimum Residual Density .... 6.01 Report ... PLAT971_ALERT_2_C Check Calcd Residual Density 1.41A From O6 1.99 eA-3. PLAT971_ALERT_2_C Check ... 3 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 18 ALERT type 2 Indicator that ...

  1. Online treatment compliance checking for clinical pathways.

    Science.gov (United States)

    Huang, Zhengxing; Bao, Yurong; Dong, Wei; Lu, Xudong; Duan, Huilong

    2014-10-01

    Compliance checking for clinical pathways (CPs) is getting increasing attention in health-care organizations due to stricter requirements for cost control and treatment excellence. Many compliance measures have been proposed for treatment behavior inspection in CPs. However, most of them look at aggregated data seen from an external perspective, e.g. length of stay, cost, infection rate, etc., which may provide only a posterior impression of the overall conformance with the established CPs such that in-depth and in near real time checking on the compliance of the essential/critical treatment behaviors of CPs is limited. To provide clinicians real time insights into violations of the established CP specification and support online compliance checking, this article presents a semantic rule-based CP compliance checking system. In detail, we construct a CP ontology (CPO) model to provide a formal grounding of CP compliance checking. Using the proposed CPO, domain treatment constraints are modeled into Semantic Web Rule Language (SWRL) rules to specify the underlying treatment behaviors and their quantified temporal structure in a CP. The established SWRL rules are integrated with the CP workflow such that a series of applicable compliance checking and evaluation can be reminded and recommended during the pathway execution. The proposed approach can, therefore, provides a comprehensive compliance checking service as a paralleling activity to the patient treatment journey of a CP rather than an afterthought. The proposed approach is illustrated with a case study on the unstable angina clinical pathway implemented in the Cardiology Department of a Chinese hospital. The results demonstrate that the approach, as a feasible solution to provide near real time conformance checking of CPs, not only enables clinicians to uncover non-compliant treatment behaviors, but also empowers clinicians with the capability to make informed decisions when dealing with treatment compliance

  2. WE-E-BRB-10: DosCheck - an Electronic Chart Checking Tool for Dosimetrists.

    Science.gov (United States)

    Yang, D; Wu, Y; Yaddanapudi, S; Moore, K; Pierbuxg, B; Brame, S; Mutic, S

    2012-06-01

    In addition to treatment planning, dosimetrists have to prepare documentation and manually enter data in treatment management system (TMS) which did not transfer or setup automatically. The required documents and data are dependent on the disease site, treatment machine and clinical workflow. Errors and inconsistencies can cause redundant work, treatment delays and potentially treatment errors. To address these issues, an electronic checking software tool, DosCheck was clinically implemented to check the existence of necessary documentations and the integrity of manually-entered data. The purpose of this software is to reduce the frequency of human errors and to improve efficiency. DosCheck reads data and documents from 1) TMS, 2) Pinnacle TPS, and 3) DICOM plan files stored in a DICOM-RT PACS. It processes documents in Word and PDF format, treatment plan data in Pinnacle native format and DICOM format, and Mosaiq data in database records. The software cross-checks data accuracy and consistency by following rules that are pre-defined according to the clinical requirements and treatment sties. It interacts with dosimetrists and presents instantaneous results via graphical user interface. DosCheck has been implemented in C#. It performs a full check for a patient with 20 seconds. It has been clinically commissioned and is used daily by all dosimetrists at our institution. Retrospective analysis shows that DosCheck identifies 30% to 40% of previously reported dosimetrist human errors. Additional ∼30% errors are checked by other tools that could be integrated DosCheck in the near future. As an electronic data checking tool, DosCheck can obtain and process data and documents from multiple clinical computer systems in the radiation oncology department, and perform checks according to clinical rules. It is able to improve the accuracy and efficiency of clinical data and document process, and therefore to reduce any potential inconsistencies and errors. © 2012 American

  3. Recent improvements in check valve monitoring methods

    International Nuclear Information System (INIS)

    Haynes, H.D.

    1991-01-01

    In support of the NRC Nuclear Plant Aging Research (NPAR) program, ORNL has carried out an evaluation of three check valve monitoring methods: acoustic emission, ultrasonic inspection, and magnetic flux signature analysis (MFSA). This work has focussed on determining the capabilities of each method to provide diagnostic information useful in determining check valve aging and service wear effects (degradation) and undesirable operating modes. In addition, as part of the ORNL Advanced Diagnostic Engineering Research and Development Center (ADEC), two novel nonintrusive monitoring methods were developed (external ac- and dc-magnetic monitoring) that provide several improvements over the other methods. None of the examined methods could, by themselves, monitor the instantaneous position and motion of check valve internals and valve leakage; however, the combination of acoustic emission monitoring with one of the other methods provides the means to determine vital check valve operational information. This paper describes the benefits and limitations associated with each method and includes recent laboratory and field test data to illustrate the capabilities of these methods to detect simulated check valve degradation. 3 refs., 22 figs., 4 tabs

  4. Recent improvements in check valve monitoring methods

    International Nuclear Information System (INIS)

    Haynes, H.D.

    1990-01-01

    In support of the NRC Nuclear Plant Aging Research (NPAR) program, ORNL has carried out an evaluation of three check valve monitoring methods: acoustic emission, ultrasonic inspection, and magnetic flux signature analysis (MFSA). This work has focused on determining the capabilities of each method to provide diagnostic information useful in determining check valve aging and service wear effects (degradation) and undesirable operating modes. In addition, as part of the ORNL Advanced Diagnostic Engineering Research and Development Center (ADEC), two noval nonintrusive monitoring methods were developed (external ac- and dc-magnetic monitoring) that provide several improvements over the other methods. None of the examined methods could, by themselves, monitor the instantaneous position and motion of check valve internals and valve leakage; however, the combination of acoustic emission monitoring with one of the other methods provides the means to determine vital check valve operational information. This paper describes the benefits and limitations associated with each method and includes recent laboratory and field test data to illustrate the capabilities of these methods to detect simulated check valve degradation. 3 refs., 22 figs., 4 tabs

  5. Evaluation of check valve monitoring methods

    International Nuclear Information System (INIS)

    Haynes, H.D.

    1989-01-01

    Check valves are used extensively in nuclear plant safety systems and balance-of-plant (BOP) systems. Their failures have resulted in significant maintenance efforts and, on occasion, have resulted in water hammer, overpressurization of low-pressure systems and damage to flow system components. Consequently, in recent years check valves have received considerable attention by the Nuclear Regulatory Commission (NRC) and the nuclear power industry. Oak Ridge National Laboratory (ORNL) is carrying out a comprehensive two phase aging assessment of check valves in support of the Nuclear Plant Aging Research (NPAR) program. As part of the second phase, ORNL is evaluating several developmental and/or commercially available check valve diagnostic monitoring methods; in particular, those based on measurements of acoustic emission, ultrasonics, and magnetic flux. These three methods were found to provide different (and complementary) diagnostic information. The combination of acoustic emission with either ultrasonic or magnetic flux monitoring yields a monitoring system that succeeds in providing sensitivity to detect all major check valve operating conditions. All three methods are still under development and should improve in many respects as a result of further testing and evaluation. 10 refs., 19 figs., 1 tab

  6. Terrorist Screening and Brady Background Checks for Firearms

    National Research Council Canada - National Science Library

    Krouse, William J

    2005-01-01

    .... For a time, moreover, all Brady background check records for approved firearm transfers were destroyed almost immediately, precluding the opportunity to used the background check system to screen...

  7. Quality checking of radioactive and hazardous waste

    International Nuclear Information System (INIS)

    Billington, D.M.; Burgoyne, S.M.J.; Dale, C.J.

    1992-01-01

    This report describes the work of the HMIP Waste Quality Checking Laboratory (WQCL) for the period September 1989 -August 1991. The WQCL has conducted research and development of procedures for the receipt, sampling and analysis of low level solid radioactive waste (LLW), intermediate level radioactive waste (ILW) and hazardous chemical waste (HW). Operational facilities have been commissioned for quality checking both LLW and HW. Waste quality checking has been completed on LLW packages seized from the UK waste disposal route by HMIP Inspectors. Packages have ranged in size from the 200 litre steel drum to half-height ISO freight container. Development work was continued on methods of sample extraction and radio-chemical analysis for cement encapsulated ILW in the form of magnox, graphite and stainless steel. This work was undertaken on non-radioactive simulants. (author)

  8. Model checking exact cost for attack scenarios

    DEFF Research Database (Denmark)

    Aslanyan, Zaruhi; Nielson, Flemming

    2017-01-01

    . However, current model checking does not encompass the exact cost analysis of an attack, which is standard for attack trees. Our first contribution is the logic erPCTL with cost-related operators. The extended logic allows to analyse the probability of an event satisfying given cost bounds and to compute......Attack trees constitute a powerful tool for modelling security threats. Many security analyses of attack trees can be seamlessly expressed as model checking of Markov Decision Processes obtained from the attack trees, thus reaping the benefits of a coherent framework and a mature tool support...... the exact cost of an event. Our second contribution is the model checking algorithm for erPCTL. Finally, we apply our framework to the analysis of attack trees....

  9. Glovebox pressure relief and check valve

    International Nuclear Information System (INIS)

    Blaedel, K.L.

    1986-01-01

    This device is a combined pressure relief valve and check valve providing overpressure protection and preventing back flow into an inert atmosphere enclosure. The pressure relief is embodied by a submerged vent line in a mercury reservior, the releif pressure being a function of the submerged depth. The pressure relief can be vented into an exhaust system and the relieving pressure is only slightly influenced by the varying pressure in the exhaust system. The check valve is embodied by a ball which floats on the mercury column and contacts a seat whenever vacuum exists within the glovebox enclosure. Alternatively, the check valve is embodied by a vertical column of mercury, the maximum back pressure being a function of the height of the column of mercury

  10. Glovebox pressure relief and check valve

    Energy Technology Data Exchange (ETDEWEB)

    Blaedel, K.L.

    1986-03-17

    This device is a combined pressure relief valve and check valve providing overpressure protection and preventing back flow into an inert atmosphere enclosure. The pressure relief is embodied by a submerged vent line in a mercury reservior, the releif pressure being a function of the submerged depth. The pressure relief can be vented into an exhaust system and the relieving pressure is only slightly influenced by the varying pressure in the exhaust system. The check valve is embodied by a ball which floats on the mercury column and contacts a seat whenever vacuum exists within the glovebox enclosure. Alternatively, the check valve is embodied by a vertical column of mercury, the maximum back pressure being a function of the height of the column of mercury.

  11. A Framework for Online Conformance Checking

    DEFF Research Database (Denmark)

    Burattin, Andrea; Carmona, Josep

    2017-01-01

    Conformance checking – a branch of process mining – focuses on establishing to what extent actual executions of a process are in line with the expected behavior of a reference model. Current conformancechecking techniques only allow for a-posteriori analysis: the amount of (non-)conformant behavior...... is quantified after the completion of the process instance. In this paper we propose a framework for online conformance checking: not only do we quantify (non-)conformant behavior as the execution is running, we also restrict the computation to constant time complexity per event analyzed, thus enabling...

  12. Engineering Abstractions in Model Checking and Testing

    DEFF Research Database (Denmark)

    Achenbach, Michael; Ostermann, Klaus

    2009-01-01

    Abstractions are used in model checking to tackle problems like state space explosion or modeling of IO. The application of these abstractions in real software development processes, however, lacks engineering support. This is one reason why model checking is not widely used in practice yet...... and testing is still state of the art in falsification. We show how user-defined abstractions can be integrated into a Java PathFinder setting with tools like AspectJ or Javassist and discuss implications of remaining weaknesses of these tools. We believe that a principled engineering approach to designing...

  13. Consistency Checking of Web Service Contracts

    DEFF Research Database (Denmark)

    Cambronero, M. Emilia; Okika, Joseph C.; Ravn, Anders Peter

    2008-01-01

    Behavioural properties are analyzed for web service contracts formulated in Business Process Execution Language (BPEL) and Choreography Description Language (CDL). The key result reported is an automated technique to check consistency between protocol aspects of the contracts. The contracts...... are abstracted to (timed) automata and from there a simulation is set up, which is checked using automated tools for analyzing networks of finite state processes. Here we use the Concurrency Work Bench. The proposed techniques are illustrated with a case study that include otherwise difficult to analyze fault...

  14. A Proof Checking View of Parameterized Complexity

    OpenAIRE

    Mathieson, Luke

    2012-01-01

    The PCP Theorem is one of the most stunning results in computational complexity theory, a culmination of a series of results regarding proof checking it exposes some deep structure of computational problems. As a surprising side-effect, it also gives strong non-approximability results. In this paper we initiate the study of proof checking within the scope of Parameterized Complexity. In particular we adapt and extend the PCP[n log log n, n log log n] result of Feige et al. to several paramete...

  15. A Method for Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Pedersen, Thomas; Le Guilly, Thibaut; Ravn, Anders Peter

    2015-01-01

    This paper presents a method to check for feature interactions in a system assembled from independently developed concurrent processes as found in many reactive systems. The method combines and refines existing definitions and adds a set of activities. The activities describe how to populate the ...... the definitions with models to ensure that all interactions are captured. The method is illustrated on a home automation example with model checking as analysis tool. In particular, the modelling formalism is timed automata and the analysis uses UPPAAL to find interactions....

  16. A Systematic Review of the Empirical Support for Check-in Check-Out

    Science.gov (United States)

    Wolfe, Katie; Pyle, Daniel; Charlton, Cade T.; Sabey, Christian V.; Lund, Emily M.; Ross, Scott W.

    2016-01-01

    Tier 2 interventions play an important role within the Positive Behavioral Interventions and Supports framework, bridging the gap between schoolwide Tier 1 interventions and individualized Tier 3 supports. Check-in Check-out (CICO) is a promising Tier 2 intervention for addressing mild problem behavior and potentially preventing the need for more…

  17. Check In / Check Out. The Public Space as an Internet of Things

    NARCIS (Netherlands)

    van t Hof, C.C.G.; van Est, R.; Daemen, F.

    2011-01-01

    Mobile phones, public transport smart cards, security cameras and GPS systems in our car - we are surrounded by digital devices. They track us, guide us, help us, and control us. The book Check In / Check Out. The Public Space as an Internet of Things shows us how our digital and physical worlds are

  18. What is a good health check? An interview study of health check providers' views and practices.

    Science.gov (United States)

    Stol, Yrrah H; Asscher, Eva C A; Schermer, Maartje H N

    2017-10-02

    Health checks identify (risk factors for) disease in people without symptoms. They may be offered by the government through population screenings and by other providers to individual users as 'personal health checks'. Health check providers' perspective of 'good' health checks may further the debate on the ethical evaluation and possible regulation of these personal health checks. In 2015, we interviewed twenty Dutch health check providers on criteria for 'good' health checks, and the role these criteria play in their practices. Providers unanimously formulate a number of minimal criteria: Checks must focus on (risk factors for) treatable/preventable disease; Tests must be reliable and clinically valid; Participation must be informed and voluntary; Checks should provide more benefits than harms; Governmental screenings should be cost-effective. Aspirational criteria mentioned were: Follow-up care should be provided; Providers should be skilled and experienced professionals that put the benefit of (potential) users first; Providers should take time and attention. Some criteria were contested: People should be free to test on any (risk factor for) disease; Health checks should only be performed in people at high risk for disease that are likely to implement health advice; Follow up care of privately funded tests should not drain on collective resources. Providers do not always fulfil their own criteria. Their reasons reveal conflicts between criteria, conflicts between criteria and other ethical values, and point to components in the (Dutch) organisation of health care that hinder an ethical provision of health checks. Moreover, providers consider informed consent a criterion that is hard to establish in practice. According to providers, personal health checks should meet the same criteria as population screenings, with the exception of cost-effectiveness. Providers do not always fulfil their own criteria. Results indicate that in thinking about the ethics of health

  19. Do intrauterine device/intrauterine system users check their threads?

    Science.gov (United States)

    Davies, Amanda; Fleming, Charlotte

    2014-04-01

    Expulsion of an intrauterine device (IUD) occurs in about 1 in 20 women and expulsion may not be noticed by the user. Current guidance recommends that users are instructed to check regularly for their threads. This is the first study to explore the reality of how women feel about checking their threads and the details surrounding how frequently checks are done. One hundred consecutive IUD users were interviewed regarding their type of device, duration of use, frequency of thread checking, prompts for checking and reasons for not checking. Only 23% checked their threads regularly and 51% had never done so. The most common reason for not checking was forgetting about it. Despite being advised to do so, the majority of users do not check their threads at all and fewer than one-quarter of them check regularly. We propose that advice offered about thread checking should be given less emphasis and suggested more for user reassurance.

  20. checkCIF/PLATON report Datablock: I

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  1. checkCIF/PLATON report Datablock: shelxl

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. Structure factors have been supplied for datablock(s) shelxl. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax ...

  2. checkCIF/PLATON report Datablock: I

    Indian Academy of Sciences (India)

    PLAT912_ALERT_4_G Missing # of FCF Reflections Above STh/L= 0.600. 38. 0 ALERT level A = Most likely a serious problem - resolve or explain. 0 ALERT level B = A potentially serious problem, consider carefully. 6 ALERT level C = Check. Ensure it is not caused by an omission or oversight. 10 ALERT level G = General ...

  3. Model checking the HAVi leader election protocol

    NARCIS (Netherlands)

    J.M.T. Romijn (Judi)

    1999-01-01

    textabstractThe HAVi specification proposes an architecture for audio/video interoperability in home networks. Part of the HAVi specification is a distributed leader election protocol. We have modelled this leader election protocol in Promela and Lotos and have checked several properties with the

  4. Posterior Predictive Model Checking in Bayesian Networks

    Science.gov (United States)

    Crawford, Aaron

    2014-01-01

    This simulation study compared the utility of various discrepancy measures within a posterior predictive model checking (PPMC) framework for detecting different types of data-model misfit in multidimensional Bayesian network (BN) models. The investigated conditions were motivated by an applied research program utilizing an operational complex…

  5. 7 CFR 58.243 - Checking quality.

    Science.gov (United States)

    2010-01-01

    ... Procedures § 58.243 Checking quality. All milk, milk products and dry milk products shall be subject to inspection and analysis by the dairy plant for quality and condition throughout each processing operation... aid to quality control in addition to the regular routine analysis made on the finished products. ...

  6. checkCIF/PLATON report Datablock: 1

    Indian Academy of Sciences (India)

    1 ALERT level G = General information/check it is not something unexpected. 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 1 ALERT type 2 Indicator that the structure model may be wrong or deficient. 0 ALERT type 3 Indicator that the structure quality may be low. 1 ALERT type 4 Improvement, ...

  7. checkCIF/PLATON report Datablock: shelxl

    Indian Academy of Sciences (India)

    6 ALERT level G = General information/check it is not something unexpected. 1 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 15 ALERT type 2 Indicator that the structure model may be wrong or deficient. 9 ALERT type 3 Indicator that the structure quality may be low. 1 ALERT type 4 Improvement, ...

  8. Jig Quickly Checks Connector Pin Alinement

    Science.gov (United States)

    Hall, W. M.; Papac, T. P.

    1983-01-01

    Test jig checks whether pins of connector are within location tolerance. Jig greatly reduces test time. Machined slots on opposite faces of plate form matrix of rectangular windows at intersections. If connector pin is out of alinement, it makes electrical contact with side of window, triggering indicator.

  9. Streaming Process Discovery and Conformance Checking

    DEFF Research Database (Denmark)

    Burattin, Andrea

    2018-01-01

    Streaming process discovery, streaming conformance checking, and streaming process mining in general (also known as online process mining) are disciplines which analyze event streams to extract a process model or to assess their conformance with respect to a given reference model. The main...

  10. checkCIF/PLATON report Datablock: shelx

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. Structure factors have been supplied for datablock(s) shelx. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors ...

  11. Model Checking Dynamic States in GROOVE

    NARCIS (Netherlands)

    Kastenberg, H.; Rensink, Arend; Valmari, A.

    2006-01-01

    Much research has been done in the field of model-checking complex systems (either hardware or software). Approaches that use explicit state modelling mostly use bit vectors to represent the states of such systems. Unfortunately, that kind of representation does not extend smoothly to systems in

  12. A Method for Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Pedersen, Thomas; Le Guilly, Thibaut; Ravn, Anders Peter

    2015-01-01

    This paper presents a method to check for feature interactions in a system assembled from independently developed concurrent processes as found in many reactive systems. The method combines and refines existing definitions and adds a set of activities. The activities describe how to populate the ...

  13. checkCIF/PLATON report Datablock: 1

    Indian Academy of Sciences (India)

    (Positive) Residual Density 13.61 eA-3. PLAT201_ALERT_2_B Isotropic non-H Atoms in Main Residue(s) . ... Weight Differ by .. 4.99 Check. PLAT094_ALERT_2_C Ratio of Maximum / Minimum Residual Density . ... 9 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 20 ALERT type 2 Indicator that ...

  14. Model Checking - Automated Verification of Computational Systems

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 7. Model Checking - Automated Verification of Computational Systems. Madhavan Mukund. General Article Volume 14 Issue 7 July 2009 pp 667-681. Fulltext. Click here to view fulltext PDF. Permanent link:

  15. checkCIF/PLATON report Datablock: aa

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  16. checkCIF/PLATON report Datablock: Sm

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  17. checkCIF/PLATON report Datablock: 2

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  18. checkCIF/PLATON report Datablock: 5

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  19. checkCIF/PLATON report Datablock: shelx

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  20. checkCIF/PLATON report Datablock: neu

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  1. checkCIF/PLATON report Datablock: shelxl

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  2. checkCIF/PLATON report Datablock: 6

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  3. checkCIF/PLATON report Datablock: platon

    Indian Academy of Sciences (India)

    serious of these should normally be commented upon in the discussion or experimental section of a paper or in the "special_details" fields of the CIF. checkCIF was carefully designed to identify outliers and unusual parameters, but every test has its limitations and alerts that are not important in a particular case may appear.

  4. Discrete-time rewards model-checked

    NARCIS (Netherlands)

    Larsen, K.G.; Andova, S.; Niebert, Peter; Hermanns, H.; Katoen, Joost P.

    2003-01-01

    This paper presents a model-checking approach for analyzing discrete-time Markov reward models. For this purpose, the temporal logic probabilistic CTL is extended with reward constraints. This allows to formulate complex measures – involving expected as well as accumulated rewards – in a precise and

  5. checkCIF/PLATON report Datablock: sm

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  6. Check list of European Hymenomycetous Heterobasidiae

    NARCIS (Netherlands)

    Donk, M.A.

    1966-01-01

    With this check list an attempt is made to account for the recorded European species of those Basidiomycetes that Patouillard called the “Hétérobasidies”, excluding, however, the Uredinales and Ustilaginales. Therefore, it covers the Septobasidiales, Tremellales (comprising the Auriculariineae and

  7. Statistical Model Checking for Stochastic Hybrid Systems

    DEFF Research Database (Denmark)

    David, Alexandre; Du, Dehui; Larsen, Kim Guldstrand

    2012-01-01

    This paper presents novel extensions and applications of the UPPAAL-SMC model checker. The extensions allow for statistical model checking of stochastic hybrid systems. We show how our race-based stochastic semantics extends to networks of hybrid systems, and indicate the integration technique ap...

  8. checkCIF/PLATON report Datablock: shelxl

    Indian Academy of Sciences (India)

    Author Response: This Alert is due to low quality data and higher values of thermal parameters. PLAT241_ALERT_2_C High Ueq as Compared to Neighbors for ..... C12 Check. Author Response: This Alert is due to low quality data and higher values of thermal parameters. PLAT242_ALERT_2_C Low Ueq as Compared to ...

  9. Calibration Check For Programmed Welding Robot

    Science.gov (United States)

    Sliwinski, Karen E.; Anderson, Ronald R.; Osterloh, Mark R.

    1992-01-01

    Preweld calibration check helps to ensure welding torch on computer-controlled welding robot mounted properly, right gas cup selected, and length of extension of electrode adjusted correctly. Performed by operator just before dry run for each set of parts welded. Procedure takes 2 to 3 minutes and enables correction of errors before parts or equipment damaged.

  10. Availability of a Renewable, Checked System

    DEFF Research Database (Denmark)

    Platz, O.

    1976-01-01

    Recurrent expressions are given for point and interval unavailability of a renewable system subjected to periodic checking/repair. The expressions are generalizations of the basic relations in the theory of discrete renewal processes. The asymptotic limits for long times follow simply from a gene...

  11. checkCIF/PLATON report Datablock: I

    Indian Academy of Sciences (India)

    PLAT918_ALERT_3_C Reflection(s) with I(obs) much smaller I(calc) . 1 Check. Alert level G ... 7 ALERT level A = Data missing that is essential or data in wrong format. 1 ALERT level G = General alerts. ... problems it may be necessary to carry out additional measurements or structure refinements. However, the nature of ...

  12. checkCIF/PLATON report Datablock: 1

    Indian Academy of Sciences (India)

    0 ALERT level B = A potentially serious problem, consider carefully. 1 ALERT level C = Check. Ensure it ... 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 1 ALERT type 2 Indicator that the .... CELLZ01_ALERT_1_G WARNING: H atoms missing from atom site list. Is this intentional? From the CIF: ...

  13. Type checking with open type functions

    DEFF Research Database (Denmark)

    Schrijvers, Tom; Jones, Simon Peyton; Chakravarty, Manual

    2008-01-01

    We report on an extension of Haskell with open type-level functions and equality constraints that unifies earlier work on GADTs, functional dependencies, and associated types. The contribution of the paper is that we identify and characterise the key technical challenge of entailment checking...

  14. Separation of Powers: Checks and Balances.

    Science.gov (United States)

    Taylor, Bonnie

    1988-01-01

    This article offers a class activity on separation of powers and checks and balances within the U.S. government. Based on Franklin Delano Roosevelt's attempt to push through legislation for the New Deal of the 1930s by "packing" the U.S. Supreme Court, the activity includes worksheets and teaching suggestions. (JDH)

  15. checkCIF/PLATON report Datablock: 8

    Indian Academy of Sciences (India)

    PLAT306_ALERT_2_B Isolated Oxygen Atom (H-atoms Missing ?) ....... O3 Check. PLAT340_ALERT_3_B Low Bond Precision on C-C Bonds ............... 0.01627 Ang. Alert level C. ABSTY02_ALERT_1_C An _exptl_absorpt_correction_type has been given without a literature citation. This should be contained in the.

  16. checkCIF/PLATON report Datablock: shelx

    Indian Academy of Sciences (India)

    7 ALERT level G = General information/check it is not something unexpected. 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 3 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  17. checkCIF/PLATON report Datablock: shelx

    Indian Academy of Sciences (India)

    7 ALERT level G = General information/check it is not something unexpected. 1 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 2 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  18. checkCIF/PLATON report Datablock: 1

    Indian Academy of Sciences (India)

    6 ALERT level G = General information/check it is not something unexpected. 2 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 8 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  19. checkCIF/PLATON report Datablock: 3

    Indian Academy of Sciences (India)

    5 ALERT level G = General information/check it is not something unexpected. 5 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 15 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  20. checkCIF/PLATON report Datablock: 1

    Indian Academy of Sciences (India)

    9 ALERT level G = General information/check it is not something unexpected. 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 14 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  1. checkCIF/PLATON report Datablock: 3

    Indian Academy of Sciences (India)

    5 ALERT level G = General information/check it is not something unexpected. 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 3 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  2. checkCIF/PLATON report Datablock: shelxl

    Indian Academy of Sciences (India)

    6 ALERT level G = General information/check it is not something unexpected. 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 4 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  3. checkCIF/PLATON report Datablock: aa

    Indian Academy of Sciences (India)

    20 ALERT level G = General information/check it is not something unexpected. 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 10 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  4. Automata-Based CSL Model Checking

    DEFF Research Database (Denmark)

    Zhang, Lijun; Jansen, David N.; Nielson, Flemming

    2011-01-01

    For continuous-time Markov chains, the model-checking problem with respect to continuous-time stochastic logic (CSL) has been introduced and shown to be decidable by Aziz, Sanwal, Singhal and Brayton in 1996. The presented decision procedure, however, has exponential complexity. In this paper, we...

  5. 31 CFR 235.4 - Check Forgery Insurance Fund.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Check Forgery Insurance Fund. 235.4 Section 235.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... CHECKS DRAWN ON DESIGNATED DEPOSITARIES § 235.4 Check Forgery Insurance Fund. The Check Forgery Insurance...

  6. Study of check image using computed radiography

    International Nuclear Information System (INIS)

    Sato, Hiroshi

    2002-01-01

    There are two image forming methods both a check image and a portal image in the linacogram. It has been established the image forming method in the check image using computed radiography (CR). On the other hand, it is not established the image forming method in the portal image using CR yet. Usually, in the electric portal imaging device (EPID) is mainly used just before radiotherapy start. The usefulness of the portal image forming method by CR using in place of EPID is possible to confirm the precision for determining to specific position at the irradiate part and to the irradiate method for the human organs. There are some technical problems that, since in the early time, the linac graphy (LG) image have low resolution power. In order to improve to the resolution power in LG image, CR image technologies have been introduced to the check image forming method. Heavy metallic sheet (HMS) is used to the front side of CR-IP cassette, and high contactness sponge is used to the back side of the cassette. Improved contactness between HMS and imaging plate (IP) by means of the high contactness sponge contributed to improve the resolution power in the check images. A lot of paper which is connected with these information have been reported. Imaging plate ST-III should be used to maintain high sensitivity in the check film image forming method. The same image forming method in the check image established by CR has been introduced into the portal image forming method in order to improve the resolution power. However, as a result, it couldn't acquired high resolution image forming in the portal images because of the combination of ST-III and radiotherapy dose. After several trials, it has been recognized that HR-V imaging plate for mammography is the most useful application to maintain high resolution power in the portal images. Also, it is possible to modify the image quality by changing GS parameter which is one of image processing parameters in CR. Furthermore, in case

  7. Check-Up Checklist: Things to Do Before Your Next Check-Up

    Science.gov (United States)

    ... Autumn Tips Camping Tips Family Reunions Gardening Tips Halloween Tips Healthy Halloween Prom Tips Spring Break Valentine Tips Winter Holiday ... Breast Cancer Assess Your Relationships Be Safe on Halloween Be Smoke-Free Check Alarm Batteries Know Your ...

  8. Clamp force and alignment checking device

    Science.gov (United States)

    Spicer, John Patrick; Cai, Wayne W.; Chakraborty, Debejyo; Mink, Keith

    2017-04-11

    A check fixture measures a total clamp force applied by a welder device. The welder device includes a welding horn having a plurality of weld pads and welding anvil having a plurality of weld pads. The check fixture includes a base member operatively supporting a plurality of force sensors. The base member and the force sensors are received between the weld pads of the welding horn and the anvil pads of the welding anvil. Each force sensor is configured to measure an individual clamp force applied thereto by corresponding weld and anvil pads when the base member is received between the welding horn and the welding anvil and the welder device is in the clamped position. The individual clamp forces are used to determine whether the weld and/or anvil pads are worn or misaligned.

  9. Model Checking as Static Analysis: Revisited

    DEFF Research Database (Denmark)

    Zhang, Fuyuan; Nielson, Flemming; Nielson, Hanne Riis

    2012-01-01

    We show that the model checking problem of the μ-calculus can be viewed as an instance of static analysis. We propose Succinct Fixed Point Logic (SFP) within our logical approach to static analysis as an extension of Alternation-free Least Fixed Logic (ALFP). We generalize the notion of stratific......We show that the model checking problem of the μ-calculus can be viewed as an instance of static analysis. We propose Succinct Fixed Point Logic (SFP) within our logical approach to static analysis as an extension of Alternation-free Least Fixed Logic (ALFP). We generalize the notion...... of stratification to weak stratification and establish a Moore Family result for the new logic as well. The semantics of the μ-calculus is encoded as the intended model of weakly stratified clause sequences in SFP....

  10. Optimal database locks for efficient integrity checking

    DEFF Research Database (Denmark)

    Martinenghi, Davide

    2004-01-01

    the execution of update transactions. Several methods for efficient integrity checking and enforcing exist. We show in this paper how to apply one such method to automatically extend update transactions with locks and simplified consistency tests on the locked entities. All schedules produced in this way...... are conflict serializable and preserve consistency. For certain classes of databases we also guarantee that the amount of locked database entities is minimal....

  11. Speed checks on the CERN site

    CERN Multimedia

    2007-01-01

    In view of the significant number of speeding incidents that have been reported, CERN will shortly start to carry out speed checks on the site. The radar used for this purpose will show drivers the speed measured. The disciplinary measures taken against those exceeding the authorised limit (generally 50 k.p.h.) will include a ban from driving on the site for a minimum of one month. Maximilian Metzger
Secretary-General

  12. Posterior predictive checking of multiple imputation models.

    Science.gov (United States)

    Nguyen, Cattram D; Lee, Katherine J; Carlin, John B

    2015-07-01

    Multiple imputation is gaining popularity as a strategy for handling missing data, but there is a scarcity of tools for checking imputation models, a critical step in model fitting. Posterior predictive checking (PPC) has been recommended as an imputation diagnostic. PPC involves simulating "replicated" data from the posterior predictive distribution of the model under scrutiny. Model fit is assessed by examining whether the analysis from the observed data appears typical of results obtained from the replicates produced by the model. A proposed diagnostic measure is the posterior predictive "p-value", an extreme value of which (i.e., a value close to 0 or 1) suggests a misfit between the model and the data. The aim of this study was to evaluate the performance of the posterior predictive p-value as an imputation diagnostic. Using simulation methods, we deliberately misspecified imputation models to determine whether posterior predictive p-values were effective in identifying these problems. When estimating the regression parameter of interest, we found that more extreme p-values were associated with poorer imputation model performance, although the results highlighted that traditional thresholds for classical p-values do not apply in this context. A shortcoming of the PPC method was its reduced ability to detect misspecified models with increasing amounts of missing data. Despite the limitations of posterior predictive p-values, they appear to have a valuable place in the imputer's toolkit. In addition to automated checking using p-values, we recommend imputers perform graphical checks and examine other summaries of the test quantity distribution. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. checkCIF/PLATON report Datablock: shelx

    Indian Academy of Sciences (India)

    PLAT340_ALERT_3_C Low Bond Precision on C-C Bonds ............... 0.0048 Ang. PLAT410_ALERT_2_C Short Intra H...H Contact H10A .. H11A .. 1.99 Ang. Alert level G. PLAT032_ALERT_4_G Std. Uncertainty on Flack Parameter Value High . 1.000 Why ? PLAT333_ALERT_2_G Check Large Av C6-Ring C-C Dist. C1 -C6.

  14. Delivery quality assurance with ArcCHECK

    Energy Technology Data Exchange (ETDEWEB)

    Neilson, Christopher; Klein, Michael; Barnett, Rob [London Regional Cancer Program, London Health Sciences Centre, London, Ontario (Canada); Yartsev, Slav, E-mail: slav.yartsev@lhsc.on.ca [London Regional Cancer Program, London Health Sciences Centre, London, Ontario (Canada)

    2013-04-01

    Radiation therapy requires delivery quality assurance (DQA) to ensure that treatment is accurate and closely follows the plan. We report our experience with the ArcCHECK phantom and investigate its potential optimization for the DQA process. One-hundred seventy DQA plans from 84 patients were studied. Plans were classified into 2 groups: those with the target situated on the diodes of the ArcCHECK (D plans) and those with the target situated at the center (C plans). Gamma pass rates for 8 target sites were examined. The parameters used to analyze the data included 3%/3 mm with the Van Dyk percent difference criteria (VD) on, 3%/3 mm with the VD off, 2%/2 mm with the VD on, and x/3 mm with the VD on and the percentage dosimetric agreement “x” for diode plans adjusted. D plans typically displayed maximum planned dose (MPD) on the cylindrical surface containing ArcCHECK diodes than center plans, resulting in inflated gamma pass rates. When this was taken into account by adjusting the percentage dosimetric agreement, C plans outperformed D plans by an average of 3.5%. ArcCHECK can streamline the DQA process, consuming less time and resources than radiographic films. It is unnecessary to generate 2 DQA plans for each patient; a single center plan will suffice. Six of 8 target sites consistently displayed pass rates well within our acceptance criteria; the lesser performance of head and neck and spinal sites can be attributed to marginally lower doses and increased high gradient of plans.

  15. checkCIF/PLATON report Datablock: codadm

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. No syntax errors found. CIF dictionary Interpreting this report. Datablock: codadm. Bond precision: C-C = 0.0029 A. Wavelength=0.71073. Cell: a=33.127(2) b=12.6267(9) c=25.1845(17) alpha=90.

  16. checkCIF/PLATON report Datablock: platon

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. Structure factors have been supplied for datablock(s) platon. No syntax errors found. CIF dictionary Interpreting this report. Datablock: platon. Bond precision: C-C = 0.0033 A. Wavelength=0.71073. Cell: a=16.345(7) b=6.288(3) c=19.938(8) alpha=90 beta=96.169(7) gamma=90. Temperature:.

  17. checkCIF/PLATON report Datablock: I

    Indian Academy of Sciences (India)

    4.0 prolat. PLAT220_ALERT_2_C Large Non-Solvent O Ueq(max)/Ueq(min) Range. 4.0 Ratio. PLAT241_ALERT_2_C High 'MainMol' Ueq as Compared to Neighbors of. O1 Check. PLAT341_ALERT_3_C Low Bond Precision on C-C Bonds ............... 0.01217 Ang. PLAT906_ALERT_3_C Large K value in the Analysis of ...

  18. checkCIF/PLATON report Datablock: s

    Indian Academy of Sciences (India)

    130 Do ! N2 -CO1 -N4 -C51 132.00 2.00 1.555 1.555 1.555 1.555. PLAT899_ALERT_4_G SHELXL97 is Deprecated and Succeeded by SHELXL 2014 Note. 0 ALERT level A = Most likely a serious problem - resolve or explain. 0 ALERT level B = A potentially serious problem, consider carefully. 10 ALERT level C = Check.

  19. Check valves with drop-shaped disk

    Energy Technology Data Exchange (ETDEWEB)

    1943-03-19

    This report discusses improvements possible with drop check valves. Up to the time of the report, the most important improvements had been: (1) lightening of the drop by hollowing it out, (2) reducing lift to reduce impact, (3) increasing clearance in the guide to minimize the danger of it getting stuck, (4) drilling of a safety hole which would indicate excessive wear of the housing by a leak. Other possibilities for the above improvements had produced the following conclusions: (1) a further lightening of the drop was found possible by milling out the halves with a milling cutter, by welding them together and thus eliminating the threaded portion, or by having the drop open on the bottom; (2) further reduction in lift was not found possible in most sizes, but for reduction of the impact effect by a cushion of oil or paste, the seating surface was widened as much as possible; (3) sticking of certain check valves caused by ferrous sulfide deposits could be solved by use of a certain bushing in the housing; (4) some plants favored and some disfavored the safety hole, but in general, plants were to service check valves and change them at such regular intervals as experience dictated; (5) the seat plate was no longer solid steel, but a welded piece.

  20. Reality check: the cost-effectiveness of removing body checking from youth ice hockey.

    Science.gov (United States)

    Lacny, Sarah; Marshall, Deborah A; Currie, Gillian; Kulin, Nathalie A; Meeuwisse, Willem H; Kang, Jian; Emery, Carolyn A

    2014-09-01

    The risk of injury among Pee Wee (ages 11-12 years) ice hockey players in leagues that allow body checking is threefold greater than in leagues that do not allow body checking. We estimated the cost-effectiveness of a no body checking policy versus a policy that allows body checking in Pee Wee ice hockey. Cost-effectiveness analysis alongside a prospective cohort study during the 2007-2008 season, including players in Quebec (n=1046), where policy did not allow body checking, and in Alberta (n=1108), where body checking was allowed. Injury incidence rates (injuries/1000 player-hours) and incidence proportions (injuries/100 players), adjusted for cluster using Poisson regression, allowed for standardised comparisons and meaningful translation to community stakeholders. Based on Alberta fee schedules, direct healthcare costs (physician visits, imaging, procedures) were adjusted for cluster using bootstrapping. We examined uncertainty in our estimates using cost-effectiveness planes. Associated with significantly higher injury rates, healthcare costs where policy allowed body checking were over 2.5 times higher than where policy disallowed body checking ($C473/1000 player-hours (95% CI $C358 to $C603) vs $C184/1000 player-hours (95% CI $C120 to $C257)). The difference in costs between provinces was $C289/1000 player-hours (95% CI $C153 to $C432). Projecting results onto Alberta Pee Wee players registered in the 2011-2012 season, an estimated 1273 injuries and $C213 280 in healthcare costs would be avoided during just one season with the policy change. Our study suggests that a policy disallowing body checking in Pee Wee ice hockey is cost-saving (associated with fewer injuries and lower costs) compared to a policy allowing body checking. As we did not account for long-term outcomes, our results underestimate the economic impact of these injuries. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please

  1. Acetylcholine receptor antibody

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003576.htm Acetylcholine receptor antibody To use the sharing features on this page, please enable JavaScript. Acetylcholine receptor antibody is a protein found in the blood ...

  2. Platelet antibodies blood test

    Science.gov (United States)

    This blood test shows if you have antibodies against platelets in your blood. Platelets are a part of the blood ... Chernecky CC, Berger BJ. Platelet antibody - blood. In: Chernecky ... caused by platelet destruction, hypersplenism, or hemodilution. ...

  3. Quantum anonymous voting with anonymity check

    International Nuclear Information System (INIS)

    Horoshko, Dmitri; Kilin, Sergei

    2011-01-01

    We propose a new protocol for quantum anonymous voting having serious advantages over the existing protocols: it protects both the voters from a curious tallyman and all the participants from a dishonest voter in unconditional way. The central idea of the protocol is that the ballots are given back to the voters after the voting process, which gives a possibility for two voters to check the anonymity of the vote counting process by preparing a special entangled state of two ballots. Any attempt of cheating from the side of the tallyman results in destroying the entanglement, which can be detected by the voters.

  4. Statistical Model Checking for Biological Systems

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Legay, Axel

    2014-01-01

    Statistical Model Checking (SMC) is a highly scalable simulation-based verification approach for testing and estimating the probability that a stochastic system satisfies a given linear temporal property. The technique has been applied to (discrete and continuous time) Markov chains, stochastic...... timed automata and most recently hybrid systems using the tool Uppaal SMC. In this paper we enable the application of SMC to complex biological systems, by combining Uppaal SMC with ANIMO, a plugin of the tool Cytoscape used by biologists, as well as with SimBiology®, a plugin of Matlab to simulate...

  5. Statically checked documentation with design patterns

    DEFF Research Database (Denmark)

    Cornils, Aino; Hedin, Görel

    2000-01-01

    Over the past years, along with the increase in popularity of design patterns, some problems with the use of design patterns have been identified. The so-called tracing problem describes the difficulty in documenting software systems using design patterns. Initial approaches to solving the tracin...... present a flexible and extensible tool which enables designers to use design patterns in a safe and efficient way, which checks the design pattern rules, and which semi-automatically documents, and maintains the documentation of a software system...

  6. Political and judicial checks on corruption

    DEFF Research Database (Denmark)

    Alt, James E.; Lassen, David Dreyer

    2008-01-01

    This paper investigates the effects of checks and balances on corruption. Within a presidential system, effective separation of powers is achieved under a divided government, with the executive and legislative branches being controlled by different political parties. When government is unified......, no effective separation exists even within a presidential system, but, we argue, can be partially restored by having an accountable judiciary. Our empirical findings show that a divided government and elected, rather than appointed, state supreme court judges are associated with lower corruption and...

  7. Non intrusive check valve diagnostics at Bruce A

    International Nuclear Information System (INIS)

    Marsch, S.P.

    1997-01-01

    Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

  8. Non intrusive check valve diagnostics at Bruce A

    Energy Technology Data Exchange (ETDEWEB)

    Marsch, S.P. [Ontario Hydro, Bruce Nuclear Generating Station A, Tiverton, ON (Canada)

    1997-07-01

    Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

  9. Molecular double-check strategy for the identification and characterization of European Lyssaviruses

    DEFF Research Database (Denmark)

    Fischer, Melina; Freuling, Conrad M.; Müller, Thomas

    2014-01-01

    The “gold standard” for post-mortem rabies diagnosis is the direct fluorescent antibody test (FAT). However, in the case of ante-mortem non-neural sample material or decomposed tissues, the FAT reaches its limit, and the use of molecular techniques can be advantageous. In this study, we developed......-systems for Rabies virus, European bat lyssavirus type 1 and 2 as well as Bokeloh bat lyssavirus. All assays were validated successfully with a comprehensive panel of lyssavirus positive samples, as well as negative material from various host species. This double-check strategy allows for both safe and sensitive...

  10. Polarity Checks in Sectors 23 & 78

    CERN Document Server

    Calaga, R; Lamont, M; Ponce, L; Sun, Y; Tomás, R; Venturini-Delsolaro, W; Zimmermann, F

    2009-01-01

    During the first three LHC synchronization tests on August 10, August 24, and September 7, 2008, linear and higher-order polarity checks were performed with beam 1 in Sector 23 and beam 2 in Sector 78. The main principle of these checks was to launch free betatron oscillations and use the difference trajectory measurements with respect to inverted polarities of circuits under investigation. In the case of zero nominal strength for a circuit, a finite value was introduced. The magnet circuits subjected to these tests were the QT and QTL trim quadrupoles, the MQS skew quadrupoles, the SF and SD arc sextupole circuits, the MCS b3 spool pieces, the OD and OF Landau octupoles, and the MSS skew sextupoles. For some of these circuits sensitivity was enhanced by introducing large momentum offsets. To detect and remove improve spurious contributions from initially off-center orbits, four sets of trajectories were recorded, namely with and without oscillation, and with two magnet strength settings, respectively. We rep...

  11. Monoclonal antibodies and cancer

    International Nuclear Information System (INIS)

    Haisma, H.J.

    1987-01-01

    The usefulness of radiolabeled monoclonal antibodies for imaging and treatment of human (ovarian) cancer was investigated. A review of tumor imaging with monoclonal antibodies is presented. Special attention is given to factors that influence the localization of the antibodies in tumors, isotope choice and methods of radiolabeling of the monoclonal antibodies. Two monoclonal antibodies, OC125 and OV-TL3, with high specificity for human epithelial ovarian cancer are characterized. A simple radio-iodination technique was developed for clinical application of the monoclonal antibodies. The behavior of monoclonal antibodies in human tumor xenograft systems and in man are described. Imaging of tumors is complicated because of high background levels of radioactivity in other sites than the tumor, especially in the bloodpool. A technique was developed to improve imaging of human tumor xenographs in nude mice, using subtraction of a specific and a non-specific antibody, radiolabeled with 111 In, 67 Ga and 131 I. To investigate the capability of the two monoclonal antibodies, to specifically localize in human ovarian carcinomas, distribution studies in mice bearing human ovarian carcinoma xenografts were performed. One of the antibodies, OC125, was used for distribution studies in ovarian cancer patients. OC125 was used because of availability and approval to use this antibody in patients. The same antibody was used to investigate the usefulness of radioimmunoimaging in ovarian cancer patients. The interaction of injected radiolabeled antibody OC125 with circulating antigen and an assay to measure the antibody response in ovarian cancer patients after injection of the antibody is described. 265 refs.; 30 figs.; 19 tabs

  12. 76 FR 16861 - Availability of Funds and Collection of Checks

    Science.gov (United States)

    2011-03-25

    ... learning whether a deposited check has been returned unpaid. DATES: Comments on the proposed rule must be... . Overview of the Proposal I. Amendments To Encourage Electronic Check Clearing and Check Return As a general...)--Automated Teller Machine or ATM The Board proposes to clarify that an automated teller machine (ATM...

  13. 40 CFR 86.327-79 - Quench checks; NOX analyzer.

    Science.gov (United States)

    2010-07-01

    ... any flow rate into the reaction chamber. This includes, but is not limited to, sample capillary, ozone... Quench checks; NOX analyzer. (a) Perform the reaction chamber quench check for each model of high vacuum reaction chamber analyzer prior to initial use. (b) Perform the reaction chamber quench check for each new...

  14. 45 CFR 201.70 - Treatment of replacement checks.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Treatment of replacement checks. 201.70 Section... STATES FOR PUBLIC ASSISTANCE PROGRAMS Review and Audits § 201.70 Treatment of replacement checks. (a... (FFP) for replacement checks under titles I, VI-A, X, XIV, XVI (AABD) except under the circumstances...

  15. Check & Connect: A Comprehensive Student Engagement Intervention Manual

    Science.gov (United States)

    Christenson, Sandra L.; Thurlow, Martha L.; Sinclair, Mary F.; Lehr, Camilla A.; Kaibel, Colleen M.; Reschly, Amy L.; Mavis, Ann; Pohl, Angie

    2008-01-01

    Check & Connect was created in a five year period from 1990 to 1995. The original manual, entitled "Keeping Kids in School: Using Check & Connect for Dropout Prevention" and written by David Evelo, Mary Sinclair, Christine Hurley, Sandra Christenson, and Martha Thurlow, was published in 1996 (ED398701). This newly revised Check & Connect manual…

  16. 12 CFR 229.36 - Presentment and issuance of checks.

    Science.gov (United States)

    2010-01-01

    ... Section 229.36 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Collection of Checks § 229... on the check, whether in magnetic ink or in fractional form; (3) At any branch or head office, if the...

  17. Radiolabeled antibody imaging

    International Nuclear Information System (INIS)

    Wahl, R.L.

    1987-01-01

    Radiolabeled antibodies, in particular monoclonal antibodies, offer the potential for the specific nuclear imaging of malignant and benign diseases in man. If this imaging potential is realized, they may also have a large role in cancer treatment. This paper reviews: (1) what monoclonal antibodies are and how they differ from polyclonal antibodies, (2) how they are produced and radiolabeled, (3) the results of preclinical and clinical trials in cancer imaging, including the utility of SPECT and antibody fragments, (4) the role of antibodies in the diagnosis of benign diseases, (5) alternate routes of antibody delivery, (6) the role of these agents in therapy, and (7) whether this technology ''revolutionizes'' the practice of nuclear radiology, or has a more limited complementary role in the imaging department

  18. Checking in: An Analysis of the (Lack of) Body Checking in Women's Ice Hockey

    Science.gov (United States)

    Weaving, Charlene; Roberts, Samuel

    2012-01-01

    Despite the growing popularity of women's ice hockey in North America, players continue to face limitations because of the prohibition of body checking. In this paper, we argue from a liberal feminist philosophical perspective that this prohibition reinforces existing traditional stereotypes of female athletes. Because the women's game does not…

  19. 12 CFR Appendix A to Part 229 - Routing Number Guide to Next-Day Availability Checks and Local Checks

    Science.gov (United States)

    2010-01-01

    ... Checks and Local Checks A Appendix A to Part 229 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS... Association. The routing number takes two forms: a fractional form and a nine-digit form. A paying bank...

  20. Type Checking with XML Schema in XACT

    DEFF Research Database (Denmark)

    Kirkegaard, Christian; Møller, Anders

    ACT is an extension of Java for making type-safe XML transformations. Unlike other approaches, XACT provides a programming model based on XML templates and XPath together with a type checker based on data-flow analysis. We show how to extend the data-flow analysis technique used in the XACT system...... to support XML Schema as type formalism. The technique is able to model advanced features, such as type derivations and overloaded local element declarations, and also datatypes of attribute values and character data. Moreover, we introduce optional type annotations to improve modularity of the type checking....... The resulting system supports a flexible style of programming XML transformations and provides static guarantees of validity of the generated XML data....

  1. DEPUTY: analysing architectural structures and checking style

    International Nuclear Information System (INIS)

    Gorshkov, D.; Kochelev, S.; Kotegov, S.; Pavlov, I.; Pravilnikov, V.; Wellisch, J.P.

    2001-01-01

    The DepUty (dependencies utility) can be classified as a project and process management tool. The main goal of DepUty is to assist by means of source code analysis and graphical representation using UML, in understanding dependencies of sub-systems and packages in CMS Object Oriented software, to understand architectural structure, and to schedule code release in modularised integration. It also allows a new-comer to more easily understand the global structure of CMS software, and to void circular dependencies up-front or re-factor the code, in case it was already too close to the edge of non-maintainability. The authors will discuss the various views DepUty provides to analyse package dependencies, and illustrate both the metrics and style checking facilities it provides

  2. Static Checking of Interrupt-driven Software

    DEFF Research Database (Denmark)

    Brylow, Dennis; Damgaard, Niels; Palsberg, Jens

    2001-01-01

    Resource-constrained devices are becoming ubiquitous. Examples include cell phones, palm pilots, and digital thermostats. It can be difficult to fit required functionality into such a device without sacrificing the simplicity and clarity of the software. Increasingly complex embedded systems...... require extensive brute-force testing, making development and maintenance costly. This is particularly true for system components that are written in assembly language. Static checking has the potential of alleviating these problems, but until now there has been little tool support for programming...... at the assembly level. In this paper we present the design and implementation of a static checker for interrupt-driven Z86-based software with hard real-time requirements. For six commercial microcontrollers, our checker has produced upper bounds on interrupt latencies and stack sizes, as well as verified...

  3. Model Checking JAVA Programs Using Java Pathfinder

    Science.gov (United States)

    Havelund, Klaus; Pressburger, Thomas

    2000-01-01

    This paper describes a translator called JAVA PATHFINDER from JAVA to PROMELA, the "programming language" of the SPIN model checker. The purpose is to establish a framework for verification and debugging of JAVA programs based on model checking. This work should be seen in a broader attempt to make formal methods applicable "in the loop" of programming within NASA's areas such as space, aviation, and robotics. Our main goal is to create automated formal methods such that programmers themselves can apply these in their daily work (in the loop) without the need for specialists to manually reformulate a program into a different notation in order to analyze the program. This work is a continuation of an effort to formally verify, using SPIN, a multi-threaded operating system programmed in Lisp for the Deep-Space 1 spacecraft, and of previous work in applying existing model checkers and theorem provers to real applications.

  4. Advanced techniques for efficient data integrity checking

    DEFF Research Database (Denmark)

    Martinenghi, Davide

    Integrity constraint checking, understood as the verification of data correctness and well-formedness conditions that must be satisfied in any state of a database, is not fully supported by current database technology. In a typical scenario, a database is required to comply with given semantic...... criteria (the integrity constraints) and to maintain the compliance each time data are updated. Since the introduction of the SQL2 standard, the SQL language started supporting assertions, which allow one to define general data consistency requirements expressing arbitrarily complex “business rules......” that may go beyond predefined constraints such as primary keys and foreign keys. General integrity constraints are, however, far from being widely available in commercial systems; in fact, their usage is commonly not encouraged, since the database management system would not be able to provide...

  5. Statistical Model Checking for Product Lines

    DEFF Research Database (Denmark)

    ter Beek, Maurice H.; Legay, Axel; Lluch Lafuente, Alberto

    2016-01-01

    We report on the suitability of statistical model checking for the analysis of quantitative properties of product line models by an extended treatment of earlier work by the authors. The type of analysis that can be performed includes the likelihood of specific product behaviour, the expected...... average cost of products (in terms of the attributes of the products’ features) and the probability of features to be (un)installed at runtime. The product lines must be modelled in QFLan, which extends the probabilistic feature-oriented language PFLan with novel quantitative constraints among features...... behaviour converge in a discrete-time Markov chain semantics, enabling the analysis of quantitative properties. Technically, a Maude implementation of QFLan, integrated with Microsoft’s SMT constraint solver Z3, is combined with the distributed statistical model checker MultiVeStA, developed by one...

  6. [Infection prevention check-in and infection prevention check-out to prevent nosocomial infections].

    Science.gov (United States)

    Kramer, A; Schilling, M; Heidecke, C D

    2010-02-01

    A precondition for the success of the prevention of SSI is the complete realisation of the proven anti-infective measures in form of the multi-barrier strategy or the so-called bundles. In daily practice it is important to follow the fixed instructions, i. e., to ensure a high compliance. In much the same way as an airline pilot or co-pilot must examine whether all instruments are functioning before each take-off, a comparable procedure should be developed as a pre-operative control for the observance of all -defined measures by the responsible surgeon and for the post-operative supervision by the patient. For the control of the observance of the defined pre-operative prevention measures, a check list with 12 items was developed, named the "infection prevention check-in". The check list is authorised by the responsible surgeon be-fore each operation. For the surveillance of the general hygiene in the post-operative period the "infection prevention check-out" with 14 items was developed. Thereby the patient is able to evaluate the staff's compliance with the hygienic measures at the time of dismissal. With the introduction of the check-lists a simple means is given to involve both the team of the surgeons and the ward staff, together with the patient, into the infection prophylaxis even more effectively. In order to assess the success of those measures, the influence on the rate of SSI is to be determined prospectively. Georg Thieme Verlag Stuttgart, New York.

  7. Do alcohol compliance checks decrease underage sales at neighboring establishments?

    Science.gov (United States)

    Erickson, Darin J; Smolenski, Derek J; Toomey, Traci L; Carlin, Bradley P; Wagenaar, Alexander C

    2013-11-01

    Underage alcohol compliance checks conducted by law enforcement agencies can reduce the likelihood of illegal alcohol sales at checked alcohol establishments, and theory suggests that an alcohol establishment that is checked may warn nearby establishments that compliance checks are being conducted in the area. In this study, we examined whether the effects of compliance checks diffuse to neighboring establishments. We used data from the Complying with the Minimum Drinking Age trial, which included more than 2,000 compliance checks conducted at more than 900 alcohol establishments. The primary outcome was the sale of alcohol to a pseudo-underage buyer without the need for age identification. A multilevel logistic regression was used to model the effect of a compliance check at each establishment as well as the effect of compliance checks at neighboring establishments within 500 m (stratified into four equal-radius concentric rings), after buyer, license, establishment, and community-level variables were controlled for. We observed a decrease in the likelihood of establishments selling alcohol to underage youth after they had been checked by law enforcement, but these effects quickly decayed over time. Establishments that had a close neighbor (within 125 m) checked in the past 90 days were also less likely to sell alcohol to young-appearing buyers. The spatial effect of compliance checks on other establishments decayed rapidly with increasing distance. Results confirm the hypothesis that the effects of police compliance checks do spill over to neighboring establishments. These findings have implications for the development of an optimal schedule of police compliance checks.

  8. Firm Deadline Checking of Safety-Critical Java Applications with Statistical Model Checking

    DEFF Research Database (Denmark)

    Ravn, Anders P.; Thomsen, Bent; Søe Luckow, Kasper

    2017-01-01

    In cyber-physical applications many programs have hard real-time constraints that have to be stringently validated. In some applications, there are programs that have hard deadlines, which must not be violated. Other programs have soft deadlines where the value of the response decreases when...... hard deadline constraints to the case of firm deadlines for application programs written in Safety-Critical Java (SCJ). The existing approach uses models and model checking with the Uppaal toolset; the extension uses the statistical model checking features of Uppaal-smc to provide a hold on firm...... deadlines and performance in the case of soft deadlines. The extended approach is illustrated with examples from applications....

  9. Marketers approve check-off plan

    Energy Technology Data Exchange (ETDEWEB)

    Mantho, M.

    1996-02-01

    For the last several years, we have ended the year with a questionnaire looking into the future. Our panel was asked what was the greatest threat to our industry. Consistently, they have answered {open_quotes}the lack of real growth.{close_quotes} This year was no exception, but this time there was a feeling that something could and would be done. Almost every marketer (98%) said he or she supported the check-off program that would raise considerable funds for public relations and research. This idea isn`t new; it has been discussed year after year. Always the stumbling block was how to raise funds so that each company contributed and no one had a free ride. Last year, it was proposed that a commission created by federal law, be established to oversee funds for the education of consumers and government and provide technology research. If Congress authorizes this plan and members of the industry endorse it, we would have a strong program in place by 1997.

  10. Practitioner perspectives of implementing check & connect.

    Science.gov (United States)

    Hartwig, Elizabeth Kjellstrand; Maynard, Brandy R

    2015-01-01

    While there is a growing reserve of evidence-based practices (EBPs) available to practitioners, much can be learned about how to implement EBPs in real-world settings. Evidence of the effects of a widely disseminated student engagement intervention, Check & Connect (C&C), is emerging yet little is known about the implementation of C&C in community-based settings. The purpose of the authors in this study was to examine practitioner attitudes and perspectives related to the C&C intervention and implementation to gain an understanding of core implementation components that facilitated or impeded implementation. A researcher-developed survey instrument was used to assess practitioner attitudes related to the C&C model and implementation among 14 school-based practitioners working in a dropout prevention program. Findings indicate that practitioners were highly positive about the C&C intervention and in their attitudes about implementing EBPs. Benefits of C&C identified by practitioners included increased relationship building with students, tracking students on a consistent and timely basis, and addressing attendance issues as a main focus of treatment. The most common implementation challenges were time constraints, paperwork, and targeting absentee students. These findings contribute to the emerging literature on C&C and the implementation of EBPs in schools and community-based settings.

  11. Effective ambiguity checking in biosequence analysis

    Directory of Open Access Journals (Sweden)

    Giegerich Robert

    2005-06-01

    Full Text Available Abstract Background Ambiguity is a problem in biosequence analysis that arises in various analysis tasks solved via dynamic programming, and in particular, in the modeling of families of RNA secondary structures with stochastic context free grammars. Several types of analysis are invalidated by the presence of ambiguity. As this problem inherits undecidability (as we show here from the namely problem for context free languages, there is no complete algorithmic solution to the problem of ambiguity checking. Results We explain frequently observed sources of ambiguity, and show how to avoid them. We suggest four testing procedures that may help to detect ambiguity when present, including a just-in-time test that permits to work safely with a potentially ambiguous grammar. We introduce, for the special case of stochastic context free grammars and RNA structure modeling, an automated partial procedure for proving non-ambiguity. It is used to demonstrate non-ambiguity for several relevant grammars. Conclusion Our mechanical proof procedure and our testing methods provide a powerful arsenal of methods to ensure non-ambiguity.

  12. Model checking in multiple imputation: an overview and case study

    Directory of Open Access Journals (Sweden)

    Cattram D. Nguyen

    2017-08-01

    Full Text Available Abstract Background Multiple imputation has become very popular as a general-purpose method for handling missing data. The validity of multiple-imputation-based analyses relies on the use of an appropriate model to impute the missing values. Despite the widespread use of multiple imputation, there are few guidelines available for checking imputation models. Analysis In this paper, we provide an overview of currently available methods for checking imputation models. These include graphical checks and numerical summaries, as well as simulation-based methods such as posterior predictive checking. These model checking techniques are illustrated using an analysis affected by missing data from the Longitudinal Study of Australian Children. Conclusions As multiple imputation becomes further established as a standard approach for handling missing data, it will become increasingly important that researchers employ appropriate model checking approaches to ensure that reliable results are obtained when using this method.

  13. Model checking in multiple imputation: an overview and case study.

    Science.gov (United States)

    Nguyen, Cattram D; Carlin, John B; Lee, Katherine J

    2017-01-01

    Multiple imputation has become very popular as a general-purpose method for handling missing data. The validity of multiple-imputation-based analyses relies on the use of an appropriate model to impute the missing values. Despite the widespread use of multiple imputation, there are few guidelines available for checking imputation models. In this paper, we provide an overview of currently available methods for checking imputation models. These include graphical checks and numerical summaries, as well as simulation-based methods such as posterior predictive checking. These model checking techniques are illustrated using an analysis affected by missing data from the Longitudinal Study of Australian Children. As multiple imputation becomes further established as a standard approach for handling missing data, it will become increasingly important that researchers employ appropriate model checking approaches to ensure that reliable results are obtained when using this method.

  14. Body checking in the eating disorders: association with narcissistic characteristics.

    Science.gov (United States)

    Waller, Glenn; Sines, Jennie; Meyer, Caroline; Mountford, Victoria

    2008-04-01

    There is substantial evidence that body image is a clinically important element of eating pathology, and that patients' body checking cognitions and behaviours are key elements in the maintenance of that body image. However, there is little understanding of individual differences in body checking. This study considered the potential role of narcissism and narcissistic defences in driving body checking cognitions and behaviours. 68 eating-disordered and 70 non-clinical women completed well-validated measures of body checking and narcissism. There were specific patterns of association between different elements of narcissism and different aspects of body checking. These patterns are compatible with a model where body checking serves the defensive function of maintaining self-esteem, rather than promoting positive levels of narcissistic self-esteem.

  15. Nucleus accumbens core and pathogenesis of compulsive checking

    Science.gov (United States)

    Ballester González, Javier; Dvorkin-Gheva, Anna; Silva, Charmaine; Foster, Jane A.

    2015-01-01

    To investigate the role of the nucleus accumbens core (NAc) in the development of quinpirole-induced compulsive checking, rats received an excitotoxic lesion of NAc or sham lesion and were injected with quinpirole (0.5 mg/kg) or saline; development of checking behavior was monitored for 10 biweekly tests. The results showed that even after the NAc lesion, quinpirole still induced compulsive checking, suggesting that the pathogenic effects produced by quinpirole lie outside the NAc. Although the NAc lesion did not prevent the induction of compulsive checking, it altered how quickly it develops, suggesting that the NAc normally contributes toward the induction of compulsive checking. Saline-treated rats with an NAc lesion were hyperactive, but did not develop compulsive checking, indicating that hyperactivity by itself is not sufficient for the pathogenesis of compulsive checking. It is proposed that compulsive checking is the exaggerated output of a security motivation system and that the NAc serves as a neural hub for coordinating the orderly activity of neural modules of this motivational system. Evidence is considered suggesting that the neurobiological condition for the pathogenesis of compulsive checking is two-fold: activation of dopamine D2/D3 receptors without concurrent stimulation of D1-like receptors and long-term plastic changes related to quinpirole-induced sensitization. PMID:25426580

  16. Mothers' use of and attitudes to BabyCheck.

    OpenAIRE

    Thomson, Hilary; Ross, Sue; Wilson, Philip; McConnachie, Alex; Watson, Richard

    2002-01-01

    A copy of BabyCheck was sent to 497 mothers shortly after the birth of their baby. Six months later they were sent a questionnaire asking about their use of and attitudes to, BabyCheck. Questionnaires were returned by 323 (65%) mothers; 215 (67%) of them reported reading BabyCheck, the majority found it easy to understand (74%) and agreed with the advice (67%). Eighty-four (26%) of the mothers who returned the questionnaires reported using BabyCheck when their baby was ill; of these, 71% agre...

  17. Cycle time reduction by Html report in mask checking flow

    Science.gov (United States)

    Chen, Jian-Cheng; Lu, Min-Ying; Fang, Xiang; Shen, Ming-Feng; Ma, Shou-Yuan; Yang, Chuen-Huei; Tsai, Joe; Lee, Rachel; Deng, Erwin; Lin, Ling-Chieh; Liao, Hung-Yueh; Tsai, Jenny; Bowhill, Amanda; Vu, Hien; Russell, Gordon

    2017-07-01

    The Mask Data Correctness Check (MDCC) is a reticle-level, multi-layer DRC-like check evolved from mask rule check (MRC). The MDCC uses extended job deck (EJB) to achieve mask composition and to perform a detailed check for positioning and integrity of each component of the reticle. Different design patterns on the mask will be mapped to different layers. Therefore, users may be able to review the whole reticle and check the interactions between different designs before the final mask pattern file is available. However, many types of MDCC check results, such as errors from overlapping patterns usually have very large and complex-shaped highlighted areas covering the boundary of the design. Users have to load the result OASIS file and overlap it to the original database that was assembled in MDCC process on a layout viewer, then search for the details of the check results. We introduce a quick result-reviewing method based on an html format report generated by Calibre® RVE. In the report generation process, we analyze and extract the essential part of result OASIS file to a result database (RDB) file by standard verification rule format (SVRF) commands. Calibre® RVE automatically loads the assembled reticle pattern and generates screen shots of these check results. All the processes are automatically triggered just after the MDCC process finishes. Users just have to open the html report to get the information they need: for example, check summary, captured images of results and their coordinates.

  18. Antibodies Against Melanin

    African Journals Online (AJOL)

    1973-01-06

    Jan 6, 1973 ... Departments of Internal Medicine and Anatomical Pathology, University of Stellenbosch and MRC. Pigment Metabolism Research Unit, ... at the production of antibodies against natural melanoprotein. and a consideration of our negative .... the random polymerization of several monomers, antibody formed ...

  19. Recombinant renewable polyclonal antibodies.

    Science.gov (United States)

    Ferrara, Fortunato; D'Angelo, Sara; Gaiotto, Tiziano; Naranjo, Leslie; Tian, Hongzhao; Gräslund, Susanne; Dobrovetsky, Elena; Hraber, Peter; Lund-Johansen, Fridtjof; Saragozza, Silvia; Sblattero, Daniele; Kiss, Csaba; Bradbury, Andrew R M

    2015-01-01

    Only a small fraction of the antibodies in a traditional polyclonal antibody mixture recognize the target of interest, frequently resulting in undesirable polyreactivity. Here, we show that high-quality recombinant polyclonals, in which hundreds of different antibodies are all directed toward a target of interest, can be easily generated in vitro by combining phage and yeast display. We show that, unlike traditional polyclonals, which are limited resources, recombinant polyclonal antibodies can be amplified over one hundred million-fold without losing representation or functionality. Our protocol was tested on 9 different targets to demonstrate how the strategy allows the selective amplification of antibodies directed toward desirable target specific epitopes, such as those found in one protein but not a closely related one, and the elimination of antibodies recognizing common epitopes, without significant loss of diversity. These recombinant renewable polyclonal antibodies are usable in different assays, and can be generated in high throughput. This approach could potentially be used to develop highly specific recombinant renewable antibodies against all human gene products.

  20. Antibody engineering: methods and protocols

    National Research Council Canada - National Science Library

    Chames, Patrick

    2012-01-01

    "Antibody Engineering: Methods and Protocols, Second Edition was compiled to give complete and easy access to a variety of antibody engineering techniques, starting from the creation of antibody repertoires and efficient...

  1. Anti-insulin antibody test

    Science.gov (United States)

    Insulin antibodies - serum; Insulin Ab test; Insulin resistance - insulin antibodies; Diabetes - insulin antibodies ... You appear to have an allergic response to insulin Insulin no longer seems to control your diabetes

  2. 25 CFR 115.704 - May we accept for deposit into a trust account retirement checks/payments or pension fund checks...

    Science.gov (United States)

    2010-04-01

    ... checks/payments or pension fund checks/payments even though those funds are not specified in § 115.702... May we accept for deposit into a trust account retirement checks/payments or pension fund checks.../payments or pension fund checks/payments or any funds from sources that are not identified in the table in...

  3. 16 CFR 240.12 - Checking customer's use of payments.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Checking customer's use of payments. 240.12 Section 240.12 Commercial Practices FEDERAL TRADE COMMISSION GUIDES AND TRADE PRACTICE RULES GUIDES FOR ADVERTISING ALLOWANCES AND OTHER MERCHANDISING PAYMENTS AND SERVICES § 240.12 Checking customer's use of...

  4. Posterior Predictive Model Checking for Multidimensionality in Item Response Theory

    Science.gov (United States)

    Levy, Roy; Mislevy, Robert J.; Sinharay, Sandip

    2009-01-01

    If data exhibit multidimensionality, key conditional independence assumptions of unidimensional models do not hold. The current work pursues posterior predictive model checking, a flexible family of model-checking procedures, as a tool for criticizing models due to unaccounted for dimensions in the context of item response theory. Factors…

  5. Simple nonparametric checks for model data fit in CAT

    NARCIS (Netherlands)

    Meijer, R.R.

    2005-01-01

    In this paper, the usefulness of several nonparametric checks is discussed in a computerized adaptive testing (CAT) context. Although there is no tradition of nonparametric scalability in CAT, it can be argued that scalability checks can be useful to investigate, for example, the quality of item

  6. Check & Connect. What Works Clearinghouse Intervention Report. Updated May 2015

    Science.gov (United States)

    What Works Clearinghouse, 2015

    2015-01-01

    "Check & Connect" aims to help students stay in school by continually monitoring school performance and providing individualized attention through mentoring, case management, and other supports. In 2006, the WWC published a systematic review of all the studies that examined the impact of "Check & Connect" on high school…

  7. Check-up Measurement (update). Deliverable D5.22

    NARCIS (Netherlands)

    Holtzer, A.C.G.; Giessen, A.M.D. van der; Djurica, M.

    2015-01-01

    This deliverable D5.22 presents the GEN6 check-up measurement. It describes the most prominent outcomes of the GEN6 project up to this point in time. The check-up measurement helps to focus the monitoring towards the most relevant achievements of the project, such that an efficient and well-targeted

  8. 31 CFR 10.31 - Negotiation of taxpayer checks.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Negotiation of taxpayer checks. 10.31 Section 10.31 Money and Finance: Treasury Office of the Secretary of the Treasury PRACTICE BEFORE THE... § 10.31 Negotiation of taxpayer checks. A practitioner who prepares tax returns may not endorse or...

  9. Modern Trends in Airport Self Check-in Kiosks

    Directory of Open Access Journals (Sweden)

    Jarmila Sabatová

    2016-10-01

    Full Text Available Due to maintain the flow of the check-in process of air passengers, it is essential that services that ensure this process have been carried as quickly and effectively. One of the major current problems in this area is the efficiency of clearance of a large number of passengers over the check-in counters. By the gradual development of so-called self check-in services eventually delegate some activities in check-in process to passengers and the entire clearance process to speed up. In this article the authors deal with current state of the use of self check-in services in the world and predict the expected evolution of these services in the future. Subsequently, the authors present a new design of self-service kiosk and graphical user interface (GUI of application such self-service check-in kiosk based on the analysis of the functions and features of similar solutions available on the market and with considering all currently known IATA requirements and the criteria relating to disabled passengers in order to lighten the load check-in counters and thereby accelerated the clearance of the passenger at the airport. The aim of the authors was to create a cost competitive solution offering such new features and services that do not offer other solutions, with an emphasis on improving the efficiency of the check-in process of passengers at the airport.

  10. Partial-Order Reduction for GPU Model Checking

    NARCIS (Netherlands)

    Neele, T.; Wijs, A.; Bosnacki, D.; van de Pol, Jan Cornelis; Artho, C; Legay, A.; Peled, D.

    2016-01-01

    Model checking using GPUs has seen increased popularity over the last years. Because GPUs have a limited amount of memory, only small to medium-sized systems can be verified. For on-the-fly explicit-state model checking, we improve memory efficiency by applying partial-order reduction. We propose

  11. Checking Consistency of Pedigree Information is NP-complete

    DEFF Research Database (Denmark)

    Aceto, Luca; Hansen, Jens A.; Ingolfsdottir, Anna

    Consistency checking is a fundamental computational problem in genetics. Given a pedigree and information on the genotypes of some of the individuals in it, the aim of consistency checking is to determine whether these data are consistent with the classic Mendelian laws of inheritance. This probl...

  12. Fraud by using a check | Azarian | Journal of Fundamental and ...

    African Journals Online (AJOL)

    If someone used check as a tool to fraud and looting of property of others, should they just be subject to check law, and according to the provisions of the law are prosecuted? Are crook people the same as honorable merchants that due to some unwanted changes and fluctuations in the market and social conditions

  13. Monoclonal antibody "gold rush".

    Science.gov (United States)

    Maggon, Krishan

    2007-01-01

    The market, sales and regulatory approval of new human medicines, during the past few years, indicates increasing number and share of new biologics and emergence of new multibillion dollar molecules. The global sale of monoclonal antibodies in 2006 were $20.6 billion. Remicade had annual sales gain of $1 billion during the past 3 years and five brands had similar increase in 2006. Rituxan with 2006 sales of $4.7 billion was the best selling monoclonal antibody and biological product and the 6th among the top selling medicinal brand. It may be the first biologic and monoclonal antibody to reach $10 billion annual sales in the near future. The strong demand from cancer and arthritis patients has surpassed almost all commercial market research reports and sales forecast. Seven monoclonal antibody brands in 2006 had sales exceeding $1 billion. Humanized or fully human monoclonal antibodies with low immunogenicity, enhanced antigen binding and reduced cellular toxicity provide better clinical efficacy. The higher technical and clinical success rate, overcoming of technical hurdles in large scale manufacturing, low cost of market entry and IND filing, use of fully human and humanized monoclonal antibodies has attracted funds and resources towards R&D. Review of industry research pipeline and sales data during the past 3 years indicate a real paradigm shift in industrial R&D from pharmaceutical to biologics and monoclonal antibodies. The antibody bandwagon has been joined by 200 companies with hundreds of new projects and targets and has attracted billions of dollars in R&D investment, acquisitions and licensing deals leading to the current Monoclonal Antibody Gold Rush.

  14. Antibody affinity maturation

    DEFF Research Database (Denmark)

    Skjødt, Mette Louise

    surface expression of various antibody formats in the generated knockout strain. Functional scFv and scFab fragments were efficiently displayed on yeast whereas impaired chain assembly and heavy chain degradation was observed for display of full-length IgG molecules. To identify the optimal polypeptide......-antibody interface and the antibody intraface.the microenvironment and ecology of Acaryochloris and Prochloron, and in this thesis we attempted to further describe the distribution, growth characteristics and adaptive/regulatory mechanisms of these two cyanobacteria, both in their natural habitat and under defined...

  15. Using a Changing-Criterion Design to Evaluate the Effects of Check-In/Check-Out with Goal Modification

    Science.gov (United States)

    McDaniel, Sara C.; Bruhn, Allison L.

    2016-01-01

    Check-in/check-out (CICO) is a Tier 2 behavioral intervention that has demonstrated effectiveness for students with challenging behavior in a variety of educational settings. Existing research has focused primarily on testing the intervention's effectiveness and the role of behavioral function in moderating response to intervention. Only a handful…

  16. Serum herpes simplex antibodies

    Science.gov (United States)

    ... causes cold sores (oral herpes). HSV-2 causes genital herpes. How the Test is Performed A blood sample ... person has ever been infected with oral or genital herpes . It looks for antibodies to herpes simplex virus ...

  17. Anti-sulfotyrosine antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Bertozzi, Carolyn R [Berkeley, CA; Kehoe, John [Saint Davids, PA; Bradbury, Andrew M [Santa Fe, NM

    2009-09-15

    The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin.

  18. Bifunctional antibodies for radioimmunotherapy.

    Science.gov (United States)

    Chatal, J F; Faivre-Chauvet, A; Bardies, M; Peltier, P; Gautherot, E; Barbet, J

    1995-04-01

    In two-step targeting technique using bifunctional antibodies, a nonradiolabeled immunoconjugate with slow uptake kinetics (several days) is initially injected, followed by a small radiolabeled hapten with fast kinetics (several hours) that binds to the bispecific immunoconjugate already taken up by the tumor target. In patients with colorectal or medullary thyroid cancer, clinical studies performed with an anti-CEA/anti-DTPA-indium bifunctional antibody and an indium-111-labeled di-DTPA-TL bivalent hapten showed that tumor uptake was not modified compared to results for F(ab')2 fragments of the same anti-CEA antibody directly labeled with indium-111, whereas the radioactivity of normal tissues was significantly reduced (3- to 6-fold). The fast tumor uptake kinetics (several hours) and high or very high tumor-to-normal tissue ratios obtained with the bifunctional antibody technique are favorable parameters for efficient radioimmunotherapy.

  19. Antibody Blood Tests

    Science.gov (United States)

    Antibody Blood Tests Researchers have discovered that people with celiac disease who eat gluten have higher than normal levels of ... do I do if I have a negative blood test (or panel) but I’m still having symptoms? ...

  20. Development of radiolabelling techniques of anti-CEA monoclonal antibody

    International Nuclear Information System (INIS)

    Castiglia, S.G. de

    1998-01-01

    The purpose of this work was to label monoclonal and polyclonal antibodies with 99 Tc m such as the ior-CEA-1 antibody and polyclonal IgG using a direct method, to check the radiochemical and biological behavior of labelled products, to prepare it under sterile and apyrogenic conditions as a lyophilized kit and to employ it in clinical trials. In addition, a photoactivation method was used to label polyclonal IgG with 99 Tc m and to compare with the established method using mercaptoethanol (2-ME) as the reducing agent. Finally polyclonal IgG was labelled using an indirect method in which a chelator was covalently attached to the protein and the 99 Tc m added as glucoheptonate complex. The properties of 99 Tc m when labelled with monoclonal and polyclonal antibodies by different methods were assessed by in vitro and in vivo studies

  1. Improvement of seawater booster pump outlet check valve

    International Nuclear Information System (INIS)

    Li Xuning; Du Yansong; Huang Huimin

    2010-01-01

    Conventional island seawater booster pump set of QNPC 310 MWe unit are very important in the whole circulating cooling system, and the integrate function of seawater booster pump outlet check valve is the foundation of steady operation of the seawater booster pump set. The article mainly introduce that through the analyses to the reason to the problem that the seawater booster pump outlet check valve of QNPC 310 MWe unit appeared in past years by our team, and considering the influence of operation condition and circumstance, the team improve the seawater booster pump outlet check valve from swing check valve to shuttle check valve which operate more appropriately in the system. By the test of continuous practice, we make further modification to the inner structure of shuttle check valve contrapuntally, and therefore we solve the problem in seawater booster pump outlet check valve fundamentally which has troubled the security of system operation in past years, so we realize the aim of technical improvement and ensure that the system operate in safety and stability. (authors)

  2. Check valve diagnostics utilizing acoustic and magnetic technologies

    International Nuclear Information System (INIS)

    Agostinelli, A.

    1991-01-01

    The potential hazards associated with check valve failures make it necessary to detect check valve problems before they cause significant damage. In the nuclear industry, check valve failures are known to have resulted in damaging water hammer conditions, overpressurization of low pressure systems, steam binding of auxiliary feedwater pumps, and other serious component damage in power plant environments. Similar problems exist in fossil power and various process industries, but the resources dedicated to valve maintenance issues are greatly reduced. However, the trend toward plant life extension, predictive maintenance, and maximum operating efficiency will raise the general awareness of check valve maintenance in commercial (non-nuclear) applications. Although this paper includes specific references to the nuclear industry, the check valve problem conditions and diagnostic techniques apply across all power and process plant environments. The ability to accurately diagnose check valve conditions using non-intrusive, predictive maintenance testing methods allows for a more cost-efficient, productive maintenance program. One particular diagnostic system, called Quickcheck trademark, assists utilities in addressing these concerns. This article presents actual field test data and analysis that demonstrate the power of check valve diagnostics. Prior to presenting the field data, a brief overview of the system is overviewed

  3. Check dam and polyacrylamide performance under simulated stormwater runoff.

    Science.gov (United States)

    Kang, Jihoon; McCaleb, Melanie M; McLaughlin, Richard A

    2013-11-15

    High levels of turbidity and fine suspended sediments are often found in stormwater discharges from construction sites even when best management practices (BMPs) for sediment control are in place. This study evaluated turbidity reduction by three check dam types: 1) rock check dam representing a standard BMP, 2) excelsior wattle representing a fiber check dam (FCD), and 3) rock check dam wrapped with excelsior erosion control blanket (rock + excelsior ECB) representing an alternative FCD. Three check dams (all same type) were installed in a lined, 24-m ditch on a 5-7% slope and three consecutive simulated stormwater flows were run in the ditch. Additional tests were performed by adding granular polyacrylamide (PAM) on the check dams in the same manner using two sediment sources differing in clay content. Without PAM treatment, significantly higher effluent turbidity (>900 nephelometric turbidity units (NTU)) exited the ditch with rock check dams than with excelsior wattles or rock + excelsior ECBs (dam types was in the order of excelsior wattle > rock + excelsior ECB > rock check dam, indicating better water pooling behind the wattle. The PAM treatment reduced turbidity substantially (>75% relative to no PAM treatment) for all check dam types and it was very effective in excelsior wattles (<57 NTU) and rock + excelsior ECBs (<90 NTU) even during the third storm event. This study demonstrates that the passive treatment of runoff with PAM on FCDs (or rock + excelsior ECB) in construction site ditches can be very effective for sediment retention and turbidity reduction. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. PREREQUISITE PROGRAMMES IN OWN CHECKS IN STATUTORY AND VOLUNTARY LEGISLATION

    Directory of Open Access Journals (Sweden)

    E. Guidi

    2012-08-01

    Full Text Available Prerequisite Programmes approach is a requirement for implementing a correct own check plan. This new approach, born according to the European Legislation, is completely recognized by third Nation Authorities and private Inspection and Accreditation Bodies. This method is the basis to verify if an own check system is under control and to verify if corrective actions are built up to warrant hygienic production standards. The present work demonstrate that a correct own check plan is built up only by a Pre Requisites Program approach. The new UNI EN ISO 22000:2005 standard describe this concept specifying the difference between PRP and CCP.

  5. Member checking and Heideggerian phenomenology: a redundant component.

    Science.gov (United States)

    McConnell-Henry, Tracy; Chapman, Ysanne; Francis, Karen

    2011-01-01

    Although member-checking has long been accepted as the gold standard in quantitative research, it is not the pinnacle for expressing rigour in Heideggerian phenomenology because it contradicts many o the underpinning philosophies. Similarly, employing 'experts' to confirm findings conflicts with the values of interpretivism. In this paper, th authors argue that member-checking is frequently used to cover poor interview technique or a lack of understanding of the methodology chosen to underpin the study. They debate why member-checking is incongruent with Heideggerian philosophy and suggest strategies that enhance the generation of data and render the follow-u interview redundant.

  6. Schedulability of Herschel revisited using statistical model checking

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Legay, Axel

    2015-01-01

    to obtain some guarantee on the (un)schedulability of the model even in the presence of undecidability. Two methods are considered: symbolic model checking and statistical model checking. Since the model uses stop-watches, the reachability problem becomes undecidable so we are using an over......-approximation technique. We can safely conclude that the system is schedulable for varying values of BCET. For the cases where deadlines are violated, we use polyhedra to try to confirm the witnesses. Our alternative method to confirm non-schedulability uses statistical model-checking (SMC) to generate counter...

  7. Implementing Model-Check for Employee and Management Satisfaction

    Science.gov (United States)

    Jones, Corey; LaPha, Steven

    2013-01-01

    This presentation will discuss methods to which ModelCheck can be implemented to not only improve model quality, but also satisfy both employees and management through different sets of quality checks. This approach allows a standard set of modeling practices to be upheld throughout a company, with minimal interaction required by the end user. The presenter will demonstrate how to create multiple ModelCheck standards, preventing users from evading the system, and how it can improve the quality of drawings and models.

  8. Natural and Man-made Antibody Repertories for Antibody Discovery

    Directory of Open Access Journals (Sweden)

    Juan C eAlmagro

    2012-11-01

    Full Text Available Antibodies are the fastest-growing segment of the biologics market. The success of antibody-based drugs resides in their exquisite specificity, high potency, stability, solubility, safety and relatively inexpensive manufacturing process in comparison with other biologics. We outline here the structural studies and fundamental principles that define how antibodies interact with diverse targets. We also describe the antibody repertoires and affinity maturation mechanisms of human, mice and chickens, plus the use of novel single-domain antibodies in camelids and sharks. These species all utilize diverse evolutionary solutions to generate specific and high affinity antibodies and illustrate the plasticity of natural antibody repertoires. In addition, we discuss the multiple variations of man-made antibody repertoires designed and validated in the last two decades, which have served as tools to explore how the size, diversity and composition of a repertoire impact the antibody discovery process.

  9. Model Checking Timed Automata with Priorities using DBM Subtraction

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Pettersson, Paul

    2006-01-01

    In this paper we describe an extension of timed automata with priorities, and efficient algorithms to compute subtraction on DBMs (difference bounded matrices), needed in symbolic model-checking of timed automata with priorities. The subtraction is one of the few operations on DBMs that result in...... this number affects the performance of symbolic model-checking. The uses of the DBM subtraction operation extend beyond timed automata with priorities. It is also useful for allowing guards on transitions with urgent actions, deadlock checking, and timed games.......In this paper we describe an extension of timed automata with priorities, and efficient algorithms to compute subtraction on DBMs (difference bounded matrices), needed in symbolic model-checking of timed automata with priorities. The subtraction is one of the few operations on DBMs that result...

  10. Automatic checking system of radioactivity in motor-cars 'AKKORD'

    International Nuclear Information System (INIS)

    Kuechler, L.; Seidler, M.; Zierenberg, B.

    1994-01-01

    A monitoring device has been developed for an automated checking of all vehicles leaving or entering a nuclear installation against uncontrolled lost of radioactive material. This device is an excellent tool for radioactive material flow control. (orig.) [de

  11. Lessons Learned Model Checking an Industrial Communications Library

    National Research Council Canada - National Science Library

    Ivers, James

    2005-01-01

    Model checking is a fully automated formal verification technology that can be used to determine whether models of software satisfy behavioral requirements in such areas as safety, reliability, and security...

  12. Multi-Valued Modal Fixed Point Logics for Model Checking

    Science.gov (United States)

    Nishizawa, Koki

    In this paper, I will show how multi-valued logics are used for model checking. Model checking is an automatic technique to analyze correctness of hardware and software systems. A model checker is based on a temporal logic or a modal fixed point logic. That is to say, a system to be checked is formalized as a Kripke model, a property to be satisfied by the system is formalized as a temporal formula or a modal formula, and the model checker checks that the Kripke model satisfies the formula. Although most existing model checkers are based on 2-valued logics, recently new attempts have been made to extend the underlying logics of model checkers to multi-valued logics. I will summarize these new results.

  13. Review and analysis of check valve failure data

    International Nuclear Information System (INIS)

    Todd, M.D.; Casada, D.A.

    1992-01-01

    Check valve operating problems in recent years have resulted in significant operating transients, increased cost and decreased system availability. There has been, in response, additional attention given to check valves by utilities, as well as the US Nuclear Regulatory Commission and the American Society of Mechanical Engineers Operation and Maintenance Committee. All these organizations have the fundamental goal of ensuring reliable operation of check valves. A key ingredient to an engineering-oriented reliability improvement effort is a thorough understanding of relevant historical experience. Oak Ridge National Laboratory is currently conducting a detailed review of historical failure data available through the Institute of Nuclear Power Operation's Nuclear Plant Reliability Data System. The focus of the review is on check valve failures that have involved significant degradation of the valve internal parts. A variety of parameters are being considered during the review, including size, age, system of service, method of failure discovery, the affected valve parts, attributed causes, and corrective actions

  14. NRC valve performance test program - check valve testing

    International Nuclear Information System (INIS)

    Jeanmougin, N.M.

    1987-01-01

    The Valve Performance Test Program addresses the current requirements for testing of pressure isolation valves (PIVs) in light water reactors. Leak rate monitoring is the current method used by operating commercial power plants to survey the condition of their PIVs. ETEC testing of three check valves (4-inch, 6-inch, and 12-inch nominal diameters) indicates that leak rate testing is not a reliable method for detecting impending valve failure. Acoustic emission monitoring of check valves shows promise as a method of detecting loosened internals damage. Future efforts will focus on evaluation of acoustic emission monitoring as a technique for determining check valve condition. Three gate valves also will be tested to evaluate whether the check valve results are applicable to gate type PIVs

  15. A Succinct Approach to Static Analysis and Model Checking

    DEFF Research Database (Denmark)

    Filipiuk, Piotr

    In a number of areas software correctness is crucial, therefore it is often desirable to formally verify the presence of various properties or the absence of errors. This thesis presents a framework for concisely expressing static analysis and model checking problems. The framework facilitates...... in the classical formulation of ALFP logic. Finally, we show that the logics and the associated solvers can be used for rapid prototyping. We illustrate that by a variety of case studies from static analysis and model checking....

  16. Progress realized by numerized Eddy current checking-chains

    International Nuclear Information System (INIS)

    Guerin, F.; Blanchet, A.

    1985-01-01

    Until the last ten years , the tubes of the Steam Generators of the Nuclear Stations were inspected by means of Eddy Current with analogical checkings-chains. HBS Company has perfected a numerized checking-chain allowing transmission up to 300 m of the E.C. signals. In a near future, it will be then possible to do periodical inspections of Steam Generators from cabins located out of the reactor building [fr

  17. SOLA-LOOP analysis of a back pressure check valve

    International Nuclear Information System (INIS)

    Travis, J.R.

    1984-01-01

    The SOLA-LOOP computer code for transient, nonequilibrium, two-phase flows in networks has been coupled with a simple valve model to analyze a feedwater pipe breakage with a back-pressure check valve. Three tests from the Superheated Steam Reactor Safety Program Project (PHDR) at Kahl, West Germany, are analyzed, and the calculated transient back-pressure check valve behavior and fluid dynamics effects are found to be in excellent agreement with the experimentally measured data

  18. Dynamic State Space Partitioning for External Memory Model Checking

    DEFF Research Database (Denmark)

    Evangelista, Sami; Kristensen, Lars Michael

    2009-01-01

    We describe a dynamic partitioning scheme usable by model checking techniques that divide the state space into partitions, such as most external memory and distributed model checking algorithms. The goal of the scheme is to reduce the number of transitions that link states belonging to different...... partitions, and thereby limit the amount of disk access and network communication. We report on several experiments made with our verification platform ASAP that implements the dynamic partitioning scheme proposed in this paper....

  19. Checking transfer efficiency and equal loading via qualitative optical way in western blotting.

    Science.gov (United States)

    Gong, Jun-Hua; Gong, Jian-Ping; Zheng, Kai-Wen

    2017-11-01

    The ability to determine that successful transfer and equal loading occur prior to using primary antibodies is important. And total protein staining is commonly used to check transfer efficiency and normalization, which play a crucial role in western blotting. Ponceau S and coomassie blue are commonly used, but there are disadvantages reported in recent years. Therefore, we are interested in finding another method, which is cheap, easy and fast. As we know, protein binding region of PVDF membrane is still hydrophilic when carbinol volatilizes, however, the non-protein binding region of PVDF membrane became hydrophobic again. And this different wettability between non-protein binding region and protein binding region of Polyvinylidene difluoride membrane may be used to check transfer efficiency and equal loading in western blotting. Based on the principle above, we describe an optical approach where an experimenter can observe that the proteins have been transferred to the membrane without any staining within minutes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Assessment of diagnostic methods for determining degradation of check valves

    International Nuclear Information System (INIS)

    Haynes, H.D.; Farmer, W.S.

    1992-01-01

    The Oak Ridge National Laboratory (ORNL) has carried out a comprehensive aging assessment of check valves in support of the Nuclear Plant Aging Research (NPAR) program. This paper provides a summary of the ORNL check valve aging assessment with emphasis on the identification, evaluation, and application of check valve monitoring methods and techniques. Several check valve monitoring methods are described and compared. These methods include: acoustic emission monitoring, ultrasonic inspection, magnetic flux signature analysis (MFSA), external magnetics. These diagnostic technologies were shown to be useful in determining check valve condition (e.g., disc position, disc motion, and seat leakage), although none of the methods was by itself, successful in monitoring all three condition indicators. The combination of acoustic emission with either ultrasonics or one of the magnetic technologies, however, yields a monitoring system that succeeds in providing the sensitivity to detect all major check valve operating conditions. Other areas covered in the paper include descriptions of relevant regulatory issues, utility group activities, and interactions ORNL has had with outside organizations for the purpose of disseminating research results

  1. Student criminal background checks in colleges of allied health.

    Science.gov (United States)

    Wyatt, Diane; Aziz, Hassan; Mahoney, Sherry; Gilman, Frances H

    2008-01-01

    The demand that criminal background checks be performed for students in allied health schools and programs has soared in recent years. The need for criminal background checks on students entering the health care professions has emerged as a critical issue largely due to requirements by clinical affiliate training sites. The Joint Commission published a standard stating, "for staff, students and volunteers who work in the same capacity as staff who provide care, treatment, and services, at Elements of Performance 5 states criminal background checks are verified when required by law and regulation and organization policy." More simply stated, this means that criminal background check records must be verifiable if required by some authoritative entity such as state law. However, whether by misinterpretation of the standard or through conscious decision by organization policy makers, many health care organizations suddenly began to require criminal background checks as part of their affiliation agreements with health related schools or programs. The focus of this study was to identify current practices of allied health institutions regarding their conduct of criminal background checks on students entering the allied health professions.

  2. Antibody informatics for drug discovery

    DEFF Research Database (Denmark)

    Shirai, Hiroki; Prades, Catherine; Vita, Randi

    2014-01-01

    to the antibody science in every project in antibody drug discovery. Recent experimental technologies allow for the rapid generation of large-scale data on antibody sequences, affinity, potency, structures, and biological functions; this should accelerate drug discovery research. Therefore, a robust bioinformatic...... infrastructure for these large data sets has become necessary. In this article, we first identify and discuss the typical obstacles faced during the antibody drug discovery process. We then summarize the current status of three sub-fields of antibody informatics as follows: (i) recent progress in technologies...... for antibody rational design using computational approaches to affinity and stability improvement, as well as ab-initio and homology-based antibody modeling; (ii) resources for antibody sequences, structures, and immune epitopes and open drug discovery resources for development of antibody drugs; and (iii...

  3. Antithyroglobulin Antibodies and Antimicrosomal Antibodies in Various Thyroid Diseases

    International Nuclear Information System (INIS)

    Lee, Gwon Jun; Hong, Key Sak; Choi, Kang Won; Lee, Kyu; Koh, Chang Soon; Lee, Mun Ho; Park, Sung Hoe; Chi, Je Geun; Lee, Sang Kook

    1979-01-01

    The authors investigated the incidence of antithyroglobulin antibodies and antibodies and antimicrosomal antibodies measured by tanned red cell hemagglutination method in subjects suffering from various thyroid disorders. 1) In 15 normal patients, neither suffering from any thyroid diseases nor from any other autoimmune disorders, the antithyroglobulin antibodies were all negative, but the antimicrosomal antibody was positive only in one patient (6.7%). 2) The antithyroglobulin antibodies were positive in 31.5% (34 patients) of 108 patients with various thyroid diseases, and the antimicrosomal antibodies were positive in 37.0% (40 patients). 3) of the 25 patients with Graves' diseases, 7 patients (28.0%) showed positive for the antithyroglobulin antibodies, and 9 (36.0%) for the antimicrosomal antibodies. There was no definite differences in clinical and thyroid functions between the groups with positive and negative results. 4) Both antibodies were positive in 16 (88.9%) and 17 (94.4%) patients respectively among 18 patients with Hashimoto's thyroiditis, all of them were diagnosed histologically. 5) Three out of 33 patients with thyroid adenoma showed positive antibodies, and 3 of 16 patients with thyroid carcinoma revealed positive antibodies. 6) TRCH antibodies demonstrated negative results in 2 patients with subacute thyroiditis, but positive in one patient with idiopathic primary myxedema. 7) The number of patients with high titers(>l:802) was 16 for antithyroglobulin antibody, and 62.5% (10 patients) of which was Hashimoto's thyroiditis. Thirteen (65.0) of 20 patients with high titers (>l:802) for antimicrosomal antibody was Hashimoto's thyroiditis. TRCH test is a simple, sensitive method, and has high reliability and reproducibility. The incidences and titers of antithyroglobulin antibody and antimicrosomal antibody are especially high in Hashimoto's thyroiditis.

  4. [Antimalaria fluorescent antibodies evolution in young children living in a stable malaria area (author's transl)].

    Science.gov (United States)

    Nozais, J P; Ky, D T; Doucet, J

    1979-01-01

    The detection of malarial fluorescent antibodies have been performed in an Abidjan dispensary on 30 newborn babies with their mothers, 30 children 3 months old and 120 children from 6 to 24 months. This survey took place during the small rainy season and it demonstrates that: --synthesis of specific antibodies is significantly starting after the 3rd month; --the rise, after six months, of the malarial antibodies is parallel to the plasmodic index checked during the same period in the same area; --the rate of antibodies in 2 years old babies is almost the same that in adults; --living conditions in rural areas accelerate the synthesis of antibodies which, adversely, is slowed down by regular chemoprophylaxis; --Plasmodium berghei is a valuable antigen for mass survey; --Abidjan town is an hypoendemic zone of stable malaria in a mesoendemic area.

  5. Compositions, antibodies, asthma diagnosis methods, and methods for preparing antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Hongjun; Zangar, Richard C.

    2017-01-17

    Methods for preparing an antibody are provided with the method including incorporating 3-bromo-4-hydroxy-benzoic acid into a protein to form an antigen, immunizing a mammalian host with the antigen, and recovering an antibody having an affinity for the antigen from the host. Antibodies having a binding affinity for a monohalotyrosine are provided as well as composition comprising an antibody bound with monohalotyrosine. Compositions comprising a protein having a 3-bromo-4-hydroxy-benzoic acid moiety are also provided. Methods for evaluating the severity of asthma are provide with the methods including analyzing sputum of a patient using an antibody having a binding affinity for monohalotyrosine, and measuring the amount of antibody bound to protein. Methods for determining eosinophil activity in bodily fluid are also provided with the methods including exposing bodily fluid to an antibody having a binding affinity for monohalotyrosine, and measuring the amount of bound antibody to determine the eosinophil activity.

  6. Is there a need for special preventive medical check-ups in employees exposed to experimental animal dust?

    Science.gov (United States)

    Schmid, Klaus; Jüngert, Barbara; Hager, Meta; Drexler, Hans

    2009-02-01

    Due to new legal requirements in Germany, the employer must request preventive medical check-ups for activities involving exposure to dust from experimental animals in the rooms in which the animals are kept. The objective is to report our first experiences with these medical check-ups in the context of academic research. The check-ups were carried out since November 2005 and comprised a questionnaire and a medical examination, including a pulmonary function test with whole-body plethysmography. Respiratory, nasal and ocular symptoms related to occupational exposure to animals were documented. Participation in skin prick tests (ubiquitous inhalation allergens and laboratory animal allergens), a bronchial provocation test with methacholine, and serological examinations for total IgE and specific IgE antibodies was voluntary. Data on 132 persons are presented. One hundred and six of these had already been exposed for at least 1 year. Main complaints at the workplace were sneezing and runny nose. Ocular symptoms and bronchial asthma were reported infrequently. The development of at least one of these symptoms occurred in 34% of employees with an exposure of at least 1 year. If the weekly exposure duration was at least 5 h, the proportion of employees with complaints rose to 44.9%. In employees occupationally exposed to mice and rats, work-related complaints occurred in 33.7 and 37.8%, respectively, and sensitisation rates were 12.7 and 16.3%, respectively. Employees with and without complaints differed in history of allergic symptoms, and workplace safety measures. In employees with occupational contact with laboratory animal dust, the frequency of complaints was high. The results confirm the necessity of regular medical check-ups for employees with contact with laboratory animal dust. Nevertheless, the medical check-ups must be part of a prevention strategy including education, engineering controls, administrative controls, use of personal protective equipment and

  7. Antithyroid microsomal antibody

    Science.gov (United States)

    ... that you have a higher chance of developing thyroid disease in the future. Antithyroid microsomal antibodies may be ... PA: Elsevier; 2016:chap 11. Weiss RE, Refetoff S. Thyroid function testing. In: Jameson JL, De Groot LJ, eds. Endocrinology: Adult and ... Lupus Read more ...

  8. Antibodies Targeting EMT

    Science.gov (United States)

    2017-10-01

    determine their targets on the cell. The newly discovered antibodies will then be engineered for utility as new highly specific drugs and diagnostics in...are from the aldo-keto reductase family (AKRs). Remarkably, 3 of the top 10 genes with induction in the mesenchymal TES2b cells Figure 1. Amino

  9. Monoclonal antibodies in haematopathology

    Energy Technology Data Exchange (ETDEWEB)

    Grignani, F.; Martelli, M.F.; Mason, D.Y.

    1985-01-01

    This book contains over 40 selections. Some of the titles are: Oncogene (c-myc, c-myb) amplification in acute myelogenous leukaemia; Ultrastructural characterization of leukaemic cells with monoloclonal antibodies; Origin of B-cell malignancies; Immunohistology of gut lymphomas; and Spurious evidence of lineage infidelity in monocytic leukaemia.

  10. Monoclonal antibodies in myeloma

    DEFF Research Database (Denmark)

    Sondergeld, P.; van de Donk, N. W. C. J.; Richardson, P. G.

    2015-01-01

    The development of monoclonal antibodies (mAbs) for the treatment of disease goes back to the vision of Paul Ehrlich in the late 19th century; however, the first successful treatment with a mAb was not until 1982, in a lymphoma patient. In multiple myeloma, mAbs are a very recent and exciting add...

  11. Estimated emission reductions from California's enhanced Smog Check program.

    Science.gov (United States)

    Singer, Brett C; Wenzel, Thomas P

    2003-06-01

    The U.S. Environmental Protection Agency requires that states evaluate the effectiveness of their vehicle emissions inspection and maintenance (I/M) programs. This study demonstrates an evaluation approach that estimates mass emission reductions over time and includes the effect of I/M on vehicle deterioration. It includes a quantitative assessment of benefits from pre-inspection maintenance and repairs and accounts for the selection bias effect that occurs when intermittent high emitters are tested. We report estimates of one-cycle emission benefits of California's Enhanced Smog Check program, ca. 1999. Program benefits equivalent to metric tons per day of prevented emissions were calculated with a "bottom-up" approach that combined average per vehicle reductions in mass emission rates (g/gal) with average per vehicle activity, resolved by model year. Accelerated simulation mode test data from the statewide vehicle information database (VID) and from roadside Smog Check testing were used to determine 2-yr emission profiles of vehicles passing through Smog Check and infer emission profiles that would occur without Smog Check. The number of vehicles participating in Smog Check was also determined from the VID. We estimate that in 1999 Smog Check reduced tailpipe emissions of HC, CO, and NO(x) by 97, 1690, and 81 t/d, respectively. These correspond to 26, 34, and 14% of the HC, CO, and NO(x) that would have been emitted by vehicles in the absence of Smog Check. These estimates are highly sensitive to assumptions about vehicle deterioration in the absence of Smog Check. Considering the estimated uncertainty in these assumptions yields a range for calculated benefits: 46-128 t/d of HC, 860-2200 t/d of CO, and 60-91 t/d of NO(x). Repair of vehicles that failed an initial, official Smog Check appears to be the most important mechanism of emission reductions, but pre-inspection maintenance and repair also contributed substantially. Benefits from removal of nonpassing

  12. Model Checking Temporal Logic Formulas Using Sticker Automata

    Directory of Open Access Journals (Sweden)

    Weijun Zhu

    2017-01-01

    Full Text Available As an important complex problem, the temporal logic model checking problem is still far from being fully resolved under the circumstance of DNA computing, especially Computation Tree Logic (CTL, Interval Temporal Logic (ITL, and Projection Temporal Logic (PTL, because there is still a lack of approaches for DNA model checking. To address this challenge, a model checking method is proposed for checking the basic formulas in the above three temporal logic types with DNA molecules. First, one-type single-stranded DNA molecules are employed to encode the Finite State Automaton (FSA model of the given basic formula so that a sticker automaton is obtained. On the other hand, other single-stranded DNA molecules are employed to encode the given system model so that the input strings of the sticker automaton are obtained. Next, a series of biochemical reactions are conducted between the above two types of single-stranded DNA molecules. It can then be decided whether the system satisfies the formula or not. As a result, we have developed a DNA-based approach for checking all the basic formulas of CTL, ITL, and PTL. The simulated results demonstrate the effectiveness of the new method.

  13. Deployment of check-in nodes in complex networks

    Science.gov (United States)

    Jiang, Zhong-Yuan; Ma, Jian-Feng

    2017-01-01

    In many real complex networks such as the city road networks and highway networks, vehicles often have to pass through some specially functioned nodes to receive check-in like services such as gas supplement at gas stations. Based on existing network structures, to guarantee every shortest path including at least a check-in node, the location selection of all check-in nodes is very essential and important to make vehicles to easily visit these check-in nodes, and it is still remains an open problem in complex network studies. In this work, we aim to find possible solutions for this problem. We first convert it into a set cover problem which is NP-complete and propose to employ the greedy algorithm to achieve an approximate result. Inspired by heuristic information of network structure, we discuss other four check-in node location deployment methods including high betweenness first (HBF), high degree first (HDF), random and low degree first (LDF). Finally, we compose extensive simulations in classical scale-free networks, random networks and real network models, and the results can well confirm the effectiveness of the greedy algorithm. This work has potential applications into many real networks.

  14. Advanced non-disruptive manufacturing rule checks (MRC)

    Science.gov (United States)

    Moore, Bill; Do, Tanya; Morgan, Ray E.

    2006-10-01

    New advanced mask rule checking (MRC) solutions are required to ensure cost effective, high yield photomask manufacturing processes at 65nm and below and are needed to provide new verification capabilities for mask makers and data prep engineers alike. Traditional MRC, which implements fundamental geometric data checks on limited data formats, is not sufficient for advanced photomask manufacturing. Like recent advances in design rule checking (DRC) software, which includes extensive "manufacturing-aware" rules (or DFM rules), MRC solutions must evolve to include a more comprehensive and intelligent rule checks for the mask manufacturing process. This paper describes the development and testing of an advanced MRC software solution developed within the CATS TM mask data preparation (MDP) solution from Synopsys Inc. The new MRC solution enables the inspection and analysis of mask layout patterns for simple and advanced data verification checks. Proposed applications for mask data prep applications are discussed and include incoming design verification, fracture data correction, inspection tool data tags, mask manufacturing tool or inspection tool selection, and job deck verification.

  15. Intelligent Data Visualization for Cross-Checking Spacecraft System Diagnosis

    Science.gov (United States)

    Ong, James C.; Remolina, Emilio; Breeden, David; Stroozas, Brett A.; Mohammed, John L.

    2012-01-01

    Any reasoning system is fallible, so crew members and flight controllers must be able to cross-check automated diagnoses of spacecraft or habitat problems by considering alternate diagnoses and analyzing related evidence. Cross-checking improves diagnostic accuracy because people can apply information processing heuristics, pattern recognition techniques, and reasoning methods that the automated diagnostic system may not possess. Over time, cross-checking also enables crew members to become comfortable with how the diagnostic reasoning system performs, so the system can earn the crew s trust. We developed intelligent data visualization software that helps users cross-check automated diagnoses of system faults more effectively. The user interface displays scrollable arrays of timelines and time-series graphs, which are tightly integrated with an interactive, color-coded system schematic to show important spatial-temporal data patterns. Signal processing and rule-based diagnostic reasoning automatically identify alternate hypotheses and data patterns that support or rebut the original and alternate diagnoses. A color-coded matrix display summarizes the supporting or rebutting evidence for each diagnosis, and a drill-down capability enables crew members to quickly view graphs and timelines of the underlying data. This system demonstrates that modest amounts of diagnostic reasoning, combined with interactive, information-dense data visualizations, can accelerate system diagnosis and cross-checking.

  16. Humanized Antibodies for Antiviral Therapy

    Science.gov (United States)

    Co, Man Sung; Deschamps, Marguerite; Whitley, Richard J.; Queen, Cary

    1991-04-01

    Antibody therapy holds great promise for the treatment of cancer, autoimmune disorders, and viral infections. Murine monoclonal antibodies are relatively easy to produce but are severely restricted for therapeutic use by their immunogenicity in humans. Production of human monoclonal antibodies has been problematic. Humanized antibodies can be generated by introducing the six hypervariable regions from the heavy and light chains of a murine antibody into a human framework sequence and combining it with human constant regions. We humanized, with the aid of computer modeling, two murine monoclonal antibodies against herpes simplex virus gB and gD glycoproteins. The binding, virus neutralization, and cell protection results all indicate that both humanized antibodies have retained the binding activities and the biological properties of the murine monoclonal antibodies.

  17. Is raised helicobacter pylori antibody titre enough to decide retreatment

    International Nuclear Information System (INIS)

    Bibi, S.; Ahmed, W.; Arif, A.; Alam, S.E.

    2011-01-01

    Background: Helicobacter pylori infection causes a rise in its antibodies which take almost a year to come to baseline following successful eradication treatment. Checking these values in between a year may give falsely high values and many patients may thus be over treated. Aims: To serially determine Helicobacter pylori antibody titres in patients after giving them triple therapy for H. pylori eradication and see how these values drop over time. Study type, Settings and duration: Longitudinal study conducted in Department of Gastroenterology and Hepatology, Pakistan Medical Research Council, Research Centre, Jinnah Post Graduate Medical Centre, Karachi, from May 2006 to April 2010. Subjects and Methods: Over the period of four years, 186 patients who were found positive for campylobacter like organism test during endoscopy were further tested for anti H. pylori IgG titre before being treated for H. pylori. Patients were given triple therapy comprising of Omeprazole (20 mg twice daily), Amoxicillin (1 gm twice daily) and Clarythromycin (500 mg twice daily) for a week and were followed at 1, 3, 6 and 12 months to check symptomatic relief and they were tested again for H.Pylori antibody titres. Data was collected on pre-designed proforma which included patient's demography, symptoms and diagnosis. Results: Out of 186 patients who had a positive campylobacter like organism test, 173 patients consented to participate in the study. Serology for H.Pylori was positive in 119(68%) cases. A decline in mean antibody titres was observed as 11%, 21.5%, 54.7% and 59.2% at 1, 3, 6 and 12 months respectively. Conclusions: Sensitivity of serology for diagnosing H. pylori infection is good but using these as a tool for monitoring response to treatment is doubtful. A slow drop in H.pylori antibodies was seen over 12 months and therefore, physicians are cautioned not to retreat the already treated cases till about one year post treatment. Policy message: H. pylori antibodies should

  18. The use of check valve performance data to support new concepts (probabilistic risk assessment, condition monitoring) for check valve program

    Energy Technology Data Exchange (ETDEWEB)

    Hart, K.A.; Gower, D.

    1996-12-01

    The concept of developing an integrated check valve database based on the Nuclear Power Reliability Data System (NPRDS) data was presented at the last Symposium. The Nuclear Industry Check Valve Group (NIC), working in cooperation with the Oak Ridge National Laboratory (ORNL), has completed an operational database of check valve performance from 1984 to the present. NIC has committed to the nuclear industry to periodically update the data and maintain this information accessible. As the new concepts of probabilistic risk analysis and condition monitoring are integrated into the American Society of Mechanical Engineers (ASME) Code, a critical element will be performance data. From check valve performance data, feasible failure modes and rates can be established. When a failure rate or frequency of failures can be established based on a significant enough population (sampling), a more solid foundation for focusing resources and determining appropriate frequencies and testing can be determined. The presentation will give the updated status of the NIC Check Valve Performance Database covering (1) methodology used to combine the original ORNL data; (2) process/controls established for continuing update and refinement of the data; (3) discussion of how this data is being utilized by (a) OM-22 for condition monitoring, and (b) risk-based inservice testing work of Westinghouse Owners` Group; and (4) results/trends of data evaluations. At the 1994 Symposium, ORNL provided an update as of 1991 to their original work of 1984 -1990 which they had performed to characterize check valve degradations and failures in the nuclear industry. These characterizations will be updated to 1995 and additional reviews provided to give insight into the current condition and trends of check valve performance.

  19. Structural Characterization of Peptide Antibodies

    DEFF Research Database (Denmark)

    Chailyan, Anna; Marcatili, Paolo

    2015-01-01

    The role of proteins as very effective immunogens for the generation of antibodies is indisputable. Nevertheless, cases in which protein usage for antibody production is not feasible or convenient compelled the creation of a powerful alternative consisting of synthetic peptides. Synthetic peptides...... can be modified to obtain desired properties or conformation, tagged for purification, isotopically labeled for protein quantitation or conjugated to immunogens for antibody production. The antibodies that bind to these peptides represent an invaluable tool for biological research and discovery...

  20. Synthetic peptides for antibody production

    NARCIS (Netherlands)

    N.D. Zegers (Netty)

    1995-01-01

    textabstractSynthetic peptides are useful tools for the generation of antibodies. The use of antibodies as specific reagents in inununochemical assays is widely applied. In this chapter, the application of synthetic peptides for the generation of antibodies is described. The different steps

  1. Synthetic peptides for antibody production

    NARCIS (Netherlands)

    Zegers, N.D.

    1995-01-01

    Synthetic peptides are useful tools for the generation of antibodies. The use of antibodies as specific reagents in inununochemical assays is widely applied. In this chapter, the application of synthetic peptides for the generation of antibodies is described. The different steps that lead to the

  2. Applied Bounded Model Checking for Interlocking System Designs

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Peleska, Jan; Pinger, Ralf

    2013-01-01

    In this article the verification and validation of interlocking systems is investigated. Reviewing both geographical and route-related interlocking, the verification objectives can be structured from a perspective of computer science into (1) verification of static semantics, and (2) verification...... of behavioural (operational) semantics. The former checks that the plant model – that is, the software components reflecting the physical components of the interlocking system – has been set up in an adequate way. The latter investigates trains moving through the network, with the objective to uncover potential...... safety violations. From a formal methods perspective, these verification objectives can be approached by theorem proving, global, or bounded model checking. This article explains the techniques for application of bounded model checking techniques, and discusses their advantages in comparison...

  3. CheckMATE 2: From the model to the limit

    Science.gov (United States)

    Dercks, Daniel; Desai, Nishita; Kim, Jong Soo; Rolbiecki, Krzysztof; Tattersall, Jamie; Weber, Torsten

    2017-12-01

    We present the latest developments to the CheckMATE program that allows models of new physics to be easily tested against the recent LHC data. To achieve this goal, the core of CheckMATE now contains over 60 LHC analyses of which 12 are from the 13 TeV run. The main new feature is that CheckMATE 2 now integrates the Monte Carlo event generation via MadGraph5_aMC@NLO and Pythia 8. This allows users to go directly from a SLHA file or UFO model to the result of whether a model is allowed or not. In addition, the integration of the event generation leads to a significant increase in the speed of the program. Many other improvements have also been made, including the possibility to now combine signal regions to give a total likelihood for a model.

  4. Statistical Model Checking of Rich Models and Properties

    DEFF Research Database (Denmark)

    Poulsen, Danny Bøgsted

    Software is in increasing fashion embedded within safety- and business critical processes of society. Errors in these embedded systems can lead to human casualties or severe monetary loss. Model checking technology has proven formal methods capable of finding and correcting errors in software...... motivates why existing model checking technology should be supplemented by new techniques. It also contains a brief introduction to probability theory and concepts covered by the six papers making up the second part. The first two papers are concerned with developing online monitoring techniques...... systems. The fifth paper shows how stochastic hybrid automata are useful for modelling biological systems and the final paper is concerned with showing how statistical model checking is efficiently distributed. In parallel with developing the theory contained in the papers, a substantial part of this work...

  5. LOAD-CHECK. Disposal planning for LWR fuel elements

    International Nuclear Information System (INIS)

    Freunek, M.; Braun, A.; Graf, R.; Gutermuth, F.

    2012-01-01

    With the changes of the German atomic law from November 8, 2011 the operation licensing of LWR plants expire latest 2022, for eight NPPs the operation licenses are already expired. In order to optimize the fuel element management in the still operated but also in the decommissioned nuclear power plants the computer code module LOAD-CHECK was developed. LOAD-CHECK allows the foresight container planning for an optimized schedule and the container amount for loading campaigns esp. in case of the disposal of special fuel elements (MOX fuel elements or high-burnup fuel elements). The program can also be used a s tool for development of transport licensing and storage licensing according of CASTOR registered V casks. In the contribution the LOAD-CHECK program for the PWR and BWR fuel element disposal management in CASTOR registered B casks is presented.

  6. Magnetic Purification of Antibodies

    Science.gov (United States)

    Dhadge, Vijaykumar Laxman

    This work aimed at the development of magnetic nanoparticles for antibody purification and at the evaluation of their performance in Magnetic fishing and in a newly developed hybrid technology Magnetic Aqueous Two Phase Systems. Magnetic materials were produced by coprecipitation and solvothermal approaches. Natural polymers such as dextran, extracellular polysaccharide and gum Arabic were employed for coating of iron oxide magnetic supports. Polymer coated magnetic supports were then modified with synthetic antibody specific ligands,namely boronic acid, a triazine ligand (named 22/8) and an Ugi ligand (named A2C7I1). To optimize the efficacy of magnetic nanoparticles for antibody magnetic fishing, various solutions of pure and crude antibody solutions along with BSA as a non-specific binding protein were tested. The selectivity of magnetic nanoparticle for antibody, IgG, was found effective with boronic acid and ligand 22/8. Magnetic supports were then studied for their performance in high gradient magnetic separator for effective separation capability as well as higher volume handling capability. The magnetic materials were also supplemented to aqueous two phase systems, devising a new purification technology. For this purpose, magnetic particles modified with boronic acid were more effective. This alternative strategy reduced the time of operation,maximized separation capability (yield and purity), while reducing the amount of salt required. Boronic acid coated magnetic particles bound 170 +/- 10 mg hIgG/g MP and eluted 160 +/- 5 mg hIgG/g MP, while binding only 15 +/- 5 mg BSA/g MP. The affinity constant for the interaction between hIgG and APBA_MP was estimated as 4.9 x 105 M-1 (Ka) with a theoretical maximum capacity of 492 mg hIgG adsorbed/g MP (Qmax). APBA_MPs were also tested for antibody purification directly from CHO cell supernatants. The particles were able to bind 98% of IgG loaded and to recover 95% of pure IgG (purity greater than 98%) at extremely

  7. Forgetting what you have checked: a link between working memory impairment and checking behaviors in obsessive-compulsive disorder.

    Science.gov (United States)

    Jaafari, N; Frasca, M; Rigalleau, F; Rachid, F; Gil, R; Olié, J-P; Guehl, D; Burbaud, P; Aouizerate, B; Rotgé, J-Y; Vibert, N

    2013-02-01

    Compulsive checking behaviors are common in obsessive-compulsive disorder (OCD). Several authors have suggested that these checking rituals could be related to memory deficits. Our aim was to test whether patients with OCD show working memory impairment in relation to their checking behavior. We evaluated the verbal and visuospatial components of patients' and controls' working memory using the reading span and backward location span tests. Checking behaviors were measured by recording participants' eye movements during an image comparison task using a non-invasive, infra-red TOBII 1750 eyetracker. Participants were seated, head-free, in a natural position in front of the eyetracker screen where the images were displayed. Patients with OCD made more gaze moves to compare images than controls. Both patients' working memory spans were reduced, and the patients' deficit in the comparison task was negatively related to their working memory spans. This work demonstrates that checking behavior in OCD is linked to a general reduction of the patients' verbal and visuospatial working memory span. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  8. A procedure for routine radiation protection checking of mammography equipment

    International Nuclear Information System (INIS)

    Bengtsson, L.G.; Lundehn, I.

    1980-01-01

    A procedure was developed for checking of mammography equipment used in screening for mammary cancer. The procedure will be handled by hospital physicists or x-ray inspectors and is intended to permit checking of x-ray equipment performance as well as evaluation of mean dose or eneray imparted to groups of patients. Measurement methods studied involve TLD, ionization chambers and a new plastic scintillator designed to measure energy imparted. After careful study of sizes and attenuation properties of breasts, a 50 mm polymethylmetacrylate phantom seemed the most appropriate. The choice of measuring equipment is reported as well as some preliminary results from field measurements. (author)

  9. Clinical use of antibodies

    International Nuclear Information System (INIS)

    Baum, R.P.; Hoer, Gustav; Cox, P.H.; Buraggi, G.L.

    1991-01-01

    Use of monoclonal antibodies as tumour specific carrier molecules for therapeutic agents or as in vivo diagnostic reagents when labelled with radionuclides or NMR signal enhancers is attracting more and more attention. The potential is enormous but the technical problems are also considerable requiring the concerted action of many different scientific disciplines. This volume is based upon a symposium organised in Frankfurt in 1990 under the auspices of the European Association of Nuclear Medicines' Specialist Task Groups on Cardiology and the Utility of Labelled Antibodies. It gives a multidisciplinary review of the state of the art and of problems to be solved as well as recording the not inconsiderable successes which have been booked to date. The book will be of value as a reference to both clinicians and research scientists. refs.; figs.; tabs

  10. Antibody Production with Synthetic Peptides.

    Science.gov (United States)

    Lee, Bao-Shiang; Huang, Jin-Sheng; Jayathilaka, Lasanthi P; Lee, Jenny; Gupta, Shalini

    2016-01-01

    Peptides (usually 10-20 amino acid residues in length) can be used as effectively as proteins in raising antibodies producing both polyclonal and monoclonal antibodies routinely with titers higher than 20,000. Peptide antigens do not function as immunogens unless they are conjugated to proteins. Production of high quality antipeptide antibodies is dependent upon peptide sequence selection, the success of peptide synthesis, peptide-carrier protein conjugation, the humoral immune response in the host animal, the adjuvant used, the peptide dose administered, the injection method, and the purification of the antibody. Peptide sequence selection is probably the most critical step in the production of antipeptide antibodies. Although the process for designing peptide antigens is not exact, several guidelines and computational B-cell epitope prediction methods can help maximize the likelihood of producing antipeptide antibodies that recognize the protein. Antibodies raised by peptides have become essential tools in life science research. Virtually all phospho-specific antibodies are now produced using phosphopeptides as antigens. Typically, 5-20 mg of peptide is enough for antipeptide antibody production. It takes 3 months to produce a polyclonal antipeptide antibody in rabbits that yields ~100 mL of serum which corresponds to ~8-10 mg of the specific antibody after affinity purification using a peptide column.

  11. Remedial Sheets for Progress Checks, Segments 1-14.

    Science.gov (United States)

    New York Inst. of Tech., Old Westbury.

    The first part of the Self-Paced Physics Course remediation materials is presented for U. S. Naval Academy students who miss core problems on the progress check. The total of 78 problems is incorporated in this volume to match study segments 1 through 14. Each remedial sheet is composed of a statement of the missed problem and references to…

  12. Remedial Sheets for Progress Checks, Segments 19-40.

    Science.gov (United States)

    New York Inst. of Tech., Old Westbury.

    The second part of the Self-Paced Physics Course remediation materials is presented for U. S. Naval Academy students who miss core problems on the progress check. The total of 101 problems is incorporated in this volume to match study segments 19 through 40. Each remedial sheet is composed of a statement of the missed problem and references to…

  13. Model-Checking CTL* over Flat Presburger Counter Systems

    DEFF Research Database (Denmark)

    Demri, Stéphane; Finkel, Alain; Goranko, Valentin

    2010-01-01

    This paper studies model-checking of fragments and extensions of CTL* on infinite- state counter systems, where the states are vectors of integers and the transitions are determined by means of relations definable within Presburger arithmetic. In general, reachability properties of counter system...

  14. A review of historical check valve failure data

    International Nuclear Information System (INIS)

    Casada, D.A.; Todd, M.D.

    1992-01-01

    Check valve operating problems in recent years have resulted in significant operating transients, increased cost, and decreased system availability. In response, additional attention has been given to check valves by utilities, as well as the US Nuclear Regulatory Commission (NRC) and the American Society of Mechanical Engineers Operation and Maintenance Committee. All these organizations have the fundamental goal of ensuring reliable operation of check valves. A key ingredient of an engineering-oriented reliability improvement effort is a thorough understanding of relevant historical experience. Oak Ridge National Laboratory is currently conducting a detailed review of historical failure data available through the Institute of Nuclear Power Operation's Nuclear Plant Reliability Data System. The focus of the review is on check valve failures that have involved significant degradation of the valve internal parts. A variety of parameters are being considered during the review, including size, age, system of service, method of failure discovery, the affected valve parts, attributed causes, and corrective actions. This work is being carried out under the auspices of the NRC's Nuclear Plant Aging Research program. At this time, the study is approximately 50% complete. All failure records have been reviewed and categorized, and preliminary tabulation and correlation of data is underway. The bulk of the tabulation and correlation portion of the work is expected to be completed by the end of June 1992. A report draft is expected in the fall of 1992

  15. Mandatory Identification Bar Checks: How Bouncers Are Doing Their Job

    Science.gov (United States)

    Monk-Turner, Elizabeth; Allen, John; Casten, John; Cowling, Catherine; Gray, Charles; Guhr, David; Hoofnagle, Kara; Huffman, Jessica; Mina, Moises; Moore, Brian

    2011-01-01

    The behavior of bouncers at on site establishments that served alcohol was observed. Our aim was to better understand how bouncers went about their job when the bar had a mandatory policy to check identification of all customers. Utilizing an ethnographic decision model, we found that bouncers were significantly more likely to card customers that…

  16. checkCIF/PLATON report Datablock: Compound_I

    Indian Academy of Sciences (India)

    4 ALERT level G = General information/check it is not something unexpected. 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 1 ALERT type 2 Indicator that the structure model may be wrong or deficient. 1 ALERT type 3 Indicator that the structure quality may be low. 1 ALERT type 4 Improvement, ...

  17. Model Checking Coalition Nash Equilibria in MAD Distributed Systems

    Science.gov (United States)

    Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico; Alvisi, Lorenzo; Clement, Allen; Li, Harry

    We present two OBDD based model checking algorithms for the verification of Nash equilibria in finite state mechanisms modeling Multiple Administrative Domains (MAD) distributed systems with possibly colluding agents (coalitions) and with possibly faulty or malicious nodes (Byzantine agents). Given a finite state mechanism, a proposed protocol for each agent and the maximum sizes f for Byzantine agents and q for agents collusions, our model checkers return PASS if the proposed protocol is an ɛ-f-q-Nash equilibrium, i.e. no coalition of size up to q may have an interest greater than ɛ in deviating from the proposed protocol when up to f Byzantine agents are present, FAIL otherwise. We implemented our model checking algorithms within the NuSMV model checker: the first one explicitly checks equilibria for each coalition, while the second represents symbolically all coalitions. We present experimental results showing their effectiveness for moderate size mechanisms. For example, we can verify coalition Nash equilibria for mechanisms which corresponding normal form games would have more than 5 ×1021 entries. Moreover, we compare the two approaches, and the explicit algorithm turns out to outperform the symbolic one. To the best of our knowledge, no model checking algorithm for verification of Nash equilibria of mechanisms with coalitions has been previously published.

  18. Interactive comparison of hypothesis tests for statistical model checking

    NARCIS (Netherlands)

    de Boer, Pieter-Tjerk; Reijsbergen, D.P.; Scheinhardt, Willem R.W.

    2015-01-01

    We present a web-based interactive comparison of hypothesis tests as are used in statistical model checking, providing users and tool developers with more insight into their characteristics. Parameters can be modified easily and their influence is visualized in real time; an integrated simulation

  19. checkCIF/PLATON report Datablock: exp_3145

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  20. checkCIF/PLATON report Datablock: fa083

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. Structure factors have been supplied for datablock(s) fa083. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors ...

  1. checkCIF/PLATON report Datablock: gitam035

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. Structure factors have been supplied for datablock(s) gitam035. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax ...

  2. checkCIF/PLATON report Datablock: rup-re

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  3. checkCIF/PLATON report Datablock: compound1

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  4. 7 CFR 70.55 - Check grading officially identified product.

    Science.gov (United States)

    2010-01-01

    ... AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT... 7 Agriculture 3 2010-01-01 2010-01-01 false Check grading officially identified product. 70.55 Section 70.55 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING...

  5. The humble Bayesian : Model checking from a fully Bayesian perspective

    NARCIS (Netherlands)

    Morey, Richard D.; Romeijn, Jan-Willem; Rouder, Jeffrey N.

    Gelman and Shalizi (2012) criticize what they call the usual story in Bayesian statistics: that the distribution over hypotheses or models is the sole means of statistical inference, thus excluding model checking and revision, and that inference is inductivist rather than deductivist. They present

  6. Apparatus for checking the dimensions of nuclear fuel pellets

    International Nuclear Information System (INIS)

    Marmo, A.R.

    1978-01-01

    The description is given of an apparatus for checking the dimensions of pellets comprising a housing, a feeding device near this housing to move a pellet towards the latter and away from it, and a platform with a hole, this platform being fitted to the housing near the feeding system in order to hold the pellet [fr

  7. First experiences with the LHC BLM sanity checks

    CERN Document Server

    Emery, J; Effinger, E; Nordt, A; Sapinski, M G; Zamantzas, C

    2010-01-01

    The reliability concerns have driven the design of the Large Hardron Collider (LHC) Beam Loss Monitoring (BLM) system from the early stage of the studies up to the present commissioning and the latest development of diagnostic tools. To protect the system against non-conformities, new ways of automatic checking have been developed and implemented. These checks are regularly and systematically executed by the LHC operation team to ensure that the system status is after each test "as good as new". The sanity checks are part of this strategy. They are testing the electrical part of the detectors (ionisation chamber or secondary emission detector), their cable connections to the front-end electronics, further connections to the back-end electronics and their ability to request a beam abort. During the installation and in the early commissioning phase, these checks have shown their ability to find also non-conformities caused by unexpected failure event scenarios. In every day operation, a non-conformity discovere...

  8. Recent advances in importance sampling for statistical model checking

    NARCIS (Netherlands)

    Reijsbergen, D.P.; de Boer, Pieter-Tjerk; Scheinhardt, Willem R.W.; Haverkort, Boudewijn R.H.M.

    2013-01-01

    In the following work we present an overview of recent advances in rare event simulation for model checking made at the University of Twente. The overview is divided into the several model classes for which we propose algorithms, namely multicomponent systems, Markov chains and stochastic Petri

  9. checkCIF/PLATON report Datablock: rupret_0m

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  10. checkCIF/PLATON report Datablock: 8_plus_2

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. You have not supplied any structure factors. As a result the full set of tests cannot be run. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC ...

  11. Radiation therapy plan checks in a paperless clinic.

    Science.gov (United States)

    Siochi, R Alfredo; Pennington, Edward C; Waldron, Timothy J; Bayouth, John E

    2009-01-27

    Traditional quality assurance checks of a patient's radiation therapy plan involve printing out treatment parameters from the treatment planning system and the "record and verify" (R&V) system and visually checking the information for one-to-one correspondence. In a paperless environment, one can automate this process through independent software that can read the treatment planning data directly and compare it against the parameters in the R&V system's database. In addition to verifying the data integrity, it is necessary to check the logical consistency of the data and the accuracy of various calculations. The results are then imported into the patient's electronic medical record. Appropriate workflows must be developed to ensure that no steps of the QA process are missed. This paper describes our electronic QA system (EQS), consisting of in-house software and workflows. The EQS covers 3D conformal and intensity modulated radiation therapy, electrons, stereotactic radiosurgery, total body irradiation, and clinical set ups with and without virtual simulation. The planning systems handled by our EQS are ADAC Pinnacle and Varian FASTPLAN, while the R&V systems are LANTIS and VARIS. The improvement in our plan check process over the paperless system is described in terms of the types of detected errors. The potential problems with the implementation and use of the EQS, as well as workarounds for data that are not easily accessible through electronic means, are described.

  12. Check list of the Hungarian Salticidae with biogeographical notes

    Directory of Open Access Journals (Sweden)

    Szüts, Tamás

    2003-04-01

    Full Text Available An updated check list of the Hungarian jumping spider fauna is presented. 70 species are recorded from Hungary so far. Four species are new to the Hungarian fauna: Hasarius adansoni, Neon valentulus, Sitticus caricis, Synageles subcingulatus. With 12 original drawings.

  13. Check list of the helminths of equines in Turkey.

    Science.gov (United States)

    Gürler, Ali Tümay; Bölükbaş, Cenk Soner; Açici, Mustafa; Umur, Sinasi

    2010-01-01

    Helminths of equines are one of the most important agents of parasitic diseases. Therefore, many studies have been conducted on helminths of equines in Turkey. In this article, a check list and prevalence rates of helminths of equines in Turkey have been given.

  14. Check list of European hymenomycetous Heterobasidiae. Supplement and corrections

    NARCIS (Netherlands)

    Donk, M.A.

    1974-01-01

    This continuation of the “Check list of European hymenomycetous Heterobasidiae” (published in Persoonia 4: 145-335. 1966) contains supplementary matter as well as corrections. — Ypsilonidium (Donk) Donk is published as a new genus. Two new specific combinations are made with this generic name. —

  15. A Check List for Evaluating Persuasive Features of Mathematics Courseware

    Science.gov (United States)

    Aris, Baharuddin; Gharbaghi, Alireza; Ahmad, Maizah Hura; Rosli, Mohd Shafie

    2013-01-01

    The main purpose of this study is to introduce a check list for evaluating persuasive features of mathematics courseware. Since mathematics is a source of anxiety among students (Zeidner & Matthews, 2010), this research is an attempt to employ persuasive features that can be used in mathematics courseware. Specifically, we sought to determine…

  16. Tradomodern Media Imperatives for Checking Modern Slavery in ...

    African Journals Online (AJOL)

    FIRST LADY

    examines the critical role of trado-modern communication media in achieving communication objectives targeted at modern slavery in contemporary society. It adopts the analytical approach in discussing how the interface between traditional and modern communication channels could be harnessed to check the alarming ...

  17. Application of Model-Checking Technology to Controller Synthesis

    DEFF Research Database (Denmark)

    David, Alexandre; Grunnet, Jacob Deleuran; Jessen, Jan Jacob

    2011-01-01

    In this paper we present two frameworks that have been implemented to link traditional model-checking techniques to the domain of control. The techniques are based on solving a timed game and using the resulting solution (a strategy) as a controller. The obtained discrete controller must fit with...

  18. MEMS design rule checking: a batch approach for remote operation

    Energy Technology Data Exchange (ETDEWEB)

    Yarberry, V.R.

    1998-01-01

    This paper describes a design rule checking (DRC) tool developed as an aid for designing microelectromechanical structures (MEMS) using AutoCAD running on a Windows NT workstation. The application suite, MEMSdrc, consists of: a graphical user interface integrated into AutoCAD to invoke DRC, translation and interface software to communicate with a commercial IC layout design checking software package, and routines to interactively display and review the results. The user interface provides the capability to select a checking window area and specific DRC rules to be applied to the design. The MEMS structures, defined as 2D AutoCAD geometry are translated first into DXF format, then to GDSII format. A remote process transfers the files to a Unix workstation where Mentor Graphics ICverify is invoked to perform the layout design rule checks. Upon completion, the results are translated into DXF geometry and returned back to the Windows NT workstation to be overlaid onto the original design. A set of icons are provided for the user to interactively review the results inside of AutoCAD using a first/next/previous technique.

  19. Financial Record Checking in Surveys: Do Prompts Improve Data Quality?

    Science.gov (United States)

    Murphy, Joe; Rosen, Jeffrey; Richards, Ashley; Riley, Sarah; Peytchev, Andy; Lindblad, Mark

    2016-01-01

    Self-reports of financial information in surveys, such as wealth, income, and assets, are particularly prone to inaccuracy. We sought to improve the quality of financial information captured in a survey conducted by phone and in person by encouraging respondents to check records when reporting on income and assets. We investigated whether…

  20. 31 CFR 240.15 - Checks issued to deceased payees.

    Science.gov (United States)

    2010-07-01

    ... of death triggering action under this section is erroneous, the financial institution must advise the... death of the payee: payments for the redemption of currencies or for principal and/or interest on U.S... not be negotiated after the death of the payee. Such checks must be returned to the certifying agency...

  1. Tradomodern Media Imperatives for Checking Modern Slavery in ...

    African Journals Online (AJOL)

    Tradomodern Media Imperatives for Checking Modern Slavery in Africa: A Critical Appraisal. ... Such activities as human trafficking for prostitution or forced labour are rampant in the society today. Communication is crucial to the creation of awareness against any form of vice in the society, including modern slavery.

  2. Consistency checks in beam emission modeling for neutral beam injectors

    International Nuclear Information System (INIS)

    Punyapu, Bharathi; Vattipalle, Prahlad; Sharma, Sanjeev Kumar; Baruah, Ujjwal Kumar; Crowley, Brendan

    2015-01-01

    In positive neutral beam systems, the beam parameters such as ion species fractions, power fractions and beam divergence are routinely measured using Doppler shifted beam emission spectrum. The accuracy with which these parameters are estimated depend on the accuracy of the atomic modeling involved in these estimations. In this work, an effective procedure to check the consistency of the beam emission modeling in neutral beam injectors is proposed. As a first consistency check, at a constant beam voltage and current, the intensity of the beam emission spectrum is measured by varying the pressure in the neutralizer. Then, the scaling of measured intensity of un-shifted (target) and Doppler shifted intensities (projectile) of the beam emission spectrum at these pressure values are studied. If the un-shifted component scales with pressure, then the intensity of this component will be used as a second consistency check on the beam emission modeling. As a further check, the modeled beam fractions and emission cross sections of projectile and target are used to predict the intensity of the un-shifted component and then compared with the value of measured target intensity. An agreement between the predicted and measured target intensities provide the degree of discrepancy in the beam emission modeling. In order to test this methodology, a systematic analysis of Doppler shift spectroscopy data obtained on the JET neutral beam test stand data was carried out

  3. 40 CFR 53.52 - Leak check test.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Leak check test. 53.52 Section 53.52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) AMBIENT AIR... membrane or disk, 47 mm nominal diameter. (4) Means, such as a micro-valve, of providing a simulated leak...

  4. Accuracy Test of Software Architecture Compliance Checking Tools : Test Instruction

    NARCIS (Netherlands)

    Prof.dr. S. Brinkkemper; Dr. Leo Pruijt; C. Köppe; J.M.E.M. van der Werf

    2015-01-01

    Author supplied: "Abstract Software Architecture Compliance Checking (SACC) is an approach to verify conformance of implemented program code to high-level models of architectural design. Static SACC focuses on the modular software architecture and on the existence of rule violating dependencies

  5. Model checking: one can do much more than you think!

    NARCIS (Netherlands)

    Katoen, Joost P.

    2012-01-01

    Model checking is an automated verification technique that actively is applied to find bugs in hardware and software designs. Companies like IBM and Cadence developed their in-house model checkers, and acted as driving forces behind the design of the IEEE-standardized temporal logic PSL. On the

  6. Using GIS to check co-ordinates of genebank accessions

    NARCIS (Netherlands)

    Hijmans, R.J.; Schreuder, M.; Cruz, de la J.; Guarino, L.

    1999-01-01

    The geographic co-ordinates of the locations where germplasm accessions have been collected are usually documented in genebank databases. However, the co-ordinate data are often incomplete and may contain errors. This paper describes procedures to check for errors, to determine the cause of these

  7. checkCIF/PLATON report Datablock: 1b

    Indian Academy of Sciences (India)

    checkCIF was carefully designed to identify outliers and unusual parameters, but every test has its limitations and alerts that are not important in a particular case may appear. Conversely, the absence of alerts does not guarantee there are no aspects of the results needing attention. It is up to the individual to critically assess ...

  8. Model checking conditional CSL for continuous-time Markov chains

    DEFF Research Database (Denmark)

    Gao, Yang; Xu, Ming; Zhan, Naijun

    2013-01-01

    In this paper, we consider the model-checking problem of continuous-time Markov chains (CTMCs) with respect to conditional logic. To the end, we extend Continuous Stochastic Logic introduced in Aziz et al. (2000) [1] to Conditional Continuous Stochastic Logic (CCSL) by introducing a conditional p...

  9. 31 CFR 240.14 - Checks issued to incompetent payees.

    Science.gov (United States)

    2010-07-01

    ...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE INDORSEMENT AND PAYMENT OF CHECKS... without submission of documentary proof of the authority of the guardian or other fiduciary, with the... the certifying agency with information as to the incompetence of the payee and documentary evidence...

  10. checkCIF/PLATON report Datablock: 1b

    Indian Academy of Sciences (India)

    4 ALERT level G = General information/check it is not something unexpected. 1 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 2 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  11. checkCIF/PLATON report Datablock: exp_2816

    Indian Academy of Sciences (India)

    4 ALERT level G = General information/check it is not something unexpected. 1 ALERT type 1 CIF construction/syntax error, inconsistent or missing data. 2 ALERT type 2 Indicator that the structure ... However, the purpose of your study may justify the reported deviations and the more serious of these should normally be ...

  12. 12 CFR 229.53 - Substitute check indemnity.

    Science.gov (United States)

    2010-01-01

    ... expenses of representation) related to the substitute check. (2) Comparative negligence. (i) If a loss... negligence or failure to act in good faith, then the indemnity amount described in paragraph (b)(1) of this section shall be reduced in proportion to the amount of negligence or bad faith attributable to the...

  13. The Role of Personal Ethical Checking in Courageous School Leadership

    Science.gov (United States)

    Buskey, Frederick C.; Pitts, Eric M.

    2013-01-01

    When school leaders make calculated decisions to deviate from hierarchical or cultural directives and norms, they may be viewed as mavericks or brigands. This paper details a process of ethical checking to help differentiate ethical decisions from more arbitrary or self-serving decisions. The paper examines conflicts inherent in many professional…

  14. 1b_white_isomer-2_Check cif.pdf

    Indian Academy of Sciences (India)

    checkCIF was carefully designed to identify outliers and unusual parameters, but every test has its limitations and alerts that are not important in a particular case may appear. Conversely, the absence of alerts does not guarantee there are no aspects of the results needing attention. It is up to the individual to critically assess ...

  15. Effect-driven QuickChecking of compilers

    DEFF Research Database (Denmark)

    Midtgaard, Jan; Justesen, Mathias Nygaard; Kasting, Patrick Frederik Soelmark

    2017-01-01

    How does one test a language implementation with QuickCheck (aka. property-based testing)? One approach is to generate programs following the grammar of the language. But in a statically-typed language such as OCaml too many of these candidate programs will be rejected as ill-typed by the type ch...

  16. Astronaut James Lovell checks body temperature with oral temperature probe

    Science.gov (United States)

    1965-01-01

    Gemini 7 pilot Astronaut James A. Lovell Jr. has temperature check with oral temperature probe attached to his space suit during final preflight preparations for the Gemini 7 space mission. The temperature probe allows doctors to monitor astronauts body temperature at any time during the mission.

  17. Decentralized Consistency Checking in Cross-organizational Workflows

    NARCIS (Netherlands)

    Wombacher, Andreas

    Service Oriented Architectures facilitate loosely coupled composed services, which are established in a decentralized way. One challenge for such composed services is to guarantee consistency, i.e., deadlock-freeness. This paper presents a decentralized approach to consistency checking, which

  18. Mobile vehicle road and weather observation quality check methods

    Science.gov (United States)

    Koller, Daniel Raymond

    data quality and accuracy, requiring the development of quality checks for mobile data collection. Using OBDII-equipped automobiles and mobile collection methods, we can begin to address issues of data quality by understanding, characterizing, and demonstrating the quality of mobile system observations from operational and research environments. Several forms of quality checking can be used, including range checks, Barnes spatial checks, comparing vehicle data to road weather models, and applying Clarus quality check methodologies and algorithms to mobile observations. Development of these quality checks can lead to the future integration of mobile data into the Clarus system, data implementation for improved forecasting, maintenance decision support, and traveler safety. This paper will discuss the benefits and challenges in mobile data collection, along with how the development and implementation of a system of quality checks will improve the quality and accuracy of mobile data collection.

  19. Film dosimetry techniques used in HDR brachytherapy unit QA checks

    International Nuclear Information System (INIS)

    Wang, Y.; Zealey, W.

    2001-01-01

    Full text: An HDR brachytherapy unit quality assurance check method has been studied and developed by using film dosimetry techniques in order to assess accuracy and precision of source positioning and dwell times. Usually HDR source delivery accuracy is checked by visualisation of an autoradiograph of programmed dwell positions in a parallel linear array. In this case the developed films were analysed by computer methods. In addition, an investigation was made of curved path source delivery in an autoradiographic device with multiple, variable radial catheter channels. Ready pack verification films (Kodak X-Omat V) were exposed for source delivery in all 18 channels of the HDR unit when used with the linear array check device. Four dwell positions were selected for each channel with different dwell times and with a separation such that there would be no dose cross-over within channel positions. An additional radial five channel autoradiographic check device was used to investigate the effects of source delivery in a curved path. The developed films were processed using a document scanner and analysed by custom software in which image pixel values were converted to dose. Positioning accuracy was checked by determining the peak value within corresponding regions of interest and plotting against channel separation in the linear array device. Timing accuracy was checked against a previously determined dose versus time film calibration. The time linearity for all 18 channels was checked by averaging the dose for each of the 4 channel dwell positions and plotting the channel average versus position within a channel. To investigate the effect of curved path source delivery, a dwell position was programmed within 4 channels of radii 2,4,6 and 10 cm and one straight channel. A computer analysis of a single film can demonstrate accuracy of source position, dwell time and linearity of time. This study has shown that a time change of 0.1s can result in an 8% change in dose

  20. [Study of anti-idiotype antibodies to human monoclonal antibody].

    Science.gov (United States)

    Harada, R; Takahashi, N; Owaki, I; Kannagi, R; Endo, N; Morita, N; Inoue, M

    1992-02-01

    A human monoclonal antibody, ll-50 (IgM, lambda), was generated, which reacted specifically with a major of glycolipid present in LS174T colon cancer cells. The glycolipid antigen which reacted with the ll-50 antibody was expected to four sugar residues from its TLC mobility, and it was ascertained that the glycolipid antigen which reacted with ll-50 antibody might be Lc4 antigen [Gal beta 1----3 GLcNAc beta 1----3 Gal beta 1----4 Glc beta 1----1 Cer] judging from TLC immunostaining and ELISA when the reactivity of ll-50 antibody was tested using various pure glycolipids in 3-5 sugar residues as an antigen. Sera in patients with malignant disorders and healthy individuals were analyzed by Sandwich assay of immobilized and biotinylated ll-50 antibody. The serum of the Lc4 antigen recognized by ll-50 antibody was significantly higher in patients with malignant disorders than that in healthy individuals (p less than 0.05). Three mouse monoclonal anti-idiotype antibodies, G3, B3 and C5 (all IgG1), were generated by the immunization of BALB/c mice with ll-50 antibody. These anti-idiotype antibodies specifically bound to to human monoclonal antibody, ll-50 and had a significant inhibitory activity towards the binding of ll-50 antibody to the Lc4 antigen. This indicated that these anti-idiotype antibodies, G3, B3, and C5, were paratope-related anti-idiotype antibodies. G3, B3, and C5 were expected to define the nearest idiotope because they could mutually inhibit ll-50 antibody. Sera in patients with malignant disorders and healthy individuals were analyzed by Sandwich assay of immobilized and biotinylated anti-idiotype antibodies, G3, B3, and C5. As to the ll-50 like antibodies defined by C5 (Id-C5+), the mean serum level in patients with malignant disorders was significantly higher than that in healthy individuals (p less than 0.05). As to the ll-50 like antibodies defined by B3 (Id-B3+), the mean serum level in patients with malignant disorders was significantly higher

  1. Pre-Alignment Checks. Automotive Mechanics. Steering & Suspension. Instructor's Guide [and] Student Guide.

    Science.gov (United States)

    Spignesi, B.

    This instructional package, one in a series of individualized instructional units on automotive steering and suspension, consists of a student guide and an instructor guide dealing with prealignment checks. Covered in the module are the following steps in a prealignment check: checking the ride height of a vehicle, checking the ball joints and the…

  2. Health-related quality of life results from the phase III CheckMate 067 study

    Science.gov (United States)

    Schadendorf, Dirk; Larkin, James; Wolchok, Jedd; Hodi, F. Stephen; Chiarion-Sileni, Vanna; Gonzalez, Rene; Rutkowski, Piotr; Grob, Jean-Jacques; Cowey, C. Lance; Lao, Christopher; Wagstaff, John; Callahan, Margaret K.; Postow, Michael A.; Smylie, Michael; Ferrucci, Pier Francesco; Dummer, Reinhard; Hill, Andrew; Taylor, Fiona; Sabater, Javier; Walker, Dana; Kotapati, Srividya; Abernethy, Amy; Long, Georgina V.

    2017-01-01

    Background Nivolumab, a monoclonal antibody of immune checkpoint programmed death 1 on T cells (PD-1), combined with ipilimumab, an immune checkpoint cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor, as combination therapy on the one hand and nivolumab as monotherapy on the other, have both demonstrated improved efficacy compared with ipilimumab alone in the CheckMate 067 study. However, the combination resulted in a higher frequency of grade 3/4 adverse events (AEs), which could result in diminished health-related quality of life (HRQoL). Here we report analyses of HRQoL for patients with advanced melanoma in clinical trial CheckMate 067. Patients and methods HRQoL was assessed at weeks 1 and 5 per 6-week cycle for the first 6 months, once every 6 weeks thereafter, and at two follow-up visits using the European Organization for Research and Treatment of Care Core Quality of Life Questionnaire and the EuroQoL Five Dimensions Questionnaire. In addition to the randomised population, patient subgroups, including BRAF mutation status, partial or complete response, treatment-related AEs of grade 3/4, and those who discontinued due to any reason and due to an AE, were investigated. Results Nivolumab and ipilimumab combination and nivolumab alone both maintained HRQoL, and no clinically meaningful deterioration was observed over time compared with ipilimumab. In addition, similar results were observed across patient subgroups, and no clinically meaningful changes in HRQoL were observed during follow-up visits for patients who discontinued due to any cause. Conclusion These results further support the clinical benefit of nivolumab monotherapy and nivolumab and ipilimumab combination therapy in patients with advanced melanoma. The finding that the difference in grade 3/4 AEs between the arms did not translate into clinically meaningful differences in the reported HRQoL may be relevant in the clinical setting. Study number NCT01844505. PMID:28651159

  3. Patterns of attendance to health checks in a municipality setting: the Danish ‘Check Your Health Preventive Program’

    Directory of Open Access Journals (Sweden)

    Anne-Louise Bjerregaard

    2017-03-01

    More than half of a general population voluntarily attended a general health check, despite a resource intensive offer. People with low resources had lower attendance rates. This study adds a detailed description of mutually exclusive groups of attenders, for use in future planning and implementation of preventive actions.

  4. The antibody Hijikata Tatsumi

    Directory of Open Access Journals (Sweden)

    Éden Peretta

    2012-11-01

    Full Text Available Considered one of the most influential modern dance representatives in Japan, Tatsumi Hijikata’s work was a milestone in the Japanese post-war experimental artistic scene. Heretic son of his time, he staged a fertile mix of artistic and cultural influences, overlapping subversive elements of European arts and philosophy with radical references from pre-modern Japanese culture. In this way he built the foundations of its unstable antibody, its political-artistic project of dissolution of a organism, both physical and social.

  5. Check dams effects on sediment transport in steep slope flume

    Science.gov (United States)

    Piton, Guillaume; Recking, Alain

    2014-05-01

    Depending on many influences (geology, relief, hydrology, land use, etc.) some mountainous watershed are prone to cause casualties and facilities damages. Large amounts of sediments episodically released by torrents are often the biggest problem in torrent related hazard mitigation. Series of transversal structures as check dams and ground sills are often used in the panel of risk mitigation technics. A large literature exits on check dams and it mainly concerns engineering design, e.g. toe scouring, stability stress diagram, changes in upper and lower reaches equilibrium slopes. Check dams in steep slope rivers constitute fixed points in the bed profile and prevent general bed incision. However their influence on sediment transport once they are filled is not yet clear. Two flume test campaigns, synthetize in Table 1, were performed to investigate this question: Table 1 : experiment plan Run (duration) Ref1 (50h)CD1a (30h)CD1b (30h)Ref2 (92h)CD2 (18h) Solid feeding discharge (g.s^-1) 44 44 44 60 60 Number of check dams none 1 3 none 2 A nearly 5-m-long, 10-cm-wide and 12%-steep flume was used. The water discharge was set to 0,55 l/s in all runs. A mixture of poorly sorted natural sediments with diameters between 0.8 and 40 mm was used. An open solid-discharge-feeding circuit kept the inlet sediment flux constant during all experiments. As both feeding rates did not present variation, changes in outlet solid discharge were assumed to be due to bed variations in the bed storage. We observed strong fluctuations of solid flux and slope in each reaches of all runs between: (i) steep aggradating armoured bed and (ii) less steep and finer bed releasing bedload sheets during erosion events and inducing bedload pulses. All experiments showed consistent results: transported volume associated with erosion event decreased with the length between two subsequent check dams. Solid transversal structures shorten the upstream erosion-propagation and avoid downstream change in the

  6. Stove checking behaviour in people with OCD vs. anxious controls.

    Science.gov (United States)

    Bucarelli, Bianca; Purdon, Christine

    2016-12-01

    A growing body of research suggests that the repetition of an action degrades memory for that action, as well as confidence that is has been done correctly. This has important implications for understanding the compulsive repetition of actions characteristic of obsessive compulsive disorder (OCD). At this time, though, much of the research has been conducted on analogue or nonclinical OCD samples in comparison to healthy controls and often using virtual, as opposed to actual, threat stimuli. Furthermore, although it has been argued that people with OCD are overly attentive to threat stimuli, the research on actual attention to threat is scant. People with a principal diagnosis of OCD (n = 30) and people with a clinically significant diagnosis of an anxiety disorder, but no OCD (n = 18) completed measures of memory confidence and responsibility and then underwent a stove-checking task in a functioning kitchen while wearing a portable eye tracking device. Pre- and post-task ratings of harm and responsibility were taken, along with post-task ratings of memory and certainty. People with OCD did not exhibit poorer memory confidence than the anxious control (AC) group, but did report greater trait and state responsibility for harm. The OCD group checked longer than did the AC group and check duration predicted post-task ratings of harm, but to the same extent in both groups. People with OCD attended to threat items less than did the AC group. Greater visual attention to the stove during the checking period was associated with greater post-task ratings of responsibility and harm and with less certainty in and memory for the check - but only for the AC group. The sample size was modest, women were over-represented and problems with the eye tracking device reduced the amount of reliable data available for analysis. Compulsions are complex actions that are mediated by many trait, state and contextual factors. People with OCD may be able to circumvent self

  7. The future of monoclonal antibody technology

    OpenAIRE

    Zider, Alexander; Drakeman, Donald L

    2010-01-01

    With the rapid growth of monoclonal antibody-based products, new technologies have emerged for creating modified forms of antibodies, including fragments, conjugates and multi-specific antibodies. We created a database of 450 therapeutic antibodies in development to determine which technologies and indications will constitute the “next generation” of antibody products. We conclude that the antibodies of the future will closely resemble the antibodies that have already been approved for commer...

  8. Monoclonal antibodies for treating cancer

    International Nuclear Information System (INIS)

    Dillman, R.O.

    1989-01-01

    The purpose of this study is to assess the current status of in-vivo use of monoclonal antibodies for treating cancer. Publications appearing between 1980 and 1988 were identified by computer searches using MEDLINE and CANCERLIT, by reviewing the table of contents of recently published journals, and by searching bibliographies of identified books and articles. More than 700 articles, including peer-reviewed articles and book chapters, were identified and selected for analysis. The literature was reviewed and 235 articles were selected as relevant and representative of the current issues and future applications for in-vivo monoclonal antibodies for cancer therapy and of the toxicity and efficacy which has been associated with clinical trials. Approaches include using antibody alone (interacting with complement or effector cells or binding directly with certain cell receptors) and immunoconjugates (antibody coupled to radioisotopes, drugs, toxins, or other biologicals). Most experience has been with murine antibodies. Trials of antibody alone and radiolabeled antibodies have confirmed the feasibility of this approach and the in-vivo trafficking of antibodies to tumor cells. However, tumor cell heterogeneity, lack of cytotoxicity, and the development of human antimouse antibodies have limited clinical efficacy. Although the immunoconjugates are very promising, heterogeneity and the antimouse immune response have hampered this approach as has the additional challenge of chemically or genetically coupling antibody to cytotoxic agents. As a therapeutic modality, monoclonal antibodies are still promising but their general use will be delayed for several years. New approaches using human antibodies and reducing the human antiglobulin response should facilitate treatment. 235 references

  9. Perseveration causes automatization of checking behavior in obsessive-compulsive disorder.

    Science.gov (United States)

    Dek, Eliane C P; van den Hout, Marcel A; Engelhard, Iris M; Giele, Catharina L; Cath, Danielle C

    2015-08-01

    Repeated checking leads to reductions in meta-memory (i.e., memory confidence, vividness and detail), and automatization of checking behavior (Dek, van den Hout, Giele, & Engelhard, 2014, 2015). Dek et al. (2014) suggested that this is caused by increased familiarity with the checked stimuli. They predicted that defamiliarization of checking by modifying the perceptual characteristics of stimuli would cause de-automatization and attenuate the negative meta-memory effects of re-checking. However, their results were inconclusive. The present study investigated whether repeated checking leads to automatization of checking behavior, and if defamiliarization indeed leads to de-automatization and attenuation of meta-memory effects in patients with OCD and healthy controls. Participants performed a checking task, in which they activated, deactivated and checked threat-irrelevant stimuli. During a pre- and post-test checking trial, check duration was recorded and a reaction time task was simultaneously administered as dual-task to assess automatization. After the pre- and post-test checking trial, meta-memory was rated. Results showed that relevant checking led to automatization of checking behavior on the RT measure, and negative meta-memory effects for patients and controls. Defamiliarization led to de-automatization measured with the RT task, but did not attenuate the negative meta-memory effects of repeated checking. Clinical implications are discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. 12 CFR Appendix C to Part 229 - Model Availability Policy Disclosures, Clauses, and Notices; Model Substitute Check Policy...

    Science.gov (United States)

    2010-01-01

    ... OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Pt. 229, App. C Appendix C to Part 229—Model... Checks and Your Rights— Substitute Checks and Your Rights What Is a Substitute Check? To make check... rights under other law with respect to those transactions. What Are My Rights Regarding Substitute Checks...

  11. Tabhu: tools for antibody humanization

    DEFF Research Database (Denmark)

    Olimpieri, Pier Paolo; Marcatili, Paolo; Tramontano, Anna

    2015-01-01

    and time-consuming experiments. Here we present tools for antibody humanization (Tabhu) a web server for antibody humanization. Tabhu includes tools for human template selection, grafting, back-mutation evaluation, antibody modelling and structural analysis, helping the user in all the critical steps...... elicit unwanted and dangerous immunogenic responses. Antibody humanization methods are designed to produce molecules with a better safety profile still maintaining their ability to bind the antigen. This can be accomplished by grafting the non-human regions determining the antigen specificity...... of the humanization experiment protocol....

  12. Optimisation of BPMN Business Models via Model Checking

    DEFF Research Database (Denmark)

    Herbert, Luke Thomas; Sharp, Robin

    2013-01-01

    We present a framework for the optimisation of business processes modelled in the business process modelling language BPMN, which builds upon earlier work, where we developed a model checking based method for the analysis of BPMN models. We define a structure for expressing optimisation goals...... for synthesized BPMN components, based on probabilistic computation tree logic and real-valued reward structures of the BPMN model, allowing for the specification of complex quantitative goals. We here present a simple algorithm, inspired by concepts from evolutionary algorithms, which iteratively generates...... candidate improved processes based on the fittest of the previous generation. The evaluation of the fitness of each candidate in a generation is performed via model checking, detailed in previous work. At each iteration, this allows the determination of the precise numerical evaluation of the performance...

  13. Reliability estimation for check valves and other components

    International Nuclear Information System (INIS)

    McElhaney, K.L.; Staunton, R.H.

    1996-01-01

    For years the nuclear industry has depended upon component operational reliability information compiled from reliability handbooks and other generic sources as well as private databases generated by recognized experts both within and outside the nuclear industry. Regrettably, these technical bases lacked the benefit of large-scale operational data and comprehensive data verification, and did not take into account the parameters and combinations of parameters that affect the determination of failure rates. This paper briefly examines the historic use of generic component reliability data, its sources, and its limitations. The concept of using a single failure rate for a particular component type is also examined. Particular emphasis is placed on check valves due to the information available on those components. The Appendix presents some of the results of the extensive analyses done by Oak Ridge National Laboratory (ORNL) on check valve performance

  14. Recent research on the pharmaceutical checking of radioelements (1961)

    International Nuclear Information System (INIS)

    Cohen, Y.; Ingrand, J.

    1960-01-01

    Checking on radioactive preparations for medical use is complicated by difficulties due to the radioactivity, the instability and the methods of using these solutions. In effect it is necessary, in order to draw up a practicable set of rules governing such checks, to know both the method of preparation and the properties of the radioelement, as well as special and often contradictory features of its use. These tests fall into three categories: physical, chemical and biological. Preparations of chromium 51, iron 59 and arsenic 76 have been dealt with in recent studies. In each case special tests were necessary, and these will be described in this paper. The practice of these tests is of twofold interest: firstly they provide a maximum guarantee to the user, and secondly they guide the chemist in his manipulations, immediately and thoroughly. (author) [fr

  15. Asymptomatic brain tumor detected at brain check-up

    Energy Technology Data Exchange (ETDEWEB)

    Onizuka, Masanari; Suyama, Kazuhiko; Shibayama, Akira; Hiura, Tsuyoshi; Horie, Nobutaka; Miyazaki, Hisaya [Sankoukai Miyazaki Hospital, Isahaya, Nagasaki (Japan)

    2001-09-01

    Brain check-up was performed in 4000 healthy subjects who underwent medical and radiological examinations for possible brain diseases in our hospital from April 1996 to March 2000. Magnetic resonance imaging revealed 11 brain tumors which consisted of six meningiomas, three pituitary adenomas, one astrocytoma, and one epidermoid cyst. The detection rate of incidental brain tumor in our hospital was 0.3%. Nine patients underwent surgery, with one case of morbidity due to postoperative transient oculomotor nerve paresis. The widespread use of brain check-up may increasingly detect asymptomatic brain tumors. Surgical indications for such lesions remain unclear, and the strategy for treatment should be determined with consideration of the patient's wishes. (author)

  16. Technology of irradiation processing for checking garlic sprouting

    International Nuclear Information System (INIS)

    Chen Yuntang

    1999-01-01

    Study on technology of irradiation processing for checking garlic sprouting was carried out. The results are as follows. 1. the suitable irradiation time of garlic could be prolonged when the garlic was preserved at low temperature (-2 +- 1 degree C). When the garlic was stored till the end of the year and then irradiated, the sprouting could be checked effectively. When the garlic was stored till the next March, the effect of sprouting inhibition decreased; 2. When garlic was irradiated at suitable time and then subsequently stored at low temperature, the effect of sprouting inhibition was the same as that with cold storage before irradiation. However, if the cold storage period was rather long, the effect was not as good as that with cold storage after irradiation; 3. Browning of irradiated garlic did not occur when the garlic was preserved at low temperature (-2 +- 1 degree C), indicating that the browning of sprout and bud was caused by higher storage temperature

  17. Rejuvinasi Sistem Checks and Balances Dalam Sistem Ketatanegaraan di Indonesia

    Directory of Open Access Journals (Sweden)

    Indra Rahmatullah

    2016-04-01

    Full Text Available Rejuvenation of Check and Balance System in Statehood System in Indonesia. Instead of delegated to only a person or an Institution, State Sovereignty shall be divided into some Institutions (separation of power.  The concept of Separation of power is difficult to be implemented because the each State Institution cannot share their power, therefore the concept of distribution of power has been introduced as alternative. This concept recognise Check and balances system. However, It will not guarantee harmony between State Institution. It exist the tension between State Institutions because They feel having the same authority, as seen in some cases such as between Parliament and president on Bill of  head of regional election, Police Department and Commission of Eradication Corruption and the latest is the conflict between Supreme Court and Judicial Commission. DOI: 10.15408/jch.v1i2.2992

  18. Mixed Portmanteau Test for Diagnostic Checking of Time Series Models

    Directory of Open Access Journals (Sweden)

    Sohail Chand

    2014-01-01

    Full Text Available Model criticism is an important stage of model building and thus goodness of fit tests provides a set of tools for diagnostic checking of the fitted model. Several tests are suggested in literature for diagnostic checking. These tests use autocorrelation or partial autocorrelation in the residuals to criticize the adequacy of fitted model. The main idea underlying these portmanteau tests is to identify if there is any dependence structure which is yet unexplained by the fitted model. In this paper, we suggest mixed portmanteau tests based on autocorrelation and partial autocorrelation functions of the residuals. We derived the asymptotic distribution of the mixture test and studied its size and power using Monte Carlo simulations.

  19. Asymptomatic brain tumor detected at brain check-up

    International Nuclear Information System (INIS)

    Onizuka, Masanari; Suyama, Kazuhiko; Shibayama, Akira; Hiura, Tsuyoshi; Horie, Nobutaka; Miyazaki, Hisaya

    2001-01-01

    Brain check-up was performed in 4000 healthy subjects who underwent medical and radiological examinations for possible brain diseases in our hospital from April 1996 to March 2000. Magnetic resonance imaging revealed 11 brain tumors which consisted of six meningiomas, three pituitary adenomas, one astrocytoma, and one epidermoid cyst. The detection rate of incidental brain tumor in our hospital was 0.3%. Nine patients underwent surgery, with one case of morbidity due to postoperative transient oculomotor nerve paresis. The widespread use of brain check-up may increasingly detect asymptomatic brain tumors. Surgical indications for such lesions remain unclear, and the strategy for treatment should be determined with consideration of the patient's wishes. (author)

  20. Optimization analysis of swing check valve closing induced water hammer

    International Nuclear Information System (INIS)

    Han Wenwei; Han Weishi; Guo Qing; Wang Xin; Liu Chunyu

    2014-01-01

    A mathematical-physics model of double pump parallel feed system was constructed. The water hammer was precisely calculated, which was formed in the closing process of swing check valve. And a systematic analysis was carried out to determine the influence of the torques from both valve plate and damping torsion spring on the valve closing induced water hammer. The results show that the swing check valve would distinctly produce the water hammer during the closing procedure in the double pump parallel feed water system. The torques of the valve plate can partly reduce the water hammer effect, and implying appropriate materials of valve plate and appropriate spring can effectively relieve the harm of water hammer. (authors)

  1. Changes to criminal records checks used to safeguard vulnerable patients.

    Science.gov (United States)

    Griffith, Richard; Tengnah, Cassam

    2012-07-01

    The Protection of Freedoms Act 2012 is introducing changes to the Criminal Records Bureau (CRB) checks carried out on those people who work with vulnerable groups. The new law is the coalition Government's response to the criticism of the Safeguarding Vulnerable Group Act 2006. It will merge the CRB and Independent Safeguarding Authority into a new Disclosure and Barring Service and will enhance the rights of applicants to challenge the CRB's right to disclose non-conviction information as part of an enhanced criminal records check. In the first of two articles on the Protection of Freedoms Act 2012, Richard Griffith and Cassam Tengnah discuss the current framework for disclosing criminal records and the impact of the changes on district nurses applying for new posts.

  2. Analysis of DIRAC's behavior using model checking with process algebra

    CERN Document Server

    Remenska, Daniela; Willemse, Tim; Bal, Henri; Verstoep, Kees; Fokkink, Wan; Charpentier, Philippe; Diaz, Ricardo Graciani; Lanciotti, Elisa; Roiser, Stefan; Ciba, Krzysztof

    2012-01-01

    DIRAC is the grid solution developed to support LHCb production activities as well as user data analysis. It consists of distributed services and agents delivering the workload to the grid resources. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check and possibly react to changes in the system state. Each agent's logic is relatively simple, the main complexity lies in their cooperation. Agents run concurrently, and collaborate using the databases as shared memory. The databases can be accessed directly by the agents if running locally or through a DIRAC service interface if necessary. This shared-memory model causes entities to occasionally get into inconsistent states. Tracing and fixing such problems becomes formidable due to the inherent parallelism present. We propose more rigorous methods to cope with this. Model checking is one such technique for analysis of an abstract model of a system. Unlike con...

  3. Independence-Based Optimization of Epistemic Model Checking

    Science.gov (United States)

    2017-02-22

    imperfect information of their environment. It has been applied to settings that include diagnosis [8], and reasoning in game - like settings [15, 16, 32...represents the model as a concurrent pro- gram, in which each of the agents executes a protocol in the context of an environment. We provide a symbolic ...handled by the symbolic model checking algorithms. The paper presents experimental results that demonstrate that the condi- tional independence

  4. The impact of climate change on obsessive compulsive checking concerns.

    Science.gov (United States)

    Jones, Mairwen K; Wootton, Bethany M; Vaccaro, Lisa D; Menzies, Ross G

    2012-03-01

    To investigate whether climate change has impacted on the nature of the obsessions or compulsions experienced by patients with obsessive compulsive disorder (OCD). The sample comprised 50 patients with OCD checking subtype who had presented at the Anxiety Disorders Clinic at The University of Sydney seeking treatment during the period March 2008 to November 2009. Details of the type of obsessions and compulsions directly related to climate change phenomena were identified. Fourteen of the 50 participants (28%) were identified as having OCD concerns directly related to climate change. The most frequent concerns involved electricity, water and gas wastage. Less frequent concerns included pets dying of thirst and one participant was concerned about house damage due to floors cracking, pipes leaking; roof problems and white ant activity. Compulsions included checking and rechecking pet water bowls, light switches, taps, stoves, skirting boards, pipes, roofs and wooden structures. While these behaviours are not particularly unusual for people with this condition, it was the rationale they provided for carrying them out that was surprising. Instead of checking and rechecking so as to prevent fire or flood, the rituals were specifically performed so as to reduce their global footprint, or respond to climate change-induced negative events. Our findings demonstrate that the types of obsessions and compulsions experienced by 28% of our sample were directly aligned with the current issue of climate change and the perceived dangers associated with this phenomenon. To our knowledge this represents the first documentation of the significant impact of climate change on the nature of the concerns experienced by people with OCD checking subtype. We suggest that mental health professionals need to be aware of, and assess for the presence of such concerns.

  5. Model Checking for Energy Efficient Scheduling in Wireless Sensor Networks

    OpenAIRE

    Schmitt, Peter H.; Werner, Frank

    2006-01-01

    Networking and power management of wireless energy - conscious sensor networks is an important area of current research. We investigate a network of MicaZ sensor motes using the ZigBee protocol for communication, and provide a model using Timed Safety Automata. Our analysis focuses on estimating energy consumption by model checking in different scenarios using the Uppaal tool. Special interest is devoted to the energy use in margi...

  6. Bayesian inference with information content model check for Langevin equations

    DEFF Research Database (Denmark)

    Krog, Jens F. C.; Lomholt, Michael Andersen

    2017-01-01

    The Bayesian data analysis framework has been proven to be a systematic and effective method of parameter inference and model selection for stochastic processes. In this work we introduce an information content model check which may serve as a goodness-of-fit, like the chi-square procedure......, to complement conventional Bayesian analysis. We demonstrate this extended Bayesian framework on a system of Langevin equations, where coordinate dependent mobilities and measurement noise hinder the normal mean squared displacement approach....

  7. Logic Model Checking of Unintended Acceleration Claims in Toyota Vehicles

    Science.gov (United States)

    Gamble, Ed

    2012-01-01

    Part of the US Department of Transportation investigation of Toyota sudden unintended acceleration (SUA) involved analysis of the throttle control software, JPL Laboratory for Reliable Software applied several techniques including static analysis and logic model checking, to the software; A handful of logic models were build, Some weaknesses were identified; however, no cause for SUA was found; The full NASA report includes numerous other analyses

  8. Model Checking for Licensing Support in the Finnish Nuclear Industry

    Energy Technology Data Exchange (ETDEWEB)

    Antti, Pakonen; Janne, Valkonen [VTT Technical Research, VTT (Finland); Sami, Matinaho; Markus, Hartikainen [Protum Power and Heat, Fortum (Finland)

    2014-08-15

    This paper examines how model checking can be used to support the qualification of digital I and C software in nuclear power plants, in a way that is consistent with regulatory demands specifically, the common position of seven European nuclear regulators and authorised technical support organisations. As a practical example, we discuss the third-party review service provided by VTT for the power company Fortum in the I and C renewal project of the Loviisa plant in southern Finland.

  9. GramCheck: A Grammar and Style Checker

    OpenAIRE

    Bustamante, Flora Ramírez; León, Fernando Sánchez

    1996-01-01

    This paper presents a grammar and style checker demonstrator for Spanish and Greek native writers developed within the project GramCheck. Besides a brief grammar error typology for Spanish, a linguistically motivated approach to detection and diagnosis is presented, based on the generalized use of PROLOG extensions to highly typed unification-based grammars. The demonstrator, currently including full coverage for agreement errors and certain head-argument relation issues, also provides correc...

  10. Approximating Attractors of Boolean Networks by Iterative CTL Model Checking.

    Science.gov (United States)

    Klarner, Hannes; Siebert, Heike

    2015-01-01

    This paper introduces the notion of approximating asynchronous attractors of Boolean networks by minimal trap spaces. We define three criteria for determining the quality of an approximation: "faithfulness" which requires that the oscillating variables of all attractors in a trap space correspond to their dimensions, "univocality" which requires that there is a unique attractor in each trap space, and "completeness" which requires that there are no attractors outside of a given set of trap spaces. Each is a reachability property for which we give equivalent model checking queries. Whereas faithfulness and univocality can be decided by model checking the corresponding subnetworks, the naive query for completeness must be evaluated on the full state space. Our main result is an alternative approach which is based on the iterative refinement of an initially poor approximation. The algorithm detects so-called autonomous sets in the interaction graph, variables that contain all their regulators, and considers their intersection and extension in order to perform model checking on the smallest possible state spaces. A benchmark, in which we apply the algorithm to 18 published Boolean networks, is given. In each case, the minimal trap spaces are faithful, univocal, and complete, which suggests that they are in general good approximations for the asymptotics of Boolean networks.

  11. Effects of monetary reward and punishment on information checking behaviour.

    Science.gov (United States)

    Li, Simon Y W; Cox, Anna L; Or, Calvin; Blandford, Ann

    2016-03-01

    Two experiments were conducted to examine whether checking one's own work can be motivated by monetary reward and punishment. Participants were randomly assigned to one of three conditions: a flat-rate payment for completing the task (Control); payment increased for error-free performance (Reward); payment decreased for error performance (Punishment). Experiment 1 (N = 90) was conducted with liberal arts students, using a general data-entry task. Experiment 2 (N = 90) replicated Experiment 1 with clinical students and a safety-critical 'cover story' for the task. In both studies, Reward and Punishment resulted in significantly fewer errors, more frequent and longer checking, than Control. No such differences were obtained between the Reward and Punishment conditions. It is concluded that error consequences in terms of monetary reward and punishment can result in more accurate task performance and more rigorous checking behaviour than errors without consequences. However, whether punishment is more effective than reward, or vice versa, remains inconclusive. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  12. Approximating attractors of Boolean networks by iterative CTL model checking

    Directory of Open Access Journals (Sweden)

    Hannes eKlarner

    2015-09-01

    Full Text Available This paper introduces the notion of approximating asynchronous attractors of Boolean networks by minimal trap spaces. We define three criteria for determining the quality of an approximation: faithfulness which requires that the oscillating variables of all attractors in a trapspace correspond to their dimensions, univocality which requires that there is a unique attractor in each trap space and completeness which requires that there are no attractors outside of a given set of trap spaces. Each is a reachability property for which we give equivalent model checking queries. Whereas faithfulness and univocality can be decided by model checking the corresponding subnetworks, the naive query for completeness must be evaluated on the full state space. Our main result is an alternative approach which is based on the iterative refinement of an initially poor approximation. The algorithm detects so-called autonomous sets in the interaction graph, variables that contain all their regulators, and considers their intersection and extension in order to perform model checking on the smallest possible state spaces. A benchmark, in which we apply the algorithm to 18 published Boolean networks, is given. In each case, the minimal trap spaces are faithful, univocal and complete which suggests that they are in general good approximations for the asymptotics of Boolean networks.

  13. Assembly-line health check up in digitalized hospital.

    Science.gov (United States)

    Liu, Yalan; Yao, Bin; Zhang, Zigang

    2002-01-01

    The health check up flow of digital hospital can be consulted with the assembly line of industry factory. Because they have the following same features: highly specialized workstation, closeness and continuance, rhythm, balanced production, continuous production. The essential prerequisites are as the follows: The inspecting items and methods should be stable; advanced product mix and stable production design; standardized raw material, consumption, procedure, inspection method; there are lots of request for health inspection; the customers move at the least unit; the space arrangement should be reasonable; the time arrangement should be proportion. With the computer net, the digital inspection can achieves the raw material controlling accurately. The basis of check up line concerns about equipment, net and software, data collection, and personnel. The group technology is used in the health inspection flow design of the digital hospital in the field of items customers and zone redivided. The digital assembly linemic health inspect has the following stages: member registering, notice, check in, arrange order, time control, report, feedback and analysis. The assembly linemic has following advantages: increasing the productivity, the space utility, satisfaction of customer, fund returning, lowering the cost and ensuring the quality.

  14. Theranostics Using Antibodies and Antibody-Related Therapeutics

    NARCIS (Netherlands)

    Moek, Kirsten L; Giesen, Danique; Kok, Iris C; de Groot, Derk Jan A; Jalving, Mathilde; Fehrmann, Rudolf S N; Lub-de Hooge, Marjolijn N; Brouwers, Adrienne H; de Vries, Elisabeth G E

    In theranostics, radiolabeled compounds are used to determine a treatment strategy by combining therapeutics and diagnostics in the same agent. Monoclonal antibodies (mAbs) and antibody-related therapeutics represent a rapidly expanding group of cancer medicines. Theranostic approaches using these

  15. Energy reduction through voltage scaling and lightweight checking

    Science.gov (United States)

    Kadric, Edin

    As the semiconductor roadmap reaches smaller feature sizes and the end of Dennard Scaling, design goals change, and managing the power envelope often dominates delay minimization. Voltage scaling remains a powerful tool to reduce energy. We find that it results in about 60% geomean energy reduction on top of other common low-energy optimizations with 22nm CMOS technology. However, when voltage is reduced, it becomes easier for noise and particle strikes to upset a node, potentially causing Silent Data Corruption (SDC). The 60% energy reduction, therefore, comes with a significant drop in reliability. Duplication with checking and triple-modular redundancy are traditional approaches used to combat transient errors, but spending 2--3x the energy for redundant computation can diminish or reverse the benefits of voltage scaling. As an alternative, we explore the opportunity to use checking operations that are cheaper than the base computation they are guarding. We devise a classification system for applications and their lightweight checking characteristics. In particular, we identify and evaluate the effectiveness of lightweight checks in a broad set of common tasks in scientific computing and signal processing. We find that the lightweight checks cost only a fraction of the base computation (0-25%) and allow us to recover the reliability losses from voltage scaling. Overall, we show about 50% net energy reduction without compromising reliability compared to operation at the nominal voltage. We use FPGAs (Field-Programmable Gate Arrays) in our work, although the same ideas can be applied to different systems. On top of voltage scaling, we explore other common low-energy techniques for FPGAs: transmission gates, gate boosting, power gating, low-leakage (high-Vth) processes, and dual-V dd architectures. We do not scale voltage for memories, so lower voltages help us reduce logic and interconnect energy, but not memory energy. At lower voltages, memories become dominant

  16. Genotyping of KRAS Mutational Status by the In-Check Lab-on-Chip Platform.

    Science.gov (United States)

    Guarnaccia, Maria; Iemmolo, Rosario; San Biagio, Floriana; Alessi, Enrico; Cavallaro, Sebastiano

    2018-01-05

    The KRAS oncogene is involved in the pathogenesis of several types of cancer, particularly colorectal cancer (CRC). The most frequent mutations in this gene are associated with poor survival, increased tumor aggressiveness and resistance to therapy with anti-epidermal growth factor receptor (EGFR) antibodies. For this reason, KRAS mutation testing has become increasingly common in clinical practice for personalized cancer treatments of CRC patients. Detection methods for KRAS mutations are currently expensive, laborious, time-consuming and often lack of diagnostic sensitivity and specificity. In this study, we describe the development of a Lab-on-Chip assay for genotyping of KRAS mutational status. This assay, based on the In-Check platform, integrates microfluidic handling, a multiplex polymerase chain reaction (PCR) and a low-density microarray. This integrated sample-to-result system enables the detection of KRAS point mutations, including those occurring in codons 12 and 13 of exon 2, 59 and 61 of exon 3, 117 and 146 of exon 4. Thanks to its miniaturization, automation, rapid analysis, minimal risk of sample contamination, increased accuracy and reproducibility of results, this Lab-on-Chip platform may offer immediate opportunities to simplify KRAS genotyping into clinical routine.

  17. Genotyping of KRAS Mutational Status by the In-Check Lab-on-Chip Platform

    Directory of Open Access Journals (Sweden)

    Maria Guarnaccia

    2018-01-01

    Full Text Available The KRAS oncogene is involved in the pathogenesis of several types of cancer, particularly colorectal cancer (CRC. The most frequent mutations in this gene are associated with poor survival, increased tumor aggressiveness and resistance to therapy with anti-epidermal growth factor receptor (EGFR antibodies. For this reason, KRAS mutation testing has become increasingly common in clinical practice for personalized cancer treatments of CRC patients. Detection methods for KRAS mutations are currently expensive, laborious, time-consuming and often lack of diagnostic sensitivity and specificity. In this study, we describe the development of a Lab-on-Chip assay for genotyping of KRAS mutational status. This assay, based on the In-Check platform, integrates microfluidic handling, a multiplex polymerase chain reaction (PCR and a low-density microarray. This integrated sample-to-result system enables the detection of KRAS point mutations, including those occurring in codons 12 and 13 of exon 2, 59 and 61 of exon 3, 117 and 146 of exon 4. Thanks to its miniaturization, automation, rapid analysis, minimal risk of sample contamination, increased accuracy and reproducibility of results, this Lab-on-Chip platform may offer immediate opportunities to simplify KRAS genotyping into clinical routine.

  18. Antibodies and Plasmodium falciparum merozoites

    NARCIS (Netherlands)

    Ramasamy, R; Ramasamy, M; Yasawardena, S

    There is considerable interest in using merozoite proteins in a vaccine against falciparum malaria. Observations that antibodies to merozoite surface proteins block invasion are a basis for optimism. This article draws attention to important and varied aspects of how antibodies to Plasmodium

  19. Catalytic Antibodies: Concept and Promise

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 11. Catalytic Antibodies: Concept and Promise. Desirazu N Rao Bharath Wootla. General Article Volume 12 Issue ... Keywords. Catalytic antibodies; abzymes; hybridome technology; Diels– Alder reaction; Michaelis– Menten kinetics; Factor VIII.

  20. Antiphospholipid antibodies: standardization and testing.

    Science.gov (United States)

    Riley, R S; Friedline, J; Rogers, J S

    1997-09-01

    A phenomenon originally scorned as a laboratory nuisance has turned out to be an important cause of thromboembolism, fetal death, and other forms of human disease. Investigations of this inaptly named "lupus anticoagulant" has led to the discovery of at least two distinct types of autoimmune antibodies. In spite of recent discoveries regarding the pathophysiology of these antibodies, their clinical significance is still controversial.

  1. Educational paper: Primary antibody deficiencies

    NARCIS (Netherlands)

    G.J.A. Driessen (Gertjan); M. van der Burg (Mirjam)

    2011-01-01

    textabstractPrimary antibody deficiencies (PADs) are the most common primary immunodeficiencies and are characterized by a defect in the production of normal amounts of antigen-specific antibodies. PADs represent a heterogeneous spectrum of conditions, ranging from often asymptomatic selective IgA

  2. [Antibody induction after intrauterine interventions].

    Science.gov (United States)

    Hoch, J; Giers, G; Bald, R; Hansmann, M; Hanfland, P

    1993-06-01

    Immunohematologic and clinical data, i.e., antibody profile, location of the placenta, mode of cordocentesis, obtained from 48 pregnant patients with irregular erythrocyte antibodies during the last 2 years have been retrospectively evaluated. All fetuses of the patients received intrauterine transfusions for the treatment of fetal erythroblastosis. In 16 (33%) patients (group I) a secondarily induced antibody was detected after the onset of intrauterine transfusion therapy. 32 (67%) patients (group II) did not further develop new antibody specificities. Group I exhibited a significantly different distribution in the location of the placenta (p pregnant women. In group I a 5-fold higher rate of anterior than posterior placenta location was found. The mode of cordocentesis differed significantly (p antibodies by invasive intrauterine interventions in our patients depended indirectly on the location of the placenta and directly on the mode of the puncture (trans- vs. paraplacental access).

  3. Slit-check dams for the control of debris flow

    Science.gov (United States)

    Armanini, Aronne; Larcher, Michele

    2017-04-01

    Debris flows are paroxysmal events that mobilize, alongside water, huge quantities of sediment in a very short time, then with both solid and liquid huge discharges, possibly exceeding the capacity of the current torrent restoration works. In this respect, the climate change forcing cannot be ignored. In the majority of urbanized areas, that are generally the most vulnerable, there is often not enough space to create channelling works able to let the volumes pass through without overflowing. The simplest, less expensive and most sustainable solution consists in reducing the peak solid discharge by creating storage areas upstream of the settlements, typically upstream of the alluvial fans, allowing for reduced works of canalization, that are compatible with the constraints imposed by the urbanization. The general idea consists in storing a part of the flowing solids during the peak of the hydrograph and releasing it in a successive phase or during minor floods. For this purpose, and in order to optimize the solid peak discharge reduction, it is necessary that properly designed open-check dams, capable of inducing a significative sedimentation of the solid discharge only when this exceeds a design-threshold value, control the deposition basins. A correct design of the check dam is crucial in order to induce the sedimentation in the right amount and at the right moment: a too early sedimentation might fill the volume before the peak, like in the case of close-check dams, while a too weak sedimentation might not use the whole available volume. In both cases, the channelling works might not be sufficient to let all the flow pass through, compromising the safety of the settlement. To avoid this inconvenience, we propose the use of slit-check dams, whose efficiency has already been proved for bed load. Check dams are often designed only on the base of the designer's experience. Besides, even today it is often believed that the filtering effect of open check dams is

  4. Mobile Attendance Checking System on Android Platform for Kazakhstani University

    Science.gov (United States)

    Saparkhojayev, N.; Shakhov, E.; Mailybayev, Y.

    2016-04-01

    In the 21st century-the century of Information Technology, it is difficult to imagine life without any gadgets: phones, tablets, computers, laptops, and so on. Today, smartphones and tablets are becoming popular, and thus their operating systems become popular too. Android is designed for low-power devices that run on battery power at full capacity, using all of its services, such as cameras, lights, GPS navigation, Wi-Fi, etc. In Kazakhstani universities, the process of checking students’ attendance is one of the important issues, because final grade evaluation of students is based on their total number of appearances and their grades during the whole semester. This raises the question of having some tool to control students’ attendance. There are many possible ways of controlling attendance: there are many examples when universities prefer to control attendance by the use of paper sheet, and some universities prefer to use two-stage way of controlling attendance: firstly, teachers and professors use paper sheet for checking students’ attendance and after this, they fill out these information into a system manually. However, this is not an efficient way since there will be spent much of time for calling students names and putting marks like “presence” or “absence” if the class is a lecture class, and in this class at least 5 groups are presented. Furthermore, some students may call his/her friend as “presence” nevertheless to the fact that this student is currently absent. After taking into consideration all these issues and the fact that many gadgets use Android platform, authors of the following research paper decided to create a mobile system that makes easier to check students’ attendance automatically, and this system is implemented in Almaty Management University, Kazakhstan. The system is based on Android platform, and in this paper, details of this system are presented.

  5. Provenance based data integrity checking and verification in cloud environments.

    Science.gov (United States)

    Imran, Muhammad; Hlavacs, Helmut; Haq, Inam Ul; Jan, Bilal; Khan, Fakhri Alam; Ahmad, Awais

    2017-01-01

    Cloud computing is a recent tendency in IT that moves computing and data away from desktop and hand-held devices into large scale processing hubs and data centers respectively. It has been proposed as an effective solution for data outsourcing and on demand computing to control the rising cost of IT setups and management in enterprises. However, with Cloud platforms user's data is moved into remotely located storages such that users lose control over their data. This unique feature of the Cloud is facing many security and privacy challenges which need to be clearly understood and resolved. One of the important concerns that needs to be addressed is to provide the proof of data integrity, i.e., correctness of the user's data stored in the Cloud storage. The data in Clouds is physically not accessible to the users. Therefore, a mechanism is required where users can check if the integrity of their valuable data is maintained or compromised. For this purpose some methods are proposed like mirroring, checksumming and using third party auditors amongst others. However, these methods use extra storage space by maintaining multiple copies of data or the presence of a third party verifier is required. In this paper, we address the problem of proving data integrity in Cloud computing by proposing a scheme through which users are able to check the integrity of their data stored in Clouds. In addition, users can track the violation of data integrity if occurred. For this purpose, we utilize a relatively new concept in the Cloud computing called "Data Provenance". Our scheme is capable to reduce the need of any third party services, additional hardware support and the replication of data items on client side for integrity checking.

  6. Provenance based data integrity checking and verification in cloud environments.

    Directory of Open Access Journals (Sweden)

    Muhammad Imran

    Full Text Available Cloud computing is a recent tendency in IT that moves computing and data away from desktop and hand-held devices into large scale processing hubs and data centers respectively. It has been proposed as an effective solution for data outsourcing and on demand computing to control the rising cost of IT setups and management in enterprises. However, with Cloud platforms user's data is moved into remotely located storages such that users lose control over their data. This unique feature of the Cloud is facing many security and privacy challenges which need to be clearly understood and resolved. One of the important concerns that needs to be addressed is to provide the proof of data integrity, i.e., correctness of the user's data stored in the Cloud storage. The data in Clouds is physically not accessible to the users. Therefore, a mechanism is required where users can check if the integrity of their valuable data is maintained or compromised. For this purpose some methods are proposed like mirroring, checksumming and using third party auditors amongst others. However, these methods use extra storage space by maintaining multiple copies of data or the presence of a third party verifier is required. In this paper, we address the problem of proving data integrity in Cloud computing by proposing a scheme through which users are able to check the integrity of their data stored in Clouds. In addition, users can track the violation of data integrity if occurred. For this purpose, we utilize a relatively new concept in the Cloud computing called "Data Provenance". Our scheme is capable to reduce the need of any third party services, additional hardware support and the replication of data items on client side for integrity checking.

  7. Symbolic Game Semantics for Model Checking Program Families

    DEFF Research Database (Denmark)

    Dimovski, Aleksandar

    2016-01-01

    . In this paper, we propose an efficient game semantics based approach for verifying open program families, i.e. program families with free (undefined) identifiers. We use symbolic representation of algorithmic game semantics, where concrete values are replaced with symbolic ones. In this way, we can compactly...... represent program families with infinite integers as so-called (finite-state) featured symbolic automata. Specifically designed model checking algorithms are then employed to verify safety of all programs from a family at once and pinpoint those programs that are unsafe (respectively, safe). We present...

  8. Introduction of Virtualization Technology to Multi-Process Model Checking

    Science.gov (United States)

    Leungwattanakit, Watcharin; Artho, Cyrille; Hagiya, Masami; Tanabe, Yoshinori; Yamamoto, Mitsuharu

    2009-01-01

    Model checkers find failures in software by exploring every possible execution schedule. Java PathFinder (JPF), a Java model checker, has been extended recently to cover networked applications by caching data transferred in a communication channel. A target process is executed by JPF, whereas its peer process runs on a regular virtual machine outside. However, non-deterministic target programs may produce different output data in each schedule, causing the cache to restart the peer process to handle the different set of data. Virtualization tools could help us restore previous states of peers, eliminating peer restart. This paper proposes the application of virtualization technology to networked model checking, concentrating on JPF.

  9. Optimizing ZigBee Security using Stochastic Model Checking

    DEFF Research Database (Denmark)

    Yuksel, Ender; Nielson, Hanne Riis; Nielson, Flemming

    ZigBee is a fairly new but promising wireless sensor network standard that offers the advantages of simple and low resource communication. Nevertheless, security is of great concern to ZigBee, and enhancements are prescribed in the latest ZigBee specication: ZigBee-2007. In this technical report......, we identify an important gap in the specification on key updates, and present a methodology for determining optimal key update policies and security parameters. We exploit the stochastic model checking approach using the probabilistic model checker PRISM, and assess the security needs for realistic...

  10. Daily check of the electron beams with a diode system

    Energy Technology Data Exchange (ETDEWEB)

    Pilette, P. [Hospital Civil de Charleroi (Belgium). Centre for Radiotherapy

    1995-12-01

    A fast systems to check all the accelerator beams on a daily basis has been developed. A cheap home-made detector, based on non-medical diodes (type 1N5408), has been used since July 1992 to verify all the electron beams every day. The relative energy and Top-cGy correspondence is verified with one single irradiation of less than 1 minute by 6 diodes fixed in a polystyrene phantom. The principle of construction, software implementation and results are presented.

  11. Defect Detection: Combining Bounded Model Checking and Code Contracts

    Directory of Open Access Journals (Sweden)

    Marat Akhin

    2013-01-01

    Full Text Available Bounded model checking (BMC of C/C++ programs is a matter of scientific enquiry that attracts great attention in the last few years. In this paper, we present our approach to this problem. It is based on combining several recent results in BMC, namely, the use of LLVM as a baseline for model generation, employment of high-performance Z3 SMT solver to do the formula heavy-lifting, and the use of various function summaries to improve analysis efficiency and expressive power. We have implemented a basic prototype; experiment results on a set of simple test BMC problems are satisfactory.  

  12. Model Checking Geographically Distributed Interlocking Systems Using UMC

    DEFF Research Database (Denmark)

    Fantechi, Alessandro; Haxthausen, Anne Elisabeth; Nielsen, Michel Bøje Randahl

    2017-01-01

    The current trend of distributing computations over a network is here, as a novelty, applied to a safety critical system, namely a railway interlocking system. We show how the challenge of guaranteeing safety of the distributed application has been attacked by formally specifying and model checking...... the relevant distributed protocols. By doing that we obey the safety guidelines of the railway signalling domain, that require formal methods to support the certification of such products. We also show how formal modelling can help designing alternative distributed solutions, while maintaining adherence...

  13. Check of the bootstrap conditions for the gluon Reggeization

    International Nuclear Information System (INIS)

    Papa, A.

    2000-01-01

    The property of gluon Reggeization plays an essential role in the derivation of the Balitsky-Fadin-Kuraev-Lipatov (BFKL) equation for the cross sections at high energy √s in perturbative QCD. This property has been proved to all orders of perturbation theory in the leading logarithmic approximation and it is assumed to be valid also in the next-to-leading logarithmic approximation, where it has been checked only to the first three orders of perturbation theory. From s-channel unitarity, however, very stringent 'bootstrap' conditions can be derived which, if fulfilled, leave no doubts that gluon Reggeization holds

  14. Cross Check of NOvA Oscillation Probabilities

    Energy Technology Data Exchange (ETDEWEB)

    Parke, Stephen J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States). Dept. of Theoretical Physics; Messier, Mark D. [Indiana Univ., Bloomington, IN (United States). Dept. of Physics

    2018-01-12

    In this note we perform a cross check of the programs used by NOvA to calculate the 3-flavor oscillation probabilities with a independent program using a different method. The comparison is performed at 6 significant figures and the agreement, $|\\Delta P|/P$ is better than $10^{-5}$, as good as can be expected with 6 significant figures. In addition, a simple and accurate alternative method to calculate the oscillation probabilities is outlined and compared in the L/E range and matter density relevant for the NOvA experiment.

  15. An automatic drawing system for a report radioactive contamination check

    International Nuclear Information System (INIS)

    Saneyoshi, Keiji; Tomita, Satoru; Yoda, Isao

    2002-01-01

    An Automatic drawing system for a report of surface contamination check in a radiation controlled area has been developed. The system can print out the report applied for the format provided by the law from the raw data that is the output from measuring instruments. The task of a worker is only to insert an FD storing the data into a PC and to push a button. The system also yields contamination maps to indicate contamination points clearly. With this system the time to complete the report from the raw data could be decreased from more than two hours to 4 minutes. (author)

  16. UPPAAL-SMC: Statistical Model Checking for Priced Timed Automata

    DEFF Research Database (Denmark)

    Bulychev, Petr; David, Alexandre; Larsen, Kim Guldstrand

    2012-01-01

    in the form of probability distributions and compare probabilities to analyze performance aspects of systems. The focus of the survey is on the evolution of the tool – including modeling and specification formalisms as well as techniques applied – together with applications of the tool to case studies....... on a series of extensions of the statistical model checking approach generalized to handle real-time systems and estimate undecidable problems. U PPAAL - SMC comes together with a friendly user interface that allows a user to specify complex problems in an efficient manner as well as to get feedback...

  17. Efficient family-based model checking via variability abstractions

    DEFF Research Database (Denmark)

    Dimovski, Aleksandar; Al-Sibahi, Ahmad Salim; Brabrand, Claus

    2016-01-01

    Many software systems are variational: they can be configured to meet diverse sets of requirements. They can produce a (potentially huge) number of related systems, known as products or variants, by systematically reusing common parts. For variational models (variational systems or families...... with the abstract model checking of the concrete high-level variational model. This allows the use of Spin with all its accumulated optimizations for efficient verification of variational models without any knowledge about variability. We have implemented the transformations in a prototype tool, and we illustrate...

  18. Probabilistic Model Checking of Biological Systems with Uncertain Kinetic Rates

    Science.gov (United States)

    Barbuti, Roberto; Levi, Francesca; Milazzo, Paolo; Scatena, Guido

    We present an abstraction of the probabilistic semantics of Multiset Rewriting to formally express systems of reactions with uncertain kinetic rates. This allows biological systems modelling when the exact rates are not known, but are supposed to lie in some intervals. On these (abstract) models we perform probabilistic model checking obtaining lower and upper bounds for the probabilities of reaching states satisfying given properties. These bounds are under- and over-approximations, respectively, of the probabilities one would obtain by verifying the models with exact kinetic rates belonging to the intervals.

  19. [Discharge of very preterm infants from neonatology: check list].

    Science.gov (United States)

    Arnaud, F

    2004-02-01

    Key elements of the check list for neonatal discharge include: discharge discussion with parents, relation with maternal and child welfare assistants and family practitioner, scheduling of follow-up visits, request for insurance coverage, parental presence allowance, special education allowance, debriefing with nurses and nurses providers, clinical and biological appraisal, discharge prescription. For a former extremely premature baby, going home - often after a long hospitalization and a variety of pathologic problems - must be prepared and should not be decided in haste, not only for the baby and his/her parents, but also. for the neonatal staff!

  20. Runtime resource checking at WENDELSTEIN 7-X during plasma operation

    International Nuclear Information System (INIS)

    Laqua, H.

    2006-01-01

    The super conducting stellarator WENDELSTEIN 7-X (W7-X) will run pulses of up to 30 minutes duration. All discharge scenarios compatible with these capabilities will be supported by the control system: short pulses with arbitrary intervals, steady state discharges and arbitrary sequences of phases with different characteristics in one discharge. Long discharges with phases of different characteristics are understood as series of short discharge sections called '' segments ''. This, the heart of the control system is the '' segment control ''. Due to the long pulses and the innovative nature of plasma components a failure of a component during a discharge cannot be ruled out and has to be handled by the control system. Safety critical failures are handled by the safety system. In many cases the failure leads only to a degradation of the plasma quality and not to a safety critical situation. The segment control must detect the situation and steer the discharge into another state in which preferably the discharge can continue without the failed component or the discharge is gracefully brought to an end. Therefore the segment control system provides an online resource check of all components included in the segment control system. The rules of the resource check depend on the planned plasma characteristics given in the segment description, e.g. when not all heating systems are needed for the planned scenario a failure in an unneeded heating system will be tolerated. According to the hierarchical architecture of the segment control system described in [Laqua, H.; Niedermeyer, H.; Schacht, J.: Control System of Wendelstein 7-X Experiment. Fusion Engineering and Design 66-68, 669-673 (2003)] runtime resource checking is accomplished hierarchically, too. A system on a certain level in the hierarchy evaluates the feasibility of the physical characteristic demanded from this system to process this segment. Together with the feasibility information passed to this system by

  1. Performance of Low-Density Parity-Check Coded Modulation

    Science.gov (United States)

    Hamkins, Jon

    2010-01-01

    This paper reports the simulated performance of each of the nine accumulate-repeat-4-jagged-accumulate (AR4JA) low-density parity-check (LDPC) codes [3] when used in conjunction with binary phase-shift-keying (BPSK), quadrature PSK (QPSK), 8-PSK, 16-ary amplitude PSK (16- APSK), and 32-APSK.We also report the performance under various mappings of bits to modulation symbols, 16-APSK and 32-APSK ring scalings, log-likelihood ratio (LLR) approximations, and decoder variations. One of the simple and well-performing LLR approximations can be expressed in a general equation that applies to all of the modulation types.

  2. Automation of Geometry Input for Building Code Compliance Check

    DEFF Research Database (Denmark)

    Petrova, Ekaterina Aleksandrova; Johansen, Peter Lind; Jensen, Rasmus Lund

    2017-01-01

    . That has left the industry in constant pursuit of possibilities for integration of the tool within the Building Information Modelling environment so that the potential provided by the latter can be harvested and the processed can be optimized. This paper presents a solution for automated data extraction......Documentation of compliance with the energy performance regulations at the end of the detailed design phase is mandatory for building owners in Denmark. Therefore, besides multidisciplinary input, the building design process requires various iterative analyses, so that the optimal solutions can...... from building geometry created in Autodesk Revit and its translation to input for compliance check analysis....

  3. Operational workforce planning for check-in counters at airports

    DEFF Research Database (Denmark)

    Stolletz, Raik

    2010-01-01

    This paper addresses operation models for workforce planning for check-in systems at airports. We characterize different tasks of the hierarchical workforce planning problem with time-dependent demand. A binary linear programming formulation is developed for the fortnightly tour scheduling problem...... with flexible employee contracts. This binary programming model is solved for optimality by CPLEX for real-world demand scenarios with different workforce sizes. The numerical study analyzes the impact of the degree of flexibility and economies of scale. The model formulation is extended to generate convenient...

  4. Equivalence Checking of Combinational Circuits using Boolean Expression Diagrams

    DEFF Research Database (Denmark)

    Hulgaard, Henrik; Williams, Poul Frederick; Andersen, Henrik Reif

    1999-01-01

    The combinational logic-level equivalence problem is to determine whether two given combinational circuits implement the same Boolean function. This problem arises in a number of CAD applications, for example when checking the correctness of incremental design changes (performed either manually...... or by a design automation tool).This paper introduces a data structure called Boolean Expression Diagrams (BEDs) and two algorithms for transforming a BED into a Reduced Ordered Binary Decision Diagram (OBDD). BEDs are capable of representing any Boolean circuit in linear space and can exploit structural...

  5. Efficient Integrity Checking for Databases with Recursive Views

    DEFF Research Database (Denmark)

    Martinenghi, Davide; Christiansen, Henning

    2005-01-01

    Efficient and incremental maintenance of integrity constraints involving recursive views is a difficult issue that has received some attention in the past years, but for which no widely accepted solution exists yet. In this paper a technique is proposed for compiling such integrity constraints...... into incremental and optimized tests specialized for given update patterns. These tests may involve the introduction of new views, but for relevant cases of recursion, simplified integrity constraints are obtained that can be checked more efficiently than the original ones and without auxiliary views. Notably...

  6. Online Conformance Checking for Petri Nets and Event Streams

    DEFF Research Database (Denmark)

    Burattin, Andrea

    2017-01-01

    Within process mining, we can identify conformance checking as the task of computing the extent to which executions of a process model are in line with the reference behavior. Most approaches currently available in the literature (for imperative models, such as Petri nets) perform just a......, but the computation complexity is also restricted to a constant complexity per event analyzed. This enables the online analysis of an infinite stream of events. The tool is implemented as a package of the ProM framework and promising results have been obtained and are presented in this paper....

  7. Energy Audit Checks - A socioeconomic assessment; Energikartlaeggningscheckar - En samhaellsekonomisk utvaerdering

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-09-01

    This review is part of the Swedish Energy Agency's work with skills and methodology development on economic analyzes. The present socioeconomic analysis is the first of its kind to evaluate the current support for energy audit checks and is based on the instrument's purpose, goals and obstacles. Cost effectiveness is the main focus, as well as a description of the instrument's benefits and costs. The evaluation also aims to further develop the instrument in conjunction with the implementation of energy efficiency directive. Proposals for new instruments have however not been part of the mission.

  8. 75 FR 79312 - Requirements for Fingerprint-Based Criminal History Records Checks for Individuals Seeking...

    Science.gov (United States)

    2010-12-20

    ...-2008-0619] RIN 3150-AI25 Requirements for Fingerprint-Based Criminal History Records Checks for... a fingerprint- based criminal history records check before granting any individual unescorted access...

  9. Model checking coalitional games in shortage resource scenarios

    Directory of Open Access Journals (Sweden)

    Dario Della Monica

    2013-07-01

    Full Text Available Verification of multi-agents systems (MAS has been recently studied taking into account the need of expressing resource bounds. Several logics for specifying properties of MAS have been presented in quite a variety of scenarios with bounded resources. In this paper, we study a different formalism, called Priced Resource-Bounded Alternating-time Temporal Logic (PRBATL, whose main novelty consists in moving the notion of resources from a syntactic level (part of the formula to a semantic one (part of the model. This allows us to track the evolution of the resource availability along the computations and provides us with a formalisms capable to model a number of real-world scenarios. Two relevant aspects are the notion of global availability of the resources on the market, that are shared by the agents, and the notion of price of resources, depending on their availability. In a previous work of ours, an initial step towards this new formalism was introduced, along with an EXPTIME algorithm for the model checking problem. In this paper we better analyze the features of the proposed formalism, also in comparison with previous approaches. The main technical contribution is the proof of the EXPTIME-hardness of the the model checking problem for PRBATL, based on a reduction from the acceptance problem for Linearly-Bounded Alternating Turing Machines. In particular, since the problem has multiple parameters, we show two fixed-parameter reductions.

  10. Compositional model checking of concurrent systems, with Petri nets

    Directory of Open Access Journals (Sweden)

    Paweł Sobociński

    2016-03-01

    Full Text Available Compositionality and process equivalence are both standard concepts of process algebra. Compositionality means that the behaviour of a compound system relies only on the behaviour of its components, i.e. there is no emergent behaviour. Process equivalence means that the explicit statespace of a system takes a back seat to its interaction patterns: the information that an environment can obtain though interaction. Petri nets are a classical, yet widely used and understood, model of concurrency. Nevertheless, they have often been described as a non-compositional model, and tools tend to deal with monolithic, globally-specified models. This tutorial paper concentrates on Petri Nets with Boundaries (PNB: a compositional, graphical algebra of 1-safe nets, and its applications to reachability checking within the tool Penrose. The algorithms feature the use of compositionality and process equivalence, a powerful combination that can be harnessed to improve the performance of checking reachability and coverability in several common examples where Petri nets model realistic concurrent systems.

  11. SoS contract verification using statistical model checking

    Directory of Open Access Journals (Sweden)

    Alessandro Mignogna

    2013-11-01

    Full Text Available Exhaustive formal verification for systems of systems (SoS is impractical and cannot be applied on a large scale. In this paper we propose to use statistical model checking for efficient verification of SoS. We address three relevant aspects for systems of systems: 1 the model of the SoS, which includes stochastic aspects; 2 the formalization of the SoS requirements in the form of contracts; 3 the tool-chain to support statistical model checking for SoS. We adapt the SMC technique for application to heterogeneous SoS. We extend the UPDM/SysML specification language to express the SoS requirements that the implemented strategies over the SoS must satisfy. The requirements are specified with a new contract language specifically designed for SoS, targeting a high-level English- pattern language, but relying on an accurate semantics given by the standard temporal logics. The contracts are verified against the UPDM/SysML specification using the Statistical Model Checker (SMC PLASMA combined with the simulation engine DESYRE, which integrates heterogeneous behavioral models through the functional mock-up interface (FMI standard. The tool-chain allows computing an estimation of the satisfiability of the contracts by the SoS. The results help the system architect to trade-off different solutions to guide the evolution of the SoS.

  12. Model checking as an aid to procedure design

    International Nuclear Information System (INIS)

    Zhang, Wenhu

    2001-01-01

    The OECD Halden Reactor Project has been actively working on computer assisted operating procedures for many years. The objective of the research has been to provide computerised assistance for procedure design, verification and validation, implementation and maintenance. For the verification purpose, the application of formal methods has been considered in several reports. The recent formal verification activity conducted at the Halden Project is based on using model checking to the verification of procedures. This report presents verification approaches based on different model checking techniques and tools for the formalization and verification of operating procedures. Possible problems and relative merits of the different approaches are discussed. A case study of one of the approaches is presented to show the practical application of formal verification. Application of formal verification in the traditional procedure design process can reduce the human resources involved in reviews and simulations, and hence reduce the cost of verification and validation. A discussion of the integration of the formal verification with the traditional procedure design process is given at the end of this report. (Author)

  13. Approximate Model Checking of PCTL Involving Unbounded Path Properties

    Science.gov (United States)

    Basu, Samik; Ghosh, Arka P.; He, Ru

    We study the problem of applying statistical methods for approximate model checking of probabilistic systems against properties encoded as PCTL formulas. Such approximate methods have been proposed primarily to deal with state-space explosion that makes the exact model checking by numerical methods practically infeasible for large systems. However, the existing statistical methods either consider a restricted subset of PCTL, specifically, the subset that can only express bounded until properties; or rely on user-specified finite bound on the sample path length. We propose a new method that does not have such restrictions and can be effectively used to reason about unbounded until properties. We approximate probabilistic characteristics of an unbounded until property by that of a bounded until property for a suitably chosen value of the bound. In essence, our method is a two-phase process: (a) the first phase is concerned with identifying the bound k 0; (b) the second phase computes the probability of satisfying the k 0-bounded until property as an estimate for the probability of satisfying the corresponding unbounded until property. In both phases, it is sufficient to verify bounded until properties which can be effectively done using existing statistical techniques. We prove the correctness of our technique and present its prototype implementations. We empirically show the practical applicability of our method by considering different case studies including a simple infinite-state model, and large finite-state models such as IPv4 zeroconf protocol and dining philosopher protocol modeled as Discrete Time Markov chains.

  14. Model Checking Degrees of Belief in a System of Agents

    Science.gov (United States)

    Raimondi, Franco; Primero, Giuseppe; Rungta, Neha

    2014-01-01

    Reasoning about degrees of belief has been investigated in the past by a number of authors and has a number of practical applications in real life. In this paper we present a unified framework to model and verify degrees of belief in a system of agents. In particular, we describe an extension of the temporal-epistemic logic CTLK and we introduce a semantics based on interpreted systems for this extension. In this way, degrees of beliefs do not need to be provided externally, but can be derived automatically from the possible executions of the system, thereby providing a computationally grounded formalism. We leverage the semantics to (a) construct a model checking algorithm, (b) investigate its complexity, (c) provide a Java implementation of the model checking algorithm, and (d) evaluate our approach using the standard benchmark of the dining cryptographers. Finally, we provide a detailed case study: using our framework and our implementation, we assess and verify the situational awareness of the pilot of Air France 447 flying in off-nominal conditions.

  15. Assertion checking environment (ACE) for formal verification of C programs

    International Nuclear Information System (INIS)

    Sharma, Babita; Dhodapkar, S.D.; Ramesh, S.

    2003-01-01

    In this paper we describe an Assertion Checking Environment (ACE) for compositional verification of programs, which are written in an industrially sponsored safe subset of C programming language called MISRA C [Guidelines for the Use of the C Language in Vehicle Based Software, 1998]. The theory is based on Hoare logic [Commun. ACM 12 (1969) 576] and the C programs are verified using static assertion checking technique. First the functional specifications of the program, captured in the form of pre- and post-conditions for each C function, are derived from the specifications. These pre- and post-conditions are then introduced as assertions (also called annotations or formal comments) in the program code. The assertions are then proved formally using ACE and theorem proving tool called Stanford Temporal Prover [The Stanford Temporal Prover User's Manual, 1998]. ACE has been developed by us and consists mainly of a translator c2spl, a GUI and some utility programs. The technique and tools developed are targeted towards verification of real-time embedded software

  16. Efficient Parallel Statistical Model Checking of Biochemical Networks

    Directory of Open Access Journals (Sweden)

    Paolo Ballarini

    2009-12-01

    Full Text Available We consider the problem of verifying stochastic models of biochemical networks against behavioral properties expressed in temporal logic terms. Exact probabilistic verification approaches such as, for example, CSL/PCTL model checking, are undermined by a huge computational demand which rule them out for most real case studies. Less demanding approaches, such as statistical model checking, estimate the likelihood that a property is satisfied by sampling executions out of the stochastic model. We propose a methodology for efficiently estimating the likelihood that a LTL property P holds of a stochastic model of a biochemical network. As with other statistical verification techniques, the methodology we propose uses a stochastic simulation algorithm for generating execution samples, however there are three key aspects that improve the efficiency: first, the sample generation is driven by on-the-fly verification of P which results in optimal overall simulation time. Second, the confidence interval estimation for the probability of P to hold is based on an efficient variant of the Wilson method which ensures a faster convergence. Third, the whole methodology is designed according to a parallel fashion and a prototype software tool has been implemented that performs the sampling/verification process in parallel over an HPC architecture.

  17. Model-checking techniques based on cumulative residuals.

    Science.gov (United States)

    Lin, D Y; Wei, L J; Ying, Z

    2002-03-01

    Residuals have long been used for graphical and numerical examinations of the adequacy of regression models. Conventional residual analysis based on the plots of raw residuals or their smoothed curves is highly subjective, whereas most numerical goodness-of-fit tests provide little information about the nature of model misspecification. In this paper, we develop objective and informative model-checking techniques by taking the cumulative sums of residuals over certain coordinates (e.g., covariates or fitted values) or by considering some related aggregates of residuals, such as moving sums and moving averages. For a variety of statistical models and data structures, including generalized linear models with independent or dependent observations, the distributions of these stochastic processes tinder the assumed model can be approximated by the distributions of certain zero-mean Gaussian processes whose realizations can be easily generated by computer simulation. Each observed process can then be compared, both graphically and numerically, with a number of realizations from the Gaussian process. Such comparisons enable one to assess objectively whether a trend seen in a residual plot reflects model misspecification or natural variation. The proposed techniques are particularly useful in checking the functional form of a covariate and the link function. Illustrations with several medical studies are provided.

  18. Status Checking System of Home Appliances using machine learning

    Directory of Open Access Journals (Sweden)

    Yoon Chi-Yurl

    2017-01-01

    Full Text Available This paper describes status checking system of home appliances based on machine learning, which can be applied to existing household appliances without networking function. Designed status checking system consists of sensor modules, a wireless communication module, cloud server, android application and a machine learning algorithm. The developed system applied to washing machine analyses and judges the four-kinds of appliance’s status such as staying, washing, rinsing and spin-drying. The measurements of sensor and transmission of sensing data are operated on an Arduino board and the data are transmitted to cloud server in real time. The collected data are parsed by an Android application and injected into the machine learning algorithm for learning the status of the appliances. The machine learning algorithm compares the stored learning data with collected real-time data from the appliances. Our results are expected to contribute as a base technology to design an automatic control system based on machine learning technology for household appliances in real-time.

  19. Welfare Checks, Drug Consumption, and Health: Evidence from Vancouver Injection Drug Users

    Science.gov (United States)

    Riddell, Chris; Riddell, Rosemarie

    2006-01-01

    This paper investigates the link between welfare payments and drug use among injection drug users. The authors find an increase in the likelihood of an overdose in the days following check arrival, and in the probability of leaving the hospital against medical advice (AMA) on check day. Using the check arrival date as an instrument, we estimate…

  20. 77 FR 27561 - Requirements for Fingerprint-Based Criminal History Records Checks for Individuals Seeking...

    Science.gov (United States)

    2012-05-11

    ... Fingerprinting and Criminal History Records Check Requirements for Unescorted Access to Research and Test... Criminal History Records Check Requirements for Unescorted Access to the General Atomics' Research and Test...-Based Criminal History Records Checks for Individuals Seeking Unescorted Access to Non-Power Reactors...

  1. Combining Decision Diagrams and SAT Procedures for Efficient Symbolic Model Checking

    DEFF Research Database (Denmark)

    Williams, Poul Frederick; Biere, Armin; Clarke, Edmund M.

    2000-01-01

    , combined with BDDs and SAT-solvers to perform satisfiability checking. As a result we are able to model check systems for which standard BDD-based methods fail. For example, we model check a liveness property of a 256 bit shift-and-add multiplier and we are able to find a previously undetected bug...

  2. Encoded physics knowledge in checking codes for nuclear cross section libraries at Los Alamos

    Science.gov (United States)

    Parsons, D. Kent

    2017-09-01

    Checking procedures for processed nuclear data at Los Alamos are described. Both continuous energy and multi-group nuclear data are verified by locally developed checking codes which use basic physics knowledge and common-sense rules. A list of nuclear data problems which have been identified with help of these checking codes is also given.

  3. 42 CFR 457.216 - Treatment of uncashed or canceled (voided) CHIP checks.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Treatment of uncashed or canceled (voided) CHIP... canceled (voided) CHIP checks. (a) Purpose. This section provides rules to ensure that States refund the... section— Canceled (voided) check means an CHIP check issued by a State or fiscal agent that prior to its...

  4. 28 CFR 105.23 - Procedure for requesting criminal history record check.

    Science.gov (United States)

    2010-07-01

    ... HISTORY BACKGROUND CHECKS Private Security Officer Employment § 105.23 Procedure for requesting criminal... checks, declaring that it is an authorized employer that employs private security officers; that all fingerprints and requests for criminal history background checks are being submitted for private security...

  5. Assessing Personality and Mood With Adjective Check List Methodology: A Review

    Science.gov (United States)

    Craig, Robert J.

    2005-01-01

    This article addresses the benefits and problems in using adjective check list methodology to assess personality. Recent developments in this assessment method are reviewed, emphasizing seminal adjective-based personality tests (Gough's Adjective Check List), mood tests (Lubin's Depressive Adjective Test, Multiple Affect Adjective Check List),…

  6. Cardiovascular risk at health checks performed opportunistically or following an invitation letter. Cohort study.

    Science.gov (United States)

    Gulliford, Martin C; Khoshaba, Bernadette; McDermott, Lisa; Cornelius, Victoria; Ashworth, Mark; Fuller, Frances; Miller, Jane; Dodhia, Hiten; Wright, Alison J

    2017-06-17

    A population-based programme of health checks has been established in England. Participants receive postal invitations through a population-based call-recall system but health check providers may also offer health checks opportunistically. We compared cardiovascular risk scores for 'invited' and 'opportunistic' health checks. Cohort study of all health checks completed at 18 general practices from July 2013 to June 2015. For each general practice, cardiovascular (CVD) risk scores were compared by source of check and pooled using meta-analysis. Effect estimates were compared by gender, age-group, ethnicity and fifths of deprivation. There were 6184 health checks recorded (2280 invited and 3904 opportunistic) with CVD risk scores recorded for 5359 (87%) participants. There were 17.0% of invited checks and 22.2% of opportunistic health checks with CVD risk score ≥10%; a relative increment of 28% (95% confidence interval: 14-44%, P < 0.001). In the most deprived quintile, 15.3% of invited checks and 22.4% of opportunistic checks were associated with elevated CVD risk (adjusted odds ratio: 1.94, 1.37-2.74, P  < 0.001). Respondents at health checks performed opportunistically are at higher risk of cardiovascular disease than those participating in response to a standard invitation letter, potentially reducing the effect of uptake inequalities. © The Author 2017. Published by Oxford University Press on behalf of Faculty of Public Health.

  7. Dissecting Immunogenicity of Monoclonal Antibodies

    National Research Council Canada - National Science Library

    Snyder, Christopher

    2002-01-01

    The potential of monoclonal antibodies, (mAbs), for use in therapeutic and diagnostic applications has not been fully realized in part due to counter-immune responses that often arise in patient recipients of mAb...

  8. Dissecting Immunogenicity of Monoclonal Antibodies

    National Research Council Canada - National Science Library

    Snyder, Christopher

    2003-01-01

    The potential of monoclonal antibodies, (mAbs), for use in therapeutic and diagnostic applications has not been fully realized in part due to counter-immune responses that often arise in patient recipients of mAb...

  9. Antisperm antibodies and fertility association.

    Science.gov (United States)

    Restrepo, B; Cardona-Maya, W

    2013-10-01

    To evaluate the relation between antisperm antibodies (ASA) and human fertility by reviewing the scientific literature of the last 45 years. We carried out a review of scientific literature about antisperm antibodies and infertility published in spanish or english in databases as Pubmed, Medline, Scielo, some books and another gray literature include information related to this review and that is published in the last 45 years. Infertile couples suffer infertility by immunological mechanisms mainly by the presence of antisperm antibodies ASA in blood, semen or cervicovaginal secretions; the formation of ASA in men and women may be associated with disturbance in immunomodulatory mechanisms that result in functional impairment of sperm and thus its inability to fertilize the oocyte. Immunological infertility caused by ASA is the result of interference of these antibodies in various stages of fertilization process, inhibiting the ability of interaction between sperm and oocyte. Copyright © 2012 AEU. Published by Elsevier Espana. All rights reserved.

  10. Antibody Drug Conjugates: Preclinical Considerations.

    Science.gov (United States)

    Bornstein, Gadi G

    2015-05-01

    The development path for antibody drug conjugates (ADCs) is more complex and challenging than for unmodified antibodies. While many of the preclinical considerations for both unmodified and antibody drug conjugates are shared, special considerations must be taken into account when developing an ADC. Unlike unmodified antibodies, an ADC must preferentially bind to tumor cells, internalize, and traffic to the appropriate intracellular compartment to release the payload. Parameters that can impact the pharmacological properties of this class of therapeutics include the selection of the payload, the type of linker, and the methodology for payload drug conjugation. Despite a plethora of in vitro assays and in vivo models to screen and evaluate ADCs, the challenge remains to develop improved preclinical tools that will be more predictive of clinical outcome. This review will focus on preclinical considerations for clinically validated small molecule ADCs. In addition, the lessons learned from Mylotarg®, the first in class FDA-approved ADC, are highlighted.

  11. Monoclonal antibodies technology. Protocols

    International Nuclear Information System (INIS)

    Acevado Castro, B.E.

    1997-01-01

    Full text: Immunization. The first step in preparing useful monoclonal antibodies (MAbs) is to immunize an animal (Balb/c for example) with an appropriate antigen. Methods (only for soluble antigen): Solubilize selected antigen in Phosphate buffer solution (PBS) at pH 7.2-7.4, ideally at a final concentration per animal between 10 to 50 μg/ml. It is recommended that the antigen under consideration be incorporated into the emulsion adjuvants in 1:1 volumetric relation. We commonly use Frend's adjuvant (FA) to prepared immunized solution. The first immunization should be prepared with complete FA, and the another could be prepared with incomplete FA. It is recommended to inject mice with 0.2 ml intraperitoneal (ip) or subcutaneous (sc). Our experience suggests the sc route is the preferred route. A minimum protocol for immunizing mice to generate cells for preparing hybridomas is s follows: immunize sc on day 0, boost sc on day 21, take a trial bleeding on day 26; if antibody titters are satisfactory, boost ip on day 35 with antigen only, and remove the spleen to obtain cells for fusion on day 38. Fusion protocol. The myeloma cell line we are using is X63 Ag8.653. At the moment of fusion myeloma cells need a good viability (at least a 95%). 1. Remove the spleen cells from immunized mice using sterile conditions. An immune spleen should yield between 7 a 10x10 7 nucleated cells. 2. Place the spleen in 20 ml of serum-free RPMI 1640 in a Petri dish. Using a needle and syringe, inject the spleen with medium to distend and disrupt the spleen stroma and free the nucleated cells. 3. Flush the cell suspension with a Pasteur pipet to disperse clumps of cells. 4. Centrifuge the spleen cell suspension at 250g for 10 min. Resuspend the pellet in serum-free RPMI 1640. Determine cell concentration using Neuhabuer chamber. 5. Mix the myeloma cells and spleen cells in a conical 50-ml tube in serum-free RPMI 1640, 1 x10 7 spleen cells to 1x10 6 myeloma cells (ratio 10:1). Centrifuge

  12. Radiolabeled monoclonal antibodies: a review

    International Nuclear Information System (INIS)

    Toledo e Souza, I.T. de; Okada, H.

    1990-05-01

    Since the description by Kohler and Milstein 1975 of their technique for producing monoclonal antibodies of predefined specificity, it has become a mainstay in most laboratories that utilize immunochemical techniques to study problems in basic, applied or clinical research. Paradoxically, the very success of monoclonal antibodies has generated a literature which is now so vast and scattered that it has become difficult to obtain a perspective. This brief review represents the distillation of many publications relating to the production and use of monoclonaal antibodies as radiopharmaceuticals. Significant advances were made possible in the last few years by combined developments in the fields of tumor-associated antigens and of monoclonal antibodies. In fact monoclonal antibodies against some well defined tumor-associated antigens, has led to significantly greater practical possibilities for producing highly specific radiolabeled antibodies as radiopharmaceuticals for diagnosis and therapy of human tumors. One of the main requirements of this methodology is the availability of stable radiopharmaceutical reagents which after labeling in vivo injection retain the capacity of specific interaction with the defined antigen and their molecular integrity. Since injection into human is the objetive of this kind of study all the specifications of radiopharmaceutical have to be fulfilled e.g. sterility, apirogenicity and absence of toxicity. (author) [pt

  13. Avian Diagnostic and Therapeutic Antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, David Sherman [UND SMHS

    2012-12-31

    A number of infectious agents have the potential of causing significant clinical symptomology and even death, but dispite this, the number of incidence remain below the level that supports producing a vaccine. Therapeutic antibodies provide a viable treatment option for many of these diseases. We proposed that antibodies derived from West Nile Virus (WNV) immunized geese would be able to treat WNV infection in mammals and potential humans. We demonstrated that WNV specific goose antibodies are indeed successful in treating WNV infection both prophylactically and therapeutically in a golden hamster model. We demonstrated that the goose derived antibodies are non-reactogenic, i.e. do not cause an inflammatory response with multiple exposures in mammals. We also developed both a specific pathogen free facility to house the geese during the antibody production phase and a patent-pending purification process to purify the antibodies to greater than 99% purity. Therefore, the success of these study will allow a cost effective rapidly producible therapeutic toward clinical testing with the necessary infrastructure and processes developed and in place.

  14. Tabhu: tools for antibody humanization.

    KAUST Repository

    Olimpieri, Pier Paolo

    2014-10-09

    SUMMARY: Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to recognize their cognate antigens with high specificity and affinity, and a high yield at reasonable costs in model animals. Unfortunately, when administered to human patients, xenogeneic antibodies can elicit unwanted and dangerous immunogenic responses. Antibody humanization methods are designed to produce molecules with a better safety profile still maintaining their ability to bind the antigen. This can be accomplished by grafting the non-human regions determining the antigen specificity into a suitable human template. Unfortunately, this procedure may results in a partial or complete loss of affinity of the grafted molecule that can be restored by back-mutating some of the residues of human origin to the corresponding murine ones. This trial-and-error procedure is hard and involves expensive and time-consuming experiments. Here we present tools for antibody humanization (Tabhu) a web server for antibody humanization. Tabhu includes tools for human template selection, grafting, back-mutation evaluation, antibody modelling and structural analysis, helping the user in all the critical steps of the humanization experiment protocol. AVAILABILITY: http://www.biocomputing.it/tabhu CONTACT: anna.tramontano@uniroma1.it, pierpaolo.olimpieri@uniroma1.it SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

  15. Methodology for Check Valve Selection to Maintain the Integrity of Pipeline against the Check Valve Slam for the KIJANG Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dayong; Yoon, Hyungi; Seo, Kyoungwoo; Kim, Seonhoon [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    The check valve slam results in a water hammer and unexpected system pressure rise in the pipeline. Sometimes, the pressure rise by check valve slam in the pipeline exceeds the design pressure and then it causes the rupture of pipeline. Therefore, check valve slam significantly influences on the integrity of pipe. Especially, this it is most likely to occur by check valve installed in the discharge of pump when one pump trips among the two or more running in parallel pump system. This study focuses on the check valve selection to maintain the integrity of PCS pipeline against the check valve slam. If design head for KJRR PCS pipeline is higher than the sum of static head and 11 m, any type check valves can be installed at the discharge of pump. However, if design head for KJRR PCS pipeline is lower than the sum of static head and 11 m, installation of swing and ball check on the discharge of pump must be avoid to prevent the rupture of PCS pipeline.

  16. Methodology for Check Valve Selection to Maintain the Integrity of Pipeline against the Check Valve Slam for the KIJANG Research Reactor

    International Nuclear Information System (INIS)

    Kim, Dayong; Yoon, Hyungi; Seo, Kyoungwoo; Kim, Seonhoon

    2016-01-01

    The check valve slam results in a water hammer and unexpected system pressure rise in the pipeline. Sometimes, the pressure rise by check valve slam in the pipeline exceeds the design pressure and then it causes the rupture of pipeline. Therefore, check valve slam significantly influences on the integrity of pipe. Especially, this it is most likely to occur by check valve installed in the discharge of pump when one pump trips among the two or more running in parallel pump system. This study focuses on the check valve selection to maintain the integrity of PCS pipeline against the check valve slam. If design head for KJRR PCS pipeline is higher than the sum of static head and 11 m, any type check valves can be installed at the discharge of pump. However, if design head for KJRR PCS pipeline is lower than the sum of static head and 11 m, installation of swing and ball check on the discharge of pump must be avoid to prevent the rupture of PCS pipeline

  17. Checking the new IRI model The bottomside B parameters

    CERN Document Server

    Mosert, M; Ezquer, R; Lazo, B; Miro, G

    2002-01-01

    Electron density profiles obtained at Pruhonice (50.0, 15.0), El Arenosillo (37.1, 353.2) and Havana (23, 278) were used to check the bottom-side B parameters BO (thickness parameter) and B1 (shape parameter) predicted by the new IRI - 2000 version. The electron density profiles were derived from ionograms using the ARP technique. The data base includes daytime and nighttime ionograms recorded under different seasonal and solar activity conditions. Comparisons with IRI predictions were also done. The analysis shows that: a) The parameter B1 given by IRI 2000 reproduces better the observed ARP values than the IRI-90 version and b) The observed BO values are in general well reproduced by both IRI versions: IRI-90 and IRI-2000.

  18. Checking the Polarity of Superconducting Multipole LHC Magnets

    CERN Document Server

    Buzio, M; Brun, G; Fievez, G; Galbraith, P; García-Pérez, J; López, R; Masi, A; Russenschuck, Stephan; Smirnov, N; Tikhov, A

    2006-01-01

    This paper describes the design and operation of the â€ワPolarity Checker”, a scanning probe designed to check multipole field order, type and polarity of superconducting LHC magnets. First we introduce the measurement method, based on the harmonic analysis of the radial field component picked up by a rotating Hall sensor at different current levels. Then we describe the hardware and the software of the system, which features automatic powering, data acquisition and treatment, discussing the achieved sensitivity and performance. Finally we provide a summary of the test results on the first 505 cryoassemblies, showing how the system was usefully employed to detect some potentially harmful connection errors.

  19. Neurology check list. 5. rev. and enl. ed.; Checkliste Neurologie

    Energy Technology Data Exchange (ETDEWEB)

    Grehl, Holger [Evangelisches und Johanniter Klinikum, Duisburg (Germany). Neurologische Klinik; Reinhardt, Frank

    2013-02-01

    The neurology check list covers the following issues, organized in four parts: Grey part - diagnostic fundamentals, therapeutic principles: clinical neurological examination, liquor puncture, specific laboratory diagnostics, neurophysical diagnostics, imaging techniques, therapeutic principles, legal aspects, neurological assessment. Green Part - leading syndromes and leading symptoms. Blue part - neurological disease appearance: pains in head and face, pain syndrome, congenital and development disturbances, liquor circulation disturbances, ZNS hemorrhages, tumors and neoplasm, paraneoplastic syndromes, inflammatory diseases of the nervous system, dementia diseases, metabolic and other encephalopathy, cerebellum diseases and system surmounting processes, movement degeneration, basal ganglion diseases, epilepsy, non-epileptic attacks, medulla diseases, brain nerve diseases, plexus lesions, radicular lesions, peripheric neuropathy, neuromuscular transfer disturbances, muscular diseases. Red part: neurological intensive medicine.

  20. Checks and balances: the welcomed tension between philosophy and science.

    Science.gov (United States)

    Watson, Jamie Carlin; Arp, Robert

    2008-03-01

    There is a tension between science and philosophy, but this tension need not engender enmity or derision. Scientists and philosophers can work together, and we argue that working together is beneficial to both, even if it is sometimes uncomfortable. We offer examples of how philosophy can autonomously and effectively inform scientific practice. Science and philosophy share certain methodological concerns and practices; therefore, scientists who disregard philosophy are vulnerable to critical conceptual mistakes. If our arguments are correct, and if it can also be shown that science informs philosophy, then, while it is possible for both disciplines to operate autonomously, each should welcome the checks and balances that each provides for one another in the investigation and explanation of reality.

  1. Applying Model Checking to Industrial-Sized PLC Programs

    CERN Document Server

    AUTHOR|(CDS)2079190; Darvas, Daniel; Blanco Vinuela, Enrique; Tournier, Jean-Charles; Bliudze, Simon; Blech, Jan Olaf; Gonzalez Suarez, Victor M

    2015-01-01

    Programmable logic controllers (PLCs) are embedded computers widely used in industrial control systems. Ensuring that a PLC software complies with its specification is a challenging task. Formal verification has become a recommended practice to ensure the correctness of safety-critical software but is still underused in industry due to the complexity of building and managing formal models of real applications. In this paper, we propose a general methodology to perform automated model checking of complex properties expressed in temporal logics (\\eg CTL, LTL) on PLC programs. This methodology is based on an intermediate model (IM), meant to transform PLC programs written in various standard languages (ST, SFC, etc.) to different modeling languages of verification tools. We present the syntax and semantics of the IM and the transformation rules of the ST and SFC languages to the nuXmv model checker passing through the intermediate model. Finally, two real cases studies of \\CERN PLC programs, written mainly in th...

  2. Methods to model-check parallel systems software

    International Nuclear Information System (INIS)

    Matlin, O. S.; McCune, W.; Lusk, E.

    2003-01-01

    We report on an effort to develop methodologies for formal verification of parts of the Multi-Purpose Daemon (MPD) parallel process management system. MPD is a distributed collection of communicating processes. While the individual components of the collection execute simple algorithms, their interaction leads to unexpected errors that are difficult to uncover by conventional means. Two verification approaches are discussed here: the standard model checking approach using the software model checker SPIN and the nonstandard use of a general-purpose first-order resolution-style theorem prover OTTER to conduct the traditional state space exploration. We compare modeling methodology and analyze performance and scalability of the two methods with respect to verification of MPD

  3. SimCheck: An Expressive Type System for Simulink

    Science.gov (United States)

    Roy, Pritam; Shankar, Natarajan

    2010-01-01

    MATLAB Simulink is a member of a class of visual languages that are used for modeling and simulating physical and cyber-physical systems. A Simulink model consists of blocks with input and output ports connected using links that carry signals. We extend the type system of Simulink with annotations and dimensions/units associated with ports and links. These types can capture invariants on signals as well as relations between signals. We define a type-checker that checks the wellformedness of Simulink blocks with respect to these type annotations. The type checker generates proof obligations that are solved by SRI's Yices solver for satisfiability modulo theories (SMT). This translation can be used to detect type errors, demonstrate counterexamples, generate test cases, or prove the absence of type errors. Our work is an initial step toward the symbolic analysis of MATLAB Simulink models.

  4. Using Model Checking for Analyzing Distributed Power Control Problems

    DEFF Research Database (Denmark)

    Brihaye, Thomas; Jungers, Marc; Lasaulce, Samson

    2010-01-01

    Model checking (MC) is a formal verification technique which has been known and still knows a resounding success in the computer science community. Realizing that the distributed power control ( PC) problem can be modeled by a timed game between a given transmitter and its environment, the authors...... wanted to know whether this approach can be applied to distributed PC. It turns out that it can be applied successfully and allows one to analyze realistic scenarios including the case of discrete transmit powers and games with incomplete information. The proposed methodology is as follows. We state some...... objectives a transmitter-receiver pair would like to reach. The network is modeled by a game where transmitters are considered as timed automata interacting with each other. The objectives are then translated into timed alternating-time temporal logic formulae and MC is exploited to know whether the desired...

  5. Using Model Checking for Analyzing Distributed Power Control Problems

    Directory of Open Access Journals (Sweden)

    Thomas Brihaye

    2010-01-01

    Full Text Available Model checking (MC is a formal verification technique which has been known and still knows a resounding success in the computer science community. Realizing that the distributed power control (PC problem can be modeled by a timed game between a given transmitter and its environment, the authors wanted to know whether this approach can be applied to distributed PC. It turns out that it can be applied successfully and allows one to analyze realistic scenarios including the case of discrete transmit powers and games with incomplete information. The proposed methodology is as follows. We state some objectives a transmitter-receiver pair would like to reach. The network is modeled by a game where transmitters are considered as timed automata interacting with each other. The objectives are then translated into timed alternating-time temporal logic formulae and MC is exploited to know whether the desired properties are verified and determine a winning strategy.

  6. Using Stochastic Model Checking to Provision Complex Business Services

    DEFF Research Database (Denmark)

    Herbert, Luke Thomas; Sharp, Robin

    2012-01-01

    We present a framework for modelling and analysis of real-world business workflows. Business processes regularly form the basis for the design of software services, and frequently display complex stochastic behaviour. The accurate evaluation of their qualitative aspects can allow for determining...... bounds on resources consumed during execution of business processes. Accurate resource provisioning is often central to ensuring the safe execution of a process. We first introduce a formalised core subset of the Business Process Modelling and Notation (BPMN), which we extend with probabilistic and non......-deterministic branching and reward annotations. We then develop an algorithm for the efficient translation of these models into the guarded command language used by the model checker PRISM, in turn enabling model checking of BPMN processes and allowing for the calculation of a wide range of quantitative properties...

  7. Scintigraphic studies for checking postoperative healing after cystectomies

    International Nuclear Information System (INIS)

    Wickenhauser, J.

    1982-01-01

    Defect filling of extensive cavities in the region of the jaw after cystectomies of large odontogenic cysts constitutes a particular problem as the restoration of the carrying capacity of the crest of the jaw is of decisive signifance for sufficient prosthetic surgery. The fibrin-spongiosa graft method was performed in all patients; both homologous and autologous cancellous tissue was used. In addition to X-ray examinations, for the first time nuclear medical examination methods were used for assessing the future site of the graft and checking the postoperative healing process. This method permitted not only detection of an osteomyelitis during pre-operative examinations, but in one case also a disturbance of the postoperative healing process was discovered. Therefore, the combined X-ray - isotope examination constitutes the method of choice as regards diagnosis, planning of treatment and control of the healing process. (Author)

  8. LHCb: Analysing DIRAC's Behavior using Model Checking with Process Algebra

    CERN Multimedia

    Remenska, Daniela

    2012-01-01

    DIRAC is the Grid solution designed to support LHCb production activities as well as user data analysis. Based on a service-oriented architecture, DIRAC consists of many cooperating distributed services and agents delivering the workload to the Grid resources. Services accept requests from agents and running jobs, while agents run as light-weight components, fulfilling specific goals. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check for changes in the service states, and react to these accordingly. A characteristic of DIRAC's architecture is the relatively low complexity in the logic of each agent; the main source of complexity lies in their cooperation. These agents run concurrently, and communicate using the services' databases as a shared memory for synchronizing the state transitions. Although much effort is invested in making DIRAC reliable, entities occasionally get into inconsistent states, leadi...

  9. Model-checking dense-time Duration Calculus

    DEFF Research Database (Denmark)

    Fränzle, Martin

    2004-01-01

    Since the seminal work of Zhou Chaochen, M. R. Hansen, and P. Sestoft on decidability of dense-time Duration Calculus [Zhou, Hansen, Sestoft, 1993] it is well-known that decidable fragments of Duration Calculus can only be obtained through withdrawal of much of the interesting vocabulary...... of this logic. While this was formerly taken as an indication that key-press verification of implementations with respect to elaborate Duration Calculus specifications were also impossible, we show that the model property is well decidable for realistic designs which feature natural constraints...... suitably sparser model classes we obtain model-checking procedures for rich subsets of Duration Calculus. Together with undecidability results also obtained, this sheds light upon the exact borderline between decidability and undecidability of Duration Calculi and related logics....

  10. Neurology check list. 5. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Grehl, Holger; Reinhardt, Frank

    2013-01-01

    The neurology check list covers the following issues, organized in four parts: Grey part - diagnostic fundamentals, therapeutic principles: clinical neurological examination, liquor puncture, specific laboratory diagnostics, neurophysical diagnostics, imaging techniques, therapeutic principles, legal aspects, neurological assessment. Green Part - leading syndromes and leading symptoms. Blue part - neurological disease appearance: pains in head and face, pain syndrome, congenital and development disturbances, liquor circulation disturbances, ZNS hemorrhages, tumors and neoplasm, paraneoplastic syndromes, inflammatory diseases of the nervous system, dementia diseases, metabolic and other encephalopathy, cerebellum diseases and system surmounting processes, movement degeneration, basal ganglion diseases, epilepsy, non-epileptic attacks, medulla diseases, brain nerve diseases, plexus lesions, radicular lesions, peripheric neuropathy, neuromuscular transfer disturbances, muscular diseases. Red part: neurological intensive medicine.

  11. [Difficulties in implementing a surgical check list in operating theatres].

    Science.gov (United States)

    Soria-Aledo, Víctor; Da Silva, ZeNewton Andre; Saturno, Pedro J; Grau-Polan, Marina; Carrillo-Alcaraz, Andrés

    2012-03-01

    To assess the level of implementation and the factors associated with the compliance to the surgical check list (SCL) proposed by the WHO, in surgery departments in public hospitals in the Murcia Region of Spain. A retrospective cross-sectional study was conducted using a random, non-proportional, and stratified sample in each hospital. The sample size was established as 10 cases per centre, with a total of 90 surgical operations. The data analysis included the percentage of compliance of the variables of interest (presence of an SCL and the compliance to it, complete, by sections and by items) at regional level, according to hospital, hospital groups, depending on the size; the type of anaesthesia (local, regional or general); the work shift (morning or afternoon); as well as the age and sex of the surgery patients. The check list was found in the medical records in 75 cases (83.33%; confidence interval [CI]: 78.7% - 87.5%), and complied with in full in 25 cases (27.8%; 95% CI: 18.5% - 37.0%). The percentage of items complied with was 70.1% (95% CI: 67.9%-72.2%). The percentage compliance varied by hospital, from 35.8% to 98.9%. The logistic regression analysis showed significance in the variables such as, the size of the hospital (the list was more likely to be complied with in small and medium hospitals) and operations with local anaesthetic as a negative predictive factor of compliance. The SCL is used, but is not always complied with, and not homogeneously in all its sections. There is also significant variation between the public hospitals in the Murcia Region of Spain. Copyright © 2011 AEC. Published by Elsevier Espana. All rights reserved.

  12. Comparative evaluation of Map-Check and Arc-Check for dosimetric verification in patients treaties with IMRT; Evaluacion comparativa de MapCHECK y ArcCHECK para verificacion dosimetrica en pacientes tratados con IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, B.; Marquina, J.; Ramirez, J.; Gonzales, A., E-mail: bertha.garcia@aliada.com.pe [ALIADA, Oncologia Integral, Av. Jose Galvez Barrenechea 1044, San Isidro, Lima 27 (Peru)

    2014-08-15

    The dosimetric controls that are realized to the patients in the Intensity-Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) techniques; are indispensable since allows in real time to verify the quantity of imparted dose to the patient, these controls should be carried out every time that will begin a treatment, because these techniques impart dose dynamically modulating the dose intensity and movements of the Multi leaf Collimator (MLC), for they exist different diodes devices prepared in spiral (3-D) and planar form (2-D); that allows to estimate the dose fluence in a certain area. Treatment studies for head and neck with IMRT were compared regarding the reading average carried out by the diodes in the corresponding areas, using the criteria of the gamma index like dose difference 3% or 3m m of distance for both diode arrangements, in the IMRT case was found in Arc-Check a minor difference of 3/3 for an average of 99.37% of read diodes in a correct way contrary to the reading obtained with the Map-Check 3/3 an average of difference of 96.19%; in IMRT the difference was lower due to different factors like sensibility of the diodes reading, resolution, diodes disposition, as well as the average reading of entrance and exit of the radiation beams. Within the parameters delivered by the diodes arrangement is considered the positioning correction for both acceptance indexes like the gamma factor and the Distance-to-agreement (Dta), the existent difference of reading in factor gamma and Dta fundamentally is the way in like they compare the dose distribution; the Gamma uses dose averages of high and low gradients and Dta use only averages of areas of high gradients between the nearest points giving the distance as a result among the distribution point and the nearest point what makes stricter. (Author)

  13. Applicability of refractometry for fast routine checking of hospital preparations.

    Science.gov (United States)

    Hendrickx, Stijn; Verón, Aurora Monteagudo; Van Schepdael, Ann; Adams, Erwin

    2016-04-30

    Quality control of hospital pharmacy formulations is of the utmost importance to ensure constant quality and to avoid potential mistakes before administration to the patient. In this study we investigated the applicability of refractometry as a fast, inexpensive and easy-to-use quality control measurement. Refractive indices (RI) of a multitude of different hospital formulations with varying concentrations of active compound were measured. The samples consisted of a number of binary aqueous solutions (one compound in water), complex aqueous solutions (multiple compounds in water or in a constant matrix), two suspensions and one emulsion. For all these formulations, linear regression analysis was performed, quality control limits determined and accuracy and repeatability were checked. Subsequently, actual hospital pharmacy samples were analyzed to check whether they were within the specified limits. For both binary and complex aqueous formulations, repeatability was good and a linear correlation for all samples could be observed on condition that the concentration of the active compound was sufficiently high. The refractometer was not sensitive enough for solutions of folic acid and levothyroxine, which had too low a concentration of active compound. Due to lack of homogeneity and light scattering, emulsions and suspensions do not seem suitable for quality control by refractometry. A mathematical equation was generated to predict the refractive index of an aqueous solution containing clonidine HCl as active compound. Values calculated from the equation were compared with measured values and deviations of all samples were found to be lower than 1.3%. In order to use refractometry in a hospital pharmacy for quality control of multicomponent samples, additional intermediate measurements would be required, to overcome the fact that refractometry is not compound specific. In conclusion, we found that refractometry could potentially be useful for daily, fast quality

  14. Development of Healthcare Kiosk for Checking Heart Health

    Directory of Open Access Journals (Sweden)

    Riyanto Sigit

    2016-04-01

    Full Text Available The main problem encountered nowadays in the health field, especially in health care is the growing number of population and the decreasing health facilities. In this regard, healthcare kiosk is used as an alternative to the health care facilities. Heart disease is a dangerous one which could threaten human life. Many people have died due to heart disease and the surgery itself is still very expensive. To analyze heart diseases, doctor usually takes a video of the heart movement using ultrasound equipment to distinguish between normal and abnormal case. The results of analysis vary depending on the accuracy and experience of each doctor so it is difficult to determine the actual situation. Therefore, a method using healthcare kiosk to check the heart health is needed to help doctor and improve the health care facilities. The aim of this research is to develop healthcare kiosk which can be used to check the heart health. This research method is divided into three main parts: firstly, preprocessing to clarify the quality of the image.In this section, the writers propose a Median High Boost Filter method which is a combined method of Median Filtering and High Boost Filtering. Secondly, segmentation is used to obtain local cavities of the heart. In this part, the writers propose using Triangle Equation that is a new method to be developed. Thirdly, classification using Partial Monte Carlo method and artificial neural network method; these methods are used to measure the area of the heart cavity and discover the possibility of cardiac abnormalities. Methods for detecting heart health are placed in the kiosk. Therefore, it is expected to facilitate and improve the healthcare facilities. Keywords: Healthcare kiosk, heart health, reprocessing, segmentation, classification.

  15. Analysis of DIRAC's behavior using model checking with process algebra

    Science.gov (United States)

    Remenska, Daniela; Templon, Jeff; Willemse, Tim; Bal, Henri; Verstoep, Kees; Fokkink, Wan; Charpentier, Philippe; Graciani Diaz, Ricardo; Lanciotti, Elisa; Roiser, Stefan; Ciba, Krzysztof

    2012-12-01

    DIRAC is the grid solution developed to support LHCb production activities as well as user data analysis. It consists of distributed services and agents delivering the workload to the grid resources. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check and possibly react to changes in the system state. Each agent's logic is relatively simple; the main complexity lies in their cooperation. Agents run concurrently, and collaborate using the databases as shared memory. The databases can be accessed directly by the agents if running locally or through a DIRAC service interface if necessary. This shared-memory model causes entities to occasionally get into inconsistent states. Tracing and fixing such problems becomes formidable due to the inherent parallelism present. We propose more rigorous methods to cope with this. Model checking is one such technique for analysis of an abstract model of a system. Unlike conventional testing, it allows full control over the parallel processes execution, and supports exhaustive state-space exploration. We used the mCRL2 language and toolset to model the behavior of two related DIRAC subsystems: the workload and storage management system. Based on process algebra, mCRL2 allows defining custom data types as well as functions over these. This makes it suitable for modeling the data manipulations made by DIRAC's agents. By visualizing the state space and replaying scenarios with the toolkit's simulator, we have detected race-conditions and deadlocks in these systems, which, in several cases, were confirmed to occur in the reality. Several properties of interest were formulated and verified with the tool. Our future direction is automating the translation from DIRAC to a formal model.

  16. Analysis of DIRAC's behavior using model checking with process algebra

    International Nuclear Information System (INIS)

    Remenska, Daniela; Templon, Jeff; Willemse, Tim; Bal, Henri; Verstoep, Kees; Fokkink, Wan; Charpentier, Philippe; Lanciotti, Elisa; Roiser, Stefan; Ciba, Krzysztof; Diaz, Ricardo Graciani

    2012-01-01

    DIRAC is the grid solution developed to support LHCb production activities as well as user data analysis. It consists of distributed services and agents delivering the workload to the grid resources. Services maintain database back-ends to store dynamic state information of entities such as jobs, queues, staging requests, etc. Agents use polling to check and possibly react to changes in the system state. Each agent's logic is relatively simple; the main complexity lies in their cooperation. Agents run concurrently, and collaborate using the databases as shared memory. The databases can be accessed directly by the agents if running locally or through a DIRAC service interface if necessary. This shared-memory model causes entities to occasionally get into inconsistent states. Tracing and fixing such problems becomes formidable due to the inherent parallelism present. We propose more rigorous methods to cope with this. Model checking is one such technique for analysis of an abstract model of a system. Unlike conventional testing, it allows full control over the parallel processes execution, and supports exhaustive state-space exploration. We used the mCRL2 language and toolset to model the behavior of two related DIRAC subsystems: the workload and storage management system. Based on process algebra, mCRL2 allows defining custom data types as well as functions over these. This makes it suitable for modeling the data manipulations made by DIRAC's agents. By visualizing the state space and replaying scenarios with the toolkit's simulator, we have detected race-conditions and deadlocks in these systems, which, in several cases, were confirmed to occur in the reality. Several properties of interest were formulated and verified with the tool. Our future direction is automating the translation from DIRAC to a formal model.

  17. Automated asphere centration testing with AspheroCheck UP

    Science.gov (United States)

    Hahne, F.; Langehanenberg, P.

    2017-10-01

    With aspheres being incorporated in optical designs across all industry fields, there is high demand for fast and flexible metrology solutions for aspheric lenses. While many systems support measuring the surface topography, the process is limited to a specific design or based on a time-consuming scanning process. Centration measurement with such systems requires additional probes or the inclusion of external reference surfaces in the measurement process. In this paper, we present AspheroCheck UP [1], a highly automated lens testing system based on the well-established AspheroCheck principle. The paraxial centering errors of both optical surfaces are measured in reflection using a focusing autocollimator. This centration measurement is combined with a fully motorized, non-contact distance sensor that measures the aspheric surface run-out. All three measurements can be performed in parallel during a single rotation of the sample, greatly reducing overall measurement time. The sensor can also be used for referencing to outer diameter, flange and/or interlock surfaces and even double-aspheric lenses. A five-axis motorized table enables the automatic alignment of the optical axis of the sample to the rotation axis. This significantly reduces setup time and allows for fully automatic testing without user interaction, ensuring both high measurement accuracy and high repeatability independent of the operator. A full cycle time of less than 1 minute including loading and unloading is possible, enabling applications in both R&D and production environments. In addition to supporting ISO and Q-type polynomial surfaces, the system supports most other rotationally symmetric surface types, including Fresnel and diffractive surfaces.

  18. Body checking and eating cognitions in Brazilian outpatients with eating disorders and non psychiatric controls.

    Science.gov (United States)

    Kachani, Adriana Trejger; Barroso, Lucia Pereira; Brasiliano, Silvia; Cordás, Táki Athanássios; Hochgraf, Patrícia Brunfentrinker

    2015-12-01

    Compare inadequate eating behaviors and their relationship to body checking in three groups: patients with anorexia nervosa (AN), patients with bulimia nervosa (BN) and a control group (C). Eighty three outpatients with eating disorders (ED) and 40 controls completed eating attitudes and body checking questionnaires. The overall relationship between the eating attitude and body checking was statistically significant in all three groups. The worse the eating attitude, the greater the body checking behavior. However, when we look at each group individually, the relationship was only statistically significant in the AN group (r=.354, p=0.020). The lower the desired weight and the worse the eating attitude, the more people check themselves, although in the presence of an ED the relationship between body checking and food restrictions is greater. In patients displaying the AN subgroup, body checking is also related to continued dietary control. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Design of Bidirectional Check Valve for Discrete Fluid Power Force System for Wave Energy Converters

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Pedersen, Henrik C.; Andersen, Torben Ole

    2014-01-01

    introduces large switching losses, especially when large pressure difference is present across the valves in the manifold. The current paper therefore focus on designing a bidirectional check valve for use in the switching manifold of the discrete force systems. The use of the bidirectional check valve...... enables passive force switching under minimal pressure difference, hence minimal energy loss. The bidirectional check valve is designed with a rated flow in the range of 1000L/min@5bar. The flow direction of the bidirectional check valve is set by the setting the pilot pressure. This paper presents...... a functionality test of a 125 L/min@5bar bidirectional check, leading to the design and modelling of a bidirectional check valve for ocean wave energy. It shows that a feasible bidirectional check valve may be configured by employing a multi-poppet topology for the main stage and utilising a 3/2 switching valve...

  20. Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries.

    Science.gov (United States)

    Blanchard, Joel W; Xie, Jia; El-Mecharrafie, Nadja; Gross, Simon; Lee, Sohyon; Lerner, Richard A; Baldwin, Kristin K

    2017-10-01

    The reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) is usually achieved by exogenous induction of transcription by factors acting in the nucleus. In contrast, during development, signaling pathways initiated at the membrane induce differentiation. The central idea of this study is to identify antibodies that can catalyze cellular de-differentiation and nuclear reprogramming by acting at the cell surface. We screen a lentiviral library encoding ∼100 million secreted and membrane-bound single-chain antibodies and identify antibodies that can replace either Sox2 and Myc (c-Myc) or Oct4 during reprogramming of mouse embryonic fibroblasts into iPSCs. We show that one Sox2-replacing antibody antagonizes the membrane-associated protein Basp1, thereby de-repressing nuclear factors WT1, Esrrb and Lin28a (Lin28) independent of Sox2. By manipulating this pathway, we identify three methods to generate iPSCs. Our results establish unbiased selection from autocrine combinatorial antibody libraries as a robust method to discover new biologics and uncover membrane-to-nucleus signaling pathways that regulate pluripotency and cell fate.

  1. Radioiodination of antibodies for tumor imaging

    International Nuclear Information System (INIS)

    Saha, G.B.

    1983-01-01

    In view of the great potential of radioiodinated antibody for the detection and treatment of cancer, the present article deals with the various techniques of radioiodination of antibody and their uses. Topics include methods of iodination of antibody, advantages and disadvantages of different methods, and effects of radioiodination on the antibody molecules with respect to their physiochemical and immunologic reactivity. In addition, the clinical usefulness of radioiodinated antibodies is discussed. (Auth.)

  2. Antibodies from plants for bionanomaterials.

    Science.gov (United States)

    Edgue, Gueven; Twyman, Richard M; Beiss, Veronique; Fischer, Rainer; Sack, Markus

    2017-11-01

    Antibodies are produced as part of the vertebrate adaptive immune response and are not naturally made by plants. However, antibody DNA sequences can be introduced into plants, and together with laboratory technologies that allow the design of antibodies recognizing any conceivable molecular structure, plants can be used as 'green factories' to produce any antibody at all. The advent of plant-based transient expression systems in particular allows the rapid, convenient, and safe production of antibodies, ranging from laboratory-scale expression to industrial-scale manufacturing. The key features of plant-based production include safety, speed, low cost, and convenience, allowing newcomers to rapidly master the technology and use it to its full advantage. Manufacturing in plants has recently achieved significant milestones and offers more than just an alternative to established microbial and mammalian cell platforms. The use of plants for product development in particular offers the power and flexibility to easily coexpress many different genes, allowing the plug-and-play construction of novel bionanomaterials, perfectly complementing existing approaches based on plant virus-like particles. As well as producing single antibodies for applications in medicine, agriculture, and industry, plants can be used to produce antibody-based supramolecular structures and scaffolds as a new generation of green bionanomaterials that promise a bright future based on clean and renewable nanotechnology applications. WIREs Nanomed Nanobiotechnol 2017, 9:e1462. doi: 10.1002/wnan.1462 For further resources related to this article, please visit the WIREs website. © 2017 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals, Inc.

  3. Antibody-Directed Phototherapy (ADP

    Directory of Open Access Journals (Sweden)

    M. Adil Butt

    2013-04-01

    Full Text Available Photodynamic therapy (PDT is a clinically-approved but rather under-exploited treatment modality for cancer and pre-cancerous superficial lesions. It utilises a cold laser or LED to activate a photochemical reaction between a light activated drug (photosensitiser-drug and oxygen to generate cytotoxic oxygen species. These free radical species damage cellular components leading to cell death. Despite its benefits, the complexity, limited potency and side effects of PDT have led to poor general usage. However, the research area is very active with an increasing understanding of PDT-related cell biology, photophysics and significant progress in molecular targeting of disease. Monoclonal antibody therapy is maturing and the next wave of antibody therapies includes antibody-drug conjugates (ADCs, which promise to be more potent and curable. These developments could lift antibody-directed phototherapy (ADP to success. ADP promises to increase specificity and potency and improve drug pharmacokinetics, thus delivering better PDT drugs whilst retaining its other benefits. Whole antibody conjugates with first generation ADP-drugs displayed problems with aggregation, poor pharmacokinetics and loss of immuno-reactivity. However, these early ADP-drugs still showed improved selectivity and potency. Improved PS-drug chemistry and a variety of conjugation strategies have led to improved ADP-drugs with retained antibody and PS-drug function. More recently, recombinant antibody fragments have been used to deliver ADP-drugs with superior drug loading, more favourable pharmacokinetics, enhanced potency and target cell selectivity. These improvements offer a promise of better quality PDT drugs.

  4. Antibody Validation by Western Blotting.

    Science.gov (United States)

    Signore, Michele; Manganelli, Valeria; Hodge, Alex

    2017-01-01

    Validation of antibodies is an integral part of translational research, particularly for biomarker discovery. Assaying the specificity of the reagent (antibody) and confirming the identity of the protein biomarker is of critical importance prior to implementing any biomarker in clinical studies, and the lack of such quality control tests may result in unexpected and/or misleading results.Antibody validation is the procedure in which a single antibody is thoroughly assayed for sensitivity and specificity. Although a plethora of commercial antibodies exist, antibody specificity must be extensively demonstrated using diverse complex biological samples, rather than purified recombinant proteins, prior to use in clinical translational research. In the simplest iteration, antibody specificity is determined by the presence of a single band in a complex biological sample, at the expected molecular weight, on a Western blot.To date, numerous Western blotting procedures are available, based on either manual or automated systems and spanning the spectrum of single blots to multiplex blots. X-ray film is still employed in many research laboratories, but digital imaging has become a gold standard in immunoblotting. The basic principles of Western blotting are (a) separation of protein mixtures by gel electrophoresis, (b) transfer of the proteins to a blot, (c) probing the blot for a protein or proteins of interest, and (d) subsequent detection of the protein by chemiluminescent, fluorescent, or colorimetric methods. This chapter focuses on the chemiluminescent detection of proteins using a manual Western blotting system and a vacuum-enhanced detection system (SNAP i.d.™, Millipore).

  5. Antibodies: an alternative for antibiotics?

    Science.gov (United States)

    Berghman, L R; Abi-Ghanem, D; Waghela, S D; Ricke, S C

    2005-04-01

    In 1967, the success of vaccination programs, combined with the seemingly unstoppable triumph of antibiotics, prompted the US Surgeon General to declare that "it was time to close the books on infectious diseases." We now know that the prediction was overly optimistic and that the fight against infectious diseases is here to stay. During the last 20 yr, infectious diseases have indeed made a staggering comeback for a variety of reasons, including resistance against existing antibiotics. As a consequence, several alternatives to antibiotics are currently being considered or reconsidered. Passive immunization (i.e., the administration of more or less pathogen-specific antibodies to the patient) prior to or after exposure to the disease-causing agent is one of those alternative strategies that was almost entirely abandoned with the introduction of chemical antibiotics but that is now gaining interest again. This review will discuss the early successes and limitations of passive immunization, formerly referred to as "serum therapy," the current use of antibody administration for prophylaxis or treatment of infectious diseases in agriculture, and, finally, recent developments in the field of antibody engineering and "molecular farming" of antibodies in various expression systems. Especially the potential of producing therapeutic antibodies in crops that are routine dietary components of farm animals, such as corn and soy beans, seems to hold promise for future application in the fight against infectious diseases.

  6. Influences on individuals' decisions to take up the offer of a health check: a qualitative study.

    Science.gov (United States)

    Burgess, Caroline; Wright, Alison J; Forster, Alice S; Dodhia, Hiten; Miller, Jane; Fuller, Frances; Cajeat, Eric; Gulliford, Martin C

    2015-12-01

    Health checks are promoted to evaluate individuals' risk of developing disease and to initiate health promotion and disease prevention interventions. The NHS Health Check is a cardiovascular risk assessment programme introduced in the UK aimed at preventing cardiovascular disease (CVD). Uptake of health checks is lower than anticipated. This study aimed to explore influences on people's decisions to take up the offer of a health check. Semi-structured interviews were conducted with people registered at four general practices in South London. The interview schedule was informed by the Theoretical Domains Framework. Data were analysed qualitatively using the Framework method using NVivo for data management. Twenty-seven participants invited for a health check were included in the study. Seventeen received the health check while 10 either did not attend or failed to complete the check. Five themes emerging from the data included a lack of awareness of the health check programme, beliefs about susceptibility to CVD, beliefs about civic responsibility, issues concerning access to appointments, and beliefs about the consequences of having a check. Health check programmes need to raise public awareness to ensure that people are informed about the objectives and nature of the programme in order to reach an informed decision about taking up the invitation. Emphasizing the benefits of prevention and early detection might encourage attendance in those who are reluctant to burden the public health-care systems. Extending outreach initiatives and increasing 'out of hours' provision at local community sites could facilitate access. © 2014 John Wiley & Sons Ltd.

  7. A portable mnemonic to facilitate checking for cognitive errors.

    Science.gov (United States)

    Chew, Keng Sheng; van Merriënboer, Jeroen; Durning, Steven J

    2016-09-17

    Although a clinician may have the intention of carrying out strategies to reduce cognitive errors, this intention may not be realized especially under heavy workload situations or following a period of interruptions. Implementing strategies to reduce cognitive errors in clinical setting may be facilitated by a portable mnemonic in the form of a checklist. A 2-stage approach using both qualitative and quantitative methods was used in the development and evaluation of a mnemonic checklist. In the development stage, a focus-driven literature search and a face-to-face discussion with a content expert in cognitive errors were carried out. Categories of cognitive errors addressed and represented in the checklist were identified. In the judgment stage, the face and content validity of the categories of cognitive errors represented in the checklist were determined. This was accomplished through coding responses of a panel of experts in cognitive errors. From the development stage, a preliminary version of the checklist in the form of four questions represented by four specific letters was developed. The letter 'T' in the TWED checklist stands for 'Threat' (i.e., 'is there any life or limb threat that I need to rule out in this patient?'), 'W' for 'Wrong/What else' (i.e., 'What if I am wrong? What else could it be?'), 'E' for 'evidences' (i.e., 'Do I have sufficient evidences to support or exclude this diagnosis?'), and 'D' for 'dispositional factors' (i.e., 'is there any dispositional factor that influence my decision'). In the judgment stage, the content validity of most categories of cognitive errors addressed in the checklist was rated highly in terms of their relevance and representativeness (with modified kappa values ranging from 0.65 to 1.0). Based on the coding of responses from seven experts, this checklist was shown to be sufficiently comprehensive to activate the implementation intention of checking cognitive errors. The TWED checklist is a portable mnemonic

  8. Antibody profiling sensitivity through increased reporter antibody layering

    Energy Technology Data Exchange (ETDEWEB)

    Apel, William A; Thompson, Vicki S

    2013-02-26

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  9. Antibody profiling sensitivity through increased reporter antibody layering

    International Nuclear Information System (INIS)

    Apel, William A.; Thompson, Vickie S.

    2013-01-01

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  10. Antibody profiling sensitivity through increased reporter antibody layering

    Energy Technology Data Exchange (ETDEWEB)

    Apel, William A.; Thompson, Vicki S.

    2013-02-26

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  11. Antibody profiling sensitivity through increased reporter antibody layering

    Energy Technology Data Exchange (ETDEWEB)

    Apel, William A.; Thompson, Vicki S

    2010-04-13

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  12. Antibody profiling sensitivity through increased reporter antibody layering

    Energy Technology Data Exchange (ETDEWEB)

    Apel, William A.; Thompson, Vicki S.

    2017-03-28

    A method for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method comprises attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to the antigens in the array to form immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, to form an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  13. Consistency Checking of Safety and Availability in Access Control

    Science.gov (United States)

    Li, Ruixuan; Lu, Jianfeng; Lu, Zhengding; Ma, Xiaopu

    The safety and availability policies are very important in an access control system for ensuring security and success when performing a certain task. However, conflicts may arise between safety and availability policies due to their opposite focuses. In this paper, we address the problem of consistency checking for safety and availability policies, especially for the co-existence of static separation-of-duty (SSoD) policies with availability policies, which determines whether there exists an access control state that satisfies all of these policies. We present criteria for determining consistency with a number of special cases, and show that the general case and partial subcases of the problem are intractable (NP-hard) and in the Polynomial Hierarchy NPNP. We design an algorithm to efficiently solve the nontrivial size instances for the intractable cases of the problem. The running example shows the validity of the proposed algorithm. The investigation will help the security officer to specify reasonable access control policies when both safety and availability policies coexist.

  14. Astronaut Edwin E. Aldrin Undergoes Communications Systems Final Check

    Science.gov (United States)

    1969-01-01

    Dunned in his space suit, Lunar Module pilot Edwin E. Aldrin, Jr. does a final check of his communications system before the boarding of the Apollo 11 mission. Launched via a Saturn V launch vehicle, the first manned lunar mission launched from the Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. The 3-man crew aboard the flight consisted of astronauts Aldrin; Michael Collins, Command Module (CM) pilot; and Neil Armstrong, mission commander. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. Meanwhile, astronaut Collins piloted the CM in a parking orbit around the Moon. During a 2½ hour surface exploration, the crew collected 47 pounds of lunar surface material which was returned to Earth for analysis. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  15. The error performance analysis over cyclic redundancy check codes

    Science.gov (United States)

    Yoon, Hee B.

    1991-06-01

    The burst error is generated in digital communication networks by various unpredictable conditions, which occur at high error rates, for short durations, and can impact services. To completely describe a burst error one has to know the bit pattern. This is impossible in practice on working systems. Therefore, under the memoryless binary symmetric channel (MBSC) assumptions, the performance evaluation or estimation schemes for digital signal 1 (DS1) transmission systems carrying live traffic is an interesting and important problem. This study will present some analytical methods, leading to efficient detecting algorithms of burst error using cyclic redundancy check (CRC) code. The definition of burst error is introduced using three different models. Among the three burst error models, the mathematical model is used in this study. The probability density function, function(b) of burst error of length b is proposed. The performance of CRC-n codes is evaluated and analyzed using function(b) through the use of a computer simulation model within CRC block burst error. The simulation result shows that the mean block burst error tends to approach the pattern of the burst error which random bit errors generate.

  16. Heuristics for Hierarchical Partitioning with Application to Model Checking

    DEFF Research Database (Denmark)

    Möller, Michael Oliver; Alur, Rajeev

    2001-01-01

    Given a collection of connected components, it is often desired to cluster together parts of strong correspondence, yielding a hierarchical structure. We address the automation of this process and apply heuristics to battle the combinatorial and computational complexity. We define a cost function...... studies. A longer version of this paper is available as technical report BRICS Research Series RS-00-21. Basic Research in Computer Science, Center of the Danish National Research Foundation....... function. We argue for a heuristic function based on four criteria: the number of enclosed connections, the number of components, the number of touched connections and the depth of the structure. We report on an application in the context of formal verification, where our algorithm serves as a preprocessor...... for a temporal scaling technique, called “Next” heuristic [2]. The latter is applicable in reachability analysis and is included in a recent version of the Mocha model checking tool. We demonstrate performance and benefits of our method and use an asynchronous parity computer and an opinion poll protocol as case...

  17. A formalism for independent checking of Gamma Knife dose calculations

    International Nuclear Information System (INIS)

    Tsai Jensan; Engler, Mark J.; Rivard, Mark J.; Mahajan, Anita; Borden, Jonathan A.; Zheng Zhen

    2001-01-01

    For stereotactic radiosurgery using the Leksell Gamma Knife system, it is important to perform a pre-treatment verification of the maximum dose calculated with the Leksell GammaPlan[reg] (D LGP ) stereotactic radiosurgery system. This verification can be incorporated as part of a routine quality assurance (QA) procedure to minimize the chance of a hazardous overdose. To implement this procedure, a formalism has been developed to calculate the dose D CAL (X,Y,Z,d av ,t) using the following parameters: average target depth (d av ), coordinates (X,Y,Z) of the maximum dose location or any other dose point(s) to be verified, 3-dimensional (3-dim) beam profiles or off-center-ratios (OCR) of the four helmets, helmet size i, output factor O i , plug factor P i , each shot j coordinates (x,y,z) i,j , and shot treatment time (t i,j ). The average depth of the target d av was obtained either from MRI/CT images or ruler measurements of the Gamma Knife Bubble Head Frame. D CAL and D LGP were then compared to evaluate the accuracy of this independent calculation. The proposed calculation for an independent check of D LGP has been demonstrated to be accurate and reliable, and thus serves as a QA tool for Gamma Knife stereotactic radiosurgery

  18. Transformation of UML Behavioral Diagrams to Support Software Model Checking

    Directory of Open Access Journals (Sweden)

    Luciana Brasil Rebelo dos Santos

    2014-04-01

    Full Text Available Unified Modeling Language (UML is currently accepted as the standard for modeling (object-oriented software, and its use is increasing in the aerospace industry. Verification and Validation of complex software developed according to UML is not trivial due to complexity of the software itself, and the several different UML models/diagrams that can be used to model behavior and structure of the software. This paper presents an approach to transform up to three different UML behavioral diagrams (sequence, behavioral state machines, and activity into a single Transition System to support Model Checking of software developed in accordance with UML. In our approach, properties are formalized based on use case descriptions. The transformation is done for the NuSMV model checker, but we see the possibility in using other model checkers, such as SPIN. The main contribution of our work is the transformation of a non-formal language (UML to a formal language (language of the NuSMV model checker towards a greater adoption in practice of formal methods in software development.

  19. Co-Check: Collaborative Outsourced Data Auditing in Multicloud Environment

    Directory of Open Access Journals (Sweden)

    Jian Mao

    2017-01-01

    Full Text Available With the increasing demand for ubiquitous connectivity, wireless technology has significantly improved our daily lives. Meanwhile, together with cloud-computing technology (e.g., cloud storage services and big data processing, new wireless networking technology becomes the foundation infrastructure of emerging communication networks. Particularly, cloud storage has been widely used in services, such as data outsourcing and resource sharing, among the heterogeneous wireless environments because of its convenience, low cost, and flexibility. However, users/clients lose the physical control of their data after outsourcing. Consequently, ensuring the integrity of the outsourced data becomes an important security requirement of cloud storage applications. In this paper, we present Co-Check, a collaborative multicloud data integrity audition scheme, which is based on BLS (Boneh-Lynn-Shacham signature and homomorphic tags. According to the proposed scheme, clients can audit their outsourced data in a one-round challenge-response interaction with low performance overhead. Our scheme also supports dynamic data maintenance. The theoretical analysis and experiment results illustrate that our scheme is provably secure and efficient.

  20. Availability of the OGC geoprocessing standard: March 2011 reality check

    Science.gov (United States)

    Lopez-Pellicer, Francisco J.; Rentería-Agualimpia, Walter; Béjar, Rubén; Muro-Medrano, Pedro R.; Zarazaga-Soria, F. Javier

    2012-10-01

    This paper presents an investigation about the servers available in March 2011 conforming to the Web Processing Service interface specification published by the geospatial standards organization Open Geospatial Consortium (OGC) in 2007. This interface specification gives support to standard Web-based geoprocessing. The data used in this research were collected using a focused crawler configured for finding OGC Web services. The research goals are (i) to provide a reality check of the availability of Web Processing Service servers, (ii) to provide quantitative data about the use of different features defined in the standard that are relevant for a scalable Geoprocessing Web (e.g. long-running processes, Web-accessible data outputs), and (iii) to test if the advances in the use of search engines and focused crawlers for finding Web services can be applied for finding geoscience processing systems. Research results show the feasibility of the discovery approach and provide data about the implementation of the Web Processing Service specification. These results also show extensive use of features related to scalability, except for those related to technical and semantic interoperability.

  1. Online integrity and authentication checking for Quran electronic versions

    Directory of Open Access Journals (Sweden)

    Izzat Alsmadi

    2017-01-01

    Full Text Available The ability to control data and information through the Internet can be challenging. Preliminary analysis showed that some tampering and forgery may occur to some words of the Quran in the electronic versions that span the Internet. Such small modifications may not be noticed by public audience. The holy book of Quran includes a unique feature in that its worldwide copies are all identical. The 114 chapters (Suras and all their verses and words are preserved in the exact form. As such, we designed and evaluated a model and a tool to evaluate the integrity of the wording in the e-versions of the Quran through generating a Meta data related to all words in the Quran preserving the counts and locations. Such Meta data can be used in the same way hash algorithms are used in security to check the integrity of a disk and its data files where any small change in the data will result in a different hash value. We conducted several experiments to evaluate the different parameters and challenges that can impact the automatic authentication process of Quranic verses based on information retrieval and hashing algorithms.

  2. Astronaut Neil A. Armstrong Undergoes Communications Systems Final Check

    Science.gov (United States)

    1969-01-01

    Dunned in his space suit, mission commander Neil A. Armstrong does a final check of his communications system before before the boarding of the Apollo 11 mission. Launched via a Saturn V launch vehicle, the first manned lunar mission launched from the Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. The 3-man crew aboard the flight consisted of astronauts Armstrong; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin, Jr., Lunar Module (LM) Pilot. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. Meanwhile, astronaut Collins piloted the CM in a parking orbit around the Moon. During a 2½ hour surface exploration, the crew collected 47 pounds of lunar surface material which was returned to Earth for analysis. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  3. Grab Windows training opportunities; check CERN Windows roadmap!

    CERN Multimedia

    IT Department

    2011-01-01

    CERN Operating Systems and Information Services group (IT-OIS) actively monitors market trends to check how new software products correspond to CERN needs. In the Windows world, Windows 7 has been a big hit, with over 1500 Windows 7 PCs within less than a year since its support was introduced at CERN. No wonder: Windows XP is nearly 10 years old and is steadily approaching the end of its life-cycle. At CERN, support for Windows XP will stop at the end of December 2012. Compared to Vista, Windows 7 has the same basic hardware requirements, but offers higher performance, so the decision to upgrade is rather straightforward. CERN support for Vista will end in June 2011. In the world of Microsoft Office, version 2007 offers better integration with the central services than the older version 2003. Progressive upgrade from 2003 to 2007 is planned to finish in September 2011, but users are encouraged to pro-actively upgrade at their convenience. Please note that Office 2007 brings an important change in the area of ...

  4. Experimental investigation of the check valve behaviour when the flow is reversing

    Directory of Open Access Journals (Sweden)

    Himr D.

    2017-01-01

    Full Text Available Check valve in a pipeline is supposed to prevent the reverse flow and to allow the flow in the positive direction. The construction of check valves follows these requirements, but the check valve must not cause pressure pulsations in transients. It means when the fluid is accelerating or decelerating. The article describes an experimental investigation of a swing check valve when the flow is changing its direction. The check valve was placed in an experimental circuit, where the pressure on the upstream and downstream side of the valve was measured and the current value of flow rate was determined. The goal was to simulate conditions in the real system, where the check valve slam had been observed.

  5. Diversity and ambivalence in general practitioners' attitudes towards preventive health checks - a qualitative study

    DEFF Research Database (Denmark)

    Søndergaard, Anne; Christensen, Bo; Maindal, Helle Terkildsen

    2012-01-01

    .The purpose of our study is to describe GPs' attitudes towards and concerns about providing preventive health checks and to describe their experiences with the health checks that they provide in daily practice. METHODS: A qualitative descriptive study was conducted based on three semi-structured focus group...... interviews with 16 GPs from Central Region, Denmark. The focus group interviews took place at the Department of Public Health, Section for General Practice, Aarhus University in November 2010. RESULTS: We found that the participating GPs all conducted some kind of preventive health checks, but also...... concerned whether the health checks would benefit the "right" patients. The GPs felt a need for further documentation of the benefits for the patients before a possible future implementation of systematic health checks. Some GPs found that health checks could be performed in other settings than general...

  6. Hu and Yo antibodies have heterogeneous avidity.

    Science.gov (United States)

    Totland, Cecilie; Aarseth, Jan; Vedeler, Christian

    2007-04-01

    Onconeural antibodies such as anti-Hu and anti-Yo may be important in the pathogenesis of paraneoplastic neurological syndromes. The avidity of these antibodies is not known. In this study, we compared the avidity of Hu and Yo antibodies both at single time points and over a time range of 2 months to 6 years. The avidity of Yo and Hu antibodies differed among the patients, but anti-Yo generally had higher avidity than anti-Hu. Whether Yo antibodies are more pathogenic than Hu antibodies are presently unknown.

  7. General health checks in adults for reducing morbidity and mortality from disease

    DEFF Research Database (Denmark)

    Krogsbøll, Lasse T; Jørgensen, Karsten Juhl; Grønhøj Larsen, Christian

    2012-01-01

    General health checks are common elements of health care in some countries. These aim to detect disease and risk factors for disease with the purpose of reducing morbidity and mortality. Most of the commonly used screening tests offered in general health checks have been incompletely studied. Also......, screening leads to increased use of diagnostic and therapeutic interventions, which can be harmful as well as beneficial. It is, therefore, important to assess whether general health checks do more good than harm....

  8. Autonomic Recovery: HyperCheck: A Hardware-Assisted Integrity Monitor

    Science.gov (United States)

    2013-08-01

    devices. To evaluate the va- lidity and performance of our approach, we implemented two prototypes for HyperCheck. HyperCheck-I uses QEMU [3] – a fully...and no modification to the installed software. 2. Implemented two prototypes: one based on QEMU and the other based on the real hardware. The latter...HyperCheck performs anomaly detection and thus can identify a larger class of software rootkits. Flicker [23] uses a TPM based method to provide a

  9. SU-D-BRD-03: Improving Plan Quality with Automation of Treatment Plan Checks

    Energy Technology Data Exchange (ETDEWEB)

    Covington, E; Younge, K; Chen, X; Lee, C; Matuszak, M; Kessler, M; Acosta, E; Orow, A; Filpansick, S; Moran, J [University of Michigan Hospital and Health System, Ann Arbor, MI (United States); Keranen, W [Varian Medical Systems, Palo Alto, CA (United States)

    2015-06-15

    Purpose: To evaluate the effectiveness of an automated plan check tool to improve first-time plan quality as well as standardize and document performance of physics plan checks. Methods: The Plan Checker Tool (PCT) uses the Eclipse Scripting API to check and compare data from the treatment planning system (TPS) and treatment management system (TMS). PCT was created to improve first-time plan quality, reduce patient delays, increase efficiency of our electronic workflow, and to standardize and partially automate plan checks in the TPS. A framework was developed which can be configured with different reference values and types of checks. One example is the prescribed dose check where PCT flags the user when the planned dose and the prescribed dose disagree. PCT includes a comprehensive checklist of automated and manual checks that are documented when performed by the user. A PDF report is created and automatically uploaded into the TMS. Prior to and during PCT development, errors caught during plan checks and also patient delays were tracked in order to prioritize which checks should be automated. The most common and significant errors were determined. Results: Nineteen of 33 checklist items were automated with data extracted with the PCT. These include checks for prescription, reference point and machine scheduling errors which are three of the top six causes of patient delays related to physics and dosimetry. Since the clinical roll-out, no delays have been due to errors that are automatically flagged by the PCT. Development continues to automate the remaining checks. Conclusion: With PCT, 57% of the physics plan checklist has been partially or fully automated. Treatment delays have declined since release of the PCT for clinical use. By tracking delays and errors, we have been able to measure the effectiveness of automating checks and are using this information to prioritize future development. This project was supported in part by P01CA059827.

  10. SU-D-BRD-03: Improving Plan Quality with Automation of Treatment Plan Checks

    International Nuclear Information System (INIS)

    Covington, E; Younge, K; Chen, X; Lee, C; Matuszak, M; Kessler, M; Acosta, E; Orow, A; Filpansick, S; Moran, J; Keranen, W

    2015-01-01

    Purpose: To evaluate the effectiveness of an automated plan check tool to improve first-time plan quality as well as standardize and document performance of physics plan checks. Methods: The Plan Checker Tool (PCT) uses the Eclipse Scripting API to check and compare data from the treatment planning system (TPS) and treatment management system (TMS). PCT was created to improve first-time plan quality, reduce patient delays, increase efficiency of our electronic workflow, and to standardize and partially automate plan checks in the TPS. A framework was developed which can be configured with different reference values and types of checks. One example is the prescribed dose check where PCT flags the user when the planned dose and the prescribed dose disagree. PCT includes a comprehensive checklist of automated and manual checks that are documented when performed by the user. A PDF report is created and automatically uploaded into the TMS. Prior to and during PCT development, errors caught during plan checks and also patient delays were tracked in order to prioritize which checks should be automated. The most common and significant errors were determined. Results: Nineteen of 33 checklist items were automated with data extracted with the PCT. These include checks for prescription, reference point and machine scheduling errors which are three of the top six causes of patient delays related to physics and dosimetry. Since the clinical roll-out, no delays have been due to errors that are automatically flagged by the PCT. Development continues to automate the remaining checks. Conclusion: With PCT, 57% of the physics plan checklist has been partially or fully automated. Treatment delays have declined since release of the PCT for clinical use. By tracking delays and errors, we have been able to measure the effectiveness of automating checks and are using this information to prioritize future development. This project was supported in part by P01CA059827

  11. 'Check it out!' Decision-making of vulnerable groups about participation in a two-stage cardiometabolic health check: a qualitative study

    NARCIS (Netherlands)

    Groenenberg, I.; Crone, M.R.; Dijk, S. van; Gebhardt, W.A.; Meftah, J. Ben; Middelkoop, B.J.C.; Stiggelbout, A.M.; Assendelft, W.J.

    2015-01-01

    OBJECTIVE: Exploring determinants influencing vulnerable groups regarding (non-) participation in the Dutch two-stage cardiometabolic health check, comprising a health risk assessment (HRA) and prevention consultations (PCs) for high-risk individuals. METHODS: Qualitative study comprising 21 focus

  12. Overview of Prevention for Water Hammer by Check Valve Action in Nuclear Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dayong; Yoon, Hyungi; Seo, Kyoungwoo; Kim, Seonhoon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Water hammer can cause serious damage to pumping system and unexpected system pressure rise in the pipeline. In nuclear reactor, water hammer can influence on the integrity of safety related system. Water hammer in nuclear reactor have been caused by voiding in normally water-filled lines, steam condensation line containing both steam and water, as well as by rapid check valve action. Therefore, this study focuses on the water hammer by check valve among the sources of water hammer occurrence and suggests proper methodology for check valve type selection against water hammer. This study focuses on the water hammer by check valve action among the sources of water hammer occurrence and suggests proper methodology for check valve type selection against water hammer. If the inadvertent pump trip or pipe rupture in high velocity and pressure pipe is predicted, the fast response check valve such as tiled disc, dual disc and nozzle check valve should be installed in the system. If the inadvertent pump trip or pipe rupture in very high velocity and pressure pipe and excessively large revered flow velocity are predicted, the very slowly closing check valve such as controlled closure check valve should be installed in the system.

  13. Efficient Multi-Valued Bounded Model Checking for LTL over Quasi-Boolean Algebras

    OpenAIRE

    Andrade, Jefferson O.; Kameyama, Yukiyoshi

    2012-01-01

    Multi-valued Model Checking extends classical, two-valued model checking to multi-valued logic such as Quasi-Boolean logic. The added expressivity is useful in dealing with such concepts as incompleteness and uncertainty in target systems, while it comes with the cost of time and space. Chechik and others proposed an efficient reduction from multi-valued model checking problems to two-valued ones, but to the authors' knowledge, no study was done for multi-valued bounded model checking. In thi...

  14. A novel cognitive intervention for compulsive checking: Targeting maladaptive beliefs about memory.

    Science.gov (United States)

    Alcolado, Gillian M; Radomsky, Adam S

    2016-12-01

    Compulsive checking is one of the most common symptoms of obsessive-compulsive disorder (OCD). Recently it has been proposed that those who check compulsively may believe their memory is poor, rather than having an actual memory impairment. The current study sought to develop and assess a brief cognitive intervention focused on improving maladaptive beliefs about memory, as they pertain to both checking symptoms and memory performance. Participants (N = 24) with a diagnosis of OCD and clinical levels of checking symptomatology were randomly assigned either to receive two weekly 1-hour therapy sessions or to self-monitor during a similar waitlist period. Time spent checking, checking symptoms, maladaptive beliefs about memory, and visuospatial memory were assessed both pre- and post-treatment/waitlist. Results showed that compared to the waitlist condition, individuals in the treatment condition displayed significant decreases in their maladaptive beliefs about memory and checking symptoms from pre- to post-intervention. They also exhibited increased recall performance on a measure of visuospatial memory. Changes in beliefs about memory were predictors of reduced post-intervention checking, but were not predictive of increased post-intervention memory scores. The lack of long term follow-up data and use of a waitlist control leave questions about the stability and specificity of the intervention. Findings provide preliminary evidence that strategies targeting beliefs about memory may be worthy of inclusion in cognitive-behavioural approaches to treating compulsive checking. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Overview of Prevention for Water Hammer by Check Valve Action in Nuclear Reactor

    International Nuclear Information System (INIS)

    Kim, Dayong; Yoon, Hyungi; Seo, Kyoungwoo; Kim, Seonhoon

    2016-01-01

    Water hammer can cause serious damage to pumping system and unexpected system pressure rise in the pipeline. In nuclear reactor, water hammer can influence on the integrity of safety related system. Water hammer in nuclear reactor have been caused by voiding in normally water-filled lines, steam condensation line containing both steam and water, as well as by rapid check valve action. Therefore, this study focuses on the water hammer by check valve among the sources of water hammer occurrence and suggests proper methodology for check valve type selection against water hammer. This study focuses on the water hammer by check valve action among the sources of water hammer occurrence and suggests proper methodology for check valve type selection against water hammer. If the inadvertent pump trip or pipe rupture in high velocity and pressure pipe is predicted, the fast response check valve such as tiled disc, dual disc and nozzle check valve should be installed in the system. If the inadvertent pump trip or pipe rupture in very high velocity and pressure pipe and excessively large revered flow velocity are predicted, the very slowly closing check valve such as controlled closure check valve should be installed in the system

  16. 9 CFR 113.452 - Erysipelothrix Rhusiopathiae Antibody.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD... Antibody is a specific antibody product containing antibodies directed against one or more somatic antigens...

  17. Monoclonal antibodies to Treponema Pallidum.

    NARCIS (Netherlands)

    H.J.M. van de Donk; J.D.A. van Embden; M.F. van Olderen; A.D.M.E. Osterhaus (Albert); J.C. de Jong (Jan)

    1984-01-01

    textabstractThree successive fusions of mouse myeloma cells and spleen lymphocytes of a mouse immunized with Treponema Pallidum resulted in one hybridoma producing anti T. pallidum antibodies for each fusion. The mice were immunized with live pallidum cells respectively 1, 3 and 5 months before

  18. Cross-checking different sources of mobility information.

    Directory of Open Access Journals (Sweden)

    Maxime Lenormand

    Full Text Available The pervasive use of new mobile devices has allowed a better characterization in space and time of human concentrations and mobility in general. Besides its theoretical interest, describing mobility is of great importance for a number of practical applications ranging from the forecast of disease spreading to the design of new spaces in urban environments. While classical data sources, such as surveys or census, have a limited level of geographical resolution (e.g., districts, municipalities, counties are typically used or are restricted to generic workdays or weekends, the data coming from mobile devices can be precisely located both in time and space. Most previous works have used a single data source to study human mobility patterns. Here we perform instead a cross-check analysis by comparing results obtained with data collected from three different sources: Twitter, census, and cell phones. The analysis is focused on the urban areas of Barcelona and Madrid, for which data of the three types is available. We assess the correlation between the datasets on different aspects: the spatial distribution of people concentration, the temporal evolution of people density, and the mobility patterns of individuals. Our results show that the three data sources are providing comparable information. Even though the representativeness of Twitter geolocated data is lower than that of mobile phone and census data, the correlations between the population density profiles and mobility patterns detected by the three datasets are close to one in a grid with cells of 2×2 and 1×1 square kilometers. This level of correlation supports the feasibility of interchanging the three data sources at the spatio-temporal scales considered.

  19. Radioimmunological determination of growth hormone antibodies

    International Nuclear Information System (INIS)

    Kracmar, P.; Hnikova, O.

    1979-01-01

    The method is based on the assumption of the presence of antibodies in the serum of the patient and the formation of the complex antibody-tracer ( 125 I-STH). For separation the principle is used of two antibodies and subsequent ultrafiltration with membrane ultrafilters. Clinical experience, reproducibility and the procedure recommended for simple monitoring and the determination of the amount of antibodies in the serum of patients are presented. (author)

  20. Antibody therapeutics - the evolving patent landscape.

    Science.gov (United States)

    Petering, Jenny; McManamny, Patrick; Honeyman, Jane

    2011-09-01

    The antibody patent landscape has evolved dramatically over the past 30 years, particularly in areas of technology relating to antibody modification to reduce immunogenicity in humans or improve antibody function. In some cases antibody techniques that were developed in the 1980s are still the subject of patent protection in the United States or Canada. Copyright © 2011 Elsevier B.V. All rights reserved.

  1. Antibodies against chromosomal beta-lactamase

    DEFF Research Database (Denmark)

    Giwercman, B; Rasmussen, J W; Ciofu, Oana

    1994-01-01

    A murine monoclonal anti-chromosomal beta-lactamase antibody was developed and an immunoblotting technique was used to study the presence of serum and sputum antibodies against Pseudomonas aeruginosa chromosomal group 1 beta-lactamase in patients with cystic fibrosis (CF). The serum antibody resp...... against the infection. On the other hand, immune complexes between the beta-lactamase and corresponding antibodies could play a role in the pathogenesis of bronchopulmonary injury in CF by mediating hyperimmune reactions....

  2. Radioimmunoassay method for detection of gonorrhea antibodies

    International Nuclear Information System (INIS)

    1975-01-01

    A novel radioimmunoassay for the detection of gonorrhea antibodies in serum is described. A radionuclide is bound to gonorrhea antigens produced by a growth culture. In the presence of gonorrhea antibodies in the serum, an antigen-antibody conjugate is formed, the concentration of which can be measured with conventional radiometric methods. The radioimmunoassay is highly specific

  3. Antibodies Against Melanin | Wassermann | South African Medical ...

    African Journals Online (AJOL)

    This study reports on unsuccessful attempts to produce antibodies against melanoprotein in rabbits. Available evidence suggests antibodies against melanocytes in the aetiology of vitiligo, but there is no convincing evidence for antibodies against melanin per se. It is suggested that the demonstration of antibodif's against ...

  4. Detection of antibodies to co-trimoxazole (preservative drug interfering with routine red cell antibody screening

    Directory of Open Access Journals (Sweden)

    Deepti Sachan

    2018-01-01

    Full Text Available Drug-dependent antibodies can rarely cause interference in pretransfusion antibody screening. The diluents for commercial reagent red blood cells contain different antibiotics, such as chloramphenicol, neomycin sulfate, and gentamycin as a preservative. The presence of antibodies to a given drug in patient may lead to positive results when performing antibody identification. We present a rare case of detection of anti-co-trimoxazole antibody during routine antibody screening in a female patient undergoing neurosurgery. These antibodies mimicked as antibody against high-frequency red cell antigens reacting in both saline phase as well as antiglobulin phase. Anti-co-trimoxazole antibody was confirmed by repeating antibody screen using reagent red cells of different manufacturers with and without co-trimoxazole drug as preservative as well as using washed red cell panels. There were no associated clinical or laboratory evidence of hemolysis.

  5. 26 CFR 301.6311-1 - Payment by check or money order.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Payment by check or money order. 301.6311-1... by check or money order. (a) Authority to receive—(1) In general. (i) District directors, Service... District of Columbia, or any possession of the United States, or money orders in payment for internal...

  6. 27 CFR 70.61 - Payment by check or money order.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Payment by check or money... Collection of Excise and Special (Occupational) Tax Receipt of Payment § 70.61 Payment by check or money... State, Territory, or possession of the United States, or money orders in payment for internal revenue...

  7. 10 CFR 73.28 - Security background checks for secure transfer of nuclear materials.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Security background checks for secure transfer of nuclear... PLANTS AND MATERIALS Physical Protection of Special Nuclear Material in Transit § 73.28 Security background checks for secure transfer of nuclear materials. Licensees are excepted from the security...

  8. Fast Collision Checking: From Single Robots to Multi-Robot Teams

    OpenAIRE

    Bialkowski, Joshua; Otte, Michael; Frazzoli, Emilio

    2013-01-01

    We examine three different algorithms that enable the collision certificate method from [Bialkowski, et al.] to handle the case of a centralized multi-robot team. By taking advantage of symmetries in the configuration space of multi-robot teams, our methods can significantly reduce the number of collision checks vs. both [Bialkowski, et al.] and standard collision checking implementations.

  9. AUTOMATED HOTEL CHECK-IN SERTA DAMPAKNYA PADA TENAGA KERJA LOKAL

    Directory of Open Access Journals (Sweden)

    Ni Gusti Nyoman Suci Murni

    2017-10-01

    Full Text Available The tourism sector is one of the most heavily influenced sectors of information technology. Hotels that are a component of tourism cannot be separated from these influences, especially in information services, room reservations, check-in / check-out service, and other services. With the sophistication of information technology, everyone can access any information, from anywhere; at a very cheap price even every country provides free facilities for that purpose. This study uses qualitative methods where the data source obtained by looking for some libraries related to self check-in. The results show that there are some differences that applied between the check-in manual and self check-in, and the impact caused by the application of self check-in. The positive impact of self check-in are speeding up the check-in process, saving payrolls, simplifying services, simplifying reporting, and saving time. While the negative impacts such as reducing employment in developing countries, reducing social communication / human touch, reducing the understanding of cross cultural understanding, allowing the occurrence of crime (cyber crime as well as very expensive initial cost.

  10. 25 CFR 36.100 - Are there minimum requirements for student attendance checks?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Are there minimum requirements for student attendance... MINIMUM ACADEMIC STANDARDS FOR THE BASIC EDUCATION OF INDIAN CHILDREN AND NATIONAL CRITERIA FOR DORMITORY... attendance checks? Yes, there are minimum requirements for student attendance checks as follows: (a) All...

  11. Using Canonical Forms for Isomorphism Reduction in Graph-based Model Checking

    NARCIS (Netherlands)

    Kant, Gijs

    Graph isomorphism checking can be used in graph-based model checking to achieve symmetry reduction. Instead of one-to-one comparing the graph representations of states, canonical forms of state graphs can be computed. These canonical forms can be used to store and compare states. However, computing

  12. First-order dominance: stronger characterization and a bivariate checking algorithm

    DEFF Research Database (Denmark)

    Range, Troels Martin; Østerdal, Lars Peter Raahave

    2018-01-01

    distributions. Utilizing that this problem can be formulated as a transportation problem with a special structure, we provide a stronger characterization of multivariate first-order dominance and develop a linear time complexity checking algorithm for the bivariate case. We illustrate the use of the checking...

  13. Creating Büchi automata for multi-valued model checking

    NARCIS (Netherlands)

    Vijzelaar, Stefan J.J.; Fokkink, Wan J.

    2017-01-01

    In explicit state model checking of linear temporal logic properties, a Büchi automaton encodes a temporal property. It interleaves with a Kripke model to form a state space, which is searched for counterexamples. Multi-valued model checking considers additional truth values beyond the Boolean true

  14. 78 FR 2214 - Enhanced Weapons, Firearms Background Checks, and Security Event Notifications

    Science.gov (United States)

    2013-01-10

    ... ML110480470 of Nuclear Energy Institute, on the proposed ``Enhanced Weapons, Firearms Background Checks and...; ] NUCLEAR REGULATORY COMMISSION 10 CFR Part 73 RIN 3150-AI49 Enhanced Weapons, Firearms Background Checks, and Security Event Notifications AGENCY: Nuclear Regulatory Commission. ACTION: Supplemental proposed...

  15. 49 CFR 1542.209 - Fingerprint-based criminal history records checks (CHRC).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Fingerprint-based criminal history records checks... Operations § 1542.209 Fingerprint-based criminal history records checks (CHRC). (a) Scope. The following... fingerprint-based CHRC that does not disclose that he or she has a disqualifying criminal offense, as...

  16. 49 CFR 1544.230 - Fingerprint-based criminal history records checks (CHRC): Flightcrew members.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Fingerprint-based criminal history records checks... Fingerprint-based criminal history records checks (CHRC): Flightcrew members. (a) Scope. This section applies... each flightcrew member has undergone a fingerprint-based CHRC that does not disclose that he or she has...

  17. 75 FR 40033 - Proposed Collection; Comment Request for Taxpayer Advocacy Panel (TAP) Tax Check Waiver

    Science.gov (United States)

    2010-07-13

    ... Internal Revenue Service Proposed Collection; Comment Request for Taxpayer Advocacy Panel (TAP) Tax Check...(c)(2)(A)). Currently, the IRS is soliciting comments concerning Taxpayer Advocacy Panel (TAP) Tax...: Taxpayer Advocacy Panel (TAP) Tax Check Waiver. OMB Number: 1545-2092. Abstract: Taxpayer Advocacy Panel...

  18. 12 CFR 210.12 - Return of cash items and handling of returned checks.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Return of cash items and handling of returned... cash items and handling of returned checks. (a) Return of items—(1) Return of cash items handled by... shorter return time. (2) Return of checks not handled by Reserve Banks. A paying bank that receives a...

  19. Gender Check - veel kord soolisusest Ida-Euroopa kunstis / Mare Tralla

    Index Scriptorium Estoniae

    Tralla, Mare, 1967-

    2010-01-01

    Novembris 2010 Viinis toimunud konverentsist, kus analüüsiti näituse "Gender Check. Feminiinsus ja maskuliinsus Ida-Euroopa kunstis" kogemust ning sellele eelnenud ja järgnenud uurimistöö tulemusi. Esitleti artiklite kogumikku "Gender check: a reader : art and theory in Eastern Europe". "Gender Checki" projekti edasisest saatusest ja mõjust

  20. WCET Analysis of ARM Processors using Real-Time Model Checking

    DEFF Research Database (Denmark)

    Toft, Martin; Olesen, Mads Christian; Dalsgaard, Andreas

    2009-01-01

    This paper presents a flexible method that utilises real-time model checking to determine safe and sharp WCETs for processes running on hardware platforms featuring pipelining and caching.......This paper presents a flexible method that utilises real-time model checking to determine safe and sharp WCETs for processes running on hardware platforms featuring pipelining and caching....

  1. Multi-Core Emptiness Checking of Timed Büchi Automata using Inclusion Abstraction

    DEFF Research Database (Denmark)

    Laarman, Alfons; Olesen, Mads Chr.; Dalsgaard, Andreas

    2013-01-01

    This paper contributes to the multi-core model checking of timed automata (TA) with respect to liveness properties, by investigating checking of TA Büchi emptiness under the very coarse inclusion abstraction or zone subsumption, an open problem in this field. We show that in general Büchi emptiness...

  2. The Impact of a Check Dam on Groundwater Recharge and Sedimentation in an Ephemeral Stream

    Directory of Open Access Journals (Sweden)

    Hakan Djuma

    2017-10-01

    Full Text Available Despite the widespread presence of groundwater recharge check dams, there are few studies that quantify their functionality. The objectives of this study are (i to assess groundwater recharge in an ephemeral river with and without a check dam and (ii to assess sediment build-up in the check-dam reservoir. Field campaigns were carried out to measure water flow, water depth, and check-dam topography to establish water volume, evaporation, outflow, and recharge relations, as well as sediment build-up. To quantify the groundwater recharge, a water-balance approach was applied at two locations: at the check dam reservoir area and at an 11 km long natural stretch of the river upstream. Prediction intervals were computed to assess the uncertainties of the results. During the four years of operation, the check dam (storage capacity of 25,000 m3 recharged the aquifer with an average of 3.1 million m3 of the 10.4 million m3 year−1 of streamflow (30%. The lower and upper uncertainty limits of the check dam recharge were 0.1 and 9.6 million m3 year−1, respectively. Recharge from the upstream stretch was 1.5 million m3 year−1. These results indicate that check dams are valuable structures for increasing groundwater resources in semi-arid regions.

  3. 32 CFR Appendix B to Part 86 - Criteria For Criminal History Background Check Disqualification

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Criteria For Criminal History Background Check Disqualification B Appendix B to Part 86 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CRIMINAL HISTORY BACKGROUND CHECKS ON INDIVIDUALS IN CHILD CARE SERVICES Pt...

  4. A characterization of check valve degradation and failure experience in the nuclear power industry

    International Nuclear Information System (INIS)

    Casada, D.A.; Todd, M.D.

    1993-09-01

    Check valve operating problems in recent years have resulted in significant operating transients, increased cost and decreased system availability. As a result, additional attention has beau given to check valves by utilities (resulting in the formation of the Nuclear Industry Check Valve Group), as well as the US Nuclear Regulatory Commission and the American Society of Mechanical Engineers Operation and Maintenance Committee. All these organizations have the fundamental goal of ensuring reliable operation of check valves. A key ingredient to an engineering-oriented reliability improvement effort is a thorough understanding of relevant historical experience. A detailed review of historical failure data, available through the Institute of Nuclear Power Operation's Nuclear Plant Reliability Data System, has been conducted. The focus of the review is on check valve failures that have involved significant degradation of the valve internal parts. A variety of parameters are considered, including size, age, system of service, method of failure discovery, the affected valve parts, attributed causes, and corrective actions

  5. The value of including spirometry in health checks - a randomized controlled study in primary health care

    DEFF Research Database (Denmark)

    Ørts, Lene Maria; Ottesen, Anders Løkke; Bjerregaard, Anne-Louise

    Background Lung diseases are among the most frequent and most serious ailments in Denmark. Preventive health checks including spirometry can be used to detect lung diseases earlier. Over time the attendance at preventive health checks has decreased and at present the response rate is approximately...... 50%. Little is known about initiatives that can influence the attendance rate. Objectives To examine whether focused information on spirometry in the invitation material will influence the attendance in preventive health checks. Materiel/Methods Design: A randomized controlled study on information...... on spirometry embedded in “Check your health Prevention Program, CHPP” from 2015-16. CHPP is a house-hold cluster randomized controlled trial offering a preventive health check to 30-49 year olds in a Danish municipality during the years 2012 through to 2017 (n= 26,216), carried out in collaboration between...

  6. PVeStA: A Parallel Statistical Model Checking and Quantitative Analysis Tool

    KAUST Repository

    AlTurki, Musab

    2011-01-01

    Statistical model checking is an attractive formal analysis method for probabilistic systems such as, for example, cyber-physical systems which are often probabilistic in nature. This paper is about drastically increasing the scalability of statistical model checking, and making such scalability of analysis available to tools like Maude, where probabilistic systems can be specified at a high level as probabilistic rewrite theories. It presents PVeStA, an extension and parallelization of the VeStA statistical model checking tool [10]. PVeStA supports statistical model checking of probabilistic real-time systems specified as either: (i) discrete or continuous Markov Chains; or (ii) probabilistic rewrite theories in Maude. Furthermore, the properties that it can model check can be expressed in either: (i) PCTL/CSL, or (ii) the QuaTEx quantitative temporal logic. As our experiments show, the performance gains obtained from parallelization can be very high. © 2011 Springer-Verlag.

  7. Solid phase double-antibody radioimmunoassay procedure

    International Nuclear Information System (INIS)

    Niswender, G.D.

    1977-01-01

    The present invention is concerned with the radioimmunoassay (RIA) procedure for assaying body fluid content of an antigenic substance which may either be an antigen itself or a hapten capable of being converted, such as by means of reaction with a protein, to an antigenic material. The present invention is concerned with a novel and improved modification of a double-antibody RIA technique in which there is a first antibody that is specific to the antigenic substance suspected to be present in a body fluid from which the assay is intended. The second antibody, however, is not specific to the antigenic substance or analyte, but is an antibody against the first antibody

  8. Production of Monoclonal Antibody against Human Nestin

    OpenAIRE

    Hadavi, Reza; Zarnani, Amir Hassan; Ahmadvand, Negah; Mahmoudi, Ahmad Reza; Bayat, Ali Ahmad; Mahmoudian, Jafar; Sadeghi, Mohammad-Reza; Soltanghoraee, Haleh; Akhondi, Mohammad Mehdi; Tarahomi, Majid; Jeddi-Tehrani, Mahmood; Rabbani, Hodjattallah

    2010-01-01

    We have employed a peptide-based antibody generation protocol for producing antibody against human nestin. Using a 12-mer synthetic peptide from repetitive region of human nestin protein devoid of any N- or O-glyco-sylation sequences, we generated a mouse monoclonal antibody capable of recognizing human, mouse, bovine, and rat nestin. A wide variety of nestin proteins ranging from 140?250 kDa was detected by this antibody. This antibody is highly specific and functional in applications such a...

  9. Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy.

    Science.gov (United States)

    Goldenberg, David M; Sharkey, Robert M; Paganelli, Giovanni; Barbet, Jacques; Chatal, Jean-François

    2006-02-10

    This article reviews the methods of pretargeting, which involve separating the targeting antibody from the subsequent delivery of an imaging or therapeutic agent that binds to the tumor-localized antibody. This provides enhanced tumor:background ratios and the delivery of a higher therapeutic dose than when antibodies are directly conjugated with radionuclides, as currently practiced in cancer radioimmunotherapy. We describe initial promising clinical results using streptavidin-antibody constructs with biotin-radionuclide conjugates in the treatment of patients with malignant gliomas, and of bispecific antibodies with hapten-radionuclides in the therapy of tumors expressing carcinoembryonic antigen, such as medullary thyroid and small-cell lung cancers.

  10. Serum Antibody Biomarkers for ASD

    Science.gov (United States)

    2015-10-01

    45-56. Singh VK. (2009) Phenotypic expression of autoimmune autistic disorder (AAD): A major subset of autism. Ann Clin Psychiat. 21:148-160. 5...spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in communication (verbal and nonverbal), social interactions, and... autoimmunity ; in particular, the generation of antibodies reactive against brain and CNS proteins. The goal of this grant is to identify serum

  11. Antibody Repertoire Development in Swine

    Czech Academy of Sciences Publication Activity Database

    Butler, J. E.; Wertz, N.; Šinkora, Marek

    2017-01-01

    Roč. 5, FEB 17 (2017), s. 255-279 ISSN 2165-8102 R&D Projects: GA ČR GA15-02274S; GA ČR(CZ) GA16-09296S Institutional support: RVO:61388971 Keywords : swine * pre-immune antibody repertoire * ileal Peyer's patches Subject RIV: EE - Microbiology, Virology OBOR OECD: Microbiology Impact factor: 4.708, year: 2016

  12. Toward improved design of check dam systems: A case study in the Loess Plateau, China

    Science.gov (United States)

    Pal, Debasish; Galelli, Stefano; Tang, Honglei; Ran, Qihua

    2018-04-01

    Check dams are one of the most common strategies for controlling sediment transport in erosion prone areas, along with soil and water conservation measures. However, existing mathematical models that simulate sediment production and delivery are often unable to simulate how the storage capacity of check dams varies with time. To explicitly account for this process-and to support the design of check dam systems-we developed a modelling framework consisting of two components, namely (1) the spatially distributed Soil Erosion and Sediment Delivery Model (WaTEM/SEDEM), and (2) a network-based model of check dam storage dynamics. The two models are run sequentially, with the second model receiving the initial sediment input to check dams from WaTEM/SEDEM. The framework is first applied to Shejiagou catchment, a 4.26 km2 area located in the Loess Plateau, China, where we study the effect of the existing check dam system on sediment dynamics. Results show that the deployment of check dams altered significantly the sediment delivery ratio of the catchment. Furthermore, the network-based model reveals a large variability in the life expectancy of check dams and abrupt changes in their filling rates. The application of the framework to six alternative check dam deployment scenarios is then used to illustrate its usefulness for planning purposes, and to derive some insights on the effect of key decision variables, such as the number, size, and site location of check dams. Simulation results suggest that better performance-in terms of life expectancy and sediment delivery ratio-could have been achieved with an alternative deployment strategy.

  13. Application of risk-based methods to inservice testing of check valves

    Energy Technology Data Exchange (ETDEWEB)

    Closky, N.B.; Balkey, K.R.; McAllister, W.J. [and others

    1996-12-01

    Research efforts have been underway in the American Society of Mechanical Engineers (ASME) and industry to define appropriate methods for the application of risk-based technology in the development of inservice testing (IST) programs for pumps and valves in nuclear steam supply systems. This paper discusses a pilot application of these methods to the inservice testing of check valves in the emergency core cooling system of Georgia Power`s Vogtle nuclear power station. The results of the probabilistic safety assessment (PSA) are used to divide the check valves into risk-significant and less-risk-significant groups. This information is reviewed by a plant expert panel along with the consideration of appropriate deterministic insights to finally categorize the check valves into more safety-significant and less safety-significant component groups. All of the more safety-significant check valves are further evaluated in detail using a failure modes and causes analysis (FMCA) to assist in defining effective IST strategies. A template has been designed to evaluate how effective current and emerging tests for check valves are in detecting failures or in finding significant conditions that are precursors to failure for the likely failure causes. This information is then used to design and evaluate appropriate IST strategies that consider both the test method and frequency. A few of the less safety-significant check valves are also evaluated using this process since differences exist in check valve design, function, and operating conditions. Appropriate test strategies are selected for each check valve that has been evaluated based on safety and cost considerations. Test strategies are inferred from this information for the other check valves based on similar check valve conditions. Sensitivity studies are performed using the PSA model to arrive at an overall IST program that maintains or enhances safety at the lowest achievable cost.

  14. The importance of drug checking outside the context of nightlife in Slovenia.

    Science.gov (United States)

    Sande, Matej; Šabić, Simona

    2018-01-12

    The main purpose of the research was to evaluate the implementation of the drug checking service in Slovenia and to obtain the opinion of users included in harm reduction programmes for high-risk drug users and of drug users in nightlife settings on drug checking, the reasons for drug checking, and their attitude towards adulterants in the drugs that they use. The two final unrepresentative research samples included 102 respondents from harm reduction programmes and 554 respondents from the online sample. The questionnaire was designed based on analysis of the interviews conducted with professionals from the programmes, who took part in the drug checking project, and based on previous research on drug use in nightlife. The main findings related to users' opinions on the drug checking service are that users from both samples perceive drug checking as a contribution to risk reduction and that they find providing information for them about the harmful adulterants and substances that they use very important. In addition, users from both samples considered accessibility of the drug checking service as very important and would be in favour of brief counselling at the collection of the drug sample. One of the salient differences between samples was that nightlife drug users found it more important to recognise substances in the drugs that they use. Drug users from two different samples attach a relatively high importance to the drug checking service, and they consider it to be a contribution to risk reduction. As well as drug users in nightlife settings, high-risk drug users also perceive the drug checking service to be important, which is relevant in the phase of planning drug checking services outside the context of nightlife and for the act of incorporating these services into contemporary harm reduction policy.

  15. Assessment of check-dam groundwater recharge with water-balance calculations

    Science.gov (United States)

    Djuma, Hakan; Bruggeman, Adriana; Camera, Corrado; Eliades, Marinos

    2017-04-01

    Studies on the enhancement of groundwater recharge by check-dams in arid and semi-arid environments mainly focus on deriving water infiltration rates from the check-dam ponding areas. This is usually achieved by applying simple water balance models, more advanced models (e.g., two dimensional groundwater models) and field tests (e.g., infiltrometer test or soil pit tests). Recharge behind the check-dam can be affected by the built-up of sediment as a result of erosion in the upstream watershed area. This natural process can increase the uncertainty in the estimates of the recharged water volume, especially for water balance calculations. Few water balance field studies of individual check-dams have been presented in the literature and none of them presented associated uncertainties of their estimates. The objectives of this study are i) to assess the effect of a check-dam on groundwater recharge from an ephemeral river; and ii) to assess annual sedimentation at the check-dam during a 4-year period. The study was conducted on a check-dam in the semi-arid island of Cyprus. Field campaigns were carried out to measure water flow, water depth and check-dam topography in order to establish check-dam water height, volume, evaporation, outflow and recharge relations. Topographic surveys were repeated at the end of consecutive hydrological years to estimate the sediment built up in the reservoir area of the check dam. Also, sediment samples were collected from the check-dam reservoir area for bulk-density analyses. To quantify the groundwater recharge, a water balance model was applied at two locations: at the check-dam and corresponding reservoir area, and at a 4-km stretch of the river bed without check-dam. Results showed that a check-dam with a storage capacity of 25,000 m3 was able to recharge to the aquifer, in four years, a total of 12 million m3 out of the 42 million m3 of measured (or modelled) streamflow. Recharge from the analyzed 4-km long river section without

  16. [Expression of recombinant rubella virus E1 protein and initial application for detecting of antibody].

    Science.gov (United States)

    Yi, Yao; Guo, Min-zhuo; Yu, Tao; Xu, Wen-bo; Yang, Jin-ye; Chen, Si-yong

    2008-10-01

    To apply recombinant rubella virus envelope protein-1 (E1) to detect human rubella virus IgG antibody. Rubella virus E1 protein was expressed in E. coli, purified E1 protein was used as the antigen for the detecting of anti rubella in human sera in the way of enzyme linked Immunosorbant assay (ELISA). The antigenicity of the recombinant protein was checked by WHO rubella sera panel. We detected 200 sera samples, which came from Guangxi Guilin. 93% of these samples were positive. The antigenicity of recombinant E1 is a satisfied candidate antigen for the detecting of human rubella virus antibody. The prevalence of anti rubella virus IgG in Guangxi is 93%. It is at the some level compared with other provinces in China.

  17. Donor-derived HLA antibody production in patients undergoing SCT from HLA antibody-positive donors.

    Science.gov (United States)

    Taniguchi, K; Yoshihara, S; Maruya, E; Ikegame, K; Kaida, K; Hayashi, K; Kato, R; Inoue, T; Fujioka, T; Tamaki, H; Okada, M; Onuma, T; Fujii, N; Kusunoki, Y; Soma, T; Saji, H; Ogawa, H

    2012-10-01

    Pre-existing donor-specific HLA antibodies in patients undergoing HLA-mismatched SCT have increasingly been recognized as a risk factor for primary graft failure. However, the clinical implications of the presence of HLA antibodies in donors remain unknown. We prospectively examined 123 related donors for the presence of HLA antibodies by using a Luminex-based single antigen assay. Of these, 1/57 (1.8%) male, 6/27 (22%) parous female and 0/39 (0%) nonparous female donors were HLA antibody-positive. Then, we determined the presence of HLA antibodies in seven patients who received SCT from antibody-positive donors. Of these, four became HLA antibody-positive after SCT. The specificities of the antibodies that emerged in the patients closely resembled those of the antibodies found in the donors, indicating their production by donor-derived plasma cells. Moreover, the kinetics of the HLA antibody levels were similar in all four patients: levels started increasing within 1 week after SCT and peaked at days 10-21, followed by a gradual decrease. These results suggest that donor-derived HLA antibody production frequently occurs in patients undergoing SCT from antibody-positive donors. Further studies are warranted for clarifying the clinical significance of donor-derived HLA antibodies, including the role of these antibodies in post transplant platelet transfusion refractoriness.

  18. Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex.

    Science.gov (United States)

    Dvorkin, Anna; Silva, Charmaine; McMurran, Thomas; Bisnaire, Liane; Foster, Jane; Szechtman, Henry

    2010-11-01

    The quinpirole sensitization model of obsessive-compulsive disorder was used to investigate the functional role that brain regions implicated in a neuroanatomical circuit of obsessive-compulsive disorder may play in compulsive checking behavior. Following repeated injections of saline or quinpirole (0.5mg/kg, twice per week, ×8 injections) to induce compulsive checking, rats received N-methyl-d-aspartate lesions of the nucleus accumbens core (NAc), orbital frontal cortex (OFC) and basolateral amygdala, or sham lesions. When retested at 17days post-surgery, the results showed effects of NAc and OFC but not basolateral amygdala lesion. NAc lesions affected measures indicative of the amount of checking behavior, whereas OFC lesions affected indices of staying away from checking. The pattern of results suggested that the functional roles of the NAc and OFC in checking behavior are to control the vigor of motor performance and focus on goal-directed activity, respectively. Furthermore, similarities in behavior between quinpirole sham rats and saline NAc lesion rats suggested that quinpirole may drive the vigor of checking by inhibition of NAc neurons, and that the NAc may be a site for the negative feedback control of checking. © 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

  19. Evidence for the safety assurance of the radiation associated equipments for stat-up check

    International Nuclear Information System (INIS)

    Takahashi, Yasuyuki; Igarashi, Hiroshi; Saito, Kyoko; Kawaharada, Yasuhiro; Hirano, Kunihiro; Murase, Kenya; Mochizuki, Teruhito

    2008-01-01

    Based on the new amendment of the Medical Service Law and the Pharmaceutical Affairs Law, the safety control for the medical equipments and devices was strengthened; and a radiological technologist should be stipulated as a safety control manager for the medical equipments and devices. Although it is thought that Start-up check is important for the safety assurance, the enforcement situation is not clear until now. In this report, on the occasion of the start-up of the new Law, questionnaire about the start up check (time and a check items) were investigated from 56 hospitals applying the visit interview. Modality by modality check up time was obtained from 261 institutions by the descriptive study paper type. Start-up check and arming up were applied for almost all modalities about 30 minutes before start of the clinical tests. The check up items for the medical equipments and devices depended on each hospital. Therefore, safety assurance should be established, cooperating with the medical equipment distributors, the hospital sharing the checked results for the patients' safety. (author)

  20. Transient analysis for a system with a tilted disc check valve

    International Nuclear Information System (INIS)

    Jeung, Jaesik; Lee, Kyukwang; Cho, Daegwan

    2014-01-01

    Check valves are used to prevent reverse flow conditions in a variety of systems in nuclear power plants. When a check valve is closed by a reverse flow, the transient load can jeopardize the structural integrity on the piping system and its supports. It may also damage intended function of the in-line components even though the severity of the load differs and depends strongly on types of the check valves. To incorporate the transient load in the piping system, it is very important to properly predict the system response to transients such as a check valve closure accompanied by pump trip and to evaluate the system transient. The one-dimensional transient simulation codes such as the RELAP5/MOD3.3 and TRACE were used. There has not been a single model that integrates the two codes to handle the behavior of a tilted disc check valve, which is designed to mitigate check valve slams by shorting the travel of the disc. In this paper a model is presented to predict the dynamic motion of a tilted disc check valve in the transient simulation using the RELAP5/MOD3.3 code and the model is incorporated in a system transient analysis using control variables of the code. In addition, transient analysis for Essential Service Water (ESW) system is performed using the proposed model and the associated load is evaluated for the system. (author)