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Sample records for bk020014 pall bds

  1. A Museum for Palle Nielsen

    DEFF Research Database (Denmark)

    Thorborg, Christoffer

    2016-01-01

    The present project attempts to articulate architecturally the psychic content in the danish graphic artist and draftsman Palle Nielsen's oeuvre. The museum inscribes itself within the city of Copenhagen as a part of it, but simultaneously establishes a taut vacuum between the city's buildings......, thereby setting these existing, surrounding monumental buildings in relief. The interior of the museum manifests itself as a dramatic, labyrinthine course of empty spaces, within which the visitor is deprived of contact with the city, and potentially loses his or her sense of place....

  2. Precise Positioning of BDS, BDS/GPS: Implications for Tsunami Early Warning in South China Sea

    Directory of Open Access Journals (Sweden)

    Kejie Chen

    2015-11-01

    Full Text Available Global Positioning System (GPS has been proved to be a powerful tool for measuring co-seismic ground displacements with an application to seismic source inversion. Whereas most of the tsunamis are triggered by large earthquakes, GPS can contribute to the tsunami early warning system (TEWS by helping to obtain tsunami source parameters in near real-time. Toward the end of 2012, the second phase of the BeiDou Navigation Satellite System (BDS constellation was accomplished, and BDS has been providing regional positioning service since then. Numerical results indicate that precision of BDS nowadays is equivalent to that of the GPS. Compared with a single Global Satellite Navigation System (GNSS, combined BDS/GPS real-time processing can improve accuracy and especially reliability of retrieved co-seismic displacements. In the present study, we investigate the potential of BDS to serve for the early warning system of tsunamis in the South China Sea region. To facilitate early warnings of tsunamis and forecasting capabilities in this region, we propose to distribute an array of BDS-stations along the Luzon Island (Philippines. By simulating an earthquake with Mw = 8 at the Manila trench as an example, we demonstrate that such an array will be able to detect earthquake parameters in real time with a high degree of accuracy and, hence, contribute to the fast and reliable tsunami early warning system in this region.

  3. Modeling Business Development Services (BDS) in the Tanzania ...

    African Journals Online (AJOL)

    These include services that will guide them to innovations, customer satisfaction, business strategies and awareness. The second objective is to examine the extent to which BDS supply-side factors influence the successful provision of BDS. Here, the study hypothesized that factors on the supply-side (i.e., creativity and ...

  4. Evaluation of GPS/BDS indoor positioning performance and enhancement

    DEFF Research Database (Denmark)

    He, Zhe; Petovello, Mark; Pei, Ling

    2017-01-01

    This paper assesses the potential of using BDS and GPS signals to position in challenged environments such as indoors. Traditional assisted GNSS approaches that use code phase as measurements (i.e., coarse-time solutions) are shown to be prone to multipath and noise. An enhanced approach that has...... superior sensitivity and positioning performance—the so-called direct positioning receiver architecture—has been implemented and evaluated using live indoor BDS and/or GPS signals. Real indoor experiments have been conducted in Shanghai and significant improvement has been observed with enhanced approaches......: results with BDS constellation show better horizontal positioning performance (biases are less than 10m) than using GPS alone, but are slightly worse in the vertical axis; when using the enhanced approach with BDS and GPS, both horizontal and vertical axes show promising results for the environments...

  5. Antihyperlipidemic Activities of Common Garden Peony ( Paeonia lactifl ora Pall.

    Directory of Open Access Journals (Sweden)

    Tserenlkham Tserendejid

    2013-12-01

    Full Text Available We studied different extracts of aboveground and underground parts of Paeonia lactifl ora Pall.in experiment. For doing so this research needs to start up with total cholesterol. Total cholesterol is a direct cholesterol measurement that measures all cholesterol molecules in the blood, including low density lipoproteins (LDL, high density lipoproteins (HDL, and very low density lipoproteins (VLDL. The serum total cholesterol (TC and low density lipoproteins (LDL levels were signifi cantly different in the experimentally-induced hypercholesterolemia rats. Effect on serum triglyceride (TG level compared to control group, simvastatin and hypercholesterolemia diet (HD, but almost all were similar with simvastatin. Effect on serum high density lipoproteins (HDL level compared between those. Extracts (PL1, PL2 were lower, almost the same with hypercholesterolemia diet (HD.

  6. Päike ja pall : [luuletused] / Ott Arder

    Index Scriptorium Estoniae

    Arder, Ott

    2001-01-01

    Sisu: Päike ja pall ; Õuna ja lõuna ; Kõige ilusam asi ; Emajõgi ; Väikemehe probleem ; Küünal ; Kapten ; Kaksteist kilu ja kaks teist kilu ; Suur ja seisev, ripub seinal ; Laul tagumisest vagunist ; Ultimaatum ; Ilus algus ; Pliiat(siga) ; Mure ja Amour ; kodust ja loomadest ; Eesli jõulupuu ; Aja saapad ; Lendav järv ; Unenäolaul ; Tere hommikust ja õhtust ; Kõik, mis juhtub ja ei juhtu ; Kas panna päkka või visata varvast ; Lihtne mees ; Väljaütlev ; Külm sõda ; Ohkav kruvi ; Metsa all ; Lauluke ; Unemetsades ; Suur rõõm ja väike mure ; Hea muusika ; Koer poiss ja plika ; Kes mängida veel ei oska ; Raske lumi ; Mere kaldal ; Unenäoukse taga

  7. Improving Ambiguity Resolution for Medium Baselines Using Combined GPS and BDS Dual/Triple-Frequency Observations.

    Science.gov (United States)

    Gao, Wang; Gao, Chengfa; Pan, Shuguo; Wang, Denghui; Deng, Jiadong

    2015-10-30

    The regional constellation of the BeiDou navigation satellite system (BDS) has been providing continuous positioning, navigation and timing services since 27 December 2012, covering China and the surrounding area. Real-time kinematic (RTK) positioning with combined BDS and GPS observations is feasible. Besides, all satellites of BDS can transmit triple-frequency signals. Using the advantages of multi-pseudorange and carrier observations from multi-systems and multi-frequencies is expected to be of much benefit for ambiguity resolution (AR). We propose an integrated AR strategy for medium baselines by using the combined GPS and BDS dual/triple-frequency observations. In the method, firstly the extra-wide-lane (EWL) ambiguities of triple-frequency system, i.e., BDS, are determined first. Then the dual-frequency WL ambiguities of BDS and GPS were resolved with the geometry-based model by using the BDS ambiguity-fixed EWL observations. After that, basic (i.e., L1/L2 or B1/B2) ambiguities of BDS and GPS are estimated together with the so-called ionosphere-constrained model, where the ambiguity-fixed WL observations are added to enhance the model strength. During both of the WL and basic AR, a partial ambiguity fixing (PAF) strategy is adopted to weaken the negative influence of new-rising or low-elevation satellites. Experiments were conducted and presented, in which the GPS/BDS dual/triple-frequency data were collected in Nanjing and Zhengzhou of China, with the baseline distance varying from about 28.6 to 51.9 km. The results indicate that, compared to the single triple-frequency BDS system, the combined system can significantly enhance the AR model strength, and thus improve AR performance for medium baselines with a 75.7% reduction of initialization time on average. Besides, more accurate and stable positioning results can also be derived by using the combined GPS/BDS system.

  8. Preface: BeiDou Navigation Satellite System (BDS)/GNSS+: Recent progress and new applications

    Science.gov (United States)

    Jin, Shuanggen

    2017-02-01

    Nowadays, the new China's BeiDou Navigation Satellite System (BDS) has been developed well. At the end of 2016, over 23 BDS satellites were launched, including five geostationary Earth orbit (GEO) satellites, five inclined geosynchronous orbit (IGSO) satellites and nine medium Earth orbit (MEO) satellites. The current BDS service covers China and most Asia-Pacific regions with accuracy of better than 10 m in positioning, 0.2 m/s in velocity and 50 ns in timing. The BDS with global coverage will be completely established by 2020 with five GEO satellites and 30 MEO satellites. The main function of BDS is the positioning, navigation and timing (PNT) as well as short message communications. Together with the United States' GPS, Russia's GLONASS and the European Union's Galileo system as well as other regional augmentation systems, more new applications of multi-Global Navigation Satellite Systems (GNSS) will be exploited and realized in the next decades.

  9. Anti-depressant effect of Paeonia lactiflora Pall extract in rats | Yu ...

    African Journals Online (AJOL)

    Neither PLPE nor fluoxetine, at the doses tested, produced significant effects on locomotor activity. Conclusion: The results suggest that Paeonia lactiflora Pall is a potential agent for the treatment of depression in humans. Keywords: Paeonia lactiflora, Depression, Tail suspension test, Forced swimming test ...

  10. The eukaryotic enzyme Bds1 is an alkyl but not an aryl sulfohydrolase.

    Science.gov (United States)

    Waddell, Grace L; Gilmer, Caroline R; Taylor, Nicholas G; Reveral, John Randolf S; Forconi, Marcello; Fox, Jennifer L

    2017-09-16

    The eukaryotic enzyme Bds1 in Saccharomyces cerevisiae is a metallo-β-lactamase-related enzyme evolutionarily originating from bacterial horizontal gene transfer that serves an unknown biological role. Previously, Bds1 was reported to be an alkyl and aryl sulfatase. However, we demonstrate here that Bds1 acts on primary alkyl sulfates (of 6-12 carbon atoms) but not the aryl sulfates p-nitrophenyl sulfate and p-nitrocatechol sulfate. The apparent catalytic rate constant for hydrolysis of the substrate 1-hexyl sulfate by Bds1 is over 100 times lower than that of the reaction catalyzed by its bacterial homolog SdsA1. We show that Bds1 shares a catalytic mechanism with SdsA1 in which the carbon atom of the sulfate ester is the subject of nucleophilic attack, rather than the sulfur atom, resulting in C-O bond lysis. In contrast to SdsA1 and another bacterial homolog with selectivity for secondary alkyl sulfates named Pisa1, Bds1 does not show any substantial activity towards secondary alkyl sulfates. Neither Bds1 nor SdsA1 have any significant activity towards a branched primary alkyl sulfate, primary and secondary steroid sulfates, or phosphate diesters. Therefore, the enzymes homologous to SdsA1 that have been identified and characterized thus far vary in their selectivity towards primary and secondary alkyl sulfates but do not exhibit aryl sulfatase activity. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. ETV REPORT: REMOVAL OF CHEMICAL CONTAMINANTS IN DRINKING WATER — PALL/KINETICO PUREFECTA DRINKING WATER TREATMENT SYSTEM

    Science.gov (United States)

    The Pall/Kinetico Purefecta™ POU drinking water treatment system was tested for removal of aldicarb, benzene, cadmium, carbofuran, cesium, chloroform, dichlorvos, dicrotophos, fenamiphos, mercury, mevinphos, oxamyl, strontium, and strychnine. The Purefecta™ employs several compon...

  12. De Novo Transcriptome Characterization, Gene Expression Profiling and Ionic Responses of Nitraria sibirica Pall. under Salt Stress

    Directory of Open Access Journals (Sweden)

    Huanyong Li

    2017-06-01

    Full Text Available Nitraria sibirica Pall., a typical halophyte of great ecological value, is widely distributed in desert, saline, and coastal saline-alkali environments. Consequently, researching the salt tolerance mechanism of N. sibirica Pall. has great significance to the cultivation and utilization of salt-tolerant plants. In this research, RNA-seq, digital gene expression (DGE, and high flux element analysis technologies were used to investigate the molecular and physiological mechanisms related to salt tolerance of N. sibirica Pall. Integrative analysis and de novo transcriptome assembly generated 137,421 unigenes. In total, 58,340 and 34,033 unigenes were annotated with gene ontology (GO terms and mapped in Kyoto Encyclopedia of Genes and Genomes (KEGG pathways, respectively. Three differentially expressed genes (DEGs libraries were subsequently constructed from the leaves of N. sibirica Pall. seedlings under different treatments: control (CK, light short-term salt stress (CL2, and heavy long-term salt stress (CL6. Eight hundred and twenty-six, and 224 differentially expressed genes were identified in CL2 and CL6 compared to CK, respectively. Finally, ionomic analysis of N. sibirica Pall. seedlings treated with 0, 100, 200 or 300 mM concentrations of NaCl for one day showed that the uptake and distribution of Ca, Cu, Fe, Mg and K in different organs of N. sibirica Pall. were significantly affected by salt stress. Our findings have identified potential genes involved in salt tolerance and in the reference transcriptome and have revealed the salt tolerance mechanism in N. sibirica Pall. These findings will provide further insight into the molecular and physiological mechanisms related to salt stress in N. sibirica Pall. and in other halophytes.

  13. Effect of the Improved Pall Friction Damper on the Seismic Response of Steel Frames

    Directory of Open Access Journals (Sweden)

    P. H. Sarjou,

    2017-08-01

    Full Text Available Energy-absorbing dampers are used to reinforce structures which are vulnerable to earthquakes. This study evaluates the performance of Improved Pall Frictional Dampers (IPFD which is a type of Pall Frictional Damper (PFD. For this purpose, this study compares the performances of steel frames with concentric steel bracing reinforced by IPFD and steel frames with concentric steel bracing with no damper. Frames with different stories and pans were modelled in sap2000 and exposed to accelerograms of earthquakes for non-linear time history analysis. Results of analysis were studied; parameters such as story displacement, base shear and absorbed energy were compared in steel frames with damper and without damper.

  14. Improving Ambiguity Resolution for Medium Baselines Using Combined GPS and BDS Dual/Triple-Frequency Observations

    Directory of Open Access Journals (Sweden)

    Wang Gao

    2015-10-01

    Full Text Available The regional constellation of the BeiDou navigation satellite system (BDS has been providing continuous positioning, navigation and timing services since 27 December 2012, covering China and the surrounding area. Real-time kinematic (RTK positioning with combined BDS and GPS observations is feasible. Besides, all satellites of BDS can transmit triple-frequency signals. Using the advantages of multi-pseudorange and carrier observations from multi-systems and multi-frequencies is expected to be of much benefit for ambiguity resolution (AR. We propose an integrated AR strategy for medium baselines by using the combined GPS and BDS dual/triple-frequency observations. In the method, firstly the extra-wide-lane (EWL ambiguities of triple-frequency system, i.e., BDS, are determined first. Then the dual-frequency WL ambiguities of BDS and GPS were resolved with the geometry-based model by using the BDS ambiguity-fixed EWL observations. After that, basic (i.e., L1/L2 or B1/B2 ambiguities of BDS and GPS are estimated together with the so-called ionosphere-constrained model, where the ambiguity-fixed WL observations are added to enhance the model strength. During both of the WL and basic AR, a partial ambiguity fixing (PAF strategy is adopted to weaken the negative influence of new-rising or low-elevation satellites. Experiments were conducted and presented, in which the GPS/BDS dual/triple-frequency data were collected in Nanjing and Zhengzhou of China, with the baseline distance varying from about 28.6 to 51.9 km. The results indicate that, compared to the single triple-frequency BDS system, the combined system can significantly enhance the AR model strength, and thus improve AR performance for medium baselines with a 75.7% reduction of initialization time on average. Besides, more accurate and stable positioning results can also be derived by using the combined GPS/BDS system.

  15. Positioning Accuracy Analysis of GPS/BDS/GLONASS Network RTK Based on DREAMNET

    Directory of Open Access Journals (Sweden)

    YAO Yibin

    2016-09-01

    Full Text Available With BDS being continually providing service in the Asia-Pacific Region, GLONASS being fully operational with 24 satellites in orbit again and GPS modernization, multi-GNSS network RTK will become the development trend of network RTK in the future. The data of multi-GNSS will be process by data reserving, editing and managing system of network RTK (DREAMNET, which developed independently by this research group, to analyze and compare the positioning accuracy between different combinations of global navigation satellite system. According to the experiment, the positioning accuracy of GPS/BDS/GLONASS network RTK and GPS/BDS network RTK is highest, GPS and BDS only second. Besides, with the increasing of the cut-off elevation, the availability of single GPS network RTK significantly reduces. However with 40°cut-off elevations, positioning service with the accuracy of 0.005m in horizontal, 0.025m in vertical will be provided by GPS/BDS/GLONASS network RTK in 99.84% time of a day. Finally, the statistics of positioning accuracy for 15days show that the accuracy of 0.01m in horizontal, 0.025m in vertical could be reached in six situations, which including BDS and BDS/GLONASS network RTK. Besides, the accuracy of 0.006m in horizontal, 0.015m in vertical could be reached by GPS/BDS/GLONASS network RTK, proving that the positioning accuracy and stability of DREAMNET can meet the needs of surveying and mapping.

  16. The hair of the common hare (Lepus europaeus Pall.) and of the common vole (Microtus arvalis Pall.) as indicator of the environmental pollution

    International Nuclear Information System (INIS)

    Paukert, J.

    1986-01-01

    Hairs of common hare (Lepus europaeus Pall.) and of common vole (Microtus arvalis Pall.) living in immission zones were investigated by INAA. Both the hare and the vole are almost exclusively herbivores; they consume relatively large amounts of contaminated food and reflect reliably the contamination degree of the respective ecosystem. The use of free-living animals for assessing environmental quality may complete effectively the information obtained by the examination of population. Though free-living animals lead a rather different way of existence it has been found that analyses of their hairs correlate very well with analyses of human hair. It may be expected that the changes in concentrations of heavy metals will manifest themselves earlier in animals than in men because the animals are strictly tied to local food sources. The hair samples of hares contained increased concentrations of Sm, La, Au, As, Se, Cr, Sc, Fe, Ce, Th and Co. The hairs of voles showed increased concentrations of Sm, La, Zn, As, Se, Cr, Sc, Fe, Sb, Ce, Cs and Co. A marked trend towards cumulation in hair was observed for the following elements: As, Se, Sc and Fe. The increase of their concentrations in the hairs of animals from the immission regions amounted to as much as 10 3 %. (author)

  17. High-accuracy Long Arc Almanac Model Design for BDS

    Directory of Open Access Journals (Sweden)

    CHANG Zhiqiao

    2018-03-01

    Full Text Available Almanac parameters can be used to assist signal acquisition for both conventional navigation and autonomous navigation. The extended validity of the almanac parameters not only enables the terrestrial receiver to make full use of almanac data when starting up,but also determines the frequency of the almanac uploaded and the satellite storage resources on-board for autonomous navigation with inter-satellite link observation. Based on analysis of the major perturbations of three types of BeiDou satellites and their effects on the long-term and long-period terms of the orbital elements,an almanac model with six orbital elements and five perturbation parameters is designed. The almanac fitting test is carried out based on the 90-day long arc orbit of BeiDou satellites in orbit throughout 2013. The results show that the new almanac model improves accuracy of almanac fitting. For Geostationary Earth Orbit (GEO and Inclined Geosynchronous Orbit (IGSO satellites,position fitting error is reduced from 200 km to more than 10 km even to several km and velocity error is reduced from 15 m/s to 0.6 m/s. The accuracy of the new model is about 20 to 30 times higher than that of the conventional model. For Medium Earth Orbit (MEO satellite,position fitting error is about 5 km and velocity error is about 0.6 m/s regardless of which model,and the accuracy of the new method is improved about 15%. For 10 km position error upper limit of inter-satellite link,the maximum fitting arc length of the conventional model is about 14 days,and the maximum fitting arc length of the new almanac model can be extended to 45 days. The new almanac model extends the validity of almanac parameters,and optimizes almanac model for BeiDou Navigation Satellite System (BDS.

  18. Estimation of BDS DCB Combining GIM and Different Zero-mean Constraints

    Directory of Open Access Journals (Sweden)

    YAO Yibin

    2017-02-01

    Full Text Available As the limited number of the BeiDou Navigation Satellite System (BDS satellites and tracking stations currently, it's difficult to attain daily DCBs solution with precisely high accuracy based on BeiDou single system. In order to overcome the weakness above, two different zero-mean constraints for BDS satellites, called constraint one and constraint two, respectively, are used to estimate DCBs of BDS based on BeiDou observations from the multi-GNSS experiment (MGEX network and global ionosphere maps (GIM from the Center for Orbit Determination in Europe (CODE. The results show that the systematic difference of the overall trend under two different constraints is consistent, and the systematic difference of DCBC2I-C7I and DCBC2I-C6I is -3.3 ns and 1.2 ns, respectively. The systematic difference between BDS satellite DCBs and receiver DCBs has the same absolute value, but opposite signs instead. Compared to constraint one, The DCBs estimation of IGSO/MEO satellites under constraint two are more stable (the improvement of satellites DCBC2I-C7I and DCBC2I-C6I STD are up to 21%, 13%, respectively, the stability of IGSO and MEO satellites (STDs are within 0.1 ns, 0.2 ns, respectively is better than that of GEO satellites (STDs are 0.15~0.32 ns. DCB estimation of constraint one is not only consistent with the CAS/DLR products (Bias:-0.4~0.2 ns, but also takes into account the stability of BDS satellites DCB. Under the two different constraints, there is no obvious change in BDS receiver DCBs, meaning that the selection of constraints has no obvious influence on the stability of BDS receivers DCBs. The overall stability of BDS receiver DCBs is better than 1 ns. Due to the accuracy discrepancy of GIM in different latitudes, the stability of BDS receiver DCBs in the middle-high latitude (STDs are within 0.4 ns is better than that in low latitude region (STDs are 0.8~1 ns.

  19. The BDS Triple Frequency Pseudo-range Correlated Stochastic Model of Single Station Modeling Method

    Directory of Open Access Journals (Sweden)

    HUANG Lingyong

    2017-05-01

    Full Text Available In order to provide a reliable pseudo-range stochastic model, a method is studied to estimate the BDS triple-frequency pseudo-range related stochastic model based on three BDS triple-frequency pseudo-range minus carrier (GIF combinations using the data of a single station. In this algorithm, the low order polynomial fitting method is used to fit the GIF combination in order to eliminate the error and other constants except non pseudo noise at first. And then, multiple linear regression analysis method is used to model the stochastic function of three linearly independent GIF combinations. Finally the related stochastic model of the original BDS triple-frequency pseudo-range observations is obtained by linear transformation. The BDS triple-frequency data verification results show that this algorithm can get a single station related stochastic model of BDS triple-frequency pseudo-range observation, and it is advantageous to provide accurate stochastic model for navigation and positioning and integrity monitoring.

  20. Characteristics of the BDS Carrier Phase Multipath and Its Mitigation Methods in Relative Positioning.

    Science.gov (United States)

    Dai, Wujiao; Shi, Qiang; Cai, Changsheng

    2017-04-07

    The carrier phase multipath effect is one of the most significant error sources in the precise positioning of BeiDou Navigation Satellite System (BDS). We analyzed the characteristics of BDS multipath, and found the multipath errors of geostationary earth orbit (GEO) satellite signals are systematic, whereas those of inclined geosynchronous orbit (IGSO) or medium earth orbit (MEO) satellites are both systematic and random. The modified multipath mitigation methods, including sidereal filtering algorithm and multipath hemispherical map (MHM) model, were used to improve BDS dynamic deformation monitoring. The results indicate that the sidereal filtering methods can reduce the root mean square (RMS) of positioning errors in the east, north and vertical coordinate directions by 15%, 37%, 25% and 18%, 51%, 27% in the coordinate and observation domains, respectively. By contrast, the MHM method can reduce the RMS by 22%, 52% and 27% on average. In addition, the BDS multipath errors in static baseline solutions are a few centimeters in multipath-rich environments, which is different from that of Global Positioning System (GPS) multipath. Therefore, we add a parameter representing the GEO multipath error in observation equation to the adjustment model to improve the precision of BDS static baseline solutions. And the results show that the modified model can achieve an average precision improvement of 82%, 54% and 68% in the east, north and up coordinate directions, respectively.

  1. Convergence Time and Positioning Accuracy Comparison between BDS and GPS Precise Point Positioning

    Directory of Open Access Journals (Sweden)

    ZHANG Xiaohong

    2015-03-01

    Full Text Available BDS/GPS data from MGEX were processed by TriP 2.0 software developed at Wuhan University. Both static and kinematic float PPP are tested by adopting precise satellite orbits and clocks provided by Research Center of GNSS, Wuhan University. The results show that the convergence time of BDS static PPP is about 80min while kinematic PPP is about 100min. For 3h observations, static positioning accuracy of 5 cm and kinematic positioning accuracy of 8 cm in horizontal, about 12 cm in vertical can be achieved. Similar to GPS PPP, precision in east component is worse than north. At present, BDS PPP needs longer convergence time than GPS PPP to reach an absolute positioning accuracy of cm~dm due to the lack of global tracking stations and the limited accuracy of orbit and clock products.

  2. BDS/GPS Dual Systems Positioning Based on the Modified SR-UKF Algorithm

    Directory of Open Access Journals (Sweden)

    JaeHyok Kong

    2016-05-01

    Full Text Available The Global Navigation Satellite System can provide all-day three-dimensional position and speed information. Currently, only using the single navigation system cannot satisfy the requirements of the system’s reliability and integrity. In order to improve the reliability and stability of the satellite navigation system, the positioning method by BDS and GPS navigation system is presented, the measurement model and the state model are described. Furthermore, the modified square-root Unscented Kalman Filter (SR-UKF algorithm is employed in BDS and GPS conditions, and analysis of single system/multi-system positioning has been carried out, respectively. The experimental results are compared with the traditional estimation results, which show that the proposed method can perform highly-precise positioning. Especially when the number of satellites is not adequate enough, the proposed method combine BDS and GPS systems to achieve a higher positioning precision.

  3. Comparative study of the fenwal and pall microaggregate filters used for the production of leucocyte-poor blood.

    Science.gov (United States)

    Treleaven, J G; Patterson, K G; Blagdon, J

    1982-01-01

    Eighty units of whole blood in its third week of shelf-life were filtered through the Pall of Fenwal microaggregate filter. Half of these units were centrifuged before filtration. White cell removal was approximately 30% for the Fenwal filter both with and without prior centrifugation; for the Pall filter, removal was 7% without centrifugation and 30% with centrifugation. It is suggested that these simple filters are a useful way of reducing both platelet and white cell content of blood administered to patients requiring multiple transfusion. Their use may delay development of white cell and platelet antibodies obviating the use of washed or frozen cells in these patients. Images PMID:7085918

  4. Precise orbit determination of Multi-GNSS constellation including GPS GLONASS BDS and GALIEO

    Science.gov (United States)

    Dai, Xiaolei

    2014-05-01

    In addition to the existing American global positioning system (GPS) and the Russian global navigation satellite system (GLONASS), the new generation of GNSS is emerging and developing, such as the Chinese BeiDou satellite navigation system (BDS) and the European GALILEO system. Multi-constellation is expected to contribute to more accurate and reliable positioning and navigation service. However, the application of multi-constellation challenges the traditional precise orbit determination (POD) strategy that was designed usually for single constellation. In this contribution, we exploit a more rigorous multi-constellation POD strategy for the ongoing IGS multi-GNSS experiment (MGEX) where the common parameters are identical for each system, and the frequency- and system-specified parameters are employed to account for the inter-frequency and inter-system biases. Since the authorized BDS attitude model is not yet released, different BDS attitude model are implemented and their impact on orbit accuracy are studied. The proposed POD strategy was implemented in the PANDA (Position and Navigation Data Analyst) software and can process observations from GPS, GLONASS, BDS and GALILEO together. The strategy is evaluated with the multi-constellation observations from about 90 MGEX stations and BDS observations from the BeiDou experimental tracking network (BETN) of Wuhan University (WHU). Of all the MGEX stations, 28 stations record BDS observation, and about 80 stations record GALILEO observations. All these data were processed together in our software, resulting in the multi-constellation POD solutions. We assessed the orbit accuracy for GPS and GLONASS by comparing our solutions with the IGS final orbit, and for BDS and GALILEO by overlapping our daily orbit solution. The stability of inter-frequency bias of GLONASS and inter-system biases w.r.t. GPS for GLONASS, BDS and GALILEO were investigated. At last, we carried out precise point positioning (PPP) using the multi

  5. Haematological studies on micropopulations of Clethrionomys rutilus Pall under different radioecological conditions

    International Nuclear Information System (INIS)

    Borodkin, P.A.; Testov, B.V.

    1980-01-01

    The effect of low dose ionizing radiation on living organisms is studied. The blood of Clethrionomys rutilus Pall which habitates under various radioecological conditions is studied. It is taken into account that hematologic indices reflex the general state of the organism and prove to be a sensitive test of physiological alterations in the organism. The animals were taken on the territory with the increased amount of uranium and thorium in the underlying original rock. Average radiation doses from external gamma radiation on experimental and control territories constitute 0.86 and 0.1 rem/year, respectively. Radiation from thoron, radon and products of their decay condition the dose of 2 rem/year on the experimental territory and 0.1 rem/year on the control territory. Blood for investigation is taken with the method of decapitation. A 5% level of importance of differences is taken for the statistic processing of results obtained. The investigation has revealed no considerable differences between micropopulations of Clethrionomys rutilus Pall habitating different radioecological conditions over all indices of the red blood studied. As considers the composition of white blood, statistically considerable excess of the general amount of leukocytes in wintered males from the radioactive territory is found. An insignificant excess of this index has been noted in other groups of animals, as well

  6. Comparative study of anxiety index and stress coping skills in first and second year BDS students of Sinhgad Dental College, Pune

    OpenAIRE

    Rajeev Saxena

    2015-01-01

    Objectives To know the Anxiety index and stress coping skills in first and second year BDS students. Methods 188 students received a pre-validated module by Zung anxiety self-assessment tool, and Coping as measured by “Ways of coping scale by Folkman and Lazarus. Results Overall results show higher anxiety levels amongst first BDS students compared to second BDS. Conclusions Stress coping module should be introduced at the earlier stage i.e. First BDS which would help the...

  7. An alternative to the BDS test: integration across the correlation integral

    Czech Academy of Sciences Publication Activity Database

    Kočenda, Evžen

    2001-01-01

    Roč. 20, č. 3 (2001), s. 337-351 ISSN 0747-4938 Institutional research plan: CEZ:AV0Z7085904 Keywords : BDS test Subject RIV: BB - Applied Statistics, Operational Research http://search. ebscohost .com/login.aspx?direct=true&db=bth&AN=8533996&site=ehost-live

  8. An Optimized Method to Detect BDS Satellites' Orbit Maneuvering and Anomalies in Real-Time.

    Science.gov (United States)

    Huang, Guanwen; Qin, Zhiwei; Zhang, Qin; Wang, Le; Yan, Xingyuan; Wang, Xiaolei

    2018-02-28

    The orbital maneuvers of Global Navigation Satellite System (GNSS) Constellations will decrease the performance and accuracy of positioning, navigation, and timing (PNT). Because satellites in the Chinese BeiDou Navigation Satellite System (BDS) are in Geostationary Orbit (GEO) and Inclined Geosynchronous Orbit (IGSO), maneuvers occur more frequently. Also, the precise start moment of the BDS satellites' orbit maneuvering cannot be obtained by common users. This paper presented an improved real-time detecting method for BDS satellites' orbit maneuvering and anomalies with higher timeliness and higher accuracy. The main contributions to this improvement are as follows: (1) instead of the previous two-steps method, a new one-step method with higher accuracy is proposed to determine the start moment and the pseudo random noise code (PRN) of the satellite orbit maneuvering in that time; (2) BDS Medium Earth Orbit (MEO) orbital maneuvers are firstly detected according to the proposed selection strategy for the stations; and (3) the classified non-maneuvering anomalies are detected by a new median robust method using the weak anomaly detection factor and the strong anomaly detection factor. The data from the Multi-GNSS Experiment (MGEX) in 2017 was used for experimental analysis. The experimental results and analysis showed that the start moment of orbital maneuvers and the period of non-maneuver anomalies can be determined more accurately in real-time. When orbital maneuvers and anomalies occur, the proposed method improved the data utilization for 91 and 95 min in 2017.

  9. The BDS iGMAS RIOS station at Observatório Nacional, Rio de Janeiro

    Science.gov (United States)

    Humberto Andrei, Alexandre; Song, Shuli; Junqueira, Selma; Beauvalet, Laurene

    2016-07-01

    GNSS navigation satellites are currently being developed by all major players in the science and technology scene, to compete with the GPS system. Because their applications span many different areas, from traffic and cargo control, to geodesy and seismic monitoring, it is required to assess the coherence between the different constellations. BDS is the GNSS system currently developed in China. Its first generation of satellites consisted of 3 geostationnary satellites allowing geolocalisation in China only. In addition to these satellites, other satellites have been launched in geostationnary and geosynchronous orbits, as well as satellites orbiting with a classical GNSS semi-major axis. With these additions, the BDS system possesses 19 operating satellites, and though the system is mostly efficient for geolocalisation in Asia, the satellites are also visible in other parts of the globe. In parallel to the development of the BDS constellation, China has launched the iGMAS (International GNSS Monitoring and Assessment Service) project to develop a global tracking network of multi-GNSS geodetic receivers. One of the goals of this project is to evaluate the efficiency of the BDS constellation as well as the efficiency of the receivers developed by the Chinese laboratories. As part of the Brazilian program COSBAN leaded by the Foreign Affairs Ministry to foster up the science and technology partnership with China, materialized by the collaboration between the Shanghai Astronomical Observatory/CAS and the Observatório Nacional/MCTI, in Rio de Janeiro. Through it the RIOS-iGMAS station was installed at Observatório Nacional, where the RJEP GNSS station already operates as part of the Brazilian reference system. Thus at the Observatório Nacional can be observed satellites from any constellation with both systems of reception, leading to a direct, efficient way to compare the results obtained for each network. In this communication we focus on the determination of the

  10. Evaluation on real-time dynamic performance of BDS in PPP, RTK, and INS tightly aided modes

    Science.gov (United States)

    Gao, Zhouzheng; Li, Tuan; Zhang, Hongping; Ge, Maorong; Schuh, Harald

    2018-05-01

    Since China's BeiDou satellite navigation system (BDS) began to provide regional navigation service for Asia-Pacific region after 2012, more new generation BDS satellites have been launched to further expand BDS's coverage to be global. In this contribution, precise positioning models based on BDS and the corresponding mathematical algorithms are presented in detail. Then, an evaluation on BDS's real-time dynamic positioning and navigation performance is presented in Precise Point Positioning (PPP), Real-time Kinematic (RTK), Inertial Navigation System (INS) tightly aided PPP and RTK modes by processing a set of land-borne vehicle experiment data. Results indicate that BDS positioning Root Mean Square (RMS) in north, east, and vertical components are 2.0, 2.7, and 7.6 cm in RTK mode and 7.8, 14.7, and 24.8 cm in PPP mode, which are close to GPS positioning accuracy. Meanwhile, with the help of INS, about 38.8%, 67.5%, and 66.5% improvements can be obtained by using PPP/INS tight-integration mode. Such enhancements in RTK/INS tight-integration mode are 14.1%, 34.0%, and 41.9%. Moreover, the accuracy of velocimetry and attitude determination can be improved to be better than 1 cm/s and 0.1°, respectively. Besides, the continuity and reliability of BDS in both PPP and RTK modes can also be ameliorated significantly by INS during satellite signal missing periods.

  11. Biological consequences of increased natural radiation background for Microtus oeconomus Pall. populations

    Energy Technology Data Exchange (ETDEWEB)

    Kudyasheva, Alevtina G. [Radioecology Department, Institute of Biology, Komi Scientific Center, Ural Division RAS, 28 Kommunisticheskaya ul., Syktyvkar 167982, Komi Republic (Russian Federation); Shishkina, Ludmila N. [Emanuel Institute of Biochemical Physics RAS, Kosygina 4, Moscow 119991 (Russian Federation); Shevchenko, Oksana G. [Radioecology Department, Institute of Biology, Komi Scientific Center, Ural Division RAS, 28 Kommunisticheskaya ul., Syktyvkar 167982, Komi Republic (Russian Federation)], E-mail: shevchenko@ib.komisc.ru; Bashlykova, Ludmila A.; Zagorskaya, Nadezhda G. [Radioecology Department, Institute of Biology, Komi Scientific Center, Ural Division RAS, 28 Kommunisticheskaya ul., Syktyvkar 167982, Komi Republic (Russian Federation)

    2007-09-15

    The results of long-term investigations (1981-1999) on the state of Microtus oeconomus Pall. (tundra vole) population, living under the increased natural radiation background for a long time (for more than 100 generations), are presented. Population density dynamics, morphophysiological parameters, state of the lipid peroxidation regulatory system in different tissues and the cytogenetic effects in bone marrow cells of animals have been analyzed. It is shown that tundra voles from the studied radioactively contaminated areas differ from those on natural radiation background area for the parameters measured. The results of this long-term investigation show that qualitatively new sub-populations of tundra vole on these areas have evolved, which are able to survive in radioactively contaminated environment.

  12. Biological consequences of increased natural radiation background for Microtus oeconomus Pall. populations

    International Nuclear Information System (INIS)

    Kudyasheva, Alevtina G.; Shishkina, Ludmila N.; Shevchenko, Oksana G.; Bashlykova, Ludmila A.; Zagorskaya, Nadezhda G.

    2007-01-01

    The results of long-term investigations (1981-1999) on the state of Microtus oeconomus Pall. (tundra vole) population, living under the increased natural radiation background for a long time (for more than 100 generations), are presented. Population density dynamics, morphophysiological parameters, state of the lipid peroxidation regulatory system in different tissues and the cytogenetic effects in bone marrow cells of animals have been analyzed. It is shown that tundra voles from the studied radioactively contaminated areas differ from those on natural radiation background area for the parameters measured. The results of this long-term investigation show that qualitatively new sub-populations of tundra vole on these areas have evolved, which are able to survive in radioactively contaminated environment

  13. Impact of the Initial State on BDS Real-Time Orbit Determination Filter Convergence

    Directory of Open Access Journals (Sweden)

    Yun Qing

    2018-01-01

    Full Text Available High precision real-time orbit of navigation satellites are usually predicted based on batch estimation solutions, which is highly dependent on the accuracy of the dynamic model. However, for the BDS satellites, the accuracy and reliability of the predicted orbit usually decrease due to the inaccurate dynamic model or orbit maneuvers. To improve this situation, the sequential estimation Square Root Information Filtering (SRIF was applied to determine the real-time BDS orbits. In the filter algorithm, usually a long period is required for the orbit to converge to the final accuracy, due to lake of accurate initial state. This paper focuses on the impact of the initial state with different a priori Standard Deviation (STD on the BDS orbit convergence performance in both normal and abnormal periods. For the normal period, the Ultra-Rapid (UR orbit products and the Broadcast Ephemerides (BRDC used as initial orbits are discussed respectively. For the abnormal period, orbit maneuver is analyzed. Experimental results show that a proper a priori STD of initial state can significantly accelerate the orbit convergence, while a loose a priori STD takes more than 10 h to converge in the radial direction for the BDS GEO/IGSO/MEO satellites. When the UR orbit product is used as the initial orbit, the orbit of the IGSO/MEO satellites can converge to decimeter-level immediately. When the BRDC product is used, the accuracy of meter-level can be obtained for the IGSO/MEO immediately, and converge to decimeter-level in about 6 h. For the period after the orbit maneuver, the real-time orbit accuracy can reach meter-level in about 6 h after the first group of broadcast ephemerides is received.

  14. Three-frequency BDS precise point positioning ambiguity resolution based on raw observables

    Science.gov (United States)

    Li, Pan; Zhang, Xiaohong; Ge, Maorong; Schuh, Harald

    2018-02-01

    All BeiDou navigation satellite system (BDS) satellites are transmitting signals on three frequencies, which brings new opportunity and challenges for high-accuracy precise point positioning (PPP) with ambiguity resolution (AR). This paper proposes an effective uncalibrated phase delay (UPD) estimation and AR strategy which is based on a raw PPP model. First, triple-frequency raw PPP models are developed. The observation model and stochastic model are designed and extended to accommodate the third frequency. Then, the UPD is parameterized in raw frequency form while estimating with the high-precision and low-noise integer linear combination of float ambiguity which are derived by ambiguity decorrelation. Third, with UPD corrected, the LAMBDA method is used for resolving full or partial ambiguities which can be fixed. This method can be easily and flexibly extended for dual-, triple- or even more frequency. To verify the effectiveness and performance of triple-frequency PPP AR, tests with real BDS data from 90 stations lasting for 21 days were performed in static mode. Data were processed with three strategies: BDS triple-frequency ambiguity-float PPP, BDS triple-frequency PPP with dual-frequency (B1/B2) and three-frequency AR, respectively. Numerous experiment results showed that compared with the ambiguity-float solution, the performance in terms of convergence time and positioning biases can be significantly improved by AR. Among three groups of solutions, the triple-frequency PPP AR achieved the best performance. Compared with dual-frequency AR, additional the third frequency could apparently improve the position estimations during the initialization phase and under constraint environments when the dual-frequency PPP AR is limited by few satellite numbers.

  15. Time synchronization of new-generation BDS satellites using inter-satellite link measurements

    Science.gov (United States)

    Pan, Junyang; Hu, Xiaogong; Zhou, Shanshi; Tang, Chengpan; Guo, Rui; Zhu, Lingfeng; Tang, Guifeng; Hu, Guangming

    2018-01-01

    Autonomous satellite navigation is based on the ability of a Global Navigation Satellite System (GNSS), such as Beidou, to estimate orbits and clock parameters onboard satellites using Inter-Satellite Link (ISL) measurements instead of tracking data from a ground monitoring network. This paper focuses on the time synchronization of new-generation Beidou Navigation Satellite System (BDS) satellites equipped with an ISL payload. Two modes of Ka-band ISL measurements, Time Division Multiple Access (TDMA) mode and the continuous link mode, were used onboard these BDS satellites. Using a mathematical formulation for each measurement mode along with a derivation of the satellite clock offsets, geometric ranges from the dual one-way measurements were introduced. Then, pseudoranges and clock offsets were evaluated for the new-generation BDS satellites. The evaluation shows that the ranging accuracies of TDMA ISL and the continuous link are approximately 4 cm and 1 cm (root mean square, RMS), respectively. Both lead to ISL clock offset residuals of less than 0.3 ns (RMS). For further validation, time synchronization between these satellites to a ground control station keeping the systematic time in BDT was conducted using L-band Two-way Satellite Time Frequency Transfer (TWSTFT). System errors in the ISL measurements were calibrated by comparing the derived clock offsets with the TWSTFT. The standard deviations of the estimated ISL system errors are less than 0.3 ns, and the calibrated ISL clock parameters are consistent with that of the L-band TWSTFT. For the regional BDS network, the addition of ISL measurements for medium orbit (MEO) BDS satellites increased the clock tracking coverage by more than 40% for each orbital revolution. As a result, the clock predicting error for the satellite M1S was improved from 3.59 to 0.86 ns (RMS), and the predicting error of the satellite M2S was improved from 1.94 to 0.57 ns (RMS), which is a significant improvement by a factor of 3-4.

  16. Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine.

    Science.gov (United States)

    He, Dong-Yi; Dai, Sheng-Ming

    2011-01-01

    In China, Korea, and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. A water/ethanol extract of the root is now known as total glucosides of peony (TGP), which contains more than 15 components. Paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed with TGP in both in vitro and in vivo studies. The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. The direct anti-inflammatory effects of TGP were observed in animal models of both acute and subacute inflammation, by inhibiting the production of prostaglandin E2, leukotriene B4, and nitric oxide, and by suppressing the increase of intracellular calcium ion concentration. TGP was also reported to have protective effects of cells against oxidative stress. In vitro, dual effects of TGP were noted on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and the production of proinflammatory cytokines and antibodies. In vivo, TGP inhibited the delayed-type hypersensitivity in immuno-activated mice, and enhanced the delayed-type hypersensitivity in immuno-suppressed mice. In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects. The beneficial effects of TGP in treating rheumatoid arthritis were verified by randomized controlled trials. The adverse events of TGP were mainly gastrointestinal tract disturbances, mostly mild diarrhea.

  17. Total glucosides of Paeonia lactiflora Pall inhibit vascular endothelial growth factor-induced angiogenesis.

    Science.gov (United States)

    Deng, Hui; Yan, Chunlin; Xiao, Tian; Yuan, Dingfen; Xu, Jinhua

    2010-02-17

    To evaluate the anti-angiogenesis effect of total glucosides of Paeonia lactiflora Pall. In this study, we determined the effect of TGP on the proliferation of human vascular endothelial cells through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and fluorescence-activated cell sorting analysis. A migration assay and a tube formation assay were used to investigate the migration properties and tube formation abilities of human vascular endothelial cells after being treated with TGP. Furthermore, the in vivo anti-angiogenic ability of TGP was determined through a chick chorioallantoic membrane assay. TGP (12.5, 62.5, and 312.5 microg/ml) resulted in a dose-dependent reduction in the proliferation of endothelial cells. This inhibition effect began 6h after treatment and lasted at least 24h. Fluorescence-activated cell sorting analysis data showed an accumulation of cells in the G0/G1 phase of the cell cycle, which exhibited apoptotic features indicative of cell death. The migration properties and tube forming abilities of endothelial cells were dramatically inhibited by the TGP extract. Our results show that TGP can inhibit angiogenesis in vitro and in vivo. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

  18. Reproduction, aging and mortality rate in social subterranean mole voles (Ellobius talpinus Pall.).

    Science.gov (United States)

    Novikov, E; Kondratyuk, E; Petrovski, D; Titova, T; Zadubrovskaya, I; Zadubrovskiy, P; Moshkin, M

    2015-12-01

    Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bathyergids or typical of other social subterranean rodents as well. In the present study, we analysed data from observations of a social subterranean Microtinae rodent, the northern mole vole (Ellobius talpinus Pall.), which, like mole-rats, has reproductive skew. Among the individuals captured in the wild and maintained in captivity, females that reproduced lived significantly longer than non-breeding females. We did not find any changes in muscle strength with age in any of the demographic groups studied. Faecal glucocorticoid concentrations before death were significantly higher in non-breeding females than in breeding females and males. Increased adrenocortical activity may be one mechanism responsible for the decreased lifespan of non-reproducing individuals of social subterranean rodents. We conclude that the patterns of aging, although different in some respects, are generally common for social subterranean rodents of different taxonomic groups.

  19. Approaches to gene pool conservation of medicinal plant Oxytropis lanata (Pall. DC. (Fabaceae

    Directory of Open Access Journals (Sweden)

    A. B. Kholina

    2015-05-01

    Full Text Available In order to preserve the gene pool of medicinal plant Oxytropis lanata (Pall. DC. we analyzed allozyme polymorphism and identified reliable and informative marker enzyme systems of this species; also we studied the response of seeds to deep freezing in liquid nitrogen (–196 ºС. Population has an average level of polymorphism (P95 = 41,2 %, P99 = 52,9 %, A = 1,58, Ho = 0,158, He = 0,171 in general typical for herbaceous legumes, and can serve as a source of material for gene pool conservation of the species. Deep freezing has not led to the death of the seeds; it was marked stimulatory effect of ultralow temperatures, expressed as an acceleration of germination and sharp increase of germinability (98,6 ± 2,3 % compared to the control (12,0 ± 3,5 % that is associated with overcoming physical dormancy. There were no abnormalities in the development of seedlings from seeds passed cryopreservation.

  20. Rhizobium helanshanense sp. nov., a bacterium that nodulates Sphaerophysa salsula (Pall.) DC. in China.

    Science.gov (United States)

    Qin, Wei; Deng, Zhen Shan; Xu, Lin; Wang, Na Na; Wei, Ge Hong

    2012-05-01

    Studying rhizobia in the root nodules of Sphaerophysa salsula (Pall.) DC in the northwest of China, we obtained five strains classified as genus Rhizobium on the basis of their 16S rRNA gene sequences. The sequence similarity of strain CCNWQTX14(T) with the most related species was 99.0%. Further phylogenetic analysis of housekeeping genes (recA and atpD) suggested the five strains comprised a novel lineage within Rhizobium. The nifH and nodD gene sequences of CCNWQTX14(T) were phylogenetically closely related with those of Sinorhizobium kummerowiae and R. sphaerophysae, respectively. The five strains isolated from different places were also distinct from related Rhizobium species using ERIC fingerprint profiles. The DNA-DNA hybridization value was 41.8% between CCNWQTX14(T) and Rhizobium sphaerophysae CCNWGS0238(T). Our novel strains were only able to form effective nodules on its original host Sphaerophysa salsula. Our data showed that the five Rhizobium strains formed a unique genomic species, for which a novel species Rhizobium helanshanense sp. nov. is proposed. The type strain is CCNWQTX14(T) (=ACCC 16237(T) =HAMBI 3083(T)).

  1. Comparative study of anxiety index and stress coping skills in first and second year BDS students of Sinhgad Dental College, Pune

    Directory of Open Access Journals (Sweden)

    Rajeev Saxena

    2015-01-01

    Full Text Available Objectives To know the Anxiety index and stress coping skills in first and second year BDS students. Methods 188 students received a pre-validated module by Zung anxiety self-assessment tool, and Coping as measured by “Ways of coping scale by Folkman and Lazarus. Results Overall results show higher anxiety levels amongst first BDS students compared to second BDS. Conclusions Stress coping module should be introduced at the earlier stage i.e. First BDS which would help them to be competent.

  2. Inertial Aided Cycle-slip Detection and Repair for BDS Triple-frequency Signal in Severe Multipath Environment

    Directory of Open Access Journals (Sweden)

    NING Yipeng

    2017-05-01

    Full Text Available Inertial information has been proposed to improve the success rate and repair rate for BDS triple-frequency cycle-slip detection in severe environment with multipath effects.At the same time, a BDS/INS loose coupled model has been developed. An innovative INS aided BDS triple-frequency combination method was developed which based on the traditional method of code-phase combination and geometry-free linear combination. The INS aided cycle-slip detection monitoring value was established and the effect of INS positioning error on cycle-slip capacity was analyzed. The proposed method overcomes the shortcoming of cycle-slip detection capacity influenced by the pseudorange observation precision. It also realizes small cycle-slips detection for BDS in severe multipath effects environment. At last, a field test was analysised with INS/BDS triple-frequency integrated positioning system onboard. The results indicate that the method proposed in this paper shows a high cycle-slip detection success rate and repair rate, when traditional triple-frequency detection model losed efficacy above water surface with multipath effects, and it also can be effective in low frequency sampling data.

  3. The study and realization of BDS un-differenced network-RTK based on raw observations

    Science.gov (United States)

    Tu, Rui; Zhang, Pengfei; Zhang, Rui; Lu, Cuixian; Liu, Jinhai; Lu, Xiaochun

    2017-06-01

    A BeiDou Navigation Satellite System (BDS) Un-Differenced (UD) Network Real Time Kinematic (URTK) positioning algorithm, which is based on raw observations, is developed in this study. Given an integer ambiguity datum, the UD integer ambiguity can be recovered from Double-Differenced (DD) integer ambiguities, thus the UD observation corrections can be calculated and interpolated for the rover station to achieve the fast positioning. As this URTK model uses raw observations instead of the ionospheric-free combinations, it is applicable for both dual- and single-frequency users to realize the URTK service. The algorithm was validated with the experimental BDS data collected at four regional stations from day of year 080 to 083 in 2016. The achieved results confirmed the high efficiency of the proposed URTK for providing the rover users a rapid and precise positioning service compared to the standard NRTK. In our test, the BDS URTK can provide a positioning service with cm level accuracy, i.e., 1 cm in the horizontal components, and 2-3 cm in the vertical component. Within the regional network, the mean convergence time for the users to fix the UD ambiguities is 2.7 s for the dual-frequency observations and of 6.3 s for the single-frequency observations after the DD ambiguity resolution. Furthermore, due to the feature of realizing URTK technology under the UD processing mode, it is possible to integrate the global Precise Point Positioning (PPP) and the local NRTK into a seamless positioning service.

  4. Multi-GNSS phase delay estimation and PPP ambiguity resolution: GPS, BDS, GLONASS, Galileo

    Science.gov (United States)

    Li, Xingxing; Li, Xin; Yuan, Yongqiang; Zhang, Keke; Zhang, Xiaohong; Wickert, Jens

    2017-10-01

    This paper focuses on the precise point positioning (PPP) ambiguity resolution (AR) using the observations acquired from four systems: GPS, BDS, GLONASS, and Galileo (GCRE). A GCRE four-system uncalibrated phase delay (UPD) estimation model and multi-GNSS undifferenced PPP AR method were developed in order to utilize the observations from all systems. For UPD estimation, the GCRE-combined PPP solutions of the globally distributed MGEX and IGS stations are performed to obtain four-system float ambiguities and then UPDs of GCRE satellites can be precisely estimated from these ambiguities. The quality of UPD products in terms of temporal stability and residual distributions is investigated for GPS, BDS, GLONASS, and Galileo satellites, respectively. The BDS satellite-induced code biases were corrected for GEO, IGSO, and MEO satellites before the UPD estimation. The UPD results of global and regional networks were also evaluated for Galileo and BDS, respectively. As a result of the frequency-division multiple-access strategy of GLONASS, the UPD estimation was performed using a network of homogeneous receivers including three commonly used GNSS receivers (TRIMBLE NETR9, JAVAD TRE_G3TH DELTA, and LEICA). Data recorded from 140 MGEX and IGS stations for a 30-day period in January in 2017 were used to validate the proposed GCRE UPD estimation and multi-GNSS dual-frequency PPP AR. Our results show that GCRE four-system PPP AR enables the fastest time to first fix (TTFF) solutions and the highest accuracy for all three coordinate components compared to the single and dual system. An average TTFF of 9.21 min with 7{°} cutoff elevation angle can be achieved for GCRE PPP AR, which is much shorter than that of GPS (18.07 min), GR (12.10 min), GE (15.36 min) and GC (13.21 min). With observations length of 10 min, the positioning accuracy of the GCRE fixed solution is 1.84, 1.11, and 1.53 cm, while the GPS-only result is 2.25, 1.29, and 9.73 cm for the east, north, and vertical

  5. Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine

    Directory of Open Access Journals (Sweden)

    Dong-Yi eHe

    2011-02-01

    Full Text Available In China, Korea and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. A water/ethanol extract of the root is now known as total glucosides of paeony (TGP, which contains more than 15 components. Paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed with TGP in both in vitro and in vivo studies. The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. The direct anti-inflammatory effects of TGP were observed in animal models of both acute and subacute inflammation, by inhibiting the production of prostaglandin E2, leukotrience B4, and nitric oxide, and by suppressing the increase of intracellular calcium ion concentration. TGP was also reported to have protective effects of cells against oxidative stress. In vitro, dual effects of TGP were noted on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and the production of pro-inflammatory cytokines and antibodies. In vivo, TGP inhibited the delayed-type hypersensitivity in immuno-activated mice, and enhanced the delayed-type hypersensitivity in immuno-suppressed mice. In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects. The beneficial effects of TGP in treating rheumatoid arthritis were verified by randomized controlled trials. The adverse events of TGP were mainly gastrointestinal tract disturbances, mostly mild diarrhea.

  6. Effects of total glucosides from paeony (Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats.

    Science.gov (United States)

    Li, Jing; Chen, Chang Xun; Shen, Yun Hui

    2011-05-17

    Total glucosides of paeony (TGP), compounds extracted from the roots of Paeonia lactiflora Pall, have been used as an anti-inflammatory drug for the treatment of rheumatoid arthritis (RA) in China. Inflammation plays a critical role in the development of atherosclerotic vascular disease. Risk of cardiovascular diseases is significantly higher in patients with RA than in normal population. It has a great significance to study the effects of TGP on atherosclerosis. To investigate the effects of TGP on atherosclerosis induced by excessive administration of vitamin D and cholesterol in rats and study the mechanisms involved. Atherosclerosis was induced by excessive administration of vitamin D and cholesterol in rats. TGP was intragastrically administered for 15 weeks. The serum concentrations of total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were measured by automatic biochemistry analyzer. Apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) were determined by immunoturbidimetry method, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay (ELISA) method. The morphological changes of aorta were observed with optical microscopy. Compared to controls, TGP significantly lowered the serum level of TC, TG, LDL-C, ApoB, TNF-alpha, IL-6 and CRP, increased the ratios of HDL-C/LDL-C and ApoA1/ApoB, decreased the intima-media thickness (IMT) of abdominal aortal wall and improved the morphological change of the aorta. TGP may attenuate the development of atherosclerotic disease. The beneficial effects are associated with its lowering blood lipids and inhibiting the expression of inflammatory cytokines. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  7. Herbaceous Peony (Paeonia lactiflora Pall. as an Alternative Source of Oleanolic and Ursolic Acids

    Directory of Open Access Journals (Sweden)

    Jun Tao

    2011-01-01

    Full Text Available Oleanolic acid (OA and ursolic acid (UA have been proven to possess many biological activities, and much attention is focused on the search for plants which are rich in OA and UA. In this report, the OA and UA accumulation characteristics were investigated in 47 cultivars of Chinese herbaceous peony (Paeonia lactiflora Pall. and were followed in three cultivars over different developmental stages as measured by high performance liquid chromatography (HPLC. OA and UA levels in leaves and stems demonstrated an overall upward trend from May 1 to September 15 except for UA in the leaves of “Hong Feng”. The maximum values of OA and UA in leaves of “Yangfei Chu Yu”, “Fen Zhu Pan” and “Hong Feng” were 852.98, 575.60, 290.48 μg/g FW and 924.94, 827.36, 432.67 μg/g FW, respectively. The maximum values of OA and UA in stems of “Yangfei Chu Yu”, “Fen Zhu Pan” and “Hong Feng” were 359.28, 90.49, 43.90 μg/g FW and 326.86, 82.25, 56.63 μg/g FW, respectively. OA and UA contents in leaves of 47 different herbaceous peony cultivars ranged from 66.73–618.12 and 36.23–665.14 μg/g FW, respectively, with average values of 171.62 and 227.57 μg/g FW, respectively. The results suggested that the aboveground parts of herbaceous peony may be used as an alternative source of OA and UA for medicinal purposes in addition to its ornamental purposes.

  8. High-Precision Ionosphere Monitoring Using Continuous Measurements from BDS GEO Satellites

    Directory of Open Access Journals (Sweden)

    Haiyan Yang

    2018-02-01

    Full Text Available The current constellation of the BeiDou Navigation Satellite System (BDS consists of five geostationary earth orbit (GEO satellites, five inclined geosynchronous satellite orbit (IGSO satellites, and four medium earth orbit (MEO satellites. The advantage of using GEO satellites to monitor the ionosphereis the almost motionless ionospheric pierce point (IPP, which is analyzed in comparison with the MEO and IGSO satellites. The results from the analysis of the observations using eight tracking sites indicate that the ionospheric total electron content (TEC sequence derived from each GEO satellite at their respective fixed IPPs is always continuous. The precision of calculated vertical TEC (VTEC using BDS B1/B2, B1/B3, and B2/B3 dual-frequency combinationsis compared and analyzed. The VTEC12 precision based on the B1/B2 dual-frequency measurements using the smoothed code and the raw code combination is 0.69 and 5.54 TECU, respectively, which is slightly higher than VTEC13 and much higher than VTEC23. Furthermore, the ionospheric monitoring results of site JFNG in the northern hemisphere, and CUT0 in the southern hemisphere during the period from 1 January to 31 December 2015 are presented and discussed briefly.

  9. High-Precision Ionosphere Monitoring Using Continuous Measurements from BDS GEO Satellites.

    Science.gov (United States)

    Yang, Haiyan; Yang, Xuhai; Zhang, Zhe; Zhao, Kunjuan

    2018-02-27

    The current constellation of the BeiDou Navigation Satellite System (BDS) consists of five geostationary earth orbit (GEO) satellites, five inclined geosynchronous satellite orbit (IGSO) satellites, and four medium earth orbit (MEO) satellites. The advantage of using GEO satellites to monitor the ionosphereis the almost motionless ionospheric pierce point (IPP), which is analyzed in comparison with the MEO and IGSO satellites. The results from the analysis of the observations using eight tracking sites indicate that the ionospheric total electron content (TEC) sequence derived from each GEO satellite at their respective fixed IPPs is always continuous. The precision of calculated vertical TEC (VTEC) using BDS B1/B2, B1/B3, and B2/B3 dual-frequency combinationsis compared and analyzed. The VTEC 12 precision based on the B1/B2 dual-frequency measurements using the smoothed code and the raw code combination is 0.69 and 5.54 TECU, respectively, which is slightly higher than VTEC 13 and much higher than VTEC 23 . Furthermore, the ionospheric monitoring results of site JFNG in the northern hemisphere, and CUT0 in the southern hemisphere during the period from 1 January to 31 December 2015 are presented and discussed briefly.

  10. Preface: BeiDou Navigation Satellite System (BDS)/GNSS+: New developments and emerging applications

    Science.gov (United States)

    Jin, Shuanggen

    2017-12-01

    The China's BeiDou Navigation Satellite System (BDS) has been developed and operated well with over 25 launched satellites in 2017, including fifteen Medium Earth orbit (MEO) satellites, five geostationary Earth orbit (GEO) satellites and five inclined geosynchronous orbit (IGSO) satellites. Together with the United States' GPS, European Union's Galileo and Russia's GLONASS as well as other regional augmentation systems, e.g., Indian Regional Navigation Satellite System (IRNSS) and Japan Quasi-Zenith Satellite System (QZSS), more emerging applications of multi-Global Navigation Satellite Systems (GNSS) will be exploited and realized in the coming years. The papers in this issue of Advances in Space Research present new advances in the system, techniques and emerging applications of BDS/GNSS+. These papers were from an open call and a special call for participants at the 8th China Satellite Navigation Conference (CSNC 2017) held on May 23-25, 2017, Shanghai, China. This conference series provides a good platform for academic and technique exchanges as well as collaboration in satellite navigation. CSNC 2017 was well attend with more than 3000 participants and over 800 papers in 12 sessions.

  11. A Police and Insurance Joint Management System Based on High Precision BDS/GPS Positioning

    Directory of Open Access Journals (Sweden)

    Wenwei Zuo

    2018-01-01

    Full Text Available Car ownership in China reached 194 million vehicles at the end of 2016. The traffic congestion index (TCI exceeds 2.0 during rush hour in some cities. Inefficient processing for minor traffic accidents is considered to be one of the leading causes for road traffic jams. Meanwhile, the process after an accident is quite troublesome. The main reason is that it is almost always impossible to get the complete chain of evidence when the accident happens. Accordingly, a police and insurance joint management system is developed which is based on high precision BeiDou Navigation Satellite System (BDS/Global Positioning System (GPS positioning to process traffic accidents. First of all, an intelligent vehicle rearview mirror terminal is developed. The terminal applies a commonly used consumer electronic device with single frequency navigation. Based on the high precision BDS/GPS positioning algorithm, its accuracy can reach sub-meter level in the urban areas. More specifically, a kernel driver is built to realize the high precision positioning algorithm in an Android HAL layer. Thus the third-party application developers can call the general location Application Programming Interface (API of the original standard Global Navigation Satellite System (GNSS to get high precision positioning results. Therefore, the terminal can provide lane level positioning service for car users. Next, a remote traffic accident processing platform is built to provide big data analysis and management. According to the big data analysis of information collected by BDS high precision intelligent sense service, vehicle behaviors can be obtained. The platform can also automatically match and screen the data that uploads after an accident to achieve accurate reproduction of the scene. Thus, it helps traffic police and insurance personnel to complete remote responsibility identification and survey for the accident. Thirdly, a rapid processing flow is established in this article to

  12. A Police and Insurance Joint Management System Based on High Precision BDS/GPS Positioning.

    Science.gov (United States)

    Zuo, Wenwei; Guo, Chi; Liu, Jingnan; Peng, Xuan; Yang, Min

    2018-01-10

    Car ownership in China reached 194 million vehicles at the end of 2016. The traffic congestion index (TCI) exceeds 2.0 during rush hour in some cities. Inefficient processing for minor traffic accidents is considered to be one of the leading causes for road traffic jams. Meanwhile, the process after an accident is quite troublesome. The main reason is that it is almost always impossible to get the complete chain of evidence when the accident happens. Accordingly, a police and insurance joint management system is developed which is based on high precision BeiDou Navigation Satellite System (BDS)/Global Positioning System (GPS) positioning to process traffic accidents. First of all, an intelligent vehicle rearview mirror terminal is developed. The terminal applies a commonly used consumer electronic device with single frequency navigation. Based on the high precision BDS/GPS positioning algorithm, its accuracy can reach sub-meter level in the urban areas. More specifically, a kernel driver is built to realize the high precision positioning algorithm in an Android HAL layer. Thus the third-party application developers can call the general location Application Programming Interface (API) of the original standard Global Navigation Satellite System (GNSS) to get high precision positioning results. Therefore, the terminal can provide lane level positioning service for car users. Next, a remote traffic accident processing platform is built to provide big data analysis and management. According to the big data analysis of information collected by BDS high precision intelligent sense service, vehicle behaviors can be obtained. The platform can also automatically match and screen the data that uploads after an accident to achieve accurate reproduction of the scene. Thus, it helps traffic police and insurance personnel to complete remote responsibility identification and survey for the accident. Thirdly, a rapid processing flow is established in this article to meet the

  13. A Kalman Filter-Based Short Baseline RTK Algorithm for Single-Frequency Combination of GPS and BDS

    Directory of Open Access Journals (Sweden)

    Sihao Zhao

    2014-08-01

    Full Text Available The emerging Global Navigation Satellite Systems (GNSS including the BeiDou Navigation Satellite System (BDS offer more visible satellites for positioning users. To employ those new satellites in a real-time kinematic (RTK algorithm to enhance positioning precision and availability, a data processing model for the dual constellation of GPS and BDS is proposed and analyzed. A Kalman filter-based algorithm is developed to estimate the float ambiguities for short baseline scenarios. The entire work process of the high-precision algorithm based on the proposed model is deeply investigated in detail. The model is validated with real GPS and BDS data recorded from one zero and two short baseline experiments. Results show that the proposed algorithm can generate fixed baseline output with the same precision level as that of either a single GPS or BDS RTK algorithm. The significantly improved fixed rate and time to first fix of the proposed method demonstrates a better availability and effectiveness on processing multi-GNSSs.

  14. A Kalman filter-based short baseline RTK algorithm for single-frequency combination of GPS and BDS.

    Science.gov (United States)

    Zhao, Sihao; Cui, Xiaowei; Guan, Feng; Lu, Mingquan

    2014-08-20

    The emerging Global Navigation Satellite Systems (GNSS) including the BeiDou Navigation Satellite System (BDS) offer more visible satellites for positioning users. To employ those new satellites in a real-time kinematic (RTK) algorithm to enhance positioning precision and availability, a data processing model for the dual constellation of GPS and BDS is proposed and analyzed. A Kalman filter-based algorithm is developed to estimate the float ambiguities for short baseline scenarios. The entire work process of the high-precision algorithm based on the proposed model is deeply investigated in detail. The model is validated with real GPS and BDS data recorded from one zero and two short baseline experiments. Results show that the proposed algorithm can generate fixed baseline output with the same precision level as that of either a single GPS or BDS RTK algorithm. The significantly improved fixed rate and time to first fix of the proposed method demonstrates a better availability and effectiveness on processing multi-GNSSs.

  15. Cooperating the BDS, GPS, GLONASS and strong-motion observations for real-time deformation monitoring

    Science.gov (United States)

    Tu, Rui

    2017-04-01

    An approach of cooperating the BDS, GPS, GLONASS and Strong-Motion (SM) records for real-time deformation monitoring was presented, and it was validated by an experiment data. For this approach, the GNSS data was processed by the RTK technology to retrieve the GNSS displacement, and the SM data was calibrated to get the raw acceleration, a Kalman filter was used to combine the GNSS displacement and the SM acceleration to obtain the integrated displacement, velocity and acceleration. The validation results show that the advantages of each sensors are completely complement; for the SM, the baseline shifts are estimated and corrected, high-precision velocity and displacement are recovered, and for the GNSS, the SM's high-resolution acceleration are used to reduce the GNSS noise, thus high-precision and broadband deformation information can be real-time obtained, it will be useful for the high-building, dam, bridge, landslide's deformation monitoring.

  16. Observation Weight Function Design for Fusing BDS/GPS Data to Estimate the Real-time Clock with Regard to the Orbit Errors

    Directory of Open Access Journals (Sweden)

    GU Shouzhou

    2017-05-01

    Full Text Available The real-time clock product is one of the basis products for wide-area positioning service of high precision. Considering the difference between BDS orbit precision and GPS precision, we design a new observation weight function, in order to optimize the stochastic model of real time BDS/GPS clock estimation. The BDS/GPS observations of 78 MGEX global stations and 2 iGMAS stations were collected to generate the real time clock, and then the calculation results were compared with the final iGMAS precise clock product in two strategies (the old stochastic model and the new stochastic model.It shows that the method based the proposed stochastic model can improve the precision of satellite clock about 9% for GPS and 10%for BDS.

  17. Analysis on BDS Satellite Internal Multipath and Its Impact on Wide-lane FCB Estimation

    Directory of Open Access Journals (Sweden)

    RUAN Rengui

    2017-08-01

    Full Text Available To the issue of the satellite internal multipath (SIMP of BeiDou satellites, it proposed and emphasized that the SIMP model should be established as a function of the nadir angle with respect to the observed satellite rather than the elevation of the measurement, so that it can be used for receivers at various altitude. BDS data from global distributed stations operated by the International Monitoring and Assessment System (iGMAS and the Multi-GNSS Experiment (MGEX of the International GNSS Service (IGS are collected and a new SIMP model as a piece-wise linear function of the nadir angle is released for the IGSO-and MEO-satellite groups and for B1, B2 and B3 frequency band individually. The SIMP of GEO,IGSO and MEO satellites is further analyzed with B1/B2 dual-frequency data onboard the FengYun-3 C(FY3C satellite at an altitude of~830 km, and it showed that, for nadir angles smaller than 7°, the SIMP values for GEO is quite close to the IGSO's, especially for B2, which may suggest that the SIMP model for IGSO satellites possibly also works for GEO satellites. It also demonstrated that, when the nadir angle is smaller than 12°for the MEO and 7°for the IGSO, the estimated SIMP model with data from FY3C is considerable consistent with that estimated with data collected at ground stations. Experiments are carried out to investigate the impacts of the SIMP on wide-lane fractional cycle bias (FCB estimation for BDS satellites. The result indicates that, with the correction of the estimated SIMP, the repeatability of the FCB series is significantly improved by more than 60% for all satellites. Specifically, for the MEO and IGSO satellites, the repeatability is smaller than 0.05 cycle; the repeatability of 0.023 and 0.068 cycles achieved for GEO satellites C01 and C02 respectively with the estimated SIMP model for IGSO satellites.

  18. Kinematic Orbit Determination Method Optimization and Test Analysis for BDS Satellites with Short-arc Tracking Data

    Directory of Open Access Journals (Sweden)

    GUO Rui

    2017-04-01

    Full Text Available Rapid orbit recovery is a puzzle for the BDS satellites after orbit maneuvers. Two kinematic orbit determination methods are studied, with two orbit determination models being established. The receiver system error and serious multipath error exist in the BDS system. The co-location method is proposed to estimate and calibrate the receiver system errors. A CNMC (code noise and multipath correction method is introduced to weaken the multipath error. Therefore the data quality is controlled efficiently for the receivers in the short tracking arc. The GEO/IGSO/MEO real data is emploied to carry out tests and validation. Using 10 min short tracking arc, the kinematic precise orbit determination accuracy is about 3.27 m for the GEOs, and 8.19 m for the IGSOs, and 5.9 m for the MEOs. Rapid orbit determination is achieved, which satisfying the orbit requirements from the BDS RDSS services. The kinematic precise orbit determination method also supports the RDSS service walking up to the global world.

  19. Perception of BDS students and fresh graduates about significance of professional ethics in dentistry.

    Science.gov (United States)

    Al-Zain, Sahar Asaad; Al-Sadhan, Salwa Abdul Rahman; Ahmedani, Muhammad Shoaib

    2014-02-01

    To assess the awareness level of undergraduate dentistry students as well as fresh graduates about the significance of professional ethics. The cross sectional study was conducted among the 3rd, 4th and final year male and female BDS students as well as fresh graduate Interns from the College of Dentistry, King Saud University from January to June 2011. The students were asked to give their opinion about need for applications of professional ethics in dental practice on a five point Likert Scale varying from 'strongly agree' to 'strongly disagree'. Minitab statistical software was used for data analysis. Students at all levels considered professional ethics a very important prerequisite for dental practice with overall mean value of 4.42 +/- 0.36. However, the responses from the senior academic levels were significantly on the higher side compared to those from the junior grades. Generally the religious teachings and spirituality was considered as one of the top most motives for practicing professional ethics in dentistry followed by reputation, financial benefits, fear of punishment and self projection, with overall mean values of 3.93 +/- 0.58, 3.81 +/- 0.49, 3.25 +/- 0.94, 3.21 +/- 1.07 and 3.16 +/- 1.04, respectively. The present findings revealed that Professional Ethics is appreciated by the students as a highly significant factor for their success in dental practice as well as acquiring a good name and position in the society.

  20. Perception of BDS students and fresh graduates about significance of professional ethics in dentistry

    International Nuclear Information System (INIS)

    Zain, S.A.A.; Sadhan, S.A.R.A.; Ahmedani, M.S.

    2014-01-01

    Objective: To assess the awareness level of undergraduate dentistry students as well as fresh graduates about the significance of professional ethics. Methods: The cross sectional study was conducted among the 3rd, 4th and final year male and female BDS students as well as fresh graduate Interns from the College of Dentistry, King Saud University from January to June 2011. The students were asked to give their opinion about need for applications of professional ethics in dental practice on a five point Likert Scale varying from strongly agree to strongly disagree. Minitab statistical software was used for data analysis. Results: Students at all levels considered professional ethics a very important prerequisite for dental practice with overall mean value of 4.42+-0.36. However, the responses from the senior academic levels were significantly on the higher side compared to those from the junior grades. Generally the religious teachings and spirituality was considered as one of the top most motives for practicing professional ethics in dentistry followed by reputation, financial benefits, fear of punishment and self projection, with overall mean values of 3.93+-0.58, 3.81+-0.49, 3.25+-0.94, 3.21+-1.07 and 3.16+-1.04, respectively. Conclusion: The present findings revealed that Professional Ethics is appreciated by the students as a highly significant factor for their success in dental practice as well as acquiring a good name and position in the society. (author)

  1. Cooperating the BDS, GPS, GLONASS and strong-motion observations for real-time deformation monitoring

    Science.gov (United States)

    Tu, Rui; Liu, Jinhai; Lu, Cuixian; Zhang, Rui; Zhang, Pengfei; Lu, Xiaochun

    2017-06-01

    An approach of cooperating the BDS, GPS, GLONASS and strong-motion (SM) records for real-time deformation monitoring was presented, which was validated by the experimental data. In this approach, the Global Navigation Satellite System (GNSS) data were processed with the real-time kinematic positioning technology to retrieve the GNSS displacement, and the SM data were calibrated to acquire the raw acceleration; a Kalman filter was then applied to combine the GNSS displacement and the SM acceleration to obtain the integrated displacement, velocity and acceleration. The validation results show that the advantages of each sensor are completely complementary. For the SM, the baseline shifts are estimated and corrected, and the high-precision velocity and displacement are recovered. While the noise of GNSS can be reduced by using the SM-derived high-resolution acceleration, thus the high-precision and broad-band deformation information can be obtained in real time. The proposed method indicates a promising potential and capability in deformation monitoring of the high-building, dam, bridge and landslide.

  2. LHCb: Measurement of the relative yields of the decay modes $B_{d,s} \\to D^{\\pm}_{(s)}\\pi^{\\mp}$ and $B_{d,s} \\to D^{\\pm}_{(s)} K^{\\pm}$ and determination of $f_d /f_s$ for 7 TeV $pp$ collisions

    CERN Multimedia

    David, P; Morawski, P; Witek, M; Akiba, K; Serra, N; Storaci, B; Tuning, N; Williams, M; Easo, S; Carson, L; Poluektov, A

    2011-01-01

    A fit to the invariant mass distributions is used to determine the relative abundances of the four decay modes $B_{d,s} \\to D^{\\pm}_{(s)}\\pi^{\\mp}$ and $B_{d,s} \\to D^{\\pm}_{(s)} K^{\\mp}$ for $B_{d,s}$ mesons produced in 7 TeV $pp$ collisions at the LHC. From these, the relative branching fractions of the kaon modes with respect to the pion modes, and the value of $f_d /f_s$, are determined.

  3. Evaluation on the impact of IMU grades on BDS + GPS PPP/INS tightly coupled integration

    Science.gov (United States)

    Gao, Zhouzheng; Ge, Maorong; Shen, Wenbin; Li, You; Chen, Qijin; Zhang, Hongping; Niu, Xiaoji

    2017-09-01

    The unexpected observing environments in dynamic applications may lead to partial and/or complete satellite signal outages frequently, which can definitely impact on the positioning performance of the Precise Point Positioning (PPP) in terms of decreasing available satellite numbers, breaking the continuity of observations, and degrading PPP's positioning accuracy. Generally, both the Inertial Navigation System (INS) and the multi-constellation Global Navigation Satellite System (GNSS) can be used to enhance the performance of PPP. This paper introduces the mathematical models of the multi-GNSS PPP/INS Tightly Coupled Integration (TCI), and investigates its performance from several aspects. Specifically, it covers (1) the use of the BDS/GPS PPP, PPP/INS, and their combination; (2) three positioning modes including PPP, PPP/INS TCI, and PPP/INS Loosely Coupled Integration (LCI); (3) the use of four various INS systems named navigation grade, tactical grade, auto grade, and Micro-Electro-Mechanical-Sensors (MEMS) one; (4) three PPP observation scenarios including PPP available, partially available, and fully outage. According to the statistics results, (1) the positioning performance of the PPP/INS (either TCI or LCI) mode is insignificantly depended on the grade of inertial sensor, when there are enough available satellites; (2) after the complete GNSS outages, the TCI mode expresses both higher convergence speed and more accurate positioning solutions than the LCI mode. Furthermore, in the TCI mode, using a higher grade inertial sensor is beneficial for the PPP convergence; (3) under the partial GNSS outage situations, the PPP/INS TCI mode position divergence speed is also restrained significantly; and (4) the attitude determination accuracy of the PPP/INS integration is highly correlated with the grade of inertial sensor.

  4. Ex situ conservation of genetic resources of field elm (Ulmus minor Mill and European white elm (Ulmus laevis Pall

    Directory of Open Access Journals (Sweden)

    Aleksić Jelena

    2004-01-01

    Full Text Available Principles of the conservation of genetic resources of elms (Ulmus spp do not differ fundamentally from the general principles accepted for the conservation of genetic resources of other common Noble Hardwoods. Efficient conservation can best be achieved through appropriate combination of in situ and ex situ methods, which have distinct advantages. Besides that, ex situ conservation is employed when emergency measures are needed for rare endangered populations and when populations are too small to be managed in situ (e.g. risks of genetic drift and inbreeding. The aim of our research is ex situ conservation of genetic resources of field elm {Ulmus minor Mill and European white elm (Ulmus laevis Pall through establishment of field genebanks. Sampling was conducted in one population of field elm and one population of white elm. Plant material (buds from 8 trees of field elm and 10 trees of white elm was used for in vitro production of clones. Obtained clones will be used for establishment of field genebanks on the experimental estate of the Institute of Lowland Forestry and Environment.

  5. Low-cost, 4-system, precise GNSS positioning: a GPS, Galileo, BDS and QZSS ionosphere-weighted RTK analysis

    Science.gov (United States)

    Odolinski, Robert; Teunissen, Peter J. G.

    2017-12-01

    With the combination of emerging GNSSs, single-frequency (SF) precise RTK positioning becomes possible. In this contribution we evaluate such low-cost ublox receiver and antenna performance when combining real data of four CDMA systems, namely L1 GPS, E1 Galileo, L1 QZSS, and B1 BDS. Comparisons are made to more expensive dual-frequency (DF) GPS receivers and antennas. The formal and empirical ambiguity success rates and positioning precisions will first be evaluated while making use of L1+E1, so as to investigate whether instantaneous SF RTK is possible without the need of B1 BDS or L1 QZSS. This is followed by an analysis of the SF 4-system model performance when the residual ionosphere can be ignored and modeled as a function of the baseline length, respectively. The analyses are conducted for a location in Dunedin, New Zealand, and compared to Perth, Australia with the better visibility of BDS and QZSS. The results indicate that successful instantaneous and precise RTK positioning is feasible while using L1 GPS and E1 Galileo data, and that the SF 4-system model is competitive to DF GPS even when residual ionospheric delays are present. We finally demonstrate that when the impact from the ionosphere increases and more than one epoch is needed for successful ambiguity resolution, the SF 4-system model performance can still remain competitive with the DF GPS receivers. This is particularly true in Perth with more satellites and when higher than customary elevation cut-off angles need to be used to avoid low-elevation multipath.

  6. Identification of miRNAs Responsive to Botrytis cinerea in Herbaceous Peony (Paeonia lactiflora Pall. by High-Throughput Sequencing

    Directory of Open Access Journals (Sweden)

    Daqiu Zhao

    2015-09-01

    Full Text Available Herbaceous peony (Paeonia lactiflora Pall., one of the world’s most important ornamental plants, is highly susceptible to Botrytis cinerea, and improving resistance to this pathogenic fungus is a problem yet to be solved. MicroRNAs (miRNAs play an essential role in resistance to B. cinerea, but until now, no studies have been reported concerning miRNAs induction in P. lactiflora. Here, we constructed and sequenced two small RNA (sRNA libraries from two B. cinerea-infected P. lactiflora cultivars (“Zifengyu” and “Dafugui” with significantly different levels of resistance to B. cinerea, using the Illumina HiSeq 2000 platform. From the raw reads generated, 4,592,881 and 5,809,796 sRNAs were obtained, and 280 and 306 miRNAs were identified from “Zifengyu” and “Dafugui”, respectively. A total of 237 conserved and 7 novel sequences of miRNAs were differentially expressed between the two cultivars, and we predicted and annotated their potential target genes. Subsequently, 7 differentially expressed candidate miRNAs were screened according to their target genes annotated in KEGG pathways, and the expression patterns of miRNAs and corresponding target genes were elucidated. We found that miR5254, miR165a-3p, miR3897-3p and miR6450a might be involved in the P. lactiflora response to B. cinerea infection. These results provide insight into the molecular mechanisms responsible for resistance to B. cinerea in P. lactiflora.

  7. Single-frequency, dual-GNSS versus dual-frequency, single-GNSS: a low-cost and high-grade receivers GPS-BDS RTK analysis

    Science.gov (United States)

    Odolinski, Robert; Teunissen, Peter J. G.

    2016-11-01

    The concept of single-frequency, dual-system (SF-DS) real-time kinematic (RTK) positioning has become feasible since, for instance, the Chinese BeiDou Navigation Satellite System (BDS) has become operational in the Asia-Pacific region. The goal of the present contribution is to investigate the single-epoch RTK performance of such a dual-system and compare it to a dual-frequency, single-system (DF-SS). As the SF-DS we investigate the L1 GPS + B1 BDS model, and for DF-SS we take L1, L2 GPS and B1, B2 BDS, respectively. Two different locations in the Asia-Pacific region are analysed with varying visibility of the BDS constellation, namely Perth in Australia and Dunedin in New Zealand. To emphasize the benefits of such a model we also look into using low-cost ublox single-frequency receivers and compare such SF-DS RTK performance to that of a DF-SS, based on much more expensive survey-grade receivers. In this contribution a formal and empirical analysis is given. It will be shown that with the SF-DS higher elevation cut-off angles than the conventional 10° or 15° can be used. The experiment with low-cost receivers for the SF-DS reveals (for the first time) that it has the potential to achieve comparable ambiguity resolution performance to that of a DF-SS (L1, L2 GPS), based on the survey-grade receivers.

  8. Near real-time PPP-based monitoring of the ionosphere using dual-frequency GPS/BDS/Galileo data

    Science.gov (United States)

    Liu, Zhinmin; Li, Yangyang; Li, Fei; Guo, Jinyun

    2018-03-01

    Ionosphere delay is very important to GNSS observations, since it is one of the main error sources which have to be mitigated even eliminated in order to determine reliable and precise positions. The ionosphere is a dispersive medium to radio signal, so the value of the group delay or phase advance of GNSS radio signal depends on the signal frequency. Ground-based GNSS stations have been used for ionosphere monitoring and modeling for a long time. In this paper we will introduce a novel approach suitable for single-receiver operation based on the precise point positioning (PPP) technique. One of the main characteristic is that only carrier-phase observations are used to avoid particular effects of pseudorange observations. The technique consists of introducing ionosphere ambiguity parameters obtained from PPP filter into the geometry-free combination of observations to estimate ionospheric delays. Observational data from stations that are capable of tracking the GPS/BDS/GALILEO from the International GNSS Service (IGS) Multi-GNSS Experiments (MGEX) network are processed. For the purpose of performance validation, ionospheric delays series derived from the novel approach are compared with the global ionospheric map (GIM) from Ionospheric Associate Analysis Centers (IAACs). The results are encouraging and offer potential solutions to the near real-time ionosphere monitoring.

  9. An Extended ADOP for Performance Evaluation of Single-Frequency Single-Epoch Positioning by BDS/GPS in Asia-Pacific Region

    Directory of Open Access Journals (Sweden)

    Xin Liu

    2017-09-01

    Full Text Available Single-Frequency Single-Epoch (SFSE high-precision positioning has always been the hot spot of Global Navigation Satellite System (GNSS, and ambiguity dilution of precision (ADOP is a well-known scalar measure for success rate of ambiguity resolution. Traditional ADOP expression is complicated, thus the SFSE extended ADOP (E-ADOP, with the newly defined Summation-Multiplication Ratio of Weight (SMRW and two theorems for short baseline, was developed. This simplifies the ADOP expression; gives a clearer insight into the influences of SMRW and number of satellites on E-ADOP; and makes theoretical analysis of E-ADOP more convenient than that of ADOP, and through that the E-ADOP value can be predicted more accurately than through the ADOP expression for ADOP value. E-ADOP reveals that number of satellites and SMRW or high-elevation satellite are important for ADOP and, through E-ADOP, we studied which factor is dominant to control ADOP in different conditions and make ADOP different between BeiDou Navigation Satellite System (BDS, Global Positioning System (GPS, and BDS/GPS. Based on experimental results of SFSE positioning with different baselines, some conclusions are made: (1 ADOP decreases when new satellites are added mainly because the number of satellites becomes larger; (2 when the number of satellites is constant, ADOP is mainly affected by SMRW; (3 in contrast to systems where the satellites with low-elevation are the majority or where low- and high-elevation satellites are equally distributed, in systems where the high-elevation satellites are the majority, the SMRW mainly makes ADOP smaller, even if there are fewer satellites than in the two previous cases, and the difference in numbers of satellites can be expanded as the proportion of high-elevation satellites becomes larger; and (4 ADOP of BDS is smaller than ADOP of GPS mainly because of its SMRW.

  10. Petrography and Geochemistry (Trace, Ree and Pge of Pedda Cherlo Palle Gabbro-Diorite Pluton, Prakasam Igneous Province, Andhra Pradesh, India

    Directory of Open Access Journals (Sweden)

    Subramanyam K.S.V.

    2015-09-01

    Full Text Available Prakasam Igneous Province (PIP is an important geological domain in the Eastern Dharwar Craton (EDC, found in the junction zone between the EDC and Eastern Ghat Mobile Belt (EGMB. The Pedda Cherlo Palle (PCP gabbros are massive, leucocratic-mesocractic, and show cumulus textures with minerals plagioclase, cpx, and amphiboles. Compositionally, plagioclase is a labradorite-bytownite, cpx is diopside to augite, olivines are hyalosiderites and amphiboles are magnesiohornblendes. PCP gabbros have normal SiO2, high Al2O3, moderate to high TiO2, Na2O and medium Fe2O3, so, classified as subalkaline tholeiitic gabbros. Fractionated rare earth element (REE patterns, high abundance of large ion lithofile elements (LILE and transitional metals coupled with light REE (LREE relative enrichment over heavy REE (HREE and Nb are characteristics of partial melting of depleted mantle and melts that have undergone fractional crystalisation. These partial melts are enriched in LREE and LILE, due to the addition of slab derived sediment and fluids. PCP gabbros contain low abundance (5.1 to 24.6 ng/g of platinum group elements (PGE, and show an increase in the order Ir>Os>Pt>Ru»Pd>Rh. We propose that the subduction related intraoceanic island arc might have accreted to the southeastern margin of India to the east of Cuddapah basin in a collisional regime that took place during Ur to Rodinia amalgamations.

  11. Separation and purification of four oligostilbenes from Iris lactea Pall. var. chinensis (Fisch.) Koidz by high-speed counter-current chromatography.

    Science.gov (United States)

    Lv, Huanhuan; Wang, Honglun; He, Yanfeng; Ding, Chenxu; Wang, Xiaoyan; Suo, Yourui

    2015-04-15

    A method of using high-speed counter-current chromatography (HSCCC) for preparative isolation and purification of oligostilbenes from the ethanol extracts of seed kernel of Iris lactea Pall. var. chinensis (Fisch.) Koidz was established in this study. Four oligostilbenes were successfully separated and purified by HSCCC with two sets of two-phase solvent system, n-hexane-ethyl acetate-methanol-water (3:6:4.2:5.5, v/v/v/v) in the head-to-tail elution mode for the first separation to mainly isolate vitisin A (58 mg), ɛ-viniferin (76 mg) and peak II (43 mg) from 300 mg of the crude ethanol extracts, and then light petroleum-ethyl acetate-methanol-water (5:5:3:6, v/v/v/v) in the tail-to-head elution mode for the second separation to isolate vitisin B (52 mg) and vitisin C (11 mg) from 100mg of peak II. The purities of the isolated four oligostilbenes were all over 95.0% as determined by HPLC. Vitisin A, vitisin B and vitisin C, resveratrol tetramers, were isolated from Iris lactea for the first time. The preparation of crude sample was simple and the HSCCC method for the isolation and purification of four oligostilbenes was rapid, efficient and economical. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Characteristics and potential values of bio-oil, syngas and biochar derived from Salsola collina Pall. in a fixed bed slow pyrolysis system.

    Science.gov (United States)

    Yue, Yan; Lin, Qimei; Irfan, Muhammad; Chen, Qun; Zhao, Xiaorong

    2016-11-01

    Salsola collina Pall. as a typical euhalophyte was slowly pyrolyzed at 300°C, 500°C and 700°C in a fixed-bed system. The physiochemical properties of syngas, bio-oil and biochar were assayed to understand the impact of pyrolysis temperature on these parameters and then to evaluate their potential values. The results showed that syngas yield (26.07-46.37%) increased with pyrolysis temperature, while biochar yield (47.54-26.83%) decreased. Bio-oil yield (26-30%) was hardly affected by pyrolysis temperature. Both syngas and bio-oil had poor values as direct fuel. The euhalophyte-derived biochar had higher aromaticity (H/C 0.16-0.85, O/C 0.06-0.26), higher cation exchange capacity (198.82-435.74cmolkg(-1)), and higher K(+) (59.35-80.42gkg(-1)) and Na(+) (37.56-53.26gkg(-1)) compared with glycophyte-derived biochars. Our findings imply that halophyte biochar may be more suitable to use as a soil conditioner, which is worthy of further study. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway

    Directory of Open Access Journals (Sweden)

    Ma X

    2015-09-01

    Full Text Available Xiao Ma,1,2 Yan-ling Zhao,2 Yun Zhu,3 Zhe Chen,1,2 Jia-bo Wang,4 Rui-yu Li,1,4 Chang Chen,1,2 Shi-zhang Wei,1,2 Jian-yu Li,3 Bing Liu,5 Rui-lin Wang,3 Yong-gang Li,3 Li-fu Wang,3 Xiao-he Xiao4 1Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Pharmacy, 302 Military Hospital of People’s Liberation Army, Beijing, People’s Republic of China; 3Department of Integrative Medical Center, 302 Military Hospital of People’s Liberation Army, Beijing, People’s Republic of China; 4China Military Institute of Chinese Medicine, 302 Military Hospital of People’s Liberation Army, Beijing, People’s Republic of China; 5School of Chinese Medicine, The University of Hong Kong, Hong Kong Background: Paeonia lactiflora Pall. (PLP, a traditional Chinese herbal medicine, has been used for hepatic disease treatment over thousands of years. In our previous study, PLP was shown to demonstrate therapeutic effect on hepatitis with severe cholestasis. The aim of this study was to evaluate the antioxidative effect of PLP on alpha-naphthylisothiocyanate (ANIT-induced cholestasis by activating NF-E2-related factor 2 (Nrf2 via phosphatidylinositol 3-kinase (PI3K/Akt signaling pathway. Materials and methods: Liquid chromatography-mass spectrometry (LC-MS was performed to identify the main compounds present in PLP. The mechanism of action of PLP and its therapeutic effect on cholestasis, induced by ANIT, were further investigated. Serum indices such as total bilirubin (TBIL, direct bilirubin (DBIL, aspartate aminotransferase (AST, alanine aminotransferase (ALT, alkaline phosphatase (ALP, γ-glutamyl transpeptidase (γ-GT, and total bile acid (TBA were measured, and histopathology of liver was also performed to determine the efficacy of treatment with PLP. Moreover, in order to illustrate the underlying signaling pathway, liver glutathione (GSH content and mRNA or protein levels of glutamate

  14. Digital Gene Expression Analysis to Screen Disease Resistance-Relevant Genes from Leaves of Herbaceous Peony (Paeonia lactiflora Pall.) Infected by Botrytis cinerea.

    Science.gov (United States)

    Gong, Saijie; Hao, Zhaojun; Meng, Jiasong; Liu, Ding; Wei, Mengran; Tao, Jun

    2015-01-01

    Herbaceous peony (Paeonia lactiflora Pall.) is a well-known traditional flower in China and is widely used for landscaping and garden greening due to its high ornamental value. However, disease spots usually appear after the flowering of the plant and may result in the withering of the plant in severe cases. This study examined the disease incidence in an herbaceous peony field in the Yangzhou region, Jiangsu Province. Based on morphological characteristics and molecular data, the disease in this area was identified as a gray mold caused by Botrytis cinerea. Based on previously obtained transcriptome data, eight libraries generated from two herbaceous peony cultivars 'Zifengyu' and 'Dafugui' with different susceptibilities to the disease were then analyzed using digital gene expression profiling (DGE). Thousands of differentially expressed genes (DEGs) were screened by comparing the eight samples, and these genes were annotated using the Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) database. The pathways related to plant-pathogen interaction, secondary metabolism synthesis and antioxidant system were concentrated, and 51, 76, and 13 disease resistance-relevant candidate genes were identified, respectively. The expression patterns of these candidate genes differed between the two cultivars: their expression of the disease-resistant cultivar 'Zifengyu' sharply increased during the early stages of infection, while it was relatively subdued in the disease-sensitive cultivar 'Dafugui'. A selection of ten candidate genes was evaluated by quantitative real-time PCR (qRT-PCR) to validate the DGE data. These results revealed the transcriptional changes that took place during the interaction of herbaceous peony with B. cinerea, providing insight into the molecular mechanisms of host resistance to gray mold.

  15. Digital Gene Expression Analysis to Screen Disease Resistance-Relevant Genes from Leaves of Herbaceous Peony (Paeonia lactiflora Pall. Infected by Botrytis cinerea.

    Directory of Open Access Journals (Sweden)

    Saijie Gong

    Full Text Available Herbaceous peony (Paeonia lactiflora Pall. is a well-known traditional flower in China and is widely used for landscaping and garden greening due to its high ornamental value. However, disease spots usually appear after the flowering of the plant and may result in the withering of the plant in severe cases. This study examined the disease incidence in an herbaceous peony field in the Yangzhou region, Jiangsu Province. Based on morphological characteristics and molecular data, the disease in this area was identified as a gray mold caused by Botrytis cinerea. Based on previously obtained transcriptome data, eight libraries generated from two herbaceous peony cultivars 'Zifengyu' and 'Dafugui' with different susceptibilities to the disease were then analyzed using digital gene expression profiling (DGE. Thousands of differentially expressed genes (DEGs were screened by comparing the eight samples, and these genes were annotated using the Gene ontology (GO and Kyoto encyclopedia of genes and genomes (KEGG database. The pathways related to plant-pathogen interaction, secondary metabolism synthesis and antioxidant system were concentrated, and 51, 76, and 13 disease resistance-relevant candidate genes were identified, respectively. The expression patterns of these candidate genes differed between the two cultivars: their expression of the disease-resistant cultivar 'Zifengyu' sharply increased during the early stages of infection, while it was relatively subdued in the disease-sensitive cultivar 'Dafugui'. A selection of ten candidate genes was evaluated by quantitative real-time PCR (qRT-PCR to validate the DGE data. These results revealed the transcriptional changes that took place during the interaction of herbaceous peony with B. cinerea, providing insight into the molecular mechanisms of host resistance to gray mold.

  16. Smart Device-Supported BDS/GNSS Real-Time Kinematic Positioning for Sub-Meter-Level Accuracy in Urban Location-Based Services.

    Science.gov (United States)

    Wang, Liang; Li, Zishen; Zhao, Jiaojiao; Zhou, Kai; Wang, Zhiyu; Yuan, Hong

    2016-12-21

    Using mobile smart devices to provide urban location-based services (LBS) with sub-meter-level accuracy (around 0.5 m) is a major application field for future global navigation satellite system (GNSS) development. Real-time kinematic (RTK) positioning, which is a widely used GNSS-based positioning approach, can improve the accuracy from about 10-20 m (achieved by the standard positioning services) to about 3-5 cm based on the geodetic receivers. In using the smart devices to achieve positioning with sub-meter-level accuracy, a feasible solution of combining the low-cost GNSS module and the smart device is proposed in this work and a user-side GNSS RTK positioning software was developed from scratch based on the Android platform. Its real-time positioning performance was validated by BeiDou Navigation Satellite System/Global Positioning System (BDS/GPS) combined RTK positioning under the conditions of a static and kinematic (the velocity of the rover was 50-80 km/h) mode in a real urban environment with a SAMSUNG Galaxy A7 smartphone. The results show that the fixed-rates of ambiguity resolution (the proportion of epochs of ambiguities fixed) for BDS/GPS combined RTK in the static and kinematic tests were about 97% and 90%, respectively, and the average positioning accuracies (RMS) were better than 0.15 m (horizontal) and 0.25 m (vertical) for the static test, and 0.30 m (horizontal) and 0.45 m (vertical) for the kinematic test.

  17. Smart Device-Supported BDS/GNSS Real-Time Kinematic Positioning for Sub-Meter-Level Accuracy in Urban Location-Based Services

    Directory of Open Access Journals (Sweden)

    Liang Wang

    2016-12-01

    Full Text Available Using mobile smart devices to provide urban location-based services (LBS with sub-meter-level accuracy (around 0.5 m is a major application field for future global navigation satellite system (GNSS development. Real-time kinematic (RTK positioning, which is a widely used GNSS-based positioning approach, can improve the accuracy from about 10–20 m (achieved by the standard positioning services to about 3–5 cm based on the geodetic receivers. In using the smart devices to achieve positioning with sub-meter-level accuracy, a feasible solution of combining the low-cost GNSS module and the smart device is proposed in this work and a user-side GNSS RTK positioning software was developed from scratch based on the Android platform. Its real-time positioning performance was validated by BeiDou Navigation Satellite System/Global Positioning System (BDS/GPS combined RTK positioning under the conditions of a static and kinematic (the velocity of the rover was 50–80 km/h mode in a real urban environment with a SAMSUNG Galaxy A7 smartphone. The results show that the fixed-rates of ambiguity resolution (the proportion of epochs of ambiguities fixed for BDS/GPS combined RTK in the static and kinematic tests were about 97% and 90%, respectively, and the average positioning accuracies (RMS were better than 0.15 m (horizontal and 0.25 m (vertical for the static test, and 0.30 m (horizontal and 0.45 m (vertical for the kinematic test.

  18. A New Real-Time Cycle Slip Detection and Repair Method under High Ionospheric Activity for a Triple-Frequency GPS/BDS Receiver

    Directory of Open Access Journals (Sweden)

    Wanke Liu

    2018-02-01

    Full Text Available Cycle slip detection and repair is a prerequisite for high-precision global navigation satellite system (GNSS-based positioning. With the modernization and development of GNSS systems, more satellites are available to transmit triple-frequency signals, which allows the introduction of additional linear combinations and provides new opportunities for cycle slip detection and repair. In this paper, we present a new real-time cycle slip detection and repair method under high ionospheric activity for undifferenced Global Positioning System (GPS/BeiDou Navigation Satellite System (BDS triple-frequency observations collected with a single receiver. First, three optimal linearly independent geometry-free pseudorange minus phase combinations are selected to correctly and uniquely determine the cycle slips on the original triple-frequency carrier phase observations. Then, a second-order time-difference algorithm is employed for the pseudorange minus phase combinations to mitigate the impact of between-epoch ionospheric residuals on cycle slip detection, which is especially beneficial under high ionospheric activity. The performance of the approach is verified with static GPS/BDS triple-frequency observations that are collected with a 30 s sampling interval under active ionospheric conditions, and observations are manually inserted with simulated cycle slips. The results show that the method can correctly detect and repair cycle slips at a resolution as small as 1 cycle. Moreover, kinematic data collected from car-driven and airborne experiments are also processed to verify the performance of the method. The experimental results also demonstrate that the method is effective in processing kinematic data.

  19. A New Real-Time Cycle Slip Detection and Repair Method under High Ionospheric Activity for a Triple-Frequency GPS/BDS Receiver.

    Science.gov (United States)

    Liu, Wanke; Jin, Xueyuan; Wu, Mingkui; Hu, Jie; Wu, Yun

    2018-02-01

    Cycle slip detection and repair is a prerequisite for high-precision global navigation satellite system (GNSS)-based positioning. With the modernization and development of GNSS systems, more satellites are available to transmit triple-frequency signals, which allows the introduction of additional linear combinations and provides new opportunities for cycle slip detection and repair. In this paper, we present a new real-time cycle slip detection and repair method under high ionospheric activity for undifferenced Global Positioning System (GPS)/BeiDou Navigation Satellite System (BDS) triple-frequency observations collected with a single receiver. First, three optimal linearly independent geometry-free pseudorange minus phase combinations are selected to correctly and uniquely determine the cycle slips on the original triple-frequency carrier phase observations. Then, a second-order time-difference algorithm is employed for the pseudorange minus phase combinations to mitigate the impact of between-epoch ionospheric residuals on cycle slip detection, which is especially beneficial under high ionospheric activity. The performance of the approach is verified with static GPS/BDS triple-frequency observations that are collected with a 30 s sampling interval under active ionospheric conditions, and observations are manually inserted with simulated cycle slips. The results show that the method can correctly detect and repair cycle slips at a resolution as small as 1 cycle. Moreover, kinematic data collected from car-driven and airborne experiments are also processed to verify the performance of the method. The experimental results also demonstrate that the method is effective in processing kinematic data.

  20. Triple-Frequency Code-Phase Combination Determination: A Comparison with the Hatch-Melbourne-Wübbena Combination Using BDS Signals

    Directory of Open Access Journals (Sweden)

    Chenlong Deng

    2018-02-01

    Full Text Available Considering the influence of the ionosphere, troposphere, and other systematic errors on double-differenced ambiguity resolution (AR, we present an optimal triple-frequency code-phase combination determination method driven by both the model and the real data. The new method makes full use of triple-frequency code measurements (especially the low-noise of the code on the B3 signal to minimize the total noise level and achieve the largest AR success rate (model-driven under different ionosphere residual situations (data-driven, thus speeding up the AR by directly rounding. With the triple-frequency Beidou Navigation Satellite System (BDS data collected at five stations from a continuously-operating reference station network in Guangdong Province of China, different testing scenarios are defined (a medium baseline, whose distance is between 20 km and 50 km; a medium-long baseline, whose distance is between 50 km and 100 km; and a long baseline, whose distance is larger than 100 km. The efficiency of the optimal code-phase combination on the AR success rate was compared with that of the geometry-free and ionosphere-free (GIF combination and the Hatch-Melbourne-Wübbena (HMW combination. Results show that the optimal combinations can always achieve better results than the HMW combination with B2 and B3 signals, especially when the satellite elevation angle is larger than 45°. For the wide-lane AR which aims to obtain decimeter-level kinematic positioning service, the standard deviation (STD of ambiguity residuals for the suboptimal combination are only about 0.2 cycles, and the AR success rate by directly rounding can be up to 99%. Compared with the HMW combinations using B1 and B2 signals and using B1 and B3 signals, the suboptimal combination achieves the best results in all baselines, with an overall improvement of about 40% and 20%, respectively. Additionally, the STD difference between the optimal and the GIF code-phase combinations decreases

  1. A Geometry-Based Cycle Slip Detection and Repair Method with Time-Differenced Carrier Phase (TDCP for a Single Frequency Global Position System (GPS + BeiDou Navigation Satellite System (BDS Receiver

    Directory of Open Access Journals (Sweden)

    Chuang Qian

    2016-12-01

    Full Text Available As the field of high-precision applications based on carriers continues to expand, the development of low-cost, small, modular receivers and their application in diverse scenarios and situations with complex data quality has increased the requirements of carrier-phase data preprocessing. A new geometry-based cycle slip detection and repair method based on Global Position System (GPS + BeiDou Navigation Satellite System (BDS is proposed. The method uses a Time-differenced Carrier Phase (TDCP model, which eliminates the Inner-System Bias (ISB between GPS and BDS, and it is conducive to the effective combination of GPS and BDS. It avoids the interference of the noise of the pseudo-range with cycle slip detection, while the cycle slips are preserved as integers. This method does not limit the receiver frequency number, and it is applicable to single-frequency data. The process is divided into two steps to detect and repair cycle slip. The first step is cycle slip detection, using the Improved Local Analysis Method (ILAM to find satellites that have cycle slips; The second step is to repair the cycle slips, including estimating the float solution of changes in ambiguities at the satellites that have cycle slips with the least squares method and the integer solution of the cycle slips by rounding. In the process of rounding, in addition to the success probability, a decimal test is carried out to validate the result. Finally, experiments with filed test data are carried out to prove the effectiveness of this method. The results show that the detectable cycle slips number with GPS + BDS is much greater than that with GPS. The method can also detect the non-integer outliers while fixing the cycle slip. The maximum decimal bias in repair is less than that with GPS. It implies that this method takes full advantages of multi-system.

  2. A Geometry-Based Cycle Slip Detection and Repair Method with Time-Differenced Carrier Phase (TDCP) for a Single Frequency Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) Receiver.

    Science.gov (United States)

    Qian, Chuang; Liu, Hui; Zhang, Ming; Shu, Bao; Xu, Longwei; Zhang, Rufei

    2016-12-05

    As the field of high-precision applications based on carriers continues to expand, the development of low-cost, small, modular receivers and their application in diverse scenarios and situations with complex data quality has increased the requirements of carrier-phase data preprocessing. A new geometry-based cycle slip detection and repair method based on Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) is proposed. The method uses a Time-differenced Carrier Phase (TDCP) model, which eliminates the Inner-System Bias (ISB) between GPS and BDS, and it is conducive to the effective combination of GPS and BDS. It avoids the interference of the noise of the pseudo-range with cycle slip detection, while the cycle slips are preserved as integers. This method does not limit the receiver frequency number, and it is applicable to single-frequency data. The process is divided into two steps to detect and repair cycle slip. The first step is cycle slip detection, using the Improved Local Analysis Method (ILAM) to find satellites that have cycle slips; The second step is to repair the cycle slips, including estimating the float solution of changes in ambiguities at the satellites that have cycle slips with the least squares method and the integer solution of the cycle slips by rounding. In the process of rounding, in addition to the success probability, a decimal test is carried out to validate the result. Finally, experiments with filed test data are carried out to prove the effectiveness of this method. The results show that the detectable cycle slips number with GPS + BDS is much greater than that with GPS. The method can also detect the non-integer outliers while fixing the cycle slip. The maximum decimal bias in repair is less than that with GPS. It implies that this method takes full advantages of multi-system.

  3. A Geometry-Based Cycle Slip Detection and Repair Method with Time-Differenced Carrier Phase (TDCP) for a Single Frequency Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) Receiver

    OpenAIRE

    Qian, Chuang; Liu, Hui; Zhang, Ming; Shu, Bao; Xu, Longwei; Zhang, Rufei

    2016-01-01

    As the field of high-precision applications based on carriers continues to expand, the development of low-cost, small, modular receivers and their application in diverse scenarios and situations with complex data quality has increased the requirements of carrier-phase data preprocessing. A new geometry-based cycle slip detection and repair method based on Global Position System (GPS) + BeiDou Navigation Satellite System (BDS) is proposed. The method uses a Time-differenced Carrier Phase (TDCP...

  4. 白血球除去フィルター(Sepacell R-500 A/Pall PL 50/100)使用による抗血小板抗体産生に及ぼす効果

    OpenAIRE

    下山, 丈人; 藤村, 吉博; 河本, 順雄; 西田, 幸世; 吉田, 英里; 水本, 保子; 八木, 秀男; 松本, 雅則; 山中, 貴世; 森井, 武志; 西川, 潔; 成田, 亘啓

    1992-01-01

    To minimize various post-transfusion complications caused by white blood cell components, Sepacell R-500 A filters (Asahi Medical) for red blood cell products and PL 50/100 filters (Pall) for platelet products to remove white blood cells were clinicallyused in a total of 46 patients with leukemia and its allied disorders, and the results were compared with those of 19 patients with whom the filters were not used. Platelet allo-antibodies, assayed by mixed passive haemagglutination (MPHA) meth...

  5. BDS thin film damage competition

    Energy Technology Data Exchange (ETDEWEB)

    Stolz, C J; Thomas, M D; Griffin, A J

    2008-10-24

    A laser damage competition was held at the 2008 Boulder Damage Symposium in order to determine the current status of thin film laser resistance within the private, academic, and government sectors. This damage competition allows a direct comparison of the current state-of-the-art of high laser resistance coatings since they are all tested using the same damage test setup and the same protocol. A normal incidence high reflector multilayer coating was selected at a wavelength of 1064 nm. The substrates were provided by the submitters. A double blind test assured sample and submitter anonymity so only a summary of the results are presented here. In addition to the laser resistance results, details of deposition processes, coating materials, and layer count will also be shared.

  6. Multi-GNSS real-time precise positioning service and Initial assessment of BDS-3 (G Division Outstanding ECS Award Lecture)

    Science.gov (United States)

    Li, Xingxing; Ge, Maaorong; Li, Xin; Zhang, Xiuaohong; Wu, Mingkui; Wickert, Jens; Schuh, Harald

    2017-04-01

    The rapid development of multi-constellation GNSSs (Global Navigation Satellite Systems, e.g., BeiDou, Galileo, GLONASS, GPS) and the IGS (International GNSS Service) Multi-GNSS Experiment (MGEX) bring great opportunities and challenges for real-time precise positioning service. In this contribution, we present a GPS+GLONASS+BeiDou+Galileo four-system model to fully exploit the observations of all these four navigation satellite systems for real-time precise orbit determination, clock estimation and positioning. Meanwhile, an efficient multi-GNSS real-time precise positioning service system is designed and demonstrated by using the Multi-GNSS Experiment (MGEX) and International GNSS Service (IGS) data streams including stations all over the world. The addition of the BeiDou, Galileo and GLONASS systems to the standard GPS-only processing, reduces the convergence time almost by 70%, while the positioning accuracy is improved by about 25%. The successful launch of five new-generation satellites of the Chinese BeiDou Navigation Satellite System (BDS-3) marks a significant step in expanding BeiDou into a navigation system with global coverage. We present an initial characterization and performance assessment for these new-generation BeiDou-3 satellites and their signals. The characteristics of the B1C, B1I, B2a, B2b and B3I signals are evaluated in terms of observed carrier-to-noise density ratio, pseudorange multipath and noise, triple-frequency carrier phase ionosphere-free and geometry-free combination, and double-differenced carrier phase and code residuals. With respect to BeiDou-2 satellites, the analysis of code multipath shows that the elevation-dependent code biases, which have been previously identified to exist in the code observations of BeiDou-2 satellites, seem to be not obvious for all the available signals of new-generation BeiDou-3 satellites. This will significantly benefit precise applications that resolve wide-lane ambiguity based on Melbourne

  7. Palle Qvist's Blog about Digital Teaching

    DEFF Research Database (Denmark)

    Qvist, Palle

    2010-01-01

    Blog created to support the first pedagogical day about e-learning arranged by the official AAU – “Pedagogical open day in Aalborg 17th of March 2010″. New articles added continuosly......Blog created to support the first pedagogical day about e-learning arranged by the official AAU – “Pedagogical open day in Aalborg 17th of March 2010″. New articles added continuosly...

  8. Haridusvabadus / ajakirjast "The Freeman" tlk. Riinu Pall

    Index Scriptorium Estoniae

    2000-01-01

    Praegune haridussüsteem on vastuolus individuaalse vabaduse ja vastutuse põhimõtetega vabas ühiskonnas, hariduse kvaliteedi tõstmise asemel on süsteemis madal tase ja ebatõhus vahendite kasutamine

  9. Total Glucosides of Paeonia lactiflora Pall Suppress Nitric Oxide ...

    African Journals Online (AJOL)

    regulated by NO [14]. At the same time, cytokines, intercellular adhesion molecules, vascular cell adhesion molecules and matrix metalloproteinases, which accelerate the development of inflammation and tissue damage,. Fig 3: Effect of TGPL on DNA binding activity of NF-. κB in LPS-stimulated RAW264.7 cells. RAW264.7.

  10. Accountability and transparency of financial sector supervision / Pall Gunnar Palsson

    Index Scriptorium Estoniae

    Palsson, Pall Gunnar

    2001-01-01

    Finantsjärelvalve üheks oluliseks tingimuseks on läbipaistvus. Rahvusvahelise Valuutafondi poolt vastu võetud raha- ja rahanduspoliitika heade tavade koodeksist. Ülevaade Islandi finantsinspektsiooni töökorraldusest

  11. Sotsiaaluuringud aitavad juhtida perepoliitikat / Kati Karelson, Katre Pall

    Index Scriptorium Estoniae

    Karelson, Kati

    2003-01-01

    Riiklikust perepoliitikast, selle tulemuste analüüs ja võrdlus teistes Euroopa riikides rakendatud institutsionaalsete meetmetega. Artikkel põhineb Euroopa Komisjoni 5. raamprogrammi projektina rahastatud ja aastail 2000-2003 korraldatud uuringu IPROSEC tulemustel. Skeemid. Tabel

  12. Design and Implementation of BDS RTCM SSR Message

    Science.gov (United States)

    Xiao, Xia; Cheng, Fang; Liu, Feng; Lu, XiaoChun

    2017-09-01

    Based on the real-time differential positioning system of Beidou wide area, a set of Beidou high-precision differential information transmission protocol is studied and designed. After the system generates satellite precise orbit and clock difference products, it needs to be sent to the users in a certain data format through C band GEO communication satellite. The transport protocol should be designed according to the data volume and update rate of the system. At the same time, it is necessary to combine the signal system, satellite resources and the restriction and restriction of the receiver implementation technology. It refers to the relevant fields and international similar systems of technology and standards to design. This paper establishes a set of technical indicators which can measure the pros and cons of differential message organization and broadcasting strategy. Through modeling, simulation and actual test, this paper makes a comprehensive comparison of different strategies. Finally, a transmission protocol design scheme which has good performance and meets the system service requirements is presented.

  13. Summary of the BDS and MDI CLIC08 Working Group

    CERN Document Server

    Tomás, R; Ahmed, I; Ambatu, PK; Angal-Kalinin, D; Barlow, R; Baud, J P; Bolzon, B; Braun, H; Burkhardt, H; Burt, GC; Corsini, R; Dalena, B; Dexter, AC; Dolgashev, V; Elsener, K; Fernandez Hernando, JL; Gaillard, G; Geffroy, N; Jackson, F; Jeremie, A; Jones, RM; McIntosh, P; Moffeit, K; Peltier, F; Resta-López, J; Rumolo, G; Schulte, D; Seryi, A; Toader, A; Zimmermann, F

    2008-01-01

    This note summarizes the presentations held within the Beam Delivery System and Machine Detector Interface working group of the CLIC08 workshop. The written contributions have been provided by the presenters on a voluntary basis.

  14. Maxillofacial Surgery, FG Macigo, BDS, MPH, Senior Lecturer

    African Journals Online (AJOL)

    2007-06-01

    Jun 1, 2007 ... leading vehicles primarily responsible for accidents followed by lorries, buses and taxis put together, and passenger service vehicles with a carrying capacity of between 9-30 people (matatus). For example, in. 2002, private salon cars were responsible for 6,931 accidents, lorries, buses and taxis 2,781 and ...

  15. Application of calcium, boron and sucrose on cut peony stems (Paeonia lactiflora Pall. cv. Karl Rosenfield

    Directory of Open Access Journals (Sweden)

    LOYOLA NELSON EDUARDO

    2012-04-01

    Full Text Available

     

    In cut flowers, there must be clear guidelines for export, therefore, it is essential to proper postharvest management, to store the flowers for as long as possible in top condition, both for transit and vase life; in Chile there is very little knowledge about this operation. In order to address these questions, a study was conducted to evaluate the performance of postharvest life of the peony cultivar ‘Karl Rosenfield’, using four treatments: water, preharvest Borocal® with water, Borocal® with 100 g sucrose/L of water, and 100 g sucrose/L of water, some of which had Borocal® added preharvest and sucrose applied postharvest; evaluating four quality parameters in cut flowers: floral diameter, stem curvature, stem weight and vase life. The present study lasted 25 days, which was the total time of refrigerated storage. The results showed that peony stems with preharvest applications of Borocal® and postharvest applications of only water presented the highest values in terms of floral diameter, stem weight and particularly increased vase life, with no significant differences in stem curvature.

  16. Arsenic forms and their combinations induce differences in phenolic accumulation in Ulmus laevis Pall.

    Science.gov (United States)

    Drzewiecka, Kinga; Gąsecka, Monika; Rutkowski, Paweł; Magdziak, Zuzanna; Goliński, Piotr; Mleczek, Mirosław

    2018-01-01

    Total phenolics and the profile of phenolic acids and flavonoids were investigated in the roots and leaves of Ulmus laevis cultured on the medium with inorganic and organic arsenic - As(III), As(V) and DMA(V) at 0.06mM and their equimolar combinations. Further, the accumulation of salicylic acid (free and glucoside-bound) and lipid oxidation were assayed following a three-month long experiment. As treatment caused elevated production of phenolics, which was higher in photosynthetic tissue than in roots for all As forms and their combinations, and their overall content was correlated with the accumulation of organic As in roots and As(III) in leaves. The accumulation of organic As strongly induced shikimate-derived protocatechiuc acid in roots. Contrary to this, shikimate-derived phenolics (protocatechuic, gallic acids and 4-HBA) were suppressed in leaves, while the accumulation of C6C3 acids (caffeic, p-coumaric and chlorogenic) was stimulated by As(V) application. Surprisingly, these acids were not detected in the leaves of As(III)-treated plants, and mutually applied As(III) and DMA(V) reduced their content. DMA(V) negatively influenced the level of salicylic acid and its storage mechanism and this effect correlated with elevated MDA content in leaves. Quercetin accumulation was observed in both organs (mainly leaves) of DMA(V)-treated plants thereby proving its function in defensive response of Ulmus laevis to organic forms of As. Copyright © 2017 Elsevier GmbH. All rights reserved.

  17. Preventing microbial growth on pall-rings when upgrading biogas using absorption with water wash

    Energy Technology Data Exchange (ETDEWEB)

    Haakansson, Anna

    2006-07-15

    For produced biogas to be usable as vehicle fuel it has to be upgraded to a higher energy content. This is accomplished by elevation of the methane concentration through removal of carbon dioxide. Absorption with water wash is the most common upgrading method used in Sweden today. The upgrading technique is based on the fact that carbon dioxide is more soluble in water than methane. Upgrading plants that utilises this method have problems with microbial growth in the system. This growth eventually leads to a stop in operation due to the gradually drop in upgrading capacity. The aim of this thesis were to evaluate the possibility to through some kind of water treatment maintain an acceptable level of growth or altogether prevent it in order to maintain an acceptable process capacity and thereby avoid the need to clean. Through collection of literature the implementation possibilities were evaluated with regard to efficiency, economic sustainability and if there would be a release of any harmful substances. In order to prevent the microbial growth in the columns the treatment should either focus on removing microorganisms or limit the accessible nutrients. For the single pass system it is concluded that the treatment should reduce the biofilm formation and be employed in an intermittent way. Among the evaluated treatments focusing on the reduction of microorganisms the addition of peracetic acid seems to be the most promising one. For the regenerating system the treatment method could focus on either one. As for the single pass system peracetic acid could be added to reduce the amount of microorganism. To reduce the amount of organic matter an advanced oxidation process could be deployed with the advantage that it also could remove the microorganisms.

  18. Phenolic Compounds from Halimodendron halodendron (Pall. Voss and Their Antimicrobial and Antioxidant Activities

    Directory of Open Access Journals (Sweden)

    Jihua Wang

    2012-09-01

    Full Text Available Halimodendron halodendron has been used as forage in northwestern China for a long time. Its young leaves and flowers are edible and favored by indigenous people. In this study, eleven phenolic compounds were bioassay-guided and isolated from the aerial parts of H. halodendron for the first time. They were identified by means of physicochemical and spectrometric analysis as quercetin (1, 3,5,7,8,4'-pentahydroxy-3'-methoxy flavone (2, 3-O-methylquercetin (3, 3,3'-di-O-methylquercetin (4, 3,3'-di-O-methylquercetin-7-O-β-D-glucopyranoside (5, isorhamentin-3-O-β-D-rutinoside (6, 8-O-methylretusin (7, 8-O-methylretusin-7-O-β-D-glucopyranoside (8, salicylic acid (9, p-hydroxybenzoic acid (ferulic acid (10, and 4-hydroxy-3-methoxy cinnamic acid (11. They were sorted as flavonols (1–6, soflavones (7 and 8, and phenolic acids (9–11. Among the compounds, flanools 1–4 revealed a strong antibacterial activity with minimum inhibitory concentration (MIC values of 50–150 μg/mL, and median inhibitory concentration (IC50 values of 26.8–125.1 μg/mL. The two isoflavones (7 and 8 showed moderate inhibitory activity on the test bacteria. Three phenolic acids (9, 10 and 11 showed strong antibacterial activity with IC50 values of 28.1–149.7 μg/mL. Antifungal activities of the compounds were similar to their antibacterial activities. All these phenolic compounds showed significant antimicrobial activity with a broad spectrum as well as antioxidant activity based on 1,1-diphenyl-2-picrylhydrazyl (DPPH radical scavenging and β-carotene-linoleic acid bleaching assays. In general, the flavonol aglycones with relatively low polarity exhibited stronger activities than the glycosides. The results suggest the potential of this plant as a source of functional food ingredients and provide support data for its utilization as forage as well.

  19. Anti-depressant effect of Paeonia lactiflora Pall extract in rats

    African Journals Online (AJOL)

    dose ≥ 150 mg/kg significantly inhibited MAO A activity in rat whole brain in a dose-dependent manner. (p < 0.01); however, only oral administration ... stagnant liver qi and the active principles from some of them were isolated [2,3]. ... The mitochondrial fraction suspended in 10 milliliter of cold sodium phosphate buffer (10 ...

  20. anti Bd,s → D*d,sV and anti B*d,s → Dd,sV decays in QCD factorization and possible puzzles

    International Nuclear Information System (INIS)

    Chang, Qin; Chen, Ling-Xin; Zhang, Yun-Yun; Sun, Jun-Feng; Yang, Yue-Ling

    2016-01-01

    Motivated by the rapid development of heavy-flavor experiments, phenomenological studies of nonleptonic anti B d,s → D * d,s V and anti B * d,s → D d,s V (V = ρ, K*) decays are performed within the framework of QCD factorization. Relative to the previous work, the QCD corrections to the transverse amplitudes are evaluated at next-to-leading order. The theoretical predictions of the observables are updated. For the measured anti B d,s → D * d,s V decays, the tensions between theoretical results and experimental measurements, i.e. the ''R ds V puzzle'' and ''D*V (or R V/l anti ν l ) puzzle'', are presented after detailed analyses. For the anti B * d,s → D d,s V decays, they have relatively large branching fractions of the order >or similar O(10 -9 ) and are in the scope of Belle-II and LHCb experiments. Moreover, they also provide a way to crosscheck the possible puzzles mentioned above through the similar ratios R ds 'V and R ' V/l anti ν l . More refined experimental measurements and theoretical efforts are required to confirm or refute such two anomalies. (orig.)

  1. Transition Practices for Adjudicated Youth with E/BDs and Related Disabilities

    Science.gov (United States)

    Clark, Heather Griller; Unruh, Deanne

    2010-01-01

    Reentry outcomes for formerly incarcerated youth are dismal. The challenges these youth face are even further intensified when they have learning or emotional and behavioral disabilities. Successful transition services need to be initiated in the correctional facility and continue in the community. This article discusses interventions designed to…

  2. Study of Charmless Bd,s0 → h+h'-π0 decays in LHCb

    International Nuclear Information System (INIS)

    Roa Romero, D.A.

    2013-01-01

    This thesis work is about the identification of charmless three-body decays of neutral B mesons with a π 0 in the final state (B d,s 0 → h + h' - π 0 ) through the analysis of a 1.0 fb -1 data sample collected in 2011 by the LHCb experiment at the LHC. Those modes are sensitive to CKM parameters and allow to test Standard Model predictions related to CP violation. Some of them, such as B s 0 → K - π + π 0 and B s 0 → K + K - π 0 , have not been observed previously. This is the first analysis with energetic π 0 in LHCb. To evaluate the detector performance for π 0 , D *+ → D 0 (→ K - π + π 0 )π + decays have been selected. This provides a clean and high statistics sample of neutral pions used to study their energy calibration as well as the effectiveness of the π 0 /γ separation tool of the experiment. Radiative decays are indeed the most dangerous backgrounds for the study of B d,s 0 → h + h' - π 0 modes. To select B d,s 0 → h + h' - π 0 events, a dedicated trigger algorithm has been implemented. It complements the standard online selections and significantly improves the efficiency. Offline, obvious backgrounds, mainly from charm decays, are rejected applying simple criteria. The sample is then further purified using a multivariate classifier. At last, information from the ring imaging Cherenkov detectors allows to separate π + π - π 0 , K ± π ± π 0 and K + K - π 0 final states. A simultaneous fit of the reconstructed B mass spectra in the three sub-samples is used to extract the signal yields. It accounts for the different backgrounds remaining as well as for the signal cross-feeds from one sub-sample to the other. The B 0 → π + π - π 0 , B 0 → K + π - π 0 and B s 0 → K + K - π 0 contributions are clearly established. This is the first observation of the B s 0 → K + K - π 0 decay mode. (author)

  3. ADST, Version Description Document for the BDS-D PVD 1.0.0

    Science.gov (United States)

    1993-04-02

    common/libsrc/libmatrix/RCS/libmatrix.h,v Working file: libmatrix.h head: 1.1 description: Initial PVD Turnover * 71 U ADSL /WDLUTR--93-003076 April 2...003076 April 2, 1993 di: 1992/I 1/03 19:23:58; author: cm- adsL - staae: Exp; Initial Version RCS file: Joo",libsf,,Ibev,’CSduoatioac.v Woring rile

  4. ON THE PROBLEM OF SPATIAL DEMOGRAPHIC STRUCTURE AND ONTOGENESIS OF HALOCNEMUM STROBILACEUM [(PALL. BIEB.] IN THE REPUBLIC OF KALMYKIA

    Directory of Open Access Journals (Sweden)

    V. G. Lazareva

    2016-01-01

    Full Text Available The aim of research is to study coenopopulations of Halocnemum strobilaceum on soft salt marshes of the lake "Cagan USN" (Yashkul district, Republic of Kalmykia.Materials and methods. The article presents data on the ontogeny, demographic and spatial structure of H. strobilaceum for practical and theoretical use due to the degradation of pastures and secondary salinity in the water reclamation. Research on coenopopulations of Halocnemum has been carried out according to the methods of studying spatial and demographic structure of the plant phytocenoses (1950, plant collection and herbarization (1977, and making sites of 3x3 meters.Results. Research has allowed us to identify 6 age phases of H. strobilaceum: p, im, v, g1, g2-g3, svg, s, and the ontogenetic state: p - 5%, im - 5%, v - 5%, g1 - 35 %, g2-g3 - 35%, svg - 5%, s - 10%. During the research of coenopopulations of Halocnemum strobilaceum we have revealed the polyvariance ontomorphogenesis phenomenon, which is manifested in the transition of individuals from senile (s age condition, in particular, to senile-virginal-generative (svg. In addition, at this stage, we have observed new shoots, habitually similar to vegetative, able to bloom the following year (the state svg. The analysis of ontogenesis of individuals of Halocnemum strobilaceum has showed the predominance of young (g1 and middle-aged (g2-g3 generative phase.Conclusion. Thus, a temporary rejuvenation of Halocnemum strobilaceum communities at the lake of "Cagan USN" is considered by us as the occurrence of certain adaptations to the effects of different natural and anthropogenic factors. This ability of Halocnemum strobilaceum to quickly restore spatial demographic structure of its coenopopulations indicates the high ecological and biological potential of this kind of dominant on the soft salt marshes.

  5. Palynomorphological features of Suaeda acuminata (C.A. Mey. Moq., Suaeda prostrata Pall. and Tamarix ramosissima Ledeb.

    Directory of Open Access Journals (Sweden)

    Tatyana I. Tsymbalyuk

    2012-03-01

    Full Text Available The pollen morphology of Suaeda acuminata , S. prostratа and Tamarix ramosissima from Ukrainian flora has been studied with light and scanning electron microscopy. The main morphological features of pollen grains of three taxa, which spread within halophytes vegetation, are determined. The results has considered as potential useful for identification of the fossil pollen under paleopalynological or paleoecological study.

  6. [Cytological State of Gonads and Level of Thyroid and Sex Steroid Hormones in Black Sea Trout Salmo trutta labrax Pall].

    Science.gov (United States)

    Pavlov, E D; Ganzha, E V; Kostin, V V; Pavlov, D S

    2015-01-01

    Cytological state of the gonads and hormonal state of hatchery Black Sea trout before differentiation into resident and anadromous forms (parr) at an age of 15 months have been examined. It has been shown that the hormonal changes associated with the choice of life strategy in the Black Sea trout females and males are pronounced to different degrees. As compared with the resident and anadromous individuals; the female parr display a low rate of oogenesis and similar hormonal status, while characteristic of the male parr are an intermediate rate of spermatogenesis, a low level of thyroid hormones and estradiol, and a medium testosterone level. As has been found, the undifferentiated Black Sea trout individuals predominantly develop into the resident form.

  7. Effect of Calcium Sprays on Mechanical Strength and Cell Wall Fractions of Herbaceous Peony (Paeonia Lactiflora Pall. Inflorescence Stems

    Directory of Open Access Journals (Sweden)

    Jintao Ge

    2012-04-01

    Full Text Available Calcium is an essential element and imparts significant structural rigidity to the plant cell walls, which provide the main mechanical support to the entire plant. In order to increase the mechanical strength of the inflorescence stems of herbaceous peony, the stems are treated with calcium chloride. The results shows that preharvest sprays with 4% (w/v calcium chloride three times after bud emergence are the best at strengthening “Da Fugui” peonies’ stems. Calcium sprays increased the concentrations of endogenous calcium, total pectin content as well as cell wall fractions in herbaceous peonies stems, and significantly increased the contents of them in the top segment. Correlation analysis showed that the breaking force of the top segment of peonies’ stems was positively correlated with the ratio of water insoluble pectin to water soluble pectin (R = 0.673 as well as lignin contents (R = 0.926 after calcium applications.

  8. Species diversity, vegetation pattern and conservation of Gentiana macrophylla Pall. communities in Dongling mountain meadow, Beijing, China

    International Nuclear Information System (INIS)

    Sadia, S.; Zhang, J.T.; Bai, X.; Shedayi, A.A.; Tariq, A.

    2017-01-01

    Gentiana macrophylla, native to mountainous areas of Central and Southern Asia, is most popular remedy for rheumatism and pains in Traditional Chinese Medicine with an extensive demand in local market. Our study aimed to classify G. macrophylla communities and to find out the impact of topographic and soil factors on their diversity and distribution in Dongling mountain meadow, Beijing, China. Seventy five samples in 15 transects separated by 50m distance in altitude along an elevation gradient (1592-2298m) were established by quadrate method. TWINSAPN and CCA were used for classification and ordination, respectively. Six diversity indices (Species richness, Shannon-Weiner heterogeneity, Simpson’s index, Hill’s index, Pielou evenness and McIntosh evenness) were used to analyze the pattern of species diversity and polynomial regression analysis was used to establish their relationship with environmental variables. TWINSPAN classified G. macrophylla communities into 8 types and CCA indicated that soil pH, soil temperature, soil type, disturbance, total N, total K, Mg and Zn were significantly related to these communities. Elevation was the most significant factor that affecting the diversity and distribution of G. macrophylla communities. Significant effect of environment, topography and disturbance to meadow communities of G. macrophylla highly suggests some important measures such as uprooting restriction, tourism limitation in meadow area, monitoring of functional diversity, fertilization, irrigation, cloning and cultivation to protect and conserve it and its communities to be used in medicine industry. (author)

  9. [Identification of European (Capreolus capreolus L.) and Siberian (C. pygargus Pall.) roe deer hybrids by microsatellite marker analysis].

    Science.gov (United States)

    Plakhina, D A; Zvychanaya, E Yu; Kholodova, M V; Danilkin, A A

    2014-07-01

    An analysis of 130 tissue specimens of the European (Capreolus capreolus) and the Siberian (C. pygargus) roe deer from nine regions of Russia and Ukraine using microsatellite loci analysis was conducted, aimed at the identification of hybrid animals. An optimized complex of 21 microsatellite loci was selected for the determination of species specificity and the search for interspecies hybrids. Hybrid animals were revealed in the Moscow and Volgograd regions. Their ratio in the total sample obtained in the European part of Russia was 11.9%.

  10. A Lane-Level LBS System for Vehicle Network with High-Precision BDS/GPS Positioning

    Science.gov (United States)

    Guo, Chi; Guo, Wenfei; Cao, Guangyi; Dong, Hongbo

    2015-01-01

    In recent years, research on vehicle network location service has begun to focus on its intelligence and precision. The accuracy of space-time information has become a core factor for vehicle network systems in a mobile environment. However, difficulties persist in vehicle satellite positioning since deficiencies in the provision of high-quality space-time references greatly limit the development and application of vehicle networks. In this paper, we propose a high-precision-based vehicle network location service to solve this problem. The major components of this study include the following: (1) application of wide-area precise positioning technology to the vehicle network system. An adaptive correction message broadcast protocol is designed to satisfy the requirements for large-scale target precise positioning in the mobile Internet environment; (2) development of a concurrence service system with a flexible virtual expansion architecture to guarantee reliable data interaction between vehicles and the background; (3) verification of the positioning precision and service quality in the urban environment. Based on this high-precision positioning service platform, a lane-level location service is designed to solve a typical traffic safety problem. PMID:25755665

  11. Asymmetric Dual-Band Tracking Technique for Optimal Joint Processing of BDS B1I and B1C Signals.

    Science.gov (United States)

    Wang, Chuhan; Cui, Xiaowei; Ma, Tianyi; Zhao, Sihao; Lu, Mingquan

    2017-10-16

    Along with the rapid development of the Global Navigation Satellite System (GNSS), satellite navigation signals have become more diversified, complex, and agile in adapting to increasing market demands. Various techniques have been developed for processing multiple navigation signals to achieve better performance in terms of accuracy, sensitivity, and robustness. This paper focuses on a technique for processing two signals with separate but adjacent center frequencies, such as B1I and B1C signals in the BeiDou global system. The two signals may differ in modulation scheme, power, and initial phase relation and can be processed independently by user receivers; however, the propagation delays of the two signals from a satellite are nearly identical as they are modulated on adjacent frequencies, share the same reference clock, and undergo nearly identical propagation paths to the receiver, resulting in strong coherence between the two signals. Joint processing of these signals can achieve optimal measurement performance due to the increased Gabor bandwidth and power. In this paper, we propose a universal scheme of asymmetric dual-band tracking (ASYM-DBT) to take advantage of the strong coherence, the increased Gabor bandwidth, and power of the two signals in achieving much-reduced thermal noise and more accurate ranging results when compared with the traditional single-band algorithm.

  12. VizieR Online Data Catalog: VLM stars and BDs in Upper Sco using Gaia DR1 (Cook+, 2017)

    Science.gov (United States)

    Cook, N. J.; Scholz, A.; Jayawardhana, R.

    2018-04-01

    We used literature samples (Dawson et al. (2011MNRAS.418.1231D, Cat. J/MNRAS/418/1231), Lodieu et al. (2011MNRAS.418.2604L), Dawson et al. (2013MNRAS.429..903D, Cat. J/MNRAS/429/903), Lodieu (2013MNRAS.431.3222L, Cat. J/MNRAS/431/3222), Lodieu (2013MNRAS.435.2474L, Cat. J/MNRAS/435/2474) and Dawson et al. (2014MNRAS.442.1586D)) and UKIDSS photometric data (Lawrence et al. (2007MNRAS.379.1599L, Cat. II/314) along with new proper motion data (using data from Gaia DR1 i.e. Altmann et al. (2017A&A...600L...4A, Cat. I/339), Tian et al. (2017ApJS..232....4T)) to construct catalogues of objects in Upper Scorpius. (8 data files).

  13. ADST Version Description Document for the BDS-D MCC/Masscomp Host 1.0.0.

    Science.gov (United States)

    1993-02-02

    Turnover revision 1.1 date: 1993/02101 15:50:21; author: cm- adsL state: Exp; Initial Verion 1.0.0 RCS file: Jsrc/mcc/libmcc/RCSlradio.c,v Working file...1.1 description: Initial MCC I Masscomp Turnover revision 1.1 date: 1993JO2/01 15:15:27; author cm- adsL state: Exp; Initial Version 1.0.0 I10 U ADST

  14. The invasion history, distribution and colour pattern forms of the harlequin ladybird beetle Harmonia axyridis (Pall.) (Coleoptera, Coccinellidae) in Slovakia, Central Europe.

    Science.gov (United States)

    Panigaj, Lubomír; Zach, Peter; Honěk, Alois; Nedvěd, Oldřich; Kulfan, Ján; Martinková, Zdenka; Selyemová, Diana; Viglášová, Sandra; Roy, Helen E

    2014-01-01

    The harlequin ladybird beetle Harmonia axyridis (Coleoptera, Coccinellidae) has invaded and established in Slovakia. Following unintentional introduction in 2008, the spread of the alien coccinellid was very fast. By the end of 2009, it was recorded across the whole country, and by the end of 2012 it was widely distributed and common in various habitats, particularly gardens, orchards and urban areas, where it was most frequent on trees. The rate of eastward spread was approximately 200 km year(-1), similar to the overall rate of spread in Europe. Between 2008 and 2012, the coccinellid was recorded in a total of 153 localities, in altitudes ranging from 98 to 1,250 m. Most records of this species were made in lowlands, hilly areas and valleys separating mountain ridges. However, it was only rarely documented in areas above 700 m a.s.l. The non-melanic colour form (f. succinea) was dominant along a longitudinal transect including eight urban areas across Slovakia, with the frequency of melanic forms (f. spectabilis and f. conspicua together) between 6.3 and 19.2% and a median equal to 10.5%. The invasion history and distribution of H. axyridis in Slovakia are discussed with regard to the time sequence of records, rate of spread, altitudinal distribution, anthropogenic dispersal, effective recording, proportion of melanic forms and other relevant aspects associated with the spread of this successful invader.

  15. The invasion history, distribution and colour pattern forms of the harlequin ladybird beetle Harmonia axyridis (Pall.) (Coleoptera, Coccinellidae) in Slovakia, Central Europe

    Czech Academy of Sciences Publication Activity Database

    Panigaj, L.; Zach, P.; Honěk, A.; Nedvěd, Oldřich; Kulfan, J.; Martínková, Z.; Selyemová, D.; Viglášová, S.; Roy, H. E.

    -, č. 412 (2014), s. 89-102 ISSN 1313-2989 Grant - others:Slovak Research and Development Agency(SK) APVV 0200/11; Grant Agency of Ministry of Education and SAS(SK) 1/1025/12; Grant Agency of Ministry of Education and SAS(SK) 2/0035/13; Grant Agency of Ministry of Education and SAS(SK) 2/0157/11; Mze ČR(CZ) QH82047; MŠMT ČR(CZ) 7AMB12SK141; EU COST(CZ) TD1209 Program:FA Institutional support: RVO:60077344 Keywords : alien * altitude * colour morphs Subject RIV: EH - Ecology, Behaviour Impact factor: 0.933, year: 2014 http://europepmc.org/articles/PMC4042697;jsessionid=aEQnuIZkqJpBc2xpenqy.0

  16. The invasion history, distribution and colour pattern forms of the harlequin ladybird beetle Harmonia axyridis (Pall. (Coleoptera, Coccinellidae in Slovakia, Central Europe

    Directory of Open Access Journals (Sweden)

    Ľubomír Panigaj

    2014-05-01

    Full Text Available The harlequin ladybird beetle Harmonia axyridis (Coleoptera, Coccinellidae has invaded and established in Slovakia. Following unintentional introduction in 2008, the spread of the alien coccinellid was very fast. By the end of 2009, it was recorded across the whole country, and by the end of 2012 it was widely distributed and common in various habitats, particularly gardens, orchards and urban areas, where it was most frequent on trees. The rate of eastward spread was approximately 200 km year-1, similar to the overall rate of spread in Europe. Between 2008 and 2012, the coccinellid was recorded in a total of 153 localities, in altitudes ranging from 98 to 1,250 m. Most records of this species were made in lowlands, hilly areas and valleys separating mountain ridges. However, it was only rarely documented in areas above 700 m a.s.l. The non-melanic colour form (f. succinea was dominant along alongitudinal transect including eight urban areas across Slovakia, with the frequency of melanic forms (f. spectabilis and f. conspicua together between 6.3 and 19.2% and a median equal to 10.5%. The invasion history and distribution of H. axyridis in Slovakia are discussed with regard to the time sequence of records, rate of spread, altitudinal distribution, anthropogenic dispersal, effective recording, proportion of melanic forms and other relevant aspects associated with the spread of this successful invader.

  17. Molecular identification of Botrytis cinerea, Botrytis paeoniae and Botrytis pseudocinerea associated with gray mould disease in peonies (Paeonia lactiflora Pall.) in Southern Chile.

    Science.gov (United States)

    Muñoz, Gastón; Campos, Felipe; Salgado, Daisy; Galdames, Rafael; Gilchrist, Lucy; Chahin, Gabriela; Andrade, Orlando

    2016-01-01

    In Chile, the peony is the most important ornamental flower exported from the country. Gray mould is a phytopathological problem of this crop. This disease is caused by Botrytis cinerea and Botrytis paeoniae. We carried out the first survey of Botrytis species associated with peony gray mould in Southern Chile to estimate the diversity of these pathogens. Diseased peony leaves were collected from seven locations in Southern Chile covering a distance of 300km. The Botrytis isolates obtained were studied by morphological and molecular methods. Finally, a PCR assay using primers based on the necrosis and ethylene-inducing protein gene (nep1) was used to specifically identify B. paeoniae. Seventeen isolates belonging to Botrytis genus were obtained, and all of them were pathogenic to peonies when inoculated in plants grown in a greenhouse. Morphological analyses showed that four isolates shared common characteristics, which distinguish them from the rest. Homology and phylogenetic analysis of G3PDH, as well as determination of the Bc-hch allele, allowed us to identify 12 isolates as B. cinerea, 4 as B. paeoniae and one isolate as Botrytis pseudocinerea. The PCR assay was found to be specific to B. paeoniae, amplifying a single band of 470bp. Three Botrytis species involved in peony gray mould disease are present in Chile. This is the first time that both B. paeoniae and B. pseudocinerea have been reported to be present in the country and also that they affect peonies. Finally, to our knowledge, the PCR based method herein described is the first of its kind to be used to identify B. paeoniae. Copyright © 2014 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

  18. Muusikamaailm : CPE Bachi käsikirjad tagasi Saksamaale. Täna uusooper Londonis. Theodorakise ooperid plaadil. David Golub lahkunud. Preemia Palle Mikkelborgile / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Ukraina nõustus tagastama Saksamaale C.P.E. Bachi muusikakäsikirjad, mis Nõukogude Liidu armee sealt II Maailmasõja ajal ära viis. Inglise Rahvusooperis lavastuvast D.Saweri ooperist "From Morning to Midnight". M.Theodorakise kolm ooperit (antiiktriloogia "Elektra", "Antigone" ja "Medeia") ilmusid seoses maestro 75. juubeliga kaheksal CD-plaadil. Lühidalt D.Golubist. Põhjamaade Nõukogu tänavuse muusikapreemia võitis P.Mikkelborg

  19. ENVIRONMENTAL TEHNOLOGY VERIFICATION REPORT - PHYSICAL REMOVAL OF MICROBIAL CONTAMINATION AGENTS IN DRINKING WATER, KINETICO INCORPORATED PALL/KINETICO PUREFECTA™ DRINKING WATER TREATMENT SYSTEM (POU)

    Science.gov (United States)

    The Purefecta™ was tested for removal of bacteria and viruses at NSF International's Drinking Water Treatment Systems Laboratory. Kinetico submitted 10 units for testing, which were split into two groups of five. One group received 25 days of conditioning prior to challeng...

  20. [Analysis of the ITS1/ITS2 nuclear spacers and the secondary structure of 5.8S rRNA gene in endemic species Bellevalia sarmatica (Pall. ex Georgi) Woronow and related species of the subfamily scilloideae].

    Science.gov (United States)

    Trifonova, A A; Filyushin, M A; Kochieva, E Z; Kudryavtsev, A M

    2016-05-01

    Sequence variability of the ITS spacers and 5.8S rRNA gene was examined in 11 accessions of the subfamily Scilloideae, including seven accessions of rare and endangered species Bellevalia sarmatica from Volgograd region. The intraspecific polymorphism level of the examined ITS1–5.8S–ITS2 sequence of B. sarmatica accessions constituted 1.3%. The phylogenetic position of B. sarmatica within the genus Bellevalia was determined. It was demonstrated that B. sarmatica belonged to the section Nutantes, and the most closely related species were B. webbiana and B. dubia. Nucleotide substitutions in the 5.8S rRNA gene sequence of the analyzed Scilloideae accessions were identified and studied. The predicted secondary structure of 5.8S rRNA gene was constructed. It was demonstrated that in the examined accessions, mutations in the 5.8S rRNA gene were mainly localized in the third hairpin region and had no effect on the secondary structure of the 5.8S rRNA molecule.

  1. Extraction and Separation of Vitisin D, Ampelopsin B and cis-Vitisin A from Iris lactea Pall. var. chinensis (Fisch.) Koidz by Alkaline Extraction–Acid Precipitation and High-Speed Counter-Current Chromatography

    Science.gov (United States)

    Lv, Huanhuan; Zhou, Wenna; Wang, Xiaoyan; Wang, Zhenhua; Suo, Yourui; Wang, Honglun

    2016-01-01

    Naturally occurring oligostilbenes are receiving more attention because they exhibit several beneficial effects for health, including hepatoprotective, antitumor, anti-adipogenic, antioxidant, antiaging, anti-inflammatory, anti-microbial, antiviral, immunosuppressive and neuroprotective activities. Thus, they could be of some potentially therapeutic values for several diseases. In this study, we adopted the alkaline extraction–acid precipitation (AEAP) method for extraction of oligostilbenes from the seed kernel of Iris lactea. Then, the high-speed counter-current chromatography (HSCCC) was used for preparative isolation and purification of oligostilbenes from the AEAP extracts. Finally, three oligostilbenes, namely vitisin D (73 mg), ampelopsin B (25 mg) and cis-vitisin A (16 mg), were successfully fractionated by HSCCC with a two-phase solvent system composed of n-hexane–ethyl acetate–methanol–water (2:5:3:6, v/v/v/v) from 300 mg of the AEAP extracts in ∼190 min. The purities of the three isolated oligostilbenes were all over 95.0% as analyzed by high performance liquid chromatography. They all were isolated from I. lactea for the first time. The method of AEAP for the preparation of the oligostilbene-enriched crude sample was simple, and the HSCCC technique for the isolation and purification of oligostilbenes was efficient. PMID:26847919

  2. Rapid Separation of Three Proanthocyanidin Dimers from Iris lactea Pall. var. Chinensis (Fisch.) Koidz by High-Speed Counter-Current Chromatography With Continuous Sample Load and Double-Pump Balancing Mode.

    Science.gov (United States)

    Lv, Huanhuan; Yuan, Zhenzhen; Wang, Xiaoyan; Wang, Zhenhua; Suo, Yourui; Wang, Honglun

    2015-01-01

    The dried seeds of Iris lactea have been used in traditional Chinese medicine. Previous studies have been focused on irisquinones while other chemical components are rarely reported. To establish an efficient high-speed counter-current chromatography (HSCCC) separation method with continuous sample load (CSL) and double-pump balancing (DPB) mode to isolate proanthocyanidins from I. lactea. Firstly, an ethyl acetate extract of I. lactea was pre-fractionated by silica column chromatography for the enrichment of proanthocyanidins. Secondly, the enriched proanthocyanidins sample (EPS) was further fractionated by HSCCC with a two-phase solvent system ethyl acetate:n-butanol:water (9:1:10, v/v/v) using DPB mode. The flow rate of the two phases was 2.2 mL/min, the revolution speed was 900 rpm, the separation temperature was 30 °C and the detection wavelength was 280 nm. Finally, the structures of the three isolated proanthocyanidins were elucidated by spectroscopic methods and compared with published data. Under the optimized conditions, 600 mg of the EPS with six continuous injections (100 mg/time) was fractionated, yielding 57 mg of prodelphinidin B3, 198 mg of procyanidin B3, and 162 mg of procyanidin B1, at purities of 97.2%, 98.1% and 97.3%, respectively. The HSCCC separation method with CSL and DPB proved to be rapid, convenient and economical, constituting an efficient strategy for the isolation of proanthocyanidins. Copyright © 2015 John Wiley & Sons, Ltd.

  3. Final report bridge design system analysis and modernization.

    Science.gov (United States)

    2016-09-27

    The Bridge Design System (BDS) is an in-house software program developed by the Michigan Department of Transportations : (MDOT) Bridge Design Unit. The BDS designs bridges according to the required specifications, and outputs corresponding design ...

  4. Optimização terapêutica na DPOC

    OpenAIRE

    Dias, Hermínia Brites

    2010-01-01

    Objectivos do estudo: identificar os principais broncodilatadores inalados e o seu mecanismo básico de acção; caracterizar as respostas funcionais aos BDs; caracterizar os principais dispositivos de administração dos BDs inalados; caracterizar o procedimento da administração dos BDs inalados de acordo com o dispositivo utilizado.

  5. Hi-C OBSERVATIONS OF SUNSPOT PENUMBRAL BRIGHT DOTS

    Energy Technology Data Exchange (ETDEWEB)

    Alpert, Shane E. [Department of Physics and Astronomy, Rice University, Houston, TX, 77005 (United States); Tiwari, Sanjiv K.; Moore, Ronald L.; Winebarger, Amy R.; Savage, Sabrina L. [NASA Marshall Space Flight Center, ZP 13, Huntsville, AL 35812 (United States)

    2016-05-01

    We report observations of bright dots (BDs) in a sunspot penumbra using High Resolution Coronal Imager (Hi-C) data in 193 Å and examine their sizes, lifetimes, speeds, and intensities. The sizes of the BDs are on the order of 1″ and are therefore hard to identify in the Atmospheric Imaging Assembly (AIA) 193 Å images, which have a 1.″2 spatial resolution, but become readily apparent with Hi-C's spatial resolution, which is five times better. We supplement Hi-C data with data from AIA's 193 Å passband to see the complete lifetime of the BDs that appeared before and/or lasted longer than Hi-C's three-minute observation period. Most Hi-C BDs show clear lateral movement along penumbral striations, either toward or away from the sunspot umbra. Single BDs often interact with other BDs, combining to fade away or brighten. The BDs that do not interact with other BDs tend to have smaller displacements. These BDs are about as numerous but move slower on average than Interface Region Imaging Spectrograph (IRIS) BDs, which was recently reported by Tian et al., and the sizes and lifetimes are on the higher end of the distribution of IRIS BDs. Using additional AIA passbands, we compare the light curves of the BDs to test whether the Hi-C BDs have transition region (TR) temperatures like those of the IRIS BDs. The light curves of most Hi-C BDs peak together in different AIA channels, indicating that their temperatures are likely in the range of the cooler TR (1−4 × 10{sup 5} K).

  6. Hi-C Observations of Penumbral Bright Dots

    Science.gov (United States)

    Alpert, S. E.; Tiwari, S. K.; Moore, R. L.; Savage, S. L.; Winebarger, A. R.

    2014-01-01

    We use high-quality data obtained by the High Resolution Coronal Imager (Hi-C) to examine bright dots (BDs) in a sunspot's penumbra. The sizes of these BDs are on the order of 1 arcsecond (1") and are therefore hard to identify using the Atmospheric Imaging Assembly's (AIA) 0.6" pixel(exp -1) resolution. These BD become readily apparent with Hi-C's 0.1" pixel(exp -1) resolution. Tian et al. (2014) found penumbral BDs in the transition region (TR) by using the Interface Region Imaging Spectrograph (IRIS). However, only a few of their dots could be associated with any enhanced brightness in AIA channels. In this work, we examine the characteristics of the penumbral BDs observed by Hi-C in a sunspot penumbra, including their sizes, lifetimes, speeds, and intensity. We also attempt to find any association of these BDs to the IRIS BDs. There are fewer Hi-C BDs in the penumbra than seen by IRIS, though different sunspots were studied. We use 193 Angstroms Hi-C data from July 11, 2012 which observed from approximately 18:52:00 UT- 18:56:00 UT and supplement it with data from AIA's 193 Angstrom passband to see the complete lifetime of the dots that were born before and/or lasted longer than Hi- C's 5-minute observation period. We use additional AIA passbands and compare the light curves of the BDs at different temperatures to test whether the Hi-C BDs are TR BDs. We find that most Hi-C BDs show clear movement, and of those that do, they move in a radial direction, toward or away from the sunspot umbra. Single BDs interact with other BDs, combining to fade away or brighten. The BDs that do not interact with other BDs tend to move less. Many of the properties of our BDs are similar to the extreme values of the IRIS BDs, e.g., they move slower on average and their sizes and lifetimes are on the higher end of the IRIS BDs. We infer that our penumbral BDs are the large-scale end of the distribution of BDs observed by IRIS.

  7. Papers

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    The chapters in this Volume 7 of a series of PAPERS are based on papers published in the period 2004 - 2008 authored/co-authored by Palle Thoft-Christensen......The chapters in this Volume 7 of a series of PAPERS are based on papers published in the period 2004 - 2008 authored/co-authored by Palle Thoft-Christensen...

  8. Antinous: Saint or Criminal?

    DEFF Research Database (Denmark)

    Heede, Dag

    2017-01-01

    An exploration of the Antinous myth in early modern Danish homosexual literature and drama around 1800, including interpretations of two forgotten dramas: "Hadrian" by Konrad Simonsen and "Antinous" by Palle Rosenkrantz.......An exploration of the Antinous myth in early modern Danish homosexual literature and drama around 1800, including interpretations of two forgotten dramas: "Hadrian" by Konrad Simonsen and "Antinous" by Palle Rosenkrantz....

  9. Dental students consistency in applying the ICDAS system within paediatric dentistry.

    Science.gov (United States)

    Foley, J I

    2012-12-01

    To examine dental students' consistency in utilising the International Caries Detection and Assessment System (ICDAS) one and three months after training. A prospective study. All clinical dental students (Year Two: BDS2; Year Three: BDS3; Year Four: BDS4) as part of their education in Paediatric Dentistry at Aberdeen Dental School (n = 56) received baseline training by two "gold-standard" examiners and were advised to complete the 90-minute ICDAS e-learning program. Study One: One month later, the occlusal surface of 40 extracted primary and permanent molar teeth were examined and assigned both a caries (0-6 scale) and restorative code (0-9 scale). Study Two: The same teeth were examined three months later. Kappa statistics were used to determine inter- and intra-examiner reliability at baseline and after three months. In total, 31 students (BDS2: n = 9; BDS3: n = 8; BDS4: n = 14) completed both examinations. The inter-examiner reliability kappa scores for restoration codes for Study One and Study Two were: BDS2: 0.47 and 0.38; BDS3: 0.61 and 0.52 and BDS4: 0.56 and 0.52. The caries scores for the two studies were: BDS2: 0.31 and 0.20; BDS3: 0.45 and 0.32 and BDS4: 0.35 and 0.34. The intra-examiner reliability range for restoration codes were: BDS2: 0.20 to 0.55; BDS3: 0.34 to 0.72 and BDS4: 0.28 to 0.80. The intra-examiner reliability range for caries codes were: BDS2: 0.35 to 0.62; BDS3: 0.22 to 0.53 and BDS4: 0.22 to 0.65. The consistency of ICDAS codes varied between students and also, between year groups. In general, consistency was greater for restoration codes.

  10. Assessment of the Contribution of BeiDou GEO, IGSO, and MEO Satellites to PPP in Asia-Pacific Region.

    Science.gov (United States)

    Zhao, Qile; Wang, Chen; Guo, Jing; Liu, Xianglin

    2015-12-01

    In contrast to the US Global Positioning System (GPS), the Russian Global Navigation Satellite System (GLONASS) and the European Galileo, the developing Chinese BeiDou satellite navigation system (BDS) consists of not only Medium Earth Orbit (MEO), but also Geostationary Orbit (GEO) as well as Inclined Geosynchronous Orbit (IGSO) satellites. In this study, the Precise Point Positioning (PPP) and PPP with Integer Ambiguity Resolution (IAR) are obtained. The contributions of these three different types of BDS satellites to PPP in Asia-Pacific region are assessed using data from selected 20 sites over more than four weeks. By using various PPP cases with different satellite combinations, in general, the largest contribution of BDS IGSO among the three kinds of BDS satellites to the reduction of convergence time and the improvement of positioning accuracy, particularly in the east direction, is identified. These PPP cases include static BDS only solutions and static/kinematic ambiguity-float and -fixed PPP with the combination of GPS and BDS. The statistical results demonstrate that the inclusion of BDS GEO and MEO satellites can improve the observation condition and result in better PPP performance as well. When combined with GPS, the contribution of BDS to the reduction of convergence time is, however, not as significant as that of GLONASS. As far as the positioning accuracy is concerned, GLONASS improves the accuracy in vertical component more than BDS does, whereas similar improvement in horizontal component can be achieved by inclusion of BDS IGSO and MEO as GLONASS.

  11. Assessment of the Contribution of BeiDou GEO, IGSO, and MEO Satellites to PPP in Asia–Pacific Region

    Science.gov (United States)

    Zhao, Qile; Wang, Chen; Guo, Jing; Liu, Xianglin

    2015-01-01

    In contrast to the US Global Positioning System (GPS), the Russian Global Navigation Satellite System (GLONASS) and the European Galileo, the developing Chinese BeiDou satellite navigation system (BDS) consists of not only Medium Earth Orbit (MEO), but also Geostationary Orbit (GEO) as well as Inclined Geosynchronous Orbit (IGSO) satellites. In this study, the Precise Point Positioning (PPP) and PPP with Integer Ambiguity Resolution (IAR) are obtained. The contributions of these three different types of BDS satellites to PPP in Asia–Pacific region are assessed using data from selected 20 sites over more than four weeks. By using various PPP cases with different satellite combinations, in general, the largest contribution of BDS IGSO among the three kinds of BDS satellites to the reduction of convergence time and the improvement of positioning accuracy, particularly in the east direction, is identified. These PPP cases include static BDS only solutions and static/kinematic ambiguity-float and -fixed PPP with the combination of GPS and BDS. The statistical results demonstrate that the inclusion of BDS GEO and MEO satellites can improve the observation condition and result in better PPP performance as well. When combined with GPS, the contribution of BDS to the reduction of convergence time is, however, not as significant as that of GLONASS. As far as the positioning accuracy is concerned, GLONASS improves the accuracy in vertical component more than BDS does, whereas similar improvement in horizontal component can be achieved by inclusion of BDS IGSO and MEO as GLONASS. PMID:26633406

  12. Comprehensive Comparisons of Satellite Data, Signals, and Measurements between the BeiDou Navigation Satellite System and the Global Positioning System †

    Science.gov (United States)

    Jan, Shau-Shiun; Tao, An-Lin

    2016-01-01

    The Chinese BeiDou navigation satellite system (BDS) aims to provide global positioning service by 2020. The combined use of BDS and Global Positioning System (GPS) is proposed to provide navigation service with more stringent requirements. Actual satellite data, signals and measurements were collected for more than one month to analyze the positioning service qualities from both BDS and GPS. In addition to the conversions of coordinate and timing system, five data quality analysis (DQA) methods, three signal quality analysis (SQA) methods, and four measurement quality analysis (MQA) methods are proposed in this paper to improve the integrated positioning performance of BDS and GPS. As shown in the experiment results, issues related to BDS and GPS are resolved by the above proposed quality analysis methods. Thus, the anomalies in satellite data, signals and measurements can be detected by following the suggested resolutions to enhance the positioning performance of the combined use of BDS and GPS in the Asia Pacific region. PMID:27187403

  13. Binge drinking during adolescence and young adulthood is associated with deficits in verbal episodic memory.

    Science.gov (United States)

    Carbia, Carina; Cadaveira, Fernando; Caamaño-Isorna, Francisco; Rodríguez-Holguín, Socorro; Corral, Montse

    2017-01-01

    Binge drinking (BD), a harmful pattern of alcohol consumption, is common during adolescence. Young adults with alcohol use disorders exhibit hippocampal alterations and episodic memory deficits. However, it is not known how these difficulties progress in community BD adolescents. Our objective was to analyze the relationship between BD trajectory and verbal episodic memory during the developmental period spanning from adolescence and to early adulthood. An initial sample of 155 male and female first-year university students with no other risk factors were followed over six years. Participants were classified as stable non-BDs, stable BDs and ex-BDs according to the third AUDIT item. At baseline, participants comprised 36 ♂/ 40 ♀ non-BDs (18.58 years), 40 ♂/ 39 ♀ BDs (18.87 years), and at the third follow-up, they comprised 8 ♂/ 8 ♀ stable non-BDs (25.49 years), 2 ♂/ 2 ♀ stable BDs (25.40) and 8 ♂/ 12 ♀ ex-BDs (24.97 years). Episodic memory was assessed four times with the Logical Memory subtest (WMS-III) and the Rey Auditory Verbal Learning Test (RAVLT). Generalized linear mixed models were applied. The results showed that, relative to non-BDs, stable BDs presented difficulties in immediate and delayed recall in the Logical Memory subtest. These difficulties remained stable over time. The short-term ex-BDs continued to display difficulties in immediate and delayed recall in the Logical Memory subtest, but long-term ex-BDs did not. The effects were not influenced by age of alcohol onset, frequency of cannabis use, tobacco use or psychopathological distress. In conclusion, BD during adolescence and young adulthood is associated with episodic memory deficits. Abandoning the BD pattern may lead to partial recovery. These findings are consistent with the vulnerability of the adolescent hippocampus to the neurotoxic effects of alcohol.

  14. 7 CFR 361.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ...—Cucurbita pepo L., C. moschata (Duchesne) Poiret, and C. maxima Duchesne Radish—Raphanus sativus L. Rhubarb...—Tetragonia tetragonioides (Pall.) Ktze. Squash—Cucurbita pepo L., C. moschata (Duchesne) Poiret, and C...

  15. Oxygen diffusion in fish embryos

    NARCIS (Netherlands)

    Kranenbarg, S.

    2002-01-01

    <p>All vertebrate embryos pass through a developmental period of remarkably low morphological variability. This period has been called phylotypic period. During the phylotypic period, organogenesis takes place, including blood vessel development. Before the phylotypic

  16. Uikala prügila sai puhastusseadmed / Külli Kriis

    Index Scriptorium Estoniae

    Kriis, Külli, 1961-

    2004-01-01

    Ilmunud ka: Severnoje Poberezhje, 22. mai 2004, lk. 3. 21. mail 2004 Ida-Virumaal Uikala prügilas avatud puhastusseadmete kompleksist, mille valmistas ja paigaldas rahvusvaheline ettevõte Pall Corporation

  17. 76 FR 36551 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2011-06-22

    ... demonstrated against various forms of cancer, including hairy cell leukemia (HCL) and pediatric acute lymphocytic leukemia (pALL). Although early variations these targeted toxins have demonstrated efficacy upon...

  18. African Journal of Biotechnology - Vol 12, No 31 (2013)

    African Journals Online (AJOL)

    induced fatty liver model of consecutive extracts from Rosa davurica Pall · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ying Wei, Muyi Cai, Ruizeng Gu, Jun Lu, Feng Lin, Baoping Ji ...

  19. MIDLINE LETHAL GRANULOMA COMPLICATING PREGNANCY ...

    African Journals Online (AJOL)

    Kateee

    East African Medical Journal Vol. 80. No. 7 July 2003. MIDLINE LETHAL GRANULOMA COMPLICATING PREGNANCY: CASE REPORT. B.D.O. Saheeb, BDS, FWACS, FICS, FDS, RCS (Edin) Senior Lecturer/Consultant, and M.A. Ojo, BDS, MMed Sc, Dip Maxfac Rad, Associate Professor/Consultant. Department of oral ...

  20. 76 FR 10591 - Notice of Availability; Recommended Use of Body Weight3∕4 as the Default Method in Derivation of...

    Science.gov (United States)

    2011-02-25

    ... Use of Body Weight[bds3][bdsol][bds4] as the Default Method in Derivation of the Oral Reference Dose... announces the availability of ``Recommended Use of Body Weight 3/4 as the Default Method in Derivation of... Forum, composed of scientists from across the Agency. Selected drafts were peer reviewed internally by...

  1. Bodily Distress Syndrome

    DEFF Research Database (Denmark)

    Budtz-Lilly, Anna; Vestergaard, Mogens; Moth, Grete

    2011-01-01

    AIM: Medically unexplained or functional symptoms and disorders are common in primary care. Empirical research has proposed specific criteria for a new unifying diagnosis for functional disorders and syndromes: Bodily Distress Syndrome (BDS). This new diagnosis is expected to be integrated...... into the upcoming versions of classification systems. The objective of this study is to estimate the prevalence and describe the characteristics of patients with BDS in primary care. Method: We recruited a cohort of 4870 patients of 18+ years from the Central Denmark Region from December 2008 until December 2009......: We will present data on the prevalence of BDS in a primary care population as well as the characteristics of patients with BDS. Characterization will include age, gender, severity of BDS, self evaluated health, health anxiety and mental health. Conclusion: Results from this study will make precise...

  2. Developing and Reflecting on a Black Disability Studies Pedagogy: Work from the National Black Disability Coalition

    Directory of Open Access Journals (Sweden)

    Jane Dunhamn

    2015-05-01

    Full Text Available This collection of writing has grown from the work of the National Black Disability Coalition, led by Jane Dunhamn and Leroy Moore. The Coalition met on June 7, 2013, in the historic Shiloh Baptist Church in Trenton, New Jersey to discuss the future of Black Disability Studies (BDS. Since that time, members of the Coalition have written an outline for a BDS course, presented at conferences, and developed strategies to incorporate BDS into the disciplines of Black Studies and Disability Studies. We have also reflected deeply on what the introduction of BDS will mean, both for Black Studies and for disability studies. Our writings in this collection are intended to mark the work of the National Black Disability Coalition thus far, but also to provide a platform from which further work in BDS can grow. By underscoring the development and potential of BDS, this article articulates the need for BDS within mainstream disability studies, and advocates for BDS not to be taken as a marginalized special-topic course, but rather to be engaged in every and at the heart of Disability Studies courses and pedagogies. Although we believe that BDS should be integrated into every Disability Studies course, we recognize that, like disability itself, it cannot simply be “added and stirred”; rather, the inclusion of BDS is a paradigm-shifting change. The pieces included in this collection are enactments of an ongoing conversation--a conversation that we hope the readers of Disability Studies Quarterly will join thoughtfully. The sections comprise statements from the leaders of the National Black Disability Coalition, Jane Dunhamn and Leroy Moore; reflective writings from three instructors and two students of Black Disability Studies; and a copy of the course outline.

  3. Orbit determination using real tracking data from FY3C-GNOS

    Science.gov (United States)

    Xiong, Chao; Lu, Chuanfang; Zhu, Jun; Ding, Huoping

    2017-08-01

    China is currently developing the BeiDou Navigation Satellite System, also known as BDS. The nominal constellation of BDS (regional), which had been able to provide preliminary regional positioning and navigation functions, was composed of fourteen satellites, including 5 GEO, 5 IGSO and 4 MEO satellites, and was realized by the end of 2013. Global navigation satellite system occultation sounder (GNOS) on board the Fengyun3C (FY3C) satellite, which is the first BDS/GPS compatible radio occultation (RO) sounder in the world, was launched on 23 September 2013. The GNOS instrument is capable of tracking up to 6 BeiDou satellites and more than 8 GPS satellites. We first present a quality analysis using 1-week onboard BDS/GPS measurements collected by GNOS. Satellite visibility, multipath combination and the ratio of cycle slips are analyzed. The analysis of satellite visibility shows that for one week the BDS receiver can track up to 6 healthy satellites. The analysis of multipath combinations (MPC) suggests more multipath present for BDS than GPS for the CA code (B1 MPC is 0.597 m, L1 MPC is 0.326 m), but less multipath for the P code (B2 MPC is 0.421 m, L2 MPC is 0.673 m). More cycle slips occur for the BDS than for the GPS receiver as shown by the ratio of total satellites/cycle slips observed over a 24 h period. Both the maximum value and average of the ratio of cycle slips based on BDS measurements is 72/50.29, which is smaller than 368/278.71 based on GPS measurements. Second, the results of reduced dynamic orbit determination using BDS/GPS code and phase measurements, standalone BDS SPP (Single Point Positioning) kinematic solution and real-time orbit determination using BDS/GPS code measurements are presented and analyzed. Using an overlap analysis, the orbit consistency of FY3C-GNOS is about 3.80 cm. The precision of BDS only solutions is about 22 cm. The precision of FY3C-GNOS orbit with the Helmert variance component estimation are improved slightly after

  4. Multiple somatic symptoms in primary care patients: a cross-sectional study of consultation content, clinical management strategy and burden of encounter

    DEFF Research Database (Denmark)

    Rask, Mette Trøllund; Carlsen, Anders Helles; Budtz-Lilly, Anna

    2016-01-01

    Bodily distress syndrome (BDS) er en ny forskningsdiagnose for medicinsk uforklarede symptomer. Denne artikel præsenterer et tværsnitsstudie, som har undersøgt konsultationens indhold, de valgte kliniske strategier, tidsforbruget og den praktiserende læges opfattelse af tyngden af konsultationer...... med patienter med BDS. Resultaterne viser, at patienter med BDS generelt har sammensatte og komplekse behov relateret til både det psykosociale og det biomedicinske område. Lægerne synes at sikre kontinuitet i behandlingen af denne patientgruppe gennem strategier som at se an med henvendelse ved behov...

  5. Trends in botanical dietary supplement use among US adults by cancer status: The National Health and Nutrition Examination Survey, 1999 to 2014.

    Science.gov (United States)

    Li, Chao; Hansen, Richard A; Chou, Chiahung; Calderón, Angela I; Qian, Jingjing

    2018-03-15

    Patients with cancer may use botanical dietary supplements (BDS) in an attempt to manage the side effects of chemotherapy, yet evidence about BDS use among patients with cancer is limited. The authors examined trends in BDS use among US adults according to cancer status and patient characteristics. A serial, cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey from 1999 through 2014 (n = 43,644). Self-reported cancer diagnosis history and any BDS use in the preceding 30 days were determined. The prevalence of BDS use was calculated in each cycle for respondents with and without cancer, both overall and by patient characteristics. Simple linear regression models were applied to test for trends in BDS use at a 2-sided P value < .05. Multiple logistic regression models were performed to identify the patient factors associated with BDS use. The results were weighted to represent national estimates. The prevalence of BDS use was greater among participants who had cancer compared with participants who did not have cancer, but trends remained stable during 1999 through 2014 for both groups. Trends in BDS use declined in patients with cancer who were older (P trend  = .047), had a low annual family income (P trend  = .028), and had a lower education level (P trend  = .004). Among the respondents without cancer, trends in BDS use declined in those who were middle-aged (P trend  = .025), non-Hispanic whites (P trend  = .025), those with a lower education level (P trend  = .011), and those who were not receiving prescription medication (P trend  = .036). Patient age, sex, race/ethnicity, income, education, and health conditions were associated with BDS use. The overall use of BDS remained stable during 1999 through 2014 for US adults with and without cancer, but it varied by individual characteristics. Cancer 2018;124:1207-15. © 2017 American Cancer Society. © 2017 American Cancer

  6. La psicología social en España : estructuras de comunidades

    OpenAIRE

    Iñiguez Rueda, Lupicinio; Muñoz Justicia, Juan; Peñaranda Cólera, Mª Carmen; Martínez, Luz María

    2006-01-01

    This study forms part of a ‘social psychology of science” (Domènech, Íñiguez, Pallí y Tirado 2000; Iñiguez y Pallí, 2002; Moscovici, 1993; Shadish & Fuller, 1994; Shadish & Neimeyer, 1989). Social psychology’s contribution to the social understanding of science and technology is in its study of the interactional and social factors involved in the production of scientific knowledge, exploring the idea that knowledge is the product of joint endeavour. In the work reported here we take Social Ps...

  7. Stemcell Information: SKIP000748 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available B1345. Ph1 chromosome-positive human acute lymphoblastic leukemia cell line. Single Ph1 chromosome observed. 白血病... SKIP000748 ... acute lymphoblastic leukemia cell line 急性リンパ芽球 ... Diseased PALL-2 PALL...c and molecular analysis of Ph1-chromosome-positive acute lymphoblastic leukemia cell lines. Miyagi T, Ohyas...-2 JCRB1345 JCRB1345 急性リンパ性白血病 C910 Acute lymphoblastic leukaemia [ALL] 613065 ... -- Male ... Yes No JCR

  8. Enhancing Diversity in Biomedical Data Science.

    Science.gov (United States)

    Canner, Judith E; McEligot, Archana J; Pérez, María-Eglée; Qian, Lei; Zhang, Xinzhi

    2017-01-01

    The gap in educational attainment separating underrepresented minorities from Whites and Asians remains wide. Such a gap has significant impact on workforce diversity and inclusion among cross-cutting Biomedical Data Science (BDS) research, which presents great opportunities as well as major challenges for addressing health disparities. This article provides a brief description of the newly established National Institutes of Health Big Data to Knowledge (BD2K) diversity initiatives at four universities: California State University, Monterey Bay; Fisk University; University of Puerto Rico, Río Piedras Campus; and California State University, Fullerton. We emphasize three main barriers to BDS careers (ie, preparation, exposure, and access to resources) experienced among those pioneer programs and recommendations for possible solutions (ie, early and proactive mentoring, enriched research experience, and data science curriculum development). The diversity disparities in BDS demonstrate the need for educators, researchers, and funding agencies to support evidence-based practices that will lead to the diversification of the BDS workforce.

  9. Tanzania Journal of Development Studies - Vol 14, No 1-2 (2014)

    African Journals Online (AJOL)

    Modeling Business Development Services (BDS) in the Tanzania SMEs Market: Theoretical and Conceptual Framework Issues · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. O.K. Mbura, Merezia W. Bambaganya, 13-25 ...

  10. Monitoring drinking water quality in South Africa: Designing ...

    African Journals Online (AJOL)

    , are required to submit information regarding water quality and the management thereof regularly to the national Blue Drop System (BDS). Since 2009, a trend has emerged in which urban municipalities have been shown to consistently ...

  11. 5th China Satellite Navigation Conference

    CERN Document Server

    Jiao, Wenhai; Wu, Haitao; Lu, Mingquan

    2014-01-01

    China Satellite Navigation Conference (CSNC) 2014 Proceedings presents selected research papers from CSNC2014, held on 21-23 May in Nanjing, China. The theme of CSNC2014 is 'BDS Application: Innovation, Integration and Sharing'. These papers discuss the technologies and applications of the Global Navigation Satellite System (GNSS), and the latest progress made in the China BeiDou System (BDS) especially. They are divided into 9 topics to match the corresponding sessions in CSNC2014, which broadly covered key topics in GNSS. Readers can learn about the BDS and keep abreast of the latest advances in GNSS techniques and applications.  SUN Jiadong is the Chief Designer of the Compass/ BDS, and the Academician of Chinese Academy of Sciences (CAS); JIAO Wenhai is a researcher at China Satellite Navigation Office; WU Haitao is a professor at Navigation Headquarters, CAS; LU Mingquan is a professor at Department of Electronic Engineering of Tsinghua University.

  12. Intelligent Belt Drive Systems in Hybrid Powertrains: a Multipurpose Test Rig

    OpenAIRE

    Di Napoli, Maria; Suarez Cabrera, Lester Daniel; Tonoli, Andrea; Amati, Nicola; Ruzimov, Sanjarbek

    2016-01-01

    In traditional engine setups Belt Drive Systems (BDS) are in charge of power transmission from the crankshaft to the accessories. They are complex and critical dynamic mechanisms, involving contact mechanics and vibration phenomena. The hybridization of vehicles has increased the severity of the operating conditions of these systems that have become even more critical. The traditional alternator was substituted by a Belt-Starter Generator (BSG), an electric machine that can power the BDS in p...

  13. Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.

    Science.gov (United States)

    Romano, Barbara; Borrelli, Francesca; Pagano, Ester; Cascio, Maria Grazia; Pertwee, Roger G; Izzo, Angelo A

    2014-04-15

    Colon cancer is a major public health problem. Cannabis-based medicines are useful adjunctive treatments in cancer patients. Here, we have investigated the effect of a standardized Cannabis sativa extract with high content of cannabidiol (CBD), here named CBD BDS, i.e. CBD botanical drug substance, on colorectal cancer cell proliferation and in experimental models of colon cancer in vivo. Proliferation was evaluated in colorectal carcinoma (DLD-1 and HCT116) as well as in healthy colonic cells using the MTT assay. CBD BDS binding was evaluated by its ability to displace [(3)H]CP55940 from human cannabinoid CB1 and CB2 receptors. In vivo, the effect of CBD BDS was examined on the preneoplastic lesions (aberrant crypt foci), polyps and tumours induced by the carcinogenic agent azoxymethane (AOM) as well as in a xenograft model of colon cancer in mice. CBD BDS and CBD reduced cell proliferation in tumoral, but not in healthy, cells. The effect of CBD BDS was counteracted by selective CB1 and CB2 receptor antagonists. Pure CBD reduced cell proliferation in a CB1-sensitive antagonist manner only. In binding assays, CBD BDS showed greater affinity than pure CBD for both CB1 and CB2 receptors, with pure CBD having very little affinity. In vivo, CBD BDS reduced AOM-induced preneoplastic lesions and polyps as well as tumour growth in the xenograft model of colon cancer. CBD BDS attenuates colon carcinogenesis and inhibits colorectal cancer cell proliferation via CB1 and CB2 receptor activation. The results may have some clinical relevance for the use of Cannabis-based medicines in cancer patients. Copyright © 2013 Elsevier GmbH. All rights reserved.

  14. DETECTION OF BROWN DWARF LIKE OBJECTS IN THE CORE OF NGC 3603

    International Nuclear Information System (INIS)

    Spezzi, Loredana; Beccari, Giacomo; De Marchi, Guido; Andersen, Morten; Young, Erick T.; Paresce, Francesco; Dopita, Michael A.; Panagia, Nino; Bond, Howard E.; Balick, Bruce; Calzetti, Daniela; Carollo, C. Marcella; Disney, Michael J.; Frogel, Jay A.; Hall, Donald N. B.; Holtzman, Jon A.; Kimble, Randy A.; McCarthy, Patrick J.; O'Connell, Robert W.; Ryan, Russell E. Jr

    2011-01-01

    We used near-infrared data obtained with the Wide Field Camera 3 on the Hubble Space Telescope to identify objects having the colors of brown dwarfs (BDs) in the field of the massive galactic cluster NGC 3603. These are identified through a combination of narrow- and medium-band filters which span the J and H bands and are particularly sensitive to the presence of the 1.3-1.5 μm H 2 O molecular band unique to BDs. We provide a calibration of the relationship between effective temperature and color for both field stars and BDs. This photometric method provides effective temperatures for BDs to an accuracy of ±350 K relative to spectroscopic techniques. This accuracy is shown to be not significantly affected by either stellar surface gravity or uncertainties in the interstellar extinction. We identify nine objects having effective temperatures between 1700 and 2200 K, typical of BDs, observed J-band magnitudes in the range 19.5-21.5, and that are strongly clustered toward the luminous core of NGC 3603. However, if these are located at the distance of the cluster, they are far too luminous to be normal BDs. We argue that it is unlikely that these objects are either artifacts of our data set, normal field BDs/M-type giants, or extragalactic contaminants and, therefore, might represent a new class of stars having the effective temperatures of BDs but with luminosities of more massive stars. We explore the interesting scenario in which these objects would be normal stars that have recently tidally ingested a hot Jupiter, the remnants of which are providing a short-lived extended photosphere to the central star. In this case, we would expect them to show the signature of fast rotation.

  15. Keys to open the door for blood donors to return.

    Science.gov (United States)

    Ringwald, Juergen; Zimmermann, Robert; Eckstein, Reinhold

    2010-10-01

    Because of demographic changes, the worldwide shortage of blood will likely be aggravated in the foreseeable future. Hence, the retention of already active blood donors (BDs) is becoming more and more important. Moreover, a substantial increase in blood donations could be achieved by a relatively small increase in BD return. Blood donation services are therefore well advised to understand their BDs' motivations to become regular and committed BDs and to consider this in planning BD retention programs. Focusing on the published literature of the last decade, we summaries some key recommendations in considering BD retention strategies. Whereas starting a career as a BD is mainly driven by external stimuli, becoming a committed BD needs a well-developed identity role; that is, a BD with a high level of intrinsic motivation. Active communications with the BD right from the beginning, introducing distinct measures to support the development of a BD's distinct identity, increasing convenience of the blood donation process, having well-trained and motivated staff, applying distinct measures to reduce anxiety as well as adverse events, making BDs satisfied with their blood donation experience, appropriate use of incentives, quickly recapturing temporarily deferred BDs, and appealing to BDs' personal motivations and moral norms--all of these are major keys to achieving this important aim. Copyright © 2010 Elsevier Inc. All rights reserved.

  16. Differential modulation of avian β-defensin and Toll-like receptor expression in chickens infected with infectious bronchitis virus.

    Science.gov (United States)

    Xu, Yang; Zhang, Tingting; Xu, Qianqian; Han, Zongxi; Liang, Shuling; Shao, Yuhao; Ma, Deying; Liu, Shengwang

    2015-11-01

    The host innate immune response either clears invading viruses or allows the adaptive immune system to establish an effective antiviral response. In this study, both pathogenic (passage 3, P3) and attenuated (P110) infectious bronchitis virus (IBV) strains were used to study the immune responses of chicken to IBV infection. Expression of avian β-defensins (AvBDs) and Toll-like receptors (TLRs) in 16 tissues of chicken were compared at 7 days PI. The results showed that P3 infection upregulated the expression of AvBDs, including AvBD2, 4, 5, 6, 9, and 12, while P110 infection downregulated the expression of AvBDs, including AvBD3, 4, 5, 6, and 9 in most tissues. Meanwhile, the expression level of several TLRs showed a general trend of upregulation in the tissues of P3-infected chickens, while they were downregulated in the tissues of P110-infected chickens. The result suggested that compared with the P110 strain, the P3 strain induced a more pronounced host innate immune response. Furthermore, we observed that recombinant AvBDs (including 2, 6, and 12) demonstrated obvious anti-viral activity against IBV in vitro. Our findings contribute to the proposal that IBV infection induces an increase in the messenger RNA (mRNA) expression of some AvBDs and TLRs, which suggests that AvBDs may play significant roles in the resistance of chickens to IBV replication.

  17. BeiDou/GPS Displacement Detection Using Robust Weighting Based on Moving Window

    Directory of Open Access Journals (Sweden)

    ZHANG Yunlong

    2017-05-01

    Full Text Available The positioning accuracy of Kalman model under creep deformation condition is closely related to the observation variance, which can be affected by the accuracy of weight ratio of GPS and BDS observations. To improve displacement detection accuracy, shorten convergence time of initial coordinate and reduce monitoring cost, firstly the BDS/GPS single-frequency single-difference combination model is set up by using clock-synchronized dual-antenna BDS/GPS receiver. Then the equivalent weights of GPS and BDS observations are robustly determined respectively, and the Helmert variance component estimated by introducing time-correlated forgetting factor is used to achieve the precise weight ratio between GPS and BDS observations. Finally the coordinates are calculated using the extended Kalman filter by updating observed variance in real-time. According to the experiment, for the short baseline (1 km, BDS/GPS robust precise weighting Kalman method can shorten convergence time of initial coordinate significantly, which is suitable for monitoring the deformation body with creep characteristics, and the displacement detection accuracy can reach sub-millimeter level. Moreover the displacement convergence rate is inversely related to the length of moving window approximately.

  18. Social Media Rhetoric of the Transnational Palestinian-led Boycott, Divestment, and Sanctions Movement

    Directory of Open Access Journals (Sweden)

    Jennifer Hitchcock

    2016-02-01

    Full Text Available This article uses rhetorical analysis to determine the effectiveness and characteristics of social media usage by the Boycott, Divestment, and Sanctions (BDS movement targeting Israel. Hundreds of local student, community, and religious groups in the United States use social media platforms such as Twitter and Facebook to promote BDS discourse and organize local BDS-related events. Even though social media platforms are important for an international movement composed of a very dispersed population, with millions of Palestinians also living under military occupation, the history of traditional media use during the First Intifada also suggests that social media are not necessary for mobilizing Palestinians at the local level. A preliminary rhetorical analysis of several BDS-related Facebook pages and Twitter accounts reveals that the BDS movement’s social media usage functions similarly in some ways to other contemporary mass movements by facilitating on-the-ground actions and delivering useful information to supporters. BDS movement social media discourse, however, does not establish the same level of emotional connection or interactivity with audiences as some other recent movements have, but these limitations can be partly explained by the unique political, material, and rhetorical constraints of the situation.

  19. Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus.

    Science.gov (United States)

    Dancer, S J; Kirkpatrick, P; Corcoran, D S; Christison, F; Farmer, D; Robertson, C

    2013-02-01

    A restrictive antibiotic policy banning routine use of ceftriaxone and ciprofloxacin was implemented in a 450-bed district general hospital following an educational campaign. Monthly consumption of nine antibiotics was monitored in defined daily doses (DDDs) per 1000 patient-occupied bed-days (1000 pt-bds) 9 months before until 16 months after policy introduction. Hospital-acquired Clostridium difficile, meticillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase (ESBL)-producing coliform cases per month/1000 pt-bds were identified and reviewed throughout the hospital. Between the first and final 6 months of the study, average monthly consumption of ceftriaxone reduced by 95% (from 46.213 to 2.129 DDDs/1000 pt-bds) and that for ciprofloxacin by 72.5% (109.804 to 30.205 DDDs/1000 pt-bds). Over the same periods, hospital-acquisition rates for C. difficile reduced by 77% (2.398 to 0.549 cases/1000 pt-bds), for MRSA by 25% (1.187 to 0.894 cases/1000 pt-bds) and for ESBL-producing coliforms by 17% (1.480 to 1.224 cases/1000 pt-bds). Time-lag modelling confirmed significant associations between ceftriaxone and C. difficile cases at 1 month (correlation 0.83; Pcoliform cases at 2 months (correlation 0.649; P=0.002). An audit performed 3 years after the policy showed sustained reduction in C. difficile rates (0.259 cases/1000 pt-bds), with additional decreases for MRSA (0.409 cases/1000 pt-bds) and ESBL-producing coliforms (0.809 cases/1000 pt-bds). In conclusion, banning two antibiotics resulted in an immediate and profound reduction in hospital-acquired C. difficile, with possible longer-term effects on MRSA and ESBL-producing coliform rates. Antibiotic stewardship is fundamental in the control of major hospital pathogens. Copyright © 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

  20. Cell-baswd non-invasive prenatal testing

    DEFF Research Database (Denmark)

    Uldbjerg, Niels; Singh, Ripudaman; Christensen, Rikke

    CONTROL ID: 2520273 ABSTRACT FINAL ID: OC06.03 TITLE: Cell based Non-invasive Prenatal Testing (NIPT) AUTHORS (FIRST NAME, LAST NAME): Niels Uldbjerg2, Ripudaman Singh4, Rikke Christensen3, Palle Schelde4, Ida Vogel1, Else Marie Vestergaard3, Lotte Hatt4, Steen Kølvrå4 INSTITUTIONS (ALL): 1...

  1. Molecular cloning and characteristic analysis of a thioredoxin from ...

    African Journals Online (AJOL)

    user

    2012-04-12

    Apr 12, 2012 ... protein molecules and damage their functions (Roos and. Messens, 2011). Thioredoxin (Trx), a hydrogen-carrying .... to PVDF (Pall, NY, USA). Membranes were blocked for 1 h in a. 10% non-fat dry ..... thioredoxin participates in the thermal stress induced redox change. Thioredoxin possesses a general ...

  2. Proposal to conserve Tamarix ramosissima against T. pentandra Tamaricaceae)

    Science.gov (United States)

    Ledebour described Tamarix ramosissima in 1829 from plants collected in Kazakhstan (Lake Noor Zaisan). In the protologue he overlooked T. pentandra Pall. (l.c.) and T. pallasii Desv. (l.c.), two earlier names which apply to the same biological entity, also widespread through Central and Western Asia...

  3. 78 FR 61392 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2013-10-03

    ..., Hartford, CT. Inc., Corporate/Finance/ Controllers. The following determinations terminating investigations... Staffing, Employee Management, CBS Personnel, etc. 82,977 Pall Corporation, Finance Port Washington, NY..., Greensboro, NC. Finance Department, Novartis AG, ProUnlimited. 82,984 The Berry Company, LLC Rochester, NY...

  4. A Study On The Acute Toxicological Effects Of Commercial Diesel ...

    African Journals Online (AJOL)

    Four doses (65/kg; 87 g/kg; 209; g/kg; 131 g/kg) of diesel fuel were administered intraperitoneally, into the rats and the effect monitored within 24hours. The following hematological parameters ( Haemoglobin concentration, palled cell volume, white blood cell count) and enzyme (Aspartate/ alamine aminotransferases and ...

  5. Kontseptuaalne ja liikumispõhine nüüdistants Täiskuu tantsufestivalil Soomes / Evelin Lagle

    Index Scriptorium Estoniae

    Lagle, Evelin, 1986-

    2010-01-01

    Tantsufestivalist "Täudenkuun Tanssit" (Full Moon Dance Festival). Tantsulavastustest - Tommi Kitti "Riff", Jyrki Karttuneni "Situation Room", Kenneth Kvanströmi "Destruction Song", Liisa Petti "Mabel or the Gueen of Bones", Elina Pirineni "A Friend of the Pianist", Johanna Tuukkaneni "Outstanding Performance" ja Palle Granhoj sooloetendus "(...It's a Very Big Secret...)"

  6. Väikeste ridamajade rida Kloostrimetsas = A Row of Little Row Houses in Kloostrimetsa / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2003-01-01

    Neljast ridaelamust, millest kaks on propjekteerinud Ado Eigi (Ado Eigi Arhitektuuribüroo, konstruktsioonid: Uno Pall, projekt 2002, valminud 2003), ühe Ott Kadarik ja Mihkel Tüür (COO Arhitektid, projekt 2002, valminud 2003) ning ühe arhitektuuribüroo Kosmos (valminud 2004). Sisevaade, 6 välisvaadet, 5 korruste plaani

  7. Validation of a real-time PCR based method for detection of Clostridium botulinum types C, D and their mosaic variants C-D and D-C in a multicenter collaborative trial

    DEFF Research Database (Denmark)

    Woudstra, C.; Skarin, H.; Anniballi, F.

    2013-01-01

    Two real-time PCR arrays based on the GeneDisc® cycler platform (Pall-GeneDisc Technologies) were evaluated in a multicenter collaborative trial for their capacity to specifically detect and discriminate Clostridium botulinum types C, D and their mosaic variants C-D and D-C that are associated wi...

  8. Technology Strategy Integration

    Science.gov (United States)

    2012-06-01

    calculated use of the media to incite an outcry for additional naval resources.163 The Pall Mall Gazette obliged, releasing an article entitled “The...widespread dissemination of professional articles which could have increased familiarity. 512...supporting air coverage, but this approach was discounted.796 However, the chosen strategy was too heavy to minimize the amount of gratuitous

  9. Seasonal and spatial root biomass and water use efficiency of four ...

    African Journals Online (AJOL)

    SERVER

    2007-12-03

    Dec 3, 2007 ... A field study was conducted to determine seasonal root biomass, root spatial distribution and water use efficiency (WUE) in milkvetch (Astragalus adsurgens Pall.), sainfoin (Onobrychis viciaefolia Scop.), alfalfa (Medicago sativa L.) and Lespedeza davurica (L. davurica) grown in semiarid region on the ...

  10. The role of environmental shocks in shaping prosocial behavior

    NARCIS (Netherlands)

    Duchoslav, Jan

    2017-01-01

    <p>All economic activity requires some degree of cooperation, and the process of economic development involves many social dilemmas. It is therefore crucial to understand how the preferences which guide our behavior vis-à-vis these situations are shaped. The ability and willingness to work for the

  11. Inhibition of Lipopolysaccharide-Stimulated Neuro- Inflammatory ...

    African Journals Online (AJOL)

    Purpose: To investigate the in vitro antioxidant and anti-neuroinflammatory effects of Tetragonia tetragonoides (Pall.) Kuntze extract (TKE) in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Methods: To evaluate the effects of TKE, LPS-stimulated BV microglia were used and the expression and production of ...

  12. Validation of a real-time PCR based method for detection of Clostridium botulinum types C, D and their mosaic variants C-D and D-C in a multicenter collaborative trial

    NARCIS (Netherlands)

    Woudstra, C.; Skarin, H.; Anniballi, F.; Auricchio, B.; Medici, De D.; Bano, L.; Drigo, I.; Hansen, T.; Löfström, Ch.; Hamidjaja, R.; Rotterdam, van B.; Koene, M.G.J.

    2013-01-01

    Two real-time PCR arrays based on the GeneDisc(®) cycler platform (Pall-GeneDisc Technologies) were evaluated in a multicenter collaborative trial for their capacity to specifically detect and discriminate Clostridium botulinum types C, D and their mosaic variants C-D and D-C that are associated

  13. Neurotoxin gene profiling of Clostridium botulinum types C and D gathered from different countries within Europe

    NARCIS (Netherlands)

    Woudstra, C.; Skarin, A.; Anniballi, F.; Fenicia, F.; Bano, L.; Drigo, I.; Koene, M.G.J.; Bäyon-Auboyer, M.H.; Buffereau, J.P.; Medici, D.; Fach, P.

    2012-01-01

    Clostridium botulinum types C and D, as well as their mosaic variants C-D and D-C, are associated with avian and mammalian botulism. This study reports on the development of low-density macroarrays based on the GeneDisc cycler platform (Pall-GeneDisc Technologies) applied to the simultaneous

  14. The Model

    DEFF Research Database (Denmark)

    About the reconstruction of Palle Nielsen's (f. 1942) work The Model from 1968: a gigantic playground for children in the museum, where they can freely romp about, climb in ropes, crawl on wooden structures, work with tools, jump in foam rubber, paint with finger paints and dress up in costumes....

  15. The Shock and Vibration Digest. Volume 17, Number 4

    Science.gov (United States)

    1985-04-01

    Hailer rekonstruktion) Institut f. Maschinenkonstruktionalehre, A. Bayati, M. Henle Universitat Karlsruhe, Kaiserstr. 12, D-7500 Siemens AG E STE 212...755 Luongo, A....................... 728 Heidari, M.A................... 847 Lyons, J.A..................... 695 * Henle , M...City, PA (ASME) 4-8 Acoustical Society of America, Pall Meeting CASA] Nashville, TN ( ASA ) S-10 Lubrication Conference [ASLE/- ASME] Atlanta, GA (ASLE

  16. Fulltext PDF

    Indian Academy of Sciences (India)

    Pope wrote Newton's epitaph when he died: "Nature and Nature's laws lay hid by night: God said Let Newton be! and all was light." Newton was buried in Westminster Abbey. The pall bearers to this farmer's son were three earls, two dukes, and the Lord Chancellor; they were followed by the Fellows of the Royal Society.

  17. In vitro antioxidant activity and inhibitory hepatic steatosis effect on ...

    African Journals Online (AJOL)

    The nutrient and phytochemical composition of Rosa davurica Pall. fruit (RDF) from China were determined, including sugar, reducing sugar, ascorbic acid, caroteniods and phenolics. RDF was successively extracted with chloroform, ethyl acetate (EA), water-saturated n-butanol, ethanol and distilled water, respectively.

  18. RESONANCEI

    Indian Academy of Sciences (India)

    Newton was buried in Westminster Abbey. The pall bearers to this farmer's son were three earls, two dukes, and the Lord Chancellor; they were followed by the Fellows of the Royal Society. The rather elaborate monument at his grave bears the inscription. "Hic depositum est, quod mortale fuit Isaaci Newtoni." The immortal ...

  19. Eestlaste pension kinnisvaraturu meelevallas / Anne Oja

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti 22. aug. lk. 6. Eesti pensionifondid on kinnisvarasse paigutanud umbes miljard krooni. Kinnisvarafirmade võlakirjade hind võib kujuneda madalaks. Pankade kommentaarid. Vt. samas: Tulevased pensionärid magavad rahulikult. Tabel: Pensionifondide investeeringud kinnisvarasse. Kommenteerivad: Ingmar Mattus, Kalle Palling, Karoli Hindriks, Pertti Rahnel, Andre Nõmm, Urmas Laur, Kristjan Lepik. Kommentaarid ainult eestikeelse art. juures

  20. Late quaternary evolution of the Meuse fluvial system and its sediment composition : a reconstruction based on bulk sample geochemistry and forward modelling

    NARCIS (Netherlands)

    Tebbens, L.A.

    1999-01-01

    <p>All fluvial systems ultimately drain into alluvial basins, where the weathering products of their upstream drainage areas accumulate over a time-span varying from 10 0to 10 6years. Most silted-up alluvial basins are low-gradient deltas that are

  1. Pacific Armies Management Seminar IV Held at Honolulu, Hawaii, on 3-7 November 1980.

    Science.gov (United States)

    1980-11-07

    Donn A. Starry General Wolff, distinguished guests, ladles and gentlemen. The fact that many in this room traveled over 6,000 miles to come to this...most people did not take the time to understand the organization and actions of Groupernent Mobile 100, its fate cast a pall over armored operations in

  2. Effects of drought and salt stress on seed germination of three ...

    African Journals Online (AJOL)

    The seeds of Medicago sativa (L.), Astragalus adsurgens (Pall.) and Coronilla varia (L.) were evaluated at germination for tolerance to salt (NaCl) and drought conditions induced by polyethylene glycol (PEG) in an experiment of orthogonal design. The results reveal that the germination percentages of M. sativa and A.

  3. Using natural variation to unravel the dynamic regulation of plant performance in diverse environments

    NARCIS (Netherlands)

    Molenaar, J.A.

    2015-01-01

    Summary

    <p>All plants are able to respond to changes in their environment by adjusting their morphology and metabolism, but large differences are observed in the effectiveness of these responses in the light of plant fitness. Between and within species large differences are

  4. Eesti Energia nõukogu liikmed Jaotusvõrgu hinnatõusutaotlust kommenteerima ei kipu / Katre Pilvinski

    Index Scriptorium Estoniae

    Pilvinski, Katre

    2010-01-01

    Eesti Energia nõukogu liige Kalle Palling kommenteerib peaminister Andrus Ansipi öeldut, et Eesti Energia investeeringud tuleb üle vaadata. Nõukogu liikme Rein Kilgi sõnul tunduvad talle rünnakud Eesti Energia vastu ülekohtused

  5. Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma.

    Science.gov (United States)

    Porter, Elizabeth G; Dykhuizen, Emily C

    2017-02-17

    The architecture of chromatin is governed, in part, by ATP-dependent chromatin remodelers. These multiprotein complexes contain targeting domains that recognize post-translational marks on histones. One such targeting domain is the bromodomain (BD), which recognizes acetyl-lysines and recruits proteins to sites of acetylation across the genome. Polybromo1 (PBRM1), a subunit of the Polybromo-associated BRG1- or hBRM-associated factors (PBAF) chromatin remodeler, contains six tandem BDs and is frequently mutated in clear cell renal cell carcinoma (ccRCC). Mutations in the PBRM1 gene often lead to the loss of protein expression; however, missense mutations in PBRM1 have been identified and tend to cluster in the BDs, particularly BD2 and BD4, suggesting that individual BDs are critical for PBRM1 function. To study the role of these six BDs, we inactivated each of the six BDs of PBRM1 and re-expressed these mutants in Caki2 cells (ccRCC cells with the loss of function mutation in PBRM1 ). Four of the six BDs abrogated PBRM1 tumor suppressor function, gene regulation, and chromatin affinity with the degree of importance correlating strongly to the rate of missense mutations in patients. Furthermore, we identified BD2 as the most critical for PBRM1 and confirmed BD2-mediated association to histone H3 peptides acetylated at lysine 14 (H3K14Ac), validating the importance of this specific acetylation mark for PBRM1 binding. From these data, we conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  6. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.

    Science.gov (United States)

    De Petrocellis, Luciano; Ligresti, Alessia; Moriello, Aniello Schiano; Allarà, Marco; Bisogno, Tiziana; Petrosino, Stefania; Stott, Colin G; Di Marzo, Vincenzo

    2011-08-01

    Cannabidiol (CBD) and Δ(9) -tetrahydrocannabinol (THC) interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system. The effects of 11 pure cannabinoids and botanical extracts [botanical drug substance (BDS)] from Cannabis varieties selected to contain a more abundant cannabinoid, on TRPV1, TRPV2, TRPM8, TRPA1, human recombinant diacylglycerol lipase α (DAGLα), rat brain fatty acid amide hydrolase (FAAH), COS cell monoacylglycerol lipase (MAGL), human recombinant N-acylethanolamine acid amide hydrolase (NAAA) and anandamide cellular uptake (ACU) by RBL-2H3 cells, were studied using fluorescence-based calcium assays in transfected cells and radiolabelled substrate-based enzymatic assays. Cannabinol (CBN), cannabichromene (CBC), the acids (CBDA, CBGA, THCA) and propyl homologues (CBDV, CBGV, THCV) of CBD, cannabigerol (CBG) and THC, and tetrahydrocannabivarin acid (THCVA) were also tested. CBD, CBG, CBGV and THCV stimulated and desensitized human TRPV1. CBC, CBD and CBN were potent rat TRPA1 agonists and desensitizers, but THCV-BDS was the most potent compound at this target. CBG-BDS and THCV-BDS were the most potent rat TRPM8 antagonists. All non-acid cannabinoids, except CBC and CBN, potently activated and desensitized rat TRPV2. CBDV and all the acids inhibited DAGLα. Some BDS, but not the pure compounds, inhibited MAGL. CBD was the only compound to inhibit FAAH, whereas the BDS of CBC > CBG > CBGV inhibited NAAA. CBC = CBG > CBD inhibited ACU, as did the BDS of THCVA, CBGV, CBDA and THCA, but the latter extracts were more potent inhibitors. These results are relevant to the analgesic, anti-inflammatory and anti-cancer effects of cannabinoids and Cannabis extracts. © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

  7. Multiple somatic symptoms in primary care patients: a cross-sectional study of consultation content, clinical management strategy and burden of encounter.

    Science.gov (United States)

    Rask, Mette T; Carlsen, Anders H; Budtz-Lilly, Anna; Rosendal, Marianne

    2016-07-30

    Consultations involving patients with multiple somatic symptoms may be considered as challenging and time-consuming by general practitioners (GPs). Yet, little is known about the possible links between consultation characteristics and GP-experienced burden of encounter. We aimed to explore consultation content, clinical management strategies, time consumption and GP-experienced burden of encounters with patients suffering from multiple somatic symptoms as defined by the concept of bodily distress syndrome (BDS). Cross-sectional study of patient encounters in primary care from December 2008 to December 2009; 387 GPs participated (response rate: 44.4 %). Data were based on a one-page registration form completed by the GP and a patient questionnaire including the 25-item BDS checklist for somatic symptoms. Using logistic regression analyses, we compared patients who met the BDS criteria with patients who did not. A total of 1505 patients were included (response rate: 55.6 %). Health problems were less frequently reported as 'new' in patients with BDS (odds ratio (OR) = 0.73, 95 % confidence interval (CI): 0.54; 0.97). Medical prescriptions and referral rates were comparable in the two patient groups. Consultations focusing on mainly biomedical aspects were less frequent among patients with BDS (OR = 0.31, 95 % CI: 0.22; 0.43), whereas additional biomedical and psychosocial problems were more often discussed. GPs were more likely to ensure continuity of care in BDS patients by watchful waiting strategies (OR = 2.32, 95 % CI: 1.53; 3.52) or scheduled follow-up visits (OR = 1.61, 95 % CI: 1.09; 2.37). Patients with BDS were found to be more time-consuming (OR = 1.77, 95 % CI: 1.26; 2.48) and burdensome (OR = 2.54, 95 % CI: 1.81; 3.55) than patients without BDS. However, after adjustments for biomedical and psychosocial content of the consultation, the identified differences for time consumption and burden were no longer statistically

  8. Microbial phytase addition resulted in a greater increase in phosphorus digestibility in dry-fed compared with liquid-fed non-heat-treated wheat-barley-maize diets for pigs.

    Science.gov (United States)

    Blaabjerg, K; Thomassen, A-M; Poulsen, H D

    2015-02-01

    The objective was to evaluate the effect of microbial phytase (1250 FTU/kg diet with 88% dry matter (DM)) on apparent total tract digestibility (ATTD) of phosphorus (P) in pigs fed a dry or soaked diet. Twenty-four pigs (65±3 kg) from six litters were used. Pigs were housed in metabolism crates and fed one of four diets for 12 days; 5 days for adaptation and 7 days for total, but separate collection of feces and urine. The basal diet was composed of wheat, barley, maize, soybean meal and no mineral phosphate. Dietary treatments were: basal dry-fed diet (BDD), BDD with microbial phytase (BDD+phy), BDD soaked for 24 h at 20°C before feeding (BDS) and BDS with microbial phytase (BDS+phy). Supplementation of microbial phytase increased ATTD of DM and crude protein (N×6.25) by 2 and 3 percentage units (P<0.0001; P<0.001), respectively. The ATTD of P was affected by the interaction between microbial phytase and soaking (P=0.02). This was due to a greater increase in ATTD of P by soaking of the diet containing solely plant phytase compared with the diet supplemented with microbial phytase: 35%, 65%, 44% and 68% for BDD, BDD+phy, BSD and BSD+phy, respectively. As such, supplementation of microbial phytase increased ATTD of P in the dry-fed diet, but not in the soaked diet. The higher ATTD of P for BDS compared with BDD resulted from the degradation of 54% of the phytate in BDS by wheat and barley phytases during soaking. On the other hand, soaking of BDS+phy did not increase ATTD of P significantly compared with BDD+phy despite that 76% of the phytate in BDS+phy was degraded before feeding. In conclusion, soaking of BDS containing solely plant phytase provided a great potential for increasing ATTD of P. However, this potential was not present when microbial phytase (1250 FTU/kg diet) was supplemented, most likely because soaking of BDS+phy for 24 h at 20°C did not result in a complete degradation of phytate before feeding.

  9. Bulk magnetic domain stability controls paleointensity fidelity

    Science.gov (United States)

    Paterson, Greig A.; Muxworthy, Adrian R.; Yamamoto, Yuhji; Pan, Yongxin

    2017-12-01

    Nonideal, nonsingle-domain magnetic grains are ubiquitous in rocks; however, they can have a detrimental impact on the fidelity of paleomagnetic records—in particular the determination of ancient magnetic field strength (paleointensity), a key means of understanding the evolution of the earliest geodynamo and the formation of the solar system. As a consequence, great effort has been expended to link rock magnetic behavior to paleointensity results, but with little quantitative success. Using the most comprehensive rock magnetic and paleointensity data compilations, we quantify a stability trend in hysteresis data that characterizes the bulk domain stability (BDS) of the magnetic carriers in a paleomagnetic specimen. This trend is evident in both geological and archeological materials that are typically used to obtain paleointensity data and is therefore pervasive throughout most paleomagnetic studies. Comparing this trend to paleointensity data from both laboratory and historical experiments reveals a quantitative relationship between BDS and paleointensity behavior. Specimens that have lower BDS values display higher curvature on the paleointensity analysis plot, which leads to more inaccurate results. In-field quantification of BDS therefore reflects low-field bulk remanence stability. Rapid hysteresis measurements can be used to provide a powerful quantitative method for preselecting paleointensity specimens and postanalyzing previous studies, further improving our ability to select high-fidelity recordings of ancient magnetic fields. BDS analyses will enhance our ability to understand the evolution of the geodynamo and can help in understanding many fundamental Earth and planetary science questions that remain shrouded in controversy.

  10. Dynamics of Subarcsecond Bright Dots in the Transition Region above Sunspots and Their Relation to Penumbral Micro-jets

    Energy Technology Data Exchange (ETDEWEB)

    Samanta, Tanmoy; Banerjee, Dipankar [Indian Institute of Astrophysics, Koramangala, Bangalore 560034 (India); Tian, Hui [School of Earth and Space Sciences, Peking University (China); Schanche, Nicole, E-mail: tsamanta@iiap.res.in, E-mail: huitian@pku.edu.cn, E-mail: dipu@iiap.res.in, E-mail: ns81@st-andrews.ac.uk [University of St. Andrews, St. Andrews (United Kingdom)

    2017-02-01

    Recent high-resolution observations have revealed that subarcsecond bright dots (BDs) with sub-minute lifetimes appear ubiquitously in the transition region (TR) above sunspot penumbra. The presence of penumbral micro-jets (PMJs) in the chromosphere was previously reported. It was proposed that both the PMJs and BDs are formed due to a magnetic reconnection process and may play an important role in heating of the penumbra. Using simultaneous observations of the chromosphere from the Solar Optical Telescope (SOT) on board Hinode and observations of the TR from the Interface Region Imaging Spectrograph , we study the dynamics of BDs and their relation to PMJs. We find two types of BDs, one that is related to PMJs, and another that does not show any visible dynamics in the SOT Ca ii H images. From a statistical analysis we show that these two types have different properties. The BDs that are related to PMJs always appear at the top of the PMJs, the vast majority of which show inward motion and originate before the generation of the PMJs. These results may indicate that the reconnection occurs at the lower coronal/TR height and initiates PMJs at the chromosphere. This formation mechanism is in contrast with the formation of PMJs by reconnection in the (upper) photosphere between differently inclined fields.

  11. A CONCEPTUAL TRAJECTORY MULTIDIMENSIONAL MODEL: AN APPLICATION TO PUBLIC TRANSPORTATION

    Directory of Open Access Journals (Sweden)

    FRANCISCO MORENO

    2011-01-01

    Full Text Available Actualmente, gracias a tecnologías como los sistemas de posicionamiento global y dispositivos móviles provistos de sensores, se puede recopilar una gran cantidad de datos sobre objetos móviles, e.g., datos relacionados con la trayectoria seguida por estos objetos. Por otra parte, las Bodegas de Datos (BDs, usualmente modeladas mediante una vista multidimensional de los datos, son bases de datos especializadas para ayudar en la toma de decisiones. Desafortunadamente, las BDs convencionales ofrecen poco soporte para la gestión de trayectorias. Aunque existen algunas propuestas que tratan con BDs de trayectorias, ninguna de ellas se enfoca en su modelamiento conceptual multidimensional. En este artículo se extiende un modelo conceptual multidimensional espacial donde se incorporan las trayectorias como conceptos de primera clase. Con el fi n de mostrar la conveniencia de la propuesta, se presenta un ejemplo relacionado con transporte público.

  12. Preparation of Bulk Na{sub 2}O-BaO-PbO-Nb{sub 2}O{sub 5}-SiO{sub 2} Glass-Ceramic Dielectrics for Energy Storage Sources

    Energy Technology Data Exchange (ETDEWEB)

    Luo Jun; Tang Qun; Zhang Qingmeng; Zhu Jun; Han Dongfang; Du Jun, E-mail: luojun@griaem.com, E-mail: dujun@grinm.com [Advanced Electronic Materials Institute, General Research Institute for Nonferrous Metals, Beijing 100088 (China)

    2011-10-29

    Bulk Na{sub 2}O-BaO-PbO-Nb{sub 2}O{sub 5}-SiO{sub 2} glass-ceramic dielectrics in considerable size (about 200x100x5mm{sup 3}) were prepared via controlled-crystallization route. The dielectric properties (including the permittivity and the loss tangent) of the bulk dielectrics were investigated. The results show that the capability of charge or energy storage in the bulk dielectrics is relatively lower than that of anticipation based on thinner and smaller specimen, due to the serious breakdown strength (BDS) drop of the bulk dielectrics. Several electrode structures were designed and applied in the measurement circuit to enhance the BDS of the bulk dielectrics. Among which, a bowl-like electrode structure was proved to reduce electrode edge effect most effectively in the BDS measurement.

  13. MULTI-WAVELENGTH STUDY OF TRANSITION REGION PENUMBRAL SUBARCSECOND BRIGHT DOTS USING IRIS AND NST

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Na; Liu, Chang; Xu, Yan; Wang, Haimin [Space Weather Research Laboratory, New Jersey Institute of Technology, University Heights, Newark, NJ 07102-1982 (United States); Yurchyshyn, Vasyl [Big Bear Solar Observatory, New Jersey Institute of Technology, 40386 North Shore Lane, Big Bear City, CA 92314-9672 (United States); Tian, Hui [School of Earth and Space Sciences, Peking University, Beijing, 100871 (China); Kleint, Lucia, E-mail: na.deng@njit.edu [University of Applied Sciences and Arts Northwestern Switzerland, Bahnhofstr. 6, 5210 Windisch (Switzerland)

    2016-10-01

    Using high-resolution transition region (TR) observations taken by the Interface Region Imaging Spectrograph ( IRIS ) mission, Tian et al. revealed numerous short-lived subarcsecond bright dots (BDs) above sunspots (mostly located in the penumbrae), which indicate yet unexplained small-scale energy releases. Moreover, whether or not these subarcsecond TR brightenings have any signature in the lower atmosphere and how they are formed are still not fully resolved. This paper presents a multi-wavelength study of the TR penumbral BDs using a coordinated observation of a near disk center sunspot with IRIS and the 1.6 m New Solar Telescope (NST) at the Big Bear Solar Observatory. NST provides high-resolution chromospheric and photospheric observations with narrowband H α imaging spectroscopy and broadband TiO images, respectively, complementary to IRIS TR observations. A total of 2692 TR penumbral BDs are identified from a 37 minute time series of IRIS 1400 Å slit-jaw images. Their locations tend to be associated more with downflowing and darker fibrils in the chromosphere, and weakly associated with bright penumbral features in the photosphere. However, temporal evolution analyses of the BDs show that there is no consistent and convincing brightening response in the chromosphere. These results are compatible with a formation mechanism of the TR penumbral BDs by falling plasma from coronal heights along more vertical and dense magnetic loops. The BDs may also be produced by small-scale impulsive magnetic reconnection taking place sufficiently high in the atmosphere that has no energy release in the chromosphere.

  14. The evaluation of an approach to reflective learning in the undergraduate dental curriculum.

    Science.gov (United States)

    Bush, H; Bissell, V

    2008-05-01

    Students in higher education are being encouraged to become active, independent and life-long learners. The use of progress files has been endorsed to encourage this approach. A portfolio intended to fulfil the role of a progress file and to promote student-centred learning and reflection was introduced as a central component of the revised undergraduate degree at the Glasgow Dental School in 2004. This article evaluates its role in promoting reflection. Students following the Bachelor of Dental Surgery (BDS) programme completed three written reflections per year using structured proformas, and discussed them with their mentor and mentoring group. Their views of the portfolio and of reflection were gathered using a five-point Likert scale. In BDS1 2004-5, 84% completed a questionnaire, as did 89% in BDS1 2005-6 and 99% in BDS2 2005-6. Most students did not enjoy reflecting (a finding commonly reported elsewhere) or feel that reflection identified their learning needs. It appears that students disliked writing reflections, rather than reflecting per se. In contrast, they took a positive view of mentor group discussions and of having a mentor, both essential components of the portfolio model described. Comparisons of BDS1 2004-5 and BDS2 2005-6 data suggest that students are becoming more comfortable with reflection. The data provide some limited encouragement that students are beginning to acquire the skills which will enable them to reflect purposefully in their professional lives, although it will be some years before this assertion can be substantiated.

  15. Transcriptional profiling avian beta-defensins in chicken oviduct epithelial cells before and after infection with Salmonella enterica serovar Enteritidis

    Directory of Open Access Journals (Sweden)

    Bailey R Hartford

    2009-07-01

    Full Text Available Abstract Background Salmonella enterica serovar Enteritidis (SE colonizes the ovary and oviduct of chickens without causing overt clinical signs which can lead to SE-contamination of the content and membrane of shell-eggs as well as hatchery eggs. The organism utilizes the Salmonella Pathogenicity Island-2 encoded type III secretion system (T3SS-2 to promote persistence in the oviduct of laying hens. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR was carried out to determine the expression profiles of 14 known avian beta defensins (AvBDs in primary chicken oviduct epithelial cells (COEC before and after infections with a wild type SE strain and T3SS mutant SE strains carrying an inactivated sipA or pipB gene. Results Based on the expression levels in uninfected COEC, AvBDs can be loosely grouped into three categories with AvBD4-5 and AvBD9-12 being constitutively expressed at high levels; AvBD1, AvBD3, and AvBD13-14 at moderate levels; and AvBD2 and AvBD6-8 at minimal levels. Infection with the wild type SE strain temporarily repressed certain highly expressed AvBDs and induced the expression of minimally expressed AvBDs. The pipB mutant, compared to the wild type strain, had reduced suppressive effect on the expression of highly expressed AvBDs. Moreover, the pipB mutant elicited significantly higher levels of the minimally expressed AvBDs than the wild type SE or the sipA mutant did. Conclusion Chicken oviduct epithelial cells express most of the known AvBD genes in response to SE infection. PipB, a T3SS-2 effector protein, plays a role in dampening the β-defensin arm of innate immunity during SE invasion of chicken oviduct epithelium.

  16. Transcriptional profiling avian beta-defensins in chicken oviduct epithelial cells before and after infection with Salmonella enterica serovar Enteritidis.

    Science.gov (United States)

    Ebers, Katie L; Zhang, C Yan; Zhang, M Zhenyu; Bailey, R Hartford; Zhang, Shuping

    2009-07-30

    Salmonella enterica serovar Enteritidis (SE) colonizes the ovary and oviduct of chickens without causing overt clinical signs which can lead to SE-contamination of the content and membrane of shell-eggs as well as hatchery eggs. The organism utilizes the Salmonella Pathogenicity Island-2 encoded type III secretion system (T3SS-2) to promote persistence in the oviduct of laying hens. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was carried out to determine the expression profiles of 14 known avian beta defensins (AvBDs) in primary chicken oviduct epithelial cells (COEC) before and after infections with a wild type SE strain and T3SS mutant SE strains carrying an inactivated sipA or pipB gene. Based on the expression levels in uninfected COEC, AvBDs can be loosely grouped into three categories with AvBD4-5 and AvBD9-12 being constitutively expressed at high levels; AvBD1, AvBD3, and AvBD13-14 at moderate levels; and AvBD2 and AvBD6-8 at minimal levels. Infection with the wild type SE strain temporarily repressed certain highly expressed AvBDs and induced the expression of minimally expressed AvBDs. The pipB mutant, compared to the wild type strain, had reduced suppressive effect on the expression of highly expressed AvBDs. Moreover, the pipB mutant elicited significantly higher levels of the minimally expressed AvBDs than the wild type SE or the sipA mutant did. Chicken oviduct epithelial cells express most of the known AvBD genes in response to SE infection. PipB, a T3SS-2 effector protein, plays a role in dampening the beta-defensin arm of innate immunity during SE invasion of chicken oviduct epithelium.

  17. Microlensing discovery of a population of very tight, very low mass binary brown dwarfs

    DEFF Research Database (Denmark)

    Choi, J.-Y.; Han, C.; Udalski, A.

    2013-01-01

    Although many models have been proposed, the physical mechanisms responsible for the formation of low-mass brown dwarfs (BDs) are poorly understood. The multiplicity properties and minimum mass of the BD mass function provide critical empirical diagnostics of these mechanisms. We present the disc......Although many models have been proposed, the physical mechanisms responsible for the formation of low-mass brown dwarfs (BDs) are poorly understood. The multiplicity properties and minimum mass of the BD mass function provide critical empirical diagnostics of these mechanisms. We present...

  18. China Satellite Navigation Conference

    CERN Document Server

    Liu, Jingnan; Fan, Shiwei; Wang, Feixue

    2016-01-01

    These Proceedings present selected research papers from CSNC2016, held during 18th-20th May in Changsha, China. The theme of CSNC2016 is Smart Sensing, Smart Perception. These papers discuss the technologies and applications of the Global Navigation Satellite System (GNSS), and the latest progress made in the China BeiDou System (BDS) especially. They are divided into 12 topics to match the corresponding sessions in CSNC2016, which broadly covered key topics in GNSS. Readers can learn about the BDS and keep abreast of the latest advances in GNSS techniques and applications.

  19. Physical volcanology, geochemistry and basin evolution of the Ediacaran volcano-sedimentary succession in the Bas Draâ inlier (Ouarzazate Supergroup, Western Anti-Atlas, Morocco)

    Science.gov (United States)

    Karaoui, Brahim; Breitkreuz, Christoph; Mahmoudi, Abdelkader; Youbi, Nasrrddine

    2014-11-01

    New geologic mapping, lithofacies and granulometric analysis, and geochemistry from the volcano-sedimentary successions of the central part of the Bas Draâ inlier, Western Anti-Atlas, constrain the Ediacaran Ouarzazate Supergroup evolution during the post-collisional stage of the Pan-African orogeny. Volcanosedimentary facies analysis is the key aspect of the present contribution. We distinguished sixteen terrestrial volcanosedimentary lithofacies in the Bas Draâ succession (BDS), which reaches a total thickness of 2000 m. BDS evolution can be grouped into four units (Aouinet Aït Oussa I to IV, AO I-AO IV). The earliest volcanic activity produced rhyolitic ignimbrite sheets (AO I), which had been considered as lava flows by previous workers, and which were presumably related to caldera system(s). During AO II, a complex of high-silica andesitic and rhyolitic lavas formed, punctuated by the explosive eruption of a high-temperature silica-rich magma leading to the formation of parataxitic ignimbrite. AO III consists of basalt and andesite lava fields and small explosive, in parts phreatomagmatic volcanic vents. It is dissected by fluvial systems depositing external non-volcanic and local volcanic debris. BDS evolution terminated with the formation of a large SiO2-rich lava dome complex (AO IV), accompanied by small basalt effusive event. Volcanosedimentary facies analysis infers that the BDS evolved in a continental extensional setting developing in a low topography under humid paleoclimatic conditions. Alteration textures are dominated by a piemontite-calcite-albite-quartz (+ iron oxides) assemblage. Chemical analysis of BDS volcanic and subvolcanic rocks belongs to high-k calc-alkaline and alkali-calcic to alkaline magmatic trend typical for a post-collision setting. Trace elements spidergrams show a pattern typical for subduction-related suites of orogenic belts. REE patterns show moderate enrichment in LREE relative to flat HREE, with strong negative Eu

  20. Equilibrium studies of the adsorption of aromatic disulfonates by Mg-Al oxide

    Science.gov (United States)

    Kameda, Tomohito; Umetsu, Mami; Kumagai, Shogo; Yoshioka, Toshiaki

    2018-03-01

    The removal of m-benzenedisulfonate (BDS2-) and 2,6-naphthalenedisulfonate (NDS2-) anions by Mg-Al oxide was investigated. Langmuir model best describes the adsorption of both aromatic disulfonate anions, with the maximum amount of uptake higher for BDS2-. Mg-Al oxide reacts easier with the aromatic disulfonate anion with higher charge density, a trend that is the opposite of that observed in aromatic sulfonate anions. After increasing the charge from -1 to -2, the removal of aromatic disulfonates by Mg-Al oxide is controlled by electrostatic interactions, instead of hydrophobic interactions that are dominant for aromatic sulfonate anions.

  1. China Satellite Navigation Conference

    CERN Document Server

    Liu, Jingnan; Yang, Yuanxi; Fan, Shiwei; Yu, Wenxian

    2017-01-01

    These proceedings present selected research papers from CSNC2017, held during 23th-25th May in Shanghai, China. The theme of CSNC2017 is Positioning, Connecting All. These papers discuss the technologies and applications of the Global Navigation Satellite System (GNSS), and the latest progress made in the China BeiDou System (BDS) especially. They are divided into 12 topics to match the corresponding sessions in CSNC2017, which broadly covered key topics in GNSS. Readers can learn about the BDS and keep abreast of the latest advances in GNSS techniques and applications.

  2. MONEY TRANSFERS VIA ONLINE PLATFORMS - LOGISTICS FOR BUSINESS DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    CLAUDIA ISAC

    2016-10-01

    Full Text Available In this paper I have presented 3 of the money transfer platforms which operate via the Internet. The development of the Internet, electronic commerce and money transfers due to international migration and movement of people directly determines the improvement of money transfer processes, so as to find the best tools for money transfers at minimum costs and high transfer speeds, implying secure trading and personal data privacy. In this context I have compared the three most frequently used trading platforms PayPall, transferGo, TransferWise, also including a presentation of each of them. I have also done a more detailed analysis of the evolution of PayPall in Romania and on the international market due to the high amounts of money and the number of transactions. I have completed the work with a brief presentation of the financial trends and especially of trading via the Internet.

  3. Vegetation and Environmental Gradients of the Prudhoe Bay Region, Alaska,

    Science.gov (United States)

    1985-09-01

    alpine plants include Androsace chamaejasme ssp. and Asia. It also contains plants just reaching lehmanniana, Carex aquatilis, Valeriana capitata...of the river (Figure Al, points 6, 38, 42, 43, 48). Valeriana capitata Pall. D. Murray 4551. Occasional; moist to wet stream sides. Wilhelmsia... VALERIANA CAPITATA ARCTIC - ALPINE NORTH AMERICA, ASIA ZONE 2 C. AILHELMSIA PHYSOOES ARCTIC NORTH AMERICA. ASIA ZONE 3 . ,% 237 % 44 -- a 0R M M ,WU I W RO n

  4. [Enrichment process of gentiopicroside from the leaves of Gentiana macropylla with macroporous resin].

    Science.gov (United States)

    Zhao, Yong; Zhang, Ru; Sun, Wen-ji

    2007-12-01

    To select the best type of macroporous resin for enriching gentiopicroside from the leaves of Gentiana macropylla, and study its optimal conditions and parameters. Adsorption and desorption characteristics of gentiopieroside were carried out on the resins. HPLC was used to determine the content of gentiopieroside. The better resin D-101 was chosen, and the optimal parameters were obtained. The process is feasible to enrich gentiopicroside from the leaves of Gentiana macropylla Pall.

  5. Maritime Claims Reference Manual.

    Science.gov (United States)

    1997-01-01

    Orinoco River . A Point, west of the middle of the line, is situated approximately 22 nautical miles from the nearest mainland. In contrast, the principal...running from Rodon Cape (Muzhli), Palle Cape, Lagji Cape (Turra Castle), Seman Cape, the Josa River estuary, the north-eastern shore of Sazan Island...territorial waters from the Buna River estuary to Rodon Cape is extended up to the Albanian-Yugoslavian border line." Article 2 - This decree enters into

  6. Quantitative Proteomics Analysis of Herbaceous Peony in Response to Paclobutrazol Inhibition of Lateral Branching

    OpenAIRE

    Zhao, Daqiu; Gong, Saijie; Hao, Zhaojun; Meng, Jiasong; Tao, Jun

    2015-01-01

    Herbaceous peony (Paeonia lactiflora Pall.) is an emerging high-grade cut flower worldwide, which is usually used in wedding bouquets and known as the “wedding flower”. However, abundant lateral branches appear frequently in some excellent cultivars, and a lack of a method to remove Paeonia lactiflora lateral branches other than inefficient artificial methods is an obstacle for improving the quality of its cut flowers. In this study, paclobutrazol (PBZ) application was found to inhibit the gr...

  7. 1855-IJBCS-Article-Omotoso Olaiya

    African Journals Online (AJOL)

    hp

    This study was designed to determine the effects of cigarette smoke on the body weights of Wistar rats, anti-oxidant activity and the histology of the frontal cortex. Sixteen Wistar rats with mean weight of 131.40 ±. 4.43 g were used. They were grouped into four. Group A had a stick of cigarette (Pall Mall brand ®) daily, group B ...

  8. Näitused kunstiakadeemias

    Index Scriptorium Estoniae

    2003-01-01

    EKA galeriis näitusel "Kirju pall" esitavad "krutskilist ökokunsti" rühmitus Puhas Rõõm, Mart Viljus, Anu Vahtra, Maris Mändel, Katrin Tees, Reimo Võsa-Tangsoo, Erki Kasemets, Raivo Hool. Aula fuajees näeb Jaak Soansi juhendamisel valminud skulptuuriosakonna õppetöid, valdavalt poliitikute skulptuurportreid. Osalevad Kristiina Järvelaid, Jelena Levtshenkova, Rene Reinumäe, Kaisa Uusoksa, Marju Vaher

  9. Exposure to cigarette smoke altered the cytoarchitecture and anti ...

    African Journals Online (AJOL)

    This study was designed to determine the effects of cigarette smoke on the body weights of Wistar rats, anti-oxidant activity and the histology of the frontal cortex. Sixteen Wistar rats with mean weight of 131.40 ± 4.43 g were used. They were grouped into four. Group A had a stick of cigarette (Pall Mall brand ®) daily, group B ...

  10. Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Amanda [Pall Corporation, Port Washington, NY (United States); Zhao, Hongbin [Pall Corporation, Port Washington, NY (United States); Hopkins, Scott [Pall Corporation, Port Washington, NY (United States)

    2014-12-01

    This report summarizes the work completed under the U.S. Department of Energy Project Award No.: DE-FE0001181 titled “Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods.” The project started in October 1, 2009 and was finished September 30, 2014. Pall Corporation worked with Cornell University to sputter and test palladium-based ternary alloys onto silicon wafers to examine many alloys at once. With the specialized equipment at Georgia Institute of Technology that analyzed the wafers for adsorbed carbon and sulfur species six compositions were identified to have resistance to carbon and sulfur species. These compositions were deposited on Pall AccuSep® supports by Colorado School of Mines and then tested in simulated synthetic coal gas at the Pall Corporation. Two of the six alloys were chosen for further investigations based on their performance. Alloy reproducibility and long-term testing of PdAuAg and PdZrAu provided insight to the ability to manufacture these compositions for testing. PdAuAg is the most promising alloy found in this work based on the fabrication reproducibility and resistance to carbon and sulfur. Although PdZrAu had great initial resistance to carbon and sulfur species, the alloy composition has a very narrow range that hindered testing reproducibility.

  11. Challenges in the Management of Bleeding Disorders in Nigeria

    African Journals Online (AJOL)

    2018-04-04

    Apr 4, 2018 ... Background: Bleeding disorders (BDs) are characterized by abnormal bleeding for which effective management requires a combination of skill, workforce, diagnostic facilities, and adequate therapeutic options. Objectives: The objectives of this study were to determine the capacity of Nigerian hematologists ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Several small molecule inhibitors have been reported, which not only have high affinity, but also have high specificity to BET BDs. These developments make BET family proteins to be an important therapeutic targets, for major diseases such as cancer, neurological disorders, obesity and inflammation. Here, we review and ...

  13. Polythelia and supernumerary cervical and thoracic vertebrae

    African Journals Online (AJOL)

    2008-10-21

    Oct 21, 2008 ... An 11-year-old boy presented to the Trauma Unit at Red. Cross Hospital after ... Trauma Unit, Department of Paediatric Surgery, Red Cross Children's Hospital and University of Cape Town. S Naidoo, BDS, LDS RCS, ... pass on the genetic information to their offspring, giving rise to either further carriers or ...

  14. Development of the Beidou Ionospheric Observation Network in China for space weather monitoring

    Science.gov (United States)

    Hu, Lianhuan; Yue, Xinan; Ning, Baiqi

    2017-08-01

    The Global Navigation Satellite System (GNSS) beacon has been widely used in ionospheric monitoring. The Chinese Beidou Navigation Satellite System (BDS) started to operate in 2012, with three kinds of constellations: the medium Earth orbit, the inclined geosynchronous satellite orbit, and the geosynchronous Earth orbit. A compact, portable, and low-power GNSS observation instrument which is named BG2 GNSS ionospheric monitor was developed at the Institute of Geology and Geophysics, Chinese Academy of Sciences. It is capable of tracking BDS, Global Positing System, and Global Navigation Satellite System signals with a sampling rate up to 5 Hz. To use the unique BDS GEO signals for ionospheric monitoring, the Beidou Ionospheric Observation Network (BION) utilizing the BG2 GNSS ionospheric monitor was established recently in China with a total of 30 sites. This paper describes the development of the GNSS ionospheric monitor, the construction of the network, data processing, and preliminary scientific research. As demonstrated in the following paper, the BDS GEO total electron content data have shown unique value in some specific ionospheric studies due to the fact that it is not influenced by the mixed effect of spatial and temporal ionospheric variability as observed with other GNSS signals.

  15. Download this PDF file

    African Journals Online (AJOL)

    commendable because this provides crucial information with regard to the planning of relevant surgical services especially when it is universally apparent that most of these neoplasms afflict patients aged below 30 years. M.L. Chindia, BDS, MSc, FFDRCSI, Senior Lecturer, Faculty of Dental. Sciences, University of Nairobi.

  16. The birds of the Republic of Colombia: (Segunda entrega: Accipitridae - Picidae

    Directory of Open Access Journals (Sweden)

    Meyer de Schauensee Rodolphe

    1949-10-01

    Full Text Available Figures given in parentheses are wing measurements from Swann's Monogr. Bds. Prey. Those which do not appear in parentheses are from other published sources, or in most cases they are extreme measurements taken from Colombian specimens by Professor Dugand.

  17. Students' perceived stress and perception of barriers to effective study: impact on academic performance in examinations.

    Science.gov (United States)

    Turner, J; Bartlett, D; Andiappan, M; Cabot, L

    2015-11-13

    To identify students' perceptions of barriers to effective study and the relationship between these and demographic characteristics, levels of perceived stress and examination performance. A questionnaire was distributed to first (BDS1) and final year (BDS5) King's College London dental undergraduates, during Spring 2013. Data were collected on students' social and working environment using a Likert scale from zero to four. Levels of perceived stress and end-of-year examination results were collected. Statistical analyses were undertaken using SPSS® and Stata® software. A response rate of 83.0% (BDS1) and 82.9% (BDS5) was achieved. Social distractions were perceived to hinder study, with median scores of two and three for females and males respectively. The mean perceived stress score differed significantly (p=0.001) between males and females. Difficulties with journey was a significant predictor of perceived stress (p=0.03) as were family responsibilities (p=0.02). Social distractions were significantly related to examination performance (p=0.001). Social distractions were the barrier most highly rated as hindering effective study. Levels of perceived stress were high and were significantly associated with gender, a difficult journey to university and family responsibilities. Social distractions were significantly related to examination performance; students rating social distractions highly, performed less well.

  18. EAMJ March Dental.indd

    African Journals Online (AJOL)

    EAST AFRICAN MEDICAL JOURNAL. March 2009. East African Medical Journal Vol. 85 No. 3 March 2009. DENTAL FLUOROSIS, CARIES EXPERIENCE AND SNACK INTAKE OF 13-15 YEAR OLDS IN KENYA. M. Makhanu, Third year Community Dentistry, BDS Project, Department of Periodontology and Community ...

  19. self-assessed dental health knowledge of nigerian doctors

    African Journals Online (AJOL)

    2013-05-01

    May 1, 2013 ... East African Medical Journal Vol. 90 No. 5 May 2013. SELF-ASSESSED DENTAL HEALTH KNOWLEDGE OF NIGERIAN DOCTORS. S. O. Nwhator, BDS, FMCDS, Senior Consultant Periodontologist, Department of Preventive Dentistry, University of. Abuja Teaching Hospital, Abuja-Nigeria, C. O. Olojede, ...

  20. Observation of Two New Xi(-)(b) Baryon Resonances

    NARCIS (Netherlands)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M. -O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjornstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carson, L.; Akiba, K. Carvalho; Casanova Mohr, R. C. M.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Chen, S.; Cheung, S. -F.; Chiapolini, N.; Chrzaszcz, M.; Vidal, X. Cid; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A. C.; Torres, M. Cruz; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Dean, C. -T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Domenico, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. -M.; Evans, T.; Falabella, A.; Faerber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garcia Pardinas, J.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gastaldi, U.; Gauld, R.; Gavardi, L.; Gazzoni, U.; Geraci, A.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani, S.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Goebel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Gandara, M. Grabalosa; Graciani Diaz, R.; Cardoso, L. A. Granado; Grauges, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griftith, P.; Grillo, L.; Gruenberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; Van Leerdam, J.; Lees, J. -P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Likhomanenko, T.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lowdon, P.; Lucchesi, D.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Benito, C. Mann; Marino, P.; Maerki, R.; Marks, J.; Martellotti, G.; Martinelli, M.; Santos, D. Martinez; Vidal, F. Martinez; Martin Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M. -N.; Moggi, N.; Rodriguez, J. Molina; Monteil, S.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M. J.; Moron, J.; Morris, A. -B.; Mountain, R.; Muheim, F.; Mueller, K.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obratsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Orlandea, M.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Pal, B. K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Altarelli, M. Pepe; Perazzini, S.; Perret, P.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilar, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Navarro, A. Puig; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redi, F.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Perez, P. Rodriguez; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M. -H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepp, I.; Sena, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Sheychenko, V.; Shires, A.; Coutinho, R. Silva; Simi, G.; Sirendi, M.; Skidmore, N.; Skillicorn, I.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Sterpka, F.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; Van Tilburg, J.; Tisserand, V.; Tobin, M.; Todd, J.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Garcia, M. Ubeda; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valenti, G.; Vallier, A.; Gomez, R. Vazquez; Vazquez Regueiro, P.; Vazquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Barbosa, J. V. V. B. Viana; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, C.; de Vries, J. A.; Wraldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Whitehead, M.; Wiedner, D.; Wilkinson, G.; Wilkinson, M.; Williams, M. P.; Williams, M.; Wilschut, H. W.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyae, M.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.

    2015-01-01

    Two structures are observed close to the kinematic threshold in the Xi(0)(b)pi(-) mass spectrum in a sample of proton-proton collision data, corresponding to an integrated luminosity of 3.0 fb(-1), recorded by the LEICb experiment. In the quark model, two baryonic resonances with quark content bds

  1. A Statistical Study of Brown Dwarf Companions from the SDSS-III MARVELS Survey

    Science.gov (United States)

    Grieves, Nolan; Ge, Jian; Thomas, Neil; Ma, Bo; De Lee, Nathan M.; Lee, Brian L.; Fleming, Scott W.; Sithajan, Sirinrat; Varosi, Frank; Liu, Jian; Zhao, Bo; Li, Rui; Agol, Eric; MARVELS Team

    2016-01-01

    We present 23 new Brown Dwarf (BD) candidates from the Multi-object APO Radial-Velocity Exoplanet Large-Area Survey (MARVELS) of the Sloan Digital Sky Survey III (SDSS-III). The BD candidates were selected from the processed MARVELS data using the latest University of Florida 2D pipeline, which shows significant improvement and reduction of systematic errors over the 1D pipeline results included in the SDSS Data Release 12. This sample is the largest BD yield from a single radial velocity survey. Of the 23 candidates, 18 are around main sequence stars and 5 are around giant stars. Given a giant contamination rate of ~24% for the MARVELS survey, we find a BD occurrence rate around main sequence stars of ~0.7%, which agrees with previous studies and confirms the BD desert, while the BD occurrence rate around the MARVELS giant stars is ~0.6%. Preliminary results show that our new candidates around solar type stars support a two population hypothesis, where BDs are divided at a mass of ~42.5 MJup. BDs less massive than 42.5 MJup have eccentricity distributions consistent with planet-planet scattering models, where BDs more massive than 42.5 MJup have both period and eccentricity distributions similar to that of stellar binaries. Special Brown Dwarf systems such as multiple BD systems and highly eccentric BDs will also be presented.

  2. EAMJ Jan. Cancrum 10.indd

    African Journals Online (AJOL)

    2010-01-01

    Jan 1, 2010 ... such as poverty, poor oral hygiene, malnutrition, malaria, preceding viral ... K.J. Koech, BDS, MDS (OMFS), Consultant Oral and Maxillofacial Surgeon, Kenyatta National Hospital, P.O. Box 19552-. 00202, Nairobi, Kenya ... an important pathogenic micro-organism in noma and it is thought to find its way into ...

  3. Current insights into the role of human β-defensins in atopic dermatitis.

    Science.gov (United States)

    Chieosilapatham, P; Ogawa, H; Niyonsaba, F

    2017-11-01

    Anti-microbial peptides or host defence peptides are small molecules that display both anti-microbial activities and complex immunomodulatory functions to protect against various diseases. Among these peptides, the human β-defensins (hBDs) are localized primarily in epithelial surfaces, including those of the skin, where they contribute to protective barriers. In atopic dermatitis skin lesions, altered skin barrier and immune dysregulation are believed to be responsible for reduced hBD synthesis. Impaired hBD expression in the skin is reportedly the leading cause of increased susceptibility to bacterial and viral infection in patients with atopic dermatitis. Although hBDs have considerable beneficial effects as anti-microbial agents and immunomodulators and may ameliorate atopic dermatitis clinically, recent evidence has also suggested the negative effects of hBDs in atopic dermatitis development. In the current review, we provide an overview of the regulation of hBDs and their role in the pathogenesis of atopic dermatitis. The efforts to utilize these molecules in clinical applications are also described. © 2017 British Society for Immunology.

  4. The Effect of a Screenig Instrument on The Prevalence of Dementia ...

    African Journals Online (AJOL)

    Consortium to Establish Registry for Alzheimer's Disease (CERAD), Community Screening Interview for Dementia (CSI-D), Stick Design Test (SDT) and Blessed Dementia Scale (BDS). A standard diagnosis of dementia was made based on fulfilling the diagnostic criteria of dementia in both ICD-10 and DSM- IV.

  5. Bubble detector's evaluation for neutron field measurement in a very known source

    Energy Technology Data Exchange (ETDEWEB)

    Ramalho, Eduardo; Silva, Ademir X. da, E-mail: ademir@nuclear.ufrj.b, E-mail: jdantas@con.ufrj.b [Coordenacao dos Programas de Pos-Graduacao de Engenharia (PEN/COPPE/UFRJ), RJ (Brazil). Programa de Engenharia Nuclear; Reina, Luiz, E-mail: reina@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Facure, Alessandro, E-mail: facure@cnen.gov.b [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    Measurements on neutron fields, mainly for dosimetric purposes, have been a major concern for ionizing radiation workers, because of the radiation protection issues. The present work aims to study the using of bubble detectors in neutron dosimetry and the Bubble Detector Spectrometer (BDS) was chosen for this task. Several experiments were performed in order to obtain spectra from such devices and their respective analysis and then they were compared to those which were obtained by other ways. An Am-Be calibration neutron source from Instituto de Radioprotecao e Dosimetria/Comissao Nacional de Energia Nuclear (IRD/CNEN) was used and its spectrum was compared to the one obtained by BDS. The possibility of the use of such devices as ambient dosimeters was also evaluated. Despite the uncertainties, especially in the lowest energy thresholds, the spectrum from BDS is in good agreement with the known ones and the use of BDS as a dosimeter demands a more detailed study due to some characteristics of the Am-Be source that produce high uncertainties in low energy thresholds. (author)

  6. Search Results | Page 826 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Results 8251 - 8260 of 8491 ... Accumulated environmental, economic, and social damages to date are estimated in the billions of dollars. ... and a comparative analysis of seven case studies that challenge current beliefs about good practice in the provision of business development services (BDS) to small and micro en.

  7. MORPHOMETRIC PARAMETERS OF KENYAN ADULT MANDIBLES

    African Journals Online (AJOL)

    2011-10-10

    Oct 10, 2011 ... L. Chindia, BDS, MSc, FFDRCS, Department of Oral and Maxillofacial Surgery, College of Health Sciences, University of Nairobi, P. O. Box ... the bifurcation of the first molar, 12.36 mm at the bifurcation of the secend molar 8.62 mm at the level of ... The presence of the third molar was taken as an inclusion ...

  8. Sustainability of the Dissemination of an Occupational Sun Protection Program in a Randomized Trial

    Science.gov (United States)

    Buller, David B.; Walkosz, Barbara J.; Andersen, Peter A.; Scott, Michael D.; Dignan, Mark B.; Cutter, Gary R.; Zhang, Xiao; Kane, Ilima L.

    2012-01-01

    Sustainability of an occupational sun safety program, Go Sun Smart (GSS), was explored in a randomized trial, testing dissemination strategies at 68 U.S. and Canadian ski areas in 2004-2007. All ski areas received GSS from the National Ski Areas Association through a Basic Dissemination Strategy (BDS) using conference presentations and free…

  9. 77 FR 18270 - Acceptance Decision for the Unrestricted Use of the Former Michigan Chemical Company-Breckenridge...

    Science.gov (United States)

    2012-03-27

    ..., operated a rare- earth metals processing plant from 1967 through 1970 in St. Louis, Michigan. The plant..., insecticides, animal food supplements, and rare earth oxides. The manufacture of rare-earth oxides at the St... issued a letter to NWI Land Management (NWI), then-owner of the BDS, directing NWI to clean up the site...

  10. Validity and factor structure of the bodybuilding dependence scale.

    Science.gov (United States)

    Smith, D; Hale, B

    2004-04-01

    To investigate the factor structure, validity, and reliability of the bodybuilding dependence scale and to investigate differences in bodybuilding dependence between men and women and competitive and non-competitive bodybuilders. Seventy two male competitive bodybuilders, 63 female competitive bodybuilders, 87 male non-competitive bodybuilders, and 63 non-competitive female bodybuilders completed the bodybuilding dependence scale (BDS), the exercise dependence questionnaire (EDQ), and the muscle dysmorphia inventory (MDI). Confirmatory factor analysis of the BDS supported a three factor model of bodybuilding dependence, consisting of social dependence, training dependence, and mastery dependence (Q = 3.16, CFI = 0.98, SRMR = 0.04). Internal reliability of all three subscales was high (Cronbach's alpha = 0.92, 0.92, and 0.93 respectively). Significant (pbodybuilders scored significantly (pbodybuilders. However, there were no significant sex differences on any of the BDS subscales (p>0.05). The three factor BDS appears to be a reliable and valid measure of bodybuilding dependence. Symptoms of bodybuilding dependence are more prevalent in competitive bodybuilders than non-competitive ones, but there are no significant sex differences in bodybuilding dependence.

  11. Maxillofacial injury: A retrospective analysis of time lapse between ...

    African Journals Online (AJOL)

    2013-11-04

    1,2 BDS, MB BCh, PhD, DSc, FCD. 1 Division of .... where a large force to the body is required (i.e. a serious ... SAJS 141. Table 3. Frequency distribution for the five time groups (days) by study year and for all years combined.

  12. Optimization and validation of high performance liquid ...

    African Journals Online (AJOL)

    Optimization and validation of high performance liquid chromatography-ultra violet method for quantitation of metoprolol in rabbit plasma: application to ... Methods: Mobile phase of methanol and 50 mM ammonium dihydrogen phosphate solution (50:50) at pH 3.05 was used for separation of metoprolol on BDS hypersil ...

  13. Neutron Stars : Magnetism vs Gravity

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Neutron Stars : Magnetism vs Gravity. WHY do neutron stars have such strong magnetic fields? Conservation of magnetic flux of the collapsing stellar core. ∫ B.ds (over surface of the star) = constant; Radius of the star collapses from ~ 5x108 to 1x104 metres; Hence, ...

  14. Australian Disaster Research Directory (Including Some Contributions from New Zealand). Provisional--1983.

    Science.gov (United States)

    1983-06-01

    Adelaide, GPO Box 438, Adelaide, S,:uth Australia 5001 (08) 2285333 Kenneth A Brown BDS, FICD, Senior Lecturer in Forensic Odontology , Department of...which included projects relevant to disaster victim identification, as follows: To develop for Australia internationally compatible odontological methods

  15. Rapid on-site TLC-SERS detection of four antidiabetes drugs used as adulterants in botanical dietary supplements.

    Science.gov (United States)

    Zhu, Qingxia; Cao, Yongbing; Cao, Yingying; Chai, Yifeng; Lu, Feng

    2014-03-01

    A novel facile method has been established for rapid on-site detection of antidiabetes chemicals used to adulterate botanical dietary supplements (BDS) for diabetes. Analytes and components of pharmaceutical matrices were separated by thin-layer chromatography (TLC) then surface-enhanced Raman spectroscopy (SERS) was used for qualitative identification of trace substances on the HPTLC plate. Optimization and standardization of the experimental conditions, for example the method used for preparation of silver colloids, the mobile phase, and the concentration of colloidal silver, resulted in a very robust and highly sensitive method which enabled successful detection when the amount of adulteration was as low as 0.001 % (w/w). The method was also highly selective, enabling successful identification of some chemicals in extremely complex herbal matrices. The established TLC-SERS method was used for analysis of real BDS used to treat diabetes, and the results obtained were verified by liquid chromatography-triple quadrupole mass spectrometry (LC-MS-MS). The study showed that TLC-SERS could be used for effective separation and detection of four chemicals used to adulterate BDS, and would have good prospects for on-site qualitative screening of BDS for adulterants.

  16. Economics | Page 23 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Economics. Économie. Colour. #2C81B5. Building Businesses with Small Producers presents the findings and a comparative analysis of seven case studies that challenge current beliefs about good practice in the provision of business development services (BDS) to small and micro enterprises. The book also highlights ...

  17. Bromodomain and extra-terminal (BET) family proteins: New ...

    Indian Academy of Sciences (India)

    Extensive efforts have been employed by the scientific communities worldwide, to identify and develop potential inhibitors of BET family BDs to regulate protein expression by inhibiting acetylated histone (H3/H4) interactions. Several small molecule inhibitors have been reported, which not only have high affinity, but also ...

  18. The areca nut chewing habit and oral squamous cell carcinoma in ...

    African Journals Online (AJOL)

    catechu. The areca nut-chewing habir involves the. Oral and Dental Research Unit, University ofStellenbosch. C. W. VAN WYK, PH.D., F.D.S. R.e.s., B.CH.D. A. PADAYACHEE, M.CH.D, B.D.S.. Institute for Biostatistics and Centre for Molecular and Cellular. Biology, South African Medical Research Council, Parowvallei,. CP.

  19. Hourly Updated GNSS Orbit and Clock

    Science.gov (United States)

    Song, S.; Xue, J.

    2016-12-01

    With the development of the performance of GNSS, the hourly updated orbit and clock of GNSS are paid much more attention and used by more and more users because of the timeliness and high accuracy. The hourly GNSS orbit and clock are produced routinely in Shanghai Analysis Center(AC) of the International GNSS Monitoring and Assessment Service (iGMAS).In this article, the accuracy of hourly and 6-hourly updated ultra-rapid GPS,GLONASS,GALILEO,BDS orbit and clock (SHU1 and SHU6) are analyzed relative to the final production in detail. The analysis show that, in calculation session, there's no much difference between the mean SHU1 and SHU6 RMS and STD for GNSS orbit and clock. However, for BDS clock in prediction session, the RMS and STD of BDS SHU1 are 2.6ns and 0.5ns respectively, the RMS of BDS SHU6 increase from 2.7ns to 4.5ns from the 1st to the 6th hour prediction session, but there's no much changes of STD. For GPS clock in prediction session, the RMS and STD of GPS SHU1 is quite stable with 0.5ns and 0.2ns.The RMS of GPS SHU6 clock increase from 0.6ns to 1.0ns from the 1st to the 6th hour, but STD is stable at about 0.2ns.For the orbit in calculate session, the RMS of BDS SHU1 is a little less than that of SHU6,the RMS of GPS SHU1 and SHU6 orbit are approximately at the same level. In prediction session, the RMS of IGSO/MEO for BDS SHU1 is relative stable, but the RMS of SHU6 1st-6th hour prediction session increase from about 26.5cm to 32.7cm. The RMS of GPS SHU1 orbit's prediction session is about 3.4cm,but which increase from 3.3cm to 4.3cm for GPS SHU6 1st-6th hour prediction session.The comparison of GLONASS and GALILEO orbit and clock also will be described.The results show that the hourly update is more important for BDS at this stage.Moreover,some problems appearing in satellites and stations can be found earlier by 1 hourly updated frequency.

  20. Intracellular targeting of mercaptoundecahydrododecaborate (BSH) to malignant glioma by transferrin-PEG liposomes for boron neutron capture therapy (BNCT)

    International Nuclear Information System (INIS)

    Doi, Atsushi; Miyatake, Shin-ichi; Iida, Kyouko

    2006-01-01

    Malignant glioma is one of the most difficult tumor to control with usual therapies. In our institute, we select boron neutron capture therapy (BNCT) as an adjuvant radiation therapy after surgical resection. This therapy requires the selective delivery of high concentration of 10 B to malignant tumor tissue. In this study, we focused on a tumor-targeting 10 B delivery system (BDS) for BNCT that uses transferrin-conjugated polyethylene-glycol liposome encapsulating BSH (TF-PEG liposome-BSH) and compared 10 B uptake of the tumor among BSH, PEG liposome-BSH and TF-PEG liposome-BSH. In vitro, we analyzed 10 B concentration of the cultured human U87Δ glioma cells incubated in medium containing 20 μg 10 B/ml derived from each BDS by inductively coupled plasma atomic emission spectrometry (ICP-AES). In vivo, human U87Δ glioma-bearing nude mice were administered with each BDS (35mg 10 B/kg) intravenously. We analyzed 10 B concentration of tumor, normal brain and blood by ICP-AES. The TF-PEG liposome-BSH showed higher absolute concentration more than the other BDS. Moreover, TF-PEG liposome-BSH decreased 10 B concentration in blood and normal tissue while it maintained high 10 B concentration in tumor tissue for a couple of days. This showed the TF-PEG liposome-BSH caused the selective delivery of high concentration of 10 B to malignant tumor tissue. The TF-PEG liposome-BSH is more potent BDS for BNCT to obtain absolute high 10 B concentration and good contrast between tumor and normal tissue than BSH and PEG liposome-BSH. (author)

  1. Production and characterization of a novel yeast extracellular invertase activity towards improved dibenzothiophene biodesulfurization.

    Science.gov (United States)

    Arez, Bruno F; Alves, Luís; Paixão, Susana M

    2014-11-01

    The main goal of this work was the production and characterization of a novel invertase activity from Zygosaccharomyces bailii strain Talf1 for further application to biodesulfurization (BDS) in order to expand the exploitable alternative carbon sources to renewable sucrose-rich feedstock. The maximum invertase activity (163 U ml(-1)) was achieved after 7 days of Z. bailii strain Talf1 cultivation at pH 5.5-6.0, 25 °C, and 150 rpm in Yeast Malt Broth with 25 % Jerusalem artichoke pulp as inducer substrate. The optimum pH and temperature for the crude enzyme activity were 5.5 and 50 °C, respectively, and moreover, high stability was observed at 30 °C for pH 5.5-6.5. The application of Talf1 crude invertase extract (1 %) to a BDS process by Gordonia alkanivorans strain 1B at 30 °C and pH 7.5 was carried out through a simultaneous saccharification and fermentation (SSF) approach in which 10 g l(-1) sucrose and 250 μM dibenzothiophene were used as sole carbon and sulfur sources, respectively. Growth and desulfurization profiles were evaluated and compared with those of BDS without invertase addition. Despite its lower stability at pH 7.5 (loss of activity within 24 h), Talf1 invertase was able to catalyze the full hydrolysis of 10 g l(-1) sucrose in culture medium into invert sugar, contributing to a faster uptake of the monosaccharides by strain 1B during BDS. In SSF approach, the desulfurizing bacterium increased its μmax from 0.035 to 0.070 h(-1) and attained a 2-hydroxybiphenyl productivity of 5.80 μM/h in about 3 days instead of 7 days, corresponding to an improvement of 2.6-fold in relation to the productivity obtained in BDS process without invertase addition.

  2. Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections.

    Science.gov (United States)

    Yanagi, S; Ashitani, J; Imai, K; Kyoraku, Y; Sano, A; Matsumoto, N; Nakazato, M

    2007-01-01

    Human beta-defensins (hBDs) are the most abundant antimicrobial peptides in epithelial cells, and function in the host immune system. Respiratory epithelial cells express hBDs to inhibit bacterial proliferation during respiratory tract infections. The aim of this study was to investigate the release of hBDs into the respiratory tract and their benefit as a host defence system in chronic Pseudomonas aeruginosa infections. The levels of four hBD peptides (hBD-1-hBD-4) were measured in the bronchial epithelial lining fluid (ELF) of nine patients with chronic lower respiratory tract infection caused by P. aeruginosa. Eight patients with idiopathic pulmonary fibrosis and eight volunteers free of pulmonary disease were recruited as controls. ELF was obtained by bronchoscopic microsampling and hBD levels were measured by radioimmunoassays. The antimicrobial effects of hBDs were studied individually and in combination using an in-vitro colony count assay for P. aeruginosa. Concentrations of hBD-1 and hBD-3 tended to be higher in patients with chronic lower respiratory tract infection than in the controls. hBD-2 and hBD-4 were detected in ELF from five and four of nine patients, respectively, but the hBD levels in controls were all below the limits of detection. All patients with infection caused by mucoid P. aeruginosa had detectable hBD-2 and hBD-4 levels in ELF. In-vitro colony count assays showed a potential synergism between hBD-2 and hBD-4 in inhibiting bacterial proliferation. The findings indicate that hBDs, especially hBD-2 and hBD-4, are pathophysiologically important in infections caused by mucoid strains of P. aeruginosa.

  3. Motivations for Botanical Use by Socioeconomically Diverse, Urban Adults: Does Evidence Support Motivation?

    Science.gov (United States)

    Duffy, Grace F; Shupe, Emily Stave; Kuczmarski, Marie Fanelli; Zonderman, Alan B; Evans, Michele K

    2017-10-01

    The study objectives were to characterize botanical dietary supplement (BDS) use and to compare the motivations for botanical supplement (BS) use to the efficacy of the botanical in a socioeconomically and racially diverse urban adult population. Subjects were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, a 20-year prospective health disparities study with African American and white adults from Baltimore, Maryland. All study participants completed two dietary recalls and a dietary supplement (DS) questionnaire in Wave 3 (n = 2140). Diet quality was evaluated by the Healthy Eating Index-2010 and the Mean Adequacy Ratio for 17 micronutrients. A comparison of reported motivations to efficacy reported in the literature of single BS was conducted. Approximately 50% (1062/2140) of participants took DS. Of these, 8% (n = 178) reported taking either BS or BDS. It was found that BDS users had better diet quality than DS users as well as nonusers of DS. The top three motivations for BDS users were to improve overall health, to maintain health, and to supplement the diet. There is limited evidence for the efficacy of most BS. Review of the efficacy of the 15 BS reported by ≥5% of the study population revealed beneficial health roles for only fiber, gingko biloba extract EGb 761, and hawthorn berry. To the authors' knowledge, this study is the first to report a better quality diet with BDS use for a racially diverse urban population. Yet, improvement in diet is needed because overall quality did not achieve current recommendations. To improve overall health, it may be beneficial for this population to focus on dietary modifications to reduce the risks associated with chronic diseases. In general, the reported motivations for BS use were not supported by clinical evidence.

  4. Antibiotic overusage and resistance: A cross-sectional survey among pediatric dentists

    Directory of Open Access Journals (Sweden)

    Sapna Konde

    2016-01-01

    Full Text Available Introduction: Most human orofacial infections originate from odontogenic infections and prescribing antibiotics has become a ubiquitous phenomenon. The World Health Organization (WHO has recognized the inappropriate, indiscriminate, and irrational use of antibiotics leading to antibiotic resistance as a global problem. Objective: The objective of this survey is to compare the antibiotic prescription pattern and the awareness of antibiotic resistance among Bachelor of Dental Surgery (BDS practitioners and pediatric dentists. Materials and methods: A hundred BDS practitioners and 100 pediatric dentists included in the study were given a questionnaire containing both open-ended and closed-ended questions. The questionnaire comprised information pertaining to antibiotic prescription for most common oral conditions, commonly prescribed antibiotics, their dosage, etc. Results: The majority of the practitioners prescribed antibiotics for managing oral diseases. On comparing the prescription patterns between the BDS practitioners and pediatric dentists, there was an overprescription in the BDS group for many conditions, which was statistically significant. Amoxicillin was the most commonly prescribed drug in both the groups. In the presence of an anaerobic infection, the most preferred drug was a combination of amoxicillin and clavulanic acid with metronidazole. With regard to the duration of antibiotic prescription, 74% BDS practitioners prescribed antibiotics as a 3-day course and 60% pediatric dentists resorted to a 5-day course, which was statistically significant. The awareness regarding antibiotic prophylaxis and antibiotic resistance was found to be adequate in both the groups. However, there was a general lack of awareness with regard to the guidelines for antibiotic prescribing in both the groups. Conclusion: Practitioners should prescribe antibiotics in accordance with the guidelines to curb antibiotic resistance, an emerging public health

  5. The Brain of Binge Drinkers at Rest: Alterations in Theta and Beta Oscillations in First-Year College Students with a Binge Drinking Pattern

    Directory of Open Access Journals (Sweden)

    Eduardo López-Caneda

    2017-09-01

    Full Text Available Background: Previous studies have reported anomalous resting brain activity in the electroencephalogram (EEG of alcoholics, often reflected as increased power in the beta and theta frequency bands. The effects of binge drinking, the most common pattern of excessive alcohol consumption during adolescence and youth, on brain activity at rest is still poorly known. In this study, we sought to assess the pattern of resting-state EEG oscillations in college-aged binge drinkers (BDs.Methods: Resting-state brain activity during eyes-open and eyes-closed conditions was recorded from 60 channels in 80 first-year undergraduate students (40 controls and 40 BDs. Cortical sources activity of EEG rhythms was estimated using exact Low-Resolution Electromagnetic Tomography (eLORETA analysis.Results: EEG-source localization analysis revealed that BDs showed, in comparison with controls, significantly higher intracranial current density in the beta frequency band over the right temporal lobe (parahippocampal and fusiform gyri during eyes-open resting state as well as higher intracranial current density in the theta band over the bilateral occipital cortex (cuneus and lingual gyrus during eyes-closed resting condition.Conclusions: These findings are in line with previous results observing increased beta and/or theta power following chronic or heavy alcohol drinking in alcohol-dependent subjects and BDs. Increased tonic beta and theta oscillations are suggestive of an augmented cortical excitability and of potential difficulties in the information processing capacity in young BDs. Furthermore, enhanced EEG power in these frequency bands may respond to a neuromaturational delay as a result of excessive alcohol consumption during this critical brain developmental period.

  6. Inhibition of UV-B induced apoptosis in corneal epithelial cells by potassium channel modulators.

    Science.gov (United States)

    Ubels, John L; Schotanus, Mark P; Bardolph, Susan L; Haarsma, Loren D; Koetje, Leah R; Louters, Julienne R

    2010-02-01

    The goal of this study was to determine whether prevention of K(+) loss can protect human corneal-limbal epithelial (HCLE) cells from UV-B induced apoptosis. Immunostaining for activated caspase-3 of HCLE cells exposed to 150-200 mJ/cm(2) UV-B demonstrated induction of apoptosis 6 h after exposure. The number of apoptotic cells was decreased by incubation in medium with 25 or 100 mM K(+). If this protection is due to a reduction of UV-induced K(+) loss then K(+) channel blockers should also protect HCLE cells from UV-B. Caspase-8 activity induced by exposure to UV-B at 150 mJ/cm(2) was significantly reduced when the cells were incubated in 0.3 microM BDS-I or 0.05-1 mM quinidine. Caspase-3 was also activated by UV-B and a reduction in activity was observed after incubation in 0.1-0.3 microM BDS-I and 0.1-1 mM quinidine. Induction of DNA fragmentation, as measured by the TUNEL assay, was decreased by treatment with 0.3 microM BDS-I and 0.01-0.05 mM quinidine. Patch-clamp recording showed activation of K(+) channels after exposure to UV-B and a decrease in outward K(+) current was observed following application of BDS-I. Quinidine did not block K(+) currents in HCLE cells, suggesting that the protective effect of quinidine occurs by a mechanism other than via K(+) channels. The effect of the K(+) channel blocker BDS-1 on HCLE cells exposed to UV-B confirms that preventing K(+) efflux protects corneal epithelial cells from apoptosis. This suggests the elevated [K(+)] in tears may protect the corneal epithelium from effects of ambient UV-B. Copyright 2009 Elsevier Ltd. All rights reserved.

  7. An orally active Cannabis extract with high content in cannabidiol attenuates chemical induced intestinal inflammation and hypermotility in the mouse

    Directory of Open Access Journals (Sweden)

    Ester Pagano

    2016-10-01

    Full Text Available Anecdotal and scientific evidence suggests that Cannabis use may be beneficial in inflammatory bowel disease (IBD patients. Here, we have investigated the effect of a standardized Cannabis sativa extract with high content of cannabidiol (CBD, here named CBD BDS for CBD botanical drug substance, on mucosal inflammation and hypermotility in mouse models of intestinal inflammation. Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid (DNBS. Motility was evaluated in the experimental model of intestinal hypermotility induced by irritant croton oil. CBD BDS or pure CBD were given - either intraperitoneally or by oral gavage - after the inflammatory insult (curative protocol. The amounts of CBD in the colon, brain and liver after the oral treatments were measured by HPLC coupled to ion trap-time of flight mass spectrometry. CBD BDS, both when given intraperitoneally and by oral gavage, decreased the extent of the damage (as revealed by the decrease in the colon weight/length ratio and myeloperoxidase activity in the DNBS model of colitis. It also reduced intestinal hypermotility (at doses lower than those required to affect transit in healthy mice in the croton oil model of intestinal hypermotility. Under the same experimental conditions, pure CBD did not ameliorate colitis while it normalized croton oil-induced hypermotility when given intraperitoneally (in a dose-related fashion or orally (only at one dose. In conclusion, CBD BDS, given after the inflammatory insult, attenuates injury and motility in intestinal models of inflammation. These findings sustain the rationale of combining CBD with other minor Cannabis constituents and support the clinical development of CBD BDS for IBD treatment.

  8. Inhibition of UV-B Induced Apoptosis in Corneal Epithelial Cells by Potassium Channel Modulators

    Science.gov (United States)

    Ubels, John L.; Schotanus, Mark P.; Bardolph, Susan L.; Haarsma, Loren D.; Koetje, Leah R.; Louters, Julienne R.

    2009-01-01

    The goal of this study was to determine whether prevention of K+ loss can protect human corneal-limbal epithelial (HCLE) cells from UV-B induced apoptosis. Immunostaining for activated caspase-3 of HCLE cells exposed to 150 – 200 mJ/cm2 UV-B demonstrated induction of apoptosis 6 hrs after exposure. The number of apoptotic cells was decreased by incubation in medium with 25 or 100 mM K+. If this protection is due to a reduction of UV induced K+ loss then K+ channel blockers should also protect HCLE cells from UV-B. Caspase-8 activity induced by exposure to UV-B at 150 mJ/cm2 was significantly reduced when the cells were incubated in 0.3 µM BDS-I or 0.05–1 mM quinidine. Caspase-3 was also activated by UV-B and a reduction in activity was observed after incubation in 0.1–0.3 µM BDS-I and 0.1–1mM quinidine. Induction of DNA fragmentation, as measured by the TUNEL assay, was decreased by treatment with 0.3 µM BDS-I and 0.01–0.05 mM quinidine. Patch-clamp recording showed activation of K+ channels after exposure to UV-B and a decrease in outward K+ current was observed following application of BDS-I. Quinidine did not block K+ currents in HCLE cells, suggesting that the protective effect of quinidine occurs by a mechanism other than via K+ channels. The effect of the K+ channel blocker BDS-1 on HCLE cells exposed to UV-B confirms that preventing K+ efflux protects corneal epithelial cells from apoptosis. This suggests the elevated [K+] in tears may protect the corneal epithelium from effects of ambient UV-B. PMID:19874821

  9. PCVs Estimation and their Impacts on Precise Orbit Determination of LEOs

    Science.gov (United States)

    Chunmei, Z.; WANG, X.

    2017-12-01

    In the last decade the precise orbit determination (POD) based on GNSS, such as GPS, has been considered as one of the efficient methods to derive orbits of Low Earth Orbiters (LEOs) that demand accuracy requirements. The Earth gravity field recovery and its related researches require precise dynamic orbits of LEOs. With the improvements of GNSS satellites' orbit and clock accuracy, the algorithm optimization and the refinement of perturbation force models, the antenna phase-center variations (PCVs) of space-borne GNSS receiver have become an increasingly important factor that affects POD accuracy. A series of LEOs such as HY-2, ZY-3 and FY-3 with homebred space-borne GNSS receivers have been launched in the past several years in China. Some of these LEOs load dual-mode GNSS receivers of GPS and BDS signals. The reliable performance of these space-borne receivers has been establishing an important foundation for the future launches of China gravity satellites. Therefore, we first evaluate the data quality of on-board GNSS measurement by examining integrity, multipath error, cycle slip ratio and other quality indices. Then we determine the orbits of several LEOs at different altitudes by the reduced dynamic orbit determination method. The corresponding ionosphere-free carrier phase post-fit residual time series are obtained. And then we establish the PCVs model by the ionosphere-free residual approach and analyze the effects of antenna phase-center variation on orbits. It is shown that orbit accuracy of LEO satellites is greatly improved after in-flight PCV calibration. Finally, focus on the dual-mode receiver of FY-3 satellite we analyze the quality of onboard BDS data and then evaluate the accuracy of the FY-3 orbit determined using only BDS measurement onboard. The accuracy of LEO satellites orbit based on BDS would be well improved with the global completion of BDS by 2020.

  10. Jerusalem artichoke as low-cost fructose-rich feedstock for fossil fuels desulphurization by a fructophilic bacterium.

    Science.gov (United States)

    Silva, T P; Paixão, S M; Roseiro, J C; Alves, L

    2015-03-01

    Through biodesulphurization (BDS) is possible to remove the sulphur present in fossil fuels to carry out the very strict legislation. However, this biological process is limited by the cost of the culture medium, and thus, it is important to explore cheaper alternative carbon sources, such as Jerusalem artichoke (JA). These carbon sources usually contain sulphates which interfere with the BDS process. The goal of this work was to remove the sulphates from Jerusalem artichoke juice (JAJ) through BaCl2 precipitation viewing the optimization of dibenzothiophene (DBT) desulphurization by Gordonia alkanivorans strain 1B. Using a statistical design (Doehlert distribution), the effect of BaCl2 concentration (0.125-0.625%) and pH (5-9) was studied on sulphate concentration in hydrolysed JAJ. A validated surface response derived from data indicated that zero sulphates can be achieved with 0.5-0.55% (w/v) BaCl2 at pH 7; however, parallel BDS assays showed that the highest desulphurization was obtained with the juice treated with 0.5% (w/v) BaCl2 at pH 8.73. Further assays demonstrated that enhanced DBT desulphurization was achieved using hydrolysed JAJ treated in these optimal conditions. A total conversion of 400 μmol l(-1) DBT into 2-hydroxybiphenyl (2-HBP) in <90 h was observed, attaining a 2-HBP maximum production rate of 28.2 μmol l(-1) h(-1) and a specific production rate of 5.06 μmol(-1) g(-1) (DCW) h(-1) . These results highlight the efficacy of the treatment applied to JAJ in making this agromaterial a promising low-cost renewable feedstock for improved BDS by the fructophilic strain 1B. This study is a fundamental step viewing BDS application at the industrial level as it accounts a cost-effective production of the biocatalysts, one of the main drawbacks for BDS scale-up. © 2014 The Society for Applied Microbiology.

  11. Evaluation of atmospheric profiles derived from single- and zero-difference excess phase processing of BeiDou radio occultation data from the FY-3C GNOS mission

    Directory of Open Access Journals (Sweden)

    W. Bai

    2018-02-01

    Full Text Available The Global Navigation Satellite System (GNSS Occultation Sounder (GNOS is one of the new-generation payloads onboard the Chinese FengYun 3 (FY-3 series of operational meteorological satellites for sounding the Earth's neutral atmosphere and ionosphere. The GNOS was designed for acquiring setting and rising radio occultation (RO data by using GNSS signals from both the Chinese BeiDou System (BDS and the US Global Positioning System (GPS. An ultra-stable oscillator with 1 s stability (Allan deviation at the level of 10−12 was installed on the FY-3C GNOS, and thus both zero-difference and single-difference excess phase processing methods should be feasible for FY-3C GNOS observations. In this study we focus on evaluating zero-difference processing of BDS RO data vs. single-difference processing, in order to investigate the zero-difference feasibility for this new instrument, which after its launch in September 2013 started to use BDS signals from five geostationary orbit (GEO satellites, five inclined geosynchronous orbit (IGSO satellites and four medium Earth orbit (MEO satellites. We used a 3-month set of GNOS BDS RO data (October to December 2013 for the evaluation and compared atmospheric bending angle and refractivity profiles, derived from single- and zero-difference excess phase data, against co-located profiles from European Centre for Medium-Range Weather Forecasts (ECMWF analyses. We also compared against co-located refractivity profiles from radiosondes. The statistical evaluation against these reference data shows that the results from single- and zero-difference processing are reasonably consistent in both bias and standard deviation, clearly demonstrating the feasibility of zero differencing for GNOS BDS RO observations. The average bias (and standard deviation of the bending angle and refractivity profiles were found to be about 0.05 to 0.2 % (and 0.7 to 1.6 % over the upper troposphere and lower stratosphere. Zero

  12. Precise orbit determination for quad-constellation satellites at Wuhan University: strategy, result validation, and comparison

    Science.gov (United States)

    Guo, Jing; Xu, Xiaolong; Zhao, Qile; Liu, Jingnan

    2016-02-01

    This contribution summarizes the strategy used by Wuhan University (WHU) to determine precise orbit and clock products for Multi-GNSS Experiment (MGEX) of the International GNSS Service (IGS). In particular, the satellite attitude, phase center corrections, solar radiation pressure model developed and used for BDS satellites are addressed. In addition, this contribution analyzes the orbit and clock quality of the quad-constellation products from MGEX Analysis Centers (ACs) for a common time period of 1 year (2014). With IGS final GPS and GLONASS products as the reference, Multi-GNSS products of WHU (indicated by WUM) show the best agreement among these products from all MGEX ACs in both accuracy and stability. 3D Day Boundary Discontinuities (DBDs) range from 8 to 27 cm for Galileo-IOV satellites among all ACs' products, whereas WUM ones are the largest (about 26.2 cm). Among three types of BDS satellites, MEOs show the smallest DBDs from 10 to 27 cm, whereas the DBDs for all ACs products are at decimeter to meter level for GEOs and one to three decimeter for IGSOs, respectively. As to the satellite laser ranging (SLR) validation for Galileo-IOV satellites, the accuracy evaluated by SLR residuals is at the one decimeter level with the well-known systematic bias of about -5 cm for all ACs. For BDS satellites, the accuracy could reach decimeter level, one decimeter level, and centimeter level for GEOs, IGSOs, and MEOs, respectively. However, there is a noticeable bias in GEO SLR residuals. In addition, systematic errors dependent on orbit angle related to mismodeled solar radiation pressure (SRP) are present for BDS GEOs and IGSOs. The results of Multi-GNSS combined kinematic PPP demonstrate that the best accuracy of position and fastest convergence speed have been achieved using WUM products, particularly in the Up direction. Furthermore, the accuracy of static BDS only PPP degrades when the BDS IGSO and MEO satellites switches to orbit-normal orientation

  13. Evaluation of atmospheric profiles derived from single- and zero-difference excess phase processing of BeiDou radio occultation data from the FY-3C GNOS mission

    Science.gov (United States)

    Bai, Weihua; Liu, Congliang; Meng, Xiangguang; Sun, Yueqiang; Kirchengast, Gottfried; Du, Qifei; Wang, Xianyi; Yang, Guanglin; Liao, Mi; Yang, Zhongdong; Zhao, Danyang; Xia, Junming; Cai, Yuerong; Liu, Lijun; Wang, Dongwei

    2018-02-01

    The Global Navigation Satellite System (GNSS) Occultation Sounder (GNOS) is one of the new-generation payloads onboard the Chinese FengYun 3 (FY-3) series of operational meteorological satellites for sounding the Earth's neutral atmosphere and ionosphere. The GNOS was designed for acquiring setting and rising radio occultation (RO) data by using GNSS signals from both the Chinese BeiDou System (BDS) and the US Global Positioning System (GPS). An ultra-stable oscillator with 1 s stability (Allan deviation) at the level of 10-12 was installed on the FY-3C GNOS, and thus both zero-difference and single-difference excess phase processing methods should be feasible for FY-3C GNOS observations. In this study we focus on evaluating zero-difference processing of BDS RO data vs. single-difference processing, in order to investigate the zero-difference feasibility for this new instrument, which after its launch in September 2013 started to use BDS signals from five geostationary orbit (GEO) satellites, five inclined geosynchronous orbit (IGSO) satellites and four medium Earth orbit (MEO) satellites. We used a 3-month set of GNOS BDS RO data (October to December 2013) for the evaluation and compared atmospheric bending angle and refractivity profiles, derived from single- and zero-difference excess phase data, against co-located profiles from European Centre for Medium-Range Weather Forecasts (ECMWF) analyses. We also compared against co-located refractivity profiles from radiosondes. The statistical evaluation against these reference data shows that the results from single- and zero-difference processing are reasonably consistent in both bias and standard deviation, clearly demonstrating the feasibility of zero differencing for GNOS BDS RO observations. The average bias (and standard deviation) of the bending angle and refractivity profiles were found to be about 0.05 to 0.2 % (and 0.7 to 1.6 %) over the upper troposphere and lower stratosphere. Zero differencing was found

  14. Riiklikud autasud

    Index Scriptorium Estoniae

    2001-01-01

    Vabariigi presidendi Lennart Meri autasud Tallinna Pedagoogikaülikooli õppejõududele: Valgetähe III klass - Heldur Palli (ajaloolane, Demograafia Instituut), Valgetähe IV klass - Mati Heidmets (psühholoogia professor), Valdek Pall (keeleteadlane, emeriitprofessor), Jaan-Mati Punning (geoökoloogia professor), Valgetähe V klass - Toomas Liiv (eesti kirjanduse professor), Viivi Maanso (emakeeleõppejõud), Valgetähe medal - Hergi Karik (keemik, emeriitprofessor), Mare Lott (raamatuteadlane, emeriitprofessor), Evi Rannap (infoteadlane, emeriitprofessor), Eesti Punase Risti IV klass - Taimi Tulva (sotsiaaltöö professor)

  15. Conference on Aerospace Transparent Materials and Enclosures, 18-21 November 1975, Atlanta, Georgia

    Science.gov (United States)

    1976-04-01

    bringing two distinct planes across a void which is not bridged with polymer material. John H. Large, K. B. Armstrong School of Engineering, Development...ALitchfield Park, Arizona -H 195 ABSTRACT EVALUATION OF SCRATCH AND $PALL RESISTANT WINDSHIELDS BY JOHN R. PLUMER U. S. Army Materials and Mechanics...Sternstein arid 1.Ongchin, Polym. Freprints 10, 1117(1969). 365 32. R. N. Haward , B. M. Murphy and E. F. T. White, J. Polym. S’,i. A-2 9 801 (1971). 33. L

  16. Earth observations during Space Shuttle mission STS-28 - 8-13 August 1989

    Science.gov (United States)

    Whitehead, Victor S.; Helfert, M. R.; Lulla, K. P.; Amsbury, D. L.; Runco, S. K.

    1990-01-01

    An overview of the STS-28 earth observation is provided with attention given to meteorology, oceanographic phenomena, and human activity such as urban environments and related land uses. Environmental observations discussed include evidence of a monsoon, vegetation changes such as deforestation, and water pollution and eutrophication of major rivers. Particular attention is paid to atmospheric palls in both the Northern and Southern Hemispheres. Discussion of geological observations focuses on the Mount St. Helens volcano and the little-recognized landform type, the immense illuvial cone. Observation techniques include use of color infrared film and two types of polarization observations.

  17. Reconsidering Figurative, Graphic Art of the 1950s Danish Art Scene

    DEFF Research Database (Denmark)

    Burmeister Kaaring, Liza

    2013-01-01

    The article contributes to a revision of today’s understanding of the 1950s Danish art scene. By presenting three exhibitions and analysing the reception of them, I point out that figurative art enjoyed a much more central role than later accounts have recognised. All three exhibitions were...... entitled Mennesket (Man), and featured figurative, graphic art, concerned with depictions of the human figure and with the post-war psychological condition of the individual human being. Among the artists were Palle Nielsen, Svend Wiig Hansen, Dan Sterup-Hansen and Henry Heerup. The exhibitions took place...

  18. A new species of Astragalus (Fabaceae from west coast of Baikal Lake (Irkutsk Oblast

    Directory of Open Access Journals (Sweden)

    N. V. Stepantsova

    2015-05-01

    Full Text Available A new species, Astragalus rytyensis Stepantsova (Fabaceae, growing on the west coast of the lake Baikal, is described. Morphological differences from related taxa – A. versicolor Pall., A. austrosibiricus Schischk., and A. inopinatus Boriss., are discussed and uncertain position of the new species in the system of the genus is emphasized which is intermediate between subg. Phaca (L. Bunge sect. Hemiphaca Bunge and subg. Cercidothrix Bunge sect. Onobrychium Bunge. Ecological and phonological features of A. rytyensis are reported and chromosome numbers of the new (2n = 6x = 48 and related species are counted.

  19. West Europe Report.

    Science.gov (United States)

    1987-01-12

    Clochemerle [ fictional French town in the Beaujolais area]. However, I only know you through your written or televised statements to the press. I regret... short run Palle Simonsen is Schlüter’s obvious successor. If Schlüter holds out for another 5 or 6 years—and apparently that is what he wants—a...a well-known pro-government satirical weekly. Those who are aware of the situation are uselessly attempting to bring him up-to-date on "PASOK

  20. Hemolytic and toxic properties of Hydra attenuata nematocysts.

    Science.gov (United States)

    Klug, M; Weber, J; Tardent, P

    1989-01-01

    Crude extract prepared from isolated and purified nematocysts (stenoteles, desmonemes, isorhizas) of Hydra attenuata Pall. (Cnidaria, Hydrozoa) contains two main toxic proteins. The first is a hemolysin (100-200,000 mol.wt) which also causes initial spasmodic contractions in larval and adult specimens of Drosophila. Both, hemolytic and neurotoxic activities are inhibited by low concentrations of Triton X-100. The second protein (30-100,000 mol.wt), which is not susceptible to Triton causes long lasting paralysis leading to death of the test animals (LD50 approximately 5 mg crude nematocyst extract per kg). Neither of the toxins is identical with the previously described phospholipase.

  1. Anmeldelser

    Directory of Open Access Journals (Sweden)

    Peter Dragsbo

    2011-12-01

    Full Text Available Anmeldelser af:Birgit Vorre:Boligen i det 20. århundrede. Indretning og brug. Nyt Nordisk Forlag Arnold Busck, 2008, 314 s.Palle Ove Christiansen:Smeden & skaberværket. Tanker om tilværelsen i en vestjysk fabriksby. C.A. Reitzels Forlag, 2008. 167 s.Bent Østergaard:Indvandrerne i Danmarks historie. Kultur- og religionsmøder. Syddansk Universitetsforlag, 2007, 523 s.Christian Tortzen:En sømand han maa lide. Sømændenes Forbund 1897-1997. Bind II. De sidste 50 år. Kampen fortsætter. Pantheon, 2007, 560 s.

  2. A study of the various baffles used in the Marcoule chimneys and the search for a new model (1961)

    International Nuclear Information System (INIS)

    Chassany, J.; Salaun-Penquer, G.

    1961-01-01

    The baffle placed at the top of a chimney determines the shape of the smoke pall for low exit-velocities. The G. 1 type baffle was studied taking into account the characteristics of its collar: totally hollow - partially hollow - solid; on a ribbed chimney or on a plain chimney. The Pu type baffle was also tested. The search for a new type of baffle was limited to variants of the blade - type baffle: - a porous envelope device; - a cone - shaped device and - a deflector of the cupel type. Only the blade-type baffle was rejected, efficient solutions are proposed using the other types or their combinations. (authors) [fr

  3. BFKL Pomeron, Reggeized gluons and Bern-Dixon-Smirnov amplitudes

    CERN Document Server

    Bartels, J; Sabio Vera, Agustin

    2009-01-01

    After a brief review of the BFKL approach to Regge processes in QCD and in supersymmetric (SUSY) gauge theories we propose a strategy for calculating the next-to-next-to-leading order corrections to the BFKL kernel. They can be obtained in terms of various cross-sections for Reggeized gluon interactions. The corresponding amplitudes can be calculated in the framework of the effective action for high energy scattering. In the case of N=4 SUSY it is also possible to use the Bern-Dixon-Smirnov (BDS) ansatz. For this purpose the analytic properties of the BDS amplitudes at high energies are investigated, in order to verify their self-consistency. It is found that, for the number of external particles being larger than five, these amplitudes, beyond one loop, are not in agreement with the BFKL approach which predicts the existence of Regge cuts in some physical channels.

  4. Inhibited-coupling HC-PCF based beam-delivery-system for high power green industrial lasers

    Science.gov (United States)

    Chafer, M.; Gorse, A.; Beaudou, B.; Lekiefs, Q.; Maurel, M.; Debord, B.; Gérôme, F.; Benabid, F.

    2018-02-01

    We report on an ultra-low loss Hollow-Core Photonic Crystal Fiber (HC-PCF) beam delivery system (GLO-GreenBDS) for high power ultra-short pulse lasers operating in the green spectral range (including 515 nm and 532 nm). The GLOBDS- Green combines ease-of-use, high laser-coupling efficiency, robustness and industrial compatible cabling. It comprises a pre-aligned laser-injection head, a sheath-cable protected HC-PCF and a modular fiber-output head. It enables fiber-core gas loading and evacuation in a hermetic fashion. A 5 m long GLO-BDS were demonstrated for a green short pulse laser with a transmission coefficient larger than 80%, and a laser output profile close to single-mode (M2 <1.3).

  5. Incorporation of defects into the central atoms model of a metallic glass

    International Nuclear Information System (INIS)

    Lass, Eric A.; Zhu Aiwu; Shiflet, G.J.; Joseph Poon, S.

    2011-01-01

    The central atoms model (CAM) of a metallic glass is extended to incorporate thermodynamically stable defects, similar to vacancies in a crystalline solid, within the amorphous structure. A bond deficiency (BD), which is the proposed defect present in all metallic glasses, is introduced into the CAM equations. Like vacancies in a crystalline solid, BDs are thermodynamically stable entities because of the increase in entropy associated with their creation, and there is an equilibrium concentration present in the glassy phase. When applied to Cu-Zr and Ni-Zr binary metallic glasses, the concentration of thermally induced BDs surrounding Zr atoms reaches a relatively constant value at the glass transition temperature, regardless of composition within a given glass system. Using this 'critical' defect concentration, the predicted temperatures at which the glass transition is expected to occur are in good agreement with the experimentally determined glass transition temperatures for both alloy systems.

  6. Quadrupole-free detector optics design for the Compact Linear Collider final focus system at 3 TeV

    Directory of Open Access Journals (Sweden)

    Fabien Plassard

    2018-01-01

    Full Text Available Aiming to simplify the machine detector interface of the Compact Linear Collider (CLIC, a new detector model has been designed allowing the last quadrupole QD0 of the final focus system (FFS to be located outside of the experiment with a distance L^{*} from the interaction point of 6 m. In this paper, the beam delivery system (BDS has been reoptimized, offering a luminosity performance that exceeds the design requirements by 11% for the total luminosity and by 7% in the energy peak. A simulation campaign has been carried out and has proved the feasibility of recovering the luminosity under realistic transverse misalignments of the FFS optics, by means of different orbit and aberration correction techniques, making this long L^{*} design a realistic candidate for the future CLIC BDS.

  7. Adaptive differential correspondence imaging based on sorting technique

    Directory of Open Access Journals (Sweden)

    Heng Wu

    2017-04-01

    Full Text Available We develop an adaptive differential correspondence imaging (CI method using a sorting technique. Different from the conventional CI schemes, the bucket detector signals (BDS are first processed by a differential technique, and then sorted in a descending (or ascending order. Subsequently, according to the front and last several frames of the sorted BDS, the positive and negative subsets (PNS are created by selecting the relative frames from the reference detector signals. Finally, the object image is recovered from the PNS. Besides, an adaptive method based on two-step iteration is designed to select the optimum number of frames. To verify the proposed method, a single-detector computational ghost imaging (GI setup is constructed. We experimentally and numerically compare the performance of the proposed method with different GI algorithms. The results show that our method can improve the reconstruction quality and reduce the computation cost by using fewer measurement data.

  8. Quadrupole-free detector optics design for the Compact Linear Collider final focus system at 3 TeV

    Science.gov (United States)

    Plassard, Fabien; Latina, Andrea; Marin, Eduardo; Tomás, Rogelio; Bambade, Philip

    2018-01-01

    Aiming to simplify the machine detector interface of the Compact Linear Collider (CLIC), a new detector model has been designed allowing the last quadrupole QD0 of the final focus system (FFS) to be located outside of the experiment with a distance L* from the interaction point of 6 m. In this paper, the beam delivery system (BDS) has been reoptimized, offering a luminosity performance that exceeds the design requirements by 11% for the total luminosity and by 7% in the energy peak. A simulation campaign has been carried out and has proved the feasibility of recovering the luminosity under realistic transverse misalignments of the FFS optics, by means of different orbit and aberration correction techniques, making this long L* design a realistic candidate for the future CLIC BDS.

  9. [Therapeutic effects of scalp-acupuncture in patients with vascular dementia induced by cerebral infarction: a randomized controlled trial].

    Science.gov (United States)

    Liu, Yi-cheng; Zhang, Hong-xing; Chen, Guo-hua; Wu, Wen-li; Hu, Jing-jing; Wan, Wen-jun; Ma, Chao-yang

    2008-08-01

    To investigate the effects of scalp-acupuncture on intelligence in patients with vascular dementia (VaD). A total of 108 VaD patients were randomly divided into two groups: scalp-acupuncture group and Western medicine group. The scores of Mini-Mental State Examination (MMSE), Blesse Dementia Scale (BDS), Hasegawa Dementia Scale (HDS), Abilities of Daily Life (ADL) before and after treatment in the two groups were detected. A total of 92 patients completed the treatment. The scores of MMSE, BDS and HDS in the two groups were significantly increased, and the ADL scores significantly declined (P0.05). Scalp-acupuncture therapy could improve the clinical intelligence level of VaD patients.

  10. Barium titanate nanocomposite capacitor FY09 year end report.

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, Tyler E.; DiAntonio, Christopher Brian; Yang, Pin; Chavez, Tom P.; Winter, Michael R.; Monson, Todd C.; Roesler, Alexander William; Fellows, Benjamin D.

    2009-11-01

    This late start RTBF project started the development of barium titanate (BTO)/glass nanocomposite capacitors for future and emerging energy storage applications. The long term goal of this work is to decrease the size, weight, and cost of ceramic capacitors while increasing their reliability. Ceramic-based nanocomposites have the potential to yield materials with enhanced permittivity, breakdown strength (BDS), and reduced strain, which can increase the energy density of capacitors and increase their shot life. Composites of BTO in glass will limit grain growth during device fabrication (preserving nanoparticle grain size and enhanced properties), resulting in devices with improved density, permittivity, BDS, and shot life. BTO will eliminate the issues associated with Pb toxicity and volatility as well as the variation in energy storage vs. temperature of PZT based devices. During the last six months of FY09 this work focused on developing syntheses for BTO nanoparticles and firing profiles for sintering BTO/glass composite capacitors.

  11. A step towards a new delimitation of functional somatic syndromes

    DEFF Research Database (Denmark)

    Eliasen, Marie; Schröder, Andreas; Fink, Per

    2018-01-01

    OBJECTIVES: The current delimitation of functional somatic syndromes (FSS) is inconsistent. We aimed to investigate somatic symptom profiles in the general adult population to contribute to a new, data-driven delimitation of FSS. METHODS: Information on 31 self-reported somatic symptoms used...... with sex, age, chronic disease, self-perceived health, symptom impact, self-reported FSS, and BDS case-status. RESULTS: Eight symptom profiles were identified. The largest profile had no symptoms (49% of the population). Three profiles were characterized by a few, specific symptoms: muscle and joint pain...... identified eight symptom profiles characterized by specific combinations of symptoms. Four of these had multiple symptoms from several bodily systems showing large overlap with BDS, possibly indicating subtypes of FSS. The profiles contribute to a new delimitation of FSS by illustrating the importance...

  12. Baseline Caries Risk Assessment Using CAMBRA May Predict Caries Only in High and Extreme Caries Risk Groups.

    Science.gov (United States)

    Tellez, Marisol; Bhoopathi, Vinodh; Lim, Sungwoo

    2015-12-01

    Baseline caries risk assessment as a predictor of caries incidence. Chaffee BW, Cheng J, Featherstone JD.J Dent 2015;43(5):518-24. Marisol Tellez, BDS, MPH, PhD, Vinodh Bhoopathi, BDS, MPH, DScD, Sungwoo Lim, MS, DrPH PURPOSE/QUESTION: To determine, with each increasing category of baseline caries risk as assessed by Caries Management by Risk Assessment (CAMBRA) in a patient, whether a greater or higher number of new decay/restored teeth can be predicted at a subsequent 6-month periodic oral evaluation. National Center for Advancing Translational Sciences, National Institutes of Health (KL2TR000143) TYPE OF STUDY/DESIGN: Retrospective cohort study Level 2: Limited-quality, patientoriented evidence Not applicable. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Dinámica no lineal estocástica del mercado cambiario mexicano

    Directory of Open Access Journals (Sweden)

    Klender Aimer Cortez Alejandro

    2011-07-01

    Full Text Available This paper presents an analysis of the exchange rate volatility in the Mexican market during the flotation regime adopted since December 1994. The time series under study are the bid and ask interbank daily exchange rates from 1995 to 2010. As a starting point we begin analyzing the temporary structure of the variance, and later we look for a time serie model that best fits the data. In order to detect the non-linear dynamic of the time series, we use the BDS test. The results show evidence in favor of the caractertización of the exchange change pesos/dollar fluctuations with non-linear stochastic models, particularly the GARCH model. In order to validate the model we propose to use the bootstrapping technique together with the BDS test.

  14. 1,25-Dihydroxyvitamin-D3 Induces Avian β-Defensin Gene Expression in Chickens.

    Directory of Open Access Journals (Sweden)

    Long Zhang

    Full Text Available Host defense peptides (HDPs play a critical role in innate immunity. Specific modulation of endogenous HDP synthesis by dietary compounds has been regarded as a novel approach to boost immunity and disease resistance in animal production. 1,25-dihydroxy vitamin D3 (1,25D3 is well known as a powerful HDP inducer in humans, but limited information about the effect of 1,25D3 on HDPs in poultry is available. Here, we sought to examine whether 1,25D3 could stimulate avian β-defensin (AvBD expression in chickens. We used chicken embryo intestinal epithelial cells (CEIEPCs and peripheral blood mononuclear cells (PBMCs to study the effect of 1,25D3 on the expression of AvBDs. We observed that 1,25D3 is able to up-regulate the expression of several AvBDs in CEIEPCs and PBMCs, whereas it increased the amounts of AvBD4 mRNA in CEIEPCs only in the presence of lipopolysaccharide (LPS. On the other hand, LPS treatment not only inhibited the expression of CYP24A1 but also altered the expression pattern of VDR in CEIEPCs. Furthermore, AvBDs were not directly regulated by 1,25D3, as cycloheximide completely blocked 1,25D3-induced expression of AvBDs. Our observations suggest that 1,25D3 is capable of inducing AvBD gene expression and is a potential antibiotic alternative through augmentation of host innate immunity as well as disease control in chickens.

  15. Overcoming the Challenges of BeiDou Receiver Implementation

    Directory of Open Access Journals (Sweden)

    Mohammad Zahidul H. Bhuiyan

    2014-11-01

    Full Text Available Global Navigation Satellite System (GNSS-based positioning is experiencing rapid changes. The existing GPS and the GLONASS systems are being modernized to better serve the current challenging applications under harsh signal conditions. These modernizations include increasing the number of transmission frequencies and changes to the signal components. In addition, the Chinese BeiDou Navigation Satellite system (BDS and the European Galileo are currently under development for global operation. Therefore, in view of these new upcoming systems the research and development of GNSS receivers has been experiencing a new upsurge. In this article, the authors discuss the main functionalities of a GNSS receiver in view of BDS. While describing the main functionalities of a software-defined BeiDou receiver, the authors also highlight the similarities and differences between the signal characteristics of the BeiDou B1 open service signal and the legacy GPS L1 C/A signal, as in general they both exhibit similar characteristics. In addition, the authors implement a novel acquisition technique for long coherent integration in the presence of NH code modulation in BeiDou D1 signal. Furthermore, a simple phase-preserved coherent integration based acquisition scheme is implemented for BeiDou GEO satellite acquisition. Apart from the above BeiDou-specific implementations, a novel Carrier-to-Noise-density ratio estimation technique is also implemented in the software receiver, which does not necessarily require bit synchronization prior to estimation. Finally, the authors present a BeiDou-only position fix with the implemented software-defined BeiDou receiver considering all three satellite constellations from BDS. In addition, a true multi-GNSS position fix with GPS and BDS systems is also presented while comparing their performances for a static stand-alone code phase-based positioning.

  16. Characteristics of BeiDou Navigation Satellite System Multipath and Its Mitigation Method Based on Kalman Filter and Rauch-Tung-Striebel Smoother.

    Science.gov (United States)

    Zhang, Qiuzhao; Yang, Wei; Zhang, Shubi; Liu, Xin

    2018-01-12

    Global Navigation Satellite System (GNSS) carrier phase measurement for short baseline meets the requirements of deformation monitoring of large structures. However, the carrier phase multipath effect is the main error source with double difference (DD) processing. There are lots of methods to deal with the multipath errors of Global Position System (GPS) carrier phase data. The BeiDou navigation satellite System (BDS) multipath mitigation is still a research hotspot because the unique constellation design of BDS makes it different to mitigate multipath effects compared to GPS. Multipath error periodically repeats for its strong correlation to geometry of satellites, reflective surface and antenna which is also repetitive. We analyzed the characteristics of orbital periods of BDS satellites which are consistent with multipath repeat periods of corresponding satellites. The results show that the orbital periods and multipath periods for BDS geostationary earth orbit (GEO) and inclined geosynchronous orbit (IGSO) satellites are about one day but the periods of MEO satellites are about seven days. The Kalman filter (KF) and Rauch-Tung-Striebel Smoother (RTSS) was introduced to extract the multipath models from single difference (SD) residuals with traditional sidereal filter (SF). Wavelet filter and Empirical mode decomposition (EMD) were also used to mitigate multipath effects. The experimental results show that the three filters methods all have obvious effect on improvement of baseline accuracy and the performance of KT-RTSS method is slightly better than that of wavelet filter and EMD filter. The baseline vector accuracy on east, north and up (E, N, U) components with KF-RTSS method were improved by 62.8%, 63.6%, 62.5% on day of year 280 and 57.3%, 53.4%, 55.9% on day of year 281, respectively.

  17. Characteristics of BeiDou Navigation Satellite System Multipath and Its Mitigation Method Based on Kalman Filter and Rauch-Tung-Striebel Smoother

    Directory of Open Access Journals (Sweden)

    Qiuzhao Zhang

    2018-01-01

    Full Text Available Global Navigation Satellite System (GNSS carrier phase measurement for short baseline meets the requirements of deformation monitoring of large structures. However, the carrier phase multipath effect is the main error source with double difference (DD processing. There are lots of methods to deal with the multipath errors of Global Position System (GPS carrier phase data. The BeiDou navigation satellite System (BDS multipath mitigation is still a research hotspot because the unique constellation design of BDS makes it different to mitigate multipath effects compared to GPS. Multipath error periodically repeats for its strong correlation to geometry of satellites, reflective surface and antenna which is also repetitive. We analyzed the characteristics of orbital periods of BDS satellites which are consistent with multipath repeat periods of corresponding satellites. The results show that the orbital periods and multipath periods for BDS geostationary earth orbit (GEO and inclined geosynchronous orbit (IGSO satellites are about one day but the periods of MEO satellites are about seven days. The Kalman filter (KF and Rauch-Tung-Striebel Smoother (RTSS was introduced to extract the multipath models from single difference (SD residuals with traditional sidereal filter (SF. Wavelet filter and Empirical mode decomposition (EMD were also used to mitigate multipath effects. The experimental results show that the three filters methods all have obvious effect on improvement of baseline accuracy and the performance of KT-RTSS method is slightly better than that of wavelet filter and EMD filter. The baseline vector accuracy on east, north and up (E, N, U components with KF-RTSS method were improved by 62.8%, 63.6%, 62.5% on day of year 280 and 57.3%, 53.4%, 55.9% on day of year 281, respectively.

  18. The Flipped Classroom for pre-clinical dental skills teaching - a reflective commentary.

    Science.gov (United States)

    Crothers, A J; Bagg, J; McKerlie, R

    2017-05-12

    A Flipped Classroom method for teaching of adult practical pre-clinical dental skills was introduced to the BDS curriculum in Glasgow during the 2015/2016 academic session. This report provides a commentary of the first year of employing this method - from the identification of the need to optimise teaching resources, through the planning, implementation and development of the method, with an early indication of performance.

  19. Sexual Dysfunction and Incidence of Depression in Multiple Sclerosis Patients

    Science.gov (United States)

    Zavoreo, Iris; Gržinčić, Tihana; Preksavec, Marina; Madžar, Tomislav; Bašić Kes, Vanja

    2016-09-01

    Multiple sclerosis (MS) is one of the most common diseases of the central nervous system and usually occurs at the age when people would be expected to be in the prime of their sexual lives. In everyday practice, sexual dysfunction is underestimated because clinicians mostly concentrate on the classic neurologic deficits and often overlook symptoms that can seriously affect the quality of life. Our study included 98 patients (42 men and 56 women, mean age 35±12 years) with relapse from our MS register, with established diagnosis of relapsing remitting multiple sclerosis according to McDonald criteria. Patients completed the questionnaires (Sexual Satisfaction Scale, SSS and Beck Depression Scale BDS), and underwent neurological assessment (Expanded Disability Status Scale, EDSS). All patients were in the group with EDSS 2 to 4 points (mobile patients). There was no statistically significant difference in BDS and SSS values according to EDSS score. Correlation coefficients were calculated (BDS and SSS) for men (p=0.42) and women (p=0.44), yielding positive correlation. There was no statistically significant difference in BDS and SSS values according to gender, disease duration or immunomodulatory therapy. In our group of patients, despite low EDSS score (fully ambulatory without aid, self sufficient patients) we found positive correlation between sexual dysfunction and depression, showing that even in such patients the quality of life can be decreased. In conclusion, sexual dysfunction and depression are mostly under-recognized by neurologists because they are not part of routine testing; therefore, some additional questionnaires should be used in the evaluation in MS patients, even those with low EDSS score, in order to improve their quality of life.

  20. Improvement of orbit determination accuracy for Beidou Navigation Satellite System with Two-way Satellite Time Frequency Transfer

    Science.gov (United States)

    Tang, Chengpan; Hu, Xiaogong; Zhou, Shanshi; Guo, Rui; He, Feng; Liu, Li; Zhu, Lingfeng; Li, Xiaojie; Wu, Shan; Zhao, Gang; Yu, Yang; Cao, Yueling

    2016-10-01

    The Beidou Navigation Satellite System (BDS) manages to estimate simultaneously the orbits and clock offsets of navigation satellites, using code and carrier phase measurements of a regional network within China. The satellite clock offsets are also directly measured with Two-way Satellite Time Frequency Transfer (TWSTFT). Satellite laser ranging (SLR) residuals and comparisons with the precise ephemeris indicate that the radial error of GEO satellites is much larger than that of IGSO and MEO satellites and that the BDS orbit accuracy is worse than GPS. In order to improve the orbit determination accuracy for BDS, a new orbit determination strategy is proposed, in which the satellite clock measurements from TWSTFT are fixed as known values, and only the orbits of the satellites are solved. However, a constant systematic error at the nanosecond level can be found in the clock measurements, which is obtained and then corrected by differencing the clock measurements and the clock estimates from orbit determination. The effectiveness of the new strategy is verified by a GPS regional network orbit determination experiment. With the IGS final clock products fixed, the orbit determination and prediction accuracy for GPS satellites improve by more than 50% and the 12-h prediction User Range Error (URE) is better than 0.12 m. By processing a 25-day of measurement from the BDS regional network, an optimal strategy for the satellite-clock-fixed orbit determination is identified. User Equivalent Ranging Error is reduced by 27.6% for GEO satellites, but no apparent reduction is found for IGSO/MEO satellites. The SLR residuals exhibit reductions by 59% and 32% for IGSO satellites but no reductions for GEO and MEO satellites.

  1. Simultaneous HPLC quantitative analysis of mangostin derivatives in Tetragonula pagdeni propolis extracts

    OpenAIRE

    Kongkiatpaiboon, Sumet; Vongsak, Boonyadist; Machana, Sasipawan; Weerakul, Thorsang; Pattarapanich, Chamnan

    2016-01-01

    Propolis has been used as indigenous medicine for curing numerous maladies. The one that is of ethnopharmacological use is stingless bee propolis from Tetragonula pagdeni. A simultaneous high-performance liquid chromatography (HPLC) investigation was developed and validated to determine the contents of bioactive compounds: 3-isomangostin, gamma-mangostin, beta-mangostin, and alpha-mangostin. HPLC analysis was effectively performed using a Hypersil BDS C18 column, with the gradient elution of ...

  2. A crucial role of paralogous β-defensin genes in the Chinese alligator innate immune system revealed by the first determination of a Crocodilia defensin cluster.

    Science.gov (United States)

    Tang, Ke-Yi; Wang, Xin; Wan, Qiu-Hong; Fang, Sheng-Guo

    2018-04-01

    The β-defensin, one of the antimicrobial peptides (AMPs), is a significant component of the innate immune with a broad range of antimicrobial activities. Differing from the widely-studied mammals and birds, limited information about β-defensins has been reported in reptiles, especially in crocodilians. As a same ancient species as dinosaurs and the most endangered species of 23 crocodilians, the survival of Chinese alligator (Alligator sinensis) means a powerful immune system and possible involvement of AMPs in its immune resistance. In this study, we identified 20 novel Alligator sinensisβ-defensin genes (AsBDs) from a 390 kb region using bioinformatic and experimental approaches, and successfully distinguished six orthologous AsBDs to birds and nine paralogous AsBDs undergoing gene duplication events. The amino acid alignment shows that the AsBD paralogs, like α-defensins, encode a significantly longer pro-piece comparing with the orthologs. The calculation of non-synonymous (d N ) and synonymous (d S ) substitutions in the mature peptide reveals that the AsBD paralogs experience a significantly higher selective pressure (d N /d S ) than the orthologs, but a similar evolutionary force to α-defensins. The gene expression result indicates that the AsBD paralogs have a significantly higher expression level than the orthologos in gastrointestinal tract where the host is vulnerable to enteric pathogenic bacteria, as observed in α-defensins. These three pieces of evidence demonstrate that the AsBD paralogs do play an important role in maintaining long-term survival of this endangered reptile. Thus, this survey of AsBDs on the genomic structure, evolutionary characteristics, and expression pattern provides a genetic and immunological foundation for further investigating their antimicrobial function and alternative antibiotics potentiality. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  3. The Impact of Estimating High-Resolution Tropospheric Gradients on Multi-GNSS Precise Positioning.

    Science.gov (United States)

    Zhou, Feng; Li, Xingxing; Li, Weiwei; Chen, Wen; Dong, Danan; Wickert, Jens; Schuh, Harald

    2017-04-03

    Benefits from the modernized US Global Positioning System (GPS), the revitalized Russian GLObal NAvigation Satellite System (GLONASS), and the newly-developed Chinese BeiDou Navigation Satellite System (BDS) and European Galileo, multi-constellation Global Navigation Satellite System (GNSS) has emerged as a powerful tool not only in positioning, navigation, and timing (PNT), but also in remote sensing of the atmosphere and ionosphere. Both precise positioning and the derivation of atmospheric parameters can benefit from multi-GNSS observations. In this contribution, extensive evaluations are conducted with multi-GNSS datasets collected from 134 globally-distributed ground stations of the International GNSS Service (IGS) Multi-GNSS Experiment (MGEX) network in July 2016. The datasets are processed in six different constellation combinations, i.e., GPS-, GLONASS-, BDS-only, GPS + GLONASS, GPS + BDS, and GPS + GLONASS + BDS + Galileo precise point positioning (PPP). Tropospheric gradients are estimated with eight different temporal resolutions, from 1 h to 24 h, to investigate the impact of estimating high-resolution gradients on position estimates. The standard deviation (STD) is used as an indicator of positioning repeatability. The results show that estimating tropospheric gradients with high temporal resolution can achieve better positioning performance than the traditional strategy in which tropospheric gradients are estimated on a daily basis. Moreover, the impact of estimating tropospheric gradients with different temporal resolutions at various elevation cutoff angles (from 3° to 20°) is investigated. It can be observed that with increasing elevation cutoff angles, the improvement in positioning repeatability is decreased.

  4. Donor Hemovigilance with Blood Donation

    Science.gov (United States)

    Diekamp, Ulrich; Gneißl, Johannes; Rabe, Angela; Kießig, Stephan T.

    2015-01-01

    Background Reports on unexpected events (UEs) during blood donation (BD) inadequately consider the role of technical UEs. Methods Defined local and systemic UEs were graded by severity; technical UEs were not graded. On January 1, 2008, E.B.P.S.-Logistics (EBPS) installed the UE module for plasma management software (PMS). Donor room physicians entered UEs daily into PMS. Medical directors reviewed entries quarterly. EBPS compiled data on donors, donations, and UEs from January 1, 2008 to June 30, 2011. Results 6,605 UEs were observed during 166,650 BDs from 57,622 donors for a corrected incidence of 4.30% (0.66% local, 1.59% systemic, 2.04% technical UEs). 2.96% of BDs were accompanied by one UE and 0.45% by >1 UE (2-4). 6.3% of donors donating blood for their first time, 3.5% of those giving blood for their second time, and 1.9% of donors giving their third or more BD experienced UEs. Most common UEs were: discontinued collections due to venous access problems, repeated venipuncture, and small hematomas. Severe circulatory UEs occurred at a rate of 16 per 100,000 BDs. Conclusions Technical UEs were common during BD. UEs accompanied first and second donations significantly more often than subsequent donations. PMID:26195932

  5. Novel Budesonide Particles for Dry Powder Inhalation Prepared Using a Microfluidic Reactor Coupled With Ultrasonic Spray Freeze Drying.

    Science.gov (United States)

    Saboti, Denis; Maver, Uroš; Chan, Hak-Kim; Planinšek, Odon

    2017-07-01

    Budesonide (BDS) is a potent active pharmaceutical ingredient, often administered using respiratory devices such as metered dose inhalers, nebulizers, and dry powder inhalers. Inhalable drug particles are conventionally produced by crystallization followed by milling. This approach tends to generate partially amorphous materials that require post-processing to improve the formulations' stability. Other methods involve homogenization or precipitation and often require the use of stabilizers, mostly surfactants. The purpose of this study was therefore to develop a novel method for preparation of fine BDS particles using a microfluidic reactor coupled with ultrasonic spray freeze drying, and hence avoiding the need of additional homogenization or stabilizer use. A T-junction microfluidic reactor was employed to produce particle suspension (using an ethanol-water, methanol-water, and an acetone-water system), which was directly fed into an ultrasonic atomization probe, followed by direct feeding to liquid nitrogen. Freeze drying was the final preparation step. The result was fine crystalline BDS powders which, when blended with lactose and dispersed in an Aerolizer at 100 L/min, generated fine particle fraction in the range 47.6% ± 2.8% to 54.9% ± 1.8%, thus exhibiting a good aerosol performance. Subsequent sample analysis confirmed the suitability of the developed method to produce inhalable drug particles without additional homogenization or stabilizers. The developed method provides a viable solution for particle isolation in microfluidics in general. Copyright © 2017 American Pharmacists Association®. All rights reserved.

  6. The NOTOM hypothesis for idiopathic scoliosis: is it nullified by the delayed puberty of female rhythmic gymnasts and ballet dancers with scoliosis?

    Science.gov (United States)

    Burwell, R G; Dangerfield, P H

    2002-01-01

    Nachemson suggested that there are more girls than boys with progressive adolescent idiopathic because of a different timing between skeletal maturation and postural maturation in the sexes during adolescence. We termed Nachemson's concept the neuro-osseous timing of maturation (NOTOM) hypothesis and used it to propose a possible medical treatment for idiopathic scoliosis by delaying puberty through the pituitary using gonadorelin analogues as in idiopathic precocious puberty. The prevalence of scoliosis is reported to be increased in rhythmic gymnasts (RGs) in Bulgaria and in ballet dancers (BDs) in the USA. Both groups exhibit delayed puberty, which, at first sight, nullifies the NOTOM hypothesis for idiopathic scoliosis. While constitutional and environmental factors may determine these scolioses, the different curve types in RGs and BDs suggest that the exercise pattern over many years determines which type of scoliosis develops, although not the curve severity. We support the view that scoliotic RGs should be included in a group of sports-associated scoliosis separate from idiopathic scoliosis. Hence the delayed puberty of RGs and BDs with scoliosis does not nullify the NOTOM hypothesis as their scolioses are not idiopathic. There is a need to focus research on such subjects who have defined constitutional and environmental factors related to their scolioses.

  7. Conceptual Perspectives: Bacterial Antimicrobial Peptide Induction as a Novel Strategy for Symbiosis with the Human Host

    Directory of Open Access Journals (Sweden)

    Santosh K. Ghosh

    2018-02-01

    Full Text Available Human beta defensins (hBDs are small cationic peptides, expressed in mucosal epithelia and important agents of innate immunity, act as antimicrobial and chemotactic agents at mucosal barriers. In this perspective, we present evidence supporting a novel strategy by which the oral bacterium Fusobacterium nucleatum induces hBDs and other antimicrobial peptides (AMPs in normal human oral epithelial cells (HOECs and thereby protects them from other microbial pathogens. The findings stress (1 the physiological importance of hBDs, (2 that this strategy may be a mechanism that contributes to homeostasis and health in body sites constantly challenged with bacteria and (3 that novel properties identified in commensal bacteria could, one day, be harnessed as new probiotic strategies to combat colonization of opportunistic pathogens. With that in mind, we highlight and review the discovery and characterization of a novel lipo-protein, FAD-I (FusobacteriumAssociated Defensin Inducer associated with the outer membrane of F. nucleatum that may act as a homeostatic agent by activating endogenous AMPs to re-equilibrate a dysregulated microenvironment. FAD-I has the potential to reduce dysbiosis-driven diseases at a time when resistance to antibiotics is increasing. We therefore postulate that FAD-I may offer a new paradigm in immunoregulatory therapeutics to bolster host innate defense of vulnerable mucosae, while maintaining physiologically responsive states of inflammation.

  8. Nonthyroidal illness syndrome in patients with subarachnoid hemorrhage due to intracranial aneurysm Sindrome da doença não tiroideana em pacientes com hemorragia subaracnoidea devida a aneurisma cerebral

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Casulari

    2004-03-01

    Full Text Available We have previously reported that subarachnoid hemorrhage due to ruptured intracranial aneurysm (SH is associated with changes in the hormonal profile in the first 24 hours after the event. We proposed that the hormonal changes observed are due to the intense stress to which the patients are exposed. However, the thyroidal hormonal profile is indicative of the presence of a nonthyroidal illness syndrome (NTIS. In this paper, we examined whether the change in the thyroid hormone profile is compatible with a NTIS. Two groups of patients were included in the study: A 30 patients with SH (21 females and 9 males; 41.7±11.4 years and B a control group including 25 patients with benign diseases of the spine (BDS (lumbar disc hernia or stable spinal trauma (8 females and 17 males; 41.3±14.2 years. In a subgroup of eight patients of each group serum triiodothyronine (T3 and reverse T3 levels were measured. The blood samples were obtained between 8:00 and 9:00 AM. The following results were obtained: The SH group had smaller serum T3 and free T4 levels than the BDS group (pNós apresentamos previamente que a hemorragia subaracnoidea devido à ruptura de aneurisma intracraniano (SH está associada com alterações no perfil hormonal nas primeiras 24 horas após o evento. Nós propusemos que as alterações hormonais observadas são devidas ao intenso estresse ao qual os pacientes estão expostos. Contudo, o perfil hormonal tireoidiano é indicativo da presença da síndrome da doença não tireoidiana (NTIS. Neste trabalho, examinamos se as alterações no perfil dos hormônios tireoidianos são compatíveis com a NTIS. Dois grupos de pacientes foram incluídos no estudo: A 30 pacientes com SH (21 mulheres e 9 homens; 41,7±11,4 anos e B um grupo controle incluindo 25 pacientes com doenças benignas da coluna (BDS (hérnia de disco lombar ou estável trauma da coluna (8 mulheres e 17 homens; 41,3±14,2 anos. Em um subgrupo de oito pacientes de cada grupo

  9. Genotoxicity testing of Plantago major extracts in somatic cells of Drosophila melanogaster.

    Science.gov (United States)

    Pimenta, Vânia Maria Sartini Dutra; Nepomuceno, Júlio César

    2005-01-01

    Plantago major is used in many parts of the world for the treatment of diseases and to promote the healing of wounds. In the present study, the somatic mutation and recombination test (SMART) in Drosophila melanogaster was used to evaluate the genotoxic activity of an aqueous extract of P. major. The following Drosophila crosses were made: standard (ST) cross, in which virgin flare females (flr3/TM3, Bds) were mated with mwh/mwh males, and high-bioactivation (HB) cross, in which virgin ORR females (ORR/ORR; flr3/TM3, Bds) were mated with mwh/mwh males. Each cross produced two types of descendents, marker-transheterozygous (MH) (mwh +/+ flr3) and balancer-heterozygous (BH) (mwh +/+ TM3, Bds) flies. Three-day-old larvae of both types of descendents were treated with undiluted and diluted (1:1 and 1:2 in water) aqueous extracts of P. major. The extracts were genotoxic in both crosses, producing similar induced frequencies in ST and HB flies. Comparison of the frequencies of wing spots in the BH and MH descendents indicated that recombination was a major response. The results indicate that, under these experimental conditions, aqueous extracts of P. major are genotoxic (recombinagenic). 2004 Wiley-Liss, Inc.

  10. Combustion products of 1,3-butadiene inhibit catalase activity and induce expression of oxidative DNA damage repair enzymes in human bronchial epithelial cells

    Science.gov (United States)

    Kennedy, Christopher H.; Catallo, W. James; Wilson, Vincent L.; Mitchell, James B.

    2012-01-01

    1,3-Butadiene, an important petrochemical, is commonly burned off when excess amounts need to be destroyed. This combustion process produces butadiene soot (BDS), which is composed of a complex mixture of polyaromatic hydrocarbons in particulates ranging in size from butadiene soot ethanol extract (BSEE) on both enzyme activity and expression of proteins involved in the repair of oxidative DNA damage. Catalase was found to be sensitive to BDS as catalase activity was potently diminished in the presence of BSEE. Using Western analysis, both the alpha isoform of human 8-oxoguanine DNA glycosylase (α-hOGG1) and human apurinic/apyrimidinic endonuclease (APE-1) were shown to be significantly overexpressed as compared to untreated controls after exposure of NHBE cells to BSEE. Our results indicate that BSEE is capable of effectively inactivating the antioxidant enzyme catalase, presumably via oxidation of protein amino acids. The presence of oxidized proteins may partially explain the extranuclear fluorescence that is detected when NHBE cells are treated with an organic extract of BDS. Overexpression of both α-hOGG1 and APE-1 proteins following treatment of NHBE cells with BSEE suggests that this mixture causes oxidative DNA damage. PMID:18685817

  11. Estimating Zenith Tropospheric Delays from BeiDou Navigation Satellite System Observations

    Directory of Open Access Journals (Sweden)

    Xin Sui

    2013-04-01

    Full Text Available The GNSS derived Zenith Tropospheric Delay (ZTD plays today a very critical role in meteorological study and weather forecasts, as ZTDs of thousands of GNSS stations are operationally assimilated into numerical weather prediction models. Recently, the Chinese BeiDou Navigation Satellite System (BDS was officially announced to provide operational services around China and its neighborhood and it was demonstrated to be very promising for precise navigation and positioning. In this contribution, we concentrate on estimating ZTD using BDS observations to assess its capacity for troposphere remote sensing. A local network which is about 250 km from Beijing and comprised of six stations equipped with GPS- and BDS-capable receivers is utilized. Data from 5 to 8 November 2012 collected on the network is processed in network mode using precise orbits and in Precise Point Positioning mode using precise orbits and clocks. The precise orbits and clocks are generated from a tracking network with most of the stations in China and several stations around the world. The derived ZTDs are compared with that estimated from GPS data using the final products of the International GNSS Service (IGS. The comparison shows that the bias and the standard deviation of the ZTD differences are about 2 mm and 5 mm, respectively, which are very close to the differences of GPS ZTD estimated using different software packages.

  12. Estimating zenith tropospheric delays from BeiDou navigation satellite system observations.

    Science.gov (United States)

    Xu, Aigong; Xu, Zongqiu; Ge, Maorong; Xu, Xinchao; Zhu, Huizhong; Sui, Xin

    2013-04-03

    The GNSS derived Zenith Tropospheric Delay (ZTD) plays today a very critical role in meteorological study and weather forecasts, as ZTDs of thousands of GNSS stations are operationally assimilated into numerical weather prediction models. Recently, the Chinese BeiDou Navigation Satellite System (BDS) was officially announced to provide operational services around China and its neighborhood and it was demonstrated to be very promising for precise navigation and positioning. In this contribution, we concentrate on estimating ZTD using BDS observations to assess its capacity for troposphere remote sensing. A local network which is about 250 km from Beijing and comprised of six stations equipped with GPS- and BDS-capable receivers is utilized. Data from 5 to 8 November 2012 collected on the network is processed in network mode using precise orbits and in Precise Point Positioning mode using precise orbits and clocks. The precise orbits and clocks are generated from a tracking network with most of the stations in China and several stations around the world. The derived ZTDs are compared with that estimated from GPS data using the final products of the International GNSS Service (IGS). The comparison shows that the bias and the standard deviation of the ZTD differences are about 2 mm and 5 mm, respectively, which are very close to the differences of GPS ZTD estimated using different software packages.

  13. Conceptual Perspectives: Bacterial Antimicrobial Peptide Induction as a Novel Strategy for Symbiosis with the Human Host.

    Science.gov (United States)

    Ghosh, Santosh K; Feng, Zhimin; Fujioka, Hisashi; Lux, Renate; McCormick, Thomas S; Weinberg, Aaron

    2018-01-01

    Human beta defensins (hBDs) are small cationic peptides, expressed in mucosal epithelia and important agents of innate immunity, act as antimicrobial and chemotactic agents at mucosal barriers. In this perspective, we present evidence supporting a novel strategy by which the oral bacterium Fusobacterium nucleatum induces hBDs and other antimicrobial peptides (AMPs) in normal human oral epithelial cells (HOECs) and thereby protects them from other microbial pathogens. The findings stress (1) the physiological importance of hBDs, (2) that this strategy may be a mechanism that contributes to homeostasis and health in body sites constantly challenged with bacteria and (3) that novel properties identified in commensal bacteria could, one day, be harnessed as new probiotic strategies to combat colonization of opportunistic pathogens. With that in mind, we highlight and review the discovery and characterization of a novel lipo-protein, FAD-I ( F usobacterium Associated Defensin Inducer) associated with the outer membrane of F. nucleatum that may act as a homeostatic agent by activating endogenous AMPs to re-equilibrate a dysregulated microenvironment. FAD-I has the potential to reduce dysbiosis-driven diseases at a time when resistance to antibiotics is increasing. We therefore postulate that FAD-I may offer a new paradigm in immunoregulatory therapeutics to bolster host innate defense of vulnerable mucosae, while maintaining physiologically responsive states of inflammation.

  14. Dealing with phraseology in business dictionaries: focus on dictionary functions – not phrases

    Directory of Open Access Journals (Sweden)

    Leroyer, Patrick

    2006-01-01

    Full Text Available The language of written business communication is characterised by the extensive use of phraseology, not only in terms of collocations and idiomatic expressions, but also of standard phrases in prototypical business genres. In any case, the phraseological information should be included in business dictionaries (in the following referred to as BDs in accordance with the planned dictionary functions. Hence, the selection and presentation of the phraseological information should be decided by the lexicographer on the basis of the user needs alone and not on the recommendations of the phraseological literature about lexicographical practice. In this paper, I will firstly explain why lexicography and phraseology, although closely associated in a large number of studies, are quite different disciplines, and how their shared interest for dictionary practice in general is based on radically different views. I will then discuss the dictionary functions of BDs and focus on a number of concepts featuring extensive phraseological solutions to show and argue that dealing with phraseology in BDs should always keep focus on dictionary functions.

  15. Modeling the photo-polarimetric characteristics of brown dwarfs

    Science.gov (United States)

    Sanghavi, Suniti; Millar-Blanchaer, Max; Jensen-Clem, Rebecca; Shporer, Avi; Nilsson, Ricky; Tinyanont, Samaporn; Riedel, Adric; Kataria, Tiffany; Mawet, Dimitri

    2018-01-01

    An envelope of scatterers like free electrons, atoms/molecules, or haze/clouds affect the Stokes vector of radiation emitted by an oblate body.Due to their high rotation rates, brown dwarfs (BDs) are often considerably oblate. We present a conics-based radiative transfer (RT) scheme for computing the disc-resolved and disc-integrated polarized emission of an oblate body like a BD or extrasolar giant planet (EGP) bearing homogenous or patchy clouds. Using this capability, we theoretically examine the photo-polarimetric signal of BDs as a function of the scattering properties of its atmosphere like cloud optical thickness and grain size concurrently with BD properties like oblateness and inclination angle. The effect of oblateness is examined with and without the temperature gradients caused by gravitational darkening, revealing that the latter can considerably amplify the disc-integrated polarization. The signal depends on both oblateness and inclination angle, with the degree of polarization (DoP) increasing with oblateness and decreasing with inclination, a property useful for assessing the exact spatial orientation of the rotation axis in favorable cases. Our examination of BD cloud properties shows a relative blue-shift in the near-infrared (NIR) for increasing droplet size in optically thick clouds - interesting in view of the observed relative brightening in the J-band for L/T transition BDs. For large cloud grains, the polarization decreases sharply, while the transmitted intensity shows a steady increase, thus reducing the DoP.

  16. Vertical Arc for ILC Low Emittance Transport

    International Nuclear Information System (INIS)

    Tenenbaum, P.; Woodley, M.; SLAC

    2005-01-01

    The design and parameters of a vertical arc for the ILC Low Emittance Transport (LET) are reviewed. A 1 TeV CM ILC which relies upon 30 MV/m accelerating cavities with a packing fraction of 65% will require almost 48 km of main linac, which suggests that the total site length including BDS and bunch compressors will be on the order of 53 km. If built in a laser-straight tunnel with the low-energy ends near the surface, and assuming a perfectly spherical ''cue ball'' planetary surface with radius 6370 km, the collider halls will necessarily be 55 meters below grade, as shown in the top plot of Figure 1. Such depths would demand extensive use of deep tunneling, which would potentially drive up the cost and difficulty of ILC construction. An alternate solution is to use discrete vertical arcs at a few locations to allow a ''piecewise straight'' construction in which the depth of the tunnel below grade does not vary by more than a few meters. This approach is shown schematically in the bottom plot of Figure 1. In this Note we consider the issues for a design with one such vertical arc at the 250 GeV/c point (ie, midway down the linac for 1 TeV CM), and a second arc at the entrance to the BDS (ie, the entire BDS lies in one plane, with vertical arcs at each end)

  17. Using binary statistics in Taurus-Auriga to distinguish between brown dwarf formation processes

    Science.gov (United States)

    Marks, M.; Martín, E. L.; Béjar, V. J. S.; Lodieu, N.; Kroupa, P.; Manjavacas, E.; Thies, I.; Rebolo López, R.; Velasco, S.

    2017-08-01

    Context. One of the key questions of the star formation problem is whether brown dwarfs (BDs) form in the manner of stars directly from the gravitational collapse of a molecular cloud core (star-like) or whether BDs and some very low-mass stars (VLMSs) constitute a separate population that forms alongside stars comparable to the population of planets, for example through circumstellar disk (peripheral) fragmentation. Aims: For young stars in Taurus-Auriga the binary fraction has been shown to be large with little dependence on primary mass above ≈ 0.2 M⊙, while for BDs the binary fraction is population synthesis model in which stellar binary formation is universal with a large binary fraction close to unity. Peripheral objects form separately in circumstellar disks with a distinctive initial mass function (IMF), their own orbital parameter distributions for binaries, and small binary fractions, according to observations and expectations from smoothed particle hydrodynamics (SPH) and grid-based computations. A small amount of dynamical processing of the stellar component was accounted for as appropriate for the low-density Taurus-Auriga embedded clusters. Results: The binary fraction declines strongly in the transition region between star-like and peripheral formation, exhibiting characteristic features. The location of these features and the steepness of this trend depend on the mass limits for star-like and peripheral formation. Such a trend might be unique to low density regions, such as Taurus, which host binary populations that are largely unprocessed dynamically in which the binary fraction is large for stars down to M-dwarfs and small for BDs. Conclusions: The existence of a strong decline in the binary fraction - primary mass diagram will become verifiable in future surveys on BD and VLMS binarity in the Taurus-Auriga star-forming region. The binary fraction - primary mass diagram is a diagnostic of the (non-)continuity of star formation along the mass

  18. Are female daycare workers at greater risk of cytomegalovirus infection? A secondary data analysis of CMV seroprevalence between 2010 and 2013 in Hamburg, Germany

    Directory of Open Access Journals (Sweden)

    Stranzinger, Johanna

    2016-04-01

    Full Text Available Background: Close contact with asymptomatic children younger than three years is a risk factor for a primary cytomegalovirus (CMV infection. In pregnant women, such primary infection increases the risk of CMV-induced feto- or embryopathy. Daycare providers have therefore implemented working restrictions for pregnant daycare workers (DCWs in accordance with legislation and guidelines for maternity protection. However, little is known about the infection risk for DCWs. We therefore compared the prevalence of CMV antibodies of pregnant DCWs to that of female blood donors (BDs.Method: In a secondary data analysis, the prevalence of anti-CMV IgG among pregnant DCWs (N=509 in daycare centers (DCCs was compared to the prevalence of female first-time BDs (N=14,358 from the greater region of Hamburg, Germany. Data collection took place between 2010 and 2013. The influence of other risk factors such as age, pregnancies and place of residence was evaluated using logistic regression models. Results: The prevalence of CMV antibodies in pregnant DCWs was higher than in female BDs (54.6 vs 41.5%; OR 1.6; 95%CI 1.3–1.9. The subgroup of BDs who had given birth to at least one child and who lived in the city of Hamburg (N=2,591 had a prevalence of CMV antibodies similar to the prevalence in pregnant DCWs (53.9 vs 54.6%; OR 0.9; 95%CI 0.8–1.2. Age, pregnancy history and living in the center of Hamburg were risk factors for CMV infections.Conclusion: The comparison of pregnant DCWs to the best-matching subgroup of female first-time BDs with past pregnancies and living in the city of Hamburg does not indicate an elevated risk of CMV infection among DCWs. However, as two secondary data sets from convenience samples were used, a more detailed investigation of the risk factors other than place of residence, age and maternity was not possible. Therefore, the CMV infection risk in DCWs should be further studied by taking into consideration the potential preventive

  19. Modeling tropospheric wet delays with national GNSS reference network in China for BeiDou precise point positioning

    Science.gov (United States)

    Zheng, Fu; Lou, Yidong; Gu, Shengfeng; Gong, Xiaopeng; Shi, Chuang

    2017-10-01

    During past decades, precise point positioning (PPP) has been proven to be a well-known positioning technique for centimeter or decimeter level accuracy. However, it needs long convergence time to get high-accuracy positioning, which limits the prospects of PPP, especially in real-time applications. It is expected that the PPP convergence time can be reduced by introducing high-quality external information, such as ionospheric or tropospheric corrections. In this study, several methods for tropospheric wet delays modeling over wide areas are investigated. A new, improved model is developed, applicable in real-time applications in China. Based on the GPT2w model, a modified parameter of zenith wet delay exponential decay wrt. height is introduced in the modeling of the real-time tropospheric delay. The accuracy of this tropospheric model and GPT2w model in different seasons is evaluated with cross-validation, the root mean square of the zenith troposphere delay (ZTD) is 1.2 and 3.6 cm on average, respectively. On the other hand, this new model proves to be better than the tropospheric modeling based on water-vapor scale height; it can accurately express tropospheric delays up to 10 km altitude, which potentially has benefits in many real-time applications. With the high-accuracy ZTD model, the augmented PPP convergence performance for BeiDou navigation satellite system (BDS) and GPS is evaluated. It shows that the contribution of the high-quality ZTD model on PPP convergence performance has relation with the constellation geometry. As BDS constellation geometry is poorer than GPS, the improvement for BDS PPP is more significant than that for GPS PPP. Compared with standard real-time PPP, the convergence time is reduced by 2-7 and 20-50% for the augmented BDS PPP, while GPS PPP only improves about 6 and 18% (on average), in horizontal and vertical directions, respectively. When GPS and BDS are combined, the geometry is greatly improved, which is good enough to get a

  20. Biodesulphurization of gasoline by Rhodococcus erythropolis supported on polyvinyl alcohol.

    Science.gov (United States)

    Fatahi, A; Sadeghi, S

    2017-05-01

    A new biodesulphurization (BDS) method has been considered using Rhodococcus erythropolis supported on polyvinyl alcohol (PVA) for BDS of thiophene as a gasoline sulphur model compound in n-hexane as the solvent, subsequently this biocatalyst has been applied to BDS of gasoline samples. The obtained results according to UV-Spectrophotometer analysis at 240 nm showed that 97·41% of thiophene at the optimum condition of primary concentration 80 mg l -1 , pH = 7, by 0·1 g of biocatalyst in 30°C and after 20 h of contact time has been degraded. These optimum conditions have been applied to gasoline BDS and the biodegradation of gasoline thiophenic compounds have been investigated by gas chromatography-mass spectrometry (GC-MS). According to GC-MS, thiophene and its 2-methyl, 3-methyl and 2- ethyl derivatives had acceptable biodegradation efficiencies of about 26·67, 21·03, 23·62% respectively. Also, benzothiophene that has been detected in a gasoline sample had 38·89% biodegradation efficiency at optimum conditions, so biomodification of PVA by R. erythropolis produces biocatalysts with an active metabolism that facilitates the interaction of bacterial strain with gasoline thiophenic compounds. The morphology and surface functional groups of supported R. erythropolis on PVA have been investigated by scanning electron microscope (SEM) and FT-IR spectroscopy respectively. SEM images suggest some regular layered shape for the supported bacteria. FT-IR spectra indicate a desirable interaction between bacterial cells and polymer supports. Also, the recovery of biocatalyst has been investigated and after three times of using in BDS activity, its biocatalytic ability had no significant decreases. The biomodification of polyvinyl alcohol by Rhodococcus erythropolis described herein produces a new biocatalyst which can be used for significantly reducing the thiophenic compounds of gasoline and other fossil fuels. The immobilization process is to increase the

  1. THE BIOCATALYTIC DESULFURIZATION PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Scott Collins; David Nunn

    2003-10-01

    The analysis of Petro Star diesel sulfur species is complete and a report is attached. Further analytical efforts will concentrate on characterization of diesel fuel, hydrodesulfurized to varying degrees, in order to determine sulfur species that may be problematic to hydrogen treatment and represent potential target substrates for biodesulfurization in a combined HDS-BDS process. Quotes have been received and are being considered for the partial treatment of Petro Star Inc. marine diesel fuel. Direction of research is changing slightly; economic analysis of the hyphenated--BDSHDS, BDS-CED--has shown the highest probability of success to be with a BDS-HDS process where the biodesulfurization precedes hydrodesulfurization. Thus, the microorganisms will be tailored to focus on those compounds that tend to be recalcitrant to hydrodesulfurization and decrease the severity of the hydrodesulfurization step. A separate, detailed justification for this change is being prepared. Research activities have continued in the characterization of the desulfurization enzymes from multiple sources. Genes for all DszA, -B, -C and -D enzymes (and homologs) have been cloned and expressed. Activity determinations, on a variety of substituted benzothiophene and dibenzothiophene substrates, have been carried out and continue. In addition, chemical synthesis efforts have been carried out to generate additional substrates for analytical standards and activity determinations. The generation of a GSSM mutant library of the ''Rhodococcus IGTS8 dszA'' gene has been completed and development of protocols for a high throughput screen to expand substrate specificity are nearing completion. In an effort to obtain improved hosts as biocatalyst, one hundred-thirty ''Rhodococcus'' and related strains are being evaluated for growth characteristics and other criteria deemed important for an optimal biocatalyst strain. We have also begun an effort to generate

  2. Manufacture of pooled platelets in additive solution and storage in an ELX container after an overnight warm temperature hold of platelet-rich plasma.

    Science.gov (United States)

    Alhumaidan, Hiba; Cheves, Tracey; Holme, Stein; Sweeney, Joseph D

    2011-10-01

    The processing of whole blood-derived platelet-rich plasma (PRP) to a platelet concentrate and platelet-poor plasma is currently performed within 8 hours to comply with the requirements to manufacture fresh frozen plasma. Maintaining PRP at room temperature for a longer period can have the advantage of shifting the completion of component manufacture onto day shifts. Pairs of ABO-identical prepooled platelets were manufactured by the PRP method, using the current approach with platelet storage in a CLX HP container (Pall Medical, Covina, CA) and plasma, or a novel approach with an 18- to a 24-hour room temperature hold of the PRP and the manufacture of pooled platelets in a glucose-containing additive solution (AS) and storage in a new ELX container (Pall Medical). Standard in vitro assays were performed on days 2, 5, and 7. The results showed that the AS platelets in ELX have in vitro characteristics that are equivalent or superior to those of the standard product.

  3. Specificity of germination of heteromorphic seeds in four annuals (Salsola L.) at different temperatures in the Junggar basin

    International Nuclear Information System (INIS)

    Ning, L.; Feng, L.H.; Chi, L.Z.; Xia, C.Z.

    2015-01-01

    Salsola L. is a large genus of arid desert plants that are primarily distributed in the Junggar Basin, China. We analysed their ability to adapt to arid habitats by comparing differences in germination characteristics of the species and populations of Salsola affinis C. A. Mey, Salsola korshinskyi Drob., Salsola brachiata Pall. and Salsola nitraria Pall. We classified the 4 species into four types (A, B, C and D) according to seed wing and seed size, and the heteromorphic seeds were incubatedunder different temperature regimes (0/10 degree C, 5/15 degree C, 10/25 degree C and 20/35 degree C). The 4 species had the highest germination rates and germination potential at 0/1 C. Germination rates and potential decreased with increasing temperature. However, the change range of the germination rate among the four species was different. Type A and B seeds of S. affinis, S. nitraria and S. korshinskyi were dominant at all temperatures and decreased with increasing temperature. The germination rate of type C seeds was between that of type A, B and D seeds. D-type seeds had the lowest germination rate and the lowest germination potential under the four temperature regimes among the four species but the differences were not significant. The germination rates of the four types of S. brachiata seeds did not significantly change with temperature. These results suggest that Salsola spp. can germinate continuously from spring to autumn to adapt to moisture fluctuations in the desert. (author)

  4. HYDROGEN PRODUCTION VIA A COMMERCIALLY READY INORGANIC MEMBRANE REACTOR

    Energy Technology Data Exchange (ETDEWEB)

    Paul K.T. Liu

    2004-07-21

    The porous stainless steel substrate commercially available from Pall offers great potential for large-scale membrane based high temperature gas separations. Our proposed project involves the deposition of the M&P carbon molecular sieve-based hydrogen membrane on AccuSep substrate as a membrane to reactor water-gas-shift reaction. However, the AccuSep substrate was originally designed for liquid phase applications . During the 1st half, this commercial substrate has been modified and improved with regard to its surface topography and end seals. The substrate is now suitable for the deposition of the CMS membrane for hydrogen separation according to the characterization we preformed. In addition, 40{angstrom} Al{sub 2}O{sub 3} membrane layers have been deposited on the improved AccuSep substrate successfully. The SEM, EDX and pore size distribution analysis indicate that the 40{angstrom} membrane is extremely thin, and defect free with a narrow pore size distribution around 40{angstrom} primarily. As the above results suggest, we have made significant progress in preparing a high quality nominal 40{angstrom} (actually 50{angstrom}) layer on the Pall substrate. During the 2nd half of Year 1, we will (1) continue this development work with a focus on eliminating the high pore size peak and (2) begin the CMS layer deposition on the 40{angstrom} deposited AccuSep.

  5. PROTOPLANETARY DISK MASSES FROM STARS TO BROWN DWARFS

    International Nuclear Information System (INIS)

    Mohanty, Subhanjoy; Mortlock, Daniel; Greaves, Jane; Pascucci, Ilaria; Apai, Daniel; Scholz, Aleks; Thompson, Mark; Lodato, Giuseppe; Looper, Dagny

    2013-01-01

    We present SCUBA-2 850 μm observations of seven very low mass stars (VLMS) and brown dwarfs (BDs). Three are in Taurus and four in the TW Hydrae Association (TWA), and all are classical T Tauri (cTT) analogs. We detect two of the three Taurus disks (one only marginally), but none of the TWA ones. For standard grains in cTT disks, our 3σ limits correspond to a dust mass of 1.2 M ⊕ in Taurus and a mere 0.2 M ⊕ in the TWA (3-10× deeper than previous work). We combine our data with other submillimeter/millimeter (sub-mm/mm) surveys of Taurus, ρ Oph, and the TWA to investigate the trends in disk mass and grain growth during the cTT phase. Assuming a gas-to-dust mass ratio of 100:1 and fiducial surface density and temperature profiles guided by current data, we find the following. (1) The minimum disk outer radius required to explain the upper envelope of sub-mm/mm fluxes is ∼100 AU for intermediate-mass stars, solar types, and VLMS, and ∼20 AU for BDs. (2) While the upper envelope of apparent disk masses increases with M * from BDs to VLMS to solar-type stars, no such increase is observed from solar-type to intermediate-mass stars. We propose this is due to enhanced photoevaporation around intermediate stellar masses. (3) Many of the disks around Taurus and ρ Oph intermediate-mass and solar-type stars evince an opacity index of β ∼ 0-1, indicating significant grain growth. Of the only four VLMS/BDs in these regions with multi-wavelength measurements, three are consistent with considerable grain growth, though optically thick disks are not ruled out. (4) For the TWA VLMS (TWA 30A and B), combining our 850 μm fluxes with the known accretion rates and ages suggests substantial grain growth by 10 Myr, comparable to that in the previously studied TWA cTTs Hen 3-600A and TW Hya. The degree of grain growth in the TWA BDs (2M1207A and SSPM1102) remains largely unknown. (5) A Bayesian analysis shows that the apparent disk-to-stellar mass ratio has a roughly

  6. Evaluation of small wind turbines in distributed arrangement as sustainable wind energy option for Barbados

    International Nuclear Information System (INIS)

    Bishop, Justin D.K.; Amaratunga, Gehan A.J.

    2008-01-01

    The island of Barbados is 99% dependent on fossil fuel imports to satisfy its energy needs, which is unsustainable. This study proposes a 10 MW distributed wind energy scheme using micro wind turbines (WT) of horizontal (HAWT) and vertical axis (VAWT) configurations. These units are rated less than 500 W, and the scheme is hereafter referred to as mWT10. mWT10 is compared to the proposed 10 MW medium WT farm by the Barbados Light and Power Company (BL and P). The economic bottom line is the levelized cost of electricity (LCOE). The results highlight the BL and P proposal as the best economic option at BDS$0.19 per kWh, while that of both mWT10 configurations exceeds the conventional cost of BDS$0.25 by two to nine times. This is attributed to significantly higher relative installation and operational costs. However, the financial gap between mWT10 LCOE and the retail price of electricity is much smaller due to a large fuel surcharge passed on to each customer. Annual additional benefits of using wind energy include: greenhouse gas emissions savings of 6-23 kt of carbon dioxide; and anavoided fuel costs of BDS$1.5-5.3 million. The distributed mWT10 using HAWTs competes directly with the BL and P farm, however, it provides these benefits without the visual or ecological impacts of the larger machines. Conversely, VAWTs have features that favour a visually discrete and widely repeatable scheme but suffer relatively high costs. Therefore, this study illustrates the great potential of small wind turbines to be competitive with conventional wind farms, thus challenging the small wind industry to meet its potential by producing reliable and robust machines at lower cost. (author)

  7. SU-E-T-570: Management of Radiation Oncology Patients with Cochlear Implant and Other Bionic Devices in the Brain and Head and Neck Regions

    International Nuclear Information System (INIS)

    Guo, F.Q; Chen, Z; Nath, R

    2014-01-01

    Purpose: To investigate the current status of clinical usage of cochlear implant (CI) and other bionic devices (BD) in the brain and head and neck regions (BH and N) and their management in patients during radiotherapy to ensure patient health and safety as well as optimum radiation delivery. Methods: Literature review was performed with both CIs and radiotherapy and their variants as keywords in PubMed, INSPEC and other sources. The focus was on CIs during radiotherapy, but it also included other BDs in BHȦN, such as auditory brainstem implant, bionic retinal implant, and hearing aids, among others. Results: Interactions between CIs and radiation may cause CIs malfunction. The presence of CIs may also cause suboptimum dose distribution if a treatment plan was not well designed. A few studies were performed for the hearing functions of CIs under irradiations of 4 MV and 6 MV x-rays. However, x-rays with higher energies (10 to 18 MV) broadly used in radiotherapy have not been explored. These higher energetic beams are more damaging to electronics due to strong penetrating power and also due to neutrons generated in the treatment process. Modern CIs are designed with more and more complicated integrated circuits, which may be more susceptible to radiation damage and malfunction. Therefore, careful management is important for safety and treatment outcomes. Conclusion: Although AAPM TG-34, TG-63, and TG-203 (update of TG-34, not published yet) reports may be referenced for management of CIs and other BDs in the brain and H and N regions, a site- and device-specified guideline should be developed for CIs and other BDs. Additional evaluation of CI functions under clinically relevant set-ups should also be performed to provide clinicians with better knowledge in clinical decision making

  8. SU-E-T-570: Management of Radiation Oncology Patients with Cochlear Implant and Other Bionic Devices in the Brain and Head and Neck Regions

    Energy Technology Data Exchange (ETDEWEB)

    Guo, F.Q; Chen, Z; Nath, R [Yale New Haven Hospital, New Haven, CT (United States); Yale UniversitySchool of Medicine, New Haven, CT (United States)

    2014-06-01

    Purpose: To investigate the current status of clinical usage of cochlear implant (CI) and other bionic devices (BD) in the brain and head and neck regions (BH and N) and their management in patients during radiotherapy to ensure patient health and safety as well as optimum radiation delivery. Methods: Literature review was performed with both CIs and radiotherapy and their variants as keywords in PubMed, INSPEC and other sources. The focus was on CIs during radiotherapy, but it also included other BDs in BHȦN, such as auditory brainstem implant, bionic retinal implant, and hearing aids, among others. Results: Interactions between CIs and radiation may cause CIs malfunction. The presence of CIs may also cause suboptimum dose distribution if a treatment plan was not well designed. A few studies were performed for the hearing functions of CIs under irradiations of 4 MV and 6 MV x-rays. However, x-rays with higher energies (10 to 18 MV) broadly used in radiotherapy have not been explored. These higher energetic beams are more damaging to electronics due to strong penetrating power and also due to neutrons generated in the treatment process. Modern CIs are designed with more and more complicated integrated circuits, which may be more susceptible to radiation damage and malfunction. Therefore, careful management is important for safety and treatment outcomes. Conclusion: Although AAPM TG-34, TG-63, and TG-203 (update of TG-34, not published yet) reports may be referenced for management of CIs and other BDs in the brain and H and N regions, a site- and device-specified guideline should be developed for CIs and other BDs. Additional evaluation of CI functions under clinically relevant set-ups should also be performed to provide clinicians with better knowledge in clinical decision making.

  9. Spin transport at the international linear collider and its impact on the measurement of polarization

    Energy Technology Data Exchange (ETDEWEB)

    Beckmann, Moritz

    2013-12-15

    At the planned International Linear Collider (ILC), the longitudinal beam polarization needs to be determined with an unprecedented precision. For that purpose, the beam delivery systems (BDS) are equipped with two laser Compton polarimeters each, which are foreseen to achieve a systematic uncertainty of {<=} 0.25 %. The polarimeters are located 1.6 km upstream and 150 m downstream of the e{sup +}e{sup -} interaction point (IP). The average luminosity-weighted longitudinal polarization P{sup lumi}{sub z}, which is the decisive quantity for the experiments, has to be determined from these measurements with the best possible precision. Therefore, a detailed understanding of the spin transport in the BDS is mandatory to estimate how precise the longitudinal polarization at the IP is known from the polarimeter measurements. The envisaged precision for the propagation of the measurement value is {<=} 0.1 %. This thesis scrutinizes the spin transport in view of the achievable precision. A detailed beamline simulation for the BDS has been developed, including the simulation of the beam-beam collisions at the IP. The following factors which might limit the achievable precision is investigated: a variation of the beam parameters, the beam alignment precision at the polarimeters and the IP, the bunch rotation at the IP, the detector magnets, the beam-beam collisions, the emission of synchrotron radiation and misalignments of the beamline elements. In absence of collisions, a precision of 0.085% on the propagation of the measured longitudinal polarization has been found achievable. This result however depends mainly on the presumed precisions for the parallel alignment of the beam at the polarimeters and for the alignment of polarization vector. In presence of collisions, the measurement at the downstream polarimeter depends strongly on the intensity of the collision and the size of the polarimeter laser spot. Therefore, a more detailed study of the laser-bunch interaction is

  10. FIRST DETECTION OF THERMAL RADIOJETS IN A SAMPLE OF PROTO-BROWN DWARF CANDIDATES

    Energy Technology Data Exchange (ETDEWEB)

    Morata, Oscar [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China); Palau, Aina; González, Ricardo F. [Centro de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, P.O. Box 3-72, 58090 Morelia, Michoacán, México (Mexico); Gregorio-Monsalvo, Itziar de [Joint ALMA Observatory (JAO), Alonso de Córdova 3107, Vitacura, Santiago (Chile); Ribas, Álvaro [European Space Astronomy Centre (ESA), P.O. Box 78, E-28691 Villanueva de la Cañada, Madrid (Spain); Perger, Manuel [Institut de Ciències de l’Espai (CSIC-IEEC), Campus UAB—Facultat de Ciències, Torre C5—parell 2, E-08193 Bellaterra, Catalunya (Spain); Bouy, Hervé; Barrado, David; Huélamo, Nuria; Morales-Calderón, María [Centro de Astrobiología, INTA-CSIC, Dpto.Astrofísica, ESAC Campus, P.O. Box 78, E-28691 Villanueva de la Cañada, Madrid (Spain); Eiroa, Carlos [Departamento de Física Teórica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Bayo, Amelia, E-mail: omorata@asiaa.sinica.edu.tw [Max Planck Institut für Astronomie, Königstuhl 17, D-69117, Heidelberg (Germany); and others

    2015-07-01

    We observed with the Jansky Very Large Array at 3.6 and 1.3 cm a sample of 11 proto-brown dwarf (BD) candidates in Taurus in a search for thermal radio jets driven by the most embedded BDs. We detected for the first time four thermal radio jets in proto-BD candidates. We compiled data from UKIDSS, 2MASS, Spitzer, WISE, and Herschel to build the spectral energy distribution (SED) of the objects in our sample, which are similar to typical Class I SEDs of young stellar objects (YSOs). The four proto-BD candidates driving thermal radio jets also roughly follow the well-known trend of centimeter luminosity against bolometric luminosity determined for YSOs, assuming they belong to Taurus, although they present some excess of radio emission compared to the known relation for YSOs. Nonetheless, we are able to reproduce the flux densities of the radio jets modeling the centimeter emission of the thermal radio jets using the same type of models applied to YSOs, but with corresponding smaller stellar wind velocities and mass-loss rates, and exploring different possible geometries of the wind or outflow from the star. Moreover, we also find that the modeled mass outflow rates for the bolometric luminosities of our objects agree reasonably well with the trends found between the mass outflow rates and bolometric luminosities of YSOs, which indicates that, despite the “excess” centimeter emission, the intrinsic properties of proto-BDs are consistent with a continuation of those of very low-mass stars to a lower mass range. Overall, our study favors the formation of BDs as a scaled-down version of low-mass stars.

  11. Age, puberty, body dissatisfaction, and physical activity decline in adolescents. Results of the German Health Interview and Examination Survey (KiGGS

    Directory of Open Access Journals (Sweden)

    Finne Emily

    2011-10-01

    Full Text Available Abstract Background Physical activity (PA shows a marked decline during adolescence. Some studies have pointed to pubertal status or timing as possible PA determinants in this age group. Furthermore, it was supposed that the impact of pubertal changes on PA might be mediated by psychological variables like body dissatisfaction (BDS. Methods The 11- to 17-year-old subsample of the German Health Interview and Examination Survey (KiGGS was used (n = 6 813; 51.3% male, response rate = 66.6%. Through sex-specific sequential multinomial logistic regressions we analysed the univariate and independent associations of chronological age, absolute pubertal status, relative pubertal timing, and BDS with the frequency of PA. Results Chronological age showed a significantly negative association with PA in both sexes, independent of puberty. The odds of inactivity in contrast to nearly daily PA increased about 70% in boys and 35% in girls for each year of age, respectively. Adjusted for age and other possible confounders, inactivity was significantly less likely for boys in late pubertal stages (OR = 0.27, 95% CI = 0.09-0.78. The risk of inactivity was more than doubled in boys maturing earlier than peers in terms of relative pubertal timing (OR = 2.20, 95% CI = 1.36-3.56. No clear significant puberty effects were found in girls, but the inactivity was more likely for those with irregular menstruation (OR = 1.71, 95% CI = 1.06-2.75. BDS also contributed to the prediction of PA in both sexes. It partially mediated puberty effects in boys but not in girls. Conclusions Overall, chronological age was a far more important predictor of PA in German adolescents than absolute pubertal status or relative pubertal timing. Further possible explanatory variables like sociocultural influences, social support or increasing time requirements for education should be analysed in conjunction with chronological age in future studies.

  12. The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model.

    Science.gov (United States)

    Scott, Katherine A; Dalgleish, Angus G; Liu, Wai M

    2014-12-01

    High-grade glioma is one of the most aggressive cancers in adult humans and long-term survival rates are very low as standard treatments for glioma remain largely unsuccessful. Cannabinoids have been shown to specifically inhibit glioma growth as well as neutralize oncogenic processes such as angiogenesis. In an attempt to improve treatment outcome, we have investigated the effect of Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) both alone and in combination with radiotherapy in a number of glioma cell lines (T98G, U87MG, and GL261). Cannabinoids were used in two forms, pure (P) and as a botanical drug substance (BDS). Results demonstrated a duration- and dose-dependent reduction in cell viability with each cannabinoid and suggested that THC-BDS was more efficacious than THC-P, whereas, conversely, CBD-P was more efficacious than CBD-BDS. Median effect analysis revealed all combinations to be hyperadditive [T98G 48-hour combination index (CI) at FU50, 0.77-1.09]. Similarly, pretreating cells with THC-P and CBD-P together for 4 hours before irradiation increased their radiosensitivity when compared with pretreating with either of the cannabinoids individually. The increase in radiosensitivity was associated with an increase in markers of autophagy and apoptosis. These in vitro results were recapitulated in an orthotopic murine model for glioma, which showed dramatic reductions in tumor volumes when both cannabinoids were used with irradiation (day 21: 5.5 ± 2.2 mm(3) vs. 48.7 ± 24.9 mm(3) in the control group; P < 0.01). Taken together, our data highlight the possibility that these cannabinoids can prime glioma cells to respond better to ionizing radiation, and suggest a potential clinical benefit for glioma patients by using these two treatment modalities. ©2014 American Association for Cancer Research.

  13. The inter-observer variability of breast density scoring between mammography technologists and breast radiologists and its effect on the rate of adjuvant ultrasound.

    Science.gov (United States)

    Mazor, Roei D; Savir, Avital; Gheorghiu, David; Weinstein, Yuliana; Abadi-Korek, Ifat; Shabshin, Nogah

    2016-05-01

    This study assesses the inter-observer variability of mammographic breast density scoring (BDS) between technologists and radiologists and evaluates the effect of technologist patient referral on the load of adjuvant ultrasounds. In this IRB approved study, a retrospective analysis of 503 prospectively acquired, random mammograms was performed between January and March 2014. Each mammogram was evaluated for BDS independently and blindly by both the performing technologist and the interpreting radiologist. Statistical calculation of the Spearman correlation coefficient and weighted kappa were obtained to evaluate the inter-observer variability between technologists and radiologists and to examine whether it relates to the technologist's seniority or women's age. The effect on the load of adjuvant ultrasounds was evaluated. 10 mammography technologists and 7 breast radiologists participated in this study. BDS agreement levels between technologists and radiologists were in the fair to moderate range (kappa values: 0.3-0.45, Spearman coefficient values: 0.59-0.65). The technologists markedly over-graded the density compared to the radiologists in all the subsets evaluated. Comparison between low and high-density groups demonstrated a similar trend of over-grading by technologists, who graded 51% of the women as having dense breasts (scores 3-4) compared to 27% of the women graded as such by the radiologists. This trend of over grading breast density by technologists was unrelated to the women's age or to the technologists' seniority. Mammography technologists over-grade breast density. Technologists' referral to an adjuvant ultrasound leads to redundant ultrasound studies, unnecessary breast biopsies, costs and increased patient anxiety. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  14. Robust surface reconstruction by design-guided SEM photometric stereo

    Science.gov (United States)

    Miyamoto, Atsushi; Matsuse, Hiroki; Koutaki, Gou

    2017-04-01

    We present a novel approach that addresses the blind reconstruction problem in scanning electron microscope (SEM) photometric stereo for complicated semiconductor patterns to be measured. In our previous work, we developed a bootstrapping de-shadowing and self-calibration (BDS) method, which automatically calibrates the parameter of the gradient measurement formulas and resolves shadowing errors for estimating an accurate three-dimensional (3D) shape and underlying shadowless images. Experimental results on 3D surface reconstruction demonstrated the significance of the BDS method for simple shapes, such as an isolated line pattern. However, we found that complicated shapes, such as line-and-space (L&S) and multilayered patterns, produce deformed and inaccurate measurement results. This problem is due to brightness fluctuations in the SEM images, which are mainly caused by the energy fluctuations of the primary electron beam, variations in the electronic expanse inside a specimen, and electrical charging of specimens. Despite these being essential difficulties encountered in SEM photometric stereo, it is difficult to model accurately all the complicated physical phenomena of electronic behavior. We improved the robustness of the surface reconstruction in order to deal with these practical difficulties with complicated shapes. Here, design data are useful clues as to the pattern layout and layer information of integrated semiconductors. We used the design data as a guide of the measured shape and incorporated a geometrical constraint term to evaluate the difference between the measured and designed shapes into the objective function of the BDS method. Because the true shape does not necessarily correspond to the designed one, we use an iterative scheme to develop proper guide patterns and a 3D surface that provides both a less distorted and more accurate 3D shape after convergence. Extensive experiments on real image data demonstrate the robustness and effectiveness

  15. Rapid on-site detection of ephedrine and its analogues used as adulterants in slimming dietary supplements by TLC-SERS.

    Science.gov (United States)

    Lv, Diya; Cao, Yan; Lou, Ziyang; Li, Shujin; Chen, Xiaofei; Chai, Yifeng; Lu, Feng

    2015-02-01

    Ephedrine and its analogues are in the list of prohibited substance in adulteration to botanical dietary supplements (BDS) for their uncontrollable stimulating side effects. However, they were always adulterated illegally in BDS to promote losing weight. In order to avoid detection, various kinds of ephedrine analogues were added rather than ephedrine itself. This has brought about great difficulties in authentication of BDS. In this study, we put forward for the first time a method which combined thin-layer chromatography (TLC) and surface-enhanced Raman scattering (SERS) to directly identify trace adulterant. Ephedrine, pseudoephedrine, methylephedrine, and norephedrine were mixed and used in this method to develop an analytical model. As a result, the four analogues were separated efficiently in TLC analysis, and trace-components and low-background SERS detection was realized. The limit of detection (LOD) of the four analogues was 0.01 mg/mL. Eight common Raman peaks (△υ = 620, 1003, 1030, 1159, 1181, 1205, 1454, 1603 cm(-1)) were extracted experimentally and statistically to characterize the common feature of ephedrine analogues. A TLC-SERS method coupled with common-peak model was adopted to examine nine practical samples, two of which were found to be adulterated with ephedrine analogues. Identification results were then confirmed by UPLC-QTOF/MS analysis. The proposed method was simple, rapid, and accurate and can also be employed to trace adulterant identification even when there are no available reference derivatives on-site or unknown types of ephedrine analogues are adulterated.

  16. Working memory span in Persian-speaking children with speech sound disorders and normal speech development.

    Science.gov (United States)

    Afshar, Mohamad Reza; Ghorbani, Ali; Rashedi, Vahid; Jalilevand, Nahid; Kamali, Mohamad

    2017-10-01

    The aim of this study was to compare working memory span in Persian-speaking preschool children with speech sound disorder (SSD) and their typically speaking peers. Additionally, the study aimed to examine Non-Word Repetition (NWR), Forward Digit Span (FDS) and Backward Digit Span (BDS) in four groups of children with varying severity levels of SSD. The participants in this study comprised 35 children with SSD and 35 typically developing (TD) children -matched for age and sex-as a control group. The participants were between the age range of 48 and 72 months. Two components of working memory including phonological loop and central executive were compared between two groups. We used two tasks (NWR and FDS) to assess phonological loop component, and one task (BDS) to assess central executive component. Percentage of correct consonants (PCC) was used to calculate the severity of SSD. Significant differences were observed between the two groups in all tasks that assess working memory (p memory between the various severity groups indicated significant differences between different severities of both NWR and FDS tasks among the SSD children (p  0.05). The result showed that PCC scores in TD children were associated with NWR (p  0.05). The working memory skills were weaker in SSD children, in comparison to TD children. In addition, children with varying levels of severity of SSD differed in terms of NWR and FSD, but not BDS. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Age, puberty, body dissatisfaction, and physical activity decline in adolescents. Results of the German Health Interview and Examination Survey (KiGGS).

    Science.gov (United States)

    Finne, Emily; Bucksch, Jens; Lampert, Thomas; Kolip, Petra

    2011-10-27

    Physical activity (PA) shows a marked decline during adolescence. Some studies have pointed to pubertal status or timing as possible PA determinants in this age group. Furthermore, it was supposed that the impact of pubertal changes on PA might be mediated by psychological variables like body dissatisfaction (BDS). The 11- to 17-year-old subsample of the German Health Interview and Examination Survey (KiGGS) was used (n = 6 813; 51.3% male, response rate = 66.6%). Through sex-specific sequential multinomial logistic regressions we analysed the univariate and independent associations of chronological age, absolute pubertal status, relative pubertal timing, and BDS with the frequency of PA. Chronological age showed a significantly negative association with PA in both sexes, independent of puberty. The odds of inactivity in contrast to nearly daily PA increased about 70% in boys and 35% in girls for each year of age, respectively. Adjusted for age and other possible confounders, inactivity was significantly less likely for boys in late pubertal stages (OR = 0.27, 95% CI = 0.09-0.78). The risk of inactivity was more than doubled in boys maturing earlier than peers in terms of relative pubertal timing (OR = 2.20, 95% CI = 1.36-3.56). No clear significant puberty effects were found in girls, but the inactivity was more likely for those with irregular menstruation (OR = 1.71, 95% CI = 1.06-2.75). BDS also contributed to the prediction of PA in both sexes. It partially mediated puberty effects in boys but not in girls. Overall, chronological age was a far more important predictor of PA in German adolescents than absolute pubertal status or relative pubertal timing. Further possible explanatory variables like sociocultural influences, social support or increasing time requirements for education should be analysed in conjunction with chronological age in future studies.

  18. Effect of meta-carborane on segmental dynamics in a bimodal Poly(dimethylsiloxane) network

    Energy Technology Data Exchange (ETDEWEB)

    Lewicki, J; Maxwell, R S; Patel, M; Herberg, J; Swain, A C; Liggat, J; Pethrick, R

    2008-06-11

    Bimodal networks of polydimethylsiloxane (PDMS) filled with varying amounts of icosahedral meta-carborane (m-CB) have been developed and characterized by broadband dielectric spectroscopy (BDS) and static {sup 1}H Multiple Quantum Nuclear Magnetic Resonance (MQ NMR). Both BDS and MQ NMR showed evidence for a decrease in the polymer chain dynamics. BDS spectra quantified a normal-mode relaxation near 40 Hz at 40 C. The frequency maximum observed for filled samples decreased with increasing m-CB content until contents greater than 5 wt. %. The width of the relaxation spectrum increased with the addition of small quantities of filler and decreased with filler contents greater that 5 wt. %. Agglomeration effects were observed at loadings greater than 5 wt % as manifest by the onset of low frequency Maxwell-Wagner-Sillars (MWS) processes. The MQ NMR data allowed the characterization of distributions of the residual dipolar couplings, <{Omega}{sub d}> and thus in the dynamic order parameter, Sb, consistent with the bimodal network architecture expected from the synthesis protocol used. Upon addition of less than 10 wt.% m-CB filler, the mean <{Omega}{sub d}> for the longer chains increased by 46% and the width of the distribution increased by 33%. The mean <{Omega}{sub d}> for the shorter chains increased by much less, indicative of preferential dispersion of the filler particles in the long chain domains of the network structure. We conclude that the mechanism of reinforcement is likely a free volume space filling at low loadings transitioning to complex molecular filler and polymer chain interaction phenomena at higher loadings.

  19. There is No Evidence on the Effect of the Attachment System on Implant Survival Rate, Overdenture Maintenance, or Patient Satisfaction.

    Science.gov (United States)

    Alqutaibi, Ahmed Yaseen

    2015-12-01

    Attachment systems for mandibular implant overdentures: a systematic review. Kim HY, Lee JY, Shin SW, Bryant SR.J Advanced Prosthodont 2012;4(4):197-203. Ahmed Yaseen Alqutaibi, BDS, MDSc, PhD(c) To address treatment outcomes depending on attachment systems for two-implant mandibular-supported overdentures in terms of (1) implant survival rate, (2) prosthetic maintenance and complications, and (3) patient satisfaction. Systematic review Level 2: Limited-quality, patient-oriented evidence Grade B: Inconsistent, limited-quality patient-oriented evidence. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. CLIC Muon Sweeper Design

    CERN Document Server

    Aloev, A.; Gatignon, L.; Modena, M.; Pilicer, B.; Tapan, I.

    2016-01-01

    There are several background sources which may affect the analysis of data and detector performans at the CLIC project. One of the important background source is halo muons, which are generated along the beam delivery system (BDS), for the detector performance. In order to reduce muon background, magnetized muon sweepers have been used as a shielding material that is already described in a previous study for CLIC [1]. The realistic muon sweeper has been designed with OPERA. The design parameters of muon sweeper have also been used to estimate muon background reduction with BDSIM Monte Carlo simulation code [2, 3].

  1. Newton-Hooke Limit of Beltrami-de Sitter Spacetime, Principles of Galilei-Hooke's Relativity and Postulate on Newton-Hooke Universal Time

    OpenAIRE

    Huang, Chao-Guang; Guo, Han-Ying; Tian, Yu; Xu, Zhan; Zhou, Bin

    2004-01-01

    Based on the Beltrami-de Sitter spacetime, we present the Newton-Hooke model under the Newton-Hooke contraction of the $BdS$ spacetime with respect to the transformation group, algebra and geometry. It is shown that in Newton-Hooke space-time, there are inertial-type coordinate systems and inertial-type observers, which move along straight lines with uniform velocity. And they are invariant under the Newton-Hooke group. In order to determine uniquely the Newton-Hooke limit, we propose the Gal...

  2. Recent Theoretical Developments in CP Violation in the B System

    CERN Document Server

    Fleischer, Robert

    2000-01-01

    After a brief review of the present status of the standard methods to extract CKM phases from CP-violating effects in non-leptonic B-decays, an overview of recent theoretical developments in this field is given, including extractions of $\\gamma$ from $B\\to\\pi K$ and $B_{s(d)}\\to J/\\psi K_S$ decays, a simultaneous determination of $\\beta$ and $\\gamma$, which is provided by the modes $B_d\\to \\pi^+ \\pi^-$ and $B_s\\to K^+ K^-$, and extractions of CKM phases from angular distributions of certain $B_{d,s}$ decays, such as $B_d\\to J/\\psi

  3. Practices of spatial governance in regional and city-region making

    DEFF Research Database (Denmark)

    Galland, Daniel; Larsen, Peter Wilgaard

    and public stakeholders. Since the implementation of the Danish municipal reform in 2007, this partnership-oriented body has advanced and implemented business development strategies (BDS) aimed at improving local conditions for economic growth. • Municipal Contact Councils (Kommunekontaktråd or KKR...... on spatial governance with a focus on England, whereby the evolution and transformation of English planning is portrayed as follows: “Once a system for regulating and balancing change in the built and natural environments in the public interest, planning now finds itself facilitating development and economic...

  4. Unexplored areas of psychotherapy in bipolar disorder.

    Science.gov (United States)

    Popovic, Dina; Yildiz, Ayşegül; Murphy, Paula; Colom, Francesc

    2014-01-01

    Several psychological interventions-including group psychoeducation, family-focused psychoeducation, and interpersonal social-rhythm therapy-have demonstrated prophylactic efficacy as an adjunct to medication in bipolar disorders (BDs). The field of psychological interventions for BD has experienced impressive progress over the last 15 years. Certain unexplored areas, however, require further research in order to establish the full potential of psychological interventions for BD. Such research should focus, among other things, on cognitive impairment associated with BD, BD in the elderly, comorbid anxiety disorders and other comorbidities, the treatment of BD in pregnant women, and the improvement of patients' overall physical health.

  5. Gasoline Biodesulfurization DE-FC07-97ID13570 FINAL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Pienkos, Philip T.

    2002-01-15

    Nine strains were identified to grow with gasoline as sole sulfur source. Two different genes were cloned from Gordonia terrae KGB1 and tested for the ability to support gasoline BDS. The first of these, fmoA, was cloned by screening a KGB1 gene library for the ability to convert indole to indigo (a sulfur-regulated capability in KGB1). The fmoA gene was overexpressed in a gasoline tolerant strain of Pseudomonas putida PpG1 and the recombinant strain was shown to convert thiophene to a dimer of thiophene sulfoxide at rates nearly two orders of magnitude higher than KGB1 could catalyze the reaction. Despite this high activity the recombinant PpG1 was unable to demonstrate any activity against gasoline either in shake flask or in bench-scale gasoline BDS bioreactor. A second gene (toeA) was cloned from KGB1 and shown to support growth of Rhodococcus erythropolis JB55 on gasoline. The toeA gene was also identified in another gasoline strain T. wratislaviensis EMT4, and was identified as a homolog of dszA from R. erythropolis IGTS8. Expression of this gene in JB55 supported conversion of DBTO2 (the natural substrate for DszA) to HPBS, but activity against gasoline was low and BDS results were inconsistent. It appeared that activity was directed against C2- and C3-thiophenes. Efforts to increase gene expression by plasmid manipulation, by addition of flavin reductase genes, or by expression in PpG1 were unsuccessful. The DszC protein (DBT monooxygenase) from IGTS8 has very little activity against the sulfur compounds in gasoline, but a mutant enzyme with a substitution of phenylalanine for valine at position 261 was shown to have an altered substrate range. This alteration resulted in increased activity against gasoline, with activity towards mainly C3- and C4-thiophenes and benzothiophene. A mutant library of dszB was constructed by RACHITT (W. C. Coco et al., DNA shuffling method for generating highly recombined genes and evolved enzymes. 2001. Nature Biotech. 19

  6. Tuning of the Compact Linear Collider Beam Delivery System

    CERN Document Server

    Garcia, H; Inntjore Levinsen, Y; Latina, A; Tomas, R; Snuverink, J

    2014-01-01

    Tuning the Compact Linear Collider (CLIC) BeamDelivery System (BDS), and in particular the Final Focus (FF), is a challenging task. In simulations without misalignments, the goal is to reach 120%o f the nominal luminosity target, in order to allow for 10% loss due to static imperfections, and another 10% loss from dynamic imperfections. Various approaches have been considered to correct the magnet misalignments, including 1-1 correction, Dispersion Free Steering (DFS), and several minimization methods utilizing multipole movers. In this paper we report on the recent advancements towards a feasible tuning approach that reaches the required luminosity target.

  7. Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice.

    Science.gov (United States)

    Huang, Qiling; Ma, Xiaomeng; Zhu, Dong Liang; Chen, Li; Jiang, Ying; Zhou, Linli; Cen, Lei; Pi, Rongbiao; Chen, Xiaohong

    2015-07-15

    Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that TGP can reduce the severity and progression of EAE in C57 BL/6 mice. In addition, TGP also down-regulated the Th1/Th17 inflammatory response and prevented the reduced expression of brain-derived neurotrophic factor and 2',3'-cyclic nucleotide 3'-phosphodiesterase of EAE. These findings suggest that TGP could be a potential therapeutic agent for MS. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. [Fungi isolated from diseased medicinal plants].

    Science.gov (United States)

    Sato, T; Matsuhashi, M; Iida, O

    1992-01-01

    One hundred and forty-four fungal isolates were obtained from diseased Paeonia albiflora Pall. var. trichocarpa Bung., Astragalus membranaceus Bung., Lithospermum erythrorhizon Sieb. et Zucc., Ledebouriella seseloides Wolff and Bupleurum falcatum L. which were collected in the test field of Tsukuba Medicinal Plant Research Station, National Institute of Hygienic Sciences. Most of them were identified into 15 genera containing 8 species. Fungal species presumed to be pathogens of the host plants were as follows: Cladosporium paeoniae, Pestalotia paeoniicola, Glomerella cingulata, Hainesia lythri, Guignardia sp. and Alternaria sp. from P. albiflora, Fusarium spp., Rhizoctonia spp. and Neocosmospora vasinfecta from A. membranaceus, Colletotrichum gloeosporioides from L. erythrorhizon, Rhizoctonia sp., Fusarium spp., Phoma sp. and Pyrenochaeta sp. from L. seseloides, and Fusarium sp., Alternaria alternata, Phyllosticta sp., Phoma sp., Phomopsis sp. and C. gloeosporioides from B. falcatum. Roots of B. falcatum were found to be parasitized by Meloidogyne sp.

  9. Rare species of the genus Oxytropis DC. (Fabaceae) from the flora of the Republic of Bashkortostan under cultivation within the city of Ufa

    Science.gov (United States)

    Maslova, N. V.; Elizaryeva, O. A.; Galikeeva, G. M.; Tyutyunova, N. M.

    2018-01-01

    This paper presents the results of investigations introducing eight rare species of the genus Oxytropis DC. from the flora of the Republic of Bashkortostan into the city of Ufa. Seven species are characterized as promising ornamental plants. According to the integrated evaluation scale of introduction effectiveness based on seven indices, two species were considered as very promising (O. spicata (Pall.) O. et B. Fedtsch., O. knjazevii Vasjukov), five species as promising (O. approximata Less., O. baschkirensis Knjasev, O. hippolyti Boriss., O. gmelinii Boriss., O. kungurensis Knjasev) and one species as non-promising (O. sordida (Willd.) Pers.). The ornamental quality assessment of rare species of the genus Oxytropis based on ten indices showed that these species can be used to create ornamental compositions in the landscape design style.

  10. Guiding young adults at risk

    DEFF Research Database (Denmark)

    Andreasen, Karen Egedal; Rasmussen, Palle Damkjær; Ydesen, Christian

    2016-01-01

    Karen Egedal Andreasen, Palle Rasmussen and Christian Ydesen question in their article, how to guide youth in danger of being marginalised or excluded from society in general and the labour market in particular. They analyse the guidance dimension in the youth in development project as described...... in the project and by the youths participating in the project. The project was designed to facilitate and support transition to an adult life by giving participants social support, feedback, experiences, room for reflection and feeling of acceptance and inclusion. In Denmark all social work with young people...... at risk involves guidance to “the right path”, since individual guidance seems to be the key asset in mobilizing young person’s needs and experiences. The article indicates important elements in the guidance of youth at risk, such as psychological intervention and personal support, support from...

  11. Remoção de matéria orgânica e sólidos suspensos por nova configuração de biofiltro aeróbio submerso no pós-tratamento de efluente de reator UASB Removal of organic matter and suspended solids by a new configuration of biological aerated filter in the post-treatment of UASB reactor effluent

    Directory of Open Access Journals (Sweden)

    Saulo Varela Della Giustina

    2010-09-01

    Full Text Available O pós-tratamento de efluentes de reatores anaeróbios é um processo necessário para o atendimento dos padrões de emissão. Os resultados aqui apresentados mostram a viabilidade de uso de uma nova configuração de biofiltro aeróbio submerso (BAS no pós-tratamento desses efluentes. Os BAS multiestágio apresentam uma câmara anaeróbia (V=12,6L, seguido de uma câmara aeróbia (V=30L e uma câmara anóxica (V=26,4L, todas em série (V total=70L. Neste estudo, foi analisada a remoção de sólidos suspensos (SS, DQO e DBO5. Foram utilizados três BAS multi-estágio preenchidos com três diferentes materiais-suporte: tampas e gargalos PET (165m²/m³, pedra britada n. 4 (50m²/m³ e anéis Pall 1,5'' (135m²/m³. Os reatores foram operados com valores de tempos de detenção hidráulicas (TDH de 4,1, 8,2 e 12,3 horas, e três taxas de aplicação superficial (TAS (21, 12 e 8m³/m².d. A associação dos reatores UASB+BAS possibilitou remoções de DQO total superiores a 90% para os BAS 1 e 3, e 85% para o BAS 2, sendo independente do TDH aplicado. A remoção de SS foi maior no BAS contendo anéis Pall, provavelmente devido ao maior índice de vazios desse material.The post-treatment of effluents from anaerobic reactors is normally a mandatory step to meet the emission standards. The results presented here show the feasibility of using a new configuration of biological aerated filter (BAF in the post-treatment of UASB reactors. The multi-stage BAF presents an anaerobic chamber (V=12.6L, followed by an aerobic chamber (V=30L and an anoxic chamber (V=26.4L, all in series (total V=70L. This study examined the removal of suspended solids (SS, COD and BOD5. Three multi-stage BAF filled with three different packing materials were used: lids and bottlenecks of PET bottles (165m²/m³, gravel n. 4 (50m²/m³ and Pall rings 1.5'' (135m²/m³. The reactors were operated with the values of hydraulic detention time (HDT of 4.1, 8.2 and 12.3 hours, and

  12. Implementing Environmental Management Accounting: Status and Challenges

    DEFF Research Database (Denmark)

    : Visualizing the Policy Challenges of Environmental Management Accounting; Dick Osborn. Section 2 Exploring EMA implementation issues. 6. Environmental Performance and the Quality of Corporate Environmental Reports: The Role of Environmental Management Accounting; Marcus Wagner. 7. Environmental Risk...... in Argentina; Graciela Maria Scavone.14. Environmental Management Accounting in the Framework of EMAS II in the Czech Republic; Jaroslava Hyrslova and Miroslav Hájek. 15. The Role of Government in Promoting and Implementing Environmental Management Accounting: The Case of Bangladesh; Abdul Hannan Mia. 16......Table of contents Preface. 1. Environmental Management Accounting: Innovation or Managerial Fad?; Pall Rikhardsson, Martin Bennett, Jan Jaap Bouma and Stefan Schaltegger. Section 1 Progress. 2. Challenges for Environmental Management Accounting; Roger L. Burritt 3. Current Trends in Environmental...

  13. Filters in autologous blood retransfusion systems affect the amount of blood cells retransfused in total knee arthroplasty: a pilot study.

    Science.gov (United States)

    Moonen, Adrianus F C M; Pilot, Peter; Meijers, Wil G H; Waelen, Richard A J; Leers, Mathie P G; Grimm, Bernd; Heyligers, Ide C

    2008-04-01

    A pilot study was undertaken to evaluate whether filters integrated in postoperative retransfusion systems affect the amount of blood cells retransfused after total knee arthroplasty. Twenty-two consecutive patients received either the Donor retransfusion system (n=12 patients) or the Bellovac ABT retransfusion system (n=10). Both systems differ with respect to the type of filter, a Pall Lipiguard filter and a Sangopur filter, respectively. At the beginning of the retransfusion, blood samples were taken before and after the filter. The filter of the Donor system significantly decreased the amount of leukocytes and erythrocytes, whereas the filter of the Bellovac system did not. As a result the haemoglobin level of retransfused blood with the Donor system was significantly lower than with the Bellovac system. It can be concluded that the type of filter integrated in two postoperative autologous blood retransfusion systems significantly affected the amount of blood cells retransfused in patients undergoing total knee arthroplasty.

  14. Leukocyte removal filtration of platelet concentrates

    International Nuclear Information System (INIS)

    Wadenvik, H.; Kutti, J.; Lindholm, A.

    1991-01-01

    111 In labelled platelets and gamma camera scintigraphy were used for the study of the platelet loss during leukocyte removal filtration of stored platelets. Two different filters were examined, Imugard IG500 and Pall PL100, and platelet pools containing varying number of platelet concentrates were filtered. It was found that a sizeable amount of the platelets was trapped within the filter. Some of the trapped platelets could be recovered by rinsing the filters with normal saline. The most appropriate rinsing volume to recover lost platelets seemed to match with the ''dead space'' volume within the filter. It is concluded that radiolabelled platelets and gamma camera scintigraphy appears to be an excellent method to investigate the dynamic events of platelet loss during leukocyte removal filtration. This technique should be well applicable for the study of technological advances in filter construction. (author)

  15. "edo jal̀qkina üts̀varòkaetus ma vaelda ..." : [luuletused] / Andreas Kalkun

    Index Scriptorium Estoniae

    Kalkun, Andreas, 1977-

    2002-01-01

    Sisu: "edo jal̀qkina üts̀varòkaetus ma vaelda ..." ; "tsirguq ku kiviq no satassõ taivast aràlaq ..." ; "vahtsõq silmäq pitsitä pääluu sisse ..." ; "tõppõ tõmmat haigõst ma haarõt jal̀ki ..." ; "arsatas njago sisse aigopiteh ..." ; "rühkeq yks jumalat pallõlda jaloh ..." ; "mu süä om no süüdläne täǹtäseq kuvvõ ..." ; "halvaq haavaq häitsese veiga silmih. Eluloolisi andmeid autori kohta lk. 379

  16. TESTING OF A FULL-SCALE ROTARY MICROFILTER FOR THE ENHANCED PROCESS FOR RADIONUCLIDES REMOVAL

    Energy Technology Data Exchange (ETDEWEB)

    Herman, D; David Stefanko, D; Michael Poirier, M; Samuel Fink, S

    2009-01-01

    Savannah River National Laboratory (SRNL) researchers are investigating and developing a rotary microfilter for solid-liquid separation applications in the Department of Energy (DOE) complex. One application involves use in the Enhanced Processes for Radionuclide Removal (EPRR) at the Savannah River Site (SRS). To assess this application, the authors performed rotary filter testing with a full-scale, 25-disk unit manufactured by SpinTek Filtration with 0.5 micron filter media manufactured by Pall Corporation. The filter includes proprietary enhancements by SRNL. The most recent enhancement is replacement of the filter's main shaft seal with a John Crane Type 28LD gas-cooled seal. The feed material was SRS Tank 8F simulated sludge blended with monosodium titanate (MST). Testing examined total insoluble solids concentrations of 0.06 wt % (126 hours of testing) and 5 wt % (82 hours of testing). The following are conclusions from this testing.

  17. ESENSIALITAS METODE STAD (STUDENT TEAMS ACHIEVEMENT DIVISION UNTUK PENDALAMAN MATERI BAHASA INDONESIA DI SEKOLAH

    Directory of Open Access Journals (Sweden)

    Siti Nurhidayatul hasanah

    2015-06-01

    Full Text Available In the presence a portion student that declares for that Indonesian study really palls is fairly, since they have perceived can and forwarding material which unattractive so at second hand student become arrest deep frail that material. As teacher of Indonesian was necessarily feels happening learning problem all this time. So teacher necessarily tries do changes in Indonesian learning at within class. One of change which is done by use of method role play and STAD'S method (Student Teams Achievement division in standart interest converses and reading. In learning Tells hobby, can be done by use of method role play so makes student more active. Method role play understanding language as skill of straightforward speaking with bases student life in masayarakat. Method role play well-matched being applied while teacher does speaking learning with aided with role card.

  18. Filtration effects of zebra mussels on pathogens and total bacterial burden in the Odra Lagoon (South Baltic).

    Science.gov (United States)

    Daeschlein, G; Fenske, C; Scholz, S; Dahlke, S; Jünger, M; Kramer, A

    2015-01-01

    As a result of their mode of filter feeding, zebra mussels (Dreissena polymorpha Pall.) have been observed to purify natural water bodies and in vitro. Therefore, the possibility of using zebra mussels for water purification was investigated in a slightly brackish water body of a large lagoon. In this study, water samples were taken above, near and at distance from zebra mussel beds (MB) in the Odra Lagoon in North East Germany. Near typical bacterial species like Aeromonas spp. pathogenic bacteria with potential relation to hospital wastewater pollution (Burkholderia cepacia, Staphylococcus aureus, Weeksella spp.) were detected. There were no correlations found between either total bacteria or pathogens and distance to MB and no antimicrobial effect of the mussels could be deduced. For bioremediation in larger water bodies like lagoons, natural zebra MB do not seem to play a major antimicrobial role and the effect of artificial mussel grids especially against hospital pathogens should be investigated.

  19. The Effects of Zebra Mussels (Dreissena polymorpha) on the Foraging Success of Eurasian Perch (Perca fluviatilis) and Ruffe (Gymnocephalus cernuus)

    Science.gov (United States)

    Dieterich, Axel; Mörtl, Martin; Eckmann, Reiner

    2004-07-01

    Complex habitat structures can influence the foraging success of fish. Competition for food between fish species can therefore depend on the competitors' abilities to cope with structural complexity. In laboratory experiments, we comparatively assessed effects of zebra mussels (Dreissena polymorpha Pall.) on the foraging success of Eurasian perch (Perca fluviatilis L.) and ruffe (Gymnocephalus cernuus (L.)). In single-species and mixed-species experiments, the fish were fed caddisfly larvae (Tinodes waeneri (L.)) over complex (mussel-covered stones) and less-complex (bare stones) substrates. With intraspecific competition, food consumption by perch and ruffe decreased significantly when the complex substrate was used. With interspecific competition, food consumption by perch and ruffe did not change with substrate complexity, but perch clearly out-competed ruffe on both substrates. Zebra mussel beds provide a refuge for macrozoobenthos against predation by ruffe and probably also by perch. (

  20. Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte.

    Science.gov (United States)

    Zhao, Lei; Ye, Juan; Wu, Guo-Tai; Peng, Xue-Jing; Xia, Peng-Fei; Ren, Yuan

    2015-08-22

    In traditional Chinese medicine, Gentiana macrophylla Pall have been prescribed for the treatment of pain and inflammatory conditions. In addition, it is a common Tibetan medicinal herb used for the treatment of tonsillitis, urticaria, and rheumatoid arthritis (RA), while the flowers of G. macrophylla Pall have been traditionally treated as an anti-inflammatory agent to clear heat in Mongolian medicine. The secoiridoid glycosides and their derivatives are the primary active components of G. macrophylla and have been demonstrated to be effective as anti-inflammatory agents. Solvent extraction and D101 macroporous resin columns were employed to concentratethe gentiopicroside. Gentiopicroside cytotoxicity was assessed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; the toxicity of gentiopicroside in chondrocytes was reconfirmed using Hoechst staining. Western blotting, reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry were utilized to explore the protective effects and mechanisms of gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte. The MTT assay demonstrated that 50, 500, and 1,500 μg/mL of gentiopicroside exhibited no significant toxicity to chondrocytes (P>0.05) after 24h. Using immunohistochemistry, ELISA, RT-PCR, Western blot method to explore the protective effect and mechanism of gentiopicroside on chondrocytes induced by IL-1β. The results showed some pathways of IL-1β signal transduction were inhibited by gentiopicroside in rat chondrocytes: p38, ERK and JNK. Meanwhile, gentiopicroside showed inhibition in the IL-1β-induced release of MMPs while increasing Collagen type II expression. The current study demonstrated that gentiopicroside exhibited a potent protective effect on IL-1β induced inflammation response in rat articular chondrocyte. Thus, gentiopicroside could be a potential therapeutic strategy for treatment of OA. Copyright © 2015

  1. The pollen complex from postglacial sediments of the Laptev Sea as a bioindicator

    Science.gov (United States)

    Naidina, O. D.

    2014-05-01

    The first results of comparison of palynological analysis (pollen of terrestrial plants), SEM analysis of pollen morphology, and radiocarbon age dating (AMS14C) of sediments of the eastern shelf of the Laptev Sea show that the diverse taxonomic composition of pollen spectra provides an integrated idea of the vegetation and climate of the region over 11.2 calendar kiloyears. It is found that phases of the tree and shrub vegetation development (maxima of pollen of Betula sect. Nanae and Pinus s/g Haploxylon) correspond to the warm epochs in the Holocene. It is obvious that birch phytocoenoses first settled in the southern tundra subzone with increasing temperature, and then coniferous communities of forest tundra. An occurrence of pollen of shrubby birches (Nanae) suggests compliance of permafrost landscapes with cold climate conditions, i.e., with an annual average temperature of -2°C and amount of precipitation of less than 500 mm. Owing to a progressive increase in summer temperatures, dwarf cedar and pine communities advanced toward the seashore. The SEM analysis results show that a significant proportion of regional coniferous pollen belongs to representatives of Pinus pumila (Pall.) and P. sylvestris L. In addition, the SEM study of the exine of Pinus sylvestris L. and P. pumila (Pall.) Regel pollen grains confirmed polymorphism in coniferous pollen. According to the inverse relationship between climate and vegetation, frequent climate fluctuations that are typical of progressive and differential postglacial transgression were revealed. An increase in arboreal pollen transfer onto the shelf later than 9.1 cal. ka coincides with the time of forest boundary migration to the north due to the warming of the Earth's climate. At that time, the tundra vegetation was replaced by forest-tundra vegetation, the maximum stage of sea transgression began, and there appeared a trend of increasing temperature and moisture.

  2. Epithermal Neutron Activation Analysis of the Asian Herbal Plants

    Science.gov (United States)

    Baljinnyam, N.; Jugder, B.; Norov, N.; Frontasyeva, M. V.; Ostrovnaya, T. M.; Pavlov, S. S.

    2011-06-01

    Asian medicinal herbs Chrysanthemum (Spiraea aquilegifolia Pall.) and Red Sandalwood (Pterocarpus Santalinus) are widely used in folk and Ayurvedic medicine for healing and preventing some diseases. The modern medical science has proved that the Chrysanthemum (Spiraea aquilegifolia Pall.) possesses the following functions: reducing blood press, dispelling cancer cell, coronary artery's expanding and bacteriostating and Red Sandalwood (Pterocarpus Santalinus) is recommended against headache, toothache, skin diseases, vomiting and sometimes it is taken for treatment of diabetes. Species of Chrysanthemums were collected in the north-eastern and central Mongolia, and the Red Sandalwood powder was imported from India. Samples of Chrysanthemums (branches, flowers and leaves) (0.5 g) and red sandalwood powder (0.5 g) were subjected to the multi-element instrumental neutron activation analysis using epithermal neutrons (ENAA) at the IBR-2 reactor, Frank Laboratory of Neutron Physics (FLNP) JINR, Dubna. A total of 41 elements (Na, Mg, Al, Cl, K, Ca, Sc, V, Cr, Mn, Fe, Co, Ni, Zn, As, Se, Br, Rb, Sr, Zr, Mo, Cd, Cs, Ba, La, Hf, Ta, W, Sb, Au, Hg, Ce, Nd, Sm, Eu, Tb, Dy, Yb, Th, U, Lu) were determined. For the first time such a large group of elements was determined in the herbal plants used in Mongolia. The quality control of the analytical results was provided by using certified reference material Bowen Cabbage. The results obtained are compared to the "Reference plant» data (B. Markert, 1992) and interpreted in terms of excess of such elements as Se, Cr, Ca, Fe, Ni, Mo, and rare earth elements.

  3. Epithermal Neutron Activation Analysis of the Asian Herbal Plants

    International Nuclear Information System (INIS)

    Baljinnyam, N.; Frontasyeva, M. V.; Ostrovnaya, T. M.; Pavlov, S. S.; Jugder, B.; Norov, N.

    2011-01-01

    Asian medicinal herbs Chrysanthemum (Spiraea aquilegifolia Pall.) and Red Sandalwood (Pterocarpus Santalinus) are widely used in folk and Ayurvedic medicine for healing and preventing some diseases. The modern medical science has proved that the Chrysanthemum (Spiraea aquilegifolia Pall.) possesses the following functions: reducing blood press, dispelling cancer cell, coronary artery's expanding and bacteriostating and Red Sandalwood (Pterocarpus Santalinus) is recommended against headache, toothache, skin diseases, vomiting and sometimes it is taken for treatment of diabetes. Species of Chrysanthemums were collected in the north-eastern and central Mongolia, and the Red Sandalwood powder was imported from India. Samples of Chrysanthemums (branches, flowers and leaves)(0.5 g) and red sandalwood powder (0.5 g) were subjected to the multi-element instrumental neutron activation analysis using epithermal neutrons (ENAA) at the IBR-2 reactor, Frank Laboratory of Neutron Physics (FLNP) JINR, Dubna. A total of 41 elements (Na, Mg, Al, Cl, K, Ca, Sc, V, Cr, Mn, Fe, Co, Ni, Zn, As, Se, Br, Rb, Sr, Zr, Mo, Cd, Cs, Ba, La, Hf, Ta, W, Sb, Au, Hg, Ce, Nd, Sm, Eu, Tb, Dy, Yb, Th, U, Lu) were determined. For the first time such a large group of elements was determined in the herbal plants used in Mongolia. The quality control of the analytical results was provided by using certified reference material Bowen Cabbage. The results obtained are compared to the ''Reference plant? data (B. Markert, 1992) and interpreted in terms of excess of such elements as Se, Cr, Ca, Fe, Ni, Mo, and rare earth elements.

  4. [Epidemiology of Spinal Cord Injury in Iceland from 1975 to 2014].

    Science.gov (United States)

    Kristinsdottir, Eyrún Arna; Knutsdottir, Sigrun; Sigvaldason, Kristinn; Jonsson, Halldor; Ingvarsson, Pall E

    2016-11-01

    Traumatic spinal cord injury (TSCI) is serious and often has long-term consequences. Since no cure has been found the emphasis has been on preventive measures. The incidence of TSCI varies between countries and the epidemiology has been changing. The aim of this study was to gather epidemiological data on patients with TSCI in Iceland and search for risk factors. Hospital records of everyone diagnosed with TSCI in 1975-2014 admitted to Landspitali University Hospital were reviewed and information gathered on incidence, age, gender and causes of injury. The American Spinal Injury Association Impairment Scale (AIS) was used to assess the extent of TSCI. A total of 233 patients were diagnosed with TSCI during the study period or 26 per million annually on average. Males were 73% and the mean age was 39 years. Traffic accidents were the most common cause of TSCI. The majority were car rollovers in rural areas. Around 50% did not use a seatbelt. The second most common cause of TSCI were falls. The most common sport/leisure accidents were those related to horseback-riding and winter sports. A third of patients had a complete SCI. At discharge 9% had gained full recovery. Safe roads and good traffic culture are essential factors in the prevention of serious traffic accidents. Strict safety regulations in the work place and an investigation of causes of falls amongst the elderly could decrease SCIs due to falls. Further preventive measures and protective equipment could possibly be of use in sport- or leisure-related activities. Key words: Traumatic spinal cord injury, incidence, age, gender, causes, extent. Correspondence: Pall E. Ingvarsson, palling@landspitali.is.

  5. Effect of Compression on the Molecular Arrangement of Itraconazole-Soluplus Solid Dispersions: Induction of Liquid Crystals or Exacerbation of Phase Separation?

    Science.gov (United States)

    Singh, Abhishek; Bharati, Avanish; Frederiks, Pauline; Verkinderen, Olivier; Goderis, Bart; Cardinaels, Ruth; Moldenaers, Paula; Van Humbeeck, Jan; Van den Mooter, Guy

    2016-06-06

    Predensification and compression are unit operations imperative to the manufacture of tablets and capsules. Such stress-inducing steps can cause destabilization of solid dispersions which can alter their molecular arrangement and ultimately affect dissolution rate and bioavailability. In this study, itraconazole-Soluplus solid dispersions with 50% (w/w) drug loading prepared by hot-melt extrusion (HME) were investigated. Compression was performed at both pharmaceutically relevant and extreme compression pressures and dwell times. The starting materials, powder, and compressed solid dispersions were analyzed using modulated differential scanning calorimetry (MDSC), X-ray diffraction (XRD), small- and wide-angle X-ray scattering (SWAXS), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and broadband dielectric spectroscopy (BDS). MDSC analysis revealed that compression promotes phase separation of solid dispersions as indicated by an increase in glass transition width, occurrence of a peak in the nonreversing heat flow signal, and an increase in the net heat of fusion indicating crystallinity in the systems. SWAXS analysis ruled out the presence of mesophases. BDS measurements elucidated an increase in the Soluplus-rich regions of the solid dispersion upon compression. FTIR indicated changes in the spatiotemporal architecture of the solid dispersions mediated via disruption in hydrogen bonding and ultimately altered dynamics. These changes can have significant consequences on the final stability and performance of the solid dispersions.

  6. A Portable Farmland Information Collection System with Multiple Sensors

    Directory of Open Access Journals (Sweden)

    Jianfeng Zhang

    2016-10-01

    Full Text Available Precision agriculture is the trend of modern agriculture, and it is also one of the important ways to realize the sustainable development of agriculture. In order to meet the production requirements of precision agriculture—efficient use of agricultural resources, and improving the crop yields and quality—some necessary field information in crop growth environment needs to be collected and monitored. In this paper, a farmland information collection system is developed, which includes a portable farmland information collection device based on STM32 (a 32-bit comprehensive range of microcontrollers based on ARM Crotex-M3, a remote server and a mobile phone APP. The device realizes the function of portable and mobile collecting of multiple parameters farmland information, such as chlorophyll content of crop leaves, air temperature, air humidity, and light intensity. UM220-III (Unicore Communication Inc., Beijing, China is used to realize the positioning based on BDS/GPS (BeiDou Navigation Satellite System, BDS/Global Positioning System, GPS dual-mode navigation and positioning system, and the CDMA (Code Division Multiple Access, CDMA wireless communication module is adopted to realize the real-time remote transmission. The portable multi-function farmland information collection system is real-time, accurate, and easy to use to collect farmland information and multiple information parameters of crops.

  7. Semi-automatic bubble counting system for superheated droplet detectors

    International Nuclear Information System (INIS)

    Reina, Luiz C.; Bellido, Luis F.; Ramos, Paulo R.; Silva, Ademir X. da; Facure, Alessandro; Dantas, Jose E.R.

    2009-01-01

    Neutron dose rate measurements are normally performed by means of PADC, CR-39 and TLD detectors. Although, none of these devices can give instant reading of the neutron dose, recently new kind of detectors are being developed, based on the formation of tiny drops in a superheated liquid suspended in a polymer or gel solution, called superheated droplet detector (SDD) or also as bubble detectors (BD), with no response for gamma radiation. This work describes the experimental setup and the developed procedures for acquiring and processing digital images obtained with bubble detector spectrometer (BDS), developed by Bubble Technology Industries, for personal neutron dosimeter and/or neutron energy fluence measurements in nuclear facilities. The results of the neutron measurements obtained during the F-18 production, at the RDS-111 cyclotron, are presented. These neutron measurements were the first ones with this type of BDS detectors in a particle accelerator facility in Brazil and it was very important to estimate neutron dose rate received by occupationally exposed individuals. (author)

  8. Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: Black cohosh from the field to the clinic

    Science.gov (United States)

    Farnsworth, Norman R; Mahady, Gail B.

    2009-01-01

    In 1999, the Department of Medicinal Chemistry and Pharmacognosy at the College of Pharmacy, University of Illinois (UIC) at Chicago was funded to establish a Botanical Dietary Supplements Research Center from the National Institutes of Health (NIH). The emphasis of the UIC/NIH Center for Botanical Dietary Supplements Research (CBDSR) is botanical dietary supplements (BDS) for women's health. Center’s research has focused on BDS that may improve women's health and quality of life, specifically in the areas of menopause, premenstrual syndrome, and persistent urinary tract infections. Center investigators have overcome many challenges associated with botanical dietary supplements research, including acquiring and identifying plant species for investigation, isolating and identifying active constituents, elucidating the mechanisms of action of these botanicals, and conducting phase I and phase II clinical studies. Black cohosh [Actaea racemosa L. (Ranunculaceae)] has been used as a model to illustrate the steps involved in taking a botanical dietary supplement from the field, all the way to clinical trials. Bioassays are described that were necessary to elucidate the pertinent biological studies of plant extracts and their mechanisms of action. The Center has used an innovative multidisciplinary approach to this type of research, and thus has been very successful in fulfilling its specific aims. PMID:20161501

  9. Toxicity evaluation of 2-hydroxybiphenyl and other compounds involved in studies of fossil fuels biodesulphurisation.

    Science.gov (United States)

    Alves, L; Paixão, S M

    2011-10-01

    The acute toxicity of some compounds used in fossil fuels biodesulphurisation studies, on the respiration activity, was evaluated by Gordonia alkanivorans and Rhodococcus erythropolis. Moreover, the effect of 2-hydroxybiphenyl on cell growth of both strains was also determined, using batch (chronic bioassays) and continuous cultures. The IC₅₀ values obtained showed the toxicity of all the compounds tested to both strains, specially the high toxicity of 2-HBP. These results were confirmed by the chronic toxicity data. The toxicity data sets highlight for a higher sensitivity to the toxicant by the strain presenting a lower growth rate, due to a lower cells number in contact with the toxicant. Thus, microorganisms exhibiting faster generation times could be more resistant to 2-HBP accumulation during a BDS process. The physiological response of both strains to 2-HBP pulse in a steady-state continuous culture shows their potential to be used in a future fossil fuel BDS process. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Determination of petrophysical properties of sedimentary rocks by optical methods

    Science.gov (United States)

    Korte, D.; Kaukler, D.; Fanetti, M.; Cabrera, H.; Daubront, E.; Franko, M.

    2017-04-01

    Petrophysical properties of rocks (thermal diffusivity and conductivity, porosity and density) as well as the correlation between them are of great importance for many geoscientific applications. The porosity of the reservoir rocks and their permeability are the most fundamental physical properties with respect to the storage and transmission of fluids, mainly oil characterization. Accurate knowledge of these parameters for any hydrocarbon reservoir is required for efficient development, management, and prediction of future performance of the oilfield. Thus, the porosity and permeability, as well as the chemical composition must be quantified as precisely as possible. This should be done along with the thermal properties, density, conductivity, diffusivity and effusivity that are intimately related with them. For this reason, photothermal Beam Deflection Spectrometry (BDS) technique for determination of materials' thermal properties together with other methods such as Energy Dispersive X-ray Scanning Electron Microscopy (SEM-EDX) for determining the chemical composition and sample structure, as well as optical microscopy to determine the particles size, were applied for characterization of sedimentary rocks. The rocks were obtained from the Andes south flank in the Venezuela's western basin. The validation of BDS applicability for determination of petrophysical properties of three sedimentary rocks of different texture and composition (all from Late Cretaceous associated with the Luna, Capacho and Colón-Mito Juan geological formations) was performed. The rocks' thermal properties were correlated to the microstructures and chemical composition of the examined samples.

  11. Interest in broadband dielectric spectroscopy to study the electronic transport in materials for lithium batteries

    Energy Technology Data Exchange (ETDEWEB)

    Badot, Jean-Claude, E-mail: jc.badot@chimie-paristech.fr [Institut de Recherche de Chimie Paris, UMR CNRS 8247, Réseau sur le Stockage Electrochimique de l' Energie (RS2E), Chimie Paris Tech, PSL*, 11 rue P. et M. Curie, 75231 Cedex 05 Paris (France); Lestriez, Bernard [Institut des Matériaux Jean Rouxel, UMR CNRS 6502, Université de Nantes, 2 rue de la Houssinière, BP32229, 44322 Nantes (France); Dubrunfaut, Olivier [GeePs | Group of electrical engineering – Paris, UMR CNRS 8507, CentraleSupélec, Univ. Paris-Sud, Université Paris-Saclay, Sorbonne Universités, UPMC Univ Paris 06, 3 & 11 rue Joliot-Curie, Plateau de Moulon, 91192 Gif-sur-Yvette CEDEX, Paris (France)

    2016-11-15

    Highlights: • Broadband dielectric spectroscopy measures the multiscale electronic conductivity from macroscopic to interatomic sizes. • There is an influence of the surface states on the electronic transfer of powdered materials (e.g. thin insulating layer of Li{sub 2}CO{sub 3} on LiNiO{sub 2} and carbon coating on LiFePO{sub 4}). • Electrical relaxations resulting from the interfacial polarizations at the different scales of the carbon black network are evidenced. - Abstract: Broadband dielectric spectroscopy (BDS) is used to measure complex permittivity and conductivity of conducting materials for lithium batteries at frequencies from a few Hz to several GHz with network and impedance analysers. Under the influence of an electric field, there will be charge density fluctuations in the conductor mainly due to electronic transfer. These fluctuations result in dielectric relaxations for frequencies below 100 GHz. The materials are compacted powders in which each element (particles, agglomerates of particles) can have different sizes and morphologies. In the present review, studies are reported on the influence of surface states in LiNiO{sub 2} (ageing and degradation in air) and LiFePO{sub 4} (carbon coating thin layer), and on a composite electrode based on the lithium trivanadate (Li{sub 1.1}V{sub 3}O{sub 8}) active material. The results have shown that the BDS technique is very sensitive to the different scales of materials architectures involved in electronic transport, from interatomic distances to macroscopic sizes.

  12. JVLA Observations of Young Brown Dwarfs

    Energy Technology Data Exchange (ETDEWEB)

    Rodríguez, Luis F.; Zapata, Luis A.; Palau, Aina, E-mail: l.rodriguez@crya.unam.mx, E-mail: l.zapata@crya.unam.mx, E-mail: a.palau@crya.unam.mx [Instituto de Radioastronomía y Astrofísica, UNAM, Apdo. Postal 3-72 (Xangari), 58089 Morelia, Michoacán, México (Mexico)

    2017-05-01

    We present sensitive 3.0 cm JVLA radio continuum observations of six regions of low-mass star formation that include twelve young brown dwarfs (BDs) and four young BD candidates. We detect a total of 49 compact radio sources in the fields observed, of which 24 have no reported counterparts and are considered new detections. Twelve of the radio sources show variability in timescales of weeks to months, suggesting gyrosynchrotron emission produced in active magnetospheres. Only one of the target BDs, FU Tau A, was detected. However, we detected radio emission associated with two of the BD candidates, WL 20S and CHLT 2. The radio flux densities of the sources associated with these BD candidates are more than an order of magnitude larger than expected for a BD and suggest a revision of their classification. In contrast, FU Tau A falls on the well-known correlation between radio luminosity and bolometric luminosity, suggesting that the emission comes from a thermal jet and that this BD seems to be forming as a scaled-down version of low-mass stars.

  13. THE FIRST ULTRA-COOL BROWN DWARF DISCOVERED BY THE WIDE-FIELD INFRARED SURVEY EXPLORER

    International Nuclear Information System (INIS)

    Mainzer, A.; Cushing, Michael C.; Eisenhardt, P.; Skrutskie, M.; Beaton, R.; Gelino, C. R.; Kirkpatrick, J. Davy; Jarrett, T.; Masci, F.; Marsh, K.; Padgett, D.; Marley, Mark S.; Saumon, D.; Wright, E.; McLean, I.; Dietrich, M.; Garnavich, P.; Rueff, K.; Kuhn, O.; Leisawitz, D.

    2011-01-01

    We report the discovery of the first new ultra-cool brown dwarf (BDs) found with the Wide-field Infrared Survey Explorer (WISE). The object's preliminary designation is WISEPC J045853.90+643451.9. Follow-up spectroscopy with the LUCIFER instrument on the Large Binocular Telescope indicates that it is a very late-type T dwarf with a spectral type approximately equal to T9. Fits to an IRTF/SpeX 0.8-2.5 μm spectrum to the model atmospheres of Marley and Saumon indicate an effective temperature of approximately 600 K as well as the presence of vertical mixing in its atmosphere. The new BD is easily detected by WISE, with a signal-to-noise ratio of ∼36 at 4.6 μm. Current estimates place it at a distance of 6-10 pc. This object represents the first in what will likely be hundreds of nearby BDs found by WISE that will be suitable for follow-up observations, including those with the James Webb Space Telescope. One of the two primary scientific goals of the WISE mission is to find the coolest, closest stars to our Sun; the discovery of this new BD proves that WISE is capable of fulfilling this objective.

  14. The relationship between microvascular complications and depression in patients with type 2 diabetes mellitus who use insulin

    Directory of Open Access Journals (Sweden)

    Mehmet Ali Eren

    2013-03-01

    Full Text Available Objective: This study aimed to assess the relationshipbetween Type 2 Diabetes Mellitus (DM and its complicationswith the severity of depression.Methods: Eighty diabetics under the age of 65 usinginsulin were enrolled and clinical and biochemical datawere recorded. The severity of neuropathy was determinedby the “United Kingdom neuropathy screeningscore” (UKNS whereas the severity of depression wasdetermined by the “Beck depression scale” (BDS. Nephropathyand retinopathy were assessed by the microalbumin-creatinine ratio in spot urine samples and by detailedexamination of the retina with an ophthalmoscope,respectively.Results: There were more patients who has high neuropathyseverity in the group with the highest Beck depressionscale score (p<0.001. In the correlation analyses,positive correlation was found between the severity ofdepression determined by the BDS and UKNS (r=0.231,p=0.039. No relationship was found between nephropathy,retinopathy and severity of depression.Conclusion: There was significant relationship betweenthe severity of neuropathy and that of depression. Hence,cases with a diagnosis of Type 2 DM require screening interms of neuropathy and the presence of depression. Appropriateapproach towards such conditions associatedwith each other may be crucial in the context of increasingthe quality of life. J Clin Exp Invest 2013; 4 (1: 34-39Key words: Type 2 Diabetes Mellitus; neuropathy, nephropathy; retinopathy; depression

  15. Eating Attitudes and Related Factors in Turkish Nursing Students.

    Science.gov (United States)

    Celik, Sevim; Ugur, Bayram Ali; Aykurt, Fethi Ahmet; Bektas, Muammer

    2015-06-01

    Changing eating behaviors might trigger obesity, deficiency, anorexia nervosa, bulimia nervosa, and reactive eating disorders. This study aimed to determine eating attitudes of nursing students in the western Black-Sea region of Turkey as well as to examine the effects of demographic features, self-esteem, body image, income level, and family structure on their eating attitudes. This cross-sectional study was conducted on 310 nursing students between January and February 2014. Data were collected using the personal information form, Eating Attitudes Test (EAT), Rosenberg Self-Esteem Scale (RSES), Beck Depression Scale (BDS), Body-Cathexis Scale (BCS), and Body Mass Index (BMI). Data were evaluated by descriptive statistics, independent samples t-test, one-way ANOVA, Kruskal-Wallis test, and Pearson correlation analysis. About 30.0% of Turkish nursing students had negative eating attitudes. There was a significant positive correlation between the BDS and EAT scores (P EAT scores of nursing students (P eating attitudes. Psychological status, self-esteem, economic level, and place of residence of nursing students may be the potential factors for eating disorders.

  16. Electrodeposition of thin Pd-Ag films

    International Nuclear Information System (INIS)

    Hasler, P.; Allmendinger, T.

    1993-01-01

    Thin Pd-Ag layers were electroplated preferably on brass and on nickel substrates using a two-compartment cell separated by an anion exchange membrane. The weakly alkaline electrolyte contained glycine-glycinate as the major complexing agents. The plating experiments were usually carried out without stirring, at different potentials and temperatures and in the absence or in the presence of sodium benzaldehyde-2,4-disulphonate (BDS). The samples were characterized by scanning electron microscopy and light microscopy. Their compositions were determined analytically by the inductively coupled plasma technique. In addition, the film porosity was tested. Electrodeposition in almost limiting current conditions for both components and without simultaneous hydrogen evolution led to deposits with compositions being in good agreement with the molar metal ratio in the electrolyte (77:23). The best results were achieved between 0 and -50 mV with respect to a reversible hydrogen electrode at 0 C in the presence of BDS. These deposits were bright, had good adherence and exhibited no pores at a film thickness of 1.2 μm. At too negative potentials, the deposits became black and powdery. (orig.)

  17. Many-body quantum dynamics in the decay of bent dark solitons of Bose-Einstein condensates

    Science.gov (United States)

    Katsimiga, G. C.; Mistakidis, S. I.; Koutentakis, G. M.; Kevrekidis, P. G.; Schmelcher, P.

    2017-12-01

    The beyond mean-field (MF) dynamics of a bent dark soliton (BDS) embedded in a two-dimensional repulsively interacting Bose-Einstein condensate is explored. We examine the case of a single BDS comparing the MF dynamics to a correlated approach, the multi-configuration time-dependent Hartree method for bosons. Dynamical snaking of this bent structure is observed, signaling the onset of fragmentation which becomes significant during the vortex nucleation. In contrast to the MF approximation ‘filling’ of the vortex core is observed, leading in turn to the formation of filled-core vortices, instead of the MF vortex-antivortex pairs. The resulting smearing effect in the density is a rather generic feature, occurring when solitonic structures are exposed to quantum fluctuations. Here, we show that this filling owes its existence to the dynamical building of an antidark structure developed in the next-to-leading order orbital. We further demonstrate that the aforementioned beyond MF dynamics can be experimentally detected using the variance of single shot measurements. Additionally, a variety of excitations including vortices, oblique dark solitons, and open ring dark soliton-like structures building upon higher-lying orbitals is observed. We demonstrate that signatures of the higher-lying orbital excitations emerge in the total density, and can be clearly captured by inspecting the one-body coherence. In the latter context, the localization of one-body correlations exposes the existence of the multi-orbital vortex-antidark structure.

  18. Disordered eating in three communities of China: a comparative study of female high school students in hong kong, Shenzhen, and rural hunan.

    Science.gov (United States)

    Lee, S; Lee, A M

    2000-04-01

    To examine disordered eating and its psychological correlates among female high school students in three Chinese communities that lay on a gradient of socioeconomic development in China. 796 Chinese students from Hong Kong, Shenzhen, and rural Hunan completed a demographic and weight data sheet, the Eating Attitudes Test (EAT-26), a Body Dissatisfaction Scale (BDS), the Beck Depression Inventory (BDI), and the Rosenberg Self-Esteem Scale (RSES). Compared to students in Hunan and to a lesser extent students in Shenzhen, students from Hong Kong were slimmer, but desired a lower body mass index (BMI), reported more body dissatisfaction, exhibited a more typical EAT-26 factor structure, scored higher on the "fat concern and dieting" factor, and constituted more EAT-26 high scorers. Multiple regression analyses indicated that BDS was the most significant predictor of fat concern at each site, but this effect was strongest in Hong Kong. Hunan students had significantly higher BDI scores but lower fat concern than Shenzhen and Hong Kong students. The consistent gradient of fat concern across the three communities gives credence to the view that societal modernization fosters disordered eating in women, possibly via the gendered social constraints that accompany it. It is also expressive of the marked socioeconomic heterogeneity within China nowadays. The predictable rising rate of eating disorders that follows global change will pose a growing public health challenge to Asian countries. Copyright 2000 by John Wiley & Sons, Inc.

  19. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.

    Science.gov (United States)

    Bouché, Léa; Christ, Clara D; Siegel, Stephan; Fernández-Montalván, Amaury E; Holton, Simon J; Fedorov, Oleg; Ter Laak, Antonius; Sugawara, Tatsuo; Stöckigt, Detlef; Tallant, Cynthia; Bennett, James; Monteiro, Octovia; Díaz-Sáez, Laura; Siejka, Paulina; Meier, Julia; Pütter, Vera; Weiske, Jörg; Müller, Susanne; Huber, Kilian V M; Hartung, Ingo V; Haendler, Bernard

    2017-05-11

    Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we describe a dual inhibitor of the bromodomain and PHD finger (BRPF) family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L. These proteins are found in large chromatin complexes and play important roles in transcription regulation. The substituted benzoisoquinolinedione series was identified by high-throughput screening, and subsequent structure-activity relationship optimization allowed generation of low nanomolar BRPF2 BD inhibitors with strong selectivity against BRPF1 and BRPF3 BDs. In addition, a strong inhibition of TAF1/TAF1L BD2 was measured for most derivatives. The best compound of the series was BAY-299, which is a very potent, dual inhibitor with an IC 50 of 67 nM for BRPF2 BD, 8 nM for TAF1 BD2, and 106 nM for TAF1L BD2. Importantly, no activity was measured for BRD4 BDs. Furthermore, cellular activity was evidenced using a BRPF2- or TAF1-histone H3.3 or H4 interaction assay.

  20. Study On Application Of Molecular Techniques (RAPD-PCR And RAMP-PCR) To Detect Mutation In Rice Breeding

    International Nuclear Information System (INIS)

    Hoang Thi My Linh; Phan, D. T. Son; Nguyen Thi Vang; Nguyen, T. T. Hien; Le XuanTham

    2007-01-01

    The project was carried out in 2007 with the purpose of consideration for using the two simple and inexpensive molecular techniques to estimate changes in DNA of rice mutant after gamma irradiation. Three rice cultivars: Basmati370, Tam Thom (TT1), IR64 and three gamma irradiated mutants BDS, TDS and VND 95-20 respectively, were used. Suitable DNA extraction procedure was obtained. PCR optimization was conducted on three important factors including: amount of MgCl 2 , DNA concentration and annealing temperature. 2.5 mM of MgCl 2 for RAPD-PCR and 3.75 mM for RAMP-PCR were found the best. 40 ng DNA provided a good amplification for RAMP-PCR; this figure was 50 ng for RAPD-PCR. Annealing temperatures were determined at 36 o C for RAPD primer and at 55±3 o C for Microsatellite primer. Final results showed that, both RAPD-PCR and RAMP-PCR could detect changes in DNA of rice mutants after gamma irradiation compared to their parents. Percentage of DNA changes determined by RAPD-PCR and RAMP-PCR on Basmati370 and its mutant BDS were 11.49% and 21.2% respectively; These on TT1 and TDS were 8.98% and 15.4%; and on IR64 and VND 95-20 were 3.45% and 4.95%. (author)

  1. Multi-modality analysis of glucose aqueous solution using photoacoustic and dielectric spectroscopy for non-invasive glucose monitoring

    Science.gov (United States)

    Tajima, Takuro; Tanaka, Yujiro; Nakamura, Masahito; Seyama, Michiko

    2017-03-01

    Quantitative analysis of glucose using conventional optical spectroscopy suffers from a lack of repeatability due to high optical scattering in skin tissue. Here we present a multi-modality analysis of glucose aqueous solution using photoacoustic spectroscopy (PAS) and broadband dielectric spectroscopy (BDS). These techniques involve the direct detection of the acoustic and electromagnetic waves propagating through or reflecting from tissue without their being scattered. They therefore have potential for better tolerance to the variation of scattering. For PAS, to differentiate signals induced by water absorption, we select another laser wavelength (1.38 μm) that exhibits the same absorbance for water at 1.61 μm. Furthermore, one of the two photoacoustic signals is used to normalize the variations of acoustic properties in differential signal. Measured results for glucose solutions (0-2 g/dL) showed that the differential signal has a sensitivity of 1.61%/g·dL-1 and a detection limit of 120 mg/dL. We also tested glucose detection with BDS (500 MHz to 50 GHz) by detecting glucose hydration bonding at around 10-20 GHz. Using a partial least square analysis and first derivation on broadband spectra, we obtained an RMS error 19 mg/dL and a detection limit of 59 mg/dL. Using both the low-scattering ultrasonic and microwave detection techniques, we successfully captured the glucose footprint in the physiological range.

  2. Psychiatry meets pharmacogenetics for the treatment of revolving door patients with psychiatric disorders.

    Science.gov (United States)

    Panza, Francesco; Lozupone, Madia; Stella, Eleonora; Lofano, Lucia; Gravina, Carolina; Urbano, Maria; Daniele, Antonio; Bellomo, Antonello; Logroscino, Giancarlo; Greco, Antonio; Seripa, Davide

    2016-12-01

    Therapeutic failures (TFs) and adverse drug reactions (ADRs), together with the recurring nature of the clinical course of psychiatric disorders, mainly bipolar disorders (BDs), strongly contributed to the prevalence and frequency of hospital readmissions observed in these patients. This is the revolving door (RD) condition, dramatically rising costs for the management of these patients in psychiatric settings. Areas covered: We searched in the medical literature until May 2016 to review the role of functional variants in the cytochrome P450 (CYP) 2D6 gene on observed ADRs and TFs in RD patients with BDs, conferring a different capacity to metabolize psychotropic drugs. Expert commentary: CYP2D6 functional polymorphisms might directly contributed to the prevalence and frequency of the RD condition, commonly observed in BD patients. Although several environmental and socio-demographic/diagnostic variables such as alcohol/drug abuse, and medication non-compliance accounted for a significant proportion of the ability to predict RD prevalence and frequency, the pharmacogenetics of CYP, particularly CYP2D6, may help to identify BD patients at risk for ADRs and TFs. These patients may be addressed towards alternative treatments, thus improving their quality of life, and reducing RD prevalence and frequency and the overall costs for their management.

  3. Micropropagation of onion (Allium cepa L.) from immature inflorescences.

    Science.gov (United States)

    Marinangeli, Pablo

    2013-01-01

    In vitro plant production by direct organogenesis from immature flower heads is an ideal approach for clonal propagation of onions (Allium cepa L.). This technique ensures genetic stability, high propagation rate, and maintains donor plant of explants with an advantage over other means of in vitro regeneration. Onion micropropagation is usually applied in breeding programs, maintenance, and multiplication of cytoplasmic-male sterile lines for hybrid production, germplasm conservation, and as a tool for the application of other biotechnologies. For in vitro culture, mature onion bulbs are induced to reproductive phase by vernalization and forced to inflorescence initiation. Immature umbels are dissected from bulbs or cut directly when they appear from the pseudostem among the leaves. Disinfected inflorescences are cultivated in BDS basal medium supplemented with 30 g/L sucrose, 0.1 mg/L naphthalene acetic acid, 1 mg/L N (6)-benzyladenine, and 8 g/L agar, pH 5.5, under 16 h photoperiod white fluorescent light (PPD: 50-70 μmol/m(2)s) for 35 days. The regenerated shoot clumps are divided and subculture under the same conditions. For bulbification phase, the individual shoots are cultured in BDS basal medium containing 90 g/L sucrose, without plant growth regulators, pH 5.5, under 16 h photoperiod. Microbulbs can be directly cultivated ex vitro without acclimation.

  4. A Portable Farmland Information Collection System with Multiple Sensors.

    Science.gov (United States)

    Zhang, Jianfeng; Hu, Jinyang; Huang, Lvwen; Zhang, Zhiyong; Ma, Yimian

    2016-10-22

    Precision agriculture is the trend of modern agriculture, and it is also one of the important ways to realize the sustainable development of agriculture. In order to meet the production requirements of precision agriculture-efficient use of agricultural resources, and improving the crop yields and quality-some necessary field information in crop growth environment needs to be collected and monitored. In this paper, a farmland information collection system is developed, which includes a portable farmland information collection device based on STM32 (a 32-bit comprehensive range of microcontrollers based on ARM Crotex-M3), a remote server and a mobile phone APP. The device realizes the function of portable and mobile collecting of multiple parameters farmland information, such as chlorophyll content of crop leaves, air temperature, air humidity, and light intensity. UM220-III (Unicore Communication Inc., Beijing, China) is used to realize the positioning based on BDS/GPS (BeiDou Navigation Satellite System, BDS/Global Positioning System, GPS) dual-mode navigation and positioning system, and the CDMA (Code Division Multiple Access, CDMA) wireless communication module is adopted to realize the real-time remote transmission. The portable multi-function farmland information collection system is real-time, accurate, and easy to use to collect farmland information and multiple information parameters of crops.

  5. Acaricidal activity of extracts from Petiveria alliacea (Phytolaccaceae) against the cattle tick, Rhipicephalus (Boophilus) microplus (Acari: ixodidae).

    Science.gov (United States)

    Rosado-Aguilar, J A; Aguilar-Caballero, A; Rodriguez-Vivas, R I; Borges-Argaez, R; Garcia-Vazquez, Z; Mendez-Gonzalez, M

    2010-03-25

    The acaricidal activity of crude extracts and fractions from stems and leaves of Petiveria alliacea (Phytolaccaceae) was carried out on larvae and adults of the cattle tick Rhipicephalus (Boophilus) microplus using the larval immersion test (LIT) and adult immersion test (AIT), respectively. Methanolic extracts of stems and leaves of P. alliacea showed 100% mortality on the LIT bioassay. On the other hand, methanolic extracts of leaves and stem on the AIT test showed 26% and 86% of mortality, respectively, egg laying inhibition of 40% and 91%, respectively and hatchability inhibition of 26% and 17%, respectively. Purification of the active stem methanolic extract showed that the activity was present in the n-hexane non-polar fraction. Bioassay-guided purification of the n-hexane fraction produced 10 semi-purified fractions; fraction B had the highest activity against tick larvae (100% mortality). Gas chromatography-mass spectrometry demonstrated that the chemical composition of the active fraction B samples were mainly composed of benzyltrisulfide (BTS) and benzyldisulfide (BDS). These metabolites might be responsible for the acaricidal activity of stem extract of P. alliacea. However, further experiments to evaluate the acaricidal activity of BTS and BDS on larvae and adults of R. (B.) microplus are needed. Our results showed that P. alliacea is a promising biocontrol candidate as acaricide against R. (B.) microplus resistant strains.

  6. Genotoxicity of lapachol evaluated by wing spot test of Drosophila melanogaster.

    Science.gov (United States)

    Costa, Wender Ferreira; de Oliveira, Alaide Braga; Nepomuceno, Júlio César

    2010-07-01

    This study investigated the genotoxicity of Lapachol (LAP) evaluated by wing spot test of Drosophila melanogaster in the descendants from standard (ST) and high bioactivation (HB) crosses. This assay detects the loss of heterozygosity of marker genes expressed phenotypically on the fly's wings. Drosophila has extensive genetic homology to mammals, which makes it a suitable model organism for genotoxic investigations. Three-day-old larvae from ST crosses (females flr(3)/TM3, Bd(s) x males mwh/mwh), with basal levels of the cytochrome P450 and larvae of high metabolic bioactivity capacity (HB cross) (females ORR; flr(3)/TM3, Bd(s) x males mwh/mwh), were used. The results showed that LAP is a promutagen, exhibiting genotoxic activity in larvae from the HB cross. In other words, an increase in the frequency of spots is exclusive of individuals with a high level of the cytochrome P450. The results also indicate that recombinogenicity is the main genotoxic event induced by LAP.

  7. Clouds and the Earth's Radiant Energy System (CERES) algorithm theoretical basis document. volume 2; Geolocation, calibration, and ERBE-like analyses (subsystems 1-3)

    Science.gov (United States)

    Wielicki, B. A. (Principal Investigator); Barkstrom, B. R. (Principal Investigator); Charlock, T. P.; Baum, B. A.; Green, R. N.; Minnis, P.; Smith, G. L.; Coakley, J. A.; Randall, D. R.; Lee, R. B., III

    1995-01-01

    The theoretical bases for the Release 1 algorithms that will be used to process satellite data for investigation of the Clouds and Earth's Radiant Energy System (CERES) are described. The architecture for software implementation of the methodologies is outlined. Volume 2 details the techniques used to geolocate and calibrate the CERES scanning radiometer measurements of shortwave and longwave radiance to invert the radiances to top-of-the-atmosphere (TOA) and surface fluxes following the Earth Radiation Budget Experiment (ERBE) approach, and to average the fluxes over various time and spatial scales to produce an ERBE-like product. Spacecraft ephemeris and sensor telemetry are used with calibration coefficients to produce a chronologically ordered data product called bidirectional scan (BDS) radiances. A spatially organized instrument Earth scan product is developed for the cloud-processing subsystem. The ERBE-like inversion subsystem converts BDS radiances to unfiltered instantaneous TOA and surface fluxes. The TOA fluxes are determined by using established ERBE techniques. Hourly TOA fluxes are computed from the instantaneous values by using ERBE methods. Hourly surface fluxes are estimated from TOA fluxes by using simple parameterizations based on recent research. The averaging process produces daily, monthly-hourly, and monthly means of TOA and surface fluxes at various scales. This product provides a continuation of the ERBE record.

  8. Instantaneous Real-Time Kinematic Decimeter-Level Positioning with BeiDou Triple-Frequency Signals over Medium Baselines

    Directory of Open Access Journals (Sweden)

    Xiyang He

    2015-12-01

    Full Text Available Many applications, such as marine navigation, land vehicles location, etc., require real time precise positioning under medium or long baseline conditions. In this contribution, we develop a model of real-time kinematic decimeter-level positioning with BeiDou Navigation Satellite System (BDS triple-frequency signals over medium distances. The ambiguities of two extra-wide-lane (EWL combinations are fixed first, and then a wide lane (WL combination is reformed based on the two EWL combinations for positioning. Theoretical analysis and empirical analysis is given of the ambiguity fixing rate and the positioning accuracy of the presented method. The results indicate that the ambiguity fixing rate can be up to more than 98% when using BDS medium baseline observations, which is much higher than that of dual-frequency Hatch-Melbourne-Wübbena (HMW method. As for positioning accuracy, decimeter level accuracy can be achieved with this method, which is comparable to that of carrier-smoothed code differential positioning method. Signal interruption simulation experiment indicates that the proposed method can realize fast high-precision positioning whereas the carrier-smoothed code differential positioning method needs several hundreds of seconds for obtaining high precision results. We can conclude that a relatively high accuracy and high fixing rate can be achieved for triple-frequency WL method with single-epoch observations, displaying significant advantage comparing to traditional carrier-smoothed code differential positioning method.

  9. Effects of Latent Heating on Atmospheres of Brown Dwarfs and Directly Imaged Planets

    International Nuclear Information System (INIS)

    Tan, Xianyu; Showman, Adam P.

    2017-01-01

    The growing number of observations of brown dwarfs (BDs) has provided evidence for strong atmospheric circulation on these objects. Directly imaged planets share similar observations and can be viewed as low-gravity versions of BDs. Vigorous condensate cycles of chemical species in their atmospheres are inferred by observations and theoretical studies, and latent heating associated with condensation is expected to be important in shaping atmospheric circulation and influencing cloud patchiness. We present a qualitative description of the mechanisms by which condensational latent heating influences circulation, and then illustrate them using an idealized general circulation model that includes a condensation cycle of silicates with latent heating and molecular weight effect due to the rainout of the condensate. Simulations with conditions appropriate for typical T dwarfs exhibit the development of localized storms and east–west jets. The storms are spatially inhomogeneous, evolving on a timescale of hours to days and extending vertically from the condensation level to the tropopause. The fractional area of the BD covered by active storms is small. Based on a simple analytic model, we quantitatively explain the area fraction of moist plumes and show its dependence on the radiative timescale and convective available potential energy (CAPE). We predict that if latent heating dominates cloud formation processes, the fractional coverage area of clouds decreases as the spectral type goes through the L/T transition from high to lower effective temperature. This is a natural consequence of the variation of the radiative timescale and CAPE with the spectral type.

  10. The role of beaver in shaping steelhead trout (Oncorhynchus mykiss) habitat complexity and thermal refugia in a central Oregon stream

    Science.gov (United States)

    Consolati, F.; Wheaton, J. M.; Neilson, B. T.; Bouwes, N.; Pollock, M. M.

    2012-12-01

    The incised and degraded habitat of Bridge Creek, tributary to the John Day River in central Oregon, is thought to be limiting the local population of ESA-listed steelhead trout (Oncorhynchus mykiss). Restoration efforts for this watershed are aimed to improve their habitat through reconnecting the channel with portions of its former floodplain (now terraces) to increase stream habitat complexity and the extent of riparian vegetation. This is being done via the installation of over a hundred beaver dam support (BDS) structures that are designed to either mimic beaver dams or support existing beaver dams. The overall objective of this study is to determine if the BDS structures have had an effect on stream channel habitat complexity and thermal refugia in selected sections of Bridge Creek. Analysis of stream temperature data in restoration treatment and control areas will show the effects of beaver dams on stream temperature. Analysis of aerial imagery and high resolution topographic data will exhibit how the number and types of geomorphic units have changed after the construction of beaver dams. Combined, the results of this research are aimed to increase our understanding of how beaver dams impact fish habitat and stream temperature.

  11. Cognitive changes after carotid artery stenting

    International Nuclear Information System (INIS)

    Grunwald, I.Q.; Politi, M.; Struffert, T.; Krick, C.; Backens, M.; Supprian, T.; Falkai, P.; Reith, W.

    2006-01-01

    We aimed to test changes in cognitive performance after carotid artery stenting (CAS). Ten patients were neuropsychologically tested at least 24 h before and 48 h after CAS. To diminish thromboembolic events, we used a proximal protection device. The following neuropsychological tests were selected: The Mini Mental State Examination (MMSE), symbol digit test and subtests of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) battery (verbal fluency, constructional practice, word list memory and delayed recall). Affective state was determined by the Beck Depression Score (BDS). No patient suffered from depression (BDS <1) or dementia (MMSE 29.9±1.5). Nine of the ten patients (P=0.12) showed increased speed in the Number Connection Test (NCT) (corresponding to trail making test). Most patients showed better or similar results concerning delayed recall (P=0.31). No change was observed in the symbol digit test, word list memory, verbal fluency or constructional practice. Better results concerning NCT and delayed recall after carotid stenting might be due to improved brain perfusion. After CAS, cognitive and memory performance seem to improve. Further studies with different time intervals and more refined testing, as well as perfusion-weighted imaging, are needed. (orig.)

  12. Polymeric Biodegradable Stent Insertion in the Esophagus

    Directory of Open Access Journals (Sweden)

    Kai Yang

    2016-04-01

    Full Text Available Esophageal stent insertion has been used as a well-accepted and effective alternative to manage and improve the quality of life for patients diagnosed with esophageal diseases and disorders. Current stents are either permanent or temporary and are fabricated from either metal or plastic. The partially covered self-expanding metal stent (SEMS has a firm anchoring effect and prevent stent migration, however, the hyperplastic tissue reaction cause stent restenosis and make it difficult to remove. A fully covered SEMS and self-expanding plastic stent (SEPS reduced reactive hyperplasia but has a high migration rate. The main advantage that polymeric biodegradable stents (BDSs have over metal or plastic stents is that removal is not require and reduce the need for repeated stent insertion. But the slightly lower radial force of BDS may be its main shortcoming and a post-implant problem. Thus, strengthening support of BDS is a content of the research in the future. BDSs are often temporarily effective in esophageal stricture to relieve dysphagia. In the future, it can be expect that biodegradable drug-eluting stents (DES will be available to treat benign esophageal stricture, perforations or leaks with additional use as palliative modalities for treating malignant esophageal stricture, as the bridge to surgery or to maintain luminal patency during neoadjuvant chemoradiation.

  13. The VLT/NaCo large program to probe the occurrence of exoplanets and brown dwarfs at wide orbits . III. The frequency of brown dwarfs and giant planets as companions to solar-type stars

    Science.gov (United States)

    Reggiani, M.; Meyer, M. R.; Chauvin, G.; Vigan, A.; Quanz, S. P.; Biller, B.; Bonavita, M.; Desidera, S.; Delorme, P.; Hagelberg, J.; Maire, A.-L.; Boccaletti, A.; Beuzit, J.-L.; Buenzli, E.; Carson, J.; Covino, E.; Feldt, M.; Girard, J.; Gratton, R.; Henning, T.; Kasper, M.; Lagrange, A.-M.; Mesa, D.; Messina, S.; Montagnier, G.; Mordasini, C.; Mouillet, D.; Schlieder, J. E.; Segransan, D.; Thalmann, C.; Zurlo, A.

    2016-02-01

    Context. In recent years there have been many attempts to characterize the occurrence and distribution of stellar, brown dwarf (BD), and planetary-mass companions to solar-type stars with the aim of constraining formation mechanisms. From radial velocity observations a dearth of companions with masses between 10-40 MJupiter has been noticed at close separations, suggesting the possibility of a distinct formation mechanism for objects above and below this range. Aims: We present a model for the substellar companion mass function (CMF). This model consists of the superposition of the planet and BD companion mass distributions, assuming that we can extrapolate the radial velocity measured CMF for planets to larger separations and the stellar companion mass-ratio distribution over all separations into the BD mass regime. By using both the results of the VLT/NaCo large program (NaCo-LP) and the complementary archive datasets, which probe the occurrence of planets and BDs on wide orbits around solar-type stars, we place some constraints on the planet and BD distributions. Methods: We developed a Monte Carlo simulation tool to predict the outcome of a given survey, depending on the shape of the orbital parameter distributions (mass, semimajor axis, eccentricity, and inclination). Comparing the predictions with the results of the observations, we calculate the likelihood of different models and which models can be ruled out. Results: Current observations are consistent with the proposed model for the CMF, as long as a sufficiently small outer truncation radius (≲100 AU) is introduced for the planet separation distribution. Some regions of parameter space can be excluded by the observations. Conclusions: We conclude that the results of the direct imaging surveys searching for substellar companions around Sun-like stars are consistent with a combined substellar mass spectrum of planets and BDs. This mass distribution has a minimum between 10 and 50 MJupiter, in agreement

  14. Edge and core dynamics in harness

    International Nuclear Information System (INIS)

    Ball, R.

    2007-01-01

    Resistive kink oscillations in tokamak plasmas are usually treated as core localized events, yet there there are several mechanisms by which they may interact with the edge dynamics. This suggests that we may regulate edge oscillatory behaviour, or ELMs, by harnessing the natural or contrived sawtooth period and amplitude. In this work I investigate core-edge oscillatory entrainment through direct propagation of heat pulses, inductive coupling, and global higher order resonance effects. In the core of auxiliary heated tokamak plasmas the ineluctable rhythm of slow buildup and rapid conversion of potential energy governs electron and heat radial transport. The growth phase of the sawtooth is accompanied by significant reconnection, then during the collapse the temperature and density in the core fall dramatically. There is evidence from experiments in reversed field pinch devices that ensuing energy fluxes can affect flow shear and confinement at the edge. The basis for this study is the dynamical (BDS) model for edge plasma behavior that was derived from electrostatic resistive MHD equations. The BDS model reflects the major qualitative features of edge dynamics that have been observed, such as L-H transitions and associated ELMs, hysteresis, and spontaneous reversal of poloidal shear flow. Under poorly dissipative conditions the transient behavior of the model can exhibit period-doubling, blue-sky, homoclinic, and other exotic bifurcations. Thus we might ask questions such as: Is it possible to mode-lock the edge dynamics to the core sawteeth? Can we induce, or prevent, a change in direction of shear flow? What about MHD effects? Is core-edge communication one way or is there some feedback? In the simplest prototype for coupled core-edge dynamics I model the sawtooth crash as a periodic power input to the edge potential energy reservoir. This is effected by coupling the BDS model to the dynamical system u = u(1 - u 2 - x 2 ) - ω s x, x = x(1-u 2 -x 2 ) + ω s u

  15. THE DYNAMICAL EVOLUTION OF LOW-MASS HYDROGEN-BURNING STARS, BROWN DWARFS, AND PLANETARY-MASS OBJECTS FORMED THROUGH DISK FRAGMENTATION

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yun; Kouwenhoven, M. B. N. [Department of Astronomy, School of Physics, Peking University, Yiheyuan Lu 5, Haidian Qu, Beijing 100871 (China); Stamatellos, D. [Jeremiah Horrocks Institute for Mathematics, Physics and Astronomy, University of Central Lancashire, Preston, PR1 2HE (United Kingdom); Goodwin, S. P., E-mail: yunli@pku.edu.cn [Department of Physics and Astronomy, The University of Sheffield, Hicks Building, Hounsfield Road, Sheffield S3 7RH (United Kingdom)

    2015-06-01

    Theory and simulations suggest that it is possible to form low-mass hydrogen-burning stars, brown dwarfs (BDs), and planetary-mass objects (PMOs) via disk fragmentation. As disk fragmentation results in the formation of several bodies at comparable distances to the host star, their orbits are generally unstable. Here, we study the dynamical evolution of these objects. We set up the initial conditions based on the outcomes of the smoothed-particle hydrodynamics simulations of Stamatellos and Whitworth, and for comparison we also study the evolution of systems resulting from lower-mass fragmenting disks. We refer to these two sets of simulations as set 1 and set 2, respectively. At 10 Myr, approximately half of the host stars have one companion left, and approximately 22% (set 1) to 9.8% (set 2) of the host stars are single. Systems with multiple secondaries in relatively stable configurations are common (about 30% and 44%, respectively). The majority of the companions are ejected within 1 Myr with velocities mostly below 5 km s{sup −1}, with some runaway escapers with velocities over 30 km s{sup −1}. Roughly 6% (set 1) and 2% (set 2) of the companions pair up into very low-mass binary systems, resulting in respective binary fractions of 3.2% and 1.2%. The majority of these pairs escape as very low-mass binaries, while others remain bound to the host star in hierarchical configurations (often with retrograde inner orbits). Physical collisions with the host star (0.43 and 0.18 events per host star for set 1 and set 2, respectively) and between companions (0.08 and 0.04 events per host star for set 1 and set 2, respectively) are relatively common and their frequency increases with increasing disk mass. Our study predicts observable properties of very low-mass binaries, low-mass hierarchical systems, the BD desert, and free-floating BDs and PMOs in and near young stellar groupings, which can be used to distinguish between different formation scenarios of very low

  16. The Impact of Satellite Time Group Delay and Inter-Frequency Differential Code Bias Corrections on Multi-GNSS Combined Positioning.

    Science.gov (United States)

    Ge, Yulong; Zhou, Feng; Sun, Baoqi; Wang, Shengli; Shi, Bo

    2017-03-16

    We present quad-constellation (namely, GPS, GLONASS, BeiDou and Galileo) time group delay (TGD) and differential code bias (DCB) correction models to fully exploit the code observations of all the four global navigation satellite systems (GNSSs) for navigation and positioning. The relationship between TGDs and DCBs for multi-GNSS is clearly figured out, and the equivalence of TGD and DCB correction models combining theory with practice is demonstrated. Meanwhile, the TGD/DCB correction models have been extended to various standard point positioning (SPP) and precise point positioning (PPP) scenarios in a multi-GNSS and multi-frequency context. To evaluate the effectiveness and practicability of broadcast TGDs in the navigation message and DCBs provided by the Multi-GNSS Experiment (MGEX), both single-frequency GNSS ionosphere-corrected SPP and dual-frequency GNSS ionosphere-free SPP/PPP tests are carried out with quad-constellation signals. Furthermore, the author investigates the influence of differential code biases on GNSS positioning estimates. The experiments show that multi-constellation combination SPP performs better after DCB/TGD correction, for example, for GPS-only b1-based SPP, the positioning accuracies can be improved by 25.0%, 30.6% and 26.7%, respectively, in the N, E, and U components, after the differential code biases correction, while GPS/GLONASS/BDS b1-based SPP can be improved by 16.1%, 26.1% and 9.9%. For GPS/BDS/Galileo the 3rd frequency based SPP, the positioning accuracies are improved by 2.0%, 2.0% and 0.4%, respectively, in the N, E, and U components, after Galileo satellites DCB correction. The accuracy of Galileo-only b1-based SPP are improved about 48.6%, 34.7% and 40.6% with DCB correction, respectively, in the N, E, and U components. The estimates of multi-constellation PPP are subject to different degrees of influence. For multi-constellation combination SPP, the accuracy of single-frequency is slightly better than that of dual

  17. Effect of Heat Moisture Exchanger on Aerosol Drug Delivery and Airway Resistance in Simulated Ventilator-Dependent Adults Using Jet and Mesh Nebulizers.

    Science.gov (United States)

    Ari, Arzu; Dang, Truong; Al Enazi, Fahad H; Alqahtani, Mohammed M; Alkhathami, Abdulrahman; Qoutah, Rowaida; Almamary, Ahmad S; Fink, James B

    2018-02-01

    Placement of a heat moisture exchanger (HME) between aerosol generator and patient has been associated with greatly reduced drug delivery. The purpose of this study was to evaluate the effect of filtered and nonfiltered HMEs placed between nebulizer and patient on aerosol deposition and airway resistance (Raw) in simulated ventilator-dependent adults. An in vitro lung model was developed to simulate a mechanically ventilated adult (Vt 500 mL, RR 15/min, and PEEP 5 cmH 2 O, using two inspiratory flow rates 40 and 50 L/min) using an intubated adult manikin with an endotracheal tube (8 mmID). The bronchi of the manikin were connected to a Y-adapter through a collecting filter (Respirgard II) attached to a test lung through a heated humidifier (37°C producing 100% relative humidity) to simulate exhaled humidity. For treatment conditions, a nonfiltered HME (ThermoFlo™ 6070; ARC Medical) and filtered HMEs (ThermoFlo™ Filter; ARC Medical and PALL Ultipor; Pall Medical) were placed between the ventilator circuit at the endotracheal tube and allowed to acclimate to the exhaled heat and humidity for 30 minutes before aerosol administration. Airway resistance (cmH 2 O/L/s) was taken at 0, 10, 20, and 30 minutes after HME placement and after each of four aerosol treatments. Albuterol sulfate (2.5 mg/3 mL) was administered with jet (Misty Max 10; Airlife) and mesh (Aerogen Solo; Aerogen) nebulizers positioned in the inspiratory limb proximal to the Y-adapter. Control consisted of nebulization with no HME. Drug was eluted from filter at the end of the trachea and measured using spectrophotometry (276 nm). Greater than 60% of the control dose was delivered through the ThermoFlo. No significant difference was found between the first four treatments given by the jet (p = 0.825) and the mesh (p = 0.753) nebulizers. There is a small increase in Raw between pre- and post-four treatments with the jet (p = 0.001) and mesh (p = 0.015) nebulizers. Aerosol

  18. A review of specialist palliative care provision and access across London - mapping the capital.

    Science.gov (United States)

    Cox, Sarah; Murtagh, Fliss E M; Tookman, Adrian; Gage, Andrew; Sykes, Nigel; McGinn, Maureen; Kathoria, Meeta; Wilderspin, Hilary; Chart, Liz

    2017-05-01

    Palliative care provision varies by diagnosis, geography, and setting. The Minimum Data-set provides high-level data on provision, but comprehensive comparative information about specialist palliative care (SPC) provision is lacking. The London Cancer Alliance - now RM Partners' Accountable Cancer Network - palliative care group (West/South London) and PallE8 (North/East London), with Marie Curie, sought to address this gap. The aim was to provide comparative data on SPC provision across London to support commissioners and providers to assess provision, identify gaps, and reduce inequity. A data-collection template was developed through expert consensus. Demographic, diagnostic, and service data was collected, plus models of care, staffing levels, and use of clinical outcome/experience measures. Results were collated by organisation and CCG. Cleaned data was provided back to each organisation for verification before final analyses. All 50 adult SPC providers in London participated, representing hospitals, hospices and community services. •Patients in all 32 CCGs have access to hospice beds, with 322 beds from 15 providers (4 NHS) for a population of 9,323,570 (with 47,583 deaths annually).•SPC in London sees more non-cancer patients than is reported nationally; 79% of hospital advisory, 74% of community, and 88% of hospice in-patient services have higher proportions of non-cancer patients.•Considerable variation in out-of-hours availability of both hospital SPC and community SPC services across London; only 9 of 30 hospital and 17 of 26 community services provide seven-day visiting.•Wide variation in the models of community-based SPC; proportions of community patients attending day services vary from 1 in 4, to 1 in 17, just 13 CCGs have H@H-type provision, with few Rapid Response or Care Coordination services. This detailed survey demonstrates important gaps in availability and provision of SPC services. Recommendations are made for commissioners and

  19. High-Performance Palladium Based Membrane for Hydrogen Separation and Purification

    Energy Technology Data Exchange (ETDEWEB)

    Hopkins, Scott

    2012-01-31

    The mission of the DOE's Fuel Cell Technologies'Hydrogen Fuels R&D effort is to research, develop, and validate technologies for producing, storing, and delivering hydrogen in an efficient, clean, safe, reliable, and affordable manner. A key program technical milestone for hydrogen technology readiness is to produce hydrogen from diverse, domestic resources at $2.00-$3.00 per gallon of gasoline equivalent (gge) delivered, untaxed. Low-cost, high-temperature hydrogen separation membranes represent a key enabling technology for small-scale distributed hydrogen production units. Availability of such membranes with high selectivity and high permeability for hydrogen will allow their integration with hydrocarbon reforming and water gas shift reactions, potentially reducing the cost of hydrogen produced. Pd-metal-based dense membranes are known for their excellent hydrogen selectivity and permeability characteristics, however, utilization of these membranes has so far been limited to small scale niche markets for hydrogen purification primarily due to the relatively high cost of Pd-alloy tubes compared to pressure swing adsorption (PSA) units. This project was aimed at development of thin-film Pd-alloy membranes deposited on Pall Corporation's DOE-based AccuSep® porous metal tube substrates to form a composite hydrogen separation membrane for these applications. Pall's composite membrane development addressed the typical limitations of composite structures by developing robust membranes capable of withstanding thermal and mechanical stresses resulting from high temperature (400C), high pressure (400 psi steam methane reformer and 1000 psi coal) operations and thermal cycling involved in conventional hydrogen production. In addition, the Pd-alloy membrane composition was optimized to be able to offer the most stability in the typical synthesis gas environments produced by reforming of natural gas and bio-derived liquid fuels (BILI) validating the

  20. para-Benzene disulfonic acid and its tetrachloro and tetrafluoro derivatives--studies towards polyhalogenated metal-organic-frameworks with sulfo analogues of terephthalic acid.

    Science.gov (United States)

    Muesmann, Thomas W T; Zitzer, Christina; Mietrach, Andrea; Klüner, Thorsten; Christoffers, Jens; Wickleder, Mathias S

    2011-04-07

    We developed convenient synthetic routes for the preparation of para-benzene disulfonic acid (H(2)BDS) and its tetrachloro (H(2)BDSCl(4)) and tetrafluoro (H(2)BDSF(4)) derivatives. The reaction of these acids with zinc nitrate in DMF led to single crystals of [Zn(BDS)(DMF)(2)] (triclinic, P ̄1[combining macron], Z=2, a=976.62(4), b=986.85(4), c=1014.40(4), α=69.106(2)°, β=68.746(2)°, γ=86.295(2)°, wR(2)=0.0627), [Zn(BDSCl(4))(DMF)(4)] (triclinic, P ̄1[combining macron], Z=1, a=831.5(1), b=905.2(1), c=989.6(1), α=90.44(2)°, β=91.41 (2)°, γ=106.72(2)°, wR(2)=0.0635), and [Zn(BDSF(4))(DMF)(4)] (monoclinic, P2(1)/c, Z=2, a=889.01(3), b=968.91(3), c=1633.07(5) pm, β=106.524(2)°, wR(2)=0.0948). While [Zn(BDS)(DMF)(2)] exhibits a layer structure, the disulfonate linkers connect the zinc ions into chains in the crystal structures of [Zn(BDSCl(4))(DMF)(4)] and [Zn(BDSF(4))(DMF)(4)]. Thermoanalytical investigations revealed that desolvation of the compounds occurs in a temperature range between 100 and 200 °C. The solvent free sulfonates show remarkably high stabilities, [Zn(BDS)(DMF)(2)] is stable up to nearly 600 °C. The halogenated acids were also used to prepare copper salts from aqueous solutions and Cu(2)(OH)(2)(CO(3)) (malachite) as a copper source. The crystal structure of [Cu(H(2)O)(6)](BDSF(4)) (triclinic, P ̄1[combining macron], Z=1, a=510.45(2), b=744.68(3), c=1077.77(4) pm, α=85.627 (2)°, β=77.449 (2)°, γ=76.015 (2)°) exhibits complex cations and uncoordinated sulfonate anions, while in [Cu(BDSCl(4))(H(2)O)(4)] (orthorhombic, Pnma, Z=4, a=721.27(2), b=2147.81(6), c=979.42(3) pm) the Cu(2+) ions are linked to infinite chains in the crystal structure. The most interesting structural feature of [Cu(BDSCl(4))(H(2)O)(4)] is the significant deviation from planarity of the disulfonate dianion. Theoretical investigations revealed that a boat conformation is favoured due to steric hindrance in cases where a syn coordination of the sulfonate

  1. Simulation of Wakefield Effect in ILC IR Chamber

    Energy Technology Data Exchange (ETDEWEB)

    Pei, S; Seryi, A.; Raubenheimer, T.O.; /SLAC

    2008-06-26

    To achieve super high luminosity, high current beams with very short bunch length are needed, which carry high intensity EM fields. For ILC, two bunch trains with bunch length of 300 {micro}m and bunch charge of 3.2nC are needed to collide at the IR to achieve the ILC luminosity goals. When the 300 {micro}m bunches pass through the IR chamber, wakefields will be excited, which will cause HOM power flowing through the IR chamber beam pipe to the final doublets due to the high frequency characteristic of the induced wakefields. Since superconducting technology is adopted for the final doublets of ILC BDS, whose operation stability might be affected by the HOM power produced at the IR chamber, quench might happen. In this paper, we did some analytical estimation and numerical simulation on the wakefield effects in ILC IR chamber.

  2. Status of Ground Motion Mitigation Techniques for CLIC

    CERN Document Server

    Snuverink, J; Collette, C; Duarte Ramos, F; Gaddi, A; Gerwig, H; Janssens, S; Pfingstner, J; Schulte, D; Balik, G; Brunetti, L; Jeremie, A; Burrows, P; Caron, B; Resta-Lopez, J

    2011-01-01

    The Compact Linear Collider (CLIC) accelerator has strong stability requirements on the position of the beam. In particular, the beam position will be sensitive to ground motion. A number of mitigation techniques are proposed - quadrupole stabilisation and positioning, final doublet stabilisation as well as beam based orbit and interaction point (IP) feedback. Integrated studies of the impact of the ground motion on the CLIC Main Linac (ML) and Beam Delivery System (BDS) have been performed, which model the hardware and beam performance in detail. Based on the results future improvements of the mitigation techniques are suggested and simulated. It is shown that with the current design the tight luminosity budget for ground motion effects is fulfilled and accordingly, an essential feasibility issue of CLIC has been addressed.

  3. A prototype cavity beam position monitor for the CLIC Main Beam

    CERN Document Server

    Cullinany , F; Joshi, N; Lyapin, A; Bastard, D; Calvo, E; Chritin, N; Guillot-Vignot, F; Lefevre, T; Søby, L; Wendt, M; Lunin, A; Yakovlev, V P; Smith, S

    2012-01-01

    The Compact Linear Collider (CLIC) places unprecedented demands on its diagnostics systems. A large number of cavity beam position monitors (BPMs) throughout the main linac and beam delivery system (BDS) must routinely perform with 50 nm spatial resolution. Multiple position measurements within a single 156 ns bunch train are also required. A prototype low-Q cavity beam position monitor has been designed and built to be tested on the CLIC Test Facility (CTF3) probe beam. This paper presents the latest measurements of the prototype cavity BPM and the design and simulation of the radio frequency (RF) signal processing electronics with regards to the final performance. Installation of the BPM in the CTF3 probe beamline is also discussed.

  4. Abnormal Uterine Bleeding including coagulopathies and other menstrual disorders.

    Science.gov (United States)

    Deligeoroglou, Efthimios; Karountzos, Vasileios

    2018-04-01

    Abnormal Uterine Bleeding (AUB) is a frequent cause of visits to the emergency department and a major reason for concern among adolescents and their families. The most common cause of AUB, in otherwise healthy adolescents, is ovulatory dysfunction, although 5-36% of adolescents who present with heavy menstrual bleeding, have an underlying bleeding disorder (BD). The most common form of BDs is von Willebrand Disease, reflecting 13% of adolescents with AUB. Management of AUB depends on the underlying etiology, the bleeding severity, as well as the need for hospitalization. Treatment of adolescents with an underlying coagulopathy depends on the severity of the BD, while therapeutic interventions are summarized in supportive measures, hormonal treatments (e.g. Combined Oral Contraceptives), non-hormonal treatments (e.g. tranexamic acid and desmopressin), surgical options (e.g. dilatation & curettage) and treatment options in specific conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Biological Threats Detection Technologies

    International Nuclear Information System (INIS)

    Bartoszcze, M.

    2007-01-01

    Among many decisive factors, which can have the influence on the possibility of decreases the results of use biological agents should be mentioned obligatory: rapid detection and identification of biological factor used, the proper preventive treatment and the medical management. The aims of identification: to identify the factor used, to estimate the area of contamination, to evaluate the possible countermeasure efforts (antibiotics, disinfectants) and to assess the effectiveness of the decontamination efforts (decontamination of the persons, equipment, buildings, environment etc.). The objects of identification are: bacteria and bacteria's spores, viruses, toxins and genetically modified factors. The present technologies are divided into: based on PCR techniques (ABI PRISM, APSIS, BIOVERIS, RAPID), immuno (BADD, RAMP, SMART) PCR and immuno techniques (APDS, LUMINEX) and others (BDS2, LUNASCAN, MALDI). The selected technologies assigned to field conditions, mobile and stationary laboratories will be presented.(author)

  6. A New Validated RP- HPLC Method for the Determination of Nevirapine in Human Plasma

    Directory of Open Access Journals (Sweden)

    C. H. Venkata Kumar

    2010-01-01

    Full Text Available A rapid, selective and sensitive high performance liquid chromatographic method for the estimation of nevirapine in human plasma has been developed. Chromatography was carried out on a Hypersil BDS C18 column using a mixture of ammonium acetate buffer (pH 4.0 ± 0.05 and acetonitrile (85:15 v/v as the mobile phase. The eluents were monitored for the drug by UV detection at 254 nm. Oxcarbazepine was used as an internal standard for this study. The retention times for nevirapine and oxcarbazepine were found to be 7.2 and 14.7 min respectively. The method was found to be linear in the concentration range of 50 ng/mL to 5003.7 ng/mL. The method was validated as per FDA guidelines and was found to be suitable for bioequivalence and pharmacokinetic studies.

  7. Removal of sulfur-containing organic molecules adsorbed on inorganic supports by Rhodococcus Rhodochrous spp.

    Science.gov (United States)

    Carvajal, P; Dinamarca, M Alejandro; Baeza, P; Camú, E; Ojeda, J

    2017-02-01

    To remove dibenzothiophene (DBT) and 4,6-dimethyl-dibenzothiophene (4,6-DMDBT) adsorbed on alumina, silica and sepiolite through biodesulfurization (BDS) using Rhodococcus Rhodochrous spp., that selectively reduce sulfur molecules without generating of gaseous pollutants. The adsorption of DBT and 4,6-DMDBT was affected by the properties of the supports, including particle size and the presence of surface acidic groups. The highest adsorption of both sulfur-containing organic molecules used particle sizes of 0.43-0.063 mm. The highest percentage removal was with sepiolite (80 % for DBT and 56 % for 4,6-DMDBT) and silica (71 % for DBT and 37 % for 4,6-DMDBT). This is attributed to the close interaction between these supports and the bacteria. Biodesulfurization is effective for removing the sulfur-containing organic molecules adsorbed on inorganic materials and avoids the generation of gaseous pollutants.

  8. Optimization of nicotinamide and riboflavin in the biodesulfurization of dibenzothiophene using response surface methodology

    Directory of Open Access Journals (Sweden)

    Hossein Saber

    2013-01-01

    Full Text Available Introduction: Dibenzothiophene (DBT is a sulfuric compound and resistant to Hydrodesulfurization process.Rhodococcuserythropolis R1, a previously isolated bacterial strain, is capable to bioconversion of DBT to 2-hydroxybiphenyl (2-HBP.Materials and methods: The effect of nicotinamide (precursor of NAD and riboflavin (precursor of FMN on DBT biodesulfurization and growth rate by this strain was studied using Gibbs assay and turbidimeteric assay respectively. The level of cofactor precursors were optimized using response surface methodology (RSM. Results: Analyses showed that both nicotinamide and riboflavin were statistically significant and could enhance the biodesulfurization rate of DBT by induction of dsz operon. The optimum level of nicotinamide and riboflavin was obtained at 10.67 mM and 34.2 µM respectively. Discussion and conclusion: In spite of increasing in BDS, the addition of these cofactor precursors led to decreased growth rate and biomass production due to limitated effect of produced 2-HBP.

  9. A Measurement Of The Branching Fraction Of The D(s) Meson Decay Into A Tau And A Neutrino

    CERN Document Server

    He, L H

    2000-01-01

    The purely leptonic decay Ds-->tn is studied in a sample of four million hadronic Z0 decays collected in 1991-1995 with the ALEPH detector at LEP. A linear discriminant analysis is performed to form an optimal set of discriminant variables. The total number of signal events is extracted from an unbinned maximum likelihood fit to the two dimensional discriminant variable distribution. The branching fractions are measured from the two leptonic decay channels of the t lepton to be B(Ds--> tn)e=0 .0586+/-0.0118(stat )+/-0.0209( syst), B(Ds-->tn )m=0.0578+/-0.0085 (stat)+/- 0.0176(syst) . The combined result is B(Ds-->tn )=0.0579+/-0.0076( stat)+/-0.0178( syst). Within the Standard Model, the result corresponds to a D s decay constant of fDs=273+/- 18(stat)+/-42( syst)MeV.

  10. New titrimetric method for oxygen to metal ratio in uranium oxide powders

    International Nuclear Information System (INIS)

    Ray, Vinod Kumar; Brahmananda Reddy, G.; Balaji Rao, Y.; Subba Rao, Y.

    2015-01-01

    O/U ratio is of high importance to both U 3 O 8 and UO 2 powders for different reasons. In UO 2 powder it is a guiding parameter for sintering process where as for U 3 O 8 , it indicates efficiency of ammonium di-uranate (ADU) to U 3 O 8 conversion process. In the present method for O/U determination, UO 2 and U 3 O 8 powders are dissolved in 4.5 M sulphuric acid and little HF by heating on hot plate. Subsequently, optimized quantity of phosphoric acid is added on cooling, for getting sharp end point. The resultant solution is titrated with standard potassium dichromate using barium diphenylamine sulphonate (BDS) as an indicator. The expanded uncertainties calculated for UO 2 and U 3 O 8 powders are ±0.004 and ±0.006 O/U ratio units respectively at 95 % confidence level. (author)

  11. [Analysis of chemical constituents from Citrus aurantium by UHPLC-LTQ-Orbitrap-MS/MS].

    Science.gov (United States)

    Yu, Guo-Hua; Yang, Hong-Jun; Li, Jun-Fang; Geng, Ya; Dong, Ling; Xu, Hai-Yu

    2016-09-01

    In this study, a ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS/MS) method was developed to analyze the chemical components in Citrus aurantium. C. aurantium were extracted with 75% methanol, and we applied a Thermo Scientific BDS Hypersil C₁₈ column (2.1 mm×150 mm, 2.4 μm) to UHPLC analysis with acetonitrile-water (containing 0.1% formic acid) in gradient as mobile phase. Elutes were then detected by ESI-LTQ-Orbitrap-MS/MS. A total of 27 components were identified, including fourteen flavonoids, seven coumarins, five limonoids and one alkaloid. This study showed an insight into the composition of C. aurantium, which could provide theoretical foundation for further study and utilization of the medicinal resources. Copyright© by the Chinese Pharmaceutical Association.

  12. Student-led oral health education for the homeless community of East London.

    Science.gov (United States)

    Pritchett, R M; Hine, C E; Franks, M A; Fisher-Brown, L

    2014-07-01

    Within the BDS curriculum, dental public health and the importance of social responsibility is clearly emphasised though often in a didactic manner, without practical application. Preventative concepts are taught and relayed to individual patients being treated within a dental school. The impact of oral disease on general health within disadvantaged communities is a problem commonly addressed by healthcare professionals. Part of this responsibility should be shared with and experienced by the next generation of dental practitioners through health education outreach programmes within the undergraduate curriculum. Not only will this benefit recipients within disadvantaged populations such as the homeless, but it will also develop and encourage a philosophy of social responsibility throughout the future careers of undergraduate dental and hygiene/therapy students. To explore the feasibility of achieving this objective, we devised an oral health awareness programme to address the needs of 'hard to reach' homeless people within the communities served by the Community Dental Service of Tower Hamlets, City and Hackney, London.

  13. Continuing professional development of dentists through distant learning: An Indira Gandhi National Open University-Dental Council of India experiment a report

    Directory of Open Access Journals (Sweden)

    Ruchika Kuba

    2014-01-01

    Full Text Available To keep themselves updated with all the advancements in the field of dentistry, dentists should involve themselves in some kind of professional development. Distance learning is the most appropriate way to serve the growing demand due to technological advancements. Indira Gandhi National Open University in collaboration with Dental Council of India (DCI developed and launched two continuing professional development programs in Endodontics (postgraduate certificate in endodontics and postgraduate certificate in oral implantology and has trained over 400 and 280 BDS dentists respectively till date. The program package consists of self-instructional material, assignments, videos and practical training. The training is conducted in premiere dental colleges and institutions recognized by DCI. The certificate is awarded after a term end examination, both in theory and practical. The pass percentages of the theory courses ranged from around 63% to 98%, and 90% of the candidates cleared the practical exam.

  14. Stability-indicating RP-HPLC method for simultaneous determination of gatifloxacin and flurbiprofen in binary combination

    Directory of Open Access Journals (Sweden)

    Islam Ullah Khan

    2014-04-01

    Full Text Available A stability-indicating RP-HPLC method is presented for determination of gatifloxacin and flurbiprofen in binary combination. Gatifloxacin, flurbiprofen and their degradation products were detected at 254 nm using a BDS Hypersil C8 (250 X 4.6 mm, 5 µm column and mixture of 20 mM phosphate buffer (pH 3.0 and methanol 30:70 v/v as mobile phase. Response was linear over the range of 15-105 mg mL-1 for gatifloxacin (r² > 0.998 and of 1.5-10.5 mg mL-1 for flurbiprofen (r² > 0.999. The developed method efficiently separated the analytical peaks from degradation products (peak purity index > 0.9999. The method developed can be applied successfully for determination of gatifloxacin and flurbiprofen in human serum, urine, pharmaceutical formulations, and their stability studies.

  15. Research of small house hold sewage treatment plant working

    Directory of Open Access Journals (Sweden)

    Ernesta Valeikaitė

    2015-10-01

    Full Text Available In Lithuania centralized municipal wastewater treatment technologies are applied quite effectively, but there is little evidence of the functioning of individual small wastewater treatment plants. The paper presents the small device AT-6, in the city of Vilnius, and the treated sewage results (BDS7, nitrate, ammonium, total nitrogen, total phosphorus and phosphate concentrations. Studies have shown that treated sewage indicators based on ammonium and nitrate ion concentrations are good. These substances are 2–10 times less than it can be in drinking water according to HN 24: 2003. Concentration of phosphates in the treated sewage ranged from 3.57 to 9.33 mg/L and exceeded the indicators, which were compared. The phosphorus environmental aspect is not dangerous, because treated sewage is not discharged into surface water bodies. Dealing from the pattern of biological indicators and enzymatic activity, the quality of activated sludge is good. Treated sewage does not impair the natural state.

  16. Depressão e qualidade de vida em indivíduos com artrite reumatoide e indivíduos com saúde estável: um estudo comparativo

    OpenAIRE

    Campos, Anna Paula Ribeiro; Silva, Cinthia Maria; Castro, Shamyr Sulyvam de; Graminha, Cristiane Vitaliano

    2013-01-01

    O objetivo deste estudo foi verificar a ocorrência de depressão e alterações da qualidade de vida (QV) em indivíduos com artrite reumatoide (AR).Participaram da pesquisa 60 indivíduos, divididos em 2 grupos com 30 cada, sendo o Grupo Teste composto por indivíduos com AR e o Grupo Controle composto por indivíduos com saúde estável. A QV foi avaliada pelo Medical Outcomes Study 36-Item Short-Form Healthy Survey (SF-36) e a depressão, pela Escala de Depressão de Beck (BDS). Para estabelecer comp...

  17. Study of neutron fields around an intense neutron generator.

    Science.gov (United States)

    Kicka, L; Machrafi, R; Miller, A

    2017-12-01

    Neutron fields in the vicinity of the newly built neutron facility, at the University of Ontario Institute of Technology (UOIT), have been investigated in a series of Monte Carlo simulations and measurements. The facility hosts a P-385 neutron generator based on a deuterium-deuterium fusion reaction. The neutron fluence at different locations around the neutron generator facility has been simulated using MCNPX 2.7E Monte Carlo particle transport program. To characterize neutron fields, three neutron sources were modeled with distributions corresponding to different incident deuteron energies of 90kV, 110kV, and 130kV. Measurements have been carried out to determine the dose rate at locations adjacent to the generator using bubble detectors (BDs). The neutron intensity was evaluated and the total dose rates corresponding to different applied acceleration potentials were estimated at various locations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. [Determination of aspirin and free salicylic acid in lysinipirine injection by high performance liquid chromatography].

    Science.gov (United States)

    Dong, Yu; Zhao, Yuan-zheng; Zhang, Yi-na

    2002-05-01

    The contents of aspirin and free salicylic acid in lysinipirine injection were determined by high performance liquid chromatography (HPLC). A Hypersil BDS C18 column was used with the mobile phase of methanol-water-acetic acid (35:65:3, volume ratio) and the detection wavelength of 280 nm. The average recoveries of aspirin and salicylic acid added were 99.27% (RSD = 0.8%) and 99.61%(RSD = 1.3%), respectively. The calibration curves had good linearity in the range of 0.028 g/L -0.141 mg/L and 0.77 mg/L -3.85 mg/L, and the correlation coefficients were 0.9999 and 0.9998 for aspirin and salicylic acid respectively.

  19. THE ROLE OF STUDENT CHARACTERISTICS IN PROBLEM BASED LEARNING

    Directory of Open Access Journals (Sweden)

    Mia Damiyanti

    2006-04-01

    Full Text Available To reach the effectiveness of study, it is recommended to work on active learning method. The learning activity must be done with emphasis on the students’ characteristics. The characteristic means internal factors (cognitive entry behavior and affective entry characteristics, which are considered important as solving problems. The previous studies have shown that there is a correlation between achievement test and students’ characteristic entry behavior. At the beginning of the academic year of 2003, Faculty of Dentistry, University of Indonesia started active learning with PBL curriculum for the BDS degree. From a study about the correlation between the achievement and students’ entry behavior (previous knowledge, self concept, attitude, and anxiety during attending the test the study showed that characteristic entry behavior contributes to the student’s achievement test. The results supported the previous study.

  20. Assessment of Multiple GNSS Real-Time SSR Products from Different Analysis Centers

    Directory of Open Access Journals (Sweden)

    Zhiyu Wang

    2018-03-01

    Full Text Available The real-time State Space Representation (SSR product of the GNSS (Global Navigation Satellite System orbit and clock is one of the most essential corrections for real-time precise point positioning (PPP. In this work, the performance of current SSR products from eight analysis centers were assessed by comparing it with the final product and the accuracy of real-time PPP. Numerical results showed that (1 the accuracies of the GPS SSR product were better than 8 cm for the satellite orbit and 0.3 ns for the satellite clock; (2 the accuracies of the GLONASS (GLObalnaya NAvigatsionnaya Sputnikovaya Sistema SSR product were better than 10 cm for orbit RMS (Root Mean Square and 0.6 ns for clock STD (Standard Deviation; and (3 the accuracies of the BDS (BeiDou Navigation Satellite System and Galileo SSR products from CLK93 were about 14.54 and 4.42 cm for the orbit RMS and 0.32 and 0.18 ns for the clock STD, respectively. The simulated kinematic PPP results obtained using the SSR products from CLK93 and CLK51 performed better than those using other SSR products; and the accuracy of PPP based on all products was better than 6 and 10 cm in the horizontal and vertical directions, respectively. The real-time kinematic PPP experiment carried out in Beijing, Tianjin, and Shijiazhuang, China indicated that the SSR product CLK93 from Centre National d’Etudes Spatiales (CNES had a better performance than CAS01. Moreover, the PPP with GPS + BDS dual systems had a higher accuracy than those with only a GPS single system.

  1. Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract.

    Directory of Open Access Journals (Sweden)

    Brian Becknell

    Full Text Available Beta defensins (BDs are cationic peptides with antimicrobial activity that defend epithelial surfaces including the skin, gastrointestinal, and respiratory tracts. However, BD expression and function in the urinary tract are incompletely characterized. The purpose of this study was to describe Beta Defensin-1 (BD-1 expression in the lower urinary tract, regulation by cystitis, and antimicrobial activity toward uropathogenic Escherichia coli (UPEC in vivo. Human DEFB1 and orthologous mouse Defb1 mRNA are detectable in bladder and ureter homogenates, and human BD-1 protein localizes to the urothelium. To determine the relevance of BD-1 to lower urinary tract defense in vivo, we evaluated clearance of UPEC by Defb1 knockout (Defb1(-/- mice. At 6, 18, and 48 hours following transurethral UPEC inoculation, no significant differences were observed in bacterial burden in bladders or kidneys of Defb1(-/- and wild type C57BL/6 mice. In wild type mice, bladder Defb1 mRNA levels decreased as early as two hours post-infection and reached a nadir by six hours. RT-PCR profiling of BDs identified expression of Defb3 and Defb14 mRNA in murine bladder and ureter, which encode for mBD-3 and mBD-14 protein, respectively. MBD-14 protein expression was observed in bladder urothelium following UPEC infection, and both mBD-3 and mBD-14 displayed dose-dependent bactericidal activity toward UPEC in vitro. Thus, whereas mBD-1 deficiency does not alter bladder UPEC burden in vivo, we have identified mBD-3 and mBD-14 as potential mediators of mucosal immunity in the lower urinary tract.

  2. Effect of Concomitant Birth Defects and Genetic Anomalies on Infant Mortality in Tetralogy of Fallot.

    Science.gov (United States)

    Jernigan, Eric G; Strassle, Paula D; Stebbins, Rebecca C; Meyer, Robert E; Nelson, Jennifer S

    2017-08-15

    A substantial proportion of infants born with tetralogy of Fallot (TOF) die in infancy. A better understanding of the heterogeneity associated with TOF, including extracardiac malformations and chromosomal anomalies is vital to stratifying risk and optimizing outcomes during infancy. Using the North Carolina Birth Defects Monitoring Program, infants diagnosed with TOF and born between 2003 and 2012 were included. Kaplan-Meier survival curves were used to estimate cumulative 1-year mortality, stratified by the presence of concomitant birth defects (BDs) and chromosomal anomalies. Multivariable logistic regression was used to estimate the direct effect of each concomitant BD, after adjusting for all others. A total of 496 infants with TOF were included, and 15% (n = 76) died. The number of concomitant BD systems was significantly associated with the risk of death at 1-year, p < 0.0001. Specifically, the risk of mortality was 8% among infants with TOF with or without additional cardiac defects, 16% among infants with TOF and 1 extracardiac BD system, 19% among infants with 2 extracardiac BD systems, and 39% among infants with ≥ 3 extracardiac BD systems. After adjustment, concomitant eye and gastrointestinal defects were significantly associated increased with 1-year mortality, odds ratio 2.83 (95% confidence interval, 1.08-7.32) and odds ratio 4.43 (95% confidence interval, 1.57, 12.45), respectively. Infants with trisomy 13 or trisomy 18 were also significantly more likely to die, p < 0.0001. Both concomitant BDs and genetic anomalies increase the risk of mortality among infants with TOF. Future studies are needed to identify the underlying genetic and socioeconomic risk factors for high-risk TOF infants. Birth Defects Research 109:1154-1165, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  3. Validation of the Revised Illness Perception Questionnaire in Turkish epilepsy patients and the effects of earthquake experience on perception of disease.

    Science.gov (United States)

    Keskin Güler, Selda; Güler, Sertac; Gökçe Çokal, Burcu; Gunes, Nalan; Yon, Mehmet İlker; Yoldas, Tahir Kurtulus

    2017-01-01

    The aims of this study were to investigate the reliability of the Revised Illness Perception Questionnaire (IPQ-R) in Turkish patients with epilepsy (PWE) and to determine the effects of earthquake experience on the perception of disease in patients. The sample was composed of 48 PWE, who were affected by the 2011 earthquake (n=21) or who had never had any earthquake experience (n=27). The interview form, IPQ-R, and Beck Depression Scale (BDS) were applied. The study was carried out on PWE whose mean age was 20.9 years (±8.1 years) and who had been diagnosed within the last 10 years (±6.9 years). IPQ-R consisted of three parts: illness identity, attributions concerning the disease, and probable causes. In the part of illness identity, the most frequently met manifestations were fatigue (76.6%) and headache (72.9%). Regarding attributions concerning the disease and probable causes, the test was determined to be reliable (reliability coefficient 0.715-0.814). In terms of personal control, timeline (acute/chronic), emotional representations, illness coherence, consequences, treatment control, and timeline sub-scales, which were investigated at the dimension about attributions concerning the disease, and psychological causal attributions, risk factors, and immunity subscales, which were investigated at the dimension about probable causes, no significant differences were found between groups ( P >0.05). No difference was determined in terms of BDS scores ( z =-0.895, P >0.05). The results of this study demonstrated that IPQ-R could be used reliably in the Turkish PWE. A severe life event such as an earthquake did not change IPQ-R scores in PWE.

  4. Assessment of self-medication among dental students in Pune city, Maharashtra: A cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Dheeraj Deepak Kalra

    2015-01-01

    Full Text Available Introduction: In the recent years, there has been an increasing trend in self-medication with nonprescription (over-the-counter drugs available in pharmacies and retail outlets. There are both advantages and disadvantages of self-medication. Data pertaining to the prevalence of self-medication among dental students in India is scarce. Aim: To determine the level of self-medication among the dental students. Materials and Methods: Descriptive cross-sectional questionnaire study was conducted on 548 dental students from I BDS to IV BDS, interns, and postgraduate students, in classroom setting in census type, hand delivery of questionnaires was done. Out of that, 494 questionnaires were returned duly filled and analyzed. Data analysis were done using SPSS software (v 22.0, IBM. Results: A total of 40.9% of respondents indulged in self-medication. Both male and female dental students equally had a habit of taking medicines on their own. The most common drugs used for self-medication were antipyretics (46.56%, followed by analgesics (40.08%, and cough syrups (18.02%. Cold (19.43% was the major indication for self-medication, followed by (18.02% a cough, and (16.19% was a fever. Most common reason not to see a doctor was that there is no need to see a doctor because of a simple disease (31.58% followed by the need for a quick relief (20.45%. The predominant guiding sources of information for students was media (magazines and internet (38.06% and books (39.88%. Conclusion: The majority of students indulged in the practice of self-medication though they had poor knowledge of the benefits and risks.

  5. Engineered safety in development of liquid poison injection system (shut down system-2) for 500 MWe PHWR

    International Nuclear Information System (INIS)

    Sapra, M.K.; Kundu, S.N.; Mohan, L.R.

    2002-01-01

    Full text: The provision of shut down systems (SDS) is a mandatory requirement for safety of any nuclear reactor. The SDS shall be capable of making and holding the core adequately subcritical in the event of any anticipated operational occurrence and postulated accident conditions. The shut down function will perform as intended when its design and components are thoroughly evaluated for their reliability and effectiveness. A full scale mock up for one injection unit was designed and developed at Hall No.7, BARC. Experimental studies were carried out to qualify the design and evolve process parameters such as gas tank pressure, poison discharge rate and poison injection time. In liquid poison injection system i.e. shutdown system -2, there is no physical barrier, between the two liquids i.e. the poison and the moderator. A liquid in liquid interface, called poison moderator interface (PMI) separates these fluids. Extensive lab scale studies have been carried out on PMI movement study i.e. the interface movement due to molecular diffusion and due to process disturbances under simulated reactor condition. On the basis of lab scale results, a full-scale PMI setup has been designed and developed to generate plant data. From reactor safety consideration, the floating ball in poison tank is designed in such a way that it prevents the over pressurisation of calandria. For this purpose a non-intrusive ultrasonic ball detection system (U-BDS) has been developed. This paper covers the PMI system for 500 MWe PHWR with relevant safety aspects and describes in detail, the experimental results of PMI study. The engineered safety in design, methodology and qualification of U-BDS and its role intended in performance of SDS-2 have been also discussed in the paper

  6. Proposals of counting method for bubble detectors and their intercomparisons

    International Nuclear Information System (INIS)

    Ramalho, Eduardo; Silva, Ademir X.; Bellido, Luis F.; Facure, Alessandro; Pereira, Mario

    2009-01-01

    The study of neutron's spectrometry and dosimetry has become significantly easier due to relatively new devices called bubble detectors. Insensitive to gamma rays and composed by superheated emulsions, they still are subjects of many researches in Radiation Physics and Nuclear Engineering. In bubble detectors, either exposed to more intense neutron fields or for a long time, when more bubbles are produced, the statistical uncertainty during the dosimetric and spectrometric processes is reduced. A proposal of this nature is set up in this work, which presents ways to perform counting processes for bubble detectors and an updated proceeding to get the irradiated detectors' images in order to make the manual counting easier. Twelve BDS detectors were irradiated by RDS111 cyclotron from IEN's (Instituto de Engenharia Nuclear) and photographed using an assembly specially designed for this experiment. Counting was proceeded manually in a first moment; simultaneously, ImagePro was used in order to perform counting automatically. The bubble counting values, either manual or automatic, were compared and the time to get them and their difficult levels as well. After the bubble counting, the detectors' standardizes responses were calculated in both cases, according to BDS's manual and they were also compared. Among the results, the counting on these devices really becomes very hard at a large number of bubbles, besides higher variations in counting of many bubbles. Because of the good agreement between manual counting and the custom program, the last one revealed a good alternative in practical and economical levels. Despite the good results, the custom program needs of more adjustments in order to achieve more accuracy on higher counting on bubble detectors for neutron measurement applications. (author)

  7. Dielectric relaxation studies in super-cooled liquid and glassy phases of anti-cancerous alkaloid: Brucine

    Science.gov (United States)

    Afzal, Aboothahir; Shahin Thayyil, M.; Sulaiman, M. K.; Kulkarni, A. R.

    2018-05-01

    Brucine has good anti-tumor effects, on both liver cancer and breast cancer. It has bioavailability of 40.83%. Since the bioavailability of the drug is low, an alternative method to increase its bioavailability and solubility is by changing the drug into glassy form. We used Differential Scanning Calorimetry (DSC) for studying the glass forming ability of the drug. Brucine was found to be a very good glass former glass transition temperature 365 K. Based on the DSC analysis we have used broadband dielectric spectroscopy (BDS) for studying the drug in the super cooled and glassy state. BDS is an effective tool to probe the molecular dynamics in the super cooled and glassy state. Molecular mobility is found to be present even in the glassy state of this active pharmaceutical ingredient (API) which is responsible for the instability. Our aim is to study the factors responsible for instability of this API in amorphous form. Cooling curves for dielectric permittivity and dielectric loss revealed the presence of structural (α) and secondary relaxations (β and γ). Temperature dependence of relaxation time is fitted by Vogel-Fulcher-Tammann equation and found the values of activation energy of the α relaxation, fragility and glass transition temperature. Paluch's anti correlation is also verified, that the width of the α-loss peak at or near the glass transition temperature Tg is strongly anticorrelated with the polarity of the molecule. The larger the dielectric relaxation strength Δɛ (Tg) of the system, the narrower is the α-loss peak (higher value of βKWW).

  8. Effect of elevated temperature on soil hydrothermal regimes and growth of wheat crop.

    Science.gov (United States)

    Pramanik, P; Chakrabarti, Bidisha; Bhatia, Arti; Singh, S D; Maity, A; Aggarwal, P; Krishnan, P

    2018-03-14

    An attempt has been made to study the effect of elevated temperature on soil hydrothermal regimes and winter wheat growth under simulated warming in temperature gradient tunnel (TGT). Results showed that bulk density (BDs) of 0, 0.9, and 2.5 °C were significantly different whereas BDs of 2.8 and 3.5 °C were not significantly different. Water filled pore space (WFPS) was maximum at 3.5 °C temperature rise and varied between 43.80 and 98.55%. Soil surface temperature (ST) at different dates of sowing increased with rise in sensor temperature and highest ST was observed at S5 sensors (3.5 °C temperature rise). Temperature and its difference were high for the top soil, and were stable for the deep soil. Photosynthesis rate (μmol CO 2 m -2  s -1 ) of wheat was lower at higher temperature in different growth stages of wheat. In wheat, stomatal conductance declined from 0.67 to 0.44 mol m -2  s -1 with temperature rise. Stomatal conductance decreased with increase in soil temperature and gravimetric soil moisture content (SWC). In TGT, 0 °C temperature rise showed highest root weight density (RWD) (5.95 mg cm -3 ); whereas, 2.8 and 3.5 °C showed lowest RWD (4.90 mg cm -3 ). Harvest index was maximum (0.37) with 0 °C temperature rise, and it decreased with increase in temperature, which indicated that both grain and shoot biomass decreased with increase in temperature. Intensive studies are needed to quantify the soil hydrothermal regimes inside TGT along with the crop growth parameters.

  9. Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

    Science.gov (United States)

    Hill, T D M; Cascio, M-G; Romano, B; Duncan, M; Pertwee, R G; Williams, C M; Whalley, B J; Hill, A J

    2013-01-01

    BACKGROUND AND PURPOSE Epilepsy is the most prevalent neurological disease and is characterized by recurrent seizures. Here, we investigate (i) the anticonvulsant profiles of cannabis-derived botanical drug substances (BDSs) rich in cannabidivarin (CBDV) and containing cannabidiol (CBD) in acute in vivo seizure models and (ii) the binding of CBDV BDSs and their components at cannabinoid CB1 receptors. EXPERIMENTAL APPROACH The anticonvulsant profiles of two CBDV BDSs (50–422 mg·kg−1) were evaluated in three animal models of acute seizure. Purified CBDV and CBD were also evaluated in an isobolographic study to evaluate potential pharmacological interactions. CBDV BDS effects on motor function were also investigated using static beam and grip strength assays. Binding of CBDV BDSs to cannabinoid CB1 receptors was evaluated using displacement binding assays. KEY RESULTS CBDV BDSs exerted significant anticonvulsant effects in the pentylenetetrazole (≥100 mg·kg−1) and audiogenic seizure models (≥87 mg·kg−1), and suppressed pilocarpine-induced convulsions (≥100 mg·kg−1). The isobolographic study revealed that the anticonvulsant effects of purified CBDV and CBD were linearly additive when co-administered. Some motor effects of CBDV BDSs were observed on static beam performance; no effects on grip strength were found. The Δ9-tetrahydrocannabinol and Δ9-tetrahydrocannabivarin content of CBDV BDS accounted for its greater affinity for CB1 cannabinoid receptors than purified CBDV. CONCLUSIONS AND IMPLICATIONS CBDV BDSs exerted significant anticonvulsant effects in three models of seizure that were not mediated by the CB1 cannabinoid receptor and were of comparable efficacy with purified CBDV. These findings strongly support the further clinical development of CBDV BDSs for the treatment of epilepsy. PMID:23902406

  10. Electrophysiological Anomalies in Face–Name Memory Encoding in Young Binge Drinkers

    Directory of Open Access Journals (Sweden)

    Rocío Folgueira-Ares

    2017-11-01

    Full Text Available A growing body of evidence indicates that the intake of large amounts of alcohol during one session may have structural and functional effects on the still-maturing brains of young people. These effects are particularly pronounced in prefrontal and hippocampal regions, which appear to be especially sensitive to the neurotoxic effects of alcohol. However, to date, few studies have used the event-related potentials (ERPs technique to analyze the relationship between binge drinking (BD and associative memory. The objective of this study was to examine brain activity during memory encoding using the Subsequent memory paradigm in subjects who have followed a BD pattern of alcohol consumption for at least 2 years. A total of 50 undergraduate students (mean age = 20.6 years, i.e., 25 controls (12 females and 25 binge drinkers (BDs; 11 females, with no personal or family history of alcoholism or psychopathological disorders, performed a visual face–name association memory task. The task used enables assessment of the Difference due to memory effect (Dm, a measure of memory encoding based on comparison of the neural activity associated with subsequent successful and unsuccessful retrieval. In ERP studies, study items that are subsequently remembered elicit larger positive amplitudes at midline parieto-frontal sites than those items that are subsequently forgotten. The Dm effect generally appears in the latency range of about 300–800 ms. The results showed a Dm effect in posterior regions in the 350–650 ms latency range in the Control group. However, in the BD group, no significant differences were observed in the electrophysiological brain activity between remembered and forgotten items during the encoding process. No differences between groups were found in behavioral performance. These findings show that young BDs display abnormal pattern of ERP brain activity during the encoding phase of a visual face–name association task

  11. Multi-GNSS PPP-RTK: From Large- to Small-Scale Networks.

    Science.gov (United States)

    Nadarajah, Nandakumaran; Khodabandeh, Amir; Wang, Kan; Choudhury, Mazher; Teunissen, Peter J G

    2018-04-03

    Precise point positioning (PPP) and its integer ambiguity resolution-enabled variant, PPP-RTK (real-time kinematic), can benefit enormously from the integration of multiple global navigation satellite systems (GNSS). In such a multi-GNSS landscape, the positioning convergence time is expected to be reduced considerably as compared to the one obtained by a single-GNSS setup. It is therefore the goal of the present contribution to provide numerical insights into the role taken by the multi-GNSS integration in delivering fast and high-precision positioning solutions (sub-decimeter and centimeter levels) using PPP-RTK. To that end, we employ the Curtin PPP-RTK platform and process data-sets of GPS, BeiDou Navigation Satellite System (BDS) and Galileo in stand-alone and combined forms. The data-sets are collected by various receiver types, ranging from high-end multi-frequency geodetic receivers to low-cost single-frequency mass-market receivers. The corresponding stations form a large-scale (Australia-wide) network as well as a small-scale network with inter-station distances less than 30 km. In case of the Australia-wide GPS-only ambiguity-float setup, 90% of the horizontal positioning errors (kinematic mode) are shown to become less than five centimeters after 103 min. The stated required time is reduced to 66 min for the corresponding GPS + BDS + Galieo setup. The time is further reduced to 15 min by applying single-receiver ambiguity resolution. The outcomes are supported by the positioning results of the small-scale network.

  12. Dielectric relaxation studies in super-cooled liquid and glassy phases of anti-cancerous alkaloid: Brucine

    Science.gov (United States)

    Afzal, Aboothahir; Shahin Thayyil, M.; Sulaiman, M. K.; Kulkarni, A. R.

    2017-12-01

    Brucine has good anti-tumor effects, on both liver cancer and breast cancer. It has bioavailability of 40.83%. Since the bioavailability of the drug is low, an alternative method to increase its bioavailability and solubility is by changing the drug into glassy form. We used Differential Scanning Calorimetry (DSC) for studying the glass forming ability of the drug. Brucine was found to be a very good glass former glass transition temperature 365 K. Based on the DSC analysis we have used broadband dielectric spectroscopy (BDS) for studying the drug in the super cooled and glassy state. BDS is an effective tool to probe the molecular dynamics in the super cooled and glassy state. Molecular mobility is found to be present even in the glassy state of this active pharmaceutical ingredient (API) which is responsible for the instability. Our aim is to study the factors responsible for instability of this API in amorphous form. Cooling curves for dielectric permittivity and dielectric loss revealed the presence of structural (α) and secondary relaxations (β and γ). Temperature dependence of relaxation time is fitted by Vogel-Fulcher-Tammann equation and found the values of activation energy of the α relaxation, fragility and glass transition temperature. Paluch's anti correlation is also verified, that the width of the α-loss peak at or near the glass transition temperature Tg is strongly anticorrelated with the polarity of the molecule. The larger the dielectric relaxation strength Δɛ (Tg) of the system, the narrower is the α-loss peak (higher value of βKWW).

  13. Data-driven Ontology Development: A Case Study at NASA's Atmospheric Science Data Center

    Science.gov (United States)

    Hertz, J.; Huffer, E.; Kusterer, J.

    2012-12-01

    Well-founded ontologies are key to enabling transformative semantic technologies and accelerating scientific research. One example is semantically enabled search and discovery, making scientific data accessible and more understandable by accurately modeling a complex domain. The ontology creation process remains a challenge for many anxious to pursue semantic technologies. The key may be that the creation process -- whether formal, community-based, automated or semi-automated -- should encompass not only a foundational core and supplemental resources but also a focus on the purpose or mission the ontology is created to support. Are there tools or processes to de-mystify, assess or enhance the resulting ontology? We suggest that comparison and analysis of a domain-focused ontology can be made using text engineering tools for information extraction, tokenizers, named entity transducers and others. The results are analyzed to ensure the ontology reflects the core purpose of the domain's mission and that the ontology integrates and describes the supporting data in the language of the domain - how the science is analyzed and discussed among all users of the data. Commonalities and relationships among domain resources describing the Clouds and Earth's Radiant Energy (CERES) Bi-Directional Scan (BDS) datasets from NASA's Atmospheric Science Data Center are compared. The domain resources include: a formal ontology created for CERES; scientific works such as papers, conference proceedings and notes; information extracted from the datasets (i.e., header metadata); and BDS scientific documentation (Algorithm Theoretical Basis Documents, collection guides, data quality summaries and others). These resources are analyzed using the open source software General Architecture for Text Engineering, a mature framework for computational tasks involving human language.

  14. Suicidal Behaviour in Mood Disorders—Who, When, and Why?

    Science.gov (United States)

    Isometsä, Erkki

    2014-01-01

    Objective: About one-half to two-thirds of all suicides are by people who suffer from mood disorders; preventing suicides among those who suffer from them is thus central for suicide prevention. Understanding factors underlying suicide risk is necessary for rational preventive decisions. Method: The literature on risk factors for completed and attempted suicide among subjects with depressive and bipolar disorders (BDs) was reviewed. Results: Lifetime risk of completed suicide among psychiatric patients with mood disorders is likely between 5% and 6%, with BDs, and possibly somewhat higher risk than patients with major depressive disorder. Longitudinal and psychological autopsy studies indicate suicidal acts usually take place during major depressive episodes (MDEs) or mixed illness episodes. Incidence of suicide attempts is about 20- to 40-fold, compared with euthymia, during these episodes, and duration of these high-risk states is therefore an important determinant of overall risk. Substance use and cluster B personality disorders also markedly increase risk of suicidal acts during mood episodes. Other major risk factors include hopelessness and presence of impulsive–aggressive traits. Both childhood adversity and recent adverse life events are likely to increase risk of suicide attempts, and suicidal acts are predicted by poor perceived social support. Understanding suicidal thinking and decision making is necessary for advancing treatment and prevention. Conclusion: Among subjects with mood disorders, suicidal acts usually occur during MDEs or mixed episodes concurrent with comorbid disorders. Nevertheless, illness factors can only in part explain suicidal behaviour. Illness factors, difficulty controlling impulsive and aggressive responses, plus predisposing early exposures and life situations result in a process of suicidal thinking, planning, and acts. PMID:24881160

  15. Balloon catheter versus basket catheter for endoscopic bile duct stone extraction: a multicenter randomized trial.

    Science.gov (United States)

    Ishiwatari, Hirotoshi; Kawakami, Hiroshi; Hisai, Hiroyuki; Yane, Kei; Onodera, Manabu; Eto, Kazunori; Haba, Shin; Okuda, Toshinori; Ihara, Hideyuki; Kukitsu, Takehiro; Matsumoto, Ryusuke; Kitaoka, Keisuke; Sonoda, Tomoko; Hayashi, Tsuyoshi

    2016-04-01

    Endoscopic bile duct stone (BDS) removal is a well-established treatment; however, the preference for basket or balloon catheters for extraction is operator-dependent. We therefore conducted a multicenter prospective randomized trial to compare catheter performance. We enrolled patients with a BDS diameter ≤ 10 mm and common bile duct diameter ≤ 15 mm. Participants were randomly assigned to groups that were treated with basket or balloon catheters between October 2013 and September 2014. The primary endpoint was the rate of complete clearance of the duct; the secondary endpoints were the rate and time to complete clearance in one endoscopic session. We initially enrolled 172 consecutive patients; 14 were excluded after randomization. The complete clearance rates were 92.3 % (72/78) in the balloon group and 80.0 % (64 /80) in the basket group. The difference in the rates between the two groups was 12.3 percentage points, indicating non-inferiority of the balloon method (non-inferiority limit -10 %; P < 0.001 for non-inferiority). Moreover, the balloon was superior to the basket (P = 0.037). The rate of complete clearance in one endoscopic session was 97.4 % using the balloon and 97.5 % using the basket (P = 1.00). The median times to complete clearance in one endoscopic session were 6.0 minutes (1 - 30) and 7.8 minutes (1 - 37) in the balloon and basket groups, respectively (P = 0.15). For extraction of BDSs ≤ 10 mm, complete endoscopic treatment with a single catheter is more likely when choosing a balloon catheter over a basket catheter.University Hospital Medical Information Network Trials Registry: UMIN000011887. © Georg Thieme Verlag KG Stuttgart · New York.

  16. Fatigue in the mothers of children with cerebral palsy.

    Science.gov (United States)

    Garip, Yesim; Ozel, Sumru; Tuncer, Ozgul Bozkurt; Kilinc, Gizem; Seckin, Feryal; Arasil, Tansu

    2017-04-01

    To evaluate fatigue in the mothers of children with cerebral palsy (CP), and to determine its associations with clinical parameters of CP, depression and quality of life (QoL). Ninety children (50 girls and 40 boys) with spastic CP and their mothers were included. Control group comprised mothers of healthy children. Gross motor function classification system (GMFCS) was used for determining functional status. Spasticity was evaluated by using modified Ashworth scale. Fatigue symptom inventory (FSI) was used for assessing maternal fatigue, Nottingham health profile (NHP) for maternal QoL, and Beck Depression Scale (BDS) for maternal depression. Mothers of children with CP scored significantly higher in all FSI subgroups (intensity of fatigue, duration of fatigue and interference with QoL), all NHP subgroups and BDS (p  0.05). Our findings indicate that fatigue levels of mothers with CP children are higher than those with healthy children and associated with depression and deterioration in QoL in terms of physical, social and emotional functioning. This should be considered while designing a family centred rehabilitation programme for children with CP. Implications for Rehabilitation Caring for a child with cerebral palsy has psychological, social and financial impacts on familiesand is associated with increased levels of fatigue among mothers. The capacity of current programs and services needs to be strengthened to accommodate theneeds of children with CP and their mothers in order to reduce fatigue of mothers. New programs need to be developed to provide psychosocial support for the mothers andto reduce their fatigue as they continue to care for their children. Provision of assistive technology devices (particularly suitable wheelchairs) will be useful inreduction of fatigue levels of mothers.

  17. [Current modalities and concepts on access and use of biospecimen samples and associated data for research from human biobanks].

    Science.gov (United States)

    Siddiqui, Roman; Semler, Sebastian Claudius

    2016-03-01

    It is accepted worldwide that biospecimen and data sharing (BDS) play an essential role for the future of medical research to improve diagnostics and prognostics, e.g. by validated biomarkers. BDS is also pivotal to the development of new therapeutic treatments and for the improvement of population health. Human biobanks can generate an added value to this need by providing biospecimens and/or associated data to researchers. An inspection of several examples of epidemiological as well as clinical/disease-oriented biobanks in Germany shows that best practice procedures (BPP) that are internationally agreed on are being installed for biospecimen and/or data access. In general, fair access is aimed at requiring a written application by the requesting scientist, which is then peer-reviewed for scientific and ethical validity by the Biobank. Applied BPP take into account (i) patient education/agreement according to the informed consent model, (ii) privacy protection, (iii) intellectual property rights, the (iv) notification obligation of health-related findings (including incidental findings), the (v) use of material (MTA) and data transfer agreements (DTA) for mutual legal security, the avoidance of conflicts of interests, as well as for cost recovery/fee for service as a basis for sustainability of the biobank. BPP are rooted in the self-regulation efforts of life sciences and are supported by parent ethics committees in Germany. Central biobank registries displaying aggregated information on biospecimens stored and the research foci constitute an important tool to make biobanks that are scattered across the country visible to each other, and, can thus promote access to hitherto unknown biospecimen and data resources.

  18. Studying of crystal growth and overall crystallization of naproxen from binary mixtures.

    Science.gov (United States)

    Kaminska, E; Madejczyk, O; Tarnacka, M; Jurkiewicz, K; Kaminski, K; Paluch, M

    2017-04-01

    Broadband dielectric spectroscopy (BDS) and differential scanning calorimetry (DSC) were applied to investigate the molecular dynamics and phase transitions in binary mixtures composed of naproxen (NAP) and acetylated saccharides: maltose (acMAL) and sucrose (acSUC). Moreover, the application of BDS method and optical microscopy enabled us to study both crystallization kinetics and crystal growth of naproxen from the solid dispersions with the highest content of modified carbohydrates (1:5wt ratio). It was found that the activation barriers of crystallization estimated from dielectric measurements are completely different for both studied herein mixtures. Much higher E a (=205kJ/mol) was obtained for NAP-acMAL solid dispersion. It is probably due to simultaneous crystallization of both components of the mixture. On the other hand, lower value of E a in the case of NAP-acSUC solid dispersion (81kJ/mol) indicated, that naproxen is the only crystallizing compound. This hypothesis was confirmed by X-ray diffraction studies. We also suggested that specific intermolecular dipole-dipole interactions between active substance and excipient may be an alternative explanation for the difference between activation barrier obtained for NAP-acMAL and NAP-acSUC binary mixtures. Furthermore, optical measurements showed that the activation energy for crystal growth of naproxen increases in binary mixtures. They also revealed that both excipients: acMAL and acSUC move the temperature of the maximum of crystal growth towards lower temperatures. Interestingly, this maximum occurs for nearly the same structural relaxation time, which is a good approximation of viscosity, for all samples. Finally, it was also noticed that although naproxen crystallizes to the same polymorphic form in both systems, there are some differences in morphology of obtained crystals. Thus, the observed behavior may have a significant impact on the bioavailability and dissolution rate of API produced in that way

  19. Quasielastic neutron scattering study of hydrogen motions in an aqueous poly(vinyl methyl ether) solution.

    Science.gov (United States)

    Capponi, S; Arbe, A; Cerveny, S; Busselez, R; Frick, B; Embs, J P; Colmenero, J

    2011-05-28

    We present a quasielastic neutron scattering (QENS) investigation of the component dynamics in an aqueous Poly(vinyl methyl ether) (PVME) solution (30% water content in weight). In the glassy state, an important shift in the Boson peak of PVME is found upon hydration. At higher temperatures, the diffusive-like motions of the components take place with very different characteristic times, revealing a strong dynamic asymmetry that increases with decreasing T. For both components, we observe stretching of the scattering functions with respect to those in the bulk and non-Gaussian behavior in the whole momentum transfer range investigated. To explain these observations we invoke a distribution of mobilities for both components, probably originated from structural heterogeneities. The diffusive-like motion of PVME in solution takes place faster and apparently in a more continuous way than in bulk. We find that the T-dependence of the characteristic relaxation time of water changes at T ≲ 225 K, near the temperature where a crossover from a low temperature Arrhenius to a high temperature cooperative behavior has been observed by broadband dielectric spectroscopy (BDS) [S. Cerveny, J. Colmenero and A. Alegría, Macromolecules, 38, 7056 (2005)]. This observation might be a signature of the onset of confined dynamics of water due to the freezing of the PVME dynamics, that has been selectively followed by these QENS experiments. On the other hand, revisiting the BDS results on this system we could identify an additional "fast" process that can be attributed to water motions coupled with PVME local relaxations that could strongly affect the QENS results. Both kinds of interpretations, confinement effects due to the increasing dynamic asymmetry and influence of localized motions, could provide alternative scenarios to the invoked "strong-to-fragile" transition. © 2011 American Institute of Physics

  20. Effect of Oral Tissue Fluids on Compressive Strength of MTA and Biodentine: An In vitro Study.

    Science.gov (United States)

    Subramanyam, Divya; Vasantharajan, Madhusudhan

    2017-04-01

    Over the past many years various root end filling materials have been used which have been tested for their physical properties but each of them had certain limitations. In clinical practice, root end filling materials are exposed to oral tissue fluids which may compromise their longevity. The aim of this study was to investigate the effects of oral tissue fluids on compressive strength of Mineral Trioxide Aggregate (MTA) and biodentine. MTA and biodentine cylinders measuring 6 mm × 4 mm were prepared using acrylic blocks. They were divided into six groups; (Group 1) (MTA) (n=3), (Group 2) MTA contaminated with saliva, (MTA-S) (n=3), Group 3: MTA contaminated with blood, MTA-B (n=3), Group 4: Biodentine (BD), Group 5: Biodentine contaminated with saliva (BD-S) (n=5), Group 6: Biodentine contaminated with blood (BD-B) (n=5). The mould was contaminated with saliva and blood and incubated at 37°C at 100% humidity for three days and compressive strength (MPa) was measured using universal testing machine and the data was analyzed statistically using one-way ANOVA test. There was no significant difference in the compressive strength between the three groups i.e., MTA, MTA-S, MTA-B (p > 0.05). However, there was higher compressive strength in the MTA-B group when compared to MTA and MTA-S. Also, there was no statistical significant difference between BD, BD-S, BD-B (p>0.05). This study showed that the compressive strength of MTA and biodentine was not adversely affected by contamination with oral tissue fluids like blood and saliva.

  1. Creating smiles amidst stress: A questionnaire based study

    Directory of Open Access Journals (Sweden)

    Vivek Sunil Nair

    2015-01-01

    Full Text Available Introduction: Dentistry is considered as a stressful field in the medical profession. The study was conducted to determine the different problems faced by dental students, and the effect of these stressors on their lives. Materials and Methods: A modified dental environmental stress (D.E.S questionnaire was administered to students of 1st year B.D.S to final year B.D.S and Interns. The questionnaire had 35 questions divided into five categories: Demographic data, living/accommodation stressors, personal stressors, academic stressors, and clinical stressors. Statistical significance between the mean D.E.S scores of gender and years of study was compared using t-test and one-way ANOVA. Results: A total of 292 students completed and returned the questionnaire with a response rate of 74.8%. The overall mean D.E.S score of females was higher (2.37 ± 0.44 when compared to males (2.23 ± 0.45. The overall D.E.S scores differed among the students of different academic years with the 2nd year students being more stressed (2.45 ± 0.52 as compared to the students of other academic years. Discussion: Understanding the various causes of stress in students is very much necessary to set up a curriculum that is student - friendly and at the same time, effective enough. Conclusion: Clinical and academic work causing increased amount of stress can be brought down by the student, if he/she simplifies their schedule, practices breathing exercises, performs yoga, etc.

  2. Beliefs and barriers for organ donation and influence of educational intervention on dental students: A questionnaire study

    Directory of Open Access Journals (Sweden)

    Basavaraj Patthi

    2015-01-01

    Full Text Available Introduction: Many developmental disorders or accidents leave the victims crippled resulting in vision loss and fatal damages to the vital organs. At such point of time, organ donation remains the only ray of hope. However, there exists very little awareness among the masses regarding the same. Aim: To assess the knowledge, attitude and, belief on/toward organ donation and the impact of an educational intervention among the Dental undergraduate students of a Dental College of Modinagar, India. Materials and Methods: A questionnaire and intervention based survey was carried out. All the students from B.D.S 1 st year to internship and patients who attended screening/treatment camps organized by the Department of Public Health Dentistry were included for the study. A 11-item structured questionnaire to assess the knowledge, attitude, and beliefs regarding organ donation was used. This was followed by an educational intervention for the college students. Immediately after this session, the same questionnaire was again distributed and collected. Chi-square test was used to analyze the statistical difference. Results: The overall level of knowledge and beliefs about the concept of organ donation in the two groups was similar before the intervention was provided. After the intervention for B.D.S students, a significant improvement in the level of knowledge and attitude was observed. About 74.6% of students in contrast to 42.3% of the patients realized the significance of organ (P < 0.0001 and 72.4% of the patients and 63.4% of students considered organ donation against their religious beliefs. About 65.6% of the students post interventions were willing to educate the masses about significance of organ donation. Conclusion: A significant knowledge gap exists amongst the dental undergraduates and the general population for organ donation. The positive influence of educational intervention emphasizes the need of an intervention to bring positive changes

  3. Glass transition of partially crystallized gelatin-water mixtures studied by broadband dielectric spectroscopy

    Science.gov (United States)

    Sasaki, Kaito; Kita, Rio; Shinyashiki, Naoki; Yagihara, Shin

    2014-03-01

    The glass transition of partially crystallized gelatin-water mixtures was investigated for gelatin concentrations of 40 and 20 wt. % by broadband dielectric spectroscopy (BDS) in wide frequency (10 mHz-50 GHz) and temperature (113-298 K) ranges. Three dielectric relaxation processes were clearly observed. The origin of each relaxation process was the same as that observed for partially crystallized bovine serum albumin (BSA)-water mixtures [N. Shinyashiki et al., J. Phys. Chem. B 113, 14448 (2009)]. The relaxation process at the highest frequency is originated from uncrystallized water (UCW) in the hydration shell of gelatin. Its relaxation time is almost the same as that of water in uncrystallized system; water in various binary aqueous mixtures and confined water in nanoscale region. The relaxation process at the intermediate frequency is originated from ice, and its relaxation time and strength were similar to those for the relaxation of pure ice, particularly above 240 K. The glass transition temperature Tg, is defined by BDS measurement as the temperature at which dielectric relaxation time τ, is 100-1000 s. The relaxation process at the lowest frequency, Tg is approximately 200 K, is originated from the cooperative motion of water and gelatin. This relaxation is strong and has a similar relaxation strength to that of hydrated BSA. At Tg for the relaxation process involving the cooperative motion of gelatin and water, the temperature dependence of the relaxation process of UCW crosses over from Vogel-Fulcher behavior to Arrhenius behavior with decreasing temperature. A characteristic property of the gelatin-water mixture is a change in the temperature dependence of the relaxation time of the relaxation processes of hydrated gelatin at approximately 260 K.

  4. Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.

    Science.gov (United States)

    Hill, T D M; Cascio, M-G; Romano, B; Duncan, M; Pertwee, R G; Williams, C M; Whalley, B J; Hill, A J

    2013-10-01

    Epilepsy is the most prevalent neurological disease and is characterized by recurrent seizures. Here, we investigate (i) the anticonvulsant profiles of cannabis-derived botanical drug substances (BDSs) rich in cannabidivarin (CBDV) and containing cannabidiol (CBD) in acute in vivo seizure models and (ii) the binding of CBDV BDSs and their components at cannabinoid CB1 receptors. The anticonvulsant profiles of two CBDV BDSs (50-422 mg·kg(-1) ) were evaluated in three animal models of acute seizure. Purified CBDV and CBD were also evaluated in an isobolographic study to evaluate potential pharmacological interactions. CBDV BDS effects on motor function were also investigated using static beam and grip strength assays. Binding of CBDV BDSs to cannabinoid CB1 receptors was evaluated using displacement binding assays. CBDV BDSs exerted significant anticonvulsant effects in the pentylenetetrazole (≥100 mg·kg(-1) ) and audiogenic seizure models (≥87 mg·kg(-1) ), and suppressed pilocarpine-induced convulsions (≥100 mg·kg(-1) ). The isobolographic study revealed that the anticonvulsant effects of purified CBDV and CBD were linearly additive when co-administered. Some motor effects of CBDV BDSs were observed on static beam performance; no effects on grip strength were found. The Δ(9) -tetrahydrocannabinol and Δ(9) -tetrahydrocannabivarin content of CBDV BDS accounted for its greater affinity for CB1 cannabinoid receptors than purified CBDV. CBDV BDSs exerted significant anticonvulsant effects in three models of seizure that were not mediated by the CB1 cannabinoid receptor and were of comparable efficacy with purified CBDV. These findings strongly support the further clinical development of CBDV BDSs for the treatment of epilepsy. © 2013 The British Pharmacological Society.

  5. THE LONG-TERM DYNAMICAL EVOLUTION OF DISK-FRAGMENTED MULTIPLE SYSTEMS IN THE SOLAR NEIGHBORHOOD

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yun [Department of Astronomy, School of Physics, Peking University, Yiheyuan Lu 5, Haidian Qu, Beijing 100871 (China); Kouwenhoven, M. B. N. [Department of Mathematical Sciences, Xi’an Jiaotong-Liverpool University, 111 Ren’ai Road, Suzhou Dushu Lake Science and Education Innovation District, Suzhou Industrial Park, Suzhou 215123 (China); Stamatellos, D. [Jeremiah Horrocks Institute for Mathematics, Physics and Astronomy, University of Central Lancashire, Preston PR1 2HE (United Kingdom); Goodwin, Simon P., E-mail: t.kouwenhoven@xjtlu.edu.cn [Department of Physics and Astronomy, The University of Sheffield, Hicks Building, Hounsfield Road, Sheffield S3 7RH (United Kingdom)

    2016-11-10

    The origin of very low-mass hydrogen-burning stars, brown dwarfs (BDs), and planetary-mass objects (PMOs) at the low-mass end of the initial mass function is not yet fully understood. Gravitational fragmentation of circumstellar disks provides a possible mechanism for the formation of such low-mass objects. The kinematic and binary properties of very low-mass objects formed through disk fragmentation at early times (<10 Myr) were discussed in our previous paper. In this paper we extend the analysis by following the long-term evolution of disk-fragmented systems up to an age of 10 Gyr, covering the ages of the stellar and substellar populations in the Galactic field. We find that the systems continue to decay, although the rates at which companions escape or collide with each other are substantially lower than during the first 10 Myr, and that dynamical evolution is limited beyond 1 Gyr. By t = 10 Gyr, about one third of the host stars are single, and more than half have only one companion left. Most of the other systems have two companions left that orbit their host star in widely separated orbits. A small fraction of companions have formed binaries that orbit the host star in a hierarchical triple configuration. The majority of such double-companion systems have internal orbits that are retrograde with respect to their orbits around their host stars. Our simulations allow a comparison between the predicted outcomes of disk fragmentation with the observed low-mass hydrogen-burning stars, BDs, and PMOs in the solar neighborhood. Imaging and radial velocity surveys for faint binary companions among nearby stars are necessary for verification or rejection of the formation mechanism proposed in this paper.

  6. Effect of Oral Tissue Fluids on Compressive Strength of MTA and Biodentine: An In vitro Study

    Science.gov (United States)

    Vasantharajan, Madhusudhan

    2017-01-01

    Introduction Over the past many years various root end filling materials have been used which have been tested for their physical properties but each of them had certain limitations. In clinical practice, root end filling materials are exposed to oral tissue fluids which may compromise their longevity. Aim The aim of this study was to investigate the effects of oral tissue fluids on compressive strength of Mineral Trioxide Aggregate (MTA) and biodentine. Materials and Methods MTA and biodentine cylinders measuring 6 mm × 4 mm were prepared using acrylic blocks. They were divided into six groups; (Group 1) (MTA) (n=3), (Group 2) MTA contaminated with saliva, (MTA-S) (n=3), Group 3: MTA contaminated with blood, MTA-B (n=3), Group 4: Biodentine (BD), Group 5: Biodentine contaminated with saliva (BD-S) (n=5), Group 6: Biodentine contaminated with blood (BD-B) (n=5). The mould was contaminated with saliva and blood and incubated at 37°C at 100% humidity for three days and compressive strength (MPa) was measured using universal testing machine and the data was analyzed statistically using one-way ANOVA test. Results There was no significant difference in the compressive strength between the three groups i.e., MTA, MTA-S, MTA-B (p > 0.05). However, there was higher compressive strength in the MTA-B group when compared to MTA and MTA-S. Also, there was no statistical significant difference between BD, BD-S, BD-B (p>0.05). Conclusion This study showed that the compressive strength of MTA and biodentine was not adversely affected by contamination with oral tissue fluids like blood and saliva. PMID:28571272

  7. Preparation and dielectric properties of BaCu(B2O5)-doped SrTiO3-based ceramics for energy storage

    International Nuclear Information System (INIS)

    Li, Lingxia; Yu, Xiaoxu; Cai, Haocheng; Liao, Qingwei; Han, Yemei; Gao, Zhengdong

    2013-01-01

    Highlights: • BaCu(B 2 O 5 ) is added to the multi-ions doped SrTiO 3 ceramics as sintering aid. • The sintering temperature is decreased from 1300 °C to 1075 °C. • The incorporation of Ba 2+ into the matrix increases the dielectric constant. • The breakdown strength increases due to the decrease of grain size and porosity. • The dissolution of BCB contributes to the improvement of dielectric properties. -- Abstract: BaCu(B 2 O 5 ) (BCB) was used as sintering aids to lower the sintering temperature of multi-ions doped SrTiO 3 ceramics effectively from 1300 °C to 1075 °C by conventional solid state method. The effect of BCB content on crystalline structures, microstructures and properties of the ceramics was investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and dielectric measurements, respectively. The addition of BCB enhanced the breakdown strength (BDS) while did not sacrifice the dielectric constant. The enhancement of BDS should be due to the modification of microstructures, i.e., smaller and more homogeneous grain sizes after BCB addition. The dielectric constant of BCB-doped ceramics maintained a stable value with 1.0 mol% BCB, which was dominated by the combination of two opposite effects caused by the presence of second phases and the incorporation of Cu 2+ and Ba 2+ , while further increase was owing to the increase of dissolved Ba 2+ ions when the content of BCB is more than 2.0 mol%. The multi-ions doped SrTiO 3 ceramics with 1.0 mol% BCB addition showed optimal dielectric properties as follows: dielectric constant of 311.37, average breakdown strength of 28.78 kV/mm, discharged energy density of 1.05 J/cm 3 and energy efficiency of 98.83%

  8. Deformation effects on sub-barrier fusion cross sections in 16O+174,176Yb

    Science.gov (United States)

    Rajbongshi, Tapan; Kalita, K.; Nath, S.; Gehlot, J.; Banerjee, Tathagata; Mukul, Ish; Dubey, R.; Madhavan, N.; Lin, C. J.; Shamlath, A.; Laveen, P. V.; Shareef, M.; Kumar, Neeraj; Jisha, P.; Sharma, P.

    2016-05-01

    Background: Couplings with various reaction channels are known to enhance sub-barrier fusion cross sections by several orders in magnitude. However, a few open questions still remain. For example, the influence of higher order static deformations on sub-barrier fusion cross sections is yet to be comprehensively understood. Purpose: We study the role of hexadecapole nuclear deformation effect on sub-barrier fusion cross sections. Also, this work aims to extract hexadecapole deformation (β4) in nuclei in the lanthanide region. Method: The evaporation residue (ER) excitation functions for 16O+174,176Yb were measured at laboratory beam energies (Elab) in the range of 64.6-103.6 MeV. Measurements were carried out by employing the recoil mass spectrometer Heavy Ion Reaction Analyzer (HIRA) at IUAC, New Delhi. Fusion barrier distributions (BDs) were extracted from data. Results from the experiment were subjected to coupled-channels analysis, in which β4 was varied as a free parameter. Results: Experimental fusion cross sections at energies below the barrier expectedly showed strong enhancement compared to the predictions from the one-dimensional barrier penetration model. Data were satisfactorily reproduced after inclusion of negative β4 for both the targets in the coupled-channels calculation. Conclusions: The significant role of hexadecapole deformation was observed in the sub-barrier fusion of 16O+174,176Yb. The proposed value of β4 reproduced the measured fusion excitation function reasonably well. The BDs from these data were also extracted but no definitive conclusions could be drawn from them.

  9. Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells.

    Directory of Open Access Journals (Sweden)

    Zhi-Hui Zhang

    Full Text Available Previous studies demonstrated that inflammatory microenvironment promoted prostate cancer progression. This study investigated whether total glucosides of paeony (TGP, the active constituents extracted from the root of Paeonia Lactiflora Pall, suppressed lipopolysaccharide (LPS-stimulated proliferation, migration and invasion in androgen insensitive prostate cancer cells. PC-3 cells were incubated with LPS (2.0 μg/mL in the absence or presence of TGP (312.5 μg /mL. As expected, cells at S phase and nuclear CyclinD1, the markers of cell proliferation, were increased in LPS-stimulated PC-3 cells. Migration activity, as determined by wound-healing assay and transwell migration assay, and invasion activity, as determined by transwell invasion assay, were elevated in LPS-stimulated PC-3 cells. Interestingly, TGP suppressed LPS-stimulated PC-3 cells proliferation. Moreover, TGP inhibited LPS-stimulated migration and invasion of PC-3 cells. Additional experiment showed that TGP inhibited activation of nuclear factor kappa B (NF-κB and mitogen-activated protein kinase (MAPK/p38 in LPS-stimulated PC-3 cells. Correspondingly, TGP attenuated upregulation of interleukin (IL-6 and IL-8 in LPS-stimulated PC-3 cells. In addition, TGP inhibited nuclear translocation of signal transducer and activator of transcription 3 (STAT3 in LPS-stimulated PC-3 cells. These results suggest that TGP inhibits inflammation-associated STAT3 activation and proliferation, migration and invasion in androgen insensitive prostate cancer cells.

  10. Antidepressant-like effect of peony glycosides in mice.

    Science.gov (United States)

    Mao, Qing-Qiu; Ip, Siu-Po; Tsai, Sam-Hip; Che, Chun-Tao

    2008-09-26

    The root part of Paeonia lactiflora Pall. (Ranunculaceae), known as peony, is often used in Chinese herbal formulae for the treatment of depression-like disorders. Previous studies in our laboratory have shown that an ethanol extract of peony produced antidepressive effects in mouse models of depression. It is well known that peony contains glycosides such as paeoniflorin and albiflorin, yet it remains unclear whether the total glycosides of peony (TGP) are effective. The present study aims to evaluate the antidepressant-like effects of TGP. The antidepressant-like effects of TGP was determined by using animal models of depression including forced swim and tail suspension tests. The acting mechanism was explored by determining the effect of TGP on the activities of monoamine oxidases. Intragastric administration of TGP at 80 and 160 mg/kg for seven days caused a significant reduction of immobility time in both forced swim and tail suspension tests, yet TGP did not stimulate locomotor activity in the open-field test. In addition, TGP treatment antagonized reserpine-induced ptosis and inhibited the activities of monoamine oxidases in mouse cerebrum. These results suggest that the antidepressive effects of TGP are mediated, at least in part, by the inhibition of monoamine oxidases.

  11. Effects of total glucosides of paeony on oxidative stress in the kidney from diabetic rats.

    Science.gov (United States)

    Su, Jing; Zhang, Pei; Zhang, Jing-Jing; Qi, Xiang-Ming; Wu, Yong-Gui; Shen, Ji-Jia

    2010-03-01

    TGP, extracted from the traditional Chinese herb root of Paeonia lactiflora pall, has been shown to have therapeutic effect in experimental diabetic nephropathy. However, its mechanism is not fully understood. In this study, the effects of TGP on oxidative stress were investigated in the kidney of diabetic rats induced by streptozotocin. TGP (50, 100, 200mg/kg) was orally administered once a day for 8 weeks. TGP treatment in all three doses significantly lowered 24 h urinary albumin excretion rate in diabetic rats and attenuated glomerular volume. TGP treatment with 100 and 200mg/kg significantly reduced indices for tubulointerstitial injury in diabetic rats. The level of MDA was significantly increased in the kidney of diabetic rats and attenuated by TGP treatment at the dose of 200mg/kg. TGP treatment in a dose-dependent manner decreased the level of 3-NT protein of the kidney which increased under diabetes. T-AOC was significantly reduced in diabetic rat kidney and remarkably increased by TGP treatment at the dose of 100 and 200mg/kg. Activity of antioxidant enzyme such as SOD, CAT was markedly elevated by TGP treatment with 200mg/kg. Western blot analysis showed that p-p38 MAPK and NF-kappaB p65 protein expression increased in diabetic rat kidney, which were significantly decreased by TGP treatment. It seems likely that oxidative stress is increased in the diabetic rat kidneys, while TGP can prevent diabetes-associated renal damage against oxidative stress.

  12. Renoprotective effect of total glucosides of paeony (TGP) and its mechanism in experimental diabetes.

    Science.gov (United States)

    Wu, Yonggui; Ren, Kejun; Liang, Chao; Yuan, Liang; Qi, Xiangming; Dong, Jing; Shen, Jijia; Lin, Shanyan

    2009-01-01

    Total glucosides of paeony (TGP), extracted from the root of Paeonia lactiflora pall, has been shown to have ant-inflammatory and antioxidative actions. The aims of this study were to elucidate the renoprotective effect of TGP and its mechanism in experimental diabetes. Streptozotocin-induced diabetic rats were treated with TGP for 8 weeks. Treatment with TGP at 50, 100, and 200 mg/kg significantly lowered 24-h urinary albumin excretion rate in diabetic rats. TGP treatment in all doses markedly attenuated glomerular volume, and treatment with TGP at 100 and 200 mg/kg markedly reduced indices for tubulointerstitial injury in diabetic rats. Western blot analysis showed that the expressions of 1 alpha (IV) collagen, intercellular adhesion molecule (ICAM)-1, interleukin (IL)-1, tumor necrosis factor (TNF)-alpha, NF-kappaB p65, and 3-nitrotyrosine (3-NT) protein were increased in the kidneys of diabetic rats; the increases in these proteins were all dose-dependently and significantly inhibited by TGP treatment. The expression of nephrin protein was significantly reduced in the kidneys from diabetic rats and markedly increased by TGP treatment. The expression of transforming growth factor (TGF)-beta1 protein in the kidney was also significantly increased in diabetic rats, which was significantly inhibited by treatment with TGP at all doses. Our data suggest that TGP treatment ameliorates early renal injury via the inhibition of expression of ICAM-1, IL-1, TNF-alpha, and 3-NT in the kidneys of diabetic rats.

  13. The response of dark septate endophytes (DSE) to heavy metals in pure culture.

    Science.gov (United States)

    Ban, Yihui; Tang, Ming; Chen, Hui; Xu, Zhouying; Zhang, Haihan; Yang, Yurong

    2012-01-01

    Dark septate endophytes (DSE) occur widely in association with plants exposed to heavy metal stress. However, little is known about the response of DSE exposed to heavy metals. In this study, five DSE were isolated from the roots of Astragalus adsurgens Pall. seedlings growing on lead-zinc mine tailings in China. Based on morphological characteristics and DNA sequence analyses, the isolates were identified as Gaeumannomyces cylindrosporus, Paraphoma chrysanthemicola, Phialophora mustea, Exophiala salmonis, and Cladosporium cladosporioides. G. cylindrosporus was selected to explore responses to Pb stress. Scanning electron microscopic observations of G. cylindrosporus grown on solid medium revealed curling of hyphae and formation of hyphal coils in response to Pb. In contrast, in liquid medium, hyphae became thick and swollen with an increase in Pb (II) concentration. We interpret that these changes are related to the variation in cell wall components. We also demonstrated that fungal melanin content increased with the addition of Pb(II). Melanin, as an important component in the cell wall, is known to be an essential antioxidant responsible for decreasing heavy metal toxicity. We also measured the total soluble protein content and glutathione (GSH) concentrations in G. cylindrosporus and found that they initially increased and then decreased with the increase of Pb(II) concentrations. The antioxidant enzyme activities were also examined, and the results showed that superoxide dismutase (SOD) activity was significantly positively correlated with Pb(II) concentrations (r = 0.957, Pheavy metals.

  14. Plant uptake and transport of 241Am

    International Nuclear Information System (INIS)

    Wallace, A.; Romney, E.M.; Mueller, R.T. Sr.; soufi, S.M.

    1981-01-01

    We conducted several experiments with 241 Am to obtain a more complete understanding of how this transuranium element is absorbed and transported in plants. In a plant species (Tamarix pentandra Pall.) that has salt glands in the leaves excreting NaCl and other ions, 241 Am was not pumped through these glands. Cyanide, which forms complexes with any metals, when applied to a calcareous soil, greatly increased the transport of 241 Am into stems and leaves of bush bean plants. Radioactive cyanide ( 14 C) was also transported to leaves and stems. When radish was grown in both calcareous and noncalcareous soils, 241 Am appeared to be fixed on the peel so firmly that it was resistant to removal by HNO 3 washing. The chelating agent DTPA induced increased transport of 241 Am to leaves and into the fleshy roots of the radish. Data for Golden Cross hybrid corn grown in solution culture showed at least seven times as much 241 Am transport to the xylem exudatields are corrected by recovery of added tracers

  15. Validation of a real-time PCR based method for detection of Clostridium botulinum types C, D and their mosaic variants C-D and D-C in a multicenter collaborative trial.

    Science.gov (United States)

    Woudstra, Cedric; Skarin, Hanna; Anniballi, Fabrizio; Auricchio, Bruna; De Medici, Dario; Bano, Luca; Drigo, Ilenia; Hansen, Trine; Löfström, Charlotta; Hamidjaja, Raditijo; van Rotterdam, Bart J; Koene, Miriam; Bäyon-Auboyer, Marie-Hélène; Buffereau, Jean-Philippe; Fach, Patrick

    2013-08-01

    Two real-time PCR arrays based on the GeneDisc(®) cycler platform (Pall-GeneDisc Technologies) were evaluated in a multicenter collaborative trial for their capacity to specifically detect and discriminate Clostridium botulinum types C, D and their mosaic variants C-D and D-C that are associated with avian and mammalian botulism. The GeneDisc(®) arrays developed as part of the DG Home funded European project 'AnibioThreat' were highly sensitive and specific when tested on pure isolates and naturally contaminated samples (mostly clinical specimen from avian origin). Results of the multicenter collaborative trial involving eight laboratories in five European Countries (two laboratories in France, Italy and The Netherlands, one laboratory in Denmark and Sweden), using DNA extracts issued from 33 pure isolates and 48 naturally contaminated samples associated with animal botulism cases, demonstrated the robustness of these tests. Results showed a concordance among the eight laboratories of 99.4%-100% for both arrays. The reproducibility of the tests was high with a relative standard deviation ranging from 1.1% to 7.1%. Considering the high level of agreement achieved between the laboratories these PCR arrays constitute robust and suitable tools for rapid detection of C. botulinum types C, D and mosaic types C-D and D-C. These are the first tests for C. botulinum C and D that have been evaluated in a European multicenter collaborative trial. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. FIRST REPORT OF 'CANDIDATUS PHYTOPLASMA ULMI' IN ULMUS LAEVIS IN GERMANY.

    Science.gov (United States)

    Eisold, A M; Kube, M; Holz, S; Büttner, C

    2015-01-01

    The wall-less bacteria of the provisory taxon 'Candidatus Phytoplasma' are obligate parasites and associated to diseases in many important crops and trees worldwide. 'Ca. Phytoplasma ulmi', assigned to 16SrV-A subgroup, is a quarantine pest and described to be associated to elm phloem necrosis, leaf yellowing, stunting, witches broom and decline in various elm species. Elm yellows phytoplasmas (EY) have been reported in several European countries but not in Ulmus laevis in Germany so far. Leaf samples from European white elms (Ulmus leavis PALL.) with and without chlorotic symptoms were investigated for EYs infection in Berlin and Brandenburg, Germany, through performing diagnostic nested PCR targeting partial rRNA operon of phytoplasmas. Specific PCR-products were obtained from 30 out of 59 samples. Partial 16S-rDNA sequences were assigned to 'Ca. P. ulmi' through sequence analysis, while sequence variation was observed. This is the first report of U. laevis infected with 'Ca. P. ulmi' in Germany.

  17. Stabilization of Fast Pyrolysis Oil: Post Processing Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Douglas C.; Lee, Suh-Jane; Hart, Todd R.

    2012-03-01

    UOP LLC, a Honeywell Company, assembled a comprehensive team for a two-year project to demonstrate innovative methods for the stabilization of pyrolysis oil in accordance with DOE Funding Opportunity Announcement (FOA) DE-PS36-08GO98018, Biomass Fast Pyrolysis Oil (Bio-oil) Stabilization. In collaboration with NREL, PNNL, the USDA Agricultural Research Service (ARS), Pall Fuels and Chemicals, and Ensyn Corporation, UOP developed solutions to the key technical challenges outlined in the FOA. The UOP team proposed a multi-track technical approach for pyrolysis oil stabilization. Conceptually, methods for pyrolysis oil stabilization can be employed during one or both of two stages: (1) during the pyrolysis process (In Process); or (2) after condensation of the resulting vapor (Post-Process). Stabilization methods fall into two distinct classes: those that modify the chemical composition of the pyrolysis oil, making it less reactive; and those that remove destabilizing components from the pyrolysis oil. During the project, the team investigated methods from both classes that were suitable for application in each stage of the pyrolysis process. The post processing stabilization effort performed at PNNL is described in this report. The effort reported here was performed under a CRADA between PNNL and UOP, which was effective on March 13, 2009, for 2 years and was subsequently modified March 8, 2011, to extend the term to December 31, 2011.

  18. Cytomegalovirus infectivity in whole blood following leukocyte reduction by filtration.

    Science.gov (United States)

    Lipson, S M; Shepp, D H; Match, M E; Axelrod, F B; Whitbread, J A

    2001-07-01

    Cytomegalovirus (CMV) may be transmitted by transfusion of whole blood and cellular components processed according to standard processing procedures. A need exists to develop new procedures to remove CMV and other leukocyte-borne viruses from donor blood. Ten patients (AIDS/bone marrow transplants) who were CMV antigenemic (virus subsequently confirmed by isolation), donated 50 mL of venous blood within 24 to 72 hours of the initial antigen detection. Twenty-five-milliliter aliquots of each specimen were passed through Purecell Neo Neonatal Leukocyte Reduction Filters (Pall, East Hills, NY). The remaining 25-mL nonfiltered aliquots, as well as the blood filtrates, were subjected to infectivity endpoint determinations. The Purecell Neo filter effected a 3 to 4 log10 leukocyte reduction. CMV input titers ranged from less than 10 to 7.3 x 10(1) median tissue culture infectious dose (TCID50) per milliliter. CMV was not isolated from any postfiltration effluent (i.e., leukocytes, erythrocytes, or plasma). CMV DNA was not detected by nested polymerase chain reaction in 8 of 10 postfiltrate blood specimens. The Purecell Neo filter was efficacious in eliminating or significantly reducing viral (CMV) load in venous blood.

  19. Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant Paeonia lactiflora

    Directory of Open Access Journals (Sweden)

    Jin-Yuan Ho

    2014-04-01

    Full Text Available Bai Shao (BS, the root of Paeonia lactiflora Pall., a common Chinese herb in many recipes used to treat viral infection and liver diseases, is recognized for its ability to nourish menstruation, its Yin convergence, and as an antiperspirant. However, the mechanism and components for its antiviral function remain to be elucidated. In this study, an ethanolic extract of BS was further partitioned into aqueous and organic parts (EAex for in vitro functional study and in vivo efficacy testing. EAex exhibited an IC50 of 0.016 ± 0.005 mg/mL against influenza virus A/WSN/33 (H1N1, with broad-spectrum inhibitory activity against different strains of human influenza A viruses, including clinical oseltamivir-resistant isolates and an H1N1pdm strain. The synthesis of both viral RNA and protein was profoundly inhibited when the cells were treated with EAex. A time-of-addition assay demonstrated that EAex exerted its antiviral activity at various stages of the virus replication cycle. We addressed its antiviral activity at virus entry and demonstrated that EAex inhibits viral hemagglutination and viral binding to and penetration into host cells. In vivo animal testing showed that 200 mg/kg/d of EAex offered significant protection against viral infection. We conclude that BS possesses antiviral activity and has the potential for development as an anti-influenza agent.

  20. Efficacy of Rodent Control in Alfalfa and Wheat Crops Using Chemical and Natural Rodenticides

    Directory of Open Access Journals (Sweden)

    Suzana Đedović

    2007-01-01

    Full Text Available Biological efficacy of chemical and natural rodenticides in controlling rodents in alfalfa and wheat crops was investigated. The experiment was set up using a randomized block design with four replicates and 400 m2 plots in compliace with a standard OEPP/EPPO method. Examination was based on the average number of active holes and rodenticide efficacy was measured three, seven, 14 and 28 days after treatment. Rodent numbers were computed from the number of active holes, and rodenticide efficacy using Abbott’s formula.The appearance and arrangement of active holes indicated the presence of common vole (Microtus arvalis Pall and striped field mouse (Apodemus agrarius in the plots. The products tested demonstrated satisfactory efficacy in controlling rodents in alfalfa and wheatcrops. Products based on vitamin D3 achieved 87-90% efficacy in both crops. The efficacy of a bromadiolone-based product ranged from 84% to 90%, while a cellulose product displayed the highest variation in efficacy, ranging from 86% to 98%.

  1. Harvest season, high polluted season in East China

    International Nuclear Information System (INIS)

    Huang Xin; Song Yu; Li Mengmeng; Li Jianfeng; Zhu Tong

    2012-01-01

    East China, a major agricultural zone with a dense population, suffers from severe air pollution during June, the agricultural harvest season, every year. Crop burning emits tremendous amounts of combustion products into the atmosphere, not only rapidly degrading the local air quality but also affecting the tropospheric chemistry, threatening public health and affecting climate change. Recently, in mid-June 2012, crop fires left a thick pall of haze over East China. We evaluated the PM 10 , PM 2.5 (particulates less than 10 and 2.5 μm in aerodynamic diameter) and BC (black carbon) emissions by analyzing detailed census data and moderate resolution imaging spectroradiometer (MODIS) remote sensing images and then simulated the consequent pollution using meteorological and dispersion models. The results show that the crop fires sweeping from the south to the north are responsible for the intensive air pollution during harvest season. It is necessary for scientists and governments to pay more attention to this issue. (letter)

  2. Separation of Fischer-Tropsch Wax Products from Ultrafine Iron Catalyst Particles

    Energy Technology Data Exchange (ETDEWEB)

    James K. Neathery; Gary Jacobs; Amitava Sarkar; Burtron H. Davis

    2006-03-31

    The morphological and chemical nature of ultrafine iron catalyst particles (3-5 nm diameters) during activation/FTS was studied by HRTEM, EELS, and Moessbauer spectroscopy. With the progress of FTS, the carbide re-oxidized to magnetite and catalyst activity gradually decreased. The growth of oxide phase continued and average particle size also increased simultaneously. The phase transformation occurred in a ''growing oxide core'' manner with different nano-zones. The nano-range carbide particles did not show fragmentation or attrition as generally observed in micrometer range particles. Nevertheless, when the dimension of particles reached the micrometer range, the crystalline carbide phase appeared to be sprouted on the surface of magnetite single crystal. In the previous reporting period, a design and operating philosophy was developed for an integrated wax filtration system for a 4 liter slurry bubble column reactor to be used in Phase II of this research program. During the current reporting period, we have started construction of the new filtration system and began modifications to the 4 liter slurry bubble column reactor (SBCR) reactor. The system will utilize a primary wax separation device followed by a Pall Accusep or Membralox ceramic cross-flow membrane. As of this writing, the unit is nearly complete except for the modification of a moyno-type pump; the pump was shipped to the manufacturer to install a special leak-free, high pressure seal.

  3. Characterization of lysozyme adsorption in cellulosic chromatographic materials using small-angle neutron scattering.

    Science.gov (United States)

    Koshari, Stijn H S; Wagner, Norman J; Lenhoff, Abraham M

    2015-06-19

    Measurements of the nanoscale structure of chromatographic adsorbents and the associated distribution of sorbed protein within the media can facilitate improvements in such media. We demonstrate a new technique for this purpose using small-angle neutron scattering (SANS) to characterize the nano- to microscale structure of the chromatographic media and sorbed protein under conditions relevant for preparative chromatographic separations. The adsorption of lysozyme on cellulosic S HyperCel™ (Pall Corporation), a strong cation exchanger, was investigated by SANS. The scattering spectrum is reduced to three contributions arising from (1) the chromatographic medium, (2) discrete protein molecules, and (3) the distribution of sorbed protein within the medium. These contributions are quantified for a range of protein loadings. The total concentration of protein in the chromatographic media can be quantified from the SANS spectrum and the protein is observed to retain its tertiary structure upon adsorption, within the resolution of the method. Further analysis of the SANS spectra shows that protein adsorption is uniform in the media. These measurement techniques provide new and valuable nanoscale information about protein sorption in chromatographic media. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Comparative Study of Predeposit and Bedside Leucodepletion Filters.

    Science.gov (United States)

    Sen, A; Khetarpal Sm, A; Jetley, S

    2010-04-01

    Removal of leucocytes from cellular blood components is associated with reduction of several transfusion associated adverse reactions. A total of 400 units of packed red blood cells (RBCs) were subjected to leucodepletion at room temperature and 4°C using different commercially available prestorage and bedside filters (Terumo Penpol Immugard III and Pall Medical BPF-4). Pre-filtration and post-filtration parameters were compared to assess the efficacy of prestorage leucodepletion vis-à-vis bedside leucodepletion and the requirement of universal leucodepletion. Mean post-filtration red cell recovery ranged from 88.49-93.49% with all bags showing more than 85% red cell recovery. Mean post-filtration residual leucocyte count ranged from 0.205 × 10(6)-0.338 × 10(6)/bag with all bags showing more than log 3 leucoreduction. Prestorage leucoreduction achieved by the polyurethane filter was better than that achieved by the polyester filter. Red cell recovery with the bedside filters at room temperature was significantly less than that with prestorage filters at either temperature. This study suggests that prestorage leucoreduction is preferable over bedside leucoreduction and that polyurethane filters are better than polyester filters since leucodepletion achieved with the former is higher. We recommend selective log 3 leucodepletion using polyurethane prestorage filters for patients with specific indications.

  5. Assessment of prion reduction filters in decreasing infectivity of ultracentrifuged 263K scrapie-infected brain homogenates in "spiked" human blood and red blood cells.

    Science.gov (United States)

    Cardone, Franco; Sowemimo-Coker, Samuel; Abdel-Haq, Hanin; Sbriccoli, Marco; Graziano, Silvia; Valanzano, Angelina; Berardi, Vito Angelo; Galeno, Roberta; Puopolo, Maria; Pocchiari, Maurizio

    2014-04-01

    The safety of red blood cells (RBCs) is of concern because of the occurrence of four transfusion-transmitted variant Creutzfeldt-Jakob disease (vCJD) cases in the United Kingdom. The absence of validated screening tests requires the use of procedures to remove prions from blood to minimize the risk of transmission. These procedures must be validated using infectious prions in a form that is as close as possible to one in blood. Units of human whole blood (WB) and RBCs were spiked with high-speed supernatants of 263K scrapie-infected hamster brain homogenates. Spiked samples were leukoreduced and then passed through prion-removing filters (Pall Corporation). In another experiment, RBCs from 263K scrapie-infected hamsters were treated as above, and residual infectivity was measured by bioassay. The overall removal of infectivity by the filters from prion-spiked WB and RBCs was approximately two orders of magnitude. No infectivity was detected in filtered hamster RBCs endogenously infected with scrapie. The use of prion-removing filters may help to reduce the risk of transfusion-transmitted vCJD. To avoid overestimation of prion removal efficiency in validation studies, it may be more appropriate to use supernates from ultracentrifugation of scrapie-infected hamster brain homogenate rather than the current standard brain homogenates. © 2013 American Association of Blood Banks.

  6. Effect of aerotechnogenic emissions on the content of heavy metals in herbaceous plants of the Lower Don region

    Science.gov (United States)

    Minkina, T. M.; Mandzhieva, S. S.; Chaplygin, V. A.; Motuzova, G. V.; Burachevskaya, M. V.; Bauer, T. V.; Sushkova, S. N.; Nevidomskaya, D. G.

    2017-06-01

    The effect of soil properties and distance from the source of technogenic emission on the input of Pb, Zn, Cd, Cu, Mn, Cr, and Ni into daisy family plants ( Asteraceae) has been studied. It has been found that the high level of anthropogenic load related to the atmospheric emissions from the Novocherkassk power plant (NPP) favors the accumulation of heavy metals (HMs) in herbaceous plants. Contamination with Pb, Cd, Cr, and Ni is revealed in plants growing near the NPP. The main factors affecting the distribution of HMs in the above- and underground organs of plants include individual physiological features of plant species controlling the barrier functions of different plant organs. Ambrosia artemisiifolia L., Artemisia austriaca Pall. ex. Wild. Jack., and Tanacetum vulgare L. are accumulators of HMs. The resistance of herbaceous plants to pollution has been determined from the acropetal coefficient and actual biogeochemical mobility of HMs. Ambrosia artemisiifolia L. is most resistant to contamination with Mn; Achillea nobilis L. is most resistant to Pb, Ni, and Cd; Cichorium intybus L. is most resistant to Zn and Cu.

  7. Quantitative Proteomics Analysis of Herbaceous Peony in Response to Paclobutrazol Inhibition of Lateral Branching.

    Science.gov (United States)

    Zhao, Daqiu; Gong, Saijie; Hao, Zhaojun; Meng, Jiasong; Tao, Jun

    2015-10-14

    Herbaceous peony (Paeonia lactiflora Pall.) is an emerging high-grade cut flower worldwide, which is usually used in wedding bouquets and known as the "wedding flower". However, abundant lateral branches appear frequently in some excellent cultivars, and a lack of a method to remove Paeonia lactiflora lateral branches other than inefficient artificial methods is an obstacle for improving the quality of its cut flowers. In this study, paclobutrazol (PBZ) application was found to inhibit the growth of lateral branches in Paeonia lactiflora for the first time, including 96.82% decreased lateral bud number per branch, 77.79% and 42.31% decreased length and diameter of lateral branches, respectively, declined cell wall materials and changed microstructures. Subsequently, isobaric tag for relative and absolute quantitation (iTRAQ) technology was used for quantitative proteomics analysis of lateral branches under PBZ application and control. The results indicated that 178 differentially expressed proteins (DEPs) successfully obtained, 98 DEPs were up-regulated and 80 DEPs were down-regulated. Thereafter, 34 candidate DEPs associated with the inhibited growth of lateral branches were screened according to their function and classification. These PBZ-stress responsive candidate DEPs were involved in eight biological processes, which played a very important role in the growth and development of lateral branches together with the response to PBZ stress. These results provide a better understanding of the molecular theoretical basis for removing Paeonia lactiflora lateral branches using PBZ application.

  8. Quantitative Proteomics Analysis of Herbaceous Peony in Response to Paclobutrazol Inhibition of Lateral Branching

    Directory of Open Access Journals (Sweden)

    Daqiu Zhao

    2015-10-01

    Full Text Available Herbaceous peony (Paeonia lactiflora Pall. is an emerging high-grade cut flower worldwide, which is usually used in wedding bouquets and known as the “wedding flower”. However, abundant lateral branches appear frequently in some excellent cultivars, and a lack of a method to remove Paeonia lactiflora lateral branches other than inefficient artificial methods is an obstacle for improving the quality of its cut flowers. In this study, paclobutrazol (PBZ application was found to inhibit the growth of lateral branches in Paeonia lactiflora for the first time, including 96.82% decreased lateral bud number per branch, 77.79% and 42.31% decreased length and diameter of lateral branches, respectively, declined cell wall materials and changed microstructures. Subsequently, isobaric tag for relative and absolute quantitation (iTRAQ technology was used for quantitative proteomics analysis of lateral branches under PBZ application and control. The results indicated that 178 differentially expressed proteins (DEPs successfully obtained, 98 DEPs were up-regulated and 80 DEPs were down-regulated. Thereafter, 34 candidate DEPs associated with the inhibited growth of lateral branches were screened according to their function and classification. These PBZ-stress responsive candidate DEPs were involved in eight biological processes, which played a very important role in the growth and development of lateral branches together with the response to PBZ stress. These results provide a better understanding of the molecular theoretical basis for removing Paeonia lactiflora lateral branches using PBZ application.

  9. Styrene biofiltration in a trickle-bed reactor

    Directory of Open Access Journals (Sweden)

    V. Novak

    2008-04-01

    Full Text Available The biological treatment of styrene waste gas in a trickle-bed filter (TBF was investigated. The bioreactor consisted of a two-part glass cylinder (ID 150 mm filled with 25 mm polypropylene Pall rings serving as packing material. The bed height was 1m. Although the laboratory temperature was maintained at 22 ºC, the water temperature in the trickle-bed filter was slightly lower (about 18 ºC.The main aim of our study was to observe the effect of empty-bed residence time (EBRT on bioreactor performance at a constant pollutant concentration over an extended time period. The bioreactor was inoculated with a mixed microbial consortium isolated from a styrene-degrading biofilter that had been running for the previous two years. After three weeks of acclimation period, the bioreactor was loaded with styrene (100 mg.m-3. EBRT was in the range of 53 s to 13 s. A maximum elimination capacity (EC of 11.3 gC.m-3.h-1 was reached at an organic loading (OL rate of 18.6 gC.m-3.h-1.

  10. Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6

    Directory of Open Access Journals (Sweden)

    Li-Na Gao

    2015-01-01

    Full Text Available Peony (Paeonia lactiflora Pall- is a plant medicine and a functional food ingredient with wide application for more than 2000 years. It can be coadministrated with many other drugs, composed of traditional Chinese medicine compound such as shaoyao-gancao decoction. In order to explore the efficacy and safety of peony, effects of paeoniflorin and albiflorin (the principal components of peony on cytochrome P450 (CYP 3A4 and CYP2D6 were analyzed in human hepatoma HepG2 cells and evaluated from the level of recombinant CYP enzymes in vitro. The findings indicated that albiflorin possessed stronger regulation on the mRNA expression of CYP3A4 and CYP2D6 than paeoniflorin. For the protein level of CYP3A4, albiflorin showed significant induction or inhibition with the concentration increasing from 10−7 M to 10−5 M, but no remarkable variation was observed in paeoniflorin-treated group. Enzyme activity assay implied that both paeoniflorin and albiflorin could regulate CYP3A4 and CYP2D6 with varying degrees. The results showed that albiflorin should be given more attention because it may play a vital role on the overall efficacy of peony. The whole behavior of both paeoniflorin and albiflorin should be focused on ensuring the rationality and effectiveness of clinical application.

  11. Symptomology and etiology of a new disease, yellow stunt, and root rot of standing milkvetch caused by Embellisia sp. in Northern China.

    Science.gov (United States)

    Li, Yan Zhong; Nan, Zhi Biao

    2007-06-01

    An Embellisia sp. has been established as the cause of a new disease of the herbaceous perennial forage legume, 'standing milkvetch' (Astragalus adsurgens Pall.) in Northern China, which severely reduces plant density and degrades A. adsurgens stands. The disease was common at an experimental location in Gansu Province where it was recognized by the occurrence of stunted plants with reddish-brown stems and yellow and necrotic leaf blades. An Embellisia sp. was isolated from symptomatic stem, leaf blade, petiole, and root tissues at varying frequencies of up to 90%. Single-spore isolates grew very slowly on PCA, PDA, V-8 and, wheat hay decoction agar. Pathogenicity was confirmed by inoculation of seeds, dipping 2-day-old pre-germinated seedlings in inoculum and spraying inoculum on 6-month-old plants. Symptoms on test plants included yellow leaf lesions, brown lesions on stems and petioles, stunted side-shoots with yellow, small, distorted and necrotic leaves, shoot blight, bud death, crown rot, root rot, and plant death. The disease is named as 'yellow stunt and root rot' of A. adsurgens to distinguish it from diseases caused by other known pathogens. Embellisia sp. is also pathogenic to A. sinicus but not to 11 other tested plant species.

  12. Optimized filtration for reduced defectivity and improved dispense recipe in 193-nm BARC lithography

    Science.gov (United States)

    Do, Phong; Pender, Joe; Lehmann, Thomas; Mc Ardle, Leo P.; Gotlinsky, Barry; Mesawich, Michael

    2004-05-01

    The implementation of 193 nm lithography into production has been complicated by high defectivity issues. Many companies have been struggling with high defect densities, forcing process and lithography engineers to focus their efforts on chemical filtration instead of process development. After-etch defects have complicated the effort to reduce this problem. In particular it has been determined that chemical filtration at the 90 nm node and below is a crucial item which current industry standard pump recipes and material choices are not able to address. LSI Logic and Pall Corporation have been working together exploring alternative materials and resist pump process parameters to address these issues. These changes will free up process development time by reducing these high defect density issues. This paper provides a fundamental understanding of how 20nm filtration combined with optimized resist pump set-up and dispense can significantly reduce defects in 193nm lithography. The purpose of this study is to examine the effectiveness of 20 nanometer rated filters to reduce various defects observed in bottom anti reflective coating materials. Multiple filter types were installed on a Tokyo Electron Limited Clean Track ACT8 tool utilizing two-stage resist pumps. Lithographic performance of the filtered resist and defect analysis of patterned and non-patterned wafers were performed. Optimized pump start-up and dispense recipes also were evaluated to determine their effect on defect improvements. The track system used in this experiment was a standard production tool and was not modified from its original specifications.

  13. Overexpression of herbaceous peony miR156e-3p improves anthocyanin accumulation in transgenic Arabidopsis thaliana lateral branches.

    Science.gov (United States)

    Zhao, Daqiu; Xia, Xing; Wei, Mengran; Sun, Jing; Meng, Jiasong; Tao, Jun

    2017-12-01

    microRNAs (miRNAs) play critical regulatory roles in plant growth and development. In the present study, the function of herbaceous peony ( Paeonia lactiflora Pall.) miR156e-3p in the regulation of color formation has been investigated. Firstly, P. lactiflora miR156e-3p precursor sequence (pre-miR156e-3p) was isolated. Subsequently, the overexpression vector of pre-miR156e-3p was constructed and transformed into Arabidopsis thaliana . Moreover, the medium screening, GUS staining, polymerase chain reaction (PCR) of the GUS region and real-time quantitative PCR (qRT-PCR) of miR156e-3p all confirmed that the purpose gene had been successfully transferred into Arabidopsis plants and expressed, which resulted in apparent purple lateral branches. And this change in color was caused by the improved anthocyanin accumulation. In addition, expression analysis had shown that the level of miR156e-3p transcript was increased, while transcription level of target gene squamosa promoter binding protein-like gene ( SPL1 ), encoding SPL transcription factor that negatively regulated anthocyanin accumulation, was repressed in miR156e-3p-overexpressing transgenic plants, and its downstream gene dihydroflavonol 4-reductase gene ( DFR ) that was directly involved in anthocyanin biosynthesis was strongly expressed, which resulted in anthocyanin accumulation of Arabidopsis lateral branches. These findings would improve the understanding of miRNAs regulation of color formation in P. lactiflora .

  14. Identification of a New Uncompetitive Inhibitor of Adenosine Deaminase from Endophyte Aspergillus niger sp.

    Science.gov (United States)

    Zhang, Xin-Guo; Liu, Jin-Wen; Tang, Peng; Liu, Zi-Yu; Guo, Guang-Jun; Sun, Qiao-Yun; Yin, Jian-Jun

    2018-05-01

    Adenosine deaminase (ADA) is an enzyme widely distributed from bacteria to humans. ADA is known as a potential therapeutic target for the treatment of lymphoproliferative disorders and cancer. Endophytes are endosymbionts, often bacteria or fungi, which live within plant tissues and internal organs or intercellular space. Endophytes have a broad variety of bioactive metabolites that are used for the identification of novel natural compounds. Here, 54 morphologically distinct endophyte strains were isolated from six plants such as Peganum harmala Linn., Rheum officinale Baill., Gentiana macrophylla Pall., Radix stephaniae tetrandrae, Myrrha, and Equisetum hyemale Linn. The isolated strains were used for the search of ADA inhibitors that resulted in the identification of the strain with the highest inhibition activity, Aspergillus niger sp. Four compounds were isolated from this strain using three-step chromatography procedure, and compound 2 was determined as the compound with the highest inhibition activity of ADA. Based on the results of 1 H and 13 C NMR spectroscopies, compound 2 was identified as 3-(4-nitrophenyl)-5-phenyl isoxazole. We showed that compound 2 was a new uncompetitive inhibitor of ADA with high cytotoxic effect on HepG2 and SMCC-7721 cells (the IC 50 values were 0.347 and 0.380 mM, respectively). These results suggest that endophyte strains serve as promising sources for the identification of ADA inhibitors, and compound 2 could be an effective drug in the cancer treatment.

  15. Performance linked to residence time distribution by a novel wool-based bioreactor for tertiary sewage treatment.

    Science.gov (United States)

    Hu, Bibo; Wheatley, Andrew; Ishtchenko, Vera; Huddersman, Katherine

    2012-05-01

    Laboratory-scale experiments were carried out using up-flow 7 L Submerged Aerated Filter reactors packed with wool fibre or commercial plastic pall rings, Kaldnes, (70% by volume) support media for the tertiary treatment of sewage. The performance of the wool bioreactor was more consistent than that with Kaldnes medium, for both TOC removal (93%) and SS removal (90%). Both plastic and wool-packed bioreactors achieved complete nitrification at the load of about 0.4 kgCOD/m(3)/day. The sludge yield of the wool bioreactor was almost half that of the bioreactor with Kaldnes suggesting that wool could retain residual organics and particulates. The wool however was degraded and it was concluded that wool would have to be considered as additional sacrificial adsorption capacity rather than an alternative medium. The performance was linked to the residence time distribution studies and these changes in the wool structure. Biomass growth increased the retention of the tracer in the wool reactor by, it was suggested, exposing a greater surface area. Results from the plastic media on the other hand showed increased mixing possibly by increasing the mobility of the plastic. Aeration increased the mixing in both reactors, and patterns were in all cases predominantly well-mixed.

  16. Essential oil composition and antioxidant activity of two Juniperus communis L. varieties growing wild in Serbia

    Directory of Open Access Journals (Sweden)

    Rajčević Nemanja F.

    2016-01-01

    Full Text Available The genus Juniperus L. (Cupressaceae consists of ca. 67 species and 34 varieties. Juniperus communis L. grows on dry hills or mountainous tracts and is widely distributed in the northern hemisphere. A typical variety J. communis L. var. communis was collected in Deliblatska peščara (Deliblato Sands and variety J. communis L. var. saxatilis Pall. in Kopaonik Mountain. Needle essential oils were obtained using Clevenger apparatus and analyzed using GC/MS and GC/FID. Antioxidant activity of essential oils was evaluated using DPPH assay. A total of 78 compounds were detected and identified. Both oils are characterized by high abundance of monoterpenes. The main constituents of J. communis var. communis essential oil were sabinene (39.4%, α-pinene (13.3%, myrcene (4.7% and terpinen-4-ol (3.7%, while J. communis var. saxatilis essential oil had α-pinene (34.9%, sabinene (20.3%, δ-3-carene (6.4% and germacrene B (6.3% as the most abundant components. DPPH test showed IC50 values 0.66 mg/ml for J. communis var. communis and 0.32 mg/ml for J. communis var. saxatilis. Although antioxidant activity was weaker than used standards (BHT and L-ascorbic acid it is still significant.

  17. Cómo explicar física cuántica con un gato zombi

    CERN Document Server

    Gonzalez Buron, Helena; Marimon Garrido, Oriol; Barrrecheguran Manero, Pablo; Luri Carrascoso, Xavier; Puerto Gimenez, Irene; Saenz de Cabezon Irigarai, Eduardo

    2016-01-01

    ¿Sabías que el teletransporte es real? ¿Que a veces un electrón tiene probabilidades de atravesar una pared? ¿Que dos partículas pueden influenciarse mutuamente aunque estén a años luz de distancia? ¿Y que las partículas cuánticas son como Clark Kent y disimulan sus poderes cuando los científicos las están observando? En Cómo explicar la física cuántica con un gato zombi descubrirás que, aunque no lo parezca, la física cuántica está por todas partes en nuestra vida cotidiana. Y además aprenderás... ...¡los principios más locos y flipantes de la física cuántica! ...¡experimentos low cost que puedes hacer en tu casa! ...que los científicos están un poco pallá, ¿lo sabías? ...y que los gatos tampoco son muy normales que digamos...

  18. Isolation, identification and antagonistic activity evaluation of actinomycetes in barks of nine trees

    Directory of Open Access Journals (Sweden)

    Wang Dong-sheng

    2017-01-01

    Full Text Available Actinomycetes are important producers of novel bioactive compounds. New sources need to be explored for isolating previously unknown bioactive compound-producing actinomycetes. Here we evaluated the potential of bark as a natural source of novel bioactive actinomycete species. Bark samples were collected from nine tree species at different elevations (1600-3400 ma.s.l. on Qin Mountain, Shaanxi Province, China. Actinomycetes were cultivated, enumerated and isolated using serial dilution and spread-plate techniques. The antimicrobial activity of actinomycete isolates was analyzed using an agar block method against 15 typical bacterial and fungal species and plant pathogens. The dominant isolates were identified by 16S rRNA-based sequence analysis. Results showed that actinomycete counts in bark samples of Quercus liaotungensis Koidz. was the highest among all trees species tested. The numbers of actinomycete species in bark samples were highest in Q. aliena var. acutiserrata and Spiraea alpina Pall. Antagonistic activity wasdetected in approximately 54% of the actinomycete isolates. Of these, 20 isolates (25% showed broad-spectrum antagonistic activity against ≥5 of the microorganisms tested. In conclusion, the bark on coniferous and broadleaf trees possesses a high diversity of actinomycetes and serves as a natural source of bioactive compound-producing actinomycetes.

  19. Depressão e qualidade de vida em pacientes com fibromialgia Depression and quality of life among patients with fibromyalgia

    Directory of Open Access Journals (Sweden)

    AMB Santos

    2006-09-01

    Full Text Available CONTEXTO: Fibromialgia é uma síndrome reumática caracterizada por dor musculoesquelética difusa e crônica, e sítios dolorosos específicos à palpação (tender points. Freqüentemente é associada à fadiga generalizada, distúrbios do sono, rigidez matinal, dispnéia, ansiedade, alterações no humor que podem evoluir para um quadro de depressão. Sendo assim, afeta negativamente a qualidade de vida das pessoas. No entanto, ainda não se sabe o poder de discriminação dos instrumentos de avaliação da depressão e qualidade de vida. O objetivo desse estudo foi avaliar a depressão e a qualidade de vida de pacientes com fibromialgia e avaliar o poder de discriminação de instrumentos relacionados a esses aspectos. MÉTODO: Para avaliar a qualidade de vida foram utilizados dois instrumentos: um específico, o Fibromyalgia Impact Questionnaire (FIQ e outro genérico, o Medical Outcomes Study 36-item Short-Form Healthy Survey (SF-36; para avaliar a depressão, a Escala de Depressão de Beck (BDS. Participaram do estudo 40 mulheres sendo 20 com fibromialgia - Grupo teste e 20 saudáveis - Grupo controle. Os três protocolos foram aplicados aos indivíduos dos dois grupos em uma única sessão de avaliação. Toda a análise estatística foi realizada utilizando-se o teste "t" Student, com significância alfa = 0,05. RESULTADOS: Houve diferença estatisticamente significante entre os grupos controle e teste em todos os questionários (pBACKGROUND: Fibromyalgia is a rheumatic syndrome characterized by widespread chronic musculoskeletal pain and specific palpable tender points. It is often associated with generalized fatigue, sleep disturbances, morning stiffness, dyspnea, anxiety and mood disturbances that may evolve into depression. Thus, such individuals' quality of life is negatively affected. However, the discriminating power of quality-of-life and depression assessment instruments is still unknown. OBJECTIVE: To assess depression and

  20. Triggered massive star formation associated with the bubble Hii region Sh2-39 (N5)

    Science.gov (United States)

    Duronea, N. U.; Cappa, C. E.; Bronfman, L.; Borissova, J.; Gromadzki, M.; Kuhn, M. A.

    2017-09-01

    Aims: We perform a multiwavelength analysis of the bubble Hii region Sh2-39 (N5) and its environs with the aim of studying the physical properties of Galactic IR bubbles and exploring their impact in triggering massive star formation. Methods: To analyze the molecular gas, we used CO(3-2) and HCO+(4-3) line data obtained with the on-the-fly technique from the ASTE telescope. To study the distribution and physical characteristics of the dust, we made use of archival data from ATLASGAL, Herschel, and MSX, while the ionized gas was studied making use of an NVSS image. We used public WISE, Spitzer, and MSX point source catalogs to search for infrared candidate young stellar objects (YSOs) in the region. To investigate the stellar cluster [BDS2003]6 we used IR spectroscopic data obtained with the ARCoIRIS spectrograph, mounted on Blanco 4 m Telescope at CTIO, and new available IR Ks band observations from the VVVeXtended ESO Public Survey (VVVX). Results: The new ASTE observations allowed the molecular gas component in the velocity range from 30 km s-1 to 46 km s-1, associated with Sh2-39, to be studied in detail. The morphology of the molecular gas suggests that the ionized gas is expanding against its parental cloud. We identified four molecular clumps, which were likely formed by the expansion of the ionization front, and determined some of their physical and dynamical properties. Clumps with HCO+ and 870 μm counterparts show evidence of gravitational collapse. We identified several candidate YSOs across the molecular component. Their spatial distribution and the fragmentation time derived for the collected layers of the molecular gas suggest that massive star formation might have been triggered by the expansion of the nebula via the collect and collapse mechanism. The spectroscopical distance obtained for the stellar cluster [BDS2003]6, placed over one of the collapsing clumps in the border of the Hii region, reveals that this cluster is physically associated with

  1. Screening of novel yeast inulinases and further application to bioprocesses.

    Science.gov (United States)

    Paixão, Susana M; Teixeira, Pedro D; Silva, Tiago P; Teixeira, Alexandra V; Alves, Luís

    2013-09-25

    Inulin is a carbohydrate composed of linear chains of β-2,1-linked D-fructofuranose molecules terminated by a glucose residue through a sucrose-type linkage at the reducing end. Jerusalem artichoke (JA) is one of the most interesting materials among unconventional and renewable raw materials, with levels of inulin reaching 50-80% of dry matter. Inulin or inulin-rich materials can be actively hydrolyzed by microbial inulinases to produce glucose and fructose syrups that can be used in bioprocesses. In this study, several microbial strains were isolated and their ability to inulinase biosynthesis was evaluated. The novel yeast strain Talf1, identified as Zygosaccharomyces bailii, was the best inulinase producer, attaining 8.67 U/ml of inulinase activity when JA juice was used as the inducer substrate. Z. bailii strain Talf1 and/or its enzymatic crude extract were further applied for bioethanol production and biodesulfurization (BDS) processes, using inulin and JA juice as carbon source. In a consolidated bioprocessing for ethanol production from 200 g/l inulin, Z. bailii strain Talf1 was able to produce 67 g/l of ethanol. This ethanol yield was improved in a simultaneous saccharification and fermentation (SSF) process, with the ethanologenic yeast Saccharomyces cerevisiae CCMI 885 and the Talf1 inulinases, achieving a production of 78 g/l ethanol. However, the highest ethanol yield (∼48%) was obtained in a SSF process from JA juice (∼130 g/l fermentable sugars), where the S. cerevisiae produced 63 g/l ethanol. Relatively to the dibenzothiophene BDS tests, the Gordonia alkanivorans strain 1B achieved a desulfurization rate of 4.8 μM/h within a SSF process using Talf1 inulinases and JA juice, highlighting the potential of JA as a less expensive alternative carbon source. These results showed the high potential of Z. bailii strain Talf1 inulinases as a versatile tool for bioprocesses using inulin-rich materials. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Comparison of inductively coupled plasma mass spectrometry and colorimetric determination of total and extractable phosphorus in soils

    International Nuclear Information System (INIS)

    Ivanov, Krasimir; Zaprjanova, Penka; Petkova, Milena; Stefanova, Violeta; Kmetov, Veselin; Georgieva, Deyana; Angelova, Violina

    2012-01-01

    The most widely used method for determination of total phosphorus in soils is perchloric acid digestion, followed by a colorimetric assay to measure the concentration of P in solution. The first part of this study compares an alternative digestion method, using aqua regia (ISO 11466 and EPA Method 3052), with perchloric acid digestion procedure, and also compares inductively coupled plasma mass spectroscopy (ICP-MS) with colorimetry for the measurement of P on the basis of five internationally certified standard soils and 20 real-life soils with widely different extractability of phosphorus. The phosphorus concentration was determined by means of the reduced phosphomolybdenum blue and ICP-MS. The relationship between methods has been examined statistically. Good agreement of the results from colorimetry and ICP-MS was established for all certified soils. The microwave-assisted digestion with aqua regia was comparable, both in precision and accuracy, with the hot plate aqua regia method. The phosphorus concentration found with the HF + HClO 4 digestion method was in good agreement with the certified mean values, while the superiority in extracting phosphorus, when compared to other methods, was obvious. Soil testing for plant-available phosphorus in Bulgaria and many European countries is most commonly conducted using acid Ca-lactate extraction (Egner–Riehm test) and alkaline sodium bicarbonate extraction (BDS ISO 11263:2002), based on Olsen test, followed by a colorimetric assay to measure the concentration of P in solution. The second part of this study reports the differences between Egner–Riehm test and BDS ISO 11263:2002 measured colorimetrically and by ICP-MS. Fifty soils were selected from South Bulgaria to represent a wide range of soil properties. It was established that ICP-MS consistently yielded significantly higher P concentrations than the colorimetric method in both extraction tests, and the relative differences were greatest in soils with lower P

  3. Validation of the Revised Illness Perception Questionnaire in Turkish epilepsy patients and the effects of earthquake experience on perception of disease

    Directory of Open Access Journals (Sweden)

    Keskin Güler S

    2017-02-01

    Full Text Available Selda Keskin Güler,1 Sertac Güler,2 Burcu Gökçe Çokal,1 Nalan Gunes,1 Mehmet İlker Yon,1 Tahir Kurtulus Yoldas1 1Department of Neurology, 2Department of Emergency Medicine, Ankara Training and Research Hospital, Ankara, Turkey Objective: The aims of this study were to investigate the reliability of the Revised Illness Perception Questionnaire (IPQ-R in Turkish patients with epilepsy (PWE and to determine the effects of earthquake experience on the perception of disease in patients.Materials and methods: The sample was composed of 48 PWE, who were affected by the 2011 earthquake (n=21 or who had never had any earthquake experience (n=27. The interview form, IPQ-R, and Beck Depression Scale (BDS were applied.Results: The study was carried out on PWE whose mean age was 20.9 years (±8.1 years and who had been diagnosed within the last 10 years (±6.9 years. IPQ-R consisted of three parts: illness identity, attributions concerning the disease, and probable causes. In the part of illness identity, the most frequently met manifestations were fatigue (76.6% and headache (72.9%. Regarding attributions concerning the disease and probable causes, the test was determined to be reliable (reliability coefficient 0.715–0.814. In terms of personal control, timeline (acute/chronic, emotional representations, illness coherence, consequences, treatment control, and timeline subscales, which were investigated at the dimension about attributions concerning the disease, and psychological causal attributions, risk factors, and immunity subscales, which were investigated at the dimension about probable causes, no significant differences were found between groups (P>0.05. No difference was determined in terms of BDS scores (z=−0.895, P>0.05.Conclusion: The results of this study demonstrated that IPQ-R could be used reliably in the Turkish PWE. A severe life event such as an earthquake did not change IPQ-R scores in PWE. Keywords: epilepsy, Revised Illness

  4. How many replicate tests do I need?$-$ Variability of cookstove performance and emissions has implications for obtaining useful results

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yungang [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division; Sohn, Michael D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division; Gadgil, Ashok J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division; Wang, Yilun [ISO Innovative Analytics San Francisco, CA (United States); Lask, Kathleen M. [Univ. of California, Berkeley, CA (United States). College of Engineering Applied Science and Technology Program; Kirchstetter, Thomas W. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division

    2013-02-01

    Almost half of the world’s population still cooks on biomass cookstoves of poor efficiency and primitive design, such as three stone fires (TSF). Emissions from biomass cookstoves contribute to adverse health effects and climate change. A number of “improved cookstoves” with higher energy efficiency and lower emissions have been designed and promoted across the world. During the design development, and for selection of a stove for dissemination, the stove performance and emissions are commonly evaluated, communicated and compared using the arithmetic average of replicate tests made using a standardized laboratory-based test, commonly the water boiling test (WBT). However, published literature shows different WBT results reported from different laboratories for the same stove technology. Also, there is no agreement in the literature on how many replicate tests should be performed to ensure “significance” in the reported average performance. This matter has not received attention in the rapidly growing literature on stoves, and yet is crucial for estimating and communicating the performance of a stove, and for comparing the performance between stoves. We present results of statistical analyses using data from a number of replicate tests of performance and emission of the Berkeley-Darfur Stove (BDS) and the TSF under well-controlled laboratory conditions. We observed moderate variability in the test results for the TSF and BDS when measuring several characteristics. Here we focus on two as illustrative: time-to-boil and PM2.5 (particulate matter less than or equal to 2.5 micrometers in diameter) emissions. We demonstrate that interpretation of the results comparing these stoves could be misleading if only a small number of replicates had been conducted. We then describe a practical approach, useful to both stove testers and designers, to assess the number of replicates needed to obtain useful data. Caution should be exercised in attaching high credibility to

  5. The Effects of a Brief Acceptance-based Behavior Therapy vs. Traditional Cognitive Behavior Therapy for Public Speaking Anxiety: Differential Effects on Performance and Verbal Working Memory

    Science.gov (United States)

    Glassman, Lisa Hayley

    Individuals with public speaking phobia experience fear and avoidance that can cause extreme distress, impaired speaking performance, and associated problems in psychosocial functioning. Most extant interventions for public speaking phobia focus on the reduction of anxiety and avoidance, but neglect performance. Additionally, very little is known about the relationship between verbal working memory and social performance under conditions of high anxiety. The current study compared the efficacy of two cognitive behavioral treatments, traditional Cognitive Behavioral Therapy (tCBT) and acceptance-based behavior therapy (ABBT), in enhancing public speaking performance via coping with anxiety. Verbal working memory performance, as measured by the backwards digit span (BDS), was measured to explore the relationships between treatment type, anxiety, performance, and verbal working memory. We randomized 30 individuals with high public speaking anxiety to a 90-minute ABBT or tCBT intervention. As this pilot study was underpowered, results are examined in terms of effect sizes as well as statistical significance. Assessments took place at pre and post-intervention and included self-rated and objective anxiety measurements, a behavioral assessment, ABBT and tCBT process measures, and backwards digit span verbal working memory tests. In order to examine verbal working memory during different levels of anxiety and performance pressure, we gave each participant a backwards digit span task three times during each assessment: once under calm conditions, then again while experiencing anticipatory anxiety, and finally under conditions of acute social performance anxiety in front of an audience. Participants were asked to give a video-recorded speech in front of the audience at pre- and post-intervention to examine speech performance. Results indicated that all participants experienced a very large and statistically significant decrease in anxiety (both during the speech and BDS

  6. Assessment of anxiety and depression in adolescents with acne vulgaris related to the severity of clinical features and gender

    Directory of Open Access Journals (Sweden)

    Nermina Kurtalić

    2010-11-01

    Full Text Available Objective. To determine anxiety and depression levels in adolescents with acne vulgaris in relation to clinical severity and gender. Patients and methods. Using a sectional study, the anxiety and depression level was analyzed of 90 adolescents of both sexes, aged 16 to 21 years, who were suffering from acne vulgaris. The study was conducted between February 1st 2008 and January 31st 2009 at the Dermatovenerology department of the Cantonal Hospital “Dr. Irfan Ljubijankić”, Bihac. According to the type of efflorescence, its localization and severity of clinical features, respondents were classified in three groups: the first group consisted of adolescents with mild forms of acne, the second group had moderate forms of acne and the third had severe forms of acne. Evaluation of anxiety levels in patients with acne vulgaris was made using STAI questionnaire (Spielberger’s state and trait Anxiety Inventory that consists of 20 questions about the essential characteristics of anxiety as the condition, and the level of depression was determined using the BDS-scale (Back Depression Inventory which consists of 18 items that were used by the respondents to perform self-evaluation of depression level. Results. In the study group there were 54 (60% female respondents and 36 (40% male, mean age 17.5 years (range 15.6-20.6. Of the total number of patients with acne vulgaris, nine of them or 10% (4 female and 5 male had a mild form of acne (first group, 72 of them or 80% (46 female and 26 male a moderate form of acne (second group and 9 of them or 10 % (4 female and 5 male a severe form of acne (third group (p > 0.95. 1.1% of the respondents had an exceptionally low anxiety level, 13.3% had low level, moderate 76.8% and 8.8% had a high level. 37.8% had distinct signs of depression, the risk group consisted of 44.4%, and a normal value was found in 17.7%. The values of the STAI questionnaire expressed as median (range in the first, second and third groups

  7. Orbit determination of the Next-Generation Beidou satellites with Intersatellite link measurements and a priori orbit constraints

    Science.gov (United States)

    Ren, Xia; Yang, Yuanxi; Zhu, Jun; Xu, Tianhe

    2017-11-01

    Intersatellite Link (ISL) technology helps to realize the auto update of broadcast ephemeris and clock error parameters for Global Navigation Satellite System (GNSS). ISL constitutes an important approach with which to both improve the observation geometry and extend the tracking coverage of China's Beidou Navigation Satellite System (BDS). However, ISL-only orbit determination might lead to the constellation drift, rotation, and even lead to the divergence in orbit determination. Fortunately, predicted orbits with good precision can be used as a priori information with which to constrain the estimated satellite orbit parameters. Therefore, the precision of satellite autonomous orbit determination can be improved by consideration of a priori orbit information, and vice versa. However, the errors of rotation and translation in a priori orbit will remain in the ultimate result. This paper proposes a constrained precise orbit determination (POD) method for a sub-constellation of the new Beidou satellite constellation with only a few ISLs. The observation model of dual one-way measurements eliminating satellite clock errors is presented, and the orbit determination precision is analyzed with different data processing backgrounds. The conclusions are as follows. (1) With ISLs, the estimated parameters are strongly correlated, especially the positions and velocities of satellites. (2) The performance of determined BDS orbits will be improved by the constraints with more precise priori orbits. The POD precision is better than 45 m with a priori orbit constrain of 100 m precision (e.g., predicted orbits by telemetry tracking and control system), and is better than 6 m with precise priori orbit constraints of 10 m precision (e.g., predicted orbits by international GNSS monitoring & Assessment System (iGMAS)). (3) The POD precision is improved by additional ISLs. Constrained by a priori iGMAS orbits, the POD precision with two, three, and four ISLs is better than 6, 3, and 2

  8. Flavor Dependence of Hadroproduced Charm Strange Mesons

    Energy Technology Data Exchange (ETDEWEB)

    Jedicke, Robert [Toronto U.

    1992-01-01

    Experiment 769 at the Tagged Photon Laboratory of the Fermi National Accelerator Laboratory wrote approximately 400x$10^6$ events to tape from the reactions of a tagged hadronic beam consisting of $\\pi$, K and p. The interactions took place within a foil target assembly including targets ofW, Be, Cu and Al. We use the D8 meson to determine ifthere exists a dependence of the production properties of the meson on the incident beam particle flavour. A total sample of 83±13 $D_s$ mesons in the $\\phi \\pi$ and $K^* K$ decay modes yields 29±8, 15±5 and 5.6±4.2 $D_s$ mesons using only the transverse energy trigger for the $\\pi$, K and p beams respectively. This is the world's largest sample of kaon induced $D_s$ mesons. This indicates an average $\\sigma$ •B (normalizing B($D_s \\to tK^*K$) to B($D_s \\to \\phi \\pi$)) over the two modes of 0.036±0.015μb/nucleon, 0.044±0.018μb/nucleon and 0.035±0.025μb/nucleon for each of the three different beam particles respectively using $A^{0.95 ± 0.05}$ for $X_F$ > O. These values are consistent with recent measurements by the ACCMOR collaboration at CERN. The absolute cross sections for production of $D_s$ by each of the three beam particles are calculated using the world average of the branching ratio to the $\\phi \\pi$ decay mode. Assuming that all systematic errors cancel, the ratio of the K to $\\pi$ absolute $D_s$ production cross section is found to be 1.2 ± 0.7 for $X_F$ > O. The $X_F$ and $PT^2$ distributions of the Ds mesons for all three beam particles are also presented. All of these results are compared to QCD predictions as well as the LUND Monte Carlo. The differential distributions are consistent to within errors with other experimental results. We find no evidence for a flavour dependence of the production of the $D_s$ meson in the total and differential cross sections.

  9. Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking.

    Science.gov (United States)

    Cervera-Juanes, Rita; Wilhelm, Larry J; Park, Byung; Grant, Kathleen A; Ferguson, Betsy

    2017-05-01

    Alcohol-use disorders encompass a range of drinking levels and behaviors, including low, binge, and heavy drinking. In this regard, investigating the neural state of individuals who chronically self-administer lower doses of alcohol may provide insight into mechanisms that prevent the escalation of alcohol use. DNA methylation is one of the epigenetic mechanisms that stabilizes adaptations in gene expression and has been associated with alcohol use. Thus, we investigated DNA methylation, gene expression, and the predicted neural effects in the nucleus accumbens core (NAcc) of male rhesus macaques categorized as "low" or "binge" drinkers, compared to "alcohol-naïve" and "heavy" drinkers based on drinking patterns during a 12-month alcohol self-administration protocol. Using genome-wide CpG-rich region enrichment and bisulfite sequencing, the methylation levels of 2.6 million CpGs were compared between alcohol-naïve (AN), low/binge (L/BD), and heavy/very heavy (H/VHD) drinking subjects (n = 24). Through regional clustering analysis, we identified nine significant differential methylation regions (DMRs) that specifically distinguished ANs and L/BDs, and then compared those DMRs among H/VHDs. The DMRs mapped to genes encoding ion channels, receptors, cell adhesion molecules, and cAMP, NF-κβ and Wnt signaling pathway proteins. Two of the DMRs, linked to PDE10A and PKD2L2, were also differentially methylated in H/VHDs, suggesting an alcohol-dose independent effect. However, two other DMRs, linked to the CCBE1 and FZD5 genes, had L/BD methylation levels that significantly differed from both ANs and H/VHDs. The remaining five DMRs also differentiated L/BDs and ANs. However, H/VHDs methylation levels were not distinguishable from either of the two groups. Functional validation of two DMRs, linked to FZD5 and PDE10A, support their role in regulating gene expression and exon usage, respectively. In summary, the findings demonstrate that L/BD is associated with unique

  10. Magellan adaptive optics first-light observations of the exoplanet β PIC b. I. Direct imaging in the far-red optical with MagAO+VisAO and in the near-IR with NICI {sup ,}

    Energy Technology Data Exchange (ETDEWEB)

    Males, Jared R.; Close, Laird M.; Morzinski, Katie M.; Skemer, Andrew J.; Kopon, Derek; Follette, Katherine B.; Hinz, Philip M.; Rodigas, Timothy J. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Wahhaj, Zahed [European Southern Observatory, Alonso de Cordova 3107, Vitacura, Casilla 19001 Santiago (Chile); Liu, Michael C.; Nielsen, Eric L.; Chun, Mark [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Puglisi, Alfio; Esposito, Simone; Riccardi, Armando; Pinna, Enrico; Xompero, Marco; Briguglio, Runa [Arcetri Observatory/INAF, Largo E. Fermi 5, I-50125-Firenze (Italy); Biller, Beth A. [Institute for Astronomy, The University of Edinburgh, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Hayward, Thomas L., E-mail: jrmales@as.arizona.edu [Gemini Observatory, Southern Operations Center, c/o AURA, Casilla 603, La Serena (Chile); and others

    2014-05-01

    We present the first ground-based CCD (λ < 1 μm) image of an extrasolar planet. Using the Magellan Adaptive Optics system's VisAO camera, we detected the extrasolar giant planet β Pictoris b in Y-short (Y{sub S} , 0.985 μm), at a separation of 0.470 ± 0.''010 and a contrast of (1.63 ± 0.49) × 10{sup –5}. This detection has a signal-to-noise ratio of 4.1 with an empirically estimated upper limit on false alarm probability of 1.0%. We also present new photometry from the Gemini Near-Infrared Coronagraphic Imager instrument on the Gemini South telescope, in CH {sub 4S,1%} (1.58 μm), K{sub S} (2.18 μm), and K {sub cont} (2.27 μm). A thorough analysis of our photometry combined with previous measurements yields an estimated near-IR spectral type of L2.5 ± 1.5, consistent with previous estimates. We estimate log (L {sub bol}/L {sub ☉}) = –3.86 ± 0.04, which is consistent with prior estimates for β Pic b and with field early-L brown dwarfs (BDs). This yields a hot-start mass estimate of 11.9 ± 0.7 M {sub Jup} for an age of 21 ± 4 Myr, with an upper limit below the deuterium burning mass. Our L {sub bol}-based hot-start estimate for temperature is T {sub eff} = 1643 ± 32 K (not including model-dependent uncertainty). Due to the large corresponding model-derived radius of R = 1.43 ± 0.02 R {sub Jup}, this T {sub eff} is ∼250 K cooler than would be expected for a field L2.5 BD. Other young, low-gravity (large-radius), ultracool dwarfs and directly imaged EGPs also have lower effective temperatures than are implied by their spectral types. However, such objects tend to be anomalously red in the near-IR compared to field BDs. In contrast, β Pic b has near-IR colors more typical of an early-L dwarf despite its lower inferred temperature.

  11. Magellan adaptive optics first-light observations of the exoplanet β PIC b. I. Direct imaging in the far-red optical with MagAO+VisAO and in the near-IR with NICI ,

    International Nuclear Information System (INIS)

    Males, Jared R.; Close, Laird M.; Morzinski, Katie M.; Skemer, Andrew J.; Kopon, Derek; Follette, Katherine B.; Hinz, Philip M.; Rodigas, Timothy J.; Wahhaj, Zahed; Liu, Michael C.; Nielsen, Eric L.; Chun, Mark; Puglisi, Alfio; Esposito, Simone; Riccardi, Armando; Pinna, Enrico; Xompero, Marco; Briguglio, Runa; Biller, Beth A.; Hayward, Thomas L.

    2014-01-01

    We present the first ground-based CCD (λ < 1 μm) image of an extrasolar planet. Using the Magellan Adaptive Optics system's VisAO camera, we detected the extrasolar giant planet β Pictoris b in Y-short (Y S , 0.985 μm), at a separation of 0.470 ± 0.''010 and a contrast of (1.63 ± 0.49) × 10 –5 . This detection has a signal-to-noise ratio of 4.1 with an empirically estimated upper limit on false alarm probability of 1.0%. We also present new photometry from the Gemini Near-Infrared Coronagraphic Imager instrument on the Gemini South telescope, in CH 4S,1% (1.58 μm), K S (2.18 μm), and K cont (2.27 μm). A thorough analysis of our photometry combined with previous measurements yields an estimated near-IR spectral type of L2.5 ± 1.5, consistent with previous estimates. We estimate log (L bol /L ☉ ) = –3.86 ± 0.04, which is consistent with prior estimates for β Pic b and with field early-L brown dwarfs (BDs). This yields a hot-start mass estimate of 11.9 ± 0.7 M Jup for an age of 21 ± 4 Myr, with an upper limit below the deuterium burning mass. Our L bol -based hot-start estimate for temperature is T eff = 1643 ± 32 K (not including model-dependent uncertainty). Due to the large corresponding model-derived radius of R = 1.43 ± 0.02 R Jup , this T eff is ∼250 K cooler than would be expected for a field L2.5 BD. Other young, low-gravity (large-radius), ultracool dwarfs and directly imaged EGPs also have lower effective temperatures than are implied by their spectral types. However, such objects tend to be anomalously red in the near-IR compared to field BDs. In contrast, β Pic b has near-IR colors more typical of an early-L dwarf despite its lower inferred temperature.

  12. Calorimetric and relaxation properties of xylitol-water mixtures

    Science.gov (United States)

    Elamin, Khalid; Sjöström, Johan; Jansson, Helén; Swenson, Jan

    2012-03-01

    We present the first broadband dielectric spectroscopy (BDS) and differential scanning calorimetry study of supercooled xylitol-water mixtures in the whole concentration range and in wide frequency (10-2-106 Hz) and temperature (120-365 K) ranges. The calorimetric glass transition, Tg, decreases from 247 K for pure xylitol to about 181 K at a water concentration of approximately 37 wt. %. At water concentrations in the range 29-35 wt. % a plentiful calorimetric behaviour is observed. In addition to the glass transition, almost simultaneous crystallization and melting events occurring around 230-240 K. At higher water concentrations ice is formed during cooling and the glass transition temperature increases to a steady value of about 200 K for all higher water concentrations. This Tg corresponds to an unfrozen xylitol-water solution containing 20 wt. % water. In addition to the true glass transition we also observed a glass transition-like feature at 220 K for all the ice containing samples. However, this feature is more likely due to ice dissolution [A. Inaba and O. Andersson, Thermochim. Acta, 461, 44 (2007)]. In the case of the BDS measurements the presence of water clearly has an effect on both the cooperative α-relaxation and the secondary β-relaxation. The α-relaxation shows a non-Arrhenius temperature dependence and becomes faster with increasing concentration of water. The fragility of the solutions, determined by the temperature dependence of the α-relaxation close to the dynamic glass transition, decreases with increasing water content up to about 26 wt. % water, where ice starts to form. This decrease in fragility with increasing water content is most likely caused by the increasing density of hydrogen bonds, forming a network-like structure in the deeply supercooled regime. The intensity of the secondary β-relaxation of xylitol decreases noticeably already at a water content of 2 wt. %, and at a water content above 5 wt. % it has been replaced by a

  13. Preparation and dielectric properties of BaCu(B{sub 2}O{sub 5})-doped SrTiO{sub 3}-based ceramics for energy storage

    Energy Technology Data Exchange (ETDEWEB)

    Li, Lingxia, E-mail: lilx106@163.com; Yu, Xiaoxu; Cai, Haocheng; Liao, Qingwei; Han, Yemei; Gao, Zhengdong

    2013-12-01

    Highlights: • BaCu(B{sub 2}O{sub 5}) is added to the multi-ions doped SrTiO{sub 3} ceramics as sintering aid. • The sintering temperature is decreased from 1300 °C to 1075 °C. • The incorporation of Ba{sup 2+} into the matrix increases the dielectric constant. • The breakdown strength increases due to the decrease of grain size and porosity. • The dissolution of BCB contributes to the improvement of dielectric properties. -- Abstract: BaCu(B{sub 2}O{sub 5}) (BCB) was used as sintering aids to lower the sintering temperature of multi-ions doped SrTiO{sub 3} ceramics effectively from 1300 °C to 1075 °C by conventional solid state method. The effect of BCB content on crystalline structures, microstructures and properties of the ceramics was investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and dielectric measurements, respectively. The addition of BCB enhanced the breakdown strength (BDS) while did not sacrifice the dielectric constant. The enhancement of BDS should be due to the modification of microstructures, i.e., smaller and more homogeneous grain sizes after BCB addition. The dielectric constant of BCB-doped ceramics maintained a stable value with 1.0 mol% BCB, which was dominated by the combination of two opposite effects caused by the presence of second phases and the incorporation of Cu{sup 2+} and Ba{sup 2+}, while further increase was owing to the increase of dissolved Ba{sup 2+} ions when the content of BCB is more than 2.0 mol%. The multi-ions doped SrTiO{sub 3} ceramics with 1.0 mol% BCB addition showed optimal dielectric properties as follows: dielectric constant of 311.37, average breakdown strength of 28.78 kV/mm, discharged energy density of 1.05 J/cm{sup 3} and energy efficiency of 98.83%.

  14. The humidity in a Dräger Primus anesthesia workstation using low or high fresh gas flow and with or without a heat and moisture exchanger in pediatric patients.

    Science.gov (United States)

    Bicalho, Gustavo P; Braz, Leandro G; de Jesus, Larissa S B; Pedigone, Cesar M C; de Carvalho, Lídia R; Módolo, Norma S P; Braz, José R C

    2014-10-01

    An inhaled gas absolute humidity of 20 mg H2O·L is the value most considered as the threshold necessary for preventing the deleterious effects of dry gas on the epithelium of the airways during anesthesia. Because children have small minute ventilation, we hypothesized that the humidification of a circle breathing system is lower in children compared with adults. The Primus anesthesia workstation (Dräger Medical, Lübeck, Germany) has a built-in hotplate to heat the patient's exhaled gases. A heat and moisture exchanger (HME) is a device that can be used to further humidify and heat the inhaled gases during anesthesia. To evaluate the humidifying properties of this circle breathing system during pediatric anesthesia, we compared the temperature and humidity of inhaled gases under low or high fresh gas flow (FGF) conditions and with or without an HME. Forty children were randomly allocated into 4 groups according to the ventilation of their lungs by a circle breathing system in a Dräger Primus anesthesia workstation with low (1 L·min) or high (3 L·min) FGF without an HME (1L and 3L groups) or with an HME (Pall BB25FS, Pall Biomedical, East Hills, NY; HME1L and HME3L groups). The temperature and absolute humidity of inhaled gases were measured at 10, 20, 40, 60, and 80 minutes after connecting the patient to the breathing circuit. The mean inhaled gas temperature was higher in HME groups (HME1L: 30.3°C ± 1.1°C; HME3L: 29.3°C ± 1.2°C) compared with no-HME groups (1L: 27.0°C ± 1.2°C; 3L: 27.1°C ± 1.5°C; P humidity was higher in HME than no-HME groups and higher in low-flow than high-flow groups ([HME1L: 25 ± 1 mg H2O·L] > [HME3L: 23 ± 2 mg H2O·L] > [1L: 17 ± 1 mg H2O·L] > [3L: 14 ± 1 mg H2O·L]; P humidity level of the inhaled gases thought to reduce the risk of dehydration of airways. Insertion of an HME increases the humidity and temperature of the inhaled gases, bringing them closer to physiological values. The use of a low FGF enhances the

  15. How to introduce climate change into extreme precipitation predetermination? First attempts to tamper with the MEWP method.

    Science.gov (United States)

    Gérardin, Maxime; Brigode, Pierre; Bernardara, Pietro; Gailhard, Joël; Garçon, Rémy; Paquet, Emmanuel; Ribstein, Pierre

    2013-04-01

    The MEWP (Multi-Exponential Weather Pattern, Garavaglia et al. 2010) distribution is part of the operational method in use at EDF (Electricité de France) for computing dam spillways design floods, i.e. the magnitude of the flood that occurs at a given return period. The return periods of interest lie in the 100 - 10,000 years range. Relying on a purposely-designed classification of atmospheric circulations into weather patterns, and assigning a catchment-specific asymptotical coefficient to each of these patterns, the MEWP distribution provides the daily areal rainfall as a function of the return period. In its current state, the method relies on the implicit assumption of climate stationnarity. In this work we seek to introduce climate change into the MEWP framework. Since the MEWP distribution basically contains two sorts of parameters, namely frequencies of the weather patterns, and magnitudes of the events occurring within each of these patterns, we examine the plausible evolution of these two sets of parameters under climate change, and the sensitivity of the final result to these two sorts of changes. On the one hand, the future frequencies are assessed thanks to GCM outputs from CMIP5, and significant, albeit not greater than the internal variability, changes are observed. On the other hand, the future magnitudes can be suspected to follow the Clausius-Clapeyron relationship (e.g. Pall et al., 2007, and Lenderink et van Meijgaard, 2008). We assess the validity of this hypothesis on the observed daily areal precipitation series for more than a hundred catchments in France. The sensitivity analysis shows that, for the return periods at stake, the impact of frequency changes is small relative to that of magnitude changes, while this would not be true for smaller return periods. Therefore, we propose to incorporate climate change into the MEWP distribution in a simple but realistic way, by taking account of the magnitude change only. We conclude with some

  16. Total glucosides of paeony suppresses experimental autoimmune uveitis in association with inhibition of Th1 and Th2 cell function in mice.

    Science.gov (United States)

    Huang, Xue-Tao; Wang, Bin; Zhang, Wen-Hua; Peng, Man-Qiang; Lin, Ding

    2018-01-01

    Total glucosides of paeony (TGP) are active components extracted from the roots of Paeonia lactiflora Pall. In this study, we investigated the role and mechanisms of TGP in experimental autoimmune uveitis (EAU) model of mice. The C57BL/6 mice were randomly divided into three groups: sham group, EAU-control group, and EAU-TGP group. Clinical score of images of the eye fundus were taken on 7, 14, 21, and 28 days after induction of EAU. The concentrations of proinflammatory cytokines in intraocular fluid were measured at 14 days after EAU induction with the use of a multiplex assay system. Flow cytometry was used to analyze the frequency of CD4+, CD8+, interferon-gamma (IFN-γ), and CD4+/CD8+ ratio in spleen and lymph nodes. Western blotting was used to measure expressions of mitogen-activated protein kinase (MAPK) pathway-related proteins in retina. Clinical scores for uveitis were lower in TGP-treated EAU mice than those without TGP treatment. Importantly, the concentrations of cytokines induced by T-helper 1 (Th1) and T-helper 2 (Th2) cells in intraocular fluid were reduced in EAU mice treated with TGP. Furthermore, the frequency of CD4+, IFN-γ, and CD4+/CD8+ ratio was decreased and the frequency of CD8+ was increased in spleen and lymph nodes of mice treated with TGP. The anti-inflammatory effects of TGP were mediated by inhibiting the MAPK signaling pathways. Our results showed that TGP suppressed uveitis in mice via the inhibition of Th1 and Th2 cell function. Thus, TGP may be a promising therapeutic strategy for uveitis, as well as other ocular inflammatory diseases.

  17. Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain.

    Science.gov (United States)

    Mao, Qing-Qiu; Xian, Yan-Fang; Ip, Siu-Po; Tsai, Sam-Hip; Che, Chun-Tao

    2010-07-11

    The root part of Paeonia lactiflora Pall., commonly known as peony, is a commonly used Chinese herb for the treatment of depression-like disorders. Previous studies in our laboratory have showed that total glycosides of peony (TGP) produced antidepressant-like action in various mouse models of behavioral despair. The present study aimed to investigate the mechanism(s) underlying the antidepressant-like action of TGP by measuring neurotrophins including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in non-stressed and chronic unpredictable mild stress (CUMS)-treated rats. TGP (80 or 160 mg/kg/day) was administered by oral gavage to the animals for 5 weeks. The results showed that CUMS caused depression-like behavior in rats, as indicated by the significant decreases in sucrose consumption and locomotor activity (assessed by open-field test). In addition, it was found that BDNF contents in the hippocampus and frontal cortex were significantly decreased in CUMS-treated rats. CUMS treatment also significantly decreased the level of NGF in the frontal cortex of the animals. Daily intragastric administration of TGP (80 or 160 mg/kg/day) during the five weeks of CUMS significantly suppressed behavioral and biochemical changes induced by CUMS. Treating non-stressed animals with TGP (160 mg/kg) for 5 weeks also significantly increased BDNF contents in the hippocampus and frontal cortex, and NGF contents in the frontal cortex. The results suggest that the antidepressant-like action of TGP is mediated, at least in part, by increasing the expression of BDNF and NGF in selective brain tissues. Copyright 2010 Elsevier B.V. All rights reserved.

  18. Total glucosides of paeony regulates JAK2/STAT3 activation and macrophage proliferation in diabetic rat kidneys.

    Science.gov (United States)

    Wang, Kun; Wu, Yong-Gui; Su, Jing; Zhang, Jing-Jing; Zhang, Pei; Qi, Xiang-Ming

    2012-01-01

    Total glucosides of paeony (TGP) is the major active constituent of Paeonia lactiflora Pall., which has shown renoprotection in experimental diabetic nephropathy. Activation of Janus kinase/signal transducers and activators of transcription (JAK/STAT) is an important mechanism by which hyperglycemia contributes to renal damage. Macrophages also play an essential role in the pathogenesis of diabetic nephropathy. Herein, we investigated the ability of TGP to modulate JAK2/STAT3 activation and macrophage proliferation in rats with streptozotocin (STZ)-induced diabetes. TGP (50, 100, and 200 mg/kg) was administered orally once a day for eight weeks. Levels of p-JAK2 and p-STAT3 were determined by Western blot analysis. Immunohistochemistry and double immunohistochemistry were used to identify p-STAT3, ED-1, PCNA/ED-1, and p-STAT3/ED-1-positive (+) cells. The elevated 24-h urinary albumin excretion rate was markedly attenuated by treatment with 50, 100, and 200 mg/kg TGP. Western blot analysis showed that the significantly increased levels of p-JAK2, p-STAT3 proteins in the kidneys of diabetic rats were significantly inhibited by 50, 100, and 200 mg/kg TGP treatment. The marked accumulation and proliferation of macrophages in diabetic kidneys were significantly inhibited by TGP treatment. ED-1+/p-STAT3+ cells were significantly increased in the kidneys from the model group but were significantly inhibited by TGP treatment. These results show that TGP significantly inhibited diabetic nephropathy progression and suggest that these protective effects are associated with the ability of TGP to inhibit the JAK2/STAT3 pathway and macrophage proliferation and action.

  19. Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis.

    Science.gov (United States)

    Chen, Zhu; Li, Xiang-Pei; Li, Zhi-Jun; Xu, Liang; Li, Xiao-Mei

    2013-03-01

    Combination use of methotrexate (MTX) and leflunomide (LEF) has been proved effective in the treatment of active rheumatoid arthritis (RA). However, previous trials have documented that both are associated with increased incidence of liver toxicity. As active compounds extracted from the roots of the traditional Chinese herb Paeonia lactiflora Pall, total glucosides of paeony (TGP) have been shown to have anti-inflammatory, hepatoprotective and immuno-regulatory activities, without evident toxicity or side effects. In this 24-week, open label, randomized multicenter clinical trial, we investigated the efficacy of TGP and the protective effect on hepatotoxicity in the combination treatment with LEF and MTX for patients with active RA. A total of 204 patients with active RA (DAS28>3.2) recruited from 3 regional referral centers were enrolled and received MTX and LEF combination therapy (MTX 10 mg/week plus LEF 20 mg/day) with or without TGP for up to 24 weeks by randomization. Hepatotoxicity was defined as an increase of at least 1.5-fold the upper limits of normal (ULN) of alanine aminotransferase (ALT) or aspartate aminotransferase (AST). Significantly less frequent hepatotoxicity was observed in patients with TGP than those without (9.5% vs 34.8%, p 1.5 to ≤2 times and >2 to ≤3 times the ULN were lower in TGP group than the control (1.9% vs 10.1%, 2.9% vs 12.4%, p TGP group achieved a European League Against Rheumatism (EULAR) good response or moderate response at 12 weeks, although there is no statistical significance. Similar results were observed at 24 weeks. Our preliminary study demonstrates the hepatoprotective and additive role of TGP in combination with MTX and LEF in the treatment of active RA. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. Hepatoprotective effect of peony total glucosides and the underlying mechanisms in diabetic rats.

    Science.gov (United States)

    Xia, Ling-Ling; Zhu, Qi-Jin; Wu, Yong-Gui

    2017-12-01

    Total glucosides of peony (TGP), compounds extracted from the dried roots of Paeonia lactiflora Pall, have been reported to have anti-inflammatory and antioxidative activities. However, the protective effect of TGP on liver injury and the underlying mechanisms remains unknown in diabetic rats. Current study investigates prevention of liver injury by TGP in diabetic rats and its mechanism was related to the inhibition of endoplasmic reticulum stress (ERS). Fifty adult male rats were randomly divided into: Normal group, diabetic group, TGP (50, 100 and 200 mg/kg/day) treatment groups (n = 10 per group). At the end of the 8th week, the liver was removed for biochemical and histological examinations. Compared with the diabetic group, administration of TGP at doses of 50, 100 and 200 mg/kg significantly prevented the increase of hepatic fibrosis score (ED 50 139.4 mg/kg). Compared with diabetic group, TGP at doses of 50, 100 and 200 mg/kg showed an inhibition on the increased macrophage infiltration. MCP-1 and TNF-α mRNA and protein expression were significantly increased in diabetic group compared with normal group; TGP administration caused significant reduction of high levels of MCP-1 and TNF-α mRNA as well as protein levels. Also, TGP at all doses showed an inhibition on the increased GRP78 levels, p-Perk levels and p-Eif2α levels in liver from diabetic group. Our results indicate that TGP has potential as a treatment for diabetic liver injury attenuating liver lipid accumulation and inflammation as well as ERS induced by diabetic condition.

  1. The response of dark septate endophytes (DSE to heavy metals in pure culture.

    Directory of Open Access Journals (Sweden)

    Yihui Ban

    Full Text Available Dark septate endophytes (DSE occur widely in association with plants exposed to heavy metal stress. However, little is known about the response of DSE exposed to heavy metals. In this study, five DSE were isolated from the roots of Astragalus adsurgens Pall. seedlings growing on lead-zinc mine tailings in China. Based on morphological characteristics and DNA sequence analyses, the isolates were identified as Gaeumannomyces cylindrosporus, Paraphoma chrysanthemicola, Phialophora mustea, Exophiala salmonis, and Cladosporium cladosporioides. G. cylindrosporus was selected to explore responses to Pb stress. Scanning electron microscopic observations of G. cylindrosporus grown on solid medium revealed curling of hyphae and formation of hyphal coils in response to Pb. In contrast, in liquid medium, hyphae became thick and swollen with an increase in Pb (II concentration. We interpret that these changes are related to the variation in cell wall components. We also demonstrated that fungal melanin content increased with the addition of Pb(II. Melanin, as an important component in the cell wall, is known to be an essential antioxidant responsible for decreasing heavy metal toxicity. We also measured the total soluble protein content and glutathione (GSH concentrations in G. cylindrosporus and found that they initially increased and then decreased with the increase of Pb(II concentrations. The antioxidant enzyme activities were also examined, and the results showed that superoxide dismutase (SOD activity was significantly positively correlated with Pb(II concentrations (r = 0.957, P<0.001. Collectively, our observations indicate that the intracellular antioxidant systems, especially fungal melanin, play an important role in abating the hazards of heavy metals.

  2. Study On DPPH Free Radical - Scavenging Activity Of Antioxidant Compounds In Plants Composing BIN-5 Biological Active Preparation

    Directory of Open Access Journals (Sweden)

    Purevjav Urjintseren

    2015-08-01

    Full Text Available Recently there has been common trend among people to refuse from food and medications produced via synthetic method but try to consume natural products as much as possible instead. In this regard wild berries and medicinal plants are considered to be highly essential for human health as these kinds of plants serve as rich sources of biological active substances-phenol compounds. As a result of conducting research on source and spread of herbs which are commonly used as anti-diabetic medication we have developed a technological method to extract preparations from medicinal herbs such as Peony Paeonia lactiflora Pall Dandelion Taraxacum officinalis Wigg. Huckleberry Vaccinium myrtillus L Blueberry Vaccinium uliginosum L Cranberry Vaccinium vitisidaea L and Stinging nettles Urtica dioica accordingly studied chemical composition and antioxidant activity and conducted pharmacological study. With the use of Folin Denis amp Folin Ciocalteu reagent methodit was determined that the content of polyphenol compounds was 4.14-5.17 and 27.5 101.5mgml. The study was also aimed to investigate DPPH free radical-scavenging activity in connection with term temperature and concentration to identify the most rational technological procedure. As a result of study it was identified that free radical-scavenging activity of herbs selected for the study was generally estimated at 564.25-1750.00 mcgml whereas antioxidant activity of solvents with 2-10 mgml concentration was 417.20-1750.00 mcg ml respectively. This shows that such activity is dependent on concentration. However in temperature of 30 1000amp1057 degrees their activity has slowly been decreased by 1750 mcgml 476.7mcgml depending on temperature. Regarding the stinging nettles the activity was grown directly dependent from temperature. DPHH free radical-scavenging activity was gradually increased in 1-10 minutes but was relatively stable and active in 11-16 minutes.

  3. Preliminary field evaluation of high efficiency steel filters

    Energy Technology Data Exchange (ETDEWEB)

    Bergman, W.; Larsen, G.; Lopez, R. [Lawrence Livermore National Laboratory, CA (United States)] [and others

    1995-02-01

    We have conducted an evaluation of two high efficiency steel filters in the exhaust of an uranium oxide grit blaster at the Y-12 Plant in Oak Ridge Tennessee. The filters were installed in a specially designed filter housing with a reverse air-pulse cleaning system for automatically cleaning the filters in-place. Previous tests conducted on the same filters and housing at LLNL under controlled conditions using Arizona road dust showed good cleanability with reverse air pulses. Two high efficiency steel filters, containing 64 pleated cartridge elements housed in the standard 2` x 2` x 1` HEPA frame, were evaluated in the filter test housing using a 1,000 cfm slip stream containing a high concentration of depleted uranium oxide dust. One filter had the pleated cartridges manufactured to our specifications by the Pall Corporation and the other by Memtec Corporation. Test results showed both filters had a rapid increase in pressure drop with time, and reverse air pulses could not decrease the pressure drop. We suspected moisture accumulation in the filters was the problem since there were heavy rains during the evaluations, and the pressure drop of the Memtec filter decreased dramatically after passing clean, dry air through the filter and after the filter sat idle for one week. Subsequent laboratory tests on a single filter cartridge confirmed that water accumulation in the filter was responsible for the increase in filter pressure drop and the inability to lower the pressure drop by reverse air pulses. No effort was made to identify the source of the water accumulation and correct the problem because the available funds were exhausted.

  4. Development of "ultrasound-assisted dynamic extraction" and its combination with CCC and CPC for simultaneous extraction and isolation of phytochemicals.

    Science.gov (United States)

    Zhang, Yuchi; Liu, Chunming; Li, Jing; Qi, Yanjuan; Li, Yuchun; Li, Sainan

    2015-09-01

    A new method for the extraction of medicinal herbs termed ultrasonic-assisted dynamic extraction (UADE) was designed and evaluated. This technique was coupled with counter-current chromatography (CCC) and centrifugal partition chromatography (CPC) and then applied to the continuous extraction and online isolation of chemical constituents from Paeonia lactiflora Pall (white peony) roots. The mechanical parameters, including the pitch and diameter of the shaft, were optimized by means of mathematical modeling. Furthermore, the configuration and mechanism of online UADE coupled with CCC and CPC were elaborated. The stationary phases of the two-phase solvent systems from CCC and CPC were utilized as the UADE solution. The extraction solution was pumped into the sample loop and then introduced into the CCC column; the target compounds were eluted with the lower aqueous phase of the two-phase solvent system. During the CCC separation, the extraction solution was continuously fed in the sample loop by turning the ten-port valve; the extraction solution was then pumped into the CPC column and eluted by the mobile phase of the two-phase solvent system mentioned above. When the first cycle of the UADE/CCC/CPC was completed, the second cycle experiment could be carried out, and so on. Four target compounds (albiflorin, benzoylpaeoniflorin, paeoniflorin, and galloylpaeoniflorin) with purities above 94.96% were successfully extracted and isolated online using the two-phase solvent system comprising ethyl acetate-n-butanol-ethanol-water (1:3.5:2:4.5, v/v/v/v). Compared with conventional extraction methods, the instrumental setup of the present method offers the advantages of automation and systematic extraction and isolation of natural products. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

  5. Actitud del estudiante de ingeniería hacia sus errores en el aprendizaje de la matemática

    Directory of Open Access Journals (Sweden)

    Lissette Franchi Boscán

    2011-09-01

    Full Text Available Bajo cualquier esquema de enseñanza-aprendizaje de la matemática, cuando al alumno se le señalan errores en su trabajo, puede, en general, adoptar tres tipos de actitud: una actitud negativa, bajo la cual el alumno considera que sus errores son sencillamente un síntoma de su fracaso; una actitud neutra o indiferente ante sus errores; o una actitud positiva, considerándolos como un medio para aprender y planteándose como reto el superarlos. Este artículo muestra una investigación que abordó el estudio de actitudes vinculadas al proceso de aprendizaje de la matemática. Su objetivo fue describir la actitud que el estudiante de ingeniería de la Uni- versidad del Zulia exhibe frente a sus errores cuando aprende matemática. La sus tentación teórica se baso en Brousseau (2001, Briñol et al. (2007 y los autores Pallí y Martínez (2004. Se utilizó una escala AEAM (Actitud hacia el Error del Alumno de Matemática, tipo Likert con 6 alternativas de respuesta que consta de 36 ítems, en su segunda versión, actualizada por los autores. El instrumento fue validado mediante juicio de expertos y se determinó que era de alta confiabilidad, con un alpha de Cronbach de 0.9073. Se concluyó que los participantes, en su mayoría, mostraron una actitud moderadamente positiva hacia sus errores, que al no estar ubicada en el extremo positivo deseable refleja una actitud débil que no garantiza una conducta adecuada hacia los errores, pero que sin embargo es sus ceptible de ser mejorada hacia una actitud francamente positiva.

  6. Invasive Ponto-Caspian hydrozoan Cordylophora caspia (hydrozoa: Cnidaria) in southern Baltic coastal lakes

    Science.gov (United States)

    Obolewski, Krystian; Jarosiewicz, Anna; Ożgo, Małgorzata

    2015-12-01

    Cordylophora caspia Pall. is a highly invasive Ponto-Caspian colonial hydroid with a worldwide distribution. It is a biofouling organism colonizing industrial water installations and causing serious economic problems. Here, we give the first report of its occurrence in southern Baltic coastal lakes, and analyze its distribution in relation to environmental factors and likely colonization routes. Samples were collected from the stalks of Phragmites australis at the total of 102 sites in 15 lakes and lagoons. The species was most numerous in lagoons, i.e. ß-oligohaline water bodies with a surface hydrological connection with the sea, where it reached mean densities of 1200-4800 hydranths m-2. In regression tree analysis, chloride concentration, followed by pH, were the strongest explanatory variables for its occurrence, with highest densities observed at chloride concentration above 1.18 g Cl L-1 and pH 8.05-9.26. At pH 5.77-8.04 higher densities were observed at temperatures above 20.3 °C. Generally, within the range of parameters observed in our study, high densities of C. caspia were associated with high chloride concentration, pH, temperature and electrical conductivity values. The species was also present in freshwater lakes; these colonies may have the highest capacity for future invasions of such habitats. Within lakes, high densities were observed at canals connecting these water bodies with the sea, and at sites close to the inflow of rivers. This distribution pattern can facilitate its further spread into inland waters.

  7. Drinking water decontamination by biological denitrification using fresh bamboo as inoculum source.

    Science.gov (United States)

    Bucco, Samuel; Padoin, Natan; Netto, Willibaldo Schmidell; Soares, Hugo Moreira

    2014-10-01

    Groundwater contamination is becoming a serious problem in many Brazilian regions. European countries started to deal with this issue in the 1980s, mainly caused by the extensive usage of nitrogenous fertilizers and the absence of domestic wastewater treatment. Due to its high solubility, nitrate readily passes through the soil and reaches the aquifer. Thereafter, this ion moves, following groundwater flow, and can be found several kilometers from the area where the pollution occurred. Concern about nitrate contamination is due to the link found between this contaminant and various human health diseases, such as methemoglobin and cancer. Studies carried out in France enabled the design and implementation of several biological denitrification plants throughout the country, in order to remove nitrate from its contaminated groundwater. Heterotrophic denitrification facilities shown to be adequate to treat high water flows with satisfactory nitrate removal efficiency, especially when static media supports are employed. The objective of this research was to evaluate the existence of denitrifying microorganisms in bamboo (Bambusa tuldóides) and verify the feasibility of their use to inoculate a pilot-scale fixed-bed bioreactor. The support material selected to fill the bioreactor bed was commercial polypropylene Pall rings, since such support has a high porosity associated with a wide superficial area. The bioreactor was able to produce and retain a large amount of cells. Using ethanol as carbon source, nitrate (N-NO3(-)) removal efficiency of the bioreactor stood around 80 % for a maximum nitrogen loading rate of approximately 6.5 mg N-NO3 (-) L(-1) h(-1).

  8. Palladium/Copper Alloy Composite Membranes for High Temperature Hydrogen Separation

    Energy Technology Data Exchange (ETDEWEB)

    J. Douglas Way; Paul M. Thoen

    2006-08-31

    This report summarizes progress made during the a three year University Coal Research grant (DEFG26-03NT41792) at the Colorado School of Mines. The period of performance was September 1, 2003 through August of 2006. We made excellent progress toward our goal of contributing to the development of high productivity, sulfur tolerant composite metal membranes for hydrogen production and membrane reactors. Composite Pd and Pd alloy metal membranes with thin metal films (1-7 {micro}m) were prepared on porous stainless steel and ceramic supports that meet or exceed the DOE 2010 and 2015 pure hydrogen flux targets at differential pressure of only 20 psi. For example, a 2 {micro}m pure Pd membrane on a Pall AccuSep{reg_sign} substrate achieved an ideal H{sub 2}/N{sub 2} separation factor of over 6000, with a pure hydrogen flux of 210 SCFH/ft{sup 2} at only 20 psig feed pressure. Similar performance was achieved with a Pd{sub 80}Au{sub 20} composite membrane on a similar stainless steel substrate. Extrapolating the pure hydrogen flux of this PdAu membrane to the DOE Fossil Energy target conditions of 150 psia feed pressure and 50 psia permeate pressure gives a value of 508 SCFH/ft{sup 2}, exceeding the 2015 target. At these thicknesses, it is the support cost that will dominate the cost of a large scale module. In a direct comparison of FCC phase PdCu and PdAu alloys on identical supports, we showed that a Pd{sub 85}Au{sub 15} (mass %) alloy membrane is not inhibited by CO, CO{sub 2}, or steam present in a water-gas shift feed mixture at 400 C, has better resistance to sulfur than a Pd{sub 94}Cu{sub 6} membrane, and has over twice the hydrogen permeance.

  9. Surface properties and physiology of Ulmus laevis and U. minor samaras: implications for seed development and dispersal.

    Science.gov (United States)

    Guzmán-Delgado, Paula; Fernández, Victoria; Venturas, Martin; Rodríguez-Calcerrada, Jesús; Gil, Luis

    2017-06-01

    Plant surface properties influence solid-liquid interactions and matter exchange between the organs and their surrounding environment. In the case of fruits, surface processes may be of relevance for seed production and dispersal. To gain insight into the relationship between surface structure, chemical composition and function of aerial reproductive organs, we performed diverse experiments with the dry, winged fruits, or samaras, of Ulmus laevis Pall. and Ulmus minor Mill. both at the time of full maturity (green samaras) and of samara dispersal (dry samaras). Samaras of both elm species showed positive photosynthetic rates and absorbed water through their epidermal surfaces. The surface wettability, free energy, polarity and solubility parameter were lower in U. laevis than in U. minor and decreased for dry samaras in both species. Ulmus laevis samaras had a high degree of surface nano-roughness mainly conferred by cell wall folds containing pectins that substantially increased after hydration. The samaras in this species also had a thicker cuticle that could be isolated by enzymatic digestion, whereas that of U. minor samaras had higher amounts of soluble lipids. Dry samaras of U. laevis had higher floatability and lower air sustentation than those of U. minor. We concluded that samaras contribute to seed development by participating in carbon and water exchange. This may be especially important for U. minor, whose samaras develop before leaf emergence. The trichomes present along U. laevis samara margin may enhance water absorption and samara floatability even in turbulent waters. In general, U. minor samaras show traits that are consistent with a more drought tolerant character than U. laevis samaras, in line with the resources available both at the tree and ecosystem level for these species. Samara features may additionally reflect different adaptive strategies for seed dispersal and niche differentiation between species, by favoring hydrochory for U. laevis

  10. K+ and Na+ fluxes in roots of two Chinese Iris populations

    Directory of Open Access Journals (Sweden)

    Pinfang LI,Biao ZHANG

    2014-06-01

    Full Text Available Maintenance of ion homeostasis, particularly the regulation of K+ and Na+ uptake, is important for all plants to adapt to salinity. Observations on ionic response to salinity and net fluxes of K+, Na+ in the root exhibited by plants during salt stress have highlighted the need for further investigation. The objectives of this study were to compare salt adaptation of two Chinese Iris (Iris lactea Pall. var. chinensis (Fisch. Koidz. populations, and to improve understanding of adaptation to salinity exhibited by plants. Plants used in this study were grown from seeds collected in the Xinjiang Uygur Autonomous Region (Xj and Beijing Municipality (Bj, China. Hydroponically-grown seedlings of the two populations were supplied with nutrient solutions containing 0.1 (control and 140 mmol·L-1 NaCl. After 12 days, plants were harvested for determination of relative growth rate and K+, Na+ concentrations. Net fluxes of K+, Na+ from the apex and along the root axis to 10.8 mm were measured using non-invasive micro-test technique. With 140 mmol·L-1 NaCl treatment, shoots for population Xj had larger relative growth rate and higher K+ concentration than shoots for population Bj. However, the Na+ concentrations in both shoots and roots were lower for Xj than those for Bj. There was a lower net efflux of K+ found in population Xj than by Bj in the mature zone (approximately 2.4-10.8 mm from root tip. However, no difference in the efflux of Na+ between the populations was obtained. Population Xj of I. lactea continued to grow normally under NaCl stress, and maintained a higher K+/Na+ ratio in the shoots. These traits, which were associated with lower K+ leakage, help population Xj adapt to saline environments.

  11. [Gallstone disease during pregnancy at Landspitali University Hospital 1990-2010].

    Science.gov (United States)

    Kolbeinsson, Hordur Mar; Hardardottir, Hildur; Birgisson, Gudjon; Moller, Pall Helgi

    2016-01-01

    Gallstone disease in pregnant patients and their management in Iceland has not been studied. Management of these patients changed after the introduction of laparoscopic cholecystectomy. The aim of this study was to investigate the incidence, symptoms, diagnostic methods and management of gallstone disease during pregnancy at the National University Hospital of Iceland during the years 1990-2010. This was a retrospective study and included all pregnant women admitted with gallstone diseases to the National University Hospital of Iceland which is the only tertiary hospital in Iceland. Information regarding age, symptoms and diagnostic methods for all women with gallstone disease along with BMI, ASA scores, pathology results and pregnancy related outcomes for women who underwent cholecystectomy were gathered. During the twenty year time period 77 women were admitted with gallstone disease in 139 admissions which makes incidence 0,1% amongst pregnant women. Diagnoses incuded biliary colic (n=59), common bile duct stones (n=10), acute cholecystitis (n=7) and gallstone pancreatitis (n=1). The most common symptom was RUQ pain (n=63). Two preterm births were a direct consequence of gallstone disease. Fifteen women underwent cholecystectomy during pregnancy and 17 during the six week period after birth. Mean BMI was 31,1 and median ASA score was 1. Pathology reports showed chronic inflammation (n=24) and acute inflammation (n=5), one case included gallstones without inflammation Adverse outcomes of surgeries were two cases of gallstones left in the common bile duct. No stillbirths or preterm births resulted from cholecystectomies during pregnancy. Gallstone disease during pregnancy is rare and readmissions are frequent. Pregnancy related complications are rare. Laparoscopic cholecystectomy is safe during pregnancy. Key words: gallstones, pregnancy, laparoscopic cholecystectomy. Correspondence: Pall Helgi Moller pallm@landspitali.is.

  12. The phenology of flowering and fluctuations of airborne pollen concentrations of selected trees in Poznań, 2003-2004

    Directory of Open Access Journals (Sweden)

    Alicja Stach

    2012-12-01

    Full Text Available The aim of the study was to describe the relationships between the flowering phase of selected tree species, whose pollen is known to be allergenic, and fluctuations in the pollen in the air, and to use results obtained for making allergological forecasts. Studies were conducted of five tree taxa: Populus, Ulmus, Salix, Aesculus, and Tilia, in the years 2003-2004. Aeropalinological analyses concerned the above mentioned genera, while in phenological studies specific species were investigated, i.e. the most common representatives of a given genus found in Poland, that is Populus wilsonii, Ulmus laevis Pall. C. K.Schneid., Salix caprea L., Aesculus hippocastanum L. and Tilia cordata Mill. Aerobiological monitoring was performed using a the volumetric method and phenological observations of flowering phases were made according to the Łukasiewicz method. While observing the emergence of individual phenological symptoms and measurements of the concentration of pollen of the investigated taxa in the air of Poznań, a distinct acceleration was observed in 2004, a year that was characterized by a milder winter. This applied not only to the species blooming in early spring, but also to the later ones. Pollen grains of the investigated taxa, except for Aesculus, appeared earlier in aeropalinological observations than the macroscopically observed beginning of flowering in selected trees. Apart from a poplar, the end of flowering in the other trees occurred each year earlier than would follow from the aerobiological observations. This may be explained by the abundance of species within a taxon, and the effect of medium - and long-distance transport.

  13. The effect of natural and planted forest stands on soil fertility in the Hyrcanian region, Iran

    Directory of Open Access Journals (Sweden)

    RAZIYEH RAFEIE JAHED

    2014-10-01

    Full Text Available Rafeie Jahed R, Hosseini SM, Kooch Y. 2014. The effect of natural and planted forest stands on soil fertility in the Hyrcanian region, Iran. Biodiversitas 15: 206-214. In the present work, we studied the effect of natural and planted forest stands on soil fertility in the Hyrcanian region of northern Iran. Natural forest stands (including Acer velutinum Bioss., Zelkova carpinifolia (Pall, Parrotia persica (DC. C.A.Mey, Quercus castaneifolia C.A. Mey., Carpinus betulus L, Mixed planted stand (including Acer velutinum, Ulmus carpinifolia G. Suckow Quercus castaneifolia C.A. Mey, Carpinus betulus L., Tilia begonifolia Scop. Subsp. caucasia (Rupr. Loria; maple (Acer velutinum Bioss plantation, pine (Pinus taeda L. plantation and also clear-cut region (control were considered in this research. Soil samples were collected at two different depths, i.e., 0-15 and 15-30 cm, and characterized with respect to organic carbon (C, total nitrogen (N, available nutrient elements (P, K, Ca and Mg; pH and soil texture. The results showed that the highest amount of total N was found in mixed plantation. The highest amount of available P was detected in maple plantation and pine plantation had the highest available K and organic C than other treatments. The highest and the lowest available Ca and Mg were found in natural forest and control area, respectively. In addition, it was observed that nutrients accumulate in upper layers of the soil. Hardwood stands have been more successful than the conifers stands, so this should be considered in the sustainable management of forests.

  14. Trends in market share of leading cigarette brands in the USA: national survey on drug use and health 2002-2013.

    Science.gov (United States)

    Sharma, Anushree; Fix, Brian V; Delnevo, Cristine; Cummings, K Michael; O'Connor, Richard J

    2016-01-29

    The main objective of this study is to examine trends in market share for leading cigarette brands, both before (2002-2008) and after (2009-2013) Food and Drug Administration (FDA) regulation of tobacco products.Design Data come from the annual National Survey on Drug Use and Health from 2002 through 2013. Descriptive statistics, cross tabulations, and logistic regression were employed. Data were weighted to the US population and adjusted for cigarette consumption. Our analysis is restricted to 164,343 current cigarette smokers who were at least 12 years of age or older, had smoked at least one cigarette in the 30 days prior to the survey, and reported a usual cigarette brand at the time of the survey. Over 12 years, 14 brands comprised over 77% of the cigarette market. Marlboro consistently held over 38% of the market. Newport held the second highest market share, and increased from 7.2% in 2002 to 10.9% by 2013. Market share of Pall Mall grew by over 400% (1.7% in 2002 vs 8.9% in 2013), likely aided by the 2009 Federal excise tax increase. No clear associations of changes in market share with the implementation of FDA's regulatory authority over tobacco in 2009 were noted. Tracking market share trends offers clues about brand marketing changing preferences of consumers. Rapidly growing cigarette brands should be monitored to determine if specific marketing practices or design changes are drivers, as these could represent public health concerns. Monitoring trends in cigarette market share could inform regulatory decision-making efforts related to marketing and advertising. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  15. Микроэлементный состав лекарственных растений Приморского края

    OpenAIRE

    ИВАНЕНКО НАТАЛЬЯ ВЛАДИМИРОВНА; КОВЕКОВДОВА Л.Т.

    2014-01-01

    Исследован элементный состав (Fe, Al, Mn, Cu, Zn, Ba, Ni, Pb, Cd, As, Se) высших наземных растений Приморского края, произрастающих на территории Спасского района: шиповник даурский (Rosa davurica Pall.), лимонник китайский (Shizandra chinensis (Turcz.) Baill), элеутерококк колючий (Eleutherococcus senticosus Maxim.), чистотел азиатский (Chelidonium asiaticum (H. Hara) Krahulc.), подорожник азиатский (Plantago asiatica L.), в состав которых входят вещества, обладающие фармакологической активн...

  16. Антистрессорное действие дальневосточных растений

    OpenAIRE

    ЧЕРНЯК ДАРЬЯ МИХАЙЛОВНА; ТИТОВА М.С.

    2014-01-01

    В результате 5-летних экспериментальных исследований извлечений более чем из 200 видов растений Дальнего Востока установлено, что наибольшей антистрессорной активностью обладают бадан тихоокеанский (Bergenia pacifica Kom.), борец вьющийся (Aconitum volubile Pall.), орех маньчжурский (Juglans mandshurica Maxim.), лимонник китайский (Schisandra chinensis Turcz.), леспедеца двухцветная (Lespedeza bicolor Turcz.), элеутерококк колючий (Eleutherococcus senticosus Maxim.), виноград амурский (Vitis ...

  17. Separation of Fischer-Tropsch Wax Products from Ultrafine Iron Catalyst Particles

    Energy Technology Data Exchange (ETDEWEB)

    James K. Neathery; Gary Jacobs; Amitava Sarkar; Burtron H. Davis

    2005-09-30

    In this reporting period, a study of ultra-fine iron catalyst filtration was initiated to study the behavior of ultra-fine particles during the separation of Fischer-Tropsch Synthesis (FTS) liquids filtration. The overall focus of the program is with slurry-phase FTS in slurry bubble column reactor systems. Hydrocarbon products must be separated from catalyst particles before being removed from the reactor system. An efficient wax product/catalyst separation system is a key factor for optimizing operating costs for iron-based slurry-phase FTS. Previous work has focused on catalyst particle attrition and the formation of ultra-fine iron carbide and/or carbon particles. With the current study, we are investigating how the filtration properties are affected by these chemical and physical changes of the catalyst slurry during activation/synthesis. The change of particle size during the slurry-phase FTS has monitored by withdrawing catalyst sample at different TOS. The measurement of dimension of the HRTEM images of samples showed a tremendous growth of the particles. Carbon rims of thickness 3-6 nm around the particles were observed. This growth in particle size was not due to carbon deposition on the catalyst. A conceptual design and operating philosophy was developed for an integrated wax filtration system for a 4 liter slurry bubble column reactor to be used in Phase II of this research program. The system will utilize a primary inertial hydroclone followed by a Pall Accusep cross-flow membrane. Provisions for cleaned permeate back-pulsing will be included to as a flux maintenance measure.

  18. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    1971-04-01

    Full Text Available - A.H.N. Verwey, A.J. Bernet Kempers, Borobudur: Mysteriegebeuren in steen, Verval en restauratie, Oudjavaans volksleven. Servire, Wassenaar 1970. 224 blz., 280 afb. - Graham W. Irwin, Anthony Reid, The contest for North Sumatra. Atjeh, the Netherlands and Britain 1858-1898. Kuala Lumpur and London: University of Malaya Press and Oxford University Press, 1969. 333 p., 8 plates, maps. - John Bastin, Fernand Mendes Pinto, The voyages and adventures of Fernand Mendez Pinto: Translated into English by H. Cogan 1635. Dawsons of Pall Mall. The Colonial History Series, General Editor, D.H. Simpson. London, 1969. Pages xiv + 318. - R. Roolvink, Yahya Ismail, Satu kajian mengenai karya2 Ahmad Talu. Dewan Bahasa dan Pustaka, Kuala Lumpur, 1970. XIV + 82 pp. - Harry Aveling, Umar Junus, Perkembangan puisi Melayu moden. Dewan Bahasa dan Pustaka, Kuala Lumpur 1970. XIV + 161 pp. - A.F. Ros, Clifford Geertz, Islam observed: Religious development in Morocco and Indonesia. Yale University Press, New Haven and London 1968. XII en 136 blz. - Go Gien Tjwan, Joseph-John Nevadomsky, The Chinese in Southeast Asia. A selected and annotated bibliography of publications in Western languages 1960-1970. Occasional Paper No. 6 of the Center for South and Southeast Asia Studies, University of California, Berkeley, California, 1970, 119 p., Alice Li (eds. - F.G. Bailey, S. Arasaratnam, Indians in Malaysia and Singapore. Oxford University Press for Institute of Race Relations, London 1970. 241 pp. - A.F. Marks, G.J. Kruijer, Cuba; Voorbeeld en uitdaging. Polak en Van Gennep, Amsterdam, 1968. 146 bladzijden; met foto’s. - ,

  19. El trasvase Júcar-Vinalopó. Una respuesta a la sobreexplotación de acuíferos

    Directory of Open Access Journals (Sweden)

    Mª Inmaculada López Ortiz

    2010-01-01

    Full Text Available El sistema Vinalopó-Alacantí en la provincia de Alicante es un espacio caracterizado por la escasez de recursos hídricos y por un gran desarrollo de las aguas subterráneas. Estas aguas han permitido el abastecimiento de buena parte de los municipios de la provincia y de una agricultura muy avanzada, caracterizada por su eficiencia y productividad. Con el objeto de paliar los graves problemas de sobreexplotación de las aguas subterráneas y restituir el equilibrio hídrico, el Plan Hidrológico de la cuenca del Júcar de 1988 previó la realización de un trasvase desde el Júcar al Vinalopó, éste fue aprobado por unanimidad y fue declarado de interés general por el Estado y sus obras se incluyeron en el Plan Hidrológico Nacional de 2001. La obra del trasvase se inició en 2002, con toma en Cortes de Pallás. En 2005, cuando se había ejecutado más del 52% del presupuesto el Ministerio de Medio Ambiente, de forma unilateral, decidió el cambio de toma y trazado, lo cual tendrá repercusiones sobre la disponibilidad de caudales, la calidad del agua trasvasada, los costes de construcción y explotación, la financiación tanto de la UE como de los particulares, y en los plazos de ejecución y puesta en servicio de la infraestructura. Esta decisión ha despertado una fuerte oposición en los potenciales usuarios, agrupados en la Junta Central de Usuarios del Vinalopó, Alacantí y Consorcio de Aguas de la Marina Baja (JCU.

  20. Comparison of two leukocyte reduction filters for whole blood derived platelets.

    Science.gov (United States)

    Cho, Jin-Hee; Choi, Ju Hee; Hur, Mina; Moon, Hee-Won; Park, Chul Min; Yun, Yeo-Min

    2012-08-01

    Leukocyte reduction filters are widely used for platelet transfusion therapy, and effective leukocyte removal is mandatory for transfusion safety. We evaluated both the performance of leukocyte reduction filters for platelets and the effect of filtration on platelet function. A total of 100 pooled products (eight platelet concentrates were randomly pooled for each product) were used in this study: 50 were filtered by BioP-plus (Fresenius Kabi AG, Homburg, Germany) and 50 by PXL-8 (Pall Corporation, East Hills, NY, USA). Leukocyte reduction, platelet recovery, and filtration time were evaluated in each leukocyte reduction filter. Platelet aggregation responses to thrombin receptor activation peptide stimulation were compared in pre- and post-filtration products using impedance aggregometry (Multiplate Analyzer, Dynabyte Medical, Munich, Germany). Leukocyte counts were uniformly less than 8.3×10(5) in all the post-filtration products, except one filtered by the PXL-8. Leukocyte reduction was 99.1% for BioP-plus and 99.7% for PXL-8, and platelet recovery was 84.2% for the BioP-plus and 86.7% for PXL-8. Filtration time of the BioP-plus was significantly shorter than that of PXL-8. Post-filtration platelet aggregation tended to decrease in both filters, showing no difference between them. Both BioP-plus and PXL-8 leukocyte reduction filters for platelets performed well with effective leukocyte reduction and satisfactory platelet recovery. Although platelet function was decreased after filtration procedures, its clinical relevance is uncertain. Copyright © 2012 Elsevier Ltd. All rights reserved.