The BITBUS Universal Gateway (BUG) provides a unique, cost effective solution to many different computer interface problems. Each BUG node, utilizing ''on board'' intelligence, has the ability to provide a communication link between BITBUS protocol and other computer-signal interfaces. Among them, IEEE-488, RS232, and raw analog and binary signal 1/0. BITBUS is a multidrop, multinode link with the ability to communicate over great distances. By using this method of signal transfer, along with the communication conversion ability of the BUG, one could accomplish such things as the ability to run IEEE-488 instruments over great distances, extend a multidrop links to RS232 instruments, and provide a convenient interface point for remote analog and binary 1/0 signals, all on one homogeneous network. The BUG not only provides this through the wired ''twisted pair'' standard of BITBUS, but extends the ability to fiber optic communications for signal transfer over extreme distances and through electrically ''noisy'' environments
Nawrocki, G.J.; Arnold, N.D.; Hoffberg, M.G.; Winans, J.R.; Benes, S.J.
The Advanced Photon Source (APS) control system is based on a distributed topology of microprocessor-based Input/Output Controllers (IOCs). Since the cost effectiveness of placing an IOC near every point where an interface to the control system is required may be prohibitive, I/O subnets implemented via message passing network protocols are utilized. For greatest flexibility, such a subnet must support connections to equipment via discrete I/O points, connections to standard interfaces such as GPIB and RS232, and be a practical network for custom-designed interfaces to intelligent equipment. This paper describes the BITBUS Universal Gateway (BUG), a device which supports the different interfaces mentioned above with a connection to a single BITBUS distributed subnet. The BUG utilizes an interchangeable set of circuit boards, which allow for a commonality among interface points, and the ability to use commercially-available modules for I/O. This approach also circumvents several limitations of GPIB and RS232, which restrict their use in industrial, electrically harsh environments, via an implementation of the BITBUS protocol over optical fibers
Jansweijer, P.P.M; Hogenbirk, J.J.
For a bitbus system in a raw environment galvanic interfaces are necessary. This report offers various possibilities for implementing such an galvanic interface. One of the possibilities is described in detail. Along the objects to be controlled an apart ringline runs in behalf of the bitbus. The various bitbus components which have been mounted near these objects, are coupled to this ringline via opto-couplers. (author). 6 refs.; 9 figs
Summary of GATEWAY report focuses on four exterior solid-state lighting projects that have been completed at Princeton since 2008, when the University adopted a comprehensive sustainability plan. Through these initial projects – which include a parking garage, a pedestrian path, and two parking lot installations – the school’s facilities engineering staff learned important lessons about SSL technology and gained experience in dealing with the rapidly changing landscape of lighting manufacturers and their suppliers.
Davis, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Evans, WIlliam E. [Princeton Univ., NJ (United States); Murphy, Arthur [Princeton Univ., NJ (United States); Perrin, Tess [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
This report focuses on four exterior solid-state lighting projects that have been completed at Princeton since 2008, when the University adopted a comprehensive sustainability plan. Through these initial projects – which include a parking garage, a pedestrian path, and two parking lot installations – the school’s facilities engineering staff learned important lessons about SSL technology and gained experience in dealing with the rapidly changing landscape of lighting manufacturers and their suppliers.
Adhana Teklr, Kelali
Over last two decades education sector in Ethiopia has got due attention. To meet the education deficit of the nation number of universities has been increased from two to thirty eight and twelve more are coming soon. The proliferation has brought a spillover effect that universities have to compete for center excellence in research and education. Convincingly, government’s support is geared towards knowledge-based and innovation-driven system of education to back up the green economic development plan.In an effort to build inclusive economic development emphasis is given to innovative competency building through science and technology fields. The universities in the nation have establish laboratories to educate school boys and girls at early stage of their schooling in STEM (Science, Technology, Engineering and Mathematics) subjects as means to paving future destiny. Though most of the astronomy and space science labs are virtual ones; more and more student have been inspired and want astronomy and space science as their future career fields. Assessment study carried out in universities running STEM education showed that there is a mismatch between the capacity of the labs and number of students wanted to study astronomy and space sciences. The universities have endorsed that STEM education is the gateway to future astronomy and strongly advised concerned bodies and partnering institutions to collaboratively work to intensify the teaching-learning of STEM subjects.The assessment study compiled astronomic and space science exercises carried out by instructors and students and the document is ready to be disseminated to universities and middle and secondary schools to promote the science nationwide. The results have motivated university instructors, science and technology professionals, researchers and policy makers to be more involved in shaping future destiny of the young generation and have their shown determination to support the STEM education so that it will
Roger E. HAMLIN
Full Text Available World trade and transportation are changing dramatically. Energy prices and transport sustainability concerns are reinvigorating ocean freighter shipping. An ever-increasing portion of trade is in containers, and container ships are getting larger quickly. Many ports, nations and continents are not keeping up with ship size increases putting them at a trade disadvantage. Major canals and seaways must also upgrade or be rendered obsolete, causing a change in the pattern of world trade. Ports have to do more than expand vessel size limits. Port regions must also invest in infrastructure that improves multi-modal access to the port and augments hand-off of containers to smaller seaway ships, trains and trucks. With heightened security and evolving emphasis on flexible and efficient logistics, ports must become high-tech logistics hubs with improved real-time data about port throughput. Constanţa, Romania provides an example of an attempt to respond to this rapid change. Near the Danube Delta, on the Black Sea, Constanţa offers a potential southeastern gateway to Europe for the Black Sea, the Eastern Mediterranean and beyond. Ships from Asia, entering via the Suez Canal can easily access Constanţa, and thus save more than ten days of shipping time for destinations in southeastern Europe compared to shipping through Rotterdam or Hamburg. But Constanţa needs to make all the improvements mentioned above. Universities have several roles in this endeavor, including identifying and forecasting trends, providing the technical knowledge to develop high-tech logistics hubs, pursing publicprivate partnerships for infrastructure development and offering training.
Lv, Ming-Fang; Xie, Li; Song, Xi-Jiao; Hong, Jian; Mao, Qian-Zhuo; Wei, Tai-Yun; Chen, Jian-Ping; Zhang, Heng-Mu
Virion distribution and ultrastructural changes induced by the infection of maize or rice with four different reoviruses were examined. Rice black streaked dwarf virus (RBSDV, genus Fijivirus), Rice ragged stunt virus (RRSV, genus Oryzavirus), and Rice gall dwarf virus (RGDV, genus Phytoreovirus) were all phloem-limited and caused cellular hyperplasia in the phloem resulting in tumors or vein swelling and modifying the cellular arrangement of sieve elements (SEs). In contrast, virions of Rice dwarf virus (RDV, genus Phytoreovirus) were observed in both phloem and mesophyll and the virus did not cause hyperplasia of SEs. The three phloem-limited reoviruses (but not RDV) all induced more flexible gateways at the SE-SE interfaces, especially the non-sieve plate interfaces. These flexible gateways were also observed for the first time at the cellular interfaces between SE and phloem parenchyma (PP). In plants infected with any of the reoviruses, virus-like particles could be seen within the flexible gateways, suggesting that these gateways may serve as channels for the movement of plant reoviruses with their large virions between SEs or between SEs and PP. SE hyperplasia and the increase in flexible gateways may be a universal strategy for the movement of phloem-limited reoviruses.
Pierce, Marlon; Marru, Suresh; Abeysinghe, Eroma; edu, pamidigs iu; Christie, Marcus
The goal of the Science Gateways Platform as a service (SciGaP.org) project is to provide core services for building and hosting science gateways. Over the last two years, SciGaP services have been used to build and host over twenty science gateways. Hosted gateways include campus gateways that focus on providing cyberinfrastructure for university computing facilities, domain gateways that target a particular field of science, and science gateways that provide “software as a service” for newl...
Bingel, Bradford D.
TOAD Gateway is interactive software tool for converting data files to and from variety of file formats. Currently reads and writes following file formats: TOAD; Standard Interface File (SIF); Program to Optimize Simulated Trajectories (POST) input; Comma Separated Value and Tab Separated Value, common in PC and Macintosh spreadsheet and database packages; and general free format. Additional modules for accommodating other formats easily developed and installed. Companion program, TOAD Editor (LAR-14423), manipulates contents of TOAD files and extracts selected subsets of data. TOAD Gateway written in FORTRAN 77.
Pitts, Robert Lee
Goals of this activity: Test the Huntsville Operations Support Center (HOSC) Delay/Disruption Tolerant Networking (DTN) Gateway for operational use Current activity includes: (1) Test the Implementation of a new DTN2 gateway at the HOSC (2) Confirm integration of DTN nodes into the S-band uplink and Ku-band downlink of the ISS for limited use (3) Implement Aggregate Custody Signal to ISS platforms (4) Verify operational support for Colorado University (CU) onboard components (5) Verify ability to support Multi-Purpose End-To- End Robotic Operation Network (METERON) OpsCon-2
Department of Transportation — CDLIS - Gateway is the clearinghouse for CDL information collected by all states, and provides a gateway for enforcement users to access CDL data. CDLIS Gateway was...
"Gateway to the Future" pairs a painting of a gateway constructed from children's building blocks with an ink drawing of a personal symbol on a collaged background. The main objective of this lesson is to create a metaphoric artwork about moving from the present through a symbolic portal to the future. So, space--foreground, middle ground, and…
Starr, J.A.; Steinert, L.A.
A device for sealing a gateway between interconnectable pools in a nuclear facility comprising a frame supporting a liquid impermeable sheet positioned in a u-shaped gateway between the pools. An inflatable tube carried in a channel in the periphery of the frame and adjoining the gateway provides a seal therebetween when inflated. A restraining arrangement on the bottom edge of the frame is releasably engagable with an adjacent portion of the gateway to restrict the movement of the frame in the u-shaped gateway upon inflation of the tube, thereby enhancing the seal. The impermeable sheet is formed of an elastomer and thus is conformable to a liquid permeable supportive wall upon application of liquid pressure to the side of the sheet opposite the wall
Remote Sensing Information Gateway, a tool that allows scientists, researchers and decision makers to access a variety of multi-terabyte, environmental datasets and to subset the data and obtain only needed variables, greatly improving the download time.
Levy, Louise R.
Discusses major features and capabilities of gateway software--microcomputer software packages that act as interfaces between users and bibliographic retrieval systems they are searching--i.e., communication, interface, auxiliary programs. Four programs (In-Search, Universal Online Searcher, Search Helper, microDisclosure) are reviewed and…
Shernof, David J.; Ruzek, Erik A.; Sannella, Alexander J.; Schorr, Roberta Y.; Sanchez-Wall, Lina; Bressler, Denise M.
The purpose of this study was to evaluate a model for considering general and specific elements of student experience in a gateway course in undergraduate Financial Accounting in a large university on the East Coast, USA. Specifically, the study evaluated a bifactor analytic strategy including a general factor of student classroom experience, conceptualized as student engagement as rooted in flow theory, as well as factors representing specific dimensions of experience. The study further evaluated the association between these general and specific factors and both student classroom practices and educational outcomes. The sample of students (N = 407) in two cohorts of the undergraduate financial accounting course participated in the Experience Sampling Method (ESM) measuring students' classroom practices, perceptions, engagement, and perceived learning throughout the one-semester course. Course grade information was also collected. Results showed that a two-level bifactor model fit the data better than two traditional (i.e., non-bifactor) models and also avoided significant multicollinearity of the traditional models. In addition to student engagement (general factor), specific dimensions of classroom experience in the bifactor model at the within-student level included intrinsic motivation, academic intensity, salience, and classroom self-esteem. At the between-student level, specific aspects included work orientation, learning orientation, classroom self-esteem, and disengagement. Multilevel Structural Equation Modeling (MSEM) demonstrated that sitting in the front of the classroom (compared to the sitting in the back), taking notes, active listening, and working on problems during class had a positive effect on within-student variation in student engagement and attention. Engagement, in turn, predicted perceived learning. With respect to between-student effects, the tendency to sit in front seats had a significant effect on student engagement, which in turn had a
Shernof, David J; Ruzek, Erik A; Sannella, Alexander J; Schorr, Roberta Y; Sanchez-Wall, Lina; Bressler, Denise M
The purpose of this study was to evaluate a model for considering general and specific elements of student experience in a gateway course in undergraduate Financial Accounting in a large university on the East Coast, USA. Specifically, the study evaluated a bifactor analytic strategy including a general factor of student classroom experience, conceptualized as student engagement as rooted in flow theory, as well as factors representing specific dimensions of experience. The study further evaluated the association between these general and specific factors and both student classroom practices and educational outcomes. The sample of students ( N = 407) in two cohorts of the undergraduate financial accounting course participated in the Experience Sampling Method (ESM) measuring students' classroom practices, perceptions, engagement, and perceived learning throughout the one-semester course. Course grade information was also collected. Results showed that a two-level bifactor model fit the data better than two traditional (i.e., non-bifactor) models and also avoided significant multicollinearity of the traditional models. In addition to student engagement (general factor), specific dimensions of classroom experience in the bifactor model at the within-student level included intrinsic motivation, academic intensity, salience, and classroom self-esteem. At the between-student level, specific aspects included work orientation, learning orientation, classroom self-esteem, and disengagement. Multilevel Structural Equation Modeling (MSEM) demonstrated that sitting in the front of the classroom (compared to the sitting in the back), taking notes, active listening, and working on problems during class had a positive effect on within-student variation in student engagement and attention. Engagement, in turn, predicted perceived learning. With respect to between-student effects, the tendency to sit in front seats had a significant effect on student engagement, which in turn had
David J. Shernof
Full Text Available The purpose of this study was to evaluate a model for considering general and specific elements of student experience in a gateway course in undergraduate Financial Accounting in a large university on the East Coast, USA. Specifically, the study evaluated a bifactor analytic strategy including a general factor of student classroom experience, conceptualized as student engagement as rooted in flow theory, as well as factors representing specific dimensions of experience. The study further evaluated the association between these general and specific factors and both student classroom practices and educational outcomes. The sample of students (N = 407 in two cohorts of the undergraduate financial accounting course participated in the Experience Sampling Method (ESM measuring students' classroom practices, perceptions, engagement, and perceived learning throughout the one-semester course. Course grade information was also collected. Results showed that a two-level bifactor model fit the data better than two traditional (i.e., non-bifactor models and also avoided significant multicollinearity of the traditional models. In addition to student engagement (general factor, specific dimensions of classroom experience in the bifactor model at the within-student level included intrinsic motivation, academic intensity, salience, and classroom self-esteem. At the between-student level, specific aspects included work orientation, learning orientation, classroom self-esteem, and disengagement. Multilevel Structural Equation Modeling (MSEM demonstrated that sitting in the front of the classroom (compared to the sitting in the back, taking notes, active listening, and working on problems during class had a positive effect on within-student variation in student engagement and attention. Engagement, in turn, predicted perceived learning. With respect to between-student effects, the tendency to sit in front seats had a significant effect on student engagement, which
...) roadmap that used gateways between current and future TDLs. Approval of the roadmap was deferred, pending more information, which is supplied in this TDL Gateway Introduction requested by AF/XPPI...
Deshpande, Alina [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Los Alamos National Laboratory (LANL) is part of that worldwide team and has been developing state of the art information systems to aid the global health community. For instance, in 2014 LANL announced the release of the LANL Biosurveillance (BSV) Gateway. The site provides information about ongoing biosurveillance research projects and capabilities at LANL, and provides access to a host of LANL-developed biosurveillance tools and resources. We are seeking feedback on this gateway and would like to ask interested folk to offer comments and suggestions after they have perused the BSV website.
Reece-Hoyes, John S; Walhout, Albertha J M
The Gateway recombinatorial cloning system was developed for cloning multiple DNA fragments in parallel (e.g., in 96-well formats) in a standardized manner using the same enzymes. Gateway cloning is based on the highly specific integration and excision reactions of bacteriophage λ into and out of the Escherichia coli genome. Because the sites of recombination (" att " sites) are much longer (25-242 bp) than restriction sites, they are extremely unlikely to occur by chance in DNA fragments. Therefore, the same recombination enzyme can be used to robustly clone many different fragments of variable size in parallel reactions. © 2018 Cold Spring Harbor Laboratory Press.
Reece-Hoyes, John S; Walhout, Albertha J M
Generating stocks of Entry and Destination vectors for use in the Gateway recombinatorial cloning system requires transforming them into Escherichia coli strain DB3.1, where they can replicate because this strain is immune to the effects of the ccdB gene carried in the Gateway cassette. However, mutations in the ccdB gene can arise at low frequency, and these mutant plasmids will consequently allow growth of standard cloning strains of E. coli (e.g., DH5α). Therefore, after making new stocks of Gateway plasmids, their ability to grow in cloning strains of E. coli must be tested. This involves obtaining multiple stocks of vector, each arising from a single plasmid grown in a single DB3.1 bacterial colony, and transforming each stock into both DB3.1 and the preferred cloning strain of E. coli in a controlled fashion. Only vector stocks that effectively kill the standard cloning strain (i.e., no or few colonies are obtained after transformation) should be used in Gateway cloning reactions. The sequence can be performed in 3 d. © 2018 Cold Spring Harbor Laboratory Press.
Wang, Shin-Ywan; Burleigh, Scott C.
The Remote Asynchronous Message Service (RAMS) gateway is a special-purpose AMS application node that enables exchange of AMS messages between nodes residing in different AMS "continua," notionally in different geographical locations. JPL s implementation of RAMS gateway functionality is integrated with the ION (Interplanetary Overlay Network) implementation of the DTN (Delay-Tolerant Networking) bundle protocol, and with JPL s implementation of AMS itself. RAMS protocol data units are encapsulated in ION bundles and are forwarded to the neighboring RAMS gateways identified in the source gateway s AMS management information base. Each RAMS gateway has interfaces in two communication environments: the AMS message space it serves, and the RAMS network - the grid or tree of mutually aware RAMS gateways - that enables AMS messages produced in one message space to be forwarded to other message spaces of the same venture. Each gateway opens persistent, private RAMS network communication channels to the RAMS gateways of other message spaces for the same venture, in other continua. The interconnected RAMS gateways use these communication channels to forward message petition assertions and cancellations among themselves. Each RAMS gateway subscribes locally to all subjects that are of interest in any of the linked message spaces. On receiving its copy of a message on any of these subjects, the RAMS gateway node uses the RAMS network to forward the message to every other RAMS gateway whose message space contains at least one node that has subscribed to messages on that subject. On receiving a message via the RAMS network from some other RAMS gateway, the RAMS gateway node forwards the message to all subscribers in its own message space.
Tauscher, K.; Burns, J. O.; Monsalve, R.; Rapetti, D.
We suggest that, with a suitable antenna and receiver, the Deep Space Gateway can be used to measure the highly redshifted, global 21-cm signal from neutral hydrogen, a spectral imprint of the history of the universe onto cosmic background radiation.
Mackie, M.; Burton, P.F.
Internet subject gateways were set up under the Electronic Libraries Programme (eLib) in order to address some of the problems of searching the Internet which have been identified by information professionals, i.e. locating relevant, good quality information. This preliminary study examines the extent to which academics in two universities use three eLib subject gateways (EEVL, OMNI and SOSIG). The results are generally encouraging for the eLib programme, but it is necessary for the gateways ...
Hayden, L. B.; Jackson-Ward, F.
The Science Gateway Institute (SGW-I) for the Democratization and Acceleration of Science was a SI2-SSE Collaborative Research conceptualization award funded by NSF in 2012. From 2012 through 2015, we engaged interested members of the science and engineering community in a planning process for a Science Gateway Community Institute (SGCI). Science Gateways provide Web interfaces to some of the most sophisticated cyberinfrastructure resources. They interact with remotely executing science applications on supercomputers, they connect to remote scientific data collections, instruments and sensor streams, and support large collaborations. Gateways allow scientists to concentrate on the most challenging science problems while underlying components such as computing architectures and interfaces to data collection changes. The goal of our institute was to provide coordinating activities across the National Science Foundation, eventually providing services more broadly to projects funded by other agencies. SGW-I has succeeded in identifying two underrepresented communities of future gateway designers and users. The Association of Computer and Information Science/Engineering Departments at Minority Institutions (ADMI) was identified as a source of future gateway designers. The National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE) was identified as a community of future science gateway users. SGW-I efforts to engage NOBCChE and ADMI faculty and students in SGW-I are now woven into the workforce development component of SGCI. SGCI (ScienceGateways.org ) is a collaboration of six universities, led by San Diego Supercomputer Center. The workforce development component is led by Elizabeth City State University (ECSU). ECSU efforts focus is on: Produce a model of engagement; Integration of research into education; and Mentoring of students while aggressively addressing diversity. This paper documents the outcome of the SGW
This poster offers information about volunteer computing for science gateways that offer high-throughput computing services. Volunteer computing can be used to get computing power. This increases the visibility of the gateway to the general public as well as increasing computing capacity at little cost.
Hartog, F.T.H. den; Balm, M.; Jong, C.M. de; Kwaaitaal, J.J.B.
A new OSI-based model is described that can be used for the classification of residential gateways. It is applied to analyze current gateway solutions and draw evolutionary paths for the medium to long term. From this it is concluded that particularly set-top boxes and broadband modems, as opposed
State-of-the-art robot mapping approaches are capable of acquiring impressively accurate 2D and 3D models of their environments. To the best of our knowledge, few of them represent structure or acquire models of task-relevant objects. In this work, a new approach to mapping of indoor environments is presented, in which the environment structure in terms of regions and gateways is automatically extracted, while the robot explores. Objects, both in 2D and 3D, are modeled explicitly in those map...
E-cigarettes are alleged to be a gateway to cigarette smoking in non-smokers. This study examines whether the gateway theory has value, whether the criteria to establish causality have been met and what type of evidence is required to test this theory. Experiments are impractical, and we may not be able to test properly the gateway effects via observational studies that simply adjust for confounders. Multivariate models cannot eliminate all the variance in propensity to smoke captured by the variable 'vaping' because of the proximity of these two behaviours. It may be difficult to prove that vaping precedes smoking when product use co-occurs and when, in fact, smoking usually precedes vaping. The gateway theory is not compatible with either (1) the decrease in smoking prevalence observed in adolescents in countries where vaping increased or (2) an increase in smoking among teenagers after age restrictions were imposed on e-cigarette purchases. A spurious gateway effect can be produced artificially by mathematical models in which a propensity to use substances is correlated with opportunities to use substances. Finally, neither nicotine medications nor smokeless tobacco produce gateway effects. Available data are compatible with a common liability model in which people who are liable to use nicotine are more likely to use both e-cigarettes and cigarettes. Despite its weaknesses and scant empirical support, the gateway theory of smoking initiation has had enormous political influence. Policies based on this theory will not have the intended effects if the association between vaping and smoking is explained by common liabilities. © 2017 Society for the Study of Addiction.
One of the most difficult tasks in building a full-scope power plant simulator is modelling the plant process computer. For reasons of cost, it is usually not feasible to include a duplicate process computer within the simulator, although this would provide the highest degree of realism. The recent introduction of gateway devices by several process control manufacturers changes the cost picture considerably. These gateways are capable of emulating Input/Output multiplexers and controllers at significantly less cost. Simulators which use these devices can provide the absolute realism of a duplicate process computer without the associated cost burden. This paper discusses the use of gateways in simulators, and examines the case of a simulator now being built which uses this design technique
This paper provides an overview of HTTP, CoAP, AMQP, DDS, MQTT, XMPP communication protocols. The main IoT problem is that IoT devices uses many different communication protocols and devices cannot communicate with each other directly. IoT gateway helps to solve that problem. This paper also identifies requirements for IoT gateway software. Provides solution for communication between devices which are using different messaging architectures. Presents security aspects and ways to secure IoT ga...
Graham, L.; Fries, M.; Hamilton, J.; Landis, R.; John, K.; O'Hara, W.
Use of the Deep Space Gateway provides a hub for a reusable planetary sample return vehicle for missions to gather star dust as well as samples from various parts of the solar system including main belt asteroids, near-Earth asteroids, and Mars moon.
This document provides the software design description for the two core software components, the LVC Gateway, the LVC Gateway Toolbox, and two participants, the LVC Gateway Data Logger and the SAA Processor (SaaProc).
Health literacy, cited as essential to achieving Healthy People 2010's goals to "increase quality and years of healthy life" and to "eliminate health disparities," is defined by Healthy People as "the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions." Accessibility, by definition, the aforementioned "capacity to obtain," thus is health literacy's primary prerequisite. Accessibility's designation as the global gateway to health literacy is predicated also on life's realities: global aging and climate change, war and terrorism, and life-extending medical and technological advances. People with diverse access needs are health professionals' raison d'être. However, accessibility, consummately cross-cultural and universal, is virtually absent as a topic of health promotion and practice research and scholarly discussion of health literacy and equity. A call to action to place accessibility in its rightful premier position on the profession's agenda is issued.
van der Meer, S
The convergence of telecommunications systems and the Internet causes a variety of concepts for service integration. The focus of the recent research studies and the work of several standardization bodies lies mostly on the interworking of services and the universal service access from end-user systems including both fixed and wireless terminals. All approaches are driven by the concept of providing several technologies to users by keeping the peculiarity of each service alive. But, developments should not only concentrate on media adaptation between VoIP and PSTN, but also consider the adaptation among completely different types of applications as for example E- mail, facsimile, or voice. Unified messaging, which is an already accepted service on the market, provides solutions for conversions of different application protocols into each other. The functionality of converting one medium into another is implemented here in so-called media gateways. This paper provides an overview of the current developments in...
logistical planners at the strategic level can anticipate or mitigate the effects of a theater gateway closure on military operations. Through two...the national elements of power was used to find the strategic level effects of the anomaly, that is an unexpected theater gateway closure. It was found...operations. A detailed analysis of the theater gateways location is critical to mitigate or anticipate the sustainment impacts on military operations
One day in February 1991, a man strolling along a bucolic stretch of rural real estate in Alabama heard the call of what he later discovered to be a red-cockaded woodpecker. A rare event, this would ordinarily have been a pleasant surprise. When officials at the Federal Energy Regulatory Commission (FERC) in Washington, D.C., got word of the red's siting, they took notice. And when Dan Mitchell and Jamie Craddock at United Gas Pipe Line Co. in Houston found out, they just shook their heads --- again. The red-cockaded woodpecker is but one of the uniquely named, federally protected species native to South Alabama that Mitchell and Craddock had to constantly concern themselves with as they attempted to ensure the environmental and regulatory compliance of United's recently completed 28-mile Gateway gas pipeline near gas-rich Mobile Bay. Until May 1, when United put Gateway into service, it had taken more than six years to plan and construct the most environmentally correct route for the pipeline. This paper discusses the largest portion of Gateway's route which is piney forest or agricultural land with the wetlands area prevalent in the southern end of the route
Quincy, C. D.; Charles, J. B.; Hamill, Doris; Sidney, S. C.
The NASA Life Sciences Research Capabilities Team (LSRCT) has been discussing deep space research needs for the last two years. NASA's programs conducting life sciences studies - the Human Research Program, Space Biology, Astrobiology, and Planetary Protection - see the Deep Space Gateway (DSG) as affording enormous opportunities to investigate biological organisms in a unique environment that cannot be replicated in Earth-based laboratories or on Low Earth Orbit science platforms. These investigations may provide in many cases the definitive answers to risks associated with exploration and living outside Earth's protective magnetic field. Unlike Low Earth Orbit or terrestrial locations, the Gateway location will be subjected to the true deep space spectrum and influence of both galactic cosmic and solar particle radiation and thus presents an opportunity to investigate their long-term exposure effects. The question of how a community of biological organisms change over time within the harsh environment of space flight outside of the magnetic field protection can be investigated. The biological response to the absence of Earth's geomagnetic field can be studied for the first time. Will organisms change in new and unique ways under these new conditions? This may be specifically true on investigations of microbial communities. The Gateway provides a platform for microbiology experiments both inside, to improve understanding of interactions between microbes and human habitats, and outside, to improve understanding of microbe-hardware interactions exposed to the space environment.
Full Text Available Abstract Background Invitrogen Gateway technology exploits the integrase/att site-specific recombination system for directional cloning of PCR products and the subsequent subcloning into destination vectors. One or three DNA segments can be cloned using Gateway or MultiSite Gateway respectively. A vast number of single-site Gateway destination vectors have been created while MultiSite Gateway is limited to few destination vectors and therefore to few applications. The aim of this work was to make the MultiSite Gateway technology available for multiple biological purposes. Results We created a construct, pDONR-R4-R3, to easily convert any available Gateway destination vector to a MultiSite Gateway vector in a single recombination reaction. In addition, we designed pDONR-R4-R3 so that DNA fragments already cloned upstream or downstream of the Gateway cassette in the original destination vectors can still be utilized for promoter-gene or translational fusions after the conversion. Conclusion Our tool makes MultiSite Gateway a more widely accessible technology and expands its applications by exploiting all the features of the Gateway vectors already available.
Lehtonen, Soili I; Taskinen, Barbara; Ojala, Elina; Kukkurainen, Sampo; Rahikainen, Rolle; Riihimäki, Tiina A; Laitinen, Olli H; Kulomaa, Markku S; Hytönen, Vesa P
Efficient and robust subcloning is essential for the construction of high-diversity DNA libraries in the field of directed evolution. We have developed a more efficient method for the subcloning of DNA-shuffled libraries by employing recombination cloning (Gateway). The Gateway cloning procedure was performed directly after the gene reassembly reaction, without additional purification and amplification steps, thus simplifying the conventional DNA shuffling protocols. Recombination-based cloning, directly from the heterologous reassembly reaction, conserved the high quality of the library and reduced the time required for the library construction. The described method is generally compatible for the construction of DNA-shuffled gene libraries. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: firstname.lastname@example.org.
Background: Use of gateway substances by adolescents usually precedes use of hard substances. Aims: Determine prevalence of use of gateway substances, age at first use and associated factors. Methods: Instruments consisting of sociodemographic variables and alcohol , tobacco, cannabis, stimulant use sections of ...
Discusses subject gateway sites and commercial search engines for the Web and presents an explanation of Google's PageRank algorithm. The principle question addressed is the conditions under which a gateway site will increase the likelihood that a target page is found in search engines. (LRW)
Bromberg, Yérom-David; Réveillère, Laurent; Lawall, Julia
for describing protocol behaviors, message structures, and the gateway logic. Z2z includes a compiler that checks essential correctness properties and produces efficient code. We have used z2z to develop a number of gateways, including SIP to RTSP, SLP to UPnP, and SMTP to SMTP via HTTP, involving a range......The emergence of networked devices in the home has made it possible to develop applications that control a variety of household functions. However, current devices communicate via a multitude of incompatible protocols, and thus gateways are needed to translate between them. Gateway construction......, however, requires an intimate knowledge of the relevant protocols and a substantial understanding of low-level network programming, which can be a challenge for many application programmers. This paper presents a generative approach to gateway construction, z2z, based on a domain-specific language...
System Design for Telecommunication Gateways provides a thorough review of designing telecommunication network equipment based on the latest hardware designs and software methods available on the market. Focusing on high-end efficient designs that challenge all aspects of the system architecture, this book helps readers to understand a broader view of the system design, analyze all its most critical components, and select the parts that best fit a particular application. In many cases new technology trends, potential future developments, system flexibility and capability extensions are outline
The Communications Gateway Software, GATEWAY, provides process-to-process communication between remote applications programs in different protocol domains. Communicating peer processes may be resident on any paired combination of NETEX, DECnet, or TCP/IP hosts. The gateway provides the necessary mapping from one protocol to another and will facilitate practical intermachine communications in a cost effective manner by eliminating the need to standardize on a single protocol or the need to implement multiple protocols in the host computers. The purpose of the gateway is to support data transfers between application programs on different host computers using different protocols. The gateway computer must be physically connected to both host computers and must contain the system software needed to use the communication protocols of both host computers. The communication process between application partners can be divided into three phases: session establishment, data transfer, and session termination. The communication protocols supported by GATEWAY (DECnet, NETEX, and TCP/IP) have addressing mechanisms that allow an application to identify itself and distinguish among other applications on the network. The exact form of the address varies depending on whether an application is passively offering (awaiting the receipt of a network connection from another network application) or actively connecting to another network. When the gateway is started, GATEWAY reads a file of address pairs. One of the address pairs is used by GATEWAY for passively offering on one network while the other address in the pair is used for actively connecting on the other network establishing the session. Now the two application partners can send and receive data in a manner appropriate to their home networks. GATEWAY accommodates full duplex transmissions. Thus, if the application partners are sophisticated enough, they can send and receive simultaneously. GATEWAY also keeps track of the number
... 47 Telecommunication 1 2010-10-01 2010-10-01 false Provider alert gateway requirements. 10.320... System Architecture § 10.320 Provider alert gateway requirements. This section specifies the functions... CMS provider gateways. (a) General. The CMS provider gateway must provide secure, redundant, and...
Agarwal, Deborah A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Faybishenko, Boris [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Freedman, Vicky L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Krishnan, Harinarayan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kushner, Gary [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lansing, Carina [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Porter, Ellen [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Romosan, Alexandru [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Shoshani, Arie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wainwright, Haruko [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Weidmer, Arthur [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wu, Kesheng [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Science data gateways are effective in providing complex science data collections to the world-wide user communities. In this paper we describe a gateway for the Advanced Simulation Capability for Environmental Management (ASCEM) framework. Built on top of established web service technologies, the ASCEM data gateway is specifically designed for environmental modeling applications. Its key distinguishing features include: (1) handling of complex spatiotemporal data, (2) offering a variety of selective data access mechanisms, (3) providing state of the art plotting and visualization of spatiotemporal data records, and (4) integrating seamlessly with a distributed workflow system using a RESTful interface. ASCEM project scientists have been using this data gateway since 2011.
Akre, Christina; Suris, Joan-Carles
Electronic cigarettes (ECs) acting as a gateway to smoking traditional cigarettes (TCs) is a growing public health concern of EC use among youths. To gather the opinions and perceptions of adolescents and young adults (AYAs) on whether and how EC can act as a gateway to smoking TC among youths. A qualitative method included 42 AYAs. Participants identified a significant risk of EC acting as a gateway to TC use, several factors contributing to this phenomenon such as a facilitated transition to smoking or its perception as a harmless toy. Participants considered an even greater gateway threat regarding very young adolescents. A minority did not identify the gateway risk and some believed that it was nicotine-dependent. This potential gateway effect brought forth several recommendations: health professionals should screen adolescents (even very young ones) for EC use and inform consumers of the potential gateway effect; this possible effect should be acknowledged to end the harmless perception many might have; there is an urge for better preventive and regulatory policies directed at protecting adolescents and children who never smoked and support those who have quit. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please email: email@example.com.
Full Text Available Live, Virtual and Constructive (LVC) simulations can share tactical awareness data using command and control (C2) protocol gateways as bridges: Multiple training simulations can be linked to create large scale collaborative environments; simulations...
Spann, James F.
We propose a workshop whose outcome is a publically disseminated product that articulates SMD investigations and HEOMD Life Science research, including international collaborations, that are made possible by the new opportunities in space that result from the Deep Space Gateway.
U.S. Environmental Protection Agency — Use the Environmental Dataset Gateway (EDG) to find and access EPA's environmental resources. Many options are available for easily reusing EDG content in other...
U.S. Environmental Protection Agency — Use the Environmental Dataset Gateway (EDG) to find and access EPA's environmental resources. Many options are available for easily reusing EDG content in other...
Federal Laboratory Consortium — The CINT Gateway to Los Alamos Facility, located at Los Alamos National Laboratory in the center of the Materials Science Complex, brings together materials science...
.... The Human Systems Information Analysis Center (HSIAC) is the gateway to worldwide sources of up-to-date human systems information for designers, engineers, researchers, and number factors specialists...
The EPICS Process Variable Gateway is both a Channel Access Server and Channel Access Client that provides a means for many clients, typically on different subnets, to access a process variable while making only one connection to the server that owns the process variable. It also provides additional access security beyond that implemented on the server. It thus protects critical servers while providing suitably restricted access to needed process variables. The original version of the Gateway worked with EPICS Base 3.13 but required a special version, since the changes necessary for its operation were never incorporated into EPICS Base. Version 2 works with any standard EPICS Base 3.14.6 or later and has many improvements in both performance and features over the older version. The Gateway is now used at many institutions and has become a stable, high-performance application. It is capable of handling tens of thousands of process variables with hundreds of thousands of events per second. It has run for over three months in a production environment without having to be restarted. It has many internal process variables that can be used to monitor its state using standard EPICS client tools, such as MEDM and StripTool. Other internal process variables can be used to stop the Gateway, make several kinds of reports, or change the access security without stopping the Gateway. It can even be started on remote workstations from MEDM by using a Secure Shell script. This paper will describe the new Gateway and how it is used. The Gateway is both a server (like an EPICS Input/Output Controller (IOC)) and a client (like the EPICS Motif Editor and Display Manager (MEDM), StripTool, and others). Clients connect to the server side, and the client side connects to IOCs and other servers, possibly other Gateways. See Fig. 1. There are perhaps three principal reasons for using the Gateway: (1) it allows many clients to access a process variable while making only one connection to
Gámez Díaz, Antonio; Fernández Montes, Pablo; Ruiz Cortés, Antonio
As APIs are becoming popular to build Service-Based Ap- plications (SBA), API Gateways are being increasingly used to facilitate API features management. They o er API management functionalities such as pricing plans support, user authentication, API versioning or response caching. Some parts of the information that an API Gateway needs are already included into a Service Level Agreement (SLA), that providers use to describe the rights and the obligations of involved par- ...
This paper describes a study that was undertaken at the University of Illinois at Urbana-Champaign to compare the databases selected by 75 inexperienced student online searchers aided by an existing gateway system--INFOMASTER, a version of EASYNET--with databases selected manually by four experienced searchers who were reference librarians from…
Sun, Fei; He, Sailing
Considering that previous invisible gateways (an open entrance that only blocks electromagnetic waves) based on super-scatters designed by transformation optics cannot effectively work for narrow beams and light rays that do not touch negative refractive index material, we explore a new way to realize an improved invisible gateway that can give a good performance for both light waves and rays. In all previous invisible gateways, they require a finite thickness of the wall and the gateway. For the improved invisible gateway proposed in this study, there is no requirement on the thickness of the wall and gateway, i.e. the wall and gateway can be infinitely thin. Our study will go a further step to realize the invisible gateway in fiction.
A Gateway to Health Careers for Urban High School Students: Collaborative Front-Line and Allied Workforce Development Program among High Schools, Public Hospitals and Public Colleges. Program Results Report
From 2005 to 2011, the Gateway Institute for Pre-College Education partnered with three public entities in New York City--the Department of Education, the City University of New York and the Health and Hospitals Corporation--to introduce, educate, and prepare urban high school students for careers in the health professions. Gateway was launched in…
Schwandt, Hilary M; Skinner, Joanna; Takruri, Adel; Storey, Douglas
To develop and test an Integrated Gateway Model of behaviors and factors leading to subsequent positive reproductive, maternal, and child health behaviors. A secondary analysis was conducted using previously published household survey data collected from men (n=5551; 2011) and women (n=16144; 2011) in Nigeria and women in Egypt (n=2240; 2004-2007). The number of health behaviors each potential gateway behavior predicted was assessed by multivariate regression, adjusting for potential confounders. The influence of gateway factors on gateway behaviors was tested via interaction terms. Gateway behaviors and factors were ranked by the number of health outcomes predicted, both separately and synergistically. The key gateway behavior identified in both datasets was spousal communication about family planning, whereas the key gateway factor was exposure to family planning messages. The model could facilitate innovative research and programming that in turn might promote cascades of positive behaviors in reproductive, maternal, and child health. Copyright © 2015. Published by Elsevier Ireland Ltd.
Horanyi, M.; Kempf, S.; Malaspina, D.; Poppe, A.; Srama, R.; Sternovsky, Z.; Szalay, J.
A dust instrument onboard the Deep Space Gateway will revolutionize our understanding of the dust environment at 1 AU, help our understanding of the evolution of the solar system, and improve dust hazard models for the safety of crewed and robotic missions.
Jul 1, 2016 ... FRENCH FOR SPECIFIC PURPOSES: THE GATEWAY TO EMPLOYMENT. OPPORTUNITIES FOR NIGERIAN GRADUATES. Nwabueze Joe Obinaju. &. Chukwunonso Hyacinth Muotoo. Abstract. For some years now, accessing jobs after graduation has become a serious issue for Nigerian graduates, their ...
This paper discusses information gateways and equal access to information. Highlights include: the development of the physical infrastructure of libraries; globalization as it relates to the use of software; Internet controls such as the Children's Online Privacy Protection Act; the psycho-social component of libraries; computer literacy and…
Chen, Robert S. (Compiler)
This annual update of the Information Gateway Plan incorporates changes recommended by the Socioeconomic Data and Applications Center (SEDAC) User Working Group (UWG) and reflects comments and suggestions from users, collaborators, and the Contracting Officer Technical Representative (COTR). The Information Gateway Plan is a concise and specific plan that outlines SEDAC activities and services in support of the earth and social sciences and other user communities. The SEDAC Information Gateway effort is a primary means by which the Earth Observing System Data and Information System (EOSDIS) can link meaningfully with a broad range of social science data sources and users in ways that lead to tangible benefits to the American people. The SEDAC Information Gateway provides interdisciplinary access to socioeconomic and physical science data and information resources held by SEDAC and numerous other institutions and networks around the world. The Plan describes the areas of research of earth scientists and socioeconomic scientists where interchange of data and information is most needed. It sets guidelines for the continued development of SEDAC's directory of social science datasets and establishes priorities for efforts to make data held by SEDAC or accessible through SEDAC available to the user community. The Plan also describes the means by which the SEDAC user community can access information products specified by the SEDAC Data and Applications Development Plan (DADP). Among other major activities, SEDAC will continue to enhance and operate a directory capability, interoperable with the Global Change Master Directory, that provides the socioeconomic community with information about earth science products and the earth science research community with information about socioeconomic data. The Information Gateway also serves as a unique and powerful access pathway for a wide range of users and potential users of socioeconomic and earth science data, including
Orcutt, J. A.; Berger, J.; Laske, G.; Babcock, J.
We describe a new technology that can provide real-time telemetry of sensor data from the ocean bottom. The breakthrough technology that makes this system possible is an autonomous surface vehicle called the Wave Glider developed by Liquid Robotics, Inc. of Sunnyvale, CA., which harvests wave and solar energy for motive and electrical power. The free-floating surface communications gateway uses a Liquid Robotics wave glider comprising a surfboard-sized float towed by a tethered, submerged glider, which converts wave motion into thrust. For navigation, the wave glider is equipped with a small computer, a GPS receiver, a rudder, solar panels and batteries, and an Iridium satellite modem. Acoustic communications connect the subsea instruments and the surface gateway while communications between the gateway and land are provided by the Iridium satellite constellation. Wave gliders have demonstrated trans-oceanic range and long-term station keeping capabilities. The topside acoustics communications package is mounted in a shallow tow body, which uses a WHOI micro modem and a Benthos low frequency, directional transducer. A matching bottom side modem and transducer are mounted on the ocean bottom package. Tests of the surface gateway in 4000 m of water demonstrated an acoustic efficiency of approximately 256 bits/J. For example, it has the ability to send four channels of compressed, one sample per second data from the ocean bottom to the gateway with an average power draw of approximately 0.36 W and a latency of about three minutes. This gateway is used to send near-real-time data from a broadband ocean bottom seismic observatory; we are presently designing and constructing a seafloor package with a two-year operational life. We have found that for frequencies f where f~3Hz, the vertical component, seafloor system noise characteristics are generally superior to similar observatories on land. Increasing the density of these stations over the majority of the surface of
Throop, Andrea L.; LaBaer, Joshua
The comprehensive study of protein structure and function, or proteomics, depends on the obtainability of full-length cDNAs in species-specific expression vectors and subsequent functional analysis of the expressed protein. Recombinational cloning is a universal cloning technique based on site-specific recombination that is independent of the insert DNA sequence of interest, which differentiates this method from the classical restriction enzyme-based cloning methods. Recombinational cloning enables rapid and efficient parallel transfer of DNA inserts into multiple expression systems. This unit summarizes strategies for generating expression-ready clones using the most popular recombinational cloning technologies, including the commercially available Gateway® (Life Technologies) and In-Fusion® (Clontech) cloning technologies. PMID:25827088
Tong, H; Papadimitriou, S; Faloutsos, C; Yu, P S; Eliassi-Rad, T
Given a social network, who is the best person to introduce you to, say, Chris Ferguson, the poker champion? Or, given a network of people and skills, who is the best person to help you learn about, say, wavelets? The goal is to find a small group of 'gateways': persons who are close enough to us, as well as close enough to the target (person, or skill) or, in other words, are crucial in connecting us to the target. The main contributions are the following: (a) we show how to formulate this problem precisely; (b) we show that it is sub-modular and thus it can be solved near-optimally; (c) we give fast, scalable algorithms to find such gateways. Experiments on real data sets validate the effectiveness and efficiency of the proposed methods, achieving up to 6,000,000x speedup.
Broadly defined, chemical information science (CIS) covers chemical structure and data analysis including biological activity data as well as processing, organization, and retrieval of any form of chemical information. The CIS Gateway (CISG) of F1000Research was created to communicate research involving the entire spectrum of chemical information, including chem(o)informatics. CISG provides a forum for high-quality publications and a meaningful alternative to conventional journals. This gateway is supported by leading experts in the field recognizing the need for open science and a flexible publication platform enabling off-the-beaten path contributions. This editorial aims to further rationalize the scope of CISG, position it within its scientific environment, and open it up to a wider audience. Chemical information science is an interdisciplinary field with high potential to interface with experimental work.
Lynch, Vickie E.; Chen, Meili; Cobb, John W.; Kohl, James Arthur; Miller, Stephen D.; Speirs, David A.; Vazhkudai, Sudharshan S.
The unique contributions of the Neutron Science TeraGrid Gateway (NSTG) are the connection of national user facility instrument data sources to the integrated cyberinfrastructure of the National Science FoundationTeraGrid and the development of a neutron science gateway that allows neutron scientists to use TeraGrid resources to analyze their data, including comparison of experiment with simulation. The NSTG is working in close collaboration with the Spallation Neutron Source (SNS) at Oak Ridge as their principal facility partner. The SNS is a next-generation neutron source. It has completed construction at a cost of $1.4 billion and is ramping up operations. The SNS will provide an order of magnitude greater flux than any previous facility in the world and will be available to all of the nation's scientists, independent of funding source, on a peer-reviewed merit basis. With this new capability, the neutron science community is facing orders of magnitude larger data sets and is at a critical point for data analysis and simulation. There is a recognized need for new ways to manage and analyze data to optimize both beam time and scientific output. The TeraGrid is providing new capabilities in the gateway for simulations using McStas and a fitting service on distributed TeraGrid resources to improved turnaround. NSTG staff are also exploring replicating experimental data in archival storage. As part of the SNS partnership, the NSTG provides access to gateway support, cyberinfrastructure outreach, community development, and user support for the neutron science community. This community includes not only SNS staff and users but extends to all the major worldwide neutron scattering centers.
...] General Management Plan, Draft Environmental Impact Statement, Gateway National Recreation Area, New... (NPS) is releasing a Draft Environmental Impact Statement (DEIS) for the General Management Plan (GMP), Gateway National Recreation Area (Gateway), New York. The draft describes and analyzes several...
Sabharwal, Lavannya; Kamimura, Daisuke; Meng, Jie; Bando, Hidenori; Ogura, Hideki; Nakayama, Chiemi; Jiang, Jing-Jing; Kumai, Noriko; Suzuki, Hironao; Atsumi, Toru; Arima, Yasunobu; Murakami, Masaaki
The brain-blood barrier (BBB) tightly limits immune cell migration into the central nervous system (CNS), avoiding unwanted inflammation under the normal state. However, immune cells can traverse the BBB when inflammation occurs within the CNS, suggesting a certain signal that creates a gateway that bypasses the BBB might exist. We revealed the inflammation amplifier as a mechanism of this signal, and identified dorsal vessels of the fifth lumber (L5) spinal cord as the gateway. The inflammation amplifier is driven by a simultaneous activation of NF-κB and STATs in non-immune cells, causing the production of a large amount of inflammatory chemokines to open the gateway at L5 vessels. It was found that the activation of the amplifier can be modulated by neural activation and artificially operated by electric pulses followed by establishment of new gateways, Gateway Reflex, at least in mice. Furthermore, genes required for the inflammation amplifier have been identified and are highly associated with various inflammatory diseases and disorders in the CNS. Thus, physical and/or pharmacological manipulation of the inflammation amplifier holds therapeutic value to control neuro-inflammation. © The Authors 2014. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.
Shahand, S.; van Duffelen, J.; Olabarriaga, S. D.
The sustainability of science gateways has been a topic of active discussion because they have been created and supported in the context of temporary research and infrastructure projects. As successful projects come to an end, it is necessary to find (new) models to secure continuous exploitation of
Bazinet, Adam L; Zwickl, Derrick J; Cummings, Michael P
We introduce molecularevolution.org, a publicly available gateway for high-throughput, maximum-likelihood phylogenetic analysis powered by grid computing. The gateway features a garli 2.0 web service that enables a user to quickly and easily submit thousands of maximum likelihood tree searches or bootstrap searches that are executed in parallel on distributed computing resources. The garli web service allows one to easily specify partitioned substitution models using a graphical interface, and it performs sophisticated post-processing of phylogenetic results. Although the garli web service has been used by the research community for over three years, here we formally announce the availability of the service, describe its capabilities, highlight new features and recent improvements, and provide details about how the grid system efficiently delivers high-quality phylogenetic results. © The Author(s) 2014. Published by Oxford University Press, on behalf of the Society of Systematic Biologists.
Shahand, Shayan; Benabdelkader, Ammar; Jaghoori, Mohammad Mahdi; al Mourabit, Mostapha; Huguet, Jordi; Caan, Matthan W. A.; van Kampen, Antoine H. C.; Olabarriaga, Silvia D.
Science gateways provide UIs and high-level services to access and manage applications and data collections on distributed resources. They facilitate users to perform data analysis on distributed computing infrastructures without getting involved into the technical details. The e-BioInfra Gateway is
... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Gateway National Recreation Area. 7.29 Section 7.29 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.29 Gateway National Recreation Area. (a...
... 47 Telecommunication 1 2010-10-01 2010-10-01 false Federal alert gateway. [Reserved] 10.310 Section 10.310 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL MOBILE ALERT SYSTEM System Architecture § 10.310 Federal alert gateway. [Reserved] ...
The psycho-social observation that the use of some psychoactive substances ("drugs") is often followed by the use of other and more problematic drugs has given rise to a cluster of so-called "gateway drug hypotheses," and such hypotheses have often played an important role in developing drug use policy. The current essay suggests that drug use policies that have drawn on versions of the hypothesis have involved an unjustified oversimplification of the dynamics of drug use, reflecting the interests of certain stakeholders rather than wise social policy. The hypothesis should be retired.
Strijkers, R.J.; Norp, A.H.J.
The present invention enables a network operator to select a gateway that provides desirable operational parameters to access a network node function in a network node requested by a client. A network service provider detects what service a client device is requesting or using and selects a gateway
Humphries, P.; Barez, F.; Gowda, A.
The proposed ASMS, Inc. "Flexible Universal Module" is in support of NASA's Deep Space Gateway project. The Flexible Universal Module provides a possible habitation or manufacturing environment in support of Manned Mission for Space Exploration.
Kejser, Ulla Bøgvad
user communities and builds upon our understanding of the requirements, drivers, obstacles and objectives that various stakeholder groups have relating to digital curation. Ultimately, this concept model should provide a critical input to the development and refinement of cost models as well as helping...... and solution providers, and by researchers in follow-up research and development projects. The Framework includes: • A Cost Concept Model—which defines the core concepts that should be included in curation costs models; • An Implementation Guide—for the cost concept model that provides guidance and proposes...... questions that should be considered when developing new cost models and refining existing cost models; • A Gateway Specification Template—which provides standard metadata for each of the core cost concepts and is intended for use by future model developers, model users, and service and solution providers...
Poluri, Krishna Mohan
This brief provides a broad overview of protein-engineering research, offering a glimpse of the most common experimental methods. It also presents various computational programs with applications that are widely used in directed evolution, computational and de novo protein design. Further, it sheds light on the advantages and pitfalls of existing methodologies and future perspectives of protein engineering techniques.
Grunsfeld, J. M.; Siegler, N.; Mukherjee, R.
A starshade is a large external coronagraph which will allow the direct imaging and analysis of planets around nearby stars. We present how the Deep Space Gateway would enable the robotic/astronaut construction of a starshade.
National Aeronautics and Space Administration — This proposal details a novel mobile data transceiver solution that supports standalone wireless sensors and concurrently acts as a gateway between multiple sensor...
Full Text Available Sms Gateway memiliki kemampuan yang bisa dihandalkan guna mendukung sistem informasi manajemen di berbagai bidang. Salah satu contoh penerapan SMS Gateway adalah pada sistem informasi manajamen kepegawaian, dimana sistem kepegawaian bisa dilaksanakan dengan lebih efektif dan efisien dengan dukungan teknologi SMS Gateway. Sebagai proses awal pengolahan data dimulai dengan mendaftarkan pegawai dengan berdasarkan NIP (Nomor Induk Pegawaisebagai kunci pimer dalam database, kemudian dengan NIP yang sudah ersimpan akan dilakukan pengolahan data apakah valid atau tidak NIP yang masuk ke database. Secara otomatis server akan membalas SMS yang masuk secara otomatis tanpa diketikkan secara manual oleh admin. Tugas admin sendiri hanya mengupdate data-data yang mengalami perubahan. Dengan SMS Gateway ini layanan kepegawain bisa menjadi lebih baik dan efisien
Cassady, R. J.; Carberry, C.; Cichan, T.
Human missions to Mars will benefit from precursor missions such as the Deep Space Gateway (DSG) that achieve important science and human health and safety milestones. The DSG can perform lunar science and prepare for future Mars mission science.
U.S. Environmental Protection Agency — Use the Environmental Dataset Gateway (EDG) to find and access EPA's environmental resources. Many options are available for easily reusing EDG content in other...
Peng, Rong; Ding, Lei
In order to realize the access control of wireless gateway and improve the access control of wireless gateway devices, an access control mechanism of SDN architecture which is based on Open vSwitch is proposed. The mechanism utilizes the features of the controller--centralized control and programmable. Controller send access control flow table based on the business logic. Open vSwitch helps achieve a specific access control strategy based on the flow table.
Zolotová, Iveta; Bundzel, Marek; Lojka, Tomáš
Part 2: Open Cloud Computing Architecture for Smart Manufacturing and Cyber Physical Production Systems; International audience; New approaches and technologies like Internet of Things (IoT), cloud computing and Big Data are giving rise to another industrial revolution. We propose here an implementation of an industrial gateway architecture adopting the idea of IoT, intelligent methods, Machine-to-Machine and Cyber-Physical Systems. The proposed gateway creates a virtual representation of the...
St. John, Wallace B.; DuBois, David H.
A digital system provides sending and receiving gateways for HIPPI interfaces. Electronic logic circuitry formats data signals and overhead signals in a data frame that is suitable for transmission over a connecting fiber optic link. Multiplexers route the data and overhead signals to a framer module. The framer module allocates the data and overhead signals to a plurality of 9-byte words that are arranged in a selected protocol. The formatted words are stored in a storage register for output through the gateway.
Lena K Petersen
Full Text Available The generation of DNA constructs is often a rate-limiting step in conducting biological experiments. Recombination cloning of single DNA fragments using the Gateway system provided an advance over traditional restriction enzyme cloning due to increases in efficiency and reliability. Here we introduce a series of entry clones and a destination vector for use in two, three, and four fragment Gateway MultiSite recombination cloning whose advantages include increased flexibility and versatility. In contrast to Gateway single-fragment cloning approaches where variations are typically incorporated into model system-specific destination vectors, our Gateway MultiSite cloning strategy incorporates variations in easily generated entry clones that are model system-independent. In particular, we present entry clones containing insertions of GAL4, QF, UAS, QUAS, eGFP, and mCherry, among others, and demonstrate their in vivo functionality in Drosophila by using them to generate expression clones including GAL4 and QF drivers for various trp ion channel family members, UAS and QUAS excitatory and inhibitory light-gated ion channels, and QUAS red and green fluorescent synaptic vesicle markers. We thus establish a starter toolkit of modular Gateway MultiSite entry clones potentially adaptable to any model system. An inventory of entry clones and destination vectors for Gateway MultiSite cloning has also been established (www.gatewaymultisite.org.
Petersen, Lena K; Stowers, R Steven
The generation of DNA constructs is often a rate-limiting step in conducting biological experiments. Recombination cloning of single DNA fragments using the Gateway system provided an advance over traditional restriction enzyme cloning due to increases in efficiency and reliability. Here we introduce a series of entry clones and a destination vector for use in two, three, and four fragment Gateway MultiSite recombination cloning whose advantages include increased flexibility and versatility. In contrast to Gateway single-fragment cloning approaches where variations are typically incorporated into model system-specific destination vectors, our Gateway MultiSite cloning strategy incorporates variations in easily generated entry clones that are model system-independent. In particular, we present entry clones containing insertions of GAL4, QF, UAS, QUAS, eGFP, and mCherry, among others, and demonstrate their in vivo functionality in Drosophila by using them to generate expression clones including GAL4 and QF drivers for various trp ion channel family members, UAS and QUAS excitatory and inhibitory light-gated ion channels, and QUAS red and green fluorescent synaptic vesicle markers. We thus establish a starter toolkit of modular Gateway MultiSite entry clones potentially adaptable to any model system. An inventory of entry clones and destination vectors for Gateway MultiSite cloning has also been established (www.gatewaymultisite.org).
objective is to utilize the latest field equipment that will be used by the students when they incorporate into the job market place. The GateWay WRT program is always looking for articulation opportunities with four-year universities. Although not all WRT students are interested in pursuing a four-year degree as part of their professional development, some students welcome this opportunity. GateWay WRT program is finalizing articulation agreements with the University of Arizona's Hydrology and Water Resources Program as well as with the Arizona State University Environmental Management program. Also, the WRT program is trying to internationalize its curriculum by establishing contacts with similar programs in other countries. The University of Guanajuato from Mexico has shown interest in exchanging not only students but also faculty through this process. The WRT program puts emphasis in service learning activities by collaborating and helping community groups such the Lindon Park Neighborhood Association and The Environmental Community Outreach Association. Both groups are in charge of disseminating environmental information to the community regarding superfund site issues. The WRT program has supported several paid internships to increase the community awareness on these technical issues.
Savoie, C.; Chu, V.
This article describes how the integration of a new energy management system (EMS) center into Hydro-Quebec`s existing EMS has imposed major changes on its telecommunications environment, including modifications to the existing remote terminal units (RTUs) in its regional SCADA centers. To integrate the different generations of technology, a transputer-based multiserver/multiclient gateway system was designed. (A transputer is a computer that combines a processor, random access memory, and communications links in a single chip. Chips are strung together in hypercube or grid-like patterns to create large parallel processing machines used in scientific, real-time control, and artificial intelligence applications.) The system is characterized by its relatively low cost, powerful processing capacity and compact size. It creates a black-box environment for a multiserver/multiclient structure, with the platforms at either end totally transparent to both clients and servers. The result is a uniform, real-time world viewed by the EMS and SCADAs.
Monica D. Murgia
Full Text Available This article encapsulates my experience of teaching creativity within a higher education curriculum. Creativity often eludes common understanding because it involves using different conceptual streams of thought, often times developing unconsciously and manifesting in the prized “eureka” moment. In 2009, I began explaining the neurological condition of synaesthesia and later introduced this phenomenology in a course designed to cultivate creativity to first year fashion design students. There are many challenges in teaching creativity. Through teaching this course, I discovered that the first challenge is making the students conscious of their own qualitative beliefs on creativity and art. The second is creating exercises to challenge and alter these beliefs, thus forming a new way of thinking and experiencing the world. The most resistance from my students arose when experimenting with non-representational art. They did not have a conscious framework for making and evaluating abstract art. Introducing synaesthesia, a neurologically-based condition that “merges” two or more sensory pathways in the brain, gave my students a framework for discovery. Understanding sensory modalities and ways in which these modalities can blended together in synaesthesia proved to be a gateway to creativity in many of my students. The scope of this article chronicles how I developed my teaching methodology, the results it created in my classroom, as well as its effects on my own artistic practice.
Bayés, M; Rabasseda, X; Prous, J R
Gateways to clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Studies knowledge area of Prous Science Integrity, the drug discovery and devlopment protal, http://integrity.prous.com. This issue focuses on the following selection of drugs: AAV-CF, adalimumab, ademetionine, afeletecan hydrochloride, agomelatine, alemtuzumab, almotriptan, amdoxovir, aplidine, aranose, arsenic sulfide, atazanavir, atlizumab; Bimatoprost, BMS-181176, BMS-188667, bortezomib, bryostatin 1; Combretastatin A-4 phosphate; Darbepoetin alfa, darusentan, deferasirox, desloratadine, DTaP-HBV-IPV/Hib-vaccine, DTI-0009; Eculizumab, edodekin alfa, emtricitabine, enfuvirtide, epoetin, esomeprazole magnesium etoricoxib; Fampridine, fenretinide, FR-146687; Galiximab, gamma-Hydroxybutyrate sodium, ganirelix acetate, gefitinib, Gemtuzumab ozogamicin, gimatecan; HEA125xOKT3, hIL-13-PE38QQR, HSV-2 theracine, Hu14.18-IL-2, human gammaglobulin; Idraparinux sodium, imatinib mesylate, IMiD3, insulin detemir, interleukin-4, irofulven, ISAtx-247; JT-1001; Levetiracetam, levosimendan, liposomal doxorubicin, liposomal vincristine sulfate, lixivaptan, lopinavir, lumiracoxib; Maxacalcitol, melatonin, midostaurin, MLN-518; Neridronic acid, nesiritide, nitronaproxen; Oblimersen sodium, oregovomab; PEG-filgrastim polyglutamate paclitaxel, prasterone, pregabalin; Rosuvastatin calcium, rotigotine hydrochloride; SGN-30; T-1249, tenofovir disoproxil fumarate, teriparatide, tiotropium bromide, tipranavir, TMC-114, trabectedin, transdermal selegiline; UK-427857; Valdecoxib, valganciclovir hydrochloride, vardenafil, vatalanib succinate, vincristine sulfate TCS; Zofenopril calcium.
Report brief summarizing a GATEWAY program evaluation of the long-term performance characteristics (chromaticity change, maintained illuminance, and operations and maintenance) of LED lighting systems in four field installations previously documented in separate DOE GATEWAY reports.
We have been studying about the molecular mechanism responsible for the establishment of the blood-vessel gateway through which immune cells enter the CNS. We have discovered three kinds of gateways in a multiple sclerosis model, EAE, based on the neural stimulations and named them the gravity-gateway reflex, electric-gateway reflex, and pain-gateway reflex, respectively. All gateway reflexes are involved in specific crosstalk between sensory-sympathetic pathways. For example, in the gravity-gateway reflex, gravity-mediated sensory stimulation via the soleus muscles activates fifth lumber(L5)dorsal loot ganglions to activate L5 sympathetic ganglions, which express norepinephrine at specific vessels of the L5 cord. We explain these three types of gateway reflexes in this chapter.
Davis, Tess E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Davis, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wilkerson, Andrea M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
The GATEWAY program evaluated the long-term performance characteristics (chromaticity change, maintained illuminance, and operations and maintenance) of LED lighting systems in four field installations previously documented in separate DOE GATEWAY reports.
The Universe explores the science of what we see in the night sky. Kids will learn about the life cycle of a star, find out how our universe was created, explore nebulae, galaxies, black holes, giant stars and more. Engaging photos, exciting graphics, and a fun quiz at the end of each book will keep them learning. Aligned to Common Core Standards and correlated to state standards. Super Sandcastle is an imprint of Abdo Publishing, a division of ABDO.
Eichhorn, G.; Oliversen, R. (Technical Monitor)
During the last year the US SIMBAD Gateway Project continued to provide services like user registration to the US users of the SIMBAD database in France. Currently there are over 3400 US users registered. We also provide user support by answering questions from users and handling requests for lost passwords when still necessary. We have implemented in cooperation with the CDS SIMBAD project access to the SIMBAD database for US users on an Internet address basis. This allows most US users to access SIMBAD without having to enter passwords. We have maintained the mirror copy of the SIMBAD database on a server at SAO. This has allowed much faster access for the US users. We also supported a demonstration of the SIMBAD database at the meeting of the American Astronomical Society in January. We shipped computer equipment to the meeting and provided support for the demonstration activities at the SIMBAD booth. We continued to improve the cross-linking between the SIMBAD project and the Astrophysics Data System. This cross-linking between these systems is very much appreciated by the users of both the SIMBAD database and the ADS Abstract Service. The mirror of the SIMBAD database at SAO makes this connection faster for the US astronomers. We exchange information between the ADS and SIMBAD on a daily basis. The close cooperation between the CDS in Strasbourg and SAO, facilitated by this project, is an important part of the astronomy-wide digital library initiative called Urania. It has proven to be a model in how different data centers can collaborate and enhance the value of their products by linking with other data centers.
Kirby, Tristan; Barry, Adam E.
Background: The Gateway Drug Theory suggests that licit drugs, such as tobacco and alcohol, serve as a "gateway" toward the use of other, illicit drugs. However, there remains some discrepancy regarding which drug--alcohol, tobacco, or even marijuana--serves as the initial "gateway" drug subsequently leading to the use of…
... Program; Kissimmee Gateway Airport, Kissimmee, FL AGENCY: Federal Aviation Administration, DOT. ACTION... 23, 2011, the FAA approved the Kissimmee Gateway Airport Noise Compatibility Program Update. Some of...'s approval of the Kissimmee Gateway Airport Noise Compatibility Program Update is September 23, 2011...
... Program and Request for Review; Kissimmee Gateway Airport, Kissimmee, FL AGENCY: Federal Aviation... reviewing a proposed Noise Compatibility Program that was submitted for Kissimmee Gateway Airport under the... Gateway Airport were in compliance with applicable requirements effective 12/11/09, and was published in...
...; Comment Request; Student Aid Internet Gateway (SAIG) Enrollment Document AGENCY: Federal Student Aid (FSA... Internet Gateway (SAIG) Enrollment Document. OMB Control Number: 1845-0002. Type of Review: A revision of... Internet Gateway (SAIG) allows eligible entities to securely exchange Title IV, Higher Education Act (HEA...
... 241A 4500060956] Notice of Public Meeting, Gateway West Project Subcommittee of the Boise District... Land Management (BLM) Gateway West Project Subcommittee of the Boise District Resource Advisory Council...) 384-3364. SUPPLEMENTARY INFORMATION: The Gateway West Project Subcommittee advises the Boise District...
... Transmission, Inc.; Notice of Public Scoping Meetings for the Appalachian Gateway Project January 8, 2010. The... assessment (EA) that will discuss the environmental impacts of the Appalachian Gateway Project involving... east coast markets. The Appalachian Gateway Project would consist of the following facilities...
... Gateway Railroad Company-Lease Renewal Exemption-Oklahoma Department of Transportation and Blackwell Industrial Authority Blackwell Northern Gateway Railroad Company (BNGR), a Class III rail carrier, has filed... this line. See Blackwell N. Gateway R.R.--Change in Operators Exemption--Okla. Dep't of Transp. and...
Malone, Patrick S.; Lamis, Dorian A.; Masyn, Katherine E.; Northrup, Thomas F.
The gateway drug model is a popular conceptualization of a progression most substance users are hypothesized to follow as they try different legal and illegal drugs. Most forms of the gateway hypothesis are that "softer" drugs lead to "harder," illicit drugs. However, the gateway hypothesis has been notably difficult to…
... DEPARTMENT OF TRANSPORTATION Maritime Administration [USCG-2003-14294] Gulf Gateway Deepwater Port... Approval of the Gulf Gateway Deepwater Port Decommissioning and License Termination. SUMMARY: The Maritime Administration (MARAD) announces its final clearance and authorization of the decommissioning of the Gulf Gateway...
Fransiska Prihatini Sihotang
Full Text Available Information technology can be utilized in education such as e-Learning and Academic Information System. STMIK GI MDP has applied information technology that provides ease for the dissemination of academic information to students. However, the parents of the students have not obtained the academic information of their children due to the lack of internet-related knowledge. Therefore, this study aims to create a service that is able to convey information to parents directly with SMS Gateway service. This research begins with the collection of user needs through observation techniques and interviews to academic staff and parents. Then performed the required feature analysis. Then the design of SMS Gateway application that will be embedded in existing academic applications and coding system. Gammu is used as a link between applications with mobile phones. The result of this research is the application of SMS Gateway service that can give the student academic information to the parents.
Filgueira, Rosa; Atkinson, Malcom; Bell, Andrew; Main, Ian; Boon, Steve; Meredith, Philp; Kilburn, Christopher
Scientists have always shared data and mathematical models of the phenomena they study. Rock physics and Volcanology, as well as other solid-Earth sciences, have increasingly used Internet communications and computational renditions of their models for this purpose over the last two decades. Here we consider how to organise rock physics and volcanology data to open up opportunities for sharing and comparing both experiment data from experiments, observations and model runs and analytic interpretations of these data. Our hypothesis is that if we facilitate productive information sharing across those communities by using a new science gateway, it will benefit the science. The proposed science gateway should make the first steps for making existing research practices easier and facilitate new research. It will achieve this by supporting three major functions: 1) sharing data from laboratories and observatories, experimental facilities and models; 2) sharing models of rock fracture and methods for analysing experimental data; and 3) supporting recurrent operational tasks, such as data collection and model application in real time. We report initial work in two projects (NERC EFFORT and NERC CREEP-2) and experience with an early web-accessible protytpe called EFFORT gateway, where we are implementing such information sharing services for those projects. 1. Sharing data: In EFFORT gateway, we are working on several facilities for sharing data: *Upload data: We have designed and developed a new adaptive data transfer java tool called FAST (Flexible Automated Streaming Transfer) to upload experimental data and metadata periodically from laboratories to our repository. *Visualisation: As data are deposited in the repository, a visualisation of the accumulated data is made available for display in the Web portal. *Metadata and catalogues: The gateway uses a repository to hold all the data and a catalogue to hold all the corresponding metadata. 2. Sharing models and methods
Lee, Jinkook; Phillips, Drystan; Wilkens, Jenny; Chien, Sandy; Lin, Yu-Chen; Angrisani, Marco; Crimmins, Eileen
International comparisons of disease prevalence have been useful in understanding what proportion of disease might be preventable and in informing potential policy interventions in different cultural and economic contexts. Using newly available, harmonized data from 20 countries, we compare disability and morbidity of older adults between the ages of 55 and 74. The Gateway to Global Aging Data, a data and information portal, provides access to easy-to-use individual-level longitudinal data from 10 surveys covering over 30 countries. Exploiting harmonized measures available from the Gateway, we descriptively examine how disability and morbidity differ across countries. Significant cross-country differences are observed for several health indicators. Comparing countries with the highest and lowest prevalence rates, we observe that hypertension rates vary twofold and stroke rates vary threefold, while disability and arthritis rates vary more than fivefold. Among women, higher gross domestic product and life expectancy are related to lower diabetes, heart disease, and better functioning. Among men, national indicators of economic conditions are not significantly associated with reported disease prevalence. We document substantial heterogeneity in disability and morbidity across countries, separately for men and women and after controlling for population age composition and education. Rich data from various surveys across the world offers remarkable opportunities for cross-country analyses, calling for further investigation of what drives observed differences. The Gateway to Global Aging Data provides easy-to-use harmonized data files and tools to facilitate this type of research. © The Author(s) 2017. Published by Oxford University Press on behalf of The Gerontological Society of America.
Tsetse, Anthony; Appiah-Kubi, Patrick; Loukili, Alae
Internet usage keeps growing daily with global internet traffic expected to quadruple by the end of 2015. This is as mainly due to increasing number of devices connecting to the internet and making data exchange much easier. This growth has impacted the current Internet Protocol version 4 being u...... results indicate a relatively better performance (18%-45%) of the Bare PC gateway compared to a Linux gateway (running the functionalities as standalone systems). We believe the proposed solution could easily scale to wide area networks and also provide a cost efficient solution...
With the widespread application of VoIP, the client with private protocol becomes more and more popular. Skype is one of the representatives. How to connect Skype with PSTN just by Skype client has gradually become hot. This paper design and implement the software based on a kind of USB User Gateway. With the software Skype user can freely communicate with PSTN phone. FSM is designed as the core of the software, and Skype control is separated by the USB Gateway control. In this way, the communication becomes more flexible and efficient. In the actual user testing, the software obtains good results.
... Gateway Railroad Company--Modified Rail Certificate--in Berks County, PA On September 13, 2010, Eastern Berks Gateway Railroad Company (EBGR), a noncarrier, filed a notice for a modified certificate of.... and Blackwell Northern Gateway Railroad--Continuance in Control Exemption--Eastern Berks Gateway...
Vernezze, Michael; Henkel, Marjorie
The Gateway Marketing and Management Association is a local chapter of Delta Epsilon Chi, the postsecondary affiliate of Distributive Education Clubs of America. This vocational student organization provides leadership training and marketing skill development to prepare students for competition at state and national levels. (JOW)
Jan 24, 2012 ... Ethernet and Internet networking systems. For effective implementation of network gateway redundancy, however, ideal focus should .... Router hardware can be made more reliable by adding hot spares, dual power suppliers, and duplicate data paths. But software reliability remains a challenging problem ...
Fitzpatrick, Roberta Bronson
WorldWideScience.org is a Web-based global gateway connecting users to both national and international scientific databases and portals. This column will provide background information on the resource as well as introduce basic searching practices for users.
Torabi, Mohammad R.; Jun, Mi Kyung; Nowicke, Carole; Seitz de Martinez, Barbara; Gassman, Ruth
For the four leading causes of death in the United States (heart disease, cancer, stroke and chronic respiratory disease), tobacco use is a common risk factor. Tobacco use is responsible for almost 450,000 deaths per year and impacts the health of every member of our society. Tobacco is a gateway drug for substance abuse. That role is critical to…
Evidence is mounting that the vast majority of students who are currently placed into prerequisite remedial education could be successful in gateway college-level courses if they receive additional academic support as a corequisite. Recent research on college placement exams reveals that the exams are unreliable at predicting college success, and…
Full Text Available The new South Africa needs information and the CSIR has enabled end-users to search international and local database using an intelligent gateway to provide easy, affordable access to all the well-known hosts. All terminals, Minitels and PCs...
Everyone connected to the Internet is concerned about two basic things: the availability of network services and the speed of the network. Network gateway redundancy technology falls within these categories and happens to be one of the newest technologies which only few companies, such as mobile companies and ...
The Internet has provided advancement in the areas of network and networking facilities. Everyone connected to the Internet is concerned about two basic things: the availability of network services and the speed of the network. Network gateway redundancy technology falls within these categories and happens to be one of ...
The Universe, is one book in the Britannica Illustrated Science Library Series that is correlated to the science curriculum in grades 5-8. The Britannica Illustrated Science Library is a visually compelling set that covers earth science, life science, and physical science in 16 volumes. Created for ages 10 and up, each volume provides an overview on a subject and thoroughly explains it through detailed and powerful graphics-more than 1,000 per volume-that turn complex subjects into information that students can grasp. Each volume contains a glossary with full definitions for vocabulary help and an index.
Updated for 2011, the Universe, is one book in the Britannica Illustrated Science Library Series that covers today's most popular science topics, from digital TV to microchips to touchscreens and beyond. Perennial subjects in earth science, life science, and physical science are all explored in detail. Amazing graphics-more than 1,000 per title-combined with concise summaries help students understand complex subjects. Correlated to the science curriculum in grades 5-9, each title also contains a glossary with full definitions for vocabulary.
Kuhn, Allan D.; Cotter, Gladys A.
Describes the U.S. Department of Defense (DoD) Gateway Information System, which provides communications capabilities and access to online databases for DoD microcomputer end-users. Functions, structure, development, and artificial intelligence applications of the system are discussed. (11 references) (MES)
Unwin, Jason; Peters, David
The Gateway Clinic is a specialist NHS service in South London providing acupuncture and Chinese medicine. The clinic receives a diverse range of referrals from an expanding population of local general practitioners (GPs). This study explores the referral behaviour of GPs and other primary care users of the Gateway Clinic. A pragmatic mixed-methods approach was used, combining mapping of GPs' usage of the Gateway as taken from the clinic's database between the years 2000 and 2005, a questionnaire survey of the referring primary care practitioners in 2005, and data, including a thematic analysis of the interview transcripts from semi-structured interviews of a purposive sample of those GPs who refer. Doctors in the community refer a wide range of health problems to the Gateway Clinic. The most common referrals were musculoskeletal conditions (38-44%), general and unspecified conditions (11-14%), blood and immune system conditions (6-12%), psychological conditions (8-13%), neurological conditions (6-9%), gynaecological conditions (5-6%) and digestive conditions (5-6%). The health problems referred by local healthcare practitioners correlate strongly with the patient profile seen in private acupuncture practice. Between 2000 and 2005 numbers of healthcare practitioners increased by 218% resulting in a 300% increase in patient referrals made to the clinic; the mean frequency of referral per practitioner increased by 71%. Analysis of the qualitative data suggests that positive clinical experience encourages GPs to increase the range of conditions they refer leading to the development of informal referral guidelines. The Gateway Clinic has become an increasingly popular referral resource. The influences that drive referral to the clinic are multiple and follow "tacit guidelines". GPs select patients on the basis of their individual clinical experience, informed by positive patient feedback and often only after more conventional medical treatment options have been
The paper will explore the relationship between the creation of a physical learning space and the changing conceptions of learning and teaching that are being instigated by a building, designed from the outset, with student learning in mind. The Learning Gateway has been created to support students and the development of a new curriculum as St Martin’s reshapes itself in the context of the emerging University for Cumbria. At one level, this use of the “estate” and the “ICT infrastructure” as ...
KOROL, A; The ATLAS collaboration; BOGDANCHIKOV, A; BRASOLIN, F; CONTESCU, A C; DUBROV, S; HAFEEZ, M; LEE, C J; SCANNICCHIO, D A; TWOMEY, M; VORONKOV, A; ZAYTSEV, A
The ATLAS Gateway service is implemented with a set of dedicated computer nodes to provide a fine-grained access control between CERN General Public Network (GPN) and ATLAS Technical Control Network (ATCN). ATCN connects the ATLAS online farm used for ATLAS Operations and data taking, including the ATLAS TDAQ (Trigger and Data Aquisition) and DCS (Detector Control System) nodes. In particular, it provides restricted access to the web services (proxy), general login sessions (via SSH and RDP protocols), NAT and mail relay from ATCN. At the Operating System level the implementation is based on virtualization technologies. Here we report on the Gateway upgrade during Long Shutdown 1 (LS1) period: it includes the transition to the last production release of the CERN Linux distribution (SLC6), the migration to the centralized configuration management system (based on Puppet) and the redesign of the internal system architecture.
Bijl, Peter K; Bendle, James A P; Bohaty, Steven M; Pross, Jörg; Schouten, Stefan; Tauxe, Lisa; Stickley, Catherine E; McKay, Robert M; Röhl, Ursula; Olney, Matthew; Sluijs, Appy; Escutia, Carlota; Brinkhuis, Henk
The warmest global temperatures of the past 85 million years occurred during a prolonged greenhouse episode known as the Early Eocene Climatic Optimum (52-50 Ma). The Early Eocene Climatic Optimum terminated with a long-term cooling trend that culminated in continental-scale glaciation of Antarctica from 34 Ma onward. Whereas early studies attributed the Eocene transition from greenhouse to icehouse climates to the tectonic opening of Southern Ocean gateways, more recent investigations invoked a dominant role of declining atmospheric greenhouse gas concentrations (e.g., CO2). However, the scarcity of field data has prevented empirical evaluation of these hypotheses. We present marine microfossil and organic geochemical records spanning the early-to-middle Eocene transition from the Wilkes Land Margin, East Antarctica. Dinoflagellate biogeography and sea surface temperature paleothermometry reveal that the earliest throughflow of a westbound Antarctic Counter Current began ~49-50 Ma through a southern opening of the Tasmanian Gateway. This early opening occurs in conjunction with the simultaneous onset of regional surface water and continental cooling (2-4 °C), evidenced by biomarker- and pollen-based paleothermometry. We interpret that the westbound flowing current flow across the Tasmanian Gateway resulted in cooling of Antarctic surface waters and coasts, which was conveyed to global intermediate waters through invigorated deep convection in southern high latitudes. Although atmospheric CO2 forcing alone would provide a more uniform middle Eocene cooling, the opening of the Tasmanian Gateway better explains Southern Ocean surface water and global deep ocean cooling in the apparent absence of (sub-) equatorial cooling.
Bijl, Peter K.; Bendle, James A. P.; Bohaty, Steven M.; Pross, Jörg; Schouten, Stefan; Tauxe, Lisa; Stickley, Catherine E.; McKay, Robert M.; Röhl, Ursula; Olney, Matthew; Sluijs, Appy; Escutia, Carlota; Brinkhuis, Henk; Klaus, Adam; Fehr, Annick; Williams, Trevor; Carr, Stephanie A.; Dunbar, Robert B.; Gonzàlez, Jhon J.; Hayden, Travis G.; Iwai, Masao; Jimenez-Espejo, Francisco J.; Katsuki, Kota; Kong, Gee Soo; Nakai, Mutsumi; Passchier, Sandra; Pekar, Stephen F.; Riesselman, Christina; Sakai, Toyosaburo; Shrivastava, Prakash K.; Sugisaki, Saiko; Tuo, Shouting; van de Flierdt, Tina; Welsh, Kevin; Yamane, Masako
The warmest global temperatures of the past 85 million years occurred during a prolonged greenhouse episode known as the Early Eocene Climatic Optimum (52–50 Ma). The Early Eocene Climatic Optimum terminated with a long-term cooling trend that culminated in continental-scale glaciation of Antarctica from 34 Ma onward. Whereas early studies attributed the Eocene transition from greenhouse to icehouse climates to the tectonic opening of Southern Ocean gateways, more recent investigations invoked a dominant role of declining atmospheric greenhouse gas concentrations (e.g., CO2). However, the scarcity of field data has prevented empirical evaluation of these hypotheses. We present marine microfossil and organic geochemical records spanning the early-to-middle Eocene transition from the Wilkes Land Margin, East Antarctica. Dinoflagellate biogeography and sea surface temperature paleothermometry reveal that the earliest throughflow of a westbound Antarctic Counter Current began ∼49–50 Ma through a southern opening of the Tasmanian Gateway. This early opening occurs in conjunction with the simultaneous onset of regional surface water and continental cooling (2–4 °C), evidenced by biomarker- and pollen-based paleothermometry. We interpret that the westbound flowing current flow across the Tasmanian Gateway resulted in cooling of Antarctic surface waters and coasts, which was conveyed to global intermediate waters through invigorated deep convection in southern high latitudes. Although atmospheric CO2 forcing alone would provide a more uniform middle Eocene cooling, the opening of the Tasmanian Gateway better explains Southern Ocean surface water and global deep ocean cooling in the apparent absence of (sub-) equatorial cooling. PMID:23720311
Minki Cha; Jung-Hyok Kwon; SungJin Kim; Taeshik Shon; Eui-Jik Kim
In this paper, a data aggregation gateway framework (DA-GW) for constrained application protocol (CoAP) group communications is proposed. The DA-GW framework is designed to improve the throughput performance and energy efficiency of group communication to monitor and control multiple sensor devices collectively with a single user terminal. The DA-GW consists of four function blocks—the message analyzer, group manager, message scheduler and data handler—and three informative databases—the clie...
Huang, Y.; Sun, H. [China University of Mining and Technology (China). Beijing Graduate School
Based on analysis of roof collapsing characteristics in gateways maintained along the goaf, the concept and method for designing gateway side packing parameters is described. Examples of maintaining along the goaf a gateway by packing with quick-setting materials with high water content are given. It is proved that the technical and economic benefits of this method are remarkable. The method is of important significance to the practice. 2 refs., 2 figs., 2 tabs.
Romeo, G.; Barnes, R. J.; Ukhorskiy, A. Y.; Sotirelis, T.; Stephens, G. K.; Kessel, R.; Potter, M.
The Van Allen Probes Science Gateway acts a centralized interface to the instrument Science Operation Centers (SOCs), provides mission planning tools, and hosts a number of science related activities such as the mission bibliography. Most importantly, the Gateway acts as the primary site for processing and delivering the Van Allen Probes Space Weather data to users. Over the past years, the web-site has been completely redesigned with the focus on easier navigation and improvements of the existing tools such as the orbit plotter, position calculator and magnetic footprint tool. In addition, a new data plotting facility has been added. Based on HTML5, which allows users to interactively plot Van Allen Probes science and space weather data. The user can tailor the tool to display exactly the plot they wish to see and then share this with other users via either a URL or by QR code. Various types of plots can be created, including, simple time series, data plotted as a function of orbital location, and time versus L-Shell, capability of visualizing data from both probes (A & B) on the same plot. In cooperation with all Van Allen Probes Instrument SOCs, the Science Gateway will soon be able to serve higher level data products (Level 3), and to visualize them via the above mentioned HTML5 interface. Users will also be able to create customized CDF files on the fly.
Hens, Raf; Goeminne, Nico; Van Hoecke, Sofie; Verdickt, Tom; Bouve, Thomas; Gielen, Frank; Demeester, Piet
Although mobile users are currently offered a lot more capabilities on their mobile devices, they still experience some limitations. They can surf the Internet, read their e-mail and receive MMS messages, but they have limited processing power, storage capacity and bandwidth and are limited in their access to peripherals (e.g. printers). We have designed and implemented a multimedia gateway for mobile devices that reduces these limitations. It gives the mobile devices transparent access to high capacity devices connected to the gateway, which is built around a central, modularly extensible server that can run on any PC or home gateway. It manages two sets of modules: one set offering the actual services and another set handling the IP-based wireless interaction with the client applications on the mobile devices. These modules can be added and removed dynamically, offering new services on the fly. Currently services for storage, printing, domotics and playing music are provided. Others can easily be added later on. This paper discusses the architecture and development, the management of modules, the actual services and their benefits. Besides a proprietary implementation, it also looks into OSGi and how both platforms compare to each other, concerning design, architecture, ease of development, functionality, ...
Shearin, Harold K; Dvarishkis, Alisa R; Kozeluh, Craig D; Stowers, R Steven
Precise manipulation of transgene expression in genetic model organisms has led to advances in understanding fundamental mechanisms of development, physiology, and genetic disease. Transgene construction is, however, a precondition of transgene expression, and often limits the rate of experimental progress. Here we report an expansion of the modular Gateway MultiSite recombination-cloning platform for high efficiency transgene assembly. The expansion includes two additional destination vectors and entry clones for the LexA binary transcription system, among others. These new tools enhance the expression levels possible with Gateway MultiSite generated transgenes and make possible the generation of LexA drivers and reporters with Gateway MultiSite cloning. In vivo data from transgenic Drosophila functionally validating each novel component are presented and include neuronal LexA drivers, LexAop2 red and green fluorescent synaptic vesicle reporters, TDC2 and TRH LexA, GAL4, and QF drivers, and LexAop2, UAS, and QUAS channelrhodopsin2 T159C reporters.
Keller, G.; Zenker, C.E.; Stone, S.M.
Planktic foraminiferal provinces of Caribbean DSDP Hole 502A and East Pacific DSDP Hole 503A have been analyzed and compared with benthic and planktic isotope records, carbonate, hiatus events, and sea level changes. Four major events are evident in the closure history of the Pacific-Caribbean gateway, at 6.2, 4.2, 2.4 and 1.8 Ma. The faunal change at 6.2 Ma coincides with the ??13C shift and is primarily caused by upwelling in the western Caribbean. This suggests restricted circulation of intermediate water and deflection northeastward, strengthening the Gulf Stream as reflected in the first major erosion on Blake Plateau. The second faunal change, at 4.2 Ma, coincides with increased surface water salinity evident in ??18O data and indicates increasingly restricted surface water exchange. Divergence of faunal provinces beginning at 2.4 Ma is marked by increasing abundance of high salinity tolerant species (Globigerinoides ruber) in the Caribbean. This suggests that initial closure of the Pacific-Caribbean gateway and cessation of sustained surface current flow between the Pacific and Caribbean occurred as late as 2.4 Ma. Maximum divergence of faunal provinces begins at 1.8 Ma and continues to the present. This implies that at least incipient littoral-neritic leakage occurred across the Pacific-Caribbean gateway between 2.4 and 1.8 Ma, with final closure by 1.8 Ma. ?? 1989.
Sivagnanam, Subhashini; Majumdar, Amit; Yoshimoto, Kenneth; Astakhov, Vadim; Bandrowski, Anita; Martone, MaryAnn; Carnevale, Nicholas T
The last few decades have seen the emergence of computational neuroscience as a mature field where researchers are interested in modeling complex and large neuronal systems and require access to high performance computing machines and associated cyber infrastructure to manage computational workflow and data. The neuronal simulation tools, used in this research field, are also implemented for parallel computers and suitable for high performance computing machines. But using these tools on complex high performance computing machines remains a challenge because of issues with acquiring computer time on these machines located at national supercomputer centers, dealing with complex user interface of these machines, dealing with data management and retrieval. The Neuroscience Gateway is being developed to alleviate and/or hide these barriers to entry for computational neuroscientists. It hides or eliminates, from the point of view of the users, all the administrative and technical barriers and makes parallel neuronal simulation tools easily available and accessible on complex high performance computing machines. It handles the running of jobs and data management and retrieval. This paper shares the early experiences in bringing up this gateway and describes the software architecture it is based on, how it is implemented, and how users can use this for computational neuroscience research using high performance computing at the back end. We also look at parallel scaling of some publicly available neuronal models and analyze the recent usage data of the neuroscience gateway.
Full Text Available In wireless sensor networks (WSNs, efficient energy conservation is required to prolong the lifetime of the network. In this work, we have given emphasis on balanced energy consumption and energy holes avoidance. This paper proposes a multi-gateway-based approach to reduce the transmission distance between the sender and the sink node. The area to be monitored is divided into regions and gateway nodes are deployed at optimal positions. We have designed a transmission scheme, in which sensors in the sink region communicate directly to the sink, sensors in the gateway region communicate directly to the gateway, and sensors in the cluster region transmit their data directly to their respective cluster head which transmits data to the gateway in its region. If the distance between a cluster head and the sink is less than the distance between the cluster head and the gateway node, the cluster head transmits data to the sink instead of the gateway node. We have compared the proposed protocol with Low-Energy Adaptive Clustering Hierarchy (LEACH, Gateway Based Energy Aware Multi-Hop Routing (M-GEAR, and Gateway Based Stable Election Protocol (GSEP protocols. The protocol performs better than other protocols in terms of throughput, stability period, lifetime, residual energy, and the packet transmitted to the sink.
Alexander, Charles; Chen, Eric; Grumbach, Kevin
To determine whether underrepresented minority (URM) students receive lower grades than do non-URM students in college prehealth gateway courses; the extent to which lower grade performance might be explained by the differences in precollege academic achievement; and whether URM students are less likely than non-URM students to persist in completing at least four gateway courses. Administrative data were obtained from six California colleges on 15,000 college students who matriculated in the 1999-2000 or 2000-2001 academic years and enrolled in at least one college course required for application to medical or dental school ("gateway" courses). Students were compared across ethnic groups in gateway course grade performance and persistence in completing at least four gateway courses, using regression methods to control for students' college admission test scores and caliber of high school attended. URM students received significantly lower grades on average in gateway courses than did white students. This gap persisted after adjusting for measures of prior academic performance. However, URM students were nearly as likely as white students to persist in completing at least four gateway courses. After accounting for the lower grades of URM students in their initial classes, URM students were more likely than white students to complete four or more gateway courses. URM students experienced academic challenges, but many persist in their prehealth courses despite these challenges. Interventions at the college level to support URM student performance in gateway courses are particularly important for increasing the diversity of medical and dental schools.
Paulson, Steve; Barrett, Deirdre; Bulkeley, Kelly; Naiman, Rubin
Where do our dreams originate from, and what do they tell us? Is there a universal set of symbols that are common to all dreams, regardless of a person's ethnicity or culture? What does dreaming reveal about the unconscious? Why do some dreams remain etched in our memories, whereas others are almost instantly forgotten? Some scientists have adopted the position that dreams are little more than noise in the brain, without any substantive purpose or function. Yet, such a stance seemingly runs counter to the experience of many people who reflect upon and even analyze their dreams, often in search of clues to their daily lives or insights into their deeper selves. Similarly, in virtually all wisdom traditions, dreams are invoked as an important source of revelation or prophecy. Steve Paulson, executive producer and host of To the Best of Our Knowledge, moderated a discussion that included psychologist Deirdre Barrett, dream researcher Kelly Bulkeley, and psychologist and sleep/dream medicine specialist Rubin Naiman; they examined dreams from a variety of perspectives to answer these questions. © 2017 New York Academy of Sciences.
Yeast two-hybrid system combined with the gateway technology will greatly facilitate the cloning of interested DNA fragment into yeast two-hybrid vectors and therefore increase the efficiency of yeast two-hybrid analysis. In this study, we constructed a pair of Gateway-compatible yeast two-hybrid vectors pBTM116GW and ...
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP10-448-000] Appalachian Gateway Project; Notice of Availability of Draft General Conformity Analysis In accordance with the... (GCD) for the Appalachian Gateway Project (Project) to assess the potential air quality impacts...
Gillies, Alison R; Hsii, Judy F; Oak, Seachol; Wood, David W
We have combined Invitrogen's Gateway cloning technology with self-cleaving purification tags to generate a new system for rapid production of recombinant protein products. To accomplish this, we engineered our previously reported DeltaI-CM cleaving intein to include a Gateway cloning recognition sequence, and demonstrated that the resulting Gateway-competent intein is unaffected. This intein can therefore be used in several previously reported purification methods, while at the same time being compatible with Gateway cloning. We have incorporated this intein into a set of Gateway vectors, which include self-cleaving elastin-like polypeptide (ELP), chitin binding domain (CBD), phasin (polyhydroxybutyrate-binding), or maltose binding domain (MBD) tags. These vectors were verified by Gateway cloning of TEM-1 beta-lactamase and Escherichia coli catalase genes, and the expressed target proteins were purified using the four methods encoded on the vectors. The purification methods were unaffected by replacing the DeltaI-CM intein with the Gateway intein. It was observed that some purification methods were more appropriate for each target than others, suggesting utility of this technology for rapid process identification and optimization. The modular design of the Gateway system and intein purification method suggests that any tag and promoter can be trivially added to this system for the development of additional expression vectors. This technology could greatly facilitate process optimization, allowing several targets and methods to be tested in a high-throughput manner.
"Data Notes" is a bimonthly publication that examines data to illuminate the challenges facing Achieving the Dream colleges and to chart their progress over time. Gateway courses generally include the first college-level English and math courses students are required to take. Increasing the number of students who attempt gateway classes…
Willard, Jacklyn Altuna; Bayes, Brian; Martinez, John
This study reports on the implementation of Gateway to College, a program whose mission is to serve students who have dropped out of high school, or who are at risk of dropping out of high school, by allowing them to earn a high school diploma and credits toward a postsecondary degree. Gateway to College is uniquely ambitious in providing…
Albrecht, Bryan D.
The purpose of this study was to determine what opinions Gateway Technical College instructors had toward secondary and postsecondary program alignment. Student transition is critical to supporting the mission and vision of Gateway Technical College. The impetus for this study was twofold. First, the quality improvement process established at…
A series of studies evaluated the Gateway configuration of R1-6 in-street signs. A : Gateway configuration consists of an R1-6 sign on the centerline, an R1-6 signs on both edges of : the roadway, and R1-6 signs on the lane lines if it is a multilane...
A series of studies evaluated the Gateway configuration of R1-6 in-street signs. A Gateway configuration consists of an R1-6 sign on the centerline, an R1-6 signs on both edges of the roadway, and R1-6 signs on the lane lines if it is a multilane roa...
...: http://www.blm.gov/wy/st/en/info/NEPA/documents/hdd/gateway_south.html . In order to be considered in...: http://www.blm.gov/wy/st/en/info/NEPA/documents/hdd/gateway_south.html . E-mail: GatewaySouth_WYMail... Mexico), and notice of its availability was published on November 28, 2008 (73 FR 72521). Records of...
... 4500060036] Gateway West Project Subcommittee of the Resource Advisory Council to the Boise District; Public...) Gateway West Project Subcommittee of the Boise District Resource Advisory Council (RAC), will hold..., ID 83705, Telephone (208) 384-3364. SUPPLEMENTARY INFORMATION: The Gateway West Project Subcommittee...
... DEPARTMENT OF THE INTERIOR [NPS-NERO-GATE-0112-9494; 1770-OZC] Establishment of the Gateway... announcing the establishment of the Gateway National Recreation Area Fort Hancock 21st Century Advisory... Fort Hancock Historic Landmark District of Gateway National Recreation area. The Department of the...
... Restriction at Phoenix-Mesa Gateway Airport, Mesa, AZ AGENCY: Federal Aviation Administration, DOT. ACTION... restriction covering 52.6 acres of property abutting Phoenix-Mesa Gateway, Mesa, Arizona, from all conditions... to Mr. Walter Fix, Phoenix-Gateway Airport Authority, 5835 S. Sossaman Road, Mesa, Arizona 85212...
... Receivership of 10146, Gateway Bank of St. Louis, St. Louis, MO Notice is hereby given that the Federal Deposit Insurance Corporation (``FDIC'') as Receiver for Gateway Bank of St. Louis, (``the Receiver'') intends to terminate its receivership for said institution. The FDIC was appointed receiver of Gateway Bank of St...
Jeanne-Nicole Mellon Saint-Laurent
Full Text Available This article describes The Gateway to the Syriac Saints, a database project developed by the Syriac Reference Portal (www.syriaca.org. It is a research tool for the study of Syriac saints and hagiographic texts. The Gateway to the Syriac Saints is a two-volume database: 1 Qadishe and 2 Bibliotheca Hagiographica Syriaca Electronica (BHSE. Hagiography, the lives of the saints, is a multiform genre. It contains elements of myth, history, biblical exegesis, romance, and theology. The production of saints’ lives blossomed in late antiquity alongside the growth of the cult of the saints. Scholars have attended to hagiographic traditions in Greek and Latin, but many scholars have yet to discover the richness of Syriac hagiographic literature: the stories, homilies, and hymns on the saints that Christians of the Middle East told and preserved. It is our hope that our database will give scholars and students increased access to these traditions to generate new scholarship. The first volume, Qadishe or “saints” in Syriac, is a digital catalogue of saints or holy persons venerated in the Syriac tradition. Some saints are native to the Syriac-speaking milieu, whereas others come from other linguistic or cultural traditions. Through the translation of their hagiographies and the diffusion of saints’ cults in the late antique world, saints were adopted, “imported,” and appropriated into Syriac religious memory. The second volume, the BHSE, focuses on Syriac hagiographic texts. The BHSE contains the titles of over 1000 Syriac stories, hymns, and homilies on saints. It also includes authors’ or hagiographers’ names, the first and last lines of the texts (in Syriac, English, and French, bibliographic information, and the names of the manuscripts containing these hagiographic works. We have also listed modern and ancient translations of these works. All of the data in the Gateway to the Syriac Saints has been encoded in TEI, and it is fully
Full Text Available The gateway reflex is a new phenomenon that explains how immune cells bypass the blood–brain barrier to infiltrate the central nervous system (CNS and trigger neuroinflammation. To date, four examples of gateway reflexes have been discovered, each described by the stimulus that evokes the reflex. Gravity, electricity, pain, and stress have all been found to create gateways at specific regions of the CNS. The gateway reflex, the most recently discovered of the four, has also been shown to upset the homeostasis of organs in the periphery through its action on the CNS. These reflexes provide novel therapeutic targets for the control of local neuroinflammation and organ function. Each gateway reflex is activated by different neural activations and induces inflmammation at different regions in the CNS. Therefore, it is theoretically possible to manipulate each independently, providing a novel therapeutic strategy to control local neuroinflammation and peripheral organ homeostasis.
Tanaka, Yuki; Arima, Yasunobu; Kamimura, Daisuke; Murakami, Masaaki
The gateway reflex is a new phenomenon that explains how immune cells bypass the blood-brain barrier to infiltrate the central nervous system (CNS) and trigger neuroinflammation. To date, four examples of gateway reflexes have been discovered, each described by the stimulus that evokes the reflex. Gravity, electricity, pain, and stress have all been found to create gateways at specific regions of the CNS. The gateway reflex, the most recently discovered of the four, has also been shown to upset the homeostasis of organs in the periphery through its action on the CNS. These reflexes provide novel therapeutic targets for the control of local neuroinflammation and organ function. Each gateway reflex is activated by different neural activations and induces inflmammation at different regions in the CNS. Therefore, it is theoretically possible to manipulate each independently, providing a novel therapeutic strategy to control local neuroinflammation and peripheral organ homeostasis.
Park, KeeHyun; Pak, JuGeon
We propose an integrated gateway for various personal health devices (PHDs). This gateway receives measurements from various PHDs and conveys them to a remote monitoring server (MS). It provides two kinds of transmission modes: immediate transmission and integrated transmission. The former mode operates if a measurement exceeds a predetermined threshold or in the case of an emergency. In the latter mode, the gateway retains the measurements instead of forwarding them. When the reporting time comes, the gateway extracts all the stored measurements, integrates them into one message, and transmits the integrated message to the MS. Through this mechanism, the transmission overhead can be reduced. On the basis of the proposed gateway, we construct a u-healthcare system comprising an activity monitor, a medication dispenser, and a pulse oximeter. The evaluation results show that the size of separate messages from various PHDs is reduced through the integration process, and the process does not require much time; the integration time is negligible.
Maldonado-Molina, Mildred M; Lanza, Stephanie T
A progressive and hierarchical sequence of drug use suggests that a sequence of stages of drug use can describe the order by which adolescents try drugs. We propose an operational definition to test gateway relations by providing a framework with the aim of describing a set of conditions to guide the evaluation of whether a drug serves as a gateway for another drug. We used data from the National Longitudinal Study of Adolescent Health to demonstrate how using latent transition analysis we can estimate the odds of using a drug at a later time conditional on having used a gateway drug at an earlier time. We provide three empirical demonstrations for testing the gateway relations using a national and longitudinal data of adolescents (e.g., gateway relation between cigarettes and marijuana, alcohol and marijuana, and alcohol and cigarettes).
Dufty, James W.
This is the Final Technical Report for DE-FG02-2ER54677 award 'Time Dependent Hartree Fock Equation - Gateway to Nonequilibrium Plasmas'. Research has focused on the nonequilibrium dynamics of electrons in the presence of ions, both via basic quantum theory and via semi-classical molecular dynamics (MD) simulation. In addition, fundamental notions of dissipative dynamics have been explored for models of grains and dust, and for scalar fields (temperature) in turbulent edge plasmas. The specific topics addressed were Quantum Kinetic Theory for Metallic Clusters, Semi-classical MD Simulation of Plasmas , and Effects of Dissipative Dynamics.
Saja aasta möödumise puhul Esimesest maailmasõjast kutsus Euroopa Komisjon ellu European Film Gateway projekti EFG 1914. Avalikkusele on nüüd kättesaadav 660 tundi digiteeritud filme ja 5500 plakatit, fotot ja dokumenti. Nendega saab tutvuda aadressidel http://project.efg1914.eu ja http://www.europeanfilmgateway.eu/content/efg1914-project. Rahvusarhiivist on portaali lisatud kaks tundi Johannes Pääsukese ülesvõetud etnograafilist materjali, Pathé ringvaade nr. 17 (sõjategevus 1917) ja Theodor Lutsu film "Noored kotkad" (1927) ning Karl Akeli ja Johann Ostrati fotosid
Hu, Zhonggong; Feng, Xiancheng
Based on digitization, multimedia, mobility, wide band, real-time interaction and so on,family networks, because can provide diverse and personalized synthesis service in information, correspondence work, entertainment, education and health care and so on, are more and more paid attention by the market. The family network product development has become the focus of the related industry. In this paper,the concept of the family network and the overall reference model of the family network are introduced firstly.Then the core techniques and the correspondence standard related with the family network are proposed.The key analysis is made for the function of family gateway, the function module of the software,the key technologies to client side software architecture and the trend of development of the family network entertainment seeing and hearing service and so on. Product present situation of the family gateway and the future trend of development, application solution of the digital family service are introduced. The development of the family network product bringing about the digital family network industry is introduced finally.It causes the development of software industries,such as communication industry,electrical appliances industry, computer and game and so on.It also causes the development of estate industry.
With the increasing demand for home lifestyle, the traditional smart home products have been unable to meet the needs of users. Aim at the complex wiring, high cost and difficult operation problems of traditional smart home system, this paper designs a home gateway for smart home system based on Wi-Fi and ZigBee. This paper first gives a smart home system architecture base on cloud server, Wi-Fi and ZigBee. This architecture enables users to access the smart home system remotely from Internet through the cloud server or through Wi-Fi at home. It also offers the flexibility and low cost of ZigBee wireless networking for home equipment. This paper analyzes the functional requirements of the home gateway, and designs a modular hardware architecture based on the RT5350 wireless gateway module and the CC2530 ZigBee coordinator module. Also designs the software of the home gateway, including the gateway master program and the ZigBee coordinator program. Finally, the smart home system and home gateway are tested in two kinds of network environments, internal network and external network. The test results show that the designed home gateway can meet the requirements, support remote and local access, support multi-user, support information security technology, and can timely report equipment status information.
Ogura, Hideki; Arima, Yasunobu; Kamimura, Daisuke; Murakami, Masaaki
The inflammation amplifier, a nuclear factor-kappa B (NF-kB)feedback loop in non-immune cells including fibroblasts and endothelial cells, describes how NF-kB-mediated transcriptions are enhanced to induce the inflammation in the presence of signal Tranducer and Activator of Transcription 3 (STAT3) activation. It was originally discovered in rheumatoid arthritis and multiple sclerosis mouse models and has since been shown to be associated with various human diseases and disorders including autoimmune diseases, metabolic syndromes, neurodegenerative diseases, and other inflammatory diseases. The amplifier begins with IL-17, which acts as the main signal to express NF-kB-mediated transcriptions, and IL-6, an NF-kB target, which functions as a fuel for the inflammation amplifier. Indeed, other NF-kB targets including various chemokines also act as effector molecules that cause local accumulation of various immune cells and subsequent inflammation. Through extensive studies in the multiple sclerosis model experimental autoimmune encephalomyelitis, we recently demonstrated that regional neural activation induces excess activation of the inflammation amplifier at specific blood vessels in the fifth lumbar cord, creating a gateway for immune cells to enter the central nervous system (CNS). We thus propose the gateway theory to describe how regional neural activation enables immune cells to enter the CNS from the blood and argue that this theory might provide novel therapeutic targets for inflammatory diseases and disorders.
Zhu, Guo-sheng; Yu, Shao-hua; Dai, Jin-you
This paper proposed a scalable architecture of IPv4-IPv6 internetworking gateway based on EZchip 10Gbps network processor NP-1c. The Application Layer Gateway(ALG) of control plane can be upgraded without needing to modify the data forwarding plane.A SIP ALG of 3GPP IMS(IP Multimedia Subsystem)was implemented and tested under real China Next Generation Internet(CNGI) network environment.IPv4 SIP UEs can communicate with IPv6 SIP UEs through the gateway.
Christiansen, David Raymond; Carbone, Marco; Hildebrandt, Thomas
We present the first direct formalization of the semantics of inclusive gateways as described in the Business Process Modeling Notation (BPMN) 2.0 Beta 1 specification. The formal semantics is given for a minimal subset of BPMN 2.0 containing just the inclusive and exclusive gateways and the start and stop events. By focusing on this subset we achieve a simple graph model that highlights the particular non-local features of the inclusive gateway semantics. We sketch two ways of implementing the semantics using algorithms based on incrementally updated data structures and also discuss distributed communication-based implementations of the two algorithms.
Glasscoe, M. T.; Stough, T. M.; Parker, J. W.; Burl, M. C.; Donnellan, A.; Blom, R. G.; Pierce, M. E.; Wang, J.; Ma, Y.; Rundle, J. B.; Yoder, M. R.
Earthquake Data Enhanced Cyber-Infrastructure for Disaster Evaluation and Response (E-DECIDER) is a NASA-funded project developing capabilities for decision-making utilizing remote sensing data and modeling software in order to provide decision support for earthquake disaster management and response. E-DECIDER incorporates earthquake forecasting methodology and geophysical modeling tools developed through NASA's QuakeSim project in order to produce standards-compliant map data products to aid in decision-making following an earthquake. Remote sensing and geodetic data, in conjunction with modeling and forecasting tools, help provide both long-term planning information for disaster management decision makers as well as short-term information following earthquake events (i.e. identifying areas where the greatest deformation and damage has occurred and emergency services may need to be focused). E-DECIDER utilizes a service-based GIS model for its cyber-infrastructure in order to produce standards-compliant products for different user types with multiple service protocols (such as KML, WMS, WFS, and WCS). The goal is to make complex GIS processing and domain-specific analysis tools more accessible to general users through software services as well as provide system sustainability through infrastructure services. The system comprises several components, which include: a GeoServer for thematic mapping and data distribution, a geospatial database for storage and spatial analysis, web service APIs, including simple-to-use REST APIs for complex GIS functionalities, and geoprocessing tools including python scripts to produce standards-compliant data products. These are then served to the E-DECIDER decision support gateway (http://e-decider.org), the E-DECIDER mobile interface, and to the Department of Homeland Security decision support middleware UICDS (Unified Incident Command and Decision Support). The E-DECIDER decision support gateway features a web interface that
Gaonkar, C A; Sawant, S S; Anil, A C; Venkat, K; Harkantra, S N
Ships have been identified as one of the important vectors in the translocation of organisms from one bioregion to another leading to bioinvasion. In this context, harbours serve as a gateway for the introduction of alien species. Surveys were carried out in the vicinity of ports of Mumbai for macrobenthic fauna, zooplankton and hard substratum community on three different occasions during 2001-2002. The study shows that 14 polychaete species are recently introduced to this area. Mytilopsis sallei, a bivalve, which is an invasive species in the Indian context continued to be present but was restricted to enclosed docks, indicating preference for embayed water bodies. The polychaete Protula tubularia was abundant in the hard substratum community and is being reported as a possible ship-mediated introduction.
Full Text Available In the development of new technologies based on mobile system, there is a growing interest as a fundamental technology. In particular, in order to realize a mobile office and mobile phones, conferencing remote document is a technique that can realize smart network services solutions with enhanced real-time communication, real-time information sharing, and collaboration. Therefore, in this paper, the design meets the diverse needs of customers and the smart work platform mobile-based fast and conveniently it is trying to develop. For this reason, I have developed a mobile gateway that is based on the communication server construction OPEN API development, management of mobile ID, protocol design, and design of SSL/TLS security tunnel. Also, we developed a smart work platform that you apply this, you are trying to provide information systems environment of mobile company.
Toni Tegar Sahidi
Full Text Available Internet of things (IoT is a complex system with few best practices in building ones, especially on handling real-time communication between IoT devices to the Internet. A framework is often used to fasten building IoT system. This paper present Mobile Internet of Things (MIOT, a framework which use a smartphone as the main component to handle communication between IoT device and the internet. A smartphone is used as the communication gateway (relay for IoT devices and not as the IoT controller as in common Smartphone-IoT approach. For evaluation purpose, two implementations of IoT prototype scenario is built, an environmental monitoring and a remote controller (RC car. The experiment shows a quick and easy deployment of IoT system. The Environment Monitoring able to send data to the server in real-time, and control The RC Car with a reasonable response time.The experiment on 200 ms interval between each packet, shows that MIOT Framework has round-trip latency between MIOT Server and IoT hardware for ≈ 88.007 ms. The addition of smartphone as the main component in the framework (MIOT Apps contribute to additional latency ≈ 13.145 ms. Using a Smartphone as a gateway for IoT in MIOT Framework is possible and promising. It can be used as a best practice to develop a reliable IoT system which reduces time, effort, and learning overhead on building IoT systems.
Vuorinen, V.; Keskinen, K.
Computational fluid dynamics (CFD) research is increasingly much focused towards computationally intensive, eddy resolving simulation techniques of turbulent flows such as large-eddy simulation (LES) and direct numerical simulation (DNS). Here, we present a compact educational software package called DNSLab, tailored for learning partial differential equations of turbulence from the perspective of DNS in Matlab environment. Based on educational experiences and course feedback from tens of engineering post-graduate students and industrial engineers, DNSLab can offer a major gateway to turbulence simulation with minimal prerequisites. Matlab implementation of two common fractional step projection methods is considered: the 2d Fourier pseudo-spectral method, and the 3d finite difference method with 2nd order spatial accuracy. Both methods are based on vectorization in Matlab and the slow for-loops are thus avoided. DNSLab is tested on two basic problems which we have noted to be of high educational value: 2d periodic array of decaying vortices, and 3d turbulent channel flow at Reτ = 180. To the best of our knowledge, the present study is possibly the first to investigate efficiency of a 3d turbulent, wall bounded flow in Matlab. The accuracy and efficiency of DNSLab is compared with a customized OpenFOAM solver called rk4projectionFoam. Based on our experiences and course feedback, the main contribution of DNSLab consists of the following features. (i) The very compact Matlab implementation of present Navier-Stokes solvers provides a gateway to efficient learning of both, physics of turbulent flows, and simulation of turbulence. (ii) Only relatively minor prerequisites on fluid dynamics and numerical methods are required for using DNSLab. (iii) In 2d, interactive results for turbulent flow cases can be obtained. Even for a 3d channel flow, the solver is fast enough for nearly interactive educational use. (iv) DNSLab is made openly available and thus contributing to
Jaffer, Ghulam; Nader, Ronnie; Koudelka, Otto
Students in higher education, and scientific and technological researchers want to communicate with the International Space Station (ISS), download live satellite images, and receive telemetry, housekeeping and science/engineering data from nano-satellites and larger spacecrafts. To meet this need the Ecuadorian Civilian Space Agency (EXA) has recently provided the civilian world with an internet-to-orbit gateway (Hermes-A/Minotaur) Space Flight Control Center (SFCC) available for public use. The gateway has a maximum range of tracking and detection of 22,000 km and sensitivity such that it can receive and discriminate the signals from a satellite transmitter with power˜0.1 W. The capability is enough to receive the faintest low-earth-orbit (LEO) satellites. This gateway virtually connects participating internet clients around the world to a remote satellite ground station (GS), providing a broad community for multinational cooperation. The goal of the GS is to lower financial and engineering barriers that hinder access to science and engineering data from orbit. The basic design of the virtual GS on a user side is based on free software suites. Using these and other software tools the GS is able to provide access to orbit for a multitude of users without each having to go through the costly setups. We present the design and implementation of the virtual GS in a higher education and scientific outreach settings. We also discuss the basic architecture of the single existing system and the benefits of a proposed distributed system. Details of the software tools and their applicability to synchronous round-the-world tracking, monitoring and processing performed by students and teams at Graz University of Technology, Austria, EXA-Ecuador, University of Michigan, USA and JAXA who have participated in various mission operations and have investigated real-time satellite data download and image acquisition and processing. Students and other remote users at these
Cohen, B. A.; Eigenbrode, J. A.; Young, K. E.; Bleacher, J. E.; Trainer, M. E.
The Deep Space Gateway could uniquely enable a lunar robotic sampling campaign that would provide incredible science return as well as feed forward to Mars and Europa by testing instrument sterility and ability to distinguish biogenic signals.
NSGIC State | GIS Inventory — Over the past five years, the East-West Gateway Council of Governments has facilitated creation of data layers to enhance conservation and transportation planning in...
Siegler, M.; Ruf, C.; Putzig, N.; Morgan, G.; Hayne, P.; Paige, D.; Nagihara, S.; Weber, R.
We would like to present a concept to use the Deep Space Gateway as a platform for constraining the geothermal heat production, surface, and near-surface rocks, and dielectric properties of the Moon from orbit with passive microwave radiometery.
The National Park Service Gateway National Recreation Area (GATE) was created to provide convenient access to outdoor recreation in the National Park System for residents and visitors to the New York City (NYC) area. The Volpe Center completed a numb...
Estornell, Leandro H; Granell, Antonio; Orzaez, Diego
MultiSite Gateway cloning techniques based on homologous recombination facilitate the combinatorial assembly of basic genetic pieces (i.e., promoters, CDS, and terminators) into gene expression or gene silencing cassettes. pENFRUIT is a collection of MultiSite Triple Gateway Entry vectors dedicated to genetic engineering in fruits. It comprises a number of fruit-operating promoters as well as C-terminal tags adapted to the Gateway standard. In this way, flanking regulatory/labeling sequences can be easily Gateway-assembled with a given gene of interest for its ectopic expression or silencing in fruits. The resulting gene constructs can be analyzed in stable transgenic plants or in transient expression assays, the latter allowing fast testing of the increasing number of combinations arising from MultiSite methodology. A detailed description of the use of MultiSite cloning methodology for the assembly of pENFRUIT elements is presented.
The Gateway Monument Demonstration Program (GMDP) facilitated the construction of freestanding structures or signage along roadways to communicate the name of a city, county or township to motorists. The GMDP spanned a four-year period, commencing on...
This Demonstration Team Final Report has been prepared to provide an overview of the conduct and qualitative : findings of the LA-Gateway FRATIS development and testing program. More specifically, this document provides: : A description of the te...
McCutcheon, James C; Watts, Stephen J
Gateway theory has been the source of much debate in both the research literature and public policy. Support for gateway sequencing has been mixed, especially in research that has considered the role of criminological variables in the etiology of substance use. For example, limited prior research has observed as important in gateway sequencing the effects of severe stressors. Data from the National Longitudinal Study of Adolescent to Adult Health are utilized to test gateway theory and examine whether severe stressors affect the relationship between frequency of cannabis use and later use of other illicit drugs (OIDs). Findings suggest that while frequency of cannabis use does increase the likelihood of later use of OIDs, this relationship may be the result of the common cause of experiencing severe stress. Implications of the findings are discussed.
Cichan, T.; Hopkins, J. B.; Bierhaus, B.; Murrow, D. W.
The Deep Space Gateway can enable or enhance exploration of the lunar surface through two capabilities: 1. communications relay, opening up access to the lunar farside, and 2. sample return, enhancing the ability to return large sample masses.
Berinstain, A.; Richards, R. D.
The authors will present options for discussion among participants of how low-cost lunar and planetary missions using the Moon Express family of spacecraft can be enabled by the presence of the Deep Space Gateway.
Foster, B. D.; Matthews, B.
Investigation on the Deep Space Gateway will involve experiments/operations inside pressurized modules. Support for those experiments may necessitate a means to fabricate and repair required articles. This capability can be provided through an additive manufacturing (AM) system.
Kimura, Tetsuya; Nakao, Akihide; Murata, Sachiko; Kobayashi, Yasuyuki; Tanaka, Yuji; Shibahara, Kenta; Kawazu, Tetsu; Nakagawa, Tsuyoshi
We developed the Gateway recycling cloning system, which allows multiple linking of expression cassettes by multiple rounds of the Gateway LR reaction. Employing this system, the recycling donor vector pRED419 was subjected to the first LR reaction with an attR1-attR2 type destination vector. Then conversion vector pCON was subjected to an LR reaction to restore the attR1-attR2 site on the destination vector for the next cloning cycle. By repetition of these two simple steps, we linked four expression cassettes of a reporter gene in Gateway binary vector pGWB1, introduced the constructs into tobacco BY-2 cells, and observed the expression of transgenes.
Keith, B.; Ferry, D.; Fendler, E.
Communications gateway software, GATEWAY, provides process-to-process communication between remote applications programs in different protocol domains. Communicating peer processes may be resident on any paired combination of NETEX, DECnet, or TCP/IP hosts. Provides necessary mapping from one protocol to another and facilitates practical intermachine communications in cost-effective manner by eliminating need to standardize on single protocol or to implement multiple protocols in host computers. Written in Ada.
Summary of a GATEWAY report evaluation at the offices of Aurora Lighting Design, Inc., in Grayslake, IL, where the GATEWAY program conducted its first investigation involving OLED lighting. The project experienced several challenges, but also highlighted a number of promising attributes – which indicate that with continued improvements in efficacy, longevity, size, and flexibility, OLEDs could provide a new tool for creative and effective lighting.
Simalango, Mikael Fernandus; Kim, Youngchul; Seo, Young Tae; Choi, Young Hwan; Cho, Yong Kyun
The ability to support healthcare document sharing is imperative in a health information exchange (HIE). Sharing imaging documents or images, however, can be challenging, especially when they are stored in a picture archiving and communication system (PACS) archive that does not support document sharing via standard HIE protocols. This research proposes a standard-compliant imaging gateway that enables connectivity between a legacy PACS and the entire HIE. Investigation of the PACS solutions used at Gil Hospital was conducted. An imaging gateway application was then developed using a Java technology stack. Imaging document sharing capability enabled by the gateway was tested by integrating it into Gil Hospital's order communication system and its HIE infrastructure. The gateway can acquire radiology images from a PACS storage system, provide and register the images to Gil Hospital's HIE for document sharing purposes, and make the images retrievable by a cross-enterprise document sharing document viewer. Development of an imaging gateway that mediates communication between a PACS and an HIE can be considered a viable option when the PACS does not support the standard protocol for cross-enterprise document sharing for imaging. Furthermore, the availability of common HIE standards expedites the development and integration of the imaging gateway with an HIE.
Ota, Sakiko; Kudo, Ken-Ichi; Taguchi, Kenta; Ihori, Mikio; Yoshie, Satoru; Yamamoto, Takuma; Sudoh, Osamu; Tsuji, Tetsuo; Iijima, Katsuya
Information and communications technology has attracted attention as a useful way of sharing care records in community-based care. Such information sharing systems, however, imposed the burden of inputting the same records into different information systems due to a lack of interoperability of the systems. The purpose of this study was to develop a gateway that links information systems and to investigate the functionality and usability of the gateway through an empirical study. We developed a gateway with healthcare and welfare professionals in Kashiwa city, Japan. The gateway system consisted of two sub-systems: a data exchange sub-system and a common sub-system. Regarding the security, we used the transport layer security 1.2 and a public key infrastructure. For document formats, we utilized the health level seven international, extensible markup language, and portable document format. In addition, we performed an empirical study with 11 scenarios of four simulated patients and a questionnaire survey to the professionals. Professionals of eight occupations participated the empirical study and verified the gateway to link information systems of six vendors. For a questionnaire survey, 32 professionals out of 40 reported that the gateway would eliminate the burden of inputting the same records into different information systems.
Siska Fadhilah Wati
Krauss, Christoph [Fraunhofer Research Institution AISEC, Garching (Germany); Sigl, Georg [Technische Univ. Muenchen (Germany); Stumpf, Frederic
Smart Meter (Gateways) are a central component of future Smart Grids and their secure operation must be ensured. In this paper, we first present several attacks on actual smart meter and gateway systems. Next, we describe a possible security solution which meets the requirements of the protection profile specified by the German Federal Office for Information Security (BIS) as far as possible with current available technology and includes additional security mechanisms. To realize a cost-efficient solution, we use off-the-shelf hardware for the mandatory Hardware Security Module (HSM) in form of a Trusted Platform Module (TPM). Finally, we give a brief overview on alternative approaches. (orig.)
Eldridge, J.; Horn, D.
The Thames Gateway, currently Europe's largest regeneration project, is an area of redevelopment located in the South East of England, with Government plans to create up to 160,000 new homes and 180,000 new jobs by 2016. Although the new development is intended to contribute £12bn annually to the economy, the potential flood risk is high, with much of the area situated on Thames tidal floodplain and vulnerable to both storm surges and peak river flows. This poses significant hazard to those inhabiting the area and has raised concern amongst the UK insurance industry, who would be liable for significant financial claims if a large flood event were to occur, particularly with respect to the number of new homes and businesses being built in flood risk areas. Flood risk and the potential damage to both lives and assets in vulnerable areas have gained substantial recognition, in light of recent flooding events, from both governmental agencies and in the public's awareness of flood hazard. This has resulted in a change in UK policy with planning policy for flood risk (PPS25, Planning Policy Statement 25) adopting a more strategic approach to development, as well as a new Flooding and Water Bill which is due for consultation in 2009. The Government and the Association of British Insurers, who represent the UK insurance industry, have also recently changed their Statement of Principles which guides provision of flood insurance in the future. This PhD research project aims to quantify flood risk in the Thames Gateway area with a view to evaluating the insurance loss potential under different insurance and planning scenarios. Using current sources of inundation extent, and incorporating varying insurance penetration rates and degrees of adoption of planning policy and guidance, it focuses on estimating flood risk under these different scenarios. This presentation introduces the development of the project and the theory and methodology which will be used to address the
Juan Vicente OLTRA GUTIÉRREZ
Full Text Available This paper presents a proposal to bring ethics and ICT closer to students of the first courses of the primary education, supporting one in each other, following the Law “Real Decreto 126/2014, 28th of February”, which establishes the basic curriculum for Primary Education. Within this Law, two of seven skills in the curriculum are established: digital skill (the third and also social and civic skills (the fifth. Given the digital natives population who are receiving education, it would be a slightly more ambitious goal to be able to glimpse them to support one in another. In this area, for example, we find a specific subject such as “Social and Civic values” with evaluation criteria such as “Employ new technologies by developing social and civic values in safe environments”. Thanks to this gateway, we can introduce small door to the vision of computer science, through ethics, which may be transversal with all subjects of the curriculum. The suggestion of the present article is to confront teachers with a vision of technology from an outside perspective, from an ethical prism, once the technology is turned it off and the mobiles or tablets screens are converted into a mere black mirror.
Kaur, Kamaljeet; Gupta, Ishu; Singh, Ashutosh Kumar
Protection of digital assets and intellectual property is becoming a challenge for most of the companies. Due to increasing availability of database services on internet, data may be insecure after passing through precarious networks. To protect intellectual property (IP) is a major concern for today's organizations, because a leakage that compromises IP means, sensitive information of a company is in the hands of biggest competitors. Electronic information processing and communication is replacing paper in many applications increasingly. Instead of paper, an email is being used for communication at workplace and from social media logins to bank accounts. Nowadays an email is becoming a mainstream business tool. An email can be misused to leave company’s sensitive data open to compromise. So, it may be of little surprise that attacks on emails are common. So, here we need an email protection system (EPS) that will protect information to leave organization via mail. In this paper, we developed an algorithm that will offer email protection via gateway during data transfer. This algorithm matches the patterns with the keywords stored in the database and then takes the actions accordingly to protect the data. This paper describes why email protection is important? How companies can protect their confidential information from being leaked by insiders.
Burke, Mark; Zangenehpour, Shahin; Bouskila, Joseph; Boire, Denis; Ptito, Maurice
The visual system in humans is considered the gateway to the world and plays a principal role in the plethora of sensory, perceptual and cognitive processes. It is therefore not surprising that quality of vision is tied to quality of life . Despite widespread clinical and basic research surrounding the causes of visual disorders, many forms of visual impairments, such as retinitis pigmentosa and macular degeneration, lack effective treatments. Non-human primates have the closest general features of eye development to that of humans. Not only do they have a similar vascular anatomy, but amongst other mammals, primates have the unique characteristic of having a region in the temporal retina specialized for high visual acuity, the fovea(1). Here we describe a general technique for dissecting the primate retina to provide tissue for retinal histology, immunohistochemistry, laser capture microdissection, as well as light and electron microscopy. With the extended use of the non-human primate as a translational model, our hope is that improved understanding of the retina will provide insights into effective approaches towards attenuating or reversing the negative impact of visual disorders on the quality of life of affected individuals.
Viana-Ferreira, Carlos; Guerra, António; Silva, João F; Matos, Sérgio; Costa, Carlos
Historically, medical imaging repositories have been supported by indoor infrastructures. However, the amount of diagnostic imaging procedures has continuously increased over the last decades, imposing several challenges associated with the storage volume, data redundancy and availability. Cloud platforms are focused on delivering hardware and software services over the Internet, becoming an appealing solution for repository outsourcing. Although this option may bring financial and technological benefits, it also presents new challenges. In medical imaging scenarios, communication latency is a critical issue that still hinders the adoption of this paradigm. This paper proposes an intelligent Cloud storage gateway that optimizes data access times. This is achieved through a new cache architecture that combines static rules and pattern recognition for eviction and prefetching. The evaluation results, obtained from experiments over a real-world dataset, show that cache hit ratios can reach around 80%, leading to reductions of image retrieval times by over 60%. The combined use of eviction and prefetching policies proposed can significantly reduce communication latency, even when using a small cache in comparison to the total size of the repository. Apart from the performance gains, the proposed system is capable of adjusting to specific workflows of different institutions.
Rozwadowski, Kevin; Yang, Wen; Kagale, Sateesh
Employing genomic DNA clones to characterise gene attributes has several advantages over the use of cDNA clones, including the presence of native transcription and translation regulatory sequences as well as a representation of the complete repertoire of potential splice variants encoded by the gene. However, working with genomic DNA clones has traditionally been tedious due to their large size relative to cDNA clones and the presence, absence or position of particular restriction enzyme sites that may complicate conventional in vitro cloning procedures. To enable efficient cloning and manipulation of genomic DNA fragments for the purposes of gene expression and reporter-gene studies we have combined aspects of the Gateway system and a bacteriophage-based homologous recombination (i.e. recombineering) system. To apply the method for characterising plant genes we developed novel Gateway and plant transformation vectors that are of small size and incorporate selectable markers which enable efficient identification of recombinant clones. We demonstrate that the genomic coding region of a gene can be directly cloned into a Gateway Entry vector by recombineering enabling its subsequent transfer to Gateway Expression vectors. We also demonstrate how the coding and regulatory regions of a gene can be directly cloned into a plant transformation vector by recombineering. This construct was then rapidly converted into a novel Gateway Expression vector incorporating cognate 5' and 3' regulatory regions by using recombineering to replace the intervening coding region with the Gateway Destination cassette. Such expression vectors can be applied to characterise gene regulatory regions through development of reporter-gene fusions, using the Gateway Entry clones of GUS and GFP described here, or for ectopic expression of a coding region cloned into a Gateway Entry vector. We exemplify the utility of this approach with the Arabidopsis PAP85 gene and demonstrate that the expression
Aboulela, Mostafa; Tanaka, Yuji; Nishimura, Kohji; Mano, Shoji; Kimura, Tetsuya; Nakagawa, Tsuyoshi
Analyses of the subcellular localization of proteins and protein-protein interaction networks are essential to uncover the molecular basis of diverse biological processes in plants. To this end, we have created a Gateway cloning-compatible vector system, named dual-site (DS) Gateway cloning system to allow simple cloning of two expression cassettes in a binary vector and to express them simultaneously in plant cells. In the DS Gateway cloning system, (i) a moderate constitutive nopaline synthase promoter (Pnos), which is much suitable for localization analysis, is used to guide each expression cassette, (ii) four series of vectors with different plant resistance markers are established, (iii) N-terminal fusion with 6 fluorescent proteins and 7 epitope tags is available, (iv) both N- and C-terminal fusions with split enhanced yellow fluorescent protein (EYFP) are possible for efficient detection of protein-protein interactions using a bimolecular fluorescence complementation (BiFC) assay. The usefulness of the DS Gateway cloning system has been demonstrated by the analysis of the expression and the subcellular localization patterns of two Golgi proteins in stable expression system using A. thaliana, and by the analyses of interactions between subunits of coat protein complex II (COPII) both in transient and stable expression systems using Japanese leek and A. thaliana, respectively. The DS Gateway cloning system provides a multipurpose, efficient expression tool in gene function analyses and especially suitable for investigating interactions and subcellular localization of two proteins in living plant cells. Copyright © 2017 Elsevier Inc. All rights reserved.
Guan, Kai; Shao, Minggang; Wu, Shuicai
This paper proposed a remote health monitoring system for the elderly based on smart home gateway. The proposed system consists of three parts: the smart clothing, the smart home gateway, and the health care server. The smart clothing collects the elderly's electrocardiogram (ECG) and motion signals. The home gateway is used for data transmission. The health care server provides services of data storage and user information management; it is constructed on the Windows-Apache-MySQL-PHP (WAMP) platform and is tested on the Ali Cloud platform. To resolve the issues of data overload and network congestion of the home gateway, an ECG compression algorithm is applied. System demonstration shows that the ECG signals and motion signals of the elderly can be monitored. Evaluation of the compression algorithm shows that it has a high compression ratio and low distortion and consumes little time, which is suitable for home gateways. The proposed system has good scalability, and it is simple to operate. It has the potential to provide long-term and continuous home health monitoring services for the elderly.
Full Text Available A smart home gateway plays an important role in the Internet of Things (IoT system that takes responsibility for the connection between the network layer and the ubiquitous sensor network (USN layer. Even though the home network application is developing rapidly, researches on the home gateway based open development architecture are less. This makes it difficult to extend the home network to support new applications, share service, and interoperate with other home network systems. An integrated access gateway (IAGW is proposed in this paper which upward connects with the operator machine-to-machine platform (M2M P/F. In this home network scheme, the gateway provides standard interfaces for supporting various applications in home environments, ranging from on-site configuration to node and service access. In addition, communication management ability is also provided by M2M P/F. A testbed of a simple home network application system that includes the IAGW prototype is created to test its user interaction capabilities. Experimental results show that the proposed gateway provides significant flexibility for users to configure and deploy a home automation network; it can be applied to other monitoring areas and simultaneously supports a multi-ubiquitous sensor network.
Cooper, J. F.; Kauristie, K.; Weatherwax, A. T.; Sheehan, G. W.; Smith, R. W.; Cline, T. D.; Lewis, E. M.; Haines-Stiles, G.
The Polar Gateways conference was hosted during January 23-29, 2008, the first week of polar sunrise at Barrow, Alaska, at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium (BASC). The dawn week of polar day, the highly variable low temperatures, and the ice-covered shore tundra and adjacent sea ice conditions provided an appropriate locale for a conference dedicated in the spirit of the International Polar and Heliophysical Years 2007-2009 to the educational exploration of polar and icy world science of Earth and the solar system. The many scientific, educational, and cultural interactions with the local community of four thousand residents, sixty percent native Inupiat Eskimo, further provided an unforgettable experience of what life might be someday be like on other remote polar and icy worlds to be explored and eventually inhabited. Over one hundred active participants, more than half participating remotely, contributed science presentations and educational activities during this unique circumpolar and very "green" conference. Most remote contributions came via videoconference from the Swedish Institute of Space Physics (IRF) at Kiruna, Sweden, the EISCAT Svalbard Radar Facility at Spitzbergen, Norway, the University of Alaska at Fairbanks, NASA Goddard Space Flight Center and the Jet Propulsion Laboratory, the University of California at Berkeley, and the University of Arizona. A few contributors participated via teleconference, including one from the Polar Geophysical Institute at Apatity in Russia. These active contributions spanned up to thirteen time zones (Alaska to Russia) at various times during the conference. Primary videoconferencing support between Barrow and other sites was ably provided by the University of Alaska at Fairbanks, and local operators at each remote site collectively made this conference possible. Science presentations spanned the solar system from the polar Sun and heliospheric environment to Earth, Moon
Akre, Christina; Suris, Joan-Carles
Electronic cigarettes (ECs) acting as a gateway to smoking traditional cigarettes (TCs) is a growing public health concern of EC use among youths. To gather the opinions and perceptions of adolescents and young adults (AYAs) on whether and how EC can act as a gateway to smoking TC among youths. A qualitative method included 42 AYAs. Participants…
Otten, R.; Mun, C.J.; Dishion, T.J.
Background: There is limited empirical integration between peer clustering theory and the Gateway framework. The goal of the present study was to test the hypothesis that friendship associations partly predict gateway escalations in the use of drugs from adolescence to adulthood. Method: This
... DEPARTMENT OF DEFENSE Department of the Army; United States Corps of Engineers Notice of Intent To Prepare a Joint Environmental Impact Statement (EIS) for the Gateway Pacific Terminals Bulk Dry Goods..., received permit applications for Pacific International Terminal, Inc.'s Gateway Pacific Terminal (GPT) and...
Full Text Available Sum up accident sacrifice at January period of up to August 2007 progressively mount and primary factor of cause the happening of accident is human being factor, one of them is missing driver of awareness. To lessen this accident number, one of them is earn conducted by killing car machine in order to the missing driver of awareness cannot animate its car machine as well as communications with party police. The making of information system via SMS Gateway of between party police with driver, expected to by earn to overcome the problem. In this system, there are two sides that is side of driver and side police. Data of co-ordinate of position vehicle taken by GPS then is delivered through SMS of through server/police. That Data co-ordinate then is presented at digital map. Data of number Vehicle delivered through SMS to server and kept in database. With exploiting technology GPS (Global Positioning System, Microcontroller, GSM Modem, MapInfo, and Microsoft Office Access for the data intake, conducted a examination several times in place which equal to time difference about minute half, so that be got by a difference apart between position result of examination with data of reference of Google Earth of equal to more or less one meter. Others also be happened by the data deviation between position got from intake of data GPS with position vehicle which in fact (reference data from Google Earth. The based on result of examination which have been conducted in place location park D3 PENS ITS differ from position vehicle which in fact and happened by the position deviation more or less four transversal meter on course south (- 7,165614° and the east longitude (112,476011°.
Alonso, Victoria L; Ritagliati, Carla; Cribb, Pamela; Serra, Esteban C
We present here three expression plasmids for Trypanosoma cruzi adapted to the Gateway® recombination cloning system. Two of these plasmids were designed to express trypanosomal proteins fused to a double tag for tandem affinity purification (TAPtag). The TAPtag and Gateway® cassette were introduced into an episomal (pTEX) and an integrative (pTREX) plasmid. Both plasmids were assayed by introducing green fluorescent protein (GFP) by recombination and the integrity of the double-tagged protein was determined by western blotting and immunofluorescence microscopy. The third Gateway adapted vector assayed was the inducible pTcINDEX. When tested with GFP, pTcINDEX-GW showed a good response to tetracycline, being less leaky than its precursor (pTcINDEX).
Karna, S L Rajasekhar; Zogaj, Xhavit; Barker, Jeffrey R; Seshu, Janakiram; Dove, Simon L; Klose, Karl E
Comprehensive clone sets representing the entire genome now exist for a large number of organisms. The Gateway entry clone sets are a particularly useful means to study gene function, given the ease of introduction into any Gateway-suitable destination vector. We have adapted a bacterial two-hybrid system for use with Gateway entry clone sets, such that potential interactions between proteins encoded within these clone sets can be determined by new destination vectors. We show that utilizing the Gateway clone sets for Francisella tularensis and Vibrio cholerae, known interactions between F. tularensis IglA and IglB and V. cholerae VipA and VipB could be confirmed with these destination vectors. Moreover, the introduction of unique tags into each vector allowed for visualization of the expressed hybrid proteins via Western immunoblot. This Gateway-suitable bacterial two-hybrid system provides a new tool for rapid screening of protein-protein interactions.
Universities have been providing Continuing Education and Professional Development for adults since XIX century. Most universities have been developing activities beyond educating young students and researching towards providing training and education for adults. Universities have been researching and cooperating to develop structures, procedures, teaching methods, fora and know-how to provide the framework for adult education and training.
Astria, Fanny; Subito, Mery; Nugraha, Deny Wiria
PH and temperature measuring system devices based on SMS gateway is a measurement tool that communicates with the provider, so it can be used to monitor the pH level and temperature of the water in the distance. It works by using a pH sensor and a temperature detector. pH and temperature measuring devices based on SMS gateway can measure the pH level of the water with a scale between pH 0 to pH 14, whereas for temperature, it can be measured with a scale between -100C up to 1000C. To create t...
The book describes the science gateway building technology developed in the SCI-BUS European project and its adoption and customization method, by which user communities, such as biologists, chemists, and astrophysicists, can build customized, domain-specific science gateways. Many aspects of the core technology are explained in detail, including its workflow capability, job submission mechanism to various grids and clouds, and its data transfer mechanisms among several distributed infrastructures. The book will be useful for scientific researchers and IT professionals engaged in the develop
Ji, Wei; Yang, Hongliang; Liu, Yang; Liu, Yonghui; Cui, Wei
The paper proposes the design of Home Gateway used in FTTH. On the customer's side, the Home Gateway finishes the optical signal receiving, provides three kinds of interfaces for the video, voice data, and attains the integration of the three services. PAS6301 chip achieves the control of voice, video and data services. Especially on the aspect of the video services, the HG system combines the advantages of IPTV and the DVB to offer a platform for receiving two signals. Users can use ordinary TV to receive both digital TV programs encoded by MPEG-2 and IPTV programs encoded by H.264.
Mathur, Prateek; Nielsen, Rasmus Hjorth; Prasad, Neeli R.
Communicating the Internet of Things (IoT) data relying on Long-Term Evolution (LTE) and WiFi has been been presented in the relevant literature. However, this necessitates devices to have LTE/WiFi capability of their own, that has limitations in the form of power consumption, and radio access...... the data to the Internet. In this paper we present a system model wherein the smartphone functions as a gateway for the IoT devices operating on NFC, ZigBee and Bluetooth. The smartphone functioning as a gateway for transferring IoT data. The system modelled in the form of a Markov Chain based...
Nakutis, Z.; Deksnys, V.; Jaurusevicius, I.
The publication presents a system architecture for remote agriculture process automation, involving sensors and actuators connected to IoT gateway running OPC UA server. Sensors and actuators are very general and do not need any intelligence related to the process under control. Acquired data....../actuators. Throughput of data collection channel (long range radio) and IoT gateway performance are limiting factors for real time control or observation of agriculture processes. Therefore, achievable channel "sensors-OPC UA server" throughput is investigated experimentally. Potential agriculture applications that may...
Kandel, Denise; Kandel, Eric
The Gateway Hypothesis describes how tobacco or alcohol use precedes marijuana and other illicit drug use. We review the epidemiological data, explore the underlying molecular mechanisms in mice and discuss the societal implications of the hypothesis, including the use of e-cigarettes by young people. Our mouse model identifies biological processes underlying the hypothesis, showing that nicotine is a gateway drug that exerts a priming effect on cocaine through increased global acetylation in the striatum. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Full Text Available The structure of competitiveness between hub ports in the multipolar Northeast Asian system will determine which ports achieve regional gateway status. A survey instrument to assess 21 measurement items generated 203 responses from Shanghai, Hong Kong and Busan. Exploratory factor analysis revealed a valid and reliable competitiveness construct underpinning 19 measurement scales and a four-factor model incorporating availability, operational efficiency, port costs and service quality. Differences in factor importance revealed that success as a regional gateway port depends on a port area developing strategically into a multi-functional business centre. The model offers a management tool to guide future port improvement.
Neumann, Joerg [SSV Software Systems GmbH, Hannover (Germany). Bereich Vertrieb und Marketing
The way to a smart grid leads via the interconnection of distributed energy producers and consumers. Within the total network, energy producers and consumers have to communicate meaningfully with each other. This is a great performance for a reliable and performant long-distance service. In the case of 2G Energietechnik AG (Heek, Federal Republic of Germany), SSV Software Systems GmbH (Hannover, Federal Republic of Germany) has met this challenge with an ICT-based gateway solution mastered.
Spinuso, Alessandro; Trani, Luca; Kamb, Linus; Frobert, Laurent
One of the NERIES EC project main objectives is to establish and improve the networking of seismic waveform data exchange and access among four main data centers in Europe: INGV, GFZ, ORFEUS and IPGP. Besides the implementation of the data backbone, several investigations and developments have been conducted in order to offer to the users the data available from this network, either programmatically or interactively. One of the challenges is to understand how to enable users` activities such as discovering, aggregating, describing and sharing datasets to obtain a decrease in the replication of similar data queries towards the network, exempting the data centers to guess and create useful pre-packed products. We`ve started to transfer this task more and more towards the users community, where the users` composed data products could be extensively re-used. The main link to the data is represented by a centralized webservice (SeismoLink) acting like a single access point to the whole data network. Users can download either waveform data or seismic station inventories directly from their own software routines by connecting to this webservice, which routes the request to the data centers. The provenance of the data is maintained and transferred to the users in the form of URIs, that identify the dataset and implicitly refer to the data provider. SeismoLink, combined with other webservices (eg EMSC-QuakeML earthquakes catalog service), is used from a community gateway such as the NERIES web portal (http://www.seismicportal.eu). Here the user interacts with a map based portlet which allows the dynamic composition of a data product, binding seismic event`s parameters with a set of seismic stations. The requested data is collected by the back-end processes of the portal, preserved and offered to the user in a personal data cart, where metadata can be generated interactively on-demand. The metadata, expressed in RDF, can also be remotely ingested. They offer rating
Francoeur, H.; Muench, J.; Okaya, D.; Maechling, P.; Deelman, E.; Mehta, G.
SCEC Earthworks is a scientific gateway designed to provide community wide access to the TeraGrid. Earthworks provides its users with a portal based interface for easily running anelastic wave propagation (AWM) simulations. Using Gridsphere and several portlets developed as a collaborative effort with IRIS, Earthworks enables users to run simulations without any knowledge of the underlying workflow technology needed to utilize the TeraGrid. The workflow technology behind Earthworks has been developed as a collaborative effort between SCEC and the Information Sciences Institute (ISI). Earthworks uses a complex software stack to translate abstract workflows defined by the user into a series of jobs that run on a number of computational resources. These computational resources include a combination of servers provided by SCEC, USC High Performance Computing Center and NSF TeraGrid supercomputer facilities. Workflows are constructed after input from the user is passed via a Java based interface to the Earthworks backend, where a DAX (directed acyclic graph in XML) is generated. This DAX describes each step of the workflow including its inputs, outputs, and arguments, as well as the parent child relationships between each process. The DAX is then handed off to the Virtual Data System (VDS) and Pegasus provided by ISI, which translate it from an abstract workflow to a concrete workflow by filling in logical file and application names with their physical path and location. This newly created DAG (directed acyclic graph) is handed off to the Condor scheduler. The bottom part of the software stack is a Globus installation at each site the provides local transfer and resource management capabilities. Resources across different sites are transparently managed and tracked by VDS which allows greater flexibility in running the workflows. After a workflow is completed, products and metadata are registered with integrated data management tools. This allows for metadata querying
Andries G. van Aarde
Full Text Available The article is a contribution to the centennial celebration of the Faculty of Theology at the University of Pretoria. It forms part of the section in the programme titled ‘Ethos – Critical perspectives on our past and a gateway to our future’ and is dedicated to Yolanda Dreyer who was the first female professor appointed in the Faculty of Theology of the University of Pretoria. The article reflects on aspects of the present-day populist discourse in South Africa and globally, which is enhanced by neonationalistic separatism. The following issues are critically discussed: homophobia regarding sexual minorities, a lack of sensitivity for the negative effects of male domination and the objection to English as the lingua franca for teaching. These aspects are assessed against the background of the Derridean notion of ‘deconstruction’ and the contributions of the first professors employed in the Faculty of Theology since its inception in 2017.
Roger E. HAMLIN; Dan T. LAZĂR
World trade and transportation are changing dramatically. Energy prices and transport sustainability concerns are reinvigorating ocean freighter shipping. An ever-increasing portion of trade is in containers, and container ships are getting larger quickly. Many ports, nations and continents are not keeping up with ship size increases putting them at a trade disadvantage. Major canals and seaways must also upgrade or be rendered obsolete, causing a change in the pattern of world trade. Ports h...
Rapetti, D.; Tauscher, K.; Burns, J. O.; Switzer, E.; Mirocha, J.; Furlanetto, S.; Monsalve, R.
The Deep Space Gateway will provide a unique opportunity for low-frequency radio telescopes shielded by the Moon to study the unexplored Cosmic Dawn, which our novel pipeline is able to constrain by extracting the spectrum of a neutral hydrogen line.
Wilkerson, A. M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McCullough, J. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments.
von der Heydt, A.S.|info:eu-repo/dai/nl/245567526; Dijkstra, H.A.|info:eu-repo/dai/nl/073504467
Both geological data and climate model studies indicate that substantially different patterns of the global ocean circulation have existed throughout the Cenozoic. In a climate model study of the late Oligocene [von der Heydt, A., Dijkstra, H.A. (2006). Effect of ocean gateways on the global ocean
Full Text Available In recent years, the increased interest in energy conservation and environmental protection, combined with the development of modern communication and computer technology, has resulted in the replacement of distributed heating by central heating in urban areas. This paper proposes a Representational State Transfer (REST Machine-to-Machine (M2M gateway for wireless remote monitoring for a district central heating network. In particular, we focus on the resource-oriented RESTful M2M gateway architecture, and present an uniform devices abstraction approach based on Open Service Gateway Initiative (OSGi technology, and implement the resource mapping mechanism between resource address mapping mechanism between RESTful resources and the physical sensor devices, and present the buffer queue combined with polling method to implement the data scheduling and Quality of Service (QoS guarantee, and also give the RESTful M2M gateway open service Application Programming Interface (API set. The performance has been measured and analyzed. Finally, the conclusions and future work are presented.
Suc, Jean Pierre; Popescu, Speranta Maria; Do Couto, Damien; Clauzon, Georges; Rubino, Jean Loup; Melinte-Dobrinescu, Mihaela Carmen; Quillévéré, Frédéric; Brun, Jean Pierre; Dumurdžanov, Nikola; Zagorchev, Ivan; Lesić, Vesna; Tomić, Dragana; Sokoutis, Dimitrios; Meyer, Bertrand; Macaleţ, Rodica; Rifelj, Helena
Since the discovery of calcareous nannofossils, dinoflagellate cysts and planktonic foraminifers in deposits from the Dacic Basin, intensive research has been performed in order to evidence which gateway this microplankton used to connect Paratethys and the Mediterranean prior and after the
Archer, Candace C.; Miller, Melissa K.
Prior research in political science and other disciplines demonstrates the pedagogical and practical benefits of active learning. Less is known, however, about the extent to which active learning is used in political science classrooms. This study assesses the prioritization of active learning in "gateway" political science courses, paying…
Archinal, B.; Gaddis, L.; Kirk, R.; Edmundson, K.; Stone, T.; Portree, D.; Keszthelyi, L.
The Deep Space Gateway, in low lunar orbit, could be used to achieve a long standing goal of lunar science, collecting stereo images in two months to make a complete, uniform, high resolution, known accuracy, global topographic model of the Moon.
E. I. Goncharov
Full Text Available When personal data exchange between informational systems takes place, one must guarantee the systems are not integrating but just interacting. This task can not be accomplished by using traditional tools such as firewalls, cryptography and so on. To solve the problem we suggest deploying of informational gateway in personal data exchange process.
Examines the World Bank Internet initiative, the Development Gateway. Describes the importance of the Bank as a knowledge bank and the threats posed by the Internet to its near monopoly of development thinking. Argues that the initiative reveals biases and misunderstandings in the World Bank's approach to knowledge for development. (CAJ)
Ouellette, S. P.; Gauliard, E.; Antošová, Zuzana; Ladant, D.
Roč. 6, č. 3 (2014), s. 259-267 ISSN 1758-2229 Institutional support: RVO:67985823 Keywords : bacterial two-hybrid system * protein–protein interactions * cell division * Gateway((R))(GW) cloning system Subject RIV: EE - Microbiology, Virology Impact factor: 3.293, year: 2014
The exhibit Puerto Rico: Gateway to Landscape proposes to explore various ways in which citizens approach the landscape, or construct it â inside and outside the city â and considers city planning, the creation of parks and natural reserves, and their interpretation. From a perspective of citizen involvement, this thematic scaffolding related to landscape and the...
Seven years ago, SC Johnson--A Family Company approached Gateway Technical College with a need to further strengthen their incumbent workforce's technical training and education. Retirements, brain drain, and competition for technical expertise were the forces driving SC Johnson to develop a comprehensive, flexible, and timely workplace education…
Cheng, Bo; Wei, Zesan
In recent years, the increased interest in energy conservation and environmental protection, combined with the development of modern communication and computer technology, has resulted in the replacement of distributed heating by central heating in urban areas. This paper proposes a Representational State Transfer (REST) Machine-to-Machine (M2M) gateway for wireless remote monitoring for a district central heating network. In particular, we focus on the resource-oriented RESTful M2M gateway architecture, and present an uniform devices abstraction approach based on Open Service Gateway Initiative (OSGi) technology, and implement the resource mapping mechanism between resource address mapping mechanism between RESTful resources and the physical sensor devices, and present the buffer queue combined with polling method to implement the data scheduling and Quality of Service (QoS) guarantee, and also give the RESTful M2M gateway open service Application Programming Interface (API) set. The performance has been measured and analyzed. Finally, the conclusions and future work are presented.
Jenkins, Rick; Butler, Sharon
In higher education in the state of Arkansas, two courses are considered to be gateway courses to obtaining a college degree--College Algebra and English Composition I. While students may obtain Certificates of Proficiency and Technical Certificates without taking these courses, few, if any, can earn an Associate's or Bachelor's degree without…
Wang, Gui-Fang; Qi, Bing; Tu, Lei-Lei; Liu, Lian; Yu, Guo-Cheng; Zhong, Jing-Xiang
To construct adenovirus vectors of lumican gene by gateway recombinant cloning technology to further understand the role of lumican gene in myopia. Gateway recombinant cloning technology was used to construct adenovirus vectors. The wild-type (wt) and mutant (mut) forms of the lumican gene were synthesized and amplified by polymerase chain reaction (PCR). The lumican cDNA fragments were purified and ligated into the adenovirus shuttle vector pDown-multiple cloning site (MCS)-/internal ribozyme entry site (IRES)/enhanced green fluorescent protein (EGFP). Then the desired DNA fragments were integrated into the destination vector pAV.Des1d yielding the final expression constructs pAV.Ex1d-cytomegalovirus (CMV)>wt-lumican/IRES/EGFP and pAV.Ex1d-CMV>mut-lumican/IRES /EGFP, respectively. The adenovirus plasmids pAV.Ex1d-CMV>wt-lumican/IRES/EGFP and pAV.Ex1d-CMV>mut-lumican/IRES/EGFP were successfully constructed by gateway recombinant cloning technology. Positive clones identified by PCR and sequencing were selected and packaged into recombinant adenovirus in HEK293 cells. We construct adenovirus vectors containing the lumican gene by gateway recombinant cloning technology, which provides a basis for investigating the role of lumican gene in the pathogenesis of high myopia.
Bell, Kirsten; Keane, Helen
The idea that drug use in 'softer' forms leads to 'harder' drug use lies at the heart of the gateway theory, one of the most influential models of drug use of the twentieth century. Although hotly contested, the notion of the 'gateway drug' continues to rear its head in discussions of drug use--most recently in the context of electronic cigarettes. Based on a critical reading of a range of texts, including scholarly literature and media reports, we explore the history and gestation of the gateway theory, highlighting the ways in which intersections between academic, media and popular accounts actively produced the concept. Arguing that the theory has been critical in maintaining the distinction between 'soft' and 'hard' drugs, we turn to its distinctive iteration in the context of debates about e-cigarettes. We show that the notion of the 'gateway' has been transformed from a descriptive to a predictive model, one in which nicotine is constituted as simultaneously 'soft' and 'hard'--as both relatively innocuous and incontrovertibly harmful. Copyright © 2014 Elsevier Ltd. All rights reserved.
Arima, Yasunobu; Kamimura, Daisuke; Atsumi, Toru; Murakami, Masaaki
Inflammation is observed in many diseases and disorders. We discovered a key machinery of inflammation, the inflammation amplifier, which is induced by the simultaneous activation of NFκB and STAT3 followed by the hyper-activation of NFκB in non-immune cells, including endothelial cells and fibroblasts. Since that discovery, we found the Gateway Reflex, which describes regional neural activations that enhance the inflammation amplifier to create a gateway for immune cells to bypass the blood-brain barrier. In addition, we have identified over 1,000 positive regulators and over 500 targets of the inflammation amplifier, which include a significant numbers of human disease-associated genes. In parallel, we performed a comprehensive analysis of human disease samples and found that the inflammation amplifier was activated during the development of chronic inflammation. Thus, we concluded that the inflammation amplifier is associated with various human diseases and disorders, including autoimmune diseases, metabolic syndromes, neurodegenerative diseases, and other inflammatory diseases. We are now attempting drug discovery for inflammatory diseases and disorders based on the inflammation amplifier and Gateway Reflex. In this review, we discuss the Gateway Reflex as an example for the neuro-immune interaction in vivo.
Allenbaugh, R. J.; Herrera, K. M.
Determining student readiness for gateway chemistry courses and providing underprepared students effective remediation are important as student bodies are growing increasingly diverse in their precollege preparation. The effectiveness of the ACT Mathematics Test and the Whimbey Analytical Skills Inventory (WASI) in predicting student success in…
Parental involvement plays an important role in the academic success of children. Schools in new gateway states where there has not been a longstanding tradition of immigration often lack the cultural knowledge and linguistic resources necessary to serve immigrant youth and their families effectively. By examining the experiences of Mexican…
Nayegandhi, Amar; Vivekanandan, Saisudha; Brock, John C.; Stevens, Sara; Wright, C. Wayne; Bonisteel, Jamie M.; Nagle, David B.; Yates, Xan; Klipp, Emily S.
This DVD contains lidar-derived bare-earth (BE) and first-surface (FS) topography GIS datasets of a portion of the Gateway National Recreation Area in New Jersey and New York. These datasets were acquired July 8-9, 2009.
Hilburn, Jeremy Dale
This qualitative study examines Civics teachers' perceptions of working with immigrant students in a new gateway state. By analyzing collective case studies of six teachers in central North Carolina, from different types of schools and with different professional backgrounds, this study is positioned to make recommendations for social studies…
Javore, Barbara B.
Terezin, the gateway to Auschwitz, a town commandeered by the Nazis to serve as a "model" relocation camp to demonstrate the Third Reich's generosity and kindness toward the Jews, was an elaborate hoax. In an environment where truth was twisted beyond recognition, artists, writers, actors, and musicians used their work to revive the…
Fries, M.; Fisher, K.
The Deep Space Gateway can allow direct analysis of dust from over a dozen comets, using an instrument similar to the successful Cassini Dust Analyzer (CDA). Long-term measurements are preferred. Compositions of over a dozen asteroids and comets can be obtained.
Alhammoud, B.; Meijer, P.Th.; Dijkstra, H.A.
The Neogene sedimentary record of the Mediterranean Sea holds evidence for changes in water properties and circulation. These paleoceanographic changes have been attributed to changes in the flow through the ocean gateway between the Mediterranean Sea and the Atlantic Ocean. We use an oceanic
Mehrabi, Rahim; Mirzadi Gohari, Amir; Silva, da Gilvan Ferreira; Steinberg, Gero; Kema, Gert H.J.; Wit, de Pierre J.G.M.
Genetic manipulation of fungi requires quick, low-cost, efficient, high-throughput and molecular tools. In this paper, we report 22 entry constructs as new molecular tools based on the Gateway technology facilitating rapid construction of binary vectors that can be used for functional analysis of
Miller, Naomi J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
At the offices of the accounting firm of DeJoy, Knauf & Blood, LLP in Rochester, NY, the GATEWAY program evaluated a new lighting system that incorporates a number of different OLED luminaires. Evaluation of the OLED products included efficacy performance, field measurements of panel color, flicker measurements, and staff feedback.
Potgieter, Ferdinand J.; van der Walt, Johannes L.; Wolhuter, Charl C.
As part of a research project on religion, spirituality and education, the authors attended to the role that children's divine dreams could play in religious education (RE). They contend that such dreams can indeed be used by RE teachers as the gateway to understanding the spirituality of their learners. They defend their claim by firstly…
Miller, Naomi J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
At the offices of Aurora Lighting Design, Inc., in Grayslake, IL, the GATEWAY program conducted its first investigation involving OLED lighting. The project experienced several challenges, but also highlighted a number of promising attributes – which indicate that with continued improvements in efficacy, longevity, size, and flexibility, OLEDs could provide a new tool for creative and effective lighting.
Laske, Gabi; Berger, Jon; Orcutt, John; Babcock, Jeff
We describe an autonomously deployable, communications gateway designed to provide long-term and near real-time data from ocean observatories. The key features of this new system are its abilities to telemeter sensor data from the seafloor to shore without cables or moorings, and to be deployed without a ship, thereby greatly reducing life-cycle costs. The free-floating surface communications gateway utilizes a Liquid Robotics wave glider comprising a surfboard-sized float towed by a tethered, submerged glider, which converts wave motion into thrust. For navigation, the wave glider is equipped with a small computer, a GPS receiver, a rudder, solar panels and batteries, and an Iridium satellite modem. Acoustic communications connect the subsea instruments and the surface gateway while communications between the gateway and land are provided by the Iridium satellite constellation. Wave gliders have demonstrated trans-oceanic range and long-term station keeping capabilities. The acoustics communications package is mounted in a shallow tow body which utilizes a WHOI micro modem and a Benthos low frequency, directional transducer. A matching modem and transducer is mounted on the ocean bottom package. Tests of the surface gateway in 4350 m of water demonstrated an acoustic efficiency of approximately 396 bits/J. For example, it has the ability to send 4 channels of compressed, 1 sample per second data from the ocean bottom to the gateway with an average power draw of approximately 0.15 W and a latency of less than 3 minutes. This gateway is used to send near real-time data from a broadband ocean bottom seismic observatory, first during short week-to-months long test deployments but will ultimately be designed for a two-year operational life. Such data from presently unobserved oceanic areas are critical for both national and international agencies in monitoring and characterizing earthquakes, tsunamis, and nuclear explosions. We present initial results from a two short
Guo, Zhaolai; Sun, Xudong; Xu, Huini
The inducible vectors pER8-Gateway-3Flag and pER8-Gateway-3Flag-SRDX have been subjected to considerable research in terms of the function of transcription factors (TFs) via transcription activity and repression, respectively. Approximately 1500 TFs have been identified in Arabidopsis thaliana genome. To identify their functions, loss-of-function and gain-of-function mutants were generated to analyze the phenotype. However, many loss-of-function mutants did not show any evident phenotype because of the functional redundancy within the TF family. The constitutive misexpression of some TFs may result in lethality or sterility. To overcome these problems, we produced a Gateway-compatible inducible binary vector system that facilitates fast and reliable DNA cloning and biological function identification. The vector can be used for the inducible expression of protein fusions to a polypeptide protein tag named 3xFLAG tag. This vector system can also be used to generate an inducible transcription inhibition of protein fusion to an Ethylene-Responsive Factor-associated amphiphilic repression (EAR) motif. The EAR motif makes it possible to get rid of redundancy within a TF family, thereby facilitating studies on loss of function. With these Gateway vectors, conventional subcloning technology that depends on restriction digestion and ligation is avoided. Thus, these Gateway vectors should be useful not only for the rapid analysis of the functions of redundant plant TFs, but also for the manipulation of TF overexpression, resulting in plant lethality or sterility, via an inducible promoter.
Sato, K. Y.; Tomko, D. L.; Levine, H. G.; Quincy, C. D.; Rayl, N. A.; Sowa, M. B.; Taylor, E. M.; Sun, S. C.; Kundrot, C. E.
Model organisms are foundational for conducting physiological and systems biology research to define how life responds to the deep space environment. The organisms, areas of research, and Deep Space Gateway capabilities needed will be presented.
This Final Architecture and Design report has been prepared to describe the structure and design of all the system : components for the LA-Gateway FRATIS Demonstration Project. More specifically, this document provides: : Detailed descriptions of...
The Volpe National Transportation Systems Center (Volpe Center) is providing technical : support to Sandy Hook, a unit of the Gateway National Recreation Area, in the planning and : concept development for possible Intelligent Transportation Systems ...
This Demonstration Plan has been prepared to provide guidance and a common definition to all parties of the : testing program that will be conducted for the LA-Gateway FRATIS Demonstration Project. More specifically, this : document provides: : P...
Bourassa, M.; Osinski, G. R.; Cross, M.; Hill, P.; King, D.; Morse, Z.; Pilles, E.; Tolometti, G.; Tornabene, L. L.; Zanetti, M.
Canadian contributions to the science goals and objectives of a lunar precursor rover for HERACLES, an international mission concept, are discussed. Enabled by the Deep Space Gateway, this rover is a technical demonstrator for robotic sample return.
Fernandez-Valdivielso, Carlos; Matias, Ignacio R.; Arregui, Francisco J.; Bariain, Candido; Lopez-Amo, Manuel
This paper presents the first optical fiber sensor gateway for integrating these special measurement devices in Home Automation Systems, concretely in those buildings that use the KNX European Intelligent Buildings Standard.
WEST, JOSHUA H.; BLUMBERG, ELAINE J.; KELLEY, NORMA J.; HILL, LINDA; SIPAN, CAROL L.; SCHMITZ, KATHERINE; KOLODY, BOHDAN; MADLENSKY, LISA; HOVELL, MELBOURNE F.
Parent and adolescent self-reports are the most common sources for measuring parenting practices. This study’s purpose was to compare how parent and adolescent reports of parenting behaviors differentially predict adolescent gateway drug use. The sample consisted of 252 Latino adolescent-parent dyads. After controlling for potential confounding influences, only adolescents’ reports about their parents’ parenting behaviors were significant and explained 38% of the variance in gateway drug use....
Wilkerson, Andrea M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sullivan, Gregory P. [Efficiency Solutions, Inc., Richland, WA (United States); Davis, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This report follows the GATEWAY Yuma Phase 1.1 Report and reflects LED system results documented two years after the demonstration began.
Wilkerson, A. M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Davis, R. G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This report follows the GATEWAY Yuma Phase 1.0 Report and reflects LED system results documented one year after the demonstration began.
Williams, Ronald C.; Klugh, Elgin L.
The legacy of deindustrialization and associated underemployment continues to plague many former industrial communities. In these spaces, universities serve as anchors providing gateways for individual economic empowerment, and as "brain centers" charged with generating solutions for societal problems. This paper explores the development…
Gannon, K L; Blitz, M A; Kovács, T; Pilling, M J; Seakins, P W
Collisional quenching of electronically excited states by inert gases is a fundamental physical process. For reactive excited species such as singlet methylene, (1)CH(2), the competition between relaxation and reaction has important implications in practical systems such as combustion. The gateway model has previously been applied to the relaxation of (1)CH(2) by inert gases [U. Bley and F. Temps, J. Chem. Phys. 98, 1058 (1993)]. In this model, gateway states with mixed singlet and triplet character allow conversion between the two electronic states. The gateway model makes very specific predictions about the relative relaxation rates of ortho and para quantum states of methylene at low temperatures; relaxation from para gateway states leads to faster deactivation independent of the nature of the collision partner. Experimental data are reported here which for the first time confirm these predictions at low temperatures for helium. However, it was found that in contrast with the model predictions, the magnitude of the effect decreases with increasing size of the collision partner. It is proposed that the attractive potential energy surface for larger colliders allows alternative gateway states to contribute to relaxation removing the dominance of the para gateway states.
The technique of Mos1-mediated Single Copy Insertion (MosSCI) now has become the essential technique which facilitates transgenic experiments for Caenohabditis elegans (C. elegans). Gateway system which is adopted to MosSCI-compatible vectors offers an advantage of simultaneous cloning with entry vectors cloned in the Gateway system format. On the other hand, the format for MosSCI-compatible vectors restricts flexibility in designing the vectors to only 3-fragment integration. Thus, construct of complex transgene such as the expression vector for translational gene fusion is tedious work even with Gateway system. We have developed the new recombination format called LeGaSCI (Library-enhanced Gateway for MosSCI) to expand the conventional 3-fragment to 4-fragment format which still retains the capacity to accept Promoterome and 3'UTRome libraries of C. elegans. In the new recombination format, 2 different Gateway format were combined. Cloning reaction for the tissue-specific expression vector of GFP-tagged protein with 3'UTR successfully occurred without any expected insertion, deletion or frame-shift mutation. Moreover, The MosSCI transgenic line was successfully generated with the construct. Collectively, we established the new Gateway system format which allows us to assemble 4-fragment insertion with the widest variety of entry clone vectors from C. elegans libraries.
Sander L van der Linden
Full Text Available There is currently widespread public misunderstanding about the degree of scientific consensus on human-caused climate change, both in the US as well as internationally. Moreover, previous research has identified important associations between public perceptions of the scientific consensus, belief in climate change and support for climate policy. This paper extends this line of research by advancing and providing experimental evidence for a "gateway belief model" (GBM. Using national data (N = 1104 from a consensus-message experiment, we find that increasing public perceptions of the scientific consensus is significantly and causally associated with an increase in the belief that climate change is happening, human-caused and a worrisome threat. In turn, changes in these key beliefs are predictive of increased support for public action. In short, we find that perceived scientific agreement is an important gateway belief, ultimately influencing public responses to climate change.
Full Text Available Currently,in the field of smart home,there is no relevant organization that yet has proposed an unified protocol standard.It increases the complexity and limitations of heterogeneous gateway software framework design that different vendor′s devices have different communication mode and protocol standards.In this paper,a serial of interfaces are provided by Linux kernel,and a virtual bus is registered under Linux.The physical device drivers are able to connect to the virtual bus.The detailed designs of the communication protocol are placed in the underlying adapters,making the integration of heterogeneous networks more natural.At the same time,designing the intelligent gateway system driver layer based on Linux bus can let the application layer be more unified and clear logical.And it also let the hardware access network become more convenient and distinct.
Full Text Available Citizen science is an approach of public participation in scientific research which has gained significant momentum in recent years. This is particularly evident in biology and environmental sciences where input from citizen scientists has greatly increased the number of publicly available observation data. However, there are still challenges in effective networking, data sharing and securing data quality. EU BON project has analyzed the citizen science landscape in Europe with regards to biodiversity research and proposes several policy recommendations. One of the recommendations is a Pan-European citizen science gateway for biodiversity data with dedicated tools for data collection and management. The prototypes of the gateway components are part of the EU BON biodiversity portal and described in current report.
Jagielski, Mateusz; Smoczyński, Marian; Adrych, Krystian
The development of minimally invasive techniques allowed access to the necrotic cavity through transperitoneal, retroperitoneal, transmural and transpapillary routes. The choice of access to walled-off pancreatic necrosis (WOPN) should depend not only on the spread of necrosis, but also on the experience of the clinical center. Herein we describe treatment of a patient with multilocular symptomatic walled-off pancreatic necrosis using minimally invasive techniques. The single transmural access (single transluminal gateway technique - SGT) to the necrotic collection of the patient was ineffective. The second gastrocystostomy was performed using the same minimally invasive technique as an extra way of access to the necrosis (multiple transluminal gateway technique - MTGT). In the described case the performance of the new technique consisting in endoscopic multiplexing transmural access (MTGT) was effective enough and led to complete recovery of the patient.
Vastardis, N.; Kampouridis, Michael; Yang, K.
Current smart-home and automation systems have reduced generality and modularity, thus confining users in terms of functionality. This paper proposes a novel system architecture and describes the implementation of a user-centric smart-home gateway that is able to support home-automation, energy usage management and reduction, as well as smart-grid operations. This is enabled through a middleware service that exposes a control API, allowing the manipulation of the home network devices and info...
Saja aasta möödumise puhul Esimesest maailmasõjast kutsus Euroopa Komisjon ellu European Film Gateway projekti EFG 1914. Projekti tulemusena on avalikkusele kättesaadav 660 tundi digiteeritud filme ja 5500 plakatit, fotot ja dokumenti. Nendega saab tutvuda aadressidel http://project.efg1914.eu ja http://www.europeanfilmgateway.eu/content/efg1914-project. Tekstile lisatud väike valik Eesti arhiivides leiduvast 2230-st projektiteemalisest fotost
Scher, Howie D; Whittaker, Joanne M; Williams, Simon E; Latimer, Jennifer C; Kordesch, Wendy E C; Delaney, Margaret L
Earth's mightiest ocean current, the Antarctic Circumpolar Current (ACC), regulates the exchange of heat and carbon between the ocean and the atmosphere, and influences vertical ocean structure, deep-water production and the global distribution of nutrients and chemical tracers. The eastward-flowing ACC occupies a unique circumglobal pathway in the Southern Ocean that was enabled by the tectonic opening of key oceanic gateways during the break-up of Gondwana (for example, by the opening of the Tasmanian Gateway, which connects the Indian and Pacific oceans). Although the ACC is a key component of Earth's present and past climate system, the timing of the appearance of diagnostic features of the ACC (for example, low zonal gradients in water-mass tracer fields) is poorly known and represents a fundamental gap in our understanding of Earth history. Here we show, using geophysically determined positions of continent-ocean boundaries, that the deep Tasmanian Gateway opened 33.5 ± 1.5 million years ago (the errors indicate uncertainty in the boundary positions). Following this opening, sediments from Indian and Pacific cores recorded Pacific-type neodymium isotope ratios, revealing deep westward flow equivalent to the present-day Antarctic Slope Current. We observe onset of the ACC at around 30 million years ago, when Southern Ocean neodymium isotopes record a permanent shift to modern Indian-Atlantic ratios. Our reconstructions of ocean circulation show that massive reorganization and homogenization of Southern Ocean water masses coincided with migration of the northern margin of the Tasmanian Gateway into the mid-latitude westerly wind band, which we reconstruct at 64° S, near to the northern margin. Onset of the ACC about 30 million years ago coincided with major changes in global ocean circulation and probably contributed to the lower atmospheric carbon dioxide levels that appear after this time.
Huang, Shuqiang; Tao, Ming
Wireless sensor network topology optimization is a highly important issue, and topology control through node selection can improve the efficiency of data forwarding, while saving energy and prolonging lifetime of the network. To address the problem of connecting a wireless sensor network to the Internet in cyber-physical systems, here we propose a geometric gateway deployment based on a competitive swarm optimizer algorithm. The particle swarm optimization (PSO) algorithm has a continuous search feature in the solution space, which makes it suitable for finding the geometric center of gateway deployment; however, its search mechanism is limited to the individual optimum (pbest) and the population optimum (gbest); thus, it easily falls into local optima. In order to improve the particle search mechanism and enhance the search efficiency of the algorithm, we introduce a new competitive swarm optimizer (CSO) algorithm. The CSO search algorithm is based on an inter-particle competition mechanism and can effectively avoid trapping of the population falling into a local optimum. With the improvement of an adaptive opposition-based search and its ability to dynamically parameter adjustments, this algorithm can maintain the diversity of the entire swarm to solve geometric K -center gateway deployment problems. The simulation results show that this CSO algorithm has a good global explorative ability as well as convergence speed and can improve the network quality of service (QoS) level of cyber-physical systems by obtaining a minimum network coverage radius. We also find that the CSO algorithm is more stable, robust and effective in solving the problem of geometric gateway deployment as compared to the PSO or Kmedoids algorithms.
Thronson, H.; Geffre, J.; Prusha, S.; Caroff, L.; Weisbin, C.
We report here on a series of ongoing studies to evaluate alternative architectures for future space science facilities and how robots, humans, and autonomous systems might be optimally used to support them. This presentation outlines one scenario -- a "Gateway" at the Earth-Moon L1 point for supporting multiple options beyond Low Earth Orbit -- plus our process for evaluating human/robotic activities to construct telescopes.
Prinz, Thomas M.; Amme, Wolfram
Although the semantics of converging OR gateways (also known as OR-joins) in business processes is far from trivial, they are frequently used. In this paper, we describe a general definition for soundness of processes guaranteeing the absence of deadlocks and no lack of synchronization for each possible OR-join semantics. Then, we derive a criterion — completeness — to evaluate existing approaches of OR-join semantics. As a result, no currently existing OR-join semantics is complete; therefor...
Summary of a GATEWAY program report that documented the performance of tunable-white LED lighting systems installed in several spaces within the ACC Care Center, a senior-care facility in Sacramento, CA. The project results included energy savings and improved lighting quality, as well as other possible health-related benefits that may have been attributable, at least in part, to the lighting changes.
Dubin, Manu J; Bowler, Chris; Benvenuto, Giovanna
In recent years, sequence-specific recombination cloning methods such as the Gateway system have become increasingly popular for (over)expressing tagged proteins in high-throughput investigations in many different organisms, including plants. Because of their versatility and ease of use, these methods have gained favor in low- and medium-throughput investigations as well. However, due to the recombination step, the resulting fusion proteins contain long and often highly charged polylinker sequences that can interfere with their physiological function. Furthermore, in some cases the gene of interest must be cloned twice (once with and once without a stop codon) for N- and C-terminal tagging. Here, we present a hybrid combinatorial cloning strategy that overcomes many of these limitations. In the first step, the gene of interest is cloned into an entry vector containing standardized cloning sites with the desired N- or C-terminal tag and an optimized polylinker sequence. A Gateway recombination reaction is used to transfer the protein-tag fusion from the entry clone to a Gateway destination vector with the desired promoter and selectable marker for the organism of interest. As experimental requirements evolve, constructs for expressing the protein of interest with the desired tag, promoter, and selectable marker or other features can rapidly and easily be created.
Full Text Available The design and generation of DNA constructs is among the necessary but generally tedious tasks for molecular biologists and, typically, the cloning strategy is restricted by available restriction sites. However, increasingly sophisticated experiments require increasingly complex DNA constructs, with an intricacy that exceeds what is achievable using standard cloning procedures. Many transgenes such as inducible gene cassettes or recombination elements consist of multiple components that often require precise in-frame fusions. Here, we present an efficient protocol that facilitates the generation of these complex constructs. The golden GATEway cloning approach presented here combines two established cloning methods, namely golden Gate cloning and Multisite Gateway(TM cloning. This allows efficient and seamless assembly as well as reuse of predefined DNA elements. The golden Gate cloning procedure follows clear and simple design rules and allows the assembly of multiple fragments with different sizes into one open reading frame. The final product can be directly integrated into the widely used Multisite Gateway(TM cloning system, granting more flexibility when using a transgene in the context of multiple species. This adaptable and streamlined cloning procedure overcomes restrictions of "classical construct generation" and allows focusing on construct design.
Mason, Lachlan; Hetherington, James; O'Reilly, Martin; Yong, May; Jersakova, Radka; Grieve, Stuart; Perez-Suarez, David; Klapaukh, Roman; Craster, Richard V.; Matar, Omar K.
Research codes are effective for illustrating complex concepts in educational fluid dynamics courses, compared to textbook examples, an interactive three-dimensional visualisation can bring a problem to life! Various barriers, however, prevent the adoption of research codes in teaching: codes are typically created for highly-specific `once-off' calculations and, as such, have no user interface and a steep learning curve. Moreover, a code may require access to high-performance computing resources that are not readily available in the classroom. This project allows academics to rapidly work research codes into their teaching via a minimalist `science gateway' framework. The gateway is a simple, yet flexible, web interface allowing students to construct and run simulations, as well as view and share their output. Behind the scenes, the common operations of job configuration, submission, monitoring and post-processing are customisable at the level of shell scripting. In this talk, we demonstrate the creation of an example teaching gateway connected to the Code BLUE fluid dynamics software. Student simulations can be run via a third-party cloud computing provider or a local high-performance cluster. EPSRC, UK, MEMPHIS program Grant (EP/K003976/1), RAEng Research Chair (OKM).
Arfiani Nur Khusna
Full Text Available SMS applications has become a promising business opportunities in the consumer and industrial markets in the world. One part that can not be separated from the SMS business is the role of an SMS Gateway, a system used by service providers to send and receive SMS automatically. Online shop tokofarah an online web business venture engaged in the production and sales of baby clothes and children. The problems that exist in the online shop tokofarah is the absence of communication between the customer and tokofarah thus reduced customer loyalty, customers are unaware of the latest promos and discounts, so the application of CRM (Customer Relationship Management is very necessary to help communication. Alternative solutions in addition to implementing CRM also develop and implement SMS technology as a service via SMS Gateway online. Where customers can easily find information on the latest promos and discounts, customers can simply type a certain key word and send it to a specific number that has been provided, the store can also inform customers about the latest promos and products through SMS brodcast. In this study, using Gammu as tools liaison between the device with a computer modem. Making the program using the programming language PHP as an interface, a database maker MySQL tools. The results of the implementation of the concept of SMS Gateway technology is that it can provide convenience for online customers shop tokofarah in knowing the promo and the latest product information and can order via SMS.
The design and generation of DNA constructs is among the necessary but generally tedious tasks for molecular biologists and, typically, the cloning strategy is restricted by available restriction sites. However, increasingly sophisticated experiments require increasingly complex DNA constructs, with an intricacy that exceeds what is achievable using standard cloning procedures. Many transgenes such as inducible gene cassettes or recombination elements consist of multiple components that often require precise in-frame fusions. Here, we present an efficient protocol that facilitates the generation of these complex constructs. The golden GATEway cloning approach presented here combines two established cloning methods, namely golden Gate cloning and Multisite GatewayTM cloning. This allows efficient and seamless assembly as well as reuse of predefined DNA elements. The golden Gate cloning procedure follows clear and simple design rules and allows the assembly of multiple fragments with different sizes into one open reading frame. The final product can be directly integrated into the widely used Multisite GatewayTM cloning system, granting more flexibility when using a transgene in the context of multiple species. This adaptable and streamlined cloning procedure overcomes restrictions of “classical construct generation” and allows focusing on construct design. PMID:24116091
Kirchmaier, Stephan; Lust, Katharina; Wittbrodt, Joachim
The design and generation of DNA constructs is among the necessary but generally tedious tasks for molecular biologists and, typically, the cloning strategy is restricted by available restriction sites. However, increasingly sophisticated experiments require increasingly complex DNA constructs, with an intricacy that exceeds what is achievable using standard cloning procedures. Many transgenes such as inducible gene cassettes or recombination elements consist of multiple components that often require precise in-frame fusions. Here, we present an efficient protocol that facilitates the generation of these complex constructs. The golden GATEway cloning approach presented here combines two established cloning methods, namely golden Gate cloning and Multisite Gateway(TM) cloning. This allows efficient and seamless assembly as well as reuse of predefined DNA elements. The golden Gate cloning procedure follows clear and simple design rules and allows the assembly of multiple fragments with different sizes into one open reading frame. The final product can be directly integrated into the widely used Multisite Gateway(TM) cloning system, granting more flexibility when using a transgene in the context of multiple species. This adaptable and streamlined cloning procedure overcomes restrictions of "classical construct generation" and allows focusing on construct design.
Full Text Available 6LoWPAN (IPv6 based Low-Power Personal Area Network is a protocol specification that facilitates communication of IPv6 packets on top of IEEE 802.15.4 so that Internet and wireless sensor networks can be inter-connected. This interconnection is especially required in commercial and enterprise applications of sensor networks where reliable and timely data transfers such as multiple code updates are needed from Internet nodes to sensor nodes. For this type of inbound traffic which is mostly bulk, TCP as transport layer protocol is essential, resulting in end-to-end TCP session through a default gateway. In this scenario, a single gateway tends to become the bottleneck because of non-uniform connectivity to all the sensor nodes besides being vulnerable to buffer overflow. We propose SET; a management architecture for multiple split-TCP sessions across a number of serving gateways. SET implements striping and multiple TCP session management through a shim at session layer. Through analytical modeling and ns2 simulations, we show that our proposed architecture optimizes communication for ingress bulk data transfer while providing associated load balancing services. We conclude that multiple split-TCP sessions managed in parallel across a number of gateways result in reduced latency for bulk data transfer and provide robustness against gateway failures.
Nagels Durand Astrid
Full Text Available Abstract Background Recombinatorial cloning using the GatewayTM technology has been the method of choice for high-throughput omics projects, resulting in the availability of entire ORFeomes in GatewayTM compatible vectors. The MultiSite GatewayTM system allows combining multiple genetic fragments such as promoter, ORF and epitope tag in one single reaction. To date, this technology has not been accessible in the yeast Saccharomyces cerevisiae, one of the most widely used experimental systems in molecular biology, due to the lack of appropriate destination vectors. Results Here, we present a set of three-fragment MultiSite GatewayTM destination vectors that have been developed for gene expression in S. cerevisiae and that allow the assembly of any promoter, open reading frame, epitope tag arrangement in combination with any of four auxotrophic markers and three distinct replication mechanisms. As an example of its applicability, we used yeast three-hybrid to provide evidence for the assembly of a ternary complex of plant proteins involved in jasmonate signalling and consisting of the JAZ, NINJA and TOPLESS proteins. Conclusion Our vectors make MultiSite GatewayTM cloning accessible in S. cerevisiae and implement a fast and versatile cloning method for the high-throughput functional analysis of (heterologous proteins in one of the most widely used model organisms for molecular biology research.
Bennett, Miles K; Manal, Hana; Van Houten, Ron
Increasing motorists' yielding of the right of way to pedestrians in crosswalks reduces the number of collisions between motorists and pedestrians. In this study we examined a gateway in-street sign configuration (1 in-street sign installed between the 2 travel lanes in each direction, and 1 on both edges of the roadway in each direction) on multilane roads. The first experiment compared the efficacy of adding multiple in-street signs used in a gateway configuration with a single sign between the 2 travel lanes in each direction. The second experiment compared the gateway in-street sign configuration with a more expensive pedestrian hybrid beacon. The third experiment compared the gateway in-street sign configuration with the more expensive rectangular rapid flashing beacon. The results demonstrated that the gateway in-street sign configuration produced very high levels of driver yielding, and that it was as effective as the 2 more expensive treatments. © Society for the Experimental Analysis of Behavior.
Petrakis, Spyros; Raskó, Tamas; Mátés, Lajos; Ivics, Zoltan; Izsvák, Zsuzsanna; Kouzi-Koliakou, Kokkona; Koliakos, George
The Gateway technology cloning system and transposon technology represent state-of-the-art laboratory techniques. Combination of these molecular tools allows rapid cloning of target genes into expression vectors. Here, we describe a novel Gateway technology-compatible transposon plasmid that combines the advantages of Gateway recombination cloning with the Sleeping Beauty (SB) transposon-mediated transgene integrations. In our system the transposition is catalyzed by the novel hyperactive SB100x transposase, and provides highly efficient and precise transgene integrations into the host genome. A Gateway-compatible transposon plasmid was generated in which the potential target gene can be fused with a yellow fluorescent protein (YFP) tag at the N-terminal. The vector utilizes the CAGGS promoter to control fusion protein expression. The transposon expression vector encoding the YFP-interferon-β protein (IFNB1) fusion protein together with the hyperactive SB100x transposase was used to generate stable cell lines in human embryonic kidney (HEK293) and rat adipose-derived stromal cells (ASC). ASCs and HEK293 cells stably expressed and secreted the human IFNB1 for up to 4 weeks after transfection. The generated Gateway-compatible transposon plasmid can be utilized for numerous experimental approaches, such as gene therapy or high-throughput screening methods in primary cells, representing a valuable molecular tool for laboratory applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Hong, Seung Ho; Kim, Se Hwan; Kim, Gi Myung; Kim, Hyung Lae
The SG (smart grid) is a modernized and a future-oriented electric grid that deals with the whole energy chain, from generation to consumer. Among the SG applications, DR (demand response) is an important control mechanism to manage the electricity consumption of the customer in response to supply conditions. In buildings, DR is managed through installed communication networks which support DR applications. BACnet is an international standard communication protocol for building automation and control systems. BACnet uses ZigBee as a wireless communication protocol. Both BACnet and ZigBee have their own DR applications. In this study, we developed a BACnet-ZigBee gateway that maps the DR application of BACnet to that of ZigBee and vice versa. In addition, we developed an experimental facility to demonstrate how the BACnet-ZigBee gateway can be implemented for DR applications in buildings. We also measured the communication delay to verify that the BZ-GW (BACnet-ZigBee smart grid gateway) developed here satisfies the requirements of real-time DR service in buildings. - Highlights: • Developed a gateway that maps the DR application of BACnet to that of ZigBee. • Verified satisfaction for real-time requirement using experimental facility. • The gateway and other device will play a infrastructure role in buildings. • The implementation method could become a reference model for future similar
Benzel, T.; Silva, F.; Deschon, A.; Ye, W.; Cho, Y.
The Satellite Sensornet Gateway (SSG) is an ongoing ESTO Advanced Information Systems Technology project, at the University of Southern California. The major goal of SSG is to develop a turnkey solution for building environmental observation systems based on sensor networks. Our system has been developed through an iterative series of deployment-driven design, build, test, and revise which maximizes technology infusion to the earth scientist. We have designed a robust and flexible sensor network called Sensor Processing and Acquisition Network (SPAN). Our SPAN architecture emphasizes a modular and extensible design, such that core building blocks can be reused to develop different scientific observation systems. To support rapid deployment at remote locations, we employ satellite communications as the backhaul to relay in-situ sensor data to a central database. To easily support various science applications, we have developed a unified sensor integration framework that allows streamlined integration of different sensors to the system. Our system supports heterogeneous sets of sensors, from industry-grade products to research- specific prototypes. To ensure robust operation in harsh environments, we have developed mechanisms to monitor system status and recover from potential failures along with additional remote configuration and QA/QC functions. Here we briefly describe the deployments, the key science missions of the deployments and the role that the SSG technology played in each mission. We first deployed our SSG technology at the James Reserve in February 2007. In a joint deployment with the NEON project, SDSC, and UC Riverside, we set up a meteorological station, using a diverse set of sensors, with the objective of validating our basic technology components in the field. This system is still operational and streaming live sensor data. At Stunt Ranch, a UC Reserve near Malibu, CA, we partnered with UCLA biologist Phillip Rundel in order to study the drought
Koskela, R.; Michener, W. K.; Vieglais, D.; Budden, A. E.
DataONE (Data Observation Network for Earth) is a National Science Foundation DataNet project that enables universal access to data and also facilitates researchers in fulfilling their need for data management and in providing secure and permanent access to their data. DataONE offers the scientific community a suite of tools and training materials that cover all aspects of the data life cycle from data collection, to management, analysis and publication. Data repositories affiliated with DataONE are referred to as Member Nodes and represent large regional, national and international research networks, agencies, and other institutions. As part of the DataONE Federation, the repositories gain access to a range of value-added services to support their users. These services include usage tracking and reporting, content replication, and the ability to register the services created by the repository. In addition, DataONE and the California Digital Library manage ONEShare, a repository that accepts content submitted through Dash, a platform allowing researchers to easily describe, deposit and share their research data.
Soudet, S; Becquart, C; Dezoteux, F; Faure, K; Staumont-Salle, D; Delaporte, E
Bacillus cereus is a ubiquitous telluric organism. B. cereus endocarditis is a rare condition seen mostly in prosthetic heart valves and among intravenous drug users. We report a new case of a patient without risk factors and with a good clinical outcome not requiring valve replacement. In October 2014, a 50-year-old woman was referred to the dermatology department of Lille University Hospital for lower-limb wounds developing 6 months earlier. She presented fever without clinical signs of infection, except for the lower-limbs wounds. Blood cultures revealed the presence of B. cereus. Transesophageal echocardiography was performed and revealed two foci of aortic valve vegetation with a diameter of 5mm. After bacterial sensitivity testing, rifampicin and levofloxacin treatment was given for six weeks, with complete remission. A skin graft was performed and good improvement was seen. Nineteen cases of B. cereus endocarditis have been described previously, only one of which was without risk factors. We described a case of complete remission after a 6-week course of antibiotics. Our case demonstrates that BC should not be considered as a blood culture contamination, and that treatment may be complex due to antibiotic resistance. Copyright © 2016 Elsevier Masson SAS. All rights reserved.
Chiu, Pit Ho Patrio
A Gateway Education Programme is established in Hong Kong that aims to broaden students' interdisciplinary knowledge and nurture student innovations under the Discovery-enriched Curriculum. To support the initiative, a novel idea was proposed for the creation of a Gateway Education Laboratory (GE Lab) with a highly configurable layout equipped…
Groeneveld, Jeroen; Debey, Henry; Hathorne, Ed C.; Steinke, Stephan
We present combined Mg/Ca and δ18O measurements from ODP Site 1241 from the east Pacific and ODP Site 999 from the Caribbean. The studied time interval covers the first major glacial-interglacial cycles (MIS96-101) after intensification of Northern Hemisphere Glaciation. Analyses were performed on the planktic foraminifers Neogloboquadrina dutertrei and Globigerinoides sacculifer, representing water mass properties in the thermocline and the mixed layer respectively. Data resolution is aimed to be able to resolve millennial scale variations to constrain the changes in water mass conditions during MIS96-101. Aim of the study is to test the theory that the Panamanian Gateway temporarily closed during glacial MIS 96, 98, and 100 due to a drop in sea level of 50-80 m. This was first suggested in Groeneveld et al., (in prep.) and might have provided the necessary conditions to allow the Great American Biotic Interchange, the large scale migration of mammals from South to North America and vice versa. As this exchange would have required more arid conditions in Central America to allow the fauna, which was mainly adapted to a savannah-like environment, to cross, a glacial period would have provided the right conditions. Reconstruction of sea water temperatures can indicate if and when the gateway closed. With an open Panamanian Gateway relatively cold water flowed from the Pacific into the Caribbean. With the onset of glacial conditions sea surface temperatures (SST) expectedly would show a decrease in the east Pacific (Site 1241). But, SSTs in the Caribbean (Site 999) are expected to rise as no longer relatively cold Pacific water is entering the Caribbean, but rather the warmer waters from the Western Atlantic Warm Pool advanced from the north to the core location. Indeed, reconstructed SSTs from G. sacculifer show a decrease of 2.5° C at Site 1241 and an increase of 3° C at Site 999 suggesting that the Panamanian Gateway truly was closed during the glacial stage
Zhao, Rong; Rong, Qi-Xian; Liu, Yu-Zhong; Shen, Ye; Huang, Lu-Qi
NAC transcription factors involved in plant growth and development, as well as responses to biotic and abiotic stress. RNAi Vectors for SmNAC transcription factors of Salvia miltiorrhiza was constructed by using Gateway cloning technology, in order to further study the function of SmNAC1 transcription factor. According to Gateway cloning technology, the specific fragments of SmNAC1 containing attB adapter was amplified by PCR using ultra-fideling phusion polymerase of NEB. By the BP recombination reaction, the PCR product containing attB was transferred to an donor vector (pENTR/SD/D-TOPO). Finally, SmNACi specific gene was cloned into pK7GWIWG2D plant expression vectors by LR recombination reaction. Experimental results showed that Gateway cloning technology provide a rapid and highly efficient way to clone the interested gene.
Casarotti, E.; Spinuso, A.; Matser, J.; Leong, S. H.; Magnoni, F.; Krause, A.; Garcia, C. R.; Muraleedharan, V.; Krischer, L.; Anthes, C.
The EU-funded project VERCE (Virtual Earthquake and seismology Research Community in Europe) aims to deploy technologies which satisfy the HPC and data-intensive requirements of modern seismology.As a result of VERCE official collaboration with the EU project SCI-BUS, access to computational resources, like local clusters and international infrastructures (EGI and PRACE), is made homogeneous and integrated within a dedicated science gateway based on the gUSE framework. In this presentation we give a detailed overview on the progress achieved with the developments of the VERCE Science Gateway, according to a use-case driven implementation strategy. More specifically, we show how the computational technologies and data services have been integrated within a tool for Seismic Forward Modelling, whose objective is to offer the possibility to performsimulations of seismic waves as a service to the seismological community.We will introduce the interactive components of the OGC map based web interface and how it supports the user with setting up the simulation. We will go through the selection of input data, which are either fetched from federated seismological web services, adopting community standards, or provided by the users themselves by accessing their own document data store. The HPC scientific codes can be selected from a number of waveform simulators, currently available to the seismological community as batch tools or with limited configuration capabilities in their interactive online versions.The results will be staged out via a secure GridFTP transfer to a VERCE data layer managed by iRODS. The provenance information of the simulation will be automatically cataloged by the data layer via NoSQL techonologies.Finally, we will show the example of how the visualisation output of the gateway could be enhanced by the connection with immersive projection technology at the Virtual Reality and Visualisation Centre of Leibniz Supercomputing Centre (LRZ).
Jelling Kristoffersen, Kåre; Kjærgaard, Mikkel Baun; Chen, Jianjun
Adding content is seen as the next important step in the development and deployment of broadband networks. This paper proposes three different ways of adding content to wireless broadband networks. First, the home gateway is presented as the focal point for delivery of digital services to future...... homes. It must bridge across the most prevalent standard protocols for data, video, telephony and telemetry, and must be able to automatically discover new devices in a residence and allow over the air/wire provisioning, billing, management and aggregation of new services from multiple service providers...
Full Text Available ABSTRAK Penanggulangan permasalahan jaringan yang ada saat ini tidak efektif karena penanggulangan baru akan dilakukan apabila ada laporan dari user bahwa telah terjadi gangguan pada layanan yang digunakannya. Karena pada umumnya seorang admin akan merasa servernya baik-baik saja apabila tidak ada keluhan dari user yang menggunakan layanan servernya. Server SMS gateway dirancang dan direalisasikan agar dapat mengirimkan notifikasi langsung kepada admin tanpa melibatkan user sehingga admin dapat melakukan penanggulangan sebelum user menyampaikan pengaduannya. Nagios digunakan sebagai monitoring server dengan memberikan output notifikasi status pada server. Pengecekan server dilakukan setiap 10 detik. Notifikasi diberikan apabila tidak terjadi perubahan state pada server dalam rentang waktu 180 detik. Gammu sebagai SMS gateway digunakan untuk mengirim notifikasi tersebut kepada admin. Informasi yang diberikan dari nagios kepada gammu diolah menjadi format text untuk dikirimkan melalui layanan SMS sebanyak 160 karakter. Informasi tersebut berisikan IP address dari server yang mengalami gangguan. Notifikasi dikirimkan pada rentang hari dan waktu yang telah ditentukan pada konfigurasi file sistem nagios agar tidak mengganggu kegiatan seorang admin diluar jam kerja . Kata Kunci : Sms, Nagios, Monitoring, Gammu, Notifikasi ABSTRACT Today’s countermeasure of problem network is not effective because it works only when the user reports the problem on the service used. generally an admin think that the server is alright if there is no complain from the user. gateway SMS server is designed and realized in order to send admin a notification directly without involving the user, so that the admin is able to anticipate before he gets complain from the user. Nagois is used to monitoring the server by giving an output notification status on the server. Checking the server is in every ten seconds. A notification will appear when there are no state changes on the
Friedline, Terri; Johnson, Paul; Hughes, Robert
Understanding the balance sheets of today’s young adults—particularly the factors that set them on a path to financial security through asset diversification and accumulation—lends some insight into the balance sheets they will have when they are older. This study uses panel data from the Census Bureau’s 1996 Survey of Income and Program Participation to investigate the acquisition of a savings account as a gateway to asset diversification and accumulation for young adults. Two avenues were c...
Summary of a GATEWAY report evaluation of a tunable LED lighting system installed in the new Swedish Medical Behavioral Health Unit in Seattle that incorporates color-tunable luminaires in common areas, and uses advanced controls for dimming and color tuning, with the goal of providing a better environment for staff and patients. The report reviews the design of the tunable lighting system, summarizes two sets of measurements, and discusses the circadian, energy, and commissioning implications as well as lessons learned from the project.
Yoon, Eun-Jun; Yoo, Kee-Young
This research paper points out that the gateway-oriented password-based authenticated key exchange protocol recently developed by Shim (S-GPAKE) was inefficiently and incorrectly designed to overcome an undetectable on-line password guessing attack. To resolve the computation efficiency and security problems, an optimized GPAKE protocol (O-GPAKE), which was not only secure against various security attacks, but also had considerably lower computational cost and provided mutual authentication unlike previous related protocols including the S-GPAKE protocol was proposed.
Gottschamel, Johanna; Lössl, Andreas
Plastid transformation for the expression of recombinant proteins and entire enzymatic pathways has become a promising tool for plant biotechnology in the past decade. Several improvements of the technology have turned plant plastids into robust and dependable expression platforms for multiple high value compounds. In this chapter, we describe our current methodology based on Gateway(®) recombinant cloning, which we have adapted for plastid transformation. We describe the steps required for cloning, biolistic transformation, identification, and regeneration of transplastomic plant lines and Western blot analysis.
Dempsey, Kathryn M; Ali, Hesham H
High-throughput studies continue to produce volumes of metadata representing valuable sources of information to better guide biological research. With a stronger focus on data generation, analysis models that can readily identify actual signals have not received the same level of attention. This is due in part to high levels of noise and data heterogeneity, along with a lack of sophisticated algorithms for mining useful information. Networks have emerged as a powerful tool for modeling high-throughput data because they are capable of representing not only individual biological elements but also different types of relationships en masse. Moreover, well-established graph theoretic methodology can be applied to network models to increase efficiency and speed of analysis. In this project, we propose a network model that examines temporal data from mouse hippocampus at the transcriptional level via correlation of gene expression. Using this model, we formally define the concept of "gateway" nodes, loosely defined as nodes representing genes co-expressed in multiple states. We show that the proposed network model allows us to identify target genes implicated in hippocampal aging-related processes. By mining gateway genes related to hippocampal aging from networks made from gene expression in young and middle-aged mice, we provide a proof-of-concept of existence and importance of gateway nodes. Additionally, these results highlight how network analysis can act as a supplement to traditional statistical analysis of differentially expressed genes. Finally, we use the gateway nodes identified by our method as well as functional databases and literature to propose new targets for study of aging in the mouse hippocampus. This research highlights the need for methods of temporal comparison using network models and provides a systems biology approach to extract information from correlation networks of gene expression. Our results identify a number of genes previously implicated
Buj, Raquel; Iglesias, Noa; Planas, Anna M; Santalucía, Tomàs
Valuable clone collections encoding the complete ORFeomes for some model organisms have been constructed following the completion of their genome sequencing projects. These libraries are based on Gateway cloning technology, which facilitates the study of protein function by simplifying the subcloning of open reading frames (ORF) into any suitable destination vector. The expression of proteins of interest as fusions with functional modules is a frequent approach in their initial functional characterization. A limited number of Gateway destination expression vectors allow the construction of fusion proteins from ORFeome-derived sequences, but they are restricted to the possibilities offered by their inbuilt functional modules and their pre-defined model organism-specificity. Thus, the availability of cloning systems that overcome these limitations would be highly advantageous. We present a versatile cloning toolkit for constructing fully-customizable three-part fusion proteins based on the MultiSite Gateway cloning system. The fusion protein components are encoded in the three plasmids integral to the kit. These can recombine with any purposely-engineered destination vector that uses a heterologous promoter external to the Gateway cassette, leading to the in-frame cloning of an ORF of interest flanked by two functional modules. In contrast to previous systems, a third part becomes available for peptide-encoding as it no longer needs to contain a promoter, resulting in an increased number of possible fusion combinations. We have constructed the kit's component plasmids and demonstrate its functionality by providing proof-of-principle data on the expression of prototype fluorescent fusions in transiently-transfected cells. We have developed a toolkit for creating fusion proteins with customized N- and C-term modules from Gateway entry clones encoding ORFs of interest. Importantly, our method allows entry clones obtained from ORFeome collections to be used without prior
West, Joshua H; Blumberg, Elaine J; Kelley, Norma J; Hill, Linda; Sipan, Carol L; Schmitz, Katherine; Kolody, Bohdan; Madlensky, Lisa; Hovell, Melbourne F
Parent and adolescent self-reports are the most common sources for measuring parenting practices. This study's purpose was to compare how parent and adolescent reports of parenting behaviors differentially predict adolescent gateway drug use. The sample consisted of 252 Latino adolescent-parent dyads. After controlling for potential confounding influences, only adolescents' reports about their parents' parenting behaviors were significant and explained 38% of the variance in gateway drug use. Practitioners may recommend to parents seeking parenting advice that they solicit feedback from their adolescent to ensure parenting efforts are received in the manner they were intended.
WEST, JOSHUA H.; BLUMBERG, ELAINE J.; KELLEY, NORMA J.; HILL, LINDA; SIPAN, CAROL L.; SCHMITZ, KATHERINE; KOLODY, BOHDAN; MADLENSKY, LISA; HOVELL, MELBOURNE F.
Parent and adolescent self-reports are the most common sources for measuring parenting practices. This study’s purpose was to compare how parent and adolescent reports of parenting behaviors differentially predict adolescent gateway drug use. The sample consisted of 252 Latino adolescent-parent dyads. After controlling for potential confounding influences, only adolescents’ reports about their parents’ parenting behaviors were significant and explained 38% of the variance in gateway drug use. Practitioners may recommend to parents seeking parenting advice that they solicit feedback from their adolescent to ensure parenting efforts are received in the manner they were intended. PMID:21409705
Hu, Q.; Winjum, B. J.; Zonca, A.; Youn, C.; Tsung, F. S.; Mori, W. B.
Computer simulations offer tremendous opportunities for studying plasmas, ranging from simulations for students that illuminate fundamental educational concepts to research-level simulations that advance scientific knowledge. Nevertheless, there is a significant hurdle to using simulation tools. Users must navigate codes and software libraries, determine how to wrangle output into meaningful plots, and oftentimes confront a significant cyberinfrastructure with powerful computational resources. Science gateways offer a Web-based environment to run simulations without needing to learn or manage the underlying software and computing cyberinfrastructure. We discuss our progress on creating a Science Gateway for the Particle-in-Cell and Kinetic Simulation Software Center that enables users to easily run and analyze kinetic simulations with our software. We envision that this technology could benefit a wide range of plasma physicists, both in the use of our simulation tools as well as in its adaptation for running other plasma simulation software. Supported by NSF under Grant ACI-1339893 and by the UCLA Institute for Digital Research and Education.
Fan, Kuo-Pao; Chang, Shu-Hsin; Lin, Kuan-Ming; Pen, Mau-Jy
IP-based Virtual Private Network becomes more and more popular. It can not only reduce the enterprise communication cost but also increase the revenue of the service provider. The common IP-VPN application types include Intranet VPN, Extranet VPN, and remote access VPN. For the large IP-VPN market, some vendors develop dedicated IP-VPN devices; while some vendors add the VPN functions into their existing network equipment such as router, access gateway, etc. The functions in the IP-VPN device include security, QoS, and management. The common security functions supported are IPSec (IP Security), IKE (Internet Key Exchange), and Firewall. The QoS functions include bandwidth control and packet scheduling. In the management component, policy-based network management is under standardization in IETF. In this paper, we discuss issues on how to integrate the QoS and security functions in an IP-VPN Gateway. We propose three approaches to do this. They are (1) perform Qos first (2) perform IPSec first and (3) reserve fixed bandwidth for IPSec. We also compare the advantages and disadvantages of the three proposed approaches.
Pakistan has an extensive public sector service delivery infrastructure consisting of a three tiered healthcare delivery system which includes Basic Health Units and Rural Health Centers forming the core of the primary health model, secondary care including first and second referral facilities providing acute, ambulatory and inpatient care through Tehsil Headquarter and District Headquarter hospitals and Tertiary Care comprising teaching hospitals. Notwithstanding, most people receive healthcare through private out-of-pocket payments made directly to the providers at the point of care. Recently, many attempts have been made to mainstream alternative arrangements of service delivery at various levels in order to bridge gaps in the present system of service delivery, albeit with limited success. As one of the core areas of reform-related interventions, the Gateway Paper makes a strong case for introducing change at two levels in order to obviate these issues. Firstly, at the level of hospitals the hospital sustainability reform process calls for major structural and financing adjustments, the development of appropriate policy frameworks, decentralizing hospital management to autonomous hospital boards and providing legal, managerial and fiscal autonomy to hospitals with appropriate community representation. At the primary healthcare level, a system for restructuring BHUs and RHCs has been supported--one that makes a case for appropriate checks and balances in order to ensure sustained improvements by redefining the roles of management, quality assurance, regulation and community oversight the latter through linkages with the devolution initiative. The Gateway Paper dovetails these alternative service delivery arrangements with parallel financing models.
Bergman, Richard N; Iyer, Malini S
On the basis of studies that investigated the intraportal versus systemic insulin infusion and transendothelial transport of insulin, we proposed the "single gateway hypothesis," which supposes an indirect regulation of hepatic glucose production by insulin; the rate-limiting transport of insulin across the adipose tissue capillaries is responsible for the slow suppression of free fatty acids (FFAs), which in turn is responsible for delayed suppression of hepatic endogenous glucose production (EGP) during insulin infusion. Preventing the fall in plasma FFAs during insulin infusion either by administering intralipids or by inhibiting adipose tissue lipolysis led to failure in EGP suppression, thus supporting our hypothesis. More recently, mice lacking hepatic Foxo1 in addition to Akt1 and Akt2 (L-AktFoxo1TKO), all required for insulin signaling, surprisingly showed normal glycemia. Inhibiting the fall of plasma FFAs in these mice prevented the suppression of EGP during a clamp, reaffirming that the site of insulin action to control EGP is extrahepatic. Measuring whole-body turnover rates of glucose and FFAs in L-AktFoxo1TKO mice also confirmed that hepatic EGP was regulated by insulin-mediated control of FFAs. The knockout mouse model in combination with sophisticated molecular techniques confirmed our physiological findings and the single gateway hypothesis. © 2017 by the American Diabetes Association.
Miller, Mark A; Schwartz, Terri; Pickett, Brett E; He, Sherry; Klem, Edward B; Scheuermann, Richard H; Passarotti, Maria; Kaufman, Seth; O'Leary, Maureen A
The CIPRES Science Gateway is a community web application that provides public access to a set of parallel tree inference and multiple sequence alignment codes run on large computational resources. These resources are made available at no charge to users by the NSF Extreme Science and Engineering Discovery Environment (XSEDE) project. Here we describe the CIPRES RESTful application programmer interface (CRA), a web service that provides programmatic access to all resources and services currently offered by the CIPRES Science Gateway. Software developers can use the CRA to extend their web or desktop applications to include the ability to run MrBayes, BEAST, RAxML, MAFFT, and other computationally intensive algorithms on XSEDE. The CRA also makes it possible for individuals with modest scripting skills to access the same tools from the command line using curl, or through any scripting language. This report describes the CRA and its use in three web applications (Influenza Research Database - www.fludb.org, Virus Pathogen Resource - www.viprbrc.org, and MorphoBank - www.morphobank.org). The CRA is freely accessible to registered users at https://cipresrest.sdsc.edu/cipresrest/v1; supporting documentation and registration tools are available at https://www.phylo.org/restusers.
Wille, Thorsten; Barlag, Britta; Jakovljevic, Vladimir; Hensel, Michael; Sourjik, Victor; Gerlach, Roman G.
Protein-protein interactions are important layers of regulation in all kingdoms of life. Identification and characterization of these interactions is one challenging task of the post-genomic era and crucial for understanding of molecular processes within a cell. Several methods have been successfully employed during the past decades to identify protein-protein interactions in bacteria, but most of them include tedious and time-consuming manipulations of DNA. In contrast, the MultiSite Gateway system is a fast tool for transfer of multiple DNA fragments between plasmids enabling simultaneous and site directed cloning of up to four fragments into one construct. Here we developed a new set of Gateway vectors including custom made entry vectors and modular Destination vectors for studying protein-protein interactions via Fluorescence Resonance Energy Transfer (FRET), Bacterial two Hybrid (B2H) and split Gaussia luciferase (Gluc), as well as for fusions with SNAP-tag and HaloTag for dual-color super-resolution microscopy. As proof of principle, we characterized the interaction between the Salmonella effector SipA and its chaperone InvB via split Gluc and B2H approach. The suitability for FRET analysis as well as functionality of fusions with SNAP- and HaloTag could be demonstrated by studying the transient interaction between chemotaxis response regulator CheY and its phosphatase CheZ. PMID:25856398
Villefranc, Jacques A.; Amigo, Julio; Lawson, Nathan D.
The recent establishment of recombination-based cloning systems has greatly facilitated the analysis of gene function by allowing rapid and high-efficiency generation of plasmid constructs. However, the use of such an approach in zebrafish requires the availability of recombination-compatible plasmids that are appropriate for functional studies in zebrafish embryos. In this work, we describe the construction and validation of Gateway compatible vectors based on commonly used zebrafish plasmids. We have generated pCS-based plasmids that allow rapid generation of both N-terminal and C-terminal fusion proteins, and we demonstrate that mRNA synthesized from these plasmids encodes functional native or fusion proteins in injected zebrafish embryos. In parallel, we have established similar Gateway plasmids containing Tol2 cis elements that promote efficient integration into the zebrafish genome and allow expression of native or fusion proteins in a tissue-specific manner in the zebrafish embryo. Finally, we demonstrate the use of this system to rapidly identify tissue-specific cis elements to aid the establishment of blood vessel-specific transgenic constructs. Taken together, this work provides an important platform for the rapid functional analyses of open reading frames in zebrafish embryos. PMID:17948311
Background Error-prone PCR (epPCR) libraries are one of the tools used in directed evolution. The Gateway® technology allows constructing epPCR libraries virtually devoid of any background (i.e., of insert-free plasmid), but requires two steps: the BP and the LR reactions and the associated E. coli cell transformations and plasmid purifications. Results We describe a method for making epPCR libraries in Gateway® plasmids using an LR reaction without intermediate BP reaction. We also describe a BP-free and LR-free sub-cloning method for in-frame transferring the coding sequence of selected clones from the plasmid used to screen the library to another one devoid of tag used for screening (such as the green fluorescent protein). We report preliminary results of a directed evolution program using this method. Conclusions The one-step method enables producing epPCR libraries of as high complexity and quality as does the regular, two-step, protocol for half the amount of work. In addition, it contributes to preserve the original complexity of the epPCR product. PMID:22289297
Full Text Available Introduction. Specialised subject gateways have become an essential tool for locating and accessing digital information resources, with the added value of organisation and previous evaluation catering for the needs of the varying communities using these. Within the framework of a research project on the subject, a software tool has been developed that enables subject gateways to be developed and managed. Method. General guidelines for the work were established which set out the main principles for the technical aspects of the application, on one hand, and on aspects of the treatment and management of information, on the other. All this has been integrated into a prototype model for developing software tools. Analysis. The needs analysis established the conditions to be fulfilled by the application. A detailed study of the available options for the treatment of information on metadata proved that the best option was to use the Dublin Core, and that the metadata set should be included, in turn, in RDF tags, or in tags based on XML. Results. The project has resulted in the development of two versions of an application called Potnia (versions 1 and 2, which fulfil the requirements set out in the main principles, and which have been tested by users in real application environments. Conclusion. The tagging layout found to be the best, and the one used by the writers, is based on integrating the Dublin Core metadata set within the Topic Maps paradigm, formatted in XTM.
Full Text Available The objective of this paper is to explore more realistic and sustainable territorial and logistics strategies (see Fabbro, Mesolella, 2010 in order to reconnect the Italian infrastructural system to the wider network of European corridors.Until this moment, the logistics and strategic national plans have not been selective concerning the identification, along the TEN-T Corridors, of a few ports and freight villages which are able to become effective European gateways within the Italian territory and attract private investments. Moreover, these planning instruments, instead of basing their strategies on the most concrete corridors have preferred to conceive their policies on entirely “imaginary” ones. This is, for instance, the case of the Logistics Platform in the Nord-East area of Italy. This Platform has been organized around the uncertain Corridor V, rather than the more concrete (but not yet recognized in the European maps Adriatic-Baltic corridor. As a consequence, in this Region, several existing national infrastructures appear, at the moment, largely underused: a freight village of considerable size and European standards such as the Interporto Alpe Adria in Cervignano del Friuli, and an international double railway such as the “Pontebbana” that links the North-East area of Italy with Austria, through the Alpine pass of Tarvisio, and which is already the southern segment of the Adriatic-Baltic corridor. On the other hand, these infrastructures might play a significant role in light of the positive estimates about the new trends of maritime trades, which would realize a renewed centrality to the Mediterranean Sea (Drewry Shipping Consultants, 2010, and important development programs regarding the Adriatic ports, involving both public (Venice, Rijeka and private (Monfalcone-Triest, Koper stakeholders. The aim of these projects is to increase the competitive capacity of the North Adriatic port system and establish a more effective
von der Heydt, Anna; Viebahn, Jan; Dijkstra, Henk
During the Cenozoic period, which covers the last 65 Million (Ma) years, Earth's climate has undergone a major long-term transition from warm "greenhouse" to colder "icehouse" conditions with extensive ice sheets in the polar regions of both hemispheres. On the very long term the gradual cooling may be seen as response to the overall slowly decreasing atmospheric CO2-concentration due to weathering processes in the Earth System, however, continental geometry has changed considerably over this period and the long-term gradual trend was interrupted, by several rapid transitions as well as periods where temperature and greenhouse gas concentrations seem to be decoupled. The Eocene-Oligocene boundary (˜34 Ma, E/O) and mid-Miocene climatic transition (˜13 Ma, MCT) reflect major phases of Antarctic ice sheet build-up and global climate cooling, while Northern Hemisphere ice sheets developed much later, most likely at the Pliocene-Pleistocene transition (˜2.7Ma). Thresholds in atmospheric CO2-concentration together with feedback mechanisms related to land ice formation are now among the favoured mechanisms of these climatic transitions, while the long-proposed ocean circulation changes caused by opening of tectonic gateways seem to play a less direct role. The opening of the Southern Ocean gateways, notably the Drake Passage and the Tasman Gateway as well as the northward movement of Australia over this long time period, however, has eventually led to the development of today's strongest ocean current, the Antarctic Circumpolar Current (ACC), playing a major role in the transport properties of the global ocean circulation. The overall state of the global ocean circulation, therefore, preconditions the climate system to dramatic events such as major ice sheet formation. Here, we present results of a state-of-the art global climate model (CESM) under various continental configurations: (i) present day geometry, (ii) present day geometry with a closed Drake Passage and
Full Text Available Abstract Background Cloning genes into plasmid vectors is one of the key steps for studying gene function. Recently, Invitrogen™ developed a convenient Gateway® cloning system based on the site-specific DNA recombination properties of bacteriophage lambda and the cytotoxic protein ccdB, which is lethal to most E. coli strains. The ccdB protein, however, is not toxic to Agrobacterium tumefaciens, an important player often used for studying gene function in planta. This limits the direct application of the Gateway® cloning system in plant transformation-mediated research. Results In this study, we constructed a novel Gateway®-compatible destination vector, pEG101-SacB/R, by replacing the ccdB gene with a SacB-SacR gene cassette as the negative selectable marker. Conclusion Our results demonstrate that the new pEG101-SacB/R destination vector can be used for Gateway® cloning in Agrobacterium tumefaciens. pEG101-SacB/R will be a valuable tool for high-throughput functional analysis of genes in planta.
Galluzzi, M. C.
Three goals can be achieved by 2030: 1. NASA will have the capability for remote on-demand 3d printing of critical hardware using regolith material as feedstock, 2. Logistics footprint reduced by 35%, 3. Deep Space Gateway will become 75% self-sustaining.
Huang, Yan-You; Lavine, Amir; Kandel, Denise B.; Yin, Deqi; Colnaghi, Luca; Drisaldi, Bettina; Kandel, Eric R.
The dentate gyrus (DG) of the hippocampus is critical for spatial memory and is also thought to be involved in the formation of drug-related associative memory. Here, we attempt to test an aspect of the Gateway Hypothesis, by studying the effect of consecutive exposure to nicotine and cocaine on long-term synaptic potentiation (LTP) in the DG. We…
Opoku-Amankwa, Kwasi; Brew-Hammond, Aba; Kofigah, Francis Elsbend
This paper investigates three English textbooks for primary classes 4, 5 and 6 in Ghana from the "Gateway to English for Primary Schools" series, and their complementary teachers' guides, in order to determine the assumptions about teaching and learning which the books embody. The paper pays particular attention to the approach to…
Monthly follow-up data confirmed that permanent in roadway installations of the R1-6 gateway treatment led to an : increase in the percentage of drivers yielding to pedestrians at midblock and multilane urban and suburban locations : from 15% to 70% ...
Traore, Sy Mamadou; Zhao, Bingyu
Cloning genes into plasmid vectors is one of the key steps for studying gene function. Recently, Invitrogen™ developed a convenient Gateway® cloning system based on the site-specific DNA recombination properties of bacteriophage lambda and the cytotoxic protein ccdB, which is lethal to most E. coli strains. The ccdB protein, however, is not toxic to Agrobacterium tumefaciens, an important player often used for studying gene function in planta. This limits the direct application of the Gateway® cloning system in plant transformation-mediated research. In this study, we constructed a novel Gateway®-compatible destination vector, pEG101-SacB/R, by replacing the ccdB gene with a SacB-SacR gene cassette as the negative selectable marker. Our results demonstrate that the new pEG101-SacB/R destination vector can be used for Gateway® cloning in Agrobacterium tumefaciens. pEG101-SacB/R will be a valuable tool for high-throughput functional analysis of genes in planta.
Nkansah-Amankra, Stephen; Minelli, Mark
To evaluate the consistency of the relationship between early drug use in adolescence and illegal drug use in adulthood as proposed in the "gateway theory" and to determine whether pre-existing depressive symptoms modifies this relationship. We used contractual data from the National Longitudinal Study of Adolescent to Adult health data spanning a 14 year period. We assessed the relationship between gateway drugs at baseline (age 11-20 years) and drug use in adulthood using generalized estimating equation (GEE) regression models. Gateways drugs used in early adolescence were significantly associated with marijuana use, illegal drugs and cocaine in older adolescence, but over time these relationships were not consistent in adulthood. Changes in the pattern of psychoactive drug use were important predictors of drug use in adulthood. A history of higher depressive symptoms was associated with higher frequencies of psychoactive drug use over time. Users of mental health services in adolescence were less likely to use drugs in older adolescence and in adulthood. Relationships between early drug use and later drug use in adulthood cannot be solely explained by the gateway hypothesis. Collectively, adolescent drug prevention and treatment programs should apply theory-based and evidence-proven multisectoral intervention strategies rather than providing a brief counseling on individual's behaviors. This evidence should include understanding that changes in behavior should involve broader analyses of the underlying social context for drug use and in particular the role of the community social norms in driving a group's behaviors.
Summary of GATEWAY report evaluating a new lighting system, at the offices of the accounting firm of DeJoy, Knauf & Blood, LLP in Rochester, NY, that incorporates a number of different OLED luminaires. Evaluation of the OLED products included efficacy performance, field measurements of panel color, flicker measurements, and staff feedback.
Spinuso, Alessandro; Krause, Amy; Ramos Garcia, Clàudia; Casarotti, Emanuele; Magnoni, Federica; Klampanos, Iraklis A.; Frobert, Laurent; Krischer, Lion; Trani, Luca; David, Mario; Leong, Siew Hoon; Muraleedharan, Visakh
The EU-funded project VERCE (Virtual Earthquake and seismology Research Community in Europe) aims to deploy technologies which satisfy the HPC and data-intensive requirements of modern seismology. As a result of VERCE's official collaboration with the EU project SCI-BUS, access to computational resources, like local clusters and international infrastructures (EGI and PRACE), is made homogeneous and integrated within a dedicated science gateway based on the gUSE framework. In this presentation we give a detailed overview on the progress achieved with the developments of the VERCE Science Gateway, according to a use-case driven implementation strategy. More specifically, we show how the computational technologies and data services have been integrated within a tool for Seismic Forward Modelling, whose objective is to offer the possibility to perform simulations of seismic waves as a service to the seismological community. We will introduce the interactive components of the OGC map based web interface and how it supports the user with setting up the simulation. We will go through the selection of input data, which are either fetched from federated seismological web services, adopting community standards, or provided by the users themselves by accessing their own document data store. The HPC scientific codes can be selected from a number of waveform simulators, currently available to the seismological community as batch tools or with limited configuration capabilities in their interactive online versions. The results will be staged out from the HPC via a secure GridFTP transfer to a VERCE data layer managed by iRODS. The provenance information of the simulation will be automatically cataloged by the data layer via NoSQL techonologies. We will try to demonstrate how data access, validation and visualisation can be supported by a general purpose provenance framework which, besides common provenance concepts imported from the OPM and the W3C-PROV initiatives, also offers
Geissler, Wolfram; Knies, Jochen
The modern polar cryosphere reflects an extreme climate state with profound temperature gradients towards high-latitudes. It developed in association with stepwise Cenozoic cooling, beginning with ephemeral glaciations and the appearance of sea ice in the late middle Eocene. The polar ocean gateways played a pivotal role in changing the polar and global climate, along with declining greenhouse gas levels. The opening of the Drake Passage finalized the oceanographic isolation of Antarctica, some 40 Ma ago. The Arctic Ocean was an isolated basin until the early Miocene when rifting and subsequent sea-floor spreading started between Greenland and Svalbard, initiating the opening of the Fram Strait / Arctic-Atlantic Gateway (AAG). Although this gateway is known to be important in Earth's past and modern climate, little is known about its Cenozoic development. However, the opening history and AAG's consecutive widening and deepening must have had a strong impact on circulation and water mass exchange between the Arctic Ocean and the North Atlantic. To study the AAG's complete history, ocean drilling at two primary sites and one alternate site located between 73°N and 78°N in the Boreas Basin and along the East Greenland continental margin are proposed. These sites will provide unprecedented sedimentary records that will unveil (1) the history of shallow-water exchange between the Arctic Ocean and the North Atlantic, and (2) the development of the AAG to a deep-water connection and its influence on the global climate system. The specific overarching goals of our proposal are to study: (1) the influence of distinct tectonic events in the development of the AAG and the formation of deep water passage on the North Atlantic and Arctic paleoceanography, and (2) the role of the AAG in the climate transition from the Paleogene greenhouse to the Neogene icehouse for the long-term (~50 Ma) climate history of the northern North Atlantic. Getting a continuous record of the
Pakistan currently principally uses three modes of financing health--taxation, out of pocket payments and donor contributions of which the latter is the least significant in terms of size. Less than 3.6% of the employees are covered under the social security scheme and there is a limited social protection mechanism, which collectively serves the health needs of 3.4% of the population. The main issues in health financing include low spending, lack of attention to alternate sources of financing and issues with fund mobilization and utilization. With respect to the first, health reforms proposed as part of the Gateway Paper make a strong case for promoting the reallocation of tax-based revenues and developing sustainable alternatives to low levels of public spending on health. With respect to alternative sources of health financing, the Gateway Paper lays stress on exploring policy options for private health insurance, broadening the base of Employees Social Security, creating a Federal Employees Social Security Programme, developing social health insurance within the framework of a broad-based social protection strategy, which scopes beyond the formally employed sector, establishing a widely inclusive safety net for the poor; mainstreaming philanthropic grants as a major source of health financing; developing a conducive tax configuration; generating greater corporate support for social sector causes within the framework of the concept of Corporate Social Responsibility and developing cost-sharing programmes, albeit with safeguards. The Gateway Paper regards efficient fund utilization a priority and lays stress on striking a balance between minimizing costs, controlling costs and using resources more efficiently and equitably--in other words, getting the best value for the money, on the one hand, and increasing the pool of available resources, on the other. Specific interventions such as the promotion of transparent financial administration, budgeting and cost
Full Text Available Message Queuing Telemetry Transport for Sensor Networks (MQTT-SN and Constrained Application Protocol (CoAP are two protocols supporting publish/subscribe models for IoT devices to publish messages to interested subscribers. Retransmission mechanisms are introduced to compensate for the lack of data reliability. If the device does not receive the acknowledgement (ACK before retransmission timeout (RTO expires, the device will retransmit data. Setting an appropriate RTO is important because the delay may be large or retransmission may be too frequent when the RTO is inappropriate. We propose a Gateway-assisted CoAP (GaCoAP to dynamically compute RTO for devices. Simulation models are proposed to investigate the performance of GaCoAP compared with four other methods. The experiment results show that GaCoAP is more suitable for IoT devices.
Deng, Hongyu; Wu, Cheng; Wang, Yiming
A key technique of LTE is how to allocate efficiently the resource of radio spectrum. Traditional Round Robin (RR) scheduling scheme may lead to too many resource residues when allocating resources. When the number of users in the current transmission time interval (TTI) is not the greatest common divisor of resource block groups (RBGs), and such a phenomenon lasts for a long time, the spectrum utilization would be greatly decreased. In this paper, a novel spectrum allocation scheme of cognitive gateway (CG) was proposed, in which the LTE spectrum utilization and CG’s throughput were greatly increased by allocating idle resource blocks in the shared TTI in LTE system to CG. Our simulation results show that the spectrum resource sharing method can improve LTE spectral utilization and increase the CG’s throughput as well as network use time.
Full Text Available Penelitian ini bertujuan untuk mempermudah penanganan ketidakdisiplinan siswa dalam lingkungan sekolah dengan membangun aplikasi yang mempermudah perhitungan point pelanggaran tata tertib siswa sehingga pihak sekolah dapat melakukan tindakan dan kebijakan-kebijakan yang berkaitan dengan peningkatan kepribadian siswa serta dengan di integrasikannya aplikasi dengan sms gateway yang secara otomatis mengirimkan laporan tentang ketidakdisiplinan siswa langsung kepada wali murid. Data poin pelanggaran siswa di ambil dari SMK YPT 1 Purbalingga. Jumlah point kesalahan yang dihitung kemudian ditindak lanjuti dalam berbagai tingkatan, mulai dari peringatan, panggilan disertai membuat surat perjanjian, sampai pada tingkat yang paling tinggi dengan bobot /jumlah point kesalahan paling besar dikembalikan kepada wali murid. Metode pengembangan sistem yang digunakan adalah metode waterfall. Perancangan sistem menggunakan Data Flow Diagram (DFD, implementasi program menggunakan bahasa Visual Studio 2012 dan database MySQL dan pengujian dilakukan menggunakan metode black-box yang hasilnya fungsional sistem bekerja menghasilkan output yang diharapkan.
Full Text Available Routing protocol to the wireless ad hoc networks is very needed in the communication process between some terminals, to send the data packet through one or several node(s to the destination address where the network typology is always changing. Many previous works that discussed about routing ad hoc both for manet (mobile ad hoc networks and wireless networks, but the emphasis have more focus on comparing the performance of several routing ad hoc. While in this work, there is a bulding of routing algorithm model to gateway in land to the nodes that analogized as a boat that move on the sea. With the assumption that the communication inter terminals to radio band of Very High Frequency, thus algorithm that built in the simulation based on the range gap of the HF frequency. The result of this simulation will be developed as the platform to implement the service development of multiuser communication
Mahmood, Z; Hashim, A; Khalifa, O; Anwar, F; Hameed, S
The fast growth of Internet applications brings with it new challenges for researchers to provide new solutions that guarantee better Internet access for mobile hosts and networks. The globally reachable, Home-Agent based, infrastructure Network Mobility (NEMO) and the local, multi-hop, and infrastructure-less Mobile Ad hoc Network (MANET) developed by Internet Engineering Task Force (IETF) support different topologies of the mobile networks. A new architecture was proposed by combining both topologies to obtain Mobile Ad Hoc NEMO (MANEMO). However, the integration of NEMO and MANET introduces many challenges such as network loops, sub-optimal route, redundant tunnel problem, absence of communication without Home Agent reachability, and exit router selection when multiple Exit Routers to the Internet exist. This paper aims to review the different proposed models that could be used to implement the gateway selection mechanism and it highlights the strengths as well as the limitations of these approaches
Full Text Available Audio mastering, notwithstanding an apparent lack of scholarly attention, is a crucial gateway between production and consumption and, as such, is worth further scrutiny, especially in music genres like house or techno, which place great emphasis on sound production qualities. In this article, drawing on personal interviews with mastering engineers and field research in mastering studios in Italy and Germany, I investigate the practice of mastering engineering, paying close attention to the negotiation of techniques and sound aesthetics in relation to changes in the industry formats and, in particular, to the growing shift among DJs from vinyl to compressed digital formats. I then discuss the specificity of audio mastering in relation to EDM, insofar as DJs and controllerists conceive of the master, rather than as a finished product destined to listening, as raw material that can be reworked in performance.
Townsend, Sarah Sm; Truong, Mindy
Attaining a college degree has traditionally been assumed to be key to upward social and professional mobility. However, college graduates from working-class backgrounds achieve less career success in professional, white-collar workplaces compared to those from middle-class backgrounds. Using a cultural models approach, we examine how the independent cultural beliefs and practices promoted by professional organizations disadvantage people from working-class backgrounds, who espouse interdependent beliefs and practices. Our review illustrates how this disadvantage can manifest in two ways. First, despite relative equality in objective qualifications, it can occur at organizational gateways (e.g., interview and hiring decisions). Second, even after people from working-class backgrounds gain access to an organization, it can occur along organizational pathways (e.g., performance evaluations and assignment to high-profile tasks). Copyright © 2017. Published by Elsevier Ltd.
Chang, Hui-Ling; Wang, Cheng-Gang; Wu, Mong-Ting; Tsai, Meng-Hsun; Lin, Chia-Ying
Message Queuing Telemetry Transport for Sensor Networks (MQTT-SN) and Constrained Application Protocol (CoAP) are two protocols supporting publish/subscribe models for IoT devices to publish messages to interested subscribers. Retransmission mechanisms are introduced to compensate for the lack of data reliability. If the device does not receive the acknowledgement (ACK) before retransmission timeout (RTO) expires, the device will retransmit data. Setting an appropriate RTO is important because the delay may be large or retransmission may be too frequent when the RTO is inappropriate. We propose a Gateway-assisted CoAP (GaCoAP) to dynamically compute RTO for devices. Simulation models are proposed to investigate the performance of GaCoAP compared with four other methods. The experiment results show that GaCoAP is more suitable for IoT devices.
Hernandez, Elaine M; Margolis, Rachel; Hummer, Robert A
Hypertension represents a gateway diagnosis to more serious health problems that occur as people age. We examine educational differences in three health behavior changes people often make after receiving this diagnosis in middle or older age, and test whether these educational differences depend on (a) the complexity of the health behavior change and (b) gender. We use data from the Health and Retirement Study and conduct logistic regression analysis to examine the likelihood of modifying health behaviors post diagnosis. We find educational differences in three behavior changes-antihypertensive medication use, smoking cessation, and physical activity initiation-after a hypertension diagnosis. These educational differences in health behaviors were stronger among women compared with men. Upon receiving a hypertension diagnosis, education is a more important predictor of behavior changes for women compared with men, which may help explain gender differences in the socioeconomic gradient in health in the United States.
Mehrabi, Rahim; Mirzadi Gohari, Amir; da Silva, Gilvan Ferreira; Steinberg, Gero; Kema, Gert H J; de Wit, Pierre J G M
Genetic manipulation of fungi requires quick, low-cost, efficient, high-throughput and molecular tools. In this paper, we report 22 entry constructs as new molecular tools based on the Gateway technology facilitating rapid construction of binary vectors that can be used for functional analysis of genes in fungi. The entry vectors for single, double or triple gene-deletion mutants were developed using hygromycin, geneticin and nourseothricin resistance genes as selection markers. Furthermore, entry vectors containing green fluorescent (GFP) or red fluorescent (RFP) in combination with hygromycin, geneticin or nourseothricin selection markers were generated. The latter vectors provide the possibility of gene deletion and simultaneous labelling of the fungal transformants with GFP or RFP reporter genes. The applicability of a number of entry vectors was validated in Zymoseptoria tritici, an important fungal wheat pathogen. Copyright © 2015 Elsevier Inc. All rights reserved.
Fries, M.; Fisher, K.
The Deep Space Gateway (DSG) may provide a platform for direct sampling of a large number of comets and asteroids, through employment of an instrument for characterizing dust from these bodies. Every year, the Earth traverses through debris streams of dust and small particles from comets and asteroids in Earth-crossing orbits, generating short-lived outbursts of meteor activity commonly known as "meteor showers" (Figure 1). The material in each debris stream originates from a distinct parent body, many of which have been identified. By sampling this material, it is possible to quantitatively analyze the composition of a dozen or more comets and asteroids (See Figure 2, following page) without leaving cislunar space.
Nakamura, Shinya; Mano, Shoji; Tanaka, Yuji; Ohnishi, Masato; Nakamori, Chihiro; Araki, Masami; Niwa, Tomoko; Nishimura, Mikio; Kaminaka, Hironori; Nakagawa, Tsuyoshi; Sato, Yutaka; Ishiguro, Sumie
We constructed two series of Gateway binary vectors, pGWBs and R4pGWBs, possessing the bialaphos resistance gene (bar) as a selection marker for plant transformation. The reporters and tags employed in this system are sGFP, GUS, LUC, EYFP, ECFP, G3GFP, mRFP, TagRFP, 6xHis, FLAG, 3xHA, 4xMyc, 10xMyc, GST, T7 and TAP. Selection of Arabidopsis transformants with BASTA was successfully carried out using both plate-grown and soil-grown seedlings. Transformed rice calli and suspension-cultured tobacco cells were selected on plates containing BASTA or glufosinate-ammonium. These vectors are compatible with existing pGWB and R4pGWB vectors carrying kanamycin and hygromycin B resistance.
Etxaniz, J; Monje, P M; Aranguren, G
This Note introduces a novel methodology to analyze the time performance of Bluetooth gateways in multi-hop networks, known as scatternets. The methodology is focused on distinguishing between the processing time and the time that each communication between nodes takes along an implemented scatternet. This technique is not only valid for Bluetooth networks but also for other wireless networks that offer access to their middleware in order to include beacons in the operation of the nodes. We show in this Note the results of the tests carried out on a Bluetooth scatternet in order to highlight the reliability and effectiveness of the methodology. The results also validate this technique showing convergence in the results when subtracting the time for the beacons from the delay measurements.
Full Text Available Abstract Background The growing need for functional studies of genes has set the stage for the development of versatile tools for genetic manipulations. Results Aiming to provide tools for high throughput analysis of gene functions, we have developed a modified short hairpin RNA (shRNA and gene expression system based on Gateway Technology. The system contains a series of entry and destination vectors that enables easy transfer of shRNA or cDNA into lentiviral expression systems with a variety of selection or marker genes (i.e. puromycin, hygromycin, green fluorescent protein-EGFP, yellow fluorescent protein-YFP and red fluorescent protein-dsRed2. Our shRNA entry vector pENTR.hU6.hH1 containing two tandem human shRNA expression promoters, H1 and U6, was capable of co-expressing two shRNA sequences simultaneously. The entry vector for gene overexpression, pENTR.CMV.ON was constructed to contain CMV promoter with a multiple cloning site flanked by loxP sites allowing for subsequent Cre/lox recombination. Both shRNA and cDNA expression vectors also contained attL sites necessary for recombination with attR sites in our destination expression vectors. As proof of principle we demonstrate the functionality and efficiency of this system by testing expression of several cDNA and shRNA sequences in a number of cell lines. Conclusion Our system is a valuable addition to already existing library of Gateway based vectors and can be an essential tool for many aspects of gene functional studies.
Radulovich, Nikolina; Leung, Lisa; Tsao, Ming-Sound
The growing need for functional studies of genes has set the stage for the development of versatile tools for genetic manipulations. Aiming to provide tools for high throughput analysis of gene functions, we have developed a modified short hairpin RNA (shRNA) and gene expression system based on Gateway Technology. The system contains a series of entry and destination vectors that enables easy transfer of shRNA or cDNA into lentiviral expression systems with a variety of selection or marker genes (i.e. puromycin, hygromycin, green fluorescent protein-EGFP, yellow fluorescent protein-YFP and red fluorescent protein-dsRed2). Our shRNA entry vector pENTR.hU6.hH1 containing two tandem human shRNA expression promoters, H1 and U6, was capable of co-expressing two shRNA sequences simultaneously. The entry vector for gene overexpression, pENTR.CMV.ON was constructed to contain CMV promoter with a multiple cloning site flanked by loxP sites allowing for subsequent Cre/lox recombination. Both shRNA and cDNA expression vectors also contained attL sites necessary for recombination with attR sites in our destination expression vectors. As proof of principle we demonstrate the functionality and efficiency of this system by testing expression of several cDNA and shRNA sequences in a number of cell lines. Our system is a valuable addition to already existing library of Gateway based vectors and can be an essential tool for many aspects of gene functional studies.
Ewert, Michael; Broyan, James; Goodliff, Kandyce; Clowdsley, Martha; Singleterry, Robert
Taking out the trash at NASA's newly proposed Deep Space Gateway (DSG) will not be a trivial task. While not the most important aspect of planning this cislunar outpost, there are several options that should be carefully considered since they may affect the crew as well as mission mass and volume. This study extends an earlier one, which focused on waste disposal options for a Mars Transit Vehicle. In that study, gasifying and venting trash along the way was found to noticeably reduce propellant needs and launch mass, whereas keeping processed trash on board in the form of radiation shielding tiles would significantly lower the crew's radiation dose during a solar particle event. Another favorable strategy was packing trash in a used logistics module for disposal. Since the DSG does not need much propulsion to maintain its orbit and Orion will be present with its own radiation storm shelter at the Gateway, the driving factors of the waste disposal trade study are different than for the Mars mission. Besides reviewing the propulsion and radiation shielding factors, potential drivers such as mass, power, volume, crew time, and human factors (e.g. smell) were studied. Disposal options for DSG include jettison of a used logistics module containing waste after every human stay, jettison of the same logistics module after several missions once it is full, regular disposal of trash via an airlock, or gasifying waste products for easier disposal or reuse. Conversely, a heat melt compactor device could be used to remove water and stabilize trash into tiles which could be more compactly stored on board and used as radiation shielding. Equivalent system mass analysis is used to tally the benefits and costs (mass, volume, power, crew time) of each case on an equivalent mass basis. Other more subjective factors are also discussed. Recommendations are made for DSG and Mars mission waste disposal.
Stafford, K.; Laidre, K. L.; Moore, S. E.
Changes in sea ice phenology have been profound in regions north of arctic gateways, where the seasonal open-water period has increased by 1.5-3 months over the past 30 years. This has resulted in changes to the Arctic ecosystem, including increased primary productivity, changing food web structure, and opening of new habitat. In the "new normal" Arctic, ice obligate species such as ice seals and polar bears may fare poorly under reduced sea ice while sub-arctic "summer" whales (fin and humpback) are poised to inhabit new seasonal ice-free habitats in the Arctic. We examined the spatial and seasonal occurrence of summer and "winter" (bowhead) whales from September through December by deploying hydrophones in three Arctic gateways: Bering, Davis and Fram Straits. Acoustic occurrence of the three species was compared with decadal-scale changes in seasonal sea ice. In all three Straits, fin whale acoustic detections extended from summer to late autumn. Humpback whales showed the same pattern in Bering and Davis Straits, singing into November and December, respectively. Bowhead whale detections generally began after the departure of the summer whales and continued through the winter. In all three straits, summer whales occurred in seasons and regions that used to be ice-covered. This is likely due to both increased available habitat from sea ice reductions and post-whaling population recoveries. At present, in the straits examined here, there is spatial, but not temporal, overlap between summer and winter whales. In a future with further seasonal sea ice reductions, however, increased competition for resources between sub-Arctic and Arctic species may arise to the detriment of winter whales.
Barbera, Roberto; Bruno, Riccardo; Calanducci, Antonio; Messina, Antonio; Pappalardo, Marco; Passaro, Gianluca
The EarthServer project (www.earthserver.eu), funded by the European Commission under its Seventh Framework Program, aims at establishing open access and ad-hoc analytics on extreme-size Earth Science data, based on and extending leading-edge Array Database technology. The core idea is to use database query languages as client/server interface to achieve barrier-free "mix & match" access to multi-source, any-size, multi-dimensional space-time data -- in short: "Big Earth Data Analytics" - based on the open standards of the Open Geospatial Consortium Web Coverage Processing Service (OGC WCPS) and the W3C XQuery. EarthServer combines both, thereby achieving a tight data/metadata integration. Further, the rasdaman Array Database System (www.rasdaman.com) is extended with further space-time coverage data types. On server side, highly effective optimizations - such as parallel and distributed query processing - ensure scalability to Exabyte volumes. Six Lighthouse Applications are being established in EarthServer, each of which poses distinct challenges on Earth Data Analytics: Cryospheric Science, Airborne Science, Atmospheric Science, Geology, Oceanography, and Planetary Science. Altogether, they cover all Earth Science domains; the Planetary Science use case has been added to challenge concepts and standards in non-standard environments. In addition, EarthLook (maintained by Jacobs University) showcases use of OGC standards in 1D through 5D use cases. In this contribution we will report on the first applications integrated in the EarthServer Science Gateway and on the clients for mobile appliances developed to access them. We will also show how federated and social identity services can allow Big Earth Data Providers to expose their data in a distributed environment keeping a strict and fine-grained control on user authentication and authorisation. The degree of fulfilment of the EarthServer implementation with the recommendations made in the recent TERENA Study on
Jones, Kerina H; Ford, David V; Jones, Chris; Dsilva, Rohan; Thompson, Simon; Brooks, Caroline J; Heaven, Martin L; Thayer, Daniel S; McNerney, Cynthia L; Lyons, Ronan A
With the current expansion of data linkage research, the challenge is to find the balance between preserving the privacy of person-level data whilst making these data accessible for use to their full potential. We describe a privacy-protecting safe haven and secure remote access system, referred to as the Secure Anonymised Information Linkage (SAIL) Gateway. The Gateway provides data users with a familiar Windows interface and their usual toolsets to access approved anonymously-linked datasets for research and evaluation. We outline the principles and operating model of the Gateway, the features provided to users within the secure environment, and how we are approaching the challenges of making data safely accessible to increasing numbers of research users. The Gateway represents a powerful analytical environment and has been designed to be scalable and adaptable to meet the needs of the rapidly growing data linkage community. Copyright © 2014 The Aurthors. Published by Elsevier Inc. All rights reserved.
Head, J. W.; Pieters, C. M.; Scott, D. R.
We outline an Orientale Basin Human/Robotic Architecture that can be facilitated by a Deep Space Gateway International Science Operations Center (DSG-ISOC) (like McMurdo/Antarctica) to address fundamental scientific problems about the Moon and Mars.
Sibille, L.; Mantovani, J. G.; Townsend, I. I.; Mueller, R. P.
The concepts describe hardware and instrumentation for the study of planetary surface materials at the Deep Space Gateway as a progressive evolution of capabilities for eliminating the need for special handling and Planetary Protection (PP) protocols inside the habitats.
Jones, Kerina H.; Ford, David V.; Jones, Chris; Dsilva, Rohan; Thompson, Simon; Brooks, Caroline J.; Heaven, Martin L.; Thayer, Daniel S.; McNerney, Cynthia L.; Lyons, Ronan A.
With the current expansion of data linkage research, the challenge is to find the balance between preserving the privacy of person-level data whilst making these data accessible for use to their full potential. We describe a privacy-protecting safe haven and secure remote access system, referred to as the Secure Anonymised Information Linkage (SAIL) Gateway. The Gateway provides data users with a familiar Windows interface and their usual toolsets to access approved anonymously-linked datasets for research and evaluation. We outline the principles and operating model of the Gateway, the features provided to users within the secure environment, and how we are approaching the challenges of making data safely accessible to increasing numbers of research users. The Gateway represents a powerful analytical environment and has been designed to be scalable and adaptable to meet the needs of the rapidly growing data linkage community. PMID:24440148
Fog computing extends cloud computing to the edge of a network enabling new Internet of Things (IoT) applications and services, which may involve critical data that require privacy and security. In an IoT fog computing system, three elements can be distinguished: IoT nodes that collect data, the cloud, and interconnected IoT gateways that exchange messages with the IoT nodes and with the cloud. This article focuses on securing IoT gateways, which are assumed to be constrained in terms of computational resources, but that are able to offload some processing from the cloud and to reduce the latency in the responses to the IoT nodes. However, it is usually taken for granted that IoT gateways have direct access to the electrical grid, which is not always the case: in mission-critical applications like natural disaster relief or environmental monitoring, it is common to deploy IoT nodes and gateways in large areas where electricity comes from solar or wind energy that charge the batteries that power every device. In this article, how to secure IoT gateway communications while minimizing power consumption is analyzed. The throughput and power consumption of Rivest–Shamir–Adleman (RSA) and Elliptic Curve Cryptography (ECC) are considered, since they are really popular, but have not been thoroughly analyzed when applied to IoT scenarios. Moreover, the most widespread Transport Layer Security (TLS) cipher suites use RSA as the main public key-exchange algorithm, but the key sizes needed are not practical for most IoT devices and cannot be scaled to high security levels. In contrast, ECC represents a much lighter and scalable alternative. Thus, RSA and ECC are compared for equivalent security levels, and power consumption and data throughput are measured using a testbed of IoT gateways. The measurements obtained indicate that, in the specific fog computing scenario proposed, ECC is clearly a much better alternative than RSA, obtaining energy consumption reductions of up
Suárez-Albela, Manuel; Fernández-Caramés, Tiago M; Fraga-Lamas, Paula; Castedo, Luis
Fog computing extends cloud computing to the edge of a network enabling new Internet of Things (IoT) applications and services, which may involve critical data that require privacy and security. In an IoT fog computing system, three elements can be distinguished: IoT nodes that collect data, the cloud, and interconnected IoT gateways that exchange messages with the IoT nodes and with the cloud. This article focuses on securing IoT gateways, which are assumed to be constrained in terms of computational resources, but that are able to offload some processing from the cloud and to reduce the latency in the responses to the IoT nodes. However, it is usually taken for granted that IoT gateways have direct access to the electrical grid, which is not always the case: in mission-critical applications like natural disaster relief or environmental monitoring, it is common to deploy IoT nodes and gateways in large areas where electricity comes from solar or wind energy that charge the batteries that power every device. In this article, how to secure IoT gateway communications while minimizing power consumption is analyzed. The throughput and power consumption of Rivest-Shamir-Adleman (RSA) and Elliptic Curve Cryptography (ECC) are considered, since they are really popular, but have not been thoroughly analyzed when applied to IoT scenarios. Moreover, the most widespread Transport Layer Security (TLS) cipher suites use RSA as the main public key-exchange algorithm, but the key sizes needed are not practical for most IoT devices and cannot be scaled to high security levels. In contrast, ECC represents a much lighter and scalable alternative. Thus, RSA and ECC are compared for equivalent security levels, and power consumption and data throughput are measured using a testbed of IoT gateways. The measurements obtained indicate that, in the specific fog computing scenario proposed, ECC is clearly a much better alternative than RSA, obtaining energy consumption reductions of up to
Background Valuable clone collections encoding the complete ORFeomes for some model organisms have been constructed following the completion of their genome sequencing projects. These libraries are based on Gateway cloning technology, which facilitates the study of protein function by simplifying the subcloning of open reading frames (ORF) into any suitable destination vector. The expression of proteins of interest as fusions with functional modules is a frequent approach in their initial functional characterization. A limited number of Gateway destination expression vectors allow the construction of fusion proteins from ORFeome-derived sequences, but they are restricted to the possibilities offered by their inbuilt functional modules and their pre-defined model organism-specificity. Thus, the availability of cloning systems that overcome these limitations would be highly advantageous. Results We present a versatile cloning toolkit for constructing fully-customizable three-part fusion proteins based on the MultiSite Gateway cloning system. The fusion protein components are encoded in the three plasmids integral to the kit. These can recombine with any purposely-engineered destination vector that uses a heterologous promoter external to the Gateway cassette, leading to the in-frame cloning of an ORF of interest flanked by two functional modules. In contrast to previous systems, a third part becomes available for peptide-encoding as it no longer needs to contain a promoter, resulting in an increased number of possible fusion combinations. We have constructed the kit’s component plasmids and demonstrate its functionality by providing proof-of-principle data on the expression of prototype fluorescent fusions in transiently-transfected cells. Conclusions We have developed a toolkit for creating fusion proteins with customized N- and C-term modules from Gateway entry clones encoding ORFs of interest. Importantly, our method allows entry clones obtained from ORFeome
Bhatt, Jay; Manion, Mark; Fromm, Eli
At Drexel University, the present undergraduate engineering curriculum has evolved from the Enhanced Educational Experience for Engineering Students (E4) project and the Gateway Engineering Education Coalition, both National Science Foundation (NSF) funded initiatives to re-engineer undergraduate engineering education. Since its institutionalization in 1994, the curriculum has served as a model for an integrated lower-division engineering curriculum. One aspect of engineering education propos...
ten Bruggencate, J
"PreciseMail Anti-Spam Gateway uses a combination of proven heuristic (rules-based) and artificial intelligence technologies that eliminates unwanted spam e-mail at an Internet gateway without filtering critical e-mail messages. Its highly effective filtering engine identifies spam and allows multiple levels of tuning and customization to meet each user's personal e-mail spam filtering requirements" (1 page).
Atsmon, Jacob; Caraco, Yoseph; Ziv-Sefer, Sagit; Shaikevich, Dimitry; Abramov, Ester; Volokhov, Inna; Bruzil, Svetlana; Haima, Kirsten Y; Gottlieb, Tanya; Ben-Yedidia, Tamar
A new vaccine, "Multimeric-001" (M-001) has been recently developed, containing conserved, common linear influenza epitopes that activate both cellular and humoral arms of the immune system against a wide variety of influenza A and B strains. Apart from its direct action, M-001 is an attractive candidate for priming immune responses to seasonal influenza vaccine for the elderly population. The current clinical study was designed to assess M-001's standalone and priming action in participants over 65 years old. Evaluation of standalone action is based on induction of cell mediated immunity (CMI), since M-001 alone does not induce hemagglutinin inhibition (HAI) antibodies. This was a two-center, randomized, placebo-controlled study. 120 participants were randomized 1:1:1:1 into four groups to receive either two sequential non-adjuvanted or a single non-adjuvanted or a single adjuvanted intramuscular injection of 500 mcg M-001 (treatment), or one placebo (saline) injection, before receiving the trivalent inactivated influenza vaccine (TIV). Due to visual differences between placebo and treatment the study was partially blinded. HAI was evaluated at baseline and 3 weeks after standard TIV vaccination as a measure of M-001's efficacy. CMI responses were evaluated in a subset (10/group) of the participants. Participants were monitored for safety throughout the study. Overall the treatment was well-tolerated and safe, though sample sizes allowed only limited statistical analysis. M-001 priming resulted in enhanced seroconversion towards all three TIV strains, compared to priming with placebo. Significant elevation of influenza-specific CMI was observed following immunization with M-001 alone. The standalone and priming actions of M-001 were demonstrated in elderly participants despite the limitations of small population size and pre-existing HAI antibody titers in some participants. As a standalone vaccine, M-001 induced significant CMI to multiple strains and as a primer, M-001 enhanced HAI responses. Larger scale studies are warranted. NCT01419925. Copyright © 2014 Elsevier Ltd. All rights reserved.
Buntru, Matthias; Gärtner, Stefanie; Staib, Lena; Kreuzaler, Fritz; Schlaich, Nikolaus
At present, only few methods for the effective assembly of multigene constructs have been described. Here we present an improved version of the MultiRound Gateway technology, which facilitates plant multigene transformation. The system consists of two attL-flanked entry vectors, which contain an attR cassette, and a transformation-competent artificial chromosome based destination vector. By alternate use of the two entry vectors, multiple transgenes can be delivered sequentially into the Gateway-compatible destination vector. Multigene constructs that carried up to seven transgenes corresponding to more than 26 kb were assembled by seven rounds of LR recombination. The constructs were successfully transformed into tobacco plants and were stably inherited for at least two generations. Thus, our system represents a powerful, highly efficient tool for multigene plant transformation and may facilitate genetic engineering of agronomic traits or the assembly of genetic pathways for the production of biofuels, industrial or pharmaceutical compounds in plants.
Fowler, Daniel K; Stewart, Scott; Seredick, Steve; Eisen, Judith S; Stankunas, Kryn; Washbourne, Philip
Recombination-based cloning is a quick and efficient way to generate expression vectors. Recent advancements have provided powerful recombinant DNA methods for molecular manipulations. Here, we describe a novel collection of three-fragment MultiSite Gateway cloning system-compatible vectors providing expanded molecular tools for vertebrate research. The components of this toolkit encompass a broad range of uses such as fluorescent imaging, dual gene expression, RNA interference, tandem affinity purification, chemically-inducible dimerization and lentiviral production. We demonstrate examples highlighting the utility of this toolkit for producing multi-component vertebrate expression vectors with diverse primary research applications. The vectors presented here are compatible with other Gateway toolkits and collections, facilitating the rapid generation of a broad range of innovative DNA constructs for biological research.
Daniel K Fowler
Full Text Available Recombination-based cloning is a quick and efficient way to generate expression vectors. Recent advancements have provided powerful recombinant DNA methods for molecular manipulations. Here, we describe a novel collection of three-fragment MultiSite Gateway cloning system-compatible vectors providing expanded molecular tools for vertebrate research. The components of this toolkit encompass a broad range of uses such as fluorescent imaging, dual gene expression, RNA interference, tandem affinity purification, chemically-inducible dimerization and lentiviral production. We demonstrate examples highlighting the utility of this toolkit for producing multi-component vertebrate expression vectors with diverse primary research applications. The vectors presented here are compatible with other Gateway toolkits and collections, facilitating the rapid generation of a broad range of innovative DNA constructs for biological research.
Mayet, Aurélie; Legleye, Stéphane; Beck, François; Falissard, Bruno; Chau, Nearkasen
The aim of this study was to describe the transitions between tobacco (T), cannabis (C) and other illicit drugs (OIDs) initiations, to simultaneously explore several substance use theories: gateway theory (GT), common liability model (CLM) and route of administration model (RAM). Data from 2 French nationwide surveys conducted in 2005 and 2010 were used (16,421 subjects aged 18-34). Using reported ages at initiations, we reconstituted a retrospective cohort describing all initiation sequences between T, C and OID. Transition probabilities between the substances were computed using a Markov multi-state model that also tested the effect of 2 latent variables (item response theory scores reflecting propensity for early onset and further substance use) on all transitions. T initiation was associated with increased likelihood of subsequent C initiation, but the reverse relationship was also observed. While the most likely initiation sequence among subjects who initiated the 3 groups of substances was the 'gateway' sequence T x2192; C x2192; OID, this pattern was not associated with substance use propensity more than alternative sequences. Early use propensity was associated with the 'gateway' sequence but also with some alternative ones beginning with T, C or OID. If the gateway sequence appears as the most likely pattern, in line with GT, the effects of early onset and substance use propensities were also observed for some alternative sequences, which is more in line with CLM. RAM could explain reciprocal interactions observed between T and C. This suggests shared influences of individual (personality traits) and environmental (substance availability, peer influence) characteristics. © 2015 S. Karger AG, Basel.
Wilkerson, Andrea [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Davis, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Clark, Edward [ZGF Architects LLP, Seattle, WA (United States)
The GATEWAY program evaluated a tunable LED lighting system installed in the new Swedish Medical Behavioral Health Unit in Seattle that incorporates color-tunable luminaires in common areas, and uses advanced controls for dimming and color tuning, with the goal of providing a better environment for staff and patients. The report reviews the design of the tunable lighting system, summarizes two sets of measurements, and discusses the circadian, energy, and commissioning implications as well as lessons learned from the project.
Full Text Available Sistem link balancing dan failover merupakan salah satu cara yang dapat digunakan untuk membagi beban traffic dari client pada beberapa koneksi internet, dapat sebagai backup/failover ketika salah satu koneksi internet mengalami gangguan. Pada perancangan sistem ini digunakan 4 buah router, yaitu terdiri dari satu router cisco 7606s yang berfungsi sebagai main gateway yang mengatur sistem failover dan link balancing menuju ke 2 buah router mikrotik RB951G 2HND sebagai jalur kedua ISP dan router mikrotik CCR1036-12G-4S sebagai gateway dari FTP server. Tiap router tersebut memiliki Autonomus System Number yang berbeda yang saling berkomunikasi menggunakan routing Border Gateway Protocol (BGP. Dari hasil pengujian penggunaan link balancing dengan besar bandwidth 10 mb/s, didapatkan throughput 794 KB/s, sedangkan yang tidak menggunakan link balancing dengan bandwidth sebesar 20 mb/s, didapatkan nilai throughput hanya 136 KB/s. Penggunaan link balancing dapat memanfaatkan besar bandwidth yang ada dan meningkatkan throughput, dibandingkan tidak menggunkan link balancing. Pada pengujian delay, menggunakan link balancing hanya delay 1.24 ms, sedangkan tidak menggunakan metode link balancing mencapai 8.19 ms. Nilai latency didapatkan 12 ms untuk menggunakan link balancing sedangkan tidak menggunkan metode link balancing mencapai 1896 ms.
As an opening of a dialogue on health reforms in Pakistan, the Gateway Paper presents a viewpoint on its proposed directions making a strong case for systems reforms, which need to scope beyond the healthcare system. Positioning the reform process to strengthen Pakistan's health policy cycle, the paper articulates a roadmap for a paradigm shift to achieve health outcomes in Pakistan with major structural reorganization within the health system. The proposed reform points in the four areas namely, reforms within the health sector, overarching measures, reconfiguration of health within an inter-sectoral scope and generating evidence for reforms. Reforms within the health sector focus on developing new models of service delivery and health financing which can enable the state to leverage the private sector outreach to deliver health-related public goods on the one hand and maximize the outreach of the State's health care delivery mechanisms through mainstreaming the role of the private sector on the other, albeit with safeguards. In addition, these call for strengthening the stewardship role to regulate these arrangements. The second area of reform focuses on overarching measures; these include developing frameworks for public-private partnerships which will enable the bringing together of organizations with the mandate to offer public goods and those that could facilitate this goal through the provision of resources, technical expertise or outreach; mainstreaming health into the country's social protection strategy in order to address issues of access and affordability for the poor and introducing civil service and public service reform focused on good governance, accountability, breakdown of institutional corruption which are critical to improving health outcomes. The third area of reform involves broadening health to its inter-sectoral scope, redefinition of objectives and targets within the health sector and garnering support from across the sectors to forester
Turcan, Romeo V.; Gulieva, Valeria
Turcan and Gulieva deepen our theoretical understanding of the process of university internationalisation by exploring the relationship between university internationalisation and university autonomy. They conjecture that the process of university internationalisation and its sustainability are d...
A GPIB device support module is used to provide access to the operating parameters of a GPIB device. GPIB devices may be accessed via National Instruments 1014 cards or via Bitbus Universal Gateways. GPIB devices typically have many parameters, each of which may be thought of in terms of the standard types of database records available in EPICS. It is the job of the device support module designer to decide how the mapping of these parameters will be made to the available record types. Once this mapping is complete, the device support module may be written. The writing of the device support module consists primarily of the construction of a parameter table. This table is used to associate the database record types with the operating parameters of the GPIB instrument. Other aspects of module design include the handling of SRQ events and errors. SRQ events are made available to the device support module if so desired. The processing of an SRQ event is completely up to the designer of the module. They may be ignored, tied to event based record processing, or anything else the designer wishes. Error conditions may be handled in a similar fashion
Zhao, Liang; Ng, Ee Ting; Koopman, Peter
Bacterial artificial chromosomes (BACs) have become increasingly popular vectors for making transgenic mice, as they are able to carry large genomic DNA fragments that in many cases are needed to reproduce the endogenous gene expression pattern. However, the efficiency of BAC transgenesis is generally low, and gene transfer to BAC vectors by recombination-mediated engineering (recombineering) is time-consuming and technically demanding. We present an enhanced system, comprising a BAC vector retrofitted with piggyBac DNA transposon elements and attL (Gateway) docking sites, that obviates these problems. Using this system, a gene-of-interest (such as a reporter gene) is transferred to the vector in a one-step in vitro reaction, and piggyBac transposition mediates transgene integration at high efficiency when microinjected into mouse zygotes with piggyBac transposase mRNA. We establish proof-of-principle for this system using a Wilms tumour-1 (Wt1) BAC to drive expression of an mCherry-2A-EGFP (RG) reporter gene, which yielded transgenic mice at a frequency of 33%, and recapitulated endogenous WT1 expression in developing gonads, kidneys and heart. The system we describe is applicable to any BAC transgenesis strategy. Copyright © 2014 Wiley Periodicals, Inc.
Importance of ancient and historical maps is nowadays recognized in many applications (e.g., urban planning, landscape valorisation and preservation, land changes identification, etc.). In the last years a great effort has been done by different institutions, such as Geographical Institutes, Public Administrations, and collaborative communities, for digitizing and publishing online collections of historical maps. In spite of this variety and availability of data, information overload makes difficult their discovery and management: without knowing the specific repository where the data are stored, it is difficult to find the information required. In addition, problems of interconnection between different data sources and their restricted interoperability may arise. This paper describe a new brokering based gateway developed to assure interoperability between data, in particular georeferenced historical maps and geographic data, gathered from different data providers, with various features and referring to different historical periods. The developed approach is exemplified by a new application named GeoPAN Atl@s that is aimed at linking in Northern Italy area land changes with risk analysis (local seismicity amplification and flooding risk) by using multi-temporal data sources and historic maps.
Rosario G. Garroppo
Full Text Available In modern houses, the presence of sensors and actuators is increasing, while communication services and entertainment systems had long since settled into everyday life. The utilization of wireless communication technologies, such as ZigBee, Wi-Fi, and Bluetooth, is attractive because of their short installation times and low costs. The research is moving towards the integration of the various home appliances and devices into a single domotics system, able to exploit the cooperation among the diverse subsystems and offer the end-user a single multiservice platform. In this scenario, the paper presents the experimental evaluation of a domotics framework centered on a SIP-based home gateway (SHG. While SIP is used to build a common control plane, the SHG is in charge of translating the user commands from and to the specific domotics languages. The analysis has been devoted to assess both the performance of the SHG software framework and the negative effects produced by the simultaneous interference among the three widespread wireless technologies.
Levy, Aharon; Saguy, Tamar; Halperin, Eran; van Zomeren, Martijn
The modern era of globalization has been accompanied by a massive growth in interconnections between groups, and has led to the sharing of multiple identities by individuals and groups. Following these developments, research has focused on the issue of multiple identities, and has shed important light on how individuals who hold these complex forms of identity feel and behave, and on the reactions they elicit from members of other groups. However, the potential of groups with such multiple identities (e.g., biracials, immigrants, etc.) to affect the intergroup relations between the groups that represent the respective sources of the different identities (e.g., Blacks and Whites, country of origin and country of residence, etc.) has not been examined to date. Accordingly, in this paper, we first systematically explore the potential of groups in which people identify with multiple social categories, or groups that are perceived as such by others, to play a role in intergroup dynamics. Next, we offer a theoretical framework outlining what functions groups of people with shared multiple identities may serve (as bridges or barriers ) by proposing how their presence may facilitate or deteriorate intergroup relations. Finally, we present recent empirical research examining how groups of people with shared multiple identities can act as gateways and bridge the cleft between two separate groups that represent the respective sources of their different identities, and discuss the theoretical and practical implications for the field of intergroup relations.
Full Text Available With the construction of firm and intelligent power grid in China, it is difficult for the traditional management method of electrical energy metering device to meet the prospecting requirements. Using the computer and internet techniques to realize the information and intelligentization of the electrical energy metering management has become a necessary guarantee of improving power supply ability, marketing control, and customer service. This paper introduced a kind of large and intelligent condition management system of the gateway electrical energy metering device. The key technologies and realize process were analyzed. Moreover, a detailed description of the application modules such as the GIS smart display of metering point, the condition management of metering devices and the visual monitoring of metering point was presented. The trial operation in the selected transformer substations and the power stations of Chongqing Power Electrical Corp. indicated that, the condition management system is very open, safety and efficient. According to the data exchange with the production and scheduling platform, the system improved the efficient operation of the electrical energy metering devices. Meanwhile, combined with the real-time visual monitoring, the condition management system improved the prevention ability of electricity filching, realized the unified automatic large-scale management of electrical energy metering devices.
Full Text Available Unionised work environments within large seaports attract transnational organised crime, and this presents a challenge for law enforcement agencies. If media stories are true, a motorcycle club called the Hells Angels has established a presence on Vancouver area waterfronts since coming to the province of British Columbia. Associations between longshore union locals, club members, and known contacts are implied and presented as evidence of participation in criminality. This paper revisits the perception that criminal activity is endemic in the Port of Vancouver because of a lack of policing, adequate resources, and indifference from port authorities, employer bodies, as well as union leadership. In an era of heightened concerns about public safety and national security, federal and provincial governments understand the importance of seaports, especially in Vancouver and up the Fraser River. These port facilities are important to international trade that flows through them as part of Asia-Pacific Gateway and Corridor initiatives. Therefore, targeted investments, close coordination amongst government departments and agencies, and engagement with waterfront stakeholders promote secure places hard for organised criminals to operate freely.
Yue, Xiao; Wang, Huiju; Jin, Dawei; Li, Mingqiang; Jiang, Wei
Healthcare data are a valuable source of healthcare intelligence. Sharing of healthcare data is one essential step to make healthcare system smarter and improve the quality of healthcare service. Healthcare data, one personal asset of patient, should be owned and controlled by patient, instead of being scattered in different healthcare systems, which prevents data sharing and puts patient privacy at risks. Blockchain is demonstrated in the financial field that trusted, auditable computing is possible using a decentralized network of peers accompanied by a public ledger. In this paper, we proposed an App (called Healthcare Data Gateway (HGD)) architecture based on blockchain to enable patient to own, control and share their own data easily and securely without violating privacy, which provides a new potential way to improve the intelligence of healthcare systems while keeping patient data private. Our proposed purpose-centric access model ensures patient own and control their healthcare data; simple unified Indicator-Centric Schema (ICS) makes it possible to organize all kinds of personal healthcare data practically and easily. We also point out that MPC (Secure Multi-Party Computing) is one promising solution to enable untrusted third-party to conduct computation over patient data without violating privacy.
Ueda, Minoru; Inoue, Keisuke; Ishida, Sakiko; Nishimura, Yoshiki; Shikanai, Toshiharu; Kohchi, Takayuki
We previously reported Agrobacterium-mediated transformation methods for the liverwort Marchantia polymorpha using the hygromycin phosphotransferase gene as a marker for selection with hygromycin. In this study, we developed three additional markers for M. polymorpha transformation: the gentamicin 3'-acetyltransferase gene for selection with gentamicin; a mutated acetolactate synthase gene for selection with chlorsulfuron; and the neomycin phosphotransferase II gene for selection with G418. Based on these four marker genes, we have constructed a series of Gateway binary vectors designed for transgenic experiments on M. polymorpha. The 35S promoter from cauliflower mosaic virus and endogenous promoters for constitutive and heat-inducible expression were used to create these vectors. The reporters and tags used were Citrine, 3×Citrine, Citrine-NLS, TagRFP, tdTomato, tdTomato-NLS, GR, SRDX, SRDX-GR, GUS, ELuc(PEST), and 3×FLAG. These vectors, designated as the pMpGWB series, will facilitate molecular genetic analyses of the emerging model plant M. polymorpha. PMID:26406247
Giuraniuc, Claudiu V.; MacPherson, Murray; Saka, Yasushi
Construction of synthetic genetic networks requires the assembly of DNA fragments encoding functional biological parts in a defined order. Yet this may become a time-consuming procedure. To address this technical bottleneck, we have created a series of Gateway shuttle vectors and an integration vector, which facilitate the assembly of artificial genes and their expression in the budding yeast Saccharomyces cerevisiae. Our method enables the rapid construction of an artificial gene from a promoter and an open reading frame (ORF) cassette by one-step recombination reaction in vitro. Furthermore, the plasmid thus created can readily be introduced into yeast cells to test the assembled gene’s functionality. As flexible regulatory components of a synthetic genetic network, we also created new versions of the tetracycline-regulated transactivators tTA and rtTA by fusing them to the auxin-inducible degron (AID). Using our gene assembly approach, we made yeast expression vectors of these engineered transactivators, AIDtTA and AIDrtTA and then tested their functions in yeast. We showed that these factors can be regulated by doxycycline and degraded rapidly after addition of auxin to the medium. Taken together, the method for combinatorial gene assembly described here is versatile and would be a valuable tool for yeast synthetic biology. PMID:23675537
Benoy, Amrita; Dasgupta, Ananya; Sajikumar, Sreedharan
The hippocampus is a critical brain region for the formation of declarative memories. While social memory had long been attributed to be a function of the hippocampus, it is only of late that the area CA2 of the hippocampus was demarcated as essential for social memory formation. In addition to this distinct role, CA2 possesses unique molecular, structural and physiological characteristics compared to the other CA regions-CA1 and CA3, and the dentate gyrus (DG). CA2 pyramidal neurons are positioned at a location between CA1 and CA3, receiving inputs from CA3 and DG, in addition to forming a powerful disynaptic circuit with direct input from the entorhinal cortical layer II neurons. CA2 also receives direct inputs from the hypothalamic regions and displays a unique expression pattern for receptors for neuromodulators. The location, inputs, and molecular signatures of the area CA2 point to the possibility that CA2 serves as a modulatory gateway that processes information from the entorhinal cortex and CA3, before relaying them onto CA1, the major output of the hippocampus. This review discusses recent findings regarding plasticity and neuromodulation in the CA2 region of the hippocampus, and how this may have the potential to influence plasticity in connecting circuits, and thereby memory and behaviour.
Sidhu, Y S; Chaudhari, Y K; Usher, J; Cairns, T C; Csukai, M; Haynes, K
Gene overexpression is a widely used functional genomics approach in fungal biology. However, to date it has not been established in Zymoseptoria tritici which is an important pathogen of wheat (Triticum species). Here we report a suite of Gateway® recombination compatible ternary expression vectors for Agrobacterium tumefaciens mediated transformation of Z. tritici. The suite of 32 vectors is based on a combination of four resistance markers for positive selection against glufosinate ammonium, geneticin, hygromycin and sulfonylurea; three constitutive Z. tritici promoters (pZtATUB, pZtGAPDH and pZtTEF) and a nitrogen responsive promoter (pZtNIA1) for controlled expression of the open reading frames. Half of the vectors facilitate expression of proteins tagged with C-terminal EGFP. All 32 vectors allow high frequency targeting of the overexpression cassette into the Ku70 locus and complement the Ku70 gene when transformed into a Z. tritici ku70 null strain, thus circumventing additional phenotypes that can arise from random integration. This suite of ternary expression vectors will be a useful tool for functional analysis through gene overexpression in Z. tritici. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
Lynskey, Michael T; Agrawal, Arpana
During the early 1970s Denise Kandel and her colleagues documented an 'invariant sequence' in initiation of drug use: starting with alcohol and tobacco, progressing to cannabis and then to other illicit, or 'harder' drugs. This observation, which became known as the 'gateway sequence' of drug use, has been influential in policy debates but remains highly contentious, with the area of greatest controversy focusing upon whether cannabis use increases risk causally for initiation of other illicit drugs. While numerous studies have replicated Kandel's initial findings (sequence of onset) and reported that associations between cannabis use and the use of other illicit drugs remain after controlling for potentially confounding factors, the mechanisms underlying these observed associations remain hotly debated. In particular, it is possible that the observed associations are non-causal but reflect the influence of confounding factors which influence both early-onset drug use and subsequent progressions. However, research employing a range of techniques to address this issue has been unable to discount the possibility that associations between earlier and subsequent drug use reflect causal processes. This paper reviews Kandel's ongoing contributions to this field, which span 45 years, and discusses both the influence of her work and the controversy that it has aroused. © 2018 Society for the Study of Addiction.
Mooberry, Linda K; Sabnis, Nirupama A; Panchoo, Marlyn; Nagarajan, Bhavani; Lacko, Andras G
Malignant tumors display remarkable heterogeneity to the extent that even at the same tissue site different types of cells with varying genetic background may be found. In contrast, a relatively consistent marker the scavenger receptor type B1 (SR-B1) has been found to be consistently overexpressed by most tumor cells. Scavenger Receptor Class B Type I (SR-BI) is a high density lipoprotein (HDL) receptor that facilitates the uptake of cholesterol esters from circulating lipoproteins. Additional findings suggest a critical role for SR-BI in cholesterol metabolism, signaling, motility, and proliferation of cancer cells and thus a potential major impact in carcinogenesis and metastasis. Recent findings indicate that the level of SR-BI expression correlate with aggressiveness and poor survival in breast and prostate cancer. Moreover, genomic data show that depending on the type of cancer, high or low SR-BI expression may promote poor survival. This review discusses the importance of SR-BI as a diagnostic as well as prognostic indicator of cancer to help elucidate the contributions of this protein to cancer development, progression, and survival. In addition, the SR-B1 receptor has been shown to serve as a potential gateway for the delivery of therapeutic agents when reconstituted high density lipoprotein nanoparticles are used for their transport to cancer cells and tumors. Opportunities for the development of new technologies, particularly in the areas of cancer therapy and tumor imaging are discussed.
Ferreira, Pedro Henrique
My internship consisted of two major projects for the Launch Control System.The purpose of the first project was to implement the Application Control Language (ACL) to Activate Data Acquisition (ADA) and to Inhibit Data Acquisition (IDA) the Kennedy Ground Control Sub-Systems (KGCS) Gateway, to update existing Pad-B End Item Control (EIC) Display to program the ADA and IDA buttons with new ACL, and to test and release the ACL Display.The second project consisted of unit testing all of the Application Services Framework (ASF) by March 21st. The XmlFileReader was unit tested and reached 100 coverage. The XmlFileReader class is used to grab information from XML files and use them to initialize elements in the other framework elements by using the Xerces C++ XML Parser; which is open source commercial off the shelf software. The ScriptThread was also tested. ScriptThread manages the creation and activation of script threads. A large amount of the time was used in initializing the environment and learning how to set up unit tests and getting familiar with the specific segments of the project that were assigned to us.
Sangtarash, Sara; Vezzoli, Andrea; Sadeghi, Hatef; Ferri, Nicolò; O'Brien, Harry M; Grace, Iain; Bouffier, Laurent; Higgins, Simon J; Nichols, Richard J; Lambert, Colin J
If the factors controlling the decay in single-molecule electrical conductance G with molecular length L could be understood and controlled, then this would be a significant step forward in the design of high-conductance molecular wires. For a wide variety of molecules conducting by phase coherent tunnelling, conductance G decays with length following the relationship G = Ae -βL . It is widely accepted that the attenuation coefficient β is determined by the position of the Fermi energy of the electrodes relative to the energy of frontier orbitals of the molecular bridge, whereas the terminal anchor groups which bind to the molecule to the electrodes contribute to the pre-exponential factor A. We examine this premise for several series of molecules which contain a central conjugated moiety (phenyl, viologen or α-terthiophene) connected on either side to alkane chains of varying length, with each end terminated by thiol or thiomethyl anchor groups. In contrast with this expectation, we demonstrate both experimentally and theoretically that additional electronic states located on thiol anchor groups can significantly decrease the value of β, by giving rise to resonances close to E F through coupling to the bridge moiety. This interplay between the gateway states and their coupling to a central conjugated moiety in the molecular bridges creates a new design strategy for realising higher-transmission molecular wires by taking advantage of the electrode-molecule interface properties.
Hendro Tri Utomo
Full Text Available Tren bisnis online semakin meningkat seiring dengan perkembangan teknologi informasi. Di satu sisi, tren tersebut memberikan kemudahan dan kebebasan bagi konsumen dalam melakukan pembelian barang. Namun, disisi lain bisnis online juga memberikan resiko yang besar bagi konsumen. Berbagai modus penipuan online semakin marak, sementara dasar hukum yang mengaturnya masih baru dan belum tersosialisasikan dengan baik. Sehingga, diperlukan suatu upaya untuk memberikan sosialisasi dan perlindungan terhadap konsumen. Salah satu lembaga yang berperan aktif dalam upaya perlindungan konsumen adalah Komisi Nasional Perlindungan Konsumen dan Pelaku Usaha (KPKPU. KPKPU memberikan layanan pengaduan masalah, mediasi, sosialisasi hingga perlindungan hukum bagi konsumen. Kendala utama yang dihadapi KPKPU adalah masalah pelaporan yang tidak efisien (manual serta sosialisasi yang kurang cepat (karena keterbatasan sumber daya manusia. Berdasarkan kendala yang dimiliki oleh KPKPU, maka dibutuhkan sistem pengaduan konsumen online (IKOn yang efisien (otomatis sekaligus mampu menjadi media sosialisasi yang dapat menggalang peran serta masyarakat (tidak terbatas hanya sumberdaya KPKPU. Untuk memenuhi kebutuhan tersebut, IKOn dikembangkan dengan teknologi Facebook Open Graph Protocol (FOGP dan SMS Gateway. FOGP digunakan agar aplikasi dapat diintegrasikan didalam situs sosial media Facebook. Sehingga aplikasi dapat memberikan fitur sosial untuk sosialisasi informasi yang lebih cepat.
Vanyukov, Michael M.; Tarter, Ralph E.; Kirillova, Galina P.; Kirisci, Levent; Reynolds, Maureen D.; Kreek, Mary Jeanne; Conway, Kevin P.; Maher, Brion S.; Iacono, William G.; Bierut, Laura; Neale, Michael C.; Clark, Duncan B.; Ridenour, Ty A.
Background Two competing concepts address the development of involvement with psychoactive substances: the “gateway hypothesis” (GH) and common liability to addiction (CLA). Method The literature on theoretical foundations and empirical findings related to both concepts is reviewed. Results The data suggest that drug use initiation sequencing, the core GH element, is variable and opportunistic rather than uniform and developmentally deterministic. The association between risks for use of different substances, if any, can be more readily explained by common underpinnings than by specific staging. In contrast, the CLA concept is grounded in genetic theory and supported by data identifying common sources of variation in the risk for specific addictions. This commonality has identifiable neurobiological substrate and plausible evolutionary explanations. Conclusions Whereas the “gateway” hypothesis does not specify mechanistic connections between “stages”, and does not extend to the risks for addictions, the concept of common liability to addictions incorporates sequencing of drug use initiation as well as extends to related addictions and their severity, provides a parsimonious explanation of substance use and addiction co-occurrence, and establishes a theoretical and empirical foundation to research in etiology, quantitative risk and severity measurement, as well as targeted non-drug-specific prevention and early intervention. PMID:22261179
Barbera, Roberto; Bruno, Riccardo; Calanducci, Antonio; Fargetta, Marco; Pappalardo, Marco; Rundo, Francesco
The EarthServer project (www.earthserver.eu), funded by the European Commission under its Seventh Framework Program, aims at establishing open access and ad-hoc analytics on extreme-size Earth Science data, based on and extending leading-edge Array Database technology. The core idea is to use database query languages as client/server interface to achieve barrier-free "mix & match" access to multi-source, any-size, multi-dimensional space-time data -- in short: "Big Earth Data Analytics" - based on the open standards of the Open Geospatial Consortium Web Coverage Processing Service (OGC WCPS) and the W3C XQuery. EarthServer combines both, thereby achieving a tight data/metadata integration. Further, the rasdaman Array Database System (www.rasdaman.com) is extended with further space-time coverage data types. On server side, highly effective optimizations - such as parallel and distributed query processing - ensure scalability to Exabyte volumes. In this contribution we will report on the EarthServer Science Gateway Mobile, an app for both iOS and Android-based devices that allows users to seamlessly access some of the EarthServer applications using SAML-based federated authentication and fine-grained authorisation mechanisms.
Over the last several decades important information has been gathered by conducting life science experiments on the Space Shuttle and on the International Space Station. It is now time to leverage that scientific knowledge, as well as aspects of the hardware that have been developed to support the biological model systems, to NASA's next frontier - the Deep Space Gateway. In order to facilitate long duration deep space exploration for humans, it is critical for NASA to understand the effects of long duration, low dose, deep space radiation on biological systems. While carefully controlled ground experiments on Earth-based radiation facilities have provided valuable preliminary information, we still have a significant knowledge gap on the biological responses of organisms to chronic low doses of the highly ionizing particles encountered beyond low Earth orbit. Furthermore, the combined effects of altered gravity and radiation have the potential to cause greater biological changes than either of these parameters alone. Therefore a thorough investigation of the biological effects of a cis-lunar environment will facilitate long term human exploration of deep space.
Full Text Available The modern era of globalization has been accompanied by a massive growth in interconnections between groups, and has led to the sharing of multiple identities by individuals and groups. Following these developments, research has focused on the issue of multiple identities, and has shed important light on how individuals who hold these complex forms of identity feel and behave, and on the reactions they elicit from members of other groups. However, the potential of groups with such multiple identities (e.g., biracials, immigrants, etc. to affect the intergroup relations between the groups that represent the respective sources of the different identities (e.g., Blacks and Whites, country of origin and country of residence, etc. has not been examined to date. Accordingly, in this paper, we first systematically explore the potential of groups in which people identify with multiple social categories, or groups that are perceived as such by others, to play a role in intergroup dynamics. Next, we offer a theoretical framework outlining what functions groups of people with shared multiple identities may serve (as bridges or barriers by proposing how their presence may facilitate or deteriorate intergroup relations. Finally, we present recent empirical research examining how groups of people with shared multiple identities can act as gateways and bridge the cleft between two separate groups that represent the respective sources of their different identities, and discuss the theoretical and practical implications for the field of intergroup relations.
Full Text Available Objectives: According to the gateway drug theory, tobacco use is a predisposing factor for future substance abuse. This study was conducted to compare nicotine and opiate dependents to identify the differences between their personality traits and psychopathology that makes them turn to other substances after cigarette smoking. Methods: A causal-comparative study was conducted. Three groups were randomly selected: nicotine dependents, opiate dependents and ordinary individuals (non-dependent population. Cloninger’s Temperament and Character Inventory-Revised, the Fagerstrom Test for Nicotine Dependence, Maudsley Addiction Profile, the Beck Depression Inventory, and Beck Anxiety Inventory were used to collect data. Analysis of variance was used to analyze data. Results: Opiate dependents had higher ‘novelty seeking’ and lower ‘cooperativeness’ scores as compared to the other two groups. They also had higher anxiety and depression scores than the other two groups. Discussion: Higher ‘novelty seeking’ and lower ‘cooperativeness’ scores are important personality traits predicting
Claudiu V Giuraniuc
Full Text Available Construction of synthetic genetic networks requires the assembly of DNA fragments encoding functional biological parts in a defined order. Yet this may become a time-consuming procedure. To address this technical bottleneck, we have created a series of Gateway shuttle vectors and an integration vector, which facilitate the assembly of artificial genes and their expression in the budding yeast Saccharomyces cerevisiae. Our method enables the rapid construction of an artificial gene from a promoter and an open reading frame (ORF cassette by one-step recombination reaction in vitro. Furthermore, the plasmid thus created can readily be introduced into yeast cells to test the assembled gene's functionality. As flexible regulatory components of a synthetic genetic network, we also created new versions of the tetracycline-regulated transactivators tTA and rtTA by fusing them to the auxin-inducible degron (AID. Using our gene assembly approach, we made yeast expression vectors of these engineered transactivators, AIDtTA and AIDrtTA and then tested their functions in yeast. We showed that these factors can be regulated by doxycycline and degraded rapidly after addition of auxin to the medium. Taken together, the method for combinatorial gene assembly described here is versatile and would be a valuable tool for yeast synthetic biology.
María José Morón
Full Text Available This paper evaluates and characterizes the technical performance of medicalwireless personal area networks (WPANs that are based on smartphones. For this purpose,a prototype of a health telemonitoring system is presented. The prototype incorporates acommercial Android smartphone, which acts as a relay point, or “gateway”, between a setof wireless medical sensors and a data server. Additionally, the paper investigates if theconventional capabilities of current commercial smartphones can be affected by their useas gateways or “Holters” in health monitoring applications. Specifically, the profiling hasfocused on the CPU and power consumption of the mobile devices. These metrics havebeen measured under several test conditions modifying the smartphone model, the type ofsensors connected to the WPAN, the employed Bluetooth profile (SPP (serial port profile orHDP (health device profile, the use of other peripherals, such as a GPS receiver, the impactof the use of theWi-Fi interface or the employed method to encode and forward the data thatare collected from the sensors.
Miller, Naomi J.; Kaye, Stan; Coleman, Patricia; Wilkerson, Andrea M.; Perrin, Tess E.; Sullivan, Gregory P.
The U.S. DOE GATEWAY Demonstration Program supports demonstrations of high-performance solid-state lighting (SSL) products in order to develop empirical data and experience with the in-the-field applications of this advanced lighting technology. This report describes the process and results of the 2013 - 2014 GATEWAY demonstration of SSL technology in the Nadine McGuire Theatre and Dance Pavilion at the University of Florida, Gainesville, FL. The LED solutions combined with dimming controls utilized in four interior spaces - the Acting Studio, Dance Studio, Scene Shop, and Dressing Room - received high marks from instructors, students/performers, and reduced energy use in all cases. The report discusses in depth and detail of each project area including specifications, energy savings, and user observations. The report concludes with lessons learned during the demonstration.
Berners-Lee, Tim; Groff, Jean-Francois; Pollermann, Bernd
Purpose - The World-Wide Web (W-3) initiative is a practical project designed to bring a global information universe into existence using available technology. This paper seeks to describe the aims, data model, and protocols needed to implement the "web" and to compare them with various contemporary systems. Design/methodology/approach - Since Vannevar Bush's article, men have dreamed of extending their intellect by making their collective knowledge available to each individual by using machines. Computers provide us two practical techniques for human-knowledge interface. One is hypertext, in which links between pieces of text (or other media) mimic human association of ideas. The other is text retrieval, which allows associations to be deduced from the content of text. The W-3 ideal world allows both operations and provides access from any browsing platform. Findings - Various server gateways to other information systems have been produced, and the total amount of information available on the web is...
Telichenko Valeriy Ivanovich
Full Text Available The article gives the analysis of university rankings and defines the differences in evaluation methods and indicators of world ranking agencies, presents new approaches to making global rankings. It defines the position of MGSU in Russian universities TOP-100 ranking. University rankings are not simply information, but the evaluation instrument of quality of education, initiating the improvement of ranking position. It’s important for Russian Universities claiming for higher positions in the world rankings. MGSU position in universities ranking made the University administration consider thoroughly the University positioning in the system of higher education, in the categories of education and science and among possible employers of the university graduates.
Barrense-Dias, Yara; Berchtold, André; Akre, Christina; Surís, Joan-Carles
Adolescence is a transitory and exploratory stage during which risky behaviors such as substance use take place. This study aims to assess the characteristics and predictive risk factors of alcohol misuse among adolescents. A sample of 621 youths was followed from ages 14 to 16 years in Switzerland between spring 2012 (T0) and spring 2014 (T1). Participants were divided into two groups according to their alcohol misuse evolution: those who increased it (Misusers) and those who decreased or never experimented it (Non-misusers). The final sample consisted of 574 adolescents. At T0, participants reported demographic data, substance use data and emotional well-being. A multivariate regression was performed to assess the explanatory variables of alcohol misuse at T1 using Non-misusers as the reference category. Alcohol misuse in the previous month increased dramatically from 2.4% (T0) to 29.2% (T1). At the bivariate level, alcohol misuse was associated with residence, use of alcohol, tobacco and cannabis. Compared to Non-misusers, Misusers were significantly more likely to live in a rural area (aOR: 1.75 [1.1:2.8]), use cannabis (aOR: 3.2 [1.0:9.8]) and have consumed alcohol (aOR: 2.65 [1.6:4.3]) at T0. Alcohol misuse increases dramatically with age. However, the only demographic difference between groups was that young adolescents living in rural areas were more likely to misuse alcohol. Moreover, having consumed alcohol without drunkenness and using cannabis at age 14 years predicted alcohol misuse at age 16 years. This finding is in line with the reverse gateway theory, where cannabis use precedes the use of legal substances.
Fahmi, F.; Hizriadi, A.; Khairani, F.; Andayani, U.; Siregar, B.
Public clean water company (PDAM) as a public service is designed and organized to meet the needs of the community. Currently, the number of PDAM subscribers is very big and will continue to grow, but the service and facilities to customers are still done conventionally by visiting the customer’s home to record the last position of the meter. One of the problems of PDAM is the lack of disclosure of PDAM customers’ invoice because it is only done monthly. This, of course, makes PDAM customers difficult to remember the date of payment of water account. Therefore it is difficult to maintain the efficiency. The purpose of this research is to facilitate customers of PDAM water users to know the details of water usage and the time of payment of water bills easily. It also facilitates customers in knowing information related to the form of water discharge data used, payment rates, and time grace payments using SMS Gateway. In this study, Flow Liquid Meter Sensor was used for data retrieval of water flowing in the piping system. Sensors used to require the help of Hall Effect sensor that serves to measure the speed of water discharge and placed on the pipe that has the same diameter size with the sensor diameter. The sensor will take the data from the rate of water discharge it passes; this data is the number of turns of the mill on the sensor. The results of the tests show that the built system works well in helping customers know in detail the amount of water usage in a month and the bill to be paid
Soualmia, Lina F; Sakji, Saoussen; Letord, Catherine; Rollin, Laetitia; Massari, Philippe; Darmoni, Stéfan J
The Catalog and Index of French-language Health Internet resources (CISMeF) is a quality-controlled health gateway, primarily for Web resources in French (n=89,751). Recently, we achieved a major improvement in the structure of the catalogue by setting-up multiple terminologies, based on twelve health terminologies available in French, to overcome the potential weakness of the MeSH thesaurus, which is the main and pivotal terminology we use for indexing and retrieval since 1995. The main aim of this study was to estimate the added-value of exploiting several terminologies and their semantic relationships to improve Web resource indexing and retrieval in CISMeF, in order to provide additional health resources which meet the users' expectations. Twelve terminologies were integrated into the CISMeF information system to set up multiple-terminologies indexing and retrieval. The same sets of thirty queries were run: (i) by exploiting the hierarchical structure of the MeSH, and (ii) by exploiting the additional twelve terminologies and their semantic links. The two search modes were evaluated and compared. The overall coverage of the multiple-terminologies search mode was improved by comparison to the coverage of using the MeSH (16,283 vs. 14,159) (+15%). These additional findings were estimated at 56.6% relevant results, 24.7% intermediate results and 18.7% irrelevant. The multiple-terminologies approach improved information retrieval. These results suggest that integrating additional health terminologies was able to improve recall. Since performing the study, 21 other terminologies have been added which should enable us to make broader studies in multiple-terminologies information retrieval.
Cormier, M. H.; Blake, R. E.; Coleman, D. F.; Guerrier, K.; Raineault, N.; Saintilus, N.; Walker, S. L.; Auscavitch, S.; Wagner, J.
This August 2014, a 14-day expedition of the E/V NAUTILUS of the OCEAN EXPLORATION TRUST will explore the region delimited by two deep straits of the northern Caribbean, the Windward passage and the Jamaica Channel. The morphology of these straits is controlled by two transform faults: The Septentrional fault, which stretches between Cuba and Haiti (slip rate: ~13 mm/yr), and the Enriquillo-Plantain Garden Fault (EPGF), which stretches between Jamaica and Haiti (slip rate: ~9 mm/yr). Together, these faults bound the Gonave microplate, an elongated platelet caught between the North America plate and Caribbean plates. The Septentrional fault ruptured in 1842, devastating the town of Cap Haitien. The EPGF ruptured catastrophically in 2010 near Port-au-Prince (death toll > 100,000). Tsunamis were associated with both earthquakes. Oblique slip on these two faults is presumably controlling the history of uplift and subsidence of the seafloor, and has therefore also been regulating the water exchanges between the north central Atlantic and the Caribbean Sea. New multibeam bathymetric and CHIRP sub-bottom profiling data will be acquired with the E/V NAUTILUS, while the ROV HERCULES will be used to collect video, water and rock samples, as well as water column physical properties. We anticipate that this survey will document the following: (1) The nature of drowned carbonate platforms, which in turn may provide useful markers to assess rates of vertical deformation along the two faults. (2) The extent of major landslides detected on the steep fore reefs from existing multibeam bathymetric data. (3) Whether fluids are actively seeping along the fault traces or in association with the landslides, as has been reported elsewhere around the World. (4) If cold seeps are indeed present, to what extent their associated ecosystems are affected by the bottom currents that flow through these gateways. Altogether, the new findings should contribute to a better understanding of the
Fournier, Kimberly A; Couret, Jannelle; Ramsay, Jason B; Caulkins, Joshua L
Large enrollment foundational courses are perceived as "high stakes" because of their potential to act as barriers for progression to the next course or admittance to a program. The nature of gateway courses makes them ideal settings to explore the relationship between anxiety, pedagogical interventions, and student performance. Here, two-stage collaborative examinations were implemented to improve test-taking skills and address widespread test anxiety in an introductory human anatomy course. Test anxiety data were collected (using the Motivated Strategies for Learning Questionnaire) before the first examination and last examination. Most students experienced decreased test anxiety over the course of the semester; however, some students may have experienced performance limiting conditions due to test anxiety at the end of the semester based on academic ability in the course (in "C" students when compared to "A" students: P < 0.00006 and "B" students: P < 0.05), overall academic ability (in academically weaker students: P < 0.025), and demographic factors (in women: P < 0.025). The strongest performances on examinations were primarily observed in already academically strong students (mean individual performance: P < 0.000, mean group performance: P < 0.000). Furthermore, changes in test anxiety were not significantly associated with the group portion of the examinations. Patterns of changes in test anxiety over the course of the semester underscore a complex interaction between test anxiety, student background, and student performance. Results suggest that pathways for test anxiety in "high stakes" courses may be separate from the mechanisms responsible for the benefits of collaborative testing. Anat Sci Educ 10: 409-422. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.
Lescinsky, D. T.; Wyborn, L. A.; Evans, B. J. K.; Allen, C.; Fraser, R.; Rankine, T.
We present collaborative work on a generic, modular infrastructure for virtual laboratories (VLs, similar to science gateways) that combine online access to data, scientific code, and computing resources as services that support multiple data intensive scientific computing needs across a wide range of science disciplines. We are leveraging access to 10+ PB of earth science data on Lustre filesystems at Australia's National Computational Infrastructure (NCI) Research Data Storage Infrastructure (RDSI) node, co-located with NCI's 1.2 PFlop Raijin supercomputer and a 3000 CPU core research cloud. The development, maintenance and sustainability of VLs is best accomplished through modularisation and standardisation of interfaces between components. Our approach has been to break up tightly-coupled, specialised application packages into modules, with identified best techniques and algorithms repackaged either as data services or scientific tools that are accessible across domains. The data services can be used to manipulate, visualise and transform multiple data types whilst the scientific tools can be used in concert with multiple scientific codes. We are currently designing a scalable generic infrastructure that will handle scientific code as modularised services and thereby enable the rapid/easy deployment of new codes or versions of codes. The goal is to build open source libraries/collections of scientific tools, scripts and modelling codes that can be combined in specially designed deployments. Additional services in development include: provenance, publication of results, monitoring, workflow tools, etc. The generic VL infrastructure will be hosted at NCI, but can access alternative computing infrastructures (i.e., public/private cloud, HPC).The Virtual Geophysics Laboratory (VGL) was developed as a pilot project to demonstrate the underlying technology. This base is now being redesigned and generalised to develop a Virtual Hazards Impact and Risk Laboratory
Page, Janie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McParland, Chuck [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Piette, Mary Ann [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Czarnecki, Stephen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
With the widespread deployment of electronic interval meters, commonly known as smart meters, came the promise of real-time data on electric energy consumption. Recognizing an opportunity to provide consumers access to their near real-time energy consumption data directly from their installed smart meter, we designed a mechanism for capturing those data for consumer use via an open smart energy gateway (OpenSEG). By design, OpenSEG provides a clearly defined boundary for equipment and data ownership. OpenSEG is an open-source data management platform to enable better data management of smart meter data. Effectively, it is an information architecture designed to work with the ZigBee Smart Energy Profile 1.x (SEP 1.x). It was specifically designed to reduce cyber-security risks and provide secure information directly from smart meters to consumers in near real time, using display devices already owned by the consumers. OpenSEG stores 48 hours of recent consumption data in a circular cache using a format consistent with commonly available archived (not real-time) consumption data such as Green Button, which is based on the Energy Services Provider Interface (ESPI) data standard. It consists of a common XML format for energy usage information and a data exchange protocol to facilitate automated data transfer upon utility customer authorization. Included in the design is an application program interface by which users can acquire data from OpenSEG for further post processing. A sample data display application is included in the initial software product. The data display application demonstrates that OpenSEG can help electricity use data to be retrieved from a smart meter and ported to a wide variety of user-owned devices such as cell phones or a user-selected database. This system can be used for homes, multi-family buildings, or small commercial buildings in California.
Romeo, G.; Barnes, R. J.; Ukhorskiy, A. Y.; Sotirelis, T.; Stephens, G.
The Science Gateway gives single-point access to over 4.5 years of comprehensive wave and particle measurements from the Van Allen Probes NASA twin-spacecraft mission. The Gateway provides a set of visualization and data analysis tools including: HTML5-based interactive visualization of high-level data products from all instrument teams in the form of: line plots, orbital content plots, dynamical energy spectra, L-shell context plots (including two-spacecraft plotting), FFT spectra of wave data, solar wind and geomagnetic indices data, etc.; download custom multi-instrument CDF data files of selected data products; publication quality plots of digital data; combined orbit predicts for mission planning and coordination including: Van Allen Probes, MMS, THEMIS, Arase (ERG), Cluster, GOES, Geotail, FIREBIRD; magnetic footpoint calculator for coordination with LEO and ground-based assets; real-time computation and processing of empirical magnetic field models - computation of magnetic ephemeris, computation of adiabatic invariants. Van Allen Probes is the first spacecraft mission to provide a nowcast of the radiation environment in the heart of the radiation belts, where the radiation levels are the highest and most dangerous for spacecraft operations. For this purpose, all instruments continuously broadcast a subset of their science data in real time. Van Allen Probes partners with four foreign institutions who operate ground stations that receive the broadcast: Korea (KASI), the Czech republic (CAS), Argentina (CONAE), and Brazil (INPE). The SpWx broadcast is then collected at APL and delivered to the community via the Science Gateway.
Feng, Ran; Otto-Bliesner, Bette L.; Fletcher, Tamara L.; Tabor, Clay R.; Ballantyne, Ashley P.; Brady, Esther C.
Proxy reconstructions of the mid-Piacenzian warm period (mPWP, between 3.264 and 3.025 Ma) suggest terrestrial temperatures were much warmer in the northern high latitudes (55°-90°N, referred to as NHL) than present-day. Climate models participating in the Pliocene Model Intercomparison Project Phase 1 (PlioMIP1) tend to underestimate this warmth. For instance, the underestimate is ∼10 °C on average across NHL and up to 17 °C in the Canadian Arctic region in the Community Climate System Model version 4 (CCSM4). Here, we explore potential mPWP climate forcings that might contribute to this mPWP mismatch. We carry out seven experiments to assess terrestrial temperature responses to Pliocene Arctic gateway closure, variations in CO2 level, and orbital forcing at millennial time scale. To better compare the full range of simulated terrestrial temperatures with sparse proxy data, we introduce a pattern recognition technique that simplifies the model surface temperatures to a few representative patterns that can be validate with the limited terrestrial proxy data. The pattern recognition technique reveals two prominent features of simulated Pliocene surface temperature responses. First, distinctive patterns of amplified warming occur in the NHL, which can be explained by lowered surface elevation of Greenland, pattern and amount of Arctic sea ice loss, and changing strength of Atlantic meridional overturning circulation. Second, patterns of surface temperature response are similar among experiments with different forcing mechanisms. This similarity is due to strong feedbacks from responses in surface albedo and troposphere water vapor content to sea ice changes, which overwhelm distinctions in forcings from changes in insolation, CO2 forcing, and Arctic gateway closure. By comparing CCSM4 simulations with proxy records, we demonstrate that both model and proxy records show similar patterns of mPWP NHL terrestrial warmth, but the model underestimates the magnitude
Arfan Haqiqi Sulasmoro
Full Text Available Village administration is part of the central government whose operations are aimed at rural areas. Village government is led by a village head, which is in charge of organizing the government, implementing community development, and also empowering the village community. Caused by the rush of community problem, a village head must be provided quick and accurate information to handle community problem. This research aimed to build an information system integrated with an SMS gateway to help both of village head and village administration staff to tackle community problem efficiently. The information system built by web-based mail management combined with MySQL database.
Berg, Emily A.; Hanson, Mark
This chapter provides an example of how one university's institutional research office played an active role in using data from institutional studies to guide the university toward courses ripe for change, faculty toward successful teaching strategies, students toward successful learning behaviors, and the university toward assessing the impact of…
Full Text Available We update critical reviews of sites bearing hominin remains and/or tools from Europe (including the Balkans and Greece and conclude that the only compelling evidence of hominin presence in these regions was after ~0.9 Ma (million-years-ago, bracketed by the end of the Jaramillo subchron (0.99 Ma and the Brunhes-Matuyama boundary (0.78 Ma and straddling the climatic late Early Pleistocene revolution (EPR at the onset of enhanced glacial/interglacial activity that reverberated worldwide. Europe may have become initially populated during the EPR when, possibly for the first time in the Pleistocene, vast and exploitable ecosystems were generated along the Danube-Po Gateway. These newly formed settings, characterized by lowlands with open grasslands and reduced woody cover during glacial/interglacial transitions, represented the closest analogues to the savanna environment to which several large mammals linked with hominins in a common food web were adapted. It was only after stable and vast grassland-savanna environments opened that large mammals (e.g. megaherbivores could expand into Europe along the Danube-Po Gateway in conjunction with the attached food web to which hominins belonged.
Golden, Aaron; McLellan, Andrew S; Dubin, Robert A; Jing, Qiang; O Broin, Pilib; Moskowitz, David; Zhang, Zhengdong; Suzuki, Masako; Hargitai, Joseph; Calder, R Brent; Greally, John M
Massively-parallel sequencing (MPS) technologies and their diverse applications in genomics and epigenomics research have yielded enormous new insights into the physiology and pathophysiology of the human genome. The biggest hurdle remains the magnitude and diversity of the datasets generated, compromising our ability to manage, organize, process and ultimately analyse data. The Wiki-based Automated Sequence Processor (WASP), developed at the Albert Einstein College of Medicine (hereafter Einstein), uniquely manages to tightly couple the sequencing platform, the sequencing assay, sample metadata and the automated workflows deployed on a heterogeneous high performance computing cluster infrastructure that yield sequenced, quality-controlled and 'mapped' sequence data, all within the one operating environment accessible by a web-based GUI interface. WASP at Einstein processes 4-6 TB of data per week and since its production cycle commenced it has processed ~ 1 PB of data overall and has revolutionized user interactivity with these new genomic technologies, who remain blissfully unaware of the data storage, management and most importantly processing services they request. The abstraction of such computational complexity for the user in effect makes WASP an ideal middleware solution, and an appropriate basis for the development of a grid-enabled resource - the Einstein Genome Gateway - as part of the Extreme Science and Engineering Discovery Environment (XSEDE) program. In this paper we discuss the existing WASP system, its proposed middleware role, and its planned interaction with XSEDE to form the Einstein Genome Gateway.
Niezgodzki, Igor; Knorr, Gregor; Lohmann, Gerrit; Tyszka, Jarosław; Markwick, Paul J.
We investigate the impact of different CO2 levels and different subarctic gateway configurations on the surface temperatures during the latest Cretaceous using the Earth System Model COSMOS. The simulated temperatures are compared with the surface temperature reconstructions based on a recent compilation of the latest Cretaceous proxies. In our numerical experiments, the CO2 level ranges from 1 to 6 times the preindustrial (PI) CO2 level of 280 ppm. On a global scale, the most reasonable match between modeling and proxy data is obtained for the experiments with 3 to 5 × PI CO2 concentrations. However, the simulated low- (high-) latitude temperatures are too high (low) as compared to the proxy data. The moderate CO2 levels scenarios might be more realistic, if we take into account proxy data and the dead zone effect criterion. Furthermore, we test if the model-data discrepancies can be caused by too simplistic proxy-data interpretations. This is distinctly seen at high latitudes, where most proxies are biased toward summer temperatures. Additional sensitivity experiments with different ocean gateway configurations and constant CO2 level indicate only minor surface temperatures changes (greenhouse worlds is best constrained by temperatures in the midlatitudes.
Buchanan, Donald G.
This study evaluated selected demographic, pre-enrollment, and economic status variables in comparison to college-level performance factors of GPA and course completion ratios for gateway math and science courses. The Transfer and Retention of Urban Community College Students (TRUCCS) project team collected survey and enrollment data for this study in the Los Angeles Community College District (LACCD). The TRUCCS team surveyed over 5,000 students within the nine campus district beginning in the fall of 2000 and spring of 2001 with follow-up data for next several years. This study focused on the math and science courses; established background demographics; evaluated pre-enrollment high school self-reported grades; reviewed high school and college level math courses taken; investigated specific gateway courses of biology, chemistry and physics; and compared them to the overall GPAs and course completion ratios for 4,698 students. This involved the SPSS development of numerous statistical products including the data from frequency distributions, means, cross-tabulations, group statistics t-tests, independent samples t-tests, and one-way ANOVA. Findings revealed demographic and economic relationships of significance for students' performance factors of GPA and course completion ratios. Furthermore, findings revealed significant differences between the gender, age, ethnicity and economic employment relationships. Conclusions and implications for institutions of higher education were documented. Recommendations for dissemination, intervention programs, and future research were also discussed.
Kamigaki, Akane; Nito, Kazumasa; Hikino, Kazumi; Goto-Yamada, Shino; Nishimura, Mikio; Nakagawa, Tsuyoshi; Mano, Shoji
Bimolecular fluorescence complementation (BiFC) is widely used to detect protein-protein interactions, because it is technically simple, convenient, and can be adapted for use with conventional fluorescence microscopy. We previously constructed enhanced yellow fluorescent protein (EYFP)-based Gateway cloning technology-compatible vectors. In the current study, we generated new Gateway cloning technology-compatible vectors to detect BiFC-based multiple protein-protein interactions using N- and C-terminal fragments of enhanced cyan fluorescent protein (ECFP), enhanced green fluorescent protein (EGFP), and monomeric red fluorescent protein (mRFP1). Using a combination of N- and C-terminal fragments from ECFP, EGFP and EYFP, we observed a shift in the emission wavelength, enabling the simultaneous detection of multiple protein-protein interactions. Moreover, we developed these vectors as binary vectors for use in Agrobacterium infiltration and for the generate transgenic plants. We verified that the binary vectors functioned well in tobacco cells. The results demonstrate that the BiFC vectors facilitate the design of various constructions and are convenient for the detection of multiple protein-protein interactions simultaneously in plant cells.
Hikino, Kazumi; Goto-Yamada, Shino; Nishimura, Mikio; Nakagawa, Tsuyoshi; Mano, Shoji
Bimolecular fluorescence complementation (BiFC) is widely used to detect protein—protein interactions, because it is technically simple, convenient, and can be adapted for use with conventional fluorescence microscopy. We previously constructed enhanced yellow fluorescent protein (EYFP)-based Gateway cloning technology-compatible vectors. In the current study, we generated new Gateway cloning technology-compatible vectors to detect BiFC-based multiple protein—protein interactions using N- and C-terminal fragments of enhanced cyan fluorescent protein (ECFP), enhanced green fluorescent protein (EGFP), and monomeric red fluorescent protein (mRFP1). Using a combination of N- and C-terminal fragments from ECFP, EGFP and EYFP, we observed a shift in the emission wavelength, enabling the simultaneous detection of multiple protein—protein interactions. Moreover, we developed these vectors as binary vectors for use in Agrobacterium infiltration and for the generate transgenic plants. We verified that the binary vectors functioned well in tobacco cells. The results demonstrate that the BiFC vectors facilitate the design of various constructions and are convenient for the detection of multiple protein—protein interactions simultaneously in plant cells. PMID:27490375
Gagoski, Dejan; Mureev, Sergey; Giles, Nichole; Johnston, Wayne; Dahmer-Heath, Mareike; Škalamera, Dubravka; Gonda, Thomas J; Alexandrov, Kirill
Although numerous techniques for protein expression and production are available the pace of genome sequencing outstrips our ability to analyze the encoded proteins. To address this bottleneck, we have established a system for parallelized cloning, DNA production and cell-free expression of large numbers of proteins. This system is based on a suite of pCellFree Gateway destination vectors that utilize a Species Independent Translation Initiation Sequence (SITS) that mediates recombinant protein expression in any in vitro translation system. These vectors introduce C or N terminal EGFP and mCherry fluorescent and affinity tags, enabling direct analysis and purification of the expressed proteins. To maximize throughput and minimize the cost of protein production we combined Gateway cloning with Rolling Circle DNA Amplification. We demonstrate that as little as 0.1 ng of plasmid DNA is sufficient for template amplification and production of recombinant human protein in Leishmania tarentolae and Escherichia coli cell-free expression systems. Our experiments indicate that this approach can be applied to large gene libraries as it can be reliably performed in multi-well plates. The resulting protein expression pipeline provides a valuable new tool for applications of the post genomic era. Copyright © 2014 Elsevier B.V. All rights reserved.
Maumbe, Blessing Mukabeta; Owei, Vesper; Alexander, Helen
The paper examines e-government development in Africa. This study is based on the Cape Gateway project in South Africa, a leading e-government initiative on the continent. We observe that African countries have jumped on the e-government band wagon by looking mostly at the benefits without a clear risk assessment. We argue that African countries…
Davis, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wilkerson, Andrea M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Samla, Connie [Sacramento Municipal Utility District, Sacramento, CA (United States); Bisbee, Dave [Sacramento Municipal Utility District, Sacramento, CA (United States)
The GATEWAY program documented the performance of tunable-white LED lighting systems installed in several spaces within the ACC Care Center, a senior-care facility in Sacramento, CA. The project results included energy savings and improved lighting quality, as well as other possible health-related benefits that may have been attributable, at least in part, to the lighting changes.
Deri, Melissa A.; Mills, Pamela; McGregor, Donna
A flipped classroom is one where students are first introduced to content outside of the classroom. This frees up class time for more active learning strategies and has been shown to enhance student learning in high school and college classrooms. However, many studies in General Chemistry, a college gateway science course, were conducted in small…
Liu, H; Gu, D; Sheng, L; Wang, Q; Zhang, Y
The aims of this study were to create and evaluate the Gateway-compatible plasmids for investigating the function of genes in Vibrio alginolyticus and other Gram-negative bacteria. In this study, Gateway-compatible plasmids were successfully constructed for rapid and comprehensive function analysis of genes. Taking advantage of these plasmids, the in-frame deletion mutant strains and their complemented strains of five T6SS genes, including dotU1, VEPGS_0008, VEPGS_0011, hcp2 and ppkA2, were obtained. The results illustrated that all the mutant strains showed no significant effects on extracellular protease production, expression of Hcp1, and biofilm formation when compared to the wild-type strain, but in-frame deletion of VEPGS_0008 resulted in obvious biofilm reduction and the complemented strain restored to the level of the wild-type strain. Besides, in-frame deletion of dotU1, VEPGS_0008 and ppkA2 abolished the swarming ability. A set of Gateway-compatible vectors for internal insertion, in-frame deletion and complementation of the target genes is constructed to facilitate the general and rapid function analysis of genes involved in T6SS in Vibrio alginolyticus. The modified Gateway-compatible plasmids greatly facilitate the high-throughput and convenient function analysis of the unidentified genes. No claim to Chinese Government works. Letters in Applied Microbiology © 2012 The Society for Applied Microbiology.
Avramopoulos, Hercules; Katopodis, V.; Groumas, P.
Within PANTHER research project, we aim to develop multi-rate, multi-format, multi-reach and multi-flow terabit transceivers for data-center gateways, having the capability of flexibly controlling this enormous capacity and distributing it among independent optical flows. To this end, we combine...
The GATEWAY program evaluated a trial installation of tunable-white LED lighting systems in three classrooms in the Carrollton-Farmers Branch Independent School District in Carrollton, TX. The report provides valuable insights into the use of this technology in a real-world setting.
Summary of GATEWAY report evaluating a trial installation of tunable-white LED lighting systems in three classrooms in the Carrollton-Farmers Branch Independent School District in Carrollton, TX. The report provides valuable insights into the use of this technology in a real-world setting.
... and regulations for the Morley Nelson Snake River Birds of Prey National Conservation Area, the BLM... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLWY920000/51010000.ER0000/LVRWK09K0990/241A; WYW-174598; IDI-35849] Notice of Availability of the Record of Decision for the Gateway West 230/345...
Maggio, Lauren A; Willinsky, John M; Steinberg, Ryan M; Mietchen, Daniel; Wass, Joseph L; Dong, Ting
Wikipedia is a gateway to knowledge. However, the extent to which this gateway ends at Wikipedia or continues via supporting citations is unknown. Wikipedia's gateway functionality has implications for information design and education, notably in medicine. This study aims to establish benchmarks for the relative distribution and referral (click) rate of citations-as indicated by presence of a Digital Object Identifier (DOI)-from Wikipedia, with a focus on medical citations. DOIs referred from the English Wikipedia in August 2016 were obtained from Crossref.org. Next, based on a DOI's presence on a WikiProject Medicine page, all DOIs in Wikipedia were categorized as medical (WP:MED) or non-medical (non-WP:MED). Using this categorization, referred DOIs were classified as WP:MED, non-WP:MED, or BOTH, meaning the DOI may have been referred from either category. Data were analyzed using descriptive and inferential statistics. Out of 5.2 million Wikipedia pages, 4.42% (n = 229,857) included at least one DOI. 68,870 were identified as WP:MED, with 22.14% (n = 15,250) featuring one or more DOIs. WP:MED pages featured on average 8.88 DOI citations per page, whereas non-WP:MED pages had on average 4.28 DOI citations. For DOIs only on WP:MED pages, a DOI was referred every 2,283 pageviews and for non-WP:MED pages every 2,467 pageviews. DOIs from BOTH pages accounted for 12% (n = 58,475). The referral of DOI citations found in BOTH could not be assigned to WP:MED or non-WP:MED, as the page from which the referral was made was not provided with the data. While these results cannot provide evidence of greater citation referral from WP:MED than non-WP:MED, they do provide benchmarks to assess strategies for changing referral patterns. These changes might include editors adopting new methods for designing and presenting citations or the introduction of teaching strategies that address the value of consulting citations as a tool for extending learning.
Lauren A Maggio
Full Text Available Wikipedia is a gateway to knowledge. However, the extent to which this gateway ends at Wikipedia or continues via supporting citations is unknown. Wikipedia's gateway functionality has implications for information design and education, notably in medicine. This study aims to establish benchmarks for the relative distribution and referral (click rate of citations-as indicated by presence of a Digital Object Identifier (DOI-from Wikipedia, with a focus on medical citations. DOIs referred from the English Wikipedia in August 2016 were obtained from Crossref.org. Next, based on a DOI's presence on a WikiProject Medicine page, all DOIs in Wikipedia were categorized as medical (WP:MED or non-medical (non-WP:MED. Using this categorization, referred DOIs were classified as WP:MED, non-WP:MED, or BOTH, meaning the DOI may have been referred from either category. Data were analyzed using descriptive and inferential statistics. Out of 5.2 million Wikipedia pages, 4.42% (n = 229,857 included at least one DOI. 68,870 were identified as WP:MED, with 22.14% (n = 15,250 featuring one or more DOIs. WP:MED pages featured on average 8.88 DOI citations per page, whereas non-WP:MED pages had on average 4.28 DOI citations. For DOIs only on WP:MED pages, a DOI was referred every 2,283 pageviews and for non-WP:MED pages every 2,467 pageviews. DOIs from BOTH pages accounted for 12% (n = 58,475. The referral of DOI citations found in BOTH could not be assigned to WP:MED or non-WP:MED, as the page from which the referral was made was not provided with the data. While these results cannot provide evidence of greater citation referral from WP:MED than non-WP:MED, they do provide benchmarks to assess strategies for changing referral patterns. These changes might include editors adopting new methods for designing and presenting citations or the introduction of teaching strategies that address the value of consulting citations as a tool for extending learning.
Exon, N. F.
A fairly complete Maastrichtian to Holocene marine sequence 776 m thick was drilled at ODP Site 1172 on the East Tasman Plateau. The ETP is a continental fragment that rifted from the adjacent parts of Gondwana (Tasmania, South Tasman Rise and Lord Howe Rise) in the Late Cretaceous and became part of the southwest margin of the proto-Pacific. However, rapid subsidence started only in the late Eocene. The ETP lies just east of the Tasmanian Gateway that formed as Australia and Antarctica separated in the Paleogene, so Site 1172 was ideally located to monitor the effects of its opening. Slow detrital sedimentation (averaging 1.3 cm/ka) persisted until the latest Eocene in this area east of the subsiding `land bridge' (Tasmania and the South Tasman Rise) connecting Australia and Antarctica. When the South Tasman Rise separated from Antarctica at the Eocene-Oligocene boundary (33.5 Ma), the Tasmanian Gateway opened, currents first connected the Indian and Pacific Oceans, and pelagic carbonate sedimentation commenced. At Site 1172, dinocysts, spores and pollen dominate the Maastrichtian through middle Eocene microfossil assemblages, diatoms become abundant in the middle Eocene, and calcareous nannofossils and planktonic foraminifers dominate the Oligocene. The sequences provide evidence of a complex interplay of tectonics, paleoceanography including the onset of the Antarctic Circumpolar Current, and Antarctic cooling and glaciation. The ETP moved northward with Australia, from 65§S in the Late Cretaceous to 60§S in the early Oligocene. At Site 1172, during the Maastrichtian and Paleocene (70-55 Ma) shallow marine mudstone was deposited in reducing conditions, while the onshore climate was humid and seasonally cool and supported a conifer forest. Much of the Paleocene is missing. Cool oceanic conditions characterised the Eocene (dinocysts represent the `Transantarctic Flora'). The early and middle Eocene (55-37 Ma) was marked by slow subsidence, a thick sequence of
Full Text Available Despite its “metodologia non-grata” status in language teaching, translation has a lot to offer in the second language classroom. This article argues that a reconsideration of pertinent concepts, such as the source and product of the translation, as well as a post-method rather than an exclusivist approach to language teaching, can provide a gateway to re-introducing translation in the EFL/ESL curriculum. Through a series of activities based on Neil Gaiman’s Coraline, it also makes a case for the teacher’s role in motivating the student as the key to using translation in teaching a foreign or second language.
Don, Emily K; Formella, Isabel; Badrock, Andrew P; Hall, Thomas E; Morsch, Marco; Hortle, Elinor; Hogan, Alison; Chow, Sharron; Gwee, Serene S L; Stoddart, Jack J; Nicholson, Garth; Chung, Roger; Cole, Nicholas J
Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.
Kagale, Sateesh; Uzuhashi, Shihomi; Wigness, Merek; Bender, Tricia; Yang, Wen; Borhan, M. Hossein; Rozwadowski, Kevin
Plant viral expression vectors are advantageous for high-throughput functional characterization studies of genes due to their capability for rapid, high-level transient expression of proteins. We have constructed a series of tobacco mosaic virus (TMV) based vectors that are compatible with Gateway technology to enable rapid assembly of expression constructs and exploitation of ORFeome collections. In addition to the potential of producing recombinant protein at grams per kilogram FW of leaf tissue, these vectors facilitate either N- or C-terminal fusions to a broad series of epitope tag(s) and fluorescent proteins. We demonstrate the utility of these vectors in affinity purification, immunodetection and subcellular localisation studies. We also apply the vectors to characterize protein-protein interactions and demonstrate their utility in screening plant pathogen effectors. Given its broad utility in defining protein properties, this vector series will serve as a useful resource to expedite gene characterization efforts. PMID:23166857
van der Boon, A.; Beniest, A.; Ciurej, A.; Gaździcka, E.; Grothe, A.; Sachsenhofer, R. F.; Langereis, C. G.; Krijgsman, W.
During the Eocene-Oligocene transition (EOT), a major palaeoenvironmental change took place in the Paratethys Sea of central Eurasia. Restricted connectivity and increased stratification resulted in wide-spread deposition of organic-rich sediments which nowadays make up important hydrocarbon source rocks. The North Alpine Foreland Basin (NAFB) was a major gateway of the Paratethys Sea to the open ocean during the Eocene, but the age of closure of this gateway is still uncertain. The Ammer section in southern Germany documents the shallowing of this connection and subsequent disappearance of marine environments in the NAFB, as reflected in its sedimentary succession of turbidites to marls (Deutenhausen to Tonmergel beds), via coastal sediments (Baustein beds) to continental conglomerates (Weißach beds). Here, we apply organic geochemistry and date the lithological transitions in the Ammer section using integrated stratigraphy, including magnetostratigraphy and biostratigraphy. Nannoplankton and dinocyst results can be reconciled when dinoflagellate species Wetzeliella symmetrica is of late Eocene age. Our magnetostratigraphy then records C13r-C13n-C12r and allows calculation of sediment accumulation rates and estimation of ages of lithological transitions. We show that the shallowing from turbiditic slope deposits (Deutenhausen beds) to shelf sediments (Tonmergel beds) coincides with the Eocene-Oligocene boundary at 33.9 Ma. The transition to continental sediments is dated at ca. 33.15 Ma, significantly older than suggested by previous studies. We conclude that the transition from marine to continental sediments drastically reduced the marine connection through the western part of the NAFB and influenced the oxygen conditions of the Paratethys Sea.
Kaiser, D.; Palanisamy, G.; Santhana Vannan, S.; Wei, Y.; Smith, T.; Starke, M.; Wibking, M.; Pan, Y.; Devarakonda, Ranjeet; Wilson, B. E.; Wind Energy Data; Information (WENDI) Gateway Team
In support of the U.S. Department of Energy’s (DOE) Energy Efficiency and Renewable Energy (EERE) Office, DOE's Oak Ridge National Laboratory (ORNL) has launched the Wind ENergy Data & Information (WENDI) Gateway. The WENDI Gateway is intended to serve a broad range of wind-energy stakeholders by providing easy access to a large amount of wind energy-related data and information through its two main interfaces: the Wind Energy Metadata Clearinghouse and the Wind Energy Geographic Information System (WindGIS). The Metadata Clearinghouse is a powerful, customized search tool for discovering, accessing, and sharing wind energy-related data and information. Its database of metadata records points users to a diverse array of wind energy-related resources: from technical and scientific journal articles to mass media news stories; from annual government and industry reports to downloadable datasets, and much more. Through the WindGIS, users can simultaneously visualize a wide spectrum of United States wind energy-related spatial data, including wind energy power plant locations; wind resource maps; state-level installed wind capacity, generation, and renewable portfolio standards; electric transmission lines; transportation infrastructure; interconnection standards; land ownership, designation, and usage; and various ecological data layers. In addition, WindGIS allows users to download much of the data behind the layers. References:  Devarakonda R., et al. Mercury: reusable metadata management, data discovery and access system. Earth Science Informatics (2010), 3(1): 87-94.  Wilson, Bruce E., et al. "Mercury Toolset for Spatiotemporal Metadata." (2010).
William T. Lin
Full Text Available In a residential or nursing home environment, using ZigBee/802.15.4 wireless network specifically to collect and gather various types of personal health data proves to be a feasible choice. The Continua Guidelines has defined both the sensor-LAN IF (sensor Local Area Network Interface PHD (Personal Health Device and PAN IF (Personal Area Network Interface PHD, but only a Continua certified sensor-LAN IF PHD with Zigbee HC (Health Care profile can connect with Continua AHD (Application Hosting Device through Zigbee/802.15.4 network and allows data communicating between AHD and PHDs. In this paper, we present a distributed Continua AHD system design that divides the AHD device containing Continua PAN IF into Continua AHD Host and Continua AHD Gateway with communication through ZigBee/802.15.4 network. Under this structure, a Continua PHD connects with a Continua AHD Host through Continua AHD Gateway within ZigBee/802.15.4 network. One immediate advantage of the proposed system is that both of the Continua sensor-LAN IF and PAN IF PHDs can connect with Continua AHD (Host through ZigBee/802.15.4 network. To further address the QoS (Quality of Service issue for Continua PAN IF message transmission in a ZigBee network, we present a software approach to automatically determine the types of packet transmitted and execute Continua QoS control. Together with the QoS mechanism in the enhanced ZigBee MAC Layer, this approach realizes a complete Continua QoS control mechanism for the distributed AHD system.
Development of unconventional fossil fuels is generating controversy in North America, where citizen support or opposition can shape political decisions. This study explores the role of values in citizen perceptions. The case study is Canada's proposed Northern Gateway Pipeline (NGP), which would transport bitumen from Alberta's oil sands to British Columbia's (BC) northern coast for export. Data were collected in 2013 from a sample of Canadian citizens (n=2628). The survey instrument elicited citizen perceptions of the NGP, as well as values and attitudes. Respondents in the Alberta subsample are the most likely to support the NGP and to perceive economic benefits. Respondents in the BC subsample are the most likely to oppose the NGP and to perceive environmental risks. To explore heterogeneity in motivations among both subsamples, respondent clusters are constructed based on values. In both regions, opposition is highest in clusters with strong biospheric–altruistic values, while acceptance is highest in clusters with strong traditional values. Regional effects are also substantial; NGP acceptance is higher in each of Alberta's clusters relative to equivalent clusters in BC. Regional context seems to shape how values correspond with perceptions. Insights are drawn for energy project development, public consultation and energy planning. - Highlights: • Acceptance of the proposed Northern Gateway Pipeline (NGP) varies by region. • Regional variations in perceptions correspond with differing risks and benefits. • Opposition is highest among citizens with strong biospheric–altruistic values. • Acceptance is highest for citizens with strong traditional or egoistic values. • Values may shape citizen perceptions of economic benefits and environmental risks
Otten, Roy; Mun, Chung Jung; Dishion, Thomas J
There is limited empirical integration between peer clustering theory and the Gateway framework. The goal of the present study was to test the hypothesis that friendship associations partly predict gateway escalations in the use of drugs from adolescence to adulthood. This longitudinal study analyzed 3 waves of data from a community sample of 711 male and female participants without a history of illicit drug use reporting drug use at age 17, 22, and 27. Substance use assessments including tobacco, alcohol, cannabis, onset and abuse/dependence tendency of illicit drugs other than cannabis (i.e., cocaine, methamphetamine, and opiates), and friends' reported use of illicit drugs. Structural equation modeling was used to test the hypothesized model. Participants' cannabis use level at age 17 was positively associated with perceived friends' drug use at age 22, which in turn predicted participants' onset of illicit drug use between ages 22 and 27. Moreover, progression of tobacco use throughout age 17 to 22 was associated with an increased onset of illicit drug use between ages 22 and 27. Apart for an effect of cannabis use at age 22 on abuse and dependence tendency to various drugs at age 28, results were similar. During this period of development, the availability and selection of drug-using friends contributes to the progression to potentially more rewarding and damaging illicit drugs. These findings suggest the need to attend to the peer ecology in prevention and support the common practice of using abstaining peers in treatment for drug dependence. Copyright © 2017. Published by Elsevier Ltd.
Full Text Available Teknologi informasi merupakan sebuah kebutuhan manusia yang sangat penting, karena kemajuan zaman segala aktivitas kerja sebagian besar dibantu oleh teknologi informasi. Toko PetZone merupakan salah satu jenis usaha Petshop yang melayani penitipan dan perawatan hewan. Proses bisnis yang dilakukan Toko PetZone masih dilakukan dengan manual seperti contoh pencatatan data-data pelanggan maka kemajuan bisnis yang terjadi menyebabkan timbulnya kebutuhan sistem informasi yang dapat melakukan pencatatan layanan Pethotel, Pethospital, Jadwal kontrol hewan, Petgrooming dan monitoring keadaan hewan. Pengembangan sistem informasi lainnya ialah selain dapat melakukan pencatatan dapat memberikan informasi keadaan atau status hewan yang dititipkan melalui pesan singkat (SMS Gateway sebagai alternatif baru untuk meningkatkan kepercayaan pelangan kepada Toko PetZone. Maka dari itu penelitian pembangunan aplikasi ini dibuat. Tahapan dalam pembuatan aplikasi ini menggunakan beberapa tahap yaitu studi pustaka, observasi dan bimbingan. Metode yang digunakan dalam perancangan ialah metode waterfall. Metode ini sangat tepat dalam pembuatan aplikasi seperti ini, karena mempunyai alur yang memungkinkan perancangan untuk mengevaluasi aplikasi tanpa harus mengubah dari dasar. Aplikasi sistem penitipan dan perawatan hewan dibangun dengan menggunakan bahasa pemograman Java dan mesin database yang digunakan untuk menyimpan data-data menggunakan MySql Server. Antarmuka aplikasi sistem dibuat dengan GUI Interface yang memanfaatkan librari Java yaitu Java swing. Hasil akhir dari penelitian ialah sebuah aplikasi dekstop yang dapat mencatat layananlayanan yang diberikan Toko PetZone dan meningkatkan kinerja Toko Petzone dan selain itu memberikan alternatif baru untuk meningkatkan kepercayaan pelanggan terhadap Toko Petzone melalui fasilitas monitoring hewan titipan dengan menggunakan pesan singkat (SMS Gateway.
Wang Ziliang; Li Tianxiao; Li Zhaoshuo; Xue Jiangyu; Bai Weixing; Li Li; Zhai Shuiting; Cao Huicun; Shi Shuaitao
Objective: To assess the safety, feasibility and short-mid term effectiveness of the Wingspan stent in the treatment of high-grade symptomatic intracranial atheromatous stenosis. Methods: Sixty-three patients with symptomatic intracranial atheromatous stenosis (≥70%) were treated with the Gateway balloon-Wingspan stent system. The pre-and post-treatment improvement of symptoms, severity of stenosis, successful rate of treatment, complications were evaluated. Physician-reported follow-up in all 63 patients lasted an average period of 9.3 months. The χ 2 test was used for statistics. Results: Sixty-three lesions involved the intracranial internal carotid artery (n=12), middle cerebral artery (n=22), V4 segment vertebral artery (n=15), basilar artery (n=14). Sixty-two lesions were successfully treated with the deployment of the self-expanding Wingspan stent with residual stenosis ≤30%. One case failed because of intracranial hemorrhage during the operation. The successful rate of stenting is 98.0% (62/63). The mean stenosis was (82.3 ± 9.2)% before treatment, and it improved to (23.0 ± 11.2)% after stent placement. During the follow-up period, 1 patient died of postprocedural hyper-perfusion, one had ischemic stroke after procedure, one presented Homer syndrome at the 11th day, one had ischemic stroke at the 5th month after the procedure, while the other patients had significantly improved. The frequency of ≥50% restenosis on follow-up angiography or computed tomography was 10% (1/10). Conclusions: Angioplasty and stenting for high-grade symptomatic intracranial artery stenosis with the Gateway-Wingspan stent system are safe and effective with high rate of technical success, but moderately high rate of residual stenosis and restenosis exist. With the improvement of operation skill and stent system, a better outcome in the future could be achieved. (authors)
Inter-University Council for Higher Education Overseas, London (England).
The following articles and reports are presented in this publication of "Overseas Universities:""Appropriate Technology and University Education," by John Twidell; "The Training of Engineering Staff for Higher Education Institutions in Developing Countries," by D. W. Daniel, C. A. Leal, J. H. Maynes and T. Wilmore;…
Grindsted, Thomas Skou
, has put a counter pressure on the university, forcing it to review its role as a driver for sustainable development. Today, universities and intergovernmental institutions have developed more than 31 SHE declarations, and more than 1400 universities have signed a SHE declaration globally. However....... Declarations tend to have impact on three trends. Firstly, there is emerging international consensus on the university’s role and function in relation to sustainable development; secondly, the emergence of national legislation, and thirdly, an emerging international competition to be leader in sustainable......Declarations on Sustainability in Higher Education (SHE) can be viewed as a piece of international regulation. Over the past 30 years research at universities has produced convincing data to warn about deterioration of the environment, resource scarcity and the need for sustainability. This in turn...
US Agency for International Development — USAID University is USAID's learning management system. Features include 1) Access online courses 2) Register for instructor-led courses 3)Access your student...
Carlson, Eric; Wald, Robert
Presents a guide to be used by students and teachers in conjunction with a television program about Einstein. Provides general information about special and general relativity, and the universe. Includes questions for discussion after each section and a bibliography. (MA)
This report describes the performance of a two year grant to provide partial funding for an engineering/science/mathematics program at the University of Wisconsin, Milwaukee. This program serves middle and high school students in a summer program coupled with academic year activities, and is designed to attract underrepresented students into these disciplines. The UWM program has been running since 1974.
American Journal of Play, 2010
Jaak Panksepp, known best for his work on animal emotions and coining the term "affective neuroscience," investigates the primary processes of brain and mind that enable and drive emotion. As an undergraduate, he briefly considered a career in electrical engineering but turned instead to psychology, which led to a 1969 University of…
Barenboim, Gabriela; /Valencia U.; Mena, Olga; Quigg, Chris; /Fermilab
If the equation of state for ''dark energy'' varies periodically, the expansion of the Universe may have undergone alternating eras of acceleration and deceleration. We examine a specific form that survives existing observational tests, does not single out the present state of the Universe as exceptional, and suggests a future much like the matter-dominated past: a smooth expansion without a final inflationary epoch.
Function: Monitor global change and thunderstorm processes through observations of Earth's high-latitude lightning. This instrument will combine long-lived sampling of individual thunderstorms with long-term observations of lightning at high latitudes: How is global change affecting thunderstorm patterns; How do high-latitude thunderstorms differ from low-latitude? Why is the Gateway the optimal facility for this instrument / research: Expected DSG (Deep Space Gateway) orbits will provide nearly continuous viewing of the Earth's high latitudes (50 degrees latitude and poleward); These regions are not well covered by existing lightning mappers (e.g., Lightning Imaging Sensor / LIS, or Geostationary Lightning Mapper / GLM); Polar, Molniya, Tundra, etc. Earth orbits have significant drawbacks related to continuous coverage and/or stable FOVs (Fields of View).
Barjau Estevan, Carlos Salvador
Este proyecto detalla la implementación a nivel Software de una plataforma de encapsulación del estándar de difusión de vídeo DVB-T2. Barjau Estevan, CS. (2013). Diseño, Desarrollo y Validación de un Gateway-T2 y un Analizador T2-MI. http://hdl.handle.net/10251/33008. Archivo delegado
Brierley, Chris M.; Fedorov, Alexey V.
Changes in inter-ocean gateways caused by tectonic processes have been long considered an important factor in climate evolution on geological timescales. Three major gateway changes that occurred during the Late Miocene and Pliocene epochs are the closing of the Central American Seaway (CAS) by the uplift of the Isthmus of Panama, the opening of the Bering Strait, and the closing of a deep channel between New Guinea and the Equator. This study compares the global climatic effects of these changes within the same climate model framework. We find that the closure of the CAS and the opening of the Bering Strait induce the strongest effects on the Atlantic meridional overturning circulation (AMOC). However, these effects potentially compensate, as the closure of the CAS and the opening of the Bering Strait cause similar AMOC changes of around 2 Sv (strengthening and weakening respectively). Previous simulations with an open CAS consistently simulated colder oceanic conditions in the Northern Hemisphere - contrasting with the evidence for warmer sea surface temperatures 10-3 million years ago. Here we argue that this cooling is overestimated because (a) the models typically simulated too strong an AMOC change not yet in equilibrium, (b) used a channel too deep and (c) lacked the compensating effect of the closed Bering Strait - a factor frequently ignored despite its potential influence on northern high latitudes and ice-sheet growth. Further, we discuss how these gateway changes affect various climatic variables from surface temperature and precipitation to ENSO characteristics.
Dunne, Eugene M; Hearn, Lauren E; Rose, Jonathan J; Latimer, William W
The primary aims of the present study were to assess ADHD history as a risk factor for earlier initiation and current use of licit and illicit substances among a sample of drug using adults. It was hypothesized that ADHD history would accelerate the Gateway Theory of drug use. Participants included 941 drug-using African American and Caucasian individuals in Baltimore, Maryland. The sample consisted of 124 (13.2%) participants who reported a history of ADHD and 817 (86.8%) who reported no history of ADHD. The accelerated gateway hypothesis was supported, as a history of self-reported ADHD was significantly associated with younger ages of initiation for alcohol, cigarettes, marijuana, and cocaine use. Participants with a history of ADHD were also more likely to engage in recent HIV-risk behavior, such as injection drug use and needle sharing. This study provides compelling data in support of an accelerated gateway model for substance use related to ADHD history and increased problem severity in adulthood. Targeted substance use prevention and intervention may be beneficial for those with ADHD. Copyright © 2014 Elsevier Ltd. All rights reserved.
Eliana Consoni Rossi
Full Text Available Este estudio muestra cómo los principales bancos en operación en Brasil, durante el 2003, aplican las dos prácticas de la globalízación -concentración y dispersión- en el ambiente urbano brasileño. Cuatro estrategias globales de localízación de estos bancos y dos domésticas fueron identificadas. Las seis estrategias resultan de la aplicación de uno de los métodos de análisis multivariado, el análisis de componentes principales, en una matriz compuesta por 54 ciudades y 31 bancos. Consideradas las funciones de la ciudad mundial, se adoptó el concepto de gateway city, de Alan Pred, para interpretar las respectivas estrategias. La hinterland de la ciudad mundial fue entendida como sus enlaces funcionales con otras ciudades del país, creados en la economía global por los productores de servicios con alto valor agregado, ubicados en la ciudad mundial. Los resultados revelan que San Pablo articula las economías nacional y global como gateway city y que Curitiba emerge como una alternativa a San Pablo en esta función. Además, muestran que la producción en ventas de importantes ciudades de la red urbana brasileña poco contribuye para el desempeño de estas urbes en el contexto globafizado de los bancosThis exploratory study shows how the major hanks operating in Brazil in 2003 apply the two global practices - concentration and dispersion - in the Brazilian urban environment. Four global and two domestic location strategies of those banks were identified. The strategies were found employing the multivariate method of principal component analysis in a matrix of 54 cities versus 31 banks. In the light of world city functions, the gateway city concept as defined by Alan Pred was the basis for interpreting the six bank location strategies. The hinterland of a world city was understood as its functional links to other cities in the country, created in the global economy by advanced producer services in the world city. According to the
Siligato, Riccardo; Wang, Xin; Yadav, Shri Ram; Lehesranta, Satu; Ma, Guojie; Ursache, Robertas; Sevilem, Iris; Zhang, Jing; Gorte, Maartje; Prasad, Kalika; Heidstra, Renze
A powerful method to study gene function is expression or overexpression in an inducible, cell type-specific system followed by observation of consequent phenotypic changes and visualization of linked reporters in the target tissue. Multiple inducible gene overexpression systems have been developed for plants, but very few of these combine plant selection markers, control of expression domains, access to multiple promoters and protein fusion reporters, chemical induction, and high-throughput cloning capabilities. Here, we introduce a MultiSite Gateway-compatible inducible system for Arabidopsis (Arabidopsis thaliana) plants that provides the capability to generate such constructs in a single cloning step. The system is based on the tightly controlled, estrogen-inducible XVE system. We demonstrate that the transformants generated with this system exhibit the expected cell type-specific expression, similar to what is observed with constitutively expressed native promoters. With this new system, cloning of inducible constructs is no longer limited to a few special cases but can be used as a standard approach when gene function is studied. In addition, we present a set of entry clones consisting of histochemical and fluorescent reporter variants designed for gene and promoter expression studies. PMID:26644504
Fazli, Mustafa; Harrison, Joe J.; Gambino, Michela; Givskov, Michael
Burkholderia cenocepacia is an emerging opportunistic pathogen causing life-threatening infections in immunocompromised individuals and in patients with cystic fibrosis, which are often difficult, if not impossible, to treat. Understanding the genetic basis of virulence in this emerging pathogen is important for the development of novel treatment regimes. Generation of deletion mutations in genes predicted to encode virulence determinants is fundamental to investigating the mechanisms of pathogenesis. However, there is a lack of appropriate selectable and counterselectable markers for use in B. cenocepacia, making its genetic manipulation problematic. Here we describe a Gateway-compatible allelic exchange system based on the counterselectable pheS gene and the I-SceI homing endonuclease. This system provides efficiency in cloning homology regions of target genes and allows the generation of precise and unmarked gene deletions in B. cenocepacia. As a proof of concept, we demonstrate its utility by deleting the Bcam1349 gene, encoding a cyclic di-GMP (c-di-GMP)-responsive regulator protein important for biofilm formation. PMID:25795676
The impact of science and technology on our daily lives is easily demonstrated. From new drug discoveries, to new and more efficient energy sources, to the incorporation of new technologies into business and industry, the productive applications of R and D are innumerable. The possibility of creating such applications depends most heavily on the availability of one resource: knowledge. Knowledge must be shared for scientific progress to occur. In the past, the ability to share knowledge electronically has been limited by the 'deep Web' nature of scientific databases and the lack of technology to simultaneously search disparate and decentralized information collections. U.S. science agencies invest billions of dollars each year on basic and applied research and development projects. To make the collective knowledge from this R and D more easily accessible and searchable, 12 science agencies collaborated to develop Science.gov - a single, searchable gateway to the deep Web knowledge of U.S. science agencies. This paper will describe Science.gov and its contribution to nuclear knowledge management. (author)
Susan E. Saxton
Full Text Available The aim of this article is to present the International Baccalaureate (IB Programme and briefly outline its core components, followed by a review of what authoritative reports identify as skills for the future, esteemed by universities and the job market. There is a striking match between these skills and IB outcomes; thus, DP graduates perform well in higher education and add to the reputation of those institutions. After a review of the literature, the authors found the IB Diploma Programme has been studied in many countries by both consultants and educational agencies, and also by a wide array of universities themselves; however, there are fewer qualitative studies concerning the degree to which IB graduates display attitudes, values, and behaviours in line with the IB Learner Profile. This is why the authors stress the claims made are supported by examples of significant research, noting that there is a dearth of qualitative longitudinal studies to sufficiently substantiate the affective domain claims that currently rely more on anecdotal evidence. The authors conclude by pointing out more research is needed in order to substantiate anecdotal evidence regarding future employment success for IB Diploma Programme graduates. DOI: 10.18870/hlrc.v4i3.123
Miguel Zabalza Beraza
Full Text Available Writing in the University is a basic necessity and a long-range educational purpose. One of the basic characteristics of the university context is that it requires writing both as a tool of communication and as a source of intellectual stimulation. After establishing the basic features of academic writing, this article analyzes the role of writing for students (writing to learn and for teachers (write to plan, to reflect, to document what has been done. The article also discusses the contributions of writing for both students and teachers together: writing to investigate. Finally, going beyond what writing is as academic tool, we conclude with a more playful and creative position: writing for pleasure and enjoyment.
University Physics provides an authoritative treatment of physics. This book discusses the linear motion with constant acceleration; addition and subtraction of vectors; uniform circular motion and simple harmonic motion; and electrostatic energy of a charged capacitor. The behavior of materials in a non-uniform magnetic field; application of Kirchhoff's junction rule; Lorentz transformations; and Bernoulli's equation are also deliberated. This text likewise covers the speed of electromagnetic waves; origins of quantum physics; neutron activation analysis; and interference of light. This publi
Tolonen, E.; Malmgren, M.
Free access to INIS database was opened to all the Internet users around the world on May, 2009. The article reviews the history of INIS (the International Nuclear Information System), data aquisition process, database content and search possibilities. INIS is focused on the worldwide literature of the peaceful uses of nuclear energy and the database is produced in close collaboration with the IEA/ETDE World Energy Base (ETDEWEB), a database focusing on all aspects of energy. Nuclear Science Abstracts database (NSA), which is a comprehensive collection of international nuclear science and technology literature for the period 1948 through 1976, is also briefly discussed in the article. In Finland, the recently formed Aalto University is responsible for collecting and disseminating information (literature) and for the preparation of input to the INIS and IEA/ETDE Databases on the national level
Full Text Available The board game hobby has rapidly grown and evolved in recent years, but most of the non-digital games lack tips and tutorials and remain difficult to learn and teach effectively. In this project, we integrated a popular hobbyist approach to teaching modern strategy games with classical experiential learning elements (i.e., demonstration, observation, reflection, discussion and repeated experiences. We tested our model by teaching two modern board games to Japanese high school and university students. Questionnaires, gameplay data, self-ratings and discussions showed improved understanding and enjoyment, more strategic play and more interest in modern board games over the course of the instructional sequence. The model's repetition (the participants played each game three times was rated the most useful in terms of learning the games. Overall, the integrated model was largely successful in teaching strategy board games to new players, and we offer several recommendations for teachers, designers and researchers of board games.
Richman, Barbara T.
In the past year, an increasing number of individual academic institutions have lobbied in Congress for new science facilities funds thus circumventing the traditional peer review process of evaluating the merits of such facilities. As an attempt to stem this rising tide, the National Academy of Sciences (NAS) governing council and the Association of American Universities (AAU) recently and independently issued strong statements condemning lobbying by individual universities and enthusiastically supporting the peer review system.“Informed peer judgments on the scientific merits of specific proposals, in open competition, should be a central element in the awarding of all federal funds for science,” the NAS resolution stated. AAU, meanwhile, implored “scientists, leaders of America's universities, and members of Congress” to “refrain from actions that would make scientific decisions a test of political influence rather than a judgment on the quality of the work to be done.” Roughly 50 research institutions constitute AAU; the two AAU Canadian members did not vote on the consortium's statement.
Human life is a staggeringly strange thing. On the surface of a ball of rock falling around a nuclear fireball in the blackness of a vacuum the laws of nature conspired to create a naked ape that can look up at the stars and wonder where it came from. What is a human being? Objectively, nothing of consequence. Particles of dust in an infinite arena, present for an instant in eternity. Clumps of atoms in a universe with more galaxies than people. And yet a human being is necessary for the question itself to exist, and the presence of a question in the universe - any question - is the most wonderful thing. Questions require minds, and minds bring meaning. What is meaning? I don't know, except that the universe and every pointless speck inside it means something to me. I am astonished by the existence of a single atom, and find my civilisation to be an outrageous imprint on reality. I don't understand it. Nobody does, but it makes me smile. This book asks questions about our origins, our destiny, and our place i...
Full Text Available Vast numbers of proteins work cooperatively to exert their functions in various cells. In order to understand the functions and molecular mechanisms of these proteins in plants, analyses of transgenic plants that concomitantly express two protein-coding genes are often required. We developed a novel Gateway cloning technology-compatible binary vector system, the R4 dual-site (R4DS Gateway cloning system, which enables the easy and efficient cloning of two desired sets of promoters and open reading frames (ORFs into a binary vector using promoter and ORF entry clones. In this system, C-terminal fusions with 17 kinds of tags including visible reporters and epitope tags are available for each ORF, and selection by four kinds of resistance markers is possible. We verified that the R4DS Gateway cloning system functioned well in Arabidopsis thaliana by observing the expression and localization patterns of fluorescent proteins fused with organelle-targeting signals and driven by stomatal-lineage specific promoters. We also confirmed that the two cloning sites in the R4DS Gateway cloning system were equivalent and independently regulated. The results obtained indicate that the R4DS Gateway cloning system facilitates detailed comparisons of the expression patterns of two promoters as well as co-localization and interaction analyses of two proteins in specific cells in plants.
Thenkabail, Prasad S.; Biradar, Chandrashekhar; Noojipady, Praveen; Islam, Aminul; Vithanage, Jagath; Velpuri, Manohar; Dheeravath, Venkateswarlu; Kulawardhana, Wasantha; Li, Yuan Jie; Gunasinghe, Sarath; Alankara, Ranjith
The International Water Management Institute's Data and Knowledge Storehouse Pathway (IWMIDSP) was launched in June 2004 meeting the need identified in the IWMI 2002-2004 MTP Project 1: "Improved tools for assessment, accounting, planning and use of water resources for agriculture and food production." Since then to now, IWMIDSP (http://www.iwmidsp.org) has evolved as a pathfinder in providing over 3 terabyte of state-of-art value added remote sensing and GIS (RS/GIS) data and products of high scientific quality that are made available through online access for the global benchmark river basins, Nations, regions, and the entire World. The IWMIDSP has about 5 new registrations every day and currently (as on February 16, 2006) reaching a total permanent registrations of 1964 from over 50 Countries. Over last 1-year there has been, on an average, a constant stream of at least 2000 visitors from 70 Countries every month. To date, about 1.4 million hits have been recorded, 270,000 pages visited, and on an average 130 gigabytes of data downloaded every month. All data in IWMIDSP have accompanied by Meta data at international standard (FGDC). Our data users include students from leading Universities of the World, researchers from UN organizations, USGS, NASA, and National Institutions. Further the IWMIDSP link has been provided by over 50 web portals. The site has also been profiled by the World Health Organization, UN Human Settlement Program (UN HABITAT), and UN Economic Commission for Africa (UNECA). The IWMIDSP generated maps were widely used to understand and inform Tsunami damage and rehabilitation immediately after Tsunami by the coordinating National Office (CNO)-a Sri Lankan Presidential initiative (http://www.iwmidsp.org/iwmi/info/tsunami.asp). IWMIDSP hosted and disseminated real time Tsunami Response maps of Sri Lanka (an effort of IWMI and MapAction UK) to the world. These maps were not only popular with the non-Governmental Organizations (NGO's) working in
Michel Pentz est née en Afrique du Sud et venu au Cern en 1957 comme physicien et président de l'associaion du personnel. Il est également fondateur du mouvement Antiapartheid de Genève et a participé à la fondation de l'Open University en Grande-Bretagne. Il nous parle des contextes pédagogiques, culturels et nationaux dans lesquels la méthode peut s'appliquer.
Everyone has their own private universe. Ian's was immense and diverse. But there are two main parts that determined his world. One was of course PHYSICS. He was one of the rare breed for whom there was only one possible way of life. 10 years ago when his job prospects were bleak he was thinking of quitting physics and becoming a "taxi driver" which meant a financial analyst, a programmer, anything. For him all professions divided into two categories — physics and non-physics, a "taxi driver"…
Full Text Available Sectorial applications of seasonal forecasting require data for a reduced number of variables from different datasets, mainly (gridded observations, reanalysis, and predictions from state-of-the-art seasonal forecast systems (such as NCEP/CFSv2, ECMWF/System4 or UKMO/GloSea5. Whilst this information can be obtained directly from the data providers, the resulting formats, temporal aggregations, and vocabularies may not be homogeneous across datasets. Moreover, different data policies hold for the different databases, being only some of them publicly available. Therefore, obtaining and harmonizing multi-model seasonal forecast data for sector-specific applications is an error-prone, time consuming task.In order to facilitate this, the ECOMS User Data Gateway (ECOMS-UDG was developed in the framework of the ECOMS initiative as a one-stop-service for climate data. To this aim, the variables required by end users were identified, downloaded from the data providers and locally stored as virtual datasets in a THREDDS Data Server (TDS, implementing fine-grained user management and authorization via the THREDDS Access Portal (TAP. As a result, users can retrieve the subsets best suited to their particular research needs in a user-friendly manner using the standard TDS data services. Moreover, an open source, R-based interface for data access and postprocessing was developed in the form of a bundle of packages implementing harmonized data access (one single vocabulary, data collocation, bias adjustment and downscaling, and forecast visualization and validation. This provides a unique comprehensive framework for end-to-end applications of seasonal predictions, hence favoring the reproducibility of the ECOMS scientific outcomes, extensible to the whole scientific community. Keywords: Seasonal forecasting, Open science, THREDDS, Reproducibility, R software, Bias adjustment, Downscaling, Validation
Kaboodvand, Neda; Bäckman, Lars; Nyberg, Lars; Salami, Alireza
The default mode network (DMN) involves interacting cortical areas, including the posterior cingulate cortex (PCC) and the retrosplenial cortex (RSC), and subcortical areas, including the medial temporal lobe (MTL). The degree of functional connectivity (FC) within the DMN, particularly between MTL and medial-parietal subsystems, relates to episodic memory (EM) processes. However, past resting-state studies investigating the link between posterior DMN-MTL FC and EM performance yielded inconsistent results, possibly reflecting heterogeneity in the degree of connectivity between MTL and specific cortical DMN regions. Animal work suggests that RSC has structural connections to both cortical DMN regions and MTL, and may thus serve as an intermediate layer that facilitates information transfer between cortical and subcortical DMNs. We studied 180 healthy old adults (aged 64-68 years), who underwent comprehensive assessment of EM, along with resting-state fMRI. We found greater FC between MTL and RSC than between MTL and the other cortical DMN regions (e.g., PCC), with the only significant association with EM observed for MTL-RSC FC. Mediational analysis showed that MTL-cortical DMN connectivity increased with RSC as a mediator. Further analysis using a graph-theoretical approach on DMN nodes revealed the highest betweenness centrality for RSC, confirming that a high proportion of short paths among DMN regions pass through RSC. Importantly, the degree of RSC mediation was associated with EM performance, suggesting that individuals with greater mediation have an EM advantage. These findings suggest that RSC forms a critical gateway between MTL and cortical DMN to support EM in older adults. © 2018 Wiley Periodicals, Inc.
Gill, Mark E.; Hu, Yueh-Chiang; Lin, Yanfeng; Page, David C.
Mammalian oocytes and spermatozoa derive from fetal cells shared by the sexes. These primordial germ cells (PGCs) migrate to the developing somatic gonad, giving rise to oocytes or spermatozoa. These opposing sexual fates are determined not by the PGCs’ own sex chromosome constitution (XX or XY), but by the sexual identity of the fetal gonad that they enter. We asked whether PGCs undergo a developmental transition that enables them to respond to feminizing or masculinizing cues from fetal ovary or testis. We conducted in vivo genetic studies of DAZL, an RNA-binding protein expressed in both ovarian and testicular germ cells. We found that germ cells in C57BL/6 Dazl-deficient fetuses—whether XX or XY—migrate to the gonad but do not develop either male or female features. Instead, they remain in a sexually undifferentiated state similar to that of migrating PGCs. Thus, germ cells in C57BL/6 Dazl-deficient fetuses do not respond to sexual cues from ovary or testis, whereas the earlier processes of germ cell specification and migration are unaffected. We propose that PGCs of both XX and XY fetuses undergo licensing, an active developmental transition that enables the resultant gametogenesis-competent cells to respond to feminizing or masculinizing cues produced by the fetal ovary or testis and hence to embark on oogenesis or spermatogenesis. In C57BL/6 mice, Dazl is required for licensing. Licensing serves as a gateway from the embryonic processes shared between the sexes—germ cell specification and migration—to the sex-specific pathways of oogenesis and spermatogenesis. PMID:21504946
Full Text Available The thalamus is the primary gateway that relays sensory information to the cerebral cortex. While a single recipient cortical cell receives the convergence of many principal relay cells of the thalamus, each thalamic cell in turn integrates a dense and distributed synaptic feedback from the cortex. During sensory processing, the influence of this functional loop remains largely ignored. Using dynamic-clamp techniques in thalamic slices in vitro, we combined theoretical and experimental approaches to implement a realistic hybrid retino-thalamo-cortical pathway mixing biological cells and simulated circuits. The synaptic bombardment of cortical origin was mimicked through the injection of a stochastic mixture of excitatory and inhibitory conductances, resulting in a gradable correlation level of afferent activity shared by thalamic cells. The study of the impact of the simulated cortical input on the global retinocortical signal transfer efficiency revealed a novel control mechanism resulting from the collective resonance of all thalamic relay neurons. We show here that the transfer efficiency of sensory input transmission depends on three key features: i the number of thalamocortical cells involved in the many-to-one convergence from thalamus to cortex, ii the statistics of the corticothalamic synaptic bombardment and iii the level of correlation imposed between converging thalamic relay cells. In particular, our results demonstrate counterintuitively that the retinocortical signal transfer efficiency increases when the level of correlation across thalamic cells decreases. This suggests that the transfer efficiency of relay cells could be selectively amplified when they become simultaneously desynchronized by the cortical feedback. When applied to the intact brain, this network regulation mechanism could direct an attentional focus to specific thalamic subassemblies and select the appropriate input lines to the cortex according to the descending
École de physique - Département de physique nucléaire et corpusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Wednesday 13 May 2009 PARTICLE PHYSICS SEMINAR at 17:00 – Stückelberg Auditorium Observing the extreme universe with the Fermi Gamma-ray Space Telescope Prof. Olaf Reimer / Stanford University The Fermi Gamma-ray Space Telescope (FGST, formerly GLAST) is an international observatory-type satellite mission with a physics program spanning from gamma-ray astronomy to particle astrophysics and cosmology. FGST was launched on June 11, 2008 and is successfully conducting science observations of the high-energy gamma-ray sky since August 2008. A varienty of discoveries has been made already, including monitoring rapid blazar variability, the existence of GeV gamma-ray bursts, and numerous new gamma-ray sources of different types, including those belonging to previously unknown gamma-ray source classes like msPSRs, globula...
École de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Monday 9 March 2009 COLLOQUIUM at 17:00 – Stückelberg Auditorium Are We Descended From Heavy Neutrinos? Prof. Boris Kayser / Fermilab (Fermi National Accelerator Center, Geneva, Illinois, USA) Neutrinos are among the most abundant particles in the universe. The discovery that they have nonzero masses has raised a number of very interesting questions about them, and about their connections to other areas of physics and to cosmology. After briefly reviewing what has been learned about the neutrinos so far, we will identify the major open questions, explain why they are interesting, and discuss ideas and plans for answering them through future experiments. We will highlight a particularly intriguing question: Are neutrinos the key to understanding why the universe contains matter but almost no antimatter, making it s...
Aguirre G., J. A.
Full Text Available Protected areas and national parks are becoming one of the most important forms of land use in Central America. All the projections made by the World Tourism Organization seems to agree that by 2010 Central America, maybe receiving between eight and ten millions tourists, a figure that is almost twice what the region is receiving today. A study was conducted base on 369 direct field surveys conducted in three Central American communities: Bagazit gateway community to Palo Verde National Park, Costa Rica, Nindiri, gateway community to Volcan Masaya National Park, Nicaragua and Portobelo, gateway community to Por-tobelo National Park, Panama. The study found that relative to the socio-demographic variables, that there were no significance differences at the 95% probability level in all four variables, age, sex, education and monthly income of the family. Educational level seems to be the socio-demographic variables affecting more the state of relations. The perception variable being has taken into account in the decision that affects the communities and responsibility to help with community problems are present in two of the three models. The perception variables related to tourism, feel trained to take care of the tourist and existence of businesses that can caters to tourist seem to be key elements in the community perception about the state of relation. Tourism related economic activities and community participation in park decisions are today and will be in the future essential elements in the shaping of community/park relations in Central America as tourism becomes a major economic sector in the region economy.
Phillips, Carl V
It is often claimed that low-risk drugs still create harm because of "gateway effects", in which they cause the use of a high-risk alternative. Such claims are popular among opponents of tobacco harm reduction, claiming that low-risk tobacco products (e.g., e-cigarettes, smokeless tobacco) cause people to start smoking, sometimes backed by empirical studies that ostensibly support the claim. However, these studies consistently ignore the obvious alternative causal pathways, particularly that observed associations might represent causation in the opposite direction (smoking causes people to seek low-risk alternatives) or confounding (the same individual characteristics increase the chance of using any tobacco product). Due to these complications, any useful analysis must deal with simultaneity and confounding by common cause. In practice, existing analyses seem almost as if they were designed to provide teaching examples about drawing simplistic and unsupported causal conclusions from observed associations. The present analysis examines what evidence and research strategies would be needed to empirically detect such a gateway effect, if there were one, explaining key methodological concepts including causation and confounding, examining the logic of the claim, identifying potentially useful data, and debunking common fallacies on both sides of the argument, as well as presenting an extended example of proper empirical testing. The analysis demonstrates that none of the empirical studies to date that are purported to show a gateway effect from tobacco harm reduction products actually does so. The observations and approaches can be generalized to other cases where observed association of individual characteristics in cross-sectional data could result from any of several causal relationships.
Lee, Peter N
The "gateway hypothesis" usually refers to the possibility that the taking up of habit A, which is considered harmless (or less harmful), may lead to the subsequent taking up of another habit, B, which is considered harmful (or more harmful). Possible approaches to designing and analysing studies to test the hypothesis are discussed. Evidence relating to the use of snus (A) as a gateway for smoking (B) is then evaluated in detail. The importance of having appropriate data available on the sequence of use of A and B and on other potential confounding factors that may lead to the taking up of B is emphasised. Where randomised trials are impractical, the preferred designs include the prospective cohort study in which ever use of A and of B is recorded at regular intervals, and the cross-sectional survey in which time of starting to use A and B is recorded. Both approaches allow time-stratified analytical methods to be used, in which, in each time period, risk of initiating B among never users of B at the start of the interval is compared according to prior use of A. Adjustment in analysis for the potential confounding factors is essential. Of 11 studies of possible relevance conducted in Sweden, Finland or Norway, only one seriously addresses potential confounding by those other factors involved in the initiation of smoking. Furthermore, 5 of the 11 studies are of a design that does not allow proper testing of the gateway hypothesis for various reasons, and the analysis is unsatisfactory, sometimes seriously, in all the remaining six. While better analyses could be attempted for some of the six studies identified as having appropriate design, the issues of confounding remain, and more studies are clearly needed. To obtain a rapid answer, a properly designed cross-sectional survey is recommended.
Provensi, Gustavo; Fabbri, Roberta; Munari, Leonardo; Costa, Alessia; Baldi, Elisabetta; Bucherelli, Corrado; Blandina, Patrizio; Passani, Maria Beatrice
University Press on behalf of CINP.
The goal of this project was to prototype a Web based computational and collaboratory environment that would act as a commodity technologies based front-end or Gateway to larger HPC systems such as ANL LabSpace. The original name - WebSpace - proposed for such a system was taken during the course of this project by Silicon Graphics and used for their Web authoring environment. To avoid confusion, we changed the name of this project's system to WebFlow.
Ecole de physique - Département de physique nucléaire et corpusculaire 24, Quai Ernest-Ansermet 1211 GENEVE 4 Tél: (022) 379 62 73 Fax: (022) 379 69 92 Monday 28 April 2008 PHYSICS COLLOQUIUM at 17.00 – Stückelberg Auditorium Gravity : an Emergent Perspective by Prof. Thanu Padmanabhan, Pune University Dean, Ganeshkhind, Pune, India I will motivate and describe a novel perspective in which gravity arises as an emergent phenomenon, somewhat like elasticity. This perspective throws light on several issues which are somewhat of a mystery in the conventional approach. Moreover it provides new insights on the dark energy problem. In fact, I will show that it is necessary to have such an alternative perspective in order to solve the cosmological constant problem.Information: http://theory.physics.unige.ch/~fiteo/seminars/COL/collist.html
École de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Wednesday 18 November 2009 PARTICLE PHYSICS SEMINAR at 17:00 – Stückelberg Auditorium Highlights of the European Strategy Workshop for Future Neutrino Physics Dr Ilias Efthymiopoulos, CERN Seminar cancelled! Information Organizer : J.-S. Graulich Monday 7 December 2009 PHYSICS COLLOQUIUM at 17:00 – Stückelberg Auditorium Topological insulators and topological superconductors Professor Shoucheng Zhang Department of Physics, Stanford University, CA Recently, a new class of topological states has been theoretically predicted and experimentally realized. The topological insulators have an insulating gap in the bulk, but have topologically protected edge or surface states due to the time reversal symmetry. In two dimensions the edge s...
École de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Monday 7 December 2009 PHYSICS COLLOQUIUM at 17:00 – Stückelberg Auditorium Topological insulators and topological superconductors Professor Shoucheng Zhang Department of Physics, Stanford University, CA Recently, a new class of topological states has been theoretically predicted and experimentally realized. The topological insulators have an insulating gap in the bulk, but have topologically protected edge or surface states due to the time reversal symmetry. In two dimensions the edge states give rise to the quantum spin Hall (QSH) effect, in the absence of any external magnetic field. I shall review the theoretical prediction of the QSH state in HgTe/CdTe semiconductor quantum wells, and its recent experimental observation. The edge states of the QSH state supports fr...
École de physique - Département de physique nucléaire et corpusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Lundi 6 avril 2009 PARTICLE PHYSICS SEMINAR àt 17:00 – Auditoire Stückelberg Hospital superbugs, nanomechanics and statistical physics Prof. Dr G. Aeppli / University College London The alarming growth of the antibiotic-resistant superbug, methicillin-resistant Staphylococcus aureus (MRSA) is driving the development of new technologies to investigate antibiotics and their modes of action. We report silicon cantilever based studies of self-assembled monolayers of mucopeptides which model drug-sensitive and resistant bacterial walls. The underlying concepts needed to understand the measurements will simplify the design of cantilevers and coatings for biosensing and could even impact our understanding of drug action on bacteria themselves. (Une verrée en compagnie du conférencier sera offerte après le colloque.) Organizer : Prof. Markus Büttiker ...
École de physique - Département de physique nucléaire et corpusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Wednesday 25 March 2009 PARTICLE PHYSICS SEMINAR at 17:00 – Stückelberg Auditorium Hunting for the Higgs with D0 at the Tevatron Prof. Gustaaf Brooijmans / Columbia University The search for the Higgs boson is one of the most important endeavors in current experimental particle physics. At the eve of the LHC start, the Tevatron is delivering record luminosity allowing both CDF and D0 to explore a new region of possible Higgs masses. In this seminar, the techniques used to search for the Higgs boson at the Tevatron will be explained, limiting factors will be examined, and the sensitivity in the various channels will be reviewed. The newly excluded values of the standard model Higgs mass will be presented. Information : http://dpnc.unige.ch/seminaire/annonce.html Organizer : J.-S. Graulich
École de physique - Département de physique nucléaire et corpusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Wednesday 29 April 2009 PARTICLE PHYSICS SEMINAR at 17:00 - Stückelberg Auditorium Search for spin-1 excited bosons at the LHC Mihail V. Chizhov (Physics Department, Sofia University, Bulgaria) I will discuss the resonance production of new type spin-1 excited bosons, Z*, at hadron colliders. They can be observed as a Breit-Wigner resonance peak in the invariant dilepton mass distribution in the same way as the well-known hypothetical gauge bosons, Z�. This makes them very interesting objects for early searches with the LHC first data. Moreover, they have unique signatures in transverse momentum and angular distributions, which allow to distinguish them from other resonances. Information : http://dpnc.unige.ch/seminaire/annonce.html Organizer: J.-S. Graulich
Ecole de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENEVE 4 Tel: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 14 April 2010 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Dark Matter and the XENON Experiment By Dr. Marc Schumann, Physik Institut, Universität Zürich There is convincing astrophysical and cosmological evidence that most of the matter in the Universe is dark: It is invisible in every band of the electromagnetic spectrum. Weakly interacting massive particles (WIMPs) are promising Dark Matter candidates that arise naturally in many theories beyond the Standard Model. Several experiments aim to directly detect WIMPs by measuring nuclear recoils from WIMPs scattered on target nuclei. In this talk, I will give an overview on Dark Matter and direct Dark Matter detection. Then I will focus on the XENON100 experiment, a 2-phase liquid/gas time projection chamber (TPC) that ...
Universal Algebra, heralded as ". . . the standard reference in a field notorious for the lack of standardization . . .," has become the most authoritative, consistently relied on text in a field with applications in other branches of algebra and other fields such as combinatorics, geometry, and computer science. Each chapter is followed by an extensive list of exercises and problems. The "state of the art" account also includes new appendices (with contributions from B. Jónsson, R. Quackenbush, W. Taylor, and G. Wenzel) and a well-selected additional bibliography of over 1250 papers and books which makes this a fine work for students, instructors, and researchers in the field. "This book will certainly be, in the years to come, the basic reference to the subject." --- The American Mathematical Monthly (First Edition) "In this reviewer's opinion [the author] has more than succeeded in his aim. The problems at the end of each chapter are well-chosen; there are more than 650 of them. The book is especially sui...
Arkani-Hamed, Nima; Dimopoulos, Savas; Kaloper, Nemanja; Dvali, Gia
We propose that our world is a brane folded many times inside the sub-millimeter extra dimensions. The folding produces many connected parallel branes or folds with identical microphysics - a Manyfold. Nearby matter on other folds can be detected gravitationally as dark matter since the light it emits takes a long time to reach us traveling around the fold. Hence dark matter is microphysically identical to ordinary matter; it can dissipate and clump possibly forming dark replicas of ordinary stars which are good MACHO candidates. Its dissipation may lead to far more frequent occurrence of gravitational collapse and consequently to a significant enhancement in gravitational wave signals detectable by LIGO and LISA. Sterile neutrinos find a natural home on the other folds. Since the folded brane is not a BPS state, it gives a new geometric means for supersymmetry breaking in our world. It may also offer novel approach for the resolution of the cosmological horizon problem, although it still requires additional dynamics to solve the flatness problem. Although there are constraints from BBN, structure formation, the enormity of galactic halos and the absence of stars and globular clusters with a discernible dark matter component, we show that the model is consistent with current observational limits. It presents us with a new dark matter particle and a new framework for the evolution of structure in our universe.
Ecole de physique - Département de physique nucléaire et corpusculaire 24, Quai Ernest-Ansermet 1211 GENEVE 4 Tél: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 29 October 2008 PARTICLE PHYSICS SEMINAR at 17.00 – Stückelberg Auditorium Precision measurements of low-energy neutrino-nucleus interactions with the SciBooNE experiment at Fermilab by Dr Michel Sorel, IFIC (CSIC and University of Valencia) «Do all modern accelerator-based neutrino experiments need to make use of kiloton-scale detectors and decade-long exposure times? In order to study the full pattern of neutrino mixing via neutrino oscillation experiments, the answer is probably yes, together with powerful proton sources. Still, to push the sensitivity of future neutrino oscillation searches into unchartered territory, those are necessary, but not sufficient, ingredients. In addition, accurate knowledge of neutrino interactions and neutrino production is mandatory. This knowledge can be acquired via small-scale and short-term dedicated n...
École de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 Genève 4 Tél. 022 379 62 73 - Fax: (022) 379 69 92 Wednesday 14 October 2009 PARTICLE PHYSICS SEMINAR at 17:00 – Stückelberg Auditorium Long-lived particle searches at colliders Dr. Philippe Mermod / Oxford University The discovery of exotic long-lived particles would address a number of important questions in modern physics such as the origin and composition of dark matter and the unification of the fundamental forces. This talk will focus on searches for long-lived charged massive particles, where "charged" refers to the magnetic, electric or colour charge. Previous searches at the LEP and Tevatron Colliders allowed to put mass and cross section limits on various kinds of long-lived particles, such as Magnetic Monopoles and metastable leptons and up-type quarks. The new energy regime made available at the LHC will probe physics regions well beyond these limits. F...
Etchells J Peter
Full Text Available Abstract Background The progress and completion of various plant genome sequencing projects has paved the way for diverse functional genomic studies that involve cloning, modification and subsequent expression of target genes. This requires flexible and efficient procedures for generating binary vectors containing: gene fusions, variants from site-directed mutagenesis, addition of protein tags together with domain swaps and deletions. Furthermore, efficient cloning procedures, ideally high throughput, are essential for pyramiding of multiple gene constructs. Results Here, we present a simple, flexible and efficient PCR-fusion/Gateway cloning procedure for construction of binary vectors for a range of gene fusions or variants with single or multiple nucleotide substitutions, short sequence insertions, domain deletions and swaps. Results from selected applications of the procedure which include ORF fusion, introduction of Cys>Ser mutations, insertion of StrepII tag sequence and domain swaps for Arabidopsis secondary cell wall AtCesA genes are demonstrated. Conclusion The PCR-fusion/Gateway cloning procedure described provides an elegant, simple and efficient solution for a wide range of diverse and complicated cloning tasks. Through streamlined cloning of sets of gene fusions and modification variants into binary vectors for systematic functional studies of gene families, our method allows for efficient utilization of the growing sequence and expression data.
Nayegandhi, Amar; Vivekanandan, Saisudha; Brock, J.C.; Wright, C.W.; Bonisteel-Cormier, J.M.; Nagle, D.B.; Klipp, E.S.; Stevens, Sara
These remotely sensed, geographically referenced elevation measurements of lidar-derived bare-earth (BE) and first-surface (FS) topography datasets were produced collaboratively by the U.S. Geological Survey (USGS), St. Petersburg Coastal and Marine Science Center, St. Petersburg, FL, and the National Park Service (NPS), Northeast Coastal and Barrier Network, Kingston, RI. This project provides highly detailed and accurate datasets of a portion of the Sandy Hook Unit of Gateway National Recreation Area in New Jersey, acquired post-Nor'Ida (November 2009 nor'easter) on December 4, 2009. The datasets are made available for use as a management tool to research scientists and natural-resource managers. An innovative airborne lidar instrument originally developed at the NASA Wallops Flight Facility, and known as the Experimental Advanced Airborne Research Lidar (EAARL), was used during data acquisition. The EAARL system is a raster-scanning, waveform-resolving, green-wavelength (532-nanometer) lidar designed to map near-shore bathymetry, topography, and vegetation structure simultaneously. The EAARL sensor suite includes the raster-scanning, water-penetrating full-waveform adaptive lidar, a down-looking red-green-blue (RGB) digital camera, a high-resolution multispectral color infrared (CIR) camera, two precision dual-frequency kinematic carrier-phase GPS receivers, and an integrated miniature digital inertial measurement unit, which provide for sub-meter georeferencing of each laser sample. The nominal EAARL platform is a twin-engine aircraft, but the instrument was deployed on a Pilatus PC-6. A single pilot, a lidar operator, and a data analyst constitute the crew for most survey operations. This sensor has the potential to make significant contributions in measuring sub-aerial and submarine coastal topography within cross-environmental surveys. Elevation measurements were collected over the survey area using the EAARL system, and the resulting data were then
Full Text Available The municipality of Fiumicino, indipendent of Rome since 1992, plays two important roles in regional planning: it can be considered both an autonomous town and a satellite city of Rome. Because of its recent history, actually Fiumicino’s territory still presents the outskirts characteristics (many residential areas, lack of important public and private services, low quality of buildings and public spaces, inadequate infrastructures and not the shape of an independent town, although some chief and characteristics elements like the fish market, which is one of the most important of the Mediterranean sea, and the archaeological area of the ancient port, build at the time of the Emperor Traiano (II p.C.. In fact, at that time, Fiumicino had a specific identity: it represented the gate of Rome from the sea thanks to this port, which was renovated several times because of problems concerning the seabed. Then, after many transformations and attempts of requalification, the port was definitively transformed into a fishing dock. Since 1960, Fiumicino has played this ancient role again, thanks to the construction of the Leonardo Da Vinci Airport; now it is considered the gateway of Rome from the air, while the same role from the sea belongs to Civitavecchia’s port. However it’s important to say that the airport and the town are adjacent but not integrated. In fact, today, because of Capital’s process of growth, which absorbs all near minor towns, and because of the airport, Fiumicino is considered only an appendix of Rome, without a specific identity, but in the last years, some infrastructural aspects have been reconsidered, like its geographical position on the cost and the short distance between the town and some important poles like Rome, Civitavecchia’s port and the industrial areas of Gaeta and Pomezia. So the port authority of Civitavecchia has decided to extend its administration to the areas of Gaeta, which just has a trade port, and
This history of language policy traces the fortunes of Dutch in the East Indies from the arrival of the first Dutchmen in the Indonesian archipelago at the end of the sixteenth century to the transfer of sovereignty in 1949.Groeneboer explores the authorities' intentions with regard to Dutch and the
Tomillero, A; Moral, M A
(-)-Gossypol; Abacavir sulfate/lamivudine, ACAM-1000, ACE-011, Agomelatine, AGS-004, Alemtuzumab, Alvocidib hydrochloride, AMG-317, Amlodipine, Aripiprazole, Atazanavir sulfate, Azacitidine; Becatecarin, Belinostat, Bevacizumab, BMS-387032, BMS-690514, Bortezomib; Casopitant mesylate, Cetuximab, Choline fenofibrate, CK-1827452, Clofarabine, Conivaptan hydrochloride; Dabigatran etexilate, DADMe-Immucillin-H, Darbepoetin alfa, Darunavir, Dasatinib, DC-WT1, Decitabine, Deferasirox, Degarelix acetate, Denenicokin, Denosumab, Dienogest, Duloxetine hydrochloride; Ecogramostim, Eculizumab, Edoxaban tosilate, Elacytarabine, Elesclomol, Eltrombopag olamine, Enfuvirtide, Enzastaurin hydrochloride, Eribulin mesilate, Erlotinib hydrochloride, Escitalopram oxalate, Eszopiclone, Etravirine; Flibanserin, Fludarabine, Fondaparinux sodium, Fosamprenavir calcium; Gefitinib, Genistein; I-131-L19-SIP, Idrabiotaparinux sodium, Imatinib mesylate, IMGN-901, Ipilimumab; Laromustine, Lenalidomide, Liposomal cisplatin, Liraglutide, Lisdexamfetamine mesilate, Lopinavir, Lopinavir/ritonavir; Maraviroc, MDV-3100, Mecasermin rinfabate, MP-470, Mycophenolic acid sodium salt; Naproxcinod, NB-002, Nesiritide, Nilotinib hydrochloride monohydrate, NK-012; Palonosetron hydrochloride, Panobinostat, Pegfilgrastim, Peginterferon alfa-2a, Pitavastatin calcium, PL-3994, Plerixafor hydrochloride, Plitidepsin, PM-10450; Raltegravir potassium, Recombinant human soluble thrombomodulin, ReoT3D, RHAMM R3 peptide, Rivaroxaban, Romiplostim, Rosuvastatin calcium, Rozrolimupab; Sabarubicin hydrochloride, Salinosporamide A, Sirolimus-eluting stent, Smallpox (Vaccinia) Vaccine, Live, Sorafenib; Tenofovir disoproxil fumarate, Tenofovir disoproxil fumarate/emtricitabine, Teriparatide, Tipifarnib, Tipranavir, Trabectedin, Trifluridine/TPI; Vardenafil hydrochloride hydrate, Vinflunine, Volociximab, Vorinostat; Ximelagatran; Yttrium 90 (90Y) ibritumomab tiuxetan; Ziprasidone hydrochloride, Zoledronic acid monohydrate. Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
Tomillero, A; Moral, M A
[¹¹C]RAC; (18)F-Fluoromisonidazole; 89-12; 9-[¹⁸F]Fluoropropyl-(+)-dihydrotetrabenazine; Adalimumab, Adecatumumab, ADMVA, ADXS-11-001, Aflibercept, Agatolimod sodium, AGS-004, Alglucosidase alfa, Aliskiren fumarate, Alvocidib hydrochloride, AMG-108, AMG-853, Apixaban, Aripiprazole, Armodafinil, Atazanavir sulfate, Atomoxetine hydrochloride; Bevacizumab, BioMatrix Flex drug eluting stent, Biphasic insulin aspart, Bortezomib, Bosentan; Caspofungin acetate, Cediranib, Cetuximab, ChimeriVax-Dengue, Choriogonadotropin alfa, Cinacalcet hydrochloride, Cizolirtine citrate, Clofarabine, Cocaine conjugate vaccine, CX-717; Darbepoetin alfa, Dasatinib, Decitabine, Denosumab, Desvenlafaxine succinate, Dexamethasone sodium phosphate, Dienogest, Diphencyprone, Doripenem, DTaP-HepB-IPV, Dutasteride; E-7010, Ecallantide, Ecstasy, Eicosapentaenoic acid/docosahexaenoic acid, Emtricitabine, Enfuvirtide, Erlotinib hydrochloride, Eszopiclone, Etonogestrel/ethinyl estradiol, Etoricoxib, Everolimus, Everolimus-eluting coronary stent EVT-201, Ezetimibe, Ezetimibe/simvastatin; Ferumoxytol, Fesoterodine fumavate, Figitumumab, Filgrastim, Fingolimod hydrochloride, Fluticasone furoate, Fluval P, Fluzone, Fondaparinux sodium, Fulvestrant, Fungichromin; Gamma-hydroxybutyrate sodium, Gefitinib, GHB-01L1, GLY-230, GSK-1349572; Hib-MenCY-TT, Hib-TT, HPV-6/11/16/18, Hydrocodone bitartrate; IC-51, Icatibant acetate, Imatinib mesylate, Immunoglobulin intravenous (human), Indetanib, Influenza A (H1N1) 2009 Monovalent Vaccine, Inhalable human insulin, Insulin glargine, Insulin glulisine, Interferon-beta, Ispinesib mesylate, Ixabepilone; Laromustine, Latanoprost/timolol maleate, L-Citrulline, Lenalidomide, Lexatumumab, Linezolid, Lopinavir/ritonavir, Lutropin alfa; Mapatumumab, MDX-066, MDX-1388, Mepolizumab, Methoxy polyethylene glycol-epoetin-beta, Metreleptin, Micafungin sodium, Mometasone furoate/oxymetazoline hydrochloride, Mx-dnG1, Mycophenolic acid sodium salt; Nabiximols, Natalizumab, Nemonoxacin, Norelgestromin/ethinyl estradiol; Oblimersen sodium, Ocriplasmin, Olmesartan medoxomil, Omacetaxine mepesuccinate; Paclitaxel-eluting stent, Pagoclone, Paliperidone, Panitumumab, Pazopanib hydrochloride, PCV7, Pegaptanib octasodium, Peginterferon alfa-2a, Peginterferon alfa-2b/ ribavirin, Pegvisomant, Pemetrexed disodium, Perifosine, Pimecrolimus, Pitavastatin calcium, Plerixafor hydrochloride, Plitidepsin, Posaconazole, Pregabalin, Progesterone capriate; Raltegravir potassium, Ramucirumab, Ranelic acid distrontium salt, Rasburicase, Recombinant Bet V1, Recombinant human insulin, rhFSH, Rolofylline, Romidepsin, Romiplostim, Rosuvastatin calcium; Sapacitabine, Sevelamer carbonate, Sinecatechins, Sirolimus-eluting stent, Sitagliptin phosphate monohydrate, SN-29244, Sorafenib, Sugammadex sodium, Sunitinib malate; Tadalafil, Tafenoquine, Talnetant, Tanezumab, Tapentadol hydrochloride, Tasocitinib citrate, Technosphere/Insulin, Telcagepant, Tenofovir disoproxil fumarate, Teriparatide, Ticagrelor, Tigecycline, Tiotropium bromide, Tipifarnib, Tocilizumab, TS-041; Ulipristal acetate, Urtoxazumab, Ustekinumab; Vandetanib, Varenicline tartrate, Vicriviroc, Voriconazole, Vorinostat, VRC-HIVADV014-00-VP, VRC-HIVDNA016-00-VP; Zoledronic acid monohydrate. Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved.
Saavedra, David R. M.
Landing in a totally new culture and learning to speak a new language is overwhelming--as the author found out when he was a Peace Corps volunteer in Africa. Now he tries to remember these lessons while teaching immigrant students in the Cambridge, Massachusetts. Empathizing with language learners in their struggle to learn English while coping…
Parhonyi, R.; Párhonyi, Róbert
In the next years, the market for low value online content, like music and videos, is expected to grow substantially. To allow "pay-per-use" of such content, micropayment systems are expected to play an important role. Since there are already many competing micropayment systems on the market,
Suzuki, Yasuhiro; Kagawa, Naoko; Fujino, Toru; Sumiya, Tsuyoshi; Andoh, Taichi; Ishikawa, Kumiko; Kimura, Rie; Kemmochi, Kiyokazu; Ohta, Tsutomu; Tanaka, Shigeo
There is an increasing demand for easy, high-throughput (HTP) methods for protein engineering to support advances in the development of structural biology, bioinformatics and drug design. Here, we describe an N- and C-terminal cloning method utilizing Gateway cloning technology that we have adopted for chimeric and mutant genes production as well as domain shuffling. This method involves only three steps: PCR, in vitro recombination and transformation. All three processes consist of simple handling, mixing and incubation steps. We have characterized this novel HTP method on 96 targets with >90% success. Here, we also discuss an N- and C-terminal cloning method for domain shuffling and a combination of mutation and chimeragenesis with two types of plasmid vectors.
Adiba Kamalia Putri
Full Text Available Penelitian ini bertujuan untuk mengembangkan sistem absensi mahasiswa menggunakan RFID reader dan RFID tag dengan menambahkan perhitungan sanksi kompensasi ketika mahasiswa terlambat atau tidak hadir dalam perkuliahan dan adanya absensi dosen. Setiap RFID reader memiliki IP Address yang berbeda namun masih dalam satu class yang sama. Pengembangan juga dilakukan dengan menambahkan informasi kepada orang tua ketika jumlah ketidakhadiran mahasiswa sudah melampaui batas yang ditentukan sehingga dapat dikenai surat peringatan 1, 2, dan 3. Mahasiswa juga akan mendapat pemberitahuan jika jumlah ketidakhadirannya sudah melampaui batas yang ditentukan. Semua pemberitahuan tersebut dikirimkan melalui SMS Gateway secara realtime. Untuk pemberitahuan jika jumlah ketidakhadirannya sudah melampaui batas juga dikirimkan melalui email kepada mahasiswa dan kaprodi. Metode pengembangan dengan menambahkan aturan perhitungan kompensasi pada program RTEvent yang digunakan. Hasil dari pembuatan sistem ini adalah tersusunnya sistem pencatatan kehadiran mahasiswa dan dosen yang sudah dilengkapi dengan perhitungan kompensasi dan adanya pemberitahuan informasi kegitan belajar mengajar kepada orang tua dan kaprodi.
Christopher J. Savage
Full Text Available Many developing countries wish to become the ‘gateway’ to a region or part of a continent.One strategy involves encouraging logistics cluster development. These hubs support global supply chains and may enable the economic growth of the host country through the resulting trade, as well as providing direct and indirect employment opportunities during the build and subsequent operation of the hub. Namibia intends to develop the Port of Walvis Bay to be come the preferred gateway to southern Africa and the Southern African Development Community region. This article builds on research on Caribbean cluster potential and Namibian logistics to identify the potential benefits and impact on development, as well as the drawbacks and risks of such a strategy.
Full Text Available This paper considers the degree of competition among small and medium-sized container ports located in a multi-port gateway region. The level of port competition is evaluated by means of an analysis of the revealed preferences in the port-calling pattern of container feeder vessels deployed on their various links and routes. Unit of analysis is feeder vessel sailing legs and ports stays at/between adjacent container ports. At these ports’ terminals, ships are moored and loading and unloading of containers are performed. The vessel movement data is provided by the Automatic Identification System (AIS. A study of the principal container ports in the Oslo Fjord area is performed, measuring the actual container feeder traffic during the year of 2015. It is demonstrated to which extent ports in the Oslo Fjord region are acting as substitutes, and to which extent they are functioning more as a complement to each other.
Wilkerson, Andrea M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Abell, Thomas C. [Univ. of Maryland, College Park, MD (United States); Perrin, Tess E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
The University of Maryland (UMD) began retrofitting halogen wall washers in the Clarice Smith Performing Arts Center (CSPAC) in April 2014. The U.S. Department of Energy (DOE) Solid-State Lighting (SSL) GATEWAY program documented this process through the final installation in March 2015, summarized in this report. The wall washers illuminate hallways lining the atrium, providing task illuminance for transitioning between spaces and visual interest to the atrium boundaries. The main goals of the retrofit were to maintain the visual appearance of the space while reducing maintenance costs – energy savings was considered an additional benefit by UMD Facilities Management. UMD Facilities Management is pleased with the results of this retrofit, and continues to initiate LED retrofit projects across the UMD campus.
As universities make cross-sectoral alliances, various models for integrating postsecondary education into universities arise: contract, brokerage, collaborative, validation, joint program, dual-sector institution, tertiary university, metaphoric, and federal. The integrated, comprehensive university is the learning university of the 21st century.…
Dougherty, Peter J.
The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…
Preface; Introducing the masks; Part I. Worlds in the Making: 1. The magic Universe; 2. The mythic Universe; 3. The geometric Universe; 4. The medieval Universe; 5. The infinite Universe; 6. The mechanistic Universe; Part II. The Heart Divine: 7. Dance of the atoms and waves; 8. Fabric of space and time; 9. Nearer to the heart's desire; 10. The cosmic tide; 11. Do dreams ever come true?; Part III. The Cloud of Unknowing: 12. The witch universe; 13. The spear of Archytas; 14. All that is made; 15. The cloud of unknowing; 16. Learned ignorance.
Degenhardt, Louisa; Dierker, Lisa; Chiu, Wai Tat; Medina-Mora, Maria Elena; Neumark, Yehuda; Sampson, Nancy; Alonso, Jordi; Angermeyer, Matthias; Anthony, James C; Bruffaerts, Ronny; de Girolamo, Giovanni; de Graaf, Ron; Gureje, Oye; Karam, Aimee N; Kostyuchenko, Stanislav; Lee, Sing; Lépine, Jean-Pierre; Levinson, Daphna; Nakamura, Yosikazu; Posada-Villa, Jose; Stein, Dan; Wells, J Elisabeth; Kessler, Ronald C
It is unclear whether the normative sequence of drug use initiation, beginning with tobacco and alcohol, progressing to cannabis and then other illicit drugs, is due to causal effects of specific earlier drug use promoting progression, or to influences of other variables such as drug availability and attitudes. One way to investigate this is to see whether risk of later drug use in the sequence, conditional on use of drugs earlier in the sequence, changes according to time-space variation in use prevalence. We compared patterns and order of initiation of alcohol, tobacco, cannabis, and other illicit drug use across 17 countries with a wide range of drug use prevalence. Analyses used data from World Health Organization (WHO) World Mental Health (WMH) Surveys, a series of parallel community epidemiological surveys using the same instruments and field procedures carried out in 17 countries throughout the world. Initiation of "gateway" substances (i.e. alcohol, tobacco and cannabis) was differentially associated with subsequent onset of other illicit drug use based on background prevalence of gateway substance use. Cross-country differences in substance use prevalence also corresponded to differences in the likelihood of individuals reporting a non-normative sequence of substance initiation. These results suggest the "gateway" pattern at least partially reflects unmeasured common causes rather than causal effects of specific drugs on subsequent use of others. This implies that successful efforts to prevent use of specific "gateway" drugs may not in themselves lead to major reductions in the use of later drugs. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Bengtsen, Søren Smedegaard
- they are alien. The conditions of universities today is not one of crisis and upheaval, as with the postmodern universities, it is one of night travel and exile. The alien university leaves behind the epistemological skirmishes of the postmodern university with all its rhetoric and knowledge activism. Thinking...... in the alien university is a move into a whirlpool of nothingness, a “nocturnal space”, where “[d]arkness fills it like a content; it is full, but full of the nothingness of everything.” (Levinas, 2001, p.53). In the alien university thinking is not situated, and instead of rhizomes, and assemblages of thought......, there is merely an imposing and nightly “swarming of points.” (ibid.). There is no place for the alien university, and exactly this exile of thought makes possible the move beyond postmodernism and the mentality of political crisis. The alien university is not in the future as such, but it is not entirely...
Full Text Available This study proposes the elaboration of a meta-ranking, including the 14 Spanish universities which appear in at least four of the five global rankings considered in this study, that are some of the world’s most influential. It is necessary to differentiate between research rakings that use bibliometric data and rankings that take into account other aspects and other forms of data collection, basically based on surveys. Spanish universities attain better positions in the first group. The investigation highlighted that the higher weaknesses we can find are in the internationalization, the reputation or in the student-teacher ratio. The one exception is for universities that stand out in the two dimensions. Regarding the outcome, there is an evident need for a greater internationalisation, to improve the reputation of the higher education institutions and to enhance the international visibility of the Spanish universities.
This is an excerpt from Stephen Hawking's book The Universe in a Nutshell. Roger Penrose and Stephen Hawking, Lucasian Professor of Mathematics at the University of Cambridge, were able to show that Einstein's General Theory of Relativity implied that the universe and time itself must have had a beginning in a tremendous explosion. The discovery of the expansion of the universe is one of the great intellectual revolutions of the twentieth century.
Barrow, J.D.; California Univ., Berkeley; Turner, M.S.; Chicago Univ., IL
The problems of explaining the observed isotropy, homogeneity, flatness and specific entropy of the Universe are discussed in the context of an inflationary Universe which has recently been suggested. It is shown that the isotropy cannot be ignored as a Universe with a large amount of anisotropy will not undergo the inflationary phase. A Universe with only moderate anistropy will undergo inflation and will be rapidly isotropized. (U.K.)
Full Text Available In this article we describe the background, design, and preliminary results of a medications module within Patient Gateway (PG, a patient portal linked to an electronic health record (EHR. The medications module is designed to improve the accuracy of medication lists within the EHR, reduce adverse drug events and improve patient_provider communication regarding medications and allergies in several primary care practices within a large integrated healthcare delivery network. This module allows patients to view and modify the list of medications and allergies from the EHR, report nonadherence, side effects and other medication-related problems and easily communicate this information to providers, who can verify the information and update the EHR as needed. Usage and satisfaction data indicate that patients found the module easy to use, felt that it led to their providers having more accurate information about them and enabled them to feel more prepared for their forthcoming visits. Further analyses will determine the effects of this module on important medication-related outcomes and identify further enhancements needed to improve on this approach.
Caro-Rojas, Rosa Angela; Eslava-Schmalbach, Javier H
To compare the information obtained from the Medline database using Internet commercial search engines with that obtained from a compact disc (Medline-CD). An agreement study was carried out based on 101 clinical scenarios provided by specialists in internal medicine, pharmacy, gynaecology-obstetrics, surgery and paediatrics. 175 search strategies were employed using the connector AND plus text within quotation marks. The search was limited to 1991-1999. Internet search-engines were selected by common criteria. Identical search strategies were independently applied to and masked from Internet search engines, as well as the Medline-CD. 3,488 articles were obtained using 129 search strategies. Agreement with the Medline-CD was 54% for PubMed, 57% for Gateway, 54% for Medscape and 65% for BioMedNet. The highest agreement rate for a given speciality (paediatrics) was 78.1% for BioMedNet, having greater -/- than +/+ agreement. Even though free access to Medline has encouraged the boom and growth of evidence-based medicine, these results must be considered within the context of which search engine was selected for doing the searches. The Internet search engines studied showed a poor agreement with the Medline-CD, the rate of agreement differing according to speciality, thus significantly affecting searches and their reproducibility. Software designed for conducting Medline database searches, including the Medline-CD, must be standardised and validated.
Leah J Campbell
Full Text Available The ability to control transgene expression within specific tissues is an important tool for studying the molecular and cellular mechanisms of development, physiology, and disease. We developed a Tet-On system for spatial and temporal control of transgene expression in zebrafish rod photoreceptors. We generated two transgenic lines using the Xenopus rhodopsin promoter to drive the reverse tetracycline-controlled transcriptional transactivator (rtTA, one with self-reporting GFP activity and one with an epitope tagged rtTA. The self-reporting line includes a tetracycline response element (TRE-driven GFP and, in the presence of doxycycline, expresses GFP in larval and adult rods. A time-course of doxycycline treatment demonstrates that maximal induction of GFP expression, as determined by the number of GFP-positive rods, is reached within approximately 24 hours of drug treatment. The epitope-tagged transgenic line eliminates the need for the self-reporting GFP activity by expressing a FLAG-tagged rtTA protein. Both lines demonstrate strong induction of TRE-driven transgenes from plasmids microinjected into one-cell embryos. These results show that spatial and temporal control of transgene expression can be achieved in rod photoreceptors. Additionally, system components are constructed in Gateway compatible vectors for the rapid cloning of doxycycline-inducible transgenes and use in other areas of zebrafish research.
Exposito-Rodriguez, Marino; Laissue, Philippe P; López-Calcagno, Patricia E; Mullineaux, Philip M; Raines, Christine A; Simkin, Andrew J
Gateway technology has been used to facilitate the generation of a large number of constructs for the modification of plants for research purposes. However, many of the currently available vectors only allow the integration of a single cDNA of interest into an expression clone. The ability to over-express multiple genes in combination is essential for the study of plant development where several transcripts have a role to play in one or more metabolic processes. The tools to carry out such studies are limited, and in many cases rely on the incorporation of cDNA into expression systems via conventional cloning, which can be both time consuming and laborious. To our knowledge, this study reports on the first development of a vector allowing the simultaneous integration of two independent cDNAs via a single LR-clonase reaction. This vector " pGEMINI " represents a powerful molecular tool offering the ability to study the role of multi-cDNA constructs on plant development, and opens up the process of gene stacking and the study of gene combinations through transient or stable transformation procedures.
Kinkel, H.; Crudeli, D.; Groeneveld, J.; Nürnberg, D.; Steph, S.; Tiedemann, R.
We investigated evolutionary and geochemical trends in calcareous plankton organisms (coccolithophores and planktic foraminiferas) to address the changes in the paleoceanography and evolution associated with the closure of the Isthmus of Panama. The closing of this major ocean Gateway lead to substantial reorganizations of surface and deep ocean currents, and thus global climate change. Moreover it provides a unique opportunity to study the evolutionary development of planktic organisms, that are associated with these changes as well as their geographic separation in the Carribean and eastern Equatorial Pacific. The geochemical analysis of stable oxygen and carbon isotopes as well as Mg/Ca of planktic foraminiferas, provide a detailed view on the changing surface water properties of the investigated area. First results are already achieved on the evolution of the genus Gephyrocapsa and its origination from the genus Reticulofenestra. Morphometric studies have been carried out on both genera as well as on Pseudoemiliania ovata which evolves into Pseudoemiliania lacunosa during this interval. The ecological investigation of the total coccolithophore assemblages provide valuable insights to high frequency fluctuation in the trophic structure of coccolithophores which can be correlated to the paleoceanographic reconstructions based on the stable carbon and oxygen isotope and Mg/Ca records of planktic foraminiferas. The multidisciplinary approach enables us to decipher to what extend evolution is driven by intrinsic or extrinsic factors, and the high-resolution framework of this study provides valuable insights in the tempo of evolution and climate change.