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Sample records for bis salicylaldehyde orthophenylenediamine

  1. A Simple and Selective Spectrophotometric Method for the Determination of Trace Gold in Real, Environmental, Biological, Geological and Soil Samples Using Bis (Salicylaldehyde Orthophenylenediamine

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    Rubina Soomro

    2008-01-01

    Full Text Available A simple high sensitive, selective, and rapid spectrophotometric method for the determination of trace gold based on the rapid reaction of gold(III with bis(salicylaldehydeorthophenylenediamine (BSOPD in aqueous and micellar media has been developed. BSOPD reacts with gold(III in slightly acidic solution to form a 1:1 brownish-yellow complex, which has an maximum absorption peak at 490 nm in both aqueous and micellar media. The most remarkable point of this method is that the molar absorptivities of the gold-BSOPD complex form in the presence of the nonionic TritonX-100 surfactant are almost a 10 times higher than the value observed in the aqueous solution, resulting in an increase in the sensitivity and selectivity of the method. The apparent molar absorptivities were found to be 2.3 × 104 L mol−1 cm−1 and 2.5 × 105 L mol−1 cm−1 in aqueous and micellar media, respectively. The reaction is instantaneous and the maximum absorbance was obtained after 10 min at 490 nm and remains constant for over 24 h at room temperature. The linear calibration graphs were obtained for 0.1 –30 mg L−1 and 0.01 –30 mg L−1 of gold(III in aqueous and surfactant media, respectively. The interference from over 50 cations, anions and complexing agents has been studied at 1 mg L−1 of Au(III; most metal ions can be tolerated in considerable amounts in aqueous micellar solutions. The Sandell’s sensitivity, the limit of detection and relative standard deviation (n = 9 were found to be 5 ng cm−2, 1 ng mL−1 and 2%, respectively in aqueous micellar solutions. Its sensitivity and selectivity are remarkably higher than that of other reagents in the literature. The proposed method was successfully used in the determination of gold in several standard reference materials (alloys and steels, environmental water samples (potable and polluted, and biological samples (blood and urine, geological, soil and complex synthetic mixtures. The results obtained agree

  2. Spectroscopic studies of some lanthanide(III nitrate complexes synthesized from a new ligand 2,6-bis-(salicylaldehyde hydrazone-4-chlorophenol

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    A.S. Sall

    2003-06-01

    Full Text Available The ligand 2,6-bis-(salicylaldehydehydrazone-4-chlorophenol (H5L and its binuclear lanthanide(III nitrate complexes {[Ln2(H4L3(NO3](NO32.mH2O} where Ln = La, Ce, Pr, Nd, Sm, Gd, Dy, Er, Yb and Y, have been synthesized. The complexes were characterized by chemical analysis, conductance, magnetic moment measurements and infrared spectra. Infrared study indicates that the ligand behaves both as neutral and ionic O donors and as neutral N donors.

  3. An experimental and theoretical magneto-structural study of polynuclear Ni(II) complexes assembled from a versatile bis(salicylaldehyde)diamine polytopic ligand.

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    Oyarzabal, Itziar; Ruiz, José; Mota, Antonio J; Rodríguez-Diéguez, Antonio; Seco, José M; Colacio, Enrique

    2015-04-21

    Six novel Ni(II) complexes, ranging from mononuclear to tetranuclear, have been prepared from the polytopic symmetrical Mannich base ligand N,N'-dimethyl-N,N'-bis(2-hidroxy-3-formyl-5-bromo-benzyl)ethylenediamine (H2L) and different anionic coligands: [Ni(H2L)(NO3)(H2O)]NO3·H2O (), [Ni2(μ-L)(acac)2(H2O)]·CH3CN (), [Ni2(μ-L)(μ-OAc)(NCS)] (), [Ni3(μ-L)2(μ-OH2)2(H2O)(CH3CN)](NO3)2·4CH3CN (), [Ni4(μ-L)2(μ-OAc)2(μ-OCH3)2]·6H2O·2CH3OH () and [Ni4(μ-L)2(μ-OAc)2(μ-N3)2]·2H2O·CH3OH (). These complexes have been characterized by single crystal X-ray diffraction, magnetic measurements and DFT theoretical calculations. The structural analysis of these complexes reveals that the anionic coligand and reaction conditions play a fundamental role in determining their final structures and magnetic properties. Compound contains a monomeric cationic unit with the nickel ion coordinated in the external O4 site of the compartmental ligand H2L, which acts in a neutral zwitterionic form. Complexes and are dinuclear Ni2 neutral entities, in which the Ni(II) ions are connected through two μ-phenoxido bridging groups. The Ni(O)2Ni bridging fragment in is almost planar, whereas in is bent due to the additional presence of a syn-syn acetate bridge connecting the Ni(II) atoms. Complex has a bent trinuclear structure with double μ-phenoxido/μ-water bridges between the central and terminal nickel atoms. Complexes and are Ni4 complexes with defective dicubane structures, in which triple μ-phenoxido/μ1,1,1-X/syn-syn acetate and double μ-phenoxido/μ1,1,1-X mixed bridges connect central and terminal Ni(II) atoms, whereas double μ1,1,1-X bridging ligands link the central Ni(II) ions (X = methoxido and azido groups for and , respectively). Magnetic susceptibility measurements reveal that complex shows a moderate antiferromagnetic interaction between the Ni(II) ions through the double di-μ-phenoxido bridge, leading to a S = 0 ground state. Compared to , complex shows a much

  4. (Z)-Selective Takai olefination of salicylaldehydes.

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    Geddis, Stephen M; Hagerman, Caroline E; Galloway, Warren R J D; Sore, Hannah F; Goodman, Jonathan M; Spring, David R

    2017-01-01

    The Takai olefination (or Takai reaction) is a method for the conversion of aldehydes to vinyl iodides, and has seen widespread implementation in organic synthesis. The reaction is usually noted for its high ( E )-selectivity; however, herein we report the highly ( Z )-selective Takai olefination of salicylaldehyde derivatives. Systematic screening of related substrates led to the identification of key factors responsible for this surprising inversion of selectivity, and enabled the development of a modified mechanistic model to rationalise these observations.

  5. (Z-Selective Takai olefination of salicylaldehydes

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    Stephen M. Geddis

    2017-02-01

    Full Text Available The Takai olefination (or Takai reaction is a method for the conversion of aldehydes to vinyl iodides, and has seen widespread implementation in organic synthesis. The reaction is usually noted for its high (E-selectivity; however, herein we report the highly (Z-selective Takai olefination of salicylaldehyde derivatives. Systematic screening of related substrates led to the identification of key factors responsible for this surprising inversion of selectivity, and enabled the development of a modified mechanistic model to rationalise these observations.

  6. Halogenated salicylaldehyde azines: The heavy atom effect on aggregation-induced emission enhancement properties

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    Chen, Xiao-tong, E-mail: chenxiaotong@tsinghua.edu.cn [Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China); Tong, Ai-jun [Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (China)

    2014-01-15

    This study investigates the heavy-atom effect (HAE) on aggregation-induced emission enhancement (AIEE) properties of salicylaldehyde azines. For this purpose, a series of halogenated salicylaldehyde azine derivatives, namely, chloro-salicylaldehyde azine (1), bromo-salicylaldehyde azine (2) and iodo-salicylaldehyde azine (3) are synthesized. 1 and 2 display typical AIEE characteristics of salicylaldehyde azine compounds; whereas for the iodo-substituent in 3, is found to be effective “external” heavy atom quenchers to salicylaldehyde azine fluorescence in aggregated state. Based on its weak fluorescence in aggregated state and relative strong fluorescence in dispersed state, 3 can also be applied as a turn-on fluorescence probe for egg albumin detection attributed to hydrophobic interaction. -- Highlights: • This study investigates the heavy-atom effect (HAE) on aggregation-induced emission enhancement (AIEE) properties of salicylaldehyde azines. • Chloro- and bromo-salicylaldehyde display typical AIEE properties of salicylaldehyde azine, whereas the iodo-substitute quenches AIEE in aggregated state. • Iodo-salicylaldehyde can be applied as a turn-on fluorescence probe for egg albumin detection attributed to hydrophobic interaction.

  7. Synthesis of 2H-Chromenones from Salicylaldehydes and Arylacetonitriles

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    Chengcai Li

    2017-07-01

    Full Text Available An efficient and convenient protocol for the synthesis of 2H-chromenones has been developed. In the presence of tBuOK in DMF, good to excellent yields of various chromenones were obtained from the corresponding salicylaldehydes and arylacetonitriles. No protection of inert gas atmosphere is required here.

  8. New oxozirconium(IV) complexes with the schiff bases derived from salicylaldehyde or substituted salicylaldehydes and o-aminobenzyl alcohol

    International Nuclear Information System (INIS)

    Syamal, A.; Kumar, D.

    1980-01-01

    Several new oxozirconium(IV) complexes with the schiff bases obtained from salicylaldehyde, 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde, 5-nitrosalicylaldehyde, 4-methoxysalicylaldehyde, 5-methoxysalicylaldehyde, 3-ethoxysalicylaldehyde, 3, 5-dichlorosalicylaldehyde or 2-hydroxy-1-naphthaldehyde and 0-aminobenzyl alcohol have been synthesized and characterized on the basis of elementel analysis, molecular weight, electrical conductance, infrared spectral and magnetic susceptibility measurements. The schiff bases behave as monobasic, tridentate ONO donor ligands. The complexes are of the type ZrO(LH) 2 (where LH 2 = tridentate schiff base) and are seven-coordinated. The complexes are monomers, non-electrolytes and diamagnetic. Changes in the νC=N, νC-0 (phenolic) and νC-0 (alchoholic) frequencies have been followed to find out the coordination sites of the ligands. (author)

  9. Mixed-ligand complexes of zirconium (IV) and uranium with salicylaldehyde and some heterocyclic azopyrazolones

    International Nuclear Information System (INIS)

    Amrallahi, A.H.

    1994-01-01

    Mixed-ligand complexes of Zr(IV) and U(IV) with salicylaldehyde (SA) and some heterocyclic azopyrazolenes have been studied spectrophotometrically. All formed chelates have ratio 1:1:1. The stoichiometry and stability of the binary mixed chelates been evaluated. Elemental analysis, molar conductance and IR spectra have been used for identification of solid mixed complexes. (author)

  10. Synthesis, characterisation and thermal properties of dioxouranium(VI) complexes of salicylaldehyde Schiff bases

    International Nuclear Information System (INIS)

    Thomas, Rosamma; Thomas, J.K.; Parameswaran, Geetha

    1996-01-01

    Coordination ability of different Schiff bases derived from salicylaldehyde and their analytical applications have been studied extensively. The results of spectroscopic and thermal investigations of some dioxouranium(VI) complexes of four Schiff base ligands are reported. 8 refs., 2 tabs

  11. Copper-catalyzed oxidative coupling of formamides with salicylaldehydes: synthesis of carbamates in the presence of a sensitive aldehyde group.

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    Barve, Balaji D; Wu, Yang-Chang; El-Shazly, Mohamed; Chuang, Da-Wei; Cheng, Yuan-Bin; Wang, Jeh-Jeng; Chang, Fang-Rong

    2014-04-04

    A diverse library of novel carbamates was synthesized utilizing copper-catalyzed oxidative C-O coupling of formamides and salicylaldehydes. Sensitive aldehyde groups remained intact in the presence of an oxidant and a transition-metal salt. Salicylaldehydes bearing electron-donating, electron-withdrawing, and halogen groups as well as 1-hydroxy-2-naphthaldehydes provided the desired carbamates in good to excellent yields.

  12. Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides.

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    Backes, Gregory L; Neumann, Donna M; Jursic, Branko S

    2014-09-01

    Efficient synthetic procedures for the preparation of acid hydrazines and hydrazides were developed by converting the corresponding carboxylic acid into the methyl ester catalyzed by Amberlyst-15, followed by a reaction with hydrazine monohydrate. Sulfohydrazides were prepared from the corresponding sulfonyl chlorides and hydrazine monohydrate. Both of these group of compounds were condensed with substituted salicylaldehydes using gradient concentration methods that generated a large library of hydrazone, hydrazide and sulfohydrazide analogs. Antifungal activity of the prepared analogs showed that salicylaldehyde hydrazones and hydrazides are potent inhibitors of fungal growth with little to no mammalian cell toxicity, making these analogs promising new targets for future therapeutic development. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Iron(III) and aluminium(III) complexes with substituted salicyl-aldehydes and salicylic acids.

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    Nurchi, Valeria M; Crespo-Alonso, Miriam; Toso, Leonardo; Lachowicz, Joanna I; Crisponi, Guido; Alberti, Giancarla; Biesuz, Raffaela; Domínguez-Martín, Alicia; Niclós-Gutíerrez, Juan; González-Pérez, Josefa M; Zoroddu, M Antonietta

    2013-11-01

    The chelating properties toward iron(III) and aluminium(III) of variously substituted salicyl-aldehydes and salicylic acids have been evaluated, together with the effect of methoxy and nitro substituents in ortho and para position with respect to the phenolic group. The protonation and iron and aluminium complex formation equilibria have been studied by potentiometry, UV-visible spectrophotometry and (1)H NMR spectroscopy. The overall results highlight that salicyl-aldehydes present good chelating properties toward iron(III), with pFe ranging from 14.2 with nitro to 15.7 with methoxy substituent, being ineffective toward aluminium; the pFe values for salicylic acids are generally lower than those for salicyl-aldehydes, and about 4 units higher than the corresponding pAl values. The effect of the two substituents on the chelating properties of the ligands can be rationalized in terms of the Swain-Lupton treatment which accounts for the field and resonance effects. The structural characterization of the 1:2 iron complex with p-nitro salicylic acid shows that iron(III) ion exhibits an octahedral surrounding where two salicylate chelating ligands supply two O-phenolate and two O-carboxylate donor atoms in a roughly equatorial plane. The trans-apical sites are occupied by two aqua ligands. © 2013.

  14. Spectroscopic analyses on interaction of Amantadine-Salicylaldehyde, Amantadine-5-Chloro-Salicylaldehyde and Amantadine-o-Vanillin Schiff-Bases with bovine serum albumin (BSA)

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    Wang, Zhiqiu; Gao, Jingqun; Wang, Jun; Jin, Xudong; Zou, Mingming; Li, Kai; Kang, Pingli

    2011-12-01

    In this work, three Tricyclo [3.3.1.1(3,7)] decane-1-amine (Amantadine) Schiff-Bases, Amantadine-Salicylaldehyde (AS), Amantadine-5-Chloro-Salicylaldehyde (AS-5-C) and Amantadine-o-Vanillin (AS-o-V), were synthesized by direct heating reflux method in ethanol solution and characterized by infrared spectrum and elementary analysis. Fluorescence quenching was used to study the interaction of these Amantadine Schiff-Bases (AS, AS-5-C and AS-o-V) with bovine serum albumin (BSA). According to fluorescence quenching calculations the bimolecular quenching constant ( Kq), apparent quenching constant ( KSV), effective binding constant ( KA) and corresponding dissociation constant ( KD), binding site number ( n) and binding distance ( r) were obtained. The results show that these Amantadine Schiff-Bases can obviously bind to BSA molecules and the binding strength order is AS < AS-5-C = AS-o-V. Synchronous fluorescence spectroscopy reveals that these Amantadine Schiff-Bases adopt different way to bind with BSA molecules. That is, the AS and AS-5-C are accessibility to tryptophan (Trp) residues more than the tyrosine (Tyr) residues, while the AS-o-V is equally close to the Tyr and Trp residues.

  15. The stereochemistry of the condensation product of salicylaldehyde and n-butylbarbituric acid by NMR techniques

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    Cruz, Elizabete R.; Villar, J. Daniel Figueroa [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil). Dept. de Quimica

    1995-12-31

    Since the discovery of the 5-deazaflavin cofactor (coenzyme F{sub 420}) as a naturally occurring compound, a great attention has been focused on several iso steric flavin analogues. One of the simplest approaches towards the synthesis of oxadeazaflavin, compound which the nitrogen at the N-10 position of 5-deazaflavin is replaced by oxygen, is the direct condensation between barbituric acid and salicylaldehyde. In this paper, the use of some NMR techniques so as to determine the stereochemistry of the preformed isomer has been described and a possible mechanism for this isomerization discussed 12 refs., 2 figs., 1 tab.

  16. The use of domestic microwave oven in experimental classes of organic chemistry: salicylaldehyde nitration

    International Nuclear Information System (INIS)

    Teixeira, Eurides Francisco; Santos, Ana Paula Bernardo dos; Bastos, Renato Saldanha; Pinto, Angelo C.

    2010-01-01

    The use of microwave in chemistry has known benefits over conventional heating methods, e.g. reduced reaction times, chemical yield improvement and the possibility if reducing or eliminating the use of organic solvents. We describe herein a procedure for the nitration of salicylaldehyde in water using a domestic microwave oven, which can be used as an experiment in the undergraduate chemistry laboratory. The experiment involves safe and rapid preparation and identification of the position isomers by thin layer chromatography and 1 H NMR, or by their melting points. (author)

  17. Copper(II) complexes of salicylaldehyde hydrazones: synthesis, structure, and DNA interaction.

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    Wu, La-Mei; Teng, Han-Bing; Ke, Xian-Bing; Xu, Wen-Jin; Su, Jiang-Tao; Liang, Shu-Cai; Hu, Xian-Ming

    2007-09-01

    Three hydrazone ligands, H2L1-H2L3, made from salicylaldehyde and ibuprofen- or naproxen-derived hydrazides, were prepared and transformed into the corresponding copper(II) complexes [Cu(II)L1] x H2O, [Cu(II)L2], and [(Cu(II))2(L3)2] x H2O x DMF (Scheme). The X-ray crystal structure of the last-mentioned complex was solved (Fig. 1), showing a square-planar complexation geometry, and the single units were found to form a one-dimensional chain structure (Fig. 2). The interactions of these complexes with CT-DNA were studied by different techniques, indicating that they all bind to DNA by classical and/or non-classical intercalation modes.

  18. Crystal and molecular structure of uranium (6) complex with salicylaldehyde S-methyl-isothiosemicarbazone

    International Nuclear Information System (INIS)

    Chuguryan, D.G.; Dzyubenko, V.I.; Grigor'ev, M.S.; Yanovskij, A.I.; Struchkov, Yu.T.; Gehrbehlehu, N.V.; Revenko, M.D.

    1988-01-01

    Uranyl complex with salicylaldehyde S-methyl-isothiosemicarbazone (H 2 Q) of (UO 2 xHQxOCH 3 ) 2 composition is synthesized and investigated by X-ray structural analysis. Crystal is monoclinic: a=1.0334 (4), b1.0484 (5), c=1.2560 (4) nm, β=90.61 (3) deg, V=1.361 nm 3 , z=4 allouring for dimer, ρ calc =2.43 g/cm 3 , space group Ρ 1 /c. Uranium coordination number equals to 7. Distorted pentagonal coordination of each uranium atom in equatorial plane of molecucular complexes realizes due to 2N and O set of HQ donor atoms and of two oxygen atoms of methoxy-groups. While methoxy-groups behave as bridging ones, binding complex molecules in dimer. The shortest intermolecular contact between dimers corresponds only to rather weak H-bond; dimers are bonded in crystal lattice mainly by van-der-waals interaction

  19. A Novel Pregabalin Functionalized Salicylaldehyde Derivative Afforded Prospective Pain, Inflammation, and Pyrexia Alleviating Propensities.

    Science.gov (United States)

    Ahmad, Nisar; Subhan, Fazal; Islam, Nazar Ul; Shahid, Muhammad; Rahman, Faiz Ur; Fawad, Khwaja

    2017-06-01

    A novel pregabalin derivative named as pregsal ((S,E)-3-(((2-hydroxybenzylidene)amino)methyl)-5-methylhexanoic acid) was synthesized by a simple imination reaction between pregabalin and salicylaldehyde and was evaluated in the in vivo testing paradigms. The compound was characterized by UV, IR, 1 H, 13 C NMR, HR ESI-MS, and elemental analysis. It was screened (30, 50, 75, and 100 mg/kg) for antinociceptive, anti-inflammatory, and antipyretic activities in relation to pregabalin. The synthesized compound significantly attenuated the tonic acetic acid-induced nociceptive pain (30 mg/kg (P pain, inflammation, and pyrexia relieving propensities and therefore may serve as a potential drug candidate for the therapeutic management of chronic pain conditions. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Antibacterial activity of Pd(II) complexes with salicylaldehyde-amino acids Schiff bases ligands.

    Science.gov (United States)

    Rîmbu, Cristina; Danac, Ramona; Pui, Aurel

    2014-01-01

    Palladium(II) complexes with Schiff bases ligands derived from salicylaldehyde and amino acids (Ala, Gly, Met, Ser, Val) have been synthesized and characterized by Fourier transform (FT)-IR, UV-Vis and (1)H-NMR spectroscopy. The electrospray mass spectrometry (ES-MS) spectrometry confirms the formation of palladium(II) complexes in 1/2 (M/L) molar ratio. All the Pd(II) complexes 1, [Pd(SalAla)2]Cl2; 2, [Pd(SalGly)2]Cl2; 3, [Pd(SalMet)2]Cl2; 4, [Pd(SalSer)2]Cl2; 5, [Pd(SalVal)2]Cl2; have shown antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli.

  1. Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes.

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    Mikhed, Yuliya; Bruns, Kai; Schildknecht, Stefan; Jörg, Michael; Dib, Mobin; Oelze, Matthias; Lackner, Karl J; Münzel, Thomas; Ullrich, Volker; Daiber, Andreas

    2016-04-01

    There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine. Previous data showed that at nanomolar fluxes of peroxynitrite, nitration of these phenolic compounds was outcompeted by dimerization (e.g. biphenols or dityrosine). Using 3-morpholino sydnonimine (Sin-1), we created low fluxes of peroxynitrite in our reaction set-up to demonstrate that salicylaldehyde displays unique features in the detection of physiological fluxes of peroxynitrite, yielding detectable nitration but only minor dimerization products. By means of HPLC analysis and detection at 380nm we could identify the expected nitration products 3- and 5-nitrosalicylaldehyde, but also novel nitrated products. Using mass spectrometry, we also identified 2-nitrophenol and a not fully characterized nitrated dimerization product. The formation of 2-nitrophenol could proceed either by primary generation of a phenoxy radical, followed by addition of the NO2-radical to the various resonance structures, or by addition of the peroxynitrite anion to the polarized carbonyl group with subsequent fragmentation of the adduct (as seen with carbon dioxide). Interestingly, we observed almost no 3- and 5-nitrosalicylic acid products and only minor dimerization reaction. Our results disagree with the previous general assumption that nitration of low molecular weight phenolic compounds is always outcompeted by dimerization at nanomolar peroxynitrite fluxes and highlight unique features of salicylaldehyde as a probe for physiological concentrations of peroxynitrite. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  2. Facile, mild and convenient preparation and characterization of some novel Schiff base ligands from synthetic diamines and salicylaldehyde

    OpenAIRE

    H. Naeimi; A. Heidarnezhad

    2015-01-01

    Some novel Schiff base ligands have been prepared through condensation of salicylaldehyde with synthetic various primary diamines under mild reaction conditions. The used aromatic diamines were synthesized in good yields starting from low-cost commercially available materials. In these reactions, the Schiff base products have been afforded with excellent yields and appropriate reaction times. The structure of these ligands has been characterized by IR, 1H NMR and 13C NMR techniques. DOI: http...

  3. Interaction of dinuclear cadmium(II) 5-Cl-salicylaldehyde complexes with calf-thymus DNA

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    Ristovic, Maja Sumar [Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki (Greece); Faculty of Chemistry, University of Belgrade, Studenski Trg 12-16, Belgrade (Serbia); Zianna, Ariadni; Psomas, George; Hatzidimitriou, Antonios G. [Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki (Greece); Coutouli-Argyropoulou, Evdoxia [Department of Organic Chemistry and Biochemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki (Greece); Lalia-Kantouri, Maria, E-mail: lalia@chem.auth.gr [Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki (Greece)

    2016-04-01

    Five dinuclear Cd(II) complexes with the anion of 5-Cl-salicylaldehyde (5-Cl-saloH) were synthesized in the absence or presence of the α-diimines: 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-phenanthroline (neoc) or 2,2′-dipyridylamine (dpamH) and characterized as [Cd(5-Cl-salo){sub 2}(CH{sub 3}OH)]{sub 2} (1), [Cd(5-Cl-salo){sub 2}(bipy)]{sub 2} (2), [Cd(5-Cl-salo){sub 2}(phen)]{sub 2} (3), [Cd(5-Cl-salo)(neoc)(ONO{sub 2})]{sub 2} (4) and [Cd(5-Cl-salo)(dpamΗ)(ONO{sub 2})]{sub 2} (5). The complexes were characterized by spectroscopic techniques (IR, UV‐vis, {sup 1}H-NMR and {sup 13}C–NMR), elemental analysis and molar conductivity measurements. The structures of four complexes (1–3 and 5) were determined by X-ray crystallography, providing all three possible coordination modes of the ligand 5-Cl-salicylaldehyde, i.e. bidentate or tridentate chelating and/or bridging mode. The complexes bind to calf-thymus (CT) DNA mainly by intercalation, as concluded by the viscosity measurements and present relatively high DNA-binding constants. The complexes exhibit significant ability to displace ethidium bromide (EB) from the EB-DNA complex, thus indirectly proving the intercalation as the most possible binding mode to CT DNA. - Graphical abstract: Cadmium complexes of the formulae [Cd(5-Cl-salo){sub 2}(CH{sub 3}OH)]{sub 2} and [Cd(5-Cl-salo){sub 2}(α-diimine)]{sub 2} or [Cd(5-Cl-salo)(α-diimine)(ONO{sub 2})]{sub 2} have been synthesized and characterized. The complexes bind tightly to CT DNA probably by intercalation competing with ethidium bromide for the intercalation site of DNA. - Highlights: • Synthesis of a series of dinuclear Cd complexes • The complexes characterized by diverse techniques. • The crystal structures of four complexes have been determined. • Intercalation is the most possible binding mode of the complexes to DNA. • The complexes compete with ethidium bromide for the DNA-intercalating sites.

  4. Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease.

    Science.gov (United States)

    Rogolino, Dominga; Bacchi, Alessia; De Luca, Laura; Rispoli, Gabriele; Sechi, Mario; Stevaert, Annelies; Naesens, Lieve; Carcelli, Mauro

    2015-10-01

    The influenza virus PA endonuclease is an attractive target for the development of novel anti-influenza virus therapeutics, which are urgently needed because of the emergence of drug-resistant viral strains. Reported PA inhibitors are assumed to chelate the divalent metal ion(s) (Mg²⁺ or Mn²⁺) in the enzyme's catalytic site, which is located in the N-terminal part of PA (PA-Nter). In the present work, a series of salicylaldehyde thiosemicarbazone derivatives have been synthesized and evaluated for their ability to inhibit the PA-Nter catalytic activity. Compounds 1-6 have been evaluated against influenza virus, both in enzymatic assays with influenza virus PA-Nter and in virus yield assays in MDCK cells. In order to establish a structure-activity relationship, the hydrazone analogue of the most active thiosemicarbazone has also been evaluated. Since chelation may represent a mode of action of such class of molecules, we studied the interaction of two of them, one with and one without biological activity versus the PA enzyme, towards Mg²⁺, the ion that is probably involved in the endonuclease activity of the heterotrimeric influenza polymerase complex. The crystal structure of the magnesium complex of the o-vanillin thiosemicarbazone ligand 1 is also described. Moreover, docking studies of PA endonuclease with compounds 1 and 2 were performed, to further analyse the possible mechanism of action of this class of inhibitors.

  5. Synthesis, characterization and biological assay of Salicylaldehyde Schiff base Cu(II) complexes and their precursors

    Science.gov (United States)

    Iftikhar, Bushra; Javed, Kanwal; Khan, Muhammad Saif Ullah; Akhter, Zareen; Mirza, Bushra; Mckee, Vickie

    2018-03-01

    Three new Schiff base ligands were synthesized by the reaction of Salicylaldehyde with semi-aromatic diamines, prepared by the reduction of corresponding dinitro-compounds, and were further used for the formation of complexes with Cu(II) metal ion. The structural features of the synthesized compounds were confirmed by their physical properties and infrared, electronic and NMR spectroscopic techniques. The studies revealed that the synthesized Schiff bases existed as tetradentate ligands and bonded to the metal ion through the phenolic oxygen and azomethine nitrogen. One of the dinitro precursors was also analyzed by single crystal X-ray crystallography, which showed that it crystallizes in monoclinic system with space group P2/n. The thermal behavior of the Cu(II) complexes was determined by thermogravimetric analysis (TGA) and kinetic parameters were evaluated from the data. Schiff base ligands, their precursors and metal complexes were also screened for antibacterial, antifungal, antitumor, Brine shrimp lethality, DPPH free radical scavenging and DNA damage assays. The results of these analyses indicated the substantial potential of the synthesized Schiff bases, their precursors and Cu(II) complexes in biological field as future drugs.

  6. Tin(II Selective PVC Membrane Electrode Based on Salicylaldehyde Thiosemicarbazone as an Ionophore

    Directory of Open Access Journals (Sweden)

    Sulekh Chandra

    2013-01-01

    Full Text Available A polymeric membrane-based tin selective electrode was developed by using salicylaldehyde thiosemicarbazone (STSC. The best performance was recorded with a membrane composition of PVC : TBP : ionophore : NaTPB as 28 : 59 : 8 : 5 (w/w%. The Nernstian slope calculated from the calibration curve for Sn2+ sensor was 28.8 ± 0.4 mV/decade. The detection limit of the sensor was 2.10 × 10−8 M, in the linear concentration range of 1.0 × 10−2−1.1 × 10−7 M. It was relatively fast response time (<8 s for concentration ≥1.0×10−4 and <12 s for concentration of ≥1.0×10−6 M and can be used for 9 months without any considerable divergence in potentials. The proposed sensor exhibit relatively good selectivity and high sensitivity for tin(II as other mono-, di-, and trivalent cations and can be used in a pH range of 2.0–8.5. The analytical usefulness of the proposed electrode has been evaluated by its application in the determination of stannous in artificially made samples.

  7. Study on interaction between salicylaldehyde l-serine schiff base and human serum albumin by fluorescence spectroscopy

    Directory of Open Access Journals (Sweden)

    Yang Yanqiu

    2017-01-01

    Full Text Available The interaction of salicylaldehyde L-serine Schiff base (L with human serum albumin (HSA was examined by fluorescence emission spectra at the excitation wavelength 290 nm. Through fluorescence quenching experiments, it was confirmed that the combination of L with HSA was static quenching process. Thermodynamic parameters, such as ΔG, ΔH and ΔS, were calculated at different temperatures, showing that van der Waals force or hydrogen bond interaction were mostly responsible for the binding of L to HSA. The experiments results showed that the microenvironment and the conformation of HSA changed during the binding reaction.

  8. Facile, mild and convenient preparation and characterization of some novel Schiff base ligands from synthetic diamines and salicylaldehyde

    Directory of Open Access Journals (Sweden)

    H. Naeimi

    2015-01-01

    Full Text Available Some novel Schiff base ligands have been prepared through condensation of salicylaldehyde with synthetic various primary diamines under mild reaction conditions. The used aromatic diamines were synthesized in good yields starting from low-cost commercially available materials. In these reactions, the Schiff base products have been afforded with excellent yields and appropriate reaction times. The structure of these ligands has been characterized by IR, 1H NMR and 13C NMR techniques. DOI: http://dx.doi.org/10.4314/bcse.v29i1.10

  9. Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells.

    Science.gov (United States)

    Caro, Andres A; Commissariat, Ava; Dunn, Caroline; Kim, Hyunjoo; García, Salvador Lorente; Smith, Allen; Strang, Harrison; Stuppy, Jake; Desrochers, Linda P; Goodwin, Thomas E

    2015-11-01

    Salicylaldehyde isonicotinoyl hydrazone (SIH) is an iron chelator of the aroylhydrazone class that displays antioxidant or prooxidant effects in different mammalian cell lines. Because the liver is the major site of iron storage, elucidating the effect of SIH on hepatic oxidative metabolism is critical for designing effective hepatic antioxidant therapies. Hepatocyte-like HepG2 cells were exposed to SIH or to analogs showing greater stability, such as N'-[1-(2-Hydroxyphenyl)ethyliden]isonicotinoyl hydrazide (HAPI), or devoid of iron chelating properties, such as benzaldehyde isonicotinoyl hydrazone (BIH), and toxicity, oxidative stress and antioxidant (glutathione) metabolism were evaluated. Autoxidation of Fe(2+)in vitro increased in the presence of SIH or HAPI (but not BIH), an effect partially blocked by Fe(2+) chelation. Incubation of HepG2 cells with SIH or HAPI (but not BIH) was non-toxic and increased reactive oxygen species (ROS) levels, activated the transcription factor Nrf2, induced the catalytic subunit of γ-glutamate cysteine ligase (Gclc), and increased glutathione concentration. Fe(2+) chelation decreased ROS and inhibited Nrf2 activation, and Nrf2 knock-down inhibited the induction of Gclc in the presence of HAPI. Inhibition of γ-glutamate cysteine ligase enzymatic activity inhibited the increase in glutathione caused by HAPI, and increased oxidative stress. SIH iron chelators display both prooxidant (increasing the autoxidation rate of Fe(2+)) and antioxidant (activating Nrf2 signaling) effects. Activation by SIH iron chelators of a hormetic antioxidant response contributes to their antioxidant properties and modulates the anti- and pro-oxidant balance. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Synthesis, crystal structure and biological activity of the Schiff base organotin(IV) complexes based on salicylaldehyde-o-aminophenol

    Science.gov (United States)

    Tan, Yu-Xing; Zhang, Zhi-Jian; Liu, Yang; Yu, Jiang-Xi; Zhu, Xiao-Ming; Kuang, Dai-Zhi; Jiang, Wu-Jiu

    2017-12-01

    Schiff base organotin(IV) complexes C1 ∼ C5b have been synthesized via the reaction of the substituted salicylaldehyde-o-aminophenol Schiff base ligands (L1 ∼ L3) with the dibenzyltin dichloride, n-butyltin trichloride or dibutyltin oxide, respectively. The complexes have been characterized by IR, UV-Vis, 1H NMR, 13C NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. The anticancer activity of the Schiff base ligand and complexes C1 ∼ C5b against five species of cancer cell which are Hela, MCF7, HepG2, Colo205, NCIsbnd H460 were tested respectively, the tests showed that C1 ∼ C5b exhibited significant anticancer activity for the cancer cells in comparison with the ligand, and the activity was greater than carboplatin.

  11. Colorimetric and fluorimetric response of salicylaldehyde dithiosemicarbazone towards fluoride, cyanide and copper ions: Spectroscopic and TD-DFT studies.

    Science.gov (United States)

    Harikrishnan, Vengayil K; Basheer, Sabeel M; Joseph, Nithin; Sreekanth, Anandaram

    2017-07-05

    The sensing mechanism of salicylaldehyde phenyldithiosemicarbazone (SDTSC) chemosensor has been investigated by spectroscopic and TD-DFT methods. The SDTSC shows colourimetric and spectral changes towards fluoride, cyanide and copper ions. The interaction between SDTSC with fluoride, cyanide and copper ions was examined through their absorption and fluorescence behaviour, and found that SDTSC has more sensing ability towards Cu 2+ ion than CN - and F - ions. The 1 H NMR titration with SDTSC and F - gives the structural changes in the sensing process. The reversibility of SDTSC was also evaluated and thus it is confirmed as a reusable chemosensor which can be clarified by the "Read-Erase-Read-Write" logic system. The DFT and TD-DFT calculations give the detailed sensing mechanism of SDTSC towards fluoride ion. The potential energy surface (PES) analysis confirms the excited state electron transfer mechanism. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde

    Directory of Open Access Journals (Sweden)

    Volodymyr V. Tkachenko

    2014-12-01

    Full Text Available The switchable three-component reactions of 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides under different conditions were studied and discussed. The unexpected influence of the aryl substituent in N-aryl-3-oxobutanamides on the behavior of the reaction was discovered. The key influence of ultrasonication and Lewis acid catalysts led to an established protocol to selectively obtain two or three types of heterocyclic scaffolds depending on the substituent in the N-aryl moiety.

  13. New turn-on fluorescent and colorimetric probe for cyanide detection based on BODIPY-salicylaldehyde and its application in cell imaging

    International Nuclear Information System (INIS)

    Sukato, Rangsarit; Sangpetch, Nuanphan; Palaga, Tanapat; Jantra, Suthikorn; Vchirawongkwin, Viwat; Jongwohan, Chanantida; Sukwattanasinitt, Mongkol; Wacharasindhu, Sumrit

    2016-01-01

    Highlights: • A novel salicylaldehyde-BODIPY fluorescent sensor is prepared. • The sensor shows dual colorimetric & turn-on fluorescence response to cyanide ion. • Detection limit is 0.88 μM (below WHO standard for drinking water). • It is effective for cyanide detection an in vitro cellular system. - Abstract: Development of cyanide sensor is important as the anion is harmful to human health and the environment. Herein, a new colorimetric and fluorescent probe GSB based on boron dipyrrole-methene (BODIPY) containing salicylaldehyde group for cyanide detection has been reported. GSB undergoes exclusive colorimetric change from orange to colorless and exhibits selective fluorescence turn-on at 504 nm upon the addition of cyanide. Other 13 anions give almost no interference under physiological condition. Detection limit of the new cyanide-sensing GSB is 0.88 μM, which is below World Health Organization (WHO) recommended level in drinking water. A calculation by density functional theory (DFT) shows suppression of photoinduced electron transfer (PET) mechanism along with the interruption of π-conjugation between salicylaldehyde and BODIPY core by cyanide anion. Cell imaging studies demonstrated that GSB is compatible and capable of sensing cyanide anion in living cells.

  14. New turn-on fluorescent and colorimetric probe for cyanide detection based on BODIPY-salicylaldehyde and its application in cell imaging

    Energy Technology Data Exchange (ETDEWEB)

    Sukato, Rangsarit [Program of Petrochemistry and Polymer Science, Chulalongkorn University, Bangkok 10330 (Thailand); Sangpetch, Nuanphan; Palaga, Tanapat [Department of Microbiology, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330 (Thailand); Jantra, Suthikorn; Vchirawongkwin, Viwat; Jongwohan, Chanantida [Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330 (Thailand); Sukwattanasinitt, Mongkol [Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330 (Thailand); Wacharasindhu, Sumrit, E-mail: sumrit.w@chula.ac.th [Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330 (Thailand)

    2016-08-15

    Highlights: • A novel salicylaldehyde-BODIPY fluorescent sensor is prepared. • The sensor shows dual colorimetric & turn-on fluorescence response to cyanide ion. • Detection limit is 0.88 μM (below WHO standard for drinking water). • It is effective for cyanide detection an in vitro cellular system. - Abstract: Development of cyanide sensor is important as the anion is harmful to human health and the environment. Herein, a new colorimetric and fluorescent probe GSB based on boron dipyrrole-methene (BODIPY) containing salicylaldehyde group for cyanide detection has been reported. GSB undergoes exclusive colorimetric change from orange to colorless and exhibits selective fluorescence turn-on at 504 nm upon the addition of cyanide. Other 13 anions give almost no interference under physiological condition. Detection limit of the new cyanide-sensing GSB is 0.88 μM, which is below World Health Organization (WHO) recommended level in drinking water. A calculation by density functional theory (DFT) shows suppression of photoinduced electron transfer (PET) mechanism along with the interruption of π-conjugation between salicylaldehyde and BODIPY core by cyanide anion. Cell imaging studies demonstrated that GSB is compatible and capable of sensing cyanide anion in living cells.

  15. Transition metal complexes with thiosemicarbazide-based ligands. Part46. Synthesis and physico-chemical characterization of mixed ligand cobalt(III-complexes with salicylaldehyde semi-, thiosemi- and isothiosemicarbazone and pyridine

    Directory of Open Access Journals (Sweden)

    VUKADIN M. LEOVAC

    2003-12-01

    Full Text Available Mixed ligand octahedral cobalt(III complexes with the tridentate salicylaldehyde semi-, thiosemi- and isothiosemicarbazone and pyridine of general formula [CoIII(L11-3(py3]X (H2L1 = salicylaldehyde semicarbazone, X = [CoIICl3(py]-, ClO4- . H2O, I- . 0.5 I2; H2L2 = salicylaldehyde thiosemicarbazone, X = [CoIICl3(py]-, [CoIIBr3(py]-, ClO4- . H2O, I3-; H2L3 = salicylaldehyde S-methylisothiosemicarbazone, X = [ CoIIBr3(py ]-, ClO4- . H2O, BF4- were synthesized. The tridentate coordination of all the three dianionic forms of the ligands involves the phenol oxygen, hydrazine nitrogen and the chalcogen (O or S in case of salicylaldehyde semi-, thiosemicarbazone and the terminal nitrogen atom in the case of isothiosemicarbazone. For all the complexes, a meridial octahedral arrangement is proposed, which is a consequence of the planarity of the chelate ligand. The compounds were characterized by elemental analysis, molar conductivity, magnetic susceptibility, IR and electronic absorption spectra. The thermal decomposition of the complexes was investigated by thermogravimetry, coupled TG-MS measurements and DSC.

  16. Elucidating Latent Mechanistic Complexity in Competing Acid-Catalyzed Reactions of Salicylaldehyde-Derived Baylis-Hillman Adducts.

    Science.gov (United States)

    Olomola, Temitope O; Klein, Rosalyn; Caira, Mino R; Kaye, Perry T

    2016-01-04

    (1)H NMR-based kinetic studies have revealed the latent mechanistic complexity of deceptively simple hydrochloric acid-catalyzed reactions of salicylaldehyde-derived Baylis-Hillman adducts. Reactions conducted at 0 °C afforded 2-(chloromethyl)cinnamic acid derivatives as the major products and the corresponding 3-(chloromethyl)coumarin derivatives as the minor products. In reactions conducted in refluxing acetic acid, however, the 3-(chloromethyl)coumarin derivatives are the sole products. Variable-temperature (1)H NMR analysis permitted the determination of the rate constants and kinetic parameters involved in the pseudo-first-order formation of (Z)-2-(chloromethyl)-3-(2-hydroxyphenyl)-2-propenoic acid. The kinetic data clearly preclude the operation of classical kinetic versus thermodynamic control and indicate the operation of three independent reaction pathways. Theoretical studies of these pathways undertaken at the B3LYP/6-31G(d) level permitted rationalization of the experimental data and provided insights into the possible mechanism of the enzymic E-Z isomerization and cyclization of (E)-cinnamic acid analogues to afford coumarins.

  17. Mixed ligand complexes of alkaline earth metals: Part XII. Mg(II, Ca(II, Sr(II and Ba(II complexes with 5-chlorosalicylaldehyde and salicylaldehyde or hydroxyaromatic ketones

    Directory of Open Access Journals (Sweden)

    MITHLESH AGRAWAL

    2002-04-01

    Full Text Available The reactions of alkaline earth metal chlorides with 5-chlorosalicylaldehyde and salicylaldehyde, 2-hydroxyacetophenone or 2-hydroxypropiophenone have been carried out in 1 : 1 : 1 mole ratio and the mixed ligand complexes of the type MLL’(H2O2 (where M = Mg(II, Ca(II, Sr(II and Ba(II, HL = 5-chlorosalicylaldehyde and HL’ = salicylaldehyde, 2-hydroxyacetophenone or 2-hydroxypropiophenone have been isolated. These complexes were characterized by TLC, conductance measurements, IR and 1H-NMR spectra.

  18. Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture.

    Science.gov (United States)

    Baker, E; Richardson, D; Gross, S; Ponka, P

    1992-03-01

    A range of new analogues of the promising iron chelator pyridoxal isonicotinoyl hydrazone was prepared and assessed for activity in reducing hepatocyte iron, mechanism of action and potential in iron-chelation therapy. A total of 45 compounds were synthesized by condensation of aromatic aldehydes (pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde) with various acid hydrazides prepared by systematic substitutions on the benzene ring or by the replacement of the ring with an acetyl, pyridyl, furoyl or thiophene moiety. The effects of these compounds on 59Fe uptake and intracellular distribution in hepatocytes in culture and on 59Fe mobilization from prelabeled hepatocytes were assessed. Toxicity, lipophilicity and the ability to chelate plasma transferrin-bound 59Fe were also evaluated. Several compounds were much more active than pyridoxal isonicotinoyl hydrazone and may have clinical potential. These included pyridoxal benzoyl hydrazone, pyridoxal p-methoxybenzoyl hydrazone, pyridoxal m-fluorobenzoyl hydrazone and pyridoxal 2-pyridyl hydrazone. All were more effective at reducing iron uptake than mobilizing hepatocyte iron; they also may act primarily on the transit iron pool rather than on storage iron. Other compounds (e.g., salicylaldehyde p-t-butyl-benzoyl hydrazone) redistributed ferritin-59Fe to different intracellular sites but had little net effect on hepatocyte iron levels.

  19. Synthesis, structures, spectroscopy and antimicrobial properties of complexes of copper(II) with salicylaldehyde N-substituted thiosemicarbazones and 2,2'-bipyridine or 1,10-phenanthroline.

    Science.gov (United States)

    Lobana, Tarlok S; Indoria, Shikha; Jassal, Amanpreet Kaur; Kaur, Harpreet; Arora, Daljit S; Jasinski, Jerry P

    2014-04-09

    Among the biometals (Cu, Co, Ni-cofactors in many enzymes), copper derivatives of O, N, S-donor salicylaldehyde thiosemicarbazones have received considerable attention owing to their potential biological applications. Eight new complexes of salicylaldehyde-N-substituted thiosemicarbazones [5-MeO-2-HO-C₆H₄-C(2)(H)N(3)-N(2)H-C(1)(S)-N(1)HR; R = Me, H2L(1); Et, H₂L(1), Ph, H₂L(3), H, H₂L(4)] with copper(II), namely, [Cu(κ(3)-O,N,S-L)( κ(2)-N,N-L')] {(L)(2-) = (L(1))(2-), L' = bipy, 1, phen, 2; (L)(2-) = (L(2))(2-), L' = bipy, 3, phen, 4; (L)(2-) = (L(3))(2-), L' = bipy, 5, phen, 6; (L)(2-) = (L(4))(2-), L' = bipy, 7, phen, 8} have been isolated. Complexes have slightly distorted square pyramidal geometry around the metal center (τ parameter = 0.243-0.357) and display weak to intense fluorescence in the region, 375-475 nm. These copper complexes have shown significant growth inhibitory activity (antimicrobial activity) against Staphylococcus aureus (MTCC740), methicillin resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae 1 (MTCC109), Shigella flexneri (MTCC1457), Pseudomonas aeruginosa (MTCC741) and Candida albicans (MTCC227). The activity against MRSA is an interesting observation as the commercially available gentamycin is found to be inactive against this bacterial strain. Specifically complex 5 formed by 5-methoxysalicylaldehyde-N-phenylthiosemicatbazone has shown novel antimicrobial activity against various bacteria and yeast investigated. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  20. Significant effect of surfactant micelles on pH dependent fluorescent off-on-off behavior of Salicylaldehyde-2,4-Dinitrophenylhydrazone

    Energy Technology Data Exchange (ETDEWEB)

    Goswami, Priyanka [Department of Chemistry, Gauhati University, Guwahati 781 014 (India); Das, Diganta K., E-mail: digkdas@yahoo.co [Department of Chemistry, Gauhati University, Guwahati 781 014 (India)

    2011-04-15

    The fluorescence response to pH of 2,4 dinitrophenolhydrazone in 1:1 CH{sub 3}OH:H{sub 2}O and micellar mediums-negatively charged sodium dodecylsulphate (SDS), positively charged cetyltrimethyl ammonium bromide (CTAB) and neutral Triton X-100 (TX-100), is reported. At pH 4.0 the fluorescence of the molecule can be switched 'on' by selecting CTAB as the solvent. At pH 6.0 if the medium is TX-100 the fluorescence is 'off', but remains 'on' for the other three solvents. At pH 8.0, fluorescence is 'on' in the solvents except CTAB. SDS and TX-100 switch the fluorescence 'on' at pH 13.0 but for the other two solvents the fluorescence is 'off'. - Research highlights: The fluorescence response to pH of Salicylaldehyde-2,4 Dinitrophenolhydrazone in 1:1 CH{sub 3}OH:H{sub 2}O and in positively charged cetyltrimethyl ammonium bromide (CTAB) micellar medium shows 'off-on-off' behavior. In negatively charged sodium dodecylsulphate (SDS) the response of fluorescence of Salicylaldehyde-2,4 Dinitrophenolhydrazone to pH is 'off-on-on' type while in neutral Triton X-100 it is 'off-on-1/2on' type. At a given pH, fluorescence of 2,4 dinitrophenolhydrazone can be made 'on' or 'off' by selecting an appropriate pH.

  1. Voltammetric study of the boric acid-salicylaldehyde-H-acid ternary system and its application to the voltammetric determination of boron.

    Science.gov (United States)

    Kajiwara, Mari; Ito, Yoshio N; Miyazaki, Yoshinobu; Fujimori, Takao; Takehara, Kô; Yoshimura, Kazuhisa

    2015-02-14

    The ternary system of boric acid, salicylaldehyde (SA) and H-acid (HA) was voltammetrically studied from kinetic and equilibrium points of view. The effect of the SA substituents was also studied by using two analogs, 5-fluorosalicylaldehyde (F-SA) and 5-methylsalicylaldehyde (Me-SA). The three cathodic peaks of Azomethine H (AzH), Azomethine H-boric acid complex (AzB), and free SA were observed in the solution containing boric acid, SA and HA. The peak potentials of AzH and SA were shifted to negative potentials with increasing pH, while the peak potential of AzB was pH-independent. This difference indicates that a proton participates in the charge-transfer steps of the AzH and SA reductions, but not in that of the AzB reduction. The formation constants for the AzB complexation were similar among all the examined analogs. In the kinetic study, the reaction rate was higher in an acidic condition for the AzH formation, but in a neutral condition for the AzB formation. The rate constants for the AzB complexes were in the order of F-SA > SA ≈ Me-SA, indicating that the fluoro group accelerates the F-AzB complexation. The AzB complexation mechanism is considered to consist of more than three steps, i.e., the pre-equilibrium of the salicylaldehyde-boric acid complex (SA-B) formation, the nucleophilic attack of HA on SA-B, and the remaining some steps to form AzB. Based on these results, the voltammetric determination method of boron using F-SA was optimized, which allowed the boron concentration to be determined within only 5 min with a 0.03 mg B dm(-3) detection limit.

  2. SYNTHESIS AND CHARACTERIZATION OF N, N'-BIS-(3 ...

    African Journals Online (AJOL)

    user

    base complexes derived from Salicylaldehyde and histidine with some divalent transition metal ions. Furthermore, Syed (1993) reported the synthesis, characterization and biological evaluation of some. Schiff base metal complexes derived from Anthranilic acid-sugar and naturally occurring amino acid-sugar. Schiff bases ...

  3. Synthesis of Two Potentially Heptadentate (N4O3 Schiff-base Ligands Derived from Condensation of Tris(3-aminopropyl-amine and Salicylaldehyde or 4-Hydroxysalicylaldehyde. Nickel(II and Copper(II Complexes of the Former Ligand

    Directory of Open Access Journals (Sweden)

    R. V. Parish

    2002-02-01

    Full Text Available Two potentially heptadentate (N4O3 tripodal Schiff-base ligands: tris(3-(salicylideneiminopropylamine (H3L1 and tris(3-(4’-hydroxysalicylideneimino-propylamine (H3L2 have been prepared and characterized by various spectroscopic methods (IR, FAB-MS, NMR. They are derived from the condensation reactions of tris(3-aminopropylamine (tpt, with 3 equivalents of either salicylaldehyde or the ringsubstituted salicylaldehyde, 4-hydroxysalicylaldehyde. The nickel(II and copper(II complexes of H3L1 were obtained from the its reactions Ni(II and Cu(II salts in absolute methanol. These complexes were studied by IR and FAB-Mass spectrometry.

  4. Non bis in idem

    OpenAIRE

    La Rosa, Anne-Marie

    2015-01-01

    Данная статья посвящена исследованию влияния уголовно-правового принципа «non bis in idem» на возможность привлечения одновременно к уголовной и административной ответственности за одно и то же деяния. На основании анализа действующего законодательства Украины приведены аргументы относительно невозможности одновременно привлекать лицо к административной и уголовной ответственности за одно и то же деяние. Также предложены критерии, по которым возможно провести разграничение между административ...

  5. Blessures Skaten (BIS): Blessurevrij skaten?

    NARCIS (Netherlands)

    Hespen, A. van; Stubbe, J.; Stege, J.

    2009-01-01

    Sportblessures: niemand zit erop te wachten, maar jaarlijks krijgen ongeveer 1,5 miljoen mensen in Nederland ermee te maken. Om effectief aan preventie te doen, is inzicht in het aantal en soort sportblessures onmisbaar. Dit kan met het web-based Blessure Informatie Systeem (BIS) van TNO Kwaliteit

  6. Molybdenum complexes of biochemical interest. New coordination complexes of oxomolybdenum(V) with the tridentate ONO donor Schiff bases derived from salicylaldehydes and ethanolamine

    Energy Technology Data Exchange (ETDEWEB)

    Syamal, A.; Niazi, M.A.B.

    1985-02-01

    New oxomolybdenum(V) complexes MoOClL (where LH/sub 2/ = Schiff base) derived from ethanolamine and salicylaldehyde, 5-chlorosalicylaldehyde, 5-bromosalicylaldehyde, 5-nitrosalicylaldehyde, 3-ethoxysalicylaldehyde and 2-hydroxy-1-naphthaldehyde have been synthesized and characterised by elemental analyses, conductance, molecular weight, I.R. and electronic spectra and magnetic measurements. The Schiff bases behave as dibasic tridentate ONO donor ligands. The complexes are non-electrolytes and dimers. The complexes exhibit subnormal magnetic moments and are involved in antiferromagnetic exchange with S = 0 ground state. The complexes exhibit electronic spectral bands at ca. 13000 and ca. 17000 cm/sup -1/ due to the transitions dsub(xy)- > dsub(xz,yz) (/sup 2/B/sub 2/- > /sup 2/E) and dsub(xy)- > dsub(x2-y2) (/sup 2/B/sub 2/- > /sup 2/B/sub 1/), respectively. The ..nu..(Mo = O) frequency of the complexes is observed in the 900-970 cm/sup -1/ region. On the basis of the magnetic susceptibility, I.R. and molecular weight data a dimetallic structure with alcoholic oxygen atoms as the bridging atoms is suggested.

  7. Vibrational spectra, molecular structure, natural bond orbital, first order hyperpolarizability, thermodynamic analysis and normal coordinate analysis of Salicylaldehyde p-methylphenylthiosemicarbazone by density functional method

    Science.gov (United States)

    Porchelvi, E. Elamurugu; Muthu, S.

    2015-01-01

    The thiosemicarbazone compound, Salicylaldehyde p-methylphenylthiosemicarbazone (abbreviated as SMPTSC) was synthesized and characterized by FTIR, FT-Raman and UV. Density functional (DFT) calculations have been carried out for the title compound by performing DFT level of theory using B3LYP/6-31++G(d,p) basis set. The molecular geometry and vibrational frequencies were calculated and compared with the experimental data. The detailed interpretation of the vibrational spectra has been carried out with aid of normal coordinate analysis (NCA) following the scaled quantum mechanical force field methodology. The electronic dipole moment (μD) and the first hyperpolarizability (βtot) values of the investigated molecule were computed using density functional theory (DFT/B3LYP) with 6-311++G(d,p) basis set. The stability and charge delocalization of the molecule was studied by natural bond orbital (NBO) analysis. Thearomaticities of the phenyl rings were studied using the standard harmonic oscillator model of aromaticity (HOMA) index. Mulliken population analysis on atomic charges is also calculated. The molecule orbital contributions are studied by density of energy states (DOSs).

  8. The interaction of taurine-salicylaldehyde Schiff base copper(II) complex with DNA and the determination of DNA using the complex as a fluorescence probe

    Science.gov (United States)

    Zhang, Xiaoyan; Wang, Yong; Zhang, Qianru; Yang, Zhousheng

    2010-09-01

    The interaction of taurine-salicylaldehyde Schiff base copper(II) (Cu(TSSB) 22+) complex with DNA was explored by using UV-vis, fluorescence spectrophotometry, and voltammetry. In pH 7.4 Tris-HCl buffer solution, the binding constant of the Cu(TSSB) 22+ complex interaction with DNA was 3.49 × 10 4 L mol -1. Moreover, due to the fluorescence enhancing of Cu(TSSB) 22+ complex in the presence of DNA, a method for determination of DNA with Cu(TSSB) 22+ complex as a fluorescence probe was developed. The fluorescence spectra indicated that the maximum excitation and emission wavelength were 389 nm and 512 nm, respectively. Under optimal conditions, the calibration graphs are linear over the range of 0.03-9.03 μg mL -1 for calf thymus DNA (CT-DNA), 0.10-36 μg mL -1 for yeast DNA and 0.01-10.01 μg mL -1 for salmon DNA (SM-DNA), respectively. The corresponding detection limits are 7 ng mL -1 for CT-DNA, 3 ng mL -1 for yeast DNA and 3 ng mL -1 for SM-DNA. Using this method, DNA in synthetic samples was determined with satisfactory results.

  9. The interaction of taurine-salicylaldehyde Schiff base copper(II) complex with DNA and the determination of DNA using the complex as a fluorescence probe.

    Science.gov (United States)

    Zhang, Xiaoyan; Wang, Yong; Zhang, Qianru; Yang, Zhousheng

    2010-09-15

    The interaction of taurine-salicylaldehyde Schiff base copper(II) (Cu(TSSB)2(2+)) complex with DNA was explored by using UV-vis, fluorescence spectrophotometry, and voltammetry. In pH 7.4 Tris-HCl buffer solution, the binding constant of the Cu(TSSB)2(2+) complex interaction with DNA was 3.49 x 10(4) L mol(-1). Moreover, due to the fluorescence enhancing of Cu(TSSB)2(2+) complex in the presence of DNA, a method for determination of DNA with Cu(TSSB)2(2+) complex as a fluorescence probe was developed. The fluorescence spectra indicated that the maximum excitation and emission wavelength were 389 nm and 512 nm, respectively. Under optimal conditions, the calibration graphs are linear over the range of 0.03-9.03 microg mL(-1) for calf thymus DNA (CT-DNA), 0.10-36 microg mL(-1) for yeast DNA and 0.01-10.01 microg mL(-1) for salmon DNA (SM-DNA), respectively. The corresponding detection limits are 7 ng mL(-1) for CT-DNA, 3 ng mL(-1) for yeast DNA and 3 ng mL(-1) for SM-DNA. Using this method, DNA in synthetic samples was determined with satisfactory results.

  10. Synthesis, characterization and biological activity of some platinum(II) complexes with Schiff bases derived from salicylaldehyde, 2-furaldehyde and phenylenediamine

    Science.gov (United States)

    Gaballa, Akmal S.; Asker, Mohsen S.; Barakat, Atiat S.; Teleb, Said M.

    2007-05-01

    Four platinum(II) complexes of Schiff bases derived from salicylaldehyde and 2-furaldehyde with o- and p-phenylenediamine were reported and characterized based on their elemental analyses, IR and UV-vis spectroscopy and thermal analyses (TGA). The complexes were found to have the general formula [Pt(L)(H 2O) 2]Cl 2· nH 2O (where n = 0 for complexes 1, 3, 4; n = 1 for complex 2. The data obtained show that Schiff bases were interacted with Pt(II) ions in the neutral form as a bidentate ligand and the oxygens rather than the nitrogens are the most probable coordination sites. Square planar geometrical structure with two coordinated water molecules were proposed for all complexes The free ligands, and their metal complexes were screened for their antimicrobial activities against the following bacterial species: E. coli, B. subtilis, P. aereuguinosa, S. aureus; fungus A. niger, A. fluves; and the yeasts C. albican, S. cervisiea. The activity data show that the platinum(II) complexes are more potent antimicrobials than the parent Schiff base ligands against one or more microorganisms.

  11. Bis(1,3-dithiole) Compounds

    DEFF Research Database (Denmark)

    Andersen, Jan Rud; Engler, E. M.; Green, D. C.

    1977-01-01

    There is described the preparation of bis-1,3-dithiole compounds (I) which are key synthetic precursors for the preparation of new polymeric metal bis(dithiolene) (i.e., II) and tetrathiafulvalene compounds (i.e., III): (Image Omitted)...

  12. BIS monitor findings during self-hypnosis.

    Science.gov (United States)

    Burkle, Christopher M; Jankowski, Christopher J; Torsher, Laurence C; Rho, Edwin H; Degnim, Amy C

    2005-12-01

    We describe BIS values for a patient undergoing breast surgery under self-hypnosis in order to access the value of global surface EEG measures occurring during this process. Following verbal consent, a BIS(TM) monitor (Aspect Medical, Newton MA) was placed and values measured while the patient performed self-hypnosis for a simple mastectomy and sentinel node biopsy. Thirty-nine minutes after incision the BIS value decreased transiently to 72 followed by several other transient decreases, the lowest of which was 59. Values remained at approximately 90 throughout most of the operative period. The BIS value returned to baseline after completion of the operation. Our findings support the hypothesis that hypnosis is a dynamic cerebral process incorporating many changes within brain activation centers and one distinct from dissociative patterns seen under anesthesia. Current algorithms employed by the BIS(TM) monitor add little to the management of patients utilizing hypnosis for analgesia.

  13. Synthesis, photoluminescence and forensic applications of blue light emitting azomethine-zinc (II complexes of bis(salicylidenecyclohexyl-1,2-diamino based organic ligands

    Directory of Open Access Journals (Sweden)

    M. Srinivas

    2017-06-01

    Full Text Available Various azomethine-zinc(II complexes (3a-c of bis(salicylidenecyclohexyl-1,2-diamino organic ligands were synthesized by one pot reaction of salicylaldehydes/2-hydroxy-1-naphthaldehyde (2 eq, cyclohexyl-1,2-diamine (1 eq and zinc acetate (1 eq in methanol solvent at reflux temperature. The synthesized complexes were characterized by FTIR, 1H NMR, and SEM. Their photophysical properties such as Photoluminescence (PL and Diffused Reflectance Spectra (DRS were studied. PL studies revealed that the emission peaks of the complexes in both solution and solid states appeared to occur at 395–600 nm and emitted blue light. The band gap energies determined from DRS were 2.98 eV (3a, 2.91 eV (3b, and 2.73 eV (3c. Based on these results, we ascertain that these Zn(II complexes can serve as a suitable non-dopant blue light emitting compound for flat panel display applications. Latent fingerprint detection study indicated that the powder compounds show good adhesion and finger ridge details without background staining. The demonstrated method can be applied to detect fingerprints on all types of smooth surfaces.

  14. Modification of gold nanoparticle loaded on activated carbon with bis(4-methoxysalicylaldehyde)-1,2-phenylenediamine as new sorbent for enrichment of some metal ions.

    Science.gov (United States)

    Karimipour, Gholamreza; Ghaedi, Mehrorang; Sahraei, Reza; Daneshfar, Ali; Biyareh, Mehdi Nejati

    2012-01-01

    In this study, a new sorbent based on the gold nanoparticle loaded in activated carbon (Au-NP-AC) was synthesized and modified by bis(4-methoxy salicylaldehyde)-1,2-phenylenediamine (BMSAPD). This sorbent, which is abbreviated as Au-NP-AC-BMSAPD, has been applied for the enrichment and preconcentration of trace amounts of Co(2+), Cu(2+), Ni(2+), Fe(2+), Pb(2+), and Zn(2+) ions in real samples. All metal ions under study were retained on the Au-NP-AC-BMSAPD sorbent by complexation of the ions with the BMSAPD ligand, providing an efficient preconcentration fashion. The retained metal ions were then eluted from the sorbent by HNO(3) and detected by flame atomic absorption spectrometry. The analytical parameters including pH, amount of ligand, and the nature of the eluent and solid phase were evaluated to obtain the optimum condition for the preconcentration factor. Following the optimum conditions, a preconcentration factor of 200 was obtained for all the metal ions under study with detection limits of 1.4-2.6 ng mL(-1). The method has been successfully applied for the extraction and determination of the ion content in the same real samples with recoveries in the range of 95-99.6% and a relative standard deviation lower than 4.0%.

  15. (Acetonitrile[bis(2-pyridylmethylamine]bis(perchloratocopper(II

    Directory of Open Access Journals (Sweden)

    Ray J. Butcher

    2008-01-01

    Full Text Available In the title compound, [Cu(ClO42(C12H13N3(C2H3N], the CuII atom is six-coordinate in a Jahn–Teller distorted octahedral geometry, with coordination by the tridentate chelating ligand, an acetonitrile molecule, and two axial perchlorate anions. The tridentate ligand bis(2-pyridylmethylamine chelates meridionally and equatorially while an acetonitrile molecule is coordinated at the fourth equatorial site. The two perchlorate anions are disordered with site occupancy factors of 0.72/0.28. The amine H is involved in intramolecular hydrogen bonding to the perchlorate O atoms and there are extensive but weak intermolecular C—H...O interactions.

  16. Bis[cis-bis(diphenylphosphinoethene]copper(I dichloridocuprate(I

    Directory of Open Access Journals (Sweden)

    Peter C. Healy

    2010-05-01

    Full Text Available The crystal structure of the title compound, [Cu(C26H22P22][CuCl2], is composed of discrete Cu(dppey2]+ cations [dppey is cis-bis(diphenylphosphinoethene] and [CuCl2]− anions. The tetrahedral Cu(P—P2 core of the [Cu(dppey2]+ cation is distorted, with Cu—P bond lengths ranging from 2.269 (1 to 2.366 (1 Å. The five-membered –Cu—P—CH=CH—P– rings adopt envelope conformations, with the Cu atom lying 0.38 and 0.65 Å out of the P—C=C—P planes. The Cu—Cl distances in the [CuCl2]− anion are 2.094 (2 and 2.096 (2 Å, with a Cl—Cu—Cl angle of 176.81 (7°.

  17. Expanding the family of heteroleptic oxidovanadium(IV) compounds with salicylaldehyde semicarbazones and polypyridyl ligands showing anti-Trypanosoma cruzi activity.

    Science.gov (United States)

    Scalese, Gonzalo; Benítez, Julio; Rostán, Santiago; Correia, Isabel; Bradford, Lara; Vieites, Marisol; Minini, Lucía; Merlino, Alicia; Coitiño, E Laura; Birriel, Estefania; Varela, Javier; Cerecetto, Hugo; González, Mercedes; Pessoa, João Costa; Gambino, Dinorah

    2015-06-01

    Searching for prospective vanadium-based drugs for the treatment of Chagas disease, a new series of heteroleptic [V(IV)O(L-2H)(NN)] compounds was developed by including the lipophilic 3,4,7,8-tetramethyl-1,10-phenanthroline (tmp) NN ligand and seven tridentate salicylaldehyde semicarbazone derivatives (L1-L7). The compounds were characterized in the solid state and in solution. EPR spectroscopy suggests that the NN ligand is bidentate bound through both nitrogen donor atoms in an axial-equatorial mode. The EPR and (51)V-NMR spectra of aerated solutions at room temperature indicate that the compounds are stable to hydrolysis and that no significant oxidation of V(IV) to V(V) takes place at least in 24h. The complexes are more active in vitro against Trypanosoma cruzi, the parasite responsible for Chagas disease, than the reference drug Nifurtimox and most of them are more active than previously reported [V(IV)O(L-2H)(NN)] complexes of other NN co-ligands. Selectivity towards the parasite was analyzed using J-774 murine macrophages as mammalian cell model. Due to both, high activity and high selectivity, L2, L4, L5 and L7 complexes could be considered new hits for further drug development. Lipophilicity probably plays a relevant role in the bioactivity of the new compounds. The [V(IV)O(L-2H)(NN)] compounds were designed aiming DNA as potential molecular target. Therefore, the novel L1-L7 tmp complexes were screened by computational modeling, comparing their DNA-binding features with those of previously reported [V(IV)O(L-2H)(NN)] compounds with different NN co-ligands. Whereas all the complexes interact well with DNA, with binding modes and strength tuned in different extents by the NN and semicarbazone co-ligands, molecular docking suggests that the observed anti-T. cruzi activity cannot be explained upon DNA intercalation as the sole mechanism of action. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. coordination polymers derived from two different bis-pyridyl-bis-am

    Indian Academy of Sciences (India)

    Self-assembly, structures and properties of three new Ni(II) coordination polymers derived from two different bis-pyridyl-bis-amide ligands and two aromatic polycarboxylates. HONGYAN LIN. ∗. , JUNJUN SUN, GUOCHENG LIU. ∗. , XIANG WANG and PANWEN CHEN. Department of Chemistry, Bohai University, Jinzhou ...

  19. coordination polymers derived from two different bis-pyridyl-bis-am

    Indian Academy of Sciences (India)

    Sci. Vol. 129, No. 1, January 2017, pp. 9–20. c Indian Academy of Sciences. DOI 10.1007/s12039-016-1213-y. REGULAR ARTICLE. Self-assembly, structures and properties of three new Ni(II) coordination polymers derived from two different bis-pyridyl-bis-amide ligands and two aromatic polycarboxylates. HONGYAN LIN.

  20. 40 CFR 721.5925 - Bis heterocyclic phenylene derivative (generic).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Bis heterocyclic phenylene derivative... Specific Chemical Substances § 721.5925 Bis heterocyclic phenylene derivative (generic). (a) Chemical... as bis heterocyclic phenylene derivative (PMN P-01-0432) is subject to reporting under this section...

  1. 40 CFR 721.1187 - Bis(imidoethylene) benzene.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Bis(imidoethylene) benzene. 721.1187... Substances § 721.1187 Bis(imidoethylene) benzene. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance bis(imidoethylene)benzene (PMN P-93-1447) is subject to reporting...

  2. Biochemical characterization of propylglyoxal bis(guanylhydrazone). Facile synthesis of monoalkylglyoxal bis(guanylhydrazones).

    Science.gov (United States)

    Elo, H; Laine, R; Alhonen-Hongisto, L; Jänne, J; Mutikainen, I; Lumme, P

    1985-01-01

    Propylglyoxal bis(guanylhydrazone) sulfate, a novel analog of the well-known antileukemic drug methylglyoxal bis(guanylhydrazone), has been prepared from 2,2-dibromopentanal, and the compound has been characterized biochemically. Although it is a powerful inhibitor of S-adenosylmethionine decarboxylase, its Ki value (0.2 microM) is considerably higher than that of ethylglyoxal bis(guanylhydrazone) (0.06 microM). The compound is only poorly taken up by tumor cells, and its accumulation is not stimulated by a prior exposure of the tumor cells to difluoromethylornithine, a compound that causes polyamine depletion. Thus, the uptake characteristics of the compound are similar to those of ethylglyoxal bis(guanylhydrazone), but in striking contrast to those of methylglyoxal and glyoxal bis(guanylhydrazones). Since the configuration of the double bonds in glyoxal, methylglyoxal and propylglyoxal bis(guanylhydrazones) has been shown to be identical, the different uptake characteristics are probably only due to differences in side chain size and/or hydrophobicity.

  3. Supramolecular chemistry of bis-porphyrins

    OpenAIRE

    Hernández Eguía, Laura P.

    2010-01-01

    (Base de datos de tesis doctorales TESEO) English versionIn this doctoral thesis two main aspects are developed. The first is the synthesis of bis-porphyrin receptors metallated with zinc, both acyclic and cyclic, and with different degrees of saturation of the carbon chain, and the second deals with the studies of complexation with ligands of different types and properties: amines and fullerenes. The first ligands are connected by metal-nitrogen coordination between the nitrogen of the liga...

  4. Comparisons Between Tridentate Bis(benzazoles-pyridine and Bis(benzazolestriazine Ligands: a Theoretical Study

    Directory of Open Access Journals (Sweden)

    Mihaiela Andoni

    2015-12-01

    Full Text Available Twelve bis(benzazole structures with potential ligand character were investigated by means of computational chemistry. Global and local reactivity descriptors within DFT (Density Functional Theory theory (Fukui functions, chemical potential, hardness, electrophilicity index have been computed at B3LYP/6-31G(d,p level of theory. NICS(0 (Nucleus Independent Chemical Shift index computations were employed for the evaluation of the local aromatic character of each heterocyclic moiety. Best results have been reported for the bis(benzimidazole derivatives. Copper and zinc complexes of the investigated tridentate ligands have been proposed.

  5. A binuclear cobalt(II) complex of an NO(3)-donor Schiff base derived from 3-carboxyl-salicylaldehyde and 2-nitro-aniline.

    Science.gov (United States)

    Yu, Zhao-Wen; Chang, Ling; Sun, Peng; He, Min-Hui

    2008-12-20

    In the crystal structure of the centrosymmetric title complex, bis-{μ-3-[(2-nitro-phen-yl)imino-meth-yl]-2-oxidobenzoato}dicobalt(II), [Co(2)(C(14)H(8)N(2)O(5))(2)], in which the ligand is 3-[(2-nitro-phen-yl)imino-meth-yl]-2-oxidobenzoate, a Schiff base synthesized from 2-nitro-aniline with 3-carboxyl-salicyl-aldehyde, the two cobalt(II) ions in the mol-ecular unit are bridged by two phenolate O atoms of the ligands. Each metal centre has a distorted square-planar geometry. In the crystal structure, mol-ecules are linked by Co⋯O inter-actions involving the nitro O atoms, forming a two-dimensional network. There are also C-H⋯O and π-π stacking inter-actions [centroid-centroid distances of 3.5004 (2), 3.6671 (2) and 3.6677 (2) Å] between adjacent benzene rings of the two-dimensional networks, leading to the formation of a three-dimensional framework.

  6. A binuclear cobalt(II) complex of an NO3-donor Schiff base derived from 3-carboxyl­salicylaldehyde and 2-nitro­aniline

    Science.gov (United States)

    Yu, Zhao-Wen; Chang, Ling; Sun, Peng; He, Min-Hui

    2009-01-01

    In the crystal structure of the centrosymmetric title complex, bis­{μ-3-[(2-nitro­phen­yl)imino­meth­yl]-2-oxidobenzoato}dicobalt(II), [Co2(C14H8N2O5)2], in which the ligand is 3-[(2-nitro­phen­yl)imino­meth­yl]-2-oxidobenzoate, a Schiff base synthesized from 2-nitro­aniline with 3-carboxyl­salicyl­aldehyde, the two cobalt(II) ions in the mol­ecular unit are bridged by two phenolate O atoms of the ligands. Each metal centre has a distorted square-planar geometry. In the crystal structure, mol­ecules are linked by Co⋯O inter­actions involving the nitro O atoms, forming a two-dimensional network. There are also C—H⋯O and π–π stacking inter­actions [centroid–centroid distances of 3.5004 (2), 3.6671 (2) and 3.6677 (2) Å] between adjacent benzene rings of the two-dimensional networks, leading to the formation of a three-dimensional framework. PMID:21581483

  7. Enthalpies of combustion of two bis(N,N-diethylthioureas)

    International Nuclear Information System (INIS)

    Ribeiro da Silva, Manuel A.V.; Santos, Luis M.N.B.F.; Schroeder, Bernd; Beyer, Lothar; Dietze, Frank

    2007-01-01

    The standard (p o =0.1MPa) molar energies of combustion in oxygen, at T=298.15K, of two crystalline bis(N,N-diethylthioureas) R(CONHCSNEt 2 ) 2 : pyridine-2,6-dicarbonyl-bis(N,N-diethylthiourea), R=pyridyl , abbreviated as (bis-py-DETU), and adipoyl-dicarbonyl-bis(N,N-diethylthiourea), R=(CH 2 ) 4 , abbreviated as (bis-ad-DETU), were measured by rotating bomb calorimetry so, the standard molar enthalpies of formation of both compounds, in their crystalline phase, were derived. Compound-Δ c U m o (cr)-Δ f H m o (cr)kJ.mol -1 kJ.mol -1 Pyridine-2,6-dicarbonyl-bis(N,N -diethylthiourea) [bis-py-DETU]11027.1+/-5.2425.2+/-5.6Adipoyl-dicarbonyl-bis (N,N-diethylthiourea) [bis-ad-DETU]11124.6+/-5.7644.4+/-6.1Furthermore, the energetics of the title compounds were studied by means of density functional theory calculations at the B3LYP/ 6-311G(dp) level of theory.

  8. Poly[bis[μ-1,4-bis(imidazol-1-ylmethylbenzene]dichloridocadmium(II

    Directory of Open Access Journals (Sweden)

    Xinliang Hu

    2008-07-01

    Full Text Available The title compound, [CdCl2(C14H14N42]n, has a slightly distorted octahedral coordination geometry, formed by four N atoms from 1,4-bis(imidazol-1-ylmethylbenzene ligands and two Cl atoms, giving a two-dimensional network. The Cd atom lies on a centre of inversion.

  9. Dimethylammonium bis(3-oxidonaphthalene-2-carboxylatoborate hemihydrate

    Directory of Open Access Journals (Sweden)

    Mustafa Tombul

    2008-01-01

    Full Text Available The title compound, C2H8N+·C22H12BO6−·0.5H2O, was synthesized under atmospheric conditions in the presence of dimethylformamide acting as a template. The structure is composed of [NH2(CH32]+ cations, bis(3-oxidonaphthalene-2-carboxylatoborate anions and water molecules. The water molecule lies on a twofold rotation axis. The stabilization of the crystal structure comes from electrostatic interactions and is assisted by intermolecular O—H...O and N—H...O hydrogen bonds between the layers.

  10. Accelerated optical holographic recording using bis-DNO

    DEFF Research Database (Denmark)

    Rasmussen, Palle H.; Ramanujam, P.S.; Hvilsted, Søren

    1999-01-01

    The design, synthesis and optical holographic recording properties of bis-DNO are reported. Bis-DNO is composed of two identical azobenzene oligoornithine segments (DNO) connected via a dipeptide linker. The two segments were assembled in a parallel fashion at the two amino groups of the dipeptide...

  11. Synthesis & Characterization of New bis-Symmetrical Adipoyl ...

    African Journals Online (AJOL)

    Full Title: Synthesis and Characterization of New bis-Symmetrical Adipoyl, Terepthaloyl, Chiral Diimido-di-L-alanine Diesters and Chiral Phthaloyl-L-alanine Ester of Tripropoxy p-tert-Butyl Calix[4]arene and Study of Their Hosting Ability for Alanine and Na+. Bis-symmetrical tripropoxy p-tert-butyl calix[4]arene esters were ...

  12. Studies on Bis(Para Anisidine Acetylacetonato) Nickel (II) Complex ...

    African Journals Online (AJOL)

    Studies on Bis(Para Anisidine Acetylacetonato) Nickel (II) Complex. HN Aliyu, UL Bilyamin. Abstract. Schiff base was prepared from the reaction of para anisidine and acetylacetone. Bis(para anisidineacetylacetonato)nickel(II) complex was synthesized by the reaction of the prepared para anisidineacetylacetone ligand and ...

  13. A bis-calixarene from olefin metathesis

    Directory of Open Access Journals (Sweden)

    Shimelis T. Hailu

    2012-06-01

    Full Text Available A ring-closing olefin metathesis reaction of tetrakis(allyloxycalix[4]arene gave the bis calixarene, (15E,40E,60E-65,74-bis(prop-2-en-1-yloxy-13,18,38,43,58,63-hexaoxadodecacyclo[28.26.8.720,36.111,45.151,55.05,57.07,12.019,24.026,64.032,37.044,49.168,72]tetraheptaconta-1,3,5(57,7,9,11,15,19(24,20,22,26,28,30(64,32,34,36,40,44(49,45,47,51,53,55(65,60,68,70,72(74-heptacosaene, C74H68O8. It is a cage formed from two calix[4]arene units joined by butenyl groups at three of the O atoms on the narrow rim. The fourth O atom on each calixarene unit is joined with an allyl group. Each of the calix[4]arene units has a flattened cone conformation in which the allyloxy-substituted aryl group and the opposite aryl group are close together and almost parallel [dihedral angle between planes = 1.09 (11°], and the other two aryl groups are splayed outward [dihedral angle between planes = 79.53 (11°]. No guest molecule (e.g. solvent was observed within the cage. The alkene C atoms of one of the links between the calixarene moieties are disordered over two orientations with occupancies of 0.533 (9 and 0.467 (9.

  14. Bis(μ-bis{[4-(2-pyridylpyrimidin-2-yl]sulfanyl}methanedisilver(I bis(perchlorate

    Directory of Open Access Journals (Sweden)

    Hai-Bin Zhu

    2010-12-01

    Full Text Available In the macrocyclic centrosymmetric dinuclear complex, [Ag2(C19H14N6S22](ClO42, the AgI atom, bis{[4-(2-pyridylpyrimidin-2-yl]sulfanyl}methane (2-bppt ligand and perchlorate anion each lie on a twofold rotation axis. The 2-bppt ligand chelates two four-coordinated AgI atoms through its two bipyridine-like arms. The O atoms of the perchlorate anion are disordered each over two positions of equal occupancy. Adjacent complex molecules are linked by π–π interactions between the pyridine and pyrimidine rings [centroid–centroid distance = 3.663 (8 Å].

  15. O uso de aparelhos de micro-ondas domésticos em aulas experimentais de química orgânica: nitração de salicilaldeído The use of domestic microwave oven in experimental classes of organic chemistry: salicylaldehyde nitration

    Directory of Open Access Journals (Sweden)

    Eurídes Francisco Teixeira

    2010-01-01

    Full Text Available The use of microwave in chemistry has known benefits over conventional heating methods, e.g. reduced reaction times, chemical yield improvement and the possibility if reducing or eliminating the use of organic solvents. We describe herein a procedure for the nitration of salicylaldehyde in water using a domestic microwave oven, which can be used as an experiment in the undergraduate chemistry laboratory. The experiment involves safe and rapid preparation and identification of the position isomers by thin layer chromatography and 1H NMR, or by their melting points.

  16. Crystal structure of bis[bis(4-azaniumylphenyl sulfone] tetranitrate monohydrate

    Directory of Open Access Journals (Sweden)

    Amani Hind Benahsene

    2017-11-01

    Full Text Available In the title compound, the hydrated tetra(nitrate salt of dapsone (4,4′-diaminodiphenylsulfone, 2C12H14N2O2S2+·4NO3−·H2O {alternative name: bis[bis(4,4′-diazaniumylphenyl sulfone] tetranitrate monohydrate}, the cations are conformationally similar, with comparable dihedral angles between the two benzene rings in each of 70.03 (18 and 69.69 (19°. In the crystal, mixed cation–anion–water molecule layers lying parallel to the (001 plane are formed through N—H...O, O—H...O and C—H...O hydrogen-bonding interactions and these layers are further extended into an overall three-dimensional supramolecular network structure. Inter-ring π–π interactions are also present [minimum ring centroid separation = 3.693 (3 Å].

  17. Atomic layer deposition of molybdenum oxide using bis(tert-butylimido)bis(dimethylamido) molybdenum

    International Nuclear Information System (INIS)

    Bertuch, Adam; Sundaram, Ganesh; Saly, Mark; Moser, Daniel; Kanjolia, Ravi

    2014-01-01

    Molybdenum trioxide films have been deposited using thermal atomic layer deposition techniques with bis(tert-butylimido)bis(dimethylamido)molybdenum. Films were deposited at temperatures from 100 to 300 °C using ozone as the oxidant for the process. The Mo precursor was evaluated for thermal stability and volatility using thermogravimetric analysis and static vapor pressure measurements. Film properties were evaluated with ellipsometry, x-ray photoelectron spectroscopy, secondary ion mass spectroscopy, and secondary electron microscopy. The growth rate per cycle was determined to extend from 0.3 to 2.4 Å/cycle with <4% nonuniformity (1-sigma) with-in-wafer across a 150 mm wafer for the investigated temperature range

  18. Bis{N,N-bis[(diphenylphosphanylmethyl]aniline-κ2P,P′}copper(I tetrafluoridoborate

    Directory of Open Access Journals (Sweden)

    Qing-Ling Ni

    2011-01-01

    Full Text Available In the cation of the title compound, [Cu(C32H29NP22]BF4, the CuI atom is four-coordinated in a distorted tetrahedral geometry by four P atoms from two N,N-bis[(diphenylphosphanylmethyl]aniline ligands. In the crystal, the cations are linked by C—H...π interactions, forming chains along the a axis. Intramolecular C—H...N and intermolecular C—H...F hydrogen bonds are also observed.

  19. Synthesis of Acridine-based DNA Bis-intercalating Agents

    Directory of Open Access Journals (Sweden)

    P. Mack

    2001-02-01

    Full Text Available Methods for the synthesis of N1, N8-bis(9-acridinyl-N4-(4-hydroxybenzyl-spermidine and N1, N7-(hydroxybenzyl-bis-(3-aminopropylamine were investigated. Thus monocyanoethylation of 4-methoxybenzylamine followed by treatment with 4-chlorobutyronitrile gave the dinitrile N-(2-cyanoethyl-N-(3-cyanopropyl-4-methoxybenzylamine. Subsequent in situ reduction with lithium aluminium hydride gave the corresponding diamine. Biscyanoethylation of 4-methoxybenzylamine with 2 mole of acrylonitrile followed by reduction yielded the diamine N, N-bis-(3-aminopropyl-4-methoxybenzylamine. Both diamines reacted smoothly with 9-methoxyacridine to give the bis-(9-acridinyl compounds 11 and 15 but with 4,5-dimethyl-9-methoxyacridine, the bis compound 16 was produced in only low yields. Demethylation of the dinitriles by a variety of approaches all failed to give the corresponding hydroxybenzyl derivatives. These studies yielded useful methylated tyrosine derivatives which could also be iodinated. This study has been useful for elucidating chemical methods needed for the synthesis of the desired tyrosine-based bis acridine compound and for alerting us to the need to synthesise a more labile protected tyrosine intermediate which will be easily deprotected to afford the desired tyrosine-based bis acridine compound.

  20. Spectral Properties and Variability of BIS objects

    Science.gov (United States)

    Gaudenzi, S.; Nesci, R.; Rossi, C.; Sclavi, S.; Gigoyan, K. S.; Mickaelian, A. M.

    2017-10-01

    Through the analysis and interpretation of newly obtained and of literature data we have clarified the nature of poorly investigated IRAS point sources classified as late type stars, belonging to the Byurakan IRAS Stars catalog. From medium resolution spectroscopy of 95 stars we have strongly revised 47 spectral types and newly classified 31 sources. Nine stars are of G or K types, four are N carbon stars in the Asymptotic Giant Branch, the others being M-type stars. From literature and new photometric observations we have studied their variability behaviour. For the regular variables we determined distances, absolute magnitudes and mass loss rates. For the other stars we estimated the distances, ranging between 1.3 and 10 kpc with a median of 2.8 kpc from the galactic plane, indicating that BIS stars mostly belong to the halo population.

  1. 78 FR 8586 - PEPSICO, Inc., Business & Information Solutions (BIS) Division Including On-Site Leased Workers...

    Science.gov (United States)

    2013-02-06

    ... Procurestaff, Cognizant, Infosys, Wipro, and TCS; Plano, TX; PEPSICO, Inc., Business & Information Solutions... Solutions (BIS) Division, Plano, Texas (PepsiCo-BIS-Plano). Workers of PepsiCo-BIS are engaged in activities... former workers of PepsiCo-BIS-Plano. The Department has received information that PepsiCo, Inc., Business...

  2. Mono- and bis-thiazolium salts have potent antimalarial activity.

    Science.gov (United States)

    Hamzé, Abdallah; Rubi, Eric; Arnal, Pascal; Boisbrun, Michel; Carcel, Carole; Salom-Roig, Xavier; Maynadier, Marjorie; Wein, Sharon; Vial, Henri; Calas, Michèle

    2005-05-19

    Three new series comprising 24 novel cationic choline analogues and consisting of mono- or bis (N or C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium salts showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium salts 12 and 13 exhibited IC(50) values of 2.25 nM and 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good in vivo activity (ED(50)

  3. A comparative study of the metal binding behavior of alanine based bis-thiourea isomers

    OpenAIRE

    Fakhar, Imran; Yamin, Bohari M.; Hasbullah, Siti Aishah

    2017-01-01

    Two new symmetrical bis-thiourea, 2,2?-[{(terephthaloylbis(azanediyl)bis(carbonothioyl) bis(azanediyl)}dipropanoic acid] (1A) and 3,3?-[{(terephthaloylbis(azanediyl)bis (carbonothioyl)bis(azanediyl)} dipropanoic acid] (1B) were synthesized by the reaction of terephthaloyl chloride with ?- and ?-alanine in good yields. Their binding properties were investigated with various metal cations using UV?Vis titration experiments. Both isomers exhibited effective binding with Ag+, Cu2+, Hg2+, Pb2+, Fe...

  4. Isolation and Characterization of Bis (2 – Methoxyethyl) Phthalate ...

    African Journals Online (AJOL)

    Isolation and Characterization of Bis (2 – Methoxyethyl) Phthalate and Hexashydro-1 3 – Dimethyl – 4 – Phenyl – 1h – Azepine 4 – Carboxylic Acid from the Root of Cissampelos Owariensis (P. Beauv)

  5. High pressure synthesis of BiS2

    DEFF Research Database (Denmark)

    Søndergaard-Pedersen, Simone; Nielsen, Morten Bormann; Bremholm, Martin

    crystal structures and electrical properties.1,2 Up until now, the most sulfur rich phase in the Bi-S phase diagram was Bi2S3.3 For BiS2 the Bi atoms have anisotropic charge distribution and more complex structures are expected when comparing the layered structures of transition metal dichalcogenides....... The possibilities of using high pressure synthesis to discover new phases in the Bi-S binary system were investigated as early as the 1960’s.4 The research led to discovery of a compound with BiS2 stoichiometry, but no structure solution of BiS2 was reported. A reason behind making this new phase is to study...... the physical properties since the related compound Bi2S3 is known to be a thermoelectric material.5 In this research the BiS2 compound was synthesized by a high pressure and high temperature method using a multi-anvil large volume press and the structure was solved by single crystal diffraction. The structure...

  6. A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest

    Directory of Open Access Journals (Sweden)

    Ahmad Sami Shawali

    2016-11-01

    Full Text Available This review covers a summary of the literature data published on the chemistry of bis-hydrazonoyl halides over the last four decades. The biological activities of some of the bis-heterocyclic compounds obtained from these bis-hydrazonoyl halides are also reviewed and discussed.

  7. Bis[cis-bis(diphenylphosphino)ethene]copper(I) dichloridocuprate(I)

    OpenAIRE

    Peter C. Healy; John C. McMurtrie; Jocelyne Bouzaid

    2010-01-01

    The crystal structure of the title compound, [Cu(C26H22P2)2][CuCl2], is composed of discrete Cu(dppey)2]+ cations [dppey is cis-bis(diphenylphosphino)ethene] and [CuCl2]− anions. The tetrahedral Cu(P—P)2 core of the [Cu(dppey)2]+ cation is distorted, with Cu—P bond lengths ranging from 2.269 (1) to 2.366 (1) Å. The five-membered –Cu—P—CH=CH—P– rings adopt envelope conformatio...

  8. Synergistic extraction of Eu(III) with N-phosphorylated bis-ureas and chlorinated cobalt bis(dicarbollide) ion

    Czech Academy of Sciences Publication Activity Database

    Selucký, P.; Bubeníková, M.; Rais, J.; Grüner, Bohumír; Brusko, V.V.

    2013-01-01

    Roč. 101, č. 1 (2013), s. 27-31 ISSN 0033-8230 R&D Projects: GA ČR GA104/09/0668 Institutional support: RVO:61388980 Keywords : liquid-liquid extraction * lanthanides * actinides * N-phosphorylated bis-ureas * chlorinated cobalt bis(dicarbollide) ion * high level liquid waste Subject RIV: CA - Inorganic Chemistry Impact factor: 1.411, year: 2013

  9. Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).

    Science.gov (United States)

    Alhonen-Hongisto, L; Fagerström, R; Laine, R; Elo, H; Jänne, J

    1984-01-01

    Three bis(guanylhydrazones) (those of methylglyoxal, glyoxal and ethylglyoxal) were compared for their affinity for the putative polyamine carrier and for their cellular retention in L1210 mouse leukaemia cells. All the bis(guanylhydrazones) inhibited equally effectively the uptake of spermidine by the tumour cells, indicating that the compounds had roughly equal affinity for the polyamine carrier. The fact that methylglyoxal bis(guanylhydrazone) and glyoxal bis(guanylhydrazone) were much more effectively concentrated in the animal cells than was ethylglyoxal bis(guanylhydrazone) was obviously attributable to the finding that the efflux rate of ethylglyoxal bis(guanylhydrazone) greatly exceeded that of the other bis(guanylhydrazones). The rate of efflux of the drugs was slowed down if the tumour cells were treated with 2-difluoromethylornithine before exposure to the bis(guanylhydrazones). These results suggest that intracellular binding of the bis(guanylhydrazones) determines their cellular accumulation. PMID:6431972

  10. Preparation of 177Lu-DTPA-BIS-BIOTIN and biodistribution evaluation in normal mice

    International Nuclear Information System (INIS)

    Deng Xinrong; Luo Zhifu; Du Jin

    2010-01-01

    The labeling method for 177 Lu-DTPA-BIS-BIOTIN was established, and the biodistribution of 177 Lu-DTPA-BIS-BIOTIN in normal mice was carried out as well. Under the optimal experimental condition (DTPA-BIS-BIOTIN 25 μg, pH=4.5 reacting at 80 degree C for 20 min), the labeling yield of 177 Lu-DTPA-BIS-BIOTIN is more than 99.0%. 177 Lu-DTPA-BIS-BIOTIN shows pretty good in vitro stability. The biodistribution of 177 Lu-DTPA-BIS-BIOTIN in normal mice shows a rapid blood clearance. The uptake of 177 Lu-DTPA-BIS-BIOTIN is mainly accumulated in liver, spleen and kidney. 177 Lu-DTPA-BIS-BIOTIN is excreted by kidney. The results provide the basis for further study on 177 Lu-DTPA-BIS-BIOTIN used in pretargeted radioimage and radiotherapy of cancer. (authors)

  11. Estructura molecular y cristalina del bis (bis(dietilamino glioximato níquel (II

    Directory of Open Access Journals (Sweden)

    Luis Alejandro Nuvan

    2009-07-01

    Full Text Available Ni(CioH2lN4022- monoclínico, grupo espacial P2i/a, a = 15.760 (2, b = 11.793 (3, c = 7.297 (1 A°, j3 = 99.10 (1°, V = 1339.0 (7 A°3, Z = 2 , De = 1.28 Mg M " \\ M = 765 M " ' . La estructura fue resuelta por el método del átomo pesado y afinada por mínimos cuadrados, utilizando la matriz completa, hasta obtener una concordancia R = 0.068 para todas las reflexiones observadas. El átomo de níquel está localizado en un centro de inversión y presenta una coordinación cuadrado planar. El complejo Bis (Bis (Dietilamino Glioximato Níquel (II es casi planar y el desplazamiento de los grupos etil con respecto al plano es producido por efectos estéricos. Las moléculas planares se apilan a lo largo de c, las normales a los planos forman con este eje un ángulo de 41.53 . Existen interacciones axiales entre el níquel y los grupos amino de las moléculas adyacentes de la columna.

  12. Ethylglyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in L1210 leukemia cells.

    Science.gov (United States)

    Seppänen, P; Ruohola, H; Jänne, J

    1984-04-16

    Ethylglyoxal bis(guanylhydrazone), a close derivative of the known anti-cancer drug methylglyoxal bis(guanylhydrazone), is also a powerful inhibitor of S-adenosylmethionine decarboxylase (EC 4.1.1.50), the enzyme needed for the synthesis of spermidine and spermine. There were, however, marked differences between the ethyl and methyl derivatives of glyoxal bis(guanylhydrazone) when tested in cultured L1210 cells. The cellular accumulation of ethylglyoxal bis(guanylhydrazone) represented only a fraction (20-25%) of that of the methyl derivative. Moreover, polyamine depletion, which is known to strikingly stimulate the uptake of methylglyoxal bis(guanylhydrazone), decreased, if anything, the uptake of ethylglyoxal bis(guanylhydrazone) by L1210 cells. The compound produced spermidine and spermine depletion fully comparable to that achieved with methylglyoxal bis(guanylhydrazone) at micromolar concentrations. Ethylglyoxal bis(guanylhydrazone) was growth-inhibitory to L1210 cells and produced an additive antiproliferative action when used together with 2-difluoromethylornithine. Ethylglyoxal bis(guanylhydrazone) was distinctly less effective than methylglyoxal bis(guanylhydrazone) in releasing bound polyamines from isolated cell organelles in vitro. Ethylglyoxal bis(guanylhydrazone) was also devoid of the early and profound mitochondrial toxicity typical to methylglyoxal bis(guanylhydrazone). These findings may indicate that this compound is a more specific inhibitor of polyamine biosynthesis with less intracellular polyamine 'receptor-site' activity than methylglyoxal bis(guanylhydrazone).

  13. Apoptosis and survivability of human dental pulp cells under exposure to Bis-GMA

    Directory of Open Access Journals (Sweden)

    Junya Yano

    2011-06-01

    Full Text Available OBJECTIVE: In the present study, we examined whether 2, 2-bis [4-(2-hydroxy-3-methacryloxypropoxy phenyl] propane (Bis-GMA has effects on LSC2 cells, human dental pulp cell line. MATERIAL AND METHODS: The viability, cell cycle, and morphology of LSC2 cells were analyzed after exposure to several different concentrations of Bis-GMA. The recovery of viability of Bis-GMA exposed cells was also analyzed in the condition without Bis-GMA. Further, penetration of Bis-GMA to dentin disc was examined using isocratic high-performance liquid chromatography. RESULTS: There was a concentration-dependent decrease in cell proliferation and an increase in cell number in the sub-G1 population after exposure to Bis-GMA. Furthermore, the cells showed typical characteristics of apoptotic cells after the exposure to high concentration of Bis-GMA. In contrast, cells exposed to lower concentrations of Bis-GMA recovered their viability after being cultured without Bis-GMA. We also found that Bis-GMA is capable of penetrating 1-mm-thick dentin discs, though the penetrated concentration was lower than that showing cytotoxicity. CONCLUSION: These results suggest that Bis-GMA has cytotoxic effects, though dental pulp exposed to lower concentrations is able to recover their viability when Bis-GMA is removed.

  14. LA REINCIDENCIA VULNERA EL “NON BIS IN IDEM”

    OpenAIRE

    Roger Cabrera Paredes

    2011-01-01

    El presente artículo explica como la “Reincidencia vulnera el  Non bis in ídem”; empezamos con la “Introducción” que comprende los antecedentes, la formulación del problema y la justificación de esta investigación. Continuamos con las “Bases Teóricas”, la misma que comprende el sentido de los principios penales, el principio “Non bis in Idem”, la Reincidencia y la Problemática de la Reincidencia como vulneración del Principio Non bis in ídem. En la “Metodología”, encontramos la tipología y me...

  15. cadmium(II) coordination polymers based on semi-rigid/flexible bis

    Indian Academy of Sciences (India)

    flexible bis-pyridyl-bis-amide ligands and. 5-aminoisophthalate: Syntheses, structures and properties. HONGYAN LINa, HUIZHE LUb, MAO LEa, JIAN LUANa, XIULI WANGa,∗ and. GUOCHENG LIUa. aDepartment of Chemistry, Bohai University, ...

  16. Rahumeelse läbisõidu õigus Venemaa Föderatsiooni Soome lahe vetest / Alexander Lott

    Index Scriptorium Estoniae

    Lott, Alexander, 1987-

    2017-01-01

    Venemaa Föderatsiooni õigusraamistikust ja praktikast välisriikide laevade rahumeelse läbisõidu õiguse kohta oma Soome lahe territoriaalmeres ja olukorrast, et Venemaa ei tunnusta rahumeelse läbisõidu õigust selles merealas

  17. Le principe non bis in idem et le droit communautaire

    OpenAIRE

    Hedabou, Aziz

    2018-01-01

    Le principe non bis in idem est une garantie fondamentale qui interdit que les mêmes faits soit poursuivi et puni deux fois. Il est reconnu par tous les droits internes et “appartient aux droit universel des nations”. Dès lors, sa lettre et son esprit ne sont plus cantonnés au droit interne et ont tendance à s’internationaliser. En droit communautaire, l’étude du principe non bis in idem peut être envisagée sous trois angles différents. D’abord en droit pénal international unilatéral où chaqu...

  18. Biodistribution of bis(short-chain-amino)-ortho-dicarbaborane hydrochloride

    International Nuclear Information System (INIS)

    Yinghuai, Zhu; Bin, Pek Han; Zhun, Zhu Yi

    2006-01-01

    Bis(aminomethyl)-ortho-dicarbaborane hydrochloride and their nido-derivates, which may potentially be used as boron neutron capture therapy agents, have been synthesized from corresponding bis(short-chain-phthalimido)acetylenes in 81% yield. The pharmacokinetics of the type compounds is studied in healthy mice. Blood, liver, lung and spleen samples are collected at 8, 16, 30 and 48 hours after intra-peritoneal administration of the compound in healthy mice. In the study, the compound has been well absorbed and peak much earlier. (author)

  19. Glyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in tumour cells.

    OpenAIRE

    Seppänen, P; Fagerström, R; Alhonen-Hongisto, L; Elo, H; Lumme, P; Jänne, J

    1984-01-01

    Glyoxal bis(guanylhydrazone), the parent compound of methylglyoxal bis(guanylhydrazone), was synthesized and tested for its ability to inhibit the biosynthesis of polyamines. It was found to be a powerful competitive inhibitor of adenosylmethionine decarboxylase (EC 4.1.1.50), yet the lack of the methyl group at the glyoxal portion increased the apparent Ki value for the enzyme by about 30-fold in comparison with methylglyoxal bis(guanylhydrazone). Glyoxal bis(guanylhydrazone) inhibited diami...

  20. Behavioral inhibition system (BIS), Behavioral activation system (BAS) and schizophrenia : Relationship with psychopathology and physiology

    NARCIS (Netherlands)

    Scholten, Marion R. M.; van Honk, Jack; Aleman, Andre; Kahn, Rene S.

    2006-01-01

    Objective: The Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS) have been conceptualized as two neural motivational systems that regulate sensitivity to punishment (BIS) and reward (BAS). Imbalance in BIS and BAS levels has been reported to be related to various forms of

  1. 40 CFR 721.5860 - Methylphenol, bis(sub-sti-tuted)alkyl.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Methylphenol, bis(sub-sti-tuted)alkyl... Substances § 721.5860 Methylphenol, bis(sub-sti-tuted)alkyl. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as methylphenol, bis-(sub-sti-tut...

  2. Gray's Reinforcement Sensitivity Model and Child Psychopathology: Laboratory and Questionnaire Assessment of the BAS and BIS

    Science.gov (United States)

    Colder, Craig R.; O'Connor, Roisin M.

    2004-01-01

    The Behavioral Approach System (BAS) and Behavioral Inhibition System (BIS) are widely studied components of Gray's sensitivity to reinforcement model. There is growing interest in integrating the BAS and BIS into models of risk for psychopathology, however, few measures assess BAS and BIS functioning in children. We adapted a questionnaire…

  3. 40 CFR 721.10096 - Benzene, 1,4-bis (methoxymethyl)-.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Benzene, 1,4-bis (methoxymethyl)-. 721... Substances § 721.10096 Benzene, 1,4-bis (methoxymethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 1,4-bis (methoxymethyl)- (PMN P-03...

  4. Iron(III) Chloride mediated reduction of Bis(1-isoquinolylcarbonyl ...

    Indian Academy of Sciences (India)

    atoms of the ligand and two chloride ions, imparting a rare distorted trigonal bipyramidal N3Cl2 coordination environment. Keywords. Reduction; Ferric chloride; Isoquinoline; Bis(carbonyl)amide. 1. Introduction. Iron(III) chloride has been known to catalyze or assist several kinds of organic reactions.1–3 This includes.

  5. KINETICS OF SUBSTITUTION OF CIS-BIS(MALONATO ...

    African Journals Online (AJOL)

    Preferred Customer

    substrate exists predominantly as the diaquospecies and amino acids (glycine, DL-alanine and DL-phenylalanine) as the zwitterion at ... KEY WORDS: Substitution, cis-bis(malonato)diaquochromate(III), Amino acids ... chromium(III) ion results in an impairment of intravenous glucose tolerance and diabetics like symptoms in ...

  6. 2,6-Bis(9-ethyl-9H-carbazolylmethylenecyclohexanone

    Directory of Open Access Journals (Sweden)

    Abdullah M. Asiri

    2009-10-01

    Full Text Available The title compound, 2,6-bis(ethyl-9-ethyl-9H-carbazolylmethylenecyclohexanone has been synthesized by condensation of 9-ethylcarbazole-3-aldehyde and cyclohexanone in ethanol in the presence of pyridine. The structure of this new compound was confirmed by elemental analysis, IR, 1H NMR, 13C NMR and EI-MS spectral analysis.

  7. Non bis in idem : De ontwikkeling van een beginsel

    NARCIS (Netherlands)

    van Hattum, W.F.

    2012-01-01

    Non bis in idem. The development of a principle The double jeopardy rule forbids a second prosecution for the same offence. The rule is applicable after irrevocable judgments: condemnations as well as acquittals. If a conviction is subsequently found to be wrong, it is annulled. But what if an

  8. LA REINCIDENCIA VULNERA EL “NON BIS IN IDEM”

    Directory of Open Access Journals (Sweden)

    Roger Cabrera Paredes

    2011-06-01

    Full Text Available El presente artículo explica como la “Reincidencia vulnera el  Non bis in ídem”; empezamos con la “Introducción” que comprende los antecedentes, la formulación del problema y la justificación de esta investigación. Continuamos con las “Bases Teóricas”, la misma que comprende el sentido de los principios penales, el principio “Non bis in Idem”, la Reincidencia y la Problemática de la Reincidencia como vulneración del Principio Non bis in ídem. En la “Metodología”, encontramos la tipología y metodología de la investigación. En los “Resultados”,  están los análisis y la decisión final de las entrevistas y encuestas a Docentes y abogados especializados en el tema y al personal de Juzgados, Fiscalías y abogados, respectivamente, del Distrito Judicial de Iquitos de la Provincia de Maynas, región Loreto. En la “Discusión”, explicamos que la Reincidencia debe desaparecer porque va en contra del principio Non bis in ídem, colocando en las “Conclusiones” nuestra posición.

  9. LA REINCIDENCIA VULNERA EL “NON BIS IN IDEM”

    Directory of Open Access Journals (Sweden)

    Roger Cabrera-Paredes

    2011-07-01

    Full Text Available El presente artículo explica como la “Reincidencia vulnera el  Non bis in ídem”; empezamos con la “Introducción” que comprende los antecedentes, la formulación del problema y la justificación de esta investigación. Continuamos con las “Bases Teóricas”, la misma que comprende el sentido de los principios penales, el principio “Non bis in Idem”, la Reincidencia y la Problemática de la Reincidencia como vulneración del Principio Non bis in ídem. En la “Metodología”, encontramos la tipología y metodología de la investigación. En los “Resultados”,  están los análisis y la decisión final de las entrevistas y encuestas a Docentes y abogados especializados en el tema y al personal de Juzgados, Fiscalías y abogados, respectivamente, del Distrito Judicial de Iquitos de la Provincia de Maynas, región Loreto. En la “Discusión”, explicamos que la Reincidencia debe desaparecer porque va en contra del principio Non bis in ídem, colocando en las “Conclusiones” nuestra posición.

  10. Activation of peroxyl and molecular oxygen using bis-benzimidazole ...

    Indian Academy of Sciences (India)

    New tetradentate bis-benzimidazole ligands have been synthesized and utilized to prepare copper (II) complexes. Some of these copper (II) complexes have been characterized structurally. The copper (II) in these complexes is found to possess varying geometries. A distorted octahedral geometry is found with a highly ...

  11. Activation of peroxyl and molecular oxygen using bis-benzimidazole ...

    Indian Academy of Sciences (India)

    ... corresponding quinones, in oxygen-saturated solvents. Yields of 84% have been observed with 34-fold catalyst turnover, with di--butylcatechol. The activity of these copper (II) - bis-benzmidazolediamide compounds is reminiscent of the functioning of copper centres in galactose oxidase, tyrosinase and catechol oxidase ...

  12. Electronic states of 1,4-bis(phenylethynyl)benzene

    DEFF Research Database (Denmark)

    Nguyen, Duy Duc; Jones, Nykola; Hoffmann, Søren Vrønning

    2012-01-01

    The electronic transitions of 1,4-bis(phenylethynyl)benzene (BPEB) were investigated by UV synchrotron radiation linear dichroism (SRLD) spectroscopy in the range 25,000 – 58,000 cm–1 (400 – 170 nm) on molecular samples aligned in stretched polyethylene. The investigation was supported by variable...

  13. Polymerization behavior of butyl bis(hydroxymethyl)phosphine oxide ...

    Indian Academy of Sciences (India)

    lenovo

    Polymerization behavior of butyl bis(hydroxymethyl)phosphine oxide: Phosphorus containing polyethers for. Li‒ion conductivities. Heeralal Vignesh Babu, Billakanti Srinivas and Krishnamurthi Muralidharan*. School of Chemistry, University of Hyderabad, Hyderabad - 500046, India. Table of Contents. TGA plots of SPE2.

  14. GRINDING TECHNIQUE FOR THE TANDEM SYNTHESIS OF BIS ...

    African Journals Online (AJOL)

    , Iran. (Received March 4 ... [BDBDMIm]Br-CANunder grinding as a green and novel method (Scheme 1). RESULTS AND ... In order to make this reaction simple and green, herein, we used ionic liquid [BDBDMIm]Br to the synthesis of bis.

  15. Grinding technique for the tandem synthesis of bis coumarinyl ...

    African Journals Online (AJOL)

    Br) is easily used as an efficient and recyclable ionic liquid for the synthesis of bis coumarinyl methanes in the presence of a catalytic amount of ceric ammonium nitrate (CAN) under grinding. All reactions are performed in the absence of solvent ...

  16. Preparation, Characterisation and In vivo Evaluation of Bis ...

    African Journals Online (AJOL)

    Purpose: To fabricate biodegradable nanoparticle formulation of bis-demethoxy curcumin analogue (BDMCA), a novel curcumin analogue, and evaluate its in vitro and in vivo characteristics. Methods: Nanoparticle formulations were fabricated by a double emulsion solvent evaporation technique using polycaprolactone as ...

  17. Liquid Crystalline Derivatives of Bis(tricarbollide)Fe(II)

    Czech Academy of Sciences Publication Activity Database

    Januszko, A.; Kaszynski, P.; Grüner, Bohumír

    2007-01-01

    Roč. 46, č. 15 (2007), s. 6078-6082 ISSN 0020-1669 Institutional research plan: CEZ:AV0Z40320502 Keywords : Bis(tricarbollide)Fe(II) Subject RIV: CA - Inorganic Chemistry Impact factor: 4.123, year: 2007

  18. Isolation and Characterization of Stigmasterol and Bis-(5, 7-diacetyl ...

    African Journals Online (AJOL)

    Nigerian Journal of Basic and Applied Sciences ... from the hexane fraction and a catechin glycoside, Bis-(5,7-diacetyl-catechin-4'-α- rhamnopyranoside) was isolated from the ethylacetate soluble fraction using a combination of silica gel column, gel filtration (sephadex LH-20) and preparative thin layer chromatography.

  19. Thermodynamic investigation of the MOCVD of copper films from bis ...

    Indian Academy of Sciences (India)

    Equilibrium concentrations of various condensed and gaseous phases have been thermodynamically calculated, using the free energy minimization criterion, for the metalorganic chemical vapour deposition (MOCVD) of copper films using bis(2,2,6,6-tetramethyl-3,5-heptadionato)copper(II) as the precursor material.

  20. Bis(pyrrole-benzimidazole) conjugates as novel colorimetric sensor ...

    Indian Academy of Sciences (India)

    Sanjeev Pran Mahanta

    Bis(pyrrole-benzimidazole) conjugates as novel colorimetric sensor for anions. SANJEEV PRAN MAHANTAa,b,∗ and PRADEEPTA KUMAR PANDAb,∗. aDepartment of Chemical Sciences, Tezpur University, Napaam, Assam 784 028, India. bSchool of Chemistry, University of Hyderabad, Hyderabad, Telengana 500 046, ...

  1. Bis(pyrrole-benzimidazole) conjugates as novel colorimetric sensor ...

    Indian Academy of Sciences (India)

    Sanjeev Pran Mahanta

    Abstract. Novel bis(pyrrole-benzimidazole) (PYBI) conjugates were investigated as colorimetric anion recognition motif by employing multiple donor sites. In this regard, PYBI derivatives where pyrrole unit is connected to the C2 position of benzimidazole via its α-position were synthesized and their anion recognition.

  2. Glucose selective bis-boronic acid click-fluor.

    Science.gov (United States)

    Zhai, Wenlei; Male, Louise; Fossey, John S

    2017-02-14

    Four novel bis-boronic acid compounds were synthesised via copper catalysed azide-alkyne cycloaddition (CuAAC) reactions. Glucose selectivity was observed for a particular structural motif. Moreover, a new glucose selective fluorescent sensor was designed and synthesised as a result.

  3. Bis[cis-bis­(diphenyl­phosphino)ethene]copper(I) dichloridocuprate(I)

    Science.gov (United States)

    Healy, Peter C.; McMurtrie, John C.; Bouzaid, Jocelyne

    2010-01-01

    The crystal structure of the title compound, [Cu(C26H22P2)2][CuCl2], is composed of discrete Cu(dppey)2]+ cations [dppey is cis-bis­(diphenyl­phosphino)ethene] and [CuCl2]− anions. The tetra­hedral Cu(P—P)2 core of the [Cu(dppey)2]+ cation is distorted, with Cu—P bond lengths ranging from 2.269 (1) to 2.366 (1) Å. The five-membered –Cu—P—CH=CH—P– rings adopt envelope conformations, with the Cu atom lying 0.38 and 0.65 Å out of the P—C=C—P planes. The Cu—Cl distances in the [CuCl2]− anion are 2.094 (2) and 2.096 (2) Å, with a Cl—Cu—Cl angle of 176.81 (7)°. PMID:21578996

  4. Bis[cis-bis-(diphenyl-phosphino)ethene]copper(I) dichloridocuprate(I).

    Science.gov (United States)

    Healy, Peter C; McMurtrie, John C; Bouzaid, Jocelyne

    2010-04-10

    The crystal structure of the title compound, [Cu(C(26)H(22)P(2))(2)][CuCl(2)], is composed of discrete Cu(dppey)(2)](+) cations [dppey is cis-bis-(diphenyl-phosphino)ethene] and [CuCl(2)](-) anions. The tetra-hedral Cu(P-P)(2) core of the [Cu(dppey)(2)](+) cation is distorted, with Cu-P bond lengths ranging from 2.269 (1) to 2.366 (1) Å. The five-membered -Cu-P-CH=CH-P- rings adopt envelope conformations, with the Cu atom lying 0.38 and 0.65 Å out of the P-C=C-P planes. The Cu-Cl distances in the [CuCl(2)](-) anion are 2.094 (2) and 2.096 (2) Å, with a Cl-Cu-Cl angle of 176.81 (7)°.

  5. 2,6-Bis(oxazolinyl)phenylnickel(II) Bromide and 2,6-Bis(ketimine)phenylnickel(II) Bromide: Synthesis, Structural Features, and Redox Properties

    NARCIS (Netherlands)

    Stol, M.; Snelders, D.J.M.|info:eu-repo/dai/nl/304836257; Godbole, M.D.; Havenith, R.W.A.|info:eu-repo/dai/nl/205279546; Haddleton, D.M.; Clarkson, G.; Lutz, M.|info:eu-repo/dai/nl/304828971; Spek, A.L.|info:eu-repo/dai/nl/156517566; van Klink, G.P.M.|info:eu-repo/dai/nl/170637964; van Koten, G.|info:eu-repo/dai/nl/073839191

    2007-01-01

    2,6-Bis(oxazolinyl)phenylnickel bromide complexes [NiBr(R,R'-Phebox)] (2) were synthesized via two synthetic routes (A and B). In route A, selective bis-ortho lithiation of [R,R'-PheboxBr], followed by a transmetalation reaction with [NiBr2(PEt3)2], yielded not only complexes 2 with an

  6. Dust Measurement of Two Organophosphorus Flame Retardants, Resorcinol Bis(diphenylphosphate) (RBDPP) and Bisphenol A Bis(diphenylphosphate) (BPA-BDPP), Used as Alternatives for BDE-209

    NARCIS (Netherlands)

    Brandsma, S.H.; Sellström, U.; de Wit, C.A.; de Boer, J.; Leonards, P.E.G.

    2013-01-01

    Resorcinol bis(diphenylphosphate) (RBDPP) and bisphenol A bis(diphenylphosphate) (BPA-BDPP) are two halogen-free organophosphorus flame retardant (PFRs) that are used as an alternative for the decabromodiphenyl ether (Deca-BDE) technical mixture in TV/flatscreen housing and other electronic consumer

  7. {μ(2)-1,4-Bis[2-(4-pyrid-yl)ethen-yl]benzene-κN:N'}bis-[bis-(acetyl-acetonato-κO,O')copper(II)].

    Science.gov (United States)

    Jian, Fang-Fang; Wang, Jing; Zhang, Jing

    2009-11-21

    The asymmetric unit of the title compound, [Cu(2)(C(5)H(7)O(2))(4)(C(20)H(16)N(2))], contains half of a centrosymmetric dinuclear mol-ecule. In the mol-ecule, each Cu center is coordinated by four O atoms from two acetyl-acetonate ligands and one N atom from the bridging linear 1,4-bis-[2-(4-pyrid-yl)ethen-yl]benzene ligand in a square-pyramidal geometry. In the crystal structure, weak inter-molecular C-H⋯O hydrogen bonds link mol-ecules into sheets parallel to the bc plane.

  8. Novel bis(indolyl)hydrazide-hydrazones as potent cytotoxic agents.

    Science.gov (United States)

    Kumar, Dalip; Maruthi Kumar, N; Ghosh, Soumitra; Shah, Kavita

    2012-01-01

    A series of bis(indolyl) hydrazide-hydrazones 5a-n were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-carboxaldehyde 2 with indole-3-carbohydrazide 4 in presence of catalytic amount of acetic acid afforded 5a-n in good yields. Among the synthesized bis(indolyl)hydrazide-hydrazones, the compound 5b with N-(p-chlorobenzyl) and bromo substituents was found to be the most potent against multiple cancer cell lines (IC(50)=1.0 μM, MDA-MB-231). The compound 5k exhibited selective cytotoxicity against breast cancer cell line MCF7 (IC(50)=3.1 μM). Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Method for synthesizing metal bis(borano) hypophosphite complexes

    Science.gov (United States)

    Cordaro, Joseph G.

    2013-06-18

    The present invention describes the synthesis of a family of metal bis(borano) hypophosphite complexes. One procedure described in detail is the syntheses of complexes beginning from phosphorus trichloride and sodium borohydride. Temperature, solvent, concentration, and atmosphere are all critical to ensure product formation. In the case of sodium bis(borano) hypophosphite, hydrogen gas was evolved upon heating at temperatures above 150.degree. C. Included in this family of materials are the salts of the alkali metals Li, Na and K, and those of the alkaline earth metals Mg and Ca. Hydrogen storage materials are possible. In particular the lithium salt, Li[PH.sub.2(BH.sub.3).sub.2], theoretically would contain nearly 12 wt % hydrogen. Analytical data for product characterization and thermal properties are given.

  10. New adjacent Bis-tetrahydrofuran Annonaceous acetogenins from Annona muricata.

    Science.gov (United States)

    Chang, Fang-Rong; Liaw, Chih-Chuang; Lin, Chih-Yuan; Chou, Chi-Jung; Chiu, Hui-Fen; Wu, Yang-Chang

    2003-03-01

    Bioactivity-guided fractionation led to the isolation of two new Annonaceous acetogenins, annocatacin A ( 1). and annocatacin B ( 2). from the seeds and the leaves, respectively, of Annona muricata. Compounds 1 and 2 are the first examples where the adjacent bis-tetrahydrofuran ring system is located at C-15. The new structures were elucidated and characterized by spectral and chemical methods. Both Annonaceous acetogenins 1 and 2 showed significant in vitro cytotoxicity toward the human hepatoma cell lines, Hep G2 and 2,2,15, and were compared with the known adjacent bis-tetrahydrofuran acetogenins, neoannonin ( 3). desacetyluvaricin ( 4). bullatacin ( 5). asimicin ( 6). annoglaucin ( 7). squamocin ( 8). and rollimusin ( 9).

  11. Convenient synthesis of bis(alkoxy)rhenium(VII) complexes

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Z.; Al-Ajlouni, A.M.; Espenson, J.H. [Iowa State Univ., Ames, IA (United States)

    1996-02-28

    The study of high-oxidation-state organorhenium compounds has been a field of continuing activity, thanks to the success of methylrhenium trioxide (CH{sub 3}ReO{sub 3} or MTO) in catalytic processes. This catalyst is effective in oxidations, olefin metathesis, the olefination of aldehydes, and the preparation of other compounds with three-membered rings. The syntheses of some rhenium compounds derived form MTO have been reported. Epoxide formation is a key reaction, and it bears directly on these findings reported here. Re(VII) complexes containing a chelated bis(diolate) ligand can be synthesized by refluxing MTO with 2,3-dimethyl-2,3-diol. Here, the authors report a more convenient method for this preparation. A different series of related compounds consists of chelated bis(diolates) of the Cp*Re-oxo series, Cp*ReO-(diolate).

  12. Relative Clinical Success of Bis-Acryl Composite Provisional Crowns.

    Science.gov (United States)

    Kozmacs, Carla; Baumann, Vanessa; Bunz, Oskar; Piwowarczyk, Andree

    2018-01-01

    The high demands on the clinical performance of a single-tooth provisional restoration necessitate that said performance be examined. The authors evaluated 24 teeth evaluated. Two test groups received bis-acrylic composite for provisional crowns (n = 12) and a single-unit, self-supporting, malleable, light-curing composite crown (n = 12). Final crowns (n = 24) served as paired controls. Evaluation of clinical success was measured using previously selected subcategories of FDI criteria. Statistical analysis was performed using McNemar's Test (α = 0.05). The null hypothesis of no improvement of the definitive crown relative to the provisionals was rejected at the 5% significance level (McNemar's P value provisional crowns, 75% received a clinically insufficient valuation, while only 8% of the definitive crowns did. The authors concluded that, independent of the manufacturing process, a bis-acrylic composite provisional crown cannot serve as a replacement for a conventionally manufactured definitive crown.

  13. (R,R-Disynephrine ether bis(hydrogen sulfate

    Directory of Open Access Journals (Sweden)

    William Arbuckle

    2009-08-01

    Full Text Available The asymmetric unit of the title compound [systematic name: (R,R-2,4-bis(4-hydroxyphenyl-N,N′-dimethyl-3-oxapentane-1,5-diammonium bis(hydrogen sulfate], C18H26N2O32+·2HSO4−, contains one half-cation and one hydrogen sulfate anion. The cation has crystallographically imposed twofold symmetry with the rotation axis passing through the central ether O atom. Hydrogen bonds between the hydroxy group and amine H atoms of the cation to two hydrogen sulfate anions link the three ions in a ring motif. A three-dimensional network is accomplished by additional O—H...O hydrogen bonds between the anions and by N—H...O hydrogen bonds between the cations. Disorder with equally occupied sites affects the H-atom position in the anion.

  14. Bis{4-[(3-phenylallylideneamino]cyclohexyl}methane trichloromethane solvate

    Directory of Open Access Journals (Sweden)

    Wolfgang Imhof

    2008-12-01

    Full Text Available The title compound, C31H38N2, was prepared from bis(4-aminocyclohexylmethane and two equivalents of cinnamaldehyde. The cyclohexyl groups each show a chair conformation and the α,β-unsaturated imine side chains are all-trans configured. Two molecules of the title compound as well as two trichloromethane solvent molecules are present in the asymmetric unit. The solvent molecules interact with the diimines via weak C—H...N hydrogen bonds.

  15. The Cephalostatins 22. Synthesis of Bis-steroidal Pyrazine Pyrones

    OpenAIRE

    Pettit, George R.; Moser, Bryan R.; Mendonça, Ricardo F.; Knight, John C.; Hogan, Fiona

    2012-01-01

    Cephalostatin 1 (1), a remarkably strong cancer cell growth inhibitory trisdecacyclic, bis-steroidal pyrazine isolated from the marine tube worm Cephalodiscus gilchristi, continues to be an important target for practical total syntheses and a model for the discovery of less complex structural modifications with promising antineoplastic activity. In the present study, the cephalostatin E and F rings were greatly simplified by replacement at C-17 with an α-pyrone (in 12), typical of the steroid...

  16. UNIVERSAL JURISDICTION AND THE PRINCIPLE OF NE BIS IN IDEM

    Directory of Open Access Journals (Sweden)

    MIHAELA AGHENITEI

    2011-04-01

    Full Text Available Universal jurisdiction was defined as “the assertion of jurisdiction to prescribe in the absence of any other accepted jurisdictional nexus at the time of the relevant conduct.” Professor Randall, in his seminal work on universal jurisdiction, opined that the theory of universality “provides every state with jurisdiction over a limitedcategory of offenses generally recognized as of universal concern, regardless of the situs of the offence and the nationalities of the offender and the offended. ”Universal jurisdiction is considered a tool for promoting greater justice, but the rights of the accused must be protected. One of the most important guarantees is the principle of ne bis in idem, which protected persons against multiple prosecutions for the same crime. The main legal consequence of the application of ne bis in idem in most systems is the prohibition and inadmissibility of subsequent prosecutions on the same facts blocking effect.The national ne bis in idem principle is established asan individual right in international human rights legal instruments, such as the International Covenant on Civil and Political Rights of 19 December 1966, in Article 14(7. At the regional level, Article 8(4 of the American Convention of Human Rights (1969 and Article 4 (I of the Seventh Protocol of the European Convention of Human Rights merit mention. In Europe, the ne bis in idem principle is enshrined in Article 54 of the Convention implementing the Schengen Agreement of 14 June 1985, which prohibits the initiation of a second trial for the same offence when final judgment has been imposed upon a person by a court of a contracting party.

  17. Regioselective synthesis of chiral dimethyl-bis(ethylenedithiotetrathiafulvalene sulfones

    Directory of Open Access Journals (Sweden)

    Flavia Pop

    2015-07-01

    Full Text Available Enantiopure (R,R and (S,S-dimethyl-bis(ethylenedithiotetrathiafulvalene monosulfones have been synthesized by the aerial oxidation of the chiral dithiolates generated from the propionitrile-protected precursors. Both enantiomers crystallize in the orthorhombic chiral space group P212121. They show a boat-type conformation of the TTF moiety, a rather rigid dithiin sulfone ring and the methyl groups in a bisequatorial conformation. Cyclic voltammetry measurements indicate fully reversible oxidation in radical cation and dication species.

  18. Maternal BIS Sensitivity, Overprotective Parenting, and Children’s Internalizing Behaviors

    Science.gov (United States)

    Kiel, Elizabeth J.; Maack, Danielle J.

    2012-01-01

    Although sensitivity to the Behavioral Inhibition System within Gray’s (1970) reinforcement sensitivity theory relates to individuals’ own depressive and anxious symptomatology, less is known about how parental BIS sensitivity relates to early indicators of internalizing problems in young children. Moreover, the extent to which this parental characteristic relates to parenting behavior, and children’s internalizing problems above and beyond parenting, remains unknown. The current study assessed maternal BIS sensitivity, overprotective parenting, and toddlers’ internalizing behaviors in a sample of 91 mothers while controlling for mothers’ own internalizing symptomatology. Heightened BIS sensitivity related to both overprotective parenting and internalizing behaviors. Overprotective parenting partially mediated the relation between BIS sensitivity and children’s internalizing behaviors, although BIS sensitivity maintained a marginal relation to internalizing behaviors. Maternal BIS sensitivity and toddler internalizing behaviors may represent a shared disposition towards inhibition that is somewhat accounted for by overprotective parenting. PMID:22904590

  19. Glyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in tumour cells.

    Science.gov (United States)

    Seppänen, P; Fagerström, R; Alhonen-Hongisto, L; Elo, H; Lumme, P; Jänne, J

    1984-07-15

    Glyoxal bis(guanylhydrazone), the parent compound of methylglyoxal bis(guanylhydrazone), was synthesized and tested for its ability to inhibit the biosynthesis of polyamines. It was found to be a powerful competitive inhibitor of adenosylmethionine decarboxylase (EC 4.1.1.50), yet the lack of the methyl group at the glyoxal portion increased the apparent Ki value for the enzyme by about 30-fold in comparison with methylglyoxal bis(guanylhydrazone). Glyoxal bis(guanylhydrazone) inhibited diamine oxidase (EC 1.4.3.6) activity as effectively as did methylglyoxal bis(guanylhydrazone). The cellular accumulation curves of glyoxal bis(guanylhydrazone) in L1210 cells were practically superimposable with those of methylglyoxal bis(guanylhydrazone), and the uptake of both compounds was distinctly stimulated by a prior treatment with 2-difluoromethylornithine. The drug decreased the concentration of spermidine in a dose-dependent manner and, in contrast with methylglyoxal bis(guanylhydrazone), without a concomitant accumulation of putrescine. The fact that putrescine concentrations were decreased in cells exposed to glyoxal bis(guanylhydrazone) was, at least in part, attributable to an inhibition of ornithine decarboxylase (EC 4.1.1.17) activity in cells treated with the compound. Under these experimental conditions equivalent concentrations of methylglyoxal bis(guanylhydrazone) [1,1'-[(methylethanediylidine)dinitrilo]diguanidine] elicited large increases in the enzyme activity. When combined with difluoromethylornithine, glyoxal bis(guanylhydrazone) potentiated the growth-inhibitory effect of that drug. Taking into consideration the proven anti-leukaemic activity of glyoxal bis(guanylhydrazone), its effectiveness to inhibit spermidine biosynthesis (without raising the concentration of putrescine) as well as its suitability for combined use with inhibitors of ornithine decarboxylase, this drug is apparently worthy of further testing in tumour-bearing animals, especially in

  20. Characterizing carver and white’s BIS/BAS subscales using the five factor model of personality

    OpenAIRE

    Segarra, Pilar; Poy Gil, Roser; López Penadés, Raúl; Moltó Brotons, Javier

    2014-01-01

    This study examined BIS/BAS scales (Carver & White, 1994) assessment of Gray’s revised Reinforcement Sensitivity Theory in the light of the Five-Factor Model of personality—assessed via NEO-PI-R domains and facets—in a mixed-gender sample of 329 undergraduates. Exploratory factor analysis confirmed a 5-factor solution structure of the BIS/BAS scales, with BIS-scale divided into BIS-Anxiety and BIS-Fear factors, besides the original three BAS factors. BIS-Anxiety was found to represent Gray’s ...

  1. Ne bis in idem põhimõte Eesti karistusõiguses : [bakalaureusetöö] / Natalja Mogiljova ; Tartu Ülikool, õigusteaduskond ; juhendaja: Elina Elkind

    Index Scriptorium Estoniae

    Mogiljova, Natalja

    2009-01-01

    Ne bis in idem põhimõtte olemusest ja ajaloolisest arengust, horisontaalsest riigisisesest ne bis in idem-ist, rahvusvahelistest konventsioonidest, EIÕK praktikast, Riigikohtu praktikast, ne bis in idem Ameerika Ühendriikide õiguskorras

  2. Sakurai reaction of 3,3-bis(silyl) silyl enol ethers with acetals involving selective desilylation of the geminal bis(silane). Concise synthesis of nematocidal oxylipid.

    Science.gov (United States)

    Li, Linjie; Ye, Xincui; Wu, Ya; Gao, Lu; Song, Zhenlei; Yin, Zhiping; Xu, Yongjin

    2013-03-01

    3,3-Bis(silyl) silyl enol ethers have been shown to exhibit predominantly Sakurai reactivity, rather than Mukaiyama aldol reactivity, in their Lewis acid promoted reactions with acetals. Starting from a geminal bis(silyl) moiety consisting of two different silyl groups, such as SiMe(3) and SiMe(2)Ph, the SiMe(3) is selectively eliminated to give monoprotected E- vinylsilyl diols with good to excellent syn-diastereoselectivity. This reaction also underpinned a synthesis of the nematocidal oxylipid from Notheia anomala, demonstrating the attractive bifunctionality of geminal bis(silanes).

  3. Teratogenic effects of bis-diamine on early embryonic rat heart: an in vitro study.

    Science.gov (United States)

    Nishijima, S; Nakagawa, M; Fujino, H; Hanato, T; Okamoto, N; Shimada, M

    2000-08-01

    Bis-diamine induces cardiac defects, including conotruncal anomalies in rat embryos when the agent is administered to the mother. To evaluate the teratogenic effects and mechanism of bis-diamine, we performed morphological and immunohistochemical analyses of early rat embryos cultured in medium containing bis-diamine. The embryos were removed from mother rats on gestational day 10.5 and cultured in medium containing 1 mg of bis-diamine for 6 hr. The embryos were then cultured in medium only for another 6, 12, 18, and 42 hr, corresponding to embryonic day (ED) 11.0, 11.25, 11.5, and 12.5, respectively. Some embryos from the same mothers were used as controls and were cultured in medium only for the corresponding periods to the embryos exposed to bis-diamine. Some mother rats were given a single oral dose of 200 mg of bis-diamine on gestational day 10.5. Embryos from these pregnant rats were removed 6 hr after the oral administration of bis-diamine, and were also cultured in medium only for 6, 12, 18, and 42 hr. No cardiac abnormalities were detected in the controls at any stage of development. Thirty-three of 51 (65%) embryos exposed to bis-diamine and 15 of 20 (75%) embryos removed from bis-diamine-administered mothers showed abnormal cardiac development, including dilated ventricle, elongation of outflow tract, and pericardial defect on ED 11.5. Four of six (67%) embryos exposed to bis-diamine, and five of seven (71%) removed from bis-diamine-administered mothers also presented almost the same cardiac abnormalities on ED 12.5. No cardiac abnormalities were detected in bis-diamine-treated embryos before ED 11.5. In addition, the expression of neural cell adhesion molecule (N-CAM) was examined using immunohistochemical methods. Fewer N-CAM immunoreactive cells were detected in the third and fourth aortic arches in the bis-diamine-treated embryos than in controls on ED 11.5. However, more N-CAM immunoreactive cells were detected in the bis-diamine-treated embryos

  4. Synechocystis PCC 6803 overexpressing RuBisCO grow faster with increased photosynthesis

    Directory of Open Access Journals (Sweden)

    Feiyan Liang

    2017-06-01

    Full Text Available The ribulose-1,5-bisphosphate (RuBP oxygenation reaction catalyzed by Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO is competing with carboxylation, being negative for both energy and carbon balances in photoautotrophic organisms. This makes RuBisCO one of the bottlenecks for oxygenic photosynthesis and carbon fixation. In this study, RuBisCO was overexpressed in the unicellular cyanobacterium Synechocystis PCC 6803. Relative RuBisCO levels in the engineered strains FL50 and FL52 increased 2.1 times and 1.4 times, respectively, and both strains showed increased growth, photosynthesis and in vitro RuBisCO activity. The oxygen evolution rate increased by 54% and 42% on per chlorophyll basis, while the in vitro RuBisCO activity increased by 52% and 8.6%, respectively. The overexpressed RuBisCO were tagged with a FLAG tag, in strain FL50 on the N terminus of the large subunit while in strain FL52 on the C terminus of the small subunit. The presence of a FLAG tag enhanced transcription of the genes encoding RuBisCO, and, with high possibility, also enhanced the initiation of translation or stability of the enzyme. However, when using a streptavidin-binding tag II (strep-tag II, we did not observe a similar effect. Tagged RuBisCO offers an opportunity for further studying RuBisCO expression and stability. Increased levels of RuBisCO can further improve photosynthesis and growth in the cyanobacterium Synechocystis PCC 6803 under certain growth conditions.

  5. Bis[2,6-bis(trimethylsilylaminopyridine-κN1]{[6-bis(trimethylsilylaminopyridin-2-yl-κN1](trimethylsilylazanido-κN}lithium

    Directory of Open Access Journals (Sweden)

    Justin A. Rave

    2016-03-01

    Full Text Available The title complex, [Li(C11H22N3Si2(C11H23N3Si22], contains a single lithium cation coordinated to three ligands. This is the first reported example of the ligand 2,6-bis(trimethylsilylaminopyridine supporting a monometallic complex. One ligand is mono-anionic and forms a four-membered chelate ring with the lithium cation via the pyridine and silylamido N atoms. The other two ligands are neutral and bind via the pyridine nitrogen. The lithium cation is coordinated in a tetrahedral environment. No intra- or intermolecular hydrogen bonding is observed in the crystal structure, likely indicating that weak electrostatic interactions are the dominant feature of the crystal packing.

  6. Characterization of Bis-Acryl Composite Resins for Provisional Restorations.

    Science.gov (United States)

    Schwantz, Júlia K; Oliveira-Ogliari, Aline; Meereis, Carine T; Leal, Fernanda B; Ogliari, Fabrício A; Moraes, Rafael R

    2017-01-01

    This study investigated the in vitro performance of the commercial bis-acryl composite resins Systemp C&B II (SYS, Ivoclar Vivadent), Protemp 4 (PT4, 3M ESPE), Structur 2C (ST2, Voco) and ProviPlast (PVP, Biodinamica). Characterization involved optical (color stability, translucency parameter, fluorescence), surface (roughness, morphology and elemental composition), physical-chemical (viscosity, polymerization kinetics) and mechanical analyses (Poisson ratio, biaxial flexural strength, flexural modulus). Most tests were carried out after 24 h, but optical and mechanical analyses were carried out after storage in water at 37 °C for 1, 15, and 30 days. Data were statistically analyzed (a=0.05). Most results were material dependent. SYS and PT4 showed stability in color and translucency over time. All materials had similar or higher fluorescence than human enamel. SC2 and PVP showed rougher surfaces than the other bis-acryl composites. Smaller filler particles were observed on the surface of PT4 and PVP compared with the coarser particles from ST2 and SYS. Viscosity readings indicated a thixotropic behavior for all tested materials. SYS had the lowest and PT4 the highest degree of C=C conversion after 10 min. In the polymerization kinetics, PT4 had the highest maximum polymerization rate and reached earlier the transition between polymerization autoacceleration and autodeceleration. PT4 and SYS had significantly higher flexural strength and modulus than ST2 and PVP for most storage times. Results for Poisson ratio varied between materials. Longer storage periods were generally associated with higher frequency of catastrophic failures in the flexural tests. In conclusion, the performance of bis-acryl composite resins varied largely among materials.

  7. Synthesis and Antitumor Evaluation of Novel Bis-Triaziquone Derivatives

    Directory of Open Access Journals (Sweden)

    Yuh-Ling Lin

    2009-06-01

    Full Text Available Aziridine-containing compounds have been of interest as anticancer agents since late 1970s. The design, synthesis and study of triaziquone (TZQ analogues with the aim of obtaining compounds with enhanced efficacy and reduced toxicity are an ongoing research effort in our group. A series of bis-type TZQ derivatives has been prepared and their cytotoxic activities were investigated. The cytotoxicity of these bis-type TZQ derivatives were tested on three cancer lines, including breast cancer (BC-M1, oral cancer (OEC-M1, larynx epidermal cancer (Hep2 and one normal skin fibroblast (SF. Most of these synthetic derivatives displayed significant cytotoxic activities against human carcinoma cell lines, but weak activities against SF. Among tested analogues the bis-type TZQ derivative 1a showed lethal effects on larynx epidermal carcinoma cells (Hep2, with an LC50 value of 2.02 mM, and also weak cytotoxic activity against SF cells with an LC50 value over 10 mM for 24 hr treatment. Comparing the viability of normal fibroblast cells treated with compound 1a and TZQ, the LC50 value of the latter was 2.52 mM, indicating more toxicity than compound 1a. This significantly decreased cytotoxicity of compound 1a towards normal SF cells, while still maintaining the anticancer activity towards Hep2 cells is an interesting feature. Among the seven compounds synthesized, compound 1c has similar toxicity effects on the three cancer cell lines and SF normal cells as the TZQ monomer.

  8. Synthesis and characterization of nickel(II), cobalt(II), copper(II), manganese(II), zinc(II), zirconium(IV), dioxouranium(VI) and dioxomolybdenum(VI) complexes of a new Schiff base derived from salicylaldehyde and 5-methylpyrazole-3-carbohydrazide

    International Nuclear Information System (INIS)

    Syamal, A.; Maurya, M.R.

    1986-01-01

    Synthesis of a new Schiff base derived from salicylaldehyde and 5-methylpyrazole-3-carbohydrazide, and its coordination compounds with nickel(II), cobalt(II), copper(II), manganese(II), zinc(II), zirconium(IV), dioxouranium(VI) and dioxomolybdenum(VI) are described. The ligand and the complexes have been characterized on the basis of analytical, conductance, molecular weight, i.r., electronic and n.m.r. spectra and magnetic susceptibility measurements. The stoichiometries of the complexes are represented as NiL . 3H 2 O, CoL . 2H 2 O, CuL, MnL . 2H 2 O, ZnL . H 2 O, Zr(OH) 2 (LH) 2 , Zr(OH) 2 L . 2MeOH, UO 2 L . MeOH and MoO 2 L . MeOH (where LH 2 =Schiff base). The copper(II) complex shows a subnormal magnetic moment due to antiferromagnetic exchange interaction while the nickel(II), cobalt(II) and manganese(II) complexes show normal magnetic moments at room temperature. The i.r. and n.m.r. spectral studies show that the Schiff base behaves as a dibasic and tridentate ligand coordinating through the deprotonated phenolic oxygen, enolic oxygen and azomethine nitrogen. (orig.)

  9. Unconventional Superconductivity in the BiS_{2}-Based Layered Superconductor NdO_{0.71}F_{0.29}BiS_{2}.

    Science.gov (United States)

    Ota, Yuichi; Okazaki, Kozo; Yamamoto, Haruyoshi Q; Yamamoto, Takashi; Watanabe, Shuntaro; Chen, Chuangtian; Nagao, Masanori; Watauchi, Satoshi; Tanaka, Isao; Takano, Yoshihiko; Shin, Shik

    2017-04-21

    We investigate the superconducting-gap anisotropy in one of the recently discovered BiS_{2}-based superconductors, NdO_{0.71}F_{0.29}BiS_{2} (T_{c}∼5  K), using laser-based angle-resolved photoemission spectroscopy. Whereas the previously discovered high-T_{c} superconductors such as copper oxides and iron-based superconductors, which are believed to have unconventional superconducting mechanisms, have 3d electrons in their conduction bands, the conduction band of BiS_{2}-based superconductors mainly consists of Bi 6p electrons, and, hence, the conventional superconducting mechanism might be expected. Contrary to this expectation, we observe a strongly anisotropic superconducting gap. This result strongly suggests that the pairing mechanism for NdO_{0.71}F_{0.29}BiS_{2} is an unconventional one and we attribute the observed anisotropy to competitive or cooperative multiple paring interactions.

  10. The IR spectra and hydrogen bonding of toluene-2,6-bis(methyl) and 4,4'-diphenylmethane-bis(methyl) carbamates

    Science.gov (United States)

    Furer, V. L.

    2000-03-01

    The IR spectroscopy has been used to study models of polyurethanes containing different hard segments. The spectra of toluene-2,6-bis(methyl) and 4,4'-diphenylmethane-bis(methyl) carbamates at different temperatures were studied. The absorption curves of the free and associated carbamate molecules were compared with experimental IR spectra. The characteristic features of toluene-2,6-bis(methyl) carbamate and methyl- N-methyl carbamate clusters were revealed. The IR spectra for the two most stable toluene-2,6-bis(methyl) carbamate conformations were compared. The origin of the multiplet structure of bands in the experimental IR spectra of polyurethanes was discussed. The results obtained can be used for the analysis of the chemical and physical transformations in urethanes and polyurethanes.

  11. Facile Synthesis of 1,6-Bis(2-furyl-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl-2,5-diazahexane: a New Dinucleating Ligand

    Directory of Open Access Journals (Sweden)

    Chang-Rang Liu

    2001-11-01

    Full Text Available A convenient three-step preparation of the dinucleating ligand, 1,6-bis(2-furyl-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl-2,5-diazahexane (3 starting from 2,6-bis(hydroxymethyl-4-methylphenol (4 is reported. Compound 4 was partially oxidized with preactivated manganese dioxide to form compound 5, which was converted to 2-hydroxy-3-chloromethyl-5-ethylbenzaldehyde (6 with conc.HCl/EtOH. Compound 6 in turn reacted with N,N’-bis (2-furyl-1,2-diaminoethane (7 in the presence of K2CO3 in ethanol to give the title compound 3. No protecting groups were required in the whole process and the conditions were mild.

  12. Ne bis in idem põhimõte Euroopa Liidu õiguses / Uno Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Uno, 1952-

    2009-01-01

    Ne bis in idem põhimõtte ehk teistkordse kohtumõistmise ja karistamise keelu territoriaalsest kohaldamisest. Schengeni rakenduskonventsiooni artiklis 54 sisalduva ne bis in idem põhimõtte tõlgendustest. Mõistetest "sama tegu" ja "lõplik kohtuotsus"

  13. 40 CFR 721.4520 - Isopropylidene, bis(1,1-dimethylpropyl) derivative.

    Science.gov (United States)

    2010-07-01

    ...) derivative. 721.4520 Section 721.4520 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Specific Chemical Substances § 721.4520 Isopropylidene, bis(1,1-dimethylpropyl) derivative. (a) Chemical... isopropylidene, bis(1,1-dimethylpropyl) derivative (PMN P-85-648) is subject to reporting under this section for...

  14. 40 CFR 721.10143 - Amines, bis (C11-14-branched and linear alkyl).

    Science.gov (United States)

    2010-07-01

    ... linear alkyl). 721.10143 Section 721.10143 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Specific Chemical Substances § 721.10143 Amines, bis (C11-14-branched and linear alkyl). (a) Chemical..., bis (C11-14-branched and linear alkyl) (PMN P-06-733; CAS No. 900169-60-0) is subject to reporting...

  15. BiS: the formation and development of a left-wing library society in ...

    African Journals Online (AJOL)

    BiS was noted for its promotion of egalitarianism. It advanced alternative, Left wing approaches that recognised social responsibility. One of its concerns was the fate of libraries in apartheid South Africa. The overall history of BiS reflects a high level of personal commitment which prompts a concluding query as to whether ...

  16. SYNTHESIS AND STRUCTURAL ANALYSES OF BIS(2-OXO-2,3 ...

    African Journals Online (AJOL)

    SYNTHESIS AND STRUCTURAL ANALYSES OF BIS(2-OXO-2,3-. DIHYDROPYRIMIDIN-1-IUM) TETRACHLORO ZINCATE (II). [H2pymo][ZnCl4] AND BIS(PYRIMIDIN-2-OLATE) ZINC(II). [Zn(PYMO)2]. Mukhtar A. Kurawa. Department of Pure and Industrial Chemistry, Bayero University Kano. P. M. B. 3011 Kano Nigeria.

  17. 40 CFR 721.982 - Calcium, bis(2,4-pentanedionato-O,O′).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Calcium, bis(2,4-pentanedionato-O,Oâ²). 721.982 Section 721.982 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.982 Calcium, bis(2,4...

  18. Gray's BIS/BAS dimensions in non-comorbid, non-medicated social anxiety disorder.

    NARCIS (Netherlands)

    Morgan, B.E.; Honk, J. van; Hermans, E.J.; Scholten, M.R.; Stein, D.J.; Kahn, R.S.

    2009-01-01

    Gray's behavioural inhibition and behavioural activation (BIS/BAS) neural systems model has led to research on approach and withdrawal as the two most fundamental dimensions of affective behaviour, and their role in psychopathology. Although Gray proposed the BIS as the neurological basis of

  19. Comparison of non-electrophoresis grade with electrophoresis grade BIS in NIPAM polymer gel preparation

    Science.gov (United States)

    Khodadadi, Roghayeh; Khajeali, Azim; Farajollahi, Ali Reza; Hajalioghli, Parisa; Raeisi, Noorallah

    2015-01-01

    Introduction:The main objective of this study was to investigate the possibility of replacing electrophoresis cross-linker with non-electrophoresis N, N′-methylenebisacrylamide (BIS) in N-isopropyl acrylamide (NIPAM) polymer gel and its possible effect on dose response. Methods: NIPAM polymer gel was prepared from non-electrophoresis grade BIS and the relaxation rate (R2) was measured by MR imaging after exposing the gel to gamma radiation from Co-60 source. To compare the response of this gel with the one that contains electrophoresis grade BIS, two sets of NIPAM gel were prepared using electrophoresis and non-electrophoresis BIS and irradiated to different gamma doses. Results: It was found that the dose–response of NIPAM gel made from the non-electrophoresis grade BIS is coincident with that of electrophoresis grade BIS. Conclusion:Taken all, it can be concluded that the non-electrophoresis grade BIS not only is a suitable alternative for the electrophoresis grade BIS but also reduces the cost of gel due to its lower price. PMID:26457250

  20. Uptake of 153Sm-DTPA-bis-biotin and 99mTc-DTPA-bis-biotin in rat as-30D-hepatoma cells

    International Nuclear Information System (INIS)

    Correa-Gonzalez, Luis; Arteaga de Murphy, Consuelo; Ferro-Flores, Guillermina; Pedraza-Lopez, Martha; Murphy-Stack, Eduardo; Mino-Leon, Dolores; Perez-Villasenor, Graciela; Diaz-Torres, Yaneth; Munoz-Olvera, Rodrigo

    2003-01-01

    Labeled biotin has been used mainly for pretargeted therapy, an approach for increasing the amount of radioactivity delivered to a cancer cell. The aim of this investigation was to prepare 153 Sm-DTPA-bis-biotin and 99m Tc-DTPA-bis-biotin in order to study their in vitro and in vivo uptake in rat AS-30D hepatoma cells found in ascites and in implanted tumor. DTPA-bis-biotin (pH 8) was 153 Sm labeled with 153 SmCl 3 and 99m Tc-DTPA-bis-biotin was prepared via SnCl 2 reduction. Radiochemical purity was >98% in both cases. AS-30D hepatoma cells were obtained from ascites of a rat with hepatoma and were propagated in the peritoneum cavity of normal rats. In vitro ascites cell 153 Sm-DTPA-bis-biotin uptake was compared with 153 SmCl 3 cell uptake. The ratio cell 153 Sm-DTPA-bis-biotin/ 153 SmCl 3 was 39.6 and when avidin was added it increased to 50. The ratio 99m Tc-DTPA-bis-biotin/TcO 4 Na was 8.7. Concentration of 153 Sm-DTPA-bis-biotin in tumor 2, 3 and 24 h after administration, was 5, 15 and 3 times higher than in normal muscle (T/nT). Biodistribution in a 0.083-24 h time period showed that 153 Sm-DTPA-bis-biotin was taken up only by ascites tumor cells and hepatoma cells. Two and 3 h ratio ascites/liver (As/Lv) was 6.4 and 6.0. For 99m Tc-DTPA-bis-biotin 2 and 3 h T/nT was 15.7 and 4.7 and 2 h As/Lv was 1.4. In conclusion, both radiopharmaceuticals show high uptake in rat AS-30D hepatoma cells in ascites and in implanted tumor. Since lung, thyroid, kidney, liver or pancreas carcinomas are ascites producing cancers 153 Sm-DTPA-bis-biotin would be an adequate therapeutic radiopharmaceutical for these patients whose life quality would be enhanced with control of ascites, and a reduction of the primary tumor and its metastases

  1. catena-Poly[[copper(II-bis[μ-bis(pyridin-3-ylmethanone-κ2N:N′

    Directory of Open Access Journals (Sweden)

    Bin Liu

    2011-12-01

    Full Text Available In the title complex, {[Cu(C11H8N2O2](BF42}n, the CuII ion is situated on an inversion centre and adopts an N4F2 octahedral coordination geometry with four N atoms from four different bis(pyridin-3-ylmethanone ligands at the equatorial sites and two independent tetrafluoridoborate anions weakly bonded at the axial sites via two F atoms [Cu...F = 2.613 (3 Å]. Chains with the bridging ligands are formed along the a axis. C—H...F interactions stabilize the structure. C—O...π interactions also occur.

  2. catena-Poly[[copper(II)-bis[μ-bis(3,5-dimethyl-1H-pyrazol-4-yl) selenide

    Science.gov (United States)

    Seredyuk, Maksym; Haukka, Matti; Pavlenko, Vadim A.; Fritsky, Igor O.

    2009-01-01

    In the title compound, {[Cu(C10H14N4Se)2](ClO4)2}n, the CuII ion is located on a twofold rotation axis and has a tetra­gonally distorted square-planar geometry constituted by four N atoms. A pair of bis(3,5-dimethyl-1H-pyrazol-4-yl) selenide (L) ligands bridges the copper centers into a polymeric chain extending along [001]. The perchlorate anions are involved in inter­molecular N—H⋯O hydrogen bonding, which links the chains into layers parallel to the bc plane. PMID:21578140

  3. catena-Poly[[copper(II-bis[μ-bis(3,5-dimethyl-1H-pyrazol-4-yl selenide

    Directory of Open Access Journals (Sweden)

    Maksym Seredyuk

    2009-11-01

    Full Text Available In the title compound, {[Cu(C10H14N4Se2](ClO42}n, the CuII ion is located on a twofold rotation axis and has a tetragonally distorted square-planar geometry constituted by four N atoms. A pair of bis(3,5-dimethyl-1H-pyrazol-4-yl selenide (L ligands bridges the copper centers into a polymeric chain extending along [001]. The perchlorate anions are involved in intermolecular N—H...O hydrogen bonding, which links the chains into layers parallel to the bc plane.

  4. ‘Transnationalising’ Ne Bis In Idem: How the Rule of Ne Bis In Idem Reveals the Principle of Personal Legal Certainty

    Directory of Open Access Journals (Sweden)

    Juliette Lelieur

    2013-09-01

    Full Text Available Since Article 54 of the Convention implementing the Schengen Agreement gave the rule of ne bis in idem a transnational dimension, talk of the ‘transnational ne bis in idem principle’ has been commonplace. Thus, when looking for general principles of transnational criminal law, scholars refer to the principle of ‘transnational ne bis in idem’. It is doubtful, however, that ne bis in idem qualifies as a principle of law. It should be regarded, rather, as a rule of criminal procedure, traditionally based on the principle of res judicata. Giving the rule of ne bis in idem a transnational dimension therefore requires either transnationalising the principle of res judicata, or giving the rule of ne bis in idem a new foundation.The principle of res judicata principally serves the credibility of the justice system in a given jurisdiction by prohibiting several tribunals, all acting within the parameters of their jurisdiction, from contradicting each other’s interpretation of the same facts. For this reason, the principle of res judicata does not provide an adequate basis for a transnationalised rule of ne bis in idem.From a human rights perspective, multiple prosecutions against the same person for the same facts collides with protecting individuals against arbitrary judicial treatment. This is true whether the multiple prosecutions all take place in one country or in several different countries. The rule of ne bis in idem could therefore be regarded as a manifestation of the (new ‘principle of personal legal certainty’.

  5. Revised Reinforcement Sensitivity Theory and Laboratory Assessment of BIS and BAS in Children

    Science.gov (United States)

    Colder, Craig R.; Trucco, Elisa M.; Lopez, Hector I.; Hawk, Larry W.; Read, Jennifer P.; Lengua, Liliana J.; Weiczorek, William F.; Eiden, Rina D.

    2011-01-01

    There is considerable interest in Gray’s reinforcement sensitivity theory. However, few measures of the behavioral approach (BAS) and inhibition systems (BIS) exist for children. Moreover, the theory was substantially revised a decade ago and measurement instruments are still largely based on the old theory. Our aim was to revise questionnaire and laboratory assessments of BIS and BAS for children. Performance on the Point Scoring Reaction Time Task for Children Revised (PSRTT-CR) conformed to theoretical expectations. Caregiver reports of BIS and BAS were associated with corresponding PSRTT-CR indices, suggesting cross-method convergent and discriminant validity. There was convergence with physiological correlates of BAS, but not physiological correlates of BIS. Overall, our revised measures represent promising instruments of children’s BIS and BAS. PMID:21603055

  6. The Cephalostatins 22. Synthesis of Bis-steroidal Pyrazine Pyrones

    Science.gov (United States)

    Pettit, George R.; Moser, Bryan R.; Mendonça, Ricardo F.; Knight, John C.; Hogan, Fiona

    2012-01-01

    Cephalostatin 1 (1), a remarkably strong cancer cell growth inhibitory trisdecacyclic, bis-steroidal pyrazine isolated from the marine tube worm Cephalodiscus gilchristi, continues to be an important target for practical total syntheses and a model for the discovery of less complex structural modifications with promising antineoplastic activity. In the present study, the cephalostatin E and F rings were greatly simplified by replacement at C-17 with an α-pyrone (in 12), typical of the steroidal bufodienolides, and by a dihydro-γ-pyrone (in 16). The synthesis of pyrazine 12 from 5α-dihydrotestosterone (nine steps, 8% overall yield) provided the first route to a bis-bufadienolide pyrazine. Dihydro-γ-pyrone 16 was synthesized in eight steps from ketone 13. While only insignificant cancer cell growth inhibitory activity was found for pyrones 12 and 16, the results provided further support for the necessity of more closely approximating the natural D–F ring system of cephalostatin 1 in order to obtain potent antineoplastic activity. PMID:22607450

  7. Selective electrolytic removal of bis(alkoxycarbonyl)methano addends from C60 bis-adducts and electrochemical stability of C70 derivatives

    Science.gov (United States)

    Kessinger; Fender; Echegoyen; Thilgen; Echegoyen; Diederich

    2000-06-16

    The novel mixed bis-adducts of C60, (+/-)-4-(+/-)-8 and 9, with a bis(ethoxycarbonyl)methano addend (Bingel addend) and a second addend ([1,2]benzeno, but[2]eno, methaniminomethano, or diarylmethano) bridging 6,6-closed bonds of the carbon sphere were synthesized in two-step reactions. Each bis-adduct was exhaustively electrolyzed at the potential of the second fullerene-centered reduction step, resulting in the selective removal of the Bingel addend (retro-Bingel reaction) to produce the corresponding mono-adducts, which were isolated in yields of over 60%. These results open up the possibility of using the Bingel addend as a temporary protecting and directing group in the construction of multiple adducts of C60 with unusual addition patterns. The Bingel-type mono-adduct of C70 10 and the constitutionally isomeric bis-adducts 11, (+/-)-12, and (+/-)-13 were also included in this investigation. A large difference in the electrochemical behavior between C70 bis-adducts and the corresponding C60 derivatives was observed. Thus, the intramolecular "walk-on-the-sphere" isomerization which occurs readily with Bingel-type bis-adducts of C60 under the conditions of two-electron controlled potential electrolysis (CPE) is only a minor reaction pathway in the series of C70 derivatives. The latter preferentially undergo retro-Bingel reaction.

  8. Oxovanadium(IV complexes of bioinorganic and medicinal relevance: Synthesis, characterization and 3D molecular modeling of some oxovanadium(IV complexes involving O, N-donor environment of salicylaldehyde-based sulfa drug Schiff bases

    Directory of Open Access Journals (Sweden)

    R.C. Maurya

    2016-11-01

    Full Text Available The present paper reports the synthesis and characterization of some new sulfa drug based Schiff base oxovanadium(IV complexes of composition, [VO(sal-sdz2(H2O]·H2O, [VO(sal-sgn2(H2O]·H2O, [VO(sal-snm(H2O]·H2O, [VO(sal-smr2(H2O]·H2O and [VO(dadps(H2O]2·2H2O, where sal-sdzH = N-(salicylidenesulfadizine, sal-sgnH = N-(salicylidenesulfaguanidine, sal-snmH = N-(salicylidenesulfanilamide, sal-smrH = N-(salicylidenesulfamerizine, sal-dadpsH2 = N,N′-bis(salicylidene-4,4′-diaminodiphenylsulfone, respectively. Complexes, (1–(4 were prepared by the reaction of VOSO4·5H2O with the Schiff bases in 1:2 metal-ligand ratio while complex (5 in 2:2 metal-ligand ratio in DMF-ethanol medium. The compounds so obtained were characterized by different physico-chemical studies, such as, elemental analysis, molar conductance and magnetic measurements, infrared, ESR, thermogravimetric studies, mass and electronic spectral studies. The overall IR studies conclude that the ligand in complex (1–(4 behave as monobasic bidentate ON donor, while the ligand in the complex (5 behaves as dibasic tetradentate O2N2 donor. The 3D-molecular modeling and analysis for bond lengths and bond angles have also been carried out for two representative compounds, [VO(sal-snm2(H2O]·H2O (3 and [VO(dadps(H2O]2·2H2O (5 to substantiate the proposed structures. Based on these studies suitable octahedral structures have been proposed for these complexes.

  9. Synthesis and reactivity of some octacoordinated dioxouranium(VI) complexes of diacetyl bis(benzoylhydrazone) and benzil bis(benzoylhydrazone)

    International Nuclear Information System (INIS)

    Maiti, Amalendu; Ghosh, Saktiprosad

    1989-01-01

    Octacoordinated dioxouranium(VI)complexes of the tetradentate ONNO donors diacetyl bis(benzoylhydrazone)(H 2 L) and benzil bis(benzoylhydrazone)(H 2 L') are reported. At low pH(1.5-2.5) complexes of the formula [UO 2 (H 2 L/H 2 L')X 2 ](X - =Cl - , Br - , NO 3 - , NCS - , ClO 4 - , OAc - or 0.5SO 4 2- )containing the ke-to form of the ligands are isolated. At higher pH(6-7), the complexes [UO 2 (L/L')(H 2 O) 2 are obtained in which the ligand is present in its deprotonated enolate form (L' 2 - or L' 2- ). Reactions of [UO 2 (H 2 L/H 2 L')X 2 ]/[UO 2 (L/L')(H 2 O) 2 ] with neutral monodentate (B) and bidentate lewis bases (AA) lead to the formation of mixed-ligand complexes of the type[UO 2 (L/L')(B) 2 ] and [UO 2 (L/L')(AA)] respectively. Results of elementa l analyses, magnetic susceptibility and conductivity measurements, spectroscopic (IR, electronic etc.) and thermal decomposition studies have been utilised to characterise the complexes. (author). 11 refs., 1 tab

  10. Validity and Reliability of the Abbreviated Barratt Impulsiveness Scale in Spanish (BIS-15S)*

    Science.gov (United States)

    Orozco-Cabal, Luis; Rodríguez, Maritza; Herin, David V.; Gempeler, Juanita; Uribe, Miguel

    2010-01-01

    Objective This study determined the validity and reliability of a new, abbreviated version of the Spanish Barratt Impulsiveness Scale (BIS-15S) in Colombian subjects. Method The BIS-15S was tested in non-clinical (n=283) and clinical (n=164) native Spanish-speakers. Intra-scale reliability was calculated using Cronbach’s α, and test-retest reliability was measured with Pearson correlations. Psychometric properties were determined using standard statistics. A factor analysis was performed to determine BIS-15S factor structure. Results 447 subjects participated in the study. Clinical subjects were older and more educated compared to non-clinical subjects. Impulsivity scores were normally distributed in each group. BIS-15S total, motor, non-planning and attention scores were significantly lower in non-clinical vs. clinical subjects. Subjects with substance-related disorders had the highest BIS-15S total scores, followed by subjects with bipolar disorders and bulimia nervosa/binge eating. Internal consistency was 0.793 and test-retest reliability was 0.80. Factor analysis confirmed a three-factor structure (attention, motor, non-planning) accounting for 47.87% of the total variance in BIS-15S total scores. Conclusions The BIS-15S is a valid and reliable self-report measure of impulsivity in this population. Further research is needed to determine additional components of impulsivity not investigated by this measure. PMID:21152412

  11. Relation between constructs of BisBas questionnaire and some personality constructs

    Directory of Open Access Journals (Sweden)

    Nataša Sedlar

    2008-04-01

    Full Text Available The goal of this study was to examine relation between constructs relevant for Gray's neuropsychological model of motivation. According to Gray's theory, two general motivational systems underlie behavior and affect: a behavioral inhibition system (BIS and a behavioral activation system (BAS. BIS is sensitive to aversive stimuli, causes avoidance behaviors and is responsible for individual differences in anxiety. BAS is responsive to appetitive stimuli, triggers approach behavior and has been associated with individual differences in impulsivness. BIS activity has been related to the experience of negative emotions, whereas BAS activity has been associated with the experience of positive emotions. A total of 122 Slovenian students, aged 17–19 years, completed the BIS/BAS scale, the Impulsiveness-Venturesome-Empathy Scale IVE, State Trait Anxiety Inventory STAI-X2, The Positive and Negative Affect Schedule PANAS, and The Big Five Questionairre BFQ. Our results are consistent with those from recent empirical studies and provide support for Gray's theory. Measures of BIS were found to be positively related to trait anxiety and neuroticism, whereas measures of BAS were found to be positively related to impulsiveness and extraversion. Emotional component measured with PANAS did not distinguish BIS from BAS constructs. Both were found to be related to negative affect. With respect to construct validity these findings suggest that BIS/BAS scale is reasonably effective.

  12. Crystalline Bis-urea Nanochannel Architectures Tailored for Single-File Diffusion Studies.

    Science.gov (United States)

    Bowers, Clifford R; Dvoyashkin, Muslim; Salpage, Sahan R; Akel, Christopher; Bhase, Hrishi; Geer, Michael F; Shimizu, Linda S

    2015-06-23

    Urea is a versatile building block that can be modified to self-assemble into a multitude of structures. One-dimensional nanochannels with zigzag architecture and cross-sectional dimensions of only ∼3.7 Å × 4.8 Å are formed by the columnar assembly of phenyl ether bis-urea macrocycles. Nanochannels formed by phenylethynylene bis-urea macrocycles have a round cross-section with a diameter of ∼9.0 Å. This work compares the Xe atom packing and diffusion inside the crystalline channels of these two bis-ureas using hyperpolarized Xe-129 NMR. The elliptical channel structure of the phenyl ether bis-urea macrocycle produces a Xe-129 powder pattern line shape characteristic of an asymmetric chemical shift tensor with shifts extending to well over 300 ppm with respect to the bulk gas, reflecting extreme confinement of the Xe atom. The wider channels formed by phenylethynylene bis-urea, in contrast, present an isotropic dynamically average electronic environment. Completely different diffusion dynamics are revealed in the two bis-ureas using hyperpolarized spin-tracer exchange NMR. Thus, a simple replacement of phenyl ether with phenylethynylene as the rigid linker unit results in a transition from single-file to Fickian diffusion dynamics. Self-assembled bis-urea macrocycles are found to be highly suitable materials for fundamental molecular transport studies on micrometer length scales.

  13. Neuroprotective effects of bis(7-tacrine against glutamate-induced retinal ganglion cells damage

    Directory of Open Access Journals (Sweden)

    Xu Zhi

    2010-03-01

    Full Text Available Abstract Background Glutamate-mediated excitotoxicity, primarily through N-methyl-D-aspartate (NMDA receptors, may be an important cause of retinal ganglion cells (RGCs death in glaucoma and several other retinal diseases. Bis(7-tacrine is a noncompetitive NMDA receptors antagonist that can prevent glutamate-induced hippocampal neurons damage. We tested the effects of bis(7-tacrine against glutamate-induced rat RGCs damage in vitro and in vivo. Results In cultured neonatal rats RGCs, the MTT assay showed that glutamate induced a concentration- and time-dependent toxicity. Bis(7-tacrine and memantine prevented glutamate-induced cell death in a concentration-dependent manner with IC50 values of 0.028 μM and 0.834 μM, respectively. The anti-apoptosis effects of bis(7-tacrine were confirmed by annexin V-FITC/PI staining. In vivo, TUNEL analysis and retrograde labeling analysis found that pretreatment with bis(7-tacrine(0.2 mg/kg induced a significant neuroprotective effect against glutamate-induced RGCs damage. Conclusions Our results showed that bis(7-tacrine had neuroprotective effects against glutamate-induced RGCs damage in vitro and in vivo, possibly through the drug's anti-NMDA receptor effects. These findings make bis(7-tacrine potentially useful for treating a variety of ischemic or traumatic retinopathies inclusive of glaucoma.

  14. A triclinic polymorph of poly[[bis[μ-1,2-bis(pyridin-4-ylethene-κ2N:N′]bis(thiocyanato-κNcobalt(II] 1,2-bis(pyridin-4-ylethene monosolvate

    Directory of Open Access Journals (Sweden)

    Susanne Wöhlert

    2012-06-01

    Full Text Available In the crystal structure of the title compound, [Co(NCS2(C12H10N22]·C12H10N2, the CoII cations are octahedrally coordinated by two terminally N-bonded thiocyanate anions and four 1,2-bis(pyridin-4-ylethene (bpe ligands. The asymmetric unit consists of three crystallographically independent CoII cations, six thiocyanate anions and six coordinating bpe ligands in general positions. Additionally, three non-coordinating bpe ligands are present in the asymmetric unit with two of them located on a center of inversion. The CoII cations are connected by the bpe ligands into layers parallel to the bc plane. The crystal investigated was non-merohedrically twinned, with a fractional contribution of 0.261 (2 for the minor domain.

  15. Conformational Restriction of Peptides Using Dithiol Bis-Alkylation.

    Science.gov (United States)

    Peraro, L; Siegert, T R; Kritzer, J A

    2016-01-01

    Macrocyclic peptides are highly promising as inhibitors of protein-protein interactions. While many bond-forming reactions can be used to make cyclic peptides, most have limitations that make this chemical space challenging to access. Recently, a variety of cysteine alkylation reactions have been used in rational design and library approaches for cyclic peptide discovery and development. We and others have found that this chemistry is versatile and robust enough to produce a large variety of conformationally constrained cyclic peptides. In this chapter, we describe applications, methods, mechanistic insights, and troubleshooting for dithiol bis-alkylation reactions for the production of cyclic peptides. This method for efficient solution-phase macrocyclization is highly useful for the rapid production and screening of loop-based inhibitors of protein-protein interactions. © 2016 Elsevier Inc. All rights reserved.

  16. SYNTHESIS, CHARACTERIZATION AND CRYSTAL STRUCTURE OF BIS-(2-HYDROXYBENZALDEHYDEDIAMINOGUANIZONE

    Directory of Open Access Journals (Sweden)

    Diana Dragancea, Vladimir B. Arion, Sergiu Shova

    2008-12-01

    Full Text Available The new ligand, bis(2-hydroxybenzaldehydediaminoguanizone (1 has been synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopies. The crystal structure of the compound was determined by X-ray diffraction. The ligand C15H15N5O2·C2H5OH crystallizes in the monoclinic space group P21/c with unit cell parameters a = 8.9102(3, b = 10.0357(3, c = 19.7618(6 Å, β = 98.385(2°, Z = 4, V = 1748.21(9 Å3, R1 = 0.040. The amino form of the ligand adopts a planar conformation stabilized by two intramolecular hydrogen bonds of the type O–H···N, in which the H atoms of the central amino group are directed to the lone-pair regions of the azomethine nitrogen atoms.

  17. Ultrathin polycrystalline 6,13-Bis(triisopropylsilylethynyl)-pentacene films

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Min-Cherl; Zhang, Dongrong; Nikiforov, Gueorgui O.; Lee, Michael V.; Qi, Yabing, E-mail: Yabing.Qi@oist.jp [Energy Materials and Surface Sciences Unit (EMSS), Okinawa Institute of Science and Technology Graduate University (OIST), 1919-1 Tancha, Onna-son, Okinawa 904-0495 (Japan); Joo Shin, Tae; Ahn, Docheon; Lee, Han-Koo; Baik, Jaeyoon; Shin, Hyun-Joon [Pohang Accelerator Laboratory, POSTECH, Pohang 790-784 (Korea, Republic of)

    2015-03-15

    Ultrathin (<6 nm) polycrystalline films of 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS-P) are deposited with a two-step spin-coating process. The influence of spin-coating conditions on morphology of the resulting film was examined by atomic force microscopy. Film thickness and RMS surface roughness were in the range of 4.0–6.1 and 0.6–1.1 nm, respectively, except for small holes. Polycrystalline structure was confirmed by grazing incidence x-ray diffraction measurements. Near-edge x-ray absorption fine structure measurements suggested that the plane through aromatic rings of TIPS-P molecules was perpendicular to the substrate surface.

  18. Conductivity of oriented bis-azo polymer films

    DEFF Research Database (Denmark)

    Apitz, D.; Bertram, R.P.; Benter, N.

    2006-01-01

    The conductivity properties of electro-optic photoaddressable, dense bis-ozo chromophore polymer films are investigated by using samples corona poled at various temperatures. A dielectric spectrometer is applied to measure the frequency dependence of the conductivity at different temperatures...... before and after heating the material to above the glass transition temperature. The results show that the orientation of the chromophores changes the charge-carrier mobility. Ionic conductivity dominates in a more disordered configuration of the material, while the competing process of hole hopping...... takes over as a transition to a liquid-crystalline phase occurs when the material is heated to much higher than the gloss transition temperature. Such micro-crystallization strongly enhances the conductivity....

  19. Macrocyclic bis-quinolizidine alkaloids from Xestospongia muta.

    Science.gov (United States)

    Dung, Duong Thi; Hang, Dan Thi Thuy; Yen, Pham Hai; Quang, Tran Hong; Nhiem, Nguyen Xuan; Tai, Bui Huu; Minh, Chau Van; Kim, Youn-Chul; Kim, Dong Cheol; Oh, Hyuncheol; Kiem, Phan Van

    2018-03-29

    A new stereoisomer Meso-araguspongine C together with nine reported macrocyclic bis-quinolizidine alkaloids araguspongines A, C, E, L, N-P, petrosin, and petrosin A were isolated from marine sponge Xestospongia muta. Stereochemistry of meso-araguspongine C (2) and araguspongines N-P (3-5) were established by their NMR data and conformational analyses. Both araguspongine C (1) and meso-araguspongine C (2) exhibited great cytotoxic activity towards HepG-2, HL-60, LU-1, MCF-7, and SK-Mel-2 human cancer cells (IC 50 in the range of 0.43-1.02 μM). At a concentration of 20 μM, isolated compounds (1-10) also showed modest inhibitory effects (from 7.6 to 40.8%) on the NO production in LPS activated RAW264.7 macrophages.

  20. Non-Heme Iron Catalysts with a Rigid Bis-Isoindoline Backbone and Their Use in Selective Aliphatic C−H Oxidation

    NARCIS (Netherlands)

    Chen, Jianming; Lutz, Martin; Milan, Michela; Costas, Miquel; Otte, Matthias; Klein Gebbink, Bert

    2017-01-01

    Iron complexes derived from a bis-isoindoline-bis-pyridine ligand platform based on the BPBP ligand (BPBP=N,N′-bis(2-picolyl)-2,2′-bis-pyrrolidine) have been synthesized and applied in selective aliphatic C−H oxidation with hydrogen peroxide under mild conditions. The introduction of benzene

  1. Neuroprotective copper bis(thiosemicarbazonato complexes promote neurite elongation.

    Directory of Open Access Journals (Sweden)

    Laura Bica

    Full Text Available Abnormal biometal homeostasis is a central feature of many neurodegenerative disorders including Alzheimer's disease (AD, Parkinson's disease (PD, and motor neuron disease. Recent studies have shown that metal complexing compounds behaving as ionophores such as clioquinol and PBT2 have robust therapeutic activity in animal models of neurodegenerative disease; however, the mechanism of neuroprotective action remains unclear. These neuroprotective or neurogenerative processes may be related to the delivery or redistribution of biometals, such as copper and zinc, by metal ionophores. To investigate this further, we examined the effect of the bis(thiosemicarbazonato-copper complex, Cu(II(gtsm on neuritogenesis and neurite elongation (neurogenerative outcomes in PC12 neuronal-related cultures. We found that Cu(II(gtsm induced robust neurite elongation in PC12 cells when delivered at concentrations of 25 or 50 nM overnight. Analogous effects were observed with an alternative copper bis(thiosemicarbazonato complex, Cu(II(atsm, but at a higher concentration. Induction of neurite elongation by Cu(II(gtsm was restricted to neurites within the length range of 75-99 µm with a 2.3-fold increase in numbers of neurites in this length range with 50 nM Cu(II(gtsm treatment. The mechanism of neurogenerative action was investigated and revealed that Cu(II(gtsm inhibited cellular phosphatase activity. Treatment of cultures with 5 nM FK506 (calcineurin phosphatase inhibitor resulted in analogous elongation of neurites compared to 50 nM Cu(II(gtsm, suggesting a potential link between Cu(II(gtsm-mediated phosphatase inhibition and neurogenerative outcomes.

  2. Bis-pyrene-modified unlocked nucleic acids: synthesis, hybridization studies, and fluorescent properties

    DEFF Research Database (Denmark)

    Perlíková, Pavla; Ejlersen, Maria; Langkjaer, Niels

    2014-01-01

    Efficient synthesis of a building block for the incorporation of a bis-pyrene-modified unlocked nucleic acid (UNA) into oligonucleotides (DNA*) was developed. The presence of bis-pyrene-modified UNA within a duplex leads to duplex destabilization that is more profound in DNA*/RNA and less distinct......)uracil:pyrene exciplex emission in the single-stranded form. Such fluorescent properties enable the application of bis-pyrene-modified UNA in the development of fluorescence probes for DNA/RNA detection and for detection of deletions at specific positions....

  3. Gray's BIS/BAS dimensions in non-comorbid, non-medicated social anxiety disorder.

    Science.gov (United States)

    Morgan, Barak E; van Honk, Jack; Hermans, Erno J; Scholten, Marjon R M; Stein, Dan J; Kahn, Rene S

    2009-01-01

    Gray's behavioural inhibition and behavioural activation (BIS/BAS) neural systems model has led to research on approach and withdrawal as the two most fundamental dimensions of affective behaviour, and their role in psychopathology. Although Gray proposed the BIS as the neurological basis of anxiety, there are no reports examining approach and withdrawal predispositions in social anxiety disorder. Here we report approach and withdrawal predispositions in a group of 23 non-medicated individuals with social anxiety disorder (SAD) without co-morbid depression and in 48 normal controls. Results show increased BIS and decreased BAS fun-seeking in SAD subjects thereby underscoring Gray's dimensional model.

  4. DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles.

    Science.gov (United States)

    Atwell, G J; Fan, J Y; Tan, K; Denny, W A

    1998-11-19

    A series of bis(hydroxymethyl)-substituted imidazoles, thioimidazoles, and pyrrolizines and related bis(carbamates), linked to either 9-anilinoacridine (intercalating) or 4-(4-quinolinylamino)benzamide (minor groove binding) carriers, were synthesized and evaluated for sequence-specific DNA alkylation and cytotoxicity. The imidazole and thioimidazole analogues were prepared by initial synthesis of [(4-aminophenyl)alkyl]imidazole-, thioimidazole-, or pyrrolizine dicarboxylates, coupling of these with the desired carrier, and reduction to give the required bis(hydroxymethyl) alkylating moiety. The pyrrolizines were the most reactive alkylators, followed by the thioimidazoles, while the imidazoles were unreactive. The pyrrolizines and some of the thioimidazoles cross-linked DNA, as measured by agarose gel electrophoresis. Strand cleavage assays showed that none of the compounds reacted at purine N7 or N3 sites in the gpt region of the plasmid gpt2Eco, but the polymerase stop assay showed patterns of G-alkylation in C-rich regions. The corresponding thioimidazole bis(carbamates) were more selective than the bis(hydroxymethyl) pyrrolizines, with high-intensity bands at 5'-NCCN, 5'-NGCN and 5'-NCGN sequences in the PCR stopping assay ( indicates block sites). The data suggest that these targeted compounds, like the known thioimidazole bis(carbamate) carmethizole, alkylate exclusively at guanine residues via the 2-amino group, with little or no alkylation at N3 and N7 guanine or adenine sites. The cytotoxicities of the compounds correlated broadly with their reactivities, with the bis(hydroxymethyl)imidazoles being the least cytotoxic (IC50s >1 microM; P388 leukemia) and with the intercalator-linked analogues being more cytotoxic than the corresponding minor-groove-targeted ones. This was true also for the more reactive thioimidazole bis(carbamates) (IC50s 0.8 and 11 microM, respectively), but both were more active than the analogous "untargeted" carmethizole (IC50 20

  5. Effect of three bis-pyridyl-bis-amide ligands with various spacers on the structural diversity of new multifunctional cobalt(II) coordination polymers

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Hong-Yan [Department of Chemistry, Bohai University, Jinzhou 121000 (China); Lu, Huizhe [Department of Applied Chemistry, China Agricultural University, Beijing, 100193 (China); Le, Mao; Luan, Jian [Department of Chemistry, Bohai University, Jinzhou 121000 (China); Wang, Xiu-Li, E-mail: wangxiuli@bhu.edu.cn [Department of Chemistry, Bohai University, Jinzhou 121000 (China); Liu, Guocheng; Zhang, Juwen [Department of Chemistry, Bohai University, Jinzhou 121000 (China)

    2015-03-15

    Three new cobalt(II) coordination polymers [Co{sub 2}(1,4-NDC){sub 2}(3-bpye)(H{sub 2}O)] (1), [Co(1,4-NDC)(3-bpfp)(H{sub 2}O)] (2) and [Co(1,4-NDC)(3-bpcb)] (3) [3-bpye=N,N′-bis(3-pyridinecarboxamide)-1,2-ethane, 3-bpfp=bis(3-pyridylformyl)piperazine, 3-bpcb=N,N′-bis(3-pyridinecarboxamide)-1,4-benzene, and 1,4-H{sub 2}NDC=1,4-naphthalenedicarboxylic acid] have been hydrothermally synthesized. The structures of complexes 1–3 have been determined by X-ray single crystal diffraction analyses and further characterized by infrared spectroscopy (IR), powder X-ray diffraction (PXRD) and thermogravimetric analyses (TGA). Complex 1 is a 3D coordination structure with 8-connected (4{sup 20}.6{sup 8}) topology constructed from 3D [Co{sub 2}(1,4-NDC){sub 2}(H{sub 2}O)]{sub n} framework and bidentate 3-bpye ligands. Complex 2 shows 1D “cage+cage”-like chain formed by 1D [Co{sub 2}(1,4-NDC){sub 2}]{sub n} ribbon chains and [Co{sub 2}(3-bpfp){sub 2}] loops, which are further linked by hydrogen bonding interactions to form a 3D supramolecular network. Complex 3 displays a 3D coordination network with a 6-connected (4{sup 12}.6{sup 3}) topology based on 2D [Co{sub 2}(1,4-NDC){sub 2}]{sub n} layers and bidentate 3-bpcb bridging ligands. The influences of different bis-pyridyl-bis-amide ligands with various spacers on the structures of title complexes are studied. Moreover, the fluorescent properties, electrochemical behaviors and magnetic properties of complexes 1–3 have been investigated. - Graphical abstract: Three multifunctional cobalt(II) complexes constructed from three bis-pyridyl-bis-amide and 1,4-naphthalenedicarboxylic acid have been hydrothermally synthesized and characterized. The fluorescent, electrochemical and magnetic properties of 1–3 have been investigated. - Highlights: • Three multifunctional cobalt(II) complexes based on various bis-pyridyl-bis-amide ligands. • Complex 1 is a 3D coordination structure with 8-connected (4{sup 20}.6{sup 8

  6. catena-Poly[[[aquacopper(II]bis[μ-bis(3,5-dimethyl-1H-pyrazol-4-yl selenide

    Directory of Open Access Journals (Sweden)

    Maksym Seredyuk

    2010-05-01

    Full Text Available The title compound, {[Cu(C10H14N4Se2(H2O](BF42·2C18H15PO·H2O}n, has a polymeric structure where each CuII ion adopts a square-pyramidal coordination constituted by four N atoms of pyrazole moieties in the equatorial plane and an axial O atom of a water molecule. A pair of bis(3,5-dimethyl-1H-pyrazol-4-yl selenide ligands bridges the CuII centres into a chain extending along the c axis. The water molecules, anions and triphenylphosphine oxide molecules are involved in intermolecular hydrogen bonding, which links the chains into a three-dimensional network.

  7. Partitioning of Minor Actinides from High Active Raffinates using Bis-Diglycol-amides (BisDGA) as new efficient Extractants

    Energy Technology Data Exchange (ETDEWEB)

    Modolo, G.; Vijgen, H. [Forschungszentrum Juelich GmbH, Institute for Energy Research, Safety Research and Reactor Technology, 52425 Juelich (Germany); Espartero, A.G. [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Avda. Complutense 22, 28040-Madrid (Spain); Prados, P. [Departamento de Quimica Organica, Facultad de Ciencias, Universidad Autonoma de Madrid - UAM, carretera de Colmenar Viejo km 15.3, 28049-Madrid (Spain); Mendoza, J. de [Departamento de Quimica Organica, Facultad de Ciencias, Universidad Autonoma de Madrid - UAM, carretera de Colmenar Viejo km 15.3, 28049-Madrid (Spain); Institut Catala d' Investigacio Quimica (ICIQ) Av. Paisos Catalans 16, 43007-Tarragona (Spain)

    2008-07-01

    Two new polyamide extractants has been selected, namely UAM-069 and UAM-081, both synthesized at the University of Madrid (UAM), to develop a new separation process. These two ligands are bis-diglycol-amides, consisting of two diglycol-amides moieties grafted on an aromatic platform (UAM-069) or on an aliphatic linker (UAM-081), respectively. The extraction of actinides and fission products was studied from synthetic PUREX raffinate. Actinides(III) and lanthanides(III) are highly extracted from acidities > 1 mol/L HNO{sub 3}. The extraction of Zr, Mo and Pd could be suppressed with complexing agents such as oxalic acid and HEDTA. In the present paper the results of the batch extraction results are presented which serve for the development of a new continuous counter current process to be tested in centrifugal contactors. (authors)

  8. Crystal structure of 1,4-bis(3-ammoniopropylpiperazine-1,4-diium bis[dichromate(VI

    Directory of Open Access Journals (Sweden)

    S. Vetrivel

    2016-05-01

    Full Text Available The asymmetric unit of the organic–inorganic title salt, (C10H28N4[Cr2O7]2, comprises one half of an 1,4-bis(3-ammoniopropylpiperazinediium cation (the other half being generated by the application of inversion symmetry and a dichromate anion. The piperazine ring of the cation adopts a chair conformation, and the two CrO4 tetrahedra of the anion are in an almost eclipsed conformation. In the crystal, the cations and anions form a layered arrangement parallel to (001. N—H...O hydrogen bonds between the cations and anions and additional C—H...O interactions lead to the formation of a three-dimensional network structure.

  9. Iodide Selective Electrodes Based on Bis(2-mercaptobenzothiazolato Mercury(II and Bis(4-chlorothiophenolato Mercury(II Carriers

    Directory of Open Access Journals (Sweden)

    Morteza M. Zohory

    2003-12-01

    Full Text Available New iodide-selective electrodes based on bis(2-mercaptobenzothiazolato mercury(II [Hg(MBT2] and bis(4-chlorothiophenolato mercury(II [Hg(CTP2] carriers are described. The electrodes were prepared by incorporating the ionophores into plasticized PVC membranes, which were directly coated on the surface of graphite disk electrodes. The electrodes displayed high selectivity for iodide with respect to a number of inorganic and organic anions. The influence of the membrane composition and pH, and the effect of lipophilic cationic and anionic additives on the response properties of the electrodes were investigated. The electrodes exhibited near-Nernstian slopes of -57.6 ± 0.8 and -58.4 ± 1.4 mV/decade of iodide concentration over the range 1 × 10-6 – 1 × 10-1 M, with detection limits of ~4 × 10-7 and 6 × 10-7 M for the electrodes based on [Hg(MBT2] and [Hg(CTP2], respectively. They have relatively fast response times (≤ 10 s, satisfactory reproducibility, and life times of at least two months. The potentiometric responses of the electrodes are independent of pH of the test solution over the range 3.5 – 11.5.

  10. Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation.

    OpenAIRE

    Jänne, J; Morris, D R

    1984-01-01

    Several congeners of methylglyoxal bis(guanylhydrazone) were tested for their ability to inhibit eukaryotic putrescine-activated S-adenosylmethionine decarboxylase (EC 4.1.1.50) and intestinal diamine oxidase (EC 1.4.3.6). All the compounds tested, namely methylglyoxal bis(guanylhydrazone), ethylglyoxal bis(guanylhydrazone), dimethylglyoxal bis(guanylhydrazone) and the di-N"-methyl derivative of methylglyoxal bis(guanylhydrazone), were strong inhibitors of both yeast and mouse liver adenosylm...

  11. BIS impulsivity and acute nicotine exposure are associated with discounting global consequences in the Harvard game.

    Science.gov (United States)

    Hogarth, Lee; Stillwell, David J; Tunney, Richard J

    2013-01-01

    The Barratt Impulsivity Scale (BIS) provides a transdiagnostic marker for a number of psychiatric conditions and drug abuse, but the precise psychological trait(s) tapped by this questionnaire remain obscure. To address this, 51 smokers completed in counterbalanced order the BIS, a delay discounting task and a Harvard game that measured choice between a response that yielded a high immediate monetary payoff but decreased opportunity to earn money overall (local choice) versus a response that yielded a lower immediate payoff but afforded a greater opportunity to earn overall (global choice). Individual level of BIS impulsivity and self-elected smoking prior to the study were independently associated with increased preference for the local over the global choice in the Harvard game, but not delay discounting. BIS impulsivity and acute nicotine exposure reflect a bias in the governance of choice by immediate reward contingencies over global consequences, consistent with contemporary dual-process instrumental learning theories. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Divergence in Ynone Reactivity: Atypical Cyclization by 3,4-Difunctionalization versus Rare Bis(cyclization).

    Science.gov (United States)

    Almendros, Pedro; Alcaide, Benito; Lázaro-Milla, Carlos; Delgado-Martínez, Patricia

    2018-04-06

    Functionalized ynones can be activated by in situ generated Tf2C=CH2 to form zwitterionic species, which were trapped in an intramolecular fashion by several nucleophiles to generate in a divergent way two main types of triflones. Through fine-tuning the temperature, bis(triflyl)-6-membered- or (triflyl)-5-membered-fused-heterocycles were achieved in reasonable yields in a totally selective manner. In this way, bis(triflyl)flavones, bis(triflyl)thioflavones, bis(triflyl)selenoflavones, (triflyl)benzothienopyrans, (triflyl)benzoselenophenopyrans, (triflyl)vinyl aurones, and (triflyl)pyranoindoles were built. Conceivable mechanistic proposals were suggested based in the isolation of several intermediates and control experiments. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. [Stefan Hartmann. Revaler Handwerker im Spiegel fer Ratsprotokolle von 1722 bis 1755] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2007-01-01

    Arvustus: Stefan Hartmann. Revaler Handwerker im Spiegel fer Ratsprotokolle von 1722 bis 1755. In : Ostseeprovinzen, baltische Staaten und das Nationale. Münster : LIT, 2005. lk. 89-112. Kanuti gildi koondunud ametite organisatsioonist ja struktuurist

  14. Bis(sulfonamide) transmembrane carriers allow pH-gated inversion of ion selectivity.

    Science.gov (United States)

    Roy, Arundhati; Biswas, Oindrila; Talukdar, Pinaki

    2017-03-09

    Bis(sulfonamide) based synthetic carriers are reported for inversion of ion selectivity upon deviation of pH within a narrow window. A liposomal membrane potential is also generated when potassium ions are passively transported by these carriers.

  15. [Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Karin Hallas. Das Tallinner Mietshaus. Vom Historismus bis zum Jugendstil. In: Architektur und bildende Kunst im Baltikum um 1900. Frankfurt am Main, Berlin, Bern, Bruxelles, New York, Wien: Lang 1999. S. 173-192.

  16. 77 FR 66951 - Proposed Information Collection; Comment Request; BIS Program Evaluation

    Science.gov (United States)

    2012-11-08

    ... Jennifer Jessup, Departmental Paperwork Clearance Officer, Department of Commerce, Room 6616, 14th and... and instructions should be directed to Larry Hall, BIS ICB Liaison, (202) 482-4895, Lawrence[email protected

  17. Direct observation of supported W bis-methylidene from supported W-methyl/methylidyne species

    KAUST Repository

    Callens, Emmanuel

    2014-01-01

    Extensive solid-state NMR analyses unambiguously determine the formation of silica supported W bis-methylidene methyl species by reaction of the corresponding methyl carbyne with trimethylphosphine or a cyclic olefin. © 2014 the Partner Organisations.

  18. Structural Studies of 2,6-Diacetyl- and 2,6-Diformylpyridine Bis(thiosemicarbazones

    Directory of Open Access Journals (Sweden)

    Brown Christine A.

    2002-01-01

    Full Text Available Although a large number of crystal structures of heterocyclic thiosemicarbazones have recently appeared in the literature, few structures of heterocyclic bis(thiosemicarbazones or their metal complexes have been reported. Complexes of iron(II, indium(III, tin(IV, bismuth(III involve bis(thiosemicarbazones coordinating as N3S2 pentadentate ligands, often resulting in 7-coordinate complexes. In contrast, complexes with zinc(II are often binuclear with thiosemicarbazone moieties of a bis(thiosemicarbazone coordinating to two different zinc centers. Also included in this study is the structure of the first complex with a 2,6-diformylpyridine bis(thiosemicarbazone ligand, a 4-coordinate nickel(II complex with unusual coordination.

  19. Studies on trivalent lanthanide complexes of bis-vanillin p-phenylenediamine

    International Nuclear Information System (INIS)

    Shahma, Abu; Ahmad, Naseer

    1983-01-01

    The coordination interaction of lanthanide(III) chlorides with bis-vanillin o-phenylenediamine was studied by Ansari and Ahmad (1977). It was thought fruitful to compare these with the complexes of trivalent lanthanide ions with bis-vanillin p-phenylenediamine. The newly synthesized complexes were subjected to elemental, thermogravimetric and differential thermal analyses and their melting points, magnetic susceptibilities, molar conductances determined and infrared and electronic spectra taken. (author)

  20. Polen vor der Middle-Income-Trap? Entwicklungsplan bis 2030 soll den Aufholprozess beschleunigen

    OpenAIRE

    Holtemöller, Oliver; Kämpfe, Martina

    2017-01-01

    Polen hat seinen Abstand gegenüber den entwickelten Marktwirtschaften Westeuropas seit dem Beginn der 1990er Jahre bis heute gemessen am Pro-Kopf-Einkommen stark verringert. Galt das Land in den ersten zwei Jahrzehnten unter den mittelosteuropäischen Ländern als Vorreiter beim Wirtschaftswachstum, so hat sich das Aufholtempo in den letzten Jahren verlangsamt. Die polnische Regierung reagierte darauf mit einem strategischen Entwicklungsplan ('Morawiecki'-Plan), der Maßnahmen und Ziele bis 2030...

  1. Microwave-promoted synthesis of bicyclic azocine-β-lactams from bis(allenes).

    Science.gov (United States)

    Alcaide, Benito; Almendros, Pedro; Aragoncillo, Cristina; Fernández, Israel; Gómez-Campillos, Gonzalo

    2014-08-01

    A metal-free preparation of structurally novel bicyclic azocine-β-lactams has been developed. The first examples accounting for the preparation of eight-membered rings from bis(allenes) in the absence of metals have been achieved by the thermolysis of nonconjugated 2-azetidinone-tethered bis(allenes) on application of microwave irradiation. This selective carbocyclization reaction has been studied experimentally, and additionally, its mechanism has been investigated by a DFT study.

  2. Synthesis of bis-quinoxaline derivatives using Tonsil clay as a catalyst

    African Journals Online (AJOL)

    ... 9-ethyl-3,6-di(1,2-dioxoethyl)carbazole in the presence of Tonsil clay, a readily available and inexpensive catalyst. The structures of all new products were identified by 1H-NMR, 13C-NMR and FT-IR spectral data and microanalysis. KEY WORDS: bis-Quinoxaline, bis-Glyoxal, Green chemistry, 1,2-Diamine, Tonsil clay.

  3. A cytotoxic study of eugenol and its ortho dimer (bis-eugenol)

    Energy Technology Data Exchange (ETDEWEB)

    Kashiwagi, Yasushi [Meikai Univ., Sakado, Saitama (Japan). School of Dentistry

    2000-07-01

    Eugenol is widely used not only as a dental material such as pulp capping material, provisional cement, root canal sealer, and impression paste, but also as a perfume ingredients. Eugenol has antioxidant, bactericidal, and sedative activities, inhibits and non-enzymatic peroxidation. It was previously reported that eugenol exhibited the cytotoxic activity toward pulp cells and gingial fibroblasts and also that the cytotoxic activity was predominantly performed by radicals derived from the oxidation of eugenol. This study was based on the hypothesis that the toxicity of eugenol may be greately reduced if the radicalization of eugenol was diminished by the dimerization of eugenol. Thus, bis-eugenol, the dimer of eugenol, was synthesized to characterize the effect of this eugenol-related compound. The cytotoxic activity of bis-eugenol against human gingival fibroblasts (HGF cell) or human submandibular gland cancer cells (HSG cell) was studied in the presence or absence of light irradiation (visible or ultraviolet light), and compared with that of eugenol. The cytotoxic activity of eugenol was significantly greater than that of bis-eugenol. The cytotoxic activity of irradiated eugenol, but not that of irradiated bis-eugenol, was significantly higher than that of the non-irradiated counterpart. Bis-eugenol at a relatively low concentration declined the phototoxic activity of irradiation on living cells. Also, the generation of reactive oxygen in HSG cells in the ab-sence or the presence of irradiated bis-eugenol or eugenol was evaluated by an ACAS laser cytometry, and the results indicated that eugenol, but not bis-eugenol, generated reactive oxygen in the cells. The DPPH-radical scavenging activity of bis-eugenol was larger than that of eugenol. Furthermore, eugenol had a positive apoptosis-inducing effect on HSG cells. The structure-activity relationships of eugenol-related compounds showed that the nature of the substituent at the ortho or para-position of eugenol

  4. A cytotoxic study of eugenol and its ortho dimer (bis-eugenol)

    International Nuclear Information System (INIS)

    Kashiwagi, Yasushi

    2000-01-01

    Eugenol is widely used not only as a dental material such as pulp capping material, provisional cement, root canal sealer, and impression paste, but also as a perfume ingredients. Eugenol has antioxidant, bactericidal, and sedative activities, inhibits and non-enzymatic peroxidation. It was previously reported that eugenol exhibited the cytotoxic activity toward pulp cells and gingial fibroblasts and also that the cytotoxic activity was predominantly performed by radicals derived from the oxidation of eugenol. This study was based on the hypothesis that the toxicity of eugenol may be greately reduced if the radicalization of eugenol was diminished by the dimerization of eugenol. Thus, bis-eugenol, the dimer of eugenol, was synthesized to characterize the effect of this eugenol-related compound. The cytotoxic activity of bis-eugenol against human gingival fibroblasts (HGF cell) or human submandibular gland cancer cells (HSG cell) was studied in the presence or absence of light irradiation (visible or ultraviolet light), and compared with that of eugenol. The cytotoxic activity of eugenol was significantly greater than that of bis-eugenol. The cytotoxic activity of irradiated eugenol, but not that of irradiated bis-eugenol, was significantly higher than that of the non-irradiated counterpart. Bis-eugenol at a relatively low concentration declined the phototoxic activity of irradiation on living cells. Also, the generation of reactive oxygen in HSG cells in the ab-sence or the presence of irradiated bis-eugenol or eugenol was evaluated by an ACAS laser cytometry, and the results indicated that eugenol, but not bis-eugenol, generated reactive oxygen in the cells. The DPPH-radical scavenging activity of bis-eugenol was larger than that of eugenol. Furthermore, eugenol had a positive apoptosis-inducing effect on HSG cells. The structure-activity relationships of eugenol-related compounds showed that the nature of the substituent at the ortho or para-position of eugenol

  5. Temperature induced reversible polymorphic phase transformations in a bis-hydrazone compound

    Science.gov (United States)

    Jayant, Vikrant; Das, Dinabandhu

    2018-03-01

    Two reversible polymorphic phase transformation of 2,3-butanedione, 2,3- bis[4,4‧-bis(diethylamino)benzophenone hydrazone] (DEBH) have been identified in DSC experiment. Topotactic phase transformation of three polymorphs has been observed in variable temperature Single Crystal X-ray Diffraction experiment. The reversible phase transformation of bulk material has been confirmed by Powder X-ray diffraction study.

  6. Relation between constructs of BisBas questionnaire and some personality constructs

    OpenAIRE

    Nataša Sedlar; Simona Medved; Anja Pernek

    2008-01-01

    The goal of this study was to examine relation between constructs relevant for Gray's neuropsychological model of motivation. According to Gray's theory, two general motivational systems underlie behavior and affect: a behavioral inhibition system (BIS) and a behavioral activation system (BAS). BIS is sensitive to aversive stimuli, causes avoidance behaviors and is responsible for individual differences in anxiety. BAS is responsive to appetitive stimuli, triggers approach behavior an...

  7. Di-tert-butyl N-[2,6-bis(methoxymethoxyphenyl]iminodiacetate

    Directory of Open Access Journals (Sweden)

    Ben Capuano

    2009-04-01

    Full Text Available The title molecule, C20H31NO8, has pseudo-C2 symmetry about the C—N bond, with the bis(tert-butoxycarbonylamino group twisted from the benzene ring plane by ca 60° and the bulky tert-butoxycarbonyl (Boc groups are orientated away from the substituted aniline group. As part of an antibacterial drug discovery programme furnishing analogues of platensimycin, we unexpectedly synthesized the bis-Boc-protected aniline.

  8. Electric field-induced hole injection-enhanced photoluminescence in a N,N'-bis(3-methylphenyl)-N,N'-bis(phenyl)-benzidine-based emitter

    International Nuclear Information System (INIS)

    Xu-Xie Hui-Na; Li Wen-Bin; Peng Huan; He Yun; Yu Hao-Miao; Hou Xiao-Yuan

    2014-01-01

    Non-monotonic, asymmetrical electric field dependence of photoluminescence (PL) intensity is observed in a monolayer sample of tris-(8-hydroxyquinoline) aluminum (AlQ) doped N,N'-bis(3-methylphenyl)-N,N'-bis(phenyl)-benzidine (TPD). A possible model is proposed: the charge separation from the dissociated photoexcited excitons causes energy band bending in the organic films and improves the hole injection from the electrode, which brings about the extra fluorescence. This mechanism is further verified by a series of experiments using a series of samples, variously featuring symmetrical electrodes, block layers, and hosts with lower hole mobilities. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  9. Bis[bis(N,N-diethyl-1,1-diselenocarbamato)copper(II)], [Cu(Se(2)CNEt(2))(2)](2).

    Science.gov (United States)

    Cao, Rong; Bao, Mutai; Weng, Jiabao; Su, Weiping; Hong, Maochun

    2000-05-15

    The title centrosymmetric Cu(II) binuclear complex, bis(micro-N,N-diethyl-1,1-diselenocarbamato-Se,Se':Se)bis[(N,N-diethyl-1,1-diselenocarbamato-Se,Se')copper(II)], [Cu(Se(2)CNEt(2))(2)](2) or [Cu(2)(C(5)H(10)NSe(2))(4)], is built from two symmetry-related [Cu{Se(2)CN(Et)(2)}(2)] units by pairs of Cu-Se bonds. The coordination geometry at the unique Cu atom is distorted square pyramidal, with Cu-Se distances in the range 2.4091 (11)-2.9095 (10) A.

  10. Polyamine deprivation-induced enhanced uptake of methylglyoxal bis(guanylhydrazone) by tumor cells.

    Science.gov (United States)

    Seppänen, P; Alhonen-Hongisto, L; Jänne, J

    1981-05-05

    1. Putrescine and spermidine depletion produced by alpha-difluoromethylornithine, an irreversible inhibitor or ornithine decarboxylase (EC 4.1.1.17), resulted in a strikingly enhanced cellular uptake of methylglyoxal bis(guanylhydrazone) in cultured Ehrlich ascites carcinoma cells and human lymphocytic leukemia cells. 2. A prior priming of the cells with difluoromethylornithine followed by a short exposure of the cells to methylglyoxal bis(guanylhydrazone) rapidly established intracellular concentrations of the latter drug approaching 10 mM. 3. The enhanced transport of methylglyoxal bis(guanylhydrazone) into the tumor cells apparently required metabolic energy as the uptake of extracellular drug rapidly ceased and intracellular methylglyoxal bis(guanylhydrazone) was excreted into the medium when the glycolysis of the tumor cells was inhibited by iodoacetate. 4. A sequential treatment of cultured tumor cells with difluoromethylornithine until established polyamine depletion followed by an addition of low concentrations of methylglyoxal bis(guanylhydrazone) produced an antiproliferative action not achieved with either of the drugs alone. 5. A similar treatment schedule, i.e a priming of mice inoculated with Ehrlich ascites cells with difluoromethylornithine for a few days, likewise enhanced the uptake of methylglyoxal bis(guanylhydrazone) by the carcinoma cells, but only marginally increased the drug concentration in the liver and small intestine of the animals.

  11. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents

    International Nuclear Information System (INIS)

    Luo, Jialie; Li, Wenming; Liu, Yuwei; Zhang, Wei; Fu, Hongjun; Lee, Nelson T.K.; Yu, Hua; Pang, Yuanping; Huang, Pingbo; Xia, Jun; Li, Zhi-Wang; Li, Chaoying; Han, Yifan

    2007-01-01

    Bis(7)-tacrine has been shown to prevent glutamate-induced neuronal apoptosis by blocking NMDA receptors. However, the characteristics of the inhibition have not been fully elucidated. In this study, we further characterize the features of bis(7)-tacrine inhibition of NMDA-activated current in cultured rat hippocampal neurons. The results show that with the increase of extracellular pH, the inhibitory effect decreases dramatically. At pH 8.0, the concentration-response curve of bis(7)-tacrine is shifted rightwards with the IC 50 value increased from 0.19 ± 0.03 μM to 0.41 ± 0.04 μM. In addition, bis(7)-tacrine shifts the proton inhibition curve rightwards. Furthermore, the inhibitory effect of bis(7)-tacrine is not altered by the presence of the NMDA receptor proton sensor shield spermidine. These results indicate that bis(7)-tacrine inhibits NMDA-activated current in a pH-dependent manner by sensitizing NMDA receptors to proton inhibition, rendering it potentially beneficial therapeutic effects under acidic conditions associated with stroke and ischemia

  12. Normative data of the Barratt Impulsiveness Scale 11 (BIS-11 for Brazilian adults

    Directory of Open Access Journals (Sweden)

    Leandro F. Malloy-Diniz

    2015-09-01

    Full Text Available Objective:The Barratt Impulsiveness Scale (BIS-11 is a valid and reliable instrument, and one of the most often used tools to assess impulsivity. This study assesses the performance of a large sample of adults by using a version of BIS-11 adapted to Brazilian Portuguese.Methods:We assessed 3,053 adults from eight Brazilian states. Internal consistencies and performance data were presented for two correction criteria of BIS-11: original and the two-factor score.Results:The associations between age, sex, region, and education and the BIS-11 scores present very small effect sizes. Therefore, we provided a percentile rank parameter for the different BIS-11 subscores considering the whole sample. Given the internal consistency of the two correction systems, we found that only the two-factor system fulfills the psychometric criteria of Cronbach’s alpha (cutoff value of at least 0.6.Conclusion:Our results support the use of the Brazilian adaptation of BIS-11 in different regions of the country as a measure of impulsivity. Since high impulsiveness is a characteristic of several dysfunctional behaviors, the establishment of normative parameters is of utmost relevance and should be extended to other age ranges and populations in future studies.

  13. Reconsidering Emil Kaufmann’s Von Ledoux bis Le Corbusier

    Directory of Open Access Journals (Sweden)

    Macarena de la Vega

    2014-11-01

    Full Text Available Resumen El objetivo de este ensayo es re-abrir y re-leer Von Ledoux bis Le Corbusier de Emil Kaufmann. A pesar de que Panayotis Tournikiotis y Anthony Vidler lo incluyeran en sus respectivos discursos sobre la historiografía de la arquitectura moderna, se  propone reconsiderar a su autor como un historiador pionero de la Ilustración. Tres ideas: el único protagonista del libro es Claude-Nicolas Ledoux; la arquitectura en torno a 1800 necesitaba una reevaluación; y la obra de Kaufmann se  enmarca en un tiempo de búsqueda de una nueva ciencia del arte y una nueva historia de la arquitectura. Kaufmann es una figura de transición entre una generación previa de historiadores del arte que establecieron conceptos y principios fundamentales, y otros de su misma generación que se  embarcaron en la tarea de considerar la arquitectura moderna como objeto de una investigación histórica. Abstract The aim of this essay is to re-open and re-read the content of Emil Kaufmann’s Von Ledoux bis Le Corbusier. Even though Panayotis Tournikiotis and Anthony Vidler included it in their discussions of the historiography of modern architecture, this investigation recommends a needed reconsideration of Emil  Kaufmann as a pioneer historian of the Age of Reason. Three ideas can be highlighted: first, Claude-Nicolas Ledoux is the main character of Kaufmann’s discourse; second, the architecture around 1800 needed a reevaluation; and third, his  work takes place in a time of searching for a new science of art and for a new history of architecture. To sum up, it can be  concluded that Kaufmann is a transitional figure between a previous generation of art historians who established   fundamental concepts and principles; and others of his own generation who embarked on the hard task of considering modern architecture as a subject of historical research.

  14. Quando o índice bispectral (BIS pode fornecer valores espúrios Cuando el índice bispectral (BIS puede suministrar valores falsos When the bispectral index (Bis can give false results

    Directory of Open Access Journals (Sweden)

    Leonardo Teixeira Domingues Duarte

    2009-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O índice bispectral (BIS é um parâmetro multifatorial derivado do eletroencefalograma (EEG que permite a monitorização do componente hipnótico da anestesia. Foi obtido a partir de algoritmo derivado da análise de grande número de EEGs de voluntários e pacientes submetidos a sedações e anestesia geral com diferentes agentes anestésicos. Além de outros benefícios, o uso do BIS para monitorização da profundidade da anestesia reduz a ocorrência de despertar e memória intra-operatória. Esta revisão teve o objetivo de apresentar situações clínicas em que o BIS aponta valores espúrios, falsamente elevados ou reduzidos, em decorrência de condições do paciente ou ações de anestésicos não-previstos quando da elaboração do seu algoritmo. CONTEÚDO: Os valores do BIS podem sofrer alteração e influência em variadas situações clínicas em que há padrões anormais do EEG; efeito de diferentes anestésicos e outros fármacos não-incluídos na elaboração de seu algoritmo; interferência de equipamentos elétricos; bem como decorrentes de peculiaridades do monitor. CONCLUSÃO: Apesar de o algoritmo do BIS ter sofrido diversas alterações desde a sua primeira versão, essas situações que determinam variações espúrias dos valores do BIS devem ser reconhecidas pelo anestesiologista a fim de evitar complicações, sejam conseqüentes à sobredose anestésica, sejam por subdoses que poderão causar despertar e memória intra-operatória.JUSTIFICATIVA Y OBJETIVOS: El índice bispectral (BIS es un parámetro multifactorial derivado del electroencefalograma (EEG, que permite la monitorización del componente hipnótico de la anestesia. Fue obtenido a partir de algoritmo derivado del análisis de un gran número de EEG de voluntarios y pacientes sometidos a sedaciones y anestesia general con diferentes agentes anestésicos. Además de otros beneficios, el uso del BIS para la monitorización de la

  15. Unusual aggregation of bis(2-quinuclidinium-butyrate) hydrobromides

    Science.gov (United States)

    Dega-Szafran, Z.; Katrusiak, A.; Szafran, M.

    2010-12-01

    The molecular structure of di-[bis(2-quinuclidinium-butyrate) hydrobromide], [(QNBu) 2HBr] 2 ( 1), has been characterized by single-crystal X-ray diffraction, infrared spectroscopy and DFT calculations. The crystals ( 1) are monoclinic, space group P2 1/c with [(QNBu) 2HBr] 2 symmetry-independent units. The complex 1 consists of two independent homoconjugated cations, in which two ( S) QNBu semications, and ( S) and ( R) QNBu semications are joined by short, symmetrical O⋯H⋯O hydrogen bonds of 2.418(12) and 2.411(13) Å, respectively. The bromide anions interact electrostatically with the one positively charged nitrogen atom of each cation. The presence of short OHO hydrogen bonds is confirmed by the broad absorption in the 1500-400 cm -1 region, with the center of gravity, νH, at ca. 900 cm -1, in the solid-state FTIR spectrum. In the structure of [(QNBu) 2HBr] 2 ( 2) optimized at the B3LYP/6-31G(d,p) level of theory, the 2-quinuclidinium-butyrate units are non-equivalent. In each homoconjugated cation the 2-quinuclidinium-butyric acid interacts with the QNBu inner salt by the short, asymmetric O-H···O hydrogen bonds of 2.440 and 2.446 Å, respectively. Each bromide anion interacts electrostatically with the positively charged nitrogen atoms from both homoconjugated cations, which fold into a globular supramolecular aggregate.

  16. Contemporary carbon content of bis (2-ethylhexyl) phthalate in butter.

    Science.gov (United States)

    Tong, T; Ondov, J M; Buchholz, B A; VanDerveer, M C

    2016-01-01

    The fraction of naturally produced bis (2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer known to contaminate packaged foods, was determined for each of five 1.10 kg samples of unsalted market butter by accelerator mass spectrometry (AMS). After extraction and concentration enrichment with liquid-liquid extraction, flash column chromatography, and preparative-scale high performance liquid chromatography, each sample provided ≈ 250 μg extracts of DEHP with carbon purity ranging from 92.5 ± 1.2% (n = 3, 1σ) to 97.1 ± 0.8% (n = 3, 1σ) as measured with gas chromatography mass spectrometry (GC-MS). After corrections for method blank DEHP, co-eluting compounds, and unidentified carbon, the mean fraction of naturally produced DEHP in butter was determined to be 0.16 ± 0.12 (n = 5, 1σ). To our knowledge, this is the first report of the contemporary fraction of DEHP isolated from market butter in the U.S. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Synthesis, structurale elucidation and antioxidant study of Ortho-substituted N,N’-bis(benzamidothiocarbonyl)hydrazine derivatives

    Science.gov (United States)

    Firdausiah, Syadza; Hasbullah, S. A.; Yamin, B. M.

    2018-03-01

    Some bis(thiourea) compounds have been reported to posses excellent performance in pharmaceutical and environmental fields because of their ability to form chelating complexes with various anions and metal ions. Structurally for carbonyl thiourea derivatives, to become a chelating agent, it must adopt cis-configuration. In the present study, four new bis(thiourea) derivatives namely N,N’-bis(o-fluorobenzamidothiocarbonyl)hydrazine (1), N,N’- bis(o-chloro-benzamidothiocarbonyl)hydrazine (2), N,N’-bis(o-nitrobenzamidothiocarbonyl)-hydrazine (3), and N,N’-bis(o-methylbenzamidothiocarbonyl)hydrazine (4) were successfully synthesized and characterized by CHNS microelemental analysis, FTIR, UV-Vis, and 1H and 13C NMR spectroscopy. However chemical crystallography study showed that both thiourea moieties in compound (2) and (3) adopt trans geometry. Therefore they are potential monodentate ligand with two active moieties. DPPH radical scavenging experiment showed that compound (1), (2), and (4) exhibited higher antioxidant activity than ascorbic acid (Vitamin C).

  18. Synthesis of novel bis(perfluorophenyl azides) coupling agents: Evaluation of their performance by crosslinking of poly(ethylene oxide)

    KAUST Repository

    Mehenni, Hakim

    2011-11-01

    Novel bis(perfluorophenyl azides) coupling agents, containing spacer arms from ethylene or ethylene glycol subunits, were successfully synthesized. Nitrenes photogenerated from these novel bis(PFPA) coupling agents were applied successfully to the cross-linking of poly(ethylene oxide) (PEO10,000) in either aqueous medium or at the solid state, thus, we demonstrated the potential of these bis(PFPA) molecules as promising coupling agents in surface engineering. © 2011 Elsevier Ltd. All rights reserved.

  19. A Novel Bis(phosphido)pyridine [PNP] 2− Pincer Ligand and Its Potassium and Bis(dimethylamido)zirconium(IV) Complexes

    KAUST Repository

    Winston, Matthew S.

    2010-12-13

    A novel PNP bis(secondary phosphine)pyridine pincer ligand, 2,6-bis(2-(phenylphosphino)phenyl)pyridine, has been prepared in high yield, and the properties of the doubly deprotonated form as a ligand in K 4(PNP)2(THF)6 and (PNP)Zr(NMe2) 2 have been investigated. The neutral PNP ligand has been isolated as a mixture of noninterconverting diastereomers, due to the presence of two chirogenic phosphorus atoms of the secondary phopshines, but coordination of the dianionic form to potassium and zirconium allows for isolation of a single diastereomer in near-quantitative yield. The structure of a bis(dimethylamido) zirconium(IV) derivative of the bis(phosphido)pyridine ligand and DFT calculations suggest that the phosphides do not π-bond to early transition metals, likely due to geometric strain and possibly orbital size mismatch between phosphorus and zirconium. As a result, the soft phosphides are prone to formation of insoluble oligomers with substantial bridging of the phosphido lone pairs to other zirconium centers. © 2010 American Chemical Society.

  20. Analysis of two alternative organophosphorus flame retardants in electronic and plastic consumer products: resorcinol bis-(diphenylphosphate) (PBDPP) and bisphenol A bis (diphenylphosphate) (BPA-BDPP)

    NARCIS (Netherlands)

    Ballesteros Gomez, A.M.; Brandsma, S.H.; de Boer, J.; Leonards, P.E.G.

    2014-01-01

    Following the phase-out of polybrominated diphenyl ethers (PBDEs), organophosphorus flame retardants (PFRs) are increasingly used as alternative flame retardants in many products. Data on the presence of two alternative PFRs in consumer products, resorcinol bis (diphenylphosphate) (PBDPP or RDP) and

  1. Effect of incorporating BisGMA resin on the bonding properties of silane and zirconia primers.

    Science.gov (United States)

    Chen, Liang; Shen, Hong; Suh, Byoung In

    2013-11-01

    Some silane primers and some zirconia primers contain extra resins such as bisphenol A glycol dimethacrylate (BisGMA) in their formulations for better wetting. No studies exist on the bonding properties of zirconia and silane primers, which contain extra resins. The purpose of this study was to investigate the effect of incorporating BisGMA resin on the bonding properties of silane and zirconia primers. Silica-base lithium disilicate was etched and treated with BisGMA-incorporated Porcelain Primer, unmodified Porcelain Primer, or resin-containing Kerr Silane. Zirconia ceramic was airborne-particle abraded and treated with BisGMA-incorporated Monobond Plus, unmodified Monobond Plus, or BisGMA-containing ZPrime Plus. After primer treatment and cleaning with ethanol, the contact angles were measured to determine surface change (n=10). Shear bond strength tests were also performed to measure the adhesion strength between resin cements and ceramic surfaces (n=10). Data were statistically analyzed by 1-way ANOVA followed by the Tukey multiple comparison as a post hoc test (significance level .05). The incorporation of BisGMA resin did not significantly influence the bond strength or contact angle of the zirconia primer (P>.05), but it did significantly reduce those of the silane primer (PSilane (22 degrees, 23 MPa) had a similar contact angle and higher bond strength than the control (21 degrees, 18 MPa), but lower than Porcelain Primer (88 degrees, 34 MPa). Resin-containing ZPrime Plus (75 degrees, 29 MPa) had a similar contact angle and higher bond strength than both Monobond Plus (74 degrees, 18 MPa) and the control (15 degrees, 4 MPa). The addition of BisGMA resin significantly inhibited the efficacy of silane-containing porcelain primers but did not affect that of phosphate-containing zirconia primers. Copyright © 2013 Editorial Council for the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.

  2. Crystal structure of bis[1,3-bis(2,6-diisopropylphenylimidazol-2-ylidene]silver(I chloride tetrahydrofuran monosolvate

    Directory of Open Access Journals (Sweden)

    Inge Sänger

    2015-05-01

    Full Text Available In the title salt, [Ag(C27H36N22]Cl·C4H8O, the AgI atom is coordinated by two 1,3-bis(2,6-dimethylphenylimidazol-2-ylidene ligands. The imidazole rings are inclined to one another by 46.69 (13° and the benzene rings in each ligand are almost normal to the imdazole ring to which they are attached, with dihedral angles varying from 82.39 (13 to 88.27 (12°. There are C—H...π interactions present in the cation, involving the two ligands, and the solvent molecule is linked to the cation via a C—H...O hydrogen bond. In the crystal, molecules are linked by trifurcated C—H...(Cl,Cl,Cl hydrogen bonds, forming slabs parallel to (101. One isopropyl group is disordered over two sets of sites with an occupancy ratio of 0.447 (17:0.553 (17 and the THF molecule is disordered over two positions with an occupancy ratio of 0.589 (6:0.411 (6.

  3. μ-Oxalato-bis[(2,2′-bipyridylcopper(II] bis(perchlorate dimethylformamide disolvate monohydrate

    Directory of Open Access Journals (Sweden)

    Alexander N. Boyko

    2010-09-01

    Full Text Available The title compound, [Cu2(C2O4(C10H8N24](ClO42·2C3H7NO·H2O, contains doubly charged centrosymmetric dinuclear oxalato-bridged copper(II complex cations, perchlorate anions, and DMF and water solvate molecules. In the complex cation, the oxalate ligand is coordinated in a bis-bidentate bridging mode to the Cu atoms. Each Cu atom has a distorted tetragonal-bipyramidal environment, being coordinated by two N atoms of the two chelating bipy ligands and two O atoms of the doubly deprotonated oxalate anion. Pairs of perchlorate anions and water molecules are linked into rectangles by O—H...O bonds in which the perchlorate O atoms act as acceptors and the water molecules as donors. Methyl groups of the DMF solvent molecule are disordered over two sites with occupancies of 0.453 (7:0.547 (7, and the water molecule is half-occupied.

  4. Are concomitant patch test reactions to epoxy resin and BIS-GMA indicative of cross-reactivity?

    Science.gov (United States)

    Geier, Johannes; Lessmann, Holger; Uter, Wolfgang; Schnuch, Axel

    2007-12-01

    Despite rare simultaneous exposure, concomitant sensitisation to bisphenol A diglycidyl methacrylate (BIS-GMA) and epoxy resin frequently occurs. Immunological cross-reactivity has not been proven by animal experiments so far. Our objective was to examine cross-reactivity epidemiologically by analysing data of the Information Network of Departments of Dermatology (IVDK). From 2001 to 2005, 3,777 patients were patch tested with epoxy resin and BIS-GMA in the IVDK. We retrospectively analysed concomitant reactions to these allergens and to BIS-GMA and selected methacrylates. Additionally, we compared clinical characteristics of patients reacting to both, epoxy resin and BIS-GMA, with those of patients reacting to epoxy resin or BIS-GMA only. 185 patients reacted to epoxy resin, and 40 to BIS-GMA. Of the latter, 34 reacted to epoxy resin. There was no difference concerning exposure between the above-mentioned groups of patients. Concomitant reactions to BIS-GMA and methacrylates hardly ever occurred. Considering the fact that very few patients had been potentially exposed to BIS-GMA and that 85% of those reacting to BIS-GMA also reacted to epoxy resin, we conclude that our data are presumably indicative of immunological cross-reactivity. A verification of this hypothesis by animal experiments would be promising.

  5. Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species

    Science.gov (United States)

    Tretyakova, Natalia Y.

    2014-01-01

    Human carcinogen 1,3-butadiene (BD) undergoes metabolic activation to 3,4-epoxy-1-butene (EB), hydroxymethylvinyl ketone (HMVK), 3,4-epoxy-1,2-butanediol (EBD) and 1,2,3,4-diepoxybutane (DEB). Among these, DEB is by far the most genotoxic metabolite and is considered the ultimate carcinogenic species of BD. We have shown previously that BD-exposed laboratory mice form 8- to 10-fold more DEB–DNA adducts than rats exposed at the same conditions, which may be responsible for the enhanced sensitivity of mice to BD-mediated cancer. In the present study, we have identified 1,4-bis-(N-acetyl-l-cystein-S-yl)butane-2,3-diol (bis-BDMA) as a novel DEB-specific urinary biomarker. Isotope dilution high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was employed to quantify bis-BDMA and three other BD-mercapturic acids, 2-(N-acetyl-l-cystein-S-yl)-1-hydroxybut-3-ene/1-(N-acetyl-l-cystein-S-yl)-2-hydroxy-but-3-ene (MHBMA, from EB), 4-(N-acetyl-l-cystein-S-yl)-1,2-dihydroxybutane (DHBMA, from HMVK) and 4-(N-acetyl-l-cystein-S-yl)-1,2,3-trihydroxybutane (THBMA, from EBD), in urine of confirmed smokers, occupationally exposed workers and BD-exposed laboratory rats. Bis-BDMA was formed in a dose-dependent manner in urine of rats exposed to 0–200 p.p.m. BD by inhalation, although it was a minor metabolite (1%) as compared with DHBMA (47%) and THBMA (37%). In humans, DHBMA was the most abundant BD-mercapturic acid excreted (93%), followed by THBMA (5%) and MHBMA (2%), whereas no bis-BDMA was detected. These results reveal significant differences in metabolism of BD between rats and humans. PMID:24531806

  6. Effect of hydrostatic pressures on the superconductivity of new BiS2 based REO0.5F0.5BiS2 (RE=La, Pr and Nd) superconductors

    Science.gov (United States)

    Jha, Rajveer; Kishan, H.; Awana, V. P. S.

    2015-09-01

    We study the effect of hydrostatic pressure on superconductivity of new BiS2 based layered REO0.5F0.5BiS2 (RE=La, Pr, and Nd) compounds through the measurements of dc electrical resistivity. The REO0.5F0.5BiS2 (RE=La, Pr and Nd) compounds synthesized by solid state reaction route via vacuum encapsulation are crystallized in the tetragonal P4/nmm space group. At ambient pressure the superconducting transition onset temperatures (Tc onset) are 2.7 K, 3.5 K and 4.5 K, which are enhanced substantially under external hydrostatic pressure to 10.5 K, 7.8 K and 7.5 K for LaO0.5F0.5BiS2, PrO0.5F0.5BiS2 and NdO0.5F0.5BiS2 respectively at 1.68 GPa. The normal state electrical resistivity decreases with applied pressure for REO0.5F0.5BiS2 (RE=La, Pr and Nd). The electrical resistivity under magnetic field and applied pressure has been measured to estimate upper critical field Hc2(0), the values of which are 15.9 Tesla, 8.8 Tesla and 8.2 Tesla for LaO0.5F0.5BiS2, PrO0.5F0.5BiS2 and NdO0.5F0.5BiS2 compounds. Substantial enhancement of superconductivity under moderate pressures in studied new BiS2 based superconductors call for the attention of condensed matter physics community.

  7. [Bis(diphenylphosphinomethane-κ2P,P′]dichloridopalladium(II

    Directory of Open Access Journals (Sweden)

    Allen D. Hunter

    2009-02-01

    Full Text Available The title complex, [PdCl2(C25H22P2], is a slightly distorted square-planar bis(diphenylphosphinomethane cis-complex of PdCl2. The structure of a polymorph of the title compound has been described earlier, but the arrangement of the molecules observed in the current structure is distinctively different from that previously reported [Steffen & Palenik (1976. Inorg. Chem. 15, 2432–2439]. The earlier report describes a structure with individual well separated molecules crystallizing in space group P21/n. The polymorph described here, which is isostructrural to its Pt analogue [Babai et al. (2006. Z. Anorg. Allg. Chem. 632, 639–644], crystallizes in C2/c with chains of C2-symmetric molecules stretching parallel to the b axis. The Pd atoms and the bisphosphinomethane units are located on two different positions created by a non-crystallographic mirror operation with an occupancy of 0.6677 (11 for the major (PCH2PPd moiety. The positions of the Cl atoms of the minor moiety do coincide perfectly with those of the next molecule along the chain parallel to b, and they are thus not included in the disorder. The phenyl rings also do not take part in the disorder and are common to both the major and minor moieties of the (PCH2PPdCl2 units. Assuming no defects, molecules in each chain will thus have to be oriented the same way and the effect of the disorder of the (PCH2PPd unit is thus a reversal in direction of the chains parallel to b. The presence of light streaks of intensity between actual Bragg peaks indicates that a somehow ordered arrangement not resolved in the Bragg diffraction data may be present (i.e. an incommensurate superstructure rather than a random or domain arrangement of the chains.

  8. New Ir Bis-Carbonyl Precursor for Water Oxidation Catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Daria L. [Department of Chemistry, Yale University, 225; Beltrán-Suito, Rodrigo [Department of Chemistry, Yale University, 225; Thomsen, Julianne M. [Department of Chemistry, Yale University, 225; Hashmi, Sara M. [Department of Chemical and Environmental; Materna, Kelly L. [Department of Chemistry, Yale University, 225; Sheehan, Stafford W. [Catalytic Innovations LLC, 70 Crandall; Mercado, Brandon Q. [Department of Chemistry, Yale University, 225; Brudvig, Gary W. [Department of Chemistry, Yale University, 225; Crabtree, Robert H. [Department of Chemistry, Yale University, 225

    2016-02-05

    This paper introduces IrI(CO)2(pyalc) (pyalc = (2-pyridyl)-2-propanoate) as an atom-efficient precursor for Ir-based homogeneous oxidation catalysis. This compound was chosen to simplify analysis of the water oxidation catalyst species formed by the previously reported Cp*IrIII(pyalc)OH water oxidation precatalyst. Here, we present a comparative study on the chemical and catalytic properties of these two precursors. Previous studies show that oxidative activation of Cp*Ir-based precursors with NaIO4 results in formation of a blue IrIV species. This activation is concomitant with the loss of the placeholder Cp* ligand which oxidatively degrades to form acetic acid, iodate, and other obligatory byproducts. The activation process requires substantial amounts of primary oxidant, and the degradation products complicate analysis of the resulting IrIV species. The species formed from oxidation of the Ir(CO)2(pyalc) precursor, on the other hand, lacks these degradation products (the CO ligands are easily lost upon oxidation) which allows for more detailed examination of the resulting Ir(pyalc) active species both catalytically and spectroscopically, although complete structural analysis is still elusive. Once Ir(CO)2(pyalc) is activated, the system requires acetic acid or acetate to prevent the formation of nanoparticles. Investigation of the activated bis-carbonyl complex also suggests several Ir(pyalc) isomers may exist in solution. By 1H NMR, activated Ir(CO)2(pyalc) has fewer isomers than activated Cp*Ir complexes, allowing for advanced characterization. Future research in this direction is expected to contribute to a better structural understanding of the active species. A diol crystallization agent was needed for the structure determination of 3.

  9. Monitoring sleep depth: analysis of bispectral index (BIS) based on polysomnographic recordings and sleep deprivation.

    Science.gov (United States)

    Giménez, Sandra; Romero, Sergio; Alonso, Joan Francesc; Mañanas, Miguel Ángel; Pujol, Anna; Baxarias, Pilar; Antonijoan, Rosa Maria

    2017-02-01

    The assessment and management of sleep are increasingly recommended in the clinical practice. Polysomnography (PSG) is considered the gold standard test to monitor sleep objectively, but some practical and technical constraints exist due to environmental and patient considerations. Bispectral index (BIS) monitoring is commonly used in clinical practice for guiding anesthetic administration and provides an index based on relationships between EEG components. Due to similarities in EEG synchronization between anesthesia and sleep, several studies have assessed BIS as a sleep monitor with contradictory results. The aim of this study was to evaluate objectively both the feasibility and reliability of BIS for sleep monitoring through a robust methodology, which included full PSG recordings at a baseline situation and after 40 h of sleep deprivation. Results confirmed that the BIS index was highly correlated with the hypnogram (0.89 ± 0.02), showing a progressive decrease as sleep deepened, and an increase during REM sleep (awake: 91.77 ± 8.42; stage N1: 83.95 ± 11.05; stage N2: 71.71 ± 11.99; stage N3: 42.41 ± 9.14; REM: 80.11 ± 8.73). Mean and median BIS values were lower in the post-deprivation night than in the baseline night, showing statistical differences for the slow wave sleep (baseline: 42.41 ± 9.14 vs. post-deprivation: 39.49 ± 10.27; p = 0.02). BIS scores were able to discriminate properly between deep (N3) and light (N1, N2) sleep. BIS values during REM overlapped those of other sleep stages, although EMG activity provided by the BIS monitor could help to identify REM sleep if needed. In conclusion, BIS monitors could provide a useful measure of sleep depth in especially particular situations such as intensive care units, and they could be used as an alternative for sleep monitoring in order to reduce PSG-derived costs and to increase capacity in ambulatory care.

  10. Interaction and Binding Modes of bis-Ruthenium(II Complex to Synthetic DNAs

    Directory of Open Access Journals (Sweden)

    Hasi Rani Barai

    2016-06-01

    Full Text Available [μ-(linkerL2(dipyrido[3,2-a:2′,3′-c]phenazine2(phenanthroline2Ru(II2]2+ with linker: 1,3-bis-(4-pyridyl-propane, L: PF6 (bis-Ru-bpp was synthesized and their binding properties to a various polynucleotides were investigated by spectroscopy, including normal absorption, circular dichroism(CD, linear dichroism(LD, and luminescence techniques in this study. On binding to polynucleotides, the bis-Ru-bpp complex with poly[d(A-T2], and poly[d(I-C2] exhibited a negative LDr signal whose intensity was as large as that in the DNA absorption region, followed by a complicated LDr signal in the metal-to-ligand charge transfer region. Also, the emission intensity and equilibrium constant of the bis-Ru-bpp complex with poly[d(A-T2], and poly[d(I-C2] were enhanced. It was reported that both of dppz ligand of the bis-Ru-bpp complex intercalated between DNA base-pairs when bound to native, mixed sequence DNA. Observed spectral properties resemble to those observed for poly[d(A-T2] and poly[d(I-C2], led us to be concluded that both dppz ligands intercalate between alternated AT and IC bases-pairs In contrast when bis-Ru-bpp complex was bound to poly[d(G-C2], the magnitude of the LDr in the dppz absorption region, as well as the emission intensity, was half in comparison to that of bound to poly[d(A-T2], and poly[d(I-C2]. Therefore the spectral properties of the bis-Ru-bpp-poly[d(G-C2] complex suggested deviation from bis-intercalation model in the poly[d(G-C2] case. These results can be explained by a model whereby one of the dppz ligands is intercalated while the other is exposed to solvent or may exist near to phosphate. Also it is indicative that the amine group of guanine in the minor groove provides the steric hindrance for incoming intercalation binder and it also takes an important role in a difference in binding of bis-Ru-bpp bound to poly[d(A-T2] and poly[d(I-C2].

  11. Isolation and Characterization of 1,3-Bis(vinylbenzylthymine: Copolymerization with Vinylbenzyl Thymine Ammonium Chloride

    Directory of Open Access Journals (Sweden)

    Ngoc Chau H. Vy

    2017-01-01

    Full Text Available A novel bioinspired molecule, 1,3-bis(vinylbenzylthymine (bisVBT, was isolated as a by-product during the synthesis of 1-(4-vinylbenzylthymine (VBT and analyzed with various techniques: NMR, IR, and Single-Crystal X-ray Diffraction. In addition to embodying all the desired characteristics of VBT (i.e., having the ability to undergo a 2π+2π photodimerization reaction upon UV irradiation, a derivatization site, hydrogen bonding sites, and aromatic stacking ability the bisVBT monomer has the added benefit of having two vinyl groups for cross-polymerization. Copolymerizing the bisVBT monomer with the charged monomer vinylbenzyl triethylammonium (VBA chloride, different copolymers/terpolymers/cross-linked network were obtained, as it was shown by the absence of the vinyl resonance in the NMR spectra. Thermal Gravimetric Analysis (TGA and Differential Scanning Calorimetry (DSC showed an indication of materials with low degree of cross-linking. A Gel Permeation Chromatography (GPC method was improved to better characterize the molecular weight distributions of the cationic structures. Preliminary qualitative cross-linking studies were performed on bisVBT-VBA copolymers, and a comparison with VBT-VBA copolymers is presented.

  12. Alexandre Lamfalussy and the origins of the BIS macro-prudential approach to financial stability

    Directory of Open Access Journals (Sweden)

    Ivo Maes

    2010-01-01

    Full Text Available Among the international policy institutions, the Bank for International Settlements (BIS is known for its sensitivity to financial stability issues. Typical for the BIS is a Òmacro-prudentialÓ approach. In this paper, it is argued that Alexandre Lamfalussy, who was at the BIS from 1976 to 1993, played a crucial role in shaping the BIS approach. Typical for Lamfalussy are a broad macroeconomic view and a focus on the systemically important institutions. In LamfalussyÕs view, there is thus very much an overlap between the micro- and macro-prudential dimensions of financial stability. The main reasons for his sensitivity to financial fragility were: a ÒKeynesianÓ Weltanschauung (that a market economy is not sufficiently self-correcting, the emphasis of Dupriez (his teacher on cycles, LamfalussyÕs experience as a commercial banker, BIS involvement in financial stability issues, especially the Latin American debt crisis of 1982-83 and research on financial innovations.

  13. BIS2Analyzer: a server for co-evolution analysis of conserved protein families.

    Science.gov (United States)

    Oteri, Francesco; Nadalin, Francesca; Champeimont, Raphaël; Carbone, Alessandra

    2017-07-03

    Along protein sequences, co-evolution analysis identifies residue pairs demonstrating either a specific co-adaptation, where changes in one of the residues are compensated by changes in the other during evolution or a less specific external force that affects the evolutionary rates of both residues in a similar magnitude. In both cases, independently of the underlying cause, co-evolutionary signatures within or between proteins serve as markers of physical interactions and/or functional relationships. Depending on the type of protein under study, the set of available homologous sequences may greatly differ in size and amino acid variability. BIS2Analyzer, openly accessible at http://www.lcqb.upmc.fr/BIS2Analyzer/, is a web server providing the online analysis of co-evolving amino-acid pairs in protein alignments, especially designed for vertebrate and viral protein families, which typically display a small number of highly similar sequences. It is based on BIS2, a re-implemented fast version of the co-evolution analysis tool Blocks in Sequences (BIS). BIS2Analyzer provides a rich and interactive graphical interface to ease biological interpretation of the results. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. Development of dental resin luting agents based on Bis-EMA4: bond strength evaluation

    Directory of Open Access Journals (Sweden)

    2008-02-01

    Full Text Available The aim of this study was to investigate the influence of incorporating Bis-EMA4 monomer into experimental Bis-GMA/TEGDMA-based resin luting agents on the bond strength to dentin. Seven mixtures were prepared with the following ratios (wt% of Bis-GMA/TEGDMA/Bis-EMA4: 50/50/0, 50/30/20, 50/10/40, 50/0/50, 30/10/60, 10/10/80 and 0/0/100. Camphorquinone (0.4 wt%, N,N-dimethyl-p-toluidine (0.8 wt% and hydroquinone (0.2 wt% were dissolved in each mixture, which was loaded with silanated strontium glass fillers to a constant content of 60 wt%. Bond strength was evaluated by microshear testing (n = 10 on bovine dentin. Data were submitted to Analysis of Variance (p<0.05. Modes of failure were classified under magnification (200×. Bond strength means (MPa, respective to each agent, were: 19.4, 19.8, 20.0, 19.1, 16.8, 18.7 and 17.8. No significant differences were detected among groups. Mixed failures were generally predominant for all materials. In conclusion, the addition of Bis-EMA4 presented no significant influence on the bond strength of the experimental resin luting agents to dentin.

  15. [Early detection of hypoxia with BIS monitoring during percutaneous cardiopulmonary support].

    Science.gov (United States)

    Okawa, H; Hirota, K; Sakai, I; Tsubo, T; Ishihara, H; Matuki, A

    2001-04-01

    We report a patient in whom hypoxia developed during percutaneous cardiopulmonary bypass (PCPS) and was detected with the lowering of the bispectral index (BIS) values. A 7-yr-old boy was managed with PCPS for the treatment of cardiogenic shock after cardiac surgery. His circulation was dependent on PCPS and pulse pressure was nearly zero. Signals by pulse oxymetry were undetectable and periodical blood gas analysis was performed to confirm proper oxygenation. BIS was monitored, and a gradual decrease in the value was observed. Careful observation also revealed darkening of the blood in the PCPS circuit and blood gas analysis showed severe hypoxia. Oxygen concentration of the gas to a PCPS oxygenator was increased immediately and new PCPS circuit was prepared. It took almost two minutes to exchange the circuit. Near circulatory arrest might have occurred during the procedure and BIS and suppression ratio (SR) became below 10 and above 90, respectively. Both returned to the previous values 30 min after the replacement of the circuit. Severe hypoxia, otherwise overlooked, was detected with BIS monitoring and BIS reflected the circulatory status of the patient, especially of the brain. This monitoring is useful to confirm proper oxygenation during PCPS.

  16. Acoplamiento molecular y actividad antibacteriana de las tioureas (R,R-N,N´-bis(1-ciclohexiletiltiourea y (R,R-N,N´-bis(1-feniletiltiourea

    Directory of Open Access Journals (Sweden)

    Fabían Martínez Flores

    2013-05-01

    Full Text Available Las tioureas, son compuestos resultantes de sustituir el átomo de oxígeno de la urea (NH2CONH2 por un átomo de azufre (NH2CSNH2. Actualmente se ha visto que las tioureas presentan diversas actividades biológicas, dentro de las que se encuentra la antimicrobiana. En el presente estudio se evaluó la actividad antibacteriana mediante acoplamiento molecular entre la enzima DNA girasa (receptor y las tioureas (R, R-N,N´-bis(1 ciclohexiletiltiourea (CYTU1 y (R,R-N,N´-bis(1-feniletiltiourea (CYTU2 como ligando en busca del posible mecanismo de acción de estos compuestos, los resultados muestran que existe interacción entre la enzima y ambas tioureas en el sitio activo. Por otro lado, también se evaluó la actividad antibacteriana frente a cepas de Sthapylococcus aureus, Escherichia coli y Pseudomonas fluorescens, mediante el método de microdilución en caldo con la adición de bromuro de 3-(4,5-dimetil-2-tiazolil-2,5-difeniltetrazolium (MTT, como parte del ensayo de viabilidad, mostrando una disminución de la misma sólo contra las bacterias gram negativas, siendo la tiourea CYTU2 la que mostró mejor actividad antibacteriana. Molecular docking and antibacterial activity thioureas (R,R-N,N´-bis(1-cyclohexyethylthiourea and (R,R-N,N´-bis(1-phenylethylthiourea Abstract Thioureas are resultant compounds of substitute the oxygen atom from urea (NH2CONH2 for a sulfur atom (NH2CSNH2. There are evidential that show the biological activity of thioureas, within which are antibacterial activity. We studied the antibacterial activity of two thioureas (R,R-N,N´-bis(1 cyclohexylethylthiourea (CYTU1 y (R,R-N,N´-bis(1 phenylethylthiourea (CYTU2 in silico using Molecular Docking between the DNA gyrase enzyme (receptor and the two thioureas (ligand. The results showed interaction between DNA girase and both thioureas on the pocket of the enzyme. By other hand, the biological activity was evaluated against the following bacterial strains: Sthapylococcus

  17. Proton transfer bis-benzazole fluors and their use in scintillator detectors

    Science.gov (United States)

    Kauffman, Joel M.

    1994-01-01

    A novel class of proton transfer, bis-benzazole, fluorescent compounds, i.e., fluors, is disclosed. The novel fluors include substituted or unsubstituted 1,4-bis(2-benzazolyl)-2-hydroxybenzenes and 1,4-bis(2-benzazolyl)-2-amidobenzenes wherein the benzazolyl group may be benzoxazolyl, benzimidazolyl, benzothiazolyl, and the like. The benzazolyl groups may be substituted with one or more alkyl groups to improve solubility in organic matrix materials such as solvents, monomers, resins, polymers, and the like. The novel fluors may be used in the manufacture of fluorescent coatings, objects, scintillators, light sources and the like. The novel fluors are particularly useful for radiation-hard, solid scintillators for the detection and measurement of high energy particles and radiation.

  18. Preparation, characterization and thermal stability of bentonite modified with bis-imidazolium salts

    Energy Technology Data Exchange (ETDEWEB)

    Makhoukhi, B., E-mail: benamarmakh@yahoo.fr [Laboratory of Separation and Purification Technologies, Department of Chemistry, Tlemcen University, Box 119, Tlemcen (Algeria); Villemin, D. [Laboratoire de Chimie Moléculaire et Thio-organique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN and Université de Caen, 14050 Caen (France); Didi, M.A. [Laboratory of Separation and Purification Technologies, Department of Chemistry, Tlemcen University, Box 119, Tlemcen (Algeria)

    2013-02-15

    Sodium bentonite was modified with several organic bis-imidazolium salts. Organoclays with water soluble surfactants were prepared by the traditional cation exchange reaction. The bis-imidazolium-bentonites were characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction analysis (PXRD) and thermogravimetric analysis (TGA). The effect of chemical composition and molecular weight of the salts on the thermal stability and basal spacing were evaluated. The bis-imidazolium-bentonites showed enhanced thermal stability (300–400 °C) and may be potentially useful materials for melt processing of polymer/layered silicates nanocomposites. - Highlights: ► Geometry and volume of the molecule influence on interlayer spacing of modified bentonites. ► The intercalation increases with molecule length. ► The modified bentonites have an appreciably higher thermal stability.

  19. Impulsivity components measured by the Brazilian version of the Barratt Impulsiveness Scale (BIS-11

    Directory of Open Access Journals (Sweden)

    Alina Gomide Vasconcelos

    2015-03-01

    Full Text Available The main purpose of this study was to investigate the psychometric properties of the Barratt Impulsiveness Scale (BIS-11. Content item analysis was conducted by seven doctoral students. A convenience sample of 897 students was submitted to BIS-11 and they also filled self-reports about Minor Mental Disorder and ADHD symptoms, alcohol use and cigarette smoking. Mean age was 27.32 (SD=8.69 years, 56% were female and 52% had incomplete college degree. Content and factorial analyses revealed that impulsivity was best represented by two latent factors labeled non-planning and inhibition behaviors. Test retest agreement tended to produce similar score patterns seven months after the first evaluation. Additionally, BIS-11 scores discriminated subjects in terms of cigarette smoking and psychopathological symptoms, which indicated evidences regarding criterion-related validity. The theoretical discussion was present based on the neuropsychological model of hot and cool aspects of executive function.

  20. Influence of body position, food and beverage consumption on BIS measurements

    Science.gov (United States)

    Medrano, G.; Eitner, F.; Ismail, A. H.; Pikkemaat, R.; Cordes, A.; Floege, J.; Leonhardt, S.

    2010-04-01

    Continuous monitoring of fluid changes using bioimpedance spectroscopy (BIS) during hemodialysis could help to predict hypotensive complications and extend the patient's life. Food and beverage consumption during the treatment may influence the measurements and the calculated fluid removal. In the present article the change observed in whole body and segmental (knee-to-knee, abdomen) BIS measurements following a sequence similar to the one of dialysis treatment (lying down, sitting and eating, lying down) on healthy subjects is presented. The measurements have been performed using a commercial bioimpedance device with a frequency range of 5 kHz to 1 MHz. Knee-to-knee measurements seem to be less sensitive to these influences, compared to the standard whole body and the alternative abdomen BIS measurements. The results indicate that the individual influence of both body posture and food and beverage consumption may be superposed when combined.

  1. BIS, BAS, and response conflict: Testing predictions of the revised reinforcement sensitivity theory.

    Science.gov (United States)

    Berkman, Elliot T; Lieberman, Matthew D; Gable, Shelly L

    2009-01-01

    Gray's (1970) reinforcement sensitivity theory (RST) was recently updated (Gray & McNaughton, 2000), but the changes have not received extensive empirical validation. The study tests three novel predictions of the revised RST. First, the behavioral activation system (BAS) is expected to be sensitive to both conditioned and unconditioned incentives. Second, the behavioral inhibition system (BIS) is expected to be sensitive to conflicting incentives such as between unconditioned and conditioned stimuli, and not to avoidance responses or aversive stimuli alone. Third, during approach-avoidance conflicts only, BAS is expected to moderate BIS responses to conflict such that individuals with high BAS show the strongest effect of BIS. In order to test these hypotheses, we developed a novel incentive task that crosses approach/avoidance conditioned responses to appetitive/aversive unconditioned stimuli. Conflict between unconditioned and conditioned stimuli occurred on the approach-aversive and avoid-appetitive trials. Results confirm the predictions and provide support for the revised RST.

  2. Two-dimensional delocalized states in organometallic bis-acetylide networks on Ag(111).

    Science.gov (United States)

    Yang, Zechao; Gebhardt, Julian; Schaub, Tobias A; Sander, Tim; Schönamsgruber, Jörg; Soni, Himadri; Görling, Andreas; Kivala, Milan; Maier, Sabine

    2018-02-22

    The electronic structure of surface-supported organometallic networks with Ag-bis-acetylide bonds that are intermediate products in the bottom-up synthesis of graphdiyne and graphdiyne-like networks were studied. Scanning tunneling microscopy (STM) and spectroscopy (STS) reveal a frontier, unoccupied electronic state that is delocalized along the entire organometallic network and proves the covalent nature of the Ag-bis-acetylide bonds. Density-functional theory (DFT) calculations corroborate the spatial distribution of the observed delocalized state and attribute it to band mixing of carbon and silver atoms combined with n-doping of the metal surface. The metal-bis-acetylide bonds are typical metal-organic bonds with mixed character containing covalent and strong ionic contributions. Moreover, the organometallic networks exhibit a characteristic graphene-like band structure with linear band dispersion at each K point.

  3. Neoleptonema yongpilii E.-Y. Lee & I.K. Lee, gen. et sp. nov. (Phaeophyceae), based on morphological characters and RuBisCO spacer sequences

    DEFF Research Database (Denmark)

    Lee, E.-Y.; Pedersen, Poul Møller; Lee, I.K.

    2002-01-01

    Elachistaceae, Neoleptonema yongpilii gen. et sp. nov., phylogenetic relationships, plurilocular sporangia, RuBisCO spacer sequences......Elachistaceae, Neoleptonema yongpilii gen. et sp. nov., phylogenetic relationships, plurilocular sporangia, RuBisCO spacer sequences...

  4. Cytotoxicity Evaluation of Two Bis-Acryl Composite Resins Using Human Gingival Fibroblasts.

    Science.gov (United States)

    Gonçalves, Fabiano Palmeira; Alves, Gutemberg; Guimarães, Vladi Oliveira; Gallito, Marco Antônio; Oliveira, Felipe; Scelza, Míriam Zaccaro

    2016-01-01

    Bis-acryl resins are used for temporary dental restorations and have shown advantages over other materials. The aim of this work was to evaluate the in vitro cytotoxicity of two bis-acryl composite resins (Protemp 4 and Luxatemp Star), obtained at 1, 7 and 40 days after mixing the resin components, using a standardized assay employing human primary cells closely related to oral tissues. Human gingival fibroblast cell cultures were exposed for 24 h to either bis-acryl composite resins, polystyrene beads (negative control) and latex (positive control) extracts obtained after incubation by the different periods, at 37 °C under 5% CO2. Cell viability was evaluated using a multiparametric procedure involving sequential assessment (using the same cells) of mitochondrial activity (XTT assay), membrane integrity (neutral red test) and total cell density (crystal violet dye exclusion test). The cells exposed to the resin extracts showed cell viability indexes exceeding 75% after 24 h. Even when cells were exposed to extracts prepared with longer conditioning times, the bis-acryl composite resins showed no significant cytotoxic effects (p>0.05), compared to the control group or in relation to the first 24 h of contact with the products. There were no differences among the results obtained for the bis-acryl composite resins evaluated 24 h, 7 days and 40 days after mixing. It may be concluded that the bis-acryl resins Protemp 4 and Luxatemp Star were cytocompatible with human gingival fibroblasts, suggesting that both materials are suitable for use in contact with human tissues.

  5. Approaches to lung cancer treatment using the CD3E x GP-2-directed bispecific monoclonal antibody BIS-1

    NARCIS (Netherlands)

    Kroesen, BJ; Nieken, J; Sleijfer, DT; Molema, G; deVries, EGE; Groen, HJM; Helfrich, W; The, TH; Mulder, NH; deLeij, L

    1997-01-01

    The bispecific monoclonal antibody (bsAb) BIS-1 combines a monoclonal-antibody(mAb)-defined specificity for the CD3 complex, as present on all T lymphocytes, with a mAb-defined specificity for the pancarcinoma/epithelium associated glycoprotein EGP-2. In vitro studies indicate that BIS-1 can direct

  6. Suppression of phytohemagglutinin-induction of thymidine uptake in guinea pig lymphocytes by methylglyoxal bis(guanylhydrazone) treatment.

    Science.gov (United States)

    Otani, S; Matsui, I; Morisawa, S

    1977-10-18

    Treatment with methylglyoxal bis(guanylhydrazone), a specific inhibitor of S-adenosylmethionine decarboxylase (EC 4.1.1.50), suppressed the phytohemagglutinin-induction of [3H]thymidine uptake by guinea pig lymphocytes. The kinetics of [3H]thymidine uptake revealed that the Km value for thymidine was not changed, but the V value was markedly lowered by the methylglyoxal bis(guanylhydrazone) treatment. The induction of ATP: thymidine 5'-phosphotransferase (EC 2.7.1.75) (thymidine kinase) activity by phytohemagglutinin was suppressed to about the same extent as the induction of thymidine uptake. These suppressions were dependent on the methylglyoxal bis(guanylhydrazone) doses and on duration of the methylglyoxal bis(guanylhydrazone) treatment. Analysis of [3H]thymidine labelled compounds of the acid-soluble fraction showed that conversion of thymidine to thymidine 5'-triphosphate was inhibited by the methylglyoxal bis(guanylhydrazone) treatment. DNA polymerase activity was less inhibited by the methylglyoxal bis(guanylhydrazone) treatment in comparison with the methylglyoxal bis(guanylhydrazone) inhibition of thymidine uptake by whole cells. These results strongly suggested that blocking of polyamine accumulation by the methylglyoxal bis(guanylhydrazone) treatment influenced phytohemagglutinin induction of thymidine phosphorylation, resulting in a decrease of thymidine incorporation into DNA.

  7. Bis(trialkylsilyl) peroxides as alkylating agents in the copper-catalyzed selective mono-N-alkylation of primary amides.

    Science.gov (United States)

    Sakamoto, Ryu; Sakurai, Shunya; Maruoka, Keiji

    2017-06-13

    The copper-catalyzed selective mono-N-alkylation of primary amides with bis(trialkylsilyl) peroxides as alkylating agents was reported. The results of a mechanistic study suggest that this reaction should proceed via a free radical process that includes the generation of alkyl radicals from bis(trialkylsilyl) peroxides.

  8. Immunomodulatory effects of intravenous bis-1 f(ab')(2) administration in renal-cell cancer-patients

    NARCIS (Netherlands)

    Janssen, R. A. J.; Kroesen, B. J.; Mesander, G.; Sleijfer, D. T.; The, T. Hauw; Mulder, N. H.; de Leij, L

    We report the immunomodulatory effects of an intravenous treatment with F(ab')(2) fragments of the bispecific monoclonal antibody BIS-1 during subcutaneous recombinant interleukin 2 (rIL-2) therapy of renal cell cancer (RCC) patients. BIS-1 is directed against both the CD3 antigen on T cells and the

  9. 21 CFR 73.3106 - 1,4-Bis[4-(2-methacryloxyethyl) phenylamino]anthraquinone copolymers.

    Science.gov (United States)

    2010-04-01

    ...]anthraquinone copolymers. 73.3106 Section 73.3106 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... § 73.3106 1,4-Bis[4-(2-methacryloxyethyl) phenylamino]anthraquinone copolymers. (a) Identity. The color additive is 1,4-bis[4-(2-methacryloxyethyl) phenylamino]anthraquinone (CAS Reg. No. 121888-69-5...

  10. Cyclization reactions of bis(allenes) for the synthesis of polycarbo(hetero)cycles.

    Science.gov (United States)

    Alcaide, Benito; Almendros, Pedro; Aragoncillo, Cristina

    2014-05-07

    The chemistry of allenes is an appealing topic which fascinates chemists nowadays. Their reactivity and versatility makes this skeleton a useful moiety to create a great variety of structures depending on the functional groups attached and the reaction conditions used. Recently, there is a growing interest in the study of the reactivity of bis(allenes) inspired in the chemistry developed in simple allenes. In this review a collection of examples of cyclization reactions of bis(allenes) is presented as well as the future perspectives.

  11. Repair of bis-acryl provisional restorations using flowable composite resin.

    Science.gov (United States)

    Bohnenkamp, David M; Garcia, Lily T

    2004-11-01

    Provisional restorations provide interim coverage for prepared teeth while fixed definitive restorations are fabricated. Several types of autopolymerizing acrylic resins have been used for many years to fabricate provisional restorations. In recent years, bis-acryl resin composite material has gained popularity among clinicians for the direct fabrication of provisional fixed restorations. Occasionally, deficiencies may occur while fabricating a direct provisional restoration and require chairside repair. This article describes an effective procedure for the use of light-polymerized flowable composite resin for the intraoral repair of bis-acryl provisional restorations.

  12. Diminished excretion of polyamines from BHK-21/C13 cells exposed to methylglyoxal bis(guanylhydrazone).

    Science.gov (United States)

    Melvin, M A; Keir, H M

    1978-01-01

    Methylglyoxal bis(guanylhydrazone) (1,1'-[methylethanediylidine)dinitrilo]diguanidine) inhibited the growth of BHK-21/C13 cells in monolayer cultures. Accumulation of spermidine and spermine was inhibited, whereas the accumulation of putrescine was increased. The intracellular spermidine/spermine molar ratio decreased conly slightly after exposure of the cells to 20 micrometer-methylglyoxal bis(guanylhydrazone) for 1 day. Cells incubated in the presence of the drug released less polyamine into the culture medium that did control cells, the polyamine released consisting almost exclusively of spermidine, both free and as a conjugated form. PMID:697761

  13. Well-Defined Silica Grafted Molybdenum Bis(imido) Catalysts for Imine Metathesis Reactions

    KAUST Repository

    Barman, Samir

    2017-04-06

    Novel site-isolated tetracoordinated molybdenum complexes possessing bis(imido) ligands, [(≡Si–O)2Mo(═NR)2] (R = t-Bu, 2,6-C6H3-i-Pr2), were immobilized on partially dehydroxylated silica (SiO2-200) by a rigorous surface organometallic chemistry protocol. The newly developed materials adorned with bis(imido) functional units, which were previously exploited mainly as spectator ligands on silica-supported olefin metathesis molybdenum catalysts, are found to be efficient heterogeneous catalytic systems for imine cross metathesis under mild conditions.

  14. The BIS and the Latin American debt crisis of the 1980s

    OpenAIRE

    Piet Clement; Ivo Maes

    2013-01-01

    The Latin American debt crisis, which broke out in August 1982, was the first global financial crisis in the postwar period. While the crisis started in the "periphery", it constituted a threat to the "core" of the world economy, as the banking system was under severe pressure. Alongside the IMF, the BIS played an important role in coordinating the international response to the crisis. Moreover, a lot of work at the BIS in the second half of the 1970s had aimed at restraining the debt build-u...

  15. Mono- and Bis(pyrrolo)tetrathiafulvalene Derivatives Tethered to C60

    DEFF Research Database (Denmark)

    Solano, Marta Vico; Della Pia, E. A.; Jevric, M.

    2014-01-01

    A series of mono- (MPTTF) and bis(pyrrolo) tetrathiafulvalene (BPTTF) derivatives tethered to one or two C-60 moieties was synthesized and characterized. The synthetic strategy for these dumbbell-shaped compounds was based on a 1,3-dipolar cycloaddition reaction between aldehyde-functionalized MP......A series of mono- (MPTTF) and bis(pyrrolo) tetrathiafulvalene (BPTTF) derivatives tethered to one or two C-60 moieties was synthesized and characterized. The synthetic strategy for these dumbbell-shaped compounds was based on a 1,3-dipolar cycloaddition reaction between aldehyde...

  16. Regiochemically Controlled Synthesis of a β-4-β' [70]Fullerene Bis-Adduct.

    Science.gov (United States)

    Cerón, Maira R; Castro, Edison; Neti, Venkata S Pavan K; Dunk, Paul W; Echegoyen, Luis A

    2017-01-20

    A β-4-β' C 70 bis-adduct regioisomer and an uncommon mono-adduct β-malonate C 70 derivative were synthesized by using a Diels-Alder cycloaddition followed by an addition-elimination of bromo-ethylmalonate and a retro-Diels-Alder cycloaddition reaction. We also report the regioselective synthesis and spectroscopic characterization of C s -symmetric tris- and C 2v -symmetric tetra-adducts of C 70 , which are the precursors of the mono- and bis-adduct final products.

  17. Psychometric Properties of Carver and White's (1994) BIS/BAS Scales in a Large Sample of Offenders.

    Science.gov (United States)

    Poythress, Norman G; Skeem, Jennifer L; Weir, John; Lilienfeld, Scott O; Douglas, Kevin S; Edens, John F; Kennealy, Patrick J

    2008-12-01

    Contemporary motivational theories of psychopathy (Lykken, 1995) employ constructs from Gray's Reinforcement Sensitivity Theory (RST; Gray, 1982), behavioral inhibition system (BIS) and behavioral activation system (BAS) functioning, to explain etiologic differences in psychopathy subtypes. Carver and White's (1994) BIS/BAS scales are the most widely used measures of these constructs, yet there is a dearth of research on how these measures perform with offenders. Using a sample of 1,515 offenders, we found evidence that five, rather than the usual four factors, underpin the BIS/BAS scales. Importantly, BIS items that tap into anxiety and fear sensitivity, respectively, split to form separate factors, yielding a structure that is more consistent with the revised (Gray & McNaughton, 2000) than with the earlier version of RST. Implications for the use of the BIS/BAS scales to study psychopathy in offenders are discussed.

  18. Investigation of Ternary Mixtures Containing 1-Ethyl-3-methylimidazolium Bis(trifluoromethanesulfonyl)azanide, Ethylene Carbonate and Lithium Bis(trifluoromethanesulfonyl)azanide

    Science.gov (United States)

    Hofmann, Andreas; Migeot, Matthias; Arens, Lukas; Hanemann, Thomas

    2016-01-01

    Temperature-dependent viscosity, conductivity and density data of ternary mixtures containing 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)azanide (EMIM-TFSA), ethylene carbonate (EC), and lithium bis(trifluoromethanesulfonyl)azanide (Li-TFSA) were determined at atmospheric pressure in the temperature range of 20 to 80 °C. Differential scanning calorimetry (DSC) measurements were performed to characterize phase conditions of the mixtures in a temperature range of −120 to +100 °C. The viscosity data were fitted according to the Vogel-Fulcher-Tammann-Hesse (VFTH) equation and analyzed with the help of the fractional Walden rule. In this study, fundamental physicochemical data about the mixtures are provided and discussed as a basis for structure-property relationship calculations and for potential use of those mixtures as electrolytes for various applications. PMID:27153066

  19. Highly selective oxalate-membrane electrode based on 2,2'-[1,4-butandiyle bis(nitrilo propylidine)]bis-1-naphtholato copper(II).

    Science.gov (United States)

    Ardakani, M Mazloum; Jalayer, M; Naeimi, H; Heidarnezhad, A; Zare, H R

    2006-01-15

    A new oxalate-selective electrode based on the complex 2,2'-[1,4-butandiyle bis(nitrilo propylidine)]bis-1-naphtholato copper(II) (CuL) as the membrane carrier was developed. The electrode exhibited a good Nernstian slope of -29.2+/-0.6 mV/decade (mean value+/-standard deviation, n=5) and a linear range of 5.0 x 10(-8) to 1.0 x 10(-1)M for oxalate. The limit of detection was 5.0 x 10(-8)M. This electrode represents a fast response time (i.e. 10-15s) and could be used for more than 3 months. The selectivity coefficients were determined by the fixed interference method (FIM) and could be used in the pH range of 2.0-7.0. It was employed as an indicator electrode for the determination of oxalate in water samples.

  20. Highly luminescent, triple- and quadruple-stranded, dinuclear Eu, Nd, and Sm(III) lanthanide complexes based on bis-diketonate ligands

    NARCIS (Netherlands)

    Bassett, A.P.; Magennis, S.W.; Glover, P.B.; Lewis, D.J.; Spencer, N.; Parsons, S.; Williams, R.M.; De Cola, L.; Pikramenou, Z.

    2004-01-01

    The bis(beta-diketone) ligands 1,3-bis(3-phenyl-3-oxopropanoyl)benzene, H(2)L(1) and 1,3-bis(3-phenyl-3-oxopropanoyl) 5-ethoxy-benzene, H(2)L(2), have been prepared for the examination of dinuclear lanthanide complex formation and investigation of their properties as sensitizers for lanthanide

  1. Highly luminescent, triple- and quadruple-stranded, dinuclear Eu, Nd, and Sm(III) lanthanide complexes based on bis-diketonate ligands

    NARCIS (Netherlands)

    Bassett, A.P.; Magennis, S.W.; Glover, P.B.; Lewis, D.J.; Spencer, N.; Parsons, S.; Williams, R.M.; De Cola, L.; Pikramenou, Z.

    2004-01-01

    The bis(beta-diketone) ligands 1,3-bis(3-phenyl-3-oxopropanoyl)benzene, H2L1 and 1,3-bis(3-phenyl-3-oxopropanoyl) 5-ethoxy-benzene, H2L2, have been prepared for the examination of dinuclear lanthanide complex formation and investigation of their properties as sensitizers for lanthanide luminescence.

  2. A new route to the syntheses of alkali metal bis(fluorosulfuryl)imides: Crystal structure of LiN(SO2F)2

    Czech Academy of Sciences Publication Activity Database

    Beran, Martin; Příhoda, J.; Žák, Z.; Černík, M.

    2006-01-01

    Roč. 25, č. 6 (2006), s. 1292-1298 ISSN 0277-5387 Institutional research plan: CEZ:AV0Z40310501 Keywords : imido-bis( sulfuric acid ) difluoride * lithium bis(fluorosulfuryl)imide * alkali metal bis(fluorosulfuryl)imides Subject RIV: CA - Inorganic Chemistry Impact factor: 1.843, year: 2006

  3. Preparation of pseudo-arsonolipids: 2-acyloxypropane-1,3-bis(arsonic acids). The crystal structure of 2-hydroxypropane-1,3-bis(arsonic acid).

    Science.gov (United States)

    Terzis, Aris; Ioannou, Panayiotis V

    2002-08-01

    Epihalohydrins react with alkaline arsenite to give in very good yields 2-hydroxypropane-1,3-bis(arsonic acid) (7), a key compound for the synthesis of pseudo-arsonolipids and more complex arsinolipids. Through a series of reduction to -As(SPh)(2), acylation, and oxidation to -AsO(3)H(2), pseudo-arsonolipids, i.e. 2-acyloxypropane-1,3-bis(arsonic acids), were obtained. These pseudo-lipids are very sensitive to bases, being de-acylated. The bis(arsonic acid) (7) crystallizes in the orthorombic space group P2(1)2(1)2(1) with unit cell constants a=6.911(3), b=17.496(8), c=7.002(3) A. Both arsenic atoms are essentially tetrahedral being bound to three oxygens and one carbon. All hydrogen atoms have been located. There is no intramolecular but only intermolecular hydrogen bonding involving all the As=O, As-OH, and C-OH groups. The C-OH group acts as a hydrogen donor to an acidic As-OH, and this As-OH, in turn, acts as a hydrogen donor to an As=O group.

  4. Optical and magneto-optical properties of spin coated films of novel trinuclear bis(oxamato) and bis(oxamidato) type complexes

    Energy Technology Data Exchange (ETDEWEB)

    Abdulmalic, Mohammad A. [Technische Universität Chemnitz, Fakultät für Naturwissenschaften, Institut für Chemie, Straße der Nationen 62, D-09111 Chemnitz (Germany); Fronk, Michael [Technische Universität Chemnitz, Fakultät für Naturwissenschaften, Institut für Physik, Reichenhainer Straße 70, D-09107 Chemnitz (Germany); Bräuer, Björn [Stanford Institute of Materials and Energy Science, Stanford University, Stanford, CA 94025 (United States); Zahn, Dietrich R.T. [Technische Universität Chemnitz, Fakultät für Naturwissenschaften, Institut für Physik, Reichenhainer Straße 70, D-09107 Chemnitz (Germany); Salvan, Georgeta, E-mail: salvan@physik.tu-chemnitz.de [Technische Universität Chemnitz, Fakultät für Naturwissenschaften, Institut für Physik, Reichenhainer Straße 70, D-09107 Chemnitz (Germany); Eya' ane Meva, Francois [Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, BP 2701 (Cameroon); and others

    2016-12-01

    This work reports the first example of the spectroscopic measurements of the Magneto-Optical Kerr Effect (MOKE) of films being composed of trinuclear transition metal complexes on a non-transparent substrate at room temperature. The thin films of the tailor-made trinuclear bis(oxamidato) type complex 5 ([Cu{sub 3}(opbo{sup n}Pr{sub 2})(tmcd){sub 2}(NO{sub 3}){sub 2}], opbo{sup n}Pr{sub 2} = o-phenylenebis(N’-{sup n}propyloxamido, tmcd=trans-(1 R,2 R)-N,N,N′,N′-tetramethyl-cyclohexanediamine) and of the bis(oxamato) type complexes 11 ([Cu{sub 2}Ni(opbaCF{sub 3})(pmdta){sub 2}(NO{sub 3}){sub 2}], opbaCF{sub 3} = 4-trifluoromethyl-o-phenylenebis(oxamato), pmdta = N,N,N,′N″,N″-pentamethyldiethylenetriamine) and 12 ([Cu{sub 3}(opba)(bppe){sub 2}(NO{sub 3}){sub 2}] (opba = o-phenylenebis(oxamato), bppe = S-N,N-bis(2-picolyl)−1-phenylethylamine) were fabricated by spin-coating and their thicknesses in the range between 0.5 µm and 2 µm was determined by spectroscopic ellipsometry. Based on the spectroscopic ellipsometry results it was also possible to determine the optical constants of the film and compare them with the absorption of the complexes in solution in order to confirm the complex integrity after the film deposition. The fabrication of high-quality films which exhibit Kerr rotation up to 0.2 mrad (11.5 mdeg) was only possible due to tailor-made synthesis, which allows circumventing intermolecular interactions of the trinuclear complexes during the film formation. - Highlights: • Tailor-made trinuclear bis(oxamidato) and bis(oxamato) type complexes were synthesized. • Thin films (between 0.5 µm and 2 µm) were fabricated by spin-coating. • The film optical constants indicate the complex integrity after the deposition. • Film quality enabled first spectroscopic MOKE measurements of multi-nuclear complexes. • Magneto-optical Kerr rotation up to 11.5 mdeg was observed at RT (in 1.7 T).

  5. Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species.

    Science.gov (United States)

    Kotapati, Srikanth; Sangaraju, Dewakar; Esades, Amanda; Hallberg, Lance; Walker, Vernon E; Swenberg, James A; Tretyakova, Natalia Y

    2014-06-01

    Human carcinogen 1,3-butadiene (BD) undergoes metabolic activation to 3,4-epoxy-1-butene (EB), hydroxymethylvinyl ketone (HMVK), 3,4-epoxy-1,2-butanediol (EBD) and 1,2,3,4-diepoxybutane (DEB). Among these, DEB is by far the most genotoxic metabolite and is considered the ultimate carcinogenic species of BD. We have shown previously that BD-exposed laboratory mice form 8- to 10-fold more DEB-DNA adducts than rats exposed at the same conditions, which may be responsible for the enhanced sensitivity of mice to BD-mediated cancer. In the present study, we have identified 1,4-bis-(N-acetyl-L-cystein-S-yl)butane-2,3-diol (bis-BDMA) as a novel DEB-specific urinary biomarker. Isotope dilution high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was employed to quantify bis-BDMA and three other BD-mercapturic acids, 2-(N-acetyl-L-cystein-S-yl)-1-hydroxybut-3-ene/1-(N-acetyl-L-cystein-S-yl)-2-hydroxy-but-3-ene (MHBMA, from EB), 4-(N-acetyl-L-cystein-S-yl)-1,2-dihydroxybutane (DHBMA, from HMVK) and 4-(N-acetyl-L-cystein-S-yl)-1,2,3-trihydroxybutane (THBMA, from EBD), in urine of confirmed smokers, occupationally exposed workers and BD-exposed laboratory rats. Bis-BDMA was formed in a dose-dependent manner in urine of rats exposed to 0-200 p.p.m. BD by inhalation, although it was a minor metabolite (1%) as compared with DHBMA (47%) and THBMA (37%). In humans, DHBMA was the most abundant BD-mercapturic acid excreted (93%), followed by THBMA (5%) and MHBMA (2%), whereas no bis-BDMA was detected. These results reveal significant differences in metabolism of BD between rats and humans. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  6. Excited state reaction of [(2-carboxypyridinato)bis(2,2¢- bipyridine ...

    Indian Academy of Sciences (India)

    Administrator

    acid (PA) is used as the ligand, it is coordinated to the metal via the carboxylate ion and the nitrogen atom. In the present study we have synthesised [(2-carboxy- pyridinato)bis(2,2¢-bipyridine)ruthenium(II) ion [RuII(PA)(bpy)2]+ and studied the photophysics and PET reaction of tris-chelated heteroleptic ruthenium(II) ...

  7. Species dependence of [64Cu]Cu-Bis(thiosemicarbazone) radiopharmaceutical binding to serum albumins

    International Nuclear Information System (INIS)

    Basken, Nathan E.; Mathias, Carla J.; Lipka, Alexander E.; Green, Mark A.

    2008-01-01

    Introduction: Interactions of three copper(II) bis(thiosemicarbazone) positron emission tomography radiopharmaceuticals with human serum albumin, and the serum albumins of four additional mammalian species, were evaluated. Methods: 64 Cu-labeled diacetyl bis(N 4 -methylthiosemicarbazonato)copper(II) (Cu-ATSM), pyruvaldehyde bis(N 4 -methylthiosemicarbazonato)copper(II) (Cu-PTSM) and ethylglyoxal bis(thiosemicarbazonato)copper(II) (Cu-ETS) were synthesized and their binding to human, canine, rat, baboon and porcine serum albumins quantified by ultrafiltration. Protein binding was also measured for each tracer in human, porcine, rat and mouse serum. Results: The interaction of these neutral, lipophilic copper chelates with serum albumin is highly compound- and species-dependent. Cu-PTSM and Cu-ATSM exhibit particularly high affinity for human serum albumin (HSA), while the albumin binding of Cu-ETS is relatively insensitive to species. At HSA concentrations of 40 mg/ml, '% free' (non-albumin-bound) levels of radiopharmaceutical were 4.0±0.1%, 5.3±0.2% and 38.6±0.8% for Cu-PTSM, Cu-ATSM and Cu-ETS, respectively. Conclusions: Species-dependent variations in radiopharmaceutical binding to serum albumin may need to be considered when using animal models to predict the distribution and kinetics of these compounds in humans

  8. Iron(III) and copper(II) complexes of trans-bis(ferrocenyl)porphyrin

    Indian Academy of Sciences (India)

    Iron(III) and copper(II) complexes of trans-bis(ferrocenyl)porphyrin: Effect of metal ions on long-range electronic communication. Dipankar Sahoo Sankar Prasad Rath. Volume 127 Issue ... Keywords. Ferrocenylporphyrin; electrochemistry; spectro-electrochemistry; electrochemical conjugation; X-ray structure determination.

  9. Iron(III) and copper(II) complexes of trans-bis(ferrocenyl)porphyrin ...

    Indian Academy of Sciences (India)

    Iron(III) and copper(II) complexes of trans-bis(ferrocenyl)porphyrin: Effect of metal ions on long-range electronic communication. DIPANKAR SAHOO and SANKAR PRASAD RATH∗. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208 016, India e-mail: sprath@iitk.ac.in. MS received 12 December ...

  10. Bis(pyrrolo)tetrathiafulvalene - An Efficient Pi-Donor in Supramolecular Chemistry

    DEFF Research Database (Denmark)

    Lau, Jesper; Nielsen, Mogens Brøndsted; Thorup, Niels

    1999-01-01

    The synthesis of three novel macrocycles 3-5 based on the two electron donors bis(2,5-dimethyl- pyrrolo)[3,4-d]tetrathiafulvalene (1) and 1,4-hydroquinone is presented. Their abilities to include the electron acceptor paraquat (6) have been investigated by UV/Vis and sup 1 H NMR spectroscopy...

  11. New diastereomeric bis-sesquiterpenes from Hainan marine sponges Axinyssa variabilis and Lipastrotethya ana

    NARCIS (Netherlands)

    Mao, S.-C.; Manzo, E.; Guo, Y.-W.; Gavagnin, M.; Mollo, E.; Ciavatta, M.L.; van Soest, R.; Cimino, G.

    2007-01-01

    Three unprecedented diastereoisomeric dimers, cis-dimer A, cis-dimer B and trans-dimer C, exhibiting a bis-bisabolene skeleton, and a new sesquiterpene, dehydrotheonelline, their potential precursor, have been isolated from the South China Sea sponges Axinyssa variabilis and Lipastrotethya ana,

  12. Non bis in idem in Europa : de zaken Spasic en M.

    NARCIS (Netherlands)

    van Hattum, Wiene

    2015-01-01

    Binnen Schengen en de EU geldt de regel dat iemand die onherroepelijk is berecht niet nog eens mag worden vervolgd of gestraft wegens hetzelfde feit (non bis in idem). Geldt deze bescherming ook wanneer de straf wel definitief is geworden maar nog niet ten uitvoer is gelegd? Artikel 54 van de

  13. 15 CFR Appendix I to Part 700 - Form BIS-999-Request for Special Priorities Assistance

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Form BIS-999-Request for Special Priorities Assistance I Appendix I to Part 700 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE NATIONAL...

  14. Physiological effects in bovine lymphocytes of inhibiting polyamine synthesis with ethylglyoxal bis(guanylhydrazone).

    Science.gov (United States)

    Igarashi, K; Morris, D R

    1984-11-01

    Previous results have suggested that ethylglyoxal bis(guanylhydrazone) is a more specific inhibitor of polyamine biosynthesis than the widely used methylglyoxal bis(guanylhydrazone). The physiological effects on mitogenically activated lymphocytes of polyamine depletion with ethylglyoxal bis(guanylhydrazone) were examined. In the presence of ethylglyoxal bis(guanylhydrazone) and the ornithine decarboxylase inhibitor alpha-difluoromethylornithine, the cellular contents of putrescine, spermidine, and spermine were decreased by 75 to 90, 65 to 80, and 40 to 60%, respectively, compared with control cultures. Inhibition of DNA synthesis in these polyamine-deficient cells was always greater than that of protein synthesis. Upon addition of spermidine to the deficient cells, the cellular spermidine content was restored within 4 hr, but the complete recovery of macromolecular synthesis took 10 to 20 hr. Thymidine kinase and DNA polymerase alpha activities in polyamine-deficient cells were lower than those in normal cells, whereas RNA polymerase II and leucyl transfer RNA synthase activities were nearly equal to those in normal cells. These results and studies with 2-dimensional gel electrophoresis raise the possibility that polyamines may regulate the synthesis of specific proteins. Decreased synthesis of replication proteins in polyamine-deficient cells may be one reason for the reduced synthesis of DNA.

  15. Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases

    Directory of Open Access Journals (Sweden)

    Andrea Bistrović

    2017-11-01

    Full Text Available A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolylphenyl linker were synthesized by click chemistry. Whereas mono- 4g and bis-pseudopurine 5e showed selective inhibitory activities on cervical carcinoma (HeLa cells, bis-pyrrolo[2,3-d]pyrimidine 6b exhibited potent and selective anti-proliferative effect in the nanomolar range on pancreatic carcinoma (CFPAC-1 cells. Among these, compound 6b induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma and p38 MAP (mitogen-activated protein kinases. Our findings encourage further development of novel structurally related analog of 6b to obtain more selective anticancer agent for treating pancreatic cancer.

  16. Lecture notes on: Electrical theory behind the measurement of body fluids with bioimpedance spectroscopy (BIS)

    DEFF Research Database (Denmark)

    Jødal, Lars

    The lecture notes describe how body fluid volumes can be measured/estimated using the technique bio-impedance spectroscopy (BIS). The opening chapters assume little or none technical/mathematical knowledge and can hopefully be read by anyone interested in the techneque. Later chapters become more...

  17. Kinetics of substitution of cis-bis(malonato)diaquochromate(III) with ...

    African Journals Online (AJOL)

    In this process, it indicated that the substitution reaction occurs through an Ia mechanism in the amino acid dependent path and a dissociative mechanism in the independent path, showing the higher reactivity of single ended malonate complex. KEY WORDS: Substitution, cis-bis(Malonato)diaquochromate(III), Amino acids, ...

  18. Kinetic enantioselectivity of a protonated bis(diamido)-bridged basket resorcin[4]arene towards alanine peptides.

    Science.gov (United States)

    Fraschetti, C; Montagna, M; Crestoni, M E; Calcaterra, A; Aiello, F; Santi, L; Filippi, A

    2017-02-01

    Efficient enantiodiscrimination of some alanine-containing di- and tri-peptides by using chiral protonated bis(diamido)-bridged basket resorcin[4]arenes depends on several factors, including the basicity of the amino acid residues at the C- and N-termini of the peptide.

  19. Using bis(pinacolato)diboron to improve the quality of regioregular conjugated co-polymers

    NARCIS (Netherlands)

    Brouwer, Frank; Alma, Jan; Valkenier, Hennie; Voortman, Thomas P.; Hillebrand, Jorrit; Chiechi, Ryan C.; Hummelen, Jan C.

    2011-01-01

    We demonstrate the use of bis(pinacolato)diboron to directly polymerize symmetric, bisbromo, thiophene-based monomers via a Suzuki homo-polymerization to form co-polymers in less steps than the corresponding co-polymerization. We compare this method to the commonly used Stille co-polymerization by

  20. Die Freiheit ist grausam : die schwierige Geschichte der baltischen Staaten bis heute / Wilhelm Schmid

    Index Scriptorium Estoniae

    Schmid, Wilhelm

    1993-01-01

    Raamatututvustused: Marianna Butenschön. Estland, Lettland, Litauen : das Baltikum auf dem langen Weg in die Freiheit. München: Piper Verlag, 1992 (Serie Piper 1416). 367 S. ; Alexander Schmidt. Geschichte des Baltikums : von den alten Göttern bis zur Gegenwart. München : Piper Verlag, 1992. (Serie Piper 1518). 288 S.

  1. A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes

    OpenAIRE

    Doyle, Laurence R; Heath, Alex; Low, Choon Heng; Ashley, Andrew E

    2014-01-01

    1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-gram syntheses, utilises readily available and inexpensive reagents, and benefits from a facile non-aqueous work-up in the final reductive step.

  2. Bis-phosphine allene ligand: coordination chemistry and preliminary applications in catalysis.

    Science.gov (United States)

    Vanitcha, Avassaya; Damelincourt, Cecilia; Gontard, Geoffrey; Vanthuyne, Nicolas; Mouriès-Mansuy, Virginie; Fensterbank, Louis

    2016-05-21

    A 1,3-bis-diphenylphosphine allene can give rise to new coordination complexes with palladium, platinum and gold metals. These complexes were fully characterized by NMR, HRMS and X-ray diffraction analysis. For gold(i), the corresponding dinuclear complex has been used in a series of diagnostic catalytic reactions and gave promising preliminary results in asymmetric catalysis.

  3. Synthesis, stereochemistry, and photochemical and thermal behaviour of bis-tert-butyl substituted overcrowded alkenes

    NARCIS (Netherlands)

    K. J. Ter Wiel, M.; G. Kwit, M.; Meetsma, A.; Feringa, B.L.

    2007-01-01

    In order to study the structural limits in the design of molecular motors, a tert-butyl substituted analogue was prepared. The unexpected photochemical and thermal isomerisation processes and the stereochemistry of new overcrowded alkene 5 are described. The bis tert-butyl substituted alkenes were

  4. Reversible gel-sol photoswitching with an overcrowded alkene-based bis-urea supergelator

    NARCIS (Netherlands)

    Wezenberg, Sander J.; Croisetu, Christelle M.; Stuart, Marc C. A.; Feringa, Ben L.

    2016-01-01

    A new type of low-molecular-weight gelator (LMWG), i.e. overcrowded alkene-based bis-ureas, can be switched effectively between cis and trans isomers using light as demonstrated by H-1 NMR and UV-Vis spectroscopy. Gelation studies reveal that one of the synthesized trans compounds forms stable gels

  5. Mechanical properties of polyethersulfone modified epoxy/3, 3′-bis ...

    Indian Academy of Sciences (India)

    ... Lecture Workshops · Refresher Courses · Symposia. Home; Journals; Bulletin of Materials Science; Volume 31; Issue 6. Mechanical properties of polyethersulfone modified epoxy/3,3′-bis (maleimidophenyl)phenylphosphine oxide (BMI) intercrosslinked matrices. R Rajasekaran M Alagar. Mechanical Properties Volume ...

  6. N-doping of organic semiconductors by bis-metallosandwich compounds

    Science.gov (United States)

    Barlow, Stephen; Qi, Yabing; Kahn, Antoine; Marder, Seth; Kim, Sang Bok; Mohapatra, Swagat K.; Guo, Song

    2016-01-05

    The various inventions disclosed, described, and/or claimed herein relate to the field of methods for n-doping organic semiconductors with certain bis-metallosandwich compounds, the doped compositions produced, and the uses of the doped compositions in organic electronic devices. Metals can be manganese, rhenium, iron, ruthenium, osmium, rhodium, or iridium. Stable and efficient doping can be achieved.

  7. A Bis-Calix[4]pyrrole Enzyme Mimic that Constrains Two Oxoanions in Close Proximity

    DEFF Research Database (Denmark)

    He, Qing; Kelliher, Michael; Bähring, Steffen

    2017-01-01

    Herein we describe a large capsule-like bis-calix[4]pyrrole 1 , that is able to host concurrently two dihydrogen phosphate anions within a relatively large internal cavity. Evidence for the concurrent, dual recognition of the encapsulated anions came from 1H NMR and UV-vis spectroscopies and ITC ...

  8. Synthesis, characterization and behaviour of trans-bis (argininate) copper (II) to gamma radiation

    International Nuclear Information System (INIS)

    Pereira, A.B.

    1984-01-01

    The synthesis, the characterization and the behaviour to gamma radiation of trans-bis (argininate) copper (II) are presented. The synthesis is made from copper sulfate, sodium hydroxide and hydrochloride of L (+) arginine, in aqueous medium, and the characterization by infrared spectroscopy, visible and ultraviolet spectroscopy and elementary analysis. (C.G.C.)

  9. An efficient and facile synthesis of divergent C-3/C-5 bis ...

    Indian Academy of Sciences (India)

    extensive attention in organic synthesis and also serve as potential synthons for the synthesis of alkaloids, ... recent years, MBH adduct of oxindole has attracted attention due to its significance of multi-functionalized ...... scope, rate acceleration and selective formation of bis-. MBH adduct with cyclic enones with DABCO as ...

  10. Synthesis and applications of gem-bis-phosphonates, powerful complexing agents of metals

    International Nuclear Information System (INIS)

    Lecercle, D.

    2007-12-01

    This thesis was devoted to the development of new ways to prepare gem-bis-phosphonates compounds (BPs), and was carried out under the Program of Nuclear and Environmental Toxicology (ToxNuc-E). Two applications of these compounds have been investigated, the preparation of potent ligands of the uranyl ion for a target of decorporation, and the preparation of new anticancer compounds. The first of these applications was the consequence of work done in the laboratory, that have shown the strong uranium-binding properties of bis-phosphonic ligands. The in vivo tests performed on these compounds have shown the tendency of these ligands to cause liver accumulation of uranium, we wanted to address this problem by modifying the method of anchoring of the bis-phosphonates functions. To this end we have developed a new way to access to these compounds using a metal-carbenoid mediated poly-ols and poly-amines insertion, the metal-carbenoid species bearing the bis-phosphonate function. Regarding the preparation of BPs as anticancer agents, we have developed a new synthetic pathway using a phosphine catalyzed α-P addition of phosphorated pro-nucleophiles to alkynyl-phosphonates as a key step. This enabled us to prepare thirty compound whose activity was evaluated on two cell lines (A431 and HuH7). Five of these compounds possess an activity equivalent to that of the compound described as the most active, the Zoledronate. (author)

  11. In Vitro Human Metabolism of the Flame Retardant Resorcinol Bis(diphenylphosphate) (RDP)

    NARCIS (Netherlands)

    Ballesteros-Gomez, A.M.; Van den Eede, N.; Covaci, A.

    2015-01-01

    Resorcinol bis(diphenylphosphate) (RDP) is widely used as a flame retardant in electrical/electronic products and constitutes a suitable alternative to decabrominated diphenyl ether. Due to its toxicity and its recently reported ubiquity in electronics and house dust, there are increasing concerns

  12. Bis(imino)pyridine (BIMP) Fe(II) catalyses one-pot green ...

    Indian Academy of Sciences (India)

    483–486. c Indian Academy of Sciences. Bis(imino)pyridine (BIMP) Fe(II) catalyses one-pot green condensation of resorcinol, malononitrile, aromatic aldehydes and cyclohexanone. SAMAN DAMAVANDIa,∗ and REZA SANDAROOSb. aDepartment of Chemistry, Sarvestan Branch, Islamic Azad University, Sarvestan, Iran.

  13. Investigation of Keto-enol Tautomers during the Synthesis of Aryl-bis ...

    Indian Academy of Sciences (India)

    This study investigated the existence of keto-enol tautomers for the first time during the synthesis of aryl-bis(2-hydroxy-1-naphthyl)methane from 2-naphthol and -tolualdehyde or 4-chlorobenzaldehyde in methanol using CuSO4.5H2O as catalyst under reflux condition. The exclusive formation of ...

  14. A New Copper (I) Complex Based on 4-amino-3, 5-bis (3-pyridyl)-1 ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences; Volume 129; Issue 2. A New Copper(I) Complex Based on 4-amino-3,5-bis(3-pyridyl)-1,2,4-triazole: Synthesis, Crystal Structure, Theoretical Study, Thermal Behavior and Luminescence. CHEN AI-HUA MENG SU-CI ZHOU KAI WANG CONG-CONG ZHAO WEI WANG AI-JIAN ...

  15. Ne2 encodes protein(s) and the altered RuBisCO could be the ...

    Indian Academy of Sciences (India)

    Si Rui Pan

    2017-06-17

    Jun 17, 2017 ... Wheat hybrid necrosis is caused by the interaction of two dominant complementary genes, Ne1 and Ne2, located on ... hypothetical model presents the RuBisCO pathway of hybrid necrosis in wheat and explains how Ne1 and Ne2 interact ... were rinsed with distilled water, then cut/wrapped/labelled.

  16. Synthesis of Ethylene Bis-stearamide for Acrylonitrile-Butadiene-Styrene Polymer

    Directory of Open Access Journals (Sweden)

    M.A. Sayyadnejad

    2009-12-01

    Full Text Available Ethylene bis-stearamide is one of the important acrylonitrile-butadiene-styrene (ABS( polymer additives, which is used as lubricant, slip agent and mold release agent. In this research, ethylene bis-stearamide for ABS application was synthesized using stearic acid and ethylene diamine under reflux condition. Refluxing prevented ethylenediamine from evaporation and thus the initial molar ratio was maintained unchanged. The other role of refluxing was to prevent the oxidation of ethylene diamine by removal of oxygen which might have been present inside the reactor. The synthesized samples were characterized by Fourier transform infrared spectroscopy (FTIR(, total acid number and melting point. The total acid number of the synthesized samples in the lab, bench scale 1 kg( and pilot scale 30 kg( were 6.5, 8.7 and 8.6 mgKOH/g, respectively, and their melting points were in 141-144 °C range. It was found that total acid number values of samples are inversely proportional with reaction time. The longer the reaction time, the higher was the total acid number and sample purity. Compounding was carried out using ABS containing synthesized and reference ethylene bis-stearamide and the physical-mechanical properties of the samples were measured. The obtained results showed that, the measured properties such as melt flow index, impact resistance, softening temperature, heat deflection temperature, tensile strength and hardness for the compound prepared using synthesized ethylene bis-stearamide match very well with those of reference compound.

  17. Ne2 encodes protein (s) and the altered RuBisCO could be the ...

    Indian Academy of Sciences (India)

    ) and the altered RuBisCO could be the ... Understanding the proteomic pathways may provide a knowledge base for protecting or maximizing the photosynthesis capacity of wheat. Using DIGE and MALDITOF-TOF MS, the flag leaf protein ...

  18. Is Cytox 3522 (10% methylene-bis-thiocyanate) a human skin sensitizer?

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Hamann, K

    1983-01-01

    Methylene-bis-thiocyanate is an antimicrobial agent in Cytox 3522 (American Cyanamid Corporation) and Nalco 206 (Nalco Chemical Company). Both are wide-spectrum industrial biocides. Cytox 3522 showed a strong sensitization potential in guineau pigs using the Guinea Pig Maximization Test and the O...

  19. Coordination-assembly for quantitative construction of bis-branched molecular shuttles.

    Science.gov (United States)

    Zhu, Liangliang; Lu, Meiqun; Qu, Dahui; Wang, Qiaochun; Tian, He

    2011-06-07

    The development and utilization of a new way to build molecular devices is of importance. To build a novel topology of interlocked molecular systems with a controllable mechanical motion, an axle-like compound comprising azobenzene and alkoxy isophthalate moieties was synthesized first. It would form a switchable hemi-rotaxane structure with α-cyclodextrin (α-CD) ring encapsulated in aqueous solution. Next, the hemi-rotaxane was reacted with ethylene diamine palladium nitrate (Pd(en)(NO(3))(2)) and ethylene diamine platinum nitrate (Pt(en)(NO(3))(2)), respectively, to quantitatively form two bis-branched molecular shuttles in situ. The bis-coordinated Pd(II) complex was formed quickly at room temperature, whereas the bis-coordinated Pt(II) one was effectively treated at 333 K but more stable than the former. In this case, transformation of ring shuttling direction could take place in the stable bis-branched Pt(II) complex. The steric effect of the co-stopper, namely the Pt(II) metal center, made the α-CD ring dynamically shuttle inwards to the alkoxy isophthalate station with the azobenzene's photoisomerization, rather than dethreading from the axle.

  20. Preparation of tritium labelled synthanecine A and its bis-N-ethylcarbamate

    Energy Technology Data Exchange (ETDEWEB)

    Mattocks, A.R. (Medical Research Council, Carshalton (UK))

    1982-04-01

    A procedure is described for incorporating tritium into the 3-CH/sub 2/ side chain of synthanecine A, and preparing the carbamate, 2,3-bis-N-ethylcarbamoyloxymethyl-1-methyl-3-pyrroline, a hepatotoxic pyrrolizidine alkaloid analogue. The pyrrolizidine amino alcohol, retronecine, can be tritium labelled in a similar way.

  1. Preparation of tritium labelled synthanecine A and its bis-N-ethylcarbamate

    International Nuclear Information System (INIS)

    Mattocks, A.R.

    1982-01-01

    A procedure is described for incorporating tritium into the 3-CH 2 side chain of synthanecine A, and preparing the carbamate, 2,3-bis-N-ethylcarbamoyloxymethyl-1-methyl-3-pyrroline, a hepatotoxic pyrrolizidine alkaloid analogue. The pyrrolizidine amino alcohol, retronecine, can be tritium labelled in a similar way. (author)

  2. Synthesis and structure of bis(β-dibenzoyl methanato -O,O') (aquo-O ...

    Indian Academy of Sciences (India)

    Synthesis and structure of bis(β-dibenzoyl methanato -O,O') (aquo-O) dioxouranium (VI) compound ... Keywords. β-diketonates; uranyl ion; adduct compound; crystal structure; hydrogen bonding. 1. Introduction. Structural studies on uranyl ... crystalline product obtained was filtered, washed with ether and dried. The crystal ...

  3. 1,5-Bis (2-Hydroxyphenyl)Pent-1,4-Diene-3-One: A Lead ...

    African Journals Online (AJOL)

    NJD

    occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent-1,4-diene-3-one (1c) as a lead compound with potential against a panel of pathogenic bacterial strains, ...

  4. Synthesis and characterization of solid complexes of thorium, uranyl perchlorates with bis-quinolylmethylene

    International Nuclear Information System (INIS)

    He Liangyou; Tang Ning; Gan Xinmin; Tan Minyu

    1990-01-01

    The solid complexes of thorium, uranyl perchlorates with bis-quinolylmethylene (Biqm) having the composition Th(Biqm) 5 (ClO 4 ) 4 , UO 2 (Biqm) 2 (ClO 4 ) 2 have been synthesized in nonaqueous solvents. These two complexes have been characterized by elemental analysis, IR and UV spectra, differential thermal analysis (DTA) and thermogravimetry (TG), fluorescence spectra and molar conductances

  5. Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitrile using bis(imidazoline)-Pd catalysts.

    Science.gov (United States)

    Kondo, Masaru; Sugimoto, Mami; Nakamura, Shuichi

    2016-11-15

    The catalytic enantioselective Mannich-type reaction of dichloroacetonitrile with imines has been developed. Good yields and enantioselectivity were observed for the reaction with various imines using chiral bis(imidazoline) catalysts. β-Aminonitriles or β-aminoamide were obtained from products without the loss of enantiopurity.

  6. Stereochemically rich pentaketides from bis(isoxazolines): a general strategy for efficient polyketide synthesis.

    Science.gov (United States)

    Fader, Lee D; Carreira, Erick M

    2004-07-08

    [reaction: see text] A strategy based on diastereoselective dipolar cycloaddition reaction of nitrile oxides and allylic alcoholates has been applied to the synthesis of bis(isoxazolines) that are precursors to polyketide fragments. These intermediates can be elaborated into protected polyols by chemoselective reductive opening of each isoxazoline sequentially or, alternatively, both simultaneously, potentially providing access to all stereoisomers of this carbon skeleton.

  7. Structural characterization and catalytic properties of bis(1,1,3,3-tetramethylguanidinium) dichromate

    DEFF Research Database (Denmark)

    Due-Hansen, Johannes; Ståhl, Kenny; Boghosian, Soghomon

    2011-01-01

    The structure of bis(1,1,3,3-tetramethylguanidinium) dichromate was determined from powder X-ray diffraction data. The compound crystallizes in the monoclinic system (space group P21/n) with a = 10.79714 (15) Å, b = 11.75844 (16) Å, c = 8.15097 (11) Å, β = 109.5248 (6)º. The structure consists of...

  8. Bis(pyrrolo)tetrathiafulvalene - An Efficient Pi-Donor in Supramolecular Chemistry

    DEFF Research Database (Denmark)

    Lau, Jesper; Nielsen, Mogens Brøndsted; Thorup, Niels

    1999-01-01

    The synthesis of three novel macrocycles 3-5 based on the two electron donors bis(2,5-dimethyl- pyrrolo)[3,4-d]tetrathiafulvalene (1) and 1,4-hydroquinone is presented. Their abilities to include the electron acceptor paraquat (6) have been investigated by UV/Vis and sup 1 H NMR spectroscopy and ...

  9. Solid state photodimerization in an organic salt of 1,2-bis(4-pyridyl ...

    Indian Academy of Sciences (India)

    Abdul Malik P Peedikakkal

    photochemical reactions such as requiring parallel ori- entation of photoreactive double bonds with centroid distance between 3.5–4.2 Å.2 The crystal engineering principles are effectively utilized to orient the C=C bonds of bpe (bpe = trans-1,2-bis(4-pyridyl)ethylene) in the solid state for photodimerization reactions.1c−d, ...

  10. Ora-pro-nóbis em uso alimentar humano: percepção sensorial

    Directory of Open Access Journals (Sweden)

    Carla Regina Amorim dos Anjos Queiroz

    2015-07-01

    Full Text Available O governo brasileiro incentiva o consumo de hortaliças não convencionais, como forma de aproveitamento da biodiversidade brasileira e suprimento de necessidades nutricionais de forma viável a população, principalmente a de baixa renda. A Ora-pro-nóbis (Pereskia aculeata Miller é uma hortaliça nativa brasileira que se propaga facilmente, cujo cultivo apresenta baixa incidência de doenças e de demanda hídrica. É viável para o cultivo doméstico, como fonte nutricional alternativa e de baixo custo, sendo uma hortaliça recomendada para o consumo diário na alimentação, nas formas crua e/ou processada. Neste trabalho, buscou-se ampliar o uso o e cultivo da Ora-pro-nóbis, com a produção e distribuição de mudas em um evento tradicional na Zona Rural de Uberlândia, a Semana da Família Rural, em sua 26ª edição, no Instituto Federal do Triângulo Mineiro – Campus Uberlândia. Durante o evento foram distribuídas amostras de alimentos processados com folhas de Ora-pro-nóbis in natura ou previamente secas, para degustação e avaliação da apreciação. Também foram distribuídas mudas de Ora-pro-nóbis aos interessados, mediante cadastro prévio. Os dados apresentados revelaram interesse da população no uso da planta e a aceitação dos produtos incrementados com as folhas da planta, uma vez que de 600 pessoas participantes, 232 participaram da degustação de pelo menos um produto alimentício e 156 levaram mudas para o plantio.Ora-pro-nóbis in human food consumption: sensorial perceptionAbstract: Brazilian government encourages the consume unconventional vegetables to avail the biodiversity from the country and nourish the population, mainly the low-income people. Ora-pro-nóbis (Pereskia aculeata Miller is a brazilian native vegetable which is easily propagated and has low diseases and low request water rates. As a low-cost nutritional source, this vegetable is viable to home cultivation and recommended for the daily

  11. Induction of spermidine/spermine N1-acetyltransferase by methylglyoxal bis(guanylhydrazone).

    Science.gov (United States)

    Pegg, A E; Erwin, B G; Persson, L

    1985-10-17

    The anti-tumor agent methylglyoxal bis(guanylhydrazone) was found to be a competitive inhibitor of spermidine/spermine N1-acetyltransferase with a Ki of about 8 microM. Treatment of rats with this drug lead to a very large increase in the total amount of spermidine/spermine N1-acetyltransferase in liver, kidney and spleen. The total increase as measured using a specific antiserum amounted to 700-fold in liver and 100-fold in kidney within 18 h of treatment with 80 mg/kg doses. At least part of this induction was due to a pronounced increase in the half-life of the acetyltransferase which increased from 15 min to more than 12 h. The very large increase in the amount of the enzyme is likely to overwhelm the direct inhibition, and a net increase in the acetylation of polyamines by this enzyme would be expected to occur after treatment with methylglyoxal bis(guanylhydrazone). The acetylated polyamines are known to be rapidly degraded by polyamine oxidase producing putrescine. Direct evidence that a substantial part of the increase in the content of putrescine in the liver of rats treated with methylglyoxal bis(guanylhydrazone) occurs via the induction of this acetylase/oxidase pathway was obtained. These results indicate that methylglyoxal bis(guanylhydrazone) affects cellular polyamine levels not only by means of its inhibitory effect on S-adenosylmethionine decarboxylase and diamine oxidase but also by the induction of spermidine/spermine N1-acetyltransferase. They also raise the possibility that the enormous increase in this enzyme which occurs with higher doses may contribute to the very severe toxicity of methylglyoxal bis(guanylhydrazone).

  12. Psychometric Properties of the BIS/BAS Scales and the SPSRQ in Flemish Adolescents

    Directory of Open Access Journals (Sweden)

    Laura Vandeweghe

    2016-12-01

    Full Text Available Objective: Gray’s Reinforcement Sensitivity Theory (RST is a frequently used model of personality that is relevant to the period of adolescence. However, the psychometric properties of the most frequently used questionnaires to measure the RST-constructs, namely the Behavioural Inhibition System and Behavioural Activation System Scales (BIS/BAS Scales and the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ, are rarely examined in samples of adolescents. Therefore, the goal of the present study was to examine the two-factor structure, reliability and convergent validity of the BIS/BAS Scales and SPSRQ in a Flemish adolescent community sample.  Method: A sample of 579 adolescents (39.5% boys; 14–19 years was recruited. The proposed two-factor structure was assessed using Exploratory Structural Equation Modeling. Reliability was evaluated using internal consistency and construct validity was examined with the correlations between the two questionnaires and with the Temperament and Character Inventory–short form (TCI-SF.  Results: After the removal of problematic items, and the addition of correlated errors, all indices indicated a good fit for the two-factor structure of the modified BIS/BAS Scales. For the modified SPSRQ, three fit indices indicated a good model fit, while a fourth fit index was slightly below the cut-off score of an adequate model fit. Internal consistency of both questionnaires was sufficient. In general, the associations with scales of the TCI-SF were as expected, with positive correlations between BIS-related scales, and between BAS-related scales of all three instruments.  Discussion: In Flemish adolescents, the use of a two-factor model to analyze data gathered with the modified BIS/BAS Scales or modified SPSRQ seems appropriate.

  13. Developmental defects of coronary vasculature in rat embryos administered bis-diamine.

    Science.gov (United States)

    Hanato, Takashi; Nakagawa, Masao; Okamoto, Nobuhiko; Nishijima, Setsuko; Fujino, Hidetoshi; Shimada, Morimi; Takeuchi, Yoshihiro; Imanaka-Yoshida, Kyoko

    2011-02-01

    Conotruncal anomalies are often associated with abnormal coronary arteries. Although bis-diamine is known to induce conotruncal defects, its pathological effects on coronary vascular development have not been demonstrated. This study sought to assess the teratogenic effects of bis-diamine on coronary vascular development and the pathogenesis of this anomalous association. A single 200 mg dose of bis-diamine was administered to pregnant Wistar rats at 10.5 days of gestation. Fifty-two embryos from 10 mother rats underwent morphological analysis of the coronary arteries. Three embryos each were removed from four mothers on embryonic days (ED) 14.5, 15.5, 16.5, and 17.5 and used for immunohistochemical studies using the anti-vascular cell adhesion molecule (VCAM)-1 antibody. Conotruncal anomalies were detected in 48 of 52 embryos, and an aplastic or hypoplastic left coronary artery was found in all of them. In control embryos at ED 16.5, VCAM-1-positive epicardial cells were transformed into mesenchymal cells in vascular plexus, which appeared to differentiate into the endothelial cells of coronary vasculature. In the heart at ED 17.5, coronary vasculature was well developed and connected with coronary ostia near the aorta. However, poor epicardial-mesenchymal transformation and subsequent differentiation was revealed in bis-diamine-treated embryos at EDs 16.5 and 17.5, causing abnormal development of the coronary vasculature and incomplete connections with coronary ostia of the aorta. Anomalous coronary arteries in the bis-diamine-treated embryos are induced by the disruption of epicardial-mesenchymal transformation and subsequent poor development of coronary vasculature. Incomplete hatching of the coronary ostium is associated with abnormal truncal division. © 2010 Wiley-Liss, Inc.

  14. Synthesis, characterization, and reactivity of furan- and thiophene-functionalized bis(n-heterocyclic carbene) complexes of iron(II)

    KAUST Repository

    Rieb, Julia

    2014-09-15

    The synthesis of iron(II) complexes bearing new heteroatom-functionalized methylene-bridged bis(N-heterocyclic carbene) ligands is reported. All complexes are characterized by single-crystal X-ray diffraction (SC-XRD), nuclear magnetic resonance (NMR) spectroscopy, and elemental analysis. Tetrakis(acetonitrile)-cis-[bis(o-imidazol-2-ylidenefuran)methane]iron(II) hexafluorophosphate (2a) and tetrakis(acetonitrile)-cis-[bis(o-imidazol-2-ylidenethiophene)methane]iron(II) hexafluorophosphate (2b) were obtained by aminolysis of [Fe{N(SiMe3)2}2(THF)] with furan- and thiophene-functionalized bis(imidazolium) salts 1a and 1b in acetonitrile. The SC-XRD structures of 2a and 2b show coordination of the bis(carbene) ligand in a bidentate fashion instead of a possible tetradentate coordination. The four other coordination sites of these distorted octahedral complexes are occupied by acetonitrile ligands. Crystallization of 2a in an acetone solution by the slow diffusion of Et2O led to the formation of cisdiacetonitriledi[ bis(o-imidazol-2-ylidenefuran)methane]iron(II) hexafluorophosphate (3a) with two bis(carbene) ligands coordinated in a bidentate manner and two cis-positioned acetonitrile molecules. Compounds 2a and 2b are the first reported iron(II) carbene complexes with four coordination sites occupied by solvent molecules, and it was demonstrated that those solvent ligands can undergo ligand-exchange reactions.

  15. Expression and purification of the modification-dependent restriction enzyme BisI and its homologous enzymes.

    Science.gov (United States)

    Xu, Shuang-Yong; Klein, Pernelle; Degtyarev, Sergey Kh; Roberts, Richard J

    2016-06-29

    The methylation-dependent restriction endonuclease (REase) BisI (G(m5)C ↓ NGC) is found in Bacillus subtilis T30. We expressed and purified the BisI endonuclease and 34 BisI homologs identified in bacterial genomes. 23 of these BisI homologs are active based on digestion of (m5)C-modified substrates. Two major specificities were found among these BisI family enzymes: Group I enzymes cut GCNGC containing two to four (m5)C in the two strands, or hemi-methylated sites containing two (m5)C in one strand; Group II enzymes only cut GCNGC sites containing three to four (m5)C, while one enzyme requires all four cytosines to be modified for cleavage. Another homolog, Esp638I cleaves GCS ↓ SGC (relaxed specificity RCN ↓ NGY, containing at least four (m5)C). Two BisI homologs show degenerate specificity cleaving unmodified DNA. Many homologs are small proteins ranging from 150 to 190 amino acid (aa) residues, but some homologs associated with mobile genetic elements are larger and contain an extra C-terminal domain. More than 156 BisI homologs are found in >60 bacterial genera, indicating that these enzymes are widespread in bacteria. They may play an important biological function in restricting pre-modified phage DNA.

  16. Behavioural Inhibition System (BIS) sensitivity differentiates EEG theta responses during goal conflict in a continuous monitoring task.

    Science.gov (United States)

    Moore, Roger A; Mills, Matthew; Marshman, Paul; Corr, Philip J

    2012-08-01

    Previous research has revealed that EEG theta oscillations are affected during goal conflict processing. This is consistent with the behavioural inhibition system (BIS) theory of anxiety (Gray & McNaughton, 2000). However, studies have not attempted to relate these BIS-related theta effects to BIS personality measures. Confirmation of such an association would provide further support for BIS theory, especially as it relates to trait differences. EEG was measured (32 electrodes) from extreme groups (low/high trait BIS) engaged in a target detection task. Goal conflicts were introduced throughout the task. Results show that the two groups did not differ in behavioural performance. The major EEG result was that a stepwise discriminant analysis indicated discrimination by 6 variables derived from coherence and power, with 5 of the 6 in the theta range as predicted by BIS theory and one in the beta range. Also, across the whole sample, EEG theta coherence increased at a variety of regions during primary goal conflict and showed a general increase during response execution; EEG theta power, in contrast, was primarily reactive to response execution. This is the first study to reveal a three-way relationship between the induction of goal conflict, the induction of theta power and coherence, and differentiation by psychometrically-defined low/high BIS status. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Effects of phenylated compounds of methylglyoxal bis(guanylhydrazone) on diamine oxidase activity from rat small intestine.

    Science.gov (United States)

    Balaña-Fouce, R; Pulido, T G; Escudero, D O; Sanz-Sanchez, F

    1986-01-01

    Two phenylated compounds of methylglyoxal bis(guanylhydrazone), potentially inhibitors of diamine oxidase activity, have been synthesized: phenylglyoxal bis(guanylhydrazone) and diphenylglyoxal bis(guanylhydrazone). Their inhibitory capacity was tested: while PGBG was able to reduce the enzyme activity by 50% at 1.3 microM, DPGBG was only able to reduce diamine oxidase activity by less than 2% at a concentration 1000-fold higher. The inhibition of PGBG was non-competitive and the Ki calculated by a Dixon plot was estimated as 1.7 microM.

  18. Fluorescent reactions of zirconium and zinc ions with salicylaldehyde formylhydrazone

    International Nuclear Information System (INIS)

    Alykov, N.M.

    1980-01-01

    Complexing of zirconium and zinc ions with salicylaldenyde formylhydrazone (HR) in aqueous solutions has been studied fluorimetrically. Zirconium and zinc react With HR to form fluorescent compounds at pH 2.0 and 6.25 respectiVely. The composition and stability constants of the complexes have been determined

  19. BOOK REVIEW: Meilensteine der Astronomie - Von Aristoteles bis Hawking

    Science.gov (United States)

    Duerbeck, H. W.; Hamel, J.

    2006-12-01

    A writer, more specific a writer on the history of astronomy, might from time to time look at the collected document folders with all the research material and reprints, and might wonder: has this been all? Especially at a time when recycling is in vogue? And, perhaps with a request or an invitation to submit something, he or she might consider re-using the material before its definitive disposal. Well, such are my feelings when I looked at Jurgen Hamel's new book Milestones of Astronomy - From Aristoteles to Hawking . A slight chance for survival of medium-sized publishers like Kosmos is to offer popular books, and a title must attract potential buyers: Aristoteles means the "old" times, and as concerns the "mad scientist" of modern times, Stephen Hawking has by now dethroned Einstein. In 1998, Hamel had published a Geschichte der Astronomie - Von den Anfangen bis zur Gegenwart (History of astronomy, from the beginnings to the present), which, of course, he could not simply copy. This time, he selected some stones from his research areas - milestones, touchstones, stumbling blocks in the long road of astronomical evolution - and put them between the covers of his new book. So let us look at these (mile)stones . The reader is informed about Aristoteles on 2 pages, but his medieval interpreter Johannes de Sacrobosco gets 8 pages! Copernicus' life and achievements are described on 9 pages, closely followed by his devotee and translator Rothmann with 8 pages; Copernicus' contemporary, Peter Apian, however, gets about 13! Bessel's and Herschel's lifes and works are described on well-deserved 13 and 15 pages, while the achievements of the two Lucasian professors, Isaac Newton and Stephen Hawking, are just outlined in a single paragraph! Thus, importance is sometimes inversely proportional to text length... But let us become serious now. Why should an active historian outline, for the hundreth time, the life of Copernicus, while there are so many interesting, and often

  20. Crystal structure of bis[2,5-bis(pyridin-2-yl-1,3,4-thiadiazole-κ2N2,N3]bis(thiocyanato-κScopper(II

    Directory of Open Access Journals (Sweden)

    Abdelhakim Laachir

    2016-08-01

    Full Text Available The mononuclear title complex, [Cu(SCN2(C12H8N4S2], was obtained by the reaction of 2,5-bis(pyridin-2-yl-1,3,4-thiadiazole and potassium thiocyanate with copper(II chloride dihydrate. The copper cation lies on an inversion centre and displays an elongated octahedral coordination geometry. The equatorial positions are occupied by the N atoms of two 2,5-bis(pyridin-2-yl-1,3,4-thiadiazole ligands, whereas the axial positions are occupied by the S atoms of two thiocyanate anions. The thiadiazole and the pyridyl rings linked to the metal are approximately coplanar, with a maximum deviation from the mean plane of 0.190 (2 Å. The cohesion of the crystal structure is ensured by weak C—H...N hydrogen bonds and π–π interactions between parallel pyridyl rings of neighbouring molecules [centroid-to-centroid distance = 3.663 (2 Å], leading to a three-dimensional network.

  1. (μ-Acetato-κ2O:O′[μ-2,6-bis({bis[(pyridin-2-yl-κNmethyl]amino-κN}methyl-4-methylphenolato-κ2O:O](methanol-κOdizinc bis(perchlorate

    Directory of Open Access Journals (Sweden)

    Biswanath Das

    2014-04-01

    Full Text Available The binuclear title complex, [Zn2(C33H33N6O(CH3COO2(CH3OH](ClO42, was synthesized by the reaction between 2,6-bis({[bis(pyridin-2-ylmethyl]amino}methyl-4-methylphenol (H-BPMP, Zn(OAc2 and NaClO4. The two ZnII ions are bridged by the phenolate O atom of the octadentate ligand and the acetate group. An additional methanol ligand is terminally coordinated to one of the ZnII ions, rendering the whole structure unsymmetric. Other symmetric dizinc complexes of BPMP have been reported. However, to the best of our knowledge, the present structure, in which the two ZnII ions are distinguishable by the number of coordinating ligands and the coordination geometries (octahedral and square-pyramidal, is unique. The dizinc complex is a dication, and two perchlorate anions balance the charge. The –OH group of the coordinating methanol solvent molecule forms a hydrogen bond with a perchlorate counter-anion. One of the anions is disordered over two sets of sites with an occupancy ratio of 0.734 (2:0.266 (2.

  2. Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.

    Science.gov (United States)

    Asquith, Christopher R M; Meli, Marina L; Konstantinova, Lidia S; Laitinen, Tuomo; Peräkylä, Mikael; Poso, Antti; Rakitin, Oleg A; Allenspach, Karin; Hofmann-Lehmann, Regina; Hilton, Stephen T

    2014-06-15

    A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  3. An evaluation of the relationship between Gray’s revised RST and Eysenck’s PEN: distinguishing BIS and FFFS in Carver and White’s BIS/BAS scales

    OpenAIRE

    Heym, N; Ferguson, E; Lawrence, C

    2008-01-01

    Recent revisions of Gray's Reinforcement Sensitivity Theory (RST) have important implications for self-report measures of approach and avoidance behaviours and how Gray's model relates to other personality models. In this paper, we examine the revised RST by comparing Carver and White's (1994) original one-factor solution of the BIS scale with two alternative two-factor solutions separating BIS-Anxiety and FFFS-Fear. We also examine the relationships between Eysenck's PEN and revised RST fact...

  4. Review: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes (2008 Buchbesprechung: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes

    Directory of Open Access Journals (Sweden)

    Katrin Bromber

    2009-05-01

    Full Text Available Review of the monograph: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes, Stuttgart: Franz Steiner Verlag 2008, ISBN 978-3-515-09161-9, 359 pages. Besprechung der Monographie: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes, Stuttgart: Franz Steiner Verlag 2008, ISBN 978-3-515-09161-9, 359 Seiten.

  5. Biochemical and chemical characterization of trifluoromethylglyoxal bis(guanylhydrazone), a close analog of the antileukemic drug mitoguazone.

    Science.gov (United States)

    Elo, H; Mutikainen, I

    1988-01-01

    In order to study the structure-activity relationships of bis(guanylhydrazone) type polyamine antimetabolites, trifluoromethylglyoxal bis(guanylhydrazone) (CF3-GBG), a close analog of the antileukemic drug methylglyoxal bis(guanylhydrazone) (mitoguazone, MGBG) was synthesized according to a novel modification of previous methods, yielding single crystals. Single-crystal X-ray crystallography revealed the presence of an isomer different from the one detected in the case of MGBG and all other bis(guanylhydrazones) so far studied. In contrast to MGBG, CF3-GBG was shown to be a very weak inhibitor of yeast adenosylmethionine decarboxylase, being thus devoid of value as a polyamine antimetabolite. In addition, the compound did not have antiproliferative activity against mouse L1210 leukemia cells in vitro. As long as analogous isomers of the two compounds are not available, no conclusions can be drawn about the reasons lying behind the drastical differences between their biological properties.

  6. Acute Effects of Peripheral Injection of Bis-2-Chloro-ethyl sulfide on the Serum Proteins Content in Rat

    Directory of Open Access Journals (Sweden)

    DURDI QUJEQ

    1999-08-01

    Full Text Available Bis-2-chloroethyl sulfide or sulfur mustard an alkylating agent after absorption through skin may enter the blood circulation and interacts with different molecules in the body. Pulmonary complication, ocular lesions, enzyme disorders and other toxic effects of sulfur mustard in the body has already been reported. Rats were injected with sub-lethal doses of Bis-2-chloroethyl sulfide intraperitoneally and at different intervals serum was collected. The effect of Bis-2-chloroethyl sulfide on the relative proportion of th^ serum proteins was investigated using electrophoresis. Our results showed that peripheral injection of Bis-2-chloroethyl sulfide had effects on the aIpha-2-globulin and gamma-globulin content.

  7. Organonickel(II) complexes with anionic tridentate 1, 3-bis(azolylmethyl)phenyl ligands. synthesis, structural characterization and catalytic behavior

    Energy Technology Data Exchange (ETDEWEB)

    Hurtado, John; Rojas, Rene; Valderrama, Mauricio, E-mail: jmvalder@puc.cl [Departamento de Quimica Inorganica, Facultad de Quimica, Pontificia Universidad Catolica de Chile, Santiago (Chile); Ibanez, Andres [Centro para la Investigacion Interdisciplinaria Avanzada en Ciencia de los Materiales (CIMAT), Santiago (Chile); Froehlich, Roland [Organisch Chemisches Institut der Universitaet Muenster, Muenster (Germany)

    2011-09-15

    The reaction of 2-bromo-1,3-bis(bromomethyl)benzene with 3,5-dimethylpyrazole and {sup 1}H-indazole yields the tridentate ligands 2-bromo-1,3-bis(3,5-dimethylpirazol-1-ylmethyl)benzene (1) and 2-bromo-1,3-bis(indazol-2-ylmethyl)benzene (2). These compounds react with [Ni(cod)2] in tetrahydrofuran (thf) to form the oxidative addition complexes [NiBr{l_brace}1,3-bis(azolylmethyl)phenyl-N,C,N{r_brace}], azol 3,5-dimethylpyrazol (3), indazol (4), which were isolated in good yields as stable yellow solids and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), mass spectroscopy and nuclear magnetic resonance (NMR). In addition, the molecular structures of 2 and 4 were determined by single-crystal X-ray diffraction analysis. Complex 4 was tested as a catalyst in ethylene polymerization reaction. (author)

  8. [Prehn, Ulrich. Max Hildebert Boehm. Radikales Ordnungsdenken vom Ersten Weltkrieg bis in die Bundesrepublik] / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2015-01-01

    Arvustus: Prehn, Ulrich. Max Hildebert Boehm. Radikales Ordnungsdenken vom Ersten Weltkrieg bis in die Bundesrepublik (Hamburger Beiträge zur Sozizl- und Zeitgeschichte, 51). Wallstein Verlag. Göttingen 2013

  9. High pressure studies of superconductivity in BiO0.75F0.25BiS2

    Indian Academy of Sciences (India)

    20

    Hc1 decrease under external pressure P (0 ≤ P ≤ 1 GPa). We observe a decrease in critical current density and transition temperature on applying pressure in BiO0.75F0.25BiS2. Introduction. Crystal structure of the parent LnOBiS2 (Ln = La, Ce, Pr, Nd, Yb) consists of double. BiS2 layers stacked alternately with an Ln2O2 ...

  10. Preparation of 166 Dy/166 Ho DTPA-bis biotin as a system of In vivo generator

    International Nuclear Information System (INIS)

    Jimenez V, M.R.

    2003-01-01

    The objective of this work was to synthesize the complex 166 Dy/ 166 Ho - diethylen triamine pentaacetic-bis Biotin ( 166 Dy/ 166 Ho DTPA-bis Biotin) to evaluate its potential as a new radiopharmaceutical in directed radiotherapy. The Dysprosium-166 was obtained for neutron irradiation of 164 Dy 2 0 3 in the TRIGA Mark III reactor. The labelled was carried out in aqueous solution to p H 8.0 for addition of 166 Dy Cl 3 to the diethylen triamine pentaacetic-α, ω-bis Biotin (DTPA-bis Biotin). The radiochemical purity was determined for HPLC and ITLC. The biological integrity of the marked biotin is evaluated by the biological recognition of the avidin for HPLC - molecular exclusion with and without avidin addition. The studies of stability in vitro were made in dilutions of saline solution to 0.9% and with human serum at 37 C incubated 1 and 24 hours. The complex 166 Dy/ 166 Ho DTPA-bis Biotin was obtained with a radiochemical purity of 99.1 ± 0.6%. The biological recognition of the complex 166 Dy/ 166 Ho DTPA-bis Biotin for the avidin it doesn't affect the labelling procedure. The studies in vitro demonstrated that the 166 Dy/ 166 Ho DTPA-bis Biotin is stable after the dilution in saline solution and in human serum that there is not translocation of the one radionuclide subsequent son to the beta decay of the 166 Dy that could produce the 166 Ho 3+ liberation. The studies of Biodistribution in healthy mice demonstrated that the one complex 166 Dy/ 166 Ho DTPA-bis Biotin have a high renal distribution. In conclusion the radiolabelled biotin in this investigation has the appropriate properties to be used as an In vivo generator system stable for directed radiotherapy. (Author)

  11. Synthesis of Some New bis-Schiff Bases of Isatin and 5-Fluoroisatin in a Water Suspension Medium

    Directory of Open Access Journals (Sweden)

    D. Khalili

    2006-01-01

    Full Text Available Condensation of aromatic primary bis-amines with isatin (1H-indole-2,3-dione and 5-flouroisatin occurred cleanly and efficiently in a water suspension mediumwithout using any organic solvent or acid catalyst. The corresponding bis-Schiff baseswere obtained in good yields and were easily isolated by filtration. Their structures wereconfirmed by 1H-NMR, 13C-NMR, IR and mass spectra.

  12. Reactivity Studies of 2,6-Bis-(1,2,3-triazolyl)purine Nucleosides with Hydrazines and Amino Acids

    OpenAIRE

    Laķis, E; Novosjolova, I; Bizdēna, Ē; Turks, M

    2014-01-01

    Reactions of 2,6-bis-(1,2,3-triazolyl)purine nucleosides with nucleophiles is efficient route to C(6)-derivatization of purine base. To extend the field of application of the method, we studied reactivity of bis-(1,2,3-triazolyl)purine derivatives toward hydrazines and amino acids and obtained nucleosides substituted at C(6) with hydrazine and amino acid moieties.

  13. Psychometric Properties of Carver and White's (1994) BIS/BAS Scales in a Large Sample of Offenders

    OpenAIRE

    Poythress, Norman G.; Skeem, Jennifer L.; Weir, John; Lilienfeld, Scott O.; Douglas, Kevin S.; Edens, John F.; Kennealy, Patrick J.

    2008-01-01

    Contemporary motivational theories of psychopathy (Lykken, 1995) employ constructs from Gray's Reinforcement Sensitivity Theory (RST; Gray, 1982), behavioral inhibition system (BIS) and behavioral activation system (BAS) functioning, to explain etiologic differences in psychopathy subtypes. Carver and White's (1994) BIS/BAS scales are the most widely used measures of these constructs, yet there is a dearth of research on how these measures perform with offenders. Using a sample of 1,515 offen...

  14. Synthesis of palladium(0) and -(II) complexes with chelating bis(N-heterocyclic carbene) ligands and their application in semihydrogenation

    OpenAIRE

    Sluijter, S.N.; Warsink, S.; Lutz, M.; Elsevier, C.J.

    2013-01-01

    A transmetallation route, using silver(I) precursors, to several zero-and di-valent palladium complexes with chelating bis(N-heterocyclic carbene) ligands bearing various N-substituents has been established. The resulting complexes have been characterized by NMR and mass spectroscopy. In addition, the structure of a representative compound, [Pd-0(bis-(Mes)NHC)(eta(2)-ma)] (3a), was confirmed by X-ray crystal structure determination. In contrast to the transfer semihydrogenation, in which only...

  15. Side chain effect on electronic structure of spin-coated films of [6,6]-phenyl-C61-butyric acid methyl ester and its bis-adduct

    International Nuclear Information System (INIS)

    Akaike, Kouki; Kanai, Kaname; Ouchi, Yukio; Seki, Kazuhiko

    2013-01-01

    Highlights: ► Electronic structure of spin-coated films of PCBM and bis-PCBM was investigated. ► Ionization energy and electron affinity of bis-PCBM are smaller than those of PCBM. ► Electron donation from the side chain to C 60 -backbone raises the HOMO and LUMO. ► Open circuit voltages of PCBM-based solar cells relates to electron affinities. - Abstract: We investigated the electronic structure of spin-coated films of two soluble fullerenes; [6,6]-phenyl-C 61 -butyric acid methyl ester (PCBM) and its bis-adduct (bis-PCBM) using ultraviolet photoelectron spectroscopy, inverse photoemission spectroscopy and molecular orbital calculations. The ionization energy and electron affinity of spin-coated films of bis-PCBM were determined to be 6.01 eV and 3.4 eV, respectively. Analysis of electron density suggested the stronger electron donation from the two side chains to fullerene-backbone in a bis-PCBM molecule, compared with PCBM. The electron donation raises the energies of the frontier orbitals of bis-PCBM, which mainly consist of π-orbitals of fullerene-backbone. As a result, the ionization energy and electron affinity of bis-PCBM are smaller than those of PCBM. Moreover, we also concluded that the larger open circuit voltage observed for bis-PCBM based organic photovoltaics was explained by the higher-lying unoccupied molecular orbital of bis-PCBM

  16. Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology.

    Science.gov (United States)

    Lunagariya, Jignesh; Bhadja, Poonam; Zhong, Shenghui; Vekariya, Rohit; Xu, Shihai

    2017-09-27

    Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates. The alkaloids derived from marine resources play a crucial role in medicinal chemistry and as chemical agents. In particular, bis-indole alkaloid caulerpin isolated from marine green algae Caulerpa and a red algae Chondria armata at various places around the world, and tested against several therapeutic areas such as anti-diabetic, antinociceptive, anti-inflammatory, anti-tumor, anti-larvicidal, anti-herpes, anti-tubercular, anti-microbial and immunostimulating activity as well as means of other chemical agents. Herein, we summarized discovery of caulerpin, and its potential medicinal and chemical applications in chronological order with various aspects. Additionally, synthesis of caulerpin, its functional analogues, and structural isomer have also been reviewed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. Pharmacokinetic behaviour of phenylglyoxal bis(guanylhydrazone) (PGBG) after intravenous administration in rabbits.

    Science.gov (United States)

    Rodríguez, C; San Andrés, M I; San Andrés, M D; Encinas, T; González, F; Ballesteros, E

    2001-04-01

    Phenylglyoxal bis(guanylhydrazone) (PGBG) is a synthesized analogue of methylglyoxal bis(guanylhydrazone) (MGBG), which has demonstrated anti-parasitic activity in rabbits. The pharmacokinetic behaviour of PGBG after intravenous administration (10 mg/kg bodyweight) was studied in five rabbits. Plasma concentrations of PGBG were measured by high-performance liquid chromatography. Plasma PGBG concentrations decreased rapidly and were not detectable beyond 90 min after treatment. The mean [+/- standard deviation (SD)] volume of distribution at steady state (Vdss) was 2.19 +/- 0.47 l/kg and the mean plasma clearance value (Cl) was 29.99 +/- 3.98 ml/min kg. This drug is rapidly eliminated from the body in rabbits, having a short elimination half-life (0.93 h) and mean residence time (1.21 h).

  18. BIS-2 spectrometer for search and for investigation of narrow resonances

    International Nuclear Information System (INIS)

    Aleev, A.N.; Aref'ev, V.A.; Balandin, V.P.

    1991-01-01

    Configuration and main characteristics of the BIS-2 filmless spectrometer designed for search and study of charmed particles and narrow resonances generated in neutron-nuclear interactions are described. The spectrometer was arranged in neutral beam of the Serpukhov accelerator. Mean neutron energy is about 40 GeV. Main parts of the spectrometer are: spectrometric magnet, system of proportional chambers, system of charged particle identification, Cherenkov total-absorption spectrometer, system of scintillation counters, electronic equipment for event selection and data recording. The calculated and measured characteristics of separate parts and the system as a whole, as well as review of main results obtained by means of the BIS-2 spectrometer are given

  19. Fluorimetric determination of yttrium by methyl-bis(8-hydraxy--- 2-quinolyl)amine

    International Nuclear Information System (INIS)

    Golovina, A.P.; Kachin, S.V.; Runov, V.K.; Fakeeva, O.A.

    1982-01-01

    Using a method of mathematical Box-Wilson experiment planning the optimum conditions of yttrium fluorimetric determination by methyl-bis (8-hydroxy-2-quinolyl) amine (pH 7.5, csub(R)=1.4x10sup(-5) M) with the determination limit=0.05 μg/ml are found. An extraction-fluorimetric method of yttrium determination by methyl-bis (8-hydroxy-2-quinolyl) amine is developed. The extraction has been realized with aliphatic alcohols at pH > 11. The method is characteristic of the lowest determination limit (0.01 μg/ml) as compared with the known ones. The possibility is shown of yttrium determination in the presence of 5000-multiple aluminium contents, stoichiometric contents of La, Lu, Fe (3), U (6), tartrates, citrates

  20. Bis-spirochromanones as potent inhibitors of Mycobacterium tuberculosis: synthesis and biological evaluation.

    Science.gov (United States)

    Dongamanti, Ashok; Aamate, Vikas Kumar; Devulapally, Mohan Gandhi; Gundu, Srinivas; Balabadra, Saikrishna; Manga, Vijjulatha; Yogeeswari, Perumal; Sriram, Dharmarajan; Balasubramanian, Sridhar

    2017-11-01

    On the basis of reported antimycobacterial property of chroman-4-one pharmacophore, a series of chemically modified bis-spirochromanones were synthesized starting from 2-hydroxyacetophenone and 1,4-dioxaspiro[4.5] decan-8-one using a Kabbe condensation approach. The synthesized bis-spirochromanones were established based on their spectral data and X-ray crystal structure of 6e. All synthesized compounds were evaluated against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain, finding that some products exhibited good antimycobacterial activity with minimum inhibitory concentration as low as [Formula: see text]. Docking studies were carried out to identify the binding interactions of compounds II, 6a and 6n with FtsZ. Compounds exhibiting good in vitro potency in the MTB MIC assay were further evaluated for toxicity using the HEK cell line.

  1. A Gas Leak Rate Measurement System for the ATLAS MUON BIS-Monitored Drift Tubes

    CERN Document Server

    Alexopoulos, T; Dris, M; Filippas-Tassos, A; Gazis, E N; Katsoufis, E C; Maltezos, S; Savva, Panagiota S; Stavropoulos, G D; Tsipolitis, G

    2004-01-01

    A low-cost, reliable and precise system developed for the gas leak rate measurement of the BIS-Monitored Drift Tubes (MDTs) for the ATLAS Muon Spectrometer is presented. In order to meet the BIS-MDT mass production rate, a total number of 100 tubes are tested simultaneously in this setup. The pressure drop of each one of the MDT is measured, within a typical time interval of 48 hours, via a differential manometer comparing with the pressure of a gas tight reference tube. The precision of the method implemented is based on the system temperature homogeneity, with accuracy of ÄT = 0.3 oC. For this reason, two thermally isolated boxes are used testing 50 tubes each of them, to achieve high degree of temperature uniformity and stability. After measuring several thousands of the MDTs, the developed system is confirmed to be appropriate within the specifications for testing the MDTs during the mass production.

  2. Ethylene oligomerization using iron complexes: beyond the discovery of bis(imino)pyridine ligands.

    Science.gov (United States)

    Boudier, Adrien; Breuil, Pierre-Alain R; Magna, Lionel; Olivier-Bourbigou, Hélène; Braunstein, Pierre

    2014-02-11

    Since the discovery that bis(imino)pyridine ligands are able to confer high activities in ethylene oligomerization and polymerization to their iron complexes, considerable attention has been focused on catalyst design for these reactions and this research constitutes an ever-growing area in molecular catalysis. The tuning of the ligand structures and properties, and thus of catalysts, generally represents the basis for subsequent work contributing to process development and industrialization. Significant effort is therefore devoted to generate structural diversity in order to access the required catalyst stability and selectivity. This feature article outlines nitrogen-containing ligands that have been developed for the iron-catalyzed oligomerization of ethylene since the seminal discovery of the properties of bis(imino)pyridine ligands.

  3. Effects of polyamines and methylglyoxal bis(guanylhydrazone) on hepatic nuclear structure and deoxyribonucleic acid template activity.

    Science.gov (United States)

    Brown, K B; Nelson, N F; Brown, D G

    1975-12-01

    1. The interaction of polyamines and methylglyoxal bis(guanythydrazone) (1, 1'-[(methylethanediylidene)-dinitrilo]diguanidine) with isolated rat liver nuclei was investigated by electron microscopy. 2. At 4mM, putrescine was without effect; however, spermidine, spermine or methylglyoxal bis(guanythydrazone) resulted in dispersed chromatin and alterations in nucleolar structure. In addition, spermidine or methylglyoxal bis(guanylhydrazone) caused marked aggregation of interchromatin granules. 3. The DNA template property of calf thymus DNA was examined by using DNA polymerases from Escherichia coli, Micrococcus lysodeikticus and calf thymus in the presence of 0-5 mM-amine. 4. In the presence of DNA polymerase, spermine or methylglyoxal bis(guanylhydrazone) inhibited activity, whereas putrescine or spermidine had much less effect or in some cases stimulated [3H]dTMP incorporation. 5. Template activity which was inhibited by spermine or methylglyoxal bis(guanylhydrazone) could be partially restored by additional DNA or enzyme. 6. When mixed with calf thymus DNA, calf thymus histone inhibited template activity as measured with E. coli DNA polymerase. The template activity of such a 'histone-nucleate' could not be restored by putrescine, spermidine, spermine or methylglyoxal bis(guanylhydrazone). 7. DNA template activity of isolated rat liver nuclei was tested by using E. coli DNA polymerase. None of the amines was able to increase the template activity of the nuclear DNA in vitro.

  4. A novel fluorescent probe (dtpa-bis(cytosine)) for detection of Eu(III) in rare earth metal ions

    Science.gov (United States)

    Yang, Fan; Ren, Peipei; Liu, Guanhong; Song, Youtao; Bu, Naishun; Wang, Jun

    2018-03-01

    In this paper, a novel fluorescent probe, dtpa-bis(cytosine), was designed and synthesized for detecting europium (Eu3 +) ion. Upon addition of Eu3 + ions into the dtpa-bis(cytosine) solution, the fluorescence intensity can strongly be enhanced. Conversely, adding other rare earth metal ions, such as Y3 +, Ce3 +, Pr3 +, Nd3 +, Sm3 +, Gd3 +, Tb3 +, Dy3 +, Ho3 +, Er3 +, Yb3 + and Lu3 +, into dtpa-bis(cytosine) solution, the fluorescence intensity is decreased slightly. Some parameters affecting the fluorescence intensity of dtpa-bis(cytosine) solution in the presence of Eu3 + ions were investigated, including solution pH value, Eu3 + ion concentration and interfering substances. The detection mechanism of Eu3 + ion using dtpa-bis(cytosine) as fluorescent probe was proposed. Under optimum conditions, the fluorescence emission intensities of EuIII-dtpa-bis(cytosine) at 375 nm in the concentration range of 0.50 × 10- 5 mol • L- 1-5.00 × 10- 5 mol • L- 1 of Eu3 + ion display a better linear relationship. The limit of detection (LOD) was determined as 8.65 × 10- 7 mol • L- 1 and the corresponding correlation coefficient (R2) of the linear equation is 0.9807. It is wished that the proposed method could be applied for sensitively and selectively detecting Eu3 + ion.

  5. Mapping Gray's BIS and BAS Constructs onto Factor 1 and Factor 2 of Hare's Psychopathy Checklist - Revised.

    Science.gov (United States)

    Wallace, John F; Malterer, Melanie B; Newman, Joseph P

    2009-12-01

    Reinforcement Sensitivity Theory (RST; Gray, 1987; Gray & McNaughton, 2000) has proven to be a valuable tool for understanding psychopathy (e.g., Fowles, 1980, 1988; Newman & Malterer, 2009; Poythress, Edens, Landfield, Lilienfeld, Skeem, & Douglas, 2008). Recent research has linked two RST constructs, the Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS), to individuals with primary psychopathy and secondary psychopathy (Lykken, 1995; Newman, MacCoon, Vaughn, & Sadeh, 2005): Primary psychopaths manifest low BIS reactivity and secondary psychopaths manifest high BAS reactivity. In the present study, we examine the relationships between the BIS/BAS constructs and Factors 1 and 2 of the Psychopathy Checklist - Revised (PCL-R) in a sample of 472 incarcerated male offenders. Paralleling their relationships with primary and secondary psychopathy, the BIS/BAS constructs were differentially related to the two PCL-R factors. Specifically, the influence of the BIS was found to be more prominent than the influence of the BAS for Factor 1, and the influence of the BAS was more prominent than that of the BIS for Factor 2.

  6. Effects of Zinc Deuteroporphyrin Bis Glycol on Newborn Mice After Heme-Loading

    OpenAIRE

    He, Cynthia X.; Campbell, Claire M.; Zhao, Hui; Kalish, Flora S.; Schulz, Stephanie; Vreman, Hendrik J.; Wong, Ronald J.; Stevenson, David K.

    2011-01-01

    Infants with hemolytic diseases frequently develop hyperbilirubinemia, but standard phototherapy only eliminates bilirubin after its production. A better strategy might be to directly inhibit heme oxygenase (HO), the rate-limiting enzyme in bilirubin production. Metalloporphyrins (Mps) are heme analogs that competitively inhibit HO activity in vitro and in vivo and suppress plasma bilirubin levels in vivo. A promising Mp, zinc deuteroporphyrin bis glycol (ZnBG), is orally absorbed and effecti...

  7. Kurz- bis mittelfristige Ergebnisse der Druckscheibenendoprothese in der Behandlung der Femurkopfnekrose

    OpenAIRE

    Käsemann, Bertram

    2007-01-01

    In der vorliegenden klinischen Studie wurden 45 implantierte Druckscheibenendoprothesen von 39 Patienten, die ab dem Stadium ARCO II an einer Femurkopfnekrose erkrankt waren, zwischen Mai 1994 bis April 1999 beobachtet. Die mittlere Nachuntersuchungszeit belief sich, bei einer Spanne von 2-57 Monaten, auf 21,2 Monaten. Das durchschnittliche Follow-up betrug 3,1 Jahre. Im Vorfeld der Untersuchung erfolgte eine eigene Einteilung der Osteonekroseausbreitung im Stadium I-IV der röntgologischen- u...

  8. 4,4’-Bis(4-octylphenoxy-2,2’-bipyridine

    Directory of Open Access Journals (Sweden)

    Zhen-Ting Du

    2009-12-01

    Full Text Available 4,4’-Bis(4-octylphenoxy-2,2’-bipyridine which can be used in complexes of ruthenium was synthesized. This ligand bears a long chain for the purpose of increasing the solubility of the final complex. The synthesis was achieved through a nucleophilic aromatic substitution reaction of 4,4’-bromo-2,2’-bipyridine and 4-octylphenol.

  9. 4,4’-Bis(4-octylphenoxy)-2,2’-bipyridine

    OpenAIRE

    Zhen-Ting Du; Jun-Ru Wang; Ru Liu; Yan Xu

    2009-01-01

    4,4’-Bis(4-octylphenoxy)-2,2’-bipyridine which can be used in complexes of ruthenium was synthesized. This ligand bears a long chain for the purpose of increasing the solubility of the final complex. The synthesis was achieved through a nucleophilic aromatic substitution reaction of 4,4’-bromo-2,2’-bipyridine and 4-octylphenol.

  10. An efficient and facile synthesis of divergent C-3/C-5 bis ...

    Indian Academy of Sciences (India)

    combined moderate-to-good yield (54–75%). 2.3 Procedure for the isomerization of Bromide nucleophile. A mixture of bis-MBH adduct of oxindole 3b (50 mg,. 0.152 mmol), 46% aqua. HBr (2 equiv.) and silica gel. (0.2g) are made a slurry. The slurry was subjected to microwave irradiation (70% power level, 5sec. pulse,.

  11. Ambient-temperature superconductor symetrical metal-dihalide bis-(ethylenedithio)-tetrathiafulvalene compounds

    Science.gov (United States)

    Williams, Jack M.; Wang, Hsien-Hau; Beno, Mark A.

    1987-01-01

    A new class of organic superconductors having the formula (ET).sub.2 MX.sub.2 wherein ET represents bis(ethylenedithio)-tetrathiafulvalene, M is a metal such as Au, Ag, In, Tl, Rb, Pd and the like and X is a halide. The superconductor (ET).sub.2 AuI.sub.2 exhibits a transition temperature of 5 K. which is high for organic superconductors.

  12. 1,1,1-Trichloro-2,2-bis(4-iodophenylethane

    Directory of Open Access Journals (Sweden)

    Graham Smith

    2012-08-01

    Full Text Available In the structure of the title compound, C14H9Cl3I2, which is the 4-iodophenyl analogue of the insecticide DDT [1,1,1-trichloro-2,2-bis(4-chlorophenylethane], isomorphism between the two compounds has been confirmed. In the molecule, the dihedral angle between the planes of the two benzene rings is 65.8 (4° which compares with 64.7 (7° in DDT.

  13. Convenient synthesis of [2-14C]-methylglyoxal bis(guanylhydrazone), [14C]-mitoguazone

    International Nuclear Information System (INIS)

    Burgos, A.; Ellames, G.J.

    1995-01-01

    [2- 14 C]-Methylglyoxal bis(guanylhydrazone) dihydrochloride, [ 14 C]-mitoguazone has been prepared in three steps from potassium[1- 14 C]-acetate in an overall radiochemical yield of 16%. The key steps in this procedure are the formation of the sodium salt of[acetone-2- 14 C]-methylsulfinylacetone, and Pummerer rearrangement to the [ 14 C] labelled hermithioacetal, which is trapped with two equivalents of aminoguanidine to afford the desired [ 14 C]-mitoguazone. (Author)

  14. Relation of the antiproliferative action of methylglyoxal-bis(guanylhydrazone) to the natural polyamines.

    Science.gov (United States)

    Seppänen, P; Alhonen-Hongisto, L; Jänne, J

    1980-09-01

    Enzymic determinations of intracellular concentrations of methylglyoxal-bis(guanylhydrazone), an anticancer drug which inhibits the synthesis of the polyamines spermidine and spermine, in cultured tumor cells revealed that the drug was remarkably effectively concentrated inside the cell. A concentration gradient across the cell membrane as great as 500--1000-fold was formed in cells exposed to the drug for 1-2 days. An exposure of cultured Ehrlich ascites carcinoma cells to increasing concentrations of the drug indicated that the cells could tolerate intracellular concentrations up to 1 mM with only slight changes in their proliferation rate. Micromolar concentrations of spermidine or spermine, but not putrescine, effectively blocked the uptake of methylglyoxal-bis(guanylhydrazone) and reduced the intracellular concentration of the drug below the levels required for growth inhibition. Analysis of cellular polyamine contents in Ehrlich ascites cells exposed to rising concentrations of methylglyoxal-bis(guanylhydrazone) gave little support to the view that the drug-induced growth inhibition was solely produced by an intracellular polyamine deprivation. Not only was the uptake of the drug inhibited in the presence of spermidine and spermine, but it was likewise washed out by polyamines from the cells that had been previously exposed to the drug and then transferred into drug-free medium in the presence of polyamines. For the inhibition of methylglyoxal-bis(guanylhydrazone) uptake by amines, three or more amino/imino groups were apparently required, since low concentrations of aliphatic diamines were either without any effect (short-chain diamines) or only marginally prevented (long-chain diamines) the uptake of the drug. High concentrations of Mg2+ ions, however, markedly inhibited the transport of the drug into Ehrlich ascites tumor cells.

  15. Helically labile bis(haloBODIPYs): an advantageous platform for the development of CPL-SOMs

    OpenAIRE

    Ray, C��sar; S��nchez-Carnerero, Esther M.; Moreno, Florencio; Maroto, Beatriz L.; Agarrabeitia, Antonia R.; Ortiz, Mar��a J.; L��pez-Arbeloa, ����igo; Ba��uelos, Jorge; Cohovi, Komlan D.; Lunkley, Jamie L.; Muller, Gilles; de la Moya, Santiago

    2016-01-01

    Simple organic molecules (SOM) based on bis(haloBODIPY) are shown to enable circularly polarized luminescence (CPL), giving rise to a new structural design for technologically valuable CPL-SOMs. The established design comprises together synthetic accessibility, labile helicity, possibility of reversing the handedness of the circularly polarized emission, and reactive functional groups, making it unique and attractive as advantageous platform for the development of smart CPL-SOMs.

  16. {2,6-Bis[(di-tert-butyl-phosphino)-methyl]-phenyl}chloridonickel(II).

    Science.gov (United States)

    Boro, Brian J; Dickie, Diane A; Goldberg, Karen I; Kemp, Richard A

    2008-09-20

    In the title compound, [Ni(C(24)H(43)P(2))Cl], the Ni atom adopts a distorted square-planar geometry, with the P atoms of the 2,6-bis-[(di-tert-butyl-phosphino)meth-yl]phenyl ligand trans to one another. The P-Ni-P plane is twisted out of the plane of the aromatic ring by 21.97 (6)°.

  17. HyBIS - a low cost, multi-purpose, modular vehicle for detailed ocean mapping

    Science.gov (United States)

    Huehnerbach, V.; Murton, B.; Berndt, C.; Garrard, J.; Wollatz-Vogt, M.; Wetzel, G.; Matthiessen, T.

    2013-12-01

    HyBIS is a low-cost, multi-purpose, highly maneuverable, fibre-optic controlled survey and sampling robotic underwater vehicle (RUV) capable of diving to 6000m. Built in the UK by Hydro-Lek Ltd. in collaboration with the National Oceanography Centre, Southampton, it has proven itself during recent discoveries of the deepest hydrothermal vents in the world, at 5100m deep in the Cayman Trough in the Caribbean and habitat mapping of seamounts in the Atlantic and Indian oceans . The vehicle has a modular design, with the top module being a command and power system that comprises power management, cameras, lights, hydraulics, thrusters and telemetry. The lower module can alternatively be a clam-shell sampling grab, a manipulator-arm and tool sled, a winch for instrument recovery, or an ocean bottom seismometer deployment module. Unlike a conventional ROV, HyBIS does not have any floatation, rather it is suspended by its umbilical cable directly from the ship. The advantage of direct suspension is that HyBIS can recover or deploy a payload of up to 700kg, although this comes at the price of reduced maneuverability compared to a 'normal' ROV. During its four years of service, HyBIS has, so far, accumulated an impressive list of achievements: recording over 450 hours of HD video footage, thousands of HD still images, collected geological, biological samples, as well as fluids and gas from over 40 different sites. It has also recovered two different seabed landers containing scientific equipment worth over £300k, and placed Ocean Bottom Seismometers onto the seafloor.

  18. Monitoring sleep depth: analysis of bispectral index (BIS) based on polysomnographic recordings and sleep deprivation

    OpenAIRE

    Giménez Badia, Sandra; Romero Lafuente, Sergio; Alonso López, Joan Francesc; Mañanas Villanueva, Miguel Ángel; Pujol, Anna; Baxarias, Pilar; Antonijoan Arbós, Rosa Maria

    2015-01-01

    © 2015 Springer Science+Business Media Dordrecht The assessment and management of sleep are increasingly recommended in the clinical practice. Polysomnography (PSG) is considered the gold standard test to monitor sleep objectively, but some practical and technical constraints exist due to environmental and patient considerations. Bispectral index (BIS) monitoring is commonly used in clinical practice for guiding anesthetic administration and provides an index based on relationships between...

  19. Facile Synthesis of Bis(indolylmethanes Catalyzed by α-Chymotrypsin

    Directory of Open Access Journals (Sweden)

    Zong-Bo Xie

    2014-11-01

    Full Text Available A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolylmethanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95% using a little α-chymotrypsin as catalyst.

  20. Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

    OpenAIRE

    Xie, Zong-Bo; Sun, Da-Zhao; Jiang, Guo-Fang; Le, Zhang-Gao

    2014-01-01

    A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.

  1. Facile synthesis of bis(indolyl)methanes catalyzed by α-chymotrypsin.

    Science.gov (United States)

    Xie, Zong-Bo; Sun, Da-Zhao; Jiang, Guo-Fang; Le, Zhang-Gao

    2014-11-27

    A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst.

  2. Bis(quercetinato)oxovanadium IV Reverses Metabolic Changes in Streptozotocin-Induced Diabetic Mice

    OpenAIRE

    Shukla, Ruchi; Padhye, Subhash; Modak, Manisha; Ghaskadbi, Saroj S.; Bhonde, Ramesh R.

    2007-01-01

    Organic vanadium compounds offer several advantages in the treatment of diabetes, yet they are impractical to use because of known side effects. In order to ameliorate the side effects of vanadium, we conjugated it with quercetin to form bis(quercetinato)oxovanadium IV (BQOV). This study evaluates the effect of BQOV treatment on carbohydrate metabolism and overall oxidative stress in streptozotocin-induced (STZ) diabetic mice. Administration of BQOV orally to diabetic mice for 3 weeks led to ...

  3. Crystal Structure of N,N-bis-(3-Carbomethoxy-5-methyl-pyrazol-1-ylmethylaniline

    Directory of Open Access Journals (Sweden)

    Taibi Ben-Hadda

    2002-09-01

    Full Text Available The tripodal ligand N,N-bis-(3-carbomethoxy-5-methylpyrazol-1-ylmethyl aniline (2 has been prepared by the condensation of aniline with two equivalents of N-hydroxymethyl[3-carbomethoxy-5-methyl]pyrazole. The molecule consists of two structurally analogous 3-carbomethoxy-5-methylpyrazol-1-ylmethyl moieties, which adopt a transoidal conformation via a central aniline ring, suggesting that this tripodal ligand is highly flexible and could accommodate many metals by coordination.

  4. An efficient synthesis of symmetric and unsymmetric bis-(β-aminoamides) via Ugi multicomponent reaction.

    Science.gov (United States)

    La Spisa, Fabio; Feo, Alberto; Mossetti, Riccardo; Tron, Gian Cesare

    2012-12-07

    A library of symmetrical and unsymmetrical bis-(β-aminoamides) has been prepared starting from symmetrical secondary diamines by using a double Ugi four-component reaction. A sacrifical Mumm rearrangement, thanks to the use of 2-hydroxymethyl benzoic acid, is necessary to suppress the competing split-Ugi reaction, increasing the yield and simplifying the purification step. The scope, the reaction conditions, and the role of water in trapping the nitrilium intermediate are also discussed.

  5. Nootropic effects of bis(citrato)germanates (stannates) with different metals (Mg, Co) in their structure

    OpenAIRE

    V. V. Godovan; M. V. Matyushkina; R. S. Vastyanov

    2014-01-01

    Aim. Nootropic effects of bis(citrato)germanates (stannates) with different metals (Mg, Co) have been investigated in this article. With this aim the peculiarities of conditioned reflex formation as well as short- and long-term memory manifestations under the influence of the investigated coordinative compounds have been studied for 256 rats with the help of pathophysiological and pharmacological methods. Methods and results. It has been shown that stannates influence on the development o...

  6. A systematic review of the measurement properties of the Body Image Scale (BIS) in cancer patients.

    Science.gov (United States)

    Melissant, Heleen C; Neijenhuijs, Koen I; Jansen, Femke; Aaronson, Neil K; Groenvold, Mogens; Holzner, Bernhard; Terwee, Caroline B; van Uden-Kraan, Cornelia F; Cuijpers, Pim; Verdonck-de Leeuw, Irma M

    2018-03-12

    Body image is acknowledged as an important aspect of health-related quality of life in cancer patients. The Body Image Scale (BIS) is a patient-reported outcome measure (PROM) to evaluate body image in cancer patients. The aim of this study was to systematically review measurement properties of the BIS among cancer patients. A search in Embase, MEDLINE, PsycINFO, and Web of Science was performed to identify studies that investigated measurement properties of the BIS (Prospero ID 42017057237). Study quality was assessed (excellent, good, fair, poor), and data were extracted and analyzed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on structural validity, internal consistency, reliability, measurement error, hypothesis testing for construct validity, and responsiveness. Evidence was categorized into sufficient, insufficient, inconsistent, or indeterminate. Nine studies were included. Evidence was sufficient for structural validity (one factor solution), internal consistency (α = 0.86-0.96), and reliability (r > 0.70); indeterminate for measurement error (information on minimal important change lacked) and responsiveness (increasing body image disturbance in only one study); and inconsistent for hypothesis testing (conflicting results). Quality of the evidence was moderate to low. No studies reported on cross-cultural validity. The BIS is a PROM with good structural validity, internal consistency, and test-retest reliability, but good quality studies on the other measurement properties are needed to optimize evidence. It is recommended to include a wider variety of cancer diagnoses and treatment modalities in these future studies.

  7. Methanofullerene-Based Palladium Bis(amino)aryl Complexes and Applications in Lewis Acid Catalysis

    NARCIS (Netherlands)

    Koten, G. van; Meijer, M.D.; Ronde, N.; Vogt, D.; Klink, G.P.M. van

    2001-01-01

    Synthetic routes have been developed for the attachment of palladium(II) bis(amino)aryl (NCN or C6H2{CH2NMe2}2-2,6)- complexes to C60. Using diazo and Bingel addition reactions, various methanofullerene NCN-SiMe3 compounds (C60-L-NCN-SiMe3, L = C(Me), C(CO2Et)CO2CH2, and C(Me)C6H4CC) have been

  8. Ne Bis In Idem: Towards a Transnational Constitutional Principle in the EU?

    Directory of Open Access Journals (Sweden)

    John A.E. Vervaele

    2013-09-01

    Full Text Available Citizens and companies globalize: they are increasingly making use of their rights to free movement, to free settlement, to offer services and goods, to realize financial transactions, etc. Enforcement systems, including the criminal justice system, have to follow suit. They are obliged to go abroad to gather evidence, for the detention and extradition or surrender of suspects, to confiscate assets, to deal with conflicts of jurisdiction and the choice of allocating a criminal investigation and adjudication. Globalizing criminal justice systems increases the risk of double prosecution and/or double punishment. Do (legal persons have the (fundamental right not to be prosecuted or punished twice for the same facts in a globalizing and integrating world. Are they protected against these forms of double jeopardy in settings of transnational criminal justice, such as for instance in the EU area of freedom, security and justice? Does the ne bis in idem principle have a transnational reach? If so, what does this mean and what are the obstacles and exceptions thereto? In posing these questions, this article asks whether a (legal person can derive a right to transnational protection in the area of freedom, security and justice from the different sources of ne bis in idem obligations in domestic law, in public international law (human rights law and mutual legal assistance and in EU law. By analysing these sources and the case law thereon, I come to the conclusion that (legal persons are unprotected against transnational double jeopardy, with the exception of the transnational ne bis in idem in the EU area of freedom, security and justice. However, even in the case of the latter exceptions, derogations, reservations and draw back interpretations based on national sovereignty undermine the rationale and scope of a real transnational ne bis in idem principle in a common space of transnational criminal justice.

  9. 1,1′-{(Hexane-1,6-diylbis[(azaniumylylidenemethanylylidene]}bis(naphthalen-2-olate

    Directory of Open Access Journals (Sweden)

    Kamel Ouari

    2015-01-01

    Full Text Available The whole molecule of the title Schiff base compound, C28H28N2O2, is generated by inversion symmetry. It is formed from two units of ortho-hydroxynaphthaldehyde bridged with 1,6-diaminohexane. The N atoms are protonated and, thus, the structure is a bis-zwitterionic compound in the solid state. The zwitterion shows strong intramolecular N—H...O hydrogen bonds between the iminium N and the naphthalenolate O atoms.

  10. Ne2 encodes protein(s) and the altered RuBisCO could be the ...

    Indian Academy of Sciences (India)

    Si Rui Pan

    2017-06-17

    Jun 17, 2017 ... [Pan S. R., Pan X. L., Pan Q. Y., Shi Y. H., Zhang L., Fan Y. and Xue Y. R. 2017 Ne2 encodes protein(s) and the altered RuBisCO could be the proteomics leader of hybrid necrosis in wheat (Triticum aestivum L.). J. Genet. 96, 261–271]. Introduction. The world is facing the challenge of producing more wheat.

  11. Lithium bis(fluorosulfonyl)imide-PYR14TFSI ionic liquid electrolyte compatible with graphite

    Czech Academy of Sciences Publication Activity Database

    Nádherná, Martina; Reiter, Jakub; Moškon, J.; Dominko, R.

    2011-01-01

    Roč. 196, č. 18 (2011), s. 7700-7706 ISSN 0378-7753 R&D Projects: GA AV ČR(CZ) KJB200320801; GA AV ČR KJB200320901; GA MŠk(CZ) LC523 Institutional research plan: CEZ:AV0Z40320502 Keywords : Graphite * Ionic liquid * Bis(fluorosulfonyl)imide * Lithium-ion battery * Solid electrolyte interface Subject RIV: CA - Inorganic Chemistry OBOR OECD: Inorganic and nuclear chemistry Impact factor: 4.951, year: 2011

  12. Comparison of specificity of inhibition of polyamine synthesis in bovine lymphocytes by ethylglyoxal bis(guanylhydrazone) and methylglyoxal bis(guanylhydrazone).

    Science.gov (United States)

    Igarashi, K; Porter, C W; Morris, D R

    1984-11-01

    Ethylglyoxal bis(guanylhydrazone) (EGBG) was compared as an inhibitor of polyamine biosynthesis with methylglyoxal bis(guanylhydrazone) (MGBG) in bovine small lymphocytes stimulated by concanavalin A. EGBG brought about a decrease in spermidine and spermine levels equal to that found with MGBG, but at a 5-fold lower intracellular drug concentration. Despite identical polyamine levels, the degree of inhibition of DNA and protein synthesis by EGBG was smaller than that observed with MGBG, in either the presence or absence of the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine. It was found that in vitro protein synthesis and in vivo mitochondrial function were inhibited by concentrations of MGBG necessary to inhibit polyamine synthesis in cells (1 to 3 mM), but not by efficacious levels of EGBG (0.2 to 0.6 mM). These results suggest that EGBG is more suitable as a specific inhibitor of polyamine biosynthesis and that use of this drug, rather than MGBG, in combination with alpha-difluoromethylornithine may be useful for studying the physiological functions of polyamines in animal cells.

  13. [N,N′-Bis(2,6-diisopropylphenylmethanimidamidato][η8-1,4-bis(trimethylsilylcyclooctatetraenyl](tetrahydrofuransamarium(III toluene monosolvate

    Directory of Open Access Journals (Sweden)

    Anja Edelmann

    2010-12-01

    Full Text Available The title compound, [Sm(C25H35N2(C14H24Si2(C4H8O]·C7H8, was prepared by treatment of anhydrous samarium trichloride with a 1:1 mixture of in situ-prepared Li(DippForm [DippFormH = N,N′-bis(2,6-diisopropylphenylmethanimidamide] and Li2(COT′′ [COT′′ = 1,4-bis(trimethylsilylcyclooctatetraenyl] in tetrahydrofuran (THF. Despite the presence of two very bulky ligands (COT′′ and DippForm, the molecule still contains one coordinated THF ligand. The overall coordination geometry around the SmIII atom resembles a three-legged piano-stool with the COT′′ ligand being η8-coordinated and the DippForm− anion acting as an N,N′-chelating ligand [Sm—N = 2.5555 (15 and 2.4699 (15 Å]. The asymmetric unit also contains a disordered molecule of toluene, the refined ratio of the two components being 0.80 (4:0.20 (4.

  14. Synthesis and Structure of a Binuclear Cu(II Complex of 1,3- bis [N,N-bis(2-picolylamino]propan-2-ol

    Directory of Open Access Journals (Sweden)

    Ray Butcher

    2006-06-01

    Full Text Available The synthesis and crystal structure of Cu(II complex of a binucleating tridentateligand 1,3-bis [N,N-bis(2-picolylamino]propan-2-ol (I is being reported. The two chelatingbispicolylamine arms in I are tethered by a 2-hydroxypropyl group with Cu(II coordinatingin a slightly distorted square planar geometry to give [Cu2(I(OH2(Cl](ClO43·2H2O (II.The crystal data for II: Triclinic, space group Pī with cell dimensions of a = 13.345 (4 å,b = 13.873 (4 å, c = 12.867 (2 å, α = 111.68 (2°, β = 100.34 (2°, γ = 65.83 (2°, V =2018.4 (9 å3, F.W. = 962.46, ρcalc = 1.583 g cm-3 for Z = 2, μ = 13.93 cm-1

  15. Impregnation of chelating agent 3,3-bis-N,N bis-(carboxymethylaminomethyl-o-cresolsulfonephthalein in biopolymer chitosan: adsorption equilibrium of Cu(II in aqueous medium

    Directory of Open Access Journals (Sweden)

    Luciano Vitali

    2006-06-01

    Full Text Available The aim of this study was to impregnate the chelating agent 3,3-bis-N,N,bis-(carboxymethylaminomethyl-o-cresolsulfonephthalein in chitosan and to investigate the adsorption of Cu(II ions. The chemical modification was confirmed by FTIR spectrometry, thermogravimetric analysis (TGA and energy dispersive x-ray spectroscopy (EDX. The adsorption studies were carried out with Cu(II ions in a batch process and were shown to be dependent on pH. The adsorption kinetics was tested using three models: pseudo first-order, pseudo second order and intraparticle diffusion. The experimental kinetics data were best fitted with the pseudo second-order model (R² = 0.999, which provided a rate constant, k2, of 1.21 x 10-3 g mg-1 min-1. The adsorption rate depended on the concentration of Cu(II ions on the adsorbent surface and on the quantity of Cu(II ions adsorbed at equilibrium. The Langmuir isotherm model provided the best fit for the equilibrium data in the concentration range investigated, with the maximum adsorption capacity being 81.0 mg of Cu(II per gram of adsorbent, as obtained from the linear equation of the isotherm. Desorption tests revealed that around 90% of the adsorbed metal was removed, using EDTA solution as the eluent. This result suggests that the polymeric matrix can be reused.

  16. Mechanism of photoluminescence quenching in thin films of N,N'-bis(3-methylphenyl-N,N'-bis(phenylbenzidine irradiated by UV light in air

    Directory of Open Access Journals (Sweden)

    Tomović Aleksandar Ž.

    2015-01-01

    Full Text Available The mechanism of photoluminescence (PL quenching of thin amorphous N,N'-bis(3-methylphenyl- N,N'-bis(phenylbenzidine (TPD films exposed to UV light in air is studied. TPD is small organic molecule widely used in production of organic light emmiting devices (OLEDs. Photoluminescence of TPD films decays exponentially with time of irradiation, i.e. with the increase of concentration of impurities (photo-oxidized TPD molecules generated by UV irradiation in air. Intensity of PL decreases to half of its original value when the concentration of impurities reaches 0.4%. Average distance between impurities (acceptors is almost an order of magnitude larger than average distance between host TPD molecules (donors. Direct long range Forster energy transfer is ruled out as the mechanism of PL quenching, as the overlap between donor and acceptor is lacking, and exciton self-diffusion in TPD films is postulated for the mechanism. The presence of oxidation products is confirmed by infrared (IR spectroscopy. Vibrational spectra of TPD molecule and few other possible products of photo-oxidation of TPD molecule, obtained by density functional theory, are compared to experimental IR spectra.

  17. Bis(formylphenolatocobalt(II-Mediated Alternating Radical Copolymerization of tert-Butyl 2-Trifluoromethylacrylate with Vinyl Acetate

    Directory of Open Access Journals (Sweden)

    Sanjib Banerjee

    2017-12-01

    Full Text Available The organometallic-mediated radical polymerization (OMRP of vinyl acetate (VAc and its OMR copolymerization (OMRcoP with tert-butyl 2-trifluoromethylacrylate (MAF-TBE mediated by Co(SAL2 (SAL = 2-formylphenolato or deprotonated salicylaldehyde produced relatively well-defined PVAc and poly(VAc-alt-MAF-TBE copolymers at moderate temperature (<40 °C in bulk. The resulting alternating copolymer was characterized by 1H-, 13C- and 19F-nuclear magnetic resonance (NMR spectroscopies, and by size exclusion chromatography. The linear first-order kinetic plot, the linear evolutions of the molar mass with total monomer conversion, and the relatively low dispersity (Đ~1.55 of the resulting copolymers suggest that this cobalt complex provides some degree of control over the copolymerization of VAc and MAF-TBE. Compared to the previously investigated cobalt complex OMRP mediators having a fully oxygen-based first coordination sphere, this study emphasizes a few peculiarities of Co(SAL2: a lower ability to trap radical chains as compared to Co(acac2 and the absence of catalytic chain transfer reactions, which dominates polymerizations carried in the presence of 9-oxyphenalenone cobalt derivative.

  18. The p-T phase diagram for ferroelectric bis-thiourea pyridinium nitrate

    International Nuclear Information System (INIS)

    Bilski, P.; Czarnecki, P.; Lewicki, S.; Wasicki, J.

    2011-01-01

    Highlights: → Bis-thiourea pyridinium nitrate has been studied at high pressures up to 1 GPa. → p-T phase diagram has been obtained by NMR and dielectric method. → The triple point is observed in p-T diagram. → The continuous phase transition is changed to discontinuous at the pressure 450 Mpa. - Abstract: The effect of temperature and pressure on physical properties of the ferroelectric bis-thiourea pyridinium nitrate inclusion compound has been studied by dielectric spectroscopy and nuclear magnetic resonance (NMR). At ambient pressure the ferroparaelectric phase transition observed at T 2 = 216 K is continuous in contrast to the nonferroelectric phase transition observed at T 1 = 273 K. Under small pressures, the temperatures of the phase transitions T 1 and T 2 increase with increasing pressure. Starting from about 250 MPa, T 1 temperature decreases with increasing pressure, while T 2 temperature increases with increasing pressure. At 450 MPa and 245 K a triple point is observed. Bis-thiourea pyridinium nitrate undergoes a continuous phase transition from the ferroelectric to paraelectric phase under 450 MPa, while above this pressure the phase transition from the ferroelectric to paraelectric phase is discontinuous. The change in the phase transition character is related to the crystallographic change in the group-subgroup relation between the ferro- and paraelectric phases taking place with increasing pressure.

  19. Fine and Clean Photothermally Controlled NIR Drug Delivery from Biocompatible Nickel-bis(dithiolene)-Containing Liposomes.

    Science.gov (United States)

    Mebrouk, Kenny; Ciancone, Mathieu; Vives, Thomas; Cammas-Marion, Sandrine; Benvegnu, Thierry; Le Goff-Gaillard, Catherine; Arlot-Bonnemains, Yannick; Fourmigué, Marc; Camerel, Franck

    2017-11-08

    This work demonstrates that metal-bis(dithiolene) complexes can be efficiently incorporated inside organic nanocarriers and, that under near-infrared (NIR) irradiation, their high photothermal activity can be finely used to release encapsulated drugs on demand. In contrast to gold nanoparticles and other organic NIR dyes, nickel-bis(dithiolene) complexes do not produce singlet oxygen under irradiation, a highly desirable characteristic to preserve the chemical integrity and activity of the loaded drug during the NIR-triggered release from the nanocarriers. Finally, cytotoxicity experiments performed on various cell lines have shown that the incorporation of such metal complexes do not increase the toxicity of the final liposomal formulation. These results offer great promise for the development of innovative biocompatible drug nanocargos that are able to safely deliver their content on demand under NIR laser irradiation. Moreover, this work demonstrates that metal-bis(dithiolene) complexes, owing to their versatility of functionalization and metal complexation, are attractive photothermal agents for the development of original NIR-responsive materials for application not only in biotechnology but also in materials science. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Effects of bis(guanylhydrazones) on the activity and expression of ornithine decarboxylase.

    Science.gov (United States)

    Nikula, P; Alhonen-Hongisto, L; Jänne, J

    1985-01-01

    Derivatives of glyoxal bis(guanylhydrazone) (GBG), such as methylglyoxal bis(guanylhydrazone) and ethylglyoxal bis(guanylhydrazone), are potent inhibitors of S-adenosylmethionine decarboxylase (EC 4.1.1.50), the key enzyme required for the synthesis of spermidine and spermine. These compounds, but not the parent compound, induce a massive accumulation of putrescine, partly by blocking the conversion of putrescine into spermidine, but also by strikingly stimulating ornithine decarboxylase (ODC; EC 4.1.1.17) activity. The mechanism of the stimulation of ODC activity and enhanced accumulation of the enzyme protein apparently involved a distinct stabilization of the enzyme against intracellular degradation. However, although the parent compound GBG also stabilized ODC, it powerfully inhibited the enzyme activity and the accumulation of immunoreactive protein in cultured L1210 leukaemia cells. Kinetic considerations indicated that, in addition to the stabilization, all three compounds, GBG in particular, inhibited the expression of ODC. It is unlikely that the decreased rate of synthesis of ODC was attributable to almost unaltered amounts of mRNA in drug-treated cells, thus supporting the view that especially GBG apparently depressed the expression of ODC at some post-transcriptional level. Images PMID:4062886

  1. Synthesis and DNA cleavage activity of Bis-3-chloropiperidines as alkylating agents.

    Science.gov (United States)

    Zuravka, Ivonne; Roesmann, Rolf; Sosic, Alice; Wende, Wolfgang; Pingoud, Alfred; Gatto, Barbara; Göttlich, Richard

    2014-09-01

    Nitrogen mustards are an important class of bifunctional alkylating agents routinely used in chemotherapy. They react with DNA as electrophiles through the formation of highly reactive aziridinium ion intermediates. The antibiotic 593A, with potential antitumor activity, can be considered a naturally occurring piperidine mustard containing a unique 3-chloropiperidine ring. However, the total synthesis of this antibiotic proved to be rather challenging. With the aim of designing simplified analogues of this natural product, we developed an efficient bidirectional synthetic route to bis-3-chloropiperidines joined by flexible, conformationally restricted, or rigid diamine linkers. The key step involves an iodide-catalyzed double cyclization of unsaturated bis-N-chloroamines to simultaneously generate both piperidine rings. Herein we describe the synthesis and subsequent evaluation of a series of novel nitrogen-bridged bis-3-chloropiperidines, enabling the study of the impact of the linker structure on DNA alkylation properties. Our studies reveal that the synthesized compounds possess DNA alkylating abilities and induce strand cleavage, with a strong preference for guanine residues. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Different Strategies to Bond Bis-GMA-based Resin Cement to Zirconia.

    Science.gov (United States)

    Lopes, Guilherme Carpena; Spohr, Ana Maria; De Souza, Grace M

    To evaluate the effect of different bonding strategies on short- and long-term bis-GMA-based resin cement bond strengths to zirconia. One hundred twenty samples of fully-sintered zirconia (Prettau Zirconia) were sandblasted and randomly distributed into 5 groups (n = 24): UA: Scotchbond Universal Adhesive; SZP: Signum Zirconia Bond I + II; ZPP: Z-Prime Plus; EXP: MZ experimental primer; CO: no primer application (control). After performing these surface treatments, translucent tubes (0.8 mm diameter and 1.0 mm height) were placed on the zirconia specimens, and bis-GMA-based cement (Duo-Link) was injected into them and light cured. Specimens were tested for microshear bond strength either 24 h or 6 months (m) after water storage (37°C) and surfaces were characterized by SEM and EDX. Two-way ANOVA and Tukey's post-hoc test (p zirconia surface. In these groups, EDX demonstrated the presence of phosphorus. Group ZPP resulted in a nonhomogeneous layer, exposing the zirconia substrate underneath. EXP application resulted in an undetectable layer. Water storage did not affect resin cement bond strengths to zirconia irrespective of the surface treatment. Bis-GMA-based resin cement bond strengths to zirconia are affected by specific bonding strategies.

  3. Synthesis of novel pyrazoline based bis (1,2,3-triazole scaffolds via click chemistry

    Directory of Open Access Journals (Sweden)

    Kiran Kothuri

    2017-01-01

    Full Text Available A series of novel bis(1,2,3-triazoles derivatives 7a–m were synthesized by the 1,3-dipolar cycloaddition (click-reaction of 1-methyl-3,5-bis(2- -(prop-2-yn-1-yloxyphenyl-4,5-dihydro-1H-pyrazole (5 with various aralkyl azides 6a–m in the presence of sodium ascorbate and copper sulphate with good yields. The required precursor 5 was synthesized by reacting (E-1,3- -bis(2-hydroxyphenylprop-2-en-1-one (3 with methylhydrazine hydrate via 2,2′-(1-methyl-4,5-dihydro-1H-pyrazole-3,5-diyldiphenol 4, followed by reaction with propargyl bromide. The homogeneity of all the newly synthesized compounds was checked by TLC. The IR, NMR, mass spectral data and elemental analysis were in accord with the assigned structure. The title compounds were evaluated for their antibacterial activity against various bacterial strains, i.e., Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis; compounds 7f–7h and 7j were found to be moderately active against the bacteria, when compared with that of the standard drug. Furthermore, the same library of compounds was evaluated for their antioxidant activity using the nitric oxide radical scavenging activity. The results of the study showed that compounds 7e–7h and 7k–7m showed good radical scavenging activity.

  4. Gold(III) bis(thiosemicarbazonate) compounds in breast cancer cells: Cytotoxicity and thioredoxin reductase targeting.

    Science.gov (United States)

    Rodríguez-Fanjul, Vanessa; López-Torres, Elena; Mendiola, M Antonia; Pizarro, Ana María

    2018-03-25

    Gold(III) compounds have received increasing attention in cancer research. Three gold complexes of general formula [Au III L]Cl, where L is benzil bis(thiosemicarbazonate), compound 1, benzil bis(4-methyl-3-thiosemicarbazonate), compound 2, or benzil bis(4-cyclohexyl-3-thiosemicarbazonate), compound 3, have been synthesized and fully characterized, including the X-ray crystal structure of compound 3, confirming square-planar geometry around the gold(III) centre. Compound 1 showed moderate cytotoxicity and accumulation in MCF7 breast cancer cells but did not inhibit thioredoxin reductase (TrxR) activity and did not induce reactive oxygen species (ROS) production. Compound 2, the least cytotoxic, was found to be capable of modestly inhibiting TrxR activity and produced low levels of ROS in the MCF7 cell line. The most cytotoxic compound, 3, had the highest cellular accumulation and its distribution pattern showed a clear preference for the cytosol and mitochondria of MCF7 cells. It readily hampered intracellular TrxR activity leading to a dramatic alteration of the cellular redox state and to the induction of cell death. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  5. Theoretical investigations on vibrational spectra of pillar[5]arene-bis(pyridinium) complexes

    Science.gov (United States)

    Peerannawar, Swarada R.; Gejji, Shridhar P.

    2013-03-01

    Electronic structure and vibrational spectra of pillar[5]arene (P5) complexes with bis(pyridinium) derivatives viz., 1,2-ethylenedipyridine (edpy), 1,2-propylenedipyridine (3-pdpy), 1,2-butylenedipyridine (bdpy), 1,2-pentamethylenedipyridine (pdpy) and 1,2-hexamethylenedipyridine (hdpy) are investigated employing density functional theory. B3LYP based density functional calculations predicted that interaction energies for complexation decreases steadily with increasing alkyl chain of bis(pyridinium) guest. The calculations have shown that Osbnd H⋯O hydrogen bonded and non-bonded hydroxyls in the host led to distinct vibrations at the 3515 cm-1 and 3681 cm-1, respectively in the vibrational spectra. Complexation of bis(pyridinium) guest engenders frequency down-shift for aromatic Csbnd Hα vibrations owing to Csbnd H⋯O interactions with P5 portals. Moreover, Csbnd H⋯π interactions are inferred in edpy@P5 and 3-pdpy@P5 complexes which results in frequency up-shift (blue shift) of nearly 22-15 cm-1 for the corresponding Csbnd Hα vibration.

  6. {μ2-1,4-Bis[2-(4-pyrid­yl)ethen­yl]benzene-κ2 N:N′}bis­[bis­(acetyl­acetonato-κ2 O,O′)copper(II)

    Science.gov (United States)

    Jian, Fang-Fang; Wang, Jing; Zhang, Jing

    2009-01-01

    The asymmetric unit of the title compound, [Cu2(C5H7O2)4(C20H16N2)], contains half of a centrosymmetric dinuclear mol­ecule. In the mol­ecule, each Cu center is coordinated by four O atoms from two acetyl­acetonate ligands and one N atom from the bridging linear 1,4-bis­[2-(4-pyrid­yl)ethen­yl]benzene ligand in a square-pyramidal geometry. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds link mol­ecules into sheets parallel to the bc plane. PMID:21578648

  7. Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation.

    Science.gov (United States)

    Jänne, J; Morris, D R

    1984-03-15

    Several congeners of methylglyoxal bis(guanylhydrazone) were tested for their ability to inhibit eukaryotic putrescine-activated S-adenosylmethionine decarboxylase (EC 4.1.1.50) and intestinal diamine oxidase (EC 1.4.3.6). All the compounds tested, namely methylglyoxal bis(guanylhydrazone), ethylglyoxal bis(guanylhydrazone), dimethylglyoxal bis(guanylhydrazone) and the di-N"-methyl derivative of methylglyoxal bis(guanylhydrazone), were strong inhibitors of both yeast and mouse liver adenosylmethionine decarboxylase activity in vitro. The enzyme from both sources was most powerfully inhibited by ethylglyoxal bis(guanylhydrazone). All the diguanidines likewise inhibited diamine oxidase activity in vitro. The maximum intracellular concentrations of the ethyl and dimethylated analogues achieved in activated lymphocytes were only about one-fifth of that of the parent compound. However, both derivatives appeared to utilize the polyamine-carrier system, as indicated by competition experiments with spermidine.

  8. Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes.

    Science.gov (United States)

    Dömötör, Orsolya; de Almeida, Rodrigo F M; Côrte-Real, Leonor; Matos, Cristina P; Marques, Fernanda; Matos, António; Real, Carla; Kiss, Tamás; Enyedy, Éva Anna; Helena Garcia, M; Tomaz, Ana Isabel

    2017-03-01

    Two recently published Ru(III) complexes bearing (N 2 O 2 ) tetradentate bis(aminophenolate) ligands, formulated as [Ru(III)(salan)(PPh 3 )Cl] (salan is the tetradentate ligand 6,6'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(3-methoxyphenol) in complex 1, or 2,2'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(4-methoxyphenol) in complex 2; PPh 3 is triphenylphosphane) and found very active against ovarian and breast adenocarcinoma human cells were studied to outline their antitumor mode of action. The human cisplatin-sensitive ovarian adenocarcinoma line A2780 was used herein as the cell model. At a 24h challenge (similarly as found before for 72h) both complexes are active, their cytotoxicity being comparable to that of cisplatin in the same conditions. As a possible target in the cell for their action, the interaction of 1 and 2 with DNA was assessed through displacement of well-established DNA fluorescent probes (ethidium bromide, EB, and 4',6-diamidino-2-phenylindole, DAPI) through steady-state and time-resolved fluorescence spectroscopy. The whole emission spectra were analyzed globally for the binary DNA-probe and ternary DNA-probe-Ru(III) complex systems. Both Ru(III) complexes can displace EB and bind to DNA with similar and moderate strong affinity with conditional stability constants of logK'=(5.05±0.01) for 1 and logK'=(4.79±0.01) for 2. The analysis of time-domain fluorescence intensity decays confirmed both qualitatively and quantitatively the model used to describe the binding and competition processes. Cell studies indicated that apoptosis is the major mechanism of cell death for both complexes, with 2 (the more active complex) promoting that process more efficiently than 1. Transmission electron micrographs revealed clear alterations on intracellular organization consistent with the induction of programmed cell death processes. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. MACARRÃO ADICIONADO DE ORA-PRO-NÓBIS (PERESKIA ACULEATA MILLER DESIDRATADO

    Directory of Open Access Journals (Sweden)

    Débora Regina da Cunha ROCHA

    2009-06-01

    Full Text Available

    A utilização de alimentos alternativos para o combate à fome na população de baixa renda é assunto que tem recebido atenção no Brasil nos últimos anos. As hortaliças não-convencionais constituem uma alternativa para populações carentes por serem boas fontes de nutrientes, apresentarem fácil disponibilidade, além de baixo valor de mercado. Diante disso, o presente trabalho objetivou elaborar e caracterizar física, química e sensorialmente o macarrão tipo talharim com diferentes proporções de ora-pro-nóbis. O ora-pro-nóbis desidratado foi caracterizado quanto sua composição física e química, além de sua utilização do para elaboração das massas de macarrão tipo talharim com diferentes concentrações (1,0; 1,5 e 2,0%, estas foram submetidas a pesquisa de preferência e a formulação preferida foi avaliada quanto a aceitabilidade. O ora-pro-nóbis desidratado apresentou consideráveis teores de proteínas (22,93%, fibras (12,64% e cinzas (18,07%. Dentre as formulações testadas a de maior preferência, formulação com 2,0 % de ora-pro-nóbis, se destacou por apresentar maior conteúdo de proteínas, fibras e cinzas quando comparado com o macarrão convencional. Os resultados demonstram que o uso de 2,0% de ora-pro-nóbis desidratado no macarrão tipo talharim elevou os teores de proteínas, fibras e cinzas em relação ao macarrão convencional. Na avaliação sensorial, o macarrão com adição de ora-pro-nóbis foi aceito por apresentar índice de aceitabilidade de 92,0%. A utilização do ora-pro-nóbis na elaboração de vários produtos alimentícios contribuirá para aumento do seu cultivo, bem como para a melhoria da qualidade da dieta da população.

  10. Rhenium(V) and technetium(V) complexes of bis(o-hydroxyphenyl)phenylphosphine (PO22-) and (o-hydroxyphenyl)diphenylphosphine (PO-) ligands

    International Nuclear Information System (INIS)

    Luo, Hongyan; Setyawati, Ika; Rettig, S.J.; Orvig, C.

    1995-01-01

    The synthesis of several phosphine-based chelating compounds and chelates formed between these compounds and rhenium or technetium is discussed. Four categories of products result, (i) bis-(o-hydroxyphenyl) diphenylphosphine (PO) complexes, (ii) mono- (PO) complexes, (iii) bis-bis(o-hydroxyphenyl)-phenylphosphine (PO 2 ) complexes, and mixed-(PO) and (PO 2 ) complexes. Molecular structures of these compounds (including isomers) were probed by NMR, MS, and IR spectroscopies and by X-ray crystallography

  11. Synthesis of mono- and geminal dimetalated carbanions of bis(phenylsulfonyl)methane using alkali metal bases and structural comparisons with lithiated bis(phenylsulfonyl)imides.

    Science.gov (United States)

    MacDougall, Dugald J; Kennedy, Alan R; Noll, Bruce C; Henderson, Kenneth W

    2005-06-21

    The alpha,alpha'-stabilized carbanion complexes [(PhSO2)2CHLi.THF]1, [(PhSO2)2CHNa.THF]2 and [(PhSO2)2CHK]3 were prepared by the direct deprotonation of bis(phenylsulfonyl)methane I in THF with one molar equivalent of MeLi, BuNa and BnK respectively. The geminal dianionic complexes [(PhSO2)2CLi2.THF]4, [(PhSO2)2CNa2.0.55THF]5 and [(PhSO2)2CK2]6 were similarly prepared by the reaction of I with two molar equivalents of MeLi, BuNa and BnK respectively in THF. NMR and MS solution studies of 1-3 are consistent with the formation of charge-separated species in DMSO media. Solutions studies of 4-6, in conjunction with trapping experiments, indicate that the dianions deprotonate DMSO and regenerate the monoanions 1-3. Crystallographic analysis of 1 revealed a 1D chain polymer in which the metal centers are chelated by the bis(sulfonyl) ligands and connect to neighboring units through Li-O(S) interactions. An unexpected feature of 1 is that the polymeric chains are homochiral, since the chelating ligands of the backbone adopt the same relative configuration. Also, the phenyl substituents of each chelate in 1 are oriented in a cisoid manner. The sodium derivative 2 adopts a related solid-state structure, where enantiomeric pairs of chains combine to give a 1D ribbon motif. The lithium bis(phenylsulfonyl)imides [(PhSO2)2NLi.THF]9 and [(PhSO2)2NLi.Pyr2]10 were also prepared and structurally characterized. In the solid state 9 has a similar connectivity to that found for 1 but with heterochiral chains. In comparison, the more highly solvated complex 10 forms a 1D polymeric arrangement without chelation of the ligands and with the phenyl substituents oriented in a transoid fashion.

  12. Cyclic Bis-porphyrin-Based Flexible Molecular Containers: Controlling Guest Arrangements and Supramolecular Catalysis by Tuning Cavity Size.

    Science.gov (United States)

    Mondal, Pritam; Sarkar, Sabyasachi; Rath, Sankar Prasad

    2017-05-23

    Three cyclic zinc(II) bis-porphyrins (CB) with highly flexible linkers are employed as artificial molecular containers that efficiently encapsulate/coordinate various aromatic aldehydes within their cavities. Interestingly, the arrangements of guests and their reactivity inside the molecular clefts are significantly influenced by the cavity size of the cyclic containers. In the presence of polycyclic aromatic aldehydes, such as 3-formylperylene, as a guest, the cyclic bis-porphyrin host with a smaller cavity (CB1) forms a 1:1 sandwich complex. Upon slightly increasing the spacer length and thereby the cavity size, the cyclic host (CB2) encapsulates two molecules of 3-formylperylene that are also stacked together due to strong π-π interactions between them and CH-π interactions with the porphyrin rings. However, in the cyclic host (CB3) with an even larger cavity, two metal centers of the bis-porphyrin axially coordinate two molecules of 3-formylperylene within its cavity. Different arrangements of guest inside the cyclic bis-porphyrin hosts are investigated by using UV/Vis, ESI-MS, and 1 H NMR spectroscopy, along with X-ray structure determination of the host-guest complexes. Moreover, strong binding of guests within the cyclic bis-porphyrin hosts support the robust nature of the host-guest assemblies in solution. Such preferential binding of the bis-porphyrinic cavity towards aromatic aldehydes through encapsulation/coordination has been employed successfully to catalyze the Knoevenagel condensation of a series of polycyclic aldehydes with active methylene compounds (such as Meldrum's acid and 1, 3-dimethylbarbituric acid) under ambient conditions. Interestingly, the yields of the condensed products significantly increase upon increasing spacer lengths of the cyclic bis-porphyrins because more substrates can then be encapsulated within the cavity. Such controllable cavity size of the cyclic containers has profound implications for constructing highly

  13. Bis(benzimidazole)amine vanadium catalysts for olefin polymerisation and co-polymerisation: thermally robust, single-site catalysts activated by simple alkylaluminium reagents.

    Science.gov (United States)

    Tomov, Atanas K; Gibson, Vernon C; Zaher, Damien; Elsegood, Mark R J; Dale, Sophie H

    2004-09-07

    Vanadium complexes containing bis(benzimidazole)amine ligands, upon activation by simple alkylaluminium reagents, give unusually robust, single-site, catalysts for olefin polymerisation/co-polymerisation.

  14. X-ray Structure and Magnetic Properties of two new iron(II) 1D Coordination Polymers with Bis(imidazolyle)methane as bridging ligand

    OpenAIRE

    Weber , Birgit

    2009-01-01

    Abstract The reaction of iron(II) acetate with the tetradentate Schiff base like ligands H2L1 ((E,E)-[{diethyl 2,2'-[1,2-phenylenebis-(iminomethyl-idyne)]bis[3-oxobutanato]}]) and H2L2 ([([3,3']-[1,2-phenylene-bis(iminomethylidyne)]bis(2,4-pentane-dionato)(2-)-N,N',O2,O2']) leads to the formation of the octahedral N2O4 coordinated iron complexes [FeL1(MeOH)2] and [FeL2(MeOH)2], respectively. Conversion of both with bimm (bis(1-imidazolyle)methane) leads to the 1D coordination polym...

  15. Synthesis of fluorinated poly(arylene ether)s with dibenzodioxin and spirobisindane units from new bis(pentafluorophenyl)- and bis(nonafluorobiphenyl)-containing monomers

    DEFF Research Database (Denmark)

    Tkachenko, Ihor M.; Belov, Nikolay A.; Kobzar, Yaroslav L.

    2017-01-01

    ,1′-spirobisindane. The chemical structures of the prepared monomers and polymers were determined using 1H, 13C, 19F NMR and FTIR spectroscopy techniques. All the obtained polymers were completely soluble in chloroform, tetrahydrofuran, dimethylformamide, and dimethyl sulfoxide. Polymers derived from 4,4′-bis......(nonafluorophenyl)-containing monomers have higher average molecular masses (Mw) in the range 47,000–88,300 and are able to form robust, solvent-cast films. Good thermal stabilities in air (up to 350 °C) were observed in all fluorinated polymers. The Brunauer–Emmett–Teller specific surface area and the pore size of polymers can...... be controlled by varying the type of the initial fluorinated monomers. It was shown that introduction of perfluorobiphenyl units is an effective tool for increasing the surface area up to 156.8 m2 g−1....

  16. Bis(4-acetyl-3-methyl-1-phenyl-1H-pyrazol-5-olato-κO,O')bis-(N,N-dimethyl-formamide-κO)nickel(II).

    Science.gov (United States)

    Zhu, Hualing; Wei, Zhen; Bu, Luxia; Xu, Xiaoping; Shi, Jun

    2010-07-10

    The title complex, [Ni(C(12)H(11)N(2)O(2))(2)(C(3)H(7)NO)(2)], lies on on an inversion center. The Ni(II) ion is coordinated in a slightly distorted octa-hedral coordination enviroment by four O atoms from two bis-chelating 4-acety-3-methyl-1-phenyl-1H-pyrazol-5-olate ligands in the equatorial plane and two O atoms from two N,N-dimethyl-formamide ligands in the axial sites. In the crystal structure, weak inter-molecular π-π stacking inter-actions with centroid-centroid distances of 3.7467 (13) Å link mol-ecules into chains extending alongthe b axis.

  17. Bis(2-amino-5-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium bis(4-methoxyphenyldiphosphonate

    Directory of Open Access Journals (Sweden)

    Mehmet Akkurt

    2014-03-01

    Full Text Available The asymmetric unit of the title salt, 2C17H21N2O2S+·C14H14O7P22−, contains half of a centrosymmetric bis(4-methoxyphenyldiphosphonate anion and one 2-amino-5-benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium cation. In the anion, the O atoms of the diphosphonate group are disordered over two positions with equal occupancies. In the cation, the ethyl group is disordered over two orientations with a refined occupancy ratio of 0.753 (5:0.247 (5, and the tetrahydropyridinium ring adopts a distorted half-chair conformation. In the crystal, the ions are linked by C—H...O, N—H...O and C—H...S hydrogen bonds into a three-dimensional network.

  18. Poly[[[diisothiocyanatocobalt(II]-bis[μ-4-tert-butyl-2,6-bis(1,2,4-triazol-1-ylmethylphenol

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available In the title compound, {[Co(NCS2(C16H20N6O2]·2C3H7NO·2H2O}n, each CoII ion located on an inversion center is six-coordinated by four equatorial N atoms from four different 4-tert-butyl-2,6-bis(1,2,4-triazol-1-ylmethylphenol (L ligands, and by two N atoms from two axial thiocyanate anions [Co—N = 2.104 (3–2.144 (3 Å]. The metal centres are connected via the bidentate L ligands into two-dimensional polymeric layers parallel to bc plane. The dimethylformamide and solvent water molecules participate in intermolecular O—H...O and O—H...S hydrogen bonds, which consolidate the crystal packing.

  19. Two-dimensional structure of poly[[[μ2-1,4-bis(pyridin-4-ylbutane]bis(μ4-pentanedioatodicopper(II] acetonitrile disolvate

    Directory of Open Access Journals (Sweden)

    Do Nam Lee

    2017-10-01

    Full Text Available In the title compound, {[Cu2(μ4-C5H6O42(μ2-C14H16N2]·2CH3CN}n, the Cu2 dinuclear units are connected by glutartate ligands, forming one-dimensional double chains. These chains, are in turn bridged by 1,4-bis(pyridin-4-ylbutane ligands to form a two-dimensional layer structure parallel to (112. The carboxylate groups of the glutarate ligand bridge two copper(II ions, forming a paddle-wheel-type Cu2(CO24 dinuclear secondary building unit. A crystallographic inversion centre is located midway between two CuII ions, with a Cu...Cu distance of 2.639 (3 Å. The coordination geometry of the unique CuII ion is slightly disorted square pyramidal, formed by four equatorial carboxylate O atoms and an axial pyridyl N atom.

  20. Crystal structure of bis[N,N-bis(2-hydroxyethylglycinato-κ3O1,N,O2]cobalt(II monohydrate

    Directory of Open Access Journals (Sweden)

    Yang Liu

    2015-11-01

    Full Text Available The title compound, [Co(C6H12O42]·H2O, was prepared by mild heating of an aqueous solution. The CoII ion has a slightly distorted octahedral coordination environment which is defined by two N atoms occupying the apical position, while the equatorial plane is furnished by two hydroxy O atoms and two carboxylate O atoms. The four hydroxy O atoms from two distinct N,N-bis(2-hydroxyethylglycine (bicH2− ligands act as hydrogen-bond donors with two carboxylate O atoms as acceptors to form O—H...O hydrogen-bonded layers extending parallel to (100. In addition, the guest water molecule acts as both a hydrogen-bond donor and acceptor, so that each Co(bicH22 molecule is connected simultaneously to six neighbouring Co(bicH22 and two guest water molecules by hydrogen bonding.

  1. Study of supramolecular frameworks having aliphatic dicarboxylic acids, N,N‧-bis(salicyl)ethylenediamine and N,N‧-bis(salicyl)butylenediamine

    Science.gov (United States)

    Goel, Nidhi; Kumar, Naresh

    2014-08-01

    The reaction of bases (L1 and L2) (where L1 = N,N‧-bis(salicyl)ethylenediamine, L2 = N,N‧-bis(salicyl)butylenediamine) with dicarboxylic acids [adipic acid (1,6-Hexanedioic acid, AA), pimelic acid (1,7-Heptanedioic acid, PA) and suberic acid (1,8-Octanedioic acid, SUA] yielded the corresponding six new ionic salts viz., [1/2L1H+ṡ1/2AA-ṡ1/2AA] (1), [2 × 1/2L1H+ṡPA2-ṡCHCl3] (2) [1/2L1H+ṡ1/2SUA-] (3), [1/2L2H+ṡ1/2AA-ṡ2CH3OH] (4), [1/2L2H+ṡ1/2PA-] (5) and [1/2L2H+ṡ1/2SUA-] (6), respectively. Theses salts were characterized by elemental analysis, FT-IR, NMR, X-ray crystallography, and theoretically by means of Gaussian 09. The X-ray crystallographic studies revealed that the proton transfer occurred from acid to base. It also demonstrated that different type of hydrogen bond interactions between cations and anions were responsible for the supramolecular frameworks. The optimized structures of these salts were calculated in terms of the density functional theory. The curve fitting analysis between experimental and simulated data of structural parameters was done, and found statistically close. The orientation of molecules was remained same in both the gas and solid phases. The thermal studies of these salts were investigated by TG-DTG.

  2. Dust measurement of two organophosphorus flame retardants, resorcinol bis(diphenylphosphate) (RBDPP) and bisphenol A bis(diphenylphosphate) (BPA-BDPP), used as alternatives for BDE-209.

    Science.gov (United States)

    Brandsma, Sicco H; Sellström, Ulla; de Wit, Cynthia A; de Boer, Jacob; Leonards, Pim E G

    2013-12-17

    Resorcinol bis(diphenylphosphate) (RBDPP) and bisphenol A bis(diphenylphosphate) (BPA-BDPP) are two halogen-free organophosphorus flame retardant (PFRs) that are used as an alternative for the decabromodiphenyl ether (Deca-BDE) technical mixture in TV/flatscreen housing and other electronic consumer products. In this study, dust samples were collected from various microenvironments in The Netherlands (houses, cars), Greece (houses), and Sweden (apartments, cars, furniture stores, electronics stores) and analyzed for RBDPP and BPA-BDPP. Additionally, the dust samples from The Netherlands were analyzed for decabromodiphenyl ether (BDE-209) for comparison and for TPHP, which is a byproduct in the RBDPP and BPA-BDPP technical products. BPA-BDPP was detected in almost all dust samples from The Netherlands, Greece, and Sweden. Highest concentrations were found in dust samples collected on electronic equipment from all three countries with BPA-BDPP levels ranging from <0.1 to 1300 μg/g and RBDPP levels from <0.04 to 520 μg/g. RBDPP and BPA-BDPP levels in dust collected further away from the electronics (source) were usually lower. BDE-209 levels in The Netherlands dust samples collected on and around the electronics were similar and much lower than the BPA-BDPP/RBDPP levels, indicating that the electronics were not the source of BDE-209. Strong positive correlations were found between TPHP concentrations and those of RBDPP (r = 0.805) and BPA-BDPP (r = 0.924), probably due to TPHP being a byproduct in commercial RBDPP and BPA-BDPP mixtures in electronics. To our knowledge, this is the first time that RBDPP and BPA-BDPP were detected in dust samples from Europe.

  3. Regulatory behavior and frontal activity: Considering the role of revised-BIS in relative right frontal asymmetry.

    Science.gov (United States)

    Gable, Philip A; Neal, Lauren B; Threadgill, A Hunter

    2018-01-01

    Essential to human behavior are three core personality systems: approach, avoidance, and a regulatory system governing the two motivational systems. Decades of research has linked approach motivation with greater relative left frontal-cortical asymmetry. Other research has linked avoidance motivation with greater relative right frontal-cortical asymmetry. However, past work linking withdrawal motivation with greater relative right frontal asymmetry has been mixed. The current article reviews evidence suggesting that activation of the regulatory system (revised Behavioral Inhibition System [r-BIS]) may be more strongly related to greater relative right frontal asymmetry than withdrawal motivation. Specifically, research suggests that greater activation of the r-BIS is associated with greater relative right frontal activity, and reduced r-BIS activation is associated with reduced right frontal activity (greater relative left frontal activity). We review evidence examining trait and state frontal activity using EEG, source localization, lesion studies, neuronal stimulation, and fMRI supporting the idea that r-BIS may be the core personality system related to greater relative right frontal activity. In addition, the current review seeks to disentangle avoidance motivation and r-BIS as substrates of relative right frontal asymmetry. © 2017 Society for Psychophysiological Research.

  4. Conformational switching of ethano-bridged Cu,H2-bis-porphyrin induced by aromatic amines.

    Science.gov (United States)

    Bettini, Simona; Maglie, Emanuela; Pagano, Rosanna; Borovkov, Victor; Inoue, Yoshihisa; Valli, Ludovico; Giancane, Gabriele

    2015-01-01

    Cu,H2-bis-porphyrin (Cu,H2-Por2), in which copper porphyrin and free-base porphyrin are linked together by an ethano-bridge, was dissolved in chloroform and spread at the air/liquid subphase interface of a Langmuir trough. The bis-porphyrin derivative, floating film was characterized by reflection spectroscopy and the surface pressure of the floating film was studied as a function of the mean area per molecule. When aromatic amines are dissolved in the subphase, an evident interaction between the bis-porphyrin host and the aromatic amine guest is observed. A clear-cut variation of the profile of surface pressure vs area per molecule curve is observed. Reflection spectroscopy highlights that the aromatic amines dissolved in the subphase are able to induce the syn-to-anti conformational switching in the bis-porphyrin derivative. The Langmuir-Schaefer technique has been used to transfer the floating bis-porphyrin film (when using pure water as a subphase) to a surface plasmon resonance (SPR) substrate and the resulting device was able to detect the presence of aniline at concentrations as low as 1 nM in aqueous solution. The high selectivity of the SPR sensing device has been verified by checking the spectral response of the active layer towards other analytes dissolved in the aqueous solutions.

  5. Conformational switching of ethano-bridged Cu,H2-bis-porphyrin induced by aromatic amines

    Directory of Open Access Journals (Sweden)

    Simona Bettini

    2015-11-01

    Full Text Available Cu,H2-bis-porphyrin (Cu,H2-Por2, in which copper porphyrin and free-base porphyrin are linked together by an ethano-bridge, was dissolved in chloroform and spread at the air/liquid subphase interface of a Langmuir trough. The bis-porphyrin derivative, floating film was characterized by reflection spectroscopy and the surface pressure of the floating film was studied as a function of the mean area per molecule. When aromatic amines are dissolved in the subphase, an evident interaction between the bis-porphyrin host and the aromatic amine guest is observed. A clear-cut variation of the profile of surface pressure vs area per molecule curve is observed. Reflection spectroscopy highlights that the aromatic amines dissolved in the subphase are able to induce the syn-to-anti conformational switching in the bis-porphyrin derivative. The Langmuir–Schaefer technique has been used to transfer the floating bis-porphyrin film (when using pure water as a subphase to a surface plasmon resonance (SPR substrate and the resulting device was able to detect the presence of aniline at concentrations as low as 1 nM in aqueous solution. The high selectivity of the SPR sensing device has been verified by checking the spectral response of the active layer towards other analytes dissolved in the aqueous solutions.

  6. Biochemical properties and crystal structure of ethylmethylglyoxal bis(guanylhydrazone) sulfate--an extremely powerful novel inhibitor of adenosylmethionine decarboxylase.

    Science.gov (United States)

    Elo, H; Mutikainen, I; Alhonen-Hongisto, L; Laine, R; Jänne, J; Lumme, P

    1986-01-01

    Ethylmethylglyoxal bis(guanylhydrazone) (EMGBG) sulfate, an analog of the well-known anti-leukemic drug methylglyoxal bis(guanylhydrazone), was synthesized. It was shown to be an extremely powerful competitive inhibitor of eukaryotic S-adenosylmethionine decarboxylase, with an apparent Ki value 12 nM. Thus, it appears to be the most powerful known inhibitor of the enzyme, being almost an order of magnitude more powerful than the corresponding ethylglyoxal derivative. It neither inhibited the proliferation of mouse L1210 leukemia cells in vitro, nor did it potentiate the growth inhibition produced by alpha-difluoromethyl ornithine. In this respect, its properties are closely related to those of dimethylglyoxal, ethylglyoxal and propylglyoxal bis(guanylhydrazones), while in striking contrast to those of the antiproliferative glyoxal and methylglyoxal analogs. EMGBG also inhibited intestinal diamine oxidase activity (Ki 0.7 microM). EMGBG sulfate was crystallized from water, giving orthorhombic crystals (space group Pbcn). Their crystal and molecular structure was determined by X-ray diffraction methods. The carbon-nitrogen double bonds between the ethylmethylglyoxal part and the aminoguanidine moieties were found to have the same configuration as they are known to have in the salts of glyoxal, methylglyoxal and propylglyoxal bis(guanylhydrazones). The glyoxal bis(guanylhydrazone) chain of the EMGBG cation deviated strongly from planarity, thus differing dramatically from the corresponding chains of the glyoxal, methylglyoxal and propylglyoxal analogs.

  7. Trypanocidal 1,3-arylene diketone bis(guanylhydrazone)s. Structure-activity relationships among substituted and heterocyclic analogues.

    Science.gov (United States)

    Ulrich, P; Cerami, A

    1984-01-01

    Based on the antitrypanosomal activity of 1,3-diacetylbenzene bis(guanylhydrazone) (4) and 2,6-diacetylpyridine bis(guanylhydrazone) (17), a number of substituted and heterocyclic 1,3-arylene diketone bis(guanylhydrazone)s were prepared and tested against Trypanosoma brucei infections in mice. A wide range of ED50 values was observed among 5-substituted derivatives of 4. The 5-amino analogue 5 and 5-acetamido analogue 6 were about twice as active as 4. 1,3,5-Triacetylbenzene tris(guanylhydrazone) (12) was about 9 times as active as 4 and was approximately one-half as active as the currently used trypanocide diminazene aceturate in this test system. Other 5-derivatives had activity equivalent to or less than that of the parent compound 4. Three new heterocyclic analogues were all less active than 2,6-diacetylpyridine derivative 17 and benzene derivative 4. Ring substitution ortho to the guanylhydrazone side chains was invariably detrimental to activity. Side-chain homologues 1,3-dipentanoylbenzene bis(guanylhydrazone) and 1,3-diacetylbenzene bis(2-imidazolin-2-ylhydrazone) were essentially inactive.

  8. Polyamine metabolism in the kidneys of castrated and testosterone-treated mice after administration of methylglyoxal bis(guanylhydrazone).

    Science.gov (United States)

    Henningsson, S; Persson, L; Rosengren, E

    1979-02-01

    The effects of methylglyoxal bis(guanylhydrazone) on S-adenosyl-L-methionine decarboxylase (EC 4.1.1.50) activity were studied in the mouse kidney stimulated to growth by testosterone administration. The drug was found a potent inhibitor of the enzyme in vitrol Administration of methylglyoxal bis(guanylhydrazone) in vivo resulted in a transient inhibition followed by a strong enhancement of the enzyme activity. Dialysis of the kidney extract, to remove remaining methylglyoxal bis(guanylhydrazone), revealed a great and rapid increase in the activity of S-adenosyl-L-methionine decarboxylase. Injections of testosterone to castrated mice resulted in a marked increase in kidney weight and an accumulation of renal putrescine, spermidine and spermine. These effects of testosterone could not be blocked by simultaneous injections of methylglyoxal bis(guanylhydrazone). It appears that due to secondary effects by which the inhibition of methylglyoxal bis(guanylhydrazone) on S-adenosyl-L-methionine decarboxylase activity is circumvented the inhibitor seems to be of uncertain value in attempts to decrease selectively the in vivo levels of polyamines.

  9. Optimizing complex scandium-3,3 benzilidene BIS [4-hydroxycoumarin] with 46Sc radiotracer

    International Nuclear Information System (INIS)

    Khanza Aktari Dewi; Muhamad Basit Febrian; Duyeh Setiawan

    2015-01-01

    Coumarin, coumarin derivatives and coumarin complex compounds known to possess biological activities such as anticancer and antiviral. The reaction between the active compound coumarin derivatives with radioisotopes Sc-46 is expected to give a complex that will be marked for further investigation of its biological activity in purpose of drug development based on coumarin. This study aims to determine the optimum conditions in the synthesis of its complex compounds as well as the physico chemical characteristics including physical properties and radiochemical purity of the complex. 3.3 benzilidene bis [4-hydroxycoumarin] ligand has successfully synthesized by reacting 4-hydroxycoumarin with benzaldehyde. Complex solids formed instantly when the solution ScCl 3 labeled by Sc-46 with a pH of 5 is reacted with a ligand solution with a pH of 11 with the optimum ratio of Sc: ligand were 1:2 with optimum labeling percentage of 99,75 ± 0,02%. FTIR analysis of complex compounds and ligands show some shift in absorption due to the formation of complex. Melting point of ligand was 234°C whilst complex compound was not yet melted in maximum range of Fischer-Jons instrument at 300°C. The complex was white reddish coloured and well soluble in DMSO. Radiochemical purity of the complex Sc-(3,3 benzilidene bis [4-hydroxycoumarin]) 2 .2H 2 O was 91.22%. Complex compound of coumarin labeled by Sc-46 has been successfully synthesized and characterized with proposed molecular formula of Sc-(3,3 benzilidene bis [4-hydroxycoumarin]) 2 .2H 2 O. (author)

  10. C,C'-bis(benzodiazaborolyl)dicarba-closo-dodecaboranes: synthesis, structures, photophysics and electrochemistry.

    Science.gov (United States)

    Weber, Lothar; Kahlert, Jan; Brockhinke, Regina; Böhling, Lena; Halama, Johannes; Brockhinke, Andreas; Stammler, Hans-Georg; Neumann, Beate; Nervi, Carlo; Harder, Rachel A; Fox, Mark A

    2013-08-14

    Six new C,C'-bis(benzodiazaborolyl)dicarba-closo-dodecaboranes, 1,A-R2-1,A-C2B10H10, where R represents the group 2-(1,3-Et2-1,3,2-N2BC6H4) or 2-(1,3-Ph2-1,3,2-N2BC6H4) and A is 2, 7 or 12, were synthesized from o-, m-, and p-dicarbadodecaboranes (carboranes) by lithiation and subsequent treatment with the respective 2-bromo-1,3,2-benzodiazaboroles. UV-visible and fluorescence spectra of all carboranes display low energy charge transfer emissions. While such emissions with Stokes shifts between 17,330 and 21,290 cm(-1) are typical for C,C'-bis(aryl)-ortho-carboranes, the observed low-energy emissions with Stokes shifts between 8320 and 15,170 cm(-1) for the meta- and para-isomers are unusual as high-energy emissions are typical for meta- and para-dicarbadodecaboranes. Fluorescence quantum yields (φF) for the novel 1,7- and 1,12-bis(benzodiazaborolyl)-carboranes depend on the substituents at the nitrogen atoms of the heterocycle. Thus, the para-carborane with N-ethyl substituents 1,12-(1',3'-Et2-1',3',2'-N2BC6H4)2-1,12-C2B10H10 has a φF value of 41% in cyclohexane solution and only of 9% in the solid state, whereas the analogous 1,12-(1',3'-Ph2-1',3',2'-N2BC6H4)2-1,12-C2B10H10 shows quantum yields of 3% in cyclohexane solution and 72% in the solid state. X-ray crystallographic, computational and cyclic voltammetry studies for these carboranes are also presented.

  11. Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells

    Science.gov (United States)

    Kalapila, Aley G.; Pegg, Anthony E.

    2009-01-01

    The primary function of O6-alkylguanine-DNA alkyltransferase (AGT) is to maintain genomic integrity in the face of damage by both endogenous and exogenous alkylating agents. However, paradoxically, bacterial and mammalian AGTs have been shown to increase cytotoxicity and mutagenicity of dihaloalkanes and other bis-electrophiles when expressed in bacterial cells. We have extended these studies to mammalian cells using CHO cells that lack AGT expression and CHO cells stably transfected with a plasmid that expresses human AGT. The cytotoxicity of 1,2-dibromoethane, dibromomethane and epibromohydrin was significantly increased by the presence of AGT but cytotoxicity of butadiene diepoxide was not affected. Mutations caused by these agents were assessed using hypoxanthine-guanine phosphoribosyltransferase (HPRT) as a reporter gene. There was a small (c. 2–3-fold) but statistically significant AGT-mediated increase in mutations caused by 1,2-dibromoethane, dibromomethane and epibromohydrin. Analysis of the mutation spectrum induced by 1,2-dibromoethane showed that the presence of AGT also altered the types of mutations with an increase in total base substitution mutants due to a rise in transversions at both G:C and A:T sites. AGT expression also led to mutations arising from the transcribed strand, which were not seen in cells lacking AGT. Although the frequency of deletion mutations was decreased by AGT expression, the formation of large deletions (≥3 exons) was increased. This work demonstrates that interaction of AGT with some bis-electrophiles can cause mutagenicity and diminished cell survival in mammalian cells. It is consistent with the hypothesis that DNA-AGT cross-links, which have been characterized in experiments with purified AGT protein and such bis-electrophiles, can be formed in mammalian cells. PMID:19941875

  12. Synthesis of a Bis(thiophenolate)pyridine Ligand and Its Titanium, Zirconium, and Tantalum Complexes

    KAUST Repository

    Lenton, Taylor N.

    2012-11-12

    A precursor to a new tridentate LX 2 type ligand, bis(thiophenol)pyridine ((SNS)H 2 = (2-C 6H 4SH) 2-2,6-C 5H 3N), was prepared. Bis(thiophenolate)pyridine complexes of Ti, Zr, and Ta having dialkylamido coligands were synthesized and structurally characterized. The zirconium complex (SNS)Zr(NMe 2) 2 (4) displays C 2 symmetry in the solid state, unlike a related bis(phenolate)pyridine compound, C s-symmetric (ONO)Ti(NMe 2) 2. This change is likely the result of strain about the sulfur atom in the six-membered chelate with longer metal-sulfur and carbon-sulfur bonds. Solid-state structures of tantalum complexes (SNS)Ta(NMe 2) 3 (5) and (SNS)TaCl(NEt 2) 2 (6) also display pronounced C 2 twisting of the SNS ligand. 1D and 2D NMR experiments show that 5 is fluxional, with rotation about the Ta-N(amide) bonds occurring on the NMR time scale that interchange the equatorial amide methyl groups (ΔG ‡ 393 = 25.0(3) kcal/mol). The fluxional behavior of 6 in solution was also studied by variable-temperature 1H NMR. Observation of separate signals for the diastereotopic protons of the methylene unit of the diethylamide indicates that the complex remains locked on the NMR time scale in one diastereomeric conformation at temperatures below -50 °C, fast rotation about the equatorial amide Ta-N bonds occurs at higher temperature (ΔG ‡ 393 = 13.4(3) kcal/mol), and exchange of diastereomeric methylene protons occurs via inversion at Ta that interconverts antipodes (ΔG ‡ 393 ≈ 14(1) kcal/mol). © 2012 American Chemical Society.

  13. Regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane.

    Science.gov (United States)

    Nakabo, Satoshi; Torii, Yasuhiro; Itota, Toshiyuki; Ishikawa, Kunio; Suzuki, Kazuomi

    2002-01-01

    The aim of this study was to evaluate the feasibility of regulation of NaF release from bis-GMA/TEGDMA resin using gamma-methacryloxypropyltrimethoxysilane (gamma-MPTS). NaF powder was treated with gamma-MPTS to form a polysiloxane layer on its surface. The morphology and the composition of the NaF powder treated with gamma-MPTS were evaluated using scanning electron microscopy, infrared spectroscopy, contact angle measurement and X-ray photoelectron spectroscopy. Bis-GMA/TEGDMA resin containing 50 wt% NaF powder was prepared as a model resin and immersed in distilled water at 37 degrees C, and the amount of fluoride released from the resin was measured using a fluoride electrode. The mechanical strength in terms of diametral tensile strength before and after fluoride release was also measured, and statistically analyzed using one-way factorial ANOVA and Fisher's PLSD method. NaF powder was covered with hydrophobic gamma-MPTS delivered polysiloxane. A larger amount of fluoride was released at the initial stage from the resin containing NaF treated with no gamma-MPTS. However, fluoride release terminated in a relatively shorter period. In contrast, we observed a smaller amount of fluoride released for a longer period from the resin containing NaF treated with gamma-MPTS. We found that gamma-MPTS treatment is useful for the regulation of NaF release from bis-GMA/TEGDMA resin. The mechanism of slow NaF release may be the formation of a hydrophobic polysiloxane layer on the surface of NaF powder and resulting slow water diffusion to NaF powder.

  14. Structural and spectroscopic characterization of five coordinate iron and cobalt bis(dithiolene)-trimethylphosphine complexes

    Science.gov (United States)

    Selby-Karney, Troy; Grossie, David A.; Arumugam, Kuppuswamy; Wright, Eyglo; Chandrasekaran, P.

    2017-08-01

    Heteroleptic bis(dithiolene)-phosphine iron and cobalt complexes [Fe(adt)2(PMe3)] (1) and [Co(adt)2(PMe3)] (2) (adt = para-anisyldithiolene) have been synthesized from corresponding bis(dithiolene) dimers [M2(adt)4]2 (M = Fe, Co) by reacting with excess PMe3 in dichloromethane. Solid-state structures of 1 and 2 have been determined by single crystal X-ray crystallography, and the dithiolene ligands Csbnd S (≈1.72 Å) and Csbnd C (≈1.37 Å) bond distances reveal the coordination of π-radical monoanionic dithiolene (adt•1-) ligands to metal centers. Intense low energy ligand-to-ligand-charge transfer (LLCT) absorption band (743 nm for 1; 905 nm for 2) in UV-vis spectra and characteristic ν(Cdbnd S•) (1168 cm-1 for 1; 1170 cm-1 for 2) in IR spectra affirms coordination of π-radical monoanionic dithiolenes to divalent metal ions. The cyclic voltammogram of 1 and 2 shows reversible oxidation and reduction waves attributed to MII → MIII + e- (+0.52 V for 1; +0.29 V for 2) and adt•1- + e- → adt2- (-0.63 V for 1; -0.46 V for 2) redox process respectively. Comprehensive structural and spectroscopic investigations conclude, [M2III(adt2-)2(adt•1-)2] → 2 [MII(adt•1-)2(PMe3)] intramolecular redox interplay during phosphine coordination induced cleavage of homoleptic bis(dithiolene) dimers to produce square pyramidal complexes.

  15. New discrete and polymeric supramolecular architectures derived from dinuclear (bis-beta-diketonato)copper(II) metallocycles.

    Science.gov (United States)

    Clegg, Jack K; Gloe, Karsten; Hayter, Michael J; Kataeva, Olga; Lindoy, Leonard F; Moubaraki, Boujemaa; McMurtrie, John C; Murray, Keith S; Schilter, David

    2006-09-07

    New examples of adducts between di- (and, in one instance, tetra-) functional nitrogen ligands and planar 'platform-like' dinuclear copper(II) complexes, [Cu2L2], incorporating the 1,3-aryl linked bis-beta-diketonato bridging ligand 1,1'-(1,3-phenylene)-bis(4,4-dimethylpentane-1,3-dione) (H2L) have been synthesised. The X-ray structures of six adduct species are reported. The interaction of [Cu2(L)2] with the ditopic ligand aminopyrazine (apyz) yielded the sandwich-like tetranuclear species [(Cu2L2(apyz))2]. A variable-temperature magnetochemical investigation of this product indicated weak antiferromagnetic coupling between the (five-coordinate) copper centres, mediated by the 2-aminopyrazine linkers. An analogous structure, [(Cu2L2(dabco))2] (dabco=1,4-diazabicyclo[2.2.2]octane), was generated when dabco was substituted for aminopyrazine while use of 4,4'-dipyridyl sulfide (dps) and 4,4'-(1,3-xylylene)-bis(3,5-dimethylpyrazole) (xbp) as the ditopic 'spacer' ligands resulted in polymeric species of type [Cu2L2(dps)]n and [Cu2L2(xbp)]n, respectively. These latter species exist as one-dimensional chain structures in which copper(II) centres on different dinuclear platforms are linked in a 'zigzag' fashion. In contrast, with 2,2'-dipyridylamine (dpa) a discrete complex of type [Cu2L2(dpa)2] formed in which one potential pyridyl donor from each 2,2'-dipyridylamine ligand remains uncoordinated. The use of the potentially quadruply-bridging hexamethylenetetramine (hmt) ligand as the linker unit was found to give rise to an unusual two-dimensional polymeric motif of type [(Cu2(L2)2)3(hmt)2]n. The product takes the form of a (6,3) network, incorporating triply bridging hexamethylenetetramine units.

  16. Synthesis and Photophysical and Electrochemical Properties of Functionalized Mono-, Bis-, and Trisanthracenyl Bridged Ru(II Bis(2,2′:6′,2″-terpyridine Charge Transfer Complexes

    Directory of Open Access Journals (Sweden)

    Adewale O. Adeloye

    2014-01-01

    Full Text Available With the aim of developing new molecular devices having long-range electron transfer in artificial systems and as photosensitizers, a series of homoleptic ruthenium(II bisterpyridine complexes bearing one to three anthracenyl units sandwiched between terpyridine and 2-methyl-2-butenoic acid group are synthesized and characterized. The complexes formulated as bis-4′-(9-monoanthracenyl-10-(2-methyl-2-butenoic acid terpyridyl ruthenium(II bis(hexafluorophosphate (RBT1, bis-4′-(9-dianthracenyl-10-(2-methyl-2-butenoic acid terpyridyl ruthenium(II bis(hexafluorophosphate (RBT2, and bis-4′-(9-trianthracenyl-10-(2-methyl-2-butenoic acid terpyridyl ruthenium(II bis(hexafluorophosphate (RBT3 were characterized by elemental analysis, FT-IR, UV-Vis, photoluminescence, 1H and 13C NMR spectroscopy, and electrochemical techniques by elemental analysis, FT-IR, UV-Vis, photoluminescence, 1H and 13C NMR spectroscopy, and electrochemical techniques. The cyclic voltammograms (CVs of (RBT1, (RBT2, and (RBT3 display reversible one-electron oxidation processes at E1/2 = 1.13 V, 0.71 V, and 0.99 V, respectively (versus Ag/AgCl. Based on a general linear correlation between increase in the length of π-conjugation bond and the molar extinction coefficients, the Ru(II bisterpyridyl complexes show characteristic broad and intense metal-to-ligand charge transfer (MLCT band absorption transitions between 480–600 nm, ε=9.45×103 M−1 cm−1, and appreciable photoluminescence spanning the visible region.

  17. 4-[Bis(4-fluorophenylmethyl]piperazin-1-ium 2-hydroxybenzoate 2-hydroxybenzoic acid monosolvate

    Directory of Open Access Journals (Sweden)

    A. S. Dayananda

    2012-04-01

    Full Text Available The title compound, C17H19F2N2+·C7H5O3−·C7H6O3, is a co-crystal from 4-[bis(4-fluorophenylmethyl]piperazin-1-ium, salicylate anion and salicylic acid in a 1:1:1 ratio. In addition to an intramolecular O—H...O hydrogen bond, the crystal packing shows hydrogen bonds between the piperazinium cation and salicylate anion (N—H...O, as well as between the salicylic acid molecule and anion (O—H...O, giving rise to a three-dimensional network.

  18. Simple, mild, and highly efficient synthesis of 2-substituted benzimidazoles and bis-benzimidazoles

    Energy Technology Data Exchange (ETDEWEB)

    Eren, Bilge, E-mail: bilge.eren@bilecik.edu.tr [Faculty of Science and Arts, Department of Chemistry, Bilecik Seyh Edebali University, (Turkey); Bekdemir, Yunus [Faculty of Science and Arts, Canik Basari University, Samsun (Turkey)

    2014-07-01

    A new convenient method for preparation of 2-substituted benzimidazoles and bis-benzimidazoles is presented. In this method, o-phenylenediamines were condensed with bisulfite adducts of various aldehydes and di-aldehydes under neat conditions by microwave heating. The results were also compared with results of synthesis by conventional heating under reflux. Structures of the products were confirmed by infrared, {sup 1}H- and {sup 13}C-NMR spectroscopy. Short reaction times, good yields, easy purification of products, and mild reaction conditions are the main advantages of this method. (author)

  19. Synthesis and antifungal activity of halogenated aromatic bis-γ-lactones analogous to avenaciolide

    Directory of Open Access Journals (Sweden)

    Pedro A. Castelo-Branco

    2012-01-01

    Full Text Available Here we describe the total syntheses and characterization by elemental analyses, infrared and NMR spectroscopy of three new compounds analogous to avenaciolide, a bis-γ-lactone isolated from Aspergillus avenaceus that possesses antifungal activity, where the octyl group of the natural product was replaced by aromatic groups containing chlorine and fluorine atoms. The effects of the avenaciolide, the novel compounds and their synthetic precursors on mycelia development and conidia germination of Colletotrichum gloeosporioides and Fusarium solani were evaluated in vitro. The title compounds were almost as active as avenaciolide. The absolute structures of the chlorinated analogs were determined by X-ray diffraction analysis.

  20. Diazido{(S-1-phenyl-N,N-bis[(2-pyridylmethyl]ethanamine}copper(II

    Directory of Open Access Journals (Sweden)

    Sankara Rao Rowthu

    2011-07-01

    Full Text Available In the title compound, [Cu(N32(C20H21N3], the CuII ion is coordinated by the three N atoms of the (S-1-phenyl-N,N-bis[(2-pyridylmethyl]ethanamine ligand and two N atoms from two azide anions, resulting in a distorted square-pyramidal environment. A weak intermolecular C—H...N hydrogen-bonding interaction between one pyridine group of the ligand and an azide N atom of an adjacent complex unit gives a one-dimensional chain structure parallel to the c axis.

  1. Bis-ligated Ti and Zr complexes of chelating N-heterocyclic carbenes

    KAUST Repository

    El-Batta, Amer

    2011-07-01

    In this communication we report the synthesis of novel titanium and zirconium complexes ligated by bidentate "salicylaldimine-like" N-heterocyclic carbenes (NHC). Double addition of the NHC chelate to either TiCl4(thf)2 or ZrCl4 forms bis-ligated organometallic fragments with a distorted octahedral geometry. These complexes are rare examples of group IV transition-metal NHC adducts. Preliminary catalytic tests demonstrate that in the presence of methylaluminoxane (MAO) these complexes are useful initiators for the polymerization of ethylene and the copolymerization of ethylene with norbornene and 1-octene. © 2011 Elsevier B.V. All rights reserved.

  2. Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

    Directory of Open Access Journals (Sweden)

    Jongheon Shin

    2012-09-01

    Full Text Available Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

  3. Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds.

    Science.gov (United States)

    Khownium, Kriangsak; Wood, Stewart J; Miller, Kelly A; Balakrishna, Rajalakshmi; Nguyen, Thuan B; Kimbrell, Matthew R; Georg, Gunda I; David, Sunil A

    2006-03-01

    We have shown that lipopolyamines bind to the lipid A moiety of lipopolysaccharide, a constituent of Gram-negative bacterial membranes, and neutralize its toxicity in animal models of endotoxic shock. In an effort to identify non-polyamine scaffolds with similar endotoxin-recognizing features, we had observed an unusually high frequency of hits containing guanylhydrazone scaffolds in high-throughput screens. We now describe the syntheses and preliminary structure-activity relationships in a homologous series of bis-guanylhydrazone compounds decorated with hydrophobic functionalities. These first-generation compounds bind and neutralize lipopolysaccharide with a potency comparable to that of polymyxin B, a peptide antibiotic known to sequester LPS.

  4. New metal-organic complexes based on bis(tetrazole) ligands: Synthesis, structures and properties

    Science.gov (United States)

    Du, Ceng-Ceng; Fan, Jian-Zhong; Wang, Xin-Fang; Zhou, Sheng-Bin; Wang, Duo-Zhi

    2017-04-01

    In this paper, a series of new complexes, [Zn2(HL1)2(H2O)4]·H2O (1), [Co2(HL1)2]·TEA (2), [Co3(HL1)2(H2L1)2(H2O)4]n (3), [Cu(HL1)(H2O)2]n (4), {[Cu5(HL2)2(OH)4(ClO4)2]·4H2O}n (5) and [Cu2(L3)]n (6) were successfully prepared by utilizing three bis(tetrazole) ligands [bis-(1H-tetrazol-5-ylmethyl)-amine (H3L1), bis-(1H-tetrazol-5-ylethyl)-amine (H3L2) and 1,5-bis(5-tetrazolo)-3-thiapentane (H2L3)], all of which have been characterized by elemental analyses, FT-IR spectroscopy, powder X-ray diffraction (PXRD), thermogravimetric analyses as well as single-crystal X-ray diffraction analyses showing different dimensionalities (0D, 1D and 3D). Complexes 1 and 2 are 0D structures, 1 shows a dinuclear structure, 2 displays two crystallographically different mononuclear structures, 1 and 2 are further assembled to form 3D supramolecular framework and 2D supramolecular network by hydrogen-bonding interactions, respectively. Complexes 3, 4 and 5 are 1D structures, 3 features a mononuclear unit and a 1D chain, which are arranged into 3D supramolecular architecture by hydrogen-bonding interactions, 4 presents a zigzag chain, 5 shows an infinite chain structure constructed from pentanuclear Cu(II) subunits and ClO4- anions. Complex 6 exhibits a 3D coordination framework based on cyclic [Cu4(L3)2] dimmer subunits as nodes possessing an 8-connected network topology with the point symbol {424·64}. Further, semiconductor behaviors, the solid-state luminescent properties of the complexes 1-3 and 6 were measured and studied seriously at room temperature.

  5. Bis(Cyclic Alkyl Amino Carbene) Ruthenium Complexes: A Versatile, Highly Efficient Tool for Olefin Metathesis.

    Science.gov (United States)

    Gawin, Rafał; Kozakiewicz, Anna; Guńka, Piotr A; Dąbrowski, Paweł; Skowerski, Krzysztof

    2017-01-19

    The state-of-the-art in olefin metathesis is application of N-heterocyclic carbene (NHC)-containing ruthenium alkylidenes for the formation of internal C=C bonds and of cyclic alkyl amino carbene (CAAC)-containing ruthenium benzylidenes in the production of terminal olefins. A straightforward synthesis of bis(CAAC)Ru indenylidene complexes, which are highly effective in the formation of both terminal and internal C=C bonds at loadings as low as 1 ppm, is now reported. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Conducting polymers of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester

    International Nuclear Information System (INIS)

    Cirpan, A.; Guner, Y.; Toppare, L.

    2004-01-01

    A dipyrrolyl monomer was synthesized via the reaction between 4-pyrrol-1-yl phenol and decanedioyl dichloride. The electrochemical behavior of this monomer was studied. Polymerization of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester (DAPE) was achieved by chemical and constant current electrolyses methods. Copolymerization of DAPE with thiophene was performed by constant potential electrolysis in acetonitrile-tetrabutylammonium tetrafluoroborate (TBAFB), dichloromethane-TBAFB, solvent-electrolyte couples. The chemical structures and properties were investigated by Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, differential scanning calorimetry and thermal gravimetry analysis. The conductivities of the samples were measured by a four-probe technique

  7. Conducting polymers of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester

    Energy Technology Data Exchange (ETDEWEB)

    Cirpan, A.; Guner, Y.; Toppare, L

    2004-05-15

    A dipyrrolyl monomer was synthesized via the reaction between 4-pyrrol-1-yl phenol and decanedioyl dichloride. The electrochemical behavior of this monomer was studied. Polymerization of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester (DAPE) was achieved by chemical and constant current electrolyses methods. Copolymerization of DAPE with thiophene was performed by constant potential electrolysis in acetonitrile-tetrabutylammonium tetrafluoroborate (TBAFB), dichloromethane-TBAFB, solvent-electrolyte couples. The chemical structures and properties were investigated by Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, differential scanning calorimetry and thermal gravimetry analysis. The conductivities of the samples were measured by a four-probe technique.

  8. Synthesis, characterization and antioxidant study of N,N’-bis(2-chlorobenzamidothiocarbonyl)hydrazine

    Energy Technology Data Exchange (ETDEWEB)

    Firdausiah, Syadza; Hasbullah, Siti Aishah; Yamin, Bohari M. [School of Chemical Science and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)

    2015-09-25

    N,N’-bis(2-chlorobenzamidothiocarbonyl)hydrazine was synthesized from 2-chlorobenzoylisothiocyanate and hydrazine in acetone. The compound was characterized by infrared, {sup 1}H and {sup 13}C NMR, and UV-Vis spectroscopies. X-ray crystallography study showed the molecule adopt trans configuration at both N-N and C-N bonds. The compound showed high antioxidant activity, EC{sub 50} of 374.89 µM, compared to ascorbic acid (EC{sub 50} of 561.36 µM)

  9. Synthesis and antifungal activity of new bis-{gamma}-lactones analogous to avenaciolide

    Energy Technology Data Exchange (ETDEWEB)

    Magaton, Andreia da Silva; Rubinger, Mayura M. M.; Macedo Junior, Fernando C. de [Vicosa Univ., MG (Brazil). Dept. de Quimica]. E-mail: mayura@ufv.br; Zambolim, Laercio [Vicosa Univ., MG (Brazil). Dept. de Fitopatologia

    2007-03-15

    In a study of the antifungal activity of selected compounds as potentials agrochemicals, we have prepared and characterized by elemental analyses, infrared and NMR spectroscopies three new bis-{gamma}-lactones analogous to avenaciolide, where the octyl group of this natural product was replaced by heptyl, hexyl and pentyl groups. The effects on the mycelia development and conidia germination of Colletotrichum gloesporioides of these compounds and their synthetic precursors were evaluated in vitro. The title compounds were active in the tested conditions, while all the synthetic precursors were inactive. The preparation and characterization of 15 new synthetic intermediates are also described. (author)

  10. Synthesis and Characterization of the Adducts of Bis(O-ethyldithiocarbonatocopper(II with Substituted Pyridines

    Directory of Open Access Journals (Sweden)

    Gurpreet Kour

    2013-01-01

    Full Text Available Monomeric five coordinated adducts of bis(O-ethyldithiocarbonatocopper(II of general formula [Cu(C2H5OCS22(L], [L = 2-, 3-, 4-methylpyridines and 2-, 3-, 4-ethylpyridines] have been synthesized and characterized by elemental analysis, i.r. and electronic spectroscopy, magnetic and conductivity measurements. Analytical results show that the adducts have 1 : 1 stoichiometry. The adducts were found to be paramagnetic and their magnetic moments at room temperature lie within the 1.81–1.94 B.M. range and this indicates the presence of one unpaired electron. All the adducts have distorted square pyramidal geometry.

  11. Crystal structure of a diaryl carbonate: 1,3-phenylene bis(phenyl carbonate

    Directory of Open Access Journals (Sweden)

    Marina A. Solomos

    2017-12-01

    Full Text Available The whole molecule of the title compound, C20H14O6, is generated by mirror symmetry, the mirror bisecting the central benzene ring. The carbonate groups adopt an s-cis-s-cis conformation, with torsion angles of 58.7 (2 and 116.32 (15°. The crystal structure of 1,3-phenylene bis(phenyl carbonate contains no strong hydrogen bonds, though weak C—H...O and offset π–π interactions are observed, forming layers parallel to the ac plane.

  12. Tax penalty payment and the “non bis in idem” principle

    Directory of Open Access Journals (Sweden)

    Marie Karfíková

    2017-01-01

    Full Text Available The subject. This paper deals with problems related to tax law with a special focus on legalregulation of the tax procedure contained in the Czech Tax Procedure Code. Attention ispaid in particular to tax penalty payments and the “non bis in idem” principle.The purpose to identify ratio between penalty payments in tax procedure and in criminalprocedure in context of “non bis in idem” principle.The methodological basis of the article is analysis of legislation and court practice of Czechrepublic, Austria, European Union, including formal legal analysis, comparative analysis,synthesis, systematic approach.The results and scope of application. The existing case law of the Czech criminal courts andof the Supreme Court was based on the legal opinion that a penalty payment imposed bythe tax administration in a tax procedure constitutes no punishment, i.e. it is no sanction ofcriminal nature, so that even the final (enforceable decision of the tax administration doesnot create a “ne bis in idem”1 barrier in relation to criminal sanctions for the same taxesrelatednon-compliant action (tax evasion in respect of the penalty payment imposed bythe tax administration.Conclusions. It would probably be advisable for the legislation to amend the relevant provisionsof the Tax Procedure Code in a way that the tax authorities concentrate within thelimits of their powers on proper tax collection and that the law enforcement authorities areauthorized to punishments for deliberate tax evasion. A suggested amendment may thereforebe the removal of the penalty payments from the Tax Procedure Code as the defaultinterest itself is sufficient instrument enough to penalize the taxpayers. Another option is to keep the tax penalty payment in the Tax Procedure Code, but its imposition would only be considered after making sure that the result of any criminal proceedings does not constitute a “ne bis in idem” prohibition within the meaning of Art. 40 (5 of the

  13. White organic light-emitting diodes with 9, 10-bis (2-naphthyl) anthracene

    International Nuclear Information System (INIS)

    Guan Yunxia; Niu Lianbin

    2009-01-01

    White organic light-emitting diodes were fabricated by 9, 10-bis (2-naphthyl) anthracene (ADN) doped with Rubrene with a structure of ITO/copper phthalocyanine (CuPc) / NPB /ADN: Rubrene /Alq 3 /CsF/Mg:Ag/Ag. Multilayer organic devices using AND and Rubrene as an emitting layer produced white emissions with good chromaticity and luminous efficiency as high as 5.93 cd/A. This performance can be explained by Foerster energy transfer from the blue-emitting host to the orange-emitting dopant.

  14. Asymmetric Synthesis of Amino-Bis-Pyrazolone Derivatives via an Organocatalytic Mannich Reaction.

    Science.gov (United States)

    Chauhan, Pankaj; Mahajan, Suruchi; Kaya, Uğur; Peuronen, Anssi; Rissanen, Kari; Enders, Dieter

    2017-07-07

    A new series of N-Boc ketimines derived from pyrazolin-5-ones have been used as electrophiles in asymmetric Mannich reactions with pyrazolones. The amino-bis-pyrazolone products are obtained in excellent yields and stereoselectivities by employing a very low loading of 1 mol % of a bifunctional squaramide organocatalyst. Depending on the substitution at position 4 of the pyrazolones, the new protocol allows for the generation of one or two tetrasubstituted stereocenters, including a one-pot version combing the Mannich reaction with a base-mediated halogenation.

  15. Extended three-dimensional supramolecular architectures derived from trinuclear (bis-beta-diketonato)copper(II) metallocycles.

    Science.gov (United States)

    Clegg, Jack K; Lindoy, Leonard F; McMurtrie, John C; Schilter, David

    2006-07-07

    Neutral trinuclear (triangular) copper(II) complexes of type [Cu3L3] incorporating the 1,4-aryl linked bis-beta-diketonato bridging ligands, 1,1-(1,4-phenylene)-bis(butane-1,3-dione) (H2L2), 1,1-(1,4-phenylene)-bis(pentane-1,3-dione) (H2L3) and 1,1-(1,4-phenylene)-bis(4,4-dimethylpentane-1,3-dione) (H2L4) have been demonstrated to react with selected heterocyclic nitrogen donor bases to generate extended supramolecular architectures whose structures have been confirmed by X-ray diffraction. Thus on reaction with 4,4'-bipyridine (bipy), [Cu3(L2)3] yields polymeric structures of type {[Cu3(L2)3(bipy)(THF)] x 2.75THF}n and {[Cu3(L2)3(bipy)(THF)] x bipy x 0.75THF}(n) while with pyrazine (pyz), {[Cu3(L2)3(pyz)] x 0.5THF}n was obtained. Each of these extended structures contain alternating triangle/linker units in a one-dimensional polymeric chain arrangement in which two of the three copper sites in each triangular 'platform' are formally five-coordinate through binding to a heterocyclic nitrogen atom. Interaction of the multifunctional linker unit hexamethylenetetramine (hmt) with [Cu3(L3)3] afforded an unusual, chiral, three-dimensional molecular framework of stoichiometry [Cu3(L3)3(hmt)]n. The latter incorporates the trinuclear units coordinated to three triply bridging hmt units. In marked contrast to the formation of the above structures incorporating bifunctional linker units and five-coordinate metal centres, the trinuclear platform [Cu3(L2)3] reacts with the stronger difunctional base 1,4-diazabicyclo[2.2.2]-octane (dabco) to yield a highly symmetric trigonal columnar species of type {[Cu3(L4)3(dabco)3] x 3H2O}n in which each copper centre is octahedrally coordinated.

  16. Enantiopure Radical Cation Salt Based on Tetramethyl-Bis(ethylenedithio-Tetrathiafulvalene and Hexanuclear Rhenium Cluster

    Directory of Open Access Journals (Sweden)

    Flavia Pop

    2016-01-01

    Full Text Available Electrocrystallization of the (S,S,S,S enantiomer of tetramethyl-bis(ethylenedithio-tetrathiafulvalene donor 1 in the presence of the dianionic hexanuclear rhenium (III cluster [Re6S6Cl8]2− affords a crystalline radical cation salt formulated as [(S-1]2·Re6S6Cl8, in which the methyl substituents of the donors adopt an unprecedented all-axial conformation. A complex set of intermolecular TTF···TTF and cluster···TTF interactions sustain an original tridimensional architecture.

  17. Steric and electronic parameters of a bulky yet flexible N-heterocyclic carbene: 1,3-bis(2,6-bis(1-ethylpropyl)phenyl)imidazol-2-ylidene (IPent)

    KAUST Repository

    Collado, Alba

    2013-06-10

    The free N-heterocyclic carbene IPent (1; IPent = 1,3-bis(2,6-bis(1- ethylpropyl)phenyl)imidazol-2-ylidene) was prepared from the corresponding imidazolium chloride salt (2). The steric and electronic parameters of 1 were determined by synthesis of the gold(I) chloride complex [Au(IPent)Cl] (3) and the nickel-carbonyl complex [Ni(IPent)(CO)3] (4), respectively. 3 and 4 were fully characterized by NMR spectroscopy, elemental analysis, and X-ray diffraction studies on single crystals. © 2013 American Chemical Society.

  18. Preparation of {sup 166} Dy/{sup 166} Ho DTPA-bis biotin as a system of In vivo generator; Preparacion de {sup 166} Dy/{sup 166} Ho DTPA-bis biotina como un sistema de generador In vivo

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez V, M.R

    2003-07-01

    The objective of this work was to synthesize the complex {sup 166} Dy/{sup 166} Ho - diethylen triamine pentaacetic-bis Biotin ({sup 166} Dy/{sup 166} Ho DTPA-bis Biotin) to evaluate its potential as a new radiopharmaceutical in directed radiotherapy. The Dysprosium-166 was obtained for neutron irradiation of {sup 164} Dy{sub 2}0{sub 3} in the TRIGA Mark III reactor. The labelled was carried out in aqueous solution to p H 8.0 for addition of {sup 166} Dy Cl{sub 3} to the diethylen triamine pentaacetic-{alpha}, {omega}-bis Biotin (DTPA-bis Biotin). The radiochemical purity was determined for HPLC and ITLC. The biological integrity of the marked biotin is evaluated by the biological recognition of the avidin for HPLC - molecular exclusion with and without avidin addition. The studies of stability in vitro were made in dilutions of saline solution to 0.9% and with human serum at 37 C incubated 1 and 24 hours. The complex {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin was obtained with a radiochemical purity of 99.1 {+-} 0.6%. The biological recognition of the complex {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin for the avidin it doesn't affect the labelling procedure. The studies in vitro demonstrated that the {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin is stable after the dilution in saline solution and in human serum that there is not translocation of the one radionuclide subsequent son to the beta decay of the {sup 166} Dy that could produce the {sup 166} Ho{sup 3+} liberation. The studies of Biodistribution in healthy mice demonstrated that the one complex {sup 166} Dy/{sup 166} Ho DTPA-bis Biotin have a high renal distribution. In conclusion the radiolabelled biotin in this investigation has the appropriate properties to be used as an In vivo generator system stable for directed radiotherapy. (Author)

  19. Three-step metal-promoted allene-based preparation of bis(heterocyclic) cyclophanes from carbonyl compounds.

    Science.gov (United States)

    Alcaide, Benito; Almendros, Pedro; Quirós, M Teresa; Lázaro, Carlos; Torres, M Rosario

    2014-07-03

    A straightforward metal-mediated method for the synthesis of bis(dihydrofuryl) cyclophane scaffolds from carbonyl compounds has been developed. The combination of the dihydrofuran moiety with different heterocycles such as β-lactams and sugars allows high levels of skeletal diversity. The process comprises indium-promoted one-pot carbonyl bis(allenylation) and gold- or palladium-catalyzed double cyclization in the resulting bis(allenols), followed by selective ruthenium-catalyzed macrocyclization. In some cases, the method has been successfully applied to the synthesis of the challenging Z-isomers. The E- versus Z-stereochemistry of the metathesis-formed double bonds could not be assigned taking into consideration the usual coupling constants criteria, but a diagnostic based on the chemical shifts of the two olefinic protons located at the macrocyclic double bond was established.

  20. Effect of Lead substitution on LaO0.5F0.5BiS2

    Science.gov (United States)

    Otsuki, Satoshi; Demura, Satoshi; Sakai, Yuuto; Fujisawa, Yuita; Sakata, Hideaki

    2018-02-01

    We examined Lead (Pb) Substitution effect on a single crystal of a layered superconductor LaO0.5F0.5BiS2. Pb concentration dependence of the lattice constant showed slight anomaly at about 8% and 9% substitution of Pb for Bi. These samples showed the enhancement of the superconducting transition temperature and the superconducting volume fraction. Furthermore, these samples showed the anomaly in the temperature dependence of the resistivity at about 150 K. These results were not observed in Pb substituted NdO0.7F0.3BiS2. Therefore, the enhancement of the superconducting properties by Pb substitution is related to the structural instability for the pale perturbation in LaO0.5F0.5BiS2.

  1. Interest of bone scintigraphy in the care of maxillary osteo-necroses induced by bis-phosphonates

    International Nuclear Information System (INIS)

    Agossa, Kevimy

    2012-01-01

    First cases of bis-phosphonates related osteonecrosis of jaws (BRONJ) have been described in 2003. Since then, this subject is one of the central concerns of several scientific communities, well beyond the oral sphere. The prevalence of BRONJ is evolving. Their etiology is not well established and the results of the treatments are inconstant. So many points that make the care to patients under bis-phosphonates really complex. Early diagnosis is essential in treatment outcome. So nuclear imaging including scintigraphy with technetium 99m seems to be helpful. It may allow detection before the onset of symptoms, facilitate localization of necrosis and it may be useful for the monitoring of such lesions after surgery. These are new applications for oncologist and dentist, in order to improve the management of patients treated by bis-phosphonates. (author) [fr

  2. Immobilized Bis-Indenyl Ligands for Stable and Cost-Effective Metallocene Catalysts of Hydrogenation and Polymerization Reactions

    Science.gov (United States)

    Simerly, Thomas Max

    Reactions of catalytic hydrogenations and polymerizations are widely used in industry for manufacture of fine chemicals, pharmaceuticals, and plastics. Homogeneous catalysts for the processes that have low stability and their separation is difficult. Therefore, the development of new highly active and stable catalysts for hydrogenations and polymerizations is a necessity. The objective of this research was the development of a strategy for immobilization of heterogeneous metallocene catalysts. First, a methodology of immobilization of bis-indenyl ligands on the surface of mesoporous silica gel was designed. Four bis-indenyl ligands containing functionalized tethers of various lengths with terminal alkene groups were synthesized. All bis-indenyl ligands were immobilized on the surface of mesoporous functionalized silica gel by two methods: hydrosilylation and thiol-ene coupling of the double bond. After comparing the results, the second strategy was chosen as more efficient. The materials can be used further as intermediates for synthesis of supported metallocene catalysts.

  3. Synthesis and optical characterization of ternary chalcogenide Cu3BiS3 thin film by spin coating

    Science.gov (United States)

    Rawal, Neha; Hadi, Mohammed Kamal; Modi, B. P.

    2017-05-01

    In this work, ternary Chalcogenide Cu3BiS3(CBS) thin films have been prepared and modified by using spin coating technique. Lucratively, spin coating technique is easy going and simple though it hasn't given an enclosure and extensive focus of researches for Cu3BiS3 thin films formation. The surface smoothness and the homogeneity of the obtained thin films have been optimized throughout varying the annealing temperature, concentration and rotation speed. It had been found that as prepared films the value of the energy band gap is 1.4 eV, the absorption coefficient 105 cm-1. Each values of the EBG (Energy Band Gap) and AC (Absorption coefficient) was found in quite agreement with the published work of CBS thin film formation by other methods as CBD, dip coating etc. It signifies that Cu3BiS3 films can be used as an absorber layer for thin film solar cell.

  4. Bis[(lprolinate-N,O]Zn: A water-soluble and recycle catalyst for various organic transformations

    Directory of Open Access Journals (Sweden)

    Roona Poddar

    2017-05-01

    Full Text Available Under the green chemistry perspective, bis[(lprolinate-N,O]Zn (also called zinc–proline or Zn[(l-pro]2 has proven its competence as a promising alternative in a plethora of applications such as catalyst or promoter. Owing to its biodegradable and non-toxic nature of bis[(lprolinate-N,O]Zn, it is being actively investigated as a water soluble green catalyst for synthetic chemistry. Bis[(lprolinate-N,O]Zn are readily utilized under mild conditions and have high selectivity and reactivity with broad range of substrate acceptance to make it better reaction medium for a wide variety of organic transformations. This Review summarizes the till date literature on its synthesis, characterization, and its catalytic role in various organic reactions.

  5. A click chemistry approach for the synthesis of mono and bis aryloxy linked coumarinyl triazoles as anti-tubercular agents.

    Science.gov (United States)

    Anand, Ashish; Naik, Reshma J; Revankar, Hrishikesh M; Kulkarni, Manohar V; Dixit, Sheshagiri R; Joshi, Shrinivas D

    2015-11-13

    A series of mono and bis-triazole coumarin hybrids 6a-u and 9a-f respectively have been synthesized using 4-(azidomethyl)-2H-chromen-2-ones 5a-i and aryl propargyl ethers 2a-c/8 employing Click chemistry modified protocol for Azide-Alkyne cycloadditions(CuAAC). Anti-tubercular screening showed moderate activity for mono aryloxy compounds 6a-u with MIC 50-100 μg/mL, whereas the bis compounds 9a-f were more effective with MICs between 0.2 and 12.5 μg/mL. Molecular modeling and 3D-QSAR measurements using CoMFA and Topomer CoMFA further supported the observed results. The bis compound 9b showed excellent activity with MIC value as low as 0.2 μg/mL. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  6. trans-Bis[4-amino-3,5-bis-(2-pyrid-yl)-4H-1,2,4-triazole-κN]diaqua-cobalt(II) bis-(3-carb-oxy-5-nitro-benzoate).

    Science.gov (United States)

    Wang, Xi; Shao, Chun-Fu; Li, Cheng-Peng

    2011-10-01

    The title complex, [Co(C(12)H(10)N(6))(2)(H(2)O)(2)](C(8)H(4)NO(6))(2), is composed of a mononuclear cobalt(II) cation and two 3-carb-oxy-5-nitro-benzoate anions for charge balance. In the cation, the Co(II) atom is six-coordinated in a distorted octa-hedral geometry. It bonds to two O atoms of two water mol-ecules, and two pairs of N atoms from two 4-amino-3,5-bis-(2-pyrid-yl)-4H-1,2,4-triazole mol-ecules, which behave as bidentate chelating ligands. There are intra-molecular N-H⋯N hydrogen bonds in the cation. In the crystal, there are a number of inter-molecular N-H⋯O and O-H⋯O hydrogen bonds, as well as inter-molecular π-π stacking inter-actions [centroid-centroid distances = 3.657 (2) and 3.847 (2) Å], that link the mol-ecules into two-dimensional networks lying parallel to the ab plane. The presence of C-H⋯O inter-actions leads to the formation of a three-dimensional network.

  7. Reactions of Glyceraldehyde 3-Phosphate Dehydrogenase Sulfhydryl Groups with bis-Electrophiles Produce DNA-Protein Crosslinks but Not Mutations

    Science.gov (United States)

    Loecken, Elisabeth M.; Guengerich, F. Peter

    2014-01-01

    The environmental contaminant 1,2-dibromoethane and diepoxybutane, an oxidation product of the important industrial chemical butadiene, are bis-functional electrophiles and known to be mutagenic and carcinogenic. One mechanism by which bis-electrophiles can exert their toxic effects is through the induction of genotoxic and mutagenic DNA–peptide crosslinks. This mechanism has been shown in systems overexpressing the DNA repair protein O6-alkylguanine DNA-alkyltransferase (AGT) or glutathione S-transferase and involves reactions with nucleophilic cysteine residues. The hypothesis that DNA-protein crosslink formation is a more general mechanism for genotoxicity by bis-electrophiles was investigated by screening nuclear proteins for reactivity with model monofunctional electrophiles. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was identified as a candidate due to the nucleophilicity of two cysteine residues (Cys152 and Cys246) in reaction screens with model electrophiles (Dennehy, M. K. et al. (2006) Chem. Res. Toxicol. 19, 20–29). Incubation of GAPDH with bis-electrophiles resulted in inhibition of its catalytic activity, but only at high concentrations of diepoxybutane. In vitro assays indicated DNA-GAPDH crosslink formation in the presence of diepoxybutane, and bis-electrophile reactivity at Cys246 was confirmed using mass spectral analysis. In contrast to AGT, overexpression of human GAPDH in Escherichia coli did not enhance mutagenesis by diepoxybutane. We propose that the lack of mutational enhancement is in part due to the inherently lower reactivity of GAPDH toward bis-electrophiles as well as the reduced DNA binding ability relative to AGT, preventing the in vivo formation of DNA-protein crosslinks and enhanced mutagenesis. PMID:18163542

  8. Comparison of body composition techniques before and after a 161-km ultramarathon using DXA, BIS and BIA.

    Science.gov (United States)

    Hew-Butler, T; Holexa, B T; Fogard, K; Stuempfle, K J; Hoffman, M D

    2015-02-01

    The low cost, ease of application and portability of bioelectrical impedance analysis (BIA) and spectroscopy (BIS) devices make them attractive tools for measuring acute changes in body composition before and after exercise, despite potential limitations from active compartmental fluid shifts. The primary study aim was to evaluate use of dual energy x-ray absorptiometry (DXA) against BIA and BIS in measurements of percent body fat (%BF) and percent total body water (%TBW) before and after prolonged endurance exercise. 10 runners were measured pre-race and at race finish. Significant linear relationships were noted pre-race between DXA vs. BIS for %BF (r(2)=0.76; p<0.01) and %TBW (r(2)=0.74; p<0.01). Significant correlations were noted at race finish between DXA vs. BIS for %BF (r(2)=0.64; p<0.01) and %TBW (r(2)=0.66; p<0.05), but only when one outlier was removed. Limits of agreement (LOA) between DXA vs. BIS were wide for both %BF (mean difference of -3.6, LOA between 5.4 and -12.6) and %TBW (mean difference 2.4, LOA between 0.4 and -4.6). LOA was closer between the DXA vs. BIA with DXA measuring slightly higher than BIA for %BF (mean difference of 0.5, LOA between 2.1 and -3.1) and slightly lower than BIA for %TBW (mean difference 0.3, LOA between 3.3 and -2.7). Linear correlations between DXA vs. BIA were not statistically significant for %BF or %TBW before or after the race. DXA measurement of acute changes in %BF and %TBW are not congruent with BIA or BIS measurements. These 3 techniques should not be utilized interchangeably after prolonged endurance running. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Carbon-Oxygen Bond Cleavage by Bis(imino)pyridine Iron Compounds : Catalyst Deactivation Pathways and Observation of Acyl C-O Bond Cleavage in Esters

    NARCIS (Netherlands)

    Trovitch, Ryan J.; Lobkovsky, Emil; Bouwkamp, Marco W.; Chirik, Paul J.

    2008-01-01

    Investigations into the substrate scope of bis(imino)pyridine iron-catalyzed hydrogenation and [2 pi + 2 pi]. diene cyclization reactions identified C-O bond cleavage as a principal deactivation pathway. Addition of diallyl or allyl ethyl ether to the bis(imino)pyridine iron dinitrogen complex,

  10. Syntheses, crystal structures and antimicrobial activities of 6-coordinate antimony(III) complexes with tridentate 2-acetylpyridine thiosemicarbazone, bis(thiosemicarbazone) and semicarbazone ligands.

    Science.gov (United States)

    Kasuga, Noriko Chikaraishi; Onodera, Kuniaki; Nakano, Saori; Hayashi, Kunihiko; Nomiya, Kenji

    2006-07-01

    Five novel antimony(III) complexes with the mono- and bis(thiosemicarbazone) ligands of 2N1S or 4N2S donor atoms, N'-[1-(2-pyridyl)ethylidene]morpholine-4-carbothiohydrazide (Hmtsc, L1) and bis[N'-[1-(2-pyridyl)ethylidene

  11. Estudio in vitro de la actividad citotóxica de resinas dentales tipo BIS-GMA

    OpenAIRE

    Ríos, M.; Cepero, J.; Krael, R.; Davidenko, N.; González, A.

    2003-01-01

    Las resinas composites se emplean desde hace varias décadas en distintas aplicaciones estomatológicas, volviéndose indispensables para lograr una alta calidad en los servicios modernos. Uno de los monómeros acrílicos más utilizados en estos materiales poliméricos de recubrimiento es el 2-bis-[p-(2-hidroxi-3-metacriloxipropoxi) fenil] propano, conocido comúnmente como Bis- GMA. El conocimiento de las interacciones de estos materiales con el sistema biológico es de vital importan...

  12. Tierärztliche Betreuung von Greifvögeln: Entwicklungen im Zeitraum von 1985 bis 2015

    OpenAIRE

    Hatt, Jean-Michel; Clauss, Marcus

    2016-01-01

    Im Rahmen einer retrospektiven Studie wurden die Patientenakten der an die Klinik für Zoo-, Heim- und Wildtiere der Universität Zürich im Zeitraum von 2009 bis 2015 eingelieferten Greifvögel analysiert und mit den Daten aus einer Studie über den Zeitraum von 1985 bis 1994 verglichen. Im gesamten Zeitraum haben sich die durchschnittlichen Fallzahlen von 55 auf 109 Patienten pro Jahr erhöht. Am meisten Vögel werden in den Monaten Februar sowie Juni/Juli vorgestellt. Chirurgische Probleme war...

  13. Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives

    Directory of Open Access Journals (Sweden)

    Abdullah M. Al-Majid

    2013-12-01

    Full Text Available A simple protocol, involving the green synthesis for the construction of novel bis-pyrimidine derivatives, 3a–i and 4a–e are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%–99%.

  14. PROPIEDADES PSICOMÉTRICAS DE LA ESCALA BIS/BAS EN UNA MUESTRA DE ESTUDIANTES UNIVERSITARIOS MEXICANOS

    OpenAIRE

    Marco Antonio Pulido Rull; Liliana Rivera Fong; Alejandro Fondón Mora; Perla Vázquez Pérez

    2016-01-01

    El objetivo de este trabajo fue determinar la estructura factorial, validez predictiva y consistencia interna de la Escala BIS/BAS de Carver y White en una muestra de estudiantes universitarios mexicanos. Participaron 669 universitarios de la Ciudad de México, quienes contestaron una batería compuesta por la Escala BIS/BAS, la Escala de Tamizaje de Abuso de Cannabis, la escala de tamizaje de abuso de drogas (dast-10) y la Escala de Estrés en Estudiantes Universitarios Revisada (SEEU-R). Los r...

  15. Unique "cradled barbell" complex between a secondary diammonium ion and bis(m-phenylene)-32-crown-10.

    Science.gov (United States)

    Bryant, W S; Guzei, I A; Rheingold, A L; Gibson, H W

    1999-07-15

    [formula: see text] The complexation between N,N'-dibenzyl(m-xylylene)diammonium bis(hexafluorophosphate) (2) and bis(m-phenylene)-32-crown-10 (5) was shown to occur in solution by nuclear magnetic resonance with 1:1 stoichiometry and a Ka value of 189 +/- 19 M-1. A crystal structure of 2:5 revealed a unique 1:1 "exo" or "cradled barbell" complex, instead of the expected pseudorotaxane. This unexpected result illustrates that caution be used in interpreting the results from these types of complexes in the solution and "gas" phases on the basis of crystal structures.

  16. [Bis(TrimethylsilylMethyl]Lithium and -Sodium: Solubility in Alkanes and Complexes with O- and N- Donor Ligands

    Directory of Open Access Journals (Sweden)

    Markus von Pilgrim

    2017-06-01

    Full Text Available In contrast to alkyl compounds of lithium, which play an important role in organometallic chemistry, the corresponding heavier alkali metal compounds are less investigated. These compounds are mostly insoluble in inert solvents or undergo solvolysis in coordinating solvents due to their high reactivity. An exception from this typical behavior is demonstrated by bis(trimethylsilylmethylsodium. This study examines alkane solutions of bis(trimethylsilylmethyllithium and -sodium by NMR spectroscopic and cryoscopic methods. In addition, structural studies by X-ray crystallography of the corresponding compounds coordinated by O- and N- ligands (tetrahydrofuran and tetramethylethylenediamine present possible structural motifs of the uncoordinated compounds in solution.

  17. Topotactic synthesis of a new BiS2-based superconductor Bi2(O,F)S2

    OpenAIRE

    Okada, Tomoyuki; Ogino, Hiraku; Shimoyama, Jun-ichi; Kishio, Kohji

    2015-01-01

    A new BiS2-based superconductor Bi2(O,F)S2 was discovered. This is a layered compound consisting of alternate stacking structure of rock-salt-type BiS2 superconducting layer and fluorite-type Bi(O,F) blocking layer. Bi2(O,F)S2 was obtained as the main phase by topotactic fluorination of undoped Bi2OS2 using XeF2, which is the first topotactic synthesis of an electron-doped superconductor via reductive fluorination. With increasing F-content, a- and c-axis length increased and decreased, respe...

  18. Topotactic synthesis of a new BiS2-based superconductor Bi2(O,F)S2

    Science.gov (United States)

    Okada, Tomoyuki; Ogino, Hiraku; Shimoyama, Jun-ichi; Kishio, Kohji

    2015-02-01

    A new BiS2-based superconductor, Bi2(O,F)S2, was discovered. It is a layered compound consisting of alternately stacked structure of rock-salt-type BiS2 superconducting layers and fluorite-type Bi(O,F) blocking layers. Bi2(O,F)S2 was obtained as the main phase by topotactic fluorination of undoped Bi2OS2 using XeF2. This is the first topotactic synthesis of an electron-doped superconductor via reductive fluorination. With increasing F-content, a- and c-axis lengths increased and decreased, respectively, and Tc increased to 5.1 K.

  19. Tuning the microstructures of decavanadate-based supramolecular hybrids via regularly changing the spacers of bis(triazole) ligands

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Mo; Sun, Wenlong [Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040 (China); Pang, Haijun, E-mail: panghj116@163.com [Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040 (China); Ma, Huiyuan, E-mail: mahy017@163.com [Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040 (China); Yu, Jia [Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040 (China); College of Aerospace and Civil Engineering, Harbin Engineering University, Harbin 150001 (China); Zhang, Zhuanfang; Niu, Ying [Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040 (China); Yin, Mingming [Jiamusi Electric Machine Co., Ltd., 766 Guangfu Road, Jiamusi City 154002 (China)

    2016-03-15

    With tuning the ligands from bte, btp, btb to bth, four new decavanadate-based metal–organic hybrid compounds, [Zn(bte)(H{sub 2}O){sub 4}][Zn{sub 2}(bte)(H{sub 2}O){sub 10}](V{sub 10}O{sub 28})·8H{sub 2}O, [Zn{sub 2}(btp){sub 4}(H{sub 2}O){sub 6}](H{sub 2}V{sub 10}O{sub 28})·4H{sub 2}O, [Zn(H{sub 2}O){sub 6}][Zn{sub 2}(btb){sub 2}V{sub 10}O{sub 28}(H{sub 2}O){sub 6}]·4H{sub 2}O, and [Zn{sub 2}(bth)(H{sub 2}O){sub 10}](H{sub 2}V{sub 10}O{sub 28})·6H{sub 2}O (bte=1,2-bis(1,2,4-triazol-1-yl)ethane, btp=1,3-bis(1,2,4-triazol-1-y1)propane, btb=1,4-bis(1,2,4-triazol-1-y1)butane, bth=1,6-bis(1,2,4-triazol-1-y1)hexane), have been synthesized under conventional conditions. The four compounds represent the first examples of decavanadate-based metal–organic hybrids constructed by Zn–bis(triazole) complexes. Their structural analyses show that the four compounds possess different Zn–bis(triazole) structural motifs and various finally structures, which verifies that regular changing the spacers of ligands is an effective strategy to tuning the structures of polyoxometalate-based hybrids. Also, the electrochemical studies show that the compounds have good electrocatalytic activities towards oxidation of nitrite molecules ascribed to V-centers. - Graphical abstract: Four compounds representing the first examples of V{sub 10}O{sub 28}-based hybrids constructed by Zn–bis(triazole) complexes have been synthesized by changing the spacers of the ligands and their electrocatalytic properties have been investigated. - Highlights: • The first examples of V{sub 10}O{sub 28}-based hybrids constructed by Zn-bis(triazole) complexes. • Verifying that changing the spacers of ligands is a strategy to tuning structures. • Showing good electrocatalytic activities toward oxidation of nitrite molecules.

  20. Tuning the microstructures of decavanadate-based supramolecular hybrids via regularly changing the spacers of bis(triazole) ligands

    International Nuclear Information System (INIS)

    Wang, Mo; Sun, Wenlong; Pang, Haijun; Ma, Huiyuan; Yu, Jia; Zhang, Zhuanfang; Niu, Ying; Yin, Mingming

    2016-01-01

    With tuning the ligands from bte, btp, btb to bth, four new decavanadate-based metal–organic hybrid compounds, [Zn(bte)(H 2 O) 4 ][Zn 2 (bte)(H 2 O) 10 ](V 10 O 28 )·8H 2 O, [Zn 2 (btp) 4 (H 2 O) 6 ](H 2 V 10 O 28 )·4H 2 O, [Zn(H 2 O) 6 ][Zn 2 (btb) 2 V 10 O 28 (H 2 O) 6 ]·4H 2 O, and [Zn 2 (bth)(H 2 O) 10 ](H 2 V 10 O 28 )·6H 2 O (bte=1,2-bis(1,2,4-triazol-1-yl)ethane, btp=1,3-bis(1,2,4-triazol-1-y1)propane, btb=1,4-bis(1,2,4-triazol-1-y1)butane, bth=1,6-bis(1,2,4-triazol-1-y1)hexane), have been synthesized under conventional conditions. The four compounds represent the first examples of decavanadate-based metal–organic hybrids constructed by Zn–bis(triazole) complexes. Their structural analyses show that the four compounds possess different Zn–bis(triazole) structural motifs and various finally structures, which verifies that regular changing the spacers of ligands is an effective strategy to tuning the structures of polyoxometalate-based hybrids. Also, the electrochemical studies show that the compounds have good electrocatalytic activities towards oxidation of nitrite molecules ascribed to V-centers. - Graphical abstract: Four compounds representing the first examples of V 10 O 28 -based hybrids constructed by Zn–bis(triazole) complexes have been synthesized by changing the spacers of the ligands and their electrocatalytic properties have been investigated. - Highlights: • The first examples of V 10 O 28 -based hybrids constructed by Zn-bis(triazole) complexes. • Verifying that changing the spacers of ligands is a strategy to tuning structures. • Showing good electrocatalytic activities toward oxidation of nitrite molecules.

  1. Metal and Ligand Effects on the Construction of Divalent Coordination Polymers Based on bis-Pyridyl-bis-amide and Polycarboxylate Ligands

    Directory of Open Access Journals (Sweden)

    Miao-Ning Chang

    2017-12-01

    Full Text Available Ten coordination polymers constructed from divalent metal salts, polycarboxylic acids, and bis-pyridyl-bis-amide ligands with different donor atom positions and flexibility are reported. They were structurally characterized by single-crystal X-ray diffraction. The ten coordination polymers are as follows: (1 {[Ni(L1(3,5-PDA(H2O3]·2H2O}n (L1 = N,N′-di(3-pyridylsuberoamide, 3,5-H2PDA = 3,5-pyridinedicarboxylic acid; (2 {[Ni2(L12(1,3,5-HBTC2(H2O4]·H2O}n (1,3,5-H3BTC = 1,3,5-benzenetricarboxylic acid; (3 {[Ni(L2(5-tert-IPA(H2O2]·2H2O}n (L2 = N,N′-di(3-pyridyladipoamide, 5-tert-H2IPA = 5-tert-butylisophthalic acid; (4 [Ni(L31.5(5-tert-IPA]n (L3 = N,N′-di(4-pyridyladipoamide; (5 [Co(L1(1,3,5-HBTC(H2O]n; (6 {[Co3(L13(1,3,5-BTC2(H2O2]·6H2O}n; (7 [Cu(L4(AIPA]n (L4 = N,N′-bis(3-pyridinylterephthalamide, H2AIPA = 5-acetamido isophthalic acid; (8 {[Cu(L20.5(AIPA]·MeOH}n; (9 {[Zn(L4(AIPA]·2H2O}n; and (10 {[Zn(L2(AIPA]·2H2O}n. Complex 1 forms a 1D chain and 2 is a two-fold interpenetrated 2D layer with the sql topology, while 3 is a 2D layer with the hcp topology and 4 shows a self-catenated 3D framework with the rare (42·67·8-hxg-d-5-C2/c topology. Different Co/1,3,5-H3BTC ratios were used to prepare 5 and 6, affording a 2D layer with the sql topology and a 2D layer with the (4·852(42(832(8 topology that can be further simplified to an hcp topology. While complex 7 is a 2D layer with the (42·67·8(42·6-3,5L2 topology and 8 is a 2-fold interpenetrated 3D framework with the pcu topology, complexes 9 and 10 are self-catenated 3D frameworks with the (424·64-8T2 and the (44·610·8-mab topologies, respectively. The effects of the identity of the metal center, the ligand isomerism, and the flexibility of the spacer ligands on the structural diversity of these divalent coordination polymers are discussed. The luminescent properties of 9 and 10 and their photocatalytic effects on the degradation of dyes are also investigated.

  2. Gelation or molecular recognition; is the bis-(α,β-dihydroxy esters motif an omnigelator?

    Directory of Open Access Journals (Sweden)

    Peter C. Griffiths

    2010-11-01

    Full Text Available Understanding the gelation of liquids by low molecular weight solutes at low concentrations gives an insight into many molecular recognition phenomena and also offers a simple route to modifying the physical properties of the liquid. Bis-(α,β-dihydroxy esters are shown here to gel thermoreversibly a wide range of solvents, raising interesting questions as to the mechanism of gelation. At gelator concentrations of 5–50 mg ml−1, gels were successfully formed in acetone, ethanol/water mixtures, toluene, cyclohexane and chloroform (the latter, albeit at a higher gelator concentration. A range of neutron techniques – in particular small-angle neutron scattering (SANS – have been employed to probe the structure of a selection of these gels. The universality of gelation in a range of solvent types suggests the gelation mechanism is a feature of the bis-(α,β-dihydroxy ester motif, with SANS demonstrating the presence of regular structures in the 30–40 Å range. A correlation between the apparent rodlike character of the structures formed and the polarity of the solvent is evident. Preliminary spin-echo neutron scattering studies (SESANS indicated the absence of any larger scale structures. Inelastic neutron spectroscopy (INS studies demonstrated that the solvent is largely unaffected by gelation, but does reveal insights into the thermal history of the samples. Further neutron studies of this kind (particularly SESANS and INS are warranted, and it is hoped that this work will stimulate others to pursue this line of research.

  3. Degradation of the blister agent sulfur mustard, bis(2-chloroethyl) sulfide, on concrete

    International Nuclear Information System (INIS)

    Brevett, Carol A.S.; Sumpter, Kenneth B.; Wagner, George W.; Rice, Jeffrey S.

    2007-01-01

    The products formed from the degradation of the blister agent sulfur mustard [bis(2-chloroethyl) sulfide] on concrete were identified using gas chromatography with mass spectrometry detection (GC/MSD), 1 H NMR, 2D 1 H- 13 C NMR and 13 C solid state magic angle spinning (SSMAS) NMR. In situ and extraction experiments were performed. Sulfur mustard was detected in the in situ 13 C SSMAS samples for 12 weeks, whereas less than 5% of the sulfur mustard was detected in extracts from the concrete monoliths after 8 days. Sulfonium ions and (2-chloroethylthio)ethyl ether (T) were observed on the in situ samples after a period of 12 weeks, whereas vinyl species and bis(2-chloroethyl) sulfoxide were observed in the extracts of the concrete monoliths within 24 h. The differences between the extraction and the SSMAS data indicated that the sulfur mustard existed in the concrete in a non-extractable form prior to its degradation. Extraction methods alone were not sufficient to identify the products; methods to identify the presence of non-extractable degradation products were also required

  4. Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents.

    Science.gov (United States)

    Ibrahim, Hany S; Abou-Seri, Sahar M; Ismail, Nasser S M; Elaasser, Mahmoud M; Aly, Mohamed H; Abdel-Aziz, Hatem A

    2016-01-27

    Many bis-isatins and isatins with hydrazide extension were reported to have a potential anti-proliferative effects against different cancer cell lines and cancer targets. In this study, four series of bis-isatins with hydrazide linkers were synthesized. These compounds were investigated for their antitumor activity by assessing their cytotoxic potency against HepG2, MCF-7 and HCT-116 cancer cell lines. Compound 21c possessed significant cytotoxic activity against MCF-7 (IC50 = 1.84 μM) and HCT-116 (IC50 = 3.31 μM) that surpasses the activity of doxorubicin against both cell lines (MCF-7; IC50 = 2.57 μM and HCT-116; IC50 = 3.70 μM). Cell cycle analysis and annexin V-FITC staining of MCF-7 cells treated with 21c suggested that the cytotoxic effect of the compound could be attributed to its pro-apoptotic activity. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  5. The cephalostatins. 22. synthesis of bis-steroidal pyrazine pyrones (1).

    Science.gov (United States)

    Pettit, George R; Moser, Bryan R; Mendonça, Ricardo F; Knight, John C; Hogan, Fiona

    2012-06-22

    Cephalostatin 1 (1), a remarkably strong cancer cell growth inhibitory trisdecacyclic, bis-steroidal pyrazine isolated from the marine tube worm Cephalodiscus gilchristi, continues to be an important target for practical total syntheses and a model for the discovery of less complex structural modifications with promising antineoplastic activity. In the present study, the cephalostatin E and F rings were greatly simplified by replacement at C-17 with an α-pyrone (in 12), typical of the steroidal bufodienolides, and by a dihydro-γ-pyrone (in 16). The synthesis of pyrazine 12 from 5α-dihydrotestosterone (nine steps, 8% overall yield) provided the first route to a bis-bufadienolide pyrazine. Dihydro-γ-pyrone 16 was synthesized in eight steps from ketone 13. While only insignificant cancer cell growth inhibitory activity was found for pyrones 12 and 16, the results provided further support for the necessity of more closely approximating the natural D-F ring system of cephalostatin 1 in order to obtain potent antineoplastic activity.

  6. Differential relationships between sub-traits of BIS-11 impulsivity and executive processes: an ERP study.

    Science.gov (United States)

    Kam, Julia W Y; Dominelli, Rachelle; Carlson, Scott R

    2012-08-01

    There is mixed evidence for a relationship between impulsivity and executive functions. Although impulsivity is heterogeneous, previous research did not examine partial relationships controlling for shared variance across sub-traits to evaluate the specificity of these associations. Eighty-five undergraduates completed the Barratt Impulsiveness Scale-11 (BIS-11) and the AX-expectancy version of the Continuous Performance Task (AX-CPT). This task engenders a conflict between two response tendencies by manipulating the frequency of specific trial types. We conducted mixed model analyses to determine the unique variance in behavioral and electrophysiological indices of relevant cognitive functions accounted for by the facets of BIS-11. Motor Impulsiveness was associated with smaller P3 across sites and conditions suggesting a general cognitive limitation not specific to the condition requiring the most inhibition, and larger N2 in some conditions indicating heightened conflict detection. Non-Planning Impulsiveness was related to smaller N2 when inhibiting a primed response and with greater P3 in some contexts. Attentional Impulsiveness appeared to be associated with an inefficient conflict detection system indicated by relatively normal engagement in trials involving the non-potent response, but relatively over engagement in the prepotent condition. Our findings suggest that sub-traits of impulsivity are differentially related to executive processes. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. S-adenosylmethionine decarboxylase inhibitors: new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone).

    Science.gov (United States)

    Stanek, J; Caravatti, G; Capraro, H G; Furet, P; Mett, H; Schneider, P; Regenass, U

    1993-01-08

    A series of 3-acylbenzamidine (amidino)hydrazones 7a-h, the corresponding (hetero)aromatic congeners 7i-p, and 3,3'-bis-amidino-biaryls 25a-e were synthesized. The hydrazones 7a-p were prepared by conversion of the corresponding acyl nitriles 1a,c-d,i,n-p to the imido esters 3a,c-d,i and the amidines 5a,c-d,h-i, followed by a reaction with aminoguanidine, or vice versa. Similarly, the biaryl 3,3'-dinitriles 23a-e were converted, via the imino esters 24a-c or the imino thioesters 27d-e, to the diamidines 25a-e. These new products are conformationally constrained analogues of methylglyoxal bis(guanylhydrazone) (MGBG). They are up to 100 times more potent as inhibitors of rat liver S-adenosylmethionine decarboxylase (SMDC) and generally less potent inhibitors of rat small intestine diamine oxidase (DAO) than MGBG. Some of these SAMDC inhibitors, e.g., compounds 7a, 7e, 7i, 25a, and 25d, have shown antiproliferative effects against T24 human bladder carcinoma cells. These products, whose structure-activity relationships are discussed, are of interest as potential anticancer agents and drugs for the treatment of protozoal and Pneumocystis carinii infections.

  8. Determination of methylglyoxal-bis(guanylhydrazone) in body fluids by ion-pair chromatography.

    Science.gov (United States)

    Roboz, J; Wu, K T; Hart, R D

    1980-01-01

    Methylglyoxal-bis(guanylhydrazone), Methyl-G, is a potent antineoplastic agent currently undergoing Phase l clinical trials. Serum, ascitic and pleural fluids, and urine are deproteinized with methanol, supernatant is evaporated, residue is redissolved in the eluent, lipids are removed with carbon tetrachloride, and an aliquot of the aqueous layer injected into the chromatograph. Ethylglyoxal-bis(guanylhydrazone) (Ethyl-G) is the internal standard. The mobile phase is a mixture of an aqueous buffer (containing 0.004 M heptane and pentane sulfonic acid, 90%:10%, buffered to pH 3.5) and methanol (68%:32%). The ion-pair complex is retained on a micro Bondapak C18 column, eluted with a flow of 2.0 mL/min. Absorbance is measured at 280 nm. Detectability: 30 ng/mL (0.11 micro M) in serum, ascitic and pleural fluids, 300 ng/mL (1.1 micro M) in urine. Calibration curves (peak height ratios of Methyl-G/Ethyl-G plotted against known drug concentrations) were linear in the 0.1-30 microg/mL range. Correlation coefficinets were 0.999; coefficients of variation for reproducibility were less than 5%. Residual blood levels of Methyl-G persist for several days. Methyl-G was found to pass into ascitic fluid.

  9. Conformational study of glyoxal bis(amidinohydrazone) by ab initio methods

    Science.gov (United States)

    Mannfors, B.; Koskinen, J. T.; Pietilä, L.-O.

    1997-08-01

    We report the first ab initio molecular orbital study on the ground state of the endiamine tautomer of glyoxal bis(amidinohydrazone) (or glyoxal bis(guanylhydrazone), GBG) free base. The calculations were performed at the following levels of theory: Hartree-Fock, second-order Møller-Plesset perturbation theory and density functional theory (B-LYP and B3-LYP) as implemented in the Gaussian 94 software. The standard basis set 6-31G(d) was found to be sufficient. The default fine grid of Gaussian 94 was used in the density functional calculations. Molecular properties, such as optimized structures, total energies and the electrostatic potential derived (CHELPG) atomic charges, were studied as functions of C-C and N-N conformations. The lowest energy conformation was found to be all- trans, in agreement with the experimental solid-state structure. The second conformer with respect to rotation around the central C-C bond was found to be the cis conformer with an MP2//HF energy of 4.67 kcal mol -1. For rotation around the N-N bond the energy increased monotonically from the trans conformation to the cis conformation, the cis energy being very high, 22.01 kcal mol -1 (MP2//HF). The atomic charges were shown to be conformation dependent, and the bond charge increments and especially the conformational changes of the bond charge increments were found to be easily transferable between structurally related systems.

  10. Synthesis and structure of Bis(3,3-dimethyl-3,4-dihydroisoquinolyl-1) ketoxime

    International Nuclear Information System (INIS)

    Sokol, V.I.; Davydov, V.V.; Shklyaev, Yu.V.; Kartashova, I.V.; Sergienko, V.S.; Zaitsev, B.E.

    1997-01-01

    The reaction of bis(3,3-dimethyl-3,4-dihydroisoquinolyl-1)methane with NaNO 2 resulted in the formation of bis(3,3-dimethyl-3,4-dihydroisoquinolyl-1) ketoxime (I). The crystal and molecular structure of I was determined (x-ray structure analysis, Enraf-Nonius CAD-4, MoK α -radiation, graphite monochromator, θ/2θ scan, 2θ max =58 deg. , 4800 unique reflections; a=10.327(4), b=9.070(5), and c=21.62(1) A; β=94.02(3) deg.; V=2020(1) A 3 ; Z=4; and sp. gr. Pn). In the crystal, I exists in the oxime tautomeric form. Two symmetry-independent molecules are bound into a dimer through the intermolecular N=OH···N cycl 3 hydrogen bond. Both molecules are nonplanar; the dihedral angles between the mean planes of their 3,4-dihydroisoquinoline moieties are 72 deg. and 74 deg. According to IR and electron absorption spectra, the tautomeric form of compound I is also retained in solutions, and the π-conjugation between the 3,4-dihydroisoquinoline fragments of I is actually absent

  11. Bis(pinacolato)diboron as an additive for the detection of thermal neutrons in plastic scintillators

    International Nuclear Information System (INIS)

    Mahl, Adam; Yemam, Henok A.; Stuntz, John; Remedes, Tyler; Sellinger, Alan; Greife, Uwe

    2016-01-01

    A readily available and inexpensive boron compound was tested as an additive for the detection of thermal neutrons in plastic scintillators. Bis(pinacolato)diboron (B 2 Pin 2 ) was determined to be a compatible boron source (8.51 wt% boron, 1.70 wt% 10 B) in poly(vinyltoluene) based matrices. Plastic scintillator blends of 1–20 wt% 2,5-diphenyloxazole (PPO), 0.1 wt% 1,4-bis(5-phenyloxazol-2-yl) benzene (POPOP) and 1–15 wt% B 2 Pin 2 were prepared that provided optical clarity, good mechanical properties, and the capability of thermal neutron detection. Independent of B 2 Pin 2 concentration, strong 10 B neutron capture signals around 90 keV ee were observed at essentially constant light output. Increasing PPO concentration allowed for the use of pulse shape discrimination (PSD) in both fast and thermal neutron detection. High PPO concentrations appear to cause additional alpha quenching that affected the 10 B neutron capture signal. Aging effects after storage in air for several months were observed, which led to degradation of performance and in some samples of mechanical stability.

  12. Degradation of the blister agent sulfur mustard, bis(2-chloroethyl) sulfide, on concrete

    Energy Technology Data Exchange (ETDEWEB)

    Brevett, Carol A.S. [GEO-CENTERS Operations, SAIC, Gunpowder Branch, P.O. Box 68, APG, MD 21010-0068 (United States)]. E-mail: carol.brevett@us.army.mil; Sumpter, Kenneth B. [CDR USA RDECOM, ATTN: AMSRD-ECB-RT-PD, 5183 Blackhawk Road, Aberdeen Proving Ground, MD 21010-5424 (United States)]. E-mail: kenneth.sumpter@us.army.mil; Wagner, George W. [CDR USA RDECOM, ATTN: AMSRD-ECB-RT-PD, 5183 Blackhawk Road, Aberdeen Proving Ground, MD 21010-5424 (United States)]. E-mail: george.wagner@us.army.mil; Rice, Jeffrey S. [CDR USA RDECOM, ATTN: AMSRD-ECB-RT-PD, 5183 Blackhawk Road, Aberdeen Proving Ground, MD 21010-5424 (United States)]. E-mail: jeffrey.rice@us.army.mil

    2007-02-09

    The products formed from the degradation of the blister agent sulfur mustard [bis(2-chloroethyl) sulfide] on concrete were identified using gas chromatography with mass spectrometry detection (GC/MSD), {sup 1}H NMR, 2D {sup 1}H-{sup 13}C NMR and {sup 13}C solid state magic angle spinning (SSMAS) NMR. In situ and extraction experiments were performed. Sulfur mustard was detected in the in situ {sup 13}C SSMAS samples for 12 weeks, whereas less than 5% of the sulfur mustard was detected in extracts from the concrete monoliths after 8 days. Sulfonium ions and (2-chloroethylthio)ethyl ether (T) were observed on the in situ samples after a period of 12 weeks, whereas vinyl species and bis(2-chloroethyl) sulfoxide were observed in the extracts of the concrete monoliths within 24 h. The differences between the extraction and the SSMAS data indicated that the sulfur mustard existed in the concrete in a non-extractable form prior to its degradation. Extraction methods alone were not sufficient to identify the products; methods to identify the presence of non-extractable degradation products were also required.

  13. Synthesis, chemical and biological properties of the new mono- and bis-derivatives of imidazoles

    Directory of Open Access Journals (Sweden)

    E. V. Welchinska

    2014-12-01

    Full Text Available The aim of research. The problem of finding effective antitumour medical preparation with low toxicity is an important issue of medical and pharmaceutical chemistry. Knowledge of cancer cell features and its metabolism enables to predict the direction of chemical and biological research, to conduct a targeted synthesis of potential drugs, and to assess their applicability in oncological practice as antitumor agents. The purpose of work is to explain preformed heterocycles as purines, its synthesis and investigation of chemical and biological properties. After construction of the potential active structures we proposed the new method of original derivatives synthesis which are received on the base of imidazole, from one side, and fluorocontaining common anesthetic halothane (2-bromo-1,1,1-trifluoro-2-chloroethane from other side. Molecular complex of more perspective biologically active bis-imidazole with antitumour bacterial lectine has been received. With the purpose to synthesize potential antitumour compounds on the base of halothane and imidazole, new convenient methods for the preparation of original heterocyclic derivatives of imidazole have been described. The structure and composition of synthesized compound has been confirmed by the methods of elemental analysis, IR- and NMRІН-spectra. Materials and methods. The majority of the absolute organic solvents (benzene, dimethylformamide, ethyl ester employed in the present studies were distilled before their use. Organic solvents were dried over anhydrous magnesium sulfate or metallic sodium. Gas-liquid chromatography was carried out by Perkin Elmer chromatograph with UV-detector ("Perkin", Germany. IR spectra were recorded in a UR-20 spectrometer ("Charles Ceise Hena", Germany. The 1HNMR spectra were recorded in DMSO-d6 on a 200 MHz BrakerWP-200 ("Braker", Switzerland or Varian T-60 spectrometer ("Varian", USA. Investigation of critical toxicity of new compounds was carried out at

  14. Bacterial RuBisCO is required for efficient Bradyrhizobium/Aeschynomene symbiosis.

    Directory of Open Access Journals (Sweden)

    Benjamin Gourion

    Full Text Available Rhizobia and legume plants establish symbiotic associations resulting in the formation of organs specialized in nitrogen fixation. In such organs, termed nodules, bacteria differentiate into bacteroids which convert atmospheric nitrogen and supply the plant with organic nitrogen. As a counterpart, bacteroids receive carbon substrates from the plant. This rather simple model of metabolite exchange underlies symbiosis but does not describe the complexity of bacteroids' central metabolism. A previous study using the tropical symbiotic model Aeschynomene indica/photosynthetic Bradyrhizobium sp. ORS278 suggested a role of the bacterial Calvin cycle during the symbiotic process. Herein we investigated the role of two RuBisCO gene clusters of Bradyrhizobium sp. ORS278 during symbiosis. Using gene reporter fusion strains, we showed that cbbL1 but not the paralogous cbbL2 is expressed during symbiosis. Congruently, CbbL1 was detected in bacteroids by proteome analysis. The importance of CbbL1 for symbiotic nitrogen fixation was proven by a reverse genetic approach. Interestingly, despite its symbiotic nitrogen fixation defect, the cbbL1 mutant was not affected in nitrogen fixation activity under free living state. This study demonstrates a critical role for bacterial RuBisCO during a rhizobia/legume symbiotic interaction.

  15. Bis-mixed-carbene ruthenium-thiolate-alkylidene complexes: synthesis and olefin metathesis activity.

    Science.gov (United States)

    Dahcheh, Fatme; Stephan, Douglas W

    2015-01-28

    A series of bis-carbene Ru-hydride species, including (IMes)(Im(OMe)2)(PPh3)RuHCl (1) and (SIMes)(Me2Im(OMe)2)(PPh3)RuHCl (2) were prepared and subsequently shown to react with aryl-vinyl-sulfides to give the bis-carbene-alkylidene complexes: Im(OMe)2(SIMes)RuCl(SR)(=CHCH3) (R = p-FC6H4 (3), p-(NO2)C6H4 (4)), Im(OMe)2(IMes)RuCl(=CHCH3)(SPh) (5), Me2Im(OMe)2(SIMes)RuCl(=CHCH3)(SPh) (6), Im(OMe)2(SIMes)(F5C6S)RuCl(=CHR) (R = C4H9 (9), C5H11 (10)). The activity of these species in the standard Grubbs' tests for ring-opening metathesis polymerization, ring-closing and cross-metathesis are reported. Although these thiolate derivatives are shown to exhibit modest metathesis activities, the reactivity is enhanced in the presence of BCl3.

  16. The general properties of water - nitrobenzene - crown - bis-1,2-dicarbollylcobaltate extraction systems

    International Nuclear Information System (INIS)

    Vanura, P.

    2003-01-01

    The extraction and stability constants in the system water - nitrobenzene have been collected and general rules valid for water - nitrobenzene - crown - bis-1,2-dicarbollylcobaltate extraction system have been found. The main principles are size compatibility of ion diameter and crown cavity diameters, the flexibility of crown, the basicity of crown and the steric factor of both the ligand and the extracted ion. The extraction in the system water - mineral acid or salt polyoxyethylene compound - bis-1,2-dicarbollylcobaltate - nitrobenzene is more complicated than can be expected from usually used ion diameter - crown cavity diameter compatibility principle. The other important factors are the basicity and the deformability of crown, steric aspect and the angles of bonds of extracted ion. The binuclear 'sandwich' complexes with H + ion and Sr 2+ or Ba 2+ ions have been proved for dibenzo-18-crown-6 (DB18C6). On the other hand, only SrL 2 and BaL 2 (L = 15C5) complexes are formed in nitrobenzene saturated with water. The addition of polyoxyethylene compound usually increases the distribution ratio of alkali earth metal ions and the selectivity of its mutual separation. (authors)

  17. Bis(pinacolato)diboron as an additive for the detection of thermal neutrons in plastic scintillators

    Energy Technology Data Exchange (ETDEWEB)

    Mahl, Adam [Department of Physics and the Nuclear Science and Engineering Center (NuSEC), Colorado School of Mines, Golden, CO 80401 (United States); Yemam, Henok A.; Stuntz, John [Department of Chemistry and Geochemistry and the Materials Science Program Colorado School of Mines, Golden, CO 80401 (United States); Remedes, Tyler [Department of Physics and the Nuclear Science and Engineering Center (NuSEC), Colorado School of Mines, Golden, CO 80401 (United States); Sellinger, Alan [Department of Chemistry and Geochemistry and the Materials Science Program Colorado School of Mines, Golden, CO 80401 (United States); Greife, Uwe, E-mail: ugreife@mines.edu [Department of Physics and the Nuclear Science and Engineering Center (NuSEC), Colorado School of Mines, Golden, CO 80401 (United States)

    2016-04-21

    A readily available and inexpensive boron compound was tested as an additive for the detection of thermal neutrons in plastic scintillators. Bis(pinacolato)diboron (B{sub 2}Pin{sub 2}) was determined to be a compatible boron source (8.51 wt% boron, 1.70 wt% {sup 10}B) in poly(vinyltoluene) based matrices. Plastic scintillator blends of 1–20 wt% 2,5-diphenyloxazole (PPO), 0.1 wt% 1,4-bis(5-phenyloxazol-2-yl) benzene (POPOP) and 1–15 wt% B{sub 2}Pin{sub 2} were prepared that provided optical clarity, good mechanical properties, and the capability of thermal neutron detection. Independent of B{sub 2}Pin{sub 2} concentration, strong {sup 10}B neutron capture signals around 90 keV{sub ee} were observed at essentially constant light output. Increasing PPO concentration allowed for the use of pulse shape discrimination (PSD) in both fast and thermal neutron detection. High PPO concentrations appear to cause additional alpha quenching that affected the {sup 10}B neutron capture signal. Aging effects after storage in air for several months were observed, which led to degradation of performance and in some samples of mechanical stability.

  18. Bis(pinacolato)diboron as an additive for the detection of thermal neutrons in plastic scintillators

    Science.gov (United States)

    Mahl, Adam; Yemam, Henok A.; Stuntz, John; Remedes, Tyler; Sellinger, Alan; Greife, Uwe

    2016-04-01

    A readily available and inexpensive boron compound was tested as an additive for the detection of thermal neutrons in plastic scintillators. Bis(pinacolato)diboron (B2Pin2) was determined to be a compatible boron source (8.51 wt% boron, 1.70 wt% 10B) in poly(vinyltoluene) based matrices. Plastic scintillator blends of 1-20 wt% 2,5-diphenyloxazole (PPO), 0.1 wt% 1,4-bis(5-phenyloxazol-2-yl) benzene (POPOP) and 1-15 wt% B2Pin2 were prepared that provided optical clarity, good mechanical properties, and the capability of thermal neutron detection. Independent of B2Pin2 concentration, strong 10B neutron capture signals around 90 keVee were observed at essentially constant light output. Increasing PPO concentration allowed for the use of pulse shape discrimination (PSD) in both fast and thermal neutron detection. High PPO concentrations appear to cause additional alpha quenching that affected the 10B neutron capture signal. Aging effects after storage in air for several months were observed, which led to degradation of performance and in some samples of mechanical stability.

  19. Organometallic mediated radical polymerization of vinyl acetate using bis(imino)pyridine vanadium trichloride complexes.

    Science.gov (United States)

    Perry, Mitchell R; Allan, Laura E N; Decken, Andreas; Shaver, Michael P

    2013-07-07

    The synthesis and characterization of one novel proligand and six novel vanadium(III) trichloride complexes is described. The controlled radical polymerization activity towards vinyl acetate of these, and eight other bis(imino)pyridine vanadium trichloride complexes previously reported, is investigated. Those complexes possessing variation at the N-aryl para-position with no steric protection offered by ortho-substituents (4 examples) result in poor control over poly(vinyl acetate) polymerization. Control is improved with increasing steric bulk at the ortho-position of the N-aryl substituent (4 examples) although attempts to increase steric bulk past isopropyl were unsuccessful. Synthesizing bis(imino)pyridine vanadium trichloride complexes with substituted imine backbones restores polymerization control when aliphatic substituents are used (4 examples) but ceases to make any drastic improvements on catalyst lifetime. Modification of the polymerization conditions is also investigated, in an attempt to improve the catalyst lifetime. Expansion of the monomer scope to include other vinyl esters, particularly those derived from renewable resources, shows promising results.

  20. A tetrasilver(Iditungsten(VI cluster with sulfide and bis(diphenylphosphinomethane ligands

    Directory of Open Access Journals (Sweden)

    Cun-Lin Zhang

    2010-10-01

    Full Text Available The asymmetric unit of the title complex, [Ag4W2S8(C25H22P23]·2C3H7NO, tris[μ2-bis(diphenylphosphinomethane]-3:6κ2P:P′;4:5κ2P:P′;5:6κ2P:P′-μ5-sulfido-2:3:4:5:6κ5S-μ3-sulfido-1:3:4κ3S-tetra-μ2-sulfido-1:3κ2S;1:4κ2S;2:5κ2S;2:6κ2S-disulfido-1κS,2κS-tetrasilver(Iditungsten(VI N,N-dimethylformamide disolvate, contains two [WS4]2− anions, four silver cations, three bidentate–bridging bis(diphenylphosphinomethane (dppm ligands and two N,N-dimethylformamide (DMF solvent molecules. The coordination geometry of each Ag atom is distorted tetrahedral. Two Ag ions are coordinated by μ2-S and μ5-S atoms, and by two P atoms from two dppm ligands, while the other two Ag atoms are coordinated by μ2-S, μ3-S and μ5-S atoms, and by one P atom from a dppm ligand.

  1. Relationship between suicide ideation and Behavioral Inhibition/Activation Systems (BIS/BAS and perfectionism

    Directory of Open Access Journals (Sweden)

    Mansour Bairami

    2015-03-01

    Full Text Available Background: The present research investigated the relationship between suicide ideation and Behavioral Inhibition/Activation Systems (BIS/BAS and perfectionism in university Studants. Methods: This descriptive-correlational study was conducted on200 students at university of Tabriz that were selected by multistage cluster sampling. The subjects answered three questionnaires: Beck Scale for Suicide Ideation (BSSI, Multidimensional Perfectionism Scale (MPS and Gray-Wilson Personality Questionnaire (GWPQ. Data were analyzed by Pearson correlation and multiple regression. Results: Results showed that there is a significant relationship between suicide ideation and behavioral inhibition system (R=0/55, self-oriented perfectionism(R=0/40 and socially- prescribed perfectionism (0/47 (p=0.01. Also, the results of regression analysis showed that behavioral inhibition system, self-oriented and socially-prescribed perfectionism could significantly predict suicide ideation. Conclusion: Behavioral activation system (BIS and self-oriented /socially prescribed perfectionism were correlated to and could predict suicide ideation.

  2. Successful Coupling of a Bis-Amidoxime Uranophile with a Hydrophilic Backbone for Selective Uranium Sequestration

    Energy Technology Data Exchange (ETDEWEB)

    Piechowicz, Marek [Department of Chemistry, University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637, United States; Abney, Carter W. [Oak Ridge National Laboratory, P.O. Box 2008, MS-6201, Oak Ridge, Tennessee 37831-6181, United States; Thacker, Nathan C. [Department of Chemistry, University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637, United States; Gilhula, James C. [Department of Chemistry, University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637, United States; Wang, Youfu [Department of Chemistry, University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637, United States; Shanghai Key Laboratory of Advanced Polymeric; Veroneau, Samuel S. [Department of Chemistry, University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637, United States; Hu, Aiguo [Shanghai Key Laboratory of Advanced Polymeric; Lin, Wenbin [Department of Chemistry, University of Chicago, 929 E. 57th Street, Chicago, Illinois 60637, United States

    2017-08-10

    The amidoxime group (-RNH2NOH) has long been used to extract uranium from seawater on account of its high affinity toward uranium. The development of tunable sorbent materials for uranium sequestration remains a research priority as well as a significant challenge. Herein, we report the design, synthesis, and uranium sorption properties of bis-amidoxime-functionalized polymeric materials (BAP 1–3). Bifunctional amidoxime monomers were copolymerized with an acrylamide cross-linker to obtain bis-amidoxime incorporation as high as 2 mmol g–1 after five synthetic steps. The resulting sorbents were able to uptake nearly 600 mg of uranium per gram of polymer after 37 days of contact with a seawater simulant containing 8 ppm uranium. Moreover, the polymeric materials exhibited low vanadium uptake with a maximum capacity of 128 mg of vanadium per gram of polymer. This computationally predicted and experimentally realized selectivity of uranium over vanadium, nearly 5 to 1 w/w, is one of the highest reported to date and represents an advancement in the rational design of sorbent materials with high uptake capacity and selectivity.

  3. Biochemical and chemical characterization of phenylglyoxal bis(guanylhydrazone), an aromatic analogue of mitoguazone.

    Science.gov (United States)

    Elo, H; Koskinen, M; Mutikainen, I; Tilus, P; Lampio, A; Keso, L; Vainio, A; Joutsjoki, V; Alli, K; Yliniva, A

    1996-10-01

    Since little has been known about the properties of aromatic analogues of the antineoplastic agent methylglyoxal bis(guanylhydrazone) (MGBG), an investigation was performed on phenylglyoxal bis(guanylhydrazone) (PhGBG). PhGBG competitively inhibited yeast adenosylmethionine decarboxylase (AdoMetDC) with a Ki of 65 microM. As compared to MGBG (Ki 0.23 microM), PhGBG is a much weaker inhibitor, being even weaker than the unsubstituted congener glyoxal bis(guanylhydrazone) (GBG, Ki 18 microM). PhGBG inhibited porcine kidney diamine oxidase (DAO) non-competitively, being a more potent inhibitor (Ki 0.12 microM) than GBG (Ki 0.17 microM) or MGBG (Ki 0.33 microM). Thus, PhGBG has an unfavourably high ratio of Ki(AdoMetDC)/Ki(DAO) for potential use for selectively inhibiting polyamine biosynthesis. This does not exclude the possibility that PhGBG or other aromatic congeners might have therapeutic value since the corresponding ratio of the antileukaemic congeners GBG and MGBG is also high as compared to many aliphatic non-antileukaemic analogues. The pKa1 and pKa2 values of PhGBG dication were found to be 6.39 +/- 0.02 and 8.64 +/- 0.02 respectively, their difference being distinctly larger than in the case of GBG or its C-alkylated analogues. This may result from decreased stability of the dication form, caused by the resonance effect or possibly by the inductive effect of the phenyl group. The species distribution of PhGBG (proportion of free base 5.5%, predominant species the monocation) at 37 degrees C resembles that of GBG and MGBG but is clearly different from that of non-antileukaemic C-alkylated analogues. These similarities suggest that PhGBG and its derivatives may be worth antitumour screening. Depending on the conditions used in the crystallization, three different types of crystals of PhGBG sulphate were obtained. Crystallography indicated that, in two of the types, the crystal consisted exclusively of the anti-anti isomer, i.e. the same isomer as has been

  4. Synthesis, characterisation, reactivity and in vitro antiamoebic activity of hydrazone based oxovanadium(IV), oxovanadium(V) and mu-bis(oxo)bis{oxovanadium(V)} complexes.

    Science.gov (United States)

    Maurya, Mannar R; Agarwal, Shalu; Abid, Mohammad; Azam, Amir; Bader, Cerstin; Ebel, Martin; Rehder, Dieter

    2006-02-21

    Binuclear, mu-bis(oxo)bis{oxovanadium(V)} complexes [(VOL)2(mu-O)2](2 and 7)(where HL are the hydrazones Hacpy-nah I or Hacpy-fah II; acpy = 2-acetylpyridine, nah = nicotinic acid hydrazide and fah = 2-furoic acid hydrazide) were prepared by the reaction of [VO(acac)2] and the ligands in methanol followed by aerial oxidation. The paramagnetic intermediate complexes [VO(acac)(acpy-nah)](1) and [VO(acac)(acpy-fah)](6) have also been isolated. Treatment of [VO(acac)(acpy-nah)] and [VO(acac)(acpy-fah)] with aqueous H2O2 yields the oxoperoxovanadium(V) complexes [VO(O2)(acpy-nah)](3) and [VO(O2)(acpy-fah)](8). In the presence of catechol (H2cat) or benzohydroxamic acid (H2bha), 1 and 6 give the mixed chelate complexes [VO(cat)L](HL =I: 4, HL =II: 9) or [VO(bha)L](HL =I: 5, HL =II: 10). Complexes 4, 5, 9 and 10 slowly convert to the corresponding oxo-mu-oxo species 2 and 7 in DMF solution. Ascorbic acid enhances this conversion under aerobic conditions, possibly through reduction of these complexes with concomitant removal of coordinated catecholate or benzohydroxamate. Acidification of 7 with HCl dissolved in methanol afforded a hydroxo(oxo) complex. The crystal and molecular structure of 2.1.5H2O has been determined, and the structure of 7 re-determined, by single crystal X-ray diffraction. Both of these binuclear complexes contain the uncommon asymmetrical {VO(mu-O)}2 diamond core. The in vitro tests of the antiamoebic activity of ligands I and II and their binuclear complexes 2 and 7 against the protozoan parasite Entamoeba histolytica show that the ligands have no amoebicidal activity while their vanadium complexes 2 and 7 display more effective amoebicidal activity than the most commonly used drug metronidazole (IC50 values are 1.68 and 0.45 microM, respectively vs 1.81 microM for metronidazole). Complexes 2 and 7 catalyse the oxidation of styrene and ethyl benzene effectively. Oxidation of styrene, using H2O2 as an oxidant, gives styrene epoxide, 2

  5. The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153

    Directory of Open Access Journals (Sweden)

    Vuyolwethu Siyo

    2017-05-01

    Full Text Available Garlic is a food and medicinal plant that has been used in folk medicine since ancient times for its beneficial health effects, which include protection against cancer. Crushed garlic cloves contain an array of small sulfur-rich compounds such as ajoene. Ajoene is able to interfere with biological processes and is cytotoxic to cancer cells in the low micromolar range. BisPMB is a synthetic ajoene analogue that has been shown in our laboratory to have superior cytotoxicity to ajoene. In the current study we have performed a DNA microarray analysis of bisPMB-treated WHCO1 oesophageal cancer cells to identify pathways and processes that are affected by bisPMB. The most significantly enriched biological pathways as assessed by gene ontology, KEGG and ingenuity pathway analysis were those involving protein processing in the endoplasmic reticulum (ER and the unfolded protein response. In support of these pathways, bisPMB was found to inhibit global protein synthesis and lead to increased levels of ubiquitinated proteins. BisPMB also induced alternate splicing of the transcription factor XBP-1; increased the expression of the ER stress sensor GRP78 and induced expression of the ER stress marker CHOP/GADD153. CHOP expression was found to be central to the cytotoxicity of bisPMB as its silencing with siRNA rendered the cells resistant to bisPMB. The MAPK proteins, JNK and ERK1/2 were activated following bisPMB treatment. However JNK activation was not critical in the cytotoxicity of bisPMB, and ERK1/2 activation was found to play a pro-survival role. Overall the ajoene analogue bisPMB appears to induce cytotoxicity in WHCO1 cells by activating the unfolded protein response through CHOP/GADD153.

  6. Synthesis of a functional C2-symmetrical bidentate diphenylphosphonite DIOP derivative and its conversion into the corresponding pi-acidic bis(pentafluorophenyl) and bis(p-tetrafluoropyridyl) compounds.

    Science.gov (United States)

    Hoge, Berthold; Panne, Patricia

    2006-12-04

    The reaction of a C2-symmetric diiodo compound, 1,4-dideoxy-1,4-diiodo-2,3,-O-isopropyliden-L-threitole, with [K([18]crown-6)]P(CN)2 led to the generation of a corresponding bidentate dicyanophosphorus derivative. The in situ reaction with excess methanol and phenol yielded the corresponding bidentate dimethyl- and diphenylphosphonites, respectively. The isolated liquids were characterized by multinuclear NMR spectroscopy, elemental analysis, and mass spectrometry. The bidentate diphenylphosphonite ligand (a diphenoxyphosphane derivative) represents one of the very few functional bidentate phosphane derivatives: a DIOP [(2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene)]bis(diphenylphosphane) modification, in which the phenyl groups at the phosphorus atoms are replaced by functional phenoxy groups. Treatment of the bidentate diphenylphosphonite derivative with C6F5MgBr and p-C5NF4MgBr allowed the isolation and full characterization of the comparable bidentate bis(pentafluorophenyl) and bis(p-tetrafluoropyridyl)phosphanes. The ligand properties of the novel bidentate ligand systems were evaluated through the synthesis and vibrational investigation of their tetracarbonyl-molybdenum and cyclopentadienyl-iron complexes. The pi acidity of the synthesized ligands increases in the order methoxy-

  7. Manganese–Schiff base complex immobilized silica materials

    Indian Academy of Sciences (India)

    III)]+ and [Mn(salophen)]+: [N,N′-bis(salicylaldehyde)-1,2-phenylenediimino manganese(III)]+ were introduced into/onto the MCM-41 type silica spheres and used for the electrocatalytic reduction of oxygen. Synthesized materials were ...

  8. Bis(μ-2-carboxymethyl-2-hydroxybutanedioatobis[diaquamanganese(II]–1,2-bis(pyridin-4-ylethene–water (1/1/2

    Directory of Open Access Journals (Sweden)

    In Hong Hwang

    2012-12-01

    Full Text Available The asymmetric unit of the title compound, [Mn2(C6H6O72(H2O4]·C12H10N2·2H2O, contains half of the centrosymmetric Mn complex dimer, half of a 1,2-bis(pyridin-4-ylethene molecule, which lies across an inversion center, and one water molecule. Two citrate ligands bridge two MnII ions, and each MnII atom is coordinated by four O atoms from the citrate ligands (one from hydroxy and three from carboxylate groups and two water O atoms, forming a distorted octahedral environment. In the crystal, O—H...O and O—H...N hydrogen bonds link the centrosymmetric dimers and lattice water molecules into a three-dimensional structure which is further stabilized by intermolecular π–π interactions [centroid–centroid distance = 3.959 (2 Å]. Weak C—H...O hydrogen bonding interactions are also observed.

  9. Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl-propanoic acid (bis-HMPA containing peripheral amino acid residues for gene transfection

    Directory of Open Access Journals (Sweden)

    Silvana Alfei

    2017-08-01

    Full Text Available Dendrimers, the emerging man made, highly branched, star-shaped macromolecules with nanometer-scale dimensions are well known for their well defined and high controlled architecture, their versatility and high functionality and are of eminent interest in nanomedical applications such as drug delivery, gene transfection, and imaging. In this paper, versatile protocols for the synthesis of polyester-based, hydrolysable, polycationic dendrimers have been setup. A fourth generation dendrimer equipped with 48 peripheral hydroxyl groups was prepared from 2,2-bis(hydroxymethylpropanoic acid and was used for grafting BOC-amino acids or as “hypercores” on which dendrons functionalized with BOC-amino acids were attached. A library of 15 polycationic homo- and hetero-dendrimers in the form of hydrochloride was obtained. Their structures and composition were confirmed by NMR analysis and by experimental molecular weight computed by volumetric titration. Their buffer capacity and results obtained from cytotoxicity assays and tests of binding with both pDNA and siRNA were very satisfactory.

  10. Junction formation of Cu3BiS3 investigated by Kelvin probe force microscopy and surface photovoltage measurements

    Science.gov (United States)

    Mesa, Fredy; Chamorro, William; Vallejo, William; Baier, Robert; Dittrich, Thomas; Grimm, Alexander; Lux-Steiner, Martha C

    2012-01-01

    Summary Recently, the compound semiconductor Cu3BiS3 has been demonstrated to have a band gap of ~1.4 eV, well suited for photovoltaic energy harvesting. The preparation of polycrystalline thin films was successfully realized and now the junction formation to the n-type window needs to be developed. We present an investigation of the Cu3BiS3 absorber layer and the junction formation with CdS, ZnS and In2S3 buffer layers. Kelvin probe force microscopy shows the granular structure of the buffer layers with small grains of 20–100 nm, and a considerably smaller work-function distribution for In2S3 compared to that of CdS and ZnS. For In2S3 and CdS buffer layers the KPFM experiments indicate negatively charged Cu3BiS3 grain boundaries resulting from the deposition of the buffer layer. Macroscopic measurements of the surface photovoltage at variable excitation wavelength indicate the influence of defect states below the band gap on charge separation and a surface-defect passivation by the In2S3 buffer layer. Our findings indicate that Cu3BiS3 may become an interesting absorber material for thin-film solar cells; however, for photovoltaic application the band bending at the charge-selective contact has to be increased. PMID:22497001

  11. Regioselective Rh-Catalyzed Hydroformylation of 1,1,3-Trisubstituted Allenes Using BisDiazaPhos Ligand.

    Science.gov (United States)

    Eshon, Josephine; Landis, Clark R; Schomaker, Jennifer M

    2017-09-15

    The efficient hydroformylation of 1,1,3-trisubstituted allenes is accomplished with low loadings of a Rh catalyst supported by a BisDiazaPhos (BDP) ligand. The ligand identity is key to achieving high regioselectivity, while the mild reaction conditions minimize competing isomerization and hydrogenation to produce β,γ-unsaturated aldehydes and their derivatives in excellent yields.

  12. A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime.

    Science.gov (United States)

    Legler, Patricia M; Soojhawon, Iswarduth; Millard, Charles B

    2015-09-01

    As part of ongoing efforts to design improved nerve agent antidotes, two X-ray crystal structures of Torpedo californica acetylcholinesterase (TcAChE) bound to the bis-pyridinium oxime, Ortho-7, or its experimental bis-imidazolium analogue, 2BIM-7, were determined. Bis-oximes contain two oxime groups connected by a hydrophobic linker. One oxime group of Ortho-7 binds at the entrance to the active-site gorge near Trp279, and the second binds at the bottom near Trp84 and Phe330. In the Ortho-7-TcAChE complex the oxime at the bottom of the gorge was directed towards the nucleophilic Ser200. In contrast, the oxime group of 2BIM-7 was rotated away from Ser200 and the oxime at the entrance induced a significant conformational change in the peripheral anionic site (PAS) residue Trp279. The conformational change alters the surface of the PAS and positions the imidazolium oxime of 2BIM-7 further from Ser200. The relatively weaker binding and poorer reactivation of VX-inhibited, tabun-inhibited or sarin-inhibited human acetylcholinesterase by 2BIM-7 compared with Ortho-7 may in part be owing to the unproductively bound states caught in crystallo. Overall, the reactivation efficiency of 2BIM-7 was comparable to that of 2-pyridine aldoxime methyl chloride (2-PAM), but unlike 2-PAM the bis-imidazolium oxime lacks a fixed charge, which may affect its membrane permeability.

  13. Reactivity studies of pincer bis-protic N-heterocyclic carbene complexes of platinum and palladium under basic conditions

    Directory of Open Access Journals (Sweden)

    David C. Marelius

    2016-06-01

    Full Text Available Bis-protic N-heterocyclic carbene complexes of platinum and palladium (4 yield dimeric structures 6 when treated with sodium tert-butoxide in CH2Cl2. The use of a more polar solvent (THF and a strong base (LiN(iPr2 gave the lithium chloride adducts monobasic complex 7 or analogous dibasic complex 8.

  14. Zirconium and Titanium Propylene Polymerization Precatalysts Supported by a Fluxional C 2 -Symmetric Bis(anilide)pyridine Ligand

    KAUST Repository

    Tonks, Ian A.

    2012-03-12

    Titanium and zirconium complexes supported by a bis(anilide)pyridine ligand (NNN = pyridine-2,6-bis(N-mesitylanilide)) have been synthesized and crystallographically characterized. C 2-symmetric bis(dimethylamide) complexes were generated from aminolysis of M(NMe 2) 4 with the neutral, diprotonated NNN ligand or by salt metathesis of the dipotassium salt of NNN with M(NMe 2) 2Cl 2. In contrast to the case for previously reported pyridine bis(phenoxide) complexes, the ligand geometry of these complexes appears to be dictated by chelate ring strain rather than metal-ligand π bonding. The crystal structures of the five-coordinate dihalide complexes (NNN)MCl 2 (M = Ti, Zr) display a C 1-symmetric geometry with a stabilizing ipso interaction between the metal and the anilido ligand. Coordination of THF to (NNN)ZrCl 2 generates a six-coordinate C 2-symmetric complex. Facile antipode interconversion of the C 2 complexes, possibly via flat C 2v intermediates, has been investigated by variable-temperature 1H NMR spectroscopy for (NNN)MX 2(THF) n (M = Ti, Zr; X = NMe 2, Cl) and (NNN)Zr(CH 2Ph) 2. These complexes were tested as propylene polymerization precatalysts, with most complexes giving low to moderate activities (10 2-10 4 g/(mol h)) for the formation of stereoirregular polypropylene. © 2012 American Chemical Society.

  15. Bis-ZnIIsalphen complexes bearing pyridyl functionalized ligands for efficient organic light-emitting diodes (OLEDs).

    Science.gov (United States)

    Zhao, Jiang; Dang, Feifan; Liu, Boao; Wu, Yong; Yang, Xiaolong; Zhou, Guijiang; Wu, Zhaoxin; Wong, Wai-Yeung

    2017-05-09

    Inspired by the emissive features of Zn II complexes based on bis-Schiff base ligands, bis-Zn II salphen complexes bearing pyridyl functionalized ligands have been successfully synthesized. Their photophysical features, electrochemical behavior and electroluminescent (EL) properties have been investigated in detail. The functionalized bis-Zn II salphen complexes can exhibit high thermal stability up to 417 °C, and their photoluminescence (PL) spectra show a maximal emission wavelength peak at ca. 565 nm both in solution and PMMA doped films. The PL investigation of the neat films for these functionalized bis-Zn II salphen complexes indicated that the pyridyl functionalized ligands can effectively reduce the degree of molecular aggregation to enhance their emission intensity. Taking advantage of the charge carrier injection/transporting ability of the pyridyl functionalized ligands and their dendritic design, the optimized EL devices fabricated by a simple solution-processing method can achieve a peak luminance (L max ) of 3589 cd m -2 , a maximal external quantum efficiency (η ext ) of 1.46%, a maximal current efficiency (η L ) of 4.1 cd A -1 and a maximal power efficiency (η p ) of 3.8 lm W -1 . These results should afford important instructions for exploiting high performance fluorescent emitters based on dinuclear Zn II complexes.

  16. Gamma spectrometry of EFTTRA T2BIS R280.2. Gamma scan wires 6 through 10

    International Nuclear Information System (INIS)

    Dassel, G.; Buurveld, H.A.; Plakman, J.C.

    1996-11-01

    In the frame work of the EFTTRA programme on recycling of actinides and fission products, five gamma scan wires which were included in the experiment R280.2 T2bis have been examined by gamma scanning. The results of the measurements have been described in this report. (orig.)

  17. Non-p-glycoprotein-mediated multidrug resistance in detransformed rat cells selected for resistance to methylglyoxal bis(guanylhydrazone).

    Science.gov (United States)

    Weber, J M; Sircar, S; Horvath, J; Dion, P

    1989-11-01

    Three independent variants (G2, G4, G5), resistant to methylglyoxal bis(guanylhydrazone), an anticancer drug, have been isolated by single step selection from an adenovirus-transformed rat brain cell line (1). These variants display selective cross-resistance to several natural product drugs of dissimilar structure and action. Multidrug resistance has recently been shown to be caused by overexpression of the membrane-associated p-glycoprotein, most often caused by amplification of the mdr gene. Several types of experiments were conducted to determine whether the observed drug resistance in our cell lines could be due to changes at the mdr locus. The following results were obtained: (a) the mdr locus was not amplified; (b) transcription of the mdr gene and p-glycoprotein synthesis were not increased; (c) multidrug resistance cell lines, which carry an amplified mdr locus, were not cross-resistant to methylglyoxal bis(guanylhydrazone); (d) verapamil did not reverse the resistance of G cells or mdr cells to methylglyoxal bis(guanylhydrazone), nor that of G cells to vincristine; and (e) methylglyoxal bis(guanylhydrazone) resistance was recessive and depended on a block to drug uptake, as opposed to mdr cells which are dominant and express increased drug efflux. The results obtained suggest that the drug resistance in the G2, G4, and G5 cells was atypical and may be due to a mechanism distinct from that mediated by the mdr locus.

  18. Synthesis and Antimicrobial Studies of New Series of Pyrazoline Bearing Bis-Heterocycles via 1,3-Dipolar Cycloaddition Reactions

    Directory of Open Access Journals (Sweden)

    B. Jayashankara

    2008-01-01

    Full Text Available Biologically interesting bis-heterocycles bearing pyrazoline and imidazole moieties have been synthesized. 1H NMR, 13C NMR, IR and elemental analyses characterized the newly synthesized compounds. All the synthesized compounds were evaluated for their antimicrobial activity and were compared with the standard drugs. All the compounds demonstrated potent to weak antimicrobial activity.

  19. Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA

    NARCIS (Netherlands)

    Statham, A.L.; Robinson, M.D.; Song, J.Z.; Coolen, M.W.; Stirzaker, C.; Clark, S. J.

    2012-01-01

    The complex relationship between DNA methylation, chromatin modification, and underlying DNA sequence is often difficult to unravel with existing technologies. Here, we describe a novel technique based on high-throughput sequencing of bisulfite-treated chromatin immunoprecipitated DNA (BisChIP-seq),

  20. 40 CFR 721.9750 - 2-Chloro-4,6-bis(substituted)-1,3,5-triazine, dihydrochloride.

    Science.gov (United States)

    2010-07-01

    ... terrestrial organisms and plants. Notice to users: Release to water restrictions apply. (ii) Disposal... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2-Chloro-4,6-bis(substituted)-1,3,5-triazine, dihydrochloride. 721.9750 Section 721.9750 Protection of Environment ENVIRONMENTAL PROTECTION...