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Sample records for biryushi riyogata seitai

  1. Achievement report for fiscal 1998. Research and development of technologies for creating new bioaffinity molecules using submicron beads (Energy use rationalization related technology practicalization); 1998 nendo biryushi riyogata seitai ketsugo busshitsunado sosei gijutsu no kenkyu kaihatsu seika hokokusho. Energy shiyo gorika kankei gijutsu jitsuyoka kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    In the effort to develop chemical substance/bioreceptor analysis technology using submicron beads, polystyrene core/polyglycidyl methacrilate beads are used in a study started about a detachable spacer using newly developed fixation technology. In the development of bioaffinity chemical substance refining technology, two kinds of sugars and several kinds of aromatic aldehydes serve as building blocks in the construction of a library, and studies are made of analyses using liquid chromatography and mass spectrography. In the development of novel substance creation technology based on information on the analysis of chemical substance/bioreceptor, in an effort at developing technologies for creating novel function provided chemical substances, heterocyclic compounds, alkaloids, and sugar compounds are selected and their syntheses in the liquid phase and solid phase are studied, which is again for the construction of a library. (NEDO)

  2. Exotic Applied Magnetics: Biomagnetism; Kyomiaru jiki oyo: seitai denjikigaku

    Energy Technology Data Exchange (ETDEWEB)

    Iwamoto, Masatami [Kagawa University, Kagawa (Japan). Faculty of Engineering

    1999-09-25

    This paper discusses biomagnetic effects and their possible applications that are unfamiliar to cryogenic and superconducting engineers. Biomagnetism is exotic applied magnetics and a trans-disciplinary research target. There are two types of research methodology, physical and epidemiological. They are quite different. Both methodologies should be harmonized. The author proposes how to work in this transdisciplinary field. Finally, suggestions of guidelines for studing exotic phenomena are presented. (author)

  3. Evolution and ecology of bats; Komori no shinka to seitai

    Energy Technology Data Exchange (ETDEWEB)

    Kuramoto, T.

    1999-12-05

    This paper studies the ecology of bats. The age of the birth of bats is estimated to be from the end of the Mesozoic period to the early part of the Cenozoic period. It is inferred that the fingers were extended in the last stage of the evolution and that a membrane was developed between fingers and turned into wings. Further, improvement of the body was necessary for bats to fly. For example, bats need to have the powerful muscular strength, solid frame for the muscles to adhere to, framework and joints of the wings that surpass air resistance, and the circulatory system and the blood capable of supplying oxygen to the muscles. Different kinds of bats have different patterns of flying, which are each characterized by the shape and the muscle systems of the wings. The flying method has been analyzed in high speed movies. The shoulder joints are essential for the flight while their strength is different by the species. The difference in the flying method governs their ecology (zone of life, number of colony formations). The flocking types are classified into six kinds. The feeds are numerous. They do echo location except non-nocturnal large bats (Pteropodidae). The life span varies depending on the species of bats, ranging widely from 7 to 30 years. (NEDO)

  4. Adsorption behaviors of surface active reagents on barium ferrite magnetic fine particles; Barium ferrite jisei biryushi eno hymen shorizai kyuchaku

    Energy Technology Data Exchange (ETDEWEB)

    Kudo, M.; Otani, T.; Masuko, T. [Yamagata University, Yamagata (Japan). Faculty of Engineering

    1998-06-10

    The adsorption mode of lecithin (dioleoylphosphatidylcholine) or [3-(methacryloyloxy)propyl] trimethoxysilane (MPS) onto barium ferrite magnetic particles has been investigated by measurements of changes in solution concentration of the surfactant. Both adsortion isotherms of the surface active reagents on barium ferrite particles indicated to be of the Langmuir type. The occupied areas per one molecule on the surface of barium ferrite particles were estimated to be about 70 angstrom{sup 2}/molecule for lecithin and 22 angstrom{sup 2}/molecule for MPS at their saturated adsorption. In X-ray photoelectron spectroscopy (XPS) measurements for the adsorbed lecithin layer, the peak position in the binding energy distribution for the P (2p) photoelectron was observed to shift into slightly higher values with increasing amount of adsorbed lecithin. This implies that dipole-dipole interactions among the lecithin molecules become stronger because of increased high molecular packing in the adsorption layers. However, the peak position for the Si (2p) photoelectron remains almost unchanged due to slight interaction among the adsorbing functional groups onto the particles. 16 refs., 16 figs., 3 tabs.

  5. Medical mechatronics which imitates living organisms. Seitai ni manabu iyo mechatronics

    Energy Technology Data Exchange (ETDEWEB)

    Ikuta, K. (Kyushu Inst. of Technology, Fukuoka (Japan))

    1991-11-01

    Medical equipments which aim at replacement of biological functions require some different mechatronic elements from industrial ones and such medical equipments are being developed with the object of imitating the functions of living organisms. Research and development of actuators and transmission devices with new principles modelling the functions of living organisms are presented. Servoactuators of small size and large output for their weights are constructedby the use of shape memory alloy. Prototypes of active endoscope and active catheter have been manufactured. A prototype of a cybernetic actuator have been manufactured by imitating flexible motion characteristics of biological muscle systems by the use of piezoelectric devices. A rotor-type cybernetic actuator consists of a pair of layered piezoelectric devices and a rotor with a small gap inbetween. A linear tvpe cybernetic actuator consists of piezoelectric devices for restricting the actuator and impact driving. A transmission mechanism of a new principle whose features are safety, no noise and nodusts is designed by the use of non-contact magnetic gears. 10 refs., 6 figs.

  6. Nano organic (block copolymer)-inorganic (gold) composite particle; Burokku kyojugo porima to kin tono yuki {center_dot} muki fukugo nano biryushi

    Energy Technology Data Exchange (ETDEWEB)

    Yamachita, H. [National Institute of Materials and Chemical Research, Tsukuba (Japan)

    1999-12-01

    Synthesis of nano-scale inorganic particles and development of the application to electronics, photonics and catalytic reactions are recently paid attention. Nguyen, Mirkin et al. recently reported a simple method for synthesizing a nano organic-inorganic composite particle by polymerizing a monomer on the surface of a gold particle. The polymerization employs ring-opening metathesis polymerization of norbornene ring, and the point is using a Ru catalyst that makes living polymerization possible. In addition, Weiss, Grubbs et al. used the same method to grow a homopolymer of the similar norbornene monomer on the gold surface, and directly observed the existence of a polymer chain with a length of several hundred A or greater on the gold surface with an interatomic force microscope, a scanning tunnel microscope and scanning electron microscope. The reactions used in these cases is considered to be easily adapted to other monomers having a norbornene ring. This method is regarded as an effective method for forming a copolymer or a homopolymer having a uniform length on metal particles. (NEDO)

  7. Study on the advanced orientation control technology of biopolymers; Seitai kobunshi zairyo no kodo haiko hairetsu seigyo gijutsu no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Creation of new functional organic materials for the medical application has been investigated under the microgravity. Facilities of the Japan Microgravity Center were used for this study. For the high-speed synthesis of uniform polymer particles under the microgravity condition for ten seconds, appropriately good results were obtained in the oxidation polymerization of pyrroles. For the synthesis of organic conductive thin films by the electrolytic polymerization, the resistance of electrolyte became larger in the microgravity field. It was required to set conditions so as to enhance the effects of microgravity environment. For the orientation control and thin film formation of proteins, the bacteriorhodopsin was examined. It was found that the microgravity improved the quality of electrocoatings. When the surface tension and viscosity of coating liquid were appropriately controlled under the microgravity, thin films were able to be prepared by utilizing a change from 1g to {mu}g. When the high viscosity fluid is placed in the artificial two-dimensional space composing of two parallel plates, and the low viscosity fluid, such as air, is injected into the above, the interface grows in the finger shaped pattern, namely, viscous fingering. The influence of gravity on this phenomenon was also investigated. 11 refs., 45 figs., 5 tabs.

  8. Study about the effect of microgravity on biofunctions; Seitai kino eno bisho juryoku no eikyo ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    A study is made for the elucidation of the effect of microgravity on biofunctions. The protoplast of shiitake is exposed to microgravity and then cultured, and a significant difference occurs. The rate of colony formation by cell fusion in the test sector is found to be two times higher than that in the control sector. When swimming ciliates which are unicellular are suddenly exposed to microgravity, their swimming speeds changed differently according to the direction of swimming. When a mouse subjected to acupuncture for three days is exposed to microgravity, its water metabolism and excretory function are enhanced. A mouse treated with Chinese medicine reacts in the similar way. The change due to microgravity in the amount of acetylcholine in the hypothalamus is found characteristically time dependent. Mice infected with lethal herpes viruses just after exposure to microgravity die at a rate in proportion to the number of exposures and to the amount of viruses given. The migration speed of chemical stripes in case of a gel-base BZ (Belousov-Zhabotinsky) reaction under microgravity is equal to that on the ground. The trigger wave migration speed in case of a water solution-base BZ reaction under microgravity is reduced to approximately 80% of the speed on the ground. 12 refs., 31 figs., 3 tabs.

  9. Ultra-low light level imaging and its application to biosciences. Goku bijakuko imaging to sono seitai keisoku eno oyo

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, T. (Hamamatsu Photonics K.K., Shizuoka (Japan))

    1992-12-05

    This paper describes an ultra-high sensitivity TV camera (photon counting camera) that can detect photons one by one and image them under ultra-low level light, and its application. Photographing under ultra-low level light has become possible by using a two-dimensional photon counting method. In observing movements of sea urchin roes before and after fertilization, fluidity of the membranes was quantified two-dimensionally and chronologically. In the example of the number of fluorescent molecules sealed in red blood cell ghosts, the number was imaged up to 10 molecules per ghost. Its most characteristic application would be to utilize its capability of imaging performance under as low light as incident photons would not almost superpose with each other in terms of space and time. The number of biological photons after about one week of sowing soybean seeds was several hundred photons per cm[sup 2]/S in a portion receiving abundance of light on a test sample. Other applications may include imaging Ca ions discharged during fertilization of the roes, chronological observation on process of active oxygen release from white blood cells in defective nutrition, and visualization of gene emergence utilizing luciferin-luciferase light emission. 8 refs., 9 figs.

  10. Preparation of spherical fine particulate pigments within water-in-oil emulsions and their properties. (II). ; Formation mechanism and characteristic of spherical fine particulate pigment of tartrazine. W/O emulsion wo mochiita kyujo biryushi ganryo no chosei to seishitsu(dai 2 ho). ; Kiiro 4 go kyujo biryushi ganryo no seisei kiko to tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Imai, T.; Iwano, K.; Hotta, H.; Takano, S.; Tsutsumi, H. (Kao Corporation, Tokyo (Japan))

    1991-12-20

    The previous report explained that an excellent spherical particulate pigment with a grain size of 0.5 mm or less can be obtained by preparing multinuclear aluminum lakes from acidic dyes and multinuclear aluminum salt using water droplets in a W/O emulsion as reaction fields. This paper describes preparing pigments varying the charging concentrations of the pigments in a W/O emulsion and the droplet particle size to discuss the mechanism of forming the pigments. As a result, it was found that the particle sizes in the produced pigments have a clear correlation with the charging concentrations of the pigments and the droplet particle sizes in the W/O emulsion. A pigment produced in the W/O emulsion forms only in its own droplets, and reflects its particle sizes. Films dispersed with pigments having different particle sizes were prepared to discuss their tinting abilities, whereas it was clarified that the smaller the particle size, the higher the tinting ability and the higher saturation in colored paint films. 6 refs., 9 figs., 3 tabs.

  11. Fiscal 1997 survey report. Basic survey on trends of waste use type production facilities and waste fuel production facilities; 1997 nendo chosa hokokusho. Haikibutsu riyogata seizo shisetsu oyobi haikibutsu nenryo seizo shisetsu doko kiso chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    This survey was made to obtain the basic data for future spread and promotion of No.6 type (waste use type production facilities) and No.7 type (waste fuel production facilities) which were added to the objects having been subsidized since fiscal 1997 under `the environmental harmony type energy community project.` In the former, the kiln in the cement industry and the blast furnace in the steel industry can be extremely large places to receive waste plastic since the facilities are distributed in every area and the treatment capacity is large. However, the effective collection, transportation and sorting of large quantity of waste plastic, especially the problem of removal of vinyl chloride, is a big bottleneck. As to the use of waste plastic using gasification technology, there are no actual results on the commercial basis. That is, however, appropriate for treatment of the waste difficult in treatment, and can be expected of the usage in the chemical industry. In the latter, in the facilities using industrial waste raw materials as fuel, solidification and liquefaction are both operated on a commercial basis. In relation to the solidification and use as fuel of general waste, the treatment of combustion ash is preventing the expansion of use of waste in the industrial field because of a large quantity of chlorine included in the products. 92 refs., 54 figs., 35 tabs.

  12. FY1995 new technology of artificial organ materials which can induce host biocompatibility; 1995 nendo jinko zokiyo seitai kino fukatsukagata sozai no kaihatsu gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    The aim of this project is to produce a highly biocompatible materials for next generation's artificial organs using the following methods: 1, Micromodification of polymer materials. 2, Biocompatible treatment for biological materials. 3, Application of bioabsorbable materials. 4, Bioactive substance immobilization. and 5, Use of autologous tissue as artificial organ materials. As a synthetic polymer material, microporous polyurethane was used for a small diameter vascular prosthesis. The graft with this technology was successfully implanted in rat abdomical aortic position. The graft of 1.5 mm in internal diameter and 10 cm in length showed excellent patency with nice endothelialisation. As a biological material, microfibers of collagen was used for a sealing substance of vascular prothesis. The microfibers absorbed a large amount of water, which could prevent blood leakage from the graft wall. The graft showed non-thrombogenic property and excellent host cell affinity, resulted in rapid neointima formation. As to autologous tissue, bone marrow was used, since marrow cells can differentiate into any mesenchimal cells with synthesis of growth factors. Marrow cell transplanted vascular prothesis showed rapid capillary ingrowth. These results indicated that the newly designed materials had suitable properties for materials of next generation's artificial organs. (NEDO)

  13. FY1995 new technology of artificial organ materials which can induce host biocompatibility; 1995 nendo jinko zokiyo seitai kino fukatsukagata sozai no kaihatsu gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The aim of this project is to produce a highly biocompatible materials for next generation's artificial organs using the following methods: 1, Micromodification of polymer materials. 2, Biocompatible treatment for biological materials. 3, Application of bioabsorbable materials. 4, Bioactive substance immobilization. and 5, Use of autologous tissue as artificial organ materials. As a synthetic polymer material, microporous polyurethane was used for a small diameter vascular prosthesis. The graft with this technology was successfully implanted in rat abdomical aortic position. The graft of 1.5 mm in internal diameter and 10cm in length showed excellent patency with nice endothelialisation. As a biological material, microfibers of collagen was used for a sealing substance of vascular prothesis. The microfibers absorbed a large amount of water, which could prevent blood leakage from the graft wall. The graft showed non-thrombogenic property and excellent host cell affinity, resulted in rapid neointima formation. As to autologous tissue, bone marrow was used, since marrow cells can differentiate into any mesenchimal cells with synthesis of growth factors. Marrow cell transplanted vascular prothesis showed rapid capillary ingrowth. These results indicated that the newly designed materials had suitable properties for materials of next generation's artificial organs. (NEDO)

  14. Study on the effect of micro-gravity on bio-functions; Seitai kino eno bisho juryoku no eikyo ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The effect of micro-gravity on bio-functions and vital reaction was studied using the facility of Underground Gravity-free Experiment Center Co. On the effect on osteoblast shape and gene expression, although fluorochrome reacting with Ca was well taken into cells, no significant difference in Ca content in cells was observed before/after falling. Expression of genes related to cell propagation was controlled under micro-gravity. Protoplast fusion of Lentinus was unaffected by micro-gravity. The mRNA fragments of gravity sensitive mutant of rice plant were affected by micro-gravity. Paramecium was set swimming in solutions with different specific gravities. The reaction behavior of Paramecium was affected by the difference in specific gravity between cell bodies and solutions. The water content metabolism functions of a mouse with needle stimulus, in particular excretory, were slightly promoted by micro- gravity. The cortisol level in blood of a falling mouse group rose showing strong stress. As the preliminary study on the geotaxis of insects, motion of bagworm was observed. 12 refs., 38 figs., 4 tabs.

  15. Robots targeted at living beings. Part 2. Challenging artificial initiative antenna; Seitai wo mezasu robotto. 2. Jinko nodo shokkaku ni charenji

    Energy Technology Data Exchange (ETDEWEB)

    Kaneko, M. [Hiroshima Univ., Hiroshima (Japan)

    1995-10-20

    When the antenna of the insect is observed through a microscope, the first thing that attracts attention may be the flexibility and the initiative actions of the antenna. The flexibility has a cushioning effect against the charging force occurring when the antenna touched an object, while the initiative actions have the effect of enlarging the sensing area. In order to confirm, with real insects, the extent of the sensing ability that the sensors concentrated on the root section of the antenna are able to display, the author made an experiment by cutting the antenna of the cockroach, bonding the cut antenna to the remaining short antenna on the root section with instantaneous adhesives, reconstructing the antenna artificially and observing the action of the cockroach. In this paper, after an introduction of the research examples of the antenna sensors of robots developed for inspecting and picking out obstacles, the action principle of the artificial initiative antenna and the development of the two-dimensional plan model and its action limitations are described. Finally, the structure of the three-dimensional artificial initiative antenna of a three-dimensional space model is introduced. 9 refs., 8 figs.

  16. Robots targeted at living beings. Part 5. Future of artificial intelligence and robotics; Seitai wo mezasu robotto. 5. Jinko chino to robotikusu no shorai

    Energy Technology Data Exchange (ETDEWEB)

    Kakazu, Y. [Hokkaido Univ., Sapporo (Japan). Graduate School

    1995-10-20

    In the artificial intelligence and robotics, robot design principle Sub-Sumption Architecture (SSA) being non-Descartes approach proposed by R.Brooks of MIT is a new strong trend in the robot research and development. In this paper, the recent trend of the artificial intelligence being conscious of applying into robot is described. Specially, the new trend of the artificial intelligence and robotics is introduced from the viewpoint of non-Descartes approach. A recognizable sensor and a memory of results of sensing, collection of action types, action evaluation method, action strategy and action miss processing are necessary in the non-Descartes approach under the conditions of no definition. The SSA robot obtains informations about cockroach`s action, uses environment information obtained from a simple vision sensor and a touch sensor, may get over obstacles, for example, and moves to destination on which peoples come and go. 7 refs., 1 fig.

  17. Study of the influence of microgravity on the biological cells and molecular level; Seitai saibo bunshi level ni okeru bisho juryoku no eikyo ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    The shape of osteoblast, gene appearance, gene of rice blast, cellular fusion of plants, gravity acceptance mechanism of unicellular organisms, and physiological and immunity functions of mice were investigated under the microgravity condition. The influence of gravity on the vital reaction and the influence of microgravity on the crystallization of vital substances were also investigated. For the observation of osteoblast, the fluorescence dye reacted with Ca was well taken in the cells. The microgravity affected the stability of rice blast, but hardly affected the protoplast culture of mushroom. The reaction of ciliate against the gravity related to the specific gravity difference between cells and outer liquid. The level of adrenaline in blood of mice increased during the drop. The moving speed of trigger waves of chemical parallel slit formed at the BZ reaction under the microgravity became 60% to 80% of that on the ground. In the case of crystallization at the deposition agent concentration of 1% to 4%, the turbidity showing the degree of crystallization changed complicatedly. Nine processes of crystal growth were recognized. 21 refs., 55 figs., 1 tab.

  18. Influences of species of metals and supports on the hydrogenation activity of carbon-supported metal sulfides catalysts; Tanso biryushi tanji shokubai no suisoka kassei ni taisuru kassei kinzoku oyobi tantaishu no eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Sakanishi, K.; Hasuo, H.; Taniguchi, H.; Nagamatsu, T.; Mochida, I. [Kyushu University, Fukuoka (Japan). Institute of Advanced Material Study

    1996-10-28

    In order to design catalysts suitable for primary liquefaction stage and secondary upgrading stage respectively in the multi-stage liquefaction process, various carbon-supported catalysts were prepared. Catalytic activities of them were investigated for the hydrogenation of 1-methylnaphthalene, to discuss the influences of metals and carbon species on the catalytic activity. Various water soluble and oil soluble Mo and Ni salts were used for NiMo supported catalysts. Among various carbon supports, Ketjen Black (KB) was effective for preparing the catalyst showing the most excellent hydrogenation activity. The KB and Black Pearl 2000 (BP2000) showing high hydrogenation activity were fine particles having high specific surface area more than 1000 m{sup 2}/g and primary particle diameter around 30 nm. This was inferred to contribute to the high dispersion support of active metals. Since such fine particles of carbon exhibited hydrophobic surface, they were suitable for preparing catalysts from the methanol-soluble metals. Although Ni and Mo added iron-based catalysts provided lower aromatic hydrogenation activity, they exhibited liquefaction activity competing with the NiMo/KB catalyst. 3 refs., 1 fig., 3 tabs.

  19. Research on the preparation of highly functional ceramics aiming at fusing together with living cells. Pt. 2; Seitai saibo tono yugoka wo mezashita kokinosei ceramics sosei gijutsu ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Nishizawa, K.; Suzuki, T.; Nagae, H.; Kawamoto, Y.; Yokogawa, Y.; Nagata, F.; Tariyama, M.; Kameyama, T. [National Industrial Research Institute of Nagoya, Nagoya (Japan)

    2000-03-06

    The surface characteristics of surface-modified biocompatible ceramics made of {beta}-tricalcium phosphate (TCP) were found to change actively in tissue culture medium. Concentration changes of calcium and phosphate ions dissolved in distilled water or in culture medium showed that the solubility of the TCP ceramics was considerably high and depended on the pH value of the soaking medium. The most stable ceramics in the culture condition appeared to have the suitable surface for adhesion of L 929 cells. So, the solubility of the TCP ceramics as the cell carrier was considered to be the dominant factor in decreasing the adhesion of cells on TCP ceramics. Furthermore, it was found that the solubility and zeta potential of the surface-modified TCP ceramics, and cell adhesion and serum protein adsorption on the surface were varied with modification time. (author)

  20. FY 2000 report on the results of the research and development project for utilization of information of high-molecular-weight structures in a living body. Survey on the technological trends of utilizing the reactions with metals in a living body; 2000 nendo seitai kobunshi kozo joho riyo gijutsu kaihatsu chosa hokokusho. 'Seitai kinzoku hanno riyo gijutsu' ni kansuru gijutsu doko chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Described herein are the FY 2000 results of the survey on the technological trends of utilizing the reactions with metals in a living body, noting the bio-processes effectively coping with the environmental problems. The effects of heavy metals on microorganisms have been investigated on the molecular biology level, but are not fully elucidated. Recently, the microorganisms capable of converting inorganic metal ions in water into the insoluble compounds have been known, leading to possibility of bioremediation to solve pollution by heavy metals, which have detrimental effects on human health. Heavy metals must be recovered, because they are not extinct by decomposition. The plant aided purification has been attracting attention to cope with heavy metals accumulated in soil. Application of bacteria-aided leaching, which is adopted as one ore smelting process, to the technologies for utilizing metals in a living body has been expected, because diversified activities of inanimate matters in extreme environments have been known. Recently, bio-machining of metals aided by Thiobacillus ferrooxidans, one species of independent nutrient bacteria capable of eating metals, has been developed to a potentially viable stage. (NEDO)

  1. Research on the preparation of highly functional ceramics aiming at fusing together with living cells. Pt. 1. Application for biomaterial; Seitai saibo tono yugo ka wo mezashitaa kokinosei ceramics sosei gijutsu ni kansuru kenkyu. 1. Seibutesugakuteki shuho wo mochiita zairyo kaihatsu wo mezashit

    Energy Technology Data Exchange (ETDEWEB)

    Inagaki, H.; Maeda, S.; Kato, K.; Saito, T. [National Industrial Research Institute of Nagoya, Nagoya (Japan)

    2000-03-06

    We isolated the gene of Bone Morphogenic Proteins-1 (BMP-1) by RT-PCR (Reverse Transcriptase Polymerase Chain Reaction), and produced BMP-1 protein for the industrial application. We clarified theroles of BMP-2 and BMP-4, which are other members of BMPs, in cardiovascular formation at an early stage of embryo. In addition, we isolated a novel gene from bone mRNA and termed it rDLG-6. From the sequence comparisons by the BLASTX program, we found that rDLG 6 is a member of MAGUK (Membrane Associated Guanylate Kinase) family. (author)

  2. Report on survey in fiscal 2000 on the survey and research on technology to integrate artificial bone system with living organism, taking individual difference into account; 2000 nendo kotaisa wo koryoshita jinkokotsu system no seitai tekigoka gijutsu ni kansuru chosa kenkyu hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Survey and research have been performed on artificial bones as to the bone growth and bone absorption mechanism, nature demanded in artificial bones, and ideal concept of artificial bones. As a result of the survey, the following matters were made clear: Ti alloy draws high attention as the artificial bone material; and up-to-date research is being made to promote fusion of the Ti alloy bone with natural bones by putting apatite covering on the Ti alloy bone by means of chemical treatment, wherein porous layers are produced on the surface that do not form inclination from a dense bone to a sponging bone, or from high density to low density, but produce the reverse inclination, as in the cross section structure of natural bones. Reports have been given from the dentistry, oral surgery, plastic surgery, and orthopedic surgery on the followings: a fact that magnesium affects greatly the stimulation of osteoblasts; a case where absorption of the mandibular bone has been created clinically due to Ti-made mini-plate; and a case where even Ti has been eluted into soft tissues. Artificial bones made of magnesium structure is being studied as one of the solutions thereof. (NEDO)

  3. Fiscal 1998 achievement report on regional consortium research and development project. Regional consortium of venture business fostering type--Creation of key industries (Development of technologies for manufacturing and utilizing various biological regulatory substances using Hokkaido-produced biomasses as materials); 1998 nendo Dosan biomass wo genryo to shita kakushu seitai chosetsu kino busshitsu no seisan riyo gijutsu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The efforts aim to meet consumers' needs for products that will prevent lifestyle diseases or the like. For this purpose, substances answering the purpose are extracted from Hokkaido-produced agricultural and aquatic biomasses, and prepared for testing. Researches are conducted on how they behave in the enzyme, cell, and biological systems, and active substances are isolated and identified. In relation to the aquatic biomass, a technology is established of extracting and separating DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), taurine, etc., which are multivalent unsaturated fatty acids effective in preventing lifestyle diseases, from the unused parts of the squid. In relation to the agricultural biomass, antimicrobial active substances are extracted and separated from small fruit plants such as the chicory. Long-keeping foods are tentatively produced by the addition of dried powder of the chicory root tuber. In the elucidation of various biological regulatory substances contained in the Hokkaido-produced biomasses, they are tested for their abilities to resist microbes and active oxygen. Furthermore, verification tests are conducted by administering the substances to the senescence-accelerated mouse (SAM). (NEDO)

  4. Fiscal 1998 regional consortium R and D project (Regional consortium field). Report on R and D of production technology of hybrid-type biocompatible hard tissue replacing materials (1st fiscal year); 1998 nendo chiiki konsoshiamu kenkyu kaihatsu jigyo. Chiiki konsoshiamu bun'ya (hybrid gata seitai yugo kinosei kososhiki daitai sozai seizo gijutsu no kenkyu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    This project aims at development of high-strength high- biocompatible {beta}-type Ti alloy with lower modulli of elasticity composed of non-toxic elements, phosphate calcium ceramics for improving the biocompatibility and coating technology, and establishment of production technology of hybrid-type biocompatible hard tissue replacing materials. In fiscal 1998, the project promoted the following: Design of high-biocompatible {beta}-type Ti alloy materials, development of thermomechanical treatment for improving dynamic characteristics of such alloy, survey on practical melting and casting technologies and dental precision casting process, evaluation of the biocompatibility of the alloy by cytotoxicity, selection of tools for precision machining and surface finishing, control of contents, orientation and precipitation of biocompatible crystals such as {beta}- Ca(PO{sub 3}){sub 2} fibers for further improvement of the biocompatibility. This paper also outlines the survey results on the market needs, market size and market share for the feasibility of these materials. (NEDO)

  5. Fiscal 1997 report on the results of the international standardization R and D. System to make comprehensive evaluation of potential health effects of next generation image media; 1997 nendo seika hokokusho kokusai hyojun soseigata kenkyu kaihatsu. Jisedai media seitai eikyo sogo hyoka system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The paper proposed the international standardization for the use of next generation image media by evaluating health effects of the use of next generation image media such as head mounted display and 3D monitor. A method to comprehensively evaluate health effects was studied with the design friendly to humans and standardization on safety as final targets. Themes were divided into the autonomous nervous system and the measuring system. The development was carried out of a method to evaluate the autonomous nervous function by the dynamic state of blood circulation and pupillary reflex as well as the development of portable sphygmomanometer and pupillometer. Using these developmental instruments and conventional instruments, measurement was made of blood pressure, cardiac output, respiration, pupil size, eyeball movement and focus accommodation. A possibility was suggested of obtaining the uniform elucidation also in case analytical changes of individual parameters cannot be extracted or consistency cannot be seen in the course of changes. The paper determined basic standards for the experimental use stereoscopic image, made measuring use 3D images, and collected realtime data by the overall simultaneous measuring system constructed. 109 refs., 166 figs., 18 tabs.

  6. Randomized Comparison of the Therapeutic Effect of Acupuncture, Massage, and Tachibana-Style-Method on Stiff Shoulders by Measuring Muscle Firmness, VAS, Pulse, and Blood Pressure

    Directory of Open Access Journals (Sweden)

    Kazuhiro Tachibana

    2012-01-01

    Full Text Available To compare the therapeutic efficacy of acupuncture, massage, and Tachibana-Ryojutsu (one of Japanese traditional body balance therapy techniques (SEITAI, on stiff shoulders, the subjects’ muscle firmness, blood pressure, pulse, VAS, and body temperature were measured before and after the treatment. Forty-seven volunteer subjects gave written informed consent to participate in this study. The subjects were randomly divided into three groups to receive acupuncture, massage, or Tachibana-Ryojutsu. Each therapy lasted for 90 seconds. The acupuncture treatment was applied by a retaining-needle at GB-21, massage was conducted softly on the shoulders, and Tachibana-Ryojutsu treated only the muscles and joints from the legs to buttocks without touching the shoulders or backs. The study indicated that the muscle firmness and VAS of the Tachibana-Ryojutsu group decreased significantly in comparison with the acupuncture and massage groups after treatment.