Fiscal 1998 survey report. Medical equipment (Development of fine sampling/analysis system for blood / Development of high-precision 3-D image diagnosis system / Development of low-invasion operation support system / Total development of artificial internal organ technologies); 1998 nendo chosa hokokusho. Iryo kiki (ketsuekinado biryo saishu, biryo bunseki system kaihatsu/koseido sanjigen eizo shindan system kaihatsu/teishinshu shujutsu shien system kaihatsu/jinko zoki gijutsu sogo kaihatsu)
For efficient medical care supply systems, the R and D of advanced medical care technology and equipment largely contribute to productivity improvement for medical care services. Among them, a progress of medical care technology is becoming important for preparation of efficient and fair supply systems. MITI thus established 'Medical care and welfare equipment development project' in 1994, and has promoted the strategic long-term R and D project of medical care and welfare equipment as joint R and D project of NEDO and private enterprises. In fiscal 1998, on the development of the fine sampling/analysis system for blood, the high- precision 3-D image diagnosis system, the low-invasion operation support system, and the artificial internal organ technologies since fiscal 1996, this project clarified essential technical issues based on the future view, selected some themes to be newly developed in the future, and surveyed and evaluated the details of their R and D concretely. (NEDO)
Development of stereoselective analytical methods of chiral drugs and biological substances and application of hepatic local drug disposition; Yakubutsu oyobi biryo seiri kassei busshitsu no rittai sentakuteki bunri bunsekiho no kaihatsu to kanzo kyokusho dotai kaiseki eno oyo
Nakagawa, T. [Kyoto University, Kyoto (Japan). Faculty of Engineering
With an objective to elucidate the structure recognizing ability possessed by living organisms, discussions were given on methods to analyze the bonds between optically active drugs and polymers, and methods to analyze drug disposition fluid-dynamically. Studies have been advanced on the following themes, and the results were obtained therefrom: development of an on-line system to quantify non-protein bonding type concentrations in drugs utilizing the high-performance fraction analysis (HPFA, using a restricted movement type HPLC column) that had been already developed, establishment of a method to analyze hepatic local drug disposition by using the MULTI (drug disposition analyzing) program, and studies on stereoselectivity by using NMR generated by interactions of local anesthetics and lipids. The following findings were obtained: using the above on-line system, a discussion was given on protein bonds between BOF-4272 (xanthine oxidase inhibitor) and serum albumins, and the discussion was found effective in analyzing the stereoselectivity in drugs with strong protein bond; and with the above analytic method, optical behavior of ketoprofen (KP) in rat liver perfusion was discussed, wherein the transfer of KP into liver tissues was estimated to have been caused by involvement of active transportation rather than physical diffusion. 7 refs., 6 figs., 4 tabs.
Batch process. Batch super-fractionation as analysis technique (Development of a pretreatment apparatus for the analysis of microcomponents in the water); Bunseki gijutsu toshiteno bacchi seimitsu joryu - suichu niokeru biryo seibun no bunseki yozen shori sochi no kaihatsu -
To analyze high boiling point organic contaminants in the water, first, the contaminants are extracted by using organic solvents, and condensed to such concentrations that they are in the ranges suited to the sensitivities of the analyzers used. Using a newly developed pretreatment apparatus for the analysis of microcontaminants in the water, samples to be analyzed are prepared by automatic condensation of the extracted samples by batch distillation. All of the series operations, i.e. cleaning the apparatus, introducing samples, condensing the samples, taking out the samples and cleaning the apparatus are automated. In the automation, a computer system for an ASTM distilling apparatus, a drop counter for measuring the amount of evaporated liquid and a float type liquid level control apparatus for controlling the measurement of the liquid level are utilized. In order to detect the contaminants remaining in the apparatus after cleaned, a gas chromatograph mass spectrometer is used as an ultramicroanalysis technique. The sequence of the automatic operation was programmed by using a personal computer, and the operation data were logged, whereby data necessary for quantitative analysis, such as the calculation of material balance were stored. 2 figs., 1 tab.
The last lecture of Dr. Okamura, a Prof. at the engineering department of Tokyo University, was held on March 27, 1999. He was a well-known baseball pitcher who won 17 victories at Tokyo 6-College baseball league. In his development of high-performance concrete (later renamed to-self compacting concrete), he thought that we should not demand fine technique for concrete application, but instead we should cover the technique by the advantages of a material. His hardship existed in expressing the properties of cement in numeric values and the establishment of numerical analysis technique starting from empirical equation. He stated that he was able to succeed in the development of an ideal concrete with high-strength, high-durability, self-compacting concrete with the suggestions from many colleagues. He will become Vice President of Kochi Univ. and Chairman of Civil Eng. Society. (translated by NEDO)
Report on New Sunshine Program-supported undertakings for fiscal 1995. Development of hot water power plant and deep-seated geothermal resources sampling/exploiting technologies; 1995 nendo New Sunshine keikaku hojo jigyo seika hokokusho. Nessui riyo hatsuden plant nado kaihatsu (shinbu chinetsu shigen saishu gijutsu no kaihatsu, shinbu chinetsu shigen seisan gijutsu no kaihatsu)
Reported are the results of researches conducted in fiscal 1995. For the formulation of a general development design, data are collected about domestic high-temperature thermal wells through questionnaires and literature probing, and are scrutinized. As for the development of logging technology, a memory type PT (Pressure, Temperature) logger is experimentally constructed, and is found to properly operate in an environment of up to 350degC in a production well. An experimentally manufactured S-probe proves to be capable of heat insulation and sealing. In the field of PT monitoring, a high-temperature optical fiber is experimentally fabricated for study, capable of measuring temperatures up to 400degC. As for the development of high-temperature tracer monitoring technology, basic experiments are conducted about the thermal characteristics of aromatic acids, and preparatory experiments about gas phase tracers. In the study of scale monitoring technology, deep-seated fluids are collected and analyzed. In the field of production control, technical problems are discussed and information is gathered centering on methods for scale prevention and removal. 31 refs., 90 figs., 40 tabs.
Report on New Sunshine Program-supported undertakings for fiscal 1997. Development of hot water power plant and deep-seated geothermal resources sampling/exploiting technologies; 1997 nendo New Sunshine keikaku hojo jigyo seika hokokusho. Nessui riyo hatsuden plant nado kaihatsu, shinbu chinetsu shigen saishu gijutsu no kaihatsu, shinbu chinetsu shigen seisan gijutsu no kaihatsu
Reported are the results of researches conducted in fiscal 1997. In the field of PTSD (Pressure, Temperature, Spinner flowmeter, fluid Density) well logging, the high-temperature performance of a memory type PT (Pressure, Temperature) well logger is confirmed in a demonstration test. As for the S-probe, modification is effected for the reduction of the outside diameter from 70mm to 56mm, and tests are conducted in real wells. As for the D-probe, a laboratory test is conducted and then the probe behaves as predicted. In the field of PCT (Pressure, Chemical, Temperature) monitoring, the sampler is subjected to an on-site test in Italy, when water is successfully sampled out of the well. In the field of scale monitoring technique, deep-seated fluid is collected and examined, and the scale deposition rate in the deep-seated fluid is determine. For the study of production control technology with respect to scale prevention and removal, an Mg-Si scale synthesis test is conducted in the temperature range of 100-300degC, and it is found that the solubility of scale decreases with a rise in temperature. 19 refs., 93 figs., 24 tabs.
Fiscal 1995 report on the results of the subsidy operation under the Sunshine Project on the development of a geothermal water use power plant, etc. Development of the deep geothermal resource collecting technology (development of the deep geothermal resource drilling technology); 1995 nendo New Sunshine keikaku hojo jigyo seika hokokusho. Nessui riyo hatsuden plant nado kaihatsu (shinbu chinetsu shigen saishu gijutsu no kaihatsu / shinbu chinetsu shigen kussaku gijutsu no kaihatsu)
The paper reported the results of the fiscal 1995 R and D on the development of deep geothermal resource collecting/drilling technology. In the design of a total development, the trend of technical development was examined of bits, cement and DHM overseas. Further, the simulational prediction was conducted in deep geothermal drilling. As to the development of element technology of hard high temperature strata drilling, the R and D of seal mechanism, bearing mechanism and cutter mechanism were carried out aiming at developing heat resistant/durable bits, and a bit was trially manufactured which was integrated with element parts selected by each element technology. Concerning the development of high temperature drilling mud, studies were made of the development of drilling mud materials, a mud system, etc. Relating to the development of high temperature cement slurry, the development was conducted of high temperature cement, dewatering adjusting agents, etc. As to the development of high accuracy much inclination drilling technology, in the development of high temperature use downhole motor, tests on heat resistance/durability were carried out in the mud of 12 kinds of high heat resistant stator materials. 175 figs., 137 tabs.
Fiscal 1996 report on the results of the subsidy operation under the Sunshine Project on the development of a geothermal water use power plant, etc. Development of the deep geothermal resource collecting technology (development of the deep geothermal resource drilling technology); 1996 nendo New Sunshine keikaku hojo jigyo seika hokokusho. Nessui riyo hatsuden plant nado kaihatsu (shinbu chinetsu shigen saishu gijutsu no kaihatsu / shinbu chinetsu shigen kussaku gijutsu no kaihatsu)
The paper reported the results of the fiscal 1996 R and D on the development of deep geothermal resource collecting/drilling technology. In the design of a total development, the planned adjustment of actual well tests was conducted on bits and drilling mud at the time of drilling the exploration well of the Kakkonda area. As to the trend of overseas technology, examined was the developmental trend of high temperature type downhole motor products. In the development of hard high temperature strata drilling element technology, a drilling test was carried out on trially manufactured 300degC heat resistant/durable bits. In the development of high temperature drilling mud, drilling was done in the mud of thermally stable quality in the actual well experiment using the 300degC mud system. In the development of high temperature use cement and high temperature use cement slurry, a possibility was obtained of composing a slurry which has the targeted dewatering amount, compressive strength, and water permeability. In the development of high temperature downhole motor, data on characteristics of heat resistant stator materials were arranged in a relationship among the abrasion amount, thermal expansion amount and elastic recovery amount, and the database was obtained. 166 figs., 148 tabs.
FY 2000 report on the results of the regional consortium R and D project - Regional consortium energy field. Final year report. R and D on the bio-fuel production by high functional bio-reactor; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo - chiiki consortium energy bun'ya. Kokino bio reactor ni yoru bio nenryo seisan ni kansuru kenkyu kaihatsu (saishu nendo) seika hokokusho
A system was developed for producing automobile fuel from the recycled paper and waste cooking oil using high functional intelligent yeast. Element technology is the functional yeast creation technology and the online intelligent control technology of the process into which the fixed bio-reactor was inserted. Studies were made on the following: 1) creation of high activity lipase production/ethanol production yeasts; 2) bio-fuel production by intelligent bio-reactor; 3) process optimization control technology by fuzzy control; 4) stabilization of bio-fuel production yeast; 5) comprehensive investigational study. In FY 2000, the results were obtained as written below: development of the stable lipase coming from rhizopus japonicus, fixed bacterium using rhizopus oryzae fungus body which can be used more than ten times, direct ethanol fermentation from starch by developing the multi-copy glucoamylase manifestation yeast, operation of a 20L capacity bench plant, etc. (NEDO)
Tsuchiya, N.; Asanuma, H.; Sakaguchi, K.; Okamoto, A.; Hirano, N.; Watanabe, N.; Kizaki, A.
experiments, our research goals are 1)Analysis and understanding of geothermal structure and geofluids in ductile condition of the Japanese Island arc, 2)Fundamental technologies of drilling under ductile region for geothermal reservoir, 3) Development of geothermal reservoir simulator of two phase and multiphase flow including supercritical state through rock fracture, 4) Lab scale support for ICDP-JBBP, 5) Application of new EGS technologies to conventional geothermal fields as recovery from the 2011 Great East Japan Earthquake and energy crisis in Japan. [Publications Relevant to the Research] Tsuchiya, N. and Hirano, N. (2007), ISLAND ARC, 16, 6-15. Okamoto, A., Saishu, H., Hirano, N. & Tsuchiya, N. (2010) Geochimica et Cosmochimica Acta, 74, 3692-3706. Majer, E.L., Baria, R., Stark, M., Oates, S., Bonner, J. Smith, B. & Asanuma H., (2007) Geothermics, 36, 185-222. Watanabe, N., Hirano, N. Tsuchiya, N. (2009) Journal of Geophysical Research B: Solid Earth, 114(4), B04208.