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Sample records for bk post trasplante

  1. Diagnóstico y clasificación molecular del virus BK en receptores de trasplante renal

    OpenAIRE

    Riva, Omar; Cobos, Marisa; Clemente, J

    2010-01-01

    La infección primaria por virus BK ocurre durante la infancia permaneciendo latente en el tracto urogenital. En individuos que presentan alteraciones en la inmunidad celular, el virus se reactiva haciendo posible su detección en orina y sangre. En receptores de trasplante renal, la nefropatía producida por el virus BK puede llevar a la pérdida de la función del injerto. El virus BK es miembro de la familia Polyomaviridae, presenta un genoma de ADN circular doble cadena unido en forma covalent...

  2. Factores asociados y consecuencias clínicas de la anemia post trasplante renal

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    Mónica Freiberg

    2013-04-01

    Full Text Available Un porcentaje considerable de pacientes presentan anemia post trasplante renal. Su origen es multifactorial y sus principales etiologías dependen de la etapa post trasplante que se considere. Estudiamos en un grupo de 134 pacientes los factores asociados con anemia tardía (6 meses post trasplante y sus implicaciones clínicas a mediano plazo. En el análisis de regresión múltiple, la duración de la oliguria post trasplante y el número de episodios de rechazo fueron las variables significativamente asociadas con esta complicación. La supervivencia del órgano mostró una diferencia significativa a los 36 meses entre los grupos (83% en los anémicos versus 96% de los no anémicos p < 0.01. No observamos diferencias en mortalidad o eventos cardiovasculares. Concluimos que la presencia de anemia al sexto mes post trasplante renal está independiente y significativamente asociada con factores que condicionan la masa renal funcionante que explicarían además la menor supervivencia del injerto renal observada en estos pacientes.

  3. Association of renal adenocarcinoma and BK virus nephropathy post transplantation.

    Science.gov (United States)

    Kausman, Joshua Yehuda; Somers, Gino Rene; Francis, David Michael; Jones, Colin Lindsay

    2004-04-01

    While most BK virus infections are asymptomatic, immunosuppression has been associated with BK virus reactivation and impaired graft function or ureteric ulceration in renal transplant patients and hemorrhagic cystitis in bone marrow transplant patients. Oncogenicity is also postulated and this is the first report of a child with a carcinoma of the donor renal pelvis following BK virus allograft nephropathy. Removal of the primary tumor and cessation of immunosuppression led to regression of secondary tumors and a return to health. PMID:14986088

  4. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible

    OpenAIRE

    E. Bulliorsky; C. Shanley; G. Stemmelin; J. Ceresetto; O. Rabinovich

    2002-01-01

    El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH) con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoy...

  5. Trasplante pulmonar

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    M. Espinosa

    2006-08-01

    Full Text Available El transplante pulmonar suele ser la última opción terapéutica para pacientes con insuficiencia respiratoria. A pesar de los muchos avances en inmunología y el manejo de las complicaciones, la mortalidad y morbilidad asociadas a este trasplante son muy superiores a los demás. El rechazo agudo es casi un problema universal en el primer año, mientras que la bronquiolitis obliterante limita la supervivencia a largo plazo. Las infecciones respiratorias también cumplen un papel importante en las complicaciones asociadas al trasplante pulmonar por la constante exposición del injerto al medio exterior. No obstante, los éxitos de esta opción terapéutica que depende fundamentalmente de una correcta selección de donante y receptor, son evidentes, sobre todo en cuanto a calidad de vida se refiere.

  6. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible

    Directory of Open Access Journals (Sweden)

    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.

  7. Trasplante cardiaco

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    Donato Salas-Segura

    2008-12-01

    Full Text Available La insuficiencia cardiaca es un cuadro clínico frecuente y de apreciable mortalidad. A menudo de nuestra área de atracción emergen cardiópatas con diferentes grados de discapacidad, dependientes de familiares para su atención y que requieren re-hospitalizaciones y tratamientos costosos y a pesar de ello con mal pronóstico. Las autoridades sanitarias y particularmente el estado invierten anualmente mucho dinero en el tratamiento de los enfermos que la padecen y también en la cobertura de incapacidades para estos individuos. El trasplante cardiaco se ha implementado en el mundo como una excelente opción de tratamiento de los pacientes con insuficiencia cardiaca, capaz de brindar al menos 10 años de vida a pesar de lo riguroso del seguimiento, tanto para el paciente y su familia, como para el personal medico. El Hospital R. A. Calderón Guardia inició hace un año un Programa de Trasplante Cardiaco, presentamos aquí los 2 primeros pacientes y su seguimiento.

  8. S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK channels

    Directory of Open Access Journals (Sweden)

    MichaelJShipston

    2014-08-01

    Full Text Available Mechanisms that control surface expression and/or activity of large conductance calcium-activated potassium (BK channels are important determinants of their (pathophysiological function. Indeed, BK channel dysfunction is associated with major human disorders ranging from epilepsy to hypertension and obesity. S-acylation (S-palmitoylation represents a major reversible, post-translational modification controlling the properties and function of many proteins including ion channels. Recent evidence reveals that both pore-forming and regulatory subunits of BK channels are S-acylated and control channel trafficking and regulation by AGC-family protein kinases. The pore-forming α-subunit is S-acylated at two distinct sites within the N- and C-terminus, each site being regulated by different palmitoyl acyl transferases (zDHHCs and acyl thioesterases. (APTs. S-acylation of the N-terminus controls channel trafficking and surface expression whereas S-acylation of the C-terminal domain determines regulation of channel activity by AGC-family protein kinases. S-acylation of the regulatory β4-subunit controls ER exit and surface expression of BK channels but does not affect ion channel kinetics at the plasma membrane. Furthermore, a significant number of previously identified BK-channel interacting proteins have been shown, or are predicted to be, S-acylated. Thus, the BK channel multi-molecular signalling complex may be dynamically regulated by this fundamental post-translational modification and thus S-acylation likely represents an important determinant of BK channel physiology in health and disease.

  9. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible Pure red cell aplasia after ABO incompatible bone marrow transplantation

    OpenAIRE

    E. Bulliorsky; C. Shanley; G. Stemmelin; J. Ceresetto; O. Rabinovich

    2002-01-01

    El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH) con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoy...

  10. al trasplante de órganos

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    María Ángeles Pérez San Gregorio

    2005-01-01

    Full Text Available El trasplante de órganos es una alternativa terapéutica para aquellos pacientes que tienen problemas graves en el funcionamiento de un órgano vital: corazón, hígado, pulmón, etc. Dada la relevancia de este tema, en el presente estudio teórico analizamos los principales problemas psicológicos asociados al trasplante de órganos. Concretamente, hemos tenido en cuenta los siguientes apartados: 1 Repercusiones psicológicas del trasplante de órganos en los pacientes: delirium, trastornos sexuales, trastornos del estado de ánimo, trastornos de ansiedad, fantasías sobre el donante, insatisfacción con la imagen corporal y otros trastornos; 2 variables psicosociales que influyen en las repercusiones psicológicas asociadas al trasplante de órganos: apoyo familiar, trastornos psicológicos en los familiares, hospitalización, expectativas pre y post-trasplante, estrategias de afrontamiento, duración de la enfermedad, etiología del trasplante, procedencia del órgano implantado y otras variables; 3 fases psicológicas en los trasplantados renales, hepáticos y cardíacos en función de diferentes periodos temporales de comparación; 4 calidad de vida en los trasplantados y variables que la predicen: adherencia terapéutica, hospitalización, apoyo familiar, expectativas hacia el trasplante y etiología del trasplante; y 5 repercusiones psicológicas del trasplante de órganos en los familiares, teniendo en cuenta la influencia que ejerce el apoyo social sobre la salud mental de estos familiares.

  11. Short-tem Post Renal Trasplant Follow-up at Madinah Al Munawarah

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    Bernieh Bassam

    1999-01-01

    Full Text Available We reviewed the records of the renal transplant patients followed at our hospital to determine short-term outcome and complications. Sixty-five renal transplant patients, follow-up for two years were included in this study. Of these patients 40 (61.5% were males, 33 (50.7% were Saudis with mean age of 37.2 ± 11.7 years. Donors were living related (LRD in 23 (35%, living non-related (LNRD in 27 (42% and cadaveric (CAD in 15 (23%. Thirty-two transplants were carried out at Medinah, 21 in India and the rest in other centers inside Saudi Arabia. Immunosuppression was based on a triple therapy (Cyclosporin, Azathioprine, and Prednisone. At two years, 52 (80% patients were alive, with functioning graft in 31 (58%. Causes of death among 13 patients (11 LNRD & 2 CAD were infections in 7 (54%, immediate post transplant in three (22.7%, acute myocardial infarction in two (15.7%, CVA in one (7.6%. Complications encountered were acute rejection (23 episodes in 18 923.6% patients, infections in 19 (25%, chronic rejection in 16 (21.5%, surgical in 13 917.1%, diabetes mellitus in 5 (6.5% primary non-function in three (3.8% and Kaposi Sarcoma in two (2.4%. Twenty-six (81.25% out of 32 transplants performed in Madinah were functioning, four (12.5% patients returned to dialysis and two (6.25% patients died. Among the 21 transplants done in India 11 (52% patients died, six (28.6% returned to dialysis, and four (19.4% had function deteriorated in all patients. We conclude that despite limitations, results of renal transplantation carried out at Madinah are encouraging on short-term basis. Live related transplant has a very good outcome, while commercial transplantation carries poor prognosis.

  12. Evolucion de niños post-trasplante hepático luego del primer año de sobrevida Evolution of children one year post liver transplant

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    Miriam Cuarterolo

    2005-10-01

    Full Text Available El trasplante hepático constituye la única alternativa terapéutica para numerosas enfermedades hepáticas avanzadas. En el seguimiento post-trasplante pueden observarse complicaciones de diversa gravedad. El objetivo de este estudio fue analizar la evolución a largo plazo de los pacientes trasplantados con un seguimiento mayor de un año post quirúrgico. En el período 11/92-11/01 se realizaron 264 trasplantes en 238 pacientes; incluyéndose en este trabajo 143 niños con más de un año post-trasplante. La mediana de edad ± DS fue de 5.41 ± 5.26 años (r: 0.58-21.7 años. Catorce (9.79% fueron retrasplantados. Todos los pacientes recibieron ciclosporina (inmunosupresión primaria. Las indicaciones de trasplante fueron: falla hepática fulminante (n: 50; atresia de vías biliares (n: 38; cirrosis (n: 37; colestasis crónica (n: 13 y otras (n: 5. Las indicaciones de retrasplante fueron: cirrosis biliar (n: 7; trombosis de la arteria hepática (n: 4 y rechazo crónico (n: 3. Fueron utilizados injertos reducidos en 73/157 trasplantes(14 donantes vivos relacionados y 11 biparticiones hepáticas. La sobrevida global fue de 93%, paciente y 86%, injerto. El retrasplante y el injerto reducido fueron las variables de mayor significación para el aumento del riesgo de muerte. El déficit de talla y masa ósea se recuperó antes de los 3años post-trasplante. La incidencia de síndrome linfoproliferativo fue del 7.69%. Se diagnosticó hepatitis B de novo en 7 pacientes (4.8%. El riesgo social no afectó la sobrevida. La prevención, detección y tratamiento precoz de las complicaciones en el seguimiento a largo plazo permitió mejorar la evolución de los pacientes.Orthotopic liver transplantation is the only definitive mode of therapy for children with end-stage liver disease. However, it remains challenging because of the necessity to prevent long-term complications. The aim of this study was to analyze the evolution of transplanted patients with

  13. TOLERANCIA DEL TOMATE (Lycopersicon esculentum Mill.) A APLICACIONES POST TRASPLANTE DEL HERBICIDA HALOSULFURON-METIL Tomato (Lycopersicon esculentum Mill.) tolerance to post transplant applications of the herbicide halosulfuron-methyl

    OpenAIRE

    Juan Ormeño N; Francisco Fuentes V.; Verónica Soffia C.

    2003-01-01

    Durante la temporada 1998/99 en el Centro Regional de Investigación La Platina del Instituto de Investigaciones Agropecuarias (INIA) (33º34’ lat. Sur, 70º38’ long. Oeste, 625 m.s.n.m.), en un suelo franco-arcilloso, se realizaron ensayos para determinar la tolerancia de tomate (Lycopersicon esculentum Mill.) de los cultivares industriales H-993, P-76, APT-127, APT-410 y cultivares de consumo fresco Cal Ace y XPH-12221 a aplicaciones de post trasplante de halosulfurón-metil (Sempra® 75 WG) en ...

  14. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible Pure red cell aplasia after ABO incompatible bone marrow transplantation

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    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.ABO incompatibility in allogeneic bone marrow transplantation may be associated with incomplete or delayed erythroid engraftment, being pure red cell aplasia (PRCA the most severe complication in this setting. Attempts for the treatment of PRCA have been made with erythropoietin or with plasmapheresis with relative success, and some authors have reported the reversibility of PRCA with antilymphocyte globulin (ALG or ATG, based on the assumption that PRCA might be immunologically mediated. We report herewith a patient with acute leukemia who developed post - BMT pure red cell aplasia. His sibling donor (sister was HLA identical and ABO incompatible, having low agglutinin

  15. Trasplante renal Kidney transplant

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    P. Martín

    2006-08-01

    Full Text Available El trasplante renal es la terapia de elección para la mayoría de las causas de insuficiencia renal crónica terminal porque mejora la calidad de vida y la supervivencia frente a la diálisis. El trasplante renal de donante vivo es una excelente alternativa para el paciente joven en situación de prediálisis porque ofrece mejores resultados. El tratamiento inmunosupresor debe ser individualizado buscando la sinergia inmunosupresora y el mejor perfil de seguridad, y debe adaptarse a las diferentes etapas del trasplante renal. En el seguimiento del trasplante renal hay que tener muy en cuenta los factores de riesgo cardiovascular y los tumores puesto que la muerte del paciente con injerto funcionante es la segunda causa de pérdida del injerto tras el primer año del trasplante. La función alterada del injerto es un factor de mortalidad cardiovascular independiente que requerirá seguimiento y control de todas sus complicaciones para retrasar la entrada en diálisis.The kidney transplant is the therapy of choice for the majority of the causes of chronic terminal kidney insufficiency, because it improves the quality of life and survival in comparison with dialysis. A kidney transplant from a live donor is an excellent alternative for the young patient in a state of pre-dialysis because it offers the best results. Immunosuppressive treatment must be individualised, seeking immunosuppressive synergy and the best safety profile, and must be adapted to the different stages of the kidney transplant. In the follow-up to the kidney transplant, cardiovascular risk factors and tumours must be especially taken into account, given that the death of the patient with a working graft is the second cause of loss of the graft following the first year of the transplant. The altered function of the graft is a factor of independent cardiovascular mortality that will require follow-up and the control of all its complications to postpone the entrance in dialysis.

  16. Trasplante mecanizado de hortalizas

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    F. Muñoz Gómez

    2006-01-01

    Full Text Available En el trabajo se realiza el análisis de los parámetros de funcionamiento de una máquina trasplantadora de alimentación manual del tipo de pinzas, para que las plántulas queden verticales en el suelo y con la distancia especificada según el tipo de cultivo, obteniéndose los resultados de las pruebas de trasplante en campo de tomate de cáscara, el objetivo fue generar datos para calcular los valores teóricos del parámetro lp de 6 variedades de hortalizas. En las pruebas de trasplante en el campo los parámetros a medir fueron: velocidad de avance de la máquina, distancia entre plantas, inclinación de las plantas, profundidad de plantación. Las pruebas se realizaron en una parcela con 12 surcos de 140 metros de largo y 1,40 metros entre surcos. Los tres primeros se utilizaron para hacer las calibraciones y ajustes necesarios de los parámetros de trabajo de la máquina. Los resultados del trabajo arrojaron que los valores de lp calculados mediante las pruebas de laboratorio se pueden utilizar como parámetros para calcular la cadena cinemática de la máquina o como parámetros de referencia para ajustar la relación de transmisión de la máquina cuando se requiere investigar las distancias de plantación para que las plántulas queden trasplantadas de forma vertical en el suelo, así como que la calidad de trabajo durante el trasplante en campo depende de factores que son ajenos a la máquina

  17. Late post transplant HIV infection with BK viremia and allograft tuberculosis in a renal transplant recipient with Kaposi sarcoma

    OpenAIRE

    Viswanathan, V.; Kandasamy, V.; Reddy, Y. N.; Kurien, A.; Mathew, M.; Abraham, G

    2012-01-01

    In this report, we discuss a case of a 51-year-old African renal transplant who presented with metastatic Kaposi sarcoma 1 year after transplant. The Kaposi sarcoma was treated with a switch of immunosuppressants and chemotherapy. Six years after transplant, he presented with chronic allograft nephropathy, allograft tuberculosis, BK viremia, and was diagnosed to have contracted HIV infection.

  18. TOLERANCIA DEL TOMATE (Lycopersicon esculentum Mill. A APLICACIONES POST TRASPLANTE DEL HERBICIDA HALOSULFURON-METIL Tomato (Lycopersicon esculentum Mill. tolerance to post transplant applications of the herbicide halosulfuron-methyl

    Directory of Open Access Journals (Sweden)

    Juan Ormeño N.

    2003-04-01

    Full Text Available Durante la temporada 1998/99 en el Centro Regional de Investigación La Platina del Instituto de Investigaciones Agropecuarias (INIA (33º34’ lat. Sur, 70º38’ long. Oeste, 625 m.s.n.m., en un suelo franco-arcilloso, se realizaron ensayos para determinar la tolerancia de tomate (Lycopersicon esculentum Mill. de los cultivares industriales H-993, P-76, APT-127, APT-410 y cultivares de consumo fresco Cal Ace y XPH-12221 a aplicaciones de post trasplante de halosulfurón-metil (Sempra® 75 WG en la dosis recomendada 75 g ha-1 y en sobredosis de 150 y 300 g ha-1. En todas las dosis halosulfurón-metil no produjo síntomas adversos importantes sobre el follaje. Los mayores niveles de decoloración foliar se observaron en la sobredosis 300 g ha-1 en el cv. P-76 siete días después de la aplicación (DDA. Esta fitotoxicidad fue temporal, restringida a 7-15 DDA, desapareciendo casi completamente 21 DDA. No hubo reducciones en alto y ancho de las plantas 30 DDA, a excepción del ancho del cv. P-76 a 300 g ha-1. 0El rendimiento individual y total de frutos en los cvs. Cal Ace, XPH-12221, H-993, APT-127 y APT-410 no fueron afectados por las aplicaciones de halosulfurón-metil. Ninguna dosis produjo efectos adversos en el diámetro ecuatorial y polar de los frutos. El híbrido industrial P-76 tuvo una baja significativa en rendimiento y número de frutos planta-1 a 150 y 300 g ha-1, pero no con la dosis de 75 g ha-1. Las plantas de tomate fueron tolerantes a aplicaciones tempranas de post trasplante en la dosis máxima recomendada de halosulfurón-metil.During the 1998/99 season at La Platina Research Regional Center of the National Agricultural Research Institute (INIA (33º34’ S lat, 70º38’ W long, altitude 625 m.o.s.l., on a loamy-clay soil, field trials were conducted to determine crop tolerance of tomatoes (Lycopersicon esculentum Mill. of the industrial cultivars H-993, P-76, APT-127, APT-410, and fresh consumption cultivars Cal Ace, and XPH

  19. Trasplante pulmonar Lung transplant

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    M. Espinosa

    2006-08-01

    Full Text Available El transplante pulmonar suele ser la última opción terapéutica para pacientes con insuficiencia respiratoria. A pesar de los muchos avances en inmunología y el manejo de las complicaciones, la mortalidad y morbilidad asociadas a este trasplante son muy superiores a los demás. El rechazo agudo es casi un problema universal en el primer año, mientras que la bronquiolitis obliterante limita la supervivencia a largo plazo. Las infecciones respiratorias también cumplen un papel importante en las complicaciones asociadas al trasplante pulmonar por la constante exposición del injerto al medio exterior. No obstante, los éxitos de esta opción terapéutica que depende fundamentalmente de una correcta selección de donante y receptor, son evidentes, sobre todo en cuanto a calidad de vida se refiere.A lung transplant is usually the final therapeutic option for patients with respiratory insufficiency. In spite of the many advances in immunology and the management of complications, mortality and morbidity associated with this transplant are far higher than with others. Acute rejection is an almost universal problem in the first year, while obliterative bronchitis reduces long term survival. Respiratory infections also play a significant role in the complications associated with lung transplants due to the constant exposure of the graft to the outside. However, the success of this therapeutic option, which basically depends on a suitable selection of donor and recipient, are evident, above all with respect to quality of life.

  20. Trasplante hepático Liver transplantation

    OpenAIRE

    Herrero, J. I.; Pardo, F.; J. Quiroga; F. Rotellar

    2006-01-01

    El trasplante hepático es una opción terapéutica eficaz para las enfermedades hepáticas terminales. Las principales indicaciones del trasplante hepático son la cirrosis hepática, los tumores hepáticos (fundamentalmente, el hepatocarcinoma) y la insuficiencia hepática aguda grave. Con el paso de los años, las contraindicaciones absolutas para el trasplante se han ido reduciendo. La técnica quirúrgica también ha sufrido modificaciones. Los resultados del trasplante hepático han mejorado, de for...

  1. Trasplante Renal: una mejor alternativa para los nefrópatas crónicos

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    Fernando Renjel Claros

    2010-06-01

    Full Text Available El trasplante renal desde 1954, cuando se realizó el primer trasplante renal exitoso en gemelos monocigóticos en el “PeterBent Brigham Hospital”, hasta ahora se considera como la mejor alternativa para los pacientes que tienen Enfermedad Renal Crónica Avanzada, ya que restablece no solamente la salud del paciente con enfermedad renal, sino que lo reintroduce a las actividades sociales, laborales y hasta físicas. El trasplante renal es un tratamiento eficaz, de alto costo en nuestro medio, pero accesible y más económico en relación al financiamiento que se requiere para mantener un paciente en hemodiálisis.Actualmente el trasplante renal es realizado en varios centros hospitalarios en todo el mundo con grandes resultados, por lo que el objetivo de la presente revisión es prestar información sobre la selección del donante y receptor, las contraindicaciones del trasplante, el manejo pre y post-trasplante y las complicaciones que se puedan presentar.

  2. Trasplante óseo

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    San-Julian, M.; Valenti, A

    2006-01-01

    We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there a...

  3. Trasplante hepático Liver transplantation

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    J. I. Herrero

    2006-08-01

    Full Text Available El trasplante hepático es una opción terapéutica eficaz para las enfermedades hepáticas terminales. Las principales indicaciones del trasplante hepático son la cirrosis hepática, los tumores hepáticos (fundamentalmente, el hepatocarcinoma y la insuficiencia hepática aguda grave. Con el paso de los años, las contraindicaciones absolutas para el trasplante se han ido reduciendo. La técnica quirúrgica también ha sufrido modificaciones. Los resultados del trasplante hepático han mejorado, de forma que la supervivencia al año del trasplante está próxima al 90% y a los cinco años, un 80% de los pacientes trasplantados siguen vivos.Liver transplantation is an efficient therapeutic option for terminal hepatic diseases. The principal indications of liver transplantation are hepatic cirrhosis, hepatic tumours (mainly, hepotocellular carcinoma and acute liver failure. Over the years, the absolute contraindications for a transplant have lessened. Surgical techniques have also undergone changes. The results of liver transplant have improved so that survival one year after the transplant is close to 90% and after five years some 80% of transplanted patients continue to live.

  4. Developmental expression of BK channels in chick cochlear hair cells

    Directory of Open Access Journals (Sweden)

    Tong Mingjie

    2009-12-01

    Full Text Available Abstract Background Cochlear hair cells are high-frequency sensory receptors. At the onset of hearing, hair cells acquire fast, calcium-activated potassium (BK currents, turning immature spiking cells into functional receptors. In non-mammalian vertebrates, the number and kinetics of BK channels are varied systematically along the frequency-axis of the cochlea giving rise to an intrinsic electrical tuning mechanism. The processes that control the appearance and heterogeneity of hair cell BK currents remain unclear. Results Quantitative PCR results showed a non-monotonic increase in BK α subunit expression throughout embryonic development of the chick auditory organ (i.e. basilar papilla. Expression peaked near embryonic day (E 19 with six times the transcript level of E11 sensory epithelia. The steady increase in gene expression from E11 to E19 could not explain the sudden acquisition of currents at E18-19, implicating post-transcriptional mechanisms. Protein expression also preceded function but progressed in a sequence from diffuse cytoplasmic staining at early ages to punctate membrane-bound clusters at E18. Electrophysiology data confirmed a continued refinement of BK trafficking from E18 to E20, indicating a translocation of BK clusters from supranuclear to subnuclear domains over this critical developmental age. Conclusions Gene products encoding BK α subunits are detected up to 8 days before the acquisition of anti-BK clusters and functional BK currents. Therefore, post-transcriptional mechanisms seem to play a key role in the delayed emergence of calcium-sensitive currents. We suggest that regulation of translation and trafficking of functional α subunits, near voltage-gated calcium channels, leads to functional BK currents at the onset of hearing.

  5. Eventraciones post-trasplante renal: análisis de factores de riesgo y técnica quirúrgica / Post kidney transplantatios incisional hernia: risk factors analysis and surgical repair techniques

    Directory of Open Access Journals (Sweden)

    Santa Maria Victoria

    2015-11-01

    Full Text Available Several factors increase the risk of insicional hernias post-kidney transplantation and different surgical techniques exist for solving this problem. A retrospective study analyzing the risk factors for developing an insicional hernia and eventroplasties made in the kidney transplants performed between 2006-2013 was performed. The incidence of hernias was 12.7%. All elements studied were statistically independent of the appearance of hernias, probably by influence when combined together and not each separately. Consistent with the literature in which patients did not mesh was used or an absorbable mesh used had a recurrence of 100%. It should be more study of the risk factors that influence the development of post-transplant hernias because of the contradictions that arise from the literature. Post-transplant renal ventral hernia repair is safe and effective provided it is carried out for non-resorbable mesh. The risk of post-surgical infections does not appear to be affected by the use of mesh when the necessary precautions are taken, and if it does not change the prognosis.

  6. Trasplante de córnea Cornea transplant

    Directory of Open Access Journals (Sweden)

    A. Garralda

    2006-08-01

    Full Text Available La queratoplastia o trasplante de córnea es una de las técnicas quirúrgicas más antiguas de la oftalmología cuyas indicaciones son: 1 tectónicas, para preservar la anatomía e integridad corneal, 2 clínicas, para eliminar el tejido corneal inflamado en casos refractarios al tratamiento médico, 3 ópticas, para mejorar la agudeza visual y 4 cosméticas para mejorar el aspecto del ojo. El perfeccionamiento en la técnica y en el instrumental, así como en el tratamiento postoperatorio y en los medios de conservación del tejido donante han mejorado la supervivencia de los injertos realizados. El Modelo Pamplona de coordinación de trasplantes del Hospital Virgen del Camino (HVC está considerado como original y único en España, y en la logística de este programa se incluye el protocolo de detección y extracción de córneas así como el de queratoplastias.The keratoplasty, or corena transplant, is one of the oldest surgical techniques in opthalmology, whose indication are: 1 tectonic, in order to preserve corneal anatomy and integrity; 2 clinical, in order to eliminate the inflamed corneal tissue in cases refractory to medical treatment; 3 optical, in order to improve visual acuity; and 4 cosmetic, in order to improve the appearance of the eye. Improvements in technique and instruments, as well as in post-operative treatment and the means of preserving donated tissue, have improved survival of the grafts. The Pamplona Model of transplant coordination of the Virgen del Camino Hospital is considered to be original and unique in Spain. The logistics of this program include the protocol for detection and extraction of corneas as well as for keratoplasties.

  7. Series BK contactless DC motors

    Energy Technology Data Exchange (ETDEWEB)

    Buss, V.A.; Vevyurko, I.A.; Ivanov, G.V.; Kuzmin, V.N.; Mikhaylov, E.M.; Stoma, A.S.

    1985-05-01

    Implementation of principles described in a previous work has allowed development and introduction to series production of a motor series including 36 standard types and sizes. The series is designed to operate at a nominal voltage of 27 V and includes two main versions: the BK-1 for fans and BK-2 for pumps. The BK-2 motor differs from the BK-1 in that it has a thin sealed sleeve of high impedance nonmagnetic metal separating the rotor and stator cavities, allowing the rotor of the BK-2 to operate in the fluids or other media being pumped. Characteristics of the motors are presented. The BK-1316 has an operating life of about 50,000 hours at nominal speed of 6000 rpm. The experience of series production of the BK motors has shown the need for further improvement of the design and technology in order to decrease the number of metal cutting, winding and assembly operations required. The use of plastic structures is suggested to this end.

  8. Trasplante pancreático Pancreatic transplant

    Directory of Open Access Journals (Sweden)

    M. C. Montiel

    2006-08-01

    Full Text Available La diabetes mellitus constituye una preocupación sanitaria de primer orden, dado el alto índice de morbimortalidad asociada. El objetivo para frenar el avance de sus complicaciones, antes de que éstas sean irreversibles, se basa en un control metabólico correcto. La alta tasa de morbilidad asociada a la cirugía del trasplante vascularizado de páncreas y el alto índice de rechazo ha constituido durante tres décadas un obstáculo para que se considerara a éste como una alternativa válida en el tratamiento de estos pacientes. El trasplante de páncreas hoy día ha pasado a ocupar un lugar primordial, gracias a los nuevos regímenes de inmunosupresión y al perfeccionamiento de la técnica quirúrgica. En este capítulo revisamos la evolución del trasplante de páncreas desde sus inicios y su situación actual.Diabetes mellitus is a health concern of the first order, given the high level of associated morbidity and mortality. The objective, in order to slow down the advance of its complications before they become irreversible, is based on correct metabolic control. The high rate of morbidity associated with the surgery of the vascularized pancreas transplant and the high index of rejection have for three decades formed an obstacle to this being considered a valid alternative in the treatment of these patients. Nowadays the pancreas transplant has come to occupy a key position, thanks to the new regimes of immunosuppression and to the perfection of surgical techniques. In this article we review the evolution of the pancreas transplant from its beginnings to its present state.

  9. BK channel modulators: a comprehensive overview

    DEFF Research Database (Denmark)

    Nardi, Antonio; Olesen, Søren-Peter

    2008-01-01

    the multitude of chemical entities claimed to be BK-modulating agents. Such chemical entities are, herein, classified by both origin and chemical structure in 1) Endogenous BK channel modulators and structural analogues 2) Naturally-occurring BK channel inhibitors and blockers 3) Synthetic BK channel...... inhibitors and blockers 4) Marketed and/or investigational drugs with BK-modulating side properties and structural analogues 5) Naturally-occurring BK channel openers and structural analogues 6) Synthetic BK channel openers. This review is intended to provide readers with current opinion on the BK channel as...... a drug target, the chemical structures of BK channel modulators, the structural and chemical features involved in the BK channel modulating activity and, where and when possible, with highlights of structure-activity relationships....

  10. Trasplante pancreático Pancreatic transplant

    OpenAIRE

    Montiel, M. C.; Pardo, F; F. Rotellar; V. Valentí; Pastor, C.; J. Álvarez Cienfuegos

    2006-01-01

    La diabetes mellitus constituye una preocupación sanitaria de primer orden, dado el alto índice de morbimortalidad asociada. El objetivo para frenar el avance de sus complicaciones, antes de que éstas sean irreversibles, se basa en un control metabólico correcto. La alta tasa de morbilidad asociada a la cirugía del trasplante vascularizado de páncreas y el alto índice de rechazo ha constituido durante tres décadas un obstáculo para que se considerara a éste como una alternativa válida en el t...

  11. Silicosis y trasplante pulmonar Lung transplantation in silicosis

    OpenAIRE

    MARÍA TERESA PARADA C; VÍCTOR ALISTE C; RODRIGO GIL D; PATRICIO RODRÍGUEZ D; MAURICIO FICA D; CRISTINA HERZOG O; LORENA CALABRÁN R; ALVARO UNDURRAGA P

    2007-01-01

    La silicosis es una enfermedad prevalente en Chile, que es un país minero y en desarrollo. Existe escasa bibliografía sobre trasplante pulmonar, como alternativa de tratamiento en silicosis avanzada. Objetivo: Describir el tiempo y forma de exposición a la sílice y las características clínicas de enfermos silicóticos tratados con trasplante pulmonar en la Clínica Las Condes de Santiago. Pacientes y Métodos: De un total de 38 pacientes en los que se practicó trasplante pulmonar entre 1999 y 20...

  12. Reconsitución inmunológica en niños receptores de trasplantes de progenitores hematopoyéticos

    OpenAIRE

    Lessa de Castro, Selma

    2001-01-01

    Introducción: El Trasplante de Células Progenitores Hematopoyéticas (TPH) es una modalidad terapéutica muy eficaz en el tratamiento de muchas de las neoplasias onco-hematológicas y algunas hemopatias congénitas e inmunodeficiencias primarias. Entre los factores que pueden interferir en la reconstitución inmunológica post-TPH se encuentran: la fuente de progenitores hematopoyéticos (médula ósea (MO), sangre de cordón umbilical (SCU), sangre periférica (SP)), el tipo de trasplante (autólogo o a...

  13. EC decay of 244Bk

    Science.gov (United States)

    Sodaye, Suparna; Tripathi, R.; Sudarshan, K.; Sharma, S. K.; Pujari, P. K.; Palit, R.; Mukhopadhyay, S.

    2014-12-01

    Berkelium isotopes have been produced in 11B-induced reaction on 238U. The EC decay of 244Bk → 244Cm has been studied by carrying out the single and coincidence measurements of the γ-rays emitted during the de-excitation of the 244Cm levels. Radiochemical separations have been carried out to minimize the contribution from the fission products and target. The new half-life of 244Bk is obtained as 5.02 ± 0.03 h, which is close to the theoretically calculated value. The relative intensities of the decay γ-rays have been re-evaluated. Based on the coincidence measurements, a tentative partial level scheme for 244Bk → 244Cm decay has been proposed.

  14. EC decay of 244Bk

    International Nuclear Information System (INIS)

    Berkelium isotopes have been produced in 11B-induced reaction on 238U. The EC decay of 244Bk → 244Cm has been studied by carrying out the single and coincidence measurements of the γ-rays emitted during the de-excitation of the 244Cm levels. Radiochemical separations have been carried out to minimize the contribution from the fission products and target. The new half-life of 244Bk is obtained as 5.02 ± 0.03 h, which is close to the theoretically calculated value. The relative intensities of the decay γ-rays have been re-evaluated. Based on the coincidence measurements, a tentative partial level scheme for 244Bk → 244Cm decay has been proposed. (paper)

  15. Biophysics of BK Channel Gating.

    Science.gov (United States)

    Pantazis, A; Olcese, R

    2016-01-01

    BK channels are universal regulators of cell excitability, given their exceptional unitary conductance selective for K(+), joint activation mechanism by membrane depolarization and intracellular [Ca(2+)] elevation, and broad expression pattern. In this chapter, we discuss the structural basis and operational principles of their activation, or gating, by membrane potential and calcium. We also discuss how the two activation mechanisms interact to culminate in channel opening. As members of the voltage-gated potassium channel superfamily, BK channels are discussed in the context of archetypal family members, in terms of similarities that help us understand their function, but also seminal structural and biophysical differences that confer unique functional properties. PMID:27238260

  16. New berkelium isotope: 242Bk

    International Nuclear Information System (INIS)

    A new isotope of berkelium, 242Bk, was produced with a cross section of approx. 10 μb in reactions of boron on uranium and nitrogen on thorium. It decays by electron capture with a half-life of 7 +- 1.3 minutes. The branching ratio for this isotope for alpha decay is less than 1% and that for spontaneous fission is less than 0.03%. 2 figures, 2 tables

  17. Update on BK with Wilson fermions

    International Nuclear Information System (INIS)

    The K-anti K mixing matrix element is a hadronic matrix element that is of crucial importance to electroweak phenomenology. For convenience, the authors introduce the so called bag parameter, BK. It has been known for a long time that BK is amenable to lattice Monte-Carlo methods. Indeed, recently Sharpe and collaborators, using staggered formulation for fermions have made remarkable progress in calculating BK and have reported a result with an impressive accuracy. In this work the authors will present their results for BK using the Wilson formulation for fermions

  18. Certeza diagnóstica en la mortalidad de una población de pacientes con trasplante cardíaco

    Directory of Open Access Journals (Sweden)

    Marcos Amuchástegui

    2008-01-01

    Full Text Available RESUMENIntroducciónA pesar de que la morbimortalidad en el trasplante cardíaco ha sido motivo de extensoanálisis, la mayoría de los estudios y registros de mortalidad en pacientes trasplantados sebasan sobre datos clínicos. En la bibliografía existen comunicaciones aisladas de autopsiasen pacientes con trasplante cardíaco.ObjetivoDeterminar la importancia de la realización de estudios anatomopatológicos para el diagnósticode causa de muerte en un programa de trasplante cardíaco.Material y métodosSe incluyeron todos los pacientes con trasplante cardíaco fallecidos entre enero 1990 y enero2005. El diagnóstico definitivo de la causa de muerte fue corroborado por autopsia obiopsia de órgano sólido. Las causas de muerte evaluadas fueron falla precoz del injerto,rechazo celular, infección, enfermedad vascular del injerto, neoplasia y otros.ResultadosDurante el período en estudio 73 pacientes fueron sometidos a trasplante cardíaco; de ellos,fallecieron 31. Se obtuvieron 12 autopsias y 7 biopsias de órgano sólido que certificaron lacausa de muerte (61%. La causa de muerte más frecuente fue el rechazo celular mayor degrado III. En el 12,9%, la anatomía patológica difirió de la sospecha clínica de la causa demuerte.ConclusiónLa información clinicopatológica derivada de estudios post mortem es un indicador de nuestrarealidad asistencial y se constituye en un pilar fundamental para el conocimiento y elmanejo futuro de los pacientes trasplantados, por lo que consideramos que la realización deautopsias en estos pacientes es de vital importancia.REV ARGENT CARDIOL 2008;76:292-294.

  19. Certeza diagnóstica en la mortalidad de una población de pacientes con trasplante cardíaco

    Directory of Open Access Journals (Sweden)

    Marcos Amuchástegui (h,

    2006-01-01

    Full Text Available Introducción A pesar de que la morbimortalidad en el trasplante cardíaco ha sido motivo de extenso análisis, la mayoría de los estudios y registros de mortalidad en pacientes trasplantados se basan sobre datos clínicos. En la bibliografía existen comunicaciones aisladas de autopsias en pacientes con trasplante cardíaco.Objetivo Determinar la importancia de la realización de estudios anatomopatológicos para el diagnóstico de causa de muerte en un programa de trasplante cardíaco.Material y métodosSe incluyeron todos los pacientes con trasplante cardíaco fallecidos entre enero 1990 y enero 2005. El diagnóstico definitivo de la causa de muerte fue corroborado por autopsia o biopsia de órgano sólido. Las causas de muerte evaluadas fueron falla precoz del injerto, rechazo celular, infección, enfermedad vascular del injerto, neoplasia y otros.ResultadosDurante el período en estudio 73 pacientes fueron sometidos a trasplante cardíaco; de ellos, fallecieron 31. Se obtuvieron 12 autopsias y 7 biopsias de órgano sólido que certificaron la causa de muerte (61%. La causa de muerte más frecuente fue el rechazo celular mayor de grado III. En el 12,9%, la anatomía patológica difirió de la sospecha clínica de la causa de muerte.ConclusiónLa información clinicopatológica derivada de estudios post mortem es un indicador de nuestra realidad asistencial y se constituye en un pilar fundamental para el conocimiento y el manejo futuro de los pacientes trasplantados, por lo que consideramos que la realización de autopsias en estos pacientes es de vital importancia.

  20. B_K from improved staggered quarks

    OpenAIRE

    Gamiz, E.; Collins, S.; Davies, C. T. H.; Shigemitsu, J.; Wingate, M

    2004-01-01

    We compare calculations of B_K with improved staggered quarks (HYP, Asqtad) and demonstrate the improved scaling behaviour that this gives rise to over previous calculations with unimproved staggered quarks. This enables us to perform the calculation of B_K on the MILC dynamical configurations (n_f=2+1), for which we give preliminary results.

  1. BK channel activators and their therapeutic perspectives

    DEFF Research Database (Denmark)

    Bentzen, Bo Hjorth; Olesen, Søren-Peter; Rønn, Lars C B;

    2014-01-01

    The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increase...... years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.......The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases...... in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent...

  2. Experiencia con micofenolato mofetil en el trasplante renal

    OpenAIRE

    Esteban de la Rosa, Rafael Jos??

    2001-01-01

    Micofenolato mofetil (MMF) es un potente inmunosupresor, libre de efecto nefrot??xico, eficaz en la prevencion de rechazo agudo y en la nefropatia cronica del trasplante renal. Bloquea la fase de sintesis sobre la estirpe linfocitaria a trav??s de inhibici??n selectiva, reversible y no competitiva de la enzima inosin-monofosfato-deshidrogenasa(IMPDH), clave en la biosintesis de novo de las purinas. OBJETIVOS:Se evaluaron tres grupos de trasplantados renales (TR) seg??n la terapia inmunosupres...

  3. [BK virus infections in kidney transplantation].

    Science.gov (United States)

    Lanot, Antoine; Bouvier, Nicolas; Chatelet, Valérie; Dina, Julia; Béchade, Clémence; Ficheux, Maxence; Henri, Patrick; Lobbedez, Thierry; Hurault de Ligny, Bruno

    2016-04-01

    BK virus is near ubiquitous, with a seroprevalence of around 80% in the general population. Subsequent to an asymptomatic primary infection, BK virus then remains dormant in healthy subjects. Reactivation occurs in immunocompromised people. BKv is pathogenic mainly among patients who have received a kidney transplant, in whom the virus can cause specific tubulo-interstitial nephritis and even result in graft failure among approximately 20 to 30% of nephritic cases. Since the mid 90s, incidence has increased with the use of new powerful immunosuppressor treatments. The cornerstone of BK virus infection or BK virus-associated nephropathy treatment is a decrease of the immunosuppressive regimen, which must then be offset with the risk of rejection. The use of several adjuvant therapies has been submitted (fluoroquinolones, leflunomide, intravenous immunoglobulins, cidofovir), with no sufficient proof enabling the recommendation of first-line prescription. The high frequency of this infection and its potential harmfulness argue for the use of prevention strategies, at least among patients presenting risk factors. Retransplantation is safe after a first kidney allograft loss caused by BK-virus nephropathy, on condition that a screening for viremia is frequently conducted. PMID:26827190

  4. Aplastamientos vertebrales tras un trasplante hepático

    OpenAIRE

    Seral García, Belén; Bello Nicolau, M. L.; Seral Iñigo, Fernando

    1998-01-01

    En la evolución de un paciente sometido a un trasplante hepático existe una importante morbilidad con complicaciones musculoesqueléticas, especialmente debido a la osteopaina que sufren con fracturas patológicas y necrosis avasculares. Es un tema importante puesto que son pacientes jóvenes, que se encuentran sometidos a quimioterapia inmunosupresora intensiva. Además no existe una terapia profiláctica efectiva ni tratamiento de las complicaciones. Presentamos el caso de un niño de 16 años de ...

  5. BK virus infection in a renal transplant Saudi child

    International Nuclear Information System (INIS)

    BK human polyomavirus (BKV) causes an asymptomatic primary infection in children, but later, establishes latency mainly in the urinary tract. Virus-host interactions influencing persistence and pathogenicity are not well-understood. We present here a 12-year-old Saudi boy, who had renal transplant in Egypt. Seven months later, he was admitted to our Pediatric Nephrology Unit as a case of renal impairment. He developed BKV infection, diagnosed and successfully managed in our hospital. This case demonstrates the expanding clinical importance of BKV in a post renal transplant patient. This virus can be detected in transitional cells in the urine (decoy cells) using cytology. Testing for BKV deoxyribonucleic acid in urine and blood is an early detection assay, and can be used as a screening test in the early stages. The early reduction of immunosuppression can improve the prognosis. No specific antiviral treatment has been established yet. This is the first report of detecting BK virus in a Saudi post-transplant child in urine and blood specimens by using polymerase chain reaction. (author)

  6. Problemas psicológicos asociados al trasplante de órganos

    OpenAIRE

    María Ángeles Pérez San Gregorio; Agustín Martín Rodríguez; Antonio Galán Rodríguez

    2005-01-01

    El trasplante de órganos es una alternativa terapéutica para aquellos pacientes que tienen problemas graves en el funcionamiento de un órgano vital: corazón, hígado, pulmón, etc. Dada la relevancia de este tema, en el presente estudio teórico analizamos los principales problemas psicológicos asociados al trasplante de órganos. Concretamente, hemos tenido en cuenta los siguientes apartados: 1) Repercusiones psicológicas del trasplante de órganos en los pacientes: delirium, trast...

  7. Trasplante hepático: Implicaciones nutricionales Liver transplant: Nutritional implications

    Directory of Open Access Journals (Sweden)

    J. C. Montejo González

    2008-05-01

    Full Text Available La mayoría de los pacientes candidatos a trasplante hepático presentan malnutrición de diversa magnitud. Debido a ello, pueden ser subsidiarios de un tratamiento nutricional con vistas a mejorar el estado nutricional y los resultados del trasplante. No obstante, el soporte preoperatorio es de difícil realización en muchos casos debido a múltiples factores entre los que se encuentran la situación clínica de los pacientes, los requerimientos diagnósticos, las pautas de tratamiento y la atención extrahospitalaria de los candidatos "estables". En la fase postoperatoria, los pacientes deben recibir soporte nutricional del mismo modo que otros pacientes sometidos a cirugía mayor. La nutrición enteral precoz es el método más adecuado en la mayoría de los casos, para lo que es recomendable la colocación intraoperatoria de una vía de acceso transpilórico al tracto digestivo, habitualmente una sonda naso-yeyunal. La nutrición enteral debe mantenerse hasta que los requerimientos nutricionales puedan ser adecuadamente cubiertos mediante la ingesta oral. El tratamiento inmunosupresor, a través de sus efectos secundarios con incidencia metabólico-nutricional, contribuye de manera importante al desarrollo de problemas de esta índole tras el trasplante. Los pacientes precisan seguimiento nutricional no sólo para valorar la evolución de su estado de nutrición sino también para detectar, prevenir y tratar las alteraciones tardías que, como la obesidad, la hiperlipemia o la osteoporosis, aparecen con frecuencia en estos pacientes.Most of the patients who are candidate to liver transplant have varying degrees of hyponutrition. That is why they may be subsidiary to receive nutritional therapy so as to improve their nutritional status and the transplant outcomes. However, preoperative support is difficult to perform in many cases due to multiple factors among which the patients clinical situation, the diagnostic requirements, the

  8. Trasplante óseo Bone transplant

    Directory of Open Access Journals (Sweden)

    M. San Julián

    2006-08-01

    .We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principally used in surgery to save tumour patients, in large post-traumatic reconstructions and in replacement surgery where there are massive bone defects and a structural support is required. The spongy grafts are the most used due to their numerous indications; they are especially useful in filling cavities that require a significant quantity of graft when the autograft is insufficient, or as a complement. They are also of special help in treating fractures when there is bone loss and in the treatment of delays in consolidation and pseudoarthrosis in little vascularized and atrophic zones. They are also used in prosthetic surgery against the presence of cavity type defects. Allografts of soft tissues are specially recognised in multiple ligament injuries that require reconstructions. Nowadays, the most utilised are those employed in surgery of the anterior cruciate ligament although they can be used for filling any ligament or tendon defect. The principal difficulties of the cortical allografts are in the consolidation of the ends with the bone itself and in tumour surgery, given that these are patients immunodepressed by the treatment, the incidence of infection is increased with respect to spongy grafts and soft tissues, which is irrelevant. In short, the increasingly widespread use of allografts is an essential therapeutic weapon in orthopaedic surgery and traumatology. It must be used by expert hands.

  9. The H2BK123Rgument

    OpenAIRE

    Latham, John A.; Dent, Sharon Y. R.

    2009-01-01

    The discovery of trans-regulation of histone H3K4 methylation by ubiquitination of histone H2BK123 generated much excitement in the field of chromatin biology. Recently, the veracity of this example of cross talk between histone modifications in yeast was challenged (Foster and Downs, 2009. J. Cell Biol. doi:10.1083/jcb.200812088) but ultimately reconfirmed in a study in this issue (Nakanishi et al., 2009. J. Cell Biol. doi:10.1083/jcb.200906005).

  10. Exposing the Molecular Machinery of BK Polyomavirus.

    Science.gov (United States)

    Buck, Christopher B

    2016-04-01

    BK polyomavirus (BKV) is an opportunistic pathogen that poses a serious threat to organ transplant recipients. In this issue of Structure, Hurdiss and colleagues' (Hurdiss et al., 2016) beautiful new high-resolution cryo-EM reconstruction of BKV provides a structural roadmap for the ongoing development of therapeutic antibodies and vaccines targeting this potentially deadly virus. The study also serves as a platform for exploring the basic biology of virion assembly and infectious entry. PMID:27050683

  11. Transient versus Persistent BK Viremia and Long-Term Outcomes after Kidney and Kidney–Pancreas Transplantation

    Science.gov (United States)

    Elfadawy, Nissreen; Schold, Jesse D.; Srinivas, Titte R.; Poggio, Emilio; Fatica, Richard; Avery, Robin; Mossad, Sherif B.

    2014-01-01

    Background and objectives The objective was to study the long-term impact of transient versus persistent BK viremia on kidney transplant outcomes. Design, setting, participants, & measurements In total, 609 recipients who underwent kidney transplant from 2007 to 2011 were screened at months 1–12 for the occurrence of polyomavirus BK viremia; 130 patients (21.7%) developed BK viremia during the first year post-transplant. BK viremia patients were classified according to duration of infection (more or less than 3 months), and BK viral loads (more or less than 10,000 copies/ml) were classified as transient low viremia (n=42), transient high viremia (n=18), persistent low viremia (n=23), and persistent high viremia (n=47). All patients were followed a median of 36 (3–66) months. The rates of BK polyomavirus–associated nephropathy, acute rejection, and 1-year graft function were compared with the polyomavirus BK–negative control group. Results Patient and graft survival were not significantly different among the groups. Graft function (creatinine; milligrams per deciliter) at 1 year was significantly worse in the persistent high viremia (1.75±0.6) and transient high viremia (1.85±0.7) groups compared with aviremic controls (1.47±0.4; P=0.01 and P=0.01, respectively). The incidence of BK polyomavirus–associated nephropathy was limited to the persistent high viremia group (1.3%, P<0.001). The transient high viremia (50%) and persistent high viremia (34%) groups showed significantly (P=0.01) increased incidence of acute rejection versus aviremic controls (21.5%), transient low viremia (19%), or persistent low viremia (17.3%) groups. Conclusion Low viral load BK viremia, either transient or persistent, was not associated with long-term transplant outcomes. Persistent high viremia was associated with a greater risk for BK polyomavirus–associated nephropathy and subsequent graft dysfunction. Although transient high viremia was not associated with BK

  12. Nuevas fronteras en el trasplante de progenitores hematopoyéticos: el trasplante de células de cordón umbilical, una realidad en el tratamiento de Pacientes Adultos con Leucemia

    OpenAIRE

    Sanz, Miguel A.

    2006-01-01

    Los continuos avances en el trasplante alogénico de progenitores hematopoyéticos no sólo han mejorado los resultados clínicos en una variedad de enfermedades malignas y no malignas, sino que también han ampliado las indicaciones de tales trasplantes.

  13. Nuevas fronteras en el trasplante de progenitores hematopoyéticos: el trasplante de células de cordón umbilical, una realidad en el tratamiento de Pacientes Adultos con Leucemia

    Directory of Open Access Journals (Sweden)

    Miguel A. Sanz

    2006-04-01

    Full Text Available Los continuos avances en el trasplante alogénico de progenitores hematopoyéticos no sólo han mejorado los resultados clínicos en una variedad de enfermedades malignas y no malignas, sino que también han ampliado las indicaciones de tales trasplantes.

  14. Silicosis y trasplante pulmonar Lung transplantation in silicosis

    Directory of Open Access Journals (Sweden)

    MARÍA TERESA PARADA C

    2007-06-01

    Full Text Available La silicosis es una enfermedad prevalente en Chile, que es un país minero y en desarrollo. Existe escasa bibliografía sobre trasplante pulmonar, como alternativa de tratamiento en silicosis avanzada. Objetivo: Describir el tiempo y forma de exposición a la sílice y las características clínicas de enfermos silicóticos tratados con trasplante pulmonar en la Clínica Las Condes de Santiago. Pacientes y Métodos: De un total de 38 pacientes en los que se practicó trasplante pulmonar entre 1999 y 2006, cuatro de ellos fueron trasplantados por padecer de silicosis avanzada. En estos 38 enfermos la fibrosis pulmonar idiopática fue la enfermedad subyacente predominante (55%. Resultados: Los 4 pacientes silicóticos fueron trasplantados a una edad que fluctuó entre 34 y 65 años. Su período de exposición varió entre 5 y 30 años y sus síntomas comenzaron a manifestarse 4 a 30 años después de iniciada la exposición. Dos pacientes eran mineros, otro trabajó en la molienda de cuarzo y el 4º enfermo fue pulidor de prótesis dentales. La cirugía fue compleja debido a la distorsión de la anatomía pulmonar de estos enfermos. La estadía hospitalaria fue más prolongada en los trasplantados silicóticos que en los no silicóticos (41 versus 21 días, p Silicosis is a prevalent disease in Chile, a developing miner country. Scarce information about lung transplantation as an alternative for treating severe silicosis is available. Objective: To describe the time and way of exposure to silica and the clinical characteristics of silicotic patients subjected to lung transplantation at Clinica Las Condes, Santiago. Patients and Methods: From 38 patients subjected to lung transplantation between 1999 and 2006, four of them were transplanted because of severe silicosis. Ldiopathic pulmonary fibrosis was the predominant underlying disease (55% of these 38 patients. Results: The four silicotic patients were transplanted at an age ranging from 34 to 65

  15. Viviendo con los pacientes el sueño del trasplante: una experiencia enfermera

    Directory of Open Access Journals (Sweden)

    Ana Julia Carrillo Algarra

    2014-06-01

    Full Text Available El trasplante renal puede ser una solución para personas que sufren insuficiencia renal crónica. Durante este proceso es de vital importancia el cuidado de enfermería en las diferentes etapas a las que el paciente y su familia se ven enfrentados. Este es el relato biográfico de una enfermera con amplia experiencia en el cuidado de pacientes que han vivido el trasplante renal, que describe diferentes aspectos que se deben tener en cuenta en la relación del equipo interdisciplinario, con el paciente y la familia; a través del mismo narra las vivencias y los sentimientos que afloran en el diario vivir de su labor y comenta su opinión respecto al futuro de la Enfermería en trasplantes.

  16. An Echo of Supernova 2008bk

    CERN Document Server

    Van Dyk, Schuyler D

    2013-01-01

    I have discovered a prominent light echo around the low-luminosity Type II-Plateau Supernova (SN) 2008bk in NGC 7793, seen in archival images obtained with the Wide Field Channel of the Advanced Camera for Surveys on-board the Hubble Space Telescope (HST). The echo is a partial ring, brighter to the north and east than to the south and west. The analysis of the echo I present suggests that it is due to the SN light pulse scattered by a sheet, or sheets, of dust located ~15 pc from the SN. The composition of the dust is assumed to be of standard Galactic diffuse interstellar grains. The visual extinction of the dust responsible for the echo is A_V ~ 0.05 mag, in addition to the extinction due to the Galactic foreground toward the host galaxy. That the SN experienced much less overall extinction implies that it is seen through a less dense portion of the interstellar medium in its environment. The late-time HST photometry of SN 2008bk also clearly demonstrates that the progenitor star has vanished.

  17. La economía de los trasplantes de organos: Los incentivos importan

    OpenAIRE

    Julio J. Elías

    2014-01-01

    El problema del faltante de órganos para trasplantes es grave en la mayoría de los países con programas desarrollados de trasplantes. En este ensayo resumo la investigación sobre el problema del faltante de órganos que desarrollamos de forma conjunta con Gary Becker de la Universidad de Chicago. Primero muestro la causa principal del faltante de órganos y el costo que impone el sistema actual sobre aquellos que esperan por un órgano. Luego presento una propuesta que desarrollamos con Gary Bec...

  18. El Lung Allocation Score como modelo predictivo de morbimortalidad en el trasplante pulmonar

    OpenAIRE

    Ojanguren Arranz, Amaia

    2012-01-01

    CONTEXTO: El trasplante pulmonar es a día de hoy una alternativa terapéutica válida para los pacientes en insuficiencia respiratoria crónica. Actualmente las indicaciones superan con creces el número de órganos disponibles lo que genera tiempos de espera prolongados. En el año 2005 Estados Unidos implementó un sistema innovador para priorizar los candidatos de la lista de espera mediante un estimador que calcula el beneficio neto que supondría realizar un trasplante pulmonar. Para ello se rea...

  19. BIOÉTICA, TRASPLANTE DE ÓRGANOS Y DERECHO PENAL EN COLOMBIA

    OpenAIRE

    Guerra, Yolanda Margaux

    2014-01-01

    Este artículo presenta los lineamientos del Derecho Penal que trascienden los conceptos de trasplantes de órganos y las implicaciones Bioéticasde los mismos. Del mismo modo, se establecen algunos de los principales criterios relacionados con el debate bioético en torno al problema de laDonación y Trasplante de Órganos, problemas relacionados con temas como la Muerte Encefálica, el consentimiento informado, Justicia y Distribución, los Xenotrasplantes y la Clonación Embrionaria, entre otros. L...

  20. Trasplante cardiaco en Asturias: epidemiología, resultados a medio y largo plazo. Impacto de los nuevos inmunosupresores

    OpenAIRE

    Lambert Rodríguez, José Luis

    2012-01-01

    A punto de cumplirse 45 años del primer trasplante realizado por el Dr. Christian Barnard en Ciudad del Cabo, este procedimiento terapéutico se ha consolidado como el único capaz de cambiar de forma incontestable la historia natural de la insuficiencia cardiaca en fase terminal. En el presente trabajo estudiamos la historia y situación del trasplante cardiaco en Asturias, desde su inicio hasta la actualidad, para lo cual, después de una revisión histórica del trasplante y un...

  1. Indicaciones y oportunidad del trasplante hepático

    Directory of Open Access Journals (Sweden)

    Andrés E Ruf

    2008-01-01

    Full Text Available El trasplante hepático (TH está indicado en pacientes con enfermedades hepáticas agudas o crónicas severas e irreversibles para las cuales no exista un tratamiento alternativo y en ausencia de contraindicaciones. Las indicaciones de TH pueden ser agrupadas en cuatro categorías: cirrosis hepática, hepatitis fulminante, tumores hepáticos y defectos genéticos de origen hepático que producen daño en otros órganos. Deben ser derivados para TH los pacientes con cirrosis que desarrollen cualquier complicación mayor o coagulopatía. La derivación precoz es "la clave del éxito" en la hepatitis fulminante por el alto riesgo de muerte y por tener una evolución mayormente impredecible. La oportunidad del TH es el momento en la historia natural de la hepatopatía cuando la sobrevida esperada es mayor con TH que en lista de espera. Estudios recientes han sugerido que el máximo beneficio del TH se obtiene en pacientes con MELD >15. Sin embargo, en algunos casos sin riesgo de muerte inminente, el objetivo del TH es mejorar la calidad de vida o prevenir contraindicaciones como la progresión del hepatocarcinoma cuando el tiempo de espera excede los 8 meses. Actualmente existe una marcada desproporción entre el número de donantes disponibles y el número creciente de potenciales receptores, lo que ha determinado un incremento progresivo del tiempo y mortalidad en lista. La racionalidad de distribuir los órganos en base al score de MELD es otorgar prioridad en la lista a los candidatos más enfermos y a aquellos que no pueden esperar como los pacientes con hepatocarcinoma.

  2. El cuidado en un programa de trasplante renal: un acompañamiento de vida

    Directory of Open Access Journals (Sweden)

    Ana Julia Carrillo-Algarra

    2015-01-01

    Full Text Available Objetivo: comprender las experiencias de cuidado de enfermeras integrantes de grupos de trasplante de la ciudad de Bogotá. Materiales y métodos: investigación cualitativa, utilizó la estrategia de grupos focales; la organización y el análisis de datos siguieron la propuesta de codificación de Janice M. Morse; participaron, previo consentimiento informado, 10 de 20 enfermeras de unidades de trasplante. Se realizó triangulación entre las integrantes del equipo investigador y la literatura relevante. Resultados: emergieron 6 ca- tegorías: 1 los múltiples significados del trasplante: cambio, pasión, satisfacción, esperanza, libertad, mayor cercanía, responsabilidad, compromiso, complejidad; 2 las redes de apoyo: familia, asociación de enfermeras, grupo de trabajo interdisciplinario, empresas pro- motoras de salud, industria farmacéutica; 3 implicaciones del día a día: relación cercana con el paciente y la familia, fortalecimiento de la autoestima profesional, estatus dentro del grupo de trasplante, manejo de las cargas; 4 trayectorias del cuidado profesiona l: acom- pañamiento de la enfermera a través del ciclo vital del paciente y posibilidad de identificar necesidades por la estrecha relac ión con él; 5 el perfil de la enfermera: carácter, conocimiento, compromiso, disponibilidad permanente y capacidad de gestión; 6 contradi cciones del trasplante: rechazo al injerto, sufrimiento, desesperanza, sistema de salud; para enfermería, las agotadoras jornadas de tr abajo.

  3. Address Points, areas-bk, Published in 2005, Daggett County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, was produced all or in part from Other information as of 2005. It is described as 'areas-bk'. Data by this publisher are often provided...

  4. BK polyomavirus association with colorectal cancer development.

    Science.gov (United States)

    Khabaz, M N; Nedjadi, T; Gari, M A; Al-Maghrabi, J A; Atta, H M; Basuni, A A; Elderwi, D A

    2016-01-01

    The development of human neoplasms can be provoked by exposure to one of several viruses. Burkitt lymphoma, cervical carcinoma, and hepatocellular carcinoma are associated with Epstein-Barr, human papilloma, and hepatitis B virus infections, respectively. Over the past three decades, many studies have attempted to establish an association between colorectal cancer and viruses, with debatable results. The aim of the present research was to assess the presence of BK polyomavirus (BKV) DNA and protein in colorectal cancer samples from patients in the Western Province of Saudi Arabia. DNA extracted from archival samples of colorectal cancer tissues was analyzed for BKV sequences using polymerase chain reaction (PCR)-based techniques. In addition, expression of a BKV protein was assessed using immunohistochemical staining. None of the tumor and control samples examined tested positive for BKV DNA in PCR assays. Furthermore, immunohistochemical staining failed to detect viral proteins in both cancer and control specimens. These results may indicate that BKV is not associated with the development of colorectal adenocarcinoma in patients in the Western Province of Saudi Arabia. PMID:27173319

  5. BK Polyomavirus Infection and Renourinary Tumorigenesis.

    Science.gov (United States)

    Papadimitriou, J C; Randhawa, P; Rinaldo, C Hanssen; Drachenberg, C B; Alexiev, B; Hirsch, H H

    2016-02-01

    BK polyomavirus (BKPyV) infection represents a major problem in transplantation, particularly for renal recipients developing polyomavirus-associated nephropathy (PyVAN). The possibility that BKPyV may also be oncogenic is not routinely considered. Twenty high-grade renourinary tumors expressing polyomavirus large T antigen in the entirety of the neoplasm in 19 cases, including the metastases in six, have been reported in transplant recipients with a history of PyVAN or evidence of BKPyV infection. Morphological and phenotypical features consistent with inactivation of the tumor suppressors pRB and p53 were found in the bladder tumors, suggesting a carcinogenesis mechanism involving the BKPyV large tumor oncoprotein/antigen. The pathogenesis of these tumors is unclear, but given the generally long interval between transplantation and tumor development, the risk for neoplasms after BKPyV infections may well be multifactorial. Other elements potentially implicated include exposure to additional exogenous carcinogens, further viral mutations, and cell genomic instability secondary to viral integration, as occurs with the Merkel cell PyV-associated carcinoma. The still scarce but increasingly reported association between longstanding PyVAN and renourinary neoplasms requires a concerted effort from the transplant community to better understand, diagnose, and treat the putative association between the BKPyV and these neoplasms. PMID:26731714

  6. Diabetes y trasplante de páncreas Diabetes and pancreas transplantation

    Directory of Open Access Journals (Sweden)

    E. Esmatjes Mompó

    2008-05-01

    Full Text Available La nefropatía es una grave y frecuente complicación de la diabetes, cuyo tratamiento, en una fase terminal, implica la necesidad de efectuar diálisis, y de ser posible, un trasplante renal. El trasplante simultáneo de riñón y páncreas se considera en la actualidad como el tratamiento de elección en los pacientes con diabetes mellitus tipo 1 e insuficiencia renal terminal si no existe una contraindicación. El trasplante de páncreas es un procedimiento complejo, inicialmente asociado a una mayor morbilidad que el trasplante de riñón aislado, pero con el que hoy en día se obtiene una buena supervivencia del paciente y de los injertos. Esto implica una total normalización del control metabólico, permitiendo que el paciente desarrolle una vida normal sin necesidad de administrarse insulina, con los consiguientes beneficios que todo ello tiene para su calidad de vida y para la evolución de las complicaciones de la enfermedad. El trasplante de páncreas aislado, ofrece unos resultados algo peores a los del trasplante combinado de páncreas y riñón. No obstante, son lo suficientemente satisfactorios como para que se considere como una buena opción de tratamiento en pacientes portadores de un trasplante de riñón previo. Otra cuestión, es el trasplante de páncreas aislado en pacientes diabéticos sin insuficiencia renal y no trasplantados de riñón previamente. A pesar que sería el trasplante ideal, hoy en día, quedaría restringido a pacientes con una diabetes lábil, que precisan de repetidos ingresos hospitalarios por descompensación metabólica y/o episodios hipoglicémicos severos que se acompañan de pérdida de conciencia.Kidney disease is a severe and frequent complication in diabetes. In the terminal phase, treatment requires dialysis and, if possible, kidney transplantation. Provided that there are no contraindications, simultaneous kidney/pancreas transplantation is currently considered the treatment of choice in

  7. Polyomavirus BK infection in blood and marrow transplant recipients

    OpenAIRE

    Dropulic, LK; Jones, RJ

    2007-01-01

    The association of BK virus infection with hemorrhagic cystitis in blood and marrow transplant (BMT) recipients was first demonstrated two decades ago. During this time, therapeutic interventions focused on supportive measures such as hyperhydration, continuous bladder irrigation and topical administration of agents that alter the mucosal surface of the bladder wall. In recent years, PCR amplification of viral DNA in the urine and plasma has solidified the association of BK virus infection wi...

  8. Universal features of JIMWLK and BK evolution at small x

    OpenAIRE

    Rummukainen, Kari; Weigert, Heribert

    2003-01-01

    In this paper we present the results of numerical studies of the JIMWLK and BK equations with a particular emphasis on the universal scaling properties and phase space structure involved. The results are valid for near zero impact parameter in DIS. We demonstrate IR safety due to the occurrence of a rapidity dependent saturation scale Q_s(\\tau). Within the set of initial conditions chosen both JIMWLK and BK equations show remarkable agreement. We point out the crucial importance of running co...

  9. Polyomavirus specific cellular immunity: from BK-virus-specific cellular immunity to BK-virus-associated nephropathy ?

    Directory of Open Access Journals (Sweden)

    manon edekeyser

    2015-06-01

    Full Text Available In renal transplantation, BK-virus-associated nephropathy has emerged as a major complication, with a prevalence of 5–10% and graft loss in >50% of cases. BK-virus is a member of the Polyomavirus family and rarely induces apparent clinical disease in the general population. However, replication of polyomaviruses, associated with significant organ disease, is observed in patients with acquired immunosuppression, which suggests a critical role for virus-specific cellular immunity to control virus replication and prevent chronic disease. Monitoring of specific immunity combined with viral load could be used to individually assess the risk of viral reactivation and virus control. We review the current knowledge on BK-virus specific cellular immunity and, more specifically, in immunocompromised patients. In the future, immune-based therapies could allow us to treat and prevent BK-virus-associated nephropathy.

  10. Immunobiology of renal transplant Inmunología del trasplante renal historia de los trasplantes y del complejo mayor de histocompatibilidad

    Directory of Open Access Journals (Sweden)

    Jorge Eliécer Ossa Londoño

    1990-02-01

    Full Text Available

    This article reviews the development of organ transplantation from the early beginning when fiction and superstition prevailed, to the current times when, with the participation of surgeons, oncologists, geneticists and immunologists, the concept of the Major Histocompatibility Complex was developed and later on the complexity of these markers was worked out and was used to match Donors and Recipients thus making transplants feasible. Hopefully molecular biology will help to open a new era in transplantation to make this form of therapy more reliable and safely applicable to other organs.

    En este artículo se revisa el desarrollo de los trasplantes de órganos desde los primeros tiempos cuando prevalecían la ficción y la superstición, hasta la actualidad cuando, con la participación secuencial y sistemática de cirujanos, oncólogos, geneticistas e inmunólogos se descubrió el Complejo Mayor de Histocompatibilidad y más tarde se redujo la complejidad de estos marcadores hasta poderlos utilizar para el apareamiento Donador/Receptor y aumentar el éxito del trasplante. Se espera que la biología molecular ayude a abrir una nueva era en esta área para mejorar la eficiencia de esta forma de terapia y ampliar su uso a otros órganos.

  11. Universal features of JIMWLK and BK evolution at small x

    International Nuclear Information System (INIS)

    In this paper we present the results of numerical studies of the JIMWLK and BK equations with a particular emphasis on the universal scaling properties and phase space structure involved. The results are valid for near zero impact parameter in DIS. We demonstrate IR safety due to the occurrence of a rapidity-dependent saturation scale Qs(τ). Within the set of initial conditions chosen, both JIMWLK and BK equations show remarkable agreement. We point out the crucial importance of running coupling corrections to obtain consistency in the UV for both equations. Explicit studies of this have been performed with BK. Despite the scale breaking induced by the running coupling we find that evolution drives correlators towards an asymptotic form with near scaling properties. We discuss asymptotic features of the evolution, such as the τ- and A-dependence of Qs away from the initial condition

  12. Universal features of JIMWLK and BK evolution at small x

    Energy Technology Data Exchange (ETDEWEB)

    Rummukainen, Kari; Weigert, Heribert E-mail: heribert.weigert@physik.uni-regensburg.de

    2004-07-12

    In this paper we present the results of numerical studies of the JIMWLK and BK equations with a particular emphasis on the universal scaling properties and phase space structure involved. The results are valid for near zero impact parameter in DIS. We demonstrate IR safety due to the occurrence of a rapidity-dependent saturation scale Q{sub s}({tau}). Within the set of initial conditions chosen, both JIMWLK and BK equations show remarkable agreement. We point out the crucial importance of running coupling corrections to obtain consistency in the UV for both equations. Explicit studies of this have been performed with BK. Despite the scale breaking induced by the running coupling we find that evolution drives correlators towards an asymptotic form with near scaling properties. We discuss asymptotic features of the evolution, such as the {tau}- and A-dependence of Q{sub s} away from the initial condition.

  13. Coronary arterial BK channel dysfunction exacerbates ischemia/reperfusion-induced myocardial injury in diabetic mice.

    Science.gov (United States)

    Lu, Tong; Jiang, Bin; Wang, Xiao-Li; Lee, Hon-Chi

    2016-09-01

    The large conductance Ca(2+)-activated K(+) (BK) channels, abundantly expressed in coronary artery smooth muscle cells (SMCs), play a pivotal role in regulating coronary circulation. A large body of evidence indicates that coronary arterial BK channel function is diminished in both type 1 and type 2 diabetes. However, the consequence of coronary BK channel dysfunction in diabetes is not clear. We hypothesized that impaired coronary BK channel function exacerbates myocardial ischemia/reperfusion (I/R) injury in streptozotocin-induced diabetic mice. Combining patch-clamp techniques and cellular biological approaches, we found that diabetes facilitated the colocalization of angiotensin II (Ang II) type 1 receptors and BK channel α-subunits (BK-α), but not BK channel β1-subunits (BK-β1), in the caveolae of coronary SMCs. This caveolar compartmentation in vascular SMCs not only enhanced Ang II-mediated inhibition of BK-α but also produced a physical disassociation between BK-α and BK-β1, leading to increased infarct size in diabetic hearts. Most importantly, genetic ablation of caveolae integrity or pharmacological activation of coronary BK channels protected the cardiac function of diabetic mice from experimental I/R injury in both in vivo and ex vivo preparations. Our results demonstrate a vascular ionic mechanism underlying the poor outcome of myocardial injury in diabetes. Hence, activation of coronary BK channels may serve as a therapeutic target for cardiovascular complications of diabetes. PMID:27574914

  14. Impact of dietary intake and nutritional status on outcomes after liver transplantation Efecto de la ingesta y del estado nutricional en el trasplante hepático

    Directory of Open Access Journals (Sweden)

    D. A. de Luis

    2006-01-01

    nutritional status and dietary intake. Nutritional parameters showed no association with outcomes after liver transplantation. Liver transplantation improved serum protein levels and did not modify weight or dietary intake. Further studies are needed to clarify the role of liver transplantation on nutritional status and of nutritional status on liver transplantation outcomes, considering different populations of patients.Objetivo: el objetivo de nuestro estudio fue examinar de una manera prospectiva si la situación nutricional y la ingesta dietética pueden influir en los resultados del postrasplante hepático. Material y pacientes: se realizó una valoración nutricional basal y a los 6 meses en 31 pacientes consecutivos que fueron sometidos a trasplante hepático ortotópico (THO, en el Hospital U. Río Hortega. La evaluación nutricional incluyó el test de valoración subjetiva global (VSG, el test mininutritional assessment (MNA, antropometría convencional, analítica sérica y una encuesta nutricional de 3 días. Resultados: los pacientes tuvieron una edad media de 56,2 ± 8,11 años, peso (72,9 ± 15,3 kg e índice de masa corporal de (26,6 ± 4,1. La valoración antropométrica mostró los siguientes datos: pliegue tricipital 12,2 ± 6,1 mm, circunferencia muscular del brazo 24,5 ± 4,1 cm, masa libre de grasa 54,5 ± 10,9 kg, masa grasa 18,4 ± 6,5 mm y agua corporal 41,4 ± 9,1 kg. Tras seis meses del trasplante estos parámetros permanecieron inalterados. La ingesta calórica fue similar en el pre- y post-trasplante (28.1 ± 6 vs. 27,5 ± 5,8 kcal/kg: ns. Los niveles séricos de albúmina, prealbúmina y transferrina mejoraron a los 6 meses. La estancia media hospitalaria fue de 22,4 ± 14,9 días y la estancia en cuidados intensivos de 0,7 ± 1,7 días. EL estado nutricional determinado por los tests VSG y MNA no influyó en las estancias. Dos pacientes fallecieron tras el trasplante hepático (6,5% y 3 tuvieron rechazo agudo (9,6%. El estado nutricional

  15. Salud oral y patología bucodental en niños con trasplante hepático

    OpenAIRE

    Torres Moreta, Luz Angélica

    2015-01-01

    El trasplante hepático constituye hoy en día el único tratamiento definitivo para muchas de las enfermedades hepáticas graves, algunas de ellas mortales en un gran número de casos, como la Atresia de vías biliares, el Síndrome de Alagille, la colestasis familiar intrahepática, los tumores hepáticos, y otras enfermedades crónicas del hígado. El desarrollo de programas de trasplante hepático ha incrementado no sólo la supervivencia, sino también la mejora de la calidad de vida de estos paciente...

  16. Diffuse gastrointestinal bleeding and BK polyomavirus replication in a pediatric allogeneic haematopoietic stem cell transplant patient.

    Science.gov (United States)

    Koskenvuo, M; Lautenschlager, I; Kardas, P; Auvinen, E; Mannonen, L; Huttunen, P; Taskinen, M; Vettenranta, K; Hirsch, H H

    2015-01-01

    Patients undergoing haematopoietic stem cell transplantation (HSCT) are at high risk of severe gastrointestinal bleeding caused by infections, graft versus host disease, and disturbances in haemostasis. BK polyomavirus (BKPyV) is known to cause hemorrhagic cystitis, but there is also evidence of BKV shedding in stool and its association with gastrointestinal disease. We report putative association of BKPyV replication with high plasma viral loads in a pediatric HSCT patient developing hemorrhagic cystitis and severe gastrointestinal bleeding necessitating intensive care. The observation was based on chart review and analysis of BKPyV DNA loads in plasma and urine as well as retrospective BKPyV-specific IgM and IgG measurements in weekly samples until three months post-transplant. The gastrointestinal bleeding was observed after a >100-fold increase in the plasma BKPyV loads and the start of hemorrhagic cystitis. The BKPyV-specific antibody response indicated past infection prior to transplantation, but increasing IgG titers were seen following BKPyV replication. The gastrointestinal biopsies were taken at a late stage of the episode and were no longer informative of BK polyomavirus involvement. In conclusion, gastrointestinal complications with bleeding are a significant problem after allogeneic HSCT to which viral infections including BKPyV may contribute. PMID:25542476

  17. Biopsia Renal en receptores de Trasplante Renal: cuidados de enfermería y complicaciones

    OpenAIRE

    Esther Sanz Izquierdo; Mª Teresa Alonso Torres; Carmen Mirada Ariet; Esther Franquet Barnils; Ana Palomino Martínez; Carme Facundo Molas

    2015-01-01

    Introducción: La biopsia renal percutánea es una herramienta fundamental para el manejo del paciente trasplantado renal. La prueba es primordial para detectar y/o prevenir cualquier disfunción en el injerto, siendo un procedimiento tanto diagnóstico como preconizador. Objetivo: Describir los cuidados de enfermería e identificar las complicaciones derivadas de la biopsia renal en los receptores de Trasplante Renal. Material y métodos: Estudio cuantitativo, descriptivo y transversal realizado e...

  18. Farmacocinética de los inhibidores de la calcineurina en trasplante pulmonar de adultos

    OpenAIRE

    Méndez Garrido, Alejandra

    2015-01-01

    Los inhibidores de la calcineurina son los fármacos fundamentales para el tratamiento inmunosupresor del trasplante pulmonar (TP). El manejo de estos fármacos se basa en la monitorización farmacocinética de los mismos, generalmente mediante estrategias de muestreo limitado. El impacto que tienen las variaciones farmacocinéticas en los resultados y cuál es la bioequivalencia entre distintas formas farmacéuticas de algunos de ellos son las preguntas de la presente tesis doctoral. Pacientes y...

  19. Puente a trasplante cardiaco con oxigenación de membrana extracorpórea

    OpenAIRE

    Torregrosa Puerta, Salvador

    2012-01-01

    PUENTE A TRASPLANTE CARDIACO CON OXIGENACIÓN DE MEMBRANA EXTRACORPÓREA Objetivos: Los nuevos sistemas de Oxigenación de Membrana Extracorpórea (ECMO) han presentado un desarrollo tecnológico notable, fundamentalmente debido a la incorporación de oxigenadores y bombas centrífugas de larga duración, lo cual ha conducido a una importante mejoría en la supervivencia de los pacientes en shock cardiogénico refractario tratados con este tipo de asistencia mecánica circulatoria de corta duración. ...

  20. Interacting influence of diuretics and diet on BK channel-regulated K homeostasis.

    Science.gov (United States)

    Wen, Donghai; Cornelius, Ryan J; Sansom, Steven C

    2014-04-01

    Large conductance, Ca-activated K channels (BK) are abundantly located in cells of vasculature, glomerulus, and distal nephron, where they are involved in maintaining blood volume, blood pressure, and K homeostasis. In mesangial cells and smooth muscle cells of vessels, the BK-α pore associates with BK-β1 subunits and regulates contraction in a Ca-mediated feedback manner. The BK-β1 also resides in connecting tubule cells of the nephron. BK-β1 knockout mice (β1KO) exhibit fluid retention, hypertension, and compromised K handling. The BK-α/β4 resides in acid/base transporting intercalated cells (IC) of the distal nephron, where they mediate K secretion in mammals on a high K, alkaline diet. BK-α expression in IC is increased by a high K diet via aldosterone. The BK-β4 subunit and alkaline urine are necessary for the luminal expression and function of BK-α in mouse IC. In distal nephron cells, membrane BK-α expression is inhibited by WNK4 in in vitro expression systems, indicating a role in the hyperkalemic phenotype in patients with familial hyperkalemic hypertension type 2 (FHHt2). β1KO and BK-β4 knockout mice (β4KO) are hypertensive because of exaggerated epithelial Na channels (ENaC) mediated Na retention in an effort to secrete K via only renal outer medullary K channels (ROMK). BK hypertension is resistant to thiazides and furosemide, and would be more amenable to ENaC and aldosterone inhibiting drugs. Activators of BK-α/β1 or BK-α/β4 might be effective blood pressure lowering agents for a subset of hypertensive patients. Inhibitors of renal BK would effectively spare K in patients with Bartter Syndrome, a renal K wasting disease. PMID:24721651

  1. Función renal en pacientes pediátricos con trasplante alogénico de progenitores hematopoyéticos

    OpenAIRE

    Pedro Zambrano; María Angélica Wietstruck; Florencia de Barbieri; Daniela Carrillo

    2014-01-01

    Introducción: Los pacientes con trasplante de progenitores hematopoyéticos pueden evolucionar con algún grado de compromiso renal. El objetivo de este estudio descriptivo fue evaluar marcadores de injuria renal en pacientes pediátricos sometidos a trasplante alogénico de progenitores hematopoyéticos entre 1991 y 2011. Pacientes y Método: Estudio descriptivo en pacientes pediátricos con Trasplante alogénico de Precursores Hematopoyéticos entre los años 1991 y 2011 con edad entre 1 mes y 18 año...

  2. Genética de las complicaciones del trasplante de Células Madre Hematopoyéticas

    OpenAIRE

    José Domingo Torres Hernández

    2006-01-01

    El trasplante de células madre hematipoyéticas (TCMH) se efectúa cada vez con mayor frecuencia puesto que en muchas ocasiones es la única alternativa de tratamiento con posibilidad de curación en algunos desórdenes hematológicos.

  3. BK-parameter from Nf=2 twisted mass lattice QCD

    International Nuclear Information System (INIS)

    We present an unquenched Nf = 2 lattice computation of the BK parameter which controls K0- anti K0 oscillations. A partially quenched setup is employed with two maximally twisted dynamical (sea) light Wilson quarks, and valence quarks of both the maximally twisted and the Osterwalder-Seiler variety. Suitable combinations of these two kinds of valence quarks lead to a lattice definition of the BK parameter which is both multiplicatively renormalizable and O(a) improved. Employing the non-perturbative RI-MOM scheme, in the continuum limit and at the physical value of the pion mass we get BRGIK=0.729±0.030, a number well in line with the existing quenched and unquenched determinations. (orig.)

  4. Universal features of JIMWLK and BK evolution at small x

    CERN Document Server

    Rummukainen, K; Rummukainen, Kari; Weigert, Heribert

    2004-01-01

    In this paper we present the results of numerical studies of the JIMWLK and BK equations with a particular emphasis on the universal scaling properties and phase space structure involved. The results are valid for near zero impact parameter in DIS. We demonstrate IR safety due to the occurrence of a rapidity dependent saturation scale Q_s(\\tau). Within the set of initial conditions chosen both JIMWLK and BK equations show remarkable agreement. We point out the crucial importance of running coupling corrections to obtain consistency in the UV. Despite the scale breaking induced by the running coupling we find that evolution drives correlators towards an asymptotic form with near scaling properties. We discuss asymptotic features of the evolution, such as the \\tau- and A-dependence of Q_s away from the initial condition.

  5. [Cytomegalovirus and BK polyomavirus infection after renal transplantation].

    Science.gov (United States)

    De Paolis, P; Gervasio, E; Tedesco, M; Favaro', A; Iappelli, M; Di Giulio, S

    2009-01-01

    Cytomegalovirus (CMV) and BK polyomavirus (BKV) infections have been described in a high percentage of renal transplant patients and are known to cause various complications in renal transplantation. They are closely related to immunosuppressive therapy and implicated in the progression of graft failure. This review focuses on the clinical aspects of CMV and BKV infection after renal transplantation, optimal monitoring, and recent preventive measures and interventions to improve graft function and recipient survival. PMID:19382094

  6. Inhibition of Human BK Polyomavirus Replication by Small Noncoding RNAs

    OpenAIRE

    Tikhanovich, I.; Liang, B.; Seoighe, C.; et al.

    2011-01-01

    Small noncoding RNAs regulate a variety of cellular processes, including genomic imprinting, chromatin remodeling, replication, transcription, and translation. Here, we report small replication-regulating RNAs (srRNAs) that specifically inhibit DNA replication of the human BK polyomavirus (BKV) in vitro and in vivo. srRNAs from FM3A murine mammary tumor cells were enriched by DNA replication assay-guided fractionation and hybridization to the BKV noncoding control region (NCCR) and synthesize...

  7. Inhibition of Human BK Polyomavirus Replication by Small Noncoding RNAs▿

    OpenAIRE

    Tikhanovich, Irina; Liang, Bo; Seoighe, Cathal; Folk, William R.; Nasheuer, Heinz Peter

    2011-01-01

    Small noncoding RNAs regulate a variety of cellular processes, including genomic imprinting, chromatin remodeling, replication, transcription, and translation. Here, we report small replication-regulating RNAs (srRNAs) that specifically inhibit DNA replication of the human BK polyomavirus (BKV) in vitro and in vivo. srRNAs from FM3A murine mammary tumor cells were enriched by DNA replication assay-guided fractionation and hybridization to the BKV noncoding control region (NCCR) and synthesize...

  8. Urological management (medical and surgical) of BK-virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation

    OpenAIRE

    Nikhil Vasdev; Angela Davidson; Christian Harkensee; Mary Slatter; Andrew Gennery; Ian Willetts; Andrew Thorpe

    2013-01-01

    Aim: Haemorrhagic cystitis (HC) is uncommon and in its severe form potentially life threatening complication of Haematopoietic stem cell transplantation (HSCT) in children. We present our single centre experience in the urological management of this clinically challenging condition. Patients and Methods: Fourteen patients were diagnosed with BK-Virus HC in our centre. The mean age at diagnosis was 8.8 years (range, 3.2-18.4 years). The mean number of days post-BMT until onset of HC was 20.8 (...

  9. Diarrea aguda en trasplantes renales y reno-pancreáticos

    Directory of Open Access Journals (Sweden)

    Alberto A Carena

    2015-02-01

    Full Text Available La diarrea es una complicación frecuente y potencialmente grave del trasplante renal. Se describen aquí, en un estudio de corte transversal, las características epidemiológicas y microbiológicas de la diarrea aguda y persistente en pacientes internados con trasplante renal o reno-páncreas. Se incluyeron 52 pacientes internados en un hospital de la Ciudad de Buenos Aires, 42 (80.8% habían recibido un trasplante renal y 10 (19.2% reno-páncreas. La diarrea fue el motivo de ingreso en 34 casos (65.4%. La etiología de la diarrea pudo estudiarse en 50 pacientes: en 25 (50% no se arribó a un diagnóstico etiológico y en 18 (36% se constató diarrea con causa microbiológica específica: 3 (6% enfermedad por citomegalovirus, 6 (12% diarrea atribuida a citomegalovirus, 5 (10% a rotavirus y 4 (8% a Clostridium difficile. En 7 (14% la diarrea fue atribuida a fármacos (mofetil micofenolato y sirolimus. Aquellos con diarrea con causa microbiológica habían recibido recientemente inmunosupresores a altas dosis con mayor frecuencia que el resto (p = 0.048. Los pacientes con diarrea atribuida a fármacos recibían más frecuentemente mofetil micofenolato (p = 0.039. En 16 (30.8% se realizaron modificaciones de los inmunosupresores como medida terapéutica, y a 47 (90.4% se les indicó antibioticoterapia empírica. La mediana de duración de internación fue de 6 días y 7 pacientes (14.6% persistieron con diarrea al quinto día. Todos tuvieron resolución de la diarrea al alta y un tercio persistió con insuficiencia renal. La información de este estudio puede servir para mejorar las medidas preventivas, diagnósticas y terapéuticas en estos pacientes.

  10. BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle

    DEFF Research Database (Denmark)

    Layne, Jeffrey J; Nausch, Bernhard; Olesen, Søren-Peter;

    2009-01-01

    activation of BK channels has the converse effect of reducing UBSM excitability and contractility. Here, we have sought to investigate this possibility by using the novel BK channel opener NS11021. NS11021 (3 microM) caused an approximately threefold increase in both single BK channel open probability (P......Large-conductance Ca(2+)-activated potassium (BK) channels play an important role in regulating the function and activity of urinary bladder smooth muscle (UBSM), and the loss of BK channel function has been shown to increase UBSM excitability and contractility. However, it is not known whether......(o)) and whole cell BK channel currents. The frequency of spontaneous action potentials in UBSM strips was reduced by NS11021 from a control value of 20.9 + or - 5.9 to 10.9 + or - 3.7 per minute. NS11021 also reduced the force of UBSM spontaneous phasic contractions by approximately 50%, and this force...

  11. Mucormicosis gástrica en paciente diabética con trasplante hepático: Presentación de 1 caso Gastric mucormycosis in a female diabetic patient with liver transplant: A case report

    Directory of Open Access Journals (Sweden)

    Evelín E. Lara Molina

    2006-03-01

    Full Text Available Se presentó un caso de mucormicosis gástrica en una serie de 18 pacientes que han recibido trasplante hepático en un período de 2 años en este centro. Se trató de una paciente diabética tipo 2 de 57 años, con cirrosis hepática alcohólica estadio C de Child-Pugh. Se le realizó trasplante ortotópico de hígado sin complicaciones y se utilizó esquema inmunosupresor con prednisona, ciclosporina y azatioprina. Evolutivamente, se presentó episodio neurológico de excitación y después sepsis respiratoria por Acinetobacter sp y Pseudomona sp que llevaron al distrés y, posteriormente, al fallo múltiple de órganos, además de sangrado digestivo alto a los 6 d de evolución. La paciente falleció a los 13 d del trasplante. En la necropsia se encontraron hifas de Mucor en tejidos gástricos. Se realizó diagnóstico post mortem, en una paciente con factores predisponentes como diabetes mellitus, tratamiento inmunosupresor, y sepsis bacteriana asociada. Se corroboró que es el único caso de mucormicosis gástrica reportado entre 5 772 necropsias realizadas en este centro.A case of gastric mucormycosis in a series of 18 patients that have received liver transplant in a period of 2 years in this centre, was presented. She was a type II diabetic patient aged 57 with Child-Pugh stage C alcoholic liver cirrhosis. An orthotopic liver transplant was performed without complications and an immunosuppressive scheme with prednisone, cyclosporin, and azathioprine. Evolutively, she presented a neurological episode of excitement and then respiratory sepsis due to Acinetobacter sp and Pseudomona sp that led to distress and, later, to multiple organ failure, in addition to high digestive bleeding at 6 days of evolution. The patient died at 13 days of the transplant. Mucor's hyphas were found in the gastric tissues on the necropsy. Post mortem diagnosis was made in a patient with predisposing factors, such as diabetes mellitus, immunosuppressive treatment

  12. Unique Inner Pore Properties of BK Channels Revealed by Quaternary Ammonium Block

    OpenAIRE

    Li, Weiyan; Aldrich, Richard W.

    2004-01-01

    Potassium channels have a very wide distribution of single-channel conductance, with BK type Ca2+-activated K+ channels having by far the largest. Even though crystallographic views of K+ channel pores have become available, the structural basis underlying BK channels' large conductance has not been completely understood. In this study we use intracellularly applied quaternary ammonium compounds to probe the pore of BK channels. We show that molecules as large as decyltriethylammonium (C10) a...

  13. Pengaruh Sumber Karbon dan Nitrogen Terhadap Pertumbuhan dan Pembentukan Spora Bacillus sp. Bk17

    OpenAIRE

    Rachmi

    2014-01-01

    Study of the effect of carbon and nitrogen sources on the growth and sporulation of Bacillus sp. BK17 has been conducted. Bacillus sp. BK17 was cultured in broth medium containing different carbon and nitrogen sources, and incubated for 6 days. The highest growth of Bacillus sp. BK17 was obtained on molasses-tryptone medium incubated during 3 days and the lowest growth obtained on whey-sodium nitrate. The highest spore formation was also obtained from molasses-tryptone mediu...

  14. Reactivation of BK polyomavirus in patients with multiple sclerosis receiving natalizumab therapy.

    LENUS (Irish Health Repository)

    Lonergan, Roisin M

    2012-02-01

    Natalizumab therapy in multiple sclerosis has been associated with JC polyomavirus-induced progressive multifocal leucoencephalopathy. We hypothesized that natalizumab may also lead to reactivation of BK, a related human polyomavirus capable of causing morbidity in immunosuppressed groups. Patients with relapsing remitting multiple sclerosis treated with natalizumab were prospectively monitored for reactivation of BK virus in blood and urine samples, and for evidence of associated renal dysfunction. In this cohort, JC and BK DNA in blood and urine; cytomegalovirus (CMV) DNA in blood and urine; CD4 and CD8 T-lymphocyte counts and ratios in peripheral blood; and renal function were monitored at regular intervals. BK subtyping and noncoding control region sequencing was performed on samples demonstrating reactivation. Prior to commencement of natalizumab therapy, 3 of 36 patients with multiple sclerosis (8.3%) had BK viruria and BK reactivation occurred in 12 of 54 patients (22.2%). BK viruria was transient in 7, continuous in 2 patients, and persistent viruria was associated with transient viremia. Concomitant JC and CMV viral loads were undetectable. CD4:CD8 ratios fluctuated, but absolute CD4 counts did not fall below normal limits. In four of seven patients with BK virus reactivation, transient reductions in CD4 counts were observed at onset of BK viruria: these resolved in three of four patients on resuppression of BK replication. No renal dysfunction was observed in the cohort. BK virus reactivation can occur during natalizumab therapy; however, the significance in the absence of renal dysfunction is unclear. We propose regular monitoring for BK reactivation or at least for evidence of renal dysfunction in patients receiving natalizumab.

  15. Calcium-Activated Potassium (BK) Channels Are Encoded by Duplicate slo1 Genes in Teleost Fishes

    OpenAIRE

    Rohmann, Kevin N.; Deitcher, David L.; Bass, Andrew H.

    2009-01-01

    Calcium-activated, large conductance potassium (BK) channels in tetrapods are encoded by a single slo1 gene, which undergoes extensive alternative splicing. Alternative splicing generates a high level of functional diversity in BK channels that contributes to the wide range of frequencies electrically tuned by the inner ear hair cells of many tetrapods. To date, the role of BK channels in hearing among teleost fishes has not been investigated at the molecular level, although teleosts account ...

  16. Trasplante de progenitores hemopoyéticos Transplant of hemopoietic progenitors

    Directory of Open Access Journals (Sweden)

    J. J. Rifón

    2006-08-01

    Full Text Available En la segunda mitad del siglo XX el trasplante de progenitores hemopoyéticos ha pasado de ser un tratamiento desesperado con una alta incidencia de complicaciones que implicaba una elevada mortalidad, a ser un tratamiento curativo para miles de pacientes con neoplasias hematológicas y otras enfermedades. Desde entonces se han ampliado los conocimientos sobre las células madre hemopoyéticas, la sangre periférica ha sustituido a la médula ósea como fuente de progenitores, la sangre de cordón se ha establecido como fuente viable de progenitores, la realización de trasplantes no emparentados es una realidad para muchos pacientes. La mejora en los regímenes de acondicionamiento y la introducción de los regímenes no mieloablativos han disminuido las recaídas. Las nuevas técnicas diagnósticas y los nuevos tratamientos antimicrobianos han disminuido las complicaciones infecciosas y su mortalidad. Se han desarrollado los conocimientos en determinación de enfermedad mínima residual y el efecto antitumoral de los linfocitos del donante lo que ha permitido ampliar las indicaciones. Además, los nuevos conocimientos en la inmunobiología del trasplante han mejorado por un lado las opciones de controlar una de las principales complicaciones como es la enfermedad injerto contra huésped, y por otro un mejor aprovechamiento del efecto inmunoterápico del trasplante.In the second half of the XX century, the transplant of hemopoietic progenitors ceased to be a desperate treatment with a high incidence of complications implying a high mortality, and became a curative treatment for thousands of patients with hematological neoplasias and other diseases. Since then understanding of the hemopoietic stem cells has increased, peripheral blood has replaced bone marrow as a source of progenitors, cord blood has been established as a viable source of progenitors and the realisation of unrelated transplants is a reality for many patients. The improvement of

  17. Interacting influence of diuretics and diet on BK channel-regulated K homeostasis

    OpenAIRE

    Wen, Donghai; Cornelius, Ryan J.; Sansom, Steven C.

    2013-01-01

    Large conductance, Ca-activated K channels are abundantly located in cells of vasculature, glomerulus and distal nephron, where they are involved in maintaining blood volume, blood pressure and K homeostasis. In mesangial cells and smooth muscle cells of vessels, the BK-α pore associates with BK-β1 subunits and regulates contraction in a Ca-mediated feedback manner. The BK-β1 also resides in connecting tubule cells of the nephron. BK-β1 knockout mice (β1KO) exhibit fluid retention, hypertensi...

  18. Las complicaciones de la herida quirúrgica en el trasplante renal Complications of the surgical wound in kidney transplants

    Directory of Open Access Journals (Sweden)

    Mª Teresa Zudaire Arana

    2005-03-01

    Full Text Available Observamos un empeoramiento en la evolución de las heridas quirúrgicas en el postoperatorio del trasplante renal. El comienzo de este problema se presenta al inicio del tratamiento con rapamicina combinado con otros inmunosupresores que ya utilizábamos. Objetivo. Valorar si se corresponde con la observación de enfermería, que el empeoramiento en la evolución de la herida quirúrgica del postrasplante renal, está en relación con el uso de rapamicina como inmunosupresor, añadido a los habituales factores de riesgo. Material y método. Estudio epidemiológico observacional de cohortes retrospectivo. Se estudió a un total de 56 pacientes trasplantados en nuestra unidad, desde el año 1999 hasta el 2003. Se seleccionan 30 pacientes con la pauta habitual de inmunosupresión: corticoides, ciclosporina o tacrolimus, micofenolato mofetil, etc. y a 26 pacientes con similar tratamiento, pero asociado a la rapamicina. Resultados. La relación entre los días de exudado de la herida quirúrgica, en el postoperatorio de los pacientes del grupo tratado con rapamicina, es estadísticamente significativa en relación con el grupo que no lo toma, con una p = 0.016 (pWe note a worsening in the evolution of the surgical wounds in the post-operative kidney transplant. The problem starts at the beginning of treatment with rapamicin combined with other immunosuppressors we already used. Objective. To evaluate whether there is correspondence with the nursing observation that the poorer evolution of the postoperative surgical wound of kidney transplants are related to the use of rapamicin as an immunosuppressor, added to the habitual risk factors. Material and method. Retrospective observational epidemiological study of cohorts. A total 56 patients transplanted in our unit were studied from 1999 to 2003. Thirty patients were selected with the usual immunosuppression tendency: corticoids, cyclosporin or tacrolimus, mofethyl micophenolate, etc. and 26 patients

  19. Collinearly-improved BK evolution meets the HERA data

    Directory of Open Access Journals (Sweden)

    E. Iancu

    2015-11-01

    Full Text Available In a previous publication, we have established a collinearly-improved version of the Balitsky–Kovchegov (BK equation, which resums to all orders the radiative corrections enhanced by large double transverse logarithms. Here, we study the relevance of this equation as a tool for phenomenology, by confronting it to the HERA data. To that aim, we first improve the perturbative accuracy of our resummation, by including two classes of single-logarithmic corrections: those generated by the first non-singular terms in the DGLAP splitting functions and those expressing the one-loop running of the QCD coupling. The equation thus obtained includes all the next-to-leading order corrections to the BK equation which are enhanced by (single or double collinear logarithms. We then use numerical solutions to this equation to fit the HERA data for the electron–proton reduced cross-section at small Bjorken x. We obtain good quality fits for physically acceptable initial conditions. Our best fit, which shows a good stability up to virtualities as large as Q2=400 GeV2 for the exchanged photon, uses as an initial condition the running-coupling version of the McLerran–Venugopalan model, with the QCD coupling running according to the smallest dipole prescription.

  20. Collinearly-improved BK evolution meets the HERA data

    CERN Document Server

    Iancu, E; Mueller, A H; Soyez, G; Triantafyllopoulos, D N

    2015-01-01

    In a previous publication, we have established a collinearly-improved version of the Balitsky-Kovchegov (BK) equation, which resums to all orders the radiative corrections enhanced by large double transverse logarithms. Here, we study the relevance of this equation as a tool for phenomenology, by confronting it to the HERA data. To that aim, we first improve the perturbative accuracy of our resummation, by including two classes of single-logarithmic corrections: those generated by the first non-singular terms in the DGLAP splitting functions and those expressing the one-loop running of the QCD coupling. The equation thus obtained includes all the next-to-leading order corrections to the BK equation which are enhanced by (single or double) collinear logarithms. We then use numerical solutions to this equation to fit the HERA data for the electron-proton reduced cross-section at small Bjorken x. We obtain good quality fits for physically acceptable initial conditions. Our best fit, which shows a good stability ...

  1. Tumores malignos de novo en el trasplante hepático experiencia de un centro en la Argentina

    Directory of Open Access Journals (Sweden)

    Florencia Antinucci

    2015-02-01

    Full Text Available El objetivo del presente trabajo ha sido evaluar la incidencia y las características clínicas de los tumores aparecidos de novo en los pacientes sometidos a trasplante hepático, como así también su supervivencia. Para ello, analizamos en forma retrospectiva los 168 trasplantes hepáticos realizados en 159 pacientes adultos en el período mayo 2006 hasta mayo 2014, encontrando una incidencia de neoplasia de novo de 7.5% (n = 12. La edad media en el momento del diagnóstico fue de 63 ± 7 años. Las neoplasias más frecuentes fueron las de piel no melanoma y adenocarcinomas. El 50% de las neoplasias se desarrollaron en el segundo y tercer año postrasplante. El tipo de inmunosupresión no influyó en el tipo de tumor; sin embargo, debemos destacar que la mayor parte de los pacientes recibieron tacrolimus, micofenolato y/o corticoides. El tiempo medio de seguimiento tras el diagnóstico del tumor fue 25 ± 29 meses (0-76, y la tasa de mortalidad fue de un 41% (5/12 pacientes IC95%,15-72.La supervivencia global luego del trasplante a 1 y 5 años, calculada por análisis de Kaplan-Meier, fue de 83 y 55%, respectivamente. Los tumores de novo son frecuentes luego del trasplante hepático y presentan un patrón evolutivo diferente al de la población general. Teniendo en cuenta esta evolución más agresiva, es fundamental el seguimiento periódico en estos pacientes para realizar un diagnóstico lo más precoz posible.

  2. InterProScan Result: BK005919 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BK005919 BK005919_1_ORF1 CAA510C026AD7115 PANTHER PTHR21137 7tm6_olfct_rcpt 9.800002721303041E-2 ... t binding (GO:0005549)|Biological Process: sensory perception ... of smell (GO:0007608)|Cellular Component: membrane ...

  3. InterProScan Result: BK005919 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BK005919 BK005919_1_ORF1 CAA510C026AD7115 PFAM PF02949 7tm_6 6.900000000000011E-20 T IPR004117 O ... t binding (GO:0005549)|Biological Process: sensory perception ... of smell (GO:0007608)|Cellular Component: membrane ...

  4. Cochlear function in mice lacking the BK channel alpha, beta1, or beta4 subunits

    NARCIS (Netherlands)

    Pyott, Sonja J; Meredith, Andrea L; Fodor, Anthony A; Vázquez, Ana E; Yamoah, Ebenezer N; Aldrich, Richard W

    2007-01-01

    Large conductance voltage- and calcium-activated potassium (BK) channels are important for regulating many essential cellular functions, from neuronal action potential shape and firing rate to smooth muscle contractility. In amphibians, reptiles, and birds, BK channels mediate the intrinsic frequenc

  5. BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation.

    Science.gov (United States)

    Han, Seung Beom; Cho, Bin; Kang, Jin Han

    2014-12-01

    Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis, which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration. However, late-onset hemorrhagic cystitis, which is usually caused by the BK virus, continues to develop. Although the BK virus is the most common pathogenic microorganism of poststem cell transplantation late-onset hemorrhagic cystitis, pediatricians outside the hemato-oncology and nephrology specialties tend to be unfamiliar with hemorrhagic cystitis and the BK virus. Moreover, no standard guidelines for the early diagnosis and treatment of BK virus-associated hemorrhagic cystitis after stem cell transplantation have been established. Here, we briefly introduce poststem cell transplantation BK virus-associated hemorrhagic cystitis. PMID:25653684

  6. KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury

    DEFF Research Database (Denmark)

    Soltysinska, Ewa; Bentzen, Bo Hjorth; Barthmes, Maria;

    2014-01-01

    Mitochondrial potassium channels have been implicated in myocardial protection mediated through pre-/postconditioning. Compounds that open the Ca2+- and voltage-activated potassium channel of big-conductance (BK) have a pre-conditioning-like effect on survival of cardiomyocytes after ischemia....../reperfusion injury. Recently, mitochondrial BK channels (mitoBKs) in cardiomyocytes were implicated as infarct-limiting factors that derive directly from the KCNMA1 gene encoding for canonical BKs usually present at the plasma membrane of cells. However, some studies challenged these cardio-protective roles of mito......BKs. Herein, we present electrophysiological evidence for paxilline- and NS11021-sensitive BK-mediated currents of 190 pS conductance in mitoplasts from wild-type but not BK-/- cardiomyocytes. Transmission electron microscopy of BK-/- ventricular muscles fibres showed normal ultra-structures and matrix...

  7. Soporte social percibido y calidad de vida de personas con enfermedad renal crónica sometidas a trasplante renal

    Directory of Open Access Journals (Sweden)

    Judith Medellín Olaya

    2014-07-01

    Full Text Available Objetivo: Establecer la relación entre el soporte social y la calidad de vida percibida de personas con enfermedad renal crónica sometidas a trasplante renal. Método: Estudio descriptivo correlacional, de corte transversal y abordaje cuantitativo. Participaron 210 personas con trasplante renal que asistieron a su control mensual en una institución privada prestadora de servicios de salud. Se aplicaron los instrumentos Calidad de vida versión paciente de Betty Ferrell, Soporte social percibido de Hilbert y el Formato de caracterización sociodemográfica para persona con enfermedad crónica del Grupo de Cuidado al Paciente Crónico de la Universidad Nacional de Colombia. El análisis de asociación se realizó mediante la determinación de los coeficientes de correlación de Pearson y de Spearman, utilizando el programa SPSSS Versión 17.0 Resultados: Las características sociodemográficas de las personas con enfermedad renal crónica sometidas a trasplante renal fueron: mayoría hombres, edades entre 18 y 60 años, estado civil casados, estrato socioeconómico 2, nivel educativo bachillerato, ocupación trabajadores independientes. La percepción de calidad de vida en general fue alta, especialmente en la dimensión física. El soporte social percibido en la mayoría de los casos fue alto, reportándose los mayores puntajes en las dimensiones guía y en la interacción social, mientras que los menores, en la interacción personal. No se identificó correlación estadísticamente significativa entre calidad de vida y soporte social percibido en personas con enfermedad renal crónica sometidas a un trasplante renal. Conclusión: Para este estudio, la calidad de vida en personas sometidas a trasplante renal no se relacionó con el soporte social percibido, aspecto que puede estar relacionado con factores que requieren ser explorados mediante abordajes cualitativos que reconozcan elementos propios de la experiencia de cronicidad y que hacen

  8. Marcador Triangular, Método alternativo para la realización del trasplante manual en hileras en pequeñas parcelas.

    Directory of Open Access Journals (Sweden)

    Pedro Antonio Meneses Dartayet

    2007-01-01

    Full Text Available El trabajo se realizó en los campos experimentales de la Estación del Arroz “Sur del Jíbaro” y en áreas de producción del Arroz Popular de los municipios La Sierpe, Fomento y Taguasco, provincia de Sancti Spiritus. Se estudiaron cinco variantes para la realización del trasplante manual en hileras, las cuales fueron comparadas con el trasplante tradicional al Azar y entre ellas mismas; se evaluó la productividad (ha/hombre/jornada y el rendimiento agrícola (t/ha. Los resultados mostraron que la variante de mayor productividad fue el Trasplante Tradicional al Azar con 0.086 ha/hombre/jornada, en el resto de los tratamientos ésta se redujo hasta valores de 0.036, cuando se utilizó el marcador de dos sogas; por otra parte el rendimiento agrícola de todos los tratamientos donde se realizó el trasplante en hileras supero significativamente al trasplante tradicional al Azar, el mejor resultado fue alcanzado por el Marcador Triangular 20x20cm y 1.5 m de ancho.

  9. El trasplante en Navarra y España Transplantation in Navarra and Spain

    Directory of Open Access Journals (Sweden)

    J. J. Unzué

    2006-08-01

    Full Text Available La donación de órganos y tejidos es un proceso admitido en nuestra sociedad como algo habitual, así ante la inminencia de la muerte, y el planteamiento de la gravedad del paciente, en una UCI, la familia ofrece los órganos y/o tejidos antes de solicitarlos. Como cifra clave, al finalizar el año 2005, se produjeron tres datos históricos: por un lado, en España ha pasado de 35 donaciones por millón -¡récord mundial!-, y por otro lado, se ha conseguido la cifra más baja de negativas familiares de la historia, situándonos por debajo del 16 por millón, y además se ha podido rebasar la cifra de 1.500 donantes en un año. El hecho de llevar más de 30 años de experiencia en donación y trasplante ha permitido optimizar métodos y protocolos y distribuir con eficacia funciones sobre la base de la especialización; el Hospital de Navarra se encarga preferentemente de la extracción de órganos; el Hospital Virgen del Camino se ocupa de la captación de tejidos, y la Clínica Universitaria de Navarra del proceso quirúrgico del trasplante. En este trabajo se ofrecen datos de los distintos trasplantes haciendo referencia continuamente a los datos producidos entre los años 1995 y 2005; cuando la ocasión lo requiere, se citan también datos anteriores y se establecen algunas comparaciones con el resto de España y otros países.The donation of organs and tissues is accepted in our society as a normal process; thus it frequently happens that when, in the face of imminent death, we inform the family of the severity of the patient in an intensive care unit, they offer us the organs and/or tissues before they are even asked. That is to say that in our milieu the degree of awareness and generosity is very high. As a sort of magic figure, three historic events occurred at the end of 2005: on the one hand, Spain exceeded the figure of 35 donations per million - a world record; on the other hand, we obtained the lowest figure of family refusals in

  10. Covariance fitting of highly correlated $B_K$ data

    CERN Document Server

    Yoon, Boram; Jung, Chulwoo; Lee, Weonjong

    2011-01-01

    We present the reason why we use the diagonal approximation (uncorrelated fitting) when we perform the data analysis of highly correlated $B_K$ data on the basis of the SU(2) staggered chiral perturbation theory. Basically, the essence of the problem is that we do not have enough statistics to determine the small eigenvalues of the covariance matrix with a high precision. As a result, we have the smallest eigenvalue, which is smaller than the statistical error of the covariance matrix, corresponding to an unphysical eigenmode. We have applied a number of prescriptions available in the market such as the cutoff method and modified covariance matrix method. It turns out that the cutoff method is not a good prescription and the modified covariance matrix method is an even worse one. The diagonal approximation turns out to be a good prescription if the data points are somehow correlated and the statistics are relatively poor.

  11. Oxidative Stress and Maxi Calcium-Activated Potassium (BK Channels

    Directory of Open Access Journals (Sweden)

    Anton Hermann

    2015-08-01

    Full Text Available All cells contain ion channels in their outer (plasma and inner (organelle membranes. Ion channels, similar to other proteins, are targets of oxidative impact, which modulates ion fluxes across membranes. Subsequently, these ion currents affect electrical excitability, such as action potential discharge (in neurons, muscle, and receptor cells, alteration of the membrane resting potential, synaptic transmission, hormone secretion, muscle contraction or coordination of the cell cycle. In this chapter we summarize effects of oxidative stress and redox mechanisms on some ion channels, in particular on maxi calcium-activated potassium (BK channels which play an outstanding role in a plethora of physiological and pathophysiological functions in almost all cells and tissues. We first elaborate on some general features of ion channel structure and function and then summarize effects of oxidative alterations of ion channels and their functional consequences.

  12. Expression of BK Ca channels and the modulatory beta-subunits in the rat and porcine trigeminal ganglion

    DEFF Research Database (Denmark)

    Johansson, Helle Wulf; Hay-Schmidt, Anders; Poulsen, Asser Nyander; Klærke, Dan Arne; Olesen, Jes; Jansen-Olesen, Inger

    2009-01-01

    cerebral arteries. We hypothesize that BK(Ca) channel alpha- and beta-subunits are present in the rat and porcine trigeminal ganglion (TG) thus enabling a role in migraine. BK(Ca) channel mRNA was detected using reverse transcription polymerase chain reaction (RT-PCR) and in situ hybridization. BK...

  13. Fusion and quasifission dynamics in the reactions $^{48}$Ca+$^{249}$Bk and $^{50}$Ti+$^{249}$Bk using TDHF

    CERN Document Server

    Umar, A S; Simenel, C

    2016-01-01

    Background: Synthesis of superheavy elements (SHE) with fusion-evaporation reactions is strongly hindered by the quasifission (QF) mechanism which prevents the formation of an equilibrated compound nucleus and which depends on the structure of the reactants. New SHE have been recently produced with doubly-magic $^{48}$Ca beams. However, SHE synthesis experiments with single-magic $^{50}$Ti beams have so far been unsuccessful. Purpose: In connection with experimental searches for $Z=117,119$ superheavy elements, we perform a theoretical study of fusion and quasifission mechanisms in $^{48}$Ca,$^{50}$Ti+$^{249}$Bk reactions in order to investigate possible differences in reaction mechanisms induced by these two projectiles. Methods: The collision dynamics and the outcome of the reactions are studied using unrestricted time-dependent Hartree-Fock (TDHF) calculations as well as the density-constrained TDHF method to extract the nucleus-nucleus potentials and the excitation energy in each fragment. Results: Nucleu...

  14. Utilidad del MELD y el sodio pretrasplante en el pronóstico del trasplante hepático a corto plazo

    OpenAIRE

    Londoño Hurtado, Maria Carlota

    2011-01-01

    [spa] El MELD y el sodio sérico son factores pronósticos en la cirrosis, pero no queda claro su papel en la evaluación del pronóstico en lista de espera para trasplante hepático y en tras el mismo. El objetivo de la presente tesis doctoral es evaluar la utlidad del MELD y el sodio sérico en la valoración pronóstica del paicente cirrótico antes y después del trasplante hepático. En el primer estudio se incluyeron 308 pacientes en lista de espera para trasplante hepático durante un periodo de 5...

  15. CALIDAD DE VIDA RELACIONADA CON LA SALUD INFANTIL Y EL TRASPLANTE DE ÓRGANOS: UNA REVISIÓN DE LITERATURA

    Directory of Open Access Journals (Sweden)

    Elisa Kern de Castro

    2005-06-01

    Full Text Available En el presente artículo los autores revisan algunas cuestiones teóricas y estudios empíricos sobre la calidad de vida relacionada con la salud infantil, en especial en niños con enfermedades crónicas que necesitan trasplantes de órganos. Pocas investigaciones han sido realizadas sobre el tema hasta el momento. Sus resultados han mostrado que el trasplante mejora el bienestar físico pero no hay conclusiones definitivas sobre su relación con el bienestar psicológico. Se discute la necesidad de evaluar los efectos del trasplante de órganos pediátrico en cada fase evolutiva, en distintos órganos y en diversas culturas.

  16. [Effect of liver trasplantation on familial amyloidotic polyneuropathy (FAP) and its limt].

    Science.gov (United States)

    Ando, Yukio

    2011-11-01

    Familial amyloidotic polyneuropathy (FAP) is a hereditary intractable disease induced by mutated transthyretin (TTR). Since TTR is predominantly synthesized by liver, liver transplantation has been performed to halt the clinical symptoms of FAP in the worldwide. It has been well documented that liver transplantation could halt the progression of FAP manifestations. However, the surgery could not prevent ocular symptoms and in some cases, cardiopathy and neuroparthy progressed even after liver trasplantation. Quantitative analyses for changes in the amount of amyloid deposition and ratio of wild type and variant type of TTR for autopsy transplanted FAP cases revealed that the amount of amyloid deposition decreased in most of the organs, but in heart and lung, the amount increased even after liver transplantation. In those organs, the ratio of wild type to variant TTR increased. Since liver transplantation has several problems, we are now performing several new therapeutic researches for FAP, such as development of drug stabilizing tetrameric form of TTR, siRNA therapy to stop TTR production, and low molecular compounds for preventing misfolding of TTR. PMID:22277510

  17. Prophylaxis and treatment of hepatitis B infection in the setting of liver transplantation Profilaxis y tratamiento de la infección por el virus de la hepatitis B en relación con el trasplante hepático

    Directory of Open Access Journals (Sweden)

    Delia D'Avola

    2011-03-01

    Full Text Available Without any treatment, the prognosis of hepatitis B in liver transplant recipients is very poor. So, antiviral prophylaxis is very important in patients with hepatitis B who undergo liver transplantation. Before liver transplantation, a suppression of viral replication has to be achieved by nucleos(tide analogs. Drugs used in the prophylaxis of post-transplant hepatitis B include immunoglobulin against HBV and nucleos(tide analogs. Prophylaxis against graft infection must be based on the individual risk of recurrence. When prophylactic measures have failed and graft infection has occurred, treatment of recurrent hepatitis B may be based on the resistance profile of the virus and previous antiviral exposure. Finally, lamivudine seems to be very effective in the prevention of de novo hepatitis B in patients transplanted with a graft from an anti-HBc positive donor.La infección por el virus de la hepatitis B en los receptores de trasplante hepático tiene un pronóstico malo en ausencia de tratamiento farmacológico. Por ello, en los pacientes trasplantados por una hepatopatía por virus B, la profilaxis de esta infección es imprescindible. Antes del trasplante, debe intentarse suprimir la replicación viral con un análogo de nucleót(sidos. Tras el trasplante, la profilaxis de la recidiva de la hepatitis B se basa en el uso de los análogos de nucleót(sidos y la inmunoglobulina frente al virus de la hepatitis B; la pauta de profilaxis debe basarse en el riesgo de recidiva de la hepatitis B que tenga cada paciente. En el caso de que se produzca una hepatitis B tras el trasplante, el tratamiento con análogos de nucleót(sidos debe basarse en los estudios de resistencia. Por último, en los pacientes trasplantados que reciben un injerto de un donante antiHBc-positivo, la profilaxis con lamivudina parece ser muy eficaz.

  18. Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels

    DEFF Research Database (Denmark)

    Sørensen, Mads Vaarby; Sausbier, Matthias; Ruth, Peter;

    2010-01-01

    anion secretion and a smaller electrically opposing K(+) secretion. Using tissue from (i) BK wildtype (BK(+/+)) and knockout (BK(/)) and (ii) cystic fibrosis transmembrane regulator (CFTR) wildtype (CFTR(+/+)) and knockout (CFTR(/)) mice we were able to isolate the adrenaline-induced K(+) secretion. We...... found that adrenaline-induced K(+) secretion: (1) is absent in colonic epithelia from BK(/) mice, (2) is greatly up-regulated in mice on a high K(+) diet and (3) is present as sustained positive current in colonic epithelia from CFTR(/) mice. We identified two known C-terminal BK alpha-subunit splice...

  19. Bk and Cf chromatographic separation and 249Bk/248Cm and 249Cf/248Cm elemental ratios determination by inductively coupled plasma quadrupole mass spectrometry

    International Nuclear Information System (INIS)

    The French Atomic Energy Commission has carried out several experiments for the study of minor-actinide transmutation processes in high intensity thermal neutron flux. In this context a Cm sample enriched in 248Cm (97%) was irradiated in a thermal neutron flux at the High Flux Reactor (HFR) of the Laue-Langevin Institute (ILL). The precise and accurate determination of Cf isotope ratios and of 249Bk/248Cm and 249Cf/248Cm elemental ratios in the 248Cm irradiated sample is crucial for the calculation of actinide neutron capture cross-sections.This work describes an analytical procedure for the separation and the isotope ratio measurement of Bk and Cf in the irradiated sample.The Bk and Cf separation is based on a lanthanides separation protocol previously developed by the laboratory. Well-defined retention times for Bk and Cf were obtained by coupling the Ionic Chromatography (IC) with an ICP-QMS. All conditions of element separation by IC and the different steps of the analytical protocol in order to obtain the isotopic and elemental ratios are presented. Relative uncertainties of Cf isotopic ratios range from 0.3% to 0.5% and the uncertainty of the 249Bk/248Cm and 249Cf/248Cm elemental ratios are respectively 6.1% and 3.2%.This level of uncertainty for both isotopic and elemental ratios is in perfect agreement with the requirement for transmutation studies. (authors)

  20. Factores pronósticos de supervivencia en pacientes con cirrosis hepática evaluados para trasplante hepático

    OpenAIRE

    Samada Suárez, Marcia

    2009-01-01

    La cirrosis hepática se encuentra entre las 10 primeras causas de mortalidad en Cuba con una tendencia ascendente en los últimos 20 años, en los estadios avanzados de la enfermedad el trasplante hepático es la mejor opción terapéutica. En este estudio fueron evaluados 144 pacientes con cirrosis hepática como candidatos a trasplante, entre enero de 2004 a diciembre de 2006, se excluyeron los pacientes trasplantados y los portadores de tumores malignos. Se determinaron los factores pronósticos ...

  1. CALIDAD DE VIDA RELACIONADA CON LA SALUD INFANTIL Y EL TRASPLANTE DE ÓRGANOS: UNA REVISIÓN DE LITERATURA

    OpenAIRE

    Elisa Kern de Castro; Bernardo Moreno-Jiménez

    2005-01-01

    En el presente artículo los autores revisan algunas cuestiones teóricas y estudios empíricos sobre la calidad de vida relacionada con la salud infantil, en especial en niños con enfermedades crónicas que necesitan trasplantes de órganos. Pocas investigaciones han sido realizadas sobre el tema hasta el momento. Sus resultados han mostrado que el trasplante mejora el bienestar físico pero no hay conclusiones definitivas sobre su relación con el bienestar psicológico. Se discute la necesidad de ...

  2. Rentabilidad diagnóstica de la tomografía computarizada de alta resolución en la valoración previa al trasplante pulmonar.

    OpenAIRE

    Pérez Enguix, Daniel Bernardo

    2007-01-01

    RESUMEN OBJETIVOS: Establecer la rentabilidad diagnóstica de los estudios de tomografía computarizada de alta resolución (TCAR) en la valoración previa al trasplante pulmonar. MATERIAL Y METODOS: Se ha realizado un estudio prospectivo en el transcurso de dos años, sobre una población de 81 pacientes remitidos al hospital La Fe de Valencia como posibles candidatos a trasplante pulmonar y cardio-pulmonar. De esta población se ha seleccionado una muestra de 71 pacientes cuya indicaci...

  3. Esquizofrenia y trasplante hepático: reporte de un caso Schizophrenia and Liver Transplantation: Case Report

    Directory of Open Access Journals (Sweden)

    Diana Restrepo B

    2012-07-01

    Full Text Available Introducción: El trasplante hepático es un tratamiento disponible para numerosos pacientes con cirrosis hepática, que encuentran en este tratamiento una alternativa médica para mejorar la expectativa y la calidad de vida. La esquizofrenia paranoide es un trastorno psiquiátrico que afecta al 1% de la población general, que produce síntomas psicóticos y cuyo curso crónico, en algunos casos, deteriora significativamente todas las áreas de la vida. Objetivo: Discutir el caso clínico de una mujer a quien se le diagnostica esquizofrenia paranoide durante el protocolo de evaluación para trasplante hepático por cirrosis hepática. Métodos: Reporte de caso. Resultados: Se reporta el caso de una mujer de 47 años con cirrosis hepática, cuya única alternativa para mejorar la expectativa y calidad de vida era acceder a un trasplante hepático. Durante las evaluaciones de rutina por el grupo de trasplantes, el psiquiatra de enlace observa síntomas psicóticos de primer orden y documenta una historia de vida que confirma la presencia de una esquizofrenia paranoide. Discusión y conclusiones: La esquizofrenia paranoide es un trastorno psiquiátrico mayor que puede hacer parte de las comorbilidades médicas de los pacientes que requieren trasplante de hígado y que no constituye una contraindicación absoluta para su realización. En Colombia no se conocen casos similares de trasplante de hígado en pacientes con esquizofrenia. Este es un gran paso en el camino de vencer el estigma que la enfermedad mental impone a los pacientes y permitirles el acceso a la atención médica general que requieren.Introduction: Liver transplantation is a treatment available for many patients with liver cirrhosis who find in this treatment a way to improve life expectancy and quality of life. Paranoid schizophrenia affects 1% of the general population, produces psychotic symptoms, and runs a chronic course in some cases with significant deterioration in all areas

  4. Influencia de cuatro distancias de trasplante sobre el rendimiento agrícola del cultivar de arroz Amistad-82.

    Directory of Open Access Journals (Sweden)

    Alexander Calero Hurtado

    2012-04-01

    Full Text Available El trabajo consistió en comparar cuatro distancias de trasplante sobre el rendimiento agrícola del cultivar de arroz Amistad-82, durante la siembra de primavera de 2012, el trasplante se realizó de forma manual, sobre un suelo pardo sialítico carbonatado en la finca “La Rosita” perteneciente a la CCS “Heriberto Orellane”, en la provincia de Sancti Spíritus, se utilizó un diseño de bloques al azar, se tomaron posturas jóvenes de 18 días de germinadas, cuatro distancias de plantación 10x15, 15x15, 20x15 y 20x20 cm y una postura por sitio. Se evaluaron los indicadores productivos como el número de tallos, panículas por metro cuadrado, longitud de la panícula, granos por panículas, granos llenos y vanos por panículas, peso de 1000 granos, el rendimiento, así como las ganancias y los costos de producción. Los mejores resultados sobre el rendimiento agrícola del cultivar de arroz Amistad-82 lo alcanzaron las distancias de trasplante 10x15 y 20x15 cm, porque lograron rendimientos superiores a las distancias 15x15 y 20x20 cm, mayor cantidad de granos por panículas y mayores porcentajes de granos llenos por panículas y superaron también el peso en 1000 granos y las ganancias.

  5. EXPERIMENTACIÓN FETAL, TRASPLANTES, COSMÉTICA Y SU RELACIÓN CON EL ABORTO PROVOCADO

    OpenAIRE

    José Luis Redondo Calderón

    2012-01-01

    La generalización del aborto provocado da lugar a gran cantidad de células, tejidos y órganos que se emplean en diversos campos de la Medicina bien en investigación o en tratamientos. Entre ellos destacan la Cardiología, Hematología, Metabolismo, Embriología, Neurología, Inmunología, Oftalmología, Dermatología y Trasplantes. También implica a potenciadores del sabor y cosméticos. El utilitarismo ha propiciado que se multipliquen los bancos de células y tejidos procedentes de abortos provocado...

  6. Indicaciones, técnicas y resultados del trasplante de intestino delgado Indications, techniques and outcomes of small bowel transplant

    OpenAIRE

    M. López Santamaría; F. Hernández Oliveros

    2007-01-01

    Los resultados más recientes del trasplante intestinal (TI), con una supervivencia inmediata al procedimiento superior al 80% de los casos, y una gran proporción de supervivientes que consiguen autonomía digestiva completa y desempeñan actividades acordes con su edad, permiten considerar el TI como el tratamiento de elección en enfermos con fallo intestinal irreversible en los que es previsible una mala evolución con nutrición parenteral. El daño hepático asociado a la administración de nutri...

  7. Enfermedad Renal Crónica y trasplante renal: experiencias y superación de una estudiante de medicina

    OpenAIRE

    Ana Julia Carrillo Algarra; Fanny Moreno Rubio; Sandra Milena Buitrago

    2015-01-01

    Las personas con enfermedad renal crónica (ERC) en estado terminal ven el trasplante como esperanza de vida e independencia, les evita ir tres veces por semana a hemodiálisis o tener presente el horario para sus recambios. Describen este cambio como positivo, por tanto interesa comprender cómo vive esa transformación Kate, estudiante de último año de medicina a quien sorpresivamente le diagnostican ERC, el efecto que tiene este suceso en su confianza en la medicina occidental, que la lleva a ...

  8. BK channels in microglia are required for morphine-induced hyperalgesia.

    Science.gov (United States)

    Hayashi, Yoshinori; Morinaga, Saori; Zhang, Jing; Satoh, Yasushi; Meredith, Andrea L; Nakata, Takahiro; Wu, Zhou; Kohsaka, Shinichi; Inoue, Kazuhide; Nakanishi, Hiroshi

    2016-01-01

    Although morphine is a gold standard medication, long-term opioid use is associated with serious side effects, such as morphine-induced hyperalgesia (MIH) and anti-nociceptive tolerance. Microglia-to-neuron signalling is critically involved in pain hypersensitivity. However, molecules that control microglial cellular state under chronic morphine treatment remain unknown. Here we show that the microglia-specific subtype of Ca(2+)-activated K(+) (BK) channel is responsible for generation of MIH and anti-nociceptive tolerance. We find that, after chronic morphine administration, an increase in arachidonic acid levels through the μ-opioid receptors leads to the sole activation of microglial BK channels in the spinal cord. Silencing BK channel auxiliary β3 subunit significantly attenuates the generation of MIH and anti-nociceptive tolerance, and increases neurotransmission after chronic morphine administration. Therefore, microglia-specific BK channels contribute to the generation of MIH and anti-nociceptive tolerance. PMID:27241733

  9. Polyomavirus BK-specific immunity after kidney transplantation.

    Science.gov (United States)

    Comoli, Patrizia; Azzi, Alberta; Maccario, Rita; Basso, Sabrina; Botti, Gerardo; Basile, Giancarlo; Fontana, Iris; Labirio, Massimo; Cometa, Angela; Poli, Francesca; Perfumo, Francesco; Locatelli, Franco; Ginevri, Fabrizio

    2004-10-27

    Failure to mount or maintain a protective immune response may influence the development of polyomavirus BK (BKV)-associated nephropathy (PVAN). However, limited data are so far available on BKV-specific immunity after kidney transplantation. BKV-specific cellular immune response was retrospectively analyzed in kidney recipients with or without BKV infection/reactivation by measuring the frequency of interferon (IFN)-gamma-secreting cells in peripheral blood. Patients with BKV-active infection and good renal function (n=6) had a mean BKV-specific lymphocyte frequency 2 log lower than healthy controls and in the same range as BKV-seropositive recipients without active infection (n=7). Patients with PVAN (n=5) revealed undetectable levels of BKV-specific cells. However, two patients from the latter cohort treated with immunosuppression reduction showed the emergence of specific immunity, with IFN-gamma production in the same range as healthy controls. Our preliminary data suggest that lack of protective immunity toward BKV may favor the occurrence of BKV active infection and influence the progression to PVAN. PMID:15502726

  10. Froth characteristic of MIBC and BK-201 frothers%起泡剂MIBC和BK-201的浮选泡沫特性

    Institute of Scientific and Technical Information of China (English)

    曾培; 欧乐明; 冯其明; 李洪强; 张福亚

    2015-01-01

    选用非极性基结构不同的起泡剂MIBC和BK-201,利用自制的泡沫性能测试系统,在两相泡沫体系下,测定两相泡沫不同高度处的气泡直径、静压强、表观溢流速度,研究起泡剂对泡沫特征及夹带的影响.结果表明:增加起泡剂浓度,气泡的兼并行为受到抑制,气泡直径逐渐减小;当MIBC浓度超过75 mg/L、BK-201浓度超过150 mg/L时,兼并行为受到显著抑制,气泡直径基本保持不变.在相同的浓度下,相比MIBC,BK-201产生的泡沫气泡直径大、含液率低、水回收速率低.因而,微细粒脉石在BK-201所形成泡沫中夹带更弱,浮选选择性更好.%By using self-designed foam property testing system, two nonpolar base structure frothers, MIBC and BK-201 were chosen to study the influences of frothers on the foam characteristic and entrainment by measuring the bubble diameter, static pressure and apparent flooding velocity in the two-phase foam. The results show that bubble merger degree reduces and air bubble diameter decreases with increasing frothers concentration. When the concentrations of MIBC and BK-201 are more than 75 and 150 mg/L, respectively, the air bubble diameter basically remains unchanged because the merger behavior is dramatically depressed. Under the same concentration, BK-201 generates larger diameter bubble, lower liquid holdup and lower water recovery compared with MIBC. As a result, the foam entrainment of fine gangue is weaker and the selectivity of flotation is better when BK-201 is used.

  11. BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation

    OpenAIRE

    Han, Seung Beom; Cho, Bin; Kang, Jin Han

    2014-01-01

    Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis, which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration. However, late-onset hemorrhagic cystitis, which is usually caused by the BK virus, continues to develop. Although the BK virus is the most common pathogenic microorganism of poststem cell transplantation late-onset hemorrhagic cystitis, ...

  12. Trasplante de homoinjertos valvulares cardiacos y vasculares Cardiac and vascular homograft valves transplant

    Directory of Open Access Journals (Sweden)

    J. M. Herreros

    2006-08-01

    Full Text Available Los progresos en la manipulación de los tejidos humanos, el desarrollo de la criobiología, la cirugía cardiaca pediátrica, la imposibilidad de conseguir una prótesis valvular cardiaca ideal y el tratamiento quirúrgico de las infecciones cardiovasculares, han reintroducido el interés para utilizar los homoinjertos. Los donantes de estos homoinjertos pueden ser: a Donantes vivos: válvula aórtica y pulmonar del receptor de trasplante cardiaco; b Donantes multiorgánicos con el diagnóstico de muerte según criterios neurológicos, cuyo corazón es rechazado para trasplante cq ardiaco; c Donantes cadáveres con asistolia inferior a 8 horas. Los homoinjertos valvulares cardiacos son el sustituto de elección en las endocarditis valvulares aórticas, pacientes con contraindicación para la anticoagulación, reconstrucción del tracto de salida de ventrículo derecho, sustitución valvular aórtica en niños o adultos jóvenes mediante la operación de Ross y es una indicación opcional la sustitución valvular aórtica y/o la aorta ascendente en los pacientes con edad superior a 60 años. Aunque no hay series suficientemente amplias de homoinjertos como sustitutos arteriales, en cuanto a número de pacientes y tiempo de evolución, los resultados sugieren que se pueden beneficiar los pacientes con infección vascular, inmunodeprimidos o los pacientes complejos cuya técnica durante la intervención puede requerir la necesidad de un homoinjerto.The advances in the manipulation of human tissues, the development of cryobiology, paediatric cardiac surgery, the impossibility of obtaining an ideal prosthetic cardiac valve and the surgical treatment of cardiovascular infections have revived interest in the use of homografts. The donors of these homografts can be: a Live donors: aortic and pulmonary valve of the recipient of a heart transplant; b Multiorgan donors with a diagnosis of death according to neurological criteria, whose heart is rejected

  13. BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice.

    Science.gov (United States)

    Kreifeldt, Max; Le, David; Treistman, Steven N; Koob, George F; Contet, Candice

    2013-01-01

    Large conductance calcium-activated potassium (BK) channels play a key role in the control of neuronal activity. Ethanol is a potent activator of BK channel gating, but how this action may impact ethanol drinking still remains poorly understood. Auxiliary β subunits are known to modulate ethanol-induced potentiation of BK currents. In the present study, we investigated whether BK β1 and β4 subunits influence voluntary ethanol consumption using knockout (KO) mice. In a first experiment, mice were first subjected to continuous two-bottle choice (2BC) and were then switched to intermittent 2BC, which progressively increased ethanol intake as previously described in wildtype mice. BK β1 or β4 subunit deficiency did not affect ethanol self-administration under either schedule of access. In a second experiment, mice were first trained to drink ethanol in a limited-access 2BC paradigm. BK β1 or β4 deletion did not affect baseline consumption. Weeks of 2BC were then alternated with weeks of chronic intermittent ethanol (CIE) or air inhalation. As expected, a gradual escalation of ethanol drinking was observed in dependent wildtype mice, while intake remained stable in non-dependent wildtype mice. However, CIE exposure only produced a mild augmentation of ethanol consumption in BK β4 KO mice. Conversely, ethanol drinking increased after fewer CIE cycles in BK β1 KO mice than in wildtype mice. In conclusion, BK β1 or β4 did not influence voluntary ethanol drinking in non-dependent mice, regardless of the pattern of access to ethanol. However, deletion of BK β4 attenuated, while deletion of BK β1 accelerated, the escalation of ethanol drinking during withdrawal from CIE. Our data suggest that BK β1 and β4 subunits have an opposite influence on the negative reinforcing properties of ethanol withdrawal. Modulating the expression, distribution or interactions of BK channel auxiliary subunits may therefore represent a novel avenue for the treatment of alcoholism

  14. BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice

    Directory of Open Access Journals (Sweden)

    Max eKreifeldt

    2013-12-01

    Full Text Available Large conductance calcium-activated potassium (BK channels play a key role in the control of neuronal activity. Ethanol is a potent activator of BK channel gating, but how this action may impact ethanol drinking still remains poorly understood. Auxiliary β subunits are known to modulate ethanol-induced potentiation of BK currents. In the present study, we investigated whether BK β1 and β4 subunits influence voluntary ethanol consumption using knockout mice. In a first experiment, mice were first subjected to continuous two-bottle choice (2BC and were then switched to intermittent 2BC, which progressively increased ethanol intake as previously described in wildtype mice. BK β1 or β4 subunit deficiency did not affect ethanol self-administration under either schedule of access. In a second experiment, mice were first trained to drink ethanol in a limited-access 2BC paradigm. BK β1 or β4 deletion did not affect baseline consumption. Weeks of 2BC were then alternated with weeks of chronic intermittent ethanol (CIE or air inhalation. As expected, a gradual escalation of ethanol drinking was observed in dependent wildtype mice, while intake remained stable in non-dependent wildtype mice. However, CIE exposure only produced a mild augmentation of ethanol consumption in BK β4 knockout mice. Conversely, ethanol drinking increased after fewer CIE cycles in BK β1 knockout mice than in wildtype mice. In conclusion, BK β1 or β4 did not influence voluntary ethanol drinking in non-dependent mice, regardless of the pattern of access to ethanol. However, deletion of BK β4 attenuated, while deletion of BK β1 accelerated, the escalation of ethanol drinking during withdrawal from CIE. Our data suggest that BK β1 and β4 subunits have an opposite influence on the negative reinforcing properties of ethanol withdrawal. Modulating the expression, distribution or interactions of BK channel auxiliary subunits may therefore represent a novel avenue for the

  15. Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits.

    Science.gov (United States)

    Li, Qin; Fan, Fei; Kwak, Ha Rim; Yan, Jiusheng

    2015-06-01

    Large conductance Ca(2+)- and voltage-activated potassium (BK) channels are comprised of pore-forming α subunits and various regulatory auxiliary subunits. The BK channel auxiliary γ (BKγ) subunits are a newly identified class of proteins containing an extracellular leucine-rich repeat domain (LRRD), a single transmembrane (TM) segment, and a short cytoplasmic C-terminal tail (C-tail). Although each of the four BKγ proteins shifts the voltage dependence of BK channel activation in a hyperpolarizing direction, they show markedly different efficacies, mediating shifts over a range of 15-145 mV. Analyses of chimeric BKγ subunits created by swapping individual structural elements, and of BKγ deletion and substitution mutants, revealed that differential modulation of BK gating by the four BKγ subunits depends on a small region consisting of the TM segment and the adjacent intracellular cluster of positively charged amino acids. The γ1 and γ2 TM segments contributed approximately -100 mV, and the γ1 and γ3 C-tails contributed approximately -40 mV, to shifting the voltage dependence of BK channel activation, whereas the γ3 and γ4 TM segments and the γ2 and γ4 C-tails contributed much less. The large extracellular LRRDs were mainly functionally interchangeable, although the γ1 LRRD was slightly less effective at enhancing (or slightly more effective at attenuating) the shift in BK channel voltage-dependent gating toward hyperpolarizing potentials than those of the other BKγ subunits. Analysis of mutated BKγ subunits revealed that juxta-membrane clusters of positively charged amino acids determine the functions of the γ1 and γ3 C-tails. Therefore, the modulatory functions of BKγ subunits are coarse- and fine-tuned, respectively, through variations in their TM segments and in the adjacent intracellular positively charged regions. Our results suggest that BK channel modulation by auxiliary γ subunits depends on intra- and/or juxta-membrane mechanisms

  16. BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells.

    Science.gov (United States)

    Edalat, Lena; Stegen, Benjamin; Klumpp, Lukas; Haehl, Erik; Schilbach, Karin; Lukowski, Robert; Kühnle, Matthias; Bernhardt, Günther; Buschauer, Armin; Zips, Daniel; Ruth, Peter; Huber, Stephan M

    2016-03-22

    Infiltration of the brain by glioblastoma cells reportedly requires Ca2+ signals and BK K+ channels that program and drive glioblastoma cell migration, respectively. Ionizing radiation (IR) has been shown to induce expression of the chemokine SDF-1, to alter the Ca2+ signaling, and to stimulate cell migration of glioblastoma cells. Here, we quantified fractionated IR-induced migration/brain infiltration of human glioblastoma cells in vitro and in an orthotopic mouse model and analyzed the role of SDF-1/CXCR4 signaling and BK channels. To this end, the radiation-induced migratory phenotypes of human T98G and far-red fluorescent U-87MG-Katushka glioblastoma cells were characterized by mRNA and protein expression, fura-2 Ca2+ imaging, BK patch-clamp recording and transfilter migration assay. In addition, U-87MG-Katushka cells were grown to solid glioblastomas in the right hemispheres of immunocompromised mice, fractionated irradiated (6 MV photons) with 5 × 0 or 5 × 2 Gy, and SDF-1, CXCR4, and BK protein expression by the tumor as well as glioblastoma brain infiltration was analyzed in dependence on BK channel targeting by systemic paxilline application concomitant to IR. As a result, IR stimulated SDF-1 signaling and induced migration of glioblastoma cells in vitro and in vivo. Importantly, paxilline blocked IR-induced migration in vivo. Collectively, our data demonstrate that fractionated IR of glioblastoma stimulates and BK K+ channel targeting mitigates migration and brain infiltration of glioblastoma cells in vivo. This suggests that BK channel targeting might represent a novel approach to overcome radiation-induced spreading of malignant brain tumors during radiotherapy. PMID:26893360

  17. Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits

    Science.gov (United States)

    Torres, Yolima P.; Granados, Sara T.; Latorre, Ramón

    2014-01-01

    Coded by a single gene (Slo1, KCM) and activated by depolarizing potentials and by a rise in intracellular Ca2+ concentration, the large conductance voltage- and Ca2+-activated K+ channel (BK) is unique among the superfamily of K+ channels. BK channels are tetramers characterized by a pore-forming α subunit containing seven transmembrane segments (instead of the six found in voltage-dependent K+ channels) and a large C terminus composed of two regulators of K+ conductance domains (RCK domains), where the Ca2+-binding sites reside. BK channels can be associated with accessory β subunits and, although different BK modulatory mechanisms have been described, greater interest has recently been placed on the role that the β subunits may play in the modulation of BK channel gating due to its physiological importance. Four β subunits have currently been identified (i.e., β1, β2, β3, and β4) and despite the fact that they all share the same topology, it has been shown that every β subunit has a specific tissue distribution and that they modify channel kinetics as well as their pharmacological properties and the apparent Ca2+ sensitivity of the α subunit in different ways. Additionally, different studies have shown that natural, endogenous, and synthetic compounds can modulate BK channels through β subunits. Considering the importance of these channels in different pathological conditions, such as hypertension and neurological disorders, this review focuses on the mechanisms by which these compounds modulate the biophysical properties of BK channels through the regulation of β subunits, as well as their potential therapeutic uses for diseases such as those mentioned above. PMID:25346693

  18. Tuning the mechanosensitivity of a BK channel by changing the linker length

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Some large-conductance Ca2+ and voltage-activated K+ (BK) channels are activated by membrane stretch. However, the mechanism of mechano-gating of the BK channels is still not well understood. Previous studies have led to the proposal that the tinker-gating ring complex functions as a passive spring, transducing the force generated by intraceilular Ca2+ to the gate to open the channel. This raises the question as to whether membrane stretch is also transmitted to the gate of mechanosensitive (MS) BK channels via the tinker-gating complex. To study this, we changed the linker length in the stretch-activated BK channel (SAKCaC), and examined the effect of membrane stretch on the gating of the resultant mutant channels. Shortening the tinker increased, whereas extending the tinker reduced, the channel mechanosensitivity both in the presence and in the absence of intracellular Ca2+. However, the voltage and Ca2+ sensitivities were not significantly altered by membrane stretch. Furthermore, the SAKCaC became less sensitive to membrane stretch at relatively high intracellular Ca2+ concentrations or membrane depolarization. These observations suggest that once the channel is in the open-state conformation, tension on the spring is partially released and membrane stretch is less effective. Our results are consistent with the idea that membrane stretch is transferred to the gate via the tinker-gating ring complex of the MS BK channels.

  19. Cuatro años de experiencia en el uso de tomografía computada multidetector en el trasplante de páncreas: aprendiendo junto a los cirujanos Four years of experience in the use of multidetector computer tomography in pancreas transplantation: a lesson learned together with surgeons

    Directory of Open Access Journals (Sweden)

    Hugo José Paladini

    2013-03-01

    Full Text Available Objetivo. Conocer la anatomía normal posquirúrgica del paciente con trasplante de páncreas en tomografía computada multidetector (TCMD y describir las complicaciones más frecuentes. Revisión de tema. El trasplante pancreático ha aumentado en los últimos años como estrategia terapéutica en pacientes diabéticos, siendo en la actualidad el único tratamiento eventualmente curativo. Según cifras del Instituto Nacional Central Único Coordinador de Ablación e Implante (INCUCAI, en el 2001 se realizaron 9 trasplantes renopancreáticos/pancreáticos, mientras que en el 2011 se practicaron 74. Esto nos obliga como radiólogos a conocer la anatomía normal posquirúrgica y a aprender a identificar las complicaciones más frecuentes. Los métodos imagenológicos utilizados son la ecografía/Doppler, la tomografía computada multidetector (TCMD, la angiografía convencional y la resonancia magnética (RM. En pacientes con buena función renal y ecografía no concluyente, para categorizar las complicaciones, la evaluación por tomografía computada multidetector es el paso siguiente. En nuestro hospital se realizaron 25 trasplantes pancreáticos en el período 2008-2012. Durante el posoperatorio, en 19 de ellos se sospecharon, por clínica o ecografía, complicaciones (a 15 de los cuales se les realizó tomografía computada. Conociendo la técnica quirúrgica, describimos la anatomía normal y desarrollamos las complicaciones posquirúrgicas más frecuentes: vasculares (trombosis, fístula arteriovenosa, pseudoaneurisma y no vasculares (pancreatitis, fístulas pancreáticas, colecciones, neumoperitoneo, íleo. Conclusión. La tomografía computada multidetector es un método de gran utilidad al momento de evaluar pacientes con trasplante pancreático. Un conocimiento cabal de la particular anatomía posquirúrgica y sus posibles complicaciones es crucial para el radiólogo, con el fin de orientar el seguimiento y tratamiento de estos pacientes

  20. Enfoques del trasplante pancreático y de Islotes de Lanngerhans en el tratamiento de la Diabetes

    Directory of Open Access Journals (Sweden)

    Rafael De Acha Torrez

    2011-06-01

    Full Text Available La diabetes es una enfermedad con gran repercusión a nivel mundial, los objetivos de una terapia prolongada, en pacientes con cierta limitación en la terapia exógena convencional son mejorar la calidad de vida con niveles normoglicemicossustentables. Los trasplantes de órgano o de islotes son alternativas promisorias para este fin. Por lo que el enfoque de las técnicas, historia y perspectivas a futuro es de gran interés dentro de múltiples campos como la cirugía, la endocrinología, la medicina interna, finalmente y más importante la vida del paciente.

  1. Cuidados de enfermería en el paciente sometido a trasplante de médula.

    OpenAIRE

    Díez Esteban, M.E.; De Juan García, N.

    2006-01-01

    El objetivo de este artículo es describir qué es el trasplante de médula, cómo se realiza, qué complicaciones médicas pueden surgir a lo largo de todo el proceso y cuál va ser nuestra actuación enfermera. La definición oficial de diagnóstico de enfermería de la NANDA vincula de forma específica el diagnóstico con las intervenciones de enfermería. Pero, ¿qué sucede con otras situaciones clínicas (no cubiertas por los diagnósticos de enfermería) que necesitan intervencio...

  2. Fusion and quasifission dynamics in the reactions 48Ca+249Bk and 50Ti+249Bk using a time-dependent Hartree-Fock approach

    Science.gov (United States)

    Umar, A. S.; Oberacker, V. E.; Simenel, C.

    2016-08-01

    Background: Synthesis of superheavy elements (SHEs) with fusion-evaporation reactions is strongly hindered by the quasifission (QF) mechanism which prevents the formation of an equilibrated compound nucleus and which depends on the structure of the reactants. New SHEs have been recently produced with doubly-magic 48Ca beams. However, SHE synthesis experiments with single-magic 50Ti beams have so far been unsuccessful. Purpose: In connection with experimental searches for Z =117 ,119 superheavy elements, we perform a theoretical study of fusion and quasifission mechanisms in 48Ca,50Ti+249Bk reactions in order to investigate possible differences in reaction mechanisms induced by these two projectiles. Methods: The collision dynamics and the outcome of the reactions are studied using unrestricted time-dependent Hartree-Fock (TDHF) calculations as well as the density-constrained TDHF method to extract the nucleus-nucleus potentials and the excitation energy in each fragment. Results: Nucleus-nucleus potentials, nuclear contact times, masses and charges of the fragments, as well as their kinetic and excitation energies strongly depend on the orientation of the prolate 249Bk nucleus. Long contact times associated with fusion are observed in collisions of both projectiles with the side of the 249Bk nucleus, but not on collisions with its tip. The energy and impact parameter dependencies of the fragment properties, as well as their mass-angle and mass-total kinetic energy correlations are investigated. Conclusions: Entrance channel reaction dynamics are similar with both 48Ca and 50Ti projectiles. Both are expected to lead to the formation of a compound nucleus by fusion if they have enough energy to get in contact with the side of the 249Bk target.

  3. Trasplante de tráquea: papel del anestesiólogo Role of the anesthesiologist in tracheal transplantation

    Directory of Open Access Journals (Sweden)

    Héctor Darío Arroyave Páramo

    2008-01-01

    Full Text Available

    El trasplante de tráquea es un procedimiento novedoso no solo en Colombia sino también en el ámbito mundial. Los retos que plantea al grupo tratante son de tal complejidad que deben ser asumidos en forma interdisciplinaria para obtener los mejores resultados posibles. Por ello el anestesiólogo debe integrarse muy activamente en todas las fases de atención del paciente que va a ser trasplantado: planeación, manejo en el quirófano, cuidado intensivo y hospitalización; de este modo puede enfocar integral y oportunamente el tratamiento haciendo uso de sus conocimientos especializados acerca de la vía aérea y del comportamiento hemodinámico. Se presenta en este artículo una visión panorámica del papel del anestesiólogo con base en la experiencia de 11 trasplantes traqueales en Medellín, Colombia.

     

    Worldwide, tracheal transplantation is a novel procedure; it poses very complex challenges that must be assumed by an interdisciplinary group in order to obtain optimal results. Because of their specialized knowledge, anesthesiologists must be actively involved in every step of the management of patients undergoing such transplantation, namely: planning, intraoperative and intensive care and hospitalization after the latter. A general overview of anesthesiologists’ role is presented based on the experience of 11 tracheal transplantations in Medellín, Colombia

  4. Indicaciones, técnicas y resultados del trasplante de intestino delgado Indications, techniques and outcomes of small bowel transplant

    Directory of Open Access Journals (Sweden)

    M. López Santamaría

    2007-05-01

    Full Text Available Los resultados más recientes del trasplante intestinal (TI, con una supervivencia inmediata al procedimiento superior al 80% de los casos, y una gran proporción de supervivientes que consiguen autonomía digestiva completa y desempeñan actividades acordes con su edad, permiten considerar el TI como el tratamiento de elección en enfermos con fallo intestinal irreversible en los que es previsible una mala evolución con nutrición parenteral. El daño hepático asociado a la administración de nutrición parenteral es la indicación más frecuente de TI, especialmente en los niños, más susceptibles que los adultos a desarrollar esta complicación. Otras indicaciones aceptadas de TI son el fallo intestinal irreversible asociado a pérdida significativa de accesos venosos profundos, infecciones graves con riesgo vital asociadas al uso de catéteres centrales, y casos de fracaso intestinal que conducen habitualmente a muerte precoz, como cuadros de intestino ultracorto, diarreas intratables, y fallo intestinal asociado a elevada morbilidad y mala calidad de vida. El TI se practica en clínica humana bajo tres modalidades técnicas: trasplante de intestino aislado, trasplante combinado de hígado intestino y trasplante multivisceral. Refinamientos de las técnicas originales, que incluyen reducciones de los injertos hepáticos y/o intestinales, la opción con injerto de donante vivo, etc. permiten actualmente cubrir las diferentes necesidades, a la vez que incrementar la probabilidad de acceso al trasplante, objetivo especialmente necesario en niños muy pequeños o de muy bajo peso candidatos a trasplante hepatointestinal. Uno de los aspectos más interesantes de los programas de TI es haber permitido la evolución hacia Unidades de Rehabilitación Intestinal, que integran en un equipo multidisciplinar las tres modalidades de tratamiento: soporte nutricional, farmacoterapia y cirugía. Estas Unidades optimizan los resultados, minimizan los

  5. Molecular investigations of BK(Ca) channels and the modulatory beta-subunits in porcine basilar and middle cerebral arteries

    DEFF Research Database (Denmark)

    Johansson, Helle Wulf; Hay-Schmidt, Anders; Poulsen, Asser Nyander;

    2009-01-01

    Large conductance calcium-activated potassium (BK(Ca)) channels are fundamental in the regulation of cerebral vascular basal tone. We investigated the expression of the mRNA transcripts for the BK(Ca) channel and its modulatory beta-subunits (beta1-beta4) in porcine basilar and middle cerebral...

  6. Implementación y resultados de un nuevo programa de ECMO para trasplante de pulmón y distrés respiratorio agudo

    Directory of Open Access Journals (Sweden)

    Eduardo San Roman

    2015-06-01

    Full Text Available RESUMEN Objetivo: El desarrollo de la membrana de oxigenación extracorpórea en América Latina representa un desafío para la especialidad. El objetivo de este artículo fue describir los resultados de un nuevo programa de membrana de oxigenación extracorpórea en una unidad de cuidados intensivos. Métodos: Estudio de cohorte retrospectivo. Incluye 22 pacientes que requirieron membrana de oxigenación extracorpórea desde Enero de 2011 hasta Junio de 2014. Se evaluaron características basales, indicaciones, duración de la corrida, días de ventilación mecánica, días de unidad de cuidados intensivos, complicaciones y mortalidad hospitalaria. Resultados: Quince pacientes requirieron membrana de oxigenación extracorpórea post-trasplante pulmonar y 7 pacientes por distrés respiratorio agudo. Todos los pacientes trasplantados fueron destetados de membrana de oxigenación extracorpórea, con una duración mediana de 3 días (Rango intercuantil - IQR: 2 - 5, de ventilación mecánica 15,5 días (IQR: 3 - 35, de estadía unidad de cuidados intensivos 31,5 días (IQR: 19 - 53 y de estadía hospitalaria 60 días (IQR: 36 - 89, con una mortalidad de 20%. Los pacientes con distrés respiratorio agudo tuvieron una mediana de duración de membrana de oxigenación extracorpórea de 9 días (IQR: 3 - 14, mediana de ventilación mecánica 25 días (IQR: 13 - 37, de estadía en terapia 31 días (IQR: 11 - 38, y hospitalaria 32 días (IQR: 11 - 41, y 57% de mortalidad. Las principales complicaciones fueron infecciones (80%, insuficiencia renal aguda (43%, sangrados en sitio quirúrgico y de inserción de cánulas (22%, plaquetopenia (60% y coagulopatía (30%. Conclusión: A pesar de encontrarnos transitando una curva de aprendizaje, consideramos la experiencia satisfactoria, con resultados y complicaciones comparables a las reportadas en la literatura.

  7. CALIDAD DE VIDA Y ESTRATEGIAS DE AFRONTAMIENTO EN PACIENTES CON INSUFICIENCIA RENAL CRÓNICA SOMETIDOS A HEMODIÁLISIS, DIÁLISIS PERITONEAL Y TRASPLANTE RENAL

    Directory of Open Access Journals (Sweden)

    Cesar Armando Rey Anacona

    2008-07-01

    Full Text Available Se comparó la calidad de vida y las estrategias de afrontamiento en 120 pacientes con Insuficiencia Renal Crónica sometidos a hemodiálisis, diálisis peritoneal o trasplante renal, teniendo en cuenta la edad, sexo, escolaridad, estado civil y ocupación. Los instrumentos utilizados fueron una ficha sociodemográfica, la prueba de calidad de vida WHOQOL-100 (Organización Mundial de la Salud, 1998 y el Cuestionario de Estrategias de Afrontamiento (Lazarus & Folkman, 1985. Se encontró que los pacientes en tratamiento de trasplante reportaban mayor calidad de vida y mejores estrategias de afrontamiento en comparación con los otros tratamientos, siendo mayores las puntuaciones en personas con edad de transición entre adultez media y tardía, mujeres, con estudios universitarios, casados y empleados. Se discuten las implicaciones de estos hallazgos.

  8. Airway Hydration, Apical K(+) Secretion, and the Large-Conductance, Ca(2+)-activated and Voltage-dependent Potassium (BK) Channel.

    Science.gov (United States)

    Kis, Adrian; Krick, Stefanie; Baumlin, Nathalie; Salathe, Matthias

    2016-04-01

    Large-conductance, calcium-activated, and voltage-gated K(+) (BK) channels are expressed in many tissues of the human body, where they play important roles in signaling not only in excitable but also in nonexcitable cells. Because BK channel properties are rendered in part by their association with four β and four γ subunits, their channel function can differ drastically, depending on in which cellular system they are expressed. Recent studies verify the importance of apically expressed BK channels for airway surface liquid homeostasis and therefore of their significant role in mucociliary clearance. Here, we review evidence that inflammatory cytokines, which contribute to airway diseases, can lead to reduced BK activity via a functional down-regulation of the γ regulatory subunit LRRC26. Therefore, manipulation of LRRC26 and pharmacological opening of BK channels represent two novel concepts of targeting epithelial dysfunction in inflammatory airway diseases. PMID:27115952

  9. Evaluación nutricional de pacientes candidatos a lista de espera de trasplante renopancreático Nutritional assessment of patients candidates for waiting list simultaneous kidney pancreas transplantation

    Directory of Open Access Journals (Sweden)

    M.ª L. Iglesias

    2010-06-01

    Full Text Available Introducción: El trasplante renopancreático es en la actualidad el tratamiento elegido para los pacientes diabéticos tipo 1 con ERD avanzada. Estudios científicos sobre los beneficios de esta terapéutica avalan la aceptación de la misma como lo más adecuado para los pacientes. La independencia de diálisis y de tratamiento insulínico luego del trasplante representa un importante incremento en la calidad de vida de esos pacientes. En los últimos años, la importancia de la evaluación nutricional en pacientes con enfermedades crónicas ha aumentado. Existe cada vez más evidencia científica que la malnutrición esta asociada a un riesgo mayor de morbilidad y mortalidad post intervención quirúrgica. Teniendo en cuenta la terapéutica elegida para estos pacientes y la importancia del estado nutricional como factor predictor independiente de riesgo de complicaciones post trasplante es objetivo de nuestro trabajo describir el estado nutricional de los pacientes candidatos a trasplante renopancreatico a través de parámetros objetivos y subjetivos de valoración nutricional. Materiales y métodos: Se incluyeron 45 pacientes Diabéticos tipo 1 con ERD internados en el Hospital Italiano de Buenos Aires para evaluación pre trasplante renopancreático durante el período Junio 2007-Junio 2008. Se recolectaron los datos mediante una ficha de elaboración propia. Como parámetro antropométrico se calculó el Índice de Masa corporal (IMC mediante la fórmula de Quetelet (Peso post diálisis (kg/talla 2 (mts y se clasificó según los rangos propuestos por el comité de Expertos de la OMS. Como parámetro subjetivo se realizo la Valoración Global Subjetiva (VGS que clasificó a los pacientes en Bien nutrido (A, desnutrido leve (B, desnutrido moderado (C y desnutrido severo (D. Como parámetros bioquímicos se registró el dato de albúmina sérica (g/dl al ingreso hospitalario y este dato se obtuvo de la historia clínica del paciente

  10. The Disappearance of the Red Supergiant Progenitor of Supernova 2008bk

    OpenAIRE

    Mattila, Seppo; Smartt, Stephen; Maund, Justyn; Benetti, Stefano; Ergon, Mattias

    2010-01-01

    Massive stars end their lives in spectacular supernova explosions. Identifying the progenitor star is a test of stellar evolution and explosion models. Here we show that the progenitor star of the supernova SN 2008bk has now disappeared, which provides conclusive evidence that this was the death of a red supergiant star.

  11. New properties of BK-spaces defined by using regular matrix of Fibonacci numbers

    Science.gov (United States)

    Ercan, Sinan; Bektaş, ćiǧdem A.

    2016-06-01

    In the present paper, we studied the new properties of BK-spaces which were defined using regular matrix of Fibonacci numbers in [1]. We computed alpha-, beta-, gamma- duals of these spaces and obtained Schauder basis. We also derived some topological properties of these spaces.

  12. Evaluation of polyomavirus BK reactivation in lupus patients who underwent kidney transplantation

    Directory of Open Access Journals (Sweden)

    Cristina Costa

    2012-06-01

    Full Text Available Background. A pathogenic role for polyomavirus BK in systemic lupus erythematosus (SLE has been proposed, however no study evaluated the occurrence of BK replication in renal transplant recipients according to the underlying disease leading to transplantation and its potential impact. Methods. The occurrence of BK reactivation was serially evaluated in 468 renal transplant recipients, including 11 patients with SLE as underlying disease (overall, 2370 serum and 2370 urine specimens; 65 from SLE patients. Results. Considering the overall occurrence of viral reactivation (viremia and/or viruria, 26/65 (40% specimens were positive in four SLE patients (36.3% versus 331/2143 (15.4% in 130/227 (57.3% non-SLE patients. A patient transplanted for class III lupus nephritis evidenced sustained BK viremia and viruria (with viremia values potentially indicative of polyomavirus-associated nephropathy in the absence of clinical features of renal dysfunction or recurrence of lupus nephritis. Conclusions. Further studies on larger populations and for a longer follow-up should be required to evaluate the impact of BKV reactivation in renal transplant patients with SLE as underlying disease, as well as the potential therapeutic implications.

  13. Differential expression of BK channel isoforms and beta-subunits in rat neuro-vascular tissues

    DEFF Research Database (Denmark)

    Poulsen, Asser Nyander; Johansson, Helle Wulf; Hay-Schmidt, Anders;

    2009-01-01

    We investigated the expression of splice variants and beta-subunits of the BK channel (big conductance Ca(2+)-activated K(+) channel, Slo1, MaxiK, K(Ca)1.1) in rat cerebral blood vessels, meninges, trigeminal ganglion among other tissues. An alpha-subunit splice variant X1(+24) was found expressed...

  14. Molecular studies of BKCa channels in intracranial arteries

    DEFF Research Database (Denmark)

    Wulf, Helle; Hay-Schmidt, Anders; Poulsen, Asser Nyander;

    2008-01-01

      Large conductance calcium-activated potassium channels (BK(ca)) are crucial for the regulation of cerebral vascular basal tone and might be involved in cerebral vasodilation relevant to migraine and stroke. We studied the differential gene expression of mRNA transcript levels and protein...

  15. Activities of Different Classes of Acyclic Nucleoside Phosphonates against BK Virus in Primary Human Renal Cells

    Czech Academy of Sciences Publication Activity Database

    Topalis, D.; Lebeau, I.; Krečmerová, Marcela; Andrei, G.; Snoeck, R.

    2011-01-01

    Roč. 55, č. 5 (2011), s. 1961-1967. ISSN 0066-4804 Institutional research plan: CEZ:AV0Z40550506 Keywords : polyomavirus * BK virus * nephropathy * acyclic nucleoside phosphonates * HPMP-5-azaC Subject RIV: CC - Organic Chemistry Impact factor: 4.841, year: 2011

  16. Intermediate-dose cidofovir without probenecid in the treatment of BK virus allograft nephropathy.

    Science.gov (United States)

    Araya, Carlos E; Lew, Judy F; Fennell, Robert S; Neiberger, Richard E; Dharnidharka, Vikas R

    2006-02-01

    BK virus allograft nephropathy (BKVAN) is a rising complication in kidney transplant recipients. Reducing immunosuppression has been the initial form of therapy in most cases, but is not always associated with improvement in graft function. Anti-viral therapy with low-dose cidofovir (0.25-0.42 mg/kg/dose) has been used successfully in some patients, but dose-related nephrotoxicity has limited its use. We present our experience with 3 kidney transplant recipients diagnosed with BKVAN who received intermediate-dose cidofovir (0.75-1.0 mg/kg/dose) without probenecid, and without concomitant nephrotoxicity. Three female patients, ages 8, 19 and 20 yr, presented with elevated serum creatinine (SCr) values, BK virus stain positive on renal biopsy and high plasma BK viral loads. As a result of viral loads being >2 million copies/ml in two patients and a lack of response to reduction in immunosuppression in the third, we initiated therapy with low-dose cidofovir. Because of persistent positive BK stain and positive plasma viral load, we then administered intermediate-dose cidofovir, without probenecid, for several subsequent doses (seven to 15 infusions till date). All patients tolerated the intermediate-dose cidofovir with no significant rise in SCr during the course of the infusions. The most recent SCr values in all three patients were improved from those at the initial diagnosis of BKVAN. All three patients showed a marked drop in BK viral loads when on intermediate-dose cidofovir, with complete clearing of viremia in two patients. In our experience, intermediate-dose cidofovir without probenecid, used judiciously, is not associated with additional nephrotoxicity and may provide an additional alternative for treatment. PMID:16499584

  17. Surveillance of polyomavirus BK in relation to immunosuppressive therapy in kidney transplantation

    Directory of Open Access Journals (Sweden)

    Cristina Costa

    2012-03-01

    Full Text Available Introduction. Reactivation of polyomavirus BK in kidney transplant recipients has been associated to the development of nephropathy (polyomavirus-associated nephropathy, PVAN, possibly leading to the loss of the transplanted organ. Immunosuppression is the condicio sine qua non for the onset of PVAN; however, a lower incidence of BK viremia has been reported with low-level tacrolimus based immunosuppressive protocols in comparison to cyclosporine A.Aim of this study was to compare the two immunosuppressive protocols. Methods. Virological monitoring of BK was performed in 468 consecutive renal transplant patients over a period of 3 years (2370 urine e 2370 serum specimens: in particular, 1780 specimens from 362 patients treated with tacrolimus and 590 from 106 treated with cyclosporine A. Results. BK viremia was evidenced in 124 (7.0% and 12 (2.0% specimens from 40 (11.0% and 11 (10.4% patients treated with tacrolimus and cyclosporine A, respectively; similarly, BK viruria in 289 (16.2% and 58 (9.8% specimens from 67 (18.5% and 27 (25.5% patients, being the difference of incidence highly significant (p <0.0001 for both viremia and viruria at comparison between specimens and not significant for patients. No case of PVAN was diagnosed at histophatology evaluation. Conclusions. The incidence of viremia and viruria was similar to that previously reported. Our results evidenced that with low-level tacrolimus-based protocols the overall incidence of reactivation in renal transplant patients is not significantly different and there is no increased risk of PVAN, nevertheless the higher incidence of episodes of reactivation.

  18. Similar enhancement of BK(Ca) channel function despite different aerobic exercise frequency in aging cerebrovascular myocytes.

    Science.gov (United States)

    Li, N; Liu, B; Xiang, S; Shi, L

    2016-07-18

    Aerobic exercise showed beneficial influence on cardiovascular systems in aging, and mechanisms underlying vascular adaption remain unclear. Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels play critical roles in regulating cellular excitability and vascular tone. This study determined the effects of aerobic exercise on aging-associated functional changes in BK(Ca) channels in cerebrovascular myocytes, Male Wistar rats aged 20-22 months were randomly assigned to sedentary (O-SED), low training frequency (O-EXL), and high training frequency group (O-EXH). Young rats were used as control. Compared to young rats, whole-cell BK(Ca) current was decreased, and amplitude of spontaneous transient outward currents were reduced. The open probability and Ca(2+)/voltage sensitivity of single BK(Ca) channel were declined in O-SED, accompanied with a reduction of tamoxifen-induced BK(Ca) activation; the mean open time of BK(Ca) channels was shortened whereas close time was prolonged. Aerobic exercise training markedly alleviated the aging-associated decline independent of training frequency. Exercise three times rather than five times weekly may be a time and cost-saving training volume required to offer beneficial effects to offset the functional declines of BK(Ca) during aging. PMID:27070745

  19. Urological management (medical and surgical of BK-virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Nikhil Vasdev

    2013-10-01

    Full Text Available Aim: Haemorrhagic cystitis (HC is uncommon and in its severe form potentially life threatening complication of Haematopoietic stem cell transplantation (HSCT in children. We present our single centre experience in the urological management of this clinically challenging condition. Patients and Methods: Fourteen patients were diagnosed with BK-Virus HC in our centre. The mean age at diagnosis was 8.8 years (range, 3.2-18.4 years. The mean number of days post-BMT until onset of HC was 20.8 (range, 1 – 51. While all patients tested urine positive for BKV at the clinical onset of HC, only four patients had viral quantification, with viral loads ranging from 97,000 to >1 billion/ml. 8 patients had clinical HC. Ten patients experienced acute GVHD (grade I: 6 patients, grade II: 3 patients, grade 4: 1 patient.Results: Four patients received medical management for their HC. Treatments included hyperhydration, MESNA, blood and platelet transfusion, premarin and oxybutynin (Table 6.  Two patients received both medical and surgical management which included cystoscopy with clot evacuation, bladder irrigation and supra-pubic catheter insertion. One patient received exclusive surgical management. Seven patients were treated conservatively. Conclusion: There is limited available evidence for other potential therapeutic strategies highlighting the need for more research into the pathophysiology of HSCT-associated HC. Commonly used interventions with possible clinical benefit (e.g. cidofovir, ciprofloxacin still require to be evaluated in multi-centre, high-quality studies. Potential future preventative and therapeutic options, such as modulation of conditioning, immunosuppression and engraftment, new antiviral and anti-inflammatory and less nephrotoxic agents need to be assessed.---------------------------Cite this article as:Vasdev N, Davidson A, Harkensee C, Slatter M, Gennery A, Willetts I, Thorpe A.Urological management (medical and surgical of BK

  20. Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior

    Directory of Open Access Journals (Sweden)

    Alex M. Dopico

    2014-12-01

    Full Text Available In most tissues, the function of calcium- and voltage-gated potassium (BK channels is modified in response to ethanol concentrations reached in human blood during alcohol intoxication. In general, modification of BK current from ethanol-naïve preparations in response to brief ethanol exposure results from changes in channel open probability without modification of unitary conductance or change in BK protein levels in the membrane. Protracted and/or repeated ethanol exposure, however, may evoke changes in BK expression. The final ethanol effect on BK open probability leading to either BK current potentiation or BK current reduction is determined by an orchestration of molecular factors, including levels of activating ligand (cytosolic calcium, BK subunit composition and posttranslational modifications, and the channel’s lipid microenvironment. These factors seem to allosterically regulate a direct interaction between ethanol and a recognition pocket of discrete dimensions recently mapped to the channel-forming (slo1 subunit. Type of ethanol exposure also plays a role in the final BK response to the drug: in several central nervous system regions (e.g., striatum, primary sensory neurons, and supraoptic nucleus, acute exposure to ethanol reduces neuronal excitability by enhancing BK activity. In contrast, protracted or repetitive ethanol administration may alter BK subunit composition and membrane expression, rendering the BK complex insensitive to further ethanol exposure. In neurohypophysial axon terminals, ethanol potentiation of BK channel activity leads to a reduction in neuropeptide release. In vascular smooth muscle, however, ethanol inhibition of BK current leads to cell contraction and vascular constriction.

  1. An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients

    OpenAIRE

    Emilie Pambrun; Catherine Mengelle; Geneviève Fillola; Patrick Laharrague; Laure Esposito; Isabelle Cardeau-Desangles; Arnaud Del Bello; Jacques Izopet; Lionel Rostaing; Nassim Kamar

    2014-01-01

    The human polyomavirus BK (BKV) is associated with severe complications, such as ureteric stenosis and polyomavirus-associated nephropathy (PVAN), which often occur in kidney-transplant patients. However, it is unknown if BKV can replicate within bone marrow. The aim of this study was to search for BKV replication within the bone marrow of kidney-transplant patients presenting with a hematological disorder. Seventy-two kidney-transplant patients underwent bone-marrow aspiration for cytopenia....

  2. Inhibition of intestinal motility by the putative BK(Ca) channel opener LDD175.

    Science.gov (United States)

    Dela Peña, Ike Campomayor; Yoon, Seo Young; Kim, Sung Mok; Lee, Geum Seon; Park, Chul-Seung; Kim, Yong Chul; Cheong, Jae Hoon

    2009-03-01

    LDD175 (4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid) is a benzofuroindole compound characterized previously as a potent opener of the large conductance calcium activated (BK(Ca)) channels. Activators of the BK(Ca) channels are potential therapies for smooth muscle hyperactivity disorders. The present study investigates the influence of LDD175 on the mechanical activity of the ileum smooth muscle. LDD175 inhibited spontaneous contractions of the ileum in a concentration-dependent manner (pEC(50)=5.9 +/- 0.1) (E (max)=96 +/- 1.0% at 100 muM, n=3). It also remarkably inhibited contractions due to acetylcholine (ACh) (pEC(50)=5.3 +/- 0.1)(E (max)=97.7 +/- 2.3%, n=6) and electrical field stimulation (EFS) (pEC(50)=5.5 +/- 0.1) (E (max)=83.3 +/- 6.0%, n=6). In strips precontracted by 20 mM KCl, LDD175 significantly reduced the contractions yielding a pEC(50) of 6.1 +/- 0.1 and E (max) of 96.6 +/- 0.9%, (n=6). In 60 mM KCl, a concentration-dependent inhibition was observed with respective pEC(50) and E (max) values of 4.1 +/- 0.1 and 50.8 +/- 5.0% (n=3). BK(Ca) channel blockers iberiotoxin (IbTX) and tetraethylammonium chloride (TEA, 1 mM) attenuated the relaxative effect of LDD175 but not barium chloride (BaCl(2)), and glibenclamide (K(IR) and K(ATP) channel blockers, respectively). These data demonstrate the antispasmodic activity of LDD175 attributable to the potentiation of the BK(Ca) channels. PMID:19387586

  3. BK channels regulate spontaneous action potential rhythmicity in the suprachiasmatic nucleus.

    Directory of Open Access Journals (Sweden)

    Jack Kent

    Full Text Available BACKGROUND: Circadian ( approximately 24 hr rhythms are generated by the central pacemaker localized to the suprachiasmatic nucleus (SCN of the hypothalamus. Although the basis for intrinsic rhythmicity is generally understood to rely on transcription factors encoded by "clock genes", less is known about the daily regulation of SCN neuronal activity patterns that communicate a circadian time signal to downstream behaviors and physiological systems. Action potentials in the SCN are necessary for the circadian timing of behavior, and individual SCN neurons modulate their spontaneous firing rate (SFR over the daily cycle, suggesting that the circadian patterning of neuronal activity is necessary for normal behavioral rhythm expression. The BK K(+ channel plays an important role in suppressing spontaneous firing at night in SCN neurons. Deletion of the Kcnma1 gene, encoding the BK channel, causes degradation of circadian behavioral and physiological rhythms. METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis that loss of robust behavioral rhythmicity in Kcnma1(-/- mice is due to the disruption of SFR rhythms in the SCN, we used multi-electrode arrays to record extracellular action potentials from acute wild-type (WT and Kcnma1(-/- slices. Patterns of activity in the SCN were tracked simultaneously for up to 3 days, and the phase, period, and synchronization of SFR rhythms were examined. Loss of BK channels increased arrhythmicity but also altered the amplitude and period of rhythmic activity. Unexpectedly, Kcnma1(-/- SCNs showed increased variability in the timing of the daily SFR peak. CONCLUSIONS/SIGNIFICANCE: These results suggest that BK channels regulate multiple aspects of the circadian patterning of neuronal activity in the SCN. In addition, these data illustrate the characteristics of a disrupted SCN rhythm downstream of clock gene-mediated timekeeping and its relationship to behavioral rhythms.

  4. Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration

    Directory of Open Access Journals (Sweden)

    Bartley Jeremy W

    2009-09-01

    Full Text Available Abstract This study examined the effect of menthol, an agonist for transient receptor potential melastatin 8 (TRPM8 ion channels, to increase intracellular Ca2+ concentration, [Ca2+]i, in human glioblastoma cells (DBTRG cells, which resulted in activation of the large-conductance Ca2+-activated K+ membrane ion channels (BK channels. Voltage ramps applied over 300 ms from -100 to 100 mV resulted in membrane currents with marked inwardly- and outwardly-rectifying components. Paxilline (2 μM abolished the outwardly-rectifying current. Outwardly-rectifying on-cell patch currents were increased markedly by menthol (100 μM added to the bath. The estimated on-cell conductance of these channels was 253 pS. Kinetic analysis showed that added menthol increased channel open probability and mean open frequency after 5 min. In a similar time course menthol increased [Ca2+]i, and this increase was abolished either by added paxilline, tetraethylammonium ion or by Ca2+-free external solution. Finally, menthol stimulated the rate of DBTRG cell migration into scratch wounds made in confluent cells, and this also was inhibited by paxilline or by tetraethylammonium ion. We conclude that menthol, a TRPM8 agonist, increases DBTRG cell [Ca2+]i that in turn activates membrane BK ion channels. Inhibition of BK channels by paxilline reverses menthol-stimulated increase of [Ca2+]i and of cell migration. Thus, BK channels function to maintain elevations in [Ca2+]i needed to sustain increases in DBTRG cell migration.

  5. Viral DNA Replication-Dependent DNA Damage Response Activation during BK Polyomavirus Infection

    OpenAIRE

    Verhalen, Brandy; Justice, Joshua L.; Imperiale, Michael J; Jiang, Mengxi

    2015-01-01

    BK polyomavirus (BKPyV) reactivation is associated with severe human disease in kidney and bone marrow transplant patients. The interplay between viral and host factors that regulates the productive infection process remains poorly understood. We have previously reported that the cellular DNA damage response (DDR) is activated upon lytic BKPyV infection and that its activation is required for optimal viral replication in primary kidney epithelial cells. In this report, we set out to determine...

  6. BK/TD models for analyzing in vitro impedance data on cytotoxicity

    OpenAIRE

    Teng, Sophie; Barcellini-Couget, Sylvie; Beaudoin, Rémy; Desousa, Georges; Rahmani, Roger; Pery, Alexandre

    2015-01-01

    The ban of animal testing has enhanced the development of new in vitro technologies for cosmetics safety assessment. Impedance metrics is one such technology which enables monitoring of cell viability in real time. However, analyzing real time data requires moving from static to dynamic toxicity assessment. In the present study, we built mechanistic biokinetic/toxicodynamic (BK/TD) models to analyze the time course of cell viability in cytotoxicity assay using impedance. These models accou...

  7. Restriction of Human Polyomavirus BK Virus DNA Replication in Murine Cells and Extracts

    OpenAIRE

    Mahon, C.; Liang, B.; Tikhanovich, I.; et al

    2009-01-01

    BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with which to study activation of BKV replication in the human kidney and the accompanying PVAN. Here we report studies of the restriction of BKV replication in murine cells and extracts and the cause(s) of this restriction. Upon infection of murine cells, BKV expressed large T anti...

  8. BK virus encephalopathy and sclerosing vasculopathy in a patient with hypohidrotic ectodermal dysplasia and immunodeficiency

    OpenAIRE

    Darbinyan, Armine; Major, Eugene O.; Morgello, Susan; Holland, Steven; Ryschkewitsch, Caroline; Monaco, Maria Chiara; Naidich, Thomas P.; Bederson, Joshua; Malaczynska, Joanna; Ye, Fei; Gordon, Ronald; Cunningham-Rundles, Charlotte; Fowkes, Mary; Tsankova, Nadejda M.

    2016-01-01

    Human BK polyomavirus (BKV) is reactivated under conditions of immunosuppression leading most commonly to nephropathy or cystitis; its tropism for the brain is rare and poorly understood. We present a unique case of BKV-associated encephalopathy in a man with hypohidrotic ectodermal dysplasia and immunodeficiency (HED-ID) due to IKK-gamma (NEMO) mutation, who developed progressive neurological symptoms. Brain biopsy demonstrated polyomavirus infection of gray and white matter, with predominan...

  9. BK virus has tropism for human salivary gland cells in vitro: Implications for transmission

    International Nuclear Information System (INIS)

    Background: In this study, it was determined that BKV is shed in saliva and an in vitro model system was developed whereby BKV can productively infect both submandibular (HSG) and parotid (HSY) salivary gland cell lines. Results: BKV was detected in oral fluids using quantitative real-time PCR (QRTPCR). BKV infection was determined using quantitative RT-PCR, immunofluorescence and immunoblotting assays. The infectivity of BKV was inhibited by pre-incubation of the virus with gangliosides that saturated the major capsid protein, VP1, halting receptor mediated BKV entry into salivary gland cells. Examination of infected cultures by transmission electron microscopy revealed 45-50 nm BK virions clearly visible within the cells. Subsequent to infection, encapsidated BK virus was detected in the supernatant. Conclusion: We thus demonstrated that BKV was detected in oral fluids and that BK infection and replication occur in vitro in salivary gland cells. These data collectively suggest the potential for BKV oral route of transmission and oral pathogenesis.

  10. A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel

    Directory of Open Access Journals (Sweden)

    Andrew P. Wojtovich

    2013-03-01

    Full Text Available Opening of BK-type Ca2+ activated K+ channels protects the heart against ischemia-reperfusion (IR injury. However, the location of BK channels responsible for cardioprotection is debated. Herein we confirmed that openers of the SLO1 BK channel, NS1619 and NS11021, were protective in a mouse perfused heart model of IR injury. As anticipated, deletion of the Slo1 gene blocked this protection. However, in an isolated cardiomyocyte model of IR injury, protection by NS1619 and NS11021 was insensitive to Slo1 deletion. These data suggest that protection in intact hearts occurs by a non-cardiomyocyte autonomous, SLO1-dependent, mechanism. In this regard, an in-situ assay of intrinsic cardiac neuronal function (tachycardic response to nicotine revealed that NS1619 preserved cardiac neurons following IR injury. Furthermore, blockade of synaptic transmission by hexamethonium suppressed cardioprotection by NS1619 in intact hearts. These results suggest that opening SLO1 protects the heart during IR injury, via a mechanism that involves intrinsic cardiac neurons. Cardiac neuronal ion channels may be useful therapeutic targets for eliciting cardioprotection.

  11. BK/TD models for analyzing in vitro impedance data on cytotoxicity.

    Science.gov (United States)

    Teng, S; Barcellini-Couget, S; Beaudouin, R; Brochot, C; Desousa, G; Rahmani, R; Pery, A R R

    2015-06-01

    The ban of animal testing has enhanced the development of new in vitro technologies for cosmetics safety assessment. Impedance metrics is one such technology which enables monitoring of cell viability in real time. However, analyzing real time data requires moving from static to dynamic toxicity assessment. In the present study, we built mechanistic biokinetic/toxicodynamic (BK/TD) models to analyze the time course of cell viability in cytotoxicity assay using impedance. These models account for the fate of the tested compounds during the assay. BK/TD models were applied to analyze HepaRG cell viability, after single (48 h) and repeated (4 weeks) exposures to three hepatotoxic compounds (coumarin, isoeugenol and benzophenone-2). The BK/TD models properly fit the data used for their calibration that was obtained for single or repeated exposure. Only for one out of the three compounds, the models calibrated with a single exposure were able to predict repeated exposure data. We therefore recommend the use of long-term exposure in vitro data in order to adequately account for chronic hepatotoxic effects. The models we propose here are capable of being coupled with human biokinetic models in order to relate dose exposure and human hepatotoxicity. PMID:25827406

  12. Systematic study of spatiotemporal dynamics of intense femtosecond laser pulses in BK-7 glass

    Indian Academy of Sciences (India)

    Ram Gopal; V Deepak; S Sivaramakrishnan

    2007-04-01

    In this paper we present a systematic study of the spatial and temporal effects of intense femtosecond laser pulses in BK-7 over a broad range of input powers, 1–1000 times the critical power for self-focusing (cr) by numerically solving the nonlinear Schrödinger equation (NLS). Most numerical studies have not been extended to such high powers. A clear-cut classification of spatio-temporal dynamics up to very high powers into three regimes – the group-velocity dispersion (GVD) regime, the ionization regime and the dominant plasma regime – as done here, is a significant step towards a better understanding. Further, we examine in detail the role of GVD in channel formation by comparing BK-7 to an `artificial' medium. Our investigations bring forth the important observation that diffraction plays a minimal role in the formation of multiple cones and that plasma plays a diffraction-like role at very high powers. A detailed study of the spatio-temporal dynamics in any condensed medium over this range of powers has not been reported hitherto, to the best of our knowledge. We also suggest appropriate operational powers for various applications employing BK-7 on the basis of our results.

  13. Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation

    OpenAIRE

    Xin, Wenkuan; Soder, Rupal P; Cheng, Qiuping; Eric S. Rovner; Petkov, Georgi V.

    2012-01-01

    The large conductance voltage- and Ca2+-activated K+ (BK) channel is a major regulator of detrusor smooth muscle (DSM) excitability and contractility. Recently, we showed that nonselective phosphodiesterase (PDE) inhibition reduces guinea pig DSM excitability and contractility by increasing BK channel activity. Here, we investigated how DSM excitability and contractility changes upon selective inhibition of PDE type 1 (PDE1) and the underlying cellular mechanism involving ryanodine receptors ...

  14. Análisis del perfil de los estudiantes de enfermería en Polonia relacionado con la donación y trasplante de órganos

    OpenAIRE

    Mikla, Marzena

    2016-01-01

    Introducción y objetivos: El trasplante de órganos es, en muchos casos, el único método alternativo terapéuticamente eficaz. El proceso de donación y trasplante conlleva la participación de numerosos profesionales de salud, tanto a nivel hospitalario como extrahospitalario. Actitudes positivas o negativas hacia el mismo, trasmitidas por enfermeras, médicos y otros profesionales de la salud, influyen de forma convincente y definitiva en las familias que pasan por la terrible experiencia de...

  15. Análisis del perfil de los estudiantes de enfermería en Polonia relacionado con la donación y trasplante de órganos

    OpenAIRE

    Mikla, Marzena

    2016-01-01

    Introducción y objetivos: El trasplante de órganos es, en muchos casos, el único método alternativo terapéuticamente eficaz. El proceso de donación y trasplante conlleva la participación de numerosos profesionales de salud, tanto a nivel hospitalario como extrahospitalario. Actitudes positivas o negativas hacia el mismo, trasmitidas por enfermeras, médicos y otros profesionales de la salud, influyen de forma convincente y definitiva en las familias que pasan por la terrible experiencia de una...

  16. The impact of surveillance and rapid reduction in immunosuppression to control BK virus-related graft injury in kidney transplantation.

    Science.gov (United States)

    Elfadawy, Nissreen; Flechner, Stuart M; Liu, Xiaobo; Schold, Jesse; Tian, Devin; Srinivas, Titte R; Poggio, Emilio; Fatica, Richard; Avery, Robin; Mossad, Sherif B

    2013-08-01

    We prospectively screened 609 consecutive kidney (538) and kidney-pancreas (71) transplant recipients for BK viremia over a 4-year interval using polymerase chain reaction viral load detection and protocol kidney biopsies. We found that BK viremia is common at our center: total cases 26.7%, cases during first year 21.3% (mean 4 months), and recipients with ≥ 10 000 copies/ml 12.3%. We found few predictive clinical or demographic risk factors for any BK viremia or viral loads ≥ 10,000 copies/ml, other than prior treatment of biopsy confirmed acute rejection and/or higher immunosuppressive blood levels of tacrolimus (P = 0.001) or mycophenolate mofetil (P = 0.007). Viral loads at diagnosis (185 000 copies/ml at diagnosis were predictive of BK virus-associated nephropathy (BKVAN; OR: 113.25, 95% CI: 17.22-744.6, P < 0.001). Surveillance for BK viremia and rapid reduction of immunosuppression limited the incidence of BKVAN to 1.3%. The addition of leflunomide or ciprofloxacin to immunosuppressive dose reduction did not result in greater rates of viral clearance. These data support the role of early surveillance for BK viremia to limit the impact on transplant outcome, although the most effective schedule for screening awaits further investigation. PMID:23763289

  17. Algunos aspectos éticos de la donación y el trasplante Some ethical aspects of donation and transplantation

    Directory of Open Access Journals (Sweden)

    K. Martínez

    2006-08-01

    Full Text Available El consenso ético y legal en nuestro país basa la práctica de las donaciones y los trasplantes en diversos principios éticos, recogidos en la legislación, muy acordes con los cuatro principios de la bioética principialista: autonomía, beneficencia, no-maleficencia y justicia. El nivel de donaciones conseguido en nuestro medio podría, de hecho, estar relacionado con el estricto respeto de los mismos por parte de los profesionales sanitarios así como con la excelente organización del mundo del trasplante. Muchos han sido los retos científicos, técnicos y éticos a los que se ha tenido que dar respuesta para llegar a la situación actual del trasplante. Y muchos siguen siendo los retos actuales. En el artículo se analizan sólamente algunos, por su repercusión técnica, ética y social: los trasplantes de órganos de donante vivo, la solicitud pública de órganos, el mercado de órganos, los trasplantes de órganos no vitales (fundamentalmente el trasplante de cara, la utilización de células troncales y los bancos de células de cordón umbilical. El objetivo del escrito es el de enunciar los problemas éticos que estas nuevas prácticas despiertan para intentar sentar las bases de una deliberación moral que necesariamente ha de involucrar a toda la sociedad.Ethical and legal consensus in our country bases the practice of donations and transplants on different ethical principles, which are contained in the legislation, closely conforming to the four principles of principialist bioethics: autonomy, beneficence, non-maleficence, and justice. The level of donations achieved in our milieu might, in fact, be related to a strict respect for these principles by the health professionals, as well as to the excellent organisation of the transplant world. Many scientific, technical and ethical challenges have had to be met to reach the present state of the transplant. And there are many current challenges. The article only analyses some of

  18. Trasplante de progenitores hematopoyéticos con acondicionamiento de intensidad reducida: aplicabilidad en leucemia mieloide aguda y síndromes mielodisplásicos

    OpenAIRE

    Valcarcel Ferreiras, David

    2014-01-01

    El trasplante alogénico (Alo-TPH) es la única opción curativa en la mayoría de pacientes con leucemia mieloide aguda (LMA) y síndrome mielodisplásico (SMD) así como en otras enfermedades hematológicas neoplásicas y no neoplásicas. Sin embargo su aplicabilidad ha sido reducida por la toxicidad inherente al uso de dosis altas de quimioradioterapia utilizadas durante el acondicionamiento. El desarrollo de esquemas de acondicionamiento de menor intensidad, conocidos como acondicionamientos de int...

  19. Propuesta de un modelo experimental para la monitorización de la respuesta inmunitaria en pacientes sometidos a trasplante hepático

    OpenAIRE

    Cos Trullàs, Joan

    2009-01-01

    Actualmente, el trasplante hepático (TxH) es el tratamiento de numerosas enfermedades que abocan a una insuficiencia hepática aguda fulminante o, más frecuentemente, a una fase final de de una hepatopatía crónica irreversible. Los efectos secundarios asociados al empleo indiscriminado de drogas inmnunosupresoras y el hecho de que un 20% de los pacientes sometidos a TxH desarrollen tolerancia al injerto tras una retirada total de la inmunosupresión (tolerancia operacional) promueve una investi...

  20. Intervención psicológica en pacientes que deben someterse a un trasplante de médula ósea

    OpenAIRE

    Arranz, Pilar; Coca, Cristina; Bayés, Ramon; Rincón, Carola del; Hernández Navarro, Fernando

    2003-01-01

    Desde hace unas décadas los enfermos hemato-oncológicos o con tumores quimiosensibles cuentan con una nueva y esperanzadora línea de tratamiento denominada Trasplante de Médula Ósea (TMO). La aplicación de altas dosis de quimioterapia intensiva permite disminuir el riesgo de recaídas, prolongar la supervivencia y posibilitar la curación en un gran número de casos; sin embargo, someterse a este procedimiento supone afrontar múltiples y diversos estresores potenciales a corto, medio y largo pla...

  1. Papel de las células mesenquimales expandidas in vitro para mejorar el injerto en el contexto del trasplante hematopoyético

    OpenAIRE

    Carrancio Antón, Soraya

    2010-01-01

    [ES] El trasplante de progenitores hematopoyéticos (TPH) es un procedimiento terapéutico destinado a reconstituir el tejido hematopoyético del paciente, que generalmente presenta una insuficiencia medular o sufre una enfermedad neoplásica. Ya a finales del S.XIX, Brown-Sequard planteó la posibilidad de reconstituir la producción de células sanguíneas en casos de anemia con la administración de bazo de animales, crudo o cocido. Pero no fue hasta los años 50 cuando se consiguió r...

  2. Trasplante de médula ósea: abordaje de la Terapia Ocupacional = Transplant of bony marrow : boarding th Occupational Theapy

    OpenAIRE

    Alahmar Bianchin, M; Gomes Puga, GB; Caselle Paulino, G; Uemura Paulino, V

    2007-01-01

    ResumenEl trasplante de médula ósea (TMO) es una modalidad terapéutica que se utiliza en una variedad de enfermedades oncológicas y hematológicas, con el objetivo de prolongar la remisión completa o la cura de la enfermedad. La unidad de TMO del Hospital de Base de San José Del Río Preto - San Pablo, Brasil, cuenta con un equipo formado por doctores, enfermeros, terapeuta ocupacional, psicólogo, nutricionista y asistente social. El estudio presente tiene por objetivo describir la importancia ...

  3. Enfermedad pulmonar obstructiva crónica y trasplante pulmonar. Resultados y análisis de factores pronósticos

    OpenAIRE

    Cerón Navarro, Jose A.

    2012-01-01

    Estudio observacional, analítico y retrospectivo de los pacientes diagnosticados de enfermedad pulmonar obstructiva crónica (EPOC) sometidos a trasplante pulmonar (TP) en el Hospital Universitario La Fe desde 1991 hasta 2008. Tras la recogida de variables relacionadas con el receptor, el donante, el procedimiento quirúrgico y el seguimiento, precoz y a largo plazo, se obtuvo una muestra de 107 pacientes, con un predominio de varones en torno a los 52 años de edad. La capacidad funcional r...

  4. Factores pronósticos de complicaciones postoperatorias en el trasplante hepático Prognostic factors associated with postoperative complications in liver transplantation

    OpenAIRE

    A. Rodríguez-Ariza; A. Monrobel; E. Martínez-Galisteo; C. Alicia Padilla; Bárcena, J.A.; Fraga, E.; G. Costán; Barrera, P; A. Poyato; Montero, J.L.; P. López-Cillero; J Muntané; de la Mata, M

    2008-01-01

    Objetivo: la evolución postoperatoria de los pacientes sometidos a trasplante hepático ortotópico (THO) se encuentra frecuentemente asociada a la aparición de diversas complicaciones tales como disfunción renal, rechazo agudo, infecciones y complicaciones neurológicas. Estas complicaciones constituyen las causas más significativas de morbilidad y mortalidad tempranas en pacientes que reciben un THO. El propósito del presente estudio es la identificación de factores relacionados con las distin...

  5. Rechazo agudo subclínico en el paciente con trasplante renal Acute subclinical rejection in the patient with kidney transplant

    OpenAIRE

    Alexis Pérez Rodríguez; Alexander Mármol Sóñora; Juan C. Pérez de Prado Valdivia; Ángel Fong Baltar; Silvia Fernández-Vega Garcías

    2008-01-01

    El rechazo agudo subclínico al riñón trasplantado es el proceso de rechazo sin expresión clínica, aparece entre un tercio y la mitad de los pacientes que reciben trasplante renal, por lo general en los primeros 3 meses de postrasplante. En la actualidad, la principal causa de pérdida de riñones trasplantados es el rechazo crónico ya que a pesar del surgimiento de nuevos inmunosupresores y de la disminución del rechazo agudo no se ha logrado alcanzar un impacto significativo de la supervivenci...

  6. Cooperación jurídica internacional en materia de donación y trasplante de organos: hacia un nuevo paradigma

    OpenAIRE

    Joaquín Cayón de las CUEVAS; Guillermina Navarro CABALLERO; María Elena Balmori GÓMEZ

    2013-01-01

    RESUMEN El trasplante de órganos puede contribuir decisivamente no sólo a salvar vidas sino también a mejorar la calidad de las mismas. Sin embargo, el problema fundamental al que se enfrenta este tipo de terapias es la desproporción entre la oferta y la demanda. El número de donantes es, por definición, muy limitado y la donación puede no resultar posible por motivos diversos tales como la falta de autorización familiar o la ausencia de condiciones necesarias. Así las cosas, la difi...

  7. Pabellón de trasplantes en el hospital general de Edimburgo, Gran Bretaña

    Directory of Open Access Journals (Sweden)

    Womersley, P.

    1970-11-01

    Full Text Available The set of buildings includes a medical wing, an administrative wing, and a slightly elevated passage, which connects the Nuffield Foundation with the Hospital, through which patients and donants are taken from the Hospital to the Pavillion. The body of the building, which is tower shaped, has stairs, a lift, water tanks; and in the semi-basement there are mechanical, sanitary, and air conditioning installations. This pavillion has been specially designed to carry out human transplants, mainly kidneys, and meets present complex technical needs in this branch of surgery. From the aesthetic aspect, the total designs gives the visitor the impression of safety and airiness, and induces a sensation of confidence.El conjunto construido consta de: un ala médica; un ala administrativa; y un paso ligeramente elevado, que une Nuffield con el Hospital, utilizado para el traslado de pacientes y donantes desde el Hospital al Pabellón. El cuerpo de edificio, con aspecto de «torre», contiene: la escalera, el ascensor, el depósito de agua, etc.; el semisótano alberga: los equipos mecánicos y los servicios de las instalaciones sanitarias, aire acondicionado, etc. Ha sido especialmente diseñado para realizar operaciones de trasplante de órganos humanos, en particular de riñon, y satisface adecuadamente las complejas exigencias técnicas que reclamaban los recientes avances en esta rama de la cirugía. Desde el punto de vista estético, el conjunto construido produce en el espectador una sensación segura y etérea, que lo hace sumamente atractivo.

  8. Bk and Cf chromatographic separation and ²⁴⁹Bk/²⁴⁸Cm and ²⁴⁹Cf/²⁴⁸Cm elemental ratios determination by inductively coupled plasma quadrupole mass spectrometry.

    Science.gov (United States)

    Gourgiotis, A; Isnard, H; Nonell, A; Aubert, M; Stadelmann, G; Dupont, E; AlMahamid, I; Tiang, G; Rao, L; Lukens, W; Cassette, P; Panebianco, S; Letourneau, A; Chartier, F

    2013-03-15

    The French Atomic Energy Commission has carried out several experiments for the study of minor-actinide transmutation processes in high intensity thermal neutron flux. In this context a Cm sample enriched in (248)Cm (∼97%) was irradiated in a thermal neutron flux at the High Flux Reactor (HFR) of the Laue-Langevin Institute (ILL). The precise and accurate determination of Cf isotope ratios and of (249)Bk/(248)Cm and (249)Cf/(248)Cm elemental ratios in the (248)Cm irradiated sample is crucial for the calculation of actinide neutron capture cross-sections. This work describes an analytical procedure for the separation and the isotope ratio measurement of Bk and Cf in the irradiated sample. The Bk and Cf separation is based on a lanthanides separation protocol previously developed by the laboratory. Well-defined retention times for Bk and Cf were obtained by coupling the Ionic Chromatography (IC) with an ICP-QMS. All conditions of element separation by IC and the different steps of the analytical protocol in order to obtain the isotopic and elemental ratios are presented. Relative uncertainties of Cf isotopic ratios range from 0.3% to 0.5% and the uncertainty of the (249)Bk/(248)Cm and (249)Cf/(248)Cm elemental ratios are respectively 6.1% and 3.2%. This level of uncertainty for both isotopic and elemental ratios is in perfect agreement with the requirement for transmutation studies. PMID:23598093

  9. Ca2+- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in lateral chain

    OpenAIRE

    Bukiya, Anna N.; Patil, Shivaputra; Li, Wei; Miller, Duane; Dopico, Alex M.

    2012-01-01

    Large conductance, calcium- and voltage-gated potassium (BK) channels regulate various physiological processes and represent an attractive target for drug discovery. Numerous BK channel activators are available. However, these agents usually interact with the ubiquitously distributed channel-forming subunit and thus cannot selectively target a particular tissue. Here, we performed structure-activity relationship study of lithocholic acid (LCA), a cholane that activates BK channels via the acc...

  10. Intracellular segment between transmembrane helices S0 and S1 of BK channel α subunit contains two amphipathic helices connected by a flexible loop

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Pan [Hefei National Laboratory of Microscale Physical Sciences, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027 (China); High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); Li, Dong; Lai, Chaohua [Hefei National Laboratory of Microscale Physical Sciences, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027 (China); Zhang, Longhua, E-mail: zlhustc@ustc.edu.cn [Hefei National Laboratory of Microscale Physical Sciences, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027 (China); Tian, Changlin, E-mail: cltian@ustc.edu.cn [Hefei National Laboratory of Microscale Physical Sciences, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027 (China); High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China)

    2013-08-02

    Highlights: •The loop between S0 and S1 of BK channel was overexpressed and purified in DPC. •NMR studies indicated BK-IS1 contained two helices connected by a flexible loop. •Mg{sup 2+} titration of BK-IS1 indicated two possible binding sites of divalent ions. -- Abstract: The BK channel, a tetrameric potassium channel with very high conductance, has a central role in numerous physiological functions. The BK channel can be activated by intracellular Ca{sup 2+} and Mg{sup 2+}, as well as by membrane depolarization. Unlike other tetrameric potassium channels, the BK channel has seven transmembrane helices (S0–S6) including an extra helix S0. The intracellular segment between S0 and S1 (BK-IS1) is essential to BK channel functions and Asp99 in BK-IS1 is reported to be responsible for Mg{sup 2+} coordination. In this study, BK-IS1 (44–113) was over-expressed using a bacterial system and purified in the presence of detergent micelles for multidimensional heteronuclear nuclear magnetic resonance (NMR) structural studies. Backbone resonance assignment and secondary structure analysis showed that BK-IS1 contains two amphipathic helices connected by a 36-residue loop. Amide {sup 1}H–{sup 15}N heteronuclear NOE analysis indicated that the loop is very flexible, while the two amphipathic helices are possibly stabilized through interaction with the membrane. A solution NMR-based titration assay of BK-IS1 was performed with various concentrations of Mg{sup 2+}. Two residues (Thr45 and Leu46) with chemical shift changes were observed but no, or very minor, chemical shift difference was observed for Asp99, indicating a possible site for binding divalent ions or other modulation partners.

  11. Viabilitas dan Kemampuan Bakteri Kitinolitik Bacillus sp. BK17 dalam Formulasi Tablet untuk Mengurangi Layu Fusarium pada Benih Cabai Merah (Capsicum annuum L.)

    OpenAIRE

    Sitohang, Arance Yoane Itoi Imaulina

    2015-01-01

    Chitinolytic bacteria Bacillus sp. BK17 has been known to inhibit the growth of Fusarium oxysporum on chili seeds. Bacterial cell viability is an important factor in using the cell for biological control. This study was aimed to evaluate viability of chitinolytic bacteria Bacillus sp. BK17 and its potential in tablet formulation as a biological control againstF. oxysporum. Viability of Bacillus sp. BK17 cell was reduced in 40 days of storage. Bacillus sp. BK17 in tablet formulation was able t...

  12. LA VISIÓN DEL PERSONAL DE SALUD SOBRE LA DONACIÓN Y EL TRASPLANTE DE ÓRGANOS: UNA REVISIÓN DE LA LITERATURA

    Directory of Open Access Journals (Sweden)

    Francisco Javier Mercado-Martínez

    2015-01-01

    Full Text Available El objetivo de este estudio fue revisar los estudios empíricos sobre la visión del personal de salud respecto a la donación y trasplante de órganos. Se hizo una revisión panorámica de la literatura en español, inglés y portugués; realizándose la búsqueda en dos buscadores y ocho bases de datos. El periodo abarca de 1985 al 2013. Se hizo análisis de contenido y frecuencias. De 316 artículos identificados, 248 fueron seleccionados. Según los hallazgos, los trabajos se concentraron en términos temporales y espaciales; predominando aquellos con metodologías cuantitativas. Las publicaciones priorizaron la perspectiva del personal médico y enfermería sobre las de otros actores, como directivos y coordinadores de donación. Las actitudes del personal sanitario hacia la donación de órganos de fallecido fue el tema más estudiado. Se concluye que una producción creciente de tipo cuantitativo analiza la perspectiva de médicos y enfermeras sobre la donación y trasplante de órganos de fallecido.

  13. Erbium-doped ion-exchanged waveguide lasers in BK-7 glass

    OpenAIRE

    Feuchter, T.; Mwarania, E.K.; Wang, J.; Reekie, L.; J. S. Wilkinson

    1992-01-01

    Ion exchange in glass is a simple, flexible, technique to realize optical fiber compatible planar waveguide devices. Recently, neodymium-doped waveguide lasers operating at 1060 and 1300 nm have been demonstrated in this technology. Lasers operating at 1540 nm are desirable for telecommunication applications and we report here, for the first time, ion-exchanged waveguide lasers in erbium-doped glass emitting at this wavelength. Lasers in BK-7 glass doped with 0.5 wt% Er2O3 and pumped at 980 n...

  14. Low-loss waveguides fabricated in BK7 glass by high repetition rate femtosecond fiber laser

    International Nuclear Information System (INIS)

    For the first time femtosecond-laser writing has inscribed low-loss optical waveguides in Schott BK7 glass, a commercially important type of borosilicate widely used in optical applications. The use of a variable repetition rate laser enabled the identification of a narrow processing window at 1 MHz repetition rate with optimal waveguides exhibiting propagation losses of 0.3 dB/cm and efficient mode matching to standard optical fibers at a 1550 nm wavelength. The waveguides were characterized by complementary phase contrast and optical transmission microscopy, identifying a micrometer-sized guiding region within a larger complex structure of both positive and negative refractive index variations

  15. Preliminary study on rotary ultrasonic machining of Bk-7 optical glass rod

    International Nuclear Information System (INIS)

    This paper presents an experimental observation on rotary ultrasonic machining (RUM) of BK7 optical glass rod. BK7 is a common technical optical glass for high quality optical components due to its high linear optical transmission in the visible range and is chemically stable. RUM is a hybrid machining process that combines the material removal mechanisms of diamond grinding and ultrasonic machining (USM) and it is non-thermal, non-chemical, creates no change in the microstructure, chemical or physical properties of the work piece. In the RUM, a controlled static load is applied to the rotating core drill with metal bonded diamond abrasive and is ultrasonically vibrated in the axial direction. A water-soluble coolant was used to cool the tool and sample during machining processes. By using DOE (Design of Experiment) approach, the effect of spindle speed and feed rate to the ultrasonic machinability had been developed. The main effects and two-factor interactions of process parameters (spindle speed) and feed rate) on output variables (MRR, surface roughness, opaqueness, chipping thickness and chipping size) are studied. (author)

  16. BK Lyncis: The Oldest Old Nova?... And a Bellwether for Cataclysmic-Variable Evolution

    CERN Document Server

    Patterson, Joseph; Kemp, Jonathan; de Miguel, Enrique; Krajci, Thomas; Foote, Jerry; Hambsch, Franz-Josef; Campbell, Tut; Roberts, George; Cejudo, David; Dvorak, Shawn; Vanmunster, Tonny; Koff, Robert; Skillman, David; Harvey, David; Martin, Brian; Rock, John; Boyd, David; Oksanen, Arto; Morelle, Etienne; Ulowetz, Joseph; Kroes, Anthony; Sabo, Richard; Jensen, Lasse

    2012-01-01

    We summarize the results of a 20-year campaign to study the light curves of BK Lyncis, a nova-like star strangely located below the 2-3 hour orbital period gap in the family of cataclysmic variables. Two apparent "superhumps" dominate the nightly light curves - with periods 4.6% longer, and 3.0% shorter, than P_orb. The first appears to be associated with the star's brighter states (V~14), while the second appears to be present throughout and becomes very dominant in the low state (V~15.7). Starting in the year 2005, the star's light curve became indistinguishable from that of a dwarf nova - in particular, that of the ER UMa subclass. Reviewing all the star's oddities, we speculate: (a) BK Lyn is the remnant of the probable nova on 30 December 101, and (b) it has been fading ever since, but has taken ~2000 years for the accretion rate to drop sufficiently to permit dwarf-nova eruptions. If such behavior is common, it can explain other puzzles of CV evolution. One: why the ER UMa class even exists (because all...

  17. Risk Factors for the Development of BK Virus Nephropathy in Renal Transplant Recipients.

    Science.gov (United States)

    Pai, D; Mann, D M; Malik, A; Hoover, D R; Fyfe, B; Mann, R A

    2015-10-01

    The BK polyoma virus has, in recent years, become a significant cause of renal allograft dysfunction and failure. Among 260 adult kidney transplant recipients, those with biopsy-proven BK virus nephropathy (BKVN) were compared with those without BKVN with regard to gender, age, race, rejection episodes, time on dialysis, number of organs transplanted, HLA match, live donor versus deceased donor, cold ischemia time, delayed graft function, cytomegalovirus (CMV) serostatus of donor and recipient, induction therapy, and maintenance immunosuppression. Episodes of rejection (35.7% of patients with BKVN vs 8.5% of patients without BKVN; P = .01), transplantation of >1 organ (35.7% of patients with BKVN vs 9.0% of patients without BKVN; P = .01), positive CMV serology in both donor and recipient (71.4% of patients with BKVN vs 41.1% of patients without BKVN; P = .03), and a greater cumulative dose of daclizumab use at the time of induction (2.24 ± 0.05 mg/kg in patients with BKVN vs 2.03 ± 0.14 mg/kg in patients without BKVN; P = .04) were statistically significant risk factors for the development of BKVN. Those who developed BKVN received a higher mean cumulative dose of rabbit antithymoglobulin for induction therapy, but that difference failed to achieve statistical significance (P = .07). PMID:26518952

  18. On the Operator ⨁Bk Related to Bessel Heat Equation

    Directory of Open Access Journals (Sweden)

    Wanchak Satsanit

    2010-01-01

    Full Text Available We study the equation (∂/∂tu(x,t=c2⊕Bku(x,t with the initial condition u(x,0=f(x for x∈Rn+. The operator ⊕Bk is the operator iterated k-times and is defined by ⊕Bk=((∑i=1pBxi4-(∑j=p+1p+qBxi4k, where p+q=n is the dimension of the Rn+, Bxi=∂2/∂xi2+(2vi/xi(∂/∂xi, 2vi=2αi+1, αi>-1/2, i=1,2,3,…,n, and k is a nonnegative integer, u(x,t is an unknown function for (x,t=(x1,x2,…,xn,t∈Rn+×(0,∞, f(x is a given generalized function, and c is a positive constant. We obtain the solution of such equation, which is related to the spectrum and the kernel, which is so called Bessel heat kernel. Moreover, such Bessel heat kernel has interesting properties and also related to the kernel of an extension of the heat equation.

  19. A new precise mass for the progenitor of the Type IIP SN 2008bk

    CERN Document Server

    Maund, J R; Ramirez-Ruiz, E; Eldridge, J J

    2013-01-01

    The progenitor of the Type IIP SN 2008bk was discovered in pre-explosion g'r'i'IYJHKs images, acquired with European Southern Observatory Very Large Telescope FORS, HAWK-I and ISAAC instruments and the Gemini GMOS-S instrument. The wealth of pre-explosion observations makes the progenitor of this SN one of the best studied, since the detection of the progenitor of SN1987A. Previous analyses of the properties of the progenitor were hampered by the limited quality of the photometric calibration of the pre-explosion images and the crowded nature of the field containing the SN. We present new late-time observations of the site of SN2008bk acquired with identical instrument and filter configurations as the pre-explosion observations, and confirm that the previously identified red supergiant star was the progenitor of this SN and has now disappeared. Image subtraction techniques were used to conduct precise photometry of the now missing progenitor, independently of blending from any nearby stars. The nature of the ...

  20. The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor.

    Science.gov (United States)

    Filippelli-Silva, Rafael; Martin, Renan P; Rodrigues, Eliete S; Nakaie, Clovis R; Oliveira, Laerte; Pesquero, João B; Shimuta, Suma I

    2016-04-01

    Bradykinin (BK) is a nonapeptide important for several physiological processes such as vasodilatation, increase in vascular permeability and release of inflammatory mediators. BK performs its actions by coupling to and activating the B2 receptor, a family A G-protein coupled receptor. Using a strategy which allows systematical monitoring of BK R1 and R9 residues and B2 receptor acidic residues Glu5.35(226) and Asp6.58(298), our study aims at clarifying the BK interaction profile with the B2 receptor [receptor residue numbers are normalized according to Ballesteros and Weinstein, Methods Neurosci. 25 (1995), pp. 366-428) followed by receptor sequence numbering in brackets]. N- and C-terminal analogs of BK (-A1, -G1, -K1, -E1 and BK-A9) were tested against wild type B2, Glu5.35(226)Ala and Asp6.58(298)Ala B2 mutant receptors for their affinity and capability to elicit responses by mechanical recordings of isolated mice stomach fundus, measuring intracellular calcium mobilization, and competitive fluorimetric binding assays. BK showed 2- and 15-fold decreased potency for Glu5.35(226) and Asp6.58(298) B2 mutant receptors, respectively. In B2-Glu5.35(226)Ala BK analogs showed milder reduction in evaluated parameters. On the other hand, in the B2-Asp6.58(298)Ala mutant, no N-terminal analog was able to elicit any response. However, the BK-A9 analog presented higher affinity parameters than BK in the latter mutant. These findings provide enough support for defining a novel interaction role of BK-R9 and Asp6.58(298) receptor residues. PMID:26584354

  1. A single-center epidemiological study of BK virus infection and analysis of risk factors in patients with renal transplantation

    Directory of Open Access Journals (Sweden)

    Ji-gang LI

    2014-10-01

    Full Text Available Objective To investigate the epidemiological characteristics of BK virus (BKV infection in living renal transplantation patients, and analyze the risk factors of BKV infection and BKV nephropathy (BKVN. Methods The BKV DNA load in urine and blood samples of 43 renal transplant recipients, who had received renal transplantation in 309 Hospital from Feb. 2012 to Feb. 2013, was determined at preoperative period and 0.5, 1, 3, 6, 9, 12 and 15 months after transplantation. Meanwhile, the biopsy of grafted kidney was performed in those patients with continuously elevated serum creatinine and those with higher BKV DNA load. Patients were divided into 3 groups as follows according to the test results: BK viruria group, BK viremia group and pathologically diagnosed BKVN group. Data of each group were then recorded, including gender, age, postoperative diabetes (PTDM, acute rejection (AR, delayed recovery of graft function (DGF, postoperative pulmonary infection, preoperative immune induction therapy, postoperative immunosuppressive regimen, and other information. The risk factors for postoperative BKV infection and BKVN were analyzed. Results After an average of 15-month follow-up, it was found that the incidence of BKV viruria was 46.5%, that of BKV viremia was 14.0%, and that of BKVN was 2.3%. Sixth month after transplantation was found to be the peak time of viruria and viremia. FK506 was significantly associated with viremia in living donor renal transplantation. The immunosuppressive regimen was the immune related independent risk factor for BK viremia developing BKVN after living renal transplantation. Conclusion The incidence of BK viremia and BKVN is lower in living donor renal transplantation than in cadaver renal transplantation, but that of viruria is similar in both groups. Immunosuppressive scheme based on FK506 is an immune related independent risk factor leading to BK viremia proceeding to BKVN in living donor kidney

  2. Trasplante renal y disminución de la mortalidad en los programas de diálisis crónica

    Directory of Open Access Journals (Sweden)

    Walter G. Douthat

    2014-02-01

    Full Text Available El trasplante renal (TR presenta mejor supervivencia, calidad de vida y costos que la diálisis en la insuficiencia renal crónica (IRC. Estudiamos pacientes en diálisis que recibieron TR durante 2010, las causas de finalización del tratamiento y la supervivencia en diálisis. Evaluamos si criterios más amplios para la aceptación de trasplantes hubieran afectado los resultados del procedimiento en ese período. Incluimos 118 pacientes en diálisis, edad media 56.9 ± 18.4 años, tiempo en diálisis 45.5 ± 59.6 meses, 35 (30% presentaban diabetes como causa de IRC, y 58 (49% estaban en espera del TR. Treinta y cuatro finalizaron diálisis, 18 por TR y 12 por fallecimiento. Las principales causas de muerte fueron cardiovasculares, 6 (50% e infecciones, 2 (17%. La supervivencia al año fue 85% para el grupo total, 98% para los pacientes inscriptos en lista de espera y 72% para no inscriptos. Durante 2010 se realizaron 88 TR (62 con donantes cadavéricos [DC], 18 donantes vivos y 8 dobles trasplantes páncreas-riñón. Los receptores de DC tenían en promedio 50.7 años, 67 meses en diálisis, 8 (13% eran diabéticos, 12 (20% con TR previos y 3 cross match contra panel de anticuerpos > 20%. Los donantes tenían edad media 45 años, 28 (45% con criterios expandidos y 27.7 h de isquemia fría. A los 11.4 meses de seguimiento, 13 (21% presentó rechazo agudo, la supervivencia para injerto fue de 88% y 93% para pacientes. La principal causa de finalización de diálisis fue TR, sin detectarse que el empleo de DC afectara la supervivencia del TR.

  3. PENGEMBANGAN INSTRUMEN ASESMEN KEBUTUHAN PERKEMBANGAN UNTUK PENYUSUNAN KURIKULUM DAN EVALUASI PROGRAM BK

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    Gendon Barus

    2013-01-01

    Full Text Available Penelitian pengembangan ini bertujuan menghasilkan instrumen asesmen kebutuhan peserta didik, disebut Invantori Kebutuhan Perkembangan Murid (IKPM. Penelitian mengikuti model Plomp (1999 dengan lima fase. Reliabilitas instrumen diestimasi dengan teknik Alpha Cronbach, validitas isi diperiksa oleh pakar dan telaah praktisi melalui FGD. Validitas empirik dan kecocokan model pengukuran dibuktikan dengan analisis faktor konfirmatori (CFA dengan program Lisrel 8.30. Telaah praktisi melibatkan 60 orang guru kelas V dan VI SD dalam dua tahap FGD, sedangkan uji coba empirik dan implementasi melibatkan murid kelas V dan VI. Hasil penelitian pengembang-an ini adalah: 1 IKPM dapat digunakan untuk menghimpun data kebutuhan perkembangan sebagai dasar penyusunan kurikulum bimbingan dan melaksanakan evaluasi program, bimbingan dan alat ukur evaluasi program bimbingan klasikal di sekolah dasar dan 2 teridentifikasi butir-butir kebutuhan per-kembangan murid yang intens dan sangat intens untuk dipenuhi melalui layanan bimbingan klasikal. Kata kunci: instrumen asesmen kebutuhan, kurikulum bimbingan, instrument evaluasi program BK ______________________________________________________________ DEVELOPMENT OF DEVELOPMENTAL NEEDS ASSESSMENT INSTRUMENT FOR CURRICULUM ARRANGEMENT AND EVALUATION OF BK PROGRAM Abstract The goal of this research is to produce a developmental needs assessment instrument, called Student’s Developmental Needs Inventory, which can be use to reveal the needs of students in elementary school. The research method follows the model of Research and Development (R & D by Plomp (1999 with five phases. The instrument which is developed in this study guidance and counseling (Bimbingan Konseling, BK in elementary school. Instrument reliability is estimated using by Alpha Cronbach technique, it content validity is checked by experts judgment and practitioner’s assessment with FGD technique. Furthermore, empirical validity and the goodness of fit

  4. Cumplimiento del tratamiento en el trasplante renal pediátrico Compliance with treatment in paediatric renal transplant

    Directory of Open Access Journals (Sweden)

    Paloma Conde García

    2010-09-01

    Full Text Available Son numerosas las causas del incumplimiento terapéutico en pacientes pediátricos con trasplante renal. El objetivo de este trabajo fue, identificar las dificultades que presentaban las familias y los pacientes para el correcto cumplimiento del tratamiento en receptores de trasplante renal pediátrico. Para ello se realizó un estudio observacional descriptivo y transversal con la participación de 41 pacientes de edades comprendidas entre los 5 y 18 años. Como instrumento de medida se diseñó una encuesta con preguntas cerradas sobre aspectos demográficos, conocimientos y actitudes con respecto al tratamiento recibido, autonomía o dependencia en la administración, adhesión y cansancio del paciente y cuidador. Se realizó la encuesta al paciente y cuidador principal. El porcentaje de incumplimiento fue del 12,1% observándose mayor incumplimiento en receptores adolescentes. Los pacientes que presentaron rechazo de injerto fueron 14, de los cuales, 9 por causa inmunológica y 5 por abandono de tratamiento. El 90% de los pacientes manifestaban haber recibido una información completa respecto a conocimientos e importancia de la toma. Presentaban un correcto conocimiento de los inmunosupresores, el horario y la adherencia de la toma. El 18% manifestaron desconocimiento sobre los efectos secundarios. Las razones para dejar de tomar la medicación fueron principalmente el cansancio del paciente o cuidador (70% y olvido en un 50%, de los cuales el 22% presentaron olvido sólo en una ocasión. En cuanto a las incidencias en la toma del tratamiento, se observaron diarreas (50% y vómitos (42%. La mayoría de los pacientes tienen supervisión de la toma de medicación por parte de un cuidador, que habitualmente la madre. Todos los pacientes estudiados disponían de ayuda social (100% y financiación del tratamiento. En general podemos decir que los pacientes se sienten motivados a seguir el tratamiento, pero se sienten agotados debido al largo

  5. Resultados clínicos de trasplantes de riñón en pacientes con enfermedad renal en etapa terminal secundaria a nefritis lupus, enfermedad poliquística renal y nefropatía diabética

    Directory of Open Access Journals (Sweden)

    John Fredy Nieto-Ríos

    2016-04-01

    Full Text Available Antecedentes:Pacientes con nefritis lúpica pueden progresar a enfermedad renal crónica terminal (10-22%; en estos pacientes el trasplante renal debe ser considerado como la terapia de elección. Objetivo: Evaluar los desenlaces clínicos de un grupo de pacientes con enfermedad renal crónica terminal por nefropatía lúpica, enfermedad renal poliquística y nefropatía diabética que fueron sometidos a trasplante renal en el Hospital Pablo Tobón Uribe.Métodos:Estudio retrospectivo, descriptivo, realizado en un solo centro de trasplante renal, durante el período 2005-2013.Resultados:Se evaluaron 136 pacientes: 27 con nefritis lúpica (19.9%, 31 con enfermedad renal poliquística (22.8% y 78 con nefropatía diabética (57.4%. La supervivencia del injerto a uno, tres y cinco años fue de de 96.3%, 82.5% y 82.5% en nefropatía lúpica, 90%, 86% y 76.5% en enfermedad renal poliquística y 91.7%, 80.3% y 67.9% en nefropatía diabética respectivamente, sin diferencias estadísticas significativas (Long Rank test= 0.488. La tasa de recurrencia de nefritis lúpica posterior al trasplante renal fue de 0.94%/persona-año. Tener lupus vs diabetes o enfermedad renal poliquística no fue un factor de riesgo para disminución del tiempo de supervivencia del injerto (Hazard ratio= 1.43; 95% IC= 0.52-3.93.Conclusiones:Los pacientes enfermedad renal crónica terminal secundaria a nefritis lúpica, que son llevados a trasplante renal tienen tasas de éxito similar en cuanto a supervivencia del injerto y del paciente, al compararlos con otras enfermedades renales. La tasa de complicaciones y el riesgo de recurrencia de la nefropatía lúpica son bajos. El trasplante renal debe ser considerado como la terapia de elección para los pacientes con enfermedad renal crónica estadio terminal secundaria a nefritis lúpica.

  6. Electron microscopic features of a brain tumor induced in hamster by BK virus, a human papova virus.

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    Tsuboi,Masahiro

    1979-12-01

    Full Text Available In order to locate the target cells for malignant transformation by BK virus (a human papova virus in hamster brain, electron microscopic observation of tumor originally induced in hamster brain by BK virus was performed. With light microscopy, the BK virus-induced tumor (Vn 17 bore a close resemblance to human malignant ependymoma. Under the electron microscope, numerous microvilli and few cilia were visible on the surface of the tumor cells. These tumor cells were joined to each other by desmosomes. Gap junctions were not observed. Multilayered cuboidal cells were observed around the lumen and blood vessels in the tumor. With regard to fine structure, three types of Vn 17 cells were recognized; ependymal like cells, tanycytes with prominent cell processes, and undifferentiated cells with few cytoplasmic organelles. There was no basal lamina between the ependymal cells and the connective tissue stroma. The Vn 17 cells showed some similarity to the ultrastructural features of the epemdymal cells of newborn rabbits, suggesting that the target cells for Vn 17 may be cells related to ependyma. Malignant transformation of the cells would be initiated in the early stages after BK virus inoculation into the brain of newborn hamsters.

  7. Draft Genome Sequence of an Invasive Multidrug-Resistant Strain, Pseudomonas aeruginosa BK1, Isolated from a Keratitis Patient

    KAUST Repository

    Jeganathan, Lakshmi Priya

    2014-03-27

    Pseudomonas aeruginosa infections are difficult to treat due to the presence of a multitude of virulence factors and antibiotic resistance. Here, we report the draft genome sequence of P. aeruginosa BK1, an invasive and multidrug-resistant strain, isolated from a bacterial keratitis patient in southern India.

  8. Successful hyperbaric oxygen therapy for refractory BK virus-associated hemorrhagic cystitis after cord blood transplantation.

    Science.gov (United States)

    Hosokawa, K; Yamazaki, H; Nakamura, T; Yoroidaka, T; Imi, T; Shima, Y; Ohata, K; Takamatsu, H; Kotani, T; Kondo, Y; Takami, A; Nakao, S

    2014-10-01

    BK virus-associated hemorrhagic cystitis (BKV-HC) is a common and major cause of morbidity in recipients of allogeneic hematopoietic stem cell transplantation. A 32-year-old woman developed severe BKV-HC on day 24 after cord blood transplantation (CBT). Despite supportive therapies - such as hyperhydration, forced diuresis, and urinary catheterization - macroscopic hematuria and bladder irritation persisted for over a month. Hyperbaric oxygen (HBO) therapy at 2.1 atmospheres for 90 min per day was started on day 64 after CBT. Macroscopic hematuria resolved within a week, and microscopic hematuria was no longer detectable within 2 weeks. Hematuria did not recur after 11 sessions of HBO therapy, and no significant side effects were observed during or after treatment. HBO therapy could thus be useful in controlling refractory BKV-HC after CBT. PMID:25040402

  9. Mathematical modeling of surface roughness in magnetic abrasive finishing of BK7 optical glass.

    Science.gov (United States)

    Pashmforoush, Farzad; Rahimi, Abdolreza; Kazemi, Mehdi

    2015-10-01

    Magnetic abrasive finishing (MAF) is one of the advanced machining processes efficiently used to finish hard-to-machine materials. Simulation and modeling of the process is of particular importance to understand the mechanics of material removal and consequently achieve a high-quality surface with a minimum of surface defects. Hence, in this paper, we performed a numerical-experimental study to mathematically model the surface roughness during the MAF of BK7 optical glass. For this purpose, the initial roughness profile was estimated using fast Fourier transform (FFT) and a Gaussian filter. We obtained the final surface profile based on the material removal mechanisms and the corresponding chipping depth values evaluated by finite element analysis. We then validated experimentally the simulation results in terms of the arithmetic average surface roughness (R(a ). The comparison between the obtained results demonstrates that the theoretical and experimental findings are in good agreement when predicting the parameters' effect on surface roughness behavior. PMID:26479596

  10. Hemorrhagic Cystitis due to BK Reactivation in a Young Female Treated for Hodgkin-Disease

    Directory of Open Access Journals (Sweden)

    R. Le Calloch

    2011-01-01

    Full Text Available Hodgkin's lymphoma is a disease with a high rate of curability under classic chemo-radiotherapy regimes. Complications due to chemotherapy could include viral reactivation due to chronic lymphopenia. BK virus (BKV is a polyoma virus belonging to the Papovaviridae family with antibody seroprevalences in healthy populations varying from 60% to 80%. Initial infections are asymptomatic usually occur in early childhood, after which the viruses remain latent in the kidneys or urothelium. Reactivation of BKV occurs in individuals with severe immunosuppression during HIV infections, transplantation or, exceptionally, after classical chemotherapy. BKV incidence is approximately 0% to 5% in immunocompetent individuals. Reactivation is associated with nephropathy and haemorrhagic cystitis. Herein, we present a case of a haemorrhagic cystitis due to BKV reactivation in a patient with Hodgkin's disease treated with chemotherapy.

  11. Simultaneous BK Polyomavirus (BKPyV)-associated nephropathy and hemorrhagic cystitis after living donor kidney transplantation.

    Science.gov (United States)

    Helanterä, Ilkka; Hirsch, Hans H; Wernli, Marion; Ortiz, Fernanda; Lempinen, Marko; Räisänen-Sokolowski, Anne; Auvinen, Eeva; Mannonen, Laura; Lautenschlager, Irmeli

    2016-03-01

    BK polyomavirus (BKPyV) commonly reactivates after kidney transplantation, and can cause polyomavirus-associated nephropathy (PyVAN), whereas after allogeneic stem cell transplantation the most frequent manifestation of BKPyV is polyomavirus-associated hemorrhagic cystitis (PyVHC). Despite high-level BKPyV replication in both, the pathogenesis and manifestation of both BKPyV entities appears to differ substantially. We describe an unusual case of simultaneous PyVAN and PyVHC presenting with acute symptoms in a BKPyV-IgG positive recipient eight months after kidney transplantation from a haploidentical living donor, who was BKPyV-IgG negative. Symptoms of cystitis and viremia subsided rapidly after reduction of immunosuppression. PMID:26771744

  12. Perspectivas futuras de tratamiento en la insuficiencia cardíaca: del trasplante de células a la regeneración cardíaca

    OpenAIRE

    Prosper, F.; Herreros, J.; J. Barba

    2004-01-01

    En los últimos años hemos asistido a un interés creciente por el tratamiento de la insuficiencia cardíaca mediante el trasplante de células madre. Mientras que los estudios con células madre de músculo (mioblastos) se iniciaron hace más de 10 años, la posibilidad de que las células madre de la médula ósea tengan un enorme potencial de diferenciación y proliferación ha estimulado la investigación con otros tipos de células madre. Estos estudios experimentales han demost...

  13. Las células T reguladoras y su influencia en la sobrevida del trasplante renal Regulatory T cells and their influence in kidney allograft survival

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    Sonia Y. Velásquez

    2007-10-01

    Full Text Available La respuesta inmune desencadenada frente a un trasplante alogénico conduce usualmente a una respuesta efectora que resulta en el rechazo del aloinjerto; sin embargo, algunos individuos mantienen un trasplante funcionante a largo plazo sin signos de rechazo (tolerancia operacional, aun en ausencia de inmunosupresión. Se ha sugerido que los mismos mecanismos son responsables para la tolerancia hacia antígenos propios y aloantígenos. Uno de estos mecanismos es la regulación inmune y se han identificado varias subpoblaciones de células con propiedades reguladoras. Entre ellas, la población celular mejor caracterizada corresponde a las células T reguladoras (Tregs. Aunque las Tregs en ratones son CD4+CD25+, en humanos el fenotipo de las Treg está restringida a las células T CD4 con alta expresión de CD25 (CD25high y del factor de transcripción Foxp3. El análisis fenotípico y funcional de las células T reguladoras o supresoras circulantes en pacientes trasplantados tal vez sea útil para la detección de pacientes tolerantes operacionales. Además, una futura manipulación in vitro de estas células con fines terapéuticos podría conducir a lograr la inducción de tolerancia in vivo en el trasplante clínico. Aquí, revisamos la evidencia experimental y clínica del papel de las células reguladoras en la biología del trasplante.The immune response elicited by an allogenic transplant usually leads to an effector response resulting in allograft rejection; however, some individuals maintain a long-term functioning transplant without signs of rejection (operational tolerance even in the absence of immunosuppression. It has been suggested that the same mechanisms are responsible for tolerance to self-antigens and alloantigens. One of such mechanisms is immune regulation and several cell subsets with regulatory properties have been identified. Among them, the best characterized cell populations are the regulatory T cells (Treg. Although

  14. Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway.

    Science.gov (United States)

    Che, Tongtong; Sun, Hui; Li, Jingxin; Yu, Xiao; Zhu, Dexiao; Xue, Bing; Liu, Kejing; Zhang, Min; Kunze, Wolfgang; Liu, Chuanyong

    2012-05-01

    Oxytocin (OT) is clinically important in gut motility and constitutively reduces duodenum contractility. Intrinsic primary afferent neurons (IPANs), whose physiological classification is as AH cells, are the 1st neurons of the peristaltic reflex pathway. We set out to investigate if this inhibitory effect is mediated by IPANs and to identify the ion channel(s) and intracellular signal transduction pathway that are involved in this effect. Myenteric neurons were isolated from the longitudinal muscle myenteric plexus (LMMP) preparation of rat duodenum and cultured for 16-24 h before electrophysiological recording in whole cell mode and AH cells identified by their electrophysiological characteristics. The cytoplasmic Ca²⁺ concentration ([Ca²⁺](i) ) of isolated neurons was measured using calcium imaging. The concentration of IP(3) in the LMMP and the OT secreted from the LMMP were measured using ELISA. The oxytocin receptor (OTR) and large-conductance calcium-activated potassium (BK(Ca)) channels, as well as the expression of OT and the IPAN marker calbindin 28 K, on the myenteric plexus neurons were localized using double-immunostaining techniques. We found that administration of OT (10⁻⁷ to 10⁻⁵ M) dose dependently hyperpolarized the resting membrane potential and increased the total outward current. The OTR antagonist atosiban or the BK(Ca) channel blocker iberiotoxin (IbTX) blocked the effects of OT suggesting that the increased outward current resulted from BK(Ca) channel opening. OTR and the BK(Ca) α subunit were co-expressed on a subset of myenteric neurons at the LMMP. NS1619 (10⁻⁵ M, a BK(Ca) channel activator) increased the outward current similar to the effect of OT. OT administration also increased [Ca²⁺](i) and the OT-evoked outward current was significantly attenuated by thapsigargin (10⁻⁶ M) or CdCl₂. The effect of OT on the BK(Ca) current was also blocked by pre-treatment with the IP₃ receptor antagonist 2-APB (10⁻⁴ M

  15. Source Material and Concentration of Wildfire-Produced Pyrogenic Carbon Influence Post-Fire Soil Nutrient Dynamics

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    Lucas A. Michelotti

    2015-04-01

    Full Text Available Pyrogenic carbon (PyC is produced by the thermal decomposition of organic matter in the absence of oxygen (O. PyC affects nutrient availability, may enhance post-fire nitrogen (N mineralization rates, and can be a significant carbon (C pool in fire-prone ecosystems. Our objectives were to characterize PyC produced by wildfires and examine the influence that contrasting types of PyC have on C and N mineralization rates. We determined C, N, O, and hydrogen (H concentrations and atomic ratios of charred bark (BK, charred pine cones (PC, and charred woody debris (WD using elemental analysis. We also incubated soil amended with BK, PC, and WD at two concentrations for 60 days to measure C and N mineralization rates. PC had greater H/C and O/C ratios than BK and WD, suggesting that PC may have a lesser aromatic component than BK and WD. C and N mineralization rates decreased with increasing PyC concentrations, and control samples produced more CO2 than soils amended with PyC. Soils with PC produced greater CO2 and had lower N mineralization rates than soils with BK or WD. These results demonstrate that PyC type and concentration have potential to impact nutrient dynamics and C flux to the atmosphere in post-fire forest soils.

  16. Viviendo con trasplante renal, sin protección social en salud: ¿Qué dicen los enfermos sobre las dificultades económicas que enfrentan y sus efectos?

    Directory of Open Access Journals (Sweden)

    Francisco Javier Mercado-Martínez

    2014-10-01

    Full Text Available El trasplante es el mejor tratamiento para la insuficiencia renal, de acuerdo con la biomedicina; sin embargo, es una tecnología cara. Este artículo examina las dificultades económicas y sus efectos en personas con trasplante renal, pero sin protección social en salud. Para el estudio se desarrolló una investigación cualitativa en México. Participaron 21 pacientes trasplantados; se aplicaron entrevistas semiestructuradas, y se realizó un análisis de contenido. Los resultados muestran que las personas enfermas enfrentan dificultades económicas, debido a los costes de las terapias renales, particularmente, de las medicinas. Todo ello tiene efectos negativos: las personas con pocos recursos dejan el tratamiento con medicamentos, abandonan el protocolo, no asisten a las consultas médicas y disminuyen los gastos domésticos, incluyendo el de alimentación; además de suponer una merma en los ingresos familiares. En conclusión, el trasplante renal empobrece a las personas enfermas sin protección social en salud; es urgente la implementación de un sistema de protección social para esta población.

  17. Hydrogen Peroxide Stimulates the Ca2+-activated Big-Conductance K Channels (BK) Through cGMP Signaling Pathway in Cultured Human Endothelial Cells

    OpenAIRE

    Dong, De-Li; Yue, Peng; Yang, Bao-Feng; Wang, Wen-Hui

    2008-01-01

    We used the whole cell patch-clamp technique to examine the effect of hydrogen peroxide (H2O2) on the Ca2+-activated BK channels in human endothelial cells. We confirmed the previous finding that a 200 pS BK channel activity was detected when the cell membrane potential was clamped at 50 mV. Application of H2O2 or adding glucose oxidase (GO) stimulated BK channels. The stimulatory effect of H2O2 and GO was absent in cells treated with ebselen, a scavenger of reactive oxygen species (ROS). To ...

  18. Cooperación jurídica internacional en materia de donación y trasplante de organos: hacia un nuevo paradigma

    Directory of Open Access Journals (Sweden)

    Joaquín Cayón de las CUEVAS

    2013-04-01

    Full Text Available RESUMEN El trasplante de órganos puede contribuir decisivamente no sólo a salvar vidas sino también a mejorar la calidad de las mismas. Sin embargo, el problema fundamental al que se enfrenta este tipo de terapias es la desproporción entre la oferta y la demanda. El número de donantes es, por definición, muy limitado y la donación puede no resultar posible por motivos diversos tales como la falta de autorización familiar o la ausencia de condiciones necesarias. Así las cosas, la dificultad en el acceso a las terapias de trasplante constituye el reflejo de una de las desigualdades en salud. Por otra parte, la escasez de órganos hace pervivir el indeseable fenómeno de la comercialización internacional. Resulta evidente que el problema de la insuficiencia de donantes afecta a toda la comunidad trasplantadora internacional dado que las necesidades de trasplantes son equivalentes en las diferentes regiones del mundo. En este sentido, el futuro pasa por propiciar una progresiva integración de las políticas públicas en materia de donación y trasplantes de órganos, superando el actual estadio de cooperación intergubernamental, loable pero insuficiente, para adentrarnos gradualmente en un nuevo paradigma de coordinación internacional de ámbito regional, condicionado a la previa armonización de la legislación de las naciones afectadas, que permita cifras homologables de donantes. Este nuevo paradigma de coordinación debe instrumentar mecanismos de prevención del fenómeno del turismo de trasplantes pero también facilitar y potenciar el intercambio internacional de órganos, removiendo desigualdades en el acceso al tratamiento trasplantador. RESUMO O transplante de órgãos pode ser valiosa não só para salvar vidas, mas também para melhorar a qualidade dos pacientes. No entanto, o problema fundamental dessas terapias é o desequilíbrio entre oferta e demanda. O número de doadores é muito limitado e a doação pode não ser

  19. A transição no transplante hepático: um estudo de caso La transición en el trasplante: un estudio de caso The transition in liver trasplantation: a case study

    Directory of Open Access Journals (Sweden)

    Liliana Andreia Neves da Mota

    2011-12-01

    Full Text Available Contexto: as transições de saúde/doença são uma dimensão importante da prática de enfermagem. É com a ajuda à pessoa na vivência de transições saudáveis que os enfermeiros podem ser verdadeiramente significativos. O doente transplantado hepático vive, durante o período pós-transplante, uma enorme necessidade de adaptação à nova condição. Objetivos:operacionalizar a teoria de Médio alcance de Meleis à vivência de uma transição saúde/doença de um doente numa situação de transplante hepático, em contexto de hepatite fulminante. Metodologia: estudo de caso operacionalizando a teoria de Médio alcance de Meleis a uma situação concreta. Neste sentido, foi efetuada uma análise aos registos eletrónicos de enfermagem, assim como uma entrevista semiestruturada ao doente selecionado por conveniência para o estudo de caso. Discussão: a teoria de médio alcance de Meleis é uma teoria exequível na área da transplantação hepática. Com base nesta teoria é possível implementar um processo de Enfermagem individualizado, uma vez que é possível precaver o sentido da transição do doente. Conclusão: é fundamental que os enfermeiros alicercem a sua prática na evidência, para que tenham práticas mais sustentadas.Contexto: las transiciones entre la salud y la enfermedad son una importante dimensión de la práctica de Enfermería. Es con la ayuda a la persona en la vivencia de transiciones saludables que los enfermeros pueden ser verdaderamente significativos. El paciente trasplantado hepático vive durante el postrasplante una enorme necesidad de adaptación a la nueva condición. Objetivos: aplicar la teoría de Medio alcance de Meleis a la vivencia de una transición salud/enfermedad de un paciente en una situación de trasplante hepático, en contexto de hepatitis fulminante. Metodología: se realizó un estudio de caso aplicando la teoría de Medio alcance de Meleis a una situación concreta. En este sentido, se

  20. Probing new physics through B->K l+ l- decays in R-parity violating minimal supersymmetric standard model

    CERN Document Server

    Mir, Azeem

    2009-01-01

    We study the decay rate of process B->K l+ l- (l=e,mu) and some of its other related observables, like forward backward asymmetry (A_{FB}), polarization asymmetry (PA) and CP-asymmetry (A_{CP}) in R-parity violating (R_{p}) Minimal Supersymmetric Standard Model (MSSM). The analysis shows that R_{p}Yukawa coupling products contribute significantly to the branching fraction of B->K l+ l- within 1 sigma and 2 sigma. Study shows that PA and A_{FB} are sensitive enough to R_{p}Yukawa coupling products and turn out to be good predictions for measurement in future experiments.The CP-asymmetry calculated in this framework agrees well with the recently reported value(i.e. 7%).

  1. Rapid detection and identification of JC virus and BK virus in human urine by using immunofluorescence microscopy.

    OpenAIRE

    Hogan, T. F.; Padgett, B L; Walker, D. L.; Borden, E C; McBain, J A

    1980-01-01

    An indirect immunofluorescence method was developed and used to detect urinary excretion of abnormal transitional cells infected with JC virus (JCV) or BK virus (BKV). This method was compared with urinary cytology, electron microscopy, viral culture, and viral serology in groups of immunosuppressed renal transplant recipients and normal controls. The indirect immunofluorescence method detected and identified JCV excretion in four persons, BKV excretion in one person, and both JCV and BKV exc...

  2. No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses

    OpenAIRE

    Groom, Harriet C. T.; Warren, Anne Y; David E Neal; Kate N Bishop

    2012-01-01

    The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in the patient samples. In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques. Despite demonstrating DNA integrity and assay sensitivity...

  3. Production and investigation of thin films of metal actinides (Pu, Am, Cm, Bk, Cf)

    Science.gov (United States)

    Radchenko, V. M.; Ryabinin, M. A.; Stupin, V. A.

    2010-03-01

    Under limited availability of transplutonium metals some special techniques and methods of their production have been developed that combine the process of metal reduction from a chemical compound and preparation of a sample for examination. In this situation the evaporation and condensation of metal onto a substrate becomes the only possible technology. Thin film samples of metallic 244Cm, 248Cm and 249Bk were produced by thermal reduction of oxides with thorium followed by deposition of the metals in the form of thin layers on tantalum substrates. For the production of 249Cf metal in the form of a thin layer the method of thermal reduction of oxide with lanthanum was used. 238Pu and 239Pu samples in the form of films were prepared by direct high temperature evaporation and condensation of the metal onto a substrate. For the production of 241Am films a gram sample of plutonium-241 metal was used containing about 18 % of americium at the time of production. Thermal decomposition of Pt5Am intermetallics in vacuum was used to produce americium metal with about 80% yield. Resistivity of the metallic 249Cf film samples was found to decrease exponentially with increasing temperature. The 249Cf metal demonstrated a tendency to form preferably a DHCP structure with the sample mass increasing. An effect of high specific activity on the crystal structure of 238Pu nuclide thin layers was studied either.

  4. Production and investigation of thin films of metal actinides (Pu, Am, Cm, Bk, Cf)

    International Nuclear Information System (INIS)

    Under limited availability of transplutonium metals some special techniques and methods of their production have been developed that combine the process of metal reduction from a chemical compound and preparation of a sample for examination. In this situation the evaporation and condensation of metal onto a substrate becomes the only possible technology. Thin film samples of metallic 244Cm, 248Cm and 249Bk were produced by thermal reduction of oxides with thorium followed by deposition of the metals in the form of thin layers on tantalum substrates. For the production of 249Cf metal in the form of a thin layer the method of thermal reduction of oxide with lanthanum was used. 238Pu and 239Pu samples in the form of films were prepared by direct high temperature evaporation and condensation of the metal onto a substrate. For the production of 241Am films a gram sample of plutonium-241 metal was used containing about 18 % of americium at the time of production. Thermal decomposition of Pt5Am intermetallics in vacuum was used to produce americium metal with about 80% yield. Resistivity of the metallic 249Cf film samples was found to decrease exponentially with increasing temperature. The 249Cf metal demonstrated a tendency to form preferably a DHCP structure with the sample mass increasing. An effect of high specific activity on the crystal structure of 238Pu nuclide thin layers was studied either.

  5. The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Hongkyun Kim

    2009-12-01

    Full Text Available Genetic defects in the dystrophin-associated protein complex (DAPC are responsible for a variety of pathological conditions including muscular dystrophy, cardiomyopathy, and vasospasm. Conserved DAPC components from humans to Caenorhabditis elegans suggest a similar molecular function. C. elegans DAPC mutants exhibit a unique locomotory deficit resulting from prolonged muscle excitation and contraction. Here we show that the C. elegans DAPC is essential for proper localization of SLO-1, the large conductance, voltage-, and calcium-dependent potassium (BK channel, which conducts a major outward rectifying current in muscle under the normal physiological condition. Through analysis of mutants with the same phenotype as the DAPC mutants, we identified the novel islo-1 gene that encodes a protein with two predicted transmembrane domains. We demonstrate that ISLO-1 acts as a novel adapter molecule that links the DAPC to SLO-1 in muscle. We show that a defect in either the DAPC or ISLO-1 disrupts normal SLO-1 localization in muscle. Consistent with observations that SLO-1 requires a high calcium concentration for full activation, we find that SLO-1 is localized near L-type calcium channels in muscle, thereby providing a mechanism coupling calcium influx with the outward rectifying current. Our results indicate that the DAPC modulates muscle excitability by localizing the SLO-1 channel to calcium-rich regions of C. elegans muscle.

  6. P-waves imaging of the FRI and BK zones at the Grimsel Rock Laboratory

    International Nuclear Information System (INIS)

    This report is one of a series documenting the results of the Nagra-DOE Cooperative (NDC-I) research program in which the cooperating scientists explore the geological, geophysical, hydrological, geochemical, and structural effects anticipated from the use of a rock mass as a geological repository for nuclear waste. Tomographic imaging studies using a high frequency (10 Khz.) piezoelectric source and a three component receiver were carried out in two different regions of the underground Nagra Grimsel test facility in Switzerland. Both sites were in fractured granite, one being in a strongly foliated granite (FRI site), and the other being in a relatively homogeneous granite (BK zone). The object of the work was to determine if the seismic techniques could be useful in imaging the fracture zones and provide information on the hydrologic conditions. Both amplitude and velocity tomograms were obtained from the Data. The results indicate that the fracture zones strongly influenced the seismic wave propagation, thus imaging the fracture zones that were hydrologically important. 11 refs., 24 figs

  7. Human BK Polyomavirus—The Potential for Head and Neck Malignancy and Disease

    Directory of Open Access Journals (Sweden)

    Raquel Burger-Calderon

    2015-07-01

    Full Text Available Members of the human Polyomaviridae family are ubiquitous and pathogenic among immune-compromised individuals. While only Merkel cell polyomavirus (MCPyV has conclusively been linked to human cancer, all members of the polyomavirus (PyV family encode the oncoprotein T antigen and may be potentially carcinogenic. Studies focusing on PyV pathogenesis in humans have become more abundant as the number of PyV family members and the list of associated diseases has expanded. BK polyomavirus (BKPyV in particular has emerged as a new opportunistic pathogen among HIV positive individuals, carrying harmful implications. Increasing evidence links BKPyV to HIV-associated salivary gland disease (HIVSGD. HIVSGD is associated with elevated risk of lymphoma formation and its prevalence has increased among HIV/AIDS patients. Determining the relationship between BKPyV, disease and tumorigenesis among immunosuppressed individuals is necessary and will allow for expanding effective anti-viral treatment and prevention options in the future.

  8. Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma?

    Directory of Open Access Journals (Sweden)

    Dorota Polz

    2015-02-01

    Full Text Available Introduction. Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90% of all head and neck cancers are represented by squamous cell carcinoma (SCC. There are many risk factors causing this type of cancer, including environmental factors and lifestyle choices, such as tobacco smoking or abusing alcohol. Other important risk factor include infectious factors. [b]Objective[/b]. The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC. [b]Materials and method[/b]. The correlation between BKV infection and OSCC, and correlation between BKV, OSCC, alcohol abuse, tobacco smoking, demographic data, pre-treatment staging, metastases of lymph node evidence, and grading, was analyzed. The study group consisted of 92 patients with squamous cell carcinoma (OSCC, 75 males, and 17 females, aged between 40 – 87 (average 56.8. All the patients underwent surgery and were not subjected to chemotherapy or radiotherapy prior to treatment. The analyzed samples were collected from paraffin sections. [b]Results[/b]. BKV DNA was detected in 18.5% of patients with OSCC. In the control group, BKV DNA was detected in 3.3%. BKV DNA was statistically more frequently detected among patients with squamous carcinoma, compared to the control group (p<0.05. [b]Conclusions[/b]. The obtained results suggest that the BKV virus may play an important role in the development of oral squamous cell carcinoma.

  9. UV protection filters by dielectric multilayer thin films on Glass BK-7 and Infrasil 301

    Science.gov (United States)

    Abdel-Aziz, M. M.; Azim, Osama A.; Abdel-Wahab, L. A.; Seddik, Mohamed M.

    2006-10-01

    The increasing use of Ultraviolet (UV) light in medicine, industrial environments, for cosmetic use, and even in consumer products necessitates that greater attention be paid to the potential hazards of this type of electromagnetic radiation. To avoid any adverse effects of exposure to this type of radiation, four suitable protection filters were produced to block three UV bands (UVA, UVB, and UVC). The design structure of the required dielectric multilayer filters was done by optical thin film technology using the absorbing property of UV radiation for the substrates and dielectric materials. The computer analyses of the multilayer filter formulas were prepared using Macleod Software for the production processes. The deposition technique was achieved on optical substrates (Glass BK-7 and Infrasil 301) by dielectric material combinations including Titanium dioxide (Ti 2O 3), Hafnium dioxide (HfO 2), and Lima (mixture of oxides SiO 2/Al 2O 3); deposition being achieved using an electron beam gun. The output results of the theoretical and experimental transmittance values for spectral band from 200 nm to 800 nm were discussed in four processes. To analyze the suitability for use in 'real world' applications, the test pieces were subjected to the durability tests (adhesion, abrasion resistance, and humidity) according to Military Standard MIL-C-675C and MIL-C-48497A.

  10. UV protection filters by dielectric multilayer thin films on Glass BK-7 and Infrasil 301

    International Nuclear Information System (INIS)

    The increasing use of Ultraviolet (UV) light in medicine, industrial environments, for cosmetic use, and even in consumer products necessitates that greater attention be paid to the potential hazards of this type of electromagnetic radiation. To avoid any adverse effects of exposure to this type of radiation, four suitable protection filters were produced to block three UV bands (UVA, UVB, and UVC). The design structure of the required dielectric multilayer filters was done by optical thin film technology using the absorbing property of UV radiation for the substrates and dielectric materials. The computer analyses of the multilayer filter formulas were prepared using Macleod Software for the production processes. The deposition technique was achieved on optical substrates (Glass BK-7 and Infrasil 301) by dielectric material combinations including Titanium dioxide (Ti2O3), Hafnium dioxide (HfO2), and Lima (mixture of oxides SiO2/Al2O3); deposition being achieved using an electron beam gun. The output results of the theoretical and experimental transmittance values for spectral band from 200 nm to 800 nm were discussed in four processes. To analyze the suitability for use in 'real world' applications, the test pieces were subjected to the durability tests (adhesion, abrasion resistance, and humidity) according to Military Standard MIL-C-675C and MIL-C-48497A

  11. Interaction Between Human Polyomavirus BK and Hypoxia Inducible Factor-1 alpha.

    Science.gov (United States)

    Signorini, Lucia; Croci, Mattia; Boldorini, Renzo; Varella, Rafael Brandao; Elia, Francesca; Carluccio, Silvia; Villani, Sonia; Bella, Ramona; Ferrante, Pasquale; Delbue, Serena

    2016-06-01

    BK polyomavirus (BKV) has a worldwide seroprevalence of approximately 90%. After primary infection, BKV establishes a life-long latency within the urogenital tract. The severe immunological impairment occurring in renal transplant recipients leads to BKV reactivation, which may result in polyomavirus associated nephropathy (PVAN). While the transplanted kidney is transiently unperfused, Hypoxia Inducible Factors (HIFs) mediate the cellular response to hypoxia. The α-subunit of HIF isoform 1 (HIF-1α) may interact with several viruses, but until now, there has been no information regarding the interaction between BKV and HIF-1α. The aim of this study is to investigate the possible interaction between HIF-1α and BKV and its potential effect on the pathogenesis of PVAN. Screening of 17 kidney tissue samples revealed that HIF-1α expression was 13.6-fold higher in PVAN tissues compared to control tissues. A luminometric assay in co-transfected African green monkey kidney cells (VERO) demonstrated BKV promoter activation ranging from two to sixfold (P hypoxia, compared to the cells not subjected to hypoxia. Both ex vivo and in vitro interactions between HIF-1α and BKV were observed, suggesting that HIF-1α, stabilized during transplantation, may be able to bind the BKV promoter and enhance BKV replication. Thus, hypoxia should be considered a risk factor for the development of PVAN in kidney transplant recipients. J. Cell. Physiol. 231: 1343-1349, 2016. © 2015 Wiley Periodicals, Inc. PMID:26529465

  12. Continuum Limit of $B_K$ from 2+1 Flavor Domain Wall QCD

    CERN Document Server

    Aoki, Y; Blum, T; Boyle, P A; Brömmel, D; Christ, N H; Dawson, C; Izubuchi, T; Jung, C; Kelly, C; Kenway, R D; Lightman, M; Mawhinney, R D; Ohta, Shigemi; Sachrajda, C T; Scholz, E E; Soni, A; Sturm, C; Wennekers, J; Zhou, R

    2010-01-01

    We determine the neutral kaon mixing matrix element $B_K$ in the continuum limit with 2+1 flavors of domain wall fermions, using the Iwasaki gauge action at two different lattice spacings. These lattice fermions have near exact chiral symmetry and therefore avoid artificial lattice operator mixing. We introduce a significant improvement to the conventional NPR method in which the bare matrix elements are renormalized non-perturbatively in the RI-MOM scheme and are then converted into the MSbar scheme using continuum perturbation theory. In addition to RI-MOM, we introduce and implement four non-exceptional intermediate momentum schemes that suppress infrared non-perturbative uncertainties in the renormalization procedure. We compute the conversion factors relating the matrix elements in this family of RI-SMOM schemes and MSbar at one-loop order. Comparison of the results obtained using these different intermediate schemes allows for a more reliable estimate of the unknown higher-order contributions and hence ...

  13. UV protection filters by dielectric multilayer thin films on Glass BK-7 and Infrasil 301

    Energy Technology Data Exchange (ETDEWEB)

    Abdel-Aziz, M.M. [Physics Department, Faculty of Education, Ain Shams University, Cairo 11566 (Egypt)]. E-mail: melaziz@link.net; Azim, Osama A. [Vacuum Coating Manager, Arab International Optronics Co., El-salam City, Cairo 11566 (Egypt); Abdel-Wahab, L.A. [Head of Thermal Analysis Lab, National Center for Radiation Research and Technology, Cairo 11566 (Egypt); Seddik, Mohamed M. [Engineering Physics Department, Faculty of Engineering, Ain Shams University, Cairo 11566 (Egypt)

    2006-10-15

    The increasing use of Ultraviolet (UV) light in medicine, industrial environments, for cosmetic use, and even in consumer products necessitates that greater attention be paid to the potential hazards of this type of electromagnetic radiation. To avoid any adverse effects of exposure to this type of radiation, four suitable protection filters were produced to block three UV bands (UVA, UVB, and UVC). The design structure of the required dielectric multilayer filters was done by optical thin film technology using the absorbing property of UV radiation for the substrates and dielectric materials. The computer analyses of the multilayer filter formulas were prepared using Macleod Software for the production processes. The deposition technique was achieved on optical substrates (Glass BK-7 and Infrasil 301) by dielectric material combinations including Titanium dioxide (Ti{sub 2}O{sub 3}), Hafnium dioxide (HfO{sub 2}), and Lima (mixture of oxides SiO{sub 2}/Al{sub 2}O{sub 3}); deposition being achieved using an electron beam gun. The output results of the theoretical and experimental transmittance values for spectral band from 200 nm to 800 nm were discussed in four processes. To analyze the suitability for use in 'real world' applications, the test pieces were subjected to the durability tests (adhesion, abrasion resistance, and humidity) according to Military Standard MIL-C-675C and MIL-C-48497A.

  14. Determining the Solar Inactivation Rate of BK Polyomavirus by Molecular Beacon.

    Science.gov (United States)

    Reano, Dane C; Yates, Marylynn V

    2016-07-01

    The application of molecular beacons (MB) that bind to precise sequences of mRNA provides a near-universal approach in detecting evidence of viral replication. Here, we demonstrate the detection of BK Polyomavirus (BKPyV), an emerging indicator of microbiological water quality, by a quantum dot-based MB. The MB allowed us to rapidly characterize the inactivation rate of BKPyV following exposure to a solar simulator (kobs = 0.578 ± 0.024 h(-1), R(2) = 0.92). Results were validated through a traditional cell-culture assay with immunofluorescence detection (kobs = 0.568 ± 0.011 h(-1), R(2) = 0.97), which exhibited a strong correlation to MB data (R(2) = 0.93). Obtaining solar inactivation rates for BKPyV demonstrates the first use of a MB in characterizing a microbiological inactivation profile and helps assess the appropriateness of adopting BKPyV as an indicator organism for water quality. PMID:27269231

  15. Trasplante pulmonar: Evolución y complicaciones. Experiencia de Clínica Las Condes LUNG TRANSPLANTATION: EVOLUTION AND COMPLICATIONS. CLINICAL EXPERIENCE

    Directory of Open Access Journals (Sweden)

    M. TERESA PARADA C

    2003-04-01

    Full Text Available El trasplante pulmonar es una alternativa terapéutica para pacientes con enfermedad pulmonar severa sin respuesta a tratamiento. Objetivos: Evaluar los resultados y complicaciones de los pacientes trasplantados en Clínica Las Condes. Material y método: 21 pacientes trasplantados entre abril 1999 a mayo de 2003: 10 trasplantes simples y 11 bipulmonares, edad x 48 años (13-70;13 hombres; patología predominante fibrosis pulmonar idiopática: 10 (48%. Espirometría basal en patología restrictiva CVF: x 1.827 ml (43 % (1.170 - 2.430 ml y obstructiva: VEF1 x 818 ml (24% (352 - 1.756 ml, todos dependientes de oxígeno. Inmunosupresión triasociada: prednisona, azatioprina y ciclosporina o tacrolimus. Resultados: 3 pacientes fallecen a los 30 días por hemorragia cerebral, hemoptisis masiva y sepsis respectivamente. Seguimiento de 2 a 45 meses. Evolución espirométrica (VEF1: 1 año 2.107 ml (67% , 2 años 2.012 ml (65% y 3 años 2.440 ml (74%. Todos suspenden oxígeno y realizan actividad física. Complicaciones: Disfunción primaria de injerto 2, rechazo agudo 4, lesión vía aérea 2, neumonia por Citomegalovirus 2, síndrome de bronquiolitis obliterante (SBO 3 y fallecen dos. Conclusiones: El trasplante pulmonar mejora calidad de vida en pacientes con enfermedad pulmonar terminal y nuestros resultados confirman que es una alternativa posible en nuestro paísBackground: Lung transplantation is a valid treatment for some patients with severe lung disease who have a poor prognosis with medical treatment. Objective: to evaluate the results and complications of lung transplantation in a series of patients at Clinica Las Condes. Patients and methods: 21 lung transplanted patients from April 1999 to May 2003; 10 single and 11 bilateral; mean age 48 years, range 13 to 70 years; 13 men (62%. The most frequent diagnosis was idiopathic pulmonary fibrosis (10 patients; 48%. Mean FVC for restrictive disorders was 1 827 ml (43% predicted and mean FEV1 for

  16. The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion

    Directory of Open Access Journals (Sweden)

    Helander Herbert F

    2003-02-01

    Full Text Available Abstract Background This study investigates bradykinin and nitric oxide as potential mediators of AT2-receptor-stimulated duodenal mucosal alkaline secretion. Duodenal mucosal alkaline secretion was measured in methohexital- and α-chloralose-anaesthetised rats by means of in situ pH-stat titration. Immunohistochemistry and Western blot were used to identify the BK2 receptors. Results The AT2 receptor agonist CGP42112A (0.1 μg kg-1 min-1 administered intravenously increased the duodenal mucosal alkaline secretion by ~50 %. This increase was sensitive to the selective BK2 receptor blocker HOE140 (100 ng/kg iv, but not to luminal administration of the NOS blocker L-NAME (0.3 mM. Mean arterial pressure did not differ between groups during the procedures. Immunohistochemistry showed a distinct staining of the crypt epithelium and a moderate staining of basal cytoplasm in villus enterocytes. Conclusion The results suggest that the AT2-receptor-stimulated alkaline secretion is mediated via BK2 receptors located in the duodenal cryptal mucosal epithelium.

  17. Renovascular BK(Ca) channels are not activated in vivo under resting conditions and during agonist stimulation

    DEFF Research Database (Denmark)

    Magnusson, Linda; Sørensen, Charlotte Mehlin; Braunstein, Thomas Hartig;

    2006-01-01

    of renal vascular BK(Ca) channels by cAMP was investigated by infusing forskolin. Renal blood flow (RBF) was measured in vivo using electromagnetic flowmetry or ultrasonic Doppler. Renal preinfusion of tetraethylammonium (TEA; 3.0 mumol/min) caused a small reduction of baseline RBF, but iberiotoxin...... (IBT; 0.3 nmol/min) did not have any effect. Renal injection of ANG II (1-4 ng) or NE (10-40 ng) produced a transient decrease in RBF. These responses were not affected by preinfusion of TEA or IBT. Renal infusion of the BK(Ca) opener NS-1619 (90.0 nmol/min) did not affect basal RBF or the response to...... NE, but it attenuated the response to ANG II. Coadministration of NS-1619 with TEA or IBT abolished this effect. Forskolin caused renal vasodilation that was not inhibited by IBT. The presence of BK(Ca) channels in the preglomerular vessels was confirmed by immunohistochemistry. Despite their...

  18. Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion

    DEFF Research Database (Denmark)

    Wulf-Johansson, Helle; Hay-Schmidt, Anders; Poulsen, Asser Nyander;

    2009-01-01

    Large conductance calcium-activated potassium (BK(Ca)) channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release. Migraine has been proposed to be a trigeminovascular disease involving the sensory trigeminal pathways and the c......Large conductance calcium-activated potassium (BK(Ca)) channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release. Migraine has been proposed to be a trigeminovascular disease involving the sensory trigeminal pathways...

  19. Monitorización y efectos secundarios de los inmunosupresores en el trasplante Monitoring and secondary effects of immunosuppressants in the transplant

    Directory of Open Access Journals (Sweden)

    B. Sádaba

    2006-08-01

    Full Text Available El éxito del trasplante de órganos y su consideración como un tratamiento claramente establecido en algunas indicaciones se debe al desarrollo de fármacos inmunosupresores. Aunque no fue el primero de los fármacos utilizados, la introducción de la ciclosporina en los años 80 en el tratamiento inmunosupresor permitió el incremento del número de trasplantes y el éxito de esta práctica. Desde ese momento, la inmunosupresión se ha basado en la utilización de una combinación de fármacos, inicialmente ciclosporina, corticoides y azatioprina. En los últimos años se han introducido nuevos fármacos que han abierto las posibilidades de tratamiento. Pero todavía quedan algunas cuestiones pendientes, debido a la toxicidad asociada a su uso y a la posibilidad de interacciones con otros fármacos, lo cual complica su manejo y puede comprometer el pronóstico de estos enfermos. Inhibidores de la calcineurina y de la mTOR son los fármacos implicados con mayor frecuencia en interacciones con otros fármacos, lo cual obliga a anticiparse a esta posibilidad cuando se cambia la medicación concomitante.The success of organ transplants and their consideration as a clearly established treatment in some indications is due to the development of immunosuppressant drugs. While it was not the first of the drugs to be employed, the introduction of cyclosporin in the 1980s in immunosuppressant treatment made possible an increase in the number of transplants and the success of this practice. From then onwards, immunosuppression has been based on the use of a combination of drugs, initially cyclosporin, corticoids and azathioprine. In recent years new drugs have been introduced that have opened up the possibilities of treatment. But many pending questions remain, due to the toxicity associated with their use and the possibility of interaction with other drugs, which complicates their use and can compromise the prognoses of these patients. Calcineurin

  20. Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain.

    Science.gov (United States)

    Bukiya, Anna N; Patil, Shivaputra A; Li, Wei; Miller, Duane D; Dopico, Alex M

    2012-10-01

    Large conductance, calcium- and voltage-gated potassium (BK) channels regulate various physiological processes and represent an attractive target for drug discovery. Numerous BK channel activators are available. However, these agents usually interact with the ubiquitously distributed channel-forming subunit and thus cannot selectively target a particular tissue. We performed a structure-activity relationship study of lithocholic acid (LCA), a cholane that activates BK channels via the accessory BK β1 subunit. The latter protein is highly abundant in smooth muscle but scarce in most other tissues. Modifications to the LCA lateral chain length and functional group yielded two novel smooth muscle BK channel activators in which the substituent at C24 has a small volume and a net negative charge. Our data provide detailed structural information that will be useful to advance a pharmacophore in search of β1 subunit-selective BK channel activators. These compounds are expected to evoke smooth muscle relaxation, which would be beneficial in the pharmacotherapy of prevalent human disorders associated with increased smooth muscle contraction, such as systemic hypertension, cerebral or coronary vasospasm, bronchial asthma, bladder hyperactivity, and erectile dysfunction. PMID:22945504

  1. Actualización en trasplante de células progenitoras hematopoyéticas en pacientes pediátricos en los últimos 15 años Updating in transplant of hematopoietic progenitor cells in pediatric patients during the past 15 years

    OpenAIRE

    Elvira Dorticós-Balea; Juan C. Jaime-Fagundo; Valia Pavón-Morán; Mercedes Reboredo-Domínguez; Porfirio Hernández-Ramírez

    2011-01-01

    En el pasado año 2010 se conmemoró el 25º aniversario de la introducción en Cuba del trasplante de médula ósea, y su desarrollo ha seguido la secuencia de la historia universal del trasplante hematopoyético. En este trabajo nos referimos a los logros más importantes que se han alcanzado en los últimos 15 años, como ha sido la introducción del trasplante con células movilizadas hacia la sangre periférica. Se exponen los resultados parciales de un estudio comparativo de 2 grupos de pacientes pe...

  2. Continuum limit of Bk from 2+1 flavor domain wall QCD

    International Nuclear Information System (INIS)

    We determine the neutral kaon mixing matrix element BK in the continuum limit with 2+1 flavors of domain wall fermions, using the Iwasaki gauge action at two different lattice spacings. These lattice fermions have near exact chiral symmetry and therefore avoid artificial lattice operator mixing. We introduce a significant improvement to the conventional nonperturbative renormalization (NPR) method in which the bare matrix elements are renormalized nonperturbatively in the regularization invariant momentum scheme (RI-MOM) and are then converted into the MS- scheme using continuum perturbation theory. In addition to RI-MOM, we introduce and implement four nonexceptional intermediate momentum schemes that suppress infrared nonperturbative uncertainties in the renormalization procedure. We compute the conversion factors relating the matrix elements in this family of regularization invariant symmetric momentum schemes (RI-SMOM) and MS- at one-loop order. Comparison of the results obtained using these different intermediate schemes allows for a more reliable estimate of the unknown higher-order contributions and hence for a correspondingly more robust estimate of the systematic error. We also apply a recently proposed approach in which twisted boundary conditions are used to control the Symanzik expansion for off-shell vertex functions leading to a better control of the renormalization in the continuum limit. We control chiral extrapolation errors by considering both the next-to-leading order SU(2) chiral effective theory, and an analytic mass expansion. We obtain BKMS- (3 GeV) = 0.529(5)stat(15)χ(2)FV(11)NPR. This corresponds to B-KRGI- = 0.749(7)stat(21)χ(3)FV(15)NPR. Adding all sources of error in quadrature, we obtain B-KRGI- = 0.749(27)combined, with an overall combined error of 3.6%.

  3. Analysis of real-time mixture cytotoxicity data following repeated exposure using BK/TD models.

    Science.gov (United States)

    Teng, S; Tebby, C; Barcellini-Couget, S; De Sousa, G; Brochot, C; Rahmani, R; Pery, A R R

    2016-08-15

    Cosmetic products generally consist of multiple ingredients. Thus, cosmetic risk assessment has to deal with mixture toxicity on a long-term scale which means it has to be assessed in the context of repeated exposure. Given that animal testing has been banned for cosmetics risk assessment, in vitro assays allowing long-term repeated exposure and adapted for in vitro - in vivo extrapolation need to be developed. However, most in vitro tests only assess short-term effects and consider static endpoints which hinder extrapolation to realistic human exposure scenarios where concentration in target organs is varies over time. Thanks to impedance metrics, real-time cell viability monitoring for repeated exposure has become possible. We recently constructed biokinetic/toxicodynamic models (BK/TD) to analyze such data (Teng et al., 2015) for three hepatotoxic cosmetic ingredients: coumarin, isoeugenol and benzophenone-2. In the present study, we aim to apply these models to analyze the dynamics of mixture impedance data using the concepts of concentration addition and independent action. Metabolic interactions between the mixture components were investigated, characterized and implemented in the models, as they impacted the actual cellular exposure. Indeed, cellular metabolism following mixture exposure induced a quick disappearance of the compounds from the exposure system. We showed that isoeugenol substantially decreased the metabolism of benzophenone-2, reducing the disappearance of this compound and enhancing its in vitro toxicity. Apart from this metabolic interaction, no mixtures showed any interaction, and all binary mixtures were successfully modeled by at least one model based on exposure to the individual compounds. PMID:27317371

  4. Pérdida de glutatión desde pulmones de conejo en solución de preservación para trasplante: Efectos clínicos y funcionales a corto plazo Loss of glutathione from rabbit lungs in transplant preservation solution

    OpenAIRE

    MARíA E SOLOVERA R; JUAN E CHEYRE F; ANDREA VECCHIOLA C; PILAR CELIS L; PABLO SANDOVAL A; GISELLA BORZONE T

    2009-01-01

    El daño por isquemia-reperfusión es causa de morbimortalidad en pacientes con trasplante pulmonar. Se desconoce si la solución de preservación habitual del pulmón puede contribuir a la deficiencia de antioxidantes, favoreciendo el estrés oxidativo en el receptor. Objetivo: Evaluar si existe pérdida de glutatión desde pulmones de conejo a la solución de preservación para trasplante. Resultados: Encontramos una disminución en el contenido de glutatión total del pulmón, sin aumento en el conteni...

  5. Segunda fase de la aplicación de protocolo de cuidado oral para prevenir y/ o tratar la mucositis en pacientes sometidos a trasplante de precursores hematopoyéticos en la fundación hospital de la misericordia

    OpenAIRE

    Salazar Solis, Glendy; Barrios, Eblyn Hayek

    2012-01-01

    El trasplante de precursores hematopoyéticos es una alternativa de tratamiento para distintas condiciones en la población pediátrica y requiere un régimen quimioterapéutico con posibles complicaciones como la mucositis oral. Objetivo: Determinar la aparición de mucositis oral en los pacientes ingresados a la Unidad de Trasplante de Precursores Hematopoyéticos de la Fundación Hospital de la Misericordia y relacionarla con el índice de placa, el conteo de leucocitos y el tipo ...

  6. Costo-utilidad del trasplante renal frente a la hemodiálisis en el tratamiento de la insuficiencia renal crónica terminal en un hospital peruano Cost utility of renal transplant vs. hemodialysis in the treatment of end stage chronic kidney failure in a peruvian hospital

    Directory of Open Access Journals (Sweden)

    Ricardo E. Loza-Concha

    2011-09-01

    Full Text Available Objetivos. Determinar y comparar las razones de costo-utilidad de los trasplantes renales con donante cadavérico (TRDC practicados en el Hospital Nacional Guillermo Almenara Irigoyen los años 2000-2001, frente a hemodiálisis (HD, cinco años después del inicio del tratamiento. Material y métodos. Se realizó un estudio de costo utilidad, estudiando a todos los pacientes continuadores cinco años post TRDC, a quienes se asignó como controles, dos pacientes con cinco años de HD pareados por edad, sexo y tiempo de enfermedad. Se evaluaron los costos de cada procedimiento, los años de vida ajustados a la calidad (AVAC utilizando el cuestionario SF-36v2TM y se calcularon las razones de costo utilidad (CU y costo utilidad incremental (CUI. Resultados. Se realizaron 58 TRDC los años 2000-2001. Cinco años después, 17 (29 % pacientes fallecieron y 27 (47 % continuaron con su tratamiento post-TRDC. Treinta y uno (53 % TRDC fracasaron; 26 % por rechazo al trasplante, 55 % por complicación y 19 % por tratamiento irregular. Los puntajes SF-36v2TM promedio obtenidos por los TRDC y HD fueron 95±13 y 87±18 puntos respectivamente. En ambos años, los AVAC obtenidos por los TRDC y HD fueron de 251 y 229 puntos respectivamente; las razones de CU para los TRDC y los HD fueron de USD 11 984 y USD 9243, y la razón de CUI fue de USD 40 669. Conclusiones. Los TRDC realizados los años 2000-2001, cinco años después resultaron menos costo útiles que las HD; y los TRDC realizados el 2000 tuvieron una menor razón de costo utilidad incremental que los efectuados el 2001, probablemente por su mayor razón de tratamientos irregulares.Objectives. To assess and compare the cost utility of the cadaveric donor renal transplant (CDRT at the Hospital Nacional Guillermo Almenara Irigoyen between 2000 to 2001, against haemodialysis (HD, 5 years after treatment initiation. Materials and Methods. A cost utility study design was used, which evaluated every patient

  7. Energy up-conversion and trapping: Dynamics of 5f states of Bk4+ in CeF4

    International Nuclear Information System (INIS)

    Energy transfer mechanisms of excited 5f states of Bk4+ (0.05 atom %) in CeF4 containing circa 0.95 atom % Cf4+ have been investigated at 4 K. The observed anti-Stokes fluorescence arises from both up-conversion and two-photon excitation. Nonexponential decays of Stokes fluorescence are ascribed to both excitation-excitation annihilation and site-dependent trapping processes and, therefore, are not describable by the Inokuti-Hirayama or exciton annihilation models. Based on the Forster-Dexter energy transfer theory, a new model is developed to fit the observed fluorescence decay data. 16 refs., 3 figs

  8. Isospin Symmetry Breaking in B->K^* \\gamma Decay due to an Extra Generation of Vector Quarks

    CERN Document Server

    Ahmady, M R; Ahmady, Mohammad R.; Chishtie, Farrukh

    2005-01-01

    The extra contributions due to an extra generation of vector-like quarks to the isospin symmetry breaking observable associated with the radiative B->K^* \\gamma decay is obtained. It is shown that this additional contribution is sensitive to the nonunitarity parameter U^{sb}, which is a measure of the the strength of the non-zero tree-level flavor changing neutral current in this model. The significance of this result is that, once accurate experimental resultson the isospin asymmetry becomes available, one can constrain the U^{sb} independent of the mass of the extra quarks and so a much more stringent acceptablemodel parameter space could be obtained.

  9. Non-perturbative Renormalization of Four-Fermion Operators Relevant to $B_K$ with Staggered Quarks

    CERN Document Server

    Jeong, Hwancheol; Kim, Jongjeong; Lee, Weonjong; Pak, Jeonghwan; Park, Sungwoo

    2014-01-01

    We present preliminary results of matching factors of the four-fermion operators relevant to $B_K$, which are obtained using the non-perturbative renormalization (NPR) method in the RI-MOM scheme with HYP-smeared improved staggered fermions. We use the MILC asqtad coarse ($a \\cong 0.12\\,$fm) ensembles with $20^3 \\times 64$ geometry and $am_{\\ell}/am_s = 0.01/0.05$. We compare NPR results with those of one-loop perturbative matching.

  10. Early monitoring of the human polyomavirus BK replication and sequencing analysis in a cohort of adult kidney transplant patients treated with basiliximab

    Directory of Open Access Journals (Sweden)

    Mischitelli Monica

    2011-08-01

    Full Text Available Abstract Background Nowadays, better immunosuppressors have decreased the rates of acute rejection in kidney transplantation, but have also led to the emergence of BKV-associated nephropathy (BKVAN. Therefore, we prospectively investigated BKV load in plasma and urine samples in a cohort of kidney transplants, receiving basiliximab combined with a mycophenolate mofetil-based triple immunotherapy, to evaluate the difference between BKV replication during the first 3 months post-transplantation, characterized by the non-depleting action of basiliximab, versus the second 3 months, in which the maintenance therapy acts alone. We also performed sequencing analysis to assess whether a particular BKV subtype/subgroup or transcriptional control region (TCR variants were present. Methods We monitored BK viruria and viremia by quantitative polymerase chain reaction (Q-PCR at 12 hours (Tx, 1 (T1, 3 (T2 and 6 (T3 months post-transplantation among 60 kidney transplant patients. Sequencing analysis was performed by nested-PCR with specific primers for TCR and VP1 regions. Data were statistically analyzed using χ2 test and Student's t-test. Results BKV was detected at Tx in 4/60 urine and in 16/60 plasma, with median viral loads of 3,70 log GEq/mL and 3,79 log GEq/mL, respectively, followed by a significant increase of both BKV-positive transplants (32/60 and median values of viruria (5,78 log GEq/mL and viremia (4,52 log GEq/mL at T2. Conversely, a significantly decrease of patients with viruria and viremia (17/60 was observed at T3, together with a reduction of the median urinary and plasma viral loads (4,09 log GEq/mL and 4,00 log GEq/mL, respectively. BKV TCR sequence analysis always showed the presence of archetypal sequences, with a few single-nucleotide substitutions and one nucleotide insertion that, interestingly, were all representative of the particular subtypes/subgroups we identified by VP1 sequencing analysis: I/b-2 and IV/c-2. Conclusions Our

  11. Disfunción hepática en el trasplante de células progenitoras hematopoyéticas. Impacto sobre la mortalidad Liver dysfunction in recipients of hematopoietic stem cells. Impact on mortality

    OpenAIRE

    Daniel Cocozzella; Celina Méndez; Juliana Malacalza; Raúl Adrover; Silvia Borzi; Silvia Saba; Carlos Canepa; Emilio Fraquelli; José Curciarello

    2005-01-01

    El compromiso hepático en receptores de trasplante alogénico de células progenitoras hematopoyéticas (TCPH) es una complicación muy frecuente y es responsable de la morbimortalidad precoz. La toxicidad por fármacos, la enfermedad injerto versus huésped (EICH), la enfermedad venooclusiva (EVO) y las infecciones fúngicas, bacterianas y virales constituyen las principales etiologías. El objetivo de este estudio retrospectivo fue establecer la prevalencia y etiología de la afectación hepática, ev...

  12. Reconstrucción total y parcial de cejas con trasplante de unidades foliculares: 10 años de experiencia Total and partial eyebrows reconstruction with folicular unit transplat: 10 years of experience

    OpenAIRE

    Llorens, D.; Planas, J.; Rengel, J.; Ortiz, J.

    2013-01-01

    Las cejas son elementos integrales en el carácter de la cara y en la expresión del espectro de emociones. Su patrón de cabello es complejo: toma varias direcciones y está colocado en diferente posición y con forma distinta en hombres y mujeres. Esta complejidad de características hace de su reconstrucción un reto. Se han establecido tres líneas básicas para conseguir dicho fin: injertos compuestos, colgajos y trasplante de unidades foliculares. Exponemos la experiencia de 10 años en la recons...

  13. Papel del óxido nítrico durante la recirculación normotérmica en el trasplante hepático experimental en cerdos con donantes a corazón parado.

    OpenAIRE

    Barros Schelotto, Hugo Pablo Luis

    2001-01-01

    [spa] Debido a la falta de órganos para trasplantes, los donantes a corazón parado constituyen una posible fuente de obtención de los mismos. El principal inconveniente que se presenta en tales casos es el tiempo de "isquemia caliente" a la cual están sometidos los órganos. Nuestro grupo investigador ha demostrado que la realización después de la parada cardíaca (PC) de un periodo de recirculación extracorpórea mediante la utilización de una bomba de "bypass" cardiopulmonar y oxigenación tisu...

  14. Efectos de la glutamina parenteral en pacientes sometidos a trasplante de médula ósea Effects of parenteral glutamine in patients submitted to bone marrow transplantation

    OpenAIRE

    C. Gómez Candela; Castillo, R.; A. I. de Cos; IGLESIAS, C; M. C. Martín; Aguado, M J; Ojeda, E.

    2006-01-01

    El Trasplante de Médula Ósea (TMO), es un tratamiento utilizado en las neoplasias malignas hematológicas y tumores sólidos. La quimioterapia y/o radioterapia asociadas a que están sometidos estos pacientes, induce efectos secundarios, con un alto estrés metabólico. La glutamina es considerada como un aminoácido condicionalmente esencial y se ha mostrado eficaz en estados catabólicos severos. El objetivo del estudio fue valorar el efecto del tratamiento con Nutrición Parenteral (NP) suplementa...

  15. Enfermedad Renal Crónica y Terapia Renal Sustitutiva en Pacientes con Infección por el Virus de la Inmunodeficiencia Humana: Prevalencia y Supervivencia en Terapia Renal Sustitutiva (Diálisis y Trasplante Renal)

    OpenAIRE

    Trullás Vila, Joan Carles

    2011-01-01

    INTRODUCCIÓN: Desde la introducción del TARGA la historia natural de la infección por el virus de la inmunodeficiencia humana (VIH) ha cambiado. El descenso en eventos definitorios de SIDA y el aumentado en la supervivencia han hecho que estos pacientes presenten enfermedades órgano-terminales como enfermedad renal crónica (ERC). Existe poca información clínica y epidemiológica respecto los pacientes con infección por el VIH que están en terapia renal sustitutiva (diálisis o trasplante renal ...

  16. Reconstitución de la inmunidad celular T frente a citomegalovirus y control de la viremia en el paciente receptor de trasplante alogénico de precursores hematopoyéticos

    OpenAIRE

    Tormo Palop, Nuria

    2015-01-01

    Durante los últimos años la incidencia de la enfermedad orgánica causada por el Citomegalovirus (EOC) en los pacientes receptores de un trasplante alogénico de células precursoras hemotopoyéticas ha disminuido por el uso profiláctico o anticipado del ganciclovir e, indirectamente, el advenimiento de procedimientos muy sensibles para detectar la presencia del CMV en la sangre periférica (viremia): la PCR y la prueba de la antigenemia pp65 (AG). Aun así, la EOC continúa siendo una causa demasia...

  17. Trasplante de progenitores hematopoyéticos en enfermedades genéticas con régimen de acondicionamiento de intensidad reducida en pacientes pediátricos

    OpenAIRE

    López Granados, Lucía

    2015-01-01

    Introducción: El trasplante de progenitores hematopoyéticos (TPH) consiste en implantar elementos celulares capaces de generar un sistema hematopoyético nuevo y sano. El término régimen de acondicionamiento se refiere al tratamiento que se administra al paciente antes de la infusión de los progenitores hematopoyéticos. El régimen de intensidad reducida (RIR) consiste en un tratamiento predominantemente inmunosupresor para facilitar un implante progresivo con menor morbilidad. Este tipo de aco...

  18. Estudio secuencial y cuantitativo del quimerismo hemopoyético en pacientes sometidos a un trasplante alogénico de progenitores hemopoyéticos con depleción linfoide T o con acondicionamiento sub-mieloablativo.

    OpenAIRE

    Fernández Avilés, Francesc

    2004-01-01

    [spa] El objetivo principal de esta Tesis Doctoral es analizar cual es la frecuencia y la relevancia clínica de la persistencia de células linfoides T y de células mieloides originarias del receptor (quimerismo mixto) tras un trasplante alogénico de progenitores hemopoyéticos. La hipótesis de trabajo es comprobar si el estudio secuencial y cuantitativo del patrón de quimerismo mixto en linfocitos T y en neutrófilos permite predecir el rechazo del injerto alogénico o la recidiva leucémica, res...

  19. Trasplante de médula ósea: abordaje de la Terapia Ocupacional = Transplant of bony marrow : boarding th Occupational Theapy

    Directory of Open Access Journals (Sweden)

    Alahmar Bianchin, M

    2007-09-01

    Full Text Available ResumenEl trasplante de médula ósea (TMO es una modalidad terapéutica que se utiliza en una variedad de enfermedades oncológicas y hematológicas, con el objetivo de prolongar la remisión completa o la cura de la enfermedad. La unidad de TMO del Hospital de Base de San José Del Río Preto - San Pablo, Brasil, cuenta con un equipo formado por doctores, enfermeros, terapeuta ocupacional, psicólogo, nutricionista y asistente social. El estudio presente tiene por objetivo describir la importancia de la intervención de la Terapia Ocupacional a través del uso de actividades en la fase de aislamiento que conlleva el TMO, proporcionando así, una mejor aceptación y adaptación en relación al tratamiento SummaryBone Marrow Transplant is a therapeutical procedure that has been very used in a variety of oncological illnesses, also in hereditary and acquired hematologica illnesses, whith the objective to draw out illness complete remission or the cure. During the isolation of bone marrow transplant unit, many are the psycopathological reartions that patients can present in treatment adaptation period. With the intention of assisting the customer during this phase, the occupational therapy aims at this context, to supply a quality treatment, through activities with objective to raise they self- esteern, to diminish the ideness, to reduce stress it among othres generated for the illness. Therefore when carrying though much activities the costumer will be able to live since a simple satisfaction moment lentil one better acceptance and treatment adaptation.

  20. Trasplante de células progenitoras hematopoyéticas en enfermedades autoinmunes Hematopoietic stem cell transplantation in autoimmune diseases

    Directory of Open Access Journals (Sweden)

    Flavio Albarracín

    2008-04-01

    Full Text Available El trasplante de células progenitoras hematopoyéticas, células con capacidad de autorrenovación y reconstitución de todos los tipos de células sanguíneas, se utiliza en el tratamiento de numerosas enfermedades potencialmente letales incluyendo leucemias y linfomas. Hoy en día es posible además aplicarlo en el tratamiento de enfermedades autoinmunes graves, como esclerosis múltiple, lupus eritematoso sistémico o esclerosis sistémica, resistentes a la terapia convencional. Estudios en modelos animales nos demuestran que la transferencia de células progenitoras hematopoyéticas podría revertir el proceso de autoinmunidad, un fenómeno que puede explicarse mediante diferentes mecanismos. El resultado de los estudios clínicos que se están llevando a cabo, así como también estudios en pacientes y modelos animales, ayudarán a determinar el rol que el transplante de células progenitoras hematopoyéticas puede jugar en el tratamiento de enfermedades autoinmunes.Transplantation of hematopoietic stem cells, which are capable of self renewal and reconstitution of all types of blood cells, can be a treatment for numerous potential lethal diseases, including leukemias and lymphomas. It may now be applicable for the treatment of severe autoimmune diseases, such as therapy-resistant multiple sclerosis, lupus and systemic sclerosis. Studies in animal models show that the transfer of hematopoietic stem cells can reverse autoimmunity. The outcome of ongoing clinical trials, as well as of studies in patients and animal models, will help to determine the role that stem-cell transplantation can play in the treatment of autoimmune diseases.

  1. Pseudoscalar decay constants, light-quark masses, and B_K from mixed-action lattice QCD

    CERN Document Server

    Laiho, Jack

    2011-01-01

    We present updated results for the leptonic decay constants f_pi and f_K, the light u, d, and s-quark masses, and the neutral kaon mixing parameter B_K from mixed-action lattice simulations with staggered sea quarks and domain-wall valence quarks. We use the publicly-available 2+1 flavor MILC asqtad-improved staggered gauge configurations with multiple light sea-quark masses and three lattice spacings, and compute the kaon mixing matrix element with several partially-quenched valence-quark masses. We then extrapolate to the physical light-quark masses and the continuum using partially-quenched chiral perturbation theory formulated for mixed-action lattice simulations. For B_K we match the lattice four-fermion operator to the continuum using the nonperturbative method of Rome-Southampton. Our new results benefit from two significant improvements over our published work: (1) we have added a third lattice spacing of a~0.06 fm to better control the continuum extrapolation, and (2) we have implemented a new lattic...

  2. A Spectropolarimetric Comparison of the Type II-Plateau Supernovae SN 2008bk and SN 2004dj

    CERN Document Server

    Leonard, Douglas C; Hillier, D John; Pignata, Giuliano

    2011-01-01

    The Type II-Plateau supernova (SN II-P) SN 2004dj was the first SN II-P for which spectropolarimetry data were obtained with fine temporal sampling before, during, and after the fall off of the photometric plateau -- the point that marks the transition from the photospheric to the nebular phase in SNe II-P. Unpolarized during the plateau, SN 2004dj showed a dramatic spike in polarization during the descent off of the plateau, and then exhibited a smooth polarization decline over the next two hundred days. This behavior was interpreted by Leonard et al. (2006) as evidence for a strongly non-spherical explosion mechanism that had imprinted asphericity only in the innermost ejecta. In this brief report, we compare nine similarly well-sampled epochs of spectropolarimetry of the Type II-P SN 2008bk to those of SN 2004dj. In contrast to SN 2004dj, SN 2008bk became polarized well before the end of the plateau and also retained a nearly constant level of polarization through the early nebular phase. Curiously, althou...

  3. Properties of BK-type Ca++-dependent K+ channel currents in medial prefrontal cortex (PFC pyramidal neurons in rats of different ages

    Directory of Open Access Journals (Sweden)

    Bartłomiej Paweł Szulczyk

    2013-10-01

    Full Text Available The medial prefrontal cortex (PFC is involved in cognitive functions, which undergo profound changes during adolescence. This alteration of the PFC function derives from neuron activity, which, in turn, may depend on age-dependent properties and the expression of neuronal ion channels. BK-type channels are involved in controlling both the Ca++ ion concentration in the cell interior and cell excitability. The purpose of this study was to test the properties of BK currents in the medial PFC pyramidal neurons of young (18–22-day-old, adolescent (38–42-day-old and adult (58–62-day-old rats. Whole-cell currents evoked by depolarizing voltage steps were recorded from dispersed medial PFC pyramidal neurons. A selective BK channel blocker – paxilline (10 µM – irreversibly decreased the non-inactivating K+ current in neurons that were isolated from the young and adult rats. This current was not significantly affected by paxilline in the neurons obtained from adolescent rats. The properties of single-channel K+ currents were recorded from the soma of dispersed medial PFC pyramidal neurons in the cell-attached configuration. Of the K+ channel currents that were recorded, ~90% were BK and leak channel currents. The BK-type channel currents were dependent on the Ca++ concentration and the voltage and were inhibited by paxilline. The biophysical properties of the BK channel currents did not differ among the pyramidal neurons isolated from young, adolescent and adult rats. Among all of the recorded K+ channel currents, 38.9%, 12.7% and 21.1% were BK-type channel currents in the neurons isolated from the young, adolescent and adult rats, respectively. Furthermore, application of paxilline effectively prolonged the half-width of the action potential in pyramidal neurons in slices isolated from young and adult rats but not in neurons isolated from adolescent rats. We conclude that the availability of BK channel currents decreases in medial PFC

  4. Voltage-dependent Ca2+ channels, not ryanodine receptors, activate Ca2+-dependent BK potassium channels in human retinal pigment epithelial cells

    OpenAIRE

    Wimmers, Sönke; Halsband, Claire; Seyler, Sebastian; Milenkovic, Vladimir; Strauß, Olaf

    2008-01-01

    Purpose In different tissues the activation of large conductance Ca2+-activated (BK) potassium channels has been shown to be coupled to voltage-gated Ca2+ channels as well as ryanodine receptors. As activation of BK channels leads to hyperpolarization of the cell, these channels provide a negative feedback mechanism for Ca2+-induced functions. Many cellular functions of the retinal pigment epithelium (RPE) are coupled to changes in [Ca2+]i. The aim of this study was to identify which Ca2+-ent...

  5. Synthesis of a Biotin Derivative of Iberiotoxin: Binding Interactions with Streptavidin and the BK Ca2+-activated K+ Channel Expressed in a Human Cell Line

    OpenAIRE

    Bingham, Jon-Paul; Bian, Shumin; Tan, Zhi-Yong; Takacs, Zoltan; Moczydlowski, Edward

    2006-01-01

    Iberiotoxin (IbTx) is a scorpion venom peptide that inhibits BK Ca2+-activated K+ channels with high affinity and specificity. Automated solid phase synthesis was used to prepare a biotin-labeled derivative (IbTx-LC-biotin) of IbTx by substitution of Asp19 of the native 37-residue peptide with N-ε-(d-biotin-6-amidocaproate)-l-lysine. Both IbTx-LC-biotin and its complex with streptavidin (StrAv) block single BK channels from rat skeletal muscle with nanomolar affinity, indicating that the biot...

  6. 肾移植术后BK病毒相关性肾病的研究现状%Study on BK virus-associated nephropathy after renal transplantation

    Institute of Scientific and Technical Information of China (English)

    肖荆; 田野

    2008-01-01

    BACKGROUND: BK viral infection after renal transplantation influences the prognosis of BK virus-associated nephropathy in renal transplant recipients. The disease has been widely studied in foreign countries.OBJECTIVE: This study was designed to sum up the diagnosis and treatment of BK virus-associated nephropathy after renal transplantation.RETRIVAL STRATEGY: Using the terms "renal transplantation; BK virus" in the English language, manuscripts responsible for BK virus-associated nephropathy after renal transplantation that were published from January 2000 to January 2007 were retrieved from the PubMed database. A total of 206 manuscripts were obtained and primarily screened. Inclusion criteria: studies addressing BK virus-associated nephropathy after renal transplantation. Exclusion criteria: repetitive studies.LITERATURE EVALUATION: The included manuscripts were primarily from PubMed database. Manuscripts were primarily original and review studies.DATA SYNTHESIS: BK virus can be found in the urine of 3%-40% of adult renal transplant recipients. BK virus reactivation rate is very high, but the histological manifestations of BK virus associated nephropathy are found only in a small number of renal transplant recipients. The prognosis of BK virus associated nephropathy is very poor. BK virus associated nephropathy develops into renal failure, leading to transplant loss, in 30%-50% patients. BK virus-caused renal transplant disease must be diagnosed according to histological manifestations. Viral infection should be primarily confirmed, but serological measurements have no predominant effects. Electron microscopy should be involved in the assessment of renal graft biopsy, especially when renal failure factors are unknown, as through the use of electron microscope, viral particles in the nucleus, cytoplasm and outside of the cells could be detectable. Viral antigen in the urine sample of patients with BK viruria can be detected by nucleic acid hybridization method

  7. La práctica de la diligencia judicial de autopsia en los supuestos de fallecidos en los que se han extraído órganos para su trasplante

    Directory of Open Access Journals (Sweden)

    P.J. Pérez Jorge

    2015-06-01

    Full Text Available En España, el número de donaciones de fallecidos judiciales es mayor que en otros países de nuestro entorno, posiblemente porque el modelo español facilita en gran medida la interconexión activa entre el médico forense, el Juez de guardia y los coordinadores de trasplantes. Desde esta perspectiva humana, enaltece a la sociedad, basándose en la solidaridad y el altruismo por parte del donante y su familia. También la dota de un alto nivel sociocultural y técnico, tanto por la cantidad como por la calidad de los profesionales que intervienen en todo el operativo de trasplantes. En el presente trabajo se analiza la intervención judicial y del médico forense en las donaciones de órganos de cadáveres judiciales, enfatizando sobre las situaciones que en la práctica se pueden producir con respecto a las autopsias, así como en la necesidad de planes de actuación y protocolos que faciliten la intervención de los distintos operadores implicados para minimizar, en la medida de lo posible, el número de negativas judiciales.

  8. Energy levels of 249Bk populated in the α decay of 99253Es and β- decay of 96249Cm

    International Nuclear Information System (INIS)

    The level structure of 249Bk has been investigated by measuring the γ-ray spectra of an extremely pure 253Es sample obtained by milking this nuclide from 253Cf source material produced in the High Flux Isotope Reactor at Oak Ridge National Laboratory. Additional information on the 249Bk levels was obtained from the β--decay study of 249Cm, produced by neutron irradiation of 248Cm. Using the results of the present study together with the data from previous 248Cm(α,t) and 248Cm(3He,d) reactions, the following single-particle states have been identified in 249Bk: 7/2+[633], 0.0 keV; 3/2-[521], 8.78 keV; 1/2+[400], 377.55 keV; 5/2+[642], 389.17 keV; 1/2-[530], 569.20 keV; 1/2-[521], 643.0 keV; 5/2-[523], 672.9 keV; and 9/2+[624], 1075.1 keV. Four vibrational bands were identified at 767.9, 932.2, 1150.7, and 1223.0 keV with tentative assignments of {7/2+ [633] x1-}9/2-, {7/2+ [633] x 0-}7/2-, {7/2+ [633] x 1-}5/2-, and {7/2+ [633] x 0+}7/2+, respectively. A band at 899.9 keV was observed in γ-γ coincidence measurements and given a tentative spin assignment of 3/2. It is possibly associated with a 2- phonon coupled to the ground state, with configuration {7/2+ [633] x 2-}3/2-. Three levels at 624.3, 703.5, and 769.1 keV were assigned spins of 5/2, 7/2, and 9/2, respectively. These could be the members of the 3/2+ [651] band, expected in this energy region

  9. No detection of BK virus, JC virus, KI, WU and Merkel cell polyomaviruses in cerebrospinal fluid of patients with neurological complications after hematopoetic stem cell transplantation.

    Science.gov (United States)

    Rubin, J; Giraud, G; Priftakis, P; Wide, K; Gustafsson, B; Ramqvist, T; Dalianis, T

    2011-10-01

    Neurological complications, often due to viral reactivation, after allogeneic hematopoetic stem cell transplantation (HSCT) are associated with increased mortality. Here, cerebrospinal fluid from 20 HSCT patients with neurological symptoms were analyzed and found to be negative by PCR for BK virus, JC virus, KI, WU and Merkel cell polyomavirus DNA. PMID:21965766

  10. Association between a High BK Virus Load in Urine Samples of Patients with Graft-Versus-Host Disease and Development of Hemorrhagic Cystitis after Hematopoietic Stem Cell Transplantation

    OpenAIRE

    Bogdanovic, G; Priftakis, P.; Giraud, G.; Kuzniar, M.; Ferraldeschi, R; Kokhaei, P.; Mellstedt, H.; Remberger, M; Ljungman, P.; Winiarski, J.; Dalianis, T

    2004-01-01

    BK virus (BKV) load in urine alone or in combination with acute graft-versus-host disease (GVHD) was correlated to development of hemorrhagic cystitis (HC). BKV load in combination with acute GVHD discriminated the best, while BKV and viral load alone, but not GVHD, still showed predictive ability for HC.

  11. The BMS Equation and c\\bar{c} Production; A Comparison of the BMS and BK Equations

    CERN Document Server

    Marchesini, Giuseppe

    2015-01-01

    We introduce two processes where the BMS equation appears in a context quite different from the original context of non-global jet observables. We note the strong similarities of the BMS equation to the BK and FKPP equations and argue that these, essentially identical equations, can be viewed either in terms of the probability, or amplitude, of something not happening or in terms of the nonlinear terms setting unitarity limits. Mostly analytic solutions are given for (i) the probability that no $c\\bar{c}$ pairs be produced in a jet decay and (ii) the probability that no-$c\\bar{c}$ pairs be produced in a high energy dipole nucleus scattering. Both these processes obey BMS equations, albeit with very different kernels.

  12. No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses.

    Directory of Open Access Journals (Sweden)

    Harriet C T Groom

    Full Text Available The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV Envelope. No reactivity was found in the patient samples. In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques. Despite demonstrating DNA integrity and assay sensitivity, we failed to detect the presence of any of these agents in DNA samples, bar one sample that was weakly positive for HPV16. Therefore we conclude that these infections are absent in this typical cohort of men with prostate cancer.

  13. New insights on the association between the prostate cancer and the small DNA tumour virus, BK polyomavirus.

    Science.gov (United States)

    Tognon, Mauro; Provenzano, Maurizio

    2015-01-01

    In recent years the scientific literature in the field of the prostate carcinoma (PCa) pointed out on the genetic heterogeneity and mutations occurring in this tumour, while little attention was given to the causes of PCa onset, in particular infectious agents. In this brief commentary, we wish to point out recent advancements done on the role of the human polyomavirus BK (BKPyV) in the development of PCa by harnessing both humoral and cellular immune responses. Altogether, these new insights suggest that BKPyV is involved in the transforming activity during the multistep process of PCa development. Although these findings do not provide evidence for a causal relationship between BKPyV and PCa development, additional investigations with novel techniques will help to make it a concrete event. PMID:26699530

  14. A fast BK-type KCa current acts as a postsynaptic modulator of temporal selectivity for communication signals

    Directory of Open Access Journals (Sweden)

    Tsunehiko Kohashi

    2014-09-01

    Full Text Available Temporal patterns of spiking often convey behaviorally relevant information. Various synaptic mechanisms and intrinsic membrane properties can influence neuronal selectivity to temporal patterns of input. However, little is known about how synaptic mechanisms and intrinsic properties together determine the temporal selectivity of neuronal output. We tackled this question by recording from midbrain electrosensory neurons in mormyrid fish, in which the processing of temporal intervals between communication signals can be studied in a reduced in vitro preparation. Mormyrids communicate by varying interpulse intervals (IPIs between electric pulses. Within the midbrain posterior exterolateral nucleus (ELp, the temporal patterns of afferent spike trains are filtered to establish single-neuron IPI tuning. We performed whole-cell recording from ELp neurons in a whole-brain preparation and examined the relationship between intrinsic excitability and IPI tuning. We found that spike frequency adaptation of ELp neurons was highly variable. Postsynaptic potentials (PSPs of strongly adapting (phasic neurons were more sharply tuned to IPIs than weakly adapting (tonic neurons. Further, the synaptic filtering of IPIs by tonic neurons was more faithfully converted into variation in spiking output, particularly at short IPIs. Pharmacological manipulation under current- and voltage-clamp revealed that tonic firing is mediated by a fast, large-conductance Ca2+-activated K+ (KCa current (BK that speeds up action potential repolarization. These results suggest that BK currents can shape the temporal filtering of sensory inputs by modifying both synaptic responses and PSP-to-spike conversion. Slow SK-type KCa currents have previously been implicated in temporal processing. Thus, both fast and slow KCa currents can fine-tune temporal selectivity.

  15. Establecimiento de las condiciones para el trasplante de células de médula ósea en un modelo de enfermedad de Huntington y su efecto funcional a través de la conducta motora

    Directory of Open Access Journals (Sweden)

    Teresa Serrano Sánchez

    2012-06-01

    Full Text Available Título en ingles: Establishment of the conditions for the bone marrow cells transplants in a model of Huntington´s disease and functional effect on the motor  behavior Resumen  La enfermedad de Huntington  (EH es un trastorno degenerativo hereditario que afecta a personas con predisposición genética. No existe hasta hoy un tratamiento efectivo; la enfermedad avanza lentamente y el paciente termina en incapacidad o muerte después de 15 o 20 años. Los estudios relacionados con el tratamiento de las manifestaciones clínicas que aparecen en la enfermedad, incluyen tratamientos medicamentosos y el uso de trasplante de células. En la actualidad se conoce que es posible reproducir  algunas características de la enfermedad en modelos experimentales para ensayar posibles terapéuticas (ej. el modelo de lesión estriatal por inyección de ácido quinolínico; [AQ]. No se conoce el efecto restaurativo de las células de médula ósea (CMO en este modelo. Objetivos: 1 Caracterizar  morfológicamente la lesión por inyección intraestriatal de AQ. 2 Caracterizar inmunocitoquímicamente las CMO. 3 Evaluar la concentración óptima de CMO para el trasplante en el modelo y 4 Evaluar el estado funcional del trasplante de CMO, a través de la conducta motora. Resultados: Se estableció la dosis de AQ para lesionar de manera adecuada al estriado, se caracterizaron inmunofenotípicamente las CMO, se estableció la concentración celular óptima para el trasplante de CMO y se realizó la evaluación  funcional del trasplante. Conclusiones: 1 La dosis de 1,2 µL de AQ, fue capaz de lesionar adecuadamente el estriado, con una menor afectación de estructuras fuera del estriado. 2 Las CMO fueron positivas para los marcadores CD34, CD38, CD45 y CD90, lo que sugiere que esta población es heterogénea. 3 La mejor concentración de CMO para el trasplante fue la de 100 000 cél/ml,  ya que se obtuvo la mejor supervivencia y migración celular. 4 Las

  16. Reconstrucción total y parcial de cejas con trasplante de unidades foliculares: 10 años de experiencia Total and partial eyebrows reconstruction with folicular unit transplat: 10 years of experience

    Directory of Open Access Journals (Sweden)

    D. Llorens

    2013-03-01

    Full Text Available Las cejas son elementos integrales en el carácter de la cara y en la expresión del espectro de emociones. Su patrón de cabello es complejo: toma varias direcciones y está colocado en diferente posición y con forma distinta en hombres y mujeres. Esta complejidad de características hace de su reconstrucción un reto. Se han establecido tres líneas básicas para conseguir dicho fin: injertos compuestos, colgajos y trasplante de unidades foliculares. Exponemos la experiencia de 10 años en la reconstrucción de cejas a través del trasplante de unidades foliculares en la Clínica Planas de Barcelona (España con 58 pacientes consecutivos tratados en ese lapso y 94 cejas reconstruidas. Planteamos un estudio retrospectivo, observacional, transverso y descriptivo. Se analizaron la distribución de frecuencias y medidas de tendencia central de las variables. Los resultados obtenidos nos han permitido concluir que la técnica de trasplante de unidades foliculares es la mejor alternativa para la reconstrucción total y parcial de las cejas en casos seleccionados, con minúscula morbilidad, resultados netamente superiores y con una mínima interferencia en la vida del paciente.Eyebrows are integral elements in the character of the face and the expression of the spectrum of emotions. Its hair pattern is complex: it takes several directions and is placed in a different position and differently in men and women. This complexity of features makes reconstruction a challenge. In this way, we have established three basic areas to achieve this end: composite grafts, flaps and follicular units transplant. We report the experience of 10 years in the reconstruction of eyebrows throughout the follicular units transplantation technique at Clínica Planas in Barcelona ( Spain with 58 consecutive patients treated in this period and 94 eyebrows. A retrospective, observational, transverse and descriptive study was raised. We analyzed the frequency distribution and

  17. Resultados de una encuesta sobre donación y trasplante de órganos en la zona metropolitana de Guadalajara, México Survey results regarding organ donation and transplant in metropolitan Guadalajara, Mexico

    OpenAIRE

    Luz Consuelo Zepeda-Romero; Guillermo García-García; Oscar Aguirre-Jaúregui

    2003-01-01

    OBJETIVO: Evaluar el conocimiento y la disposición de la donación de órganos y tejidos con fines de trasplante entre la población adulta del área metropolitana de Guadalajara, Jalisco, México. MATERIAL Y MÉTODOS: Se realizó una encuesta aplicando un cuestionario de 29 reactivos a personas mayores de 18 años de edad, mediante entrevista directa en la vía pública. La zona metropolitana se dividió en cuatro municipios, asignándose a cada uno de éstos el número de encuestas en proporción al númer...

  18. Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells.

    Science.gov (United States)

    Marcantoni, Andrea; Vandael, David H F; Mahapatra, Satyajit; Carabelli, Valentina; Sinnegger-Brauns, Martina J; Striessnig, Joerg; Carbone, Emilio

    2010-01-13

    We studied wild-type (WT) and Cav1.3(-/-) mouse chromaffin cells (MCCs) with the aim to determine the isoform of L-type Ca(2+) channel (LTCC) and BK channels that underlie the pacemaker current controlling spontaneous firing. Most WT-MCCs (80%) were spontaneously active (1.5 Hz) and highly sensitive to nifedipine and BayK-8644 (1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester). Nifedipine blocked the firing, whereas BayK-8644 increased threefold the firing rate. The two dihydropyridines and the BK channel blocker paxilline altered the shape of action potentials (APs), suggesting close coupling of LTCCs to BK channels. WT-MCCs expressed equal fractions of functionally active Cav1.2 and Cav1.3 channels. Cav1.3 channel deficiency decreased the number of normally firing MCCs (30%; 2.0 Hz), suggesting a critical role of these channels on firing, which derived from their slow inactivation rate, sizeable activation at subthreshold potentials, and close coupling to fast inactivating BK channels as determined by using EGTA and BAPTA Ca(2+) buffering. By means of the action potential clamp, in TTX-treated WT-MCCs, we found that the interpulse pacemaker current was always net inward and dominated by LTCCs. Fast inactivating and non-inactivating BK currents sustained mainly the afterhyperpolarization of the short APs (2-3 ms) and only partially the pacemaker current during the long interspike (300-500 ms). Deletion of Cav1.3 channels reduced drastically the inward Ca(2+) current and the corresponding Ca(2+)-activated BK current during spikes. Our data highlight the role of Cav1.3, and to a minor degree of Cav1.2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress. PMID:20071512

  19. La Poste

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ The French Post Office has issued ten commemorative envelopes bearing original images depicting CERN and its history. This special fiftieth anniversary collector's edition will be available on the French Post Office (« La Poste ») stand at the Open Day on 16 October, in the CMS experiment hall at Cessy. Information for collectors: a pictorial postmark and date stamp have been specially designed and produced for the occasion with the assistance of CERN's graphics team. Sending a philatelic souvenir is a great way to commemorate the Open Day, so La Poste will be setting up a large post-box for that very purpose next to its stand. A perfect way to send images of CERN all around the world...

  20. Factores pronósticos de complicaciones postoperatorias en el trasplante hepático Prognostic factors associated with postoperative complications in liver transplantation

    Directory of Open Access Journals (Sweden)

    A. Rodríguez-Ariza

    2008-03-01

    Full Text Available Objetivo: la evolución postoperatoria de los pacientes sometidos a trasplante hepático ortotópico (THO se encuentra frecuentemente asociada a la aparición de diversas complicaciones tales como disfunción renal, rechazo agudo, infecciones y complicaciones neurológicas. Estas complicaciones constituyen las causas más significativas de morbilidad y mortalidad tempranas en pacientes que reciben un THO. El propósito del presente estudio es la identificación de factores relacionados con las distintas complicaciones postoperatorias del THO. Diseño experimental: se llevó a cabo un estudio prospectivo. Pacientes: se analizaron 78 variables en 32 pacientes consecutivos sometidos a THO. Utilizando un análisis de regresión logística se identificaron aquellos factores asociados de forma independiente con la aparición de complicaciones postoperatorias. Resultados: el análisis multivariante demostró que los niveles pretrasplante en suero de malondialdehído y creatinina estaban asociados con el desarrollo de disfunción renal. Los niveles pretrasplante de hemoglobina y las unidades de plaquetas administradas durante la cirugía fueron factores pronósticos de infecciones. El rechazo agudo fue pronosticado por los niveles séricos de γ-glutamil transpeptidasa y de bilirrubina total. Los niveles pretrasplante de sodio y glutaredoxina en suero estuvieron asociados con complicaciones neurológicas. Conclusiones: proponemos estos marcadores para la identificación de pacientes de alto riesgo, permitiendo una vigilancia y/o tratamiento anticipados que mejorarán la morbilidad y la supervivencia en pacientes sometidos a THO.Objectives: the postoperative evolution of patients submitted to orthotopic liver transplant (OLT is frequently associated with the appearance of different types of complications such as renal failure, graft rejection, infections, and neurological disorders. These complications are the most significant causes of early morbidity

  1. Marketingová situační analýza BK Lions Jindřichův Hradec

    OpenAIRE

    Hron, Patrik

    2014-01-01

    The aim of this bachelor thesis is to carry out an analysis of each part of marketing mix and the environment in which the BK Lions Jindřichův Hradec basketball club is situated. Suitable and applicable recommendations are suggested to make the marketing mix more effective based on analysis of marketing situation. The first part is focused on describing the marketing mix and marketing situational analysis at a theoretical level. The practical part describes particular marketing tools which ar...

  2. Gentamicin Blocks the ACh-Induced BK Current in Guinea Pig Type II Vestibular Hair Cells by Competing with Ca2+ at the l-Type Calcium Channel

    Directory of Open Access Journals (Sweden)

    Hong Yu

    2014-04-01

    Full Text Available Type II vestibular hair cells (VHCs II contain big-conductance Ca2+-dependent K+ channels (BK and L-type calcium channels. Our previous studies in guinea pig VHCs II indicated that acetylcholine (ACh evoked the BK current by triggering the influx of Ca2+ ions through l-type Ca2+ channels, which was mediated by M2 muscarinic ACh receptor (mAChRs. Aminoglycoside antibiotics, such as gentamicin (GM, are known to have vestibulotoxicity, including damaging effects on the efferent nerve endings on VHCs II. This study used the whole-cell patch clamp technique to determine whether GM affects the vestibular efferent system at postsynaptic M2-mAChRs or the membrane ion channels. We found that GM could block the ACh-induced BK current and that inhibition was reversible, voltage-independent, and dose-dependent with an IC50 value of 36.3 ± 7.8 µM. Increasing the ACh concentration had little influence on GM blocking effect, but increasing the extracellular Ca2+ concentration ([Ca2+]o could antagonize it. Moreover, 50 µM GM potently blocked Ca2+ currents activated by (--Bay-K8644, but did not block BK currents induced by NS1619. These observations indicate that GM most likely blocks the M2 mAChR-mediated response by competing with Ca2+ at the l-type calcium channel. These results provide insights into the vestibulotoxicity of aminoglycoside antibiotics on mammalian VHCs II.

  3. Evaluation of the Genetic Variation of Non Coding Control Region of BK Virus Using Nested-PCR Sequencing Method in Renal Graft Patients

    Directory of Open Access Journals (Sweden)

    A Emami

    2015-05-01

    Full Text Available Background & aim: Polyomaviruses (BK is a comprehensive infection with more than of 80% prevalence in the world. One of the most important reasons of BK virus nephropathy is in the renal transplant recipients and rejection of transplanted tissue between them. Non Coding region of this virus play a regulatory role in replication and amplification of the virus. The aim of this study was to evaluate the genetic patterns of this area in renal graft at Namazi Transplantation Center, Shiraz, Iran. Methods: In the present experimental study, 380 renal allograft serums were collected. DNAs of 129 eligible samples were extracted and evaluated using a virus genome. The presence of the virus was determined by qualitative and sequencing. Of these, 129 samples were tested for the presence of virus according to the condition study, using quantitative, qualitative genomic amplification and sequencing. Results: The study showed symptoms of nephropathy, 76 (58.9% of them were males and 46 (35.7% were females with the mean age 38.0±.089 years of age. In general, 46 patients (35.7% percent were positive for BK Polyomaviruses. After comparing the genomic sequence with applications of molecular they were categorized in three groups and then recorded in gene bank. Conclusion: About 35% of renal transplant recipients with high creatinine levels were positive for the presence of BK virus. Non-coding region of respondents in the sample survey revealed that among patients with the most common genotypes were rearranged the entire transplant patients were observed at this tranplant center. Examination of these sequences indicated that this rearrangments had a specific pattern, different from the standard strain of archaea type.

  4. Clinical polyomavirus BK variants with agnogene deletion are non-functional but rescued by trans-complementation

    International Nuclear Information System (INIS)

    High-level replication of polyomavirus BK (BKV) in kidney transplant recipients is associated with the emergence of BKV variants with rearranged (rr) non-coding control region (NCCR) increasing viral early gene expression and cytopathology. Cloning and sequencing revealed the presence of a BKV quasispecies which included non-functional variants when assayed in a recombinant virus assay. Here we report that the rr-NCCR of BKV variants RH-3 and RH-12, both bearing a NCCR deletion including the 5' end of the agnoprotein coding sequence, mediated early and late viral reporter gene expression in kidney cells. However, in a recombinant virus they failed to produce infectious progeny despite large T-antigen and VP1 expression and the formation of nuclear virus-like particles. Infectious progeny was generated when the agnogene was reconstructed in cis or agnoprotein provided in trans from a co-existing BKV rr-NCCR variant. We conclude that complementation can rescue non-functional BKV variants in vitro and possibly in vivo.

  5. Prevalence of JC and BK polyomavirus excretion in the urine of HIV-infected patients from Serbia

    Directory of Open Access Journals (Sweden)

    Karalić Danijela

    2014-01-01

    Full Text Available BK virus (BKV and JC virus (JCV persist as latent infection in the kidneys. Reactivation of both viruses may be linked to immunodeficiency. The aims of this study were to determine the prevalence of BKV and JCV viruria and to evaluate the relationship between immunodeficiency and viruria in a cohort of HIV-infected patients. Urine samples from 93 HIV-infected patients were collected and tested for the presence of BKV and JCV DNA by PCR. The overall prevalence of polyomavirus DNA in urine was 74.2%. BKV DNA was detected in 30.1% urine samples and JCV DNA in 23.7% samples. Both BKV and JCV DNA were detected in 20.4% samples. There was no association between BKV/JCV urinary shedding and the degree of immunosuppression measured by CD4+ cell count. However, taking into account the severity of disease resulting from reactivation of BKV and JCV, patients with HIV/polyomavirus co-infection should be kept under frequent and regular supervision. [Projekat Ministarstva nauke Republike Srbije, br. 175073

  6. Distinct BK polyomavirus non-coding control region (NCCR) variants in oral fluids of HIV- associated Salivary Gland Disease patients.

    Science.gov (United States)

    Burger-Calderon, Raquel; Ramsey, Kathy J; Dolittle-Hall, Janet M; Seaman, William T; Jeffers-Francis, Liesl K; Tesfu, Daniel; Nickeleit, Volker; Webster-Cyriaque, Jennifer

    2016-06-01

    HIV-associated Salivary Gland Disease (HIVSGD) is among the most common salivary gland-associated complications in HIV positive individuals and was associated with the small DNA tumorvirus BK polyomavirus (BKPyV). The BKPyV non-coding control region (NCCR) is the main determinant of viral replication and rearranges readily. This study analyzed the BKPyV NCCR architecture and viral loads of 35 immunosuppressed individuals. Throatwash samples from subjects diagnosed with HIVSGD and urine samples from transplant patients were BKPyV positive and yielded BKPyV NCCR sequences. 94.7% of the BKPyV HIVSGD NCCRs carried a rearranged OPQPQQS block arrangement, suggesting a distinct architecture among this sample set. BKPyV from HIV positive individuals without HIVSGD harbored NCCR block sequences that were distinct from OPQPQQS. Cloned HIVSGD BKPyV isolates displayed active promoters and efficient replication capability in human salivary gland cells. The unique HIVSGD NCCR architecture may represent a potentially significant oral-tropic BKPyV substrain. PMID:27085139

  7. Trasplante hepático

    OpenAIRE

    J. I. Herrero; Pardo, F.; J Quiroga; F. Rotellar

    2006-01-01

    Liver transplantation is an efficient therapeutic option for terminal hepatic diseases. The principal indications of liver transplantation are hepatic cirrhosis, hepatic tumours (mainly, hepotocellular carcinoma) and acute liver failure. Over the years, the absolute contraindications for a transplant have lessened. Surgical techniques have also undergone changes. The results of liver transplant have improved so that survival one year after the transplant is close to ...

  8. Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.

    Science.gov (United States)

    Rho, Okkyung; Kiguchi, Kaoru; Jiang, Guiyu; DiGiovanni, John

    2014-11-01

    In this study, we examined the impact of rapamycin on mTORC1 signaling during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced keratinocyte proliferation and skin tumor promotion in both wild-type (FVB/N) and BK5.Akt(WT) mice. TPA activated mTORC1 signaling in a time-dependent manner in cultured primary mouse keratinocytes and a mouse keratinocyte cell line. Early activation (15-30 min) of mTORC1 signaling induced by TPA was mediated in part by PKC activation, whereas later activation (2-4 h) was mediated by activation of EGFR and Akt. BK5.Akt(WT) transgenic mice, where Akt1 is overexpressed in basal epidermis, are highly sensitive to TPA-induced epidermal proliferation and two-stage skin carcinogenesis. Targeting mTORC1 with rapamycin effectively inhibited TPA-induced epidermal hyperplasia and hyperproliferation as well as tumor promotion in a dose-dependent manner in both wild-type and BK5.Akt(WT) mice. A significant expansion (∼threefold) of the label retaining cell (LRC) population per hair follicle was observed in BK5.Akt(WT) mice compared to FVB/N mice. There was also a significant increase in K15 expressing cells in the hair follicle of transgenic mice that coincided with expression of phospho-Akt, phospho-S6K, and phospho-PRAS40, suggesting an important role of mTORC1 signaling in bulge-region keratinocyte stem cell (KSC) homeostasis. After 2 weeks of TPA treatment, LRCs had moved upward into the interfollicular epidermis from the bulge region of both wild-type and BK5.Akt(WT) mice. TPA-mediated LRC proliferation and migration was significantly inhibited by rapamycin. Collectively, the current data indicate that signaling through mTORC1 contributes significantly to the process of skin tumor promotion through effects on proliferation of the target cells for tumor development. PMID:24114993

  9. Computed Tomography Findings of Human Polyomavirus BK (BKV)-Associated Cystitis in Allogeneic Hematopoietic Stem Cell Transplant Recipients

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, M.; Beck, R.; Igney, A.; Vogel, M.; Maksimovic, O.; Claussen, C.D.; Faul, C.; Horger, M. [Dept. of Diagnostic Radiology, Dept. of Internal Medicine-Oncology, and Inst. of Medical Virology, Eberhard-Karls Univ., Tbingen (Germany)

    2008-12-15

    Background: Over 70% of the general population worldwide is positive for antibodies against polyomavirus hominis type 1 (BKV). Polyomavirus can be reactivated in immunocompromised patients and thereby induce urogenital tract infection, including cystitis. Purpose: To describe the computed tomography (CT) findings of human polyomavirus-induced cystitis in adult patients after allogeneic hematopoietic stem cell transplantation (allogeneic HCT). Material and Methods: The study population was a retrospective cohort of 11 consecutive adult patients (eight men, three women; age range 22-59 years, mean 42.9 years) who received allogeneic HCT between December 2003 and December 2007 and were tested positive for urinary BKV infection. All CT scans were evaluated with regard to bladder wall thickness, mucosal enhancement, distinct layering of thickened bladder wall, and presence of intravesical clots, perivesical stranding as well as attenuation values of intravesical urine. Clinical data concerning transplant and conditioning regimen variables and laboratory parameters were correlated with degree and extent of imaging findings. Results: All patients had clinical signs of cystitis with different degrees of thickening of the urinary bladder wall. Well-delineated urinary bladder layers were present in six patients. Thickening of the urinary bladder wall was continuous in nine of 11 patients. Increased attenuation of intravesical urine was found in seven patients with hemorrhagic cystitis. Four patients had intraluminal clots. Perivesical stranding was not a major CT finding, occurring in a mild fashion in three of 11 patients. The clinical classification of hemorrhagic cystitis did not correlate with the analyzed imaging parameters. Patient outcome was not influenced by this infectious complication. Conclusion: CT findings in patients with polyomavirus BK cystitis consist of different degrees of bladder wall thickening usually with good delineation of all mural layers and

  10. Computed Tomography Findings of Human Polyomavirus BK (BKV)-Associated Cystitis in Allogeneic Hematopoietic Stem Cell Transplant Recipients

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, M.; Beck, R.; Igney, A.; Vogel, M.; Maksimovic, O.; Claussen, C.D.; Faul, C.; Horger, M. (Dept. of Diagnostic Radiology, Dept. of Internal Medicine-Oncology, and Inst. of Medical Virology, Eberhard-Karls Univ., Tbingen (Germany))

    2008-12-15

    Background: Over 70% of the general population worldwide is positive for antibodies against polyomavirus hominis type 1 (BKV). Polyomavirus can be reactivated in immunocompromised patients and thereby induce urogenital tract infection, including cystitis. Purpose: To describe the computed tomography (CT) findings of human polyomavirus-induced cystitis in adult patients after allogeneic hematopoietic stem cell transplantation (allogeneic HCT). Material and Methods: The study population was a retrospective cohort of 11 consecutive adult patients (eight men, three women; age range 22-59 years, mean 42.9 years) who received allogeneic HCT between December 2003 and December 2007 and were tested positive for urinary BKV infection. All CT scans were evaluated with regard to bladder wall thickness, mucosal enhancement, distinct layering of thickened bladder wall, and presence of intravesical clots, perivesical stranding as well as attenuation values of intravesical urine. Clinical data concerning transplant and conditioning regimen variables and laboratory parameters were correlated with degree and extent of imaging findings. Results: All patients had clinical signs of cystitis with different degrees of thickening of the urinary bladder wall. Well-delineated urinary bladder layers were present in six patients. Thickening of the urinary bladder wall was continuous in nine of 11 patients. Increased attenuation of intravesical urine was found in seven patients with hemorrhagic cystitis. Four patients had intraluminal clots. Perivesical stranding was not a major CT finding, occurring in a mild fashion in three of 11 patients. The clinical classification of hemorrhagic cystitis did not correlate with the analyzed imaging parameters. Patient outcome was not influenced by this infectious complication. Conclusion: CT findings in patients with polyomavirus BK cystitis consist of different degrees of bladder wall thickening usually with good delineation of all mural layers and

  11. Computed Tomography Findings of Human Polyomavirus BK (BKV)-Associated Cystitis in Allogeneic Hematopoietic Stem Cell Transplant Recipients

    International Nuclear Information System (INIS)

    Background: Over 70% of the general population worldwide is positive for antibodies against polyomavirus hominis type 1 (BKV). Polyomavirus can be reactivated in immunocompromised patients and thereby induce urogenital tract infection, including cystitis. Purpose: To describe the computed tomography (CT) findings of human polyomavirus-induced cystitis in adult patients after allogeneic hematopoietic stem cell transplantation (allogeneic HCT). Material and Methods: The study population was a retrospective cohort of 11 consecutive adult patients (eight men, three women; age range 22-59 years, mean 42.9 years) who received allogeneic HCT between December 2003 and December 2007 and were tested positive for urinary BKV infection. All CT scans were evaluated with regard to bladder wall thickness, mucosal enhancement, distinct layering of thickened bladder wall, and presence of intravesical clots, perivesical stranding as well as attenuation values of intravesical urine. Clinical data concerning transplant and conditioning regimen variables and laboratory parameters were correlated with degree and extent of imaging findings. Results: All patients had clinical signs of cystitis with different degrees of thickening of the urinary bladder wall. Well-delineated urinary bladder layers were present in six patients. Thickening of the urinary bladder wall was continuous in nine of 11 patients. Increased attenuation of intravesical urine was found in seven patients with hemorrhagic cystitis. Four patients had intraluminal clots. Perivesical stranding was not a major CT finding, occurring in a mild fashion in three of 11 patients. The clinical classification of hemorrhagic cystitis did not correlate with the analyzed imaging parameters. Patient outcome was not influenced by this infectious complication. Conclusion: CT findings in patients with polyomavirus BK cystitis consist of different degrees of bladder wall thickening usually with good delineation of all mural layers and

  12. Monitoring post

    DEFF Research Database (Denmark)

    Hansen, Pelle Guldborg; Jespersen, Andreas Maaløe

    2013-01-01

    This blog reports on the rumour that White House considers establishing a nudge unit similar to the UK Behavioural Insights Team. Given The Nudging Networks purpose and the work of the iNudgeYou-team this post is updated continuously to follow the US debate as it unfolds. Which issues are raised?......? How is the debate different from the one in the UK? And how does our work relate to the issues raised? The post has already been referenced in several US media, including US News....

  13. Propiedades psicométricas de un cuestionario específico de calidad de vida en trasplante hepático Psychometric properties of a quality of life questionnaire specific to liver transplant

    Directory of Open Access Journals (Sweden)

    B. Estraviz

    2007-01-01

    Full Text Available Objetivo: traducir y evaluar las propiedades psicométricas de un cuestionario de calidad de vida específico para pacientes sometidos a trasplante hepático. Material y métodos: el cuestionario fue administrado a 60 pacientes en lista de espera de trasplante hepático de la Unidad de Trasplante del Hospital de Cruces, y a los 6 meses tras la intervención. Se estudió la fiabilidad, la validez, la sensibilidad al cambio y el mínimo cambio detectable (MCD. Para evaluar la validez convergente se utilizaron dos cuestionarios, SF-36 (Health Survey Short Form 36 y el HAD (Hospital Anxiety and Depression Scale. Resultados: el cuestionario específico presenta un coeficiente alfa de Cronbach superior a 0,7. El análisis factorial demuestra una única dimensión. Las correlaciones con las áreas del SF-36 oscilaron entre -0,34 y -0,71 en el preoperatorio, y entre -0,21 y -0,67 a los 6 meses. Respecto al HAD-ansiedad, los coeficientes eran 0,44 en el preoperatorio y 0,51 a los 6 meses, y para HAD-depresión de 0,64 y 0,39 respectivamente. Los estudios de validez discriminante confirman que el cuestionario muestra diferencias entre pacientes con cirrosis de diversas etiologías o gravedad. En el estudio de la sensibilidad al cambio se obtuvieron unos valores para los índices TEE (tamaño del efecto estandarizado y MRE (media de respuesta estandarizada de 0,92 y 0,99 respectivamente. Además, un 58,33% de los pacientes superaba el MCD. Conclusiones: el cuestionario específico posee adecuadas propiedades psicométricas, lo cual puede aconsejar su utilización en estos pacientes, como otra medida más para evaluar los resultados de esta intervención.Objective: to translate and evaluate the psychometric properties of a quality of life questionnaire specific to liver transplant patients. Material and methods: the questionnaire was administered to 60 patients on the waiting list for liver transplant in the Cruces Hospital Transplant Unit, and again at 6

  14. Trasplante renal y rechazo vascular: Papel de enfermería en el tratamiento con plasmaféresis Kidney transplant and vascular rejection: Role of nursing in treatment with plasmapheresis peritoneal dialysis

    Directory of Open Access Journals (Sweden)

    Maribel Díaz Jurado

    2007-03-01

    Full Text Available La plasmaféresis (PF es una técnica que se aplica en el servicio de trasplante renal (TR de nuestro Hospital desde el año 1999, como tratamiento en el TR que presenta rechazo vascular. Este rechazo puede ser de dos tipos: mediado por anticuerpos o mediado por linfocitos T. El tratamiento con PF consigue eliminar los anticuerpos en sangre del paciente, y por tanto puede ser efectiva en el caso de que el rechazo vascular sea mediado por anticuerpos. La técnica es llevada a cabo por la enfermera de la unidad de trasplante. Esta debe conocer la técnica, los parámetros, sus indicaciones y las posibles complicaciones que puedan presentarse. El objetivo principal de nuestro estudio es ver la efectividad del tratamiento con PF y los cuidados de enfermería que se le proporcionan. Se realizó un estudio retrospectivo, observacional y descriptivo en una muestra de 15 pacientes. Los datos estudiados se han clasificado según el perfil del paciente, parámetros de la PF, evolución del TR, cuidados de enfermería y controles analíticos. Los resultados obtenidos demuestran que el tratamiento con PF es eficaz en el rechazo vascular mediado por anticuerpos ofreciéndose además cuidados integrales al paciente trasplantado, ya que la enfermera de la unidad de TR es la responsable de efectuar la técnica.Plasmapheresis (PPH is a technique that has been applied in the kidney transplant service (KT of our Hospital since 1999, as a treatment in KT that presents vascular rejection. This rejection can be of two types: caused by antibodies or caused by T lymphocytes. Treatment with PPH manages to eliminate the antibodies in the patient's blood, and can therefore be effective when the vascular rejection is caused by antibodies. The technique is carried out by the nurse of the transplant unit. The nurse must be familiar with the technique, the parameters, its indications and the possible complications that may arise. The main purpose of our study is to see the

  15. Impact of mTORC1 Inhibition on Keratinocyte Proliferation During Skin Tumor Promotion in Wild-Type and BK5.AktWT Mice

    OpenAIRE

    Rho, Okkyung; Kiguchi, Kaoru; Jiang, Guiyu; DiGiovanni, John

    2013-01-01

    In this study, we examined the impact of rapamycin on mTORC1 signaling during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced keratinocyte proliferation and skin tumor promotion in both wild-type (FVB/N) and BK5.AktWT mice. TPA activated mTORC1 signaling in a time-dependent manner in cultured primary mouse keratinocytes and a mouse keratinocyte cell line. Early activation (15–30 min) of mTORC1 signaling induced by TPA was mediated in part by PKC activation, whereas later activation (2–4 h)...

  16. Post petroleum

    International Nuclear Information System (INIS)

    In this original book-object, John Urry describes a world conditioned by an all-oil system. Our movement, possessions, and even our social relationships are entirely dependent on this rapidly-depleting energy source. He shows that the 20. century created the illusion of a future that, today, proves untenable, even in the medium term. While everyone's attention is still focused on just how long this reprieve will last, John Urry shifts the debate, asking the much more fundamental question: 'What happens next?' What would a world without oil look like? How would our lives as producers and consumers play out in a world deprived of this resource? In spite of growing awareness of the depletion of oil reserves, these questions remain unanswered. That is why the author alerts us to the need to prepare for post-oil now, and asks: without political awareness, how can our societies radically reinvent their relationship to energy and movement? John Urry thus imagines what will become of 'disconnected' societies in the form of four 'post-oil' scenarios, and calls us to action. His work is of particular importance to the Mobile Lives Forum, which aims to imagine good mobile lives for the future and prepare for the mobility transition. This text is transcript of a lecture given by John Urry to the Mobile Lives Forum's Scientific Steering Committee. Table of contents: 1 - Illusion: Understanding the energization of a social phenomenon; The birth of a new socio-technical system; United states: founders of an all-energy society; The emergence of an oil-based civilisation; Increasing difficulties in the use of oil; The role of oil in the current economic crisis; Can oil-dependency be deleted?; 2 - 4 scenarios: The Magic bullet future; digital lives; Unplugging: a post-car society; Warlordism in a world of shortages; 3 - Conclusion

  17. SUSPICIOUS POST

    CERN Multimedia

    Relations with the Host States Service

    2001-01-01

    If you receive a suspicious letter or package in the post, please do not open it and contact the Fire Brigade Tel. 74444. They will contact the CERN Medical Service. This is especially important in today's current situation with regard to the Anthrax scare. For further information, the Permanent Mission of Switzerland to the International Organisations in Geneva recommends the following web sites:   http://www.admin.ch/ch/f/cf/brennpunkt/03.html http://www.who.int/emc-documents/zoonoses/whoemczdi986c.html

  18. Immunogenicity and protection from malaria infection in BK-SE36 vaccinated volunteers in Uganda is not influenced by HLA-DRB1 alleles.

    Science.gov (United States)

    Tougan, Takahiro; Ito, Kazuya; Palacpac, Nirianne Marie Q; Egwang, Thomas G; Horii, Toshihiro

    2016-10-01

    SE36 antigen, derived from serine repeat antigen 5 (SERA5) of Plasmodium falciparum, is a promising blood stage malaria vaccine candidate. Designated as BK-SE36, the SE36 antigen was formulated with aluminum hydroxyl gel (AHG) and produced under Good Manufacturing Practice (GMP) constraints. In a Phase Ib clinical trial and follow-up study in Uganda, the risk for malaria symptoms was reduced by 72% compared with the control group. Although promising, the number of responders to the vaccine in 6-20years-olds was approximately 30% with the majority in the younger cohort. This is in contrast to the phase Ia clinical trial where response to the vaccine was 100% in Japanese malaria naive adults. A consideration that can be of importance is the involvement of host genetic factors that may influence the ability to mount an effective immune response to vaccination as well as susceptibility to malaria infection. We, therefore, analyzed allelic polymorphism of human leukocyte antigen (HLA)-DRB1 alleles using sequence-based typing (SBT). In this study, DRB1 alleles did not influence antibody response to BK-SE36 and the vaccinees susceptibility to clinical malaria. PMID:27343834

  19. Infección Activa por el Citomegalovirus (CMV) en el trasplante alogénico de precursores hematopoyéticos:Investigación de nuevos factores biológicos para la estimación del riesgo y análisis integral de los mecanismos inmunitarios que la previenen y controlan

    OpenAIRE

    Giménez Quiles, Estela Berenice

    2016-01-01

    Citomegalovirus (CMV) es causa frecuente de morbididad y mortalidad en el marco del trasplante alogénico de precursores hematopoyéticos (alo-TPH). CMV puede ocasionar enfermedad orgánica o tisular (neumonía intersticial o enfermedad gastrointestinal, con mayor frecuencia), en virtud de su “citopatogenicidad” . CMV también puede causar morbididad a través de mecanismos indirectos, relacionados con su capacidad inmunosupresora y pro-inflamatoria; en ese contexto, CMV parece incrementar el ries...

  20. Protocolos clínicos de actuación ante el proceso de donación y extracción de órganos y tejidos para trasplante en donación en muerte encefálica

    OpenAIRE

    J.M. Dueñas Jurado

    2015-01-01

    En el proceso de donación y trasplante de órganos habrá un protocolo de puntos clave para mejorar resultados. La detección de donantes tiene lugar principalmente en las unidades de medicina intensiva (UMI), urgencias y plantas neurológicas. La etiología más frecuente de muerte encefálica (ME) suele ser accidentes cerebrovasculares agudos (ACVA). El mantenimiento del donante es en las UMI. La ME desencadenará cambios fisiopatológicos: inestabilidad hemodinámica, pérdida de respiración espontán...

  1. Factores diagnósticos endoscópicos y pronósticos relacionados con el Helicobacter Pylori en la enfermedad injerto contra huésped tras el trasplante alogénico de células hematopoyéticas

    OpenAIRE

    Velasco Guardado, Antonio

    2015-01-01

    [ES] INTRODUCCIÓN: El trabajo consta de tres artículos originales relacionados por un lado con el diagnóstico endoscópico e histológico en la Enfermedad de Injerto contra Huésped (EICH) tras el trasplante alogénico de células hematopoyéticas (TACH) y por otro sobre el papel que juega la infección por Helicobacter pylori (HP) en dicha enfermedad. El tracto gastrointestinal es la principal diana de la Enfermedad de Injerto contra Huésped. Su diagnóstico se basa en los hallazgos endoscópicos e ...

  2. Large N approach to Kaon decays and mixing 28 years later. ΔI = 1/2 rule, BK, and ΔMK

    International Nuclear Information System (INIS)

    We review and update our results for K → ππ decays and K0- anti K0 mixing obtained by us in the 1980s within an analytic approximate approach based on the dual representation of QCD as a theory of weakly interacting mesons for large N, where N is the number of colors. In our analytic approach the Standard Model dynamics behind the enhancement of ReA0 and suppression of ReA2, the so called ΔI = 1/2 rule for K → ππ decays, has a simple structure: the usual octet enhancement through the long but slow quark - gluon renormalization group evolution down to the scales O(1 GeV) is continued as a short but fast meson evolution down to zero momentum scales at which the factorization of hadronic matrix elements is at work. The inclusion of lowest-lying vector meson contributions in addition to the pseudoscalar ones and of Wilson coefficients in a momentum scheme improves significantly the matching between quark - gluon and meson evolutions. In particular, the anomalous dimension matrix governing the meson evolution exhibits the structure of the known anomalous dimension matrix in the quark - gluon evolution. While this physical picture did not yet emerge from lattice simulations, the recent results on ReA2 and ReA0 from the RBC-UKQCD collaboration give support for its correctness. In particular, the signs of the two main contractions found numerically by these authors follow uniquely from our analytic approach. Though the current - current operators dominate the ΔI = 1/2 rule, working with matching scales O(1 GeV) we find that the presence of QCD-penguin operator Q6 is required to obtain satisfactory result for ReA0. At NLO in 1/N we obtain R = ReA0/ReA2 = 16.0 ± 1.5 which amounts to an order of magnitude enhancement over the strict large N limit value √(2). We also update our results for the parameter BK, finding BK = 0.73 ± 0.02. The smallness of 1/N corrections to the large N value BK = 3/4 results within our approach from an approximate cancelation between

  3. Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA

    DEFF Research Database (Denmark)

    Christensen, S.K.; Pedersen, K.; Hansen, Flemming G.;

    2003-01-01

    Prokaryotic chromosomes encode toxin-antitoxin loci, often in multiple copies. In most cases, the function of these genes is not known. The chpA (mazEF) locus of Escherichia coli has been described as a cell killing module that induces bacterial apoptosis during nutritional stress. However, we...... found recently that ChpAK (MazF) does not confer cell killing but rather, induces a bacteriostatic condition from which the cells could be resuscitated. Results presented here yield a mechanistic explanation for the detrimental effect on cell growth exerted by ChpAK and the homologous ChpBK protein of E....... coli. We show that both proteins inhibit translation by inducing cleavage of translated mRNAs. Consistently, the inhibitory effect of the proteins was counteracted by tmRNA. Amino acid starvation induced strong transcription of chpA that depended on Lon protease but not on ppGpp. Simultaneously, Chp...

  4. Transformation of primary human embryonic kidney cells to anchorage independence by a combination of BK virus DNA and the Harvey-ras oncogene

    International Nuclear Information System (INIS)

    Primary human embryonic kidney (HEK) cells were transformed by a focus assay with BK virus (BKV) DNA molecularly cloned at its unique EcoRI site. Both viral DNA sequences and viral tumor antigens were present and expressed in all the foci that the authors examined. However, cells isolated from foci were incapable of growth in soft agar. They then examined the transformation of HEK cells after their transfection with a combination of BKV DNA and either the normal or the activated form of the human Ha-ras oncogene (EJ c-Ha-ras-1). Only the cells transfected with a combination of BKV DNA and the activated form of Ha-ras DNAs were present in the transformed colonies. BKV tumor antigens and the Ha-ras p21 protein were also expressed

  5. Observation of a resonance-like structure in the pi^+- psi' mass distribution in exclusive B-->K pi^+- psi' decays

    CERN Document Server

    Abe, K; Aihara, H; Arinstein, K; Aso, T; Aulchenko, V; Aushev, T; Aziz, T; Bahinipati, S; Bakich, A M; Balagura, V; Ban, Y; Banerjee, S; Barberio, E; Bay, A; Bedny, I; Belous, K S; Bhardwaj, V; Bitenc, U; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M C; Chang, P; Chao, Y; Chen, A; Chen, K F; Chen, W T; Cheon, B G; Chiang, C C; Chistov, R; Cho, I S; Choi, S K; Choi, Y; Choi, Y K; Cole, S; Dalseno, J; Danilov, M; Das, A; Dash, M; Dragic, J; Drutskoy, A; Eidelman, S; Epifanov, D; Fratina, S; Fujii, H; Fujikawa, M; Gabyshev, N; Garmash, A; Go, A; Gokhroo, G; Goldenzweig, P; Golob, B; Grosse-Perdekamp, M; Guler, H; Ha, H; Haba, J; Hara, K; Hara, T; Hasegawa, Y; Hastings, N C; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Higuchi, T; Hinz, L; Hoedlmoser, H; Hokuue, T; Horii, Y; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hsiung, Y B; Hyun, H J; Igarashi, Y; Iijima, T; Ikado, K; Inami, K; Ishikawa, A; Ishino, H; Itoh, R; Iwabuchi, M; Iwasaki, M; Iwasaki, Y; Jacoby, C; Joshi, N J; Kaga, M; Kah, D H; Kaji, H; Kajiwara, S; Kakuno, H; Kang, J H; Kapusta, P; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Kibayashi, A; Kichimi, H; Kim, H J; Kim, H O; Kim, J H; Kim, S K; Kim, Y J; Kinoshita, K; Korpar, S; Kozakai, Y; Krizan, P; Krokovny, P; Kumar, R; Kurihara, E; Kusaka, A; Kuzmin, A; Kwon, Y J; Lange, J S; Leder, G; Lee, J; Lee, J S; Lee, M J; Lee, S E; Lesiak, T; Li, J; Limosani, A; Lin, S W; Liu, Y; Liventsev, D; MacNaughton, J; Majumder, G; Mandl, F; Marlow, D; Matsumura, T; Matyja, A; McOnie, S; Medvedeva, T; Mikami, Y; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Moloney, G R; Mori, T; Müller, J; Murakami, A; Nagamine, T; Nagasaka, Y; Nakahama, Y; Nakamura, I; Nakano, E; Nakao, M; Nakayama, H; Nakazawa, H; Natkaniec, Z; Neichi, K; Nishida, S; Nishimura, K; Nishio, Y; Nishizawa, I; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, A; Ogawa, S; Ohshima, T; Okuno, S; Olsen, S L; Ono, S; Ostrowicz, W; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, C W; Park, H; Park, K S; Parslow, N; Peak, L S; Pernicka, M; Pestotnik, R; Peters, M; Piilonen, L E; Poluektov, A; Rorie, J; Rózanska, M; Sahoo, H; Sakai, Y; Sakamoto, H; Sakaue, H; Sarangi, T R; Satoyama, N; Sayeed, K; Schietinger, T; Schneider, O; Schonmeier, P; Schümann, J; Schwanda, C; Schwartz, A J; Seidl, R; Sekiya, A; Senyo, K; Sevior, M E; Shang, L; Shapkin, M; Shen, C P; Shibuya, H; Shinomiya, S; Shiu, J G; Shwartz, B; Singh, J B; Sokolov, A; Solovieva, E; Somov, A; Stanic, S; Staric, M; Stypula, J; Sugiyama, A; Sumisawa, K; Sumiyoshi, T; Suzuki, S; Suzuki, S Y; Tajima, O; Takasaki, F; Tamai, K; Tamura, N; Tanaka, M; Taniguchi, N; Taylor, G N; Teramoto, Y; Tikhomirov, I; Trabelsi, K; Tse, Y F; Tsuboyama, T; Uchida, K; Uchida, Y; Uehara, S; Ueno, K; Uglov, T; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Yu; Varner, G; Varvell, K E; Vervink, K; Villa, S; Vinokurova, A; Wang, C C; Wang, C H; Wang, J; Wang, M Z; Wang, P; Wang, X L; Watanabe, M; Watanabe, Y; Wedd, R; Wicht, J; Widhalm, L; Wiechczynski, J; Won, E; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamaoka, M; Yamashita, Y; Yamauchi, M; Yuan, C Z; Yusa, Y; Zhang, C C; Zhang, L M; Zhang, Z P; Zhilich, V; Zhulanov, V; Zupanc, A; Zwahlen, N

    2007-01-01

    A distinct peak is observed in the pi^+/- psi' invariant mass distribution near 4.43 GeV in B->K pi^+/- psi' decays. A fit using a Breit Wigner resonance shape yields a peak mass and width of 4433+-4(stat)+-1(syst) MeV and Gamma = 44^+17_-13(stat) ^+30_-11 MeV. The product branching fraction is determined to be Bf(B-->KZ(4430))xBf(Z(4430)-->pi^+psi') = (4.1+-1.0(stat)+-1.3(syst))x10^{-5), where Z(4430) is used to designate the observed structure. The statistical significance of the observed peak is greater than 7sigma. These results are obtained from a 605 fb-1 data sample that contains 657 million BBbar pairs collected near the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric energy e+e- collider.

  6. Eleven new heaviest isotopes of elements Z=105 to Z=117 identified among the products of 249Bk+48Ca reactions

    International Nuclear Information System (INIS)

    The heaviest isotopes of elements Z=117 to Z=105, 294117, 293117, 290115, 289115, 286113, 285113, 282Rg, 281Rg, 278Mt, 274Bh, and 270Db, were identified by means of the Dubna gas-filled recoil separator among the products of the 249Bk + 48Ca reaction. The details of the observed six decay chains, indicating the production and decay of isotopes 293117 and 294117, are presented and discussed. The decay energies and resulting half-lives of these new nuclei show a strong rise of stability with increasing neutron number, validating the concept of the island of enhanced stability for superheavy nuclei [Oganessian et al., Phys. Rev. Lett. 104, 142502 (2010)].

  7. Impact of preemptive reduction of immunosuppression with serial monitoring for BK virus replication in renal transplant recipients undergoing short-term evaluation.

    Science.gov (United States)

    De Paolis, P; Gervasio, E; Tedesco, M; Favarò, A; Iappelli, M; Abbate, I; Capobianchi, M; Di Giulio, S

    2009-05-01

    The aim of this preliminary, prospective, longitudinal study was to evaluate the effects on graft function and viral loads of modulation of immunosuppressive therapy based upon serial noninvasive monitoring of urine and serum viral loads with real-time polymerase chain reaction among unselected renal transplant recipients. Thirty-nine renal transplant recipients with follow-up times of 7.8 +/- 4.3 months were monitored monthly with urine and serum samples to measure BK viral load. Interventions such as gradual reductions of mycophenolate mofetil and/or tacrolimus were performed when repeated urine and serum viral loads were >10(5) and >10(3) copies/mL, respectively. Among 271 samples, the patients were divided into 6 groups: negative urine (group = 1; n = 10) and negative serum (group 2; n = 25) versus BK viral loads that were intermittent (urine: group 3; n = 24 and serum: group 4; n = 11) versus persistent (urine: group 5; n = 5 and serum: group 6; n = 3). In groups 3-4 we observed the higher viral loads in the urine than in the serum (10(3): 21; 10(4): 1; 10(5): 1; 10(6): 1 vs 10(2): 8; 10(3): 2; 10(4): 1). The timing of resolution of viremia was more rapid than viruria. In groups 5-6 we observed the greatest viral load and greater number in urine. The overall incidences of viruria and viremia were 74.3% and 35.9%, respectively. The overall rates of clearance of viruria were 26/29 recipients (89%) and viremia, 11/14 recipients (78%). Only 10 patients (25.6%) needed extensive reduction of immunosuppression. No modifications of serum creatinine levels and no rejection episodes were observed. In conclusion this preliminary analysis suggested that serial, noninvasive monitoring of viral load allows gradual premptive reduction of immunosuppression with consequent strong reduction in viral load. PMID:19460518

  8. Coordinación y logística del trasplante de tejidos de donantes de cadáver intra y extra-hospitalarios. "Modelo Pamplona": Cadena de actuación 1992-2006 Transplant coordination and logistics of intra and extra-hospital cadaver donor tissue. "The Pamplona Model": Sequence of tasks performed from 1992-2006

    Directory of Open Access Journals (Sweden)

    E. Maraví-Poma

    2006-08-01

    Full Text Available Fundamento. La donación de tejidos y órganos constituye la única alternativa para muchos pacientes. La muerte cerebral (MC facilita esta actitud. Aquellos hospitales no-generadores de donantes con MC, tienen que generar donantes a partir de fallecidos por parada cardiorrespiratoria, llamados donantes de tejidos (DT. En este trabajo se expone el modelo de coordinación y donación de tejidos de DT intra y extra-hospitalarios en la Comunidad Foral de Navarra. Se crea un Programa de detección, donación, extracción, denominado Modelo Pamplona, desde 1992-2006. Material y métodos. A partir de 1990 se organiza el Equipo de Trasplantes formado por un médico de la Unidad de Cuidados Intensivos del hospital Virgen del Camino, Instituto Navarro de Medicina Legal (INML y SOS-Navarra. En 1996 la Coordinación de Trasplantes del HVC es definido como centro de referencia para el Programa de Trasplantes de Tejidos de la Comunidad de Navarra. Resultados. Se desarrollan protocolos consensuados para la detección intra y extrahospitalaria de los fallecidos en parada cardiorrespiratoria: - Alarma desde hospitales del SNS-O, SOS-Navarra, jueces y forenses del INML. - Criterios de selección, búsqueda y contacto con familiares. - Aviso a equipos de serología, extracción y transporte. - Logística y reparto de los tejidos. - Incentivos pactados: económicos, administrativos y normativa al respecto. Conclusiones. El modelo Pamplona, desde el hospital Virgen del Camino resulta positivo y es único en el mundo. La coordinación intra y extrahospitalaria de trasplantes de donantes cadáver desde un hospital de referencia, es un avance científico y organizativo a tener en cuenta para la creación de equipos de extracción y trasplante de tejidos.Introduction. Tissue and organ donations are the only option for many patients. Cerebral death (CD facilitates this approach. However, hospitals that do not provide CD donors have to adapt in order to obtain donors

  9. Post stroke dementia and Post stroke depression

    OpenAIRE

    Trkanjec, Zlatko

    2012-01-01

    Stroke is the rapid loss of brain function due to disturbance in the blood supply to the brain causing predominantly motor and sensory symptoms. However, stroke can cause some other symptoms. Post stroke dementia and depression are probably the most important non-motor consequences of stroke. Post stroke dementia and depression are important and often overlooked symptoms following stroke. Treatment options for Post stroke dementia and depression are still limited, therefore diagnosis of Post ...

  10. Application of a real-time PCR assay to detect BK potassium channel expression in samples from Atlantic salmon (Salmo salar and Rainbow trout (Oncorhynchus mykiss acclimated to freshwater#

    Directory of Open Access Journals (Sweden)

    CA Loncoman

    2015-01-01

    Full Text Available Atlantic salmon (Salmo salar and Rainbow trout (Oncorhynchus mykiss are two fish species that spawn in fresh water (FW and, during development, acclimate to seawater (SW by secreting excess NaCl to the environment. The salmon industry measures Na+/K+ ATPase (NKA activity as a molecular marker to determine the timing of smolt transfer from FW to SW. However, the lack of other accurate molecular markers of smoltification remains a major issue for the fish farming industry. The molecular mechanism of NaCl secretion in gills from SW-acclimated fish has a thermodynamic requirement to recycle K+ out of the cell via potassium channels therefore we hypothesised that potassium channel expression in gills may be a suitable candidate to monitor the smoltification process. In support of this hypothesis, we observed increased expression of BK potassium channel mRNA in gills from S. salar under conditions of high salinity (1.2% compared to animals in FW. In this work, we designed a real-time PCR analysis in order to quantify mRNA levels of BK potassium channels in S. salar organ samples. We found differences in mRNA expression among gills, kidney and intestine. We also found a unique real-time PCR product in S. salar gills through melting curve analysis, agarose gel electrophoresis and cDNA sequencing. This PCR product showed a 98% of identity with the BK channel portion recorded by the NCBI Database and was differentially expressed in gills, kidney and intestine. This real-time PCR assay may become an important tool to study BK potassium channels expressed in the gills of S. salar and its changes during smoltification as putative new candidate to monitor this process.

  11. Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel

    Science.gov (United States)

    Carrasquel-Ursulaez, Willy; Contreras, Gustavo F.; Sepúlveda, Romina V.; Aguayo, Daniel; González-Nilo, Fernando

    2015-01-01

    Large-conductance Ca2+- and voltage-activated K+ channel (BK) open probability is enhanced by depolarization, increasing Ca2+ concentration, or both. These stimuli activate modular voltage and Ca2+ sensors that are allosterically coupled to channel gating. Here, we report a point mutation of a phenylalanine (F380A) in the S6 transmembrane helix that, in the absence of internal Ca2+, profoundly hinders channel opening while showing only minor effects on the voltage sensor active–resting equilibrium. Interpretation of these results using an allosteric model suggests that the F380A mutation greatly increases the free energy difference between open and closed states and uncouples Ca2+ binding from voltage sensor activation and voltage sensor activation from channel opening. However, the presence of a bulky and more hydrophobic amino acid in the F380 position (F380W) increases the intrinsic open–closed equilibrium, weakening the coupling between both sensors with the pore domain. Based on these functional experiments and molecular dynamics simulations, we propose that F380 interacts with another S6 hydrophobic residue (L377) in contiguous subunits. This pair forms a hydrophobic ring important in determining the open–closed equilibrium and, like an integration node, participates in the communication between sensors and between the sensors and pore. Moreover, because of its effects on open probabilities, the F380A mutant can be used for detailed voltage sensor experiments in the presence of permeant cations. PMID:25548136

  12. Identification of B-K near edge x-ray absorption fine structure peaks of boron nitride thin films prepared by sputtering deposition

    International Nuclear Information System (INIS)

    Four π* resonance peaks were observed in the B-K near edge x-ray absorption fine structure spectra of boron nitride thin films prepared by magnetron sputtering. In the past, these peaks have been explained as the K-absorption of boron atoms, which are present in environment containing nitrogen vacancies, the number of which is 1-3 corresponding to the three peaks at higher photon energy. However, the authors found that there was a strong correlation between the intensities of these three peaks and that of O-K absorption after wide range scanning and simultaneous measurement of nitrogen and oxygen K-absorptions of the BN films. Therefore, the authors conclude that these three peaks at the higher energy side correspond to boron atoms bound to one-to-three oxygen atoms instead of three nitrogen atoms surrounding the boron atom in the h-BN structure. The result of the first-principles calculation with a simple cluster model supported the validity of this explanation.

  13. USO DE MEDICAMENTOS INMUNOSUPRESORES EN PACIENTES CON TRASPLANTE RENAL, HEPÁTICO Y DE MÉDULA ÓSEA, EN UNA CLÍNICA DE NIVEL III DE BOGOTÁ Use of immunosuppressive drugs in patients with kidney, liver or bone marrow transplant in a high complexity clinic in Bogotá, Colombia

    Directory of Open Access Journals (Sweden)

    Jorge J López G

    2009-01-01

    Full Text Available Antecedentes. El trasplante de órganos en la actualidad es una opción terapéutica para los pacientes que cursan estadíos terminales de ciertas patologías; el uso de inmunosupresores contribuye en gran medida a la efectividad de este tipo de tratamientos, ya que es fundamental para evitar el rechazo. El no seguimiento del consumo de medicamentos nuevos, como es el caso de los inmunosupresores que suelen tener precios relativamente elevados, junto con la ampliación injustificada de indicaciones, puede ocasionar un aumento de los costos de la terapia farmacológica y, lo más importante, causar riesgos en el paciente trasplantado. Objetivos. Describir y caracterizar el uso de medicamentos inmunosupresores en pacientes con trasplante renal, de médula ósea alogénico y hepático. Material y métodos. Estudio observacional-descriptivo de corte transversal con recolección retrospectiva de la información a un año. Se trata de un estudio de utilización de medicamentos sobre hábitos de prescripción. Resultados. El desenlace global de la terapia del trasplante produce resultados satisfactorios en un 92,5 por ciento (49 pacientes, 5,7 por ciento (3 pacientes presentan rechazo con retiro del injerto, mientras que un paciente fallece después de ser sometido al trasplante. El medicamento más prescrito es el micofenolato de mofetil, con 41 prescripciones (28%, mientras que el más consumido es la prednisona con 2,38 dosis diaria definidas /100 pacientes/día. Conclusiones. Se evidencia la presencia de micofenolato, ciclosporina y corticoides en la mayoría de los esquemas con algunas prescripciones de anticuerpos monoclonales y globulina antitimocítica.Background. Organ transplantation is currently a therapeutic option for patients at the terminal stages of diverse pathologies. The use of immunosuppressants greatly contributes to the efficacy of these treatments by preventing organ rejection. The lack of follow-up to the use of new medications

  14. Aspectos sócio-políticos da implantação da Central de Transplantes do Piauí Aspectos socio-políticos de la implantación de la Central de Trasplantes de Piauí Socio-political aspects of the implantation of the Transplant Center of Piauí

    Directory of Open Access Journals (Sweden)

    Adélia Dalva da Silva Oliveira

    2007-08-01

    Full Text Available Estudo qualitativo objetivando compreender os aspectos sócio-políticos que mediaram a implantação da central de transplante do Piauí, identificar os sujeitos sociais envolvidos nessa implantação e analisar a participação da sociedade civil organizada. Fizeram parte do estudo dez sujeitos diretamente relacionados com a implantação da central, sendo delimitados por meio da técnica de "bola-de-neve". Utilizou-se a entrevista semi-estruturada, gravada, transcrita e submetida à análise temática. Concluiu-se que, a implantação da central de transplante no Piauí, foi fruto de um complexo jogo de negociações e interesses entre Estado e sociedade civil organizada, já que não havia um projeto político para ações na área dos transplantes. Esse distanciamento da responsabilidade da Gestão Pública caracteriza a importância que foi dada a essa implantação.El presente documento es un Estudio cualitativo objetivando comprender los aspectos sociopolíticos que mediaron en la implantación de la Central de Trasplante de Piauí, se propone identificar los sujetos sociales involucrados en esa implantación y analizar la participación de la sociedad civil organizada. Hicieron parte del estudio diez sujetos directamente relacionados con la implantación de la central de trasplante, siendo delimitados a través de la técnica de "bola-de-nieve". Se utilizó la entrevista semi-estructurada, grabada, transcrita y sometida al análisis temático. Se concluyó que la implantación de la central de trasplante en Piauí, fue fruto de un complejo juego de negociaciones e intereses entre el Estado y la sociedad civil organizada, ya que no había un proyecto político para acciones en el área de los trasplantes. Ese distanciamiento de la responsabilidad de la Gestión Pública caracteriza la importancia que fue dada a esa implantación.A qualitative study aiming at understanding the socio-political aspects that mediate the implantation of the

  15. Post-Adolescent Issues

    Science.gov (United States)

    Search COPING & HEALING CARING FOR A CHILD: POST-ADOLESCENT ISSUES As your child reaches adulthood, there will ... intake. New issues that you and your post adolescent child may want to discus together with his/ ...

  16. Disfunción hepática en el trasplante de células progenitoras hematopoyéticas. Impacto sobre la mortalidad Liver dysfunction in recipients of hematopoietic stem cells. Impact on mortality

    Directory of Open Access Journals (Sweden)

    Daniel Cocozzella

    2005-04-01

    Full Text Available El compromiso hepático en receptores de trasplante alogénico de células progenitoras hematopoyéticas (TCPH es una complicación muy frecuente y es responsable de la morbimortalidad precoz. La toxicidad por fármacos, la enfermedad injerto versus huésped (EICH, la enfermedad venooclusiva (EVO y las infecciones fúngicas, bacterianas y virales constituyen las principales etiologías. El objetivo de este estudio retrospectivo fue establecer la prevalencia y etiología de la afectación hepática, evaluar el impacto en la mortalidad y analizar el valor predictivo de las transaminasas pre TCPH en la ocurrencia de EICH agudo, crónico y mortalidad. De un total de 236 pacientes trasplantados, se evaluaron 82 sometidos a TCPH alogénico. El 88% de los pacientes tuvo afectación hepática: EICH agudo 40.2%, EICH crónico 15.9%, de causa indeterminada 9.8%, sepsis 7.3%, toxicidad por fármacos 6.1%, EVO 3.7%, hepatitis aguda y recidiva de enfermedad 2.4%. La mortalidad evaluada al año fue 36.6%. La insuficiencia hepática aguda (IHA representó el 10% de las muertes. Las causas de IHA fueron: progresión de EICH agudo, recidiva de la enfermedad hematológica en el hígado, hepatitis herpética y EVO. El valor predictivo positivo de las transaminasas pre TCPH para EICH agudo, crónico y mortalidad fue 0.27, 0.14 y 0.43 respectivamente. No se hallaron diferencias significativas entre pacientes con pruebas bioquímicas hepaticas pre TCPH alteradas o normales en la ocurrencia de EICH agudo, crónico o mortalidad.Liver disease is a well-known cause of early morbidity and mortality affecting 80% of patients receiving allogeneic bone-marrow transplantation (BMT. Drug toxicity, veno-occlusive disease (VOD, acute graft-versus-host disease (GVHD, and fungal, bacterial, and viral infections are the most frequent hepatic complications during this period. The aim of this retrospective study was to determine the prevalence and etiology of liver disease and its

  17. Efectos de la glutamina parenteral en pacientes sometidos a trasplante de médula ósea Effects of parenteral glutamine in patients submitted to bone marrow transplantation

    Directory of Open Access Journals (Sweden)

    C. Gómez Candela

    2006-02-01

    Full Text Available El Trasplante de Médula Ósea (TMO, es un tratamiento utilizado en las neoplasias malignas hematológicas y tumores sólidos. La quimioterapia y/o radioterapia asociadas a que están sometidos estos pacientes, induce efectos secundarios, con un alto estrés metabólico. La glutamina es considerada como un aminoácido condicionalmente esencial y se ha mostrado eficaz en estados catabólicos severos. El objetivo del estudio fue valorar el efecto del tratamiento con Nutrición Parenteral (NP suplementada con glutamina sobre la duraci��n del soporte nutricional en un grupo de pacientes con TMO. También han sido analizadas las complicaciones asociadas, valoración del estado nutricional, evolución clínica a los 6 meses, diferencias en el tipo de transplante y capacidad de ingesta oral. Se trata de un Ensayo Clínico en fase IV, aleatorizado, doble ciego, paralelo y unicéntrico. El Estudio se realizó en 49 pacientes, 29% varones y 71% mujeres, con edades comprendidas entre 21-63 años, distribuidos en tres grupos diagnósticos (leucemias, linfomas y tumores sólidos, ingresados en el Servicio de Hematología de nuestro Hospital. El 50% de pacientes en cada grupo han recibido NP suplementada con glutamina (0,4 g/kg/día de L-alanil-L-glutamina y otro 50% han recibido NP Estándar. RESULTADOS: No se han encontrado diferencias significativas, ni al inicio ni al final del estudio entre ambos grupos, en relación con las variables estudiadas. CONCLUSIONES: La NP es un tratamiento efectivo para el mantenimiento del estado nutricional, en los pacientes sometidos a una terapia con efecto altamente catabólico, como es el TMO. Aunque no hemos podido demostrar la eficacia de la suplementación con glutamina en este estudio con la dosis de glutamina utilizada, sí ha resultado ser eficaz en otras publicaciones.Bone marrow transplantation (BMT is a therapy used for hematologic malignancies and solid tumors. Associated chemotherapy and radiotherapy to

  18. Percepción de la calidad de vida por enfermos sometidos a tratamientos de hemodiálisis o trasplante renal: Estudio comparativo Perception of the quality of life of patients undergoing haemodialysis or kidney transplant: A comparative study

    Directory of Open Access Journals (Sweden)

    Gerardo Borroto Díaz

    2007-09-01

    Full Text Available Se sabe que los pacientes afectos de enfermedad renal crónica terminal sometidos a hemodiálisis (HD o trasplante renal (TR tienen un deterioro importante de su calidad de vida (CV, no obstante, el implante de un nuevo riñón normalmente funcionante se acompaña de una mejor percepción de la CV y, por ende, un mayor ajuste al tratamiento. Se realizó un estudio para comparar la percepción de la CV en 2 grupos de pacientes: uno bajo tratamiento de HD (GI = 20 enfermos y otro de TR (G2 =32 pacientes que cumplieran los criterios de inclusión establecidos, para corroborar la anterior aseveración. Se les aplicó una encuesta con parámetros generales, clínicos y psicológicos. El equipo de atención a estos enfermos hizo una valoración cuantitativa de la misma. Se halló que: los pacientes con TR tenían buena percepción de su CV, superior al compararla con la de los enfermos tratados con HD; las mujeres, los jóvenes y el nivel de escolaridad medio constituyeron los grupos de enfermos con mejor aceptación de su enfermedad y del tratamiento aplicado, mientras que el tiempo prolongado de HD, los niveles bajos de albúmina, hemoglobina y la alta tasa de hospitalización se correlacionaron negativamente con la percepción de su CV, las mayores preocupaciones de estos enfermos se centraban en el apoyo y las relaciones familiares, le siguieron en importancia, la esfera sexual y la reincorporación laboral.It is known that those patients suffering from end-stage chronic renal disease that undergo haemodialysis (HD or renal transplant (RT experience a significant deterioration of their quality of life; however, the implant of a new kidney that works normally leads to a better perception of the quality of life and, therefore, to a better adjustment to the treatment. A study was conducted to compare the perception of the quality of life in 2 groups of patients: one under haemodialysis treatment (G1 = 20 patients, and the other with renal transplant

  19. Prediction of post-post-perovskite transitions

    Science.gov (United States)

    Umemoto, K.

    2008-12-01

    In the Earth, the post-perovskite structure is the final form of MgSiO3. However, in the solar giants and exoplanets in which pressure is much higher than the Earth, we can expect further phase transitions beyond the post-perovskite phase, i.e., post-post-perovskite transitions. Here we propose by first principles two candidates of crystalline post-post-perovskite phases of NaMgF3, which is a low-pressure analog of MgSiO3: U2S3-type and P63/mmc phases. Then we demonstrate that Al2O3 should undergo a transition to the U2S3-type phase at ~3.7 Mbar. This transformation should be important for the analysis of shock data in this pressure range, since alumina is used as window material. Our calculated compression curves agree with shock data excellently, suggesting the presence of two phase transitions (corundum-to-Rh2O3(II)-type and Rh2O3(II)-type-to-CaIrO3-type) in shock data. Our prediction also suggests that the multi-Mbar crystal chemistry of planet-forming minerals might be related to that of the rare-earth sulfides. Computations were performed at the Minnesota Supercomputing Institute. Research was supported by NSF grants EAR-0135533, EAR-0230319, and ITR-0428774 (VLab).

  20. Glove box posting system

    International Nuclear Information System (INIS)

    A system for posting objects into closed containers, such as glove boxes, is described in which the bag used, preferably made of plastic, does not have to be fitted and sealed by the operator during each posting operation. (U.K.)

  1. Alterações fisiológicas da morte encefálica em potenciais doadores de órgãos e tecidos para transplantes Los cambios fisiológicos de la muerte cerebral en potenciales donadores de órganos y tejidos para trasplante Physiological changes of brain death in potential donors of organs and tissues for transplantation

    Directory of Open Access Journals (Sweden)

    Sarah Gabriel Freire

    2012-12-01

    Full Text Available Objetivou-se descrever as alterações fisiológicas da morte encefálica em potenciais doadores de órgãos e tecidos para transplantes. Estudo exploratório descritivo com dados prospectivos e abordagem quantitativa realizado nas unidades de emergência e terapia intensiva adulto de um hospital de Pernambuco no período de abril a outubro de 2011. A população constou de 32 potenciais doadores de órgãos e tecidos para transplantes. Após aprovação do Comitê de Ética em Pesquisa, os dados foram coletados, tabulados e analisados pela estatística descritiva pelo software SPSS 15.0 e apresentados em forma de tabelas. As alterações fisiológicas foram: hipotensão arterial (100%, hipotermia (75,0%, hipernatremia (62,5%, diabetes insipidus (37,5%, hiperglicemia (32,3%, infecção (25,0%, hipertensão arterial (9,4% e úlcera de córnea (3,1%. Acredita-se que o conhecimento dessas alterações possibilita à equipe de saúde direcionar o cuidado ao potencial doador segundo as suas necessidades e, assim, manter o órgão/tecido viável para transplante.El objetivo del estudio fue describir los cambios fisiológicos de la muerte cerebral en los potenciales donadores de órganos y tejidos para trasplante. Investigación exploratoria, descriptiva, con datos prospectivos y enfoque cuantitativo, hecho en las unidades de emergencia y de cuidados intensivos de adultos de un hospital de Pernambuco en el periodo de abril a octubre de 2011. La población fue formada por 32 potenciales donadores de órganos y tejidos para trasplante. Después de la aprobación en el Comité Ético de Investigación, los datos han sido recogidos, tabulados y analizados mediante estadística descriptiva por el programa informático SPSS 15.0, siendo presentados en forma de tablas. Los cambios fisiológicos fueron: hipotensión (100%, hipotermia (75,0%, hipernatremia (62,5%, diabetes insípida (37,5%, infección (25,0%, hipertensión arterial (9,4% y la úlcera de c

  2. Resultados de una encuesta sobre donación y trasplante de órganos en la zona metropolitana de Guadalajara, México Survey results regarding organ donation and transplant in metropolitan Guadalajara, Mexico

    Directory of Open Access Journals (Sweden)

    Luz Consuelo Zepeda-Romero

    2003-01-01

    Full Text Available OBJETIVO: Evaluar el conocimiento y la disposición de la donación de órganos y tejidos con fines de trasplante entre la población adulta del área metropolitana de Guadalajara, Jalisco, México. MATERIAL Y MÉTODOS: Se realizó una encuesta aplicando un cuestionario de 29 reactivos a personas mayores de 18 años de edad, mediante entrevista directa en la vía pública. La zona metropolitana se dividió en cuatro municipios, asignándose a cada uno de éstos el número de encuestas en proporción al número de habitantes, estrato socioeconómico, edad y género. Se calcularon frecuencias y ji2 para diferencias de proporciones. RESULTADOS: Se encuestaron 400 individuos. El 80.4% conocía acerca de la donación de órganos y 65% sabía que está permitido por la ley; sin embargo, solamente 24% había comentado el tema en familia. El 71% de los encuestados desconocía cómo donar sus órganos y sólo 25% sabía de la existencia de la tarjeta de donación. Por otra parte, 66% estarían dispuestos a donarlos, 16.5% no lo harían y 17% estaban indecisos. La mutilación corporal fue la razón principal (40% para no donar. El 89% estarían dispuestos a autorizar la extracción de órganos de un familiar, siempre que éste hubiera manifestado su deseo en vida; de lo contrario, sólo 29% procederían con la autorización. Finalmente, 65% consideró la licencia de conducir como un medio adecuado de expresar el deseo de donar y 50% considera insuficiente la información que sobre el tema se ha difundido por los medios de comunicación. CONCLUSIONES: La mayoría de la población de la zona metropolitana de la ciudad de Guadalajara tiene conocimiento sobre la donación de órganos y estaría dispuesta a donarlos. Sin embargo, un alto porcentaje desconoce el cómo hacerlo y considera insuficiente la información difundida sobre el tema. Una campaña permanente a través de los medios de comunicación masiva podría solucionar lo anterior e incrementaría la

  3. Pérdida de glutatión desde pulmones de conejo en solución de preservación para trasplante: Efectos clínicos y funcionales a corto plazo Loss of glutathione from rabbit lungs in transplant preservation solution

    Directory of Open Access Journals (Sweden)

    MARíA E SOLOVERA R

    2009-01-01

    Full Text Available El daño por isquemia-reperfusión es causa de morbimortalidad en pacientes con trasplante pulmonar. Se desconoce si la solución de preservación habitual del pulmón puede contribuir a la deficiencia de antioxidantes, favoreciendo el estrés oxidativo en el receptor. Objetivo: Evaluar si existe pérdida de glutatión desde pulmones de conejo a la solución de preservación para trasplante. Resultados: Encontramos una disminución en el contenido de glutatión total del pulmón, sin aumento en el contenido de glutatión oxidado. Esto se asoció a la aparición y aumento sostenido de glutatión en la solución de preservación desde los 30 min. Conclusiones: Existe salida de glutatión desde el pulmón no mediada por oxidación de éste y posiblemente favorecida por el gradiente de concentración de glutatión reducido. Esta pérdida deja al tejido vulnerable frente a las condiciones de estrés oxidativo en el receptor.Introduction: Ischemia-reperfusion injury causes morbidity and mortality in lung transplant patients. It is unknown if the usual lung preservation solution favors antioxidant deficiency and thus, increased oxidative stress in the receptor. Objective: To evaluate if there is any loss of glutathione from rabbit lungs to the preservation solution. Results: We found a decrease in lung total glutathione content, without an increase in the oxidized form of this antioxidant. At the same time, we were able to measure increasing levels of glutathione in the preservation solution from 30 min on. Conclusions: There is loss of glutathione from the lung to the preservation solution that is not mediated by glutathione oxidation and likely due to passage of the reduced form along the concentration gradient, rendering the tissue vulnerable to oxidative stress once in the receptor.

  4. Cloning, expression in Pichia pastoris, and characterization of a thermostable GH5 mannan endo-1,4-β-mannosidase from Aspergillus niger BK01

    Directory of Open Access Journals (Sweden)

    Sigoillot Jean-Claude

    2009-11-01

    Full Text Available Abstract Background Mannans are key components of lignocellulose present in the hemicellulosic fraction of plant primary cell walls. Mannan endo-1,4-β-mannosidases (1,4-β-D-mannanases catalyze the random hydrolysis of β-1,4-mannosidic linkages in the main chain of β-mannans. Biodegradation of β-mannans by the action of thermostable mannan endo-1,4-β-mannosidase offers significant technical advantages in biotechnological industrial applications, i.e. delignification of kraft pulps or the pretreatment of lignocellulosic biomass rich in mannan for the production of second generation biofuels, as well as for applications in oil and gas well stimulation, extraction of vegetable oils and coffee beans, and the production of value-added products such as prebiotic manno-oligosaccharides (MOS. Results A gene encoding mannan endo-1,4-β-mannosidase or 1,4-β-D-mannan mannanohydrolase (E.C. 3.2.1.78, commonly termed β-mannanase, from Aspergillus niger BK01, which belongs to glycosyl hydrolase family 5 (GH5, was cloned and successfully expressed heterologously (up to 243 μg of active recombinant protein per mL in Pichia pastoris. The enzyme was secreted by P. pastoris and could be collected from the culture supernatant. The purified enzyme appeared glycosylated as a single band on SDS-PAGE with a molecular mass of approximately 53 kDa. The recombinant β-mannanase is highly thermostable with a half-life time of approximately 56 h at 70°C and pH 4.0. The optimal temperature (10-min assay and pH value for activity are 80°C and pH 4.5, respectively. The enzyme is not only active towards structurally different mannans but also exhibits low activity towards birchwood xylan. Apparent Km values of the enzyme for konjac glucomannan (low viscosity, locust bean gum galactomannan, carob galactomannan (low viscosity, and 1,4-β-D-mannan (from carob are 0.6 mg mL-1, 2.0 mg mL-1, 2.2 mg mL-1 and 1.5 mg mL-1, respectively, while the kcat values for these

  5. Post-Inflammatory Hyperpigmentation

    Science.gov (United States)

    ... rash and rashes clinical tools newsletter | contact Share | Post-Inflammatory Hyperpigmentation Information for adults A A A ... 2006-2013 Logical Images, Inc. All rights reserved. Advertising Notice This Site and third parties who place ...

  6. Post-Inflammatory Hypopigmentation

    Science.gov (United States)

    ... rash and rashes clinical tools newsletter | contact Share | Post-Inflammatory Hypopigmentation Information for adults A A A ... 2006-2013 Logical Images, Inc. All rights reserved. Advertising Notice This Site and third parties who place ...

  7. Post-Approval Studies

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CDRH Post-Approval Studies Program encompasses design, tracking, oversight, and review responsibilities for studies mandated as a condition of approval of a...

  8. Transplante cardíaco (TC: a experiência do portador da doença de Chagas Trasplante cardíaco (TC: la experiencia del portador de la enfermedad de Chagas Heart transplantation: the experience of patients with Chagas disease

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Araújo Sadala

    2009-09-01

    Full Text Available O sucesso do transplante cardíaco com portadores da doença de Chagas está condicionado a cuidados especiais durante todas as fases do transplante, com necessidade de acompanhamento específico e rigoroso pela equipe de saúde. Os receptores devem estar conscientes da permanência do Trypanossoma no organismo, e das possibilidades de reativação da infecção após o transplante. Portanto, seu conhecimento dessa condição, e a sua participação ativa no próprio tratamento, têm importância fundamental. O objetivo do estudo foi investigar a experiência do transplante cardíaco vivenciada por pacientes portadores da doença de Chagas, para buscar compreender os significados que eles atribuem a esta experiência. Os procedimentos metodológicos abrangeram: a seleção dos pacientes; as entrevistas; a análise dos dados, indicando as unidades de significado e a análise individual; a busca de convergências dos discursos; e análise hermenêutica das convergências. Da análise dos dados emergiram os seguintes temas: o tempo vivido pelo receptor, portador da Doença de Chagas; a concepção do TC apresentado pelo portador de Chagas; o cuidado na trajetória do TC.El éxito del trasplante cardíaco con portadores de la enfermedad de Chagas está condicionado a cuidados especiales durante todas las fases del trasplante, con necesidad de acompañamiento específico y riguroso por el equipo de salud. Los receptores deben estar conscientes de la permanencia del Tripanosoma en el organismo y de las posibilidades de reactivación de la infección después del trasplante. Por lo tanto, su conocimiento sobre esa condición y su participación activa en el propio tratamiento es de fundamental importancia. El objetivo del estudio fue investigar la experiencia del trasplante cardíaco experimentada por pacientes portadores de la enfermedad de Chagas, para comprender los significados que ellos atribuyen a esta experiencia. Los procedimientos metodol

  9. Transplante cardíaco: complicações apresentadas por pacientes durante a internação Trasplante de corazón: complicaciones que presentan los pacientes durante la hospitalización Heart Transplantation: complications presented by patients during the hospitalization

    Directory of Open Access Journals (Sweden)

    Elaine Araújo da Silva

    2012-12-01

    Full Text Available Com o avanço da ciência, a insuficiência cardíaca tem como possibilidade de intervenção o transplante cardíaco. Este trabalho teve como objetivos traçar o perfil demográfico dos pacientes submetidos ao transplante cardíaco e identificar as complicações apresentadas durante a internação. Trata-se de um estudo descritivo, quantitativo, realizado com 44 prontuários de pacientes submetidos a transplante de junho/2006 a julho/2009 em um Hospital Universitário de Belo Horizonte, Minas Gerais, Brasil. O projeto atendeu às recomendações da Resolução 196/96. Pelos resultados, a maioria dos pacientes era do sexo masculino, casada, escolaridade de nível fundamental e idade média de 45,2 anos. A miocardiopatia chagásica foi a principal causa de insuficiência cardíaca. As complicações predominantes foram alteração da glicemia, insuficiência renal e infecções. A taxa de mortalidade na internação foi de 20,4%. Além das complicações biológicas só foram registradas ansiedade e depressão. São necessárias pesquisas sobre o tema nos âmbitos psicossociais e espirituais, contribuindo para o desenvolvimento científico.Hoy día, con los avances de la medicina y de la tecnología para el tratamiento de la insuficiencia cardiaca irreversible, se ha utilizado como última intervención el trasplante cardíaco. Este trabajo se desarrolló con los objetivos de delinear el perfil demográfico de los pacientes sometidos a trasplante cardíaco e identificar las complicaciones presentadas por ellos después del trasplante de corazón. Estudio descriptivo y cuantitativo, realizado en conjunto con los registros de 44 pacientes sometidos a trasplante de corazón desde Jun/2006 hasta Jul/2009, en un Hospital Universitario de Belo Horizonte, Minas Gerais, Brasil. El proyecto cumplió con las recomendaciones de la Resolución 196/96. Los resultados mostraron que la mayoría de los pacientes eran del sexo masculino, casados, con educaci

  10. Computer Security: posting and mis-posting

    CERN Document Server

    Stefan Lueders, Computer Security Team

    2015-01-01

    This is what can happen at CERN if you don't lock your computer screen...   “Hi, I am looking for a partner either male or female to attend salsa lessons. I have a great body and enjoy rubbing it against other people on the dance floor. I would consider dinner after with the right person. If you think you can keep up with me and enjoy getting sweaty send me a reply. Stay sexy…” This is the original text of a recent posting on the CERN Market webpage. Some people might find this appealing, some people think this is funny. Personally, I couldn’t care less. But professionally, we had to follow up as this text can be perceived as inappropriate and, thus, in violation of the Terms of Usage of the CERN Market as well as the CERN Computing Rules and its annex on private usage of the CERN computing facilities. We remind you that the CERN Market is a public website that can be used by people within but also outside CERN. All posts are visible world...

  11. Post-Session Authentication

    DEFF Research Database (Denmark)

    Ahmed, Naveed; Jensen, Christian D.

    2012-01-01

    Entity authentication provides confidence in the claimed identity of a peer entity, but the manner in which this goal is achieved results in different types of authentication. An important factor in this regard is the order between authentication and the execution of the associated session. In this...... paper, we consider the case of post-session authentication, where parties authenticate each other at the end of their interactive session. This use of authentication is different from session-less authentication (e.g., in RFID) and pre-session authentication (e.g., for access control.) Post......-session authentication, although a new term, is not a new concept; it is the basis of at least a few practical schemes. We, for the first time, systematically study it and present the underlying authentication model. Further, we show that an important class of problems is solvable using post-session authentication as...

  12. Post-partum pancreatitis.

    Directory of Open Access Journals (Sweden)

    Pai P

    1993-04-01

    Full Text Available Acute pancreatitis in pregnancy and post-partum period, rarely encountered in surgical practice, can have a lethal effect on the mother and the foetus. We report here a case of a 35 year old tertigravida who presented with high grade fever, abdominal pain with distension, tachycardia and tachypnoea. Chest examination and X-rays were suggestive of pneumonia. The abdomen was tense and tender. Peristalsis was absent. Ultrasound revealed presence of fluid in the abdominal cavity which on paracentesis was found to contain Gram positive cocci. Fluid amylase levels were high. On exploratory laparotomy, haemorrhagic oedematous pancreatitis was noticed. The patient expired on the 2nd post operative day.

  13. Pornografinio turinio produkcijos gaminimas, platinimas ir viešas demonstravimas. Atsakomybė už tai LR BK ir kitų valstybių įstatymuose

    OpenAIRE

    Supranavičiūtė, Joana

    2011-01-01

    Lietuvos Respublikos Baudžiamojo kodekso 309 straipsnis “Disponavimas pornografinio turinio dalykais“ nustato baudžiamąją atsakomybę už pornografijos gaminimą, platinimą, reklamavimą ir viešą demonstravimą. Straipsnis skiria pornografiją į pilnamečių asmenų ir vaikų pornografiją. Nors ši veika yra kriminalizuota, praktikoje LR BK 309 straipsnis taikomas retai dėl keblumų, kylančių internetinėje erdvėje – fiziniai ir juridiniai asmenys gali lengvai išvengti baudžiamosios atsakomybės. Atsižv...

  14. Teaching Post Keynesian Economics

    DEFF Research Database (Denmark)

    Denne bog har gør gældende, at post keynesiansk økonomi har sit egen metodiske og didaktiske grundlag, og dens realistisk analyse er tiltrængt i den aktuelle økonomiske og finansielle krise. På et tidspunkt hvor det oprindelige indhold i Keynes 'General Theory ikke længere er til stede i de flest...

  15. Teaching Post Keynesian Economics

    DEFF Research Database (Denmark)

    Madsen, Poul Thøis

    2013-01-01

    Denne bog har gør gældende, at post keynesiansk økonomi har sit egen metodiske og didaktiske grundlag, og dens realistisk analyse er tiltrængt i den aktuelle økonomiske og finansielle krise. På et tidspunkt hvor det oprindelige indhold i Keynes 'General Theory ikke længere er til stede i de flest...

  16. Post-keratoplasty glaucoma

    Directory of Open Access Journals (Sweden)

    S. A. Malozhen

    2015-10-01

    Full Text Available Post-keratoplasty glaucoma (PKG remains one of the leading causes of blindness due to the loss of optic nerve fibers and irreversible graft opacification. PKG is a challenge due to diagnostic and therapeutic difficulties and recalcitrant course. This paper reviews main pre-operative PKG risk factors such as pre-existing glaucoma, corneal disorders for which keratoplasty is performed, and lens status. Intraoperative errors that caused by ocular hypertension (tight suturing, larger trephine sizes, long bites of individual sutures, increased peripheral corneal thickness and graft-host disparity are evaluated. Peripheral anterior synechiae, steroid use, and tonometry errors after deep anterior lamellar keraplasty are amongst post-operative causes of PKG. Partial transparency optical media, high post-operative astigmatism and graft edema make standard tonometry unreliable. Various tonometers and measurement reliability after keratoplasty are discussed. Currently, multiple treatment options including medications, laser and filtering surgery, glaucoma drainage devices and cyclodestructive procedures are available. In most cases of PKG, medications are initially prescribed. Evolution of approaches to PKG treatment as well as current therapy schedules, their advantages and ophthalmic complications are discussed. In cases non-responsive to medications, laser trabeculoplasty is performed. If laser procedures cannot be performed of their hypotensive effect is insufficient, glaucoma surgery is advised. A number of specialists prefer trabeculectomy with intra- or post-operative cytostatic adjunct. Glaucoma surgery with various drainage device implantation prevails. Ineffective surgery can be enhanced with transscleral laser cyclophotocoagulation.

  17. Post-irradiation diarrhea

    International Nuclear Information System (INIS)

    In radiotherapy of pelvic cancers, the X-ray dose to be delivered to the tumour is limited by the tolerance of healthy surrounding tissue. In recent years, a number of serious complications of irradiation of pelvic organs were encountered. Modern radiotherapy necessitates the acceptance of a calculated risk of complications in order to achieve a better cure rate. To calculate these risks, one has to know the radiation dose-effect relationship of normal tissues. Of the normal tissues most at risk when treating pelvic tumours only the bowel is studied. In the literature regarding post-irradiation bowel complications, severe and mild complications are often mixed. In the present investigation the author concentrated on the group of patients with relatively mild symptoms. He studied the incidence and course of post-irradiation diarrhea in 196 patients treated for carcinoma of the uterine cervix or endometrium. The aims of the present study were: 1) to determine the incidence, course and prognostic significance of post-irradiation diarrhea; 2) to assess the influence of radiotherapy factors; 3) to study the relation of bile acid metabolism to post-irradiation diarrhea; 4) to investigate whether local factors (reservoir function) were primarily responsible. (Auth.)

  18. Post-duralpunktur hovedpine

    DEFF Research Database (Denmark)

    Dahl, J B; Rosenberg, J

    1990-01-01

    Post dural puncture headache is one of the major complications of spinal anaesthesia. In order to establish this diagnosis, the headache must be dependent on the position of the patient. The symptoms are probably due to leakage of cerebro-spinal fluid from the subarachnoid space to the epidural...

  19. Post-death cloning of endangered Jeju black cattle (Korean native cattle): fertility and serum chemistry in a cloned bull and cow and their offspring.

    Science.gov (United States)

    Kim, Eun Young; Song, Dong Hwan; Park, Min Jee; Park, Hyo Young; Lee, Seung Eun; Choi, Hyun Yong; Moon, Jeremiah Jiman; Kim, Young Hoon; Mun, Seong Ho; Oh, Chang Eon; Ko, Moon Suck; Lee, Dong Sun; Riu, Key Zung; Park, Se Pill

    2013-12-17

    To preserve Jeju black cattle (JBC; endangered native Korean cattle), a pair of cattle, namely a post-death cloned JBC bull and cow, were produced by somatic cell nuclear transfer (SCNT) in a previous study. In the present study, we examined the in vitro fertilization and reproductive potentials of these post-death cloned animals. Sperm motility, in vitro fertilization and developmental capacity were examined in a post-death cloned bull (Heuk Oll Dolee) and an extinct nuclear donor bull (BK94-13). We assessed reproductive ability in another post-death cloned cow (Heuk Woo Sunee) using cloned sperm for artificial insemination (AI). There were no differences in sperm motility or developmental potential of in vitro fertilized embryos between the post-death cloned bull and its extinct nuclear donor bull; however, the embryo development ratio was slightly higher in the cloned sperm group than in the nuclear donor sperm group. After one attempt at AI, the post-death cloned JBC cow became pregnant, and gestation proceeded normally until day 287. From this post-death cloned sire and dam, a JBC male calf (Heuk Woo Dolee) was delivered naturally (weight, 25 kg). The genetic paternity/maternity of the cloned JBC bull and cow with regard to their offspring was confirmed using International Society for Animal Genetics standard microsatellite markers. Presently, Heuk Woo Dolee is 5 months of age and growing normally. In addition, there were no significant differences in blood chemistry among the post-death cloned JBC bull, the cow, their offspring and cattle bred by AI. This is the first report showing that a pair of cattle, namely, a post-death cloned JBC bull and cow, had normal fertility. Therefore, SCNT can be used effectively to increase the population of endangered JBC. PMID:23955237

  20. Communication from La Poste

    CERN Multimedia

    2005-01-01

    We should like to remind users that post sent to the CERN site must be correctly addressed in order to reach the right destination as quickly as possible: Correspondence (goods subject to Swiss VAT): Surname, first name CERN (Department, Building & Mailbox) Route de Meyrin 385 Case Postale 1211 Genève 23 CERN (Switzerland) Official orders (goods not subject to Swiss VAT): CERN Goods Reception Order number ( Ca, Ct, Cl....) For the attention of: (surname, first name) Route de Meyrin 385 Case Postale 1211 Genève 23 CERN (Switzerland) Please inform your suppliers of the above addresses. Last minute Swiss motorway sticker on sale at the POST OFFICE, Main Building (63 R 02) 40.- CHF

  1. Post-human Viewing

    DEFF Research Database (Denmark)

    Blaagaard, Bolette

    2013-01-01

    This article discusses the relationship between theories of photography and mobile phone footage. In doing so, it asks if theories of photography still apply in a technologically saturated world of imagery. Technology is an increasingly important part of viewing imagery today and enables imagery ...... implications. The author takes photojournalism and, in particular, mobile phone footage as a starting point for an exploration of the (post-human) body as evidence and sign of authenticity in the modern age of digital communications and journalism....... become part of a global cultural flow, thus calling into question the physical connection between viewer and image. This article analyses what happens to that connection when not only the image but also the physical body is mediated and challenged in post-human relations, and examines the ensuing ethical...

  2. 78 FR 2950 - Proposed Posting and Posting of Stockyards

    Science.gov (United States)

    2013-01-15

    ... posted the stockyards. On January 26, 2010, we published a notice in the Federal Register (75 FR 4039... posting AZ-117 Robertson Horse Sales, Benson, April 28, 2010. Arizona. CA-193 Westside Auction...

  3. Transplante de fígado: resultados de aprendizagem de pacientes que aguardam a cirurgia Trasplante de hígado: estrategias de enseñanza utilizadas con pacientes que esperan por la cirugía Liver transplantation: teaching strategies used with patients waiting for surgery

    Directory of Open Access Journals (Sweden)

    Karina Dal Sasso

    2005-08-01

    Full Text Available O objetivo deste estudo é descrever os resultados de aprendizagem da experiência de implementação de estratégias de ensino com os pacientes que serão submetidos a transplante de fígado. Uma delas é a entrega de um manual de orientação aos pacientes que entram no programa, com posterior aplicação de questionário relacionado ao conteúdo do manual. Analisou-se 13 pacientes em lista de espera para transplante de fígado, todos ocupando as primeiras posições no cadastro técnico. Em relação às respostas obtidas dos questionários aplicados, a média de acertos foi de 80,6%, sendo que apenas um paciente acertou todas as questões. Durante a correção e esclarecimento das dúvidas, concluiu-se que a leitura do manual de orientação e a aplicação do questionário proporcionam esclarecimento melhor dos pacientes e de seus familiares em relação aos aspectos mais importantes da cirurgia.Este estudio tiene como objetivo describir la experiencia de implementación de estrategias de enseñanza con pacientes que van a ser sometidos al trasplante de hígado. Una de ellas es la entrega de un manual de orientación a los pacientes que empiezan el programa, con la posterior aplicación de un cuestionario relacionado al contenido del manual. Fueron analizados 13 pacientes que estaban aguardando el trasplante de hígado, ocupando las primeras posiciones en el registro técnico. Con relación a las respuestas obtenidas de los cuestionarios aplicados, el promedio de respuestas correctas fue del 83.8%, siendo que solamente un paciente tuvo todas las respuestas correctas. Durante la revisión de las respuestas y aclaración de las dudas, los autores concluyeron que la lectura del manual de orientación y la aplicación del cuestionario proporcionan una aclaración a los pacientes y sus familiares con respecto a los aspectos más importantes de la cirugíaThis study aims to describe the learning results of the implementation of teaching

  4. Post-Quantum Cryptography

    OpenAIRE

    Gauthier Umana, Valérie; Knudsen, Lars Ramkilde; Leander, Gregor

    2011-01-01

    The security of almost all the public-key cryptosystems used in practice depends on the fact that the prime factorization of a number and the discrete logarithm are hard problems to solve. In 1994, Peter Shor found a polynomial-time algorithm which solves these two problems using quantum computers. The public key cryptosystems that can resist these emerging attacks are called quantum resistant or post-quantum cryptosystems. There are mainly four classes of public-key cryptography that are bel...

  5. Post-keratoplasty glaucoma

    OpenAIRE

    S. A. Malozhen; S. V. Trufanov; S. Yu. Petrov

    2015-01-01

    Post-keratoplasty glaucoma (PKG) remains one of the leading causes of blindness due to the loss of optic nerve fibers and irreversible graft opacification. PKG is a challenge due to diagnostic and therapeutic difficulties and recalcitrant course. This paper reviews main pre-operative PKG risk factors such as pre-existing glaucoma, corneal disorders for which keratoplasty is performed, and lens status. Intraoperative errors that caused by ocular hypertension (tight suturing, larger trephine si...

  6. Post-ATC Reviews

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Guatemala City,a most populous and prosperous metropolitan in Central America,was once again an eye-catcher for hosting for the second time,on April 16-19,the Council of Representatives'meeting of International Textile andClothing Bureau(ITCB)at the time when it has been already two years post the Agreement on Textiles and Clothing (ATC).

  7. Post-partum pancreatitis.

    OpenAIRE

    Pai P; Shah H; Samsi A

    1993-01-01

    Acute pancreatitis in pregnancy and post-partum period, rarely encountered in surgical practice, can have a lethal effect on the mother and the foetus. We report here a case of a 35 year old tertigravida who presented with high grade fever, abdominal pain with distension, tachycardia and tachypnoea. Chest examination and X-rays were suggestive of pneumonia. The abdomen was tense and tender. Peristalsis was absent. Ultrasound revealed presence of fluid in the abdominal cavity which on paracent...

  8. Post-Cruise Questionnaire - Legacy

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Post-Cruise Questionnaire is a mandatory post trip legal document that observers fill out after every trip they have completed.

  9. Post Newtonian Rigid Body

    OpenAIRE

    Xu, Chongming; Tao, Jin-he; Wu, Xuejun

    2003-01-01

    In this paper, it is the first time to construct a complete post-Newtonian (PN) model of a rigid body by means of a new constraint on the mass current density and mass density. In our PN rigid body model most of relations, such as spin vector proportional to the angular velocity, the definition on the moment of inertia tensor, the key relation between the mass quadrupole moment and the moment of inertia tensor, rigid rotating formulae of mass quadrupole moment and the moment of inertia tensor...

  10. Post-Quantum Cryptography

    DEFF Research Database (Denmark)

    Gauthier Umana, Valérie

    . The public key cryptosystems that can resist these emerging attacks are called quantum resistant or post-quantum cryptosystems. There are mainly four classes of public-key cryptography that are believed to resist classical and quantum attacks: code-based cryptography, hash-based cryptography, lattice......-based cryptography and multivariate public-key cryptography. In this thesis, we focus on the rst two classes. In the rst part, we introduce coding theory and give an overview of code-based cryptography. The main contribution is an attack on two promising variants of McEliece's cryptosystem, based on quasi...

  11. [Post Stroke Dementia].

    Science.gov (United States)

    Ihara, Masafumi

    2016-07-01

    Post-stroke dementia (PSD) is a clinical entity that encompasses all types of dementia following an index stroke. Current evidence suggests that 25-30% of ischemic stroke survivors develop immediate or delayed vascular cognitive impairment or vascular dementia. The type of stroke can be either ischemic, hemorrhagic or hypoperfusive. There are multiple risk factors for PSD including older age, family history, genetic variants, low educational status, vascular comorbidities, prior transient ischemic attack or recurrent stroke and depressive illness. Pre-stroke dementia refers to the occurrence of cognitive impairment before the index stroke, which may be caused by a vascular burden as well as insidious neurodegenerative changes. Neuroimaging determinants of dementia after stroke include silent brain infarcts, white matter changes, lacunar infarcts and medial temporal lobe atrophy. Published clinical trials have not been promising and there is little information on whether PSD can be prevented using pharmacological agents. Control of vascular disease risk and prevention of recurrent strokes are key to reducing the burden of cognitive decline and post-stroke dementia. Modern imaging and analysis techniques will help to elucidate the mechanism of PSD and establish better treatment. PMID:27395459

  12. Shared consultant physician posts.

    LENUS (Irish Health Repository)

    Cooke, J

    2012-01-31

    Our aim was to assess the acceptability and cost-efficiency of shared consultancy posts. Two consultant physicians worked alternate fortnights for a period of twelve months. Questionnaires were distributed to general practitioners, nurses, consultants and junior doctors affected by the arrangement. Patients or their next of kin were contacted by telephone. 1\\/17 of consultants described the experience as negative. 14\\/19 junior doctors reported a positive experience. 11 felt that training had been improved while 2 felt that it had been adversely affected. 17\\/17 GPs were satisfied with the arrangement. 1\\/86 nurses surveyed reported a negative experience. 1\\/48 patients were unhappy with the arrangement. An extra 2.2 (p<0.001) patients were seen per clinic. Length of stay was shortened by 2.49 days (p<0.001). A saving of 69,212 was made due to decreased locum requirements. We present data suggesting structured shared consultancy posts can be broadly acceptable and cost efficient in Ireland.

  13. Post Stamp Perforation Recognition

    OpenAIRE

    Koníček, Vladimír

    2008-01-01

    Rozpoznávání zoubkování poštovních známek je důležitým faktorem při posuzování pravosti poštovní známky. Typ a rozměr zoubkování mají výrazný vliv na cenu poštovní známky. Tato práce se zabývá navrhem detektoru zoubkování poštovních známek. Cílem práce je vytvořit aplikaci, která z fotografie určí zoubkování zobrazené poštovní známky. Aplikace pro práci s obrazy využívá knihovnu OpenCV. Post stamp perforation recognition is important factor in authentication of post stamps. Type and perfor...

  14. Independents' group posts loss

    International Nuclear Information System (INIS)

    Low oil gas prices and special charges caused the group of 50 U.S. independent producers Oil and Gas Journal tracks to post a combined loss in first half 1992. The group logged a net loss of $53 million in the first half compared with net earnings of $354 million in first half 1991, when higher oil prices during the Persian Gulf crisis buoyed earnings in spite of crude oil and natural gas production declines. The combined loss in the first half follows a 45% drop in the group's earnings in 1991 and compares with the OGJ group of integrated oil companies whose first half 1992 income fell 47% from the prior year. Special charges, generally related to asset writedowns, accounted for most of the almost $560 million in losses posted by about the third of the group. Nerco Oil and Gas Inc., Vancouver, Wash., alone accounted for almost half that total with charges related to an asset writedown of $238 million in the first quarter. Despite the poor first half performance, the outlook is bright for sharply improved group earnings in the second half, assuming reasonably healthy oil and gas prices and increased production resulting from acquisitions and in response to those prices

  15. Enfermagem em transplante de células tronco hematopoéticas: produção científica de 1997 a 2007 El papel de la enfermería en el trasplante de células tronco hematopoyéticas: producción científica de 1997 a 2007 Nursing and hematopoietic stem cell transplantation: scientific production from 1997 to 2007

    Directory of Open Access Journals (Sweden)

    Nen Nalú Alves das Mercês

    2010-04-01

    Full Text Available OBJETIVO: Identificar as publicações de enfermagem existentes no período de 1997 a 2007 referentes à temática do transplante de medula óssea e suas principais características. MÉTODOS: Estudo bibliométrico das produções científicas indexadas nas bases de dados: BDENF, LILACS, SciElo, CEPEn e Banco de Dissertações e Teses da CAPES, utilizando os descritores: enfermagem e transplante de medula óssea no recorte temporal de 1997 a 2007 RESULTADOS: Foram incluídos 37 trabalhos em âmbito nacional, sendo 17 dissertações, 2 teses e 18 artigos publicados em periódicos brasileiros, que abordam o cuidado de enfermagem, organização e gerenciamento de Serviços de Transplante de Medula Óssea, qualidade de vida, sofrimento psíquico e produção de conhecimento. CONCLUSÕES: A produção científica, mesmo que quantitativamente pequena, está em ascensão. E está baseada em teorias, conceitos e métodos, principalmente de orientação qualitativa.OBJETIVO: Identificar las publicaciones de enfermería existentes en el período de 1997 a 2007 referentes a la temática del trasplante de médula ósea y sus principales características. MÉTODOS: Estudio bibliométrico de las producciones científicas indexadas en las bases de datos: BDENF, LILACS, SciElo, CEPEn y en el banco de disertaciones y tesis de la CAPES, utilizando los descriptores: enfermería y trasplante de medula ósea en el intervalo de 1997 a 2007 RESULTADOS: Fueron incluidos 37 trabajos del ámbito nacional, siendo 17 disertaciones, 2 tesis y 18 artículos, publicados en periódicos brasileños, que abordan el cuidado de enfermería, la organización y administración de los Servicios de Trasplante de Médula Ósea, la calidad de vida, el sufrimiento psíquico, y, la producción de conocimiento. CONCLUSIONES: La producción científica, cuantitativamente pequeña, está aumentando; ella está basada en teorías, conceptos y métodos, principalmente de orientaci

  16. Post retention and post/core shear bond strength of four post systems.

    Science.gov (United States)

    Stockton, L W; Williams, P T; Clarke, C T

    2000-01-01

    As clinicians we continue to search for a post system which will give us maximum retention while maximizing resistance to root fracture. The introduction of several new post systems, with claims of high retentive and resistance to root fracture values, require that independent studies be performed to evaluate these claims. This study tested the tensile and shear dislodgment forces of four post designs that were luted into roots 10 mm apical of the CEJ. The Para Post Plus (P1) is a parallel-sided, passive design; the Para Post XT (P2) is a combination active/passive design; the Flexi-Post (F1) and the Flexi-Flange (F2) are active post designs. All systems tested were stainless steel. This study compared the test results of the four post designs for tensile and shear dislodgment. All mounted samples were loaded in tension until failure occurred. The tensile load was applied parallel to the long axis of the root, while the shear load was applied at 450 to the long axis of the root. The Flexi-Post (F1) was significantly different from the other three in the tensile test, however, the Para Post XT (P2) was significantly different to the other three in the shear test and had a better probability for survival in the Kaplan-Meier survival function test. Based on the results of this study, our recommendation is for the Para Post XT (P2). PMID:11203854

  17. Post-traumatic osteomyelitis

    International Nuclear Information System (INIS)

    Only 24 patients with post-traumatic osteomyelitis were found from records covering a period of five years. Twenty-two of them with complete medical histories are reviewed here. The radiographs were usually taken through plaster of Paris, and therefore the radiological diagnosis was established later than the clinical one in half of the cases. There were only four cases with a true delay. The primary radiological signs leading to the osteomyelitis diagnosis appeared on average 4.3 months after the assumed time of infection. It is our feeling that the current widespread use of antibiotics causes the diagnosis to be delayed even more than it was in the days of haematogenous osteomyelitis. Continuous formation of periosteal new bone layers indicated poorer prospects for healing of the osteomyelitis. (orig.)

  18. Post dengue neurological complication.

    Science.gov (United States)

    Hasliza, A H; Tohid, H; Loh, K Y; Santhi, P

    2015-01-01

    Dengue infection is highly endemic in many tropical countries including Malaysia. However, neurological complications arising from dengue infection is not common; Gullain-Barre syndrome (GBS) is one of these infrequent complications. In this paper, we have reported a case in which a 39-year-old woman presented with a neurological complication of dengue infection without typical symptoms and signs of dengue fever. She had a history of acute gastroenteritis (AGE) followed by an upper respiratory tract infection (URTI) weeks prior to her presentation rendering GBS secondary to the post viral URTI and AGE as the most likely diagnosis. Presence of thrombocytopenia was the only clue for dengue in this case. PMID:27099661

  19. Post-traumatic syringomyelia

    Directory of Open Access Journals (Sweden)

    Agrawal Amit

    2007-01-01

    Full Text Available Progressive post-traumatic cystic syringomyelia is an uncommon and increasingly recognized cause of morbidity following spinal cord injury. We hereby report a 35-year-old gentleman who sustained wedge compression fracture of L-1 vertebral body 15 years back and had complete paraplegia with bowel/bladder involvement. The neurological deficit recovered with minimal residual motor deficits and erectile dysfunction. He presented now with increasing neurological deficits associated with pain and paresthesia. The MRI spine showed a syrinx extending from the site of injury up to the medulla. He underwent a syringo-peritoneal shunt and at follow-up his pain and motor functions had improved but erectile dysfunction was persisting.

  20. Post Newtonian Rigid Body

    CERN Document Server

    Xu, C; Wu, X; Wu, Xuejun

    2004-01-01

    In this paper, it is the first time to construct a complete post-Newtonian (PN) model of a rigid body by means of a new constraint on the mass current density and mass density. In our PN rigid body model most of relations, such as spin vector proportional to the angular velocity, the definition on the moment of inertia tensor, the key relation between the mass quadrupole moment and the moment of inertia tensor, rigid rotating formulae of mass quadrupole moment and the moment of inertia tensor, are just the extension of the main relations in Newtonian rigid body model. When all of $1/c^2$ terms are neglected, the PN rigid body model and the corresponding formulae reduce to Newtonian version. The key relation is obtained in this paper for the first time, which might be very useful in the future application to problems in geodynamics and astronomy.

  1. Post-Olympism?

    DEFF Research Database (Denmark)

    Christensen, Mette Krogh

    The Olympic ideal and the Olympic Games stand as symbols of global cooperation, international understanding and the bonding fo individuals through the medium of sports. However, throughout the twentieth century, Olympic rhetoric waas often confronted by a different reality. The Games have regularly...... been faced by crises that have threatened the spirit of Olympism and even the Games themselves. Given the many changes that have occurred in the Olympic Games during the past century it seems reasonable to ask if this global event has a future and, if so, what form it might take. Whit this larger issue...... in mind, the authors of Post-Olympism? ask probing questions about the following: 1) The infamous 1936 Olympics, 2) the effect of new techonologies on the Games, 3) the future impact of the 2008 Beijing Games on China and of China on the Olympics, 4) the local and regional impact of the Sydney 'green...

  2. 电喷雾串联质谱法定性分析新型毒品亚甲基双氧甲基卡西酮%Qualitative Analysis of New-type Drug bk-MDMA by ESI-MS/MS

    Institute of Scientific and Technical Information of China (English)

    周志刚; 严忠雍; 张小军; 杨宝峰

    2015-01-01

    建立一种准确定性奶茶等样品中亚甲基双氧甲基卡西酮(bk-MDMA)的电喷雾串联质谱检测方法.样品通过甲醇提取,提取液高速离心后用滤膜过滤,上机液用蠕动泵进样进行电喷雾串联质谱定性分析.通过母离子扫描和子离子扫描研究了bk-MDMA的质谱裂解途径,通过分析比较选择合适的定性离子.通过对锥孔电压、碰撞电压等质谱条件的优化和基质干扰分析,建立了合适的串联质谱检测条件.电喷雾串联质谱方法与GC-MS方法相比更加快速简便,通过串联质谱的二级质谱定性准确度更高.利用本方法对5个物证实际样品进行了分析,结果显示均含有bk-MDMA.本方法快速、准确、灵敏度高,可广泛用于司法物证鉴定等领域bk-MDMA的定性分析.

  3. Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors

    Directory of Open Access Journals (Sweden)

    Zajac Paul

    2006-11-01

    Full Text Available Abstract Human polyomavirus BK (BKV has been implicated in oncogenic transformation. Its ability to replicate is determined by the binding of its large tumor antigen (LTag to products of tumor-suppressor genes regulating cell cycle, as specifically p53. We investigated CD8+ T immune responses to BKV LTag portions involved in p53 binding in HLA-A*0201+ BKV LTag experienced individuals. Peptides selected from either p53-binding region (LTag351–450 and LTag533–626 by current algorithms and capacity to bind HLA-A*0201 molecule were used to stimulate CD8+ T responses, as assessed by IFN-γ gene expression ex vivo and detected by cytotoxicity assays following in vitro culture. We observed epitope-specific immune responses in all HLA-A*0201+ BKV LTag experienced individuals tested. At least one epitope, LTag579–587; LLLIWFRPV, was naturally processed in non professional antigen presenting cells and induced cytotoxic responses with CTL precursor frequencies in the order of 1/20'000. Antigen specific CD8+ T cells were only detectable in the CD45RA+ subset, in both CCR7+ and CCR7- subpopulations. These data indicate that widespread cellular immune responses against epitopes within BKV LTag-p53 binding regions exist and question their roles in immunosurveillance against tumors possibly associated with BKV infection.

  4. Retention of Root Canal Posts

    DEFF Research Database (Denmark)

    Sahafi, A; Benetti, Ana Raquel; Flury, S;

    2015-01-01

    The aim of this study was to investigate the effect of the cement film thickness of a zinc phosphate or a resin cement on retention of untreated and pretreated root canal posts. Prefabricated zirconia posts (CosmoPost: 1.4 mm) and two types of luting cements (a zinc phosphate cement [DeTrey Zinc......] and a self-etch adhesive resin cement [Panavia F2.0]) were used. After removal of the crowns of 360 extracted premolars, canines, or incisors, the root canals were prepared with a parallel-sided drill system to three different final diameters. Half the posts did not receive any pretreatment. The other...... half received tribochemical silicate coating according to the manufacturer's instructions. Posts were then luted in the prepared root canals (n=30 per group). Following water storage at 37°C for seven days, retention of the posts was determined by the pull-out method. Irrespective of the luting cement...

  5. Post combustion in converter steelmaking

    Energy Technology Data Exchange (ETDEWEB)

    Oghbasilasie, H.; Holappa, L.

    1997-12-31

    The purpose of this work is to study the fundamentals of post combustion and the effect of different process parameters on the post combustion ratio (PCR) and heat transfer efficiency (HTE) in converter steelmaking process. The PCR and HTE have been determined under normal operating conditions. Trials assessed the effect of lance height, vessel volume, foaming slag and pellet additions on PCR and HTE. Based on enthalpy considerations, post combustion of CO gas is regarded as one of the most effective means of increasing the heat supply to the BOP. The thermodynamic study of gas-metal-slag reactions gives the limiting conditions for post combustion inside the converter reactor. Different process parameters influencing both thermodynamic equilibria and kinetic conditions can greatly affect the post combustion ratio. Different features of converter processes as well smelting reduction processes utilizing post combustion have been reviewed. (orig.) SULA 2 Research Programme; 26 refs.

  6. Japan Post: Retreat or Advance?

    OpenAIRE

    Gary Clyde Hufbauer; Julia Muir

    2012-01-01

    Legislation to reform Japan Post is again gathering steam in Tokyo. A new postal bill is taking shape, in the form of amendments to the existing Postal Privatization Law dating from the Koizumi era—all put forward under the larger banner of post-earthquake reconstruction finance and the government's efforts to minimize consumption tax hikes. The latest version of "postal reform" legislation envisages "privatization" of Japan Post through the sale of up to two-thirds of government shares, but ...

  7. Post-16 update

    Science.gov (United States)

    1999-07-01

    (post16) Faces of Physics To study a physics course post-16 is take out an option on your future. But physics itself is very varied, and so is what you might do with it. It seems right that post-16 physics courses reflect important aspects of this variety. Physics varies with why people do it. As reliable knowledge, physics is often essential to making things happen. This is physics as feeding into technology, and quite often feeding off technology. The human urge here is the urge to create things that work. It drives individual inventors; it drives large teams in multinational companies. At the opposite end of this spectrum is physics driven by curiosity, by the urge to find out. The stock examples are the grand discoveries from the expansion of the universe to the discovery of the nucleus of atoms. But the physicist's curiosity is often on a more detailed, even finicky scale: how exactly do the molecules of this polymer respond to stress?; just how do ions implanted in this material modify its conductivity? It is clear to me that a decent post-16 physics course must respect and reflect both. This is by no means a matter of `basic laws and their applications'. It is a matter of recognizing two fundamental interests, in doing and in explaining, and of recognizing that they are at once closely interdependent and worlds apart. Ideas in physics are also not of one kind. One opposition is the idea of describing Nature in terms of deterministic physical laws, as against describing Nature as the predictable outcome of probabilistic behaviour `underneath'. The first has gripped the Western imagination since at least the time of Descartes. The second has increasingly come to the fore, especially in thermodynamics with the idea that we can only make processes work by fixing the circumstances so that uncaring atoms and molecules happen by chance to do what we want. Now in quantum theory both ideas - determinism and randomness - co-exist. Post-16 physics courses are not in

  8. Battery Post-Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Post-test diagnostics of aged batteries can provide additional information regarding the cause of performance degradation, which, previously, could be only inferred...

  9. Post-traumatic stress disorder

    Science.gov (United States)

    ... Post-traumatic stress disorder References American Psychiatric Association. Diagnostic and statistical manual of mental disorders . 5th ed. Arlington, VA: American Psychiatric Publishing. 2013. ...

  10. Doença coronária obstrutiva em hepatopatas crônicos que aguardam transplante hepático Enfermedad coronaria obstructiva en hepatópatas crónicos que aguardan trasplante hepático Obstructive coronary disease in patients with chronic liver disease awaiting liver transplantation

    Directory of Open Access Journals (Sweden)

    Moacir Fernandes de Godoy

    2011-01-01

    grado importante con consecuente aumento de riesgo o incluso contraindicación para trasplante hepático. OBJETIVOS: Analizar la contribución de los factores de riesgo clásicos para la enfermedad arterial coronaria (EAC en pacientes portadores de IHA con y sin coronariopatía obstructiva. MÉTODOS: Evaluación de los factores de riesgo para EAC en 119 pacientes, en un servicio de referencia para trasplante hepático, con las siguientes características: más de 40 años de edad, portadores de IHA y sometidos a cinecoronariografía. RESULTADOS: Coronariopatía obstructiva fue detectada en 21 (17,6% de los casos. Estos pacientes presentaban realmente niveles bajos de colesterol, siendo de 129,0±53,5mg/dL con mediana de 117,0mg/dL en los hepatópatas con coronarias normales y 135,4±51,7mg/dL con mediana de 122,0mg/dL en los hepatópatas con coronariopatía obstructiva (P=0,8215. En la regresión logística multivariada, la edad, el sexo, el índice de masa corporal, así como las presencias de diabetes, de tabaquismo y de etilismo no tuvieron significancia estadística aislada en la diferenciación entre los grupos. También no hubo asociación con la etiología de la IHA. A su vez, la hipertensión arterial se mostró relevante en la asociación con EAC (P=0,0474. CONCLUSIÓN: Sólo la hipertensión arterial fue factor de riesgo con significancia estadística para el desarrollo de EAC en pacientes con IHA aguardando trasplante hepático. Por ser un factor de riesgo cambiable, este hallazgo orienta hacia una práctica de actitudes terapéuticas en la tentativa de evitarse o retardar el desarrollo de la EAC en estos pacientes.BACKGROUND: Advanced liver failure (ALF usually presents hypocholesterolemia. Nevertheless, some patients with ALF develops major coronary obstructive diseases with consequent increased risk or contraindication to liver transplantation. OBJECTIVE: To analyze the contribution of classical risk factors for coronary artery disease (CAD in patients

  11. NEWS: Post-16 update

    Science.gov (United States)

    Campbell, Peter

    2000-07-01

    post16.gif As a teacher of physics it is very easy to become preoccupied with particulars of courses, or topics or even single concepts. Concerned with imminent student audiences and desired learning outcomes, the daily challenge is to summon satisfactory teaching approaches and resources for the job at hand. For the conscientious teacher, assessment outcomes may too often seem a judgment on our own efforts rather than those of our students. From time to time we may step back and think bigger, for example while planning a recruitment event, or while away from work on holiday. We may be successful locally. But why, at a time when books and television documentaries popularizing science have a large following, has physics education been facing declining numbers? Many recognize that physics has an essential contribution to make to the training of science or engineering specialists, but we know that it is also important for the skilled worker, the informed citizen and, in fact, for anyone trying to make sense of the world. So what are the best ways forward for post-16 physics? To make any impact on the bigger picture requires organization, thinking and meeting time among people in diverse roles: teachers and curriculum managers; university lecturers; employers and professional bodies; unitary awarding bodies; regulatory and funding agencies; and even Government. For the past few years, the Institute of Physics post-16 Initiative has created an unrivalled opportunity to address the wider issues. Its Shaping the Future booklets series was designed to stimulate informed discussion and debate, by providing background information and analysis. Taken together, the booklets should help all those concerned with physics education to understand where we are now, and why. Literally dozens of people have contributed to a review and analysis of physics education. Each booklet is a 48-page smorgasbord in A4 landscape format, containing many examples of good practice, basic but

  12. Post-16 update

    Science.gov (United States)

    1999-11-01

    (Post-16 Initiative) Engineering Physics? Many A-level physics students do not go on to study physics. For them physics is a support subject, either just for fun or just for the grade. Where physics is a lead subject some students go on to study physics but many more go on to study engineering. So can we deliberately give some aspects of an A-level course an engineering flavour? Electromagnetism would seem a good place to start. There is a clear `physics' route into this topic, a microscopic forces and fields view of the situation. But do our students really need to look at it this way? All electromagnetic machines are linked magnetic and electric circuits. The design idea is to link these circuits as closely as possible. The electric circuits must be as good as possible, with a high conductivity. The magnetic circuits must be as good as possible, with high permeance. Conductivity depends on area/length. So does permeance. The goodness of an electromagnetic machine (how good it is at its job, which is linking electric and magnetic circuits) scales as the square of its linear dimensions. That means small electromagnetic machines are harder to make, and so the very smallest nanomotors are electrostatic. None of this is new, but many teachers are uncomfortable with it. We are thinking like physicists. Many of our students are not. They deserve us to take the trouble every now and again to encourage them to think a bit differently about a topic, to look at practical ways of discussing design and to give their course an engineering flavour. Philip Britton Coursework in A-level Physics The criteria for the new AS and A-levels have provided the teams developing the specifications with an opportunity to think creatively about how internal assessment is used within post-16 physics courses. Teachers may be concerned that allowing 30% of the marks to be internally assessed will create a burden for them. However, it is possible to look at this in a much more positive light

  13. NEWS: Post-16 update

    Science.gov (United States)

    1999-05-01

    (post16) Making physics connect Doesn't Melvyn Bragg do a wonderful job, engaging both scientists and artists in sensitive discussion on Radio 4 about their methods and their purposes? But every week teachers have the chance to show their students that physics is a way of seeing the world that is well-connected with other aspects of knowledge and culture. The stakes are high: students who fail to appreciate this generally choose not to study the subject beyond GCSE. Most students find our preoccupation with technical detail off-putting. Accepting that we have a syllabus to cover, it's still a question of balance. In our teaching we should aim for variety in order to find ways to connect with every student's interests. Also, we can show that we (the nearest embodiment of a physicist some students will experience) are multidimensional and so fully human. Most important, teachers need flexibility to both encourage and respond to student comment and questions. The first booklet in the discussion series Shaping the Future takes up these themes. Rich in ideas for both immediate use and the longer term, it aims to stimulate debate and improve teaching. Copies cost £5.50 including postage and are available from Ingrid Ebeyer, Post-16 Initiative, Institute of Physics, 76 Portland Place, London W1N 3DH. How far is it? This question is asked in many family cars and school minibuses at the start of a journey, and answered by most in terms of hours and minutes rather than miles. What a good idea for introducing a social and historical perspective to a lesson on distance, velocity and time. How far can you actually get in a day? What is the range of human activity? Walking for eight hours will get many people about 25 miles. A pack horse will progress at much the same rate, but fast riding or a coach and team of horses will get further. Motorway driving (when the cones are on holiday) would take you nearly 500 miles. The 05.15 am train from Penzance arrives in Inverness at 7

  14. Post-16 update

    Science.gov (United States)

    1999-03-01

    Post-16 Initiative logo Physics in Mathematical Mood Later this year, as part of the post-16 initiative of the Institute of Physics, a booklet with the above title will be published. In draft form, the booklet was discussed at the ASE conference in January. Some of the issues raised are briefly set out here. If you have any views to contribute, please write to Simon Carson at the Institute of Physics or e-mail simon.carson@physics.org. A mathematical view of the world is intrinsically a part of physics and therefore physics should be studied in an appropriately mathematical way. However, we all know that, to some students at least, mathematics proves to be a stumbling block rather than a powerful aid to understanding. So how can we help? Realizing that as physics teachers we need to deliver the mathematics necessary to an understanding of our subject is a start. Its corollary is that we need to find the space within the physics core. We may wish to use supplementary courses such as AS mathematics or QCA's new free-standing mathematics units, but requiring additional courses as a prerequisite to a study of A-level physics may deter students. Teaching the mathematics in context may aid understanding but we also must ensure that techniques are seen in a variety of contexts and that at some point the tool is abstracted from the background. As teachers we need to be aware of the very basic mathematical difficulties that students bring with them: the use of calculators, standard form, simple algebraic manipulation, for example. Mathematical arguments need to be developed fully and carefully. Encouraging cooperation and discussion between students may help the less able to understand and the more able to appreciate and develop their own understanding through making explicit their reasoning by explaining it to others. And what of new technology? Software tools allow students to develop their understanding about graphs, for example, enabling them to investigate the

  15. Post-herpetic neuralgia

    Directory of Open Access Journals (Sweden)

    Tontodonati M

    2012-10-01

    Full Text Available Monica Tontodonati,1,* Tamara Ursini,1,* Ennio Polilli,2 Francesco Vadini,3 Francesco Di Masi,4 Damiano Volpone,5 Giustino Parruti41Infectious Disease Clinic, Chieti, 2Microbiology and Virology Unit, Pescara General Hospital, Pescara, 3Psycho-Infectivology Unit, Pescara General Hospital, Pescara, 4Infectious Disease Unit, Pescara General Hospital, Pescara, Italy; 5Local Health District, Pescara, Italy*These authors contributed equally to this workBackground: In spite of the large body of evidence available in the literature, definition and treatment of Post-Herpetic Neuralgia (PHN are still lacking a consistent and universally recognized standardization. Furthermore, many issues concerning diagnosis, prediction and prevention of PHN need to be clarified in view of recent contributions.Objectives: To assess whether PHN may be better defined, predicted, treated and prevented in light of recent data, and whether available alternative or adjunctive therapies may improve pain relief in treatment recalcitrant PHN.Methods: Systematic reviews, meta-analyses, randomized controlled trials, cohort studies and protocols were searched; the search sources included PubMed, Cochrane Library, NICE, and DARE. More than 130 papers were selected and evaluated.Results: Diagnosis of PHN is essentially clinical, but it can be improved by resorting to the many tools available, including some practical and accessible questionnaires. Prediction of PHN can be now much more accurate, taking into consideration a few well validated clinical and anamnestic variables. Treatment of PHN is presently based on a well characterized array of drugs and drug associations, including, among others, tricyclic antidepressants, gabapentinoids, opioids and many topical formulations. It is still unsatisfactory, however, in a substantial proportion of patients, especially those with many comorbidities and intense pain at herpes zoster (HZ presentation, so that this frequent complication of HZ

  16. 75 FR 4039 - Proposed Posting, Posting, and Deposting of Stockyards

    Science.gov (United States)

    2010-01-26

    ... the Federal Register (74 FR 17945-17947) of our proposal to post these 20 stockyards. Since we... location CA-193 Westside Auction Yard, Newman, California. AZ-117 Robertson Horse Sales, Benson,...

  17. POST-RELIGION: TRADITIONALISTS’ ANALYSIS

    Directory of Open Access Journals (Sweden)

    Kirill M. Tovbin

    2013-12-01

    Full Text Available Aim of the study is to describe the phenomenon of post-religion as a specific spiritual sphere of the Post-modernity. Methodology. In the introduction analyzed a variety of methodological approaches, opening his inadequacy applied to the spiritual sphere of Post-modernity: «classic» religious studies, religious studies of traditional spiritual movements and the post-modern religious studies, partly produced Traditionalist school, could - according to the author's hypothesis - become a methodological basis for the most complete analysis of post-religion. Scientific novelty. In the main part of the article crystallized the authorized concept of post-religion, its relation with traditional and religious spiritual realms. Post-religion is positioned as the top of secularism enshrined in the departure from the straight and aggressive secularism of the Modernity, but without recourse to Tradition. Post-religion a simulation spirituality, skillfully imitating the outer areas of traditional spirituality and creates a planar religiosity, radically preventing attached to the vertical line of Traditions. In this regard, are the main artificially selected parameters of post-religion: deconstruction, splitting, virtualization, and collage. Deconstruction is a transformation of spirituality in semiotic set for egocentric selectivity of modern believer. Post-religion’s splitting is deprivation of spirituality center, destruction of sacral Center and the transformation of spirituality in the plane on which the intellectual and sensual wandering post-believer from one semiotic island to another. Virtualization is a displacement field of spiritual tension in a completely virtual area, isolated from the natural conditions of existence and created as his replacement, network discussion sites and galleries. Collage is an arbitrary combination of different semiotic pieces of Tradition with the aim of creating a believable picture of tradition; it is collage leads

  18. The post-secular city

    DEFF Research Database (Denmark)

    Greve, Anni

    Spaces of post-secular engagement Session for the Association of American Geographers (AAG) Annual Meeting, Washington, D.C., United States, 14-18 April 2010 The post-secular city: An emergent international culture? Anni Greve, Abstract The post-secular city is an emergent intellectual field which...... point of departure in cultural trauma theory (Alexander 2003) the paper calls attention to the ability of a site to offer a framework (in terms of meta narrative and ritual choreography) within which each story gains new meaning (Greve 2006). Against the idea that ‘political and ideological differences...

  19. Post-Traumatic Stress Disorder

    Science.gov (United States)

    ... PTSD include violent personal assaults, natural or human-caused disasters, accidents, or military combat. For Consumers General Information Post-Traumatic Stress Disorder ( NIMH ) Anxiety Information Stress Information Depression Information St. John's Wort Information See more Research ...

  20. Calorie Posting in Chain Restaurants

    OpenAIRE

    Bryan Bollinger; Phillip Leslie; Alan Sorensen

    2011-01-01

    We study the impact of mandatory calorie posting on consumers' purchase decisions using detailed data from Starbucks. We find that average calories per transaction fall by 6 percent. The effect is almost entirely related to changes in consumers' food choices—there is almost no change in purchases of beverage calories. There is no impact on Starbucks profit on average, and for the subset of stores located close to their competitor Dunkin Donuts, the effect of calorie posting is actually to inc...

  1. Post-inflationary brane cosmology

    OpenAIRE

    Mazumdar, Anupam

    2000-01-01

    The brane cosmology has invoked new challenges to the usual Big Bang cosmology. In this paper we present a brief account on thermal history of the post-inflationary brane cosmology. We have realized that it is not obvious that the post-inflationary brane cosmology would always deviate from the standard Big Bang cosmology. However, if it deviates some stringent conditions on the brane tension are to be satisfied. In this regard we study various implications on gravitino production and its abun...

  2. Reviewing post-closure issues

    International Nuclear Information System (INIS)

    The study of man-repository-interaction in the post-closure phase is a new field of research. Its evaluation must be based on a proper assessment of the predictive possibilities and limitations of the man-repository-system. Institutional controls would be a way of solving post-closure issues connected with retrievability, human intrusion and safeguards. Their predicted effectiveness is, however, limited to a few hundred years for active and to a few thousand years for passive controls. Therefore the much longer time periods of concern for geological repositories have to be taken into account. Answers to post-closure issues should be based on a rational evaluation of the good and bad aspects of alternative strategies and actions. Such an evaluation reveals tentative answers to post-closure issues. Retrievability: Repository construction and sealing in a way that renders institutional control unnecessary, but not impossible. Human intrusion: Emplacement of unavoidable hazardous waste in deep geological repositories is the best we can do today; alternatives like indefinite storage present higher risks and burdens on future generations. Safeguards: Safeguarding of nuclear material, if considered necessary by future generations, is possible with present day technology. Geological repositories will not enter into a post-closure status before the middle of the next century. Therefore post-closure issues present no urgent problem. (author). 27 refs, 2 tabs

  3. Post-16 update

    Science.gov (United States)

    1999-09-01

    Institute of Physics post-16 initiative, shaping the future Physics education based in IT - sorry ICT! Which, of course, makes for a nifty headline, but as is so often the case with neat slogans, little else. Two formative questions: What, in another decade, will the government of the day call `What you lot should be doing with computers'? and What, of the many things that currently exercise our intellects, will there be anything special to say about in a decade, concerning the use of computers in the teaching of physics? Advancing Physics represents some attempts to come to grips with the second of the two questions above. The first is left to a higher wisdom. In thinking about learning, what can we do with the huge processing power, increasingly available in smaller and less obtrusive packages? What will we do that helps people learn physics, both tomorrow and in 2009? Here are a few suggestions based on development work so far. Wide, reliable and shared access to well ordered learning resources. We have created a CD-ROM, with versions for both student and teacher, that provides a wide range of resources. These do not teach, but do provide. A commitment to allowing a course to evolve and adapt. Electronic publication puts the costs into origination, and not into publication and distribution. A website allows for the community of users to contribute. E-mail networks support individuals and propagate good practice. You can create and explore your own microworlds. The interactive nature of models, and the crafted relationships between the models and the natural world give an insight into the creative imaginary worlds of the physicist. The unreasonable, but pleasurable, success of mathematics in describing the natural world can come to the fore. Measurements that were not possible before are now possible. What was previously indirect, and inaccessible, now becomes a direct measurement, making relationships transparent in new and fruitful ways. The dichotomy between

  4. Medicamentos utilizados em transplante de medula óssea: um estudo sobre combinações dos antimicrobianos potencialmente interativos Medicamentos utilizados en casos de trasplante de médula ósea: un estudio sobre combinaciones antimicrobianas potencialmente interactivas Drugs used in bone marrow transplantation: a study about combinations of antimicrobial potentially interactives

    Directory of Open Access Journals (Sweden)

    Rosimeire Barbosa Fonseca

    2008-12-01

    Full Text Available O objetivo do estudo foi caracterizar o perfil dos medicamentos e identificar combinações decorrentes da co-administração de antimicrobianos potencialmente interativos e outros agentes. 70 prescrições médicas de pacientes submetidos a transplante de medula óssea (TMO, todos internados no Instituto do Coração, São Paulo, Brasil, foram analisadas. Os medicamentos foram classificados de acordo com o sistema Alfa, e o potencial de interação e as características farmacológicas foram listados a partir da literatura. Na analise dos dados utilizou-se estatística descritiva. Verificou-se que 72,7% dos medicamentos apresentaram potencial interativo, destacando-se os precipitadores (79,2% e o fluconazol (85,7% como o antimicrobiano mais envolvido nas combinações, associado ao omeprazol em 40% da amostra. Nos pacientes de TMO, a co-administração de medicamentos potencialmente interativos foi freqüente, condição que, associada à polifarmácia e ao aprazamento simultâneo de horários na administração desses agentes, poderia predispor o paciente a eventos indesejados, afetando, deste modo, a segurança da terapia.El objetivo del estudio fue determinar el perfil de medicamentos e identificar combinaciones por administración conjunta de antimicrobianos potencialmente interactivos y otros agentes. Fueron analizadas 70 prescripciones médicas de pacientes sometidos a trasplante de médula ósea (TMO, todos internados en el Instituto del Corazón, São Paulo, Brasil. Los medicamentos fueron clasificados según el sistema Alfa. El potencial de interacción y las características farmacológicas fueron establecidas según la bibliografía. El análisis de datos a través de estadística descriptiva. El 72,7% de los medicamentos mostró potencial interactivo, destacándose los precipitadores (79,2% y como antimicrobiano más utilizado en las combinaciones el fluconazol (85,7%, siendo asociado al omeprazol en 40% de la muestra. La combinaci

  5. Drug interactions of anti-microbial agents used in hematopoietic stem cell transplantation Interacciones medicamentosas de antimicrobianos utilizados en trasplante de células madre hematopoyéticas Interações medicamentosas de antimicrobianos utilizados em transplante de células-tronco hematopoéticas

    Directory of Open Access Journals (Sweden)

    Rosimeire Barbosa Fonseca Guastaldi

    2011-08-01

    Full Text Available This study analyzed potential drug interactions (PDIs of antimicrobials used in patients of hematopoietic stem cell transplantation and identified associated factors. The sample consisted of 70 patients admitted to a hospital in São Paulo. The PDIs were analyzed through the consultation of the Drug Interactions Facts and Drug Interactions Handbook. Descriptive statistics and logistic regression were used. Half of the sample was exposed to 13 PDIs, which occurred with fluconazole (53.8%, ciprofloxacin (30.8% and sulfamethoxazole-trimethoprim (15.4%. Most (92.3% were of moderate severity, with good evidence (61.6%, early delayed effect (61.5% and need to have their therapy monitored (76.9%. Patients with four or more medications (pEl estudio analizó interacciones medicamentosas potenciales (IMP de antimicrobianos usados en pacientes sometidos a trasplante de células madre hematopoyéticas e identificó los factores asociados las IMP. La casuística fue compuesta por 70 pacientes internados en un Hospital de Sao Paulo. Las IMP fueron a través de la consulta al Drug Interactions Facts y Drug Interactions Handbook. En el análisis de los datos se utilizó estadística descriptiva y regresión logística. Mitad de la muestra fue expuesta a 13 IMP, que ocurrieron con fluconazol (53,8%, ciprofloxacina (30,8% y sulfametoxazol+trimetoprima (15,4%. La mayoría (92,3% presentó gravedad moderada, inicio de efecto demorado (61,5% y necesidad de monitorizar la terapia (76,9%. Cuatro o más medicamentos (pNeste estudo, analisaram-se as interações medicamentosas potenciais (IMP de antimicrobianos, usados em pacientes submetidos a transplante de células-tronco hematopoiéticas e foram identificdos os fatores associados às IMPs. A casuística foi composta por 70 pacientes internados em hospital do município de São Paulo. As IMPs foram analisadas através da consulta ao Drug Interactions Facts e Drug Interactions Handbook. Na análise dos dados, utilizou

  6. Trasplante osteocondral autólogo: una opción para el tratamiento precoz de los defectos del cartílago de rodilla en casos de artrosis ligera Autologous osteochondral transplantation: An option for the early treatment of the knee cartilage defects in the cases of mild arthrosis

    Directory of Open Access Journals (Sweden)

    Araceli Chico Capote

    2004-12-01

    Full Text Available Una lesión de origen traumático en la superficie cartilaginosa de la rodilla puede desencadenar el desarrollo ulterior de artrosis. Se diseñó un estudio preliminar, prospectivo abierto y controlado que incluyó 7 pacientes con afectación radiológica grado I o II de la clasificación de Kellgren y Lawrence que presentaran un defecto condral único en área de apoyo del cóndilo femoral rellenado, mediante visión artroscópica, con cartílago propio tomado de zona de no apoyo con un instrumental construido en el hospital, para determinar la eficacia del trasplante osteocondral autólogo en pacientes con defectos condrales de la articulación de la rodilla. Se evaluaron los resultados clínicos mediante análisis estadístico que incluyó el estadígrafo Chi cuadrado. Se observó que 6 pacientes eran del sexo femenino y 1 del masculino con una edad media de 44,1 años, fueron evaluados al mes del proceder a los 3, 6 y 12 meses y se observó que mejoraron todas las variables clínicas estudiadas de forma estadísticamente significativa, sobre todo la intensidad del dolor y el tiempo en caminar 100 m (p = 0,001 con buena aceptación del proceder en más del 75 % de los enfermos. Se concluyó que el proceder fue eficaz sin presentarse complicaciones después de 1 año de seguimiento.An injury of traumatic origin in the cartilaginous surface of the knee may precipitate the further development of arthrosis. A preliminary, prospective, open and controlled study was designed. It included 7 patients with degree I or II radiological affectation according to Kellgren and Lawrence classification that presented a single chondral defect in the supporting area of the femoral condyle filled up by arthroscopic view with an own cartilage taken from the nonsupporting zone with an instrumental constructed in the hospital to determine the efficiency of the osteochondral autologous transplantation in patients with chondral defects of the knee joint. The clinical

  7. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: Update. Consensus SEMICYUC-SENPE: Liver failure and liver transplantation Recomendaciones para el soporte nutricional y metabólico especializado del paciente crítico: Actualización. Consenso SEMICYUC-SENPE: Insuficiencia hepática y trasplante hepático

    Directory of Open Access Journals (Sweden)

    J. C. Montejo González

    2011-11-01

    tiempo, a la recuperación de los pacientes mediante el control o la reversión de las alteraciones metabólicas apreciadas. En los pacientes críticos que presentan insuficiencia hepática, los conocimientos actuales indican que ésta no parece ser un factor fundamental a la hora de considerar la pauta nutricional. Como en otros pacientes críticos, la vía de aporte de nutrientes debe ser la enteral, siempre que ello sea posible. La composición de la fórmula nutricional debe estar adaptada a la situación de estrés metabólico. A pesar de la base fisiopatológica, clásicamente descrita por algunos autores, que considera al disbalance de aminoácidos un factor desencadenante y mantenedor de la encefalopatía, no hay datos suficientes para recomendar el empleo de soluciones "específicas" (enriquecidas en aminoácidos ramificados y pobres en aminoácidos aromáticos como parte del soporte nutricional en los pacientes con insuficiencia hepática aguda. En los pacientes sometidos a trasplante hepático, el aporte de nutrientes debería iniciarse de manera precoz en el postoperatorio mediante una vía de acceso transpilórica. La prevención de las alteraciones hepáticas asociadas al soporte nutricional debe ser también considerada en diferentes situaciones clínicas.

  8. Thrombotic obstruction of the central venous catheter in patients undergoing hematopoietic stem cell transplantation Obstrucción trombótica del catéter venoso central en pacientes sometidos al trasplante de células-tronco hematopoyéticas Obstrução trombótica do cateter venoso central em pacientes submetidos ao transplante de células-tronco hematopoéticas

    Directory of Open Access Journals (Sweden)

    Kátia Michelli Bertoldi Arone

    2012-08-01

    Full Text Available This is an integrative literature review with the aim of summarizing the prevention measures and treatment of thrombotic obstruction of long-term semi-implanted central venous catheters, in patients undergoing hematopoietic stem cell transplantation. The sample consisted of seven studies, being two randomized controlled clinical trials, three cohort studies and two case series. Regarding the prevention measures, one single study demonstrated effectiveness, which was a cohort study on the oral use of warfarin. In relation to the treatment measures, three studies evidenced effectiveness, one highlighted the efficacy of streptokinase or urokinase, one demonstrated the benefit of using low-molecular-weight heparin and the other treated the obstruction with heparin or urokinase. Catheter patency research shows a restricted evolution that does not follow the evolution of transplantations, mainly regarding nursing care.Se trata de una revisión integradora de la literatura con objeto de sintetizar las medidas de prevención y tratamiento de obstrucción trombótica del catéter venosos central de larga permanencia y semi-implantado, en pacientes sometidos al trasplante de células-tronco hematopoyéticas. La muestra abarcó a siete estudios: dos ensayos clínicos controlados aleatorizados, tres estudios de cohorte y dos series de casos. Respecto a las medidas de prevención, fue identificado un único estudio efectivo, uno cohorte sobre el uso de la warfarina oral. Sobre las medidas de tratamiento, tres estudios evidenciaron efectividad, uno apuntó la eficacia de la estreptoquinasa o uroquinasa, otro mostró beneficio del uso de heparina de bajo peso molecular y otro trató la obstrucción con heparina o uroquinasa. Se observa que la evolución de la investigación sobre la permeabilidad del catéter fue limitada, no acompañando la evolución del trasplante, principalmente respecto a los cuidados de enfermería.Trata-se de revisão integrativa da

  9. Hydrodynamics of post CHF region

    International Nuclear Information System (INIS)

    Among various two-phase flow regimes, the inverted flow in the post-dryout region is relatively less well understood due to its special heat transfer conditions. The review of existing data indicates further research is needed in the areas of basic hydrodynamics related to liquid core disintegration mechanisms, slug and droplet formations, entrainment, and droplet size distributions. In view of this, the inverted flow is studied in detail both analytically and experimentally. Criteria for initial flow regimes in the post-dryout region are given. Preliminary models for subsequent flow regime transition criteria are derived together with correlations for a mean droplet diameter based on the adiabatic simulation data

  10. Post-CTS Delay Insertion

    OpenAIRE

    Jianchao Lu; Baris Taskin

    2010-01-01

    A post-clock-tree-synthesis (post-CTS) optimization method is proposed that suggests delay insertion at the leaves of the clock tree in order to implement a limited version of clock skew scheduling. Delay insertion is limited on each clock tree branch simultaneous with a global monitoring of the total amount of delay insertion. The delay insertion for nonzero clock skew operation is performed only at the clock sinks in order to preserve the structure and the optimizations implemented in the c...

  11. Post tetanic thoracic vertebral change

    International Nuclear Information System (INIS)

    A case report of post tetanic vertebra disclosed multiple thoracic vertebra changes of compressed fracture involving T4, T5, T6 and T7 with partial collapse of T3, T8 and T9. The mechanism of fracture were reviewed. In ordinary compressed fracture produced by acute flexion however post tetanic fracture can be produced by following opisthotonus. Several authors believed to be due to both extensor and flexor muscle groups of violent tetanic convulsion with acute force to the weakest vertebra of T5 or T6 area

  12. Polyomavirus large T antigen is prevalent in urothelial carcinoma post-kidney transplant.

    Science.gov (United States)

    Yan, Ling; Salama, Mohamed E; Lanciault, Christian; Matsumura, Linh; Troxell, Megan L

    2016-02-01

    Viral pathogens have been associated with both infectious disease and neoplasia in transplant recipients. Polyomavirus is emerging as a potential causative agent for genitourinary tract cancer in post-kidney transplant patients. Human papillomavirus (HPV) has a proven role in squamous cancers, but has not been studied in genitourinary malignancies in transplantation. Of 2345 kidney transplants performed at our center over the past 20 years, we identified 16 patients with 20 genitourinary cancers (0.7%), including 13 bladder/ureter carcinomas, 5 renal cell carcinomas (RCCs), and 2 prostate carcinomas. We performed immunohistochemical staining for polyomavirus large T antigen and p16, followed by in situ hybridization for HPV in p16+ cases. Four cases of high-grade invasive urothelial bladder carcinomas were positive for large T. Large T+ urothelial carcinomas developed at least 8 years posttransplant in young men, 3 with history of BK polyoma viremia, 2 of whom had native kidney failure due to reflux/obstruction. In situ hybridization for high-risk HPV was negative in all tested cases. Overall, 3 patients died of carcinoma. All 5 RCCs were negative for both large T and p16; 2 prostate cancers were p16 negative and p16+/HPV negative, respectively. Thus, our study shows a relatively high prevalence of large T antigen in urothelial carcinoma in kidney transplant patients (31%), but not in RCC. Although sample size is small, young patients with obstructive disease may be at particular risk for developing large T-positive urothelial carcinoma. Overall, our data further support the necessities of long-term cancer surveillance for renal transplant patients. PMID:26615524

  13. Gender Mainstreaming and Sustainable Post Disaster Reconstruction,

    OpenAIRE

    Yumarni, Tri; Amaratunga, Dilanthi; Haigh, Richard

    2013-01-01

    Gender inequalities are barriers to achieve sustainable post disaster reconstruction. Mainstreaming gender equality within post disaster reconstruction process can enhance sustainability of reconstruction. Based on a detailed literature review on post disaster reconstruction, this paper identifies pre-requisite conditions for mainstreaming gender within sustainable post disaster reconstruction as ; awareness of gender needs and concerns, a strong gender policy framework, women ...

  14. Credibility improves topical blog post retrieval

    OpenAIRE

    Weerkamp, W.; Rijke, de, M.

    2008-01-01

    Topical blog post retrieval is the task of ranking blog posts with respect to their relevance for a given topic. To improve topical blog post retrieval we incorporate textual credibility indicators in the retrieval process. We consider two groups of indicators: post level (determined using information about individual blog posts only) and blog level (determined using information from the underlying blogs). We describe how to estimate these indicators and how to integrate them into a retrieval...

  15. Subthreshold Post-Traumatic Stress Disorder

    OpenAIRE

    Eylem Ozten; Gokben Hizli Sayar

    2015-01-01

    Post-traumatic stress disorder is a very broad category among mental disorders. Since its inclusion in DSM-III, the diagnostic criteria of post-traumatic stress disorder has undergone a number of changes. The diagnosis and treatment of people who have some symptoms of post-traumatic stress disorder without meeting full criteria still remains controversial. Although subthreshold post-traumatic stress disorder has been debated since it was first defined, the presence of subthreshold post-trauma...

  16. Chaos Theory and Post Modernism

    Science.gov (United States)

    Snell, Joel

    2009-01-01

    Chaos theory is often associated with post modernism. However, one may make the point that both terms are misunderstood. The point of this article is to define both terms and indicate their relationship. Description: Chaos theory is associated with a definition of a theory dealing with variables (butterflies) that are not directly related to a…

  17. Testing post-editing guidelines

    DEFF Research Database (Denmark)

    Flanagan, Marian; Christensen, Tina Paulsen

    2014-01-01

    There is a growing interest in machine translation (MT) and post-editing (PE). MT has been around for decades, but the use of the technology has grown significantly in the language industry in recent years, while PE is still a relatively new task. Consequently, there are currently no standard PE...

  18. Reconsidering Post-Traumatic Stress

    Science.gov (United States)

    Berman, Dene S.; Davis-Berman, Jennifer

    2005-01-01

    This article serves to challenge the prevailing wisdom that suggests that most trauma is followed by post-traumatic stress disorder (PTSD), and is best treated with critical incident stress debriefing (CISD). Instead, recent evidence suggests that many individuals exposed to stress do not experience stress responses. Even those who do, however,…

  19. Post Keynesianism Meets Feminist Economics

    NARCIS (Netherlands)

    I.P. van Staveren (Irene)

    2010-01-01

    textabstractThis article explores the relationships between post-Keynesian economics and feminist economics. It distinguishes three key concepts in each tradition that recommend serious attention in the other tradition: gender, the household and unpaid work and caring as key concepts in feminist eco

  20. Post-closure safety assessment

    International Nuclear Information System (INIS)

    This paper describes the approach under development by UK Nirex Ltd to assess the post-closure safety performance of a deep geological repository for radioactive waste. The term ''post-closure'' refers to the period following operation of the repository, when it has been filled with packaged wastes, backfilled and sealed. Assessment deals with the identification and modelling of the processes and pathways by which radionuclides from the repository may eventually return to the human environment. Post-closure performance assessment forms one element of the comprehensive case that must be developed by UK Nirex Ltd before a repository can be licensed and authorized for construction and operation. The paper outlines the demanding safety requirements for the post-closure period and indicates how they have played a significant part in the development of the Nirex disposal concept. Performance assessment makes extensive use of computer modelling. The models used to assess radionuclide migration from the underground repository to the surface environment are outlined. (author)

  1. Post-partum psychiatric disorders

    Directory of Open Access Journals (Sweden)

    Tanvi Vijay Tuteja

    2016-08-01

    Full Text Available Post-partum period is demanding period characterized by overwhelming biological, social and emotional changes. It requires significant personal and interpersonal adaptation, especially in case of primigravida. Childbearing from the standpoint of psychological medicine is the most complex event in human experience. Traditionally Inwood has classified post-partum psychiatric disorders (PPPD as maternity blues, post-partum (postnatal depression and puerperal psychosis (PP. However the spectrum of postpartum phenomenology is widely characterized by range of emotions from transient mood liability, irritability and weepiness to marked agitation, delusions, confusion and delirium. Untreated post-partum depression can have adverse long term effects. For the mother, the episode can be the precursor of chronic recurrent depression. For her children a mother's ongoing depression can contribute to emotional, cognitive and interpersonal problems in later life. And therefore a thorough knowledge of the same is important for all obstetrician and gynecologists. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2497-2502

  2. Trasplante homólogo vascularizado de trompa y ovario

    OpenAIRE

    Carmona Herrera, Francisco

    1991-01-01

    [spa] a) INTRODUCCIÓN, HIPÓTESIS DE TRABAJO, OBJETIVOS: La esterilidad afecta a un 15% de las parejas que desean tener descendencia. Distintas estadísticas señalan que las alteraciones de la trompa de Falopio son el factor responsable de dicha esterilidad en el 15-50% de casos. El factor tubárico es de difícil solución: en general. Los resultados de la microcirugía no son lo brillantes que en un principio se esperaba. Por otra parte, a pesar de la simplificación actual de las técnicas de FIV,...

  3. Pancreas procurement from multiorgan donors for islet trasplantation.

    Science.gov (United States)

    Ricordi, C; Mazzeferro, V; Casavilla, A; Scotti, C; Pinna, A; Tzakis, A; Starzl, T E

    1992-01-01

    The outcome of human islet isolation procedures can be significantly effected by the technique used for pancreas procurement. In fact, the final step of islet purification using discontinuous density gradients requires a significant difference between the density of the islets and the density of the non-endocrine component of the gland. Therefore, any procedure during multi-organ procurement that will result in edema or degranulation of the acinar tissue will result in failure of the islet purification step. In this report a technique for combined harvesting of liver and pancreas is presented. The use of this procedure can be of assistance to avoid damage to the pancreas that could result in a compromised islet purification for improper handling of the gland even before it arrives to the isolation facility. PMID:21572947

  4. Pancreas procurement from multiorgan donors for islet trasplantation

    OpenAIRE

    Ricordi, C.; Mazzeferro, V.; Casavilla, A.; Scotti, C.; Pinna, A.; Tzakis, A.; Starzl, T.E.

    1992-01-01

    The outcome of human islet isolation procedures can be significantly effected by the technique used for pancreas procurement. In fact, the final step of islet purification using discontinuous density gradients requires a significant difference between the density of the islets and the density of the non-endocrine component of the gland. Therefore, any procedure during multi-organ procurement that will result in edema or degranulation of the acinar tissue will result in failure of the islet pu...

  5. Trasplante hepato-renal. Caso clínico

    OpenAIRE

    Moreno Arroyo, M. Carmen

    2006-01-01

    La hiperoxaliuria primaria tipo I es una enfermedad genética autosómica recesiva, cuyo defecto primario es el déficit, parcial o completo, de la enzima glioxilato aminotransferasa en el hígado que produce la formación de oxalato. El depósito progresivo de oxalato en el riñón es el causante, primero de urolitiasis y nefrocalcinosis, y después de un daño renal progresivo, que lleva a una insuficiencia renal crónica y posteriormente al acúmulo sistémico de oxalato en el sistema músculo-esqueléti...

  6. Post-Digital Literary Studies

    Directory of Open Access Journals (Sweden)

    Florian Cramer

    2016-03-01

    Full Text Available Digital humanities and digital literary studies face much the same challenges as contemporary media art: what will become of them once their media are no longer “new”, and the limitations of processing art as data have become more clearly and widely understood? This paper revisits information aesthetics and computer poetics from the 1960s and 1970s, casting them as precursors of today’s digital humanities, with many of the same issues, achievements and failures, and with their own hype cycles of boom and bust. Conversely, “post-digital” and “Post-Internet” trends in music, graphic design and visual arts may anticipate possible futures of digital humanities and literary studies after the hype has passed.

  7. Post-Acquisition IT Integration

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Yetton, Philip

    2013-01-01

    The extant research on post-acquisition IT integration analyzes how acquirers realize IT-based value in individual acquisitions. However, serial acquirers make 60% of acquisitions. These acquisitions are not isolated events, but are components in growth-by-acquisition programs. To explain how...... serial acquirers realize IT-based value, we develop three propositions on the sequential effects on post-acquisition IT integration in acquisition programs. Their combined explanation is that serial acquirers must have a growth-by-acquisition strategy that includes the capability to improve IT...... integration capabilities, to sustain high alignment across acquisitions and to maintain a scalable IT infrastructure with a flat or decreasing cost structure. We begin the process of validating the three propositions by investigating a longitudinal case study of a growth-by-acquisition program....

  8. Post-transplantation diabetes mellitus

    OpenAIRE

    N Zbiti; K Souly; Z Errami; L Guendouz; L Benamar; F Ezaitouni; N Ouzeddoun; R Bayahia; A Chabraoui; H Rhou

    2012-01-01

    To determine the prevalence of post-kidney transplantation diabetes (PTDM) and to assess its risk factors, we retrospectively studied 92 non-diabetic kidney transplant patients. The immunosuppressive drugs used to prevent rejection included prednisone, a calcineurin inhibitor (cyclosporine or tacrolimus) and an antimetabolite (azathioprine or mycofenolate mofetil). Diabetes was defined according to the WHO criteria and the American Diabetes Association. The mean age of our patients was 35.8 ±...

  9. China's Post Accession WTO Stance

    OpenAIRE

    Glenda Mallon; John Whalley

    2004-01-01

    We discuss China's stance in the WTO post-accession, noting the many issues with implementation of China's accession terms by 2007. We evaluate how much benefit China can realistically receive from WTO membership given current problems with dumping actions against China and trade restrictions against textile and apparel exports. We discuss emerging WTO and non-WTO trade disputes involving China, and China's now extensive regional trade initiatives which raise issues of multilateral regional b...

  10. Country Development Diagnostics Post-2015

    OpenAIRE

    Gable, Susanna; Lofgren, Hans; Osorio-Rodarte, Israel

    2014-01-01

    With the 2015 deadline for the current Millennium Development Goals (MDGs) drawing near, the global community is shaping a new set of international development goals for the longer term. The process has involved consultations led by the UN Open Working Group guided by the 2013 report, a new global partnership of the UN High-level Panel. The work so far indicates that the post-2015 develo...

  11. Post-traumatic Stress Disorder

    OpenAIRE

    M Yadollahie; Javidi, H.

    2011-01-01

    Unexpected extreme sudden traumatic stressor may cause post-traumatic stress disorder (PTSD). Important traumatic events include war, violent personal assault (e.g., sexual assault, and physical attack), being taken hostage or kidnapped, confinement as a prisoner of war, torture, terrorist attack, severe car accidents, and natural disasters. In childhood age sexual abuse or witnessing serious injuries or unexpected death of a beloved one are among important traumatic events.PTSD can be catego...

  12. Sweetpotato post-harvest assessment

    OpenAIRE

    Rees, Debbie; Van Oirschot, Quirien; Kapinga, Regina

    2003-01-01

    For any crop cultivar to be successful it must not only have good production characteristics but also characteristics that ensure the harvested crop is acceptable and suitable for its intended use. Sweetpotato Post-harvest Assessment summarizes work carried out on postharvest aspects of sweetpotato between 1994 and 2002 within collaborative projects involving the Natural Resources Institute (UK), the International Potato Center and the Tanzanian Ministry of Agriculture, with input from the Ke...

  13. Post-traumatic stress disorder

    OpenAIRE

    Jonathan I. Bisson

    2010-01-01

    Post-traumatic stress disorder (PTSD) is characterised by disabling symptoms of re-experiencing a traumatic event, avoidance behaviour, and hyperarousal (e.g., irritability or hypervigilance), lasting at least 1 month. PTSD may affect 10% of women and 5% of men at some stage, and symptoms may persist for several years.Risk factors include major trauma, lack of social support, peritraumatic dissociation, and previous psychiatric or personality factors.

  14. Post-Industrial Cultural Criticism

    DEFF Research Database (Denmark)

    Kammer, Aske

    2015-01-01

    Integrating perspectives from research into cultural and post-industrial journalism, this article presents a pilot study of websites with reviews of arts and culture conducted by amateurs. Such websites constitute a popular space for cultural criticism, and one that challenges traditional...... reviewers have highly specialized knowledge of culture and, on that basis, argues that the emergence of this type of critic might represent a qualitative strengthening of cultural criticism....

  15. Post-dural puncture headache

    Directory of Open Access Journals (Sweden)

    Ghaleb A

    2012-01-01

    Full Text Available Ahmed Ghaleb1, Arjang Khorasani2, Devanand Mangar31Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR, 2Anesthesiology Residency Program, Advocate Illinois Masonic Medical Center, Chicago, IL, 3Florida Gulf to Bay Anesthesiology, Tampa General Hospital, Tampa, FL, USAAbstract: Since August Bier reported the first case in 1898, post-dural puncture headache (PDPH has been a problem for patients following dural puncture. Clinical and laboratory research over the last 30 years has shown that use of smaller-gauge needles, particularly of the pencil-point design, are associated with a lower risk of PDPH than traditional cutting point needle tips (Quincke-point needle. A careful history can rule out other causes of headache. A postural component of headache is the sine qua non of PDPH. In high-risk patients < 50 years, post-partum, in the event a large-gauge needle puncture is initiated, an epidural blood patch should be performed within 24–48 hours of dural puncture. The optimum volume of blood has been shown to be 12–20 mL for adult patients. Complications caused by autologous epidural blood patching (AEBP are rare.Keywords: post-dural puncture headache, gauge, needles, cause, risk, incidence

  16. Escore de cálcio coronariano prediz estenose e eventos na insuficiência renal crônica pré-transplante Score de calcio coronario predice estenosis y eventos en la insuficiencia renal crónica pre trasplante Coronary calcium score as predictor of stenosis and events in pretransplant renal chronic failure

    Directory of Open Access Journals (Sweden)

    Miguel Abraão Rosário

    2010-02-01

    este grupo. La evaluación del score de calcio coronario (SCC por tomografía computarizada ha estado comprobando valor pronóstico en la población sin enfermedad renal. OBJETIVO: Evaluar la exactitud del SCC para detectar EAC obstructiva y prever eventos cardiovasculares en candidatos a trasplante renal comparada a la angiografía coronaria invasiva (ACI cuantitativa. MÉTODOS: Se evaluaron a 97 pacientes con IRC y edad > 35 años. Se consideró como EAC obstructiva la presencia de estenosis > 50% o > 70% por la ACI. Datos descriptivos, concordancia, pruebas diagnósticas, Kaplan-Meier y análisis multivariado se utilizaron. RESULTADOS: El score de Agatston promedio fue de 580,6 ± 1.102,2; los valores mínimos y máximos fueron 0 y 7.994, y mediana de 176. Solamente 14 pacientes tenían score de calcio de cero. No hubo diferencias entre las etnias y la mayor presencia de calcio regional se asoció a la mayor probabilidad de estenosis coronaria en el mismo segmento. El score de calcio de Agatston presentó buena exactitud para el diagnóstico de estenosis, > 50% y > 70% con área bajo la curva ROC de 0,75 y 0,70, respectivamente. En el umbral de 400, el score de calcio identificó el subgrupo con mayor tasa de eventos cardiovasculares en tiempo promedio de seguimiento de 29,1 ± 11,0 meses. CONCLUSIÓN: El SCC en la evaluación de EAC presentó una buena performance diagnóstica y pronostica para eventos cardiovasculares en pacientes con insuficiencia renal crónica (IRC.BACKGROUND: Coronary artery disease (CAD is the major cause of death among chronic renal failure (CRF patients. Traditional, non-invasive exams to detect CAD and to predict events have shown insufficient results in this group. CT Scan evaluation of Coronary Calcium Score (CCS has proven to be of prognostic value for the population reporting no renal condition. OBJECTIVE: To investigate CCS accuracy in detecting obstructive CAD and in predicting cardiovascular events in candidates to renal transplant

  17. Pain Management: Post-Amputation Pain

    Science.gov (United States)

    Pain Management Post-Amputation Pain Volume 8 · Issue 2 · March/April 1998 Text size Larger text Smaller text Java Required Print page Save and share ... by G. Edward Jeffries, MD, FACS Post-Amputation Pain Post-amputation pain is one of the most ...

  18. Post-Traumatic Stress Disorder Basics

    Science.gov (United States)

    ... Don’t Hurt Yourself For More Information Share Post-Traumatic Stress Disorder Basics Download PDF Download ePub Order a free ... might have post-traumatic stress disorder. What is post-traumatic stress disorder, or PTSD? PTSD is a real illness. You ...

  19. Statins for post resuscitation syndrome.

    Science.gov (United States)

    Kämäräinen, Antti; Virkkunen, Ilkka; Silfvast, Tom; Tenhunen, Jyrki

    2009-07-01

    After sudden cardiac arrest, successful resuscitation and return of spontaneous circulation, a multi-faceted ischaemia/reperfusion related disorder develops. This condition now known as post resuscitation syndrome is characterised by marked increases in the inflammatory response and changes in coagulation profile and vascular reactivity. Additionally, the production of reactive oxygen species and activation of cytotoxic cascades of metabolism add to these injury mechanisms resulting in multiorgan perfusion deficits and dysfunction. Especially in the cerebrum these injuries may be the cause of significant morbidity and mortality. Recent evidence has shown that statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) exert numerous beneficial effects in cardiovascular diseases irrespective of the lipid status. Remarkably, these pleiotropic effects seem to extended beyond cardiovascular diseases such as immunomodulative and antioxidative properties. We hypothesised that administration of statins early in the post resuscitation phase would prove beneficial in the resuscitated patient via several pleiotropic effects. These include inhibition of excessive coagulation and inflammatory response, suppression of oxygen radical production and improved vascular reactivity. The discussed effects are mediated via multiple pathways activated in the cardiac arrest victim, to which statins have been shown to have a beneficial modulating effect in experimental settings and non-cardiac arrest patients. To test this hypothesis in clinical practice, a randomized, controlled trial with sufficient power and standardised post resuscitation treatment would be necessary. The generally good tolerance of statin therapy with minimal adverse effects would support this experiment, although a parenteral form of the drug to ensure adequate dosage might be a prerequisite. PMID:19254829

  20. Post Mortem y Tony Manero

    OpenAIRE

    Urrutia, Carolina

    2015-01-01

    Post Mortem, el tercer largometraje de Pablo Larraín, podría ser el preludio de su cinta anterior Tony Manero ; el momento en que el protagonista (en ambas instancias interpretado por Alfredo Castro), cae irreversiblemente en la locura y se vuelve psicópata. La apuesta en ambos filmes es extrema porque asume la representación y la relectura de una época extrema, donde la demencia que se activa con el régimen militar ya parece estar instalada en la sociedad que lo origina y que ahora simplemen...

  1. Off to the Post Office

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Whether you want to send a Christmas card to your family,ship some items back home or receive a birthday present from your loved ones,you will need to go to the post office or use one of the express mail providers that operate in China. Sending letters or parcels,domestically or internationally,is pretty straightforward in China.As long as you know what kind of service you are looking for,and the rules that need to be followed,you should not run into any problems.Here are some tips to help make this process easier.

  2. Post-Secularism, Religious Knowledge and Religious Education

    Science.gov (United States)

    Carr, David

    2012-01-01

    Post-secularism seems to follow in the wake of other (what are here called) "postal" perspectives--post-structuralism, postmodernism, post-empiricism, post-positivism, post-analytical philosophy, post-foundationalism and so on--in questioning or repudiating what it takes to be the epistemic assumptions of "modernism." To be sure, post-secularism…

  3. [Post-Lyme disease syndrome].

    Science.gov (United States)

    Błaut-Jurkowska, Justyna; Jurkowski, Marcin

    2016-02-01

    Lyme disease is a chronic infectious disease caused by the bacteria, spirochete of the Borrelia type. Skin, nervous system, musculoskeletal system and heart may be involved in the course of the disease. The prognosis for properly treated Lyme disease is usually good. However, in about 5% of patients so called Post-Lyme disease syndrome (PLSD) develops. It is defined as a syndrome of subjective symptoms persisting despite proper treatment of Borrelia burgdorferi infection. The most common symptoms include: fatigue, muscle and joint pain, and problems with memory and concentration. Pathogenesis of PLDS remains unknown. The differential diagnosis should include neurological, rheumatic and mental diseases. Till now there is no causative treatment of PLDS. In relieving symptom rehabilitation, painkillers, anti-inflammatory and antidepressants medicines are recommended. Emotional and psychological supports are also necessary. Non-specific symptoms reported by patients with post- Lyme disease syndrome raise the suspicion of other pathologies. This can lead to misdiagnosis and implementation of unnecessary, potentially harmful to the patient's therapy. An increase in tick-borne diseases needs to increase physicians awareness of these issues. PMID:27000820

  4. Sterile post-traumatic immunosuppression.

    Science.gov (United States)

    Islam, Md Nahidul; Bradley, Benjamin A; Ceredig, Rhodri

    2016-04-01

    After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. This local immune response involves complex interactions between resident cells such as macrophages and dendritic cells, soluble mediators such as cytokines and chemokines, and recruited cells such as neutrophils, monocytes and mesenchymal stromal cells. If of sufficient magnitude, these initial immune responses nevertheless have systemic consequences resulting in a state called post-traumatic immunosuppression (PTI). However, controversy exists regarding the exact immunological changes occurring in systemic compartments triggered by these local immune responses. PTI is one of the leading causes of post-surgical mortality and makes patients vulnerable to hospital-acquired infections, multiple organ failure and many other complications. In addition, hemorrhage, blood transfusion, immunesenescence and immunosuppressant drugs aggravate PTI. PTI has been intensively studied, but published results are frequently cloudy. The purpose of this review is to focus on the contributions made by different responsive modalities to immunosuppression following sterile trauma and to try to integrate these into an overall scheme of PTI. PMID:27195120

  5. Post-Newtonian cosmological models

    CERN Document Server

    Sanghai, Viraj A A

    2015-01-01

    We construct a framework to probe the effect of non-linear structure formation on the large-scale expansion of the universe. We take a bottom-up approach to cosmological modelling by splitting our universe into cells. The matter content within each cell is described by the post-Newtonian formalism. We assume that most of the cell is in the vicinity of weak gravitational fields, so that it can be described using a perturbed Minkowski metric. Our cells are patched together using the Israel junction conditions. We impose reflection symmetry across the boundary of these cells. This allows us to calculate the equation of motion for the boundary of the cell and, hence, the expansion rate of the universe. At Newtonian order, we recover the standard Friedmann-like equations. At post-Newtonian orders, we obtain a correction to the large-scale expansion of the universe. Our framework does not depend on the process of averaging in cosmology. As an example, we use this framework to investigate the cosmological evolution ...

  6. Post-transplantation diabetes mellitus

    Directory of Open Access Journals (Sweden)

    N Zbiti

    2012-01-01

    Full Text Available To determine the prevalence of post-kidney transplantation diabetes (PTDM and to assess its risk factors, we retrospectively studied 92 non-diabetic kidney transplant patients. The immunosuppressive drugs used to prevent rejection included prednisone, a calcineurin inhibitor (cyclosporine or tacrolimus and an antimetabolite (azathioprine or mycofenolate mofetil. Diabetes was defined according to the WHO criteria and the American Diabetes Association. The mean age of our patients was 35.8 ± 10.5 years, and there was a clear male predominance (56 men and 36 women. The graft was from living related donor in 71/92 (76% patients. The prevalence of dia-betes in post-kidney transplant was 15.2%. The factors increasing the occurrence of PTDM included advanced age, high doses of steroids and cyclosporine. Management of PTDM included diet modification, oral anti-diabetic and insulin. We conclude that the prevalence of PTDM is significant in our transplant population and risk factors for its development are multiple and require aggressive multifaceted management.

  7. CERN at the Post Office

    CERN Multimedia

    2006-01-01

    In collaboration with CERN and the Conseil général de l'Ain, the French postal services of the Pays de Gex have released a new set of pre-paid envelopes paying tribute to CERN. The envelopes, which come in packets of ten, each featuring a different aspect of CERN, will be on sale from 6 June onwards. They will be available from five post offices in the Pays de Gex (Ferney-Voltaire, Prévessin-Moëns, Saint-Genis-Pouilly, Thoiry and CERN-Prévessin), as well as from the CERN Shop (Reception, Building 33). The envelopes were unveiled at an official ceremony on 23 May, which was attended by Jocelyne Boch, Vice-President of the Conseil général de l'Ain and Mayoress of Thoiry, as well as Marina Combe, Head of the Saint-Genis-Pouilly, Thoiry and CERN-Prévessin post offices, and Maximilian Metzger, CERN's Secretary-General. The last set of envelopes to feature CERN, which commemorated the Laboratory's 50th anniversary in 2004, were a huge success, with sales totalling 35 000 in less than a year. 'We received...

  8. Immunochemical characterization of the O antigens of two Proteus strains, O8-related antigen of Proteus mirabilis 12 B-r and O2-related antigen of Proteus genomospecies 5/6 12 B-k, infecting a hospitalized patient in Poland.

    Science.gov (United States)

    Drzewiecka, Dominika; Shashkov, Alexander S; Arbatsky, Nikolay P; Knirel, Yuriy A

    2016-05-01

    A hospitalized 73-year-old woman was infected with a Proteus mirabilis strain, 12 B-r, isolated from the place of injection of a blood catheter. Another strain, 12 B-k, recognized as Proteus genomospecies 5 or 6, was isolated from the patient's faeces, which was an example of a nosocomial infection rather than an auto-infection. Serological investigation using ELISA and Western blotting showed that strain 12 B-k from faeces belonged to the Proteus O2 serogroup. Strain 12 B-r from the wound displayed cross-reactions with several Proteus O serogroups due to common epitopes on the core or O-specific parts of the lipopolysaccharide. Studies of the isolated 12 B-r O-specific polysaccharide by NMR spectroscopy revealed its close structural similarity to that of Proteus O8. The only difference in 12 B-r was the presence of an additional GlcNAc-linked phosphoethanolamine residue, which creates a putative epitope responsible for the cross-reactivity with Pt. mirabilis O16. The new O-antigen form could appear as a result of adaptation of the bacterium to a changing environment. On the basis of the data obtained, we suggest division of the O8 serogroup into two subgroups: O8a for strains of various Proteus species that have been previously classified into the O8 serogroup, and O8a,b for Pt. mirabilis 12 B-r, where 'a' is a common epitope and 'b' is a phosphoethanolamine-associated epitope. These findings further confirm serological and structural heterogeneity of O antigens of Proteus strains isolated lately from patients in Poland. PMID:26959528

  9. [Post-dural puncture headache].

    Science.gov (United States)

    Radke, K; Radke, O C

    2013-02-01

    Headache following dural puncture is a typical complication of neuraxial analgesia and can impair the ability to perform activities of daily living up to incapacitation. The use of thin, atraumatic needles and special puncture techniques (e.g. reinsertion of the stylet) can prevent the majority of post-dural puncture headaches (PDPH). One of the most effective measures to prevent headache after accidental dural puncture is the intrathecal or epidural administration of morphine. When the diagnosis of PDPH is confirmed after excluding relevant differential diagnoses, some of which are potentially life-threatening, caffeine, theophylline and non-opioid analgesics are effective agents to reduce the severity of the symptoms. Traditional measures, such as strict bed rest and hyperhydration can no longer be recommended. If invasive treatment of the headache is warranted an epidural blood patch is still the method of choice with a high rate of success. PMID:23400710

  10. Post Mortem et Tony Manero

    OpenAIRE

    Urrutia, Carolina

    2015-01-01

    Post Mortem, troisième long-métrage de Pablo Larraín, pourrait être le prélude du film précédent, Tony Manero ; le moment où le protagoniste (joué dans les deux cas par Alfredo Castro) tombe dans la folie sans retour et devient psychopathe. Le pari des deux films est extrême, car il assume la représentation et la relecture d’une époque extrême, où la démence mise en action sous le régime militaire semble être déjà installée dans la société qui lui donne naissance. Cette folie ne fait plus qu’...

  11. Post-Newtonian quasirigid body

    International Nuclear Information System (INIS)

    In this paper, we construct for the first time, in the first post-Newtonian (1PN) approximation, a complete model of a quasirigid body by means of a new constraint on the mass current density and mass density. In our 1PN quasirigid body model most of the relations, such as the spin vector proportional to the angular velocity, the definition of the moment of inertia tensor, the key relation between the mass quadrupole moment and the moment of inertia tensor, the rigid rotating formulas for the mass quadrupole moment, and the moment of inertia tensor, are just an extension of the main relations in the Newtonian rigid body model. When all of the 1/c2 terms are neglected, the 1PN quasirigid body model and the corresponding formulas reduce to the Newtonian version. A key relation is obtained in this paper for the first time, which might be very useful in future applications to problems in geodynamics and astronomy

  12. Post irradiation maxillary sinus sarcoma

    International Nuclear Information System (INIS)

    Radiation-induced cancer of the head and neck is well known, but radiation-induced sarcoma is rare. Only nine cases have been reported in the Japanese literature. We treated a patient with post irradiation sarcoma arising in the maxillary sinus. She is now 60 years old and had received radiation therapy for left maxillary carcinoma in 1952. In 1972, left maxillary sarcoma was found and she received postoperative radiation therapy again. Then right nasal carcinoma was found in 1980, and she again received postoperative radiation therapy. Then left maxillary sarcoma was found in 1992. There have been no previous reports of three consecutive radiation-induced malignancies developing in a patient. (author)

  13. Post-therapeutic imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Pollice, Saverio, E-mail: saveriopollice@hotmail.it [Department of Radiology and Neuroradiology, “L. Bonomo Hospital”, 76123 Andria, BT (Italy); Muto, Mario, E-mail: mutomar@tiscali.it [Department of Neuroradiology, “Cardarelli Hospital”, Naples (Italy); Scarabino, Tommaso, E-mail: tscarabino@hotmail.com [Department of Radiology and Neuroradiology, “L. Bonomo Hospital”, 76123 Andria, BT (Italy)

    2015-05-15

    Highlights: • This study is the result of collaboration between neuroradiologists and neurosurgeons. • Comparison between neuroimaging techniques to better evaluate the complications after treatment of the spin. • Evaluation of the imaging features of complications and definition of follow-up. - Abstract: Any surgical approach modifies the normal anatomical and functional arrangement of the segmental spine which is aimed, therefore image interpretation cannot ignore a correct set of knowledge in the field of anatomy, pathophysiology, drug compliance, interventional radiology and surgery. Neuroradiological imaging has an important role before surgery to direct the surgeon or interventional radiologist during the operation, both in post-surgery, where imaging examination can rightly evaluate properties and effects of the treatment and can detect potential complications as infections, abscess, bleeding, exuberant scar, mobilization and rupture of devices. The available methods of imaging are the X-rays (XR) made at least in two projections, Computed Tomography (CT) with MPR (multiplanar) and VR (volume rendering) reconstruction, and Magnetic Resonance (MR), often performed before and after contrast media injection. Imaging assessment of spine after surgery is complex and depends upon several factors, including surgical procedures and disease for which it was performed; biomechanical of the underlying cortical and cancellous bone findings; conditions of muscles, intervertebral disk and ligaments; time since surgery procedures; duration and nature of the post-surgical syndrome. Depending upon several factors, one or a combination of complementary imaging modalities (X-rays, Computed Tomography, Magnetic Resonance) may be required to evaluate effectiveness of the treatment; to demonstrate any clinically relevant abnormality at the treated region and adjacent structures (complications such as inflammation, abscesses, bleeding and misplacement of the device); to

  14. Gynecologic Malignancies Post-LeFort Colpocleisis

    Directory of Open Access Journals (Sweden)

    Rayan Elkattah

    2014-01-01

    Full Text Available Introduction. LeFort colpocleisis (LFC is a safe and effective obliterative surgical option for older women with advanced pelvic organ prolapse who no longer desire coital activity. A major disadvantage is the limited ability to evaluate for post-LFC gynecologic malignancies. Methods. We present the first case of endometrioid ovarian cancer diagnosed after LFC and review all reported gynecologic malignancies post-LFC in the English medical literature. Results. This is the second reported ovarian cancer post-LFC and the first of the endometrioid subtype. A total of nine other gynecologic malignancies post-LFC have been reported in the English medical literature. Conclusions. Gynecologic malignancies post-LFC are rare. We propose a simple 3-step strategy in evaluating post-LFC malignancies.

  15. Post-acquisition integration: a buyer's perspective

    OpenAIRE

    Partio, Merja

    2012-01-01

    This study examines a post-acquisition integration case. The buyer’s perspective was selected to understand the post-acquisition integration and value creation during the process. I was interested in the micro level activities by the people involved in the cross-cultural integration. This study seeks to understand the post-acquisition integration case and discover the implementation during the process: implementation actions, their impact as well as integration success, which relates back to ...

  16. [Post-traumatic stress disorder after childbirth].

    Science.gov (United States)

    Korábová, I; Masopustová, Z

    2016-01-01

    The aim of this paper is to introduce the issue of post-traumatic stress disorder after childbirth to health care professionals. The text focuses on the diagnostic definition of post-traumatic stress disorder after childbirth, symptoms, physiological background, prevalence, course, risk factors and consequences of post-traumatic stress disorder after childbirth for a woman, her child and her partner. Options for interventions and therapy are outlined as well. PMID:26982058

  17. Equine post-breeding endometritis: A review

    OpenAIRE

    Maischberger, Eva; Irwin, J A; Carrington, S D; Duggan, V E

    2008-01-01

    The deposition of semen, bacteria and debris in the uterus of the mare after breeding normally induces a self-limiting endometritis. The resultant fluid and inflammatory products are cleared by 48 hours post cover. Mares that are susceptible to persistent post-breeding endometritis (PPBEM) have impaired uterine defence and clearance mechanisms, making them unable to resolve this inflammation within the normal time. This persists beyond 48 hours post-breeding and causes persistent fluid accumu...

  18. A post-processor for Gurmukhi OCR

    Indian Academy of Sciences (India)

    G S Lehal; Chandan Singh

    2002-02-01

    A post-processing system for OCR of Gurmukhi script has been developed. Statistical information of Punjabi language syllable combinations, corpora look-up and certain heuristics based on Punjabi grammar rules have been combined to design the post-processor. An improvement of 3% in recognition rate, from 94.35% to 97.34%, has been reported on clean images using the post-processing techniques.

  19. Post-socialist city development in Tirana

    OpenAIRE

    Abitz, Julie

    2006-01-01

    #Abstract This thesis surveys how city development is contested in post-socialist Tirana, Albania. It explores how different actors contest city development in Tirana and how the concept of community informs their work. Furthermore, this study explores how socialist city development informs post-socialistic city development. Contestations in post-socialist city development are studied through a theoretical framework formed by a combination of two theoretical approaches: A discursive gover...

  20. PRIMIPARA POST PARTUM DEPRESSION DIAGNOSIS AND TREATMENT

    OpenAIRE

    Esha Pradnyana; Wayan Westa; Nyoman Ratep

    2013-01-01

    Pregnancy and the first child birth is an influential complex event for a mother, which is where everything including phsycal and psyological aspects. This change can make mother psyological disorder, that can lead into depression after childbearing that call post childbearing depression or post partum depression. A wide review at 59 study make a result that 13% among primipara can suffer post partum depression 12 weeks after childbearing. Estabilishmet of this diagnosis, besides from history...

  1. Image Post-Processing in Dental Practice

    OpenAIRE

    Gormez, Ozlem; Yilmaz, Hasan Huseyin

    2009-01-01

    Image post-processing of dental digital radiographs, a function which used commonly in dental practice is presented in this article. Digital radiography has been available in dentistry for more than 25 years and its use by dental practitioners is steadily increasing. Digital acquisition of radiographs enables computer-based image post-processing to enhance image quality and increase the accuracy of interpretation. Image post-processing applications can easily be practiced in dental office by ...

  2. In vitro evaluation of glass fiber post

    OpenAIRE

    Kaur, Jasjit; Sharma, Navneet; Singh, Harpal

    2012-01-01

    Statement of problem: Techniques and recommendations for the restoration of endodontically treated teeth have changed from the use of custom cast metal post and core system to glass fiber-reinforced (GFRC) post and composite core system. Has this latest prefabricated glass fiber reinforced post and composite core system increased the fracture resistance of teeth and reduced the incidence of unrestorable root fractures. Purpose: The purpose of this study was to evaluate the incidence of root f...

  3. Equine post-breeding endometritis: A review

    OpenAIRE

    Maischberger E; Irwin JA; Carrington SD; Duggan VE

    2008-01-01

    Abstract The deposition of semen, bacteria and debris in the uterus of the mare after breeding normally induces a self-limiting endometritis. The resultant fluid and inflammatory products are cleared by 48 hours post cover. Mares that are susceptible to persistent post-breeding endometritis (PPBEM) have impaired uterine defence and clearance mechanisms, making them unable to resolve this inflammation within the normal time. This persists beyond 48 hours post-breeding and causes persistent flu...

  4. Prevention of Post-ERCP Pancreatitis

    OpenAIRE

    Donnellan, F.; Byrne, Michael F

    2011-01-01

    Post-procedure pancreatitis is the most common complication of endoscopic retrograde cholangio pancreatography (ERCP) and carries a high morbidity and mortality occurring in at least 3%-5% of all procedures. We reviewed the available literature searching for “ERCP” and “pancreatitis” and “post-ERCP pancreatitis”. in PubMed and Medline. This review looks at the diagnosis, risk factors, causes and methods of preventing post-procedure pancreatitis. These include the evidence for patient selectio...

  5. A Review of Post and Core Application with Emphasize on Non Metallic Posts

    Directory of Open Access Journals (Sweden)

    Shahroodi MH

    2001-05-01

    Full Text Available Many different methods are suggested to restore endodontically treated teeth. Prefabricated posts can not be indicated for all teeth and cast posts require extra time and cost. In addition, with the introduction of full ceramic restorations, achieving the ideal esthetic with metal post underneath them may be problematic or impossible because the darkness of the metallic posts may show through the highly translucent all ceramic restorations. In this article the review of litature and describiton of applied methods of different procedure in restoring the root canal therapied teeth and few techniques of non metallic posts fabrication such as fiber reinforced composite and zirconium oxide posts have been described.

  6. History education in post-conflict societies

    Directory of Open Access Journals (Sweden)

    Sirkka Ahonen

    2014-06-01

    Full Text Available This article studies the reconciliatory potential of history education in post-conflict societies. History education today is understood through post-colonial, multiperspectival studies, which in a post-conflict society contribute to reconciliation by fostering critical thinking, being inclusive in regard to different social groups, and recognising the local, vernacular history culture. The article compares three cases of post-conflict history education, derived from Finland, Bosnia-Herzegovina and South Africa. It concludes by considering the nature of feasible teaching processes and the role of different educational actors.

  7. Post-Human Body and Beauty

    OpenAIRE

    Maria Teresa Russo; Nicola Di Stefano

    2014-01-01

    El artículo pone en duda la posibilidad misma de una estética post-humana, a partir de la siguiente premisa: en lugar de post-humano, es más correcto hablar de post-natural, indicando con esta expresión una realidad producida a través de un nuevo tipo de evolución, que no cambia simplemente la naturaleza humana, sino que la des-naturaliza, transformándola radicalmente en artefacto. Esta post-naturaleza, que aspira a ser perfecta, inmortal, invulnerable, es totalmente carente de belleza. De he...

  8. MRO DKF Post-Processing Tool

    Science.gov (United States)

    Ayap, Shanti; Fisher, Forest; Gladden, Roy; Khanampompan, Teerapat

    2008-01-01

    This software tool saves time and reduces risk by automating two labor-intensive and error-prone post-processing steps required for every DKF [DSN (Deep Space Network) Keyword File] that MRO (Mars Reconnaissance Orbiter) produces, and is being extended to post-process the corresponding TSOE (Text Sequence Of Events) as well. The need for this post-processing step stems from limitations in the seq-gen modeling resulting in incorrect DKF generation that is then cleaned up in post-processing.

  9. Microleakage of Different Post Systems and a Custom Adapted Fiber Post

    Directory of Open Access Journals (Sweden)

    Farideh Geramipanah

    2013-01-01

    Full Text Available Objective: The effects of closely adapting a prefabricated fiber to the post space remain unknown. The purpose of this study was to quantify the microleakages of a custom adapted fiber-reinforced post, a prefabricated quartz fiber post and a cast post using nondestructive methods.Materials and Methods: Sixty-five extracted human premolars were endodontically treated and randomly divided into three groups (n=15, which were restored using a cast post-and-core, a custom adapted fiber post (Refropost with a microhybrid microfiller resin composite (Gradia, or a prefabricated quartz fiber post (DT light post and two groups of control ( n=10. All groups were cemented using a dual polymerizing resin cement (Panavia F2.0. A composite core (Z100 was used for the fiber posts. The microleakage was calculated for the experimental and control groups before and after thermal cycling and cycling loading using a radiotracer solution (thallium 201 chloride and a gamma counter device. Data were subjected to statistical analysis of ANOVA and Tukey HSD at significant level of P< 0.05.Results: Significantly lower microleakage values were found for the cast post-and-core (mean value =16.04 ×104 and custom adapted fiber post groups (mean value=14.36×104. Thermal cycling and cyclic loading had no significant effect on the microleakage value of any tested group.Conclusion: Post systems with improved adaptation showed similar microleakage to casting post

  10. Post Pelvic Radiotherapy Bony Changes

    Energy Technology Data Exchange (ETDEWEB)

    Huh, Seung Jae [Samsung Medical Center, Seoul (Korea, Republic of)

    2009-03-15

    There has been recent interest in radiation-induced bone injury in clinical conditions, especially for pelvic insufficiency fracture (PIF). A PIF is caused by the effect of normal or physiological stress on bone with demineralization and decreased elastic resistance. Pelvic radiotherapy (RT) can also contribute to the development of a PIF. A PIF has been regarded as a rare complication with the use of megavoltage equipment. However, recent studies have reported the incidence of PIFs as 8.2{approx}20% after pelvic RT in gynecological patients, an incidence that was higher than previously believed. The importance of understanding a PIF lies in the potential for misdiagnosis as a bony metastasis. If patients complain of pelvic pain after whole-pelvis radiation therapy, the presence of a PIF must be considered in the differential diagnosis. The use of multibeam arrangements and conformal RT to reduce the volume and dose of irradiated pelvic bone can be helpful to minimize the risk of fracture. In addition to a PIF, osteonecrosis and avascular necrosis of the femoral head can develop after radiation therapy. Osteoradionecrosis of the pelvic bone is a clinical diagnostic challenge that must be differentiated from an osseous metastasis. A post-radiation bone sarcoma can result as a long-term sequela of pelvic irradiation for uterine cervical cancer.

  11. Post partum pelvic floor changes.

    Science.gov (United States)

    Fonti, Ylenia; Giordano, Rosalba; Cacciatore, Alessandra; Romano, Mattea; La Rosa, Beatrice

    2009-10-01

    Pelvic-perineal dysfunctions, are the most common diseases in women after pregnancy. Urinary incontinence and genital prolapsy, often associated, are the most important consequences of childbirth and are determined by specific alterations in the structure of neurological and musculo-fascial pelvic support.Causation is difficult to prove because symptom occur remote from delivery.Furthermore it is unclear whether changes are secondary to the method of childbirth or to the pregnancy itself.This controversy fuels the debate about whether or not women should be offered the choice of elective caesarean delivery to avoid the development of subsequent pelvic floor disfunction.But it has been demonstrated that pregnancy itself, by means of mechanical changes of pelvic statics and changes in hormones, can be a significant risk factor for these diseases. Especially is the first child to be decisive for the stability of the pelvic floor.During pregnancy, the progressive increase in volume of the uterus subject perineal structures to a major overload. During delivery, the parties present and passes through the urogenital hiatus leading to growing pressure on the tissues causing the stretching of the pelvic floor with possible muscle damage, connective tissue and / or nervous.In this article we aim to describe genitourinary post partum changes with particular attention to the impact of pregnancy or childbirth on these changes. PMID:22439048

  12. Comparison of transcriptomic signature of post-Chernobyl and post radiotherapy thyroid tumors

    International Nuclear Information System (INIS)

    We previously identified two highly discriminating and predictive radiation-induced transcriptomic signatures by comparing series of sporadic and post radiotherapy thyroid tumors (322-gene signature), and by reanalyzing a previously published data set of sporadic and post-Chernobyl thyroid tumors (106-gene signature). The aim of the present work was (i) to compare the two signatures in terms of gene expression de-regulations and molecular features/pathways, and (ii) to test the capacity of the post radiotherapy signature in classifying the post-Chernobyl series of tumors and reciprocally of the post-Chernobyl signature in classifying the post radiotherapy-induced tumors. We now explored if post radiotherapy and post-Chernobyl papillary thyroid carcinomas (PTC) display common molecular features by comparing molecular pathways deregulated in the two tumor series, and tested the potential of gene subsets of the post radiotherapy signature to classify the post-Chernobyl series (14 sporadic and 12 post-Chernobyl PTC), and reciprocally of gene subsets of the post-Chernobyl signature to classify the post radiotherapy series (15 sporadic and 12 post radiotherapy PTC), by using conventional principal component analysis. We found that the five genes common to the two signatures classified the learning/training tumors (used to search these signatures) of both the post radiotherapy (seven PTC) and the post-Chernobyl (six PTC) thyroid tumor series as compared with the sporadic tumors (seven sporadic PTC in each series). Importantly, these five genes were also effective for classifying independent series of post radiotherapy (five PTC) and post-Chernobyl (six PTC) tumors compared to independent series of sporadic tumors (eight PTC and six PTC respectively; testing tumors). Moreover, part of each post radiotherapy (32 genes) and post-Chernobyl signature (16 genes) cross-classified the respective series of thyroid tumors. Finally, several molecular pathways deregulated in post

  13. Post-emergence herbicides useful in calendula

    Science.gov (United States)

    Easy and effective weed control is required by growers who are considering new industrial crops. Post-emergence herbicides typically are the products of choice by today’s growers. Unfortunately, post-emergence herbicides with proven safety margins are not known for calendula (Calendula officinalis),...

  14. Patients' quality of life post thyroidectomy.

    LENUS (Irish Health Repository)

    Cashman, E C

    2011-01-01

    This study was designed to evaluate health related quality of life post thyroidectomy for hyperthyroidism with respect to clinical benefit and patient satisfaction. This is one of the first such studies in the literature evaluating quality of life post thyroidectomy for hyperthyroidism.

  15. The Review of China Post's Informationizing Constructing

    Institute of Scientific and Technical Information of China (English)

    WANG Wei-min; DU Yu-wei; SUN Hao

    2005-01-01

    The article briefly introduces the three stages that China Post experienced and the circumstances of the fundamental network construction, focusing on introducing the three sorts of services based on postal comprehensive computer network's applicable software system: postal financial service; traditional service electrified; electronic postal service. Finally the thinking for future China Post's informationizing constructing is put forward.

  16. 77 FR 58592 - Modified Norway Post Agreement

    Science.gov (United States)

    2012-09-21

    ... Modified Norway Post Agreement AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recently-filed Postal Service request to include a modified Norway Post Agreement... existing bilateral agreement for inbound competitive services with Posten Norge AS (Modified Norway...

  17. Atrial fibrillation post cardiac bypass surgery

    OpenAIRE

    Mostafa, Ashraf; EL-Haddad, Mohamed A.; Shenoy, Maithili; Tuliani, Tushar

    2012-01-01

    Atrial fibrillation occurs in 5-40% patients after coronary artery bypass graft surgery. Atrial fibrillation increases mortality and morbidity in the post-operative period. We sought to conduct a comprehensive review of literature focusing on pathophysiology, risk factors, prevention and treatment of post coronary artery bypass graft atrial fibrillation.

  18. Retention of Root Canal Posts: Effect of Cement Film Thickness, Luting Cement, and Post Pretreatment.

    Science.gov (United States)

    Sahafi, A; Benetti, A R; Flury, S; Peutzfeldt, A

    2015-01-01

    The aim of this study was to investigate the effect of the cement film thickness of a zinc phosphate or a resin cement on retention of untreated and pretreated root canal posts. Prefabricated zirconia posts (CosmoPost: 1.4 mm) and two types of luting cements (a zinc phosphate cement [DeTrey Zinc] and a self-etch adhesive resin cement [Panavia F2.0]) were used. After removal of the crowns of 360 extracted premolars, canines, or incisors, the root canals were prepared with a parallel-sided drill system to three different final diameters. Half the posts did not receive any pretreatment. The other half received tribochemical silicate coating according to the manufacturer's instructions. Posts were then luted in the prepared root canals (n=30 per group). Following water storage at 37°C for seven days, retention of the posts was determined by the pull-out method. Irrespective of the luting cement, pretreatment with tribochemical silicate coating significantly increased retention of the posts. Increased cement film thickness resulted in decreased retention of untreated posts and of pretreated posts luted with zinc phosphate cement. Increased cement film thickness had no influence on retention of pretreated posts luted with resin cement. Thus, retention of the posts was influenced by the type of luting cement, by the cement film thickness, and by the post pretreatment. PMID:25764045

  19. Retention of Root Canal Posts: Effect of Cement Film Thickness, Luting Cement, and Post Pretreatment

    DEFF Research Database (Denmark)

    Sahafi, Alireza; Benetti, Ana Raquel; Peutzfeldt, Anne; Flury, Simon

    2015-01-01

    The aim of this study was to investigate the effect of the cement film thickness of a zinc phosphate or a resin cement on retention of untreated and pretreated root canal posts. Prefabricated zirconia posts (CosmoPost: 1.4 mm) and two types of luting cements (a zinc phosphate cement [DeTrey Zinc...

  20. Interventional Treatment for Post-traumatic Headache.

    Science.gov (United States)

    Conidi, Francis X

    2016-06-01

    Post-traumatic headache (migraine) is the most common symptom of concussion and traumatic brain injury. An expert opinion-based review along with a literature review (PubMed) was conducted looking at known interventional procedures for post-traumatic headache using the keywords post-traumatic headache, post-traumatic migraine headache, concussion, mild traumatic brain injury, and traumatic brain injury and the following categories: mechanism, pathophysiology, treatment, physical therapy, neurostimulation, Botox@/Onabotulinum toxin, and surgical intervention. The results returned a total of 181 articles of which 52 were selected. None of the articles included randomized placebo-controlled studies, and most were either prospective or retrospective case analysis and/or review articles or consensus opinion papers, with most studies yielding positive results. Despite a lack of hard evidence, interventional procedures, alone or in combination, appear to be an effective treatment for post-traumatic headaches. PMID:27130542

  1. Post-Retrofit Residential Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Lancaster, Ross; lutzenhiser, Loren; Moezzi, Mithra; Widder, Sarah H.; Chandra, Subrato; Baechler, Michael C.

    2012-04-30

    This study examined a range of factors influencing energy consumption in households that had participated in residential energy-efficiency upgrades. The study was funded by a grant from the U.S. Department of Energy’s Pacific Northwest National Laboratory and was conducted by faculty and staff of Portland State University Center for Urban Studies and Department of Economics. This work was made possible through the assistance and support of the Energy Trust of Oregon (ETO), whose residential energy-efficiency programs provided the population from which the sample cases were drawn. All households in the study had participated in the ETO Home Performance with Energy Star (HPwES) program. A number of these had concurrently pursued measures through other ETO programs. Post-retrofit energy outcomes are rarely investigated on a house-by-house basis. Rather, aggregate changes are ordinarily the focus of program impact evaluations, with deviation from aggregate expectations chalked up to measurement error, the vagaries of weather and idiosyncrasies of occupants. However, understanding how homes perform post-retrofit on an individual basis can give important insights to increase energy savings at the participant and the programmatic level. Taking a more disaggregated approach, this study analyzed energy consumption data from before and after the retrofit activity and made comparisons with engineering estimates for the upgrades, to identify households that performed differently from what may have been expected based on the estimates. A statistical analysis using hierarchal linear models, which accounted for weather variations, was performed looking separately at gas and electrical use during the periods before and after upgrades took place. A more straightforward comparison of billing data for 12-month periods before and after the intervention was also performed, yielding the majority of the cases examined. The later approach allowed total energy use and costs to be

  2. Explosive signatures: Pre & post blast

    Science.gov (United States)

    Bernier, Evan Thomas

    Manuscripts 1 and 2 of this dissertation both involve the pre-blast detection of trace explosive material. The first manuscript explores the analysis of human hair as an indicator of exposure to explosives. Field analysis of hair for trace explosives is quick and non-invasive, and could prove to be a powerful linkage to physical evidence in the form of bulk explosive material. Individuals tested were involved in studies which required handling or close proximity to bulk high explosives such as TNT, PETN, and RDX. The second manuscript reports the results of research in the design and application of canine training aids for non-traditional, peroxide-based explosives. Organic peroxides such as triacetonetriperoxide (TATP) and hexamethylenetriperoxidediamine (HMTD) can be synthesized relatively easily with store-bought ingredients and have become popular improvised explosives with many terrorist groups. Due to the hazards of handling such sensitive compounds, this research established methods for preparing training aids which contained safe quantities of TATP and HMTD for use in imprinting canines with their characteristic odor. Manuscripts 3 and 4 of this dissertation focus on research conducted to characterize pipe bombs during and after an explosion (post-blast). Pipe bombs represent a large percentage of domestic devices encountered by law enforcement. The current project has involved the preparation and controlled explosion of over 90 pipe bombs of different configurations in order to obtain data on fragmentation patterns, fragment velocity, blast overpressure, and fragmentation distance. Physical data recorded from the collected fragments, such as mass, size, and thickness, was correlated with the relative power of the initial device. Manuscript 4 explores the microstructural analysis of select pipe bomb fragments. Shock-loading of the pipe steel led to plastic deformation and work hardening in the steel grain structure as evidenced by optical microscopy and

  3. Trzy generacje postępowania administracyjnego a Kodeks postępowania administracyjnego

    OpenAIRE

    Ćwiklińska, Marta

    2015-01-01

    Javier Barnes wyróżnił trzy generacje postępowania administracyjnego. Niniejszy esej będzie próbą analizy Kodeksu postępowania administracyjnego pod kątem trzech generacji postępowania administracyjnego. Pierwsza generacja jest najstarsza. Jest to postępowanie orzecznicze, czyli klasyczne postępowanie administracyjne. Organy administracji publicznej wydają formalne decyzje adresowane do indywidualnego adresata. Model ten w anglosaskiej literaturze określany jest jako command and control. Kode...

  4. Development of new radiopaque glass fiber posts.

    Science.gov (United States)

    Furtos, Gabriel; Baldea, Bogdan; Silaghi-Dumitrescu, Laura

    2016-02-01

    The aim of this study was to analyze the radiopacity and filler content of three experimental glass fiber posts (EGFP) in comparison with other glass/carbon fibers and metal posts from the dental market. Three EGFP were obtained by pultrusion of glass fibers in a polymer matrix based on 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]propane (bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA) monomers. Using intraoral sensor disks 27 posts, as well as mesiodistal sections of human molar and aluminum step wedges were radiographed for evaluation of radiopacity. The percentage compositions of fillers by weight and volume were investigated by combustion analysis. Two EGFP showed radiopacity higher than enamel. The commercial endodontic posts showed radiopacity as follows: higher than enamel, between enamel and dentin, and lower than dentin. The results showed statistically significant differences (p b 0.05)when evaluatedwith one-way ANOVA statistical analysis. According to combustion analyses, the filler content of the tested posts ranges between 58.84wt.% and 86.02wt.%. The filler content of the tested EGFP ranged between 68.91 wt.% and 79.04 wt.%. EGFP could be an alternative to commercial glass fiber posts. Futureglass fiber posts are recommended to present higher radiopacity than dentin and perhaps ideally similar to or higher than that of enamel, for improved clinical detection. The posts with a lower radiopacity than dentin should be considered insufficiently radiopaque. The radiopacity of some glass fiber posts is not greatly influenced by the amount of filler. PMID:26652441

  5. Post-dengue encephalopathy and Parkinsonism.

    Science.gov (United States)

    Fong, Choong Yi; Hlaing, Chaw Su; Tay, Chee Geap; Ong, Lai Choo

    2014-10-01

    Parkinsonism as a neurologic manifestation of dengue infection is rare with only 1 reported case in an adult patient. We report a case of a 6-year-old child with self-limiting post-dengue encephalopathy and Parkinsonism. This is the first reported pediatric case of post-dengue Parkinsonism and expands the neurologic manifestations associated with dengue infection in children. Clinicians should consider the possibility of post-dengue Parkinsonism in children with a history of pyrexia from endemic areas of dengue. PMID:24776518

  6. Post-genomics and skin inflammation.

    Science.gov (United States)

    Braconi, Daniela; Bernardini, Giulia; Santucci, Annalisa

    2010-01-01

    Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the most common skin disorders involving inflammatory processes, seems to be still quite neglected under the post-genomic point of view. In this paper, we will review how post-genomic technologies have provided new fundamental tools for the analysis of these three conditions and we will cast light on their potential in addressing future research challenges. PMID:20886018

  7. Post-myelogram headache - physiological or psychological?

    International Nuclear Information System (INIS)

    Psychological aspects of post-lumbar puncture headache have hitherto received little attention. A hundred consecutive patients admitted for elective myelography were studied. Post-myelogram headache was assessed by an independent observer and found to be strongly associated with normality of the test (P<0.001). Psychological testing showed a trend between Hospital Anxiety Depression score and normality of myelogram as well as development of headache, although this did not achieve statistical significance. This study suggestet that there is a large psychological as well as organic component to post-myelogram headache. (orig.)

  8. Survival rate and failure characteristics for two post designs.

    Science.gov (United States)

    Torbjörner, A; Karlsson, S; Odman, P A

    1995-05-01

    The dental records of 638 patients treated with 788 posts and cores were studied to analyze failure rate and failure characteristics for two post designs. Frequency of the technical failures, loss of retention, root fracture, and post fracture were recorded 4 to 5 years after post cementation. There were two types of posts: custom-cast tapered posts and parallel-sided serrated posts. The cumulative failure rate was 15% for 456 tapered posts and 8% for 332 Para-Post posts. Loss of retention was the most frequent reason for failure for both types of posts, whereas root fractures had the most serious consequences, and all resulted in extraction. A significantly higher success rate was recorded for parallel-sided serrated posts, compared with custom-cast posts, regarding the total failure rate and the severity of the failure (p < 0.05). PMID:7658393

  9. Post-traumatic Stress Disorder

    Directory of Open Access Journals (Sweden)

    M Yadollahie

    2011-12-01

    Full Text Available Unexpected extreme sudden traumatic stressor may cause post-traumatic stress disorder (PTSD. Important traumatic events include war, violent personal assault (e.g., sexual assault, and physical attack, being taken hostage or kidnapped, confinement as a prisoner of war, torture, terrorist attack, severe car accidents, and natural disasters. In childhood age sexual abuse or witnessing serious injuries or unexpected death of a beloved one are among important traumatic events.PTSD can be categorized into two types of acute and chronic PTSD: if symptoms persist for less than three months, it is termed “acute PTSD,” otherwise, it is called “chronic PTSD.” 60.7% of men and 51.2% of women would experience at least one potentially traumatic event in their lifetime. The lifetime prevalence of PTSD is significantly higher in women than men. Lifetime prevalence of PTSD varies from 0.3% in China to 6.1% in New Zealand. The prevalence of PTSD in crime victims are between 19% and 75%; rates as high as 80% have been reported following rape. The prevalence of PTSD among direct victims of disasters was reported to be 30%–40%; the rate in rescue workers was 10%–20%. The prevalence of PTSD among police, fire, and emergency service workers ranged from 6%–32%. An overall prevalence rate of 4% for the general population, the rate in rescue/recovery occupations ranged from 5% to 32%, with the highest rate reported in search and rescue personnel (25%, firefighters (21%, and workers with no prior training for facing disaster. War is one of the most intense stressors known to man. Armed forces have a higher prevalence of depression, anxiety disorders, alcohol abuse and PTSD. High-risk children who have been abused or experienced natural disasters may have an even higher prevalence of PTSD than adults.Female gender, previous psychiatric problem, intensity and nature of exposure to the traumatic event, and lack of social support are known risk factors for work

  10. PEP (Post-Exposure Prophylaxis) 101

    Science.gov (United States)

    ... AIDS PEP Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir PEP (post-exposure prophylaxis) means taking antiretroviral medicines (ART) after being potentially exposed to HIV to prevent ...

  11. Proteomic analysis of post-translational modifications

    DEFF Research Database (Denmark)

    Mann, Matthias; Jensen, Ole N

    2003-01-01

    Post-translational modifications modulate the activity of most eukaryote proteins. Analysis of these modifications presents formidable challenges but their determination generates indispensable insight into biological function. Strategies developed to characterize individual proteins are now syst...

  12. Post-Treatment Lyme Disease Syndrome

    Science.gov (United States)

    ... FAQ Health care providers Educational materials Post-Treatment Lyme Disease Syndrome Recommend on Facebook Tweet Share Compartir ... ONE 7(1): e29914. HHS Special Webinar on Lyme Disease Persistence frame support disabled and/or not ...

  13. PRIMIPARA POST PARTUM DEPRESSION DIAGNOSIS AND TREATMENT

    Directory of Open Access Journals (Sweden)

    Esha Pradnyana

    2013-02-01

    Full Text Available Pregnancy and the first child birth is an influential complex event for a mother, which is where everything including phsycal and psyological aspects. This change can make mother psyological disorder, that can lead into depression after childbearing that call post childbearing depression or post partum depression. A wide review at 59 study make a result that 13% among primipara can suffer post partum depression 12 weeks after childbearing. Estabilishmet of this diagnosis, besides from history and symptoms, and can be supported through test Edinburgh Postnatal Depression Scale( EPDS . Patient with post partum depression, given treatment with antidepressant drug. Breastfeeding is not only to reduce stress for the mother, but also reduce the level of stress on a baby when his mother suffered depression

  14. Postpartum Post-Traumatic Stress Disorder

    Science.gov (United States)

    ... with PSI Learn More Pregnancy & Postpartum Mental Health Depression During Pregnancy & Postpartum Anxiety During Pregnancy & Postpartum Pregnancy or Postpartum Obsessive Symptoms Postpartum Post-Traumatic Stress Disorder Bipolar Mood Disorders Postpartum Psychosis Tools for ...

  15. Business Education in Post Soviet Countries

    OpenAIRE

    Doghonadze, Natela

    2009-01-01

    The presented article discusses the history of business education development in post Soviet countries. It is shown that, though much has been done in these countries to bring business education to international standards, still much has to be done

  16. Post-processing speech recordings during MRI

    OpenAIRE

    Kuortti, Juha; Malinen, Jarmo; Ojalammi, Antti

    2015-01-01

    We discuss post-processing of speech that has been recorded during Magnetic Resonance Imaging (MRI) of the vocal tract. Such speech recordings are contaminated by high levels of acoustic noise from the MRI scanner. Also, the frequency response of the sound signal path is not flat as a result of severe restrictions on recording instrumentation due to MRI technology. The post-processing algorithm for noise reduction is based on adaptive spectral filtering. The speech material consists of sample...

  17. Post-Retrieval Extinction Attenuates Cocaine Memories

    OpenAIRE

    Sartor, Gregory C.; Aston-Jones, Gary

    2013-01-01

    Recent studies have shown that post-retrieval extinction training attenuates fear and reward-related memories in both humans and rodents. This noninvasive, behavioral approach has the potential to be used in clinical settings to treat maladaptive memories that underlie several psychiatric disorders, including drug addiction. However, few studies to date have used a post-retrieval extinction approach to attenuate addiction-related memories. In the current study, we attempted to disrupt cocaine...

  18. Congo: Evaluating the Post-Conflict state

    OpenAIRE

    De Boeck, Filip

    2009-01-01

    The objective of this seminar is to bring researchers, experts and policy-makers together and discuss the nature of the post-conflict Congolese state. Discussions will focus on a number of critical issues, including security governance, management of natural resources, local peace efforts and external interventions. Programme Day 1: The process of state building 9.15-9.30 Introduction 9.30-11.00 Panel 1: Evaluating the post-conflict state Speakers: Jean Omasombo – Royal Mus...

  19. Historical approaches to post-combat disorders

    OpenAIRE

    Jones, Edgar

    2006-01-01

    Almost every major war in the last century involving western nations has seen combatants diagnosed with a form of post-combat disorder. Some took a psychological form (exhaustion, combat fatigue, combat stress reaction and post-traumatic stress disorder), while others were characterized by medically unexplained symptoms (soldier's heart, effort syndrome, shell shock, non-ulcer dyspepsia, effects of Agent Orange and Gulf War Syndrome). Although many of these disorders have common symptoms, the...

  20. Post-Keynesianism meets feminist economics

    OpenAIRE

    van Staveren, I.P.

    2010-01-01

    textabstractThis article explores the relationships between post-Keynesian economics and feminist economics. It distinguishes three key concepts in each tradition that recommend serious attention in the other tradition: gender, the household and unpaid work and caring as key concepts in feminist economics; uncertainty, market power and endogenous dynamics as core concepts in post-Keynesian economics. This article will show, with reference to the literature in which such cross-fertilisation ha...

  1. Fatigue in Older Adults Post Myocardial Infarction

    OpenAIRE

    Patricia Barton Crane; Jimmy eEfird; Willie Mae Abel

    2016-01-01

    Objective. The purpose of this study was to comprehensively examine putative factors that may independently contribute to fatigue and subsequent persistence of fatigue in elderly adults 6-8 months post myocardial infarction (MI). Studies suggest cardiac function, comorbidities, daytime sleepiness, depression, anemia, interleukins, and social support are correlates of fatigue; however, no studies have systematically examined these factors 6 months post MI in an aging population. Methods. Study...

  2. Teaching Post Keynesian Exchange Rate Theory

    OpenAIRE

    John Harvey

    2006-01-01

    The goal of this paper is to provide a model and method for those wishing to include the Post Keynesian perspective when teaching exchange rate theory. It begins by reviewing neoclassical approaches (purchasing power parity, the monetary model, and the Dornbusch model) and then develops a graphical Post Keynesian model that is based on Keynes's Z-D diagram, endogenous money, a currency market driven by portfolio capital flows, and no assumption of a tendency toward full employment or balanced...

  3. Cantilever steel post damaged by wind

    Directory of Open Access Journals (Sweden)

    Wei Sha

    2014-10-01

    Full Text Available An analysis for the cause of fracture failure of a cantilever steel sign post damaged by wind has been carried out. An unusual cause of failure has been identified, which is the subject of this paper. Microscopy and microanalysis of the fracture surface showed that the failure was due to pre-existing cracks, from the fabrication of the post. This conclusion was reached after detecting and analysing a galvanised layer on the fracture surfaces.

  4. NASA thesaurus combined file postings statistics

    Science.gov (United States)

    1993-01-01

    The NASA Thesaurus Combined File Postings Statistics is published semiannually (January and July). This alphabetical listing of postable subject terms contained in the NASA Thesaurus is used to display the number of postings (documents) indexed by each subject term from 1968 to date. The postings totals per item are separated by announcement of other media into STAR, IAA, COSMIC, and OTHER, columnar entries covering the NASA document collection (1968 to date). This is a cumulative publication, and except for special cases, no reference is needed to previous issuances. Retention of the January 1992 issue could be helpful for book information. With the July 1992 issue, NALNET book statistics have been replaced by COSMIC statistics for NASA funded software. File postings statistics for the Alternate Data Base covering NASA collection from 1962 through 1967 were published on a one-time basis in September 1975. Subject terms for the Alternate Data Base are derived from the subject Authority List, reprinted 1985, which is available upon request. The distribution of 19,697,748 postings among the 17,446 NASA Thesaurus terms is tabulated on the last page of the NASA Thesaurus Combined File Postings Statistics.

  5. Post-translational modifications in neurodegeneration

    Directory of Open Access Journals (Sweden)

    Federico Benetti

    2015-12-01

    Full Text Available Post-translational modifications increase proteome functionality for managing all aspects of normal cell biology. They are based on the covalent attachment of functional groups, leading to phosphorylation, acetylation, glycosylation, acylation, ubiquitination, SUMOylation and oxidation of protein targets. Post-translational modifications occur at any step of protein life cycle, modulating in time and space protein folding, subcellular localization and activity. Aberrant post-translational modifications of one or more culprit proteins may lead to neurodegeneration, as shown in paradigmatic neurological disorders such as Alzheimer’s, Parkinson’s and prion diseases. In this review, we report the most important post-translational modifications found in neurodegenerative disorders, illustrating the pathophysiological mechanisms in which they are involved. This work highlights the lack of a global framework of post-translational modifications in terms of complexity and regulation. Therefore, in the next future many efforts are required to describe the interplay existing between post-translational modifications and their combinatorial patterns on protein targets.

  6. Abuse, Post-Traumatic Stress Disorder and Migraine

    Science.gov (United States)

    ... Post Traumatic Stress Disorder and Migraine Print Email Abuse, Post Traumatic Stress Disorder and Migraine ACHE Newsletter ... newsletter by entering your e-mail address below. Abuse, Post-Traumatic Stress Disorder and Migraine Gretchen E. ...

  7. Evaluation of post-surface conditioning to improve interfacial adhesion in post-core restorations

    Directory of Open Access Journals (Sweden)

    Mylswamy Sumitha

    2011-01-01

    Full Text Available Aim : To examine the influence of different post-surface treatments on the interfacial strength between epoxy resin-based fiber posts and methacrylate-based resin composites that are employed as core build-up materials. Materials and Methods : Forty clear posts were divided into four groups of 10 each. The different surface treatments used were etching with alkaline potassium permanganate, 10% hydrogen peroxide, 37% phosphoric acid, and silanization alone. After etching and thorough rinsing, a single layer of silane was applied to the post surface. Then the post was placed in a rectangular plastic matrix and core bulid-up was done using Multi Core, a dual cured composite resin. A slab of uniform thickness, with the post in the center and the core build-up composite on either side was created. The specimens were cut so as to obtain microtensile sticks that were loaded in tension at a cross-head speed of 1 mm/min until failure. The statistical analysis was performed using two-way ANOVA and the paired T test for post-hoc comparisons. Results : The results achieved with potassium permanganate had a significant influence on microtensile interfacial bond strength values with the tested material. Conclusion : Surface chemical treatments of the resin phase of fiber posts enhance the silanization efficiency of the quartz fiber phase, so that the adhesion in the post/core unit may be considered as a net sum of chemical and micromechanical retention.

  8. Marijuana-Related Posts on Instagram.

    Science.gov (United States)

    Cavazos-Rehg, Patricia A; Krauss, Melissa J; Sowles, Shaina J; Bierut, Laura J

    2016-08-01

    Instagram is a highly visual social networking site whose audience continues to grow, especially among young adults. In the present study, we examine marijuana-related content on Instagram to better understand the varied types of marijuana-related social networking occurring on this popular social media platform. We collected 417,561 Instagram posts with marijuana-related hashtags from November 29 to December 12, 2014. We assessed content of a random sample (n = 5000) of these posts with marijuana-related hashtags. Approximately 2136 (43 %) were explicit about marijuana and further analyzed. Of the 2136 marijuana-related posts, images of marijuana were common (n = 1568). Among these 1568 marijuana images, traditional forms (i.e., buds/leaves) were the most common (63 %), followed by some novel forms of marijuana, including marijuana concentrates (20 %). Among the 568 posts that displayed marijuana being ingested, 20 % showed someone dabbing marijuana concentrates. Marijuana-related advertisements were also observed among the 2136 marijuana-related posts (9 %). Our findings signal the promotion of marijuana use in its traditional plant-based form; trendy and novel modes of marijuana ingestion were also endorsed. This content along with the explicit marketing of marijuana that we observed on Instagram have potential to influence social norms surrounding marijuana use. PMID:27262456

  9. Bond strengths of five tapered root posts regarding the post surface

    NARCIS (Netherlands)

    Nergiz, [No Value; Schmage, P; Platzer, U; Ozcan, M

    2002-01-01

    The advantage of tapered passive root posts is their homogenous force transmission without creating stress peaks on the root surface because of their anatomical root form. However, their expected retentive strengths are low compared with the other post systems. The objective of this in vitro study w

  10. 14 CFR 417.415 - Post-launch and post-flight-attempt hazard controls.

    Science.gov (United States)

    2010-01-01

    ... evidence; and (4) Ensuring public safety from hazardous debris, such as plans for recovery and salvage of... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Post-launch and post-flight-attempt hazard controls. 417.415 Section 417.415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

  11. Effectiveness of strength training in post stroke

    International Nuclear Information System (INIS)

    The study was done to evaluate the effectiveness of strength training in post stroke. This was an experimental randomized study, conducted at various Physical Therapy OPD setting areas. Sample n = 30; 3 females and 12 males as experimental group and 3 females and 12 males as control group were selected through probability sampling. Mean age of 57 with middle recovery stage of post stroke were included. Different selected strength training exercises were applied on experimental group to assess spasticity, cadence and manual muscle testing. Result was taken by using Mann - Whiteny U test for outcome measures as in cadence, spasticity and manual muscle testing. The result of two outcome measure shows significant result which means the strength training is more effective than the conventional treatment for post stroke of middle recovery stage. (author)

  12. Translucency of Dental Ceramic, Post and Bracket

    Directory of Open Access Journals (Sweden)

    Yong-Keun Lee

    2015-10-01

    Full Text Available Translucency of dental ceramics, esthetic posts and orthodontic brackets was reviewed. Translucency parameter (TP and contrast ratio (CR are generally used for translucency evaluation. For the evaluation of translucency, two criteria such as the translucency of human teeth (TP = 15–19, 1 mm thick and the visual perceptibility threshold for the translucency difference (∆CR > 0.07 or ∆TP > 2 were used. In ceramics, translucency differences were in the perceptible range depending on the type of material and the thickness. However, variations caused by the difference in the required thickness for each layer by the material and also by the measurement protocols should be considered. As to the translucency of esthetic posts, a significant difference was found among the post systems. Translucency was influenced by the bracket composition and brand, and the differences by the brand were visually perceptible.

  13. Equine post-breeding endometritis: A review.

    Science.gov (United States)

    Maischberger, E; Irwin, Ja; Carrington, Sd; Duggan, Ve

    2008-01-01

    The deposition of semen, bacteria and debris in the uterus of the mare after breeding normally induces a self-limiting endometritis. The resultant fluid and inflammatory products are cleared by 48 hours post cover. Mares that are susceptible to persistent post-breeding endometritis (PPBEM) have impaired uterine defence and clearance mechanisms, making them unable to resolve this inflammation within the normal time. This persists beyond 48 hours post-breeding and causes persistent fluid accumulation within the uterus. Mares with PPBEM have an increased rate of embryonic loss and a lower overall pregnancy rate than those without the condition. To enhance conception rates, mares at high risk need optimal breeding management as well as early diagnosis, followed by the most appropriate treatment. This article reviews the pathogenesis, diagnosis and treatment of PPBEM and the management of affected mares. PMID:21851709

  14. Patient expectancy and post-chemotherapy nausea

    DEFF Research Database (Denmark)

    Colagiuri, Ben; Zachariae, Robert

    2010-01-01

    BACKGROUND: Post-chemotherapy nausea remains a significant burden to cancer patients. While some studies indicate that expecting nausea is predictive of experiencing nausea, there are a number of conflicting findings. PURPOSE: The purpose of this study was to conduct a meta-analytic review to...... determine the strength of the relationship between expectancy and post-chemotherapy nausea. METHODS: The findings from 17 relevant studies (n = 2,400) identified through systematic searches of Medline, PsycInfo, and Cinhal were analyzed using a combination of meta-analytic techniques. RESULTS: Overall......, there was a robust positive association between expectancy and post-chemotherapy nausea (ESr = 0.18, equivalent to Cohen's d = 0.35), suggesting that patients with stronger expectancies experience more chemotherapy-induced nausea. Although weaker associations were found in studies employing multivariate...

  15. Equine post-breeding endometritis: A review

    Directory of Open Access Journals (Sweden)

    Maischberger E

    2008-03-01

    Full Text Available Abstract The deposition of semen, bacteria and debris in the uterus of the mare after breeding normally induces a self-limiting endometritis. The resultant fluid and inflammatory products are cleared by 48 hours post cover. Mares that are susceptible to persistent post-breeding endometritis (PPBEM have impaired uterine defence and clearance mechanisms, making them unable to resolve this inflammation within the normal time. This persists beyond 48 hours post-breeding and causes persistent fluid accumulation within the uterus. Mares with PPBEM have an increased rate of embryonic loss and a lower overall pregnancy rate than those without the condition. To enhance conception rates, mares at high risk need optimal breeding management as well as early diagnosis, followed by the most appropriate treatment. This article reviews the pathogenesis, diagnosis and treatment of PPBEM and the management of affected mares.

  16. [Family experiences post-acute myocardial infarction].

    Science.gov (United States)

    Garcia, Raquel Pötter; Budó, Maria de Lourdes Denardin; Simon, Bruna Sodré; Wünsch, Simone; Oliveira, Stefanie Griebeler; Barbosa, Mariane da Silva

    2013-09-01

    This study aimed to describe the family experiences post-infarction. Qualitative, descriptive and exploratory research, carried out with six families of post-infarction patients. Data collection was conducted in families' homes, in the period of February to May of 2012, through observation and interviews with the family. The software Atlas Ti 6.2 was used to code the interviews and the data were explored with thematic analysis. Two categories emerged "Difficult times": immediate consequence of acute myocardial infarction for the families; and "We reeducate ourselves--we can adapt ourselves": current experience of families. The immediate post-infarction experience is permeated by several feelings, with the need for families to adapt to fit into the needs. The current experience shows changes in families due to the disease. The family is the main responsible for the care giving, although Nursing should exchange and share knowledge. PMID:24344600

  17. Post-Starburst Quasars: Bridging the Gap Between Post-Starburst Galaxies and Quasars

    CERN Document Server

    Cales, Sabrina L

    2015-01-01

    In order to better understand the nature of post-starburst quasars (PSQs) in the context of galaxy evolution, we compare their properties to those of post-starburst galaxies and quasars from appropriately selected samples possessing similar redshift ($z \\sim 0.3$), luminosity ($M_r \\sim -$23), and data quality. We consider morphologies, spectral features, and derived physical properties of the stellar populations and central supermassive black hole. PSQs themselves come in two types: the more luminous AGNs with more luminous post-starburst stellar populations hosted by elliptical galaxies, some which are clearly merger products, and the less luminous systems existing within relatively undisturbed spiral galaxies and possessing signs of a more extended period of star formation. Post-starburst galaxies (PSQs) have elliptical and disturbed/post-merger morphologies similar to those of the more luminous PSQs, display similar spectral properties, but also can have younger stellar populations for a given starburst m...

  18. Post-post-Newtonian deflection of light ray in multiple systems with PPN parameters

    International Nuclear Information System (INIS)

    The post-Newtonian scheme in multiple systems with post-Newtonian parameters presented by Klioner and Soffel is extended to the post-post-Newtonian (PPN) order for light propagation problem in the solar system. Under considering the solar system experiment requirement, a new parameter ε is introduced. This extension does not change the virtue of the scheme on the linear partial differential equations of the potential and vector potential mentioned in previous work. Furthermore, this extension is based on the former work done by Richter and Matzner in one global system theory. As an application, we also consider the deflection of light ray in the global coordinates. And the deflection angle of light ray is obtained with post-Newtonian parameters. (general)

  19. Post Millennium Urban Space Design in Denmark

    DEFF Research Database (Denmark)

    Kiib, Hans

    Hans Kiib Post Millennium Urban Space Design in Denmark - a survey on 100 Danish projects from 2002 – 2010. This article is based on an evaluation of 100 Danish open space projects form 2000 – 2010. The projects was initially proposals from Danish municipalities for the Campaign on Better Open...... agendas on Public Space Design in the period up to the development of these 100 projects. This provide interesting patterns related to the goals and the means of well known European projects. The patterns show a clear movement from classic design inspired form Southern European cities to a more context......: Urban design, open urban spaces, architecture, post millennium design....

  20. Analysis for post irradiation examination: (II)

    International Nuclear Information System (INIS)

    The Post Irradiation Examination Facility (PIEF) which is being constructed at Daeduk Engineering Center, Korea Advanced Energy Research Institute, and is supposed to be operated from the end of 1983 on schedule. This facility will be primarily concerned with the post irradiation examinations on fuel assemblies, fuel rods and the evaluation of reactor material properties. The contents of this report is the research of destructive examinations on nuclear fuels, reactor materials and components at hot laboratory. There are two major areas of investigation. 1. Metallographic examination on irradiated samples. 2. Mechanical and Physical property test on fuel rods and reactor materials. (Author)