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Sample records for birth defects registry

  1. Birth defects registries in the genomics era: challenges and opportunities for developing countries

    Directory of Open Access Journals (Sweden)

    Meow-Keong eThong

    2014-06-01

    Full Text Available Birth defects or congenital anomalies are one of the major causes of disability in developed and developing countries. Data on birth defects from population-based studies originating from developing countries are lacking. Increasingly there is a shift to genetic testing and genomics study of birth defects. However the translation from bench findings to bedside medicine has been muted. There is a need to address this imbalance where congenital anomalies remained the top aetiology for neonatal mortality in developing countries. To build capacity in low resource countries, there is a need for accurate collection and ascertainment of birth defects in developing countries. The systematic collection and analysis of data on major birth defects using birth defects registries (BDR are an integral part of all clinical genetic services. Healthcare planners in developing countries must be aware of the advantages and limitations of BDRs. Despite the advent of the genomics era, BDRs are essential to the planning and developing care and prevention services at local and national levels, particularly in low resource or developing countries.

  2. Congenital malformations in Ecuadorian children: urgent need to create a National Registry of Birth Defects

    Directory of Open Access Journals (Sweden)

    Fabricio González-Andrade

    2010-04-01

    Full Text Available Fabricio González-Andrade1, Ramiro López-Pulles21Department of Medicine, Metropolitan Hospital, Quito, Ecuador; 2Science and Technology Process of the Ministry of Public Health, Biomedical Center of the Central University and Regional Autonomic University of the Audes, Quito, Ecuador Universidad Central del Ecuador, Quito, EcuadorAim: This study sets out (a to estimate the prevalence of admissions by birth defects, using the official database of hospitals of Ecuador; and (b to set the basis for a new National Register of Birth Defects in Ecuador that works as a program for the clinical and epidemiological investigation of risk factors in the etiology of congenital anomalies in Ecuadorian hospitals, using a case-control methodological approach. This is the first report in their class.Methods: The data used in this study are derived from the National Register of Hospital Admission/Discharges of the Instituto Nacional de Estadísticas y Censos; data of the Ministry of Public Health were also used. Ecuador does not have an official Medical Birth Registry or a Congenital Malformations Registry.Results: A total of 51,375 discharges by congenital malformations were registered in a 7-year period. Of these, 16,679 admissions were of children aged less than 1 year of age, with a birth prevalence rate (BPR of 72.33/10,000 births. 77% of the congenital defects registered comprise the 50 most common birth defects observed in this age group. Cleft lip was the most prevalent birth defect in children less than 1 year of age and the second most common defect in children 1 to 5 years of age. Unilateral cleft lip shows a BPR of 4.57/10,000 births; cardiac birth defects as a group have a BPR of 4.2; hydrocephalus a BPR of 3.77; and Down’s syndrome a BPR of 3.70. Undescended testicle was the most prevalent birth defect in children between 1 to 5 years. 9384 children under 1 year of age were male (55.9% and 7053 were female (42.1%. BPR in males was 40.45 and in

  3. Methodological Approaches to Evaluate Teratogenic Risk Using Birth Defect Registries: Advantages and Disadvantages

    Science.gov (United States)

    Poletta, Fernando A.; López Camelo, Jorge S.; Gili, Juan A.; Leoncini, Emmanuele; Castilla, Eduardo E.; Mastroiacovo, Pierpaolo

    2012-01-01

    Background Different approaches have been used in case-control studies to estimate maternal exposure to medications and the risk of birth defects. However, the performance of these approaches and how they affect the odds ratio (OR) estimates have not been evaluated using birth-defect surveillance programmes. The aim of this study was to evaluate the scope and limitations of three case-control approaches to assess the teratogenic risk of birth defects in mothers exposed to antiepileptic medications, insulin, or acetaminophen. Methodology/Principal Findings We studied 110,814 non-malformed newborns and 58,514 live newborns with birth defects registered by the Latin American Collaborative Study of Congenital Anomalies (ECLAMC) between 1967 and 2008. Four controls were randomly selected for each case in the same hospital and period, and three different control groups were used: non-malformed newborns (HEALTHY), malformed newborns (SICK), and a subgroup of SICK, only-exposed cases (OECA). Associations were evaluated using OR and Pearson's chi-square (P<0.01). There were no concordance correlations between the HEALTHY and OECA designs, and the average OR differences ranged from 3.0 to 11.5 for the three evaluated medicines. The overestimations observed for HEALTHY design were increased as higher OR values were given, with a high and statistically significant correlation between the difference and the mean. On the contrary, the concordance correlations obtained between the SICK and OECA designs were quite good, with no significant differences in the average risks. Conclusions The HEALTHY design estimates the true population OR, but shows a high rate of false-positive results presumably caused by differential misclassification bias. This bias decreases with the increase of the proportion of exposed controls. SICK and OECA odds ratios cannot be considered a direct estimate of the true population OR except under certain conditions. However, the SICK and OECA designs could

  4. Screening Tests for Birth Defects

    Science.gov (United States)

    ... Management Education & Events Advocacy For Patients About ACOG Screening Tests for Birth Defects Home For Patients Search ... for Birth Defects FAQ165, April 2014 PDF Format Screening Tests for Birth Defects Pregnancy What is a ...

  5. Birth Defects (For Parents)

    Science.gov (United States)

    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which ... there is a problem with a baby's body chemistry, it is called a metabolic birth defect. Metabolic ...

  6. The spatial evaluation of neighborhood clusters of birth defects

    Energy Technology Data Exchange (ETDEWEB)

    Frisch, J.D.

    1990-04-16

    Spatial statistics have recently been applied in epidemiology to evaluate clusters of cancer and birth defects. Their use requires a comparison population, drawn from the population at risk for disease, that may not always be readily available. In this dissertation the plausibility of using data on all birth defects, available from birth defects registries, as a surrogate for the spatial distribution of all live births in the analysis of clusters is assessed. Three spatial statistics that have been applied in epidemiologic investigations of clusters, nearest neighbor distance, average interpoint distance, and average distance to a fixed point, were evaluated by computer simulation for their properties in a unit square, and in a zip code region. Comparison of spatial distributions of live births and birth defects was performed by drawing samples of live births and birth defects from Santa Clara County, determining the street address at birth, geocoding this address and evaluating the resultant maps using various statistical techniques. The proposed method was then demonstrated on a previously confirmed cluster of oral cleft cases. All live births for the neighborhood were geocoded, as were all birth defects. Evaluation of this cluster using the nearest neighbor and average interpoint distance statistics was performed using randomization techniques with both the live births population and the birth defect population as comparison groups. 113 refs., 36 figs., 16 tabs.

  7. Intrauterine Infections and Birth Defects

    Institute of Scientific and Technical Information of China (English)

    XIAO-YING ZHENG; XIN-MING SONG; LI-HUA PANG; YING JI; HONG-MEI SUN; LEI ZHANG; JU-FEN LIU; YAN-LING GUO; YAN ZHANG; TING ZHANG; YI-FEI WANG; CHEN XU; GONG CHEN; RUOLEI XIN; JIA-PENG CHEN; XU-MEI HU; QING YANG

    2004-01-01

    Intrauterine infection is an important cause of some birth defects worldwide. The most common pathogens include rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. General information about these pathogens in epidemiology, consequence of birth defects, and the possible mechanisms in the progress of birth defects, and the interventions to prevent or treat these pathogens' infections are described. The infections caused by rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. are common, yet they are proved to be fatal during the pregnant period, especially during the first trimester. These infections may cause sterility, abortion, stillbirth, low birth weight, and affect multiple organs that may induce loss of hearing and vision, even fetal deformity and the long-term effects. These pathogens' infections may influence the microenvironment of placenta, including levels of enzymes and cytokines, and affect chondriosome that may induce the progress of birth defect. Early diagnosis of infections during pregnancy should be strengthened. There are still many things to be settled, such as the molecular mechanisms of birth defects, the effective vaccines to certain pathogens. Birth defect researches in terms of etiology and the development of applicable and sensitive pathogen detection technology and methods are imperative.

  8. Birth Defects Data and Statistics

    Science.gov (United States)

    ... About Us Information For... Media Policy Makers Data & Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ... and critical. Read below for the latest national statistics on the occurrence of birth defects in the ...

  9. Defying birth defects through diet?

    OpenAIRE

    Crider, Krista S.; Lynn B. Bailey

    2011-01-01

    The risk of certain birth defects can be modified by maternal diet. A high-fat maternal mouse diet has recently been reported to substantially increase the penetrance of birth defects known to be associated with a deficiency of transcription factor Cited2 as well as induce cleft palate. These effects were associated with a more than twofold reduction in embryonic expression of Pitx2c. This investigation suggests the need to further explore this provocative gene-diet interaction in human studies.

  10. Alarming Rise In Birth Defects

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A rapid rise in birth defects has prompted China to look for causes and solutionsEvery 60 seconds two children are born in China with a handicap.It’s an alarming fact,but one that young adults across the country who hope to have children face every day. At a conference on the prevention of birth defects in Chengdu of Sichuan Province in September,Vice Minister of the National Population and Family Planning Commission Jiang Fan revealed this inconvenient truth, supported by shocking statistics.

  11. Guidance for Preventing Birth Defects

    Science.gov (United States)

    ... healthy during pregnancy, and giving your baby a healthy start in life will help you to have peace of mind. Before pregnancy » During pregnancy » To learn about CDC’s work to help prevent birth defects, visit our Research and Tracking page. Related Links Disability and Health ...

  12. Paternal occupation and birth defects: findings from the National Birth Defects Prevention Study.

    NARCIS (Netherlands)

    Desrosiers, T.A.; Herring, A.H.; Shapira, S.K.; Hooiveld, M.; Luben, T.J.; Herdt-Losavio, M.L.; Lin, S.; Olshan, A.F.

    2012-01-01

    Objectives: Several epidemiological studies have suggested that certain paternal occupations may be associated with an increased prevalence of birth defects in offspring. Using data from the National Birth Defects Prevention Study, the authors investigated the association between paternal occupation

  13. CDC Reports Six Cases of Birth Defects Caused by Zika

    Science.gov (United States)

    ... Reports Six Cases of Birth Defects Caused by Zika Three babies born with defects, while three pregnancies ... 2016 (HealthDay News) -- In the first reporting of Zika-related birth defects in the United States, federal ...

  14. Descriptive epidemiology of selected birth defects, areas of Lombardy, Italy, 1999

    Directory of Open Access Journals (Sweden)

    Frassoldi Emanuela

    2007-05-01

    Full Text Available Abstract Background Birth defects are a leading cause of neonatal and infant mortality in Italy, however little is known of the etiology of most defects. Improvements in diagnosis have revealed increasing numbers of clinically insignificant defects, while improvements in treatment have increased the survival of those with more serious and complex defects. For etiological studies, prevention, and management, it is important to have population-based monitoring which provides reliable data on the prevalence at birth of such defects. Methods We recently initiated population-based birth defect monitoring in the Provinces of Mantova, Sondrio and Varese of the Region of Lombardy, northern Italy, and report data for the first year of operation (1999. The registry uses all-electronic source files (hospital discharge files, death certificates, regional health files, and pathology reports and a proven case-generation methodology, which is described. The data were checked manually by consulting clinical records in hospitals. Completeness was checked against birth certificates by capture-recapture. Data on cases were coded according to the four-digit malformation codes of the International Classification of Diseases, Ninth Revision (ICD-9. We present data only on selected defects. Results We found 246 selected birth defects in 12,008 live births in 1999, 148 among boys and 98 among girls. Congenital heart defects (particularly septal defects were the most common (90.8/10,000, followed by defects of the genitourinary tract (34.1/10, 000 (particularly hypospadias in boys, digestive system (23.3/10,000 and central nervous system (14.9/10,000, orofacial clefts (10.8/10,000 and Down syndrome (8.3/10,000. Completeness was satisfactory: analysis of birth certificates resulted in the addition of two birth defect cases to the registry. Conclusion This is the first population-based analysis on selected major birth defects in the Region. The high birth prevalences for

  15. Sex ratios among infants with birth defects, National Birth Defects Prevention Study, 1997-2009.

    Science.gov (United States)

    Michalski, Adrian M; Richardson, Sandra D; Browne, Marilyn L; Carmichael, Suzan L; Canfield, Mark A; VanZutphen, Alissa R; Anderka, Marlene T; Marshall, Elizabeth G; Druschel, Charlotte M

    2015-05-01

    A small number of population-based studies have examined sex differences among infants with birth defects. This study presents estimates of sex ratio for both isolated cases and those with multiple congenital anomalies, as well as by race/ethnicity. Male-female sex ratios and their 95% confidence intervals were calculated for 25,952 clinically reviewed case infants included in the National Birth Defects Prevention Study (1997-2009), a large population-based case-control study of birth defects. The highest elevations in sex ratios (i.e., male preponderance) among isolated non-cardiac defects were for craniosynostosis (2.12), cleft lip with cleft palate (2.01), and cleft lip without cleft palate (1.78); the lowest sex ratios (female preponderance) were for choanal atresia (0.45), cloacal exstrophy (0.46), and holoprosencephaly (0.64). Among isolated cardiac defects, the highest sex ratios were for aortic stenosis (2.88), coarctation of the aorta (2.51), and d-transposition of the great arteries (2.34); the lowest were multiple ventricular septal defects (0.52), truncus arteriosus (0.63), and heterotaxia with congenital heart defect (0.64). Differences were observed by race/ethnicity for some but not for most types of birth defects. The sex differences we observed for specific defects, between those with isolated versus multiple defects, as well as by race/ethnicity, demonstrate patterns that may suggest etiology and improve classification. PMID:25711982

  16. Defining smallness for gestational age in the early years of the Danish Medical Birth Registry

    DEFF Research Database (Denmark)

    á Rogvi, Rasmus; Mathiasen, Rene; Greisen, Gorm

    2011-01-01

    Being born small for gestational age (SGA) is associated with decreased insulin sensitivity and increased blood pressure in childhood, but the association with clinical disease in early adulthood is less certain. The Danish Medical Birth Registry has registered all births in Denmark since 1973...

  17. Spatiotemporal Property Analysis of Birth Defects in Wuxi, China

    Institute of Scientific and Technical Information of China (English)

    JI-LEI WU; GONG CHEN; XIN-MING SONG; CHENG-FU LI; LEI ZHANG; LAN LIU; XIAO-YING ZHENG

    2008-01-01

    Objective To describe the temporal trends and spatial patterns of birth defects occurring in Wuxi, a developed region of China. Methods Wavelet analysis was used to decompose the temporal trends of birth defect prevalence based on the birth defect rates over the past 16 years. Birth defect cases with detailed personal and family information were geo-coded and the relative risk in each village was calculated. General G statistic was used to test the spatial property with different scales. Results Wavelet analysis showed an increasing temporal trend of birth defects in this region. Clustering analysis revealed that changes continued in the spatial patterns with different scales. Conclusion Wuxi is confronted with severe challenges to reduce birth defect prevalence. The risk factors are stable and show no change with spatial scale but an increasing temporal trend. Interventions should be focused on villages with a higher prevalence of birth defects.

  18. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1994-05-01

    The US DOE funded this grant to the Medical University of South Carolina for a cancer and birth defects registry for an initial three year period which was completed as of April 29, 1994. While this Technical Progress Report is prepared principally to document the activities of year 03, it also summarizes the accomplishments of the first two years in order to put into perspective the energy and progress of the program over the entire three year funding cycle.

  19. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    International Nuclear Information System (INIS)

    The US DOE funded this grant to the Medical University of South Carolina for a cancer and birth defects registry for an initial three year period which was completed as of April 29, 1994. While this Technical Progress Report is prepared principally to document the activities of year 03, it also summarizes the accomplishments of the first two years in order to put into perspective the energy and progress of the program over the entire three year funding cycle

  20. Beating Birth Defects (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2013-01-17

    Each year in the U.S., one in 33 babies is affected by a major birth defect. Women can greatly improve their chances of giving birth to a healthy baby by avoiding some of the risk factors for birth defects before and during pregnancy. In this podcast, Dr. Stuart Shapira discusses ways to improve the chances of giving birth to a healthy baby.  Created: 1/17/2013 by MMWR.   Date Released: 1/17/2013.

  1. The influence of the post-Chernobyl fallout on birth defects and abortion rates in Austria.

    Science.gov (United States)

    Haeusler, M C; Berghold, A; Schoell, W; Hofer, P; Schaffer, M

    1992-10-01

    Researchers analyzed data on 66,743 births which occurred between 1985-1989 in the Styria region in southern Austria to determine whether radioactive fallout from the meltdown of the nuclear reaction at Chernobyl in the Ukraine, USSR in may 1986 affected the birth defect and abortion rates in this area of Austria. There were 1695 birth defect cases. Of the birth defects which occurred during embryogenesis, most occurred 14-49 days postconception (group 2; n=630). The researchers did not note a short-term effect of the fallout in group 2 or the other groups (relative risk= 0.75, 0.73 for group 1, and 0.93 for group 2). Baseline birth defect rates (per 1000 births) for groups 1, 2, and 3 were 2.5, 8.5, and 1,8 respectively. The only sizable increase occurred in group 2 at years 2 and 3 (10.6 and 10.3, respectively). More reported minor congenital defect cases accounted for this increase due to the newly established data base in the Department of Pediatric Cardiology at the University of Graz. Thus the increase was an artifact and not a true increase. Abortion rates varied from 10% to 14% and did not increase significantly after Chernobyl. Counseling frequency at abortion clinics fluctuated greatly (117-205) both before and after Chernobyl and the changes were not significant. These results indicated that the low dosage of radiation did not have a detectable biologic effect in terms of birth defects and abortions. The researchers addressed the difficulties with measuring teratologic potential of low dose radiation. They also highlighted the need for accurate categorizing of birth defects, adequate baseline data, and very reliable registries. Future research on possible environmental disasters which affect Austria can use these data as baseline data. PMID:1415387

  2. Birth defects, causal attributions, and ethnicity in the national birth defects prevention study.

    Science.gov (United States)

    Case, Amy P; Royle, Marjorie; Scheuerle, Angela E; Carmichael, Suzan L; Moffitt, Karen; Ramadhani, Tunu

    2014-10-01

    In order to translate research findings into effective prevention strategies, it is important to understand people's beliefs about the causes of poor health outcomes. However, with the exception of knowledge and beliefs about folic acid supplementation, little is known regarding women's causal attributions women regarding birth defects. We employed Attribution Theory constructs to analyze open-text interview responses from 2,672 control mothers in the National Birth Defects Prevention Study who gave birth in 1997-2005. Common themes included use of alcohol, tobacco, illicit drugs, and medications during pregnancy. Stress and emotional upset were also suggested as possible causes of birth defects. Genetic- and heredity-related responses were more likely to be mentioned by Asian/Pacific Islander women compared to non-Hispanic Whites. Hispanic women were less likely to suggest several specific possible teratogens, such as paint, pesticides, or other chemicals, but were more likely to suggest events occurring during childbirth. Differences also emerged among ethnic groups for theoretical constructs, although most responses were categorized as controllable, changeable over time, and with an internal locus of causality. PMID:24682893

  3. Cancer and birth defects surveillance system for communities around the Savannah River Site: Phase 2 -- Birth defects. Technical progress report, year 01

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1995-10-01

    The Savannah River Region Health Information System Birth Defects Registry (SRRHIS-BDR) began on September 30, 1994. As with the SRRHIS Cancer Registry, surveillance of the 12 Georgia counties was subcontracted to Emory University School of Public Health. Collaborative efforts between the Medical University of South Carolina (MUSC) and Emory University staffs have been characterized by warm relationships and commitment to developing a state of the art registry. As a result of early planning efforts, the authors were able to actually activate the data collection. As of the end of September 1995, partial data from the 1994 birth cohort and up-to-date data for the 1995 birth cohort had been collected on the South Carolina side. The Georgia Staff started later and have not yet caught up to the 1994 level. South Carolina was able to start earlier because they were fortunate to quickly recruit an abstractor. Also, by the end of the first year, an innovative automated data entry system for laptop computers was developed by the computer staff to facilitate and improve data collection.

  4. Cancer and birth defects surveillance system for communities around the Savannah River Site: Phase 2 -- Birth defects. Technical progress report, year 01

    International Nuclear Information System (INIS)

    The Savannah River Region Health Information System Birth Defects Registry (SRRHIS-BDR) began on September 30, 1994. As with the SRRHIS Cancer Registry, surveillance of the 12 Georgia counties was subcontracted to Emory University School of Public Health. Collaborative efforts between the Medical University of South Carolina (MUSC) and Emory University staffs have been characterized by warm relationships and commitment to developing a state of the art registry. As a result of early planning efforts, the authors were able to actually activate the data collection. As of the end of September 1995, partial data from the 1994 birth cohort and up-to-date data for the 1995 birth cohort had been collected on the South Carolina side. The Georgia Staff started later and have not yet caught up to the 1994 level. South Carolina was able to start earlier because they were fortunate to quickly recruit an abstractor. Also, by the end of the first year, an innovative automated data entry system for laptop computers was developed by the computer staff to facilitate and improve data collection

  5. Defining smallness for gestational age in the early years of the Danish Medical Birth Registry

    DEFF Research Database (Denmark)

    á Rogvi, Rasmus; Mathiasen, Rene; Greisen, Gorm

    2011-01-01

    due to variable data quality, data is most often used only from 1981 onwards, and birth registers in other countries may have similar problems for the early years. We wanted to examine whether the data can be used for identification of children born SGA and used in future research.......Being born small for gestational age (SGA) is associated with decreased insulin sensitivity and increased blood pressure in childhood, but the association with clinical disease in early adulthood is less certain. The Danish Medical Birth Registry has registered all births in Denmark since 1973, but...

  6. A Prescription for the Prevention of Birth Defects.

    Science.gov (United States)

    Slavkin, Harold C.

    1984-01-01

    Factors influencing birth defects include maternal age (teenagers and women over 32 are at risk), genetics, drug use, diet habits, and environmental hazards. The physical, social, and economic costs of birth defects are extreme. Prevention must involve efforts to change some of these factors. (Author/CS)

  7. Birth Defects in India: Magnitude, Public Health Impact and Prevention

    Directory of Open Access Journals (Sweden)

    Anita Kar

    2014-07-01

    Full Text Available Birth defects refer to a group of diverse congenital conditions, which are responsible for stillbirths, neonatal deaths, chronic medical conditions and disability. Due to their low prevalence and high mortality, birth defects are not considered to be a significant health problem in India. Various data however identify that India may harbour a significant burden of birth defects, and that these conditions may be responsible for a considerable proportion of neonatal deaths in India. Although it is widely assumed that survival of patients with birth defects is low, data suggests that in 2002, there were nearly six million Indians living with impairments arising at birth. These data urge the need for implementation of a national birth defects programme in India, with a strong component of prevention. The need for significant research investments to understand the epidemiology and public health impact of birth defects in India is identified. Translation research, transcending the disciplines of medicine, public health and genetics is required to develop a low cost birth defects service as a component of the existing maternal and child health programme.

  8. Neural tube defects in Costa Rica, 1987-2012: origins and development of birth defect surveillance and folic acid fortification.

    Science.gov (United States)

    Barboza-Argüello, María de la Paz; Umaña-Solís, Lila M; Azofeifa, Alejandro; Valencia, Diana; Flores, Alina L; Rodríguez-Aguilar, Sara; Alfaro-Calvo, Thelma; Mulinare, Joseph

    2015-03-01

    Our aim was to provide a descriptive overview of how the birth defects surveillance and folic acid fortification programs were implemented in Costa Rica-through the establishment of the Registry Center for Congenital Anomalies (Centro de Registro de Enfermedades Congénitas-CREC), and fortification legislation mandates. We estimated the overall prevalence of neural tube defects (i.e., spina bifida, anencephaly and encephalocele) before and after fortification captured by CREC. Prevalence was calculated by dividing the total number of infants born with neural tube defects by the total number of live births in the country (1987-2012).A total of 1,170 newborns with neural tube defects were identified from 1987 to 2012 (1992-1995 data excluded); 628 were identified during the baseline pre-fortification period (1987-1991; 1996-1998); 191 during the fortification period (1999-2002); and 351 during the post-fortification time period (2003-2012). The overall prevalence of neural tube defects decreased from 9.8 per 10,000 live-births (95 % CI 9.1-10.5) for the pre-fortification period to 4.8 per 10,000 live births (95 % CI 4.3-5.3) for the post-fortification period. Results indicate a statistically significant (P Folic acid fortification via several basic food sources has shown to be a successful public health intervention for Costa Rica. Costa Rica's experience can serve as an example for other countries seeking to develop and strengthen both their birth defects surveillance and fortification programs.

  9. The Survey of Birth Defects Rate Based on Birth Registration System

    OpenAIRE

    Min Yu; Zhiguang Ping; Shuiping Zhang; Yuying He; Rui Dong; Xiong Guo

    2015-01-01

    Background: To investigate the surveillance trend of birth defects, incidence, distribution, occurrence regularity, and their relevant factors in Xi′an City in the last 10 years for proposing control measures. Methods: The birth defects monitoring data of infants during perinatal period (28 weeks of gestation to 7 days after birth) were collected from obstetrics departments of all hospitals during 2003-2012. Microsoft Excel 2003 was used for data input, and Statistical Package for the Soc...

  10. The Survey of Birth Defects Rate Based on Birth Registration System

    OpenAIRE

    Yu, Min; Ping, Zhiguang; Zhang, Shuiping; He, Yuying; Dong, Rui; Guo, Xiong

    2015-01-01

    Background: To investigate the surveillance trend of birth defects, incidence, distribution, occurrence regularity, and their relevant factors in Xi’an City in the last 10 years for proposing control measures. Methods: The birth defects monitoring data of infants during perinatal period (28 weeks of gestation to 7 days after birth) were collected from obstetrics departments of all hospitals during 2003–2012. Microsoft Excel 2003 was used for data input, and Statistical Package for the Social ...

  11. Scientists to tackle birth defects, disabilities in Beijing

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Beijing will host the Second International Conference on Birth Defects and Disabilities in the Developing World from September 11 to 14, with estimated 1,200 participants from dozens of countries, an official with the organizing committee said here Thursday.

  12. Preventive program of birth defects: incidence of anencephaly in Maracaibo, Venezuela. 1993-1996 period

    International Nuclear Information System (INIS)

    Incidence of anencephaly in the State of Zulia, and specifically in the Eastern Coast of Lake Maracaibo, an oil exploitation area, has been declared high since the beginning of the 80's, coincident with the generalized use of ultrasound as a diagnostic tool for fetal evaluation. Through the Birth Defects Preventive Program, established at the Hospital Chiquinquira in Maracaibo, we have developed a fourfold strategy for the study of birth defects: i) analysis of more than 32,332 ultrasound evaluations within the Ultrasound Service, between 1993 and 1996, ii) a case-control malformation registry beginning in 1995, iii) a study of malformed stillbirths at the Pathology Service, observed after 4232 deliveries within this hospital, and iv) a registry of over 638 mothers with high risk pregnancy for fetal defects detected at the prenatal clinic and carried out at the Perinatal Medical Genetics Service. As a reference population we study 345 medical histories obtained from the Medical Genetics and Prenatal Diagnostic Service at Hospital Coromoto, and oil companies related medical facility. This approach has led us to conclude that the incidence of anencephaly in the State of Zulia is 0.75/1000, significantly similar to that expected for most populations

  13. The Survey of Birth Defects Rate Based on Birth Registration System

    Directory of Open Access Journals (Sweden)

    Min Yu

    2015-01-01

    Conclusions: A downward trend of birth defects was observed in Xi′an City from 2003 to 2012. NTDs significantly decreased after large-scale supplemental folic acid intervention, while the incidence rate of CHD significantly increased.

  14. Public health approach to birth defects: the Argentine experience.

    Science.gov (United States)

    Bidondo, María Paz; Groisman, Boris; Barbero, Pablo; Liascovich, Rosa

    2015-04-01

    Birth defects are a global problem, but their impact is particularly severe in low and middle income countries, where the conditions for prevention, treatment, and rehabilitation are more critical. The epidemiological transition in the infant mortality causes, and the concern of the community and the mass media about the teratogenic risk of environmental pollutants, has made health authorities aware of the importance of birth defects in Argentina. The objective of this paper is to outline those actions specifically taken in Argentina aimed at the prevention of birth defects at a national level. Firstly, we focus on birth defects in Argentina on a general basis, and then we present different laws and actions taken in terms of surveillance and public health programs, primary, secondary, and tertiary prevention. Finally, we present the Teratology Information Service "Fetal Health Line", and the genetic services organization and health professionals training by the National Center of Medical Genetics and the National Program of Genetics Network. In conclusion, in the country, several programs focus on different approaches to the problem, and the challenge is to coordinate the teamwork between them. Finally, we list tips to address birth defects from the public health perspective. PMID:25564015

  15. Evaluating alcohol related birth defects in the past

    DEFF Research Database (Denmark)

    Shuler, Kristrina A.; Schroeder, Hannes

    2013-01-01

    Alcohol Related Birth Defects (ARBD) are yet undocumented among past communities, although alcohol is the leading cause of non-heritable birth defects in the US today. We evaluate potential ARBD at Newton Plantation, Barbados (ca. 1660-1820), where earlier studies suggest frequent, community......-wide consumption of lead-tainted rum by enslaved Africans. Skeletons excavated in 1997-1998 (n= 45) were examined for congenital anomalies, using clinical/experimental descriptions to differentially diagnose possible ARBD. Enamel lead data served as a proxy for developmental exposure to tainted rum in a subsample...

  16. Laterality Defects in the National Birth Defects Prevention Study (1998–2007): Birth Prevalence and Descriptive Epidemiology

    Science.gov (United States)

    Lin, Angela E.; Krikov, Sergey; Riehle-Colarusso, Tiffany; Frías, Jaime L.; Belmont, John; Anderka, Marlene; Geva, Tal; Getz, Kelly D.; Botto, Lorenzo D.

    2015-01-01

    Little is known epidemiologically about laterality defects. Using data from the National Birth Defects Prevention Study (NBDPS), a large multi-site case-control study of birth defects, we analyzed prevalence and selected characteristics in children born with laterality defects born from 1998 to 2007. We identified 517 nonsyndromic cases (378 heterotaxy, 73.1%; 139 situs inversus totalis [SIT], 26.9%) resulting in an estimated birth prevalence of 1.1 per 10,000 live births (95% confidence interval 1.0–1.2). Prevalence did not differ significantly across sites, over time, or by inclusion of pregnancy termination. Laterality defects were more common among preterm cases compared to term cases, and in children born to mothers who were non-white or younger than 20 years compared to white mothers or those age 25–29 years. The distribution of associated cardiac and extracardiac defects, excluding the expected heterotaxy anomalies, varied by type of laterality defect. Cases with heterotaxy were significantly more likely than those with SIT to have double outlet right ventricle, atrioventricular canal defects, pulmonary stenosis, non-tetralogy of Fallot pulmonary atresia with ventricular septal defect, totally and partially anomalous pulmonary venous return; also more likely to have orofacial clefts, esophageal atresia, bowel atresias, and omphalocele, though not reaching statistical significance. Relatively more common among cases with SIT were Dandy-Walker malformation, anotia/microtia, and limb deficiency. The similarity in the demographic characteristics of heterotaxy and SIT supports the hypothesis that they are part of a continuum of abnormal left-right axis patterning. These findings on laterality defects may help guide clinical care, future research, and prevention strategies. PMID:25099286

  17. The primary prevention of birth defects: Multivitamins or folic acid?

    OpenAIRE

    Andrew E. Czeizel

    2004-01-01

    Periconceptional use of folic acid alone or in multivitamin supplements is effective for the primary prevention of neural-tube defects. The Hungarian randomized and two-cohort controlled trials showed that periconceptional multivitamin supplementation can reduce the occurrence of some other structural birth defects, i.e. congenital abnormalities. These findings were supported by many, but not all observational studies. Recently there have been two main debated questions. The first one is whet...

  18. Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis

    OpenAIRE

    Gabbay-Benziv, Rinat; Reece, E. Albert; Wang, Fang; Yang, Peixin

    2015-01-01

    Currently, 60 million women of reproductive age (18-44 years old) worldwide, and approximately 3 million American women have diabetes mellitus, and it has been estimated that this number will double by 2030. Pregestational diabetes mellitus (PGD) is a significant public health problem that increases the risk for structural birth defects affecting both maternal and neonatal pregnancy outcome. The most common types of human structural birth defects associated with PGD are congenital heart defec...

  19. An exploratory analysis of the relationship between ambient ozone and particulate matter concentrations during early pregnancy and selected birth defects in Texas

    International Nuclear Information System (INIS)

    We performed an exploratory analysis of ozone (O3) and fine particulate matter (PM2.5) concentrations during early pregnancy and multiple types of birth defects. Data on births were obtained from the Texas Birth Defects Registry (TBDR) and the National Birth Defects Prevention Study (NBDPS) in Texas. Air pollution concentrations were previously determined by combining modeled air pollution concentrations with air monitoring data. The analysis generated hypotheses for future, confirmatory studies; although many of the observed associations were null. The hypotheses are provided by an observed association between O3 and craniosynostosis and inverse associations between PM2.5 and septal and obstructive heart defects in the TBDR. Associations with PM2.5 for septal heart defects and ventricular outflow tract obstructions were null using the NBDPS. Both the TBDR and the NBPDS had inverse associations between O3 and septal heart defects. Further research to confirm the observed associations is warranted. - Highlights: • Air pollution concentrations combined modeled air data and air monitoring data. • No associations were observed between the majority of birth defects and PM2.5 and O3. • Estimated associations between PM2.5 and certain heart defects varied by dataset. • Results were suggestive of an inverse association between O3 and septal heart defects. • Higher O3 concentrations may be associated with increased odds of craniosynostosis. - Although most observed associations between ozone and fine particulate matter concentrations and birth defects were null, some were present and warrant further consideration

  20. Birth defects after early pregnancy use of antithyroid drugs

    DEFF Research Database (Denmark)

    Andersen, Stine Linding; Olsen, Jørn; Wu, Chunsen;

    2013-01-01

    OR of birth defects. MMI/CMZ and PTU were associated with urinary system malformation, and PTU with malformations in the face and neck region. Choanal atresia, esophageal atresia, omphalocele, omphalomesenteric duct anomalies, and aplasia cutis were common in MMI/CMZ-exposed children (combined, adjusted...

  1. International retrospective cohort study of neural tube defects in relation to folic acid recommendations : are the recommendations working?

    NARCIS (Netherlands)

    Botto, LD; Lisi, A; Robert-Gnansia, E; Erickson, JD; Vollset, SE; Mastroiacovo, P; Botting, B; Cocchi, G; de Vigan, C; de Walle, H; Feijoo, M; Irgens, LM; McDonnell, B; Merlob, P; Ritvanen, A; Scarano, G; Siffel, C; Metneki, J; Stoll, C; Smithells, R; Goujard, J

    2005-01-01

    Objective To evaluate the effectiveness of policies and recommendations on folic acid aimed at reducing the occurrence of neural tube defects. Design Retrospective cohort study of births monitored by birth defect registries. Setting 13 birth defects registries monitoring rates of neural tube defects

  2. Parental mental illness and fatal birth defects in a national birth cohort

    DEFF Research Database (Denmark)

    Webb, Roger; Pickles, A.R.; King-Hele, Sarah;

    2007-01-01

    BACKGROUND: Few large studies describe links between maternal mental illness and risk of major birth defect in offspring. Evidence is sparser still for how effects vary between maternal diagnoses and no previous study has assessed risk with paternal illnesses.MethodA population-based birth cohort...... genetic effects directly linked with maternal illness, lifestyle factors (diet, smoking, alcohol and drugs), poor antenatal care, psychotropic medication toxicity, and gene-environment interactions. Further research is needed to elucidate the causal mechanisms...

  3. The Survey of Birth Defects Rate Based on Birth Registration System

    Institute of Scientific and Technical Information of China (English)

    Min Yu; Zhiguang Ping; Shuiping Zhang; Yuying He; Rui Dong; Xiong Guo

    2015-01-01

    Background:To investigate the surveillance trend of birth defects,incidence,distribution,occurrence regularity,and their relevant factors in Xi'an City in the last 10 years for proposing control measures.Methods:The birth defects monitoring data of infants during perinatal period (28 weeks of gestation to 7 days after birth) were collected from obstetrics departments of all hospitals during 2003-2012.Microsoft Excel 2003 was used for data input,and Statistical Package for the Social Sciences version 16.0 (International Business Machines Corporation,New York,NY,USA) was used for descriptive analysis.x2 test,Spearman correlation and linear-by-linear association trend test were used for statistical analyses.Results:The birth defect rate declined from 9.18% in 2003 to 7.00% in 2012 (x2 =45.00 l,P < 0.01) with a mean value of 7.85%,which is below the Chinese national average level (x2 =20.451,P < 0.01).The order of five most common birth defects has changed.The incidence of congenital heart disease (CHD) increased with time,particularly after 2012,it became the most frequent type (rs =0.808,P < 0.001).Till then,the number of neural tube defects (NTDs) declined significantly (x2 =76.254,P < 0.01).The average birth defects rate of 8.11% in rural areas was higher than that in urban areas (7.56%,x2 =7.919,P < 0.01) and much higher in males (8.28%) than that in females (7.18%,x2 =32.397,P < 0.0 1).Maternal age older than 35 years (x2 =35.298,P < 0.01) is the most dangerous age bracket of birth defects than maternal age younger than 20 years (x2 =7.128,P < 0.0l).Conclusions:A downward trend of birth defects was observed in Xi'an City from 2003 to 2012.NTDs significantly decreased after large-scale supplemental folic acid intervention,while the incidence rate of CHD significantly increased.

  4. Birth defects in pregestational diabetes: Defect range,glycemic threshold and pathogenesis

    Institute of Scientific and Technical Information of China (English)

    Rinat Gabbay-Benziv; E Albert Reece; Fang Wang, Peixin Yang

    2015-01-01

    Currently, 60 million women of reproductive age(18-44 years old) worldwide, and approximately 3million American women have diabetes mellitus, andit has been estimated that this number will doubleby 2030. Pregestational diabetes mellitus (PGD) is asignificant public health problem that increases therisk for structural birth defects affecting both maternaland neonatal pregnancy outcome. The most commontypes of human structural birth defects associated withPGD are congenital heart defects and central nervoussystem defects. However, diabetes can induce birthdefects in any other fetal organ. In general, the rateof birth defects increases linearly with the degree ofmaternal hyperglycemia, which is the major factor thatmediates teratogenicity of PGD. Stringent prenatal careand glycemic control are effective means to reducebirth defects in PGD pregnancies, but cannot reducethe incidence of birth defects to the rate of that is seenin the nondiabetic population. Studies in animal modelshave revealed that PGD induces oxidative stress,which activates cellular stress signalling leading todysregulation of gene expression and excess apoptosisin the target organs, including the neural tube andembryonic heart. Activation of the apoptosis signalregulatingkinase 1 (ASK1)-forkhead transcription factor3a (FoxO3a)-caspase 8 pathway causes apoptosis in thedeveloping neural tube leading to neural tube defects(NTDs). ASK1 activates the c-Jun-N-Terminal kinase1/2 (JNK1/2), which leads to activation of the unfoldedprotein response and endoplasmic reticulum (ER) stress.Deletion of the ASK1 gene, the JNK1 gene, or the JNK2gene, or inhibition of ER stress by 4-Phenylbutyric acidabrogates diabetes-induced apoptosis and reduces theformation of NTDs. Antioxidants, such as thioredoxin,which inhibits the ASK1-FoxO3a-caspase 8 pathway orER stress inhibitors, may prevent PGD-induced birthdefects. Gabbay-Benziv R et al . Birth defects in pregestational diabetes

  5. Prenatal Nitrate Intake from Drinking Water and Selected Birth Defects in Offspring of Participants in the National Birth Defects Prevention Study

    OpenAIRE

    Brender, Jean D; Weyer, Peter J.; Romitti, Paul A.; Mohanty, Binayak P.; Shinde, Mayura U; Vuong, Ann M; Sharkey, Joseph R.; Dwivedi, Dipankar; Horel, Scott A; Kantamneni, Jiji; Huber, John C; Zheng, Qi; Werler, Martha M.; Kelley, Katherine E.; Griesenbeck, John S.

    2013-01-01

    Background: Previous studies of prenatal exposure to drinking-water nitrate and birth defects in offspring have not accounted for water consumption patterns or potential interaction with nitrosatable drugs. Objectives: We examined the relation between prenatal exposure to drinking-water nitrate and selected birth defects, accounting for maternal water consumption patterns and nitrosatable drug exposure. Methods: With data from the National Birth Defects Prevention Study, we linked addresses o...

  6. Birth defects monitoring in underdeveloped countries: an example from Uruguay.

    Science.gov (United States)

    Castilla, E E; Lopez-Camelo, J S; Dutra, G P; Paz, J E

    1991-01-01

    Medical authorities in developing countries are primarily interested in nutritional and infectious diseases. Therefore, activities directed to the prevention and control of low priority illnesses, such as birth defects, need to be particularly effective, simple, and economical. Monitoring of congenital anomalies is one of the preventive activities which can be efficiently performed at very low cost. Guidelines for this are given, and their application exemplified by the case of Uruguay. Uruguay has recently attained an infant mortality rate of 20/1,000, with the congenital anomalies ranking as its second cause. The government of Uruguay, through the Pan American Health Organisation/World Health Organisation (PARO/WHO) called the Estudio Colaborativo Latino Americano de Malformaciones Congenitas (ECLAMC) for advice in order to plan a program for the prevention of birth defects. The recommendations given were based on conclusions drawn from the analysis of data the ECLAMC program has been accumulating, from Uruguay and other Latin-American countries, since 1967. The case of Uruguay clearly indicates that sensible guidelines for birth defects prevention can be provided, after working with this "low priority and uninteresting" group of illnesses for more than twenty years.

  7. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and the risk of selected birth defects: a prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Marleen M H J van Gelder

    Full Text Available BACKGROUND: Since use of non-steroidal anti-inflammatory drugs (NSAIDs during pregnancy is common, small increases in the risk of birth defects may have significant implications for public health. Results of human studies on the teratogenic risks of NSAIDs are inconsistent. Therefore, we evaluated the risk of selected birth defects after prenatal exposure to prescribed and over-the-counter NSAIDs. METHODS AND FINDINGS: We used data on 69,929 women enrolled in the Norwegian Mother and Child Cohort Study between 1999 and 2006. Data on NSAID exposure were available from a self-administered questionnaire completed around gestational week 17. Information on pregnancy outcome was obtained from the Medical Birth Registry of Norway. Only birth defects suspected to be associated with NSAID exposure based upon proposed teratogenic mechanisms and previous studies were included in the multivariable logistic regression analyses. A total of 3,023 women used NSAIDs in gestational weeks 0-12 and 64,074 women did not report NSAID use in early pregnancy. No associations were observed between overall exposure to NSAIDs during pregnancy and the selected birth defects separately or as a group (adjusted odds ratio 0.7, 95% confidence interval 0.4-1.1. Associations between maternal use of specific types of NSAIDs and the selected birth defects were not found either, although an increased risk was seen for septal defects and exposure to multiple NSAIDs based on small numbers (2 exposed cases; crude odds ratio 3.9, 95% confidence interval 0.9-15.7. CONCLUSIONS: Exposure to NSAIDs during the first 12 weeks of gestation does not seem to be associated with an increased risk of the selected birth defects. However, due to the small numbers of NSAID-exposed infants for the individual birth defect categories, increases in the risks of specific birth defects could not be excluded.

  8. Maternal Residential Exposure to Agricultural Pesticides and Birth Defects in a 2003 to 2005 North Carolina Birth Cohort

    Science.gov (United States)

    Birth defects are responsible for a large proportion of disability and infant mortality. Exposure to a variety of pesticides have been linked to increased risk of birth defects. We conducted a case-control study to estimate the associations between a residence-based metric of agr...

  9. The primary prevention of birth defects: Multivitamins or folic acid?

    Directory of Open Access Journals (Sweden)

    2004-03-01

    Full Text Available Periconceptional use of folic acid alone or in multivitamin supplements is effective for the primary prevention of neural-tube defects. The Hungarian randomized and two-cohort controlled trials showed that periconceptional multivitamin supplementation can reduce the occurrence of some other structural birth defects, i.e. congenital abnormalities. These findings were supported by many, but not all observational studies. Recently there have been two main debated questions. The first one is whether the use of folic acid alone or folic acid-containing multivitamins is better. The second one is connected with the dilemma of whether high dose of folic acid (e.g. 5 mg might be better than a daily multivitamin with 0.4 – 0.8 mg of folic acid. Comparison of the pooled data of two Hungarian trials using a multivitamin containing 0.8 mg folic acid and the data of the Hungarian Case-Control Surveillance of Congenital Abnormalities using high dose of folic acid seemed to be appropriate to answer these questions. Multivitamins containing 0.4 – 0.8 mg of folic acid were more effective for the reduction of neural-tube defects than high dose of folic acid. Both multivitamins and folic acid can prevent some part of congenital cardiovascular malformations. Only multivitamins were able to reduce the prevalence at birth of obstructive defects of urinary tract, limb deficiencies and congenital pyloric stenosis. However, folic acid was effective in preventing some part of rectal/anal stenosis/atresia, and high dose of folic acid had effect in preventing some orofacial clefts. The findings are consistent that periconceptional multivitamin and folic acid supplementation reduce the overall occurrence of congenital abnormalities in addition to the demonstrated effect on neural-tube defects.

  10. The primary prevention of birth defects: Multivitamins or folic acid?

    Science.gov (United States)

    Czeizel, Andrew E

    2004-01-01

    Periconceptional use of folic acid alone or in multivitamin supplements is effective for the primary prevention of neural-tube defects. The Hungarian randomized and two-cohort controlled trials showed that periconceptional multivitamin supplementation can reduce the occurrence of some other structural birth defects, i.e. congenital abnormalities. These findings were supported by many, but not all observational studies. Recently there have been two main debated questions. The first one is whether the use of folic acid alone or folic acid-containing multivitamins is better. The second one is connected with the dilemma of whether high dose of folic acid (e.g. 5 mg) might be better than a daily multivitamin with 0.4 - 0.8 mg of folic acid. Comparison of the pooled data of two Hungarian trials using a multivitamin containing 0.8 mg folic acid and the data of the Hungarian Case-Control Surveillance of Congenital Abnormalities using high dose of folic acid seemed to be appropriate to answer these questions. Multivitamins containing 0.4 - 0.8 mg of folic acid were more effective for the reduction of neural-tube defects than high dose of folic acid. Both multivitamins and folic acid can prevent some part of congenital cardiovascular malformations. Only multivitamins were able to reduce the prevalence at birth of obstructive defects of urinary tract, limb deficiencies and congenital pyloric stenosis. However, folic acid was effective in preventing some part of rectal/anal stenosis/atresia, and high dose of folic acid had effect in preventing some orofacial clefts. The findings are consistent that periconceptional multivitamin and folic acid supplementation reduce the overall occurrence of congenital abnormalities in addition to the demonstrated effect on neural-tube defects. PMID:15912190

  11. Genetic link between renal birth defects and congenital heart disease.

    Science.gov (United States)

    San Agustin, Jovenal T; Klena, Nikolai; Granath, Kristi; Panigrahy, Ashok; Stewart, Eileen; Devine, William; Strittmatter, Lara; Jonassen, Julie A; Liu, Xiaoqin; Lo, Cecilia W; Pazour, Gregory J

    2016-01-01

    Structural birth defects in the kidney and urinary tract are observed in 0.5% of live births and are a major cause of end-stage renal disease, but their genetic aetiology is not well understood. Here we analyse 135 lines of mice identified in large-scale mouse mutagenesis screen and show that 29% of mutations causing congenital heart disease (CHD) also cause renal anomalies. The renal anomalies included duplex and multiplex kidneys, renal agenesis, hydronephrosis and cystic kidney disease. To assess the clinical relevance of these findings, we examined patients with CHD and observed a 30% co-occurrence of renal anomalies of a similar spectrum. Together, these findings demonstrate a common shared genetic aetiology for CHD and renal anomalies, indicating that CHD patients are at increased risk for complications from renal anomalies. This collection of mutant mouse models provides a resource for further studies to elucidate the developmental link between renal anomalies and CHD. PMID:27002738

  12. Application Research of "3+1" Mode for Birth Defects Monitoring

    Institute of Scientific and Technical Information of China (English)

    Hong LIU; Cheng-liang XIONG

    2008-01-01

    Objective To explore the "3+1" monitoring mode for birth defects and quality control measures based on the population,and to obtain the related information data for birth defects.Methods With the community population as the basis,adopting the unified monitoring scheme dominant by the leadership and administration of government,with districts(counties)as the monitoring sites,the "3+1" monitoring mode for birth defects was based on a complete monitoring team with the combination of villages/residents'committees,townships(towns),counties(districts)and the municipality.Demonstration research was carried out in the pilot districts/counties in Chongqing City.Results Birth defects population monitoring system based on population and family planning management and service network was established,and during 2005 and 2006,application research was carried out for the monitoring methods among birth deflects population in the pilot districts(counties),obtaining the relevant information in regional birth defects,with a monitoring coverage of over 99%.Conclusion Fully utilizing the birth management functions of Population and Family Planning System and the advantages of service networks,long term,dynamic birth defects monitoring system based on community population was established,with the integration of birth defects monitoring and regular reproductive health services,obtaining overall birth defects occurrence information in details,providing scientific basis for the government to formulate scientific,practical,economic and effective birth defects intervention policy,so as to improve the quality of the population.

  13. Interaction between epidemiology and laboratory sciences in the study of birth defects: Design of birth defects risk factor surveillance in metropolitan Atlanta

    Energy Technology Data Exchange (ETDEWEB)

    Lynberg, M.C.; Khoury, M.J. (Dept. of Health and Human Services, Atlanta, GA (United States))

    1993-01-01

    Despite years of research, the etiology of most birth defects remains largely unknown. Interview instruments have been the major tools in the search for environmental causes of birth defects. Because of respondents' problems with recognition and recall, interviews are limited in their capacity to measure certain exposures. Laboratory scientists can have a major impact on defining markers of environmental exposure and genetic susceptibility. The Centers for Disease Control is starting a case-control study of serious birth defects on the basis of a population-based surveillance system for birth defects diagnosed during the first year of life in metropolitan Atlanta, Each year, 300 infants with selected birth defects (case subjects) and 100 population-based control subjects (infants without birth defects) will be enrolled in an ongoing study that will supplement surveillance. In addition to conducting extensive maternal interviews, we will collect blood and urine specimens from case and control subjects and their mothers for laboratory testing. Eventually, some environmental sampling may be incorporated. Particular areas of emphasis are (1) nutritional factors, specifically measuring maternal folic acid levels and other micronutrients (e.g., zinc) to explore their role in the etiology of neural tube defects, (2) substance use, specifically measuring cocaine metabolites in the blood and urine to explore their role for specific vascular disruption defects, and (3) environmental factors such as pesticides and aflatoxins, to explore their potential relationships with specific defects. In addition, a DNA bank will be maintained to evaluate the role of specific candidate genes in the etiology of birth defects. The development and testing of these methods could be useful to assess the interaction between environmental exposures and genetic susceptibility in the etiology of birth defects. 15 refs., 1 fig., 1 tab.

  14. Increasing trends in childlessness in recent birth cohorts - a registry-based study of the total Danish male population born from 1945 to 1980

    DEFF Research Database (Denmark)

    Priskorn, Lærke; Holmboe, Stine; Jacobsen, R;

    2012-01-01

    The fertility rate has recently declined in many parts of the World, including Europe. To a large extent, this change can be explained by the socio-economic development. However, increasing fertility problems and widespread occurrence of poor semen quality could in part explain the few births...... and contained information from The National Danish Birth Registry and The Danish In Vitro Fertilization (IVF) Registry. For consecutive birth cohorts of native Danish men cumulative fertility rates at age 45 declined from 1.91 children per man in the 1945 birth cohort to 1.71 for men born in 1960...... showed that the proportion remaining childless throughout life has been lower than in men and has not shown a similar increase. In conclusion, using unique Danish registries the study showed a birth cohort related decline in fertility rates and an increase in childlessness among men. In the more recent...

  15. Agrichemicals in surface water and birth defects in the United States

    OpenAIRE

    Winchester, Paul D; Huskins, Jordan; Ying, Jun

    2009-01-01

    Objectives: To investigate if live births conceived in months when surface water agrichemicals are highest are at greater risk for birth defects. Methods: Monthly concentrations during 1996–2002 of nitrates, atrazine and other pesticides were calculated using United States Geological Survey's National Water Quality Assessment data. Monthly United States birth defect rates were calculated for live births from 1996 to 2002 using United States Centers for Disease Control and Prevention natality ...

  16. Birth defects in Iraq and the plausibility of environmental exposure: A review

    OpenAIRE

    Al-Hadithi Tariq S; Al-Diwan Jawad K; Saleh Abubakir M; Shabila Nazar P

    2012-01-01

    Abstract An increased prevalence of birth defects was allegedly reported in Iraq in the post 1991 Gulf War period, which was largely attributed to exposure to depleted uranium used in the war. This has encouraged further research on this particular topic. This paper reviews the published literature and provided evidence concerning birth defects in Iraq to elucidate possible environmental exposure. In addition to published research, this review used some direct observation of birth defects dat...

  17. Birth Order and Health of Newborns: What Can We Learn from Danish Registry Data?

    OpenAIRE

    Brenøe, Anne Ardila; Molitor, Ramona

    2016-01-01

    Research has shown a strong negative correlation between birth order and cognitive test scores, IQ, and educational outcomes. We ask whether birth order differences in health are present at birth using matched administrative data for more than 1,000,000 children born in Denmark between 1981 and 2010. Using family fixed effects models, we find a positive and robust birth order effect; earlier born children are less healthy at birth. Looking at the potential mechanisms, we find that during earl...

  18. Folic acid and primary prevention of birth defects.

    Science.gov (United States)

    Taruscio, Domenica; Carbone, Pietro; Granata, Orietta; Baldi, Francesca; Mantovani, Alberto

    2011-01-01

    Birth defects (BDs) are an important public health problem, due to their overall incidence, occurring in 2-3% of live births in European Union. Neural tube defects (NTDs) are among major NTDs, due to their severity and relatively high incidence; in the meanwhile NTDs are also the most effectively preventable BDs to date. In particular, an adequate folic acid (FA) intake reduces both the occurrence and the recurrence of NTDs; FA is the synthetic form of folates, naturally occurring vitamins in a number of foods, especially vegetables. The daily intake of 0.4 mg of FA should be recommended to all women of childbearing age who plan to become pregnant. The Italian Network for Primary Prevention of BDs through FA Promotion has achieved a significant improvement in FA awareness and use in the periconceptional period. Nevertheless, primary prevention of BDs needs to make further progress; the Italian National Centre for Rare Diseases participates in european sureveillance of congenital anomalies (EUROCAT) Joint Action as coordinator of activities on the effectiveness of BDs prevention. Mandatory food fortification with FA has not been introduced in any European country. The health benefits of FA in reducing the risk of NTDs are undisputed; however mechanistic and animal studies suggest a relationship between high FA intakes and increased cancer promotion, while human studies are still inconsistent and inconclusive. A Working Group organized by the European Food Safety Authority pointed out significant uncertainties about fortification safety and the need for more studies; currently, FA intake from fortified foods and supplements should not exceed 1 mg/day in adults. In conclusion, based on up-to-date scientific evidence, the Italian Network strategy pivots on periconceptional supplementation integrated with promotion of healthy eating habits, support to health education, enhancing the role of women in managing life choices about their health and pregnancy and increasing

  19. Epidemiology of Birth Defects Based on a Birth Defect Surveillance System from 2005 to 2014 in Hunan Province, China.

    Directory of Open Access Journals (Sweden)

    Donghua Xie

    Full Text Available To describe the epidemiology of birth defects (BDs in perinatal infants in Hunan Province, China, between 2005 and 2014.The BD surveillance data of perinatal infants (for stillbirth, dead fetus or live birth between 28 weeks of gestation and 7 days after birth were collected from 52 registered hospitals of Hunan between 2005 and 2014. The prevalence rates of BDs with 95% confidence interval (CI and crude odds ratio (ORs were calculated to examine the associations of infant gender, maternal age, and region (urban vs rural with BDs.From 2005 to 2014, there were a total of 925413 perinatal infants of which 17753 had BDs, with the average prevalence of 191.84 per 10000 PIs (perinatal infants, showing a significant uptrend. The risks of BDs are higher in urban areas versus rural areas (OR = 1.20, in male infants versus female infants (OR = 1.19, and in mothers above age 35 versus those below age 35 (OR = 1.24. The main five types of BDs are Congenital heart defects (CHD, Other malformation of external ear (OMEE, Polydactyly, Congenital malformation of kidney (CMK, and Congenital talipes equinovarus (CTE. From 2005 to 2014, the prevalence rates (per 10000 PIs of CHD and CMK increased significantly from 22.56 to 74 (OR = 3.29, 95%CI: 2.65-4.11 and from 7.61 to 14.62 (OR = 1.92, 95%CI:1.30-2.84, respectively; the prevalence rates of congenital hydrocephalus and neural tube defects (NTDs decreased significantly from 11.8 to 5.29 (OR = 0.45, 95%CI: 0.31-0.65 and from 7.87 to 1.74 (OR = 0.22, 95%CI: 0.13-0.38, respectively.The prevalence rates of specific BDs in perinatal infants in Hunan have changed in the last decade. Urban pregnant women, male perinatal infants, and mothers above age 35 present different prevalence rates of BDs. Wider use of new diagnosis technology, improving the ability of monitoring, strengthening the publicity and education are important to reduce the prevalence of BDs.

  20. Zika virus and birth defects: an obstetric issue

    Directory of Open Access Journals (Sweden)

    Tochukwu C. Okeke

    2016-08-01

    Full Text Available Zika virus is an emerging mosquito-borne virus that is relatively unknown, unstudied and under-diagnosed, but has potentials to spread to new geographical areas that favour survival of Aedes mosquitoes. It is associated with an alarming rise in babies with microcephaly that require much care and support with a lot of financial assistance. This is a review article on Zika virus and birth defects; a worrisome issue in today's obstetric and medical practices. Since Zika's discovery in Uganda, the virus was known to occur within a narrow equatorial belt from Africa to Asia with no or mild symptoms. It has emerged as a global public health threat over the last decade with accelerated geographic spread of the virus in the last nine years. The risk of Zika virus to the fetus is poorly understood, difficult to quantify and problematic. The causal link between Zika virus and microcephaly was initially speculative, strongly suspected and scientifically unproven. However, on 13th April, 2016, it was concluded that Zika virus is the cause of microcephaly and other severe fetal brain defects. The Center for Disease Control and Prevention (CDC authors reviewed and weighed evidences using established scientific criteria to conclude after a careful review of the report published in the New England Journal of Medicine. There is no prophylaxis, treatment or vaccine to protect against Zika virus infection. However, preventive personal measures are highly recommended to avoid mosquito bites. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2488-2496

  1. Cancer risk in children and adolescents with birth defects: a population-based cohort study.

    Directory of Open Access Journals (Sweden)

    Lorenzo D Botto

    Full Text Available OBJECTIVE: Birth defects are an increasing health priority worldwide, and the subject of a major 2010 World Health Assembly Resolution. Excess cancer risk may be an added burden in this vulnerable group of children, but studies to date have provided inconsistent findings. This study assessed the risk for cancer in children and young adolescents with major birth defects. METHODS AND FINDINGS: This retrospective, statewide, population-based, cohort study was conducted in three US states (Utah, Arizona, Iowa. A cohort of 44,151 children and young adolescents (0 through 14 years of age with selected major, non-chromosomal birth defects or chromosomal anomalies was compared to a reference cohort of 147,940 children without birth defects randomly sampled from each state's births and frequency matched by year of birth. The primary outcome was rate of cancer prior to age 15 years, by type of cancer and type of birth defect. The incidence of cancer was increased 2.9-fold (95% CI, 2.3 to 3.7 in children with birth defects (123 cases of cancer compared to the reference cohort; the incidence rates were 33.8 and 11.7 per 100,000 person-years, respectively. However, the excess risk varied markedly by type of birth defect. Increased risks were seen in children with microcephaly, cleft palate, and selected eye, cardiac, and renal defects. Cancer risk was not increased with many common birth defects, including hypospadias, cleft lip with or without cleft palate, or hydrocephalus. CONCLUSION: Children with some structural, non-chromosomal birth defects, but not others, have a moderately increased risk for childhood cancer. Information on such selective risk can promote more effective clinical evaluation, counseling, and research.

  2. Birth Order and Health of Newborns: What Can We Learn from Danish Registry Data?

    DEFF Research Database (Denmark)

    Brenøe, Anne Ardila; Molitor, Ramona

    2016-01-01

    We ask whether birth order differences in health are present at birth using matched administrative data for more than 1 million children born in Denmark between 1981 and 2010. Using family fixed effects models, we find a positive and robust birth order effect; lower parity children are less healthy...... at birth. Looking at the potential mechanisms, we find that during earlier pregnancies women have higher labor market attachment, are more likely to smoke, receive more prenatal care, and are diagnosed with more medical pregnancy complications. Yet, none of these factors explain the birth order...... differences at birth. Data on hospital admissions reveal that the health advantage of higher parity children persists in the first years of life and disappears by age 7....

  3. Epidemiology of birth defects, perinatal mortality and thyroid cancer before and after the Chernobyl catastrophe

    International Nuclear Information System (INIS)

    Spatial and temporal trends of birth defects and perinatal mortality in Germany and Europe as well as in least and most contaminated regions have been compared and investigated by trends. In numerous data sets, especially from northern and eastern Europe, positive and significant trend variations with upward 'disturbances' in temporal relation associated with the Chernobyl accident 1986 have been identified and spatial associations with regional fallout have been found. A surprisingly consistent picture evolves of significantly raised stillbirth rates after Chernobyl of ca. 5 % in Poland, ca. 10 % in parts of Germany and Sweden, ca. 20 % in Denmark and Finland, and up to ca. 30% in Iceland and Hungary. Low as compared to higher contaminated regions show weaker or stronger effects, respectively. The additional relative risks for birth defects are in the same order of magnitude as the additional relative risks for stillbirth, namely 0,5%-20 %/kBq·m2. Using well-known conversion coefficients, the excess relative risk of 1 %/kBq·m2 translates theoretically to a preliminary relative risk of 1,6/mSv/a. The incidence of thyroid carcinoma among children affected by Chernobyl fallout has increased dramatically in certain parts of Europe. Less evidence exists for a similar effect among adolescents and adults. The cancer registry of the Czech Republic provides an opportunity to study various determinants of the occurrence of thyroid cancer. After the Chernobyl accident, the thyroid cancer incidence of the Czech Republic reveals an additional annual increase of up to 5% depending on age and gender. The additional increases of thyroid cancer in the whole population of the Czech Republic are consistent with reports from other countries. To investigate trends in the sex distribution of newborns before and after the Chernobyl accident, gender-specific annual birth statistics were obtained from the Czech Republic, Denmark, Finland, Germany, Hungary, Norway, Poland, and Sweden

  4. Links between environmental geochemistry and rate of birth defects: Shanxi Province, China

    International Nuclear Information System (INIS)

    The rate of birth defects in Shanxi Province is among the highest worldwide. In order to identify the impacts of geochemical and environmental factors on birth defect risk, samples of soil, water and food were collected from an area with an unusually high rate of birth defects (study area) and an area with a low rate of birth defects (control area) in Shanxi Province, China. Element contents were determined by ICP-OES, and the results were analyzed using a non-parametric test and stepwise regression. Differences in the level and distribution of 14 geochemical elements, namely arsenic (As), selenium (Se), molybdenum (Mo), zinc (Zn), strontium (Sr), iron (Fe), tin (Sn), magnesium (Mg), vanadium (V), calcium (Ca), copper (Cu), aluminum (Al), potassium (K) and sulfur (S) were thus compared between the study and control areas. The results reveal that the geochemical element contents in soil, water and food show a significant difference between the study area and control area, and suggest that the study area was characterized by higher S and lower Sr and Al contents. These findings, based on statistical analysis, may be useful in directing further epidemiological investigations identifying the leading causes of birth defects. - Research Highlights: → Environmental geochemistry has an significant impact on birth defects in the regions with an unusually high rate of birth defects. → An excess of S and deficiency of Sr and Al are the distinctive environmental features associated with the high rate of birth defects in the Shanxi Province of China. → Geochemical anomalies is a non-medical basis for effective prevention and cure of birth defects.

  5. Increasing trends in childlessness in recent birth cohorts - a registry-based study of the total Danish male population born from 1945 to 1980.

    Science.gov (United States)

    Priskorn, L; Holmboe, S A; Jacobsen, R; Jensen, T K; Lassen, T H; Skakkebaek, N E

    2012-06-01

    The fertility rate has recently declined in many parts of the World, including Europe. To a large extent, this change can be explained by the socio-economic development. However, increasing fertility problems and widespread occurrence of poor semen quality could in part explain the few births. The objective of this registry based study was to investigate birth cohort related trends in fertility and childlessness among Danish men. The study population comprised all 1 616 677 men in Denmark born from 1945 to 1980 of whom 1 359 975 (84.1%) were native Danes. Data were obtained from Statistics Denmark and contained information from The National Danish Birth Registry and The Danish In Vitro Fertilization (IVF) Registry. For consecutive birth cohorts of native Danish men cumulative fertility rates at age 45 declined from 1.91 children per man in the 1945 birth cohort to 1.71 for men born in 1960. The proportion of childless men at age 45 increased from 14.8% to 21.9% in the same birth cohorts. Assisted reproductive technology (ART) seemed to compensate partly for the lower fertility and to reduce the proportion of childless men. In contrast, recent reports on corresponding birth cohorts of Danish women showed that the proportion remaining childless throughout life has been lower than in men and has not shown a similar increase. In conclusion, using unique Danish registries the study showed a birth cohort related decline in fertility rates and an increase in childlessness among men. In the more recent cohorts more than one in five men remained childless. The causes behind the findings are likely multi-factorial. Hitherto, most attention has been given to socio-economic factors which undoubtedly play a major role. Our findings lend support to the hypothesis that the high prevalence of low sperm counts among young Danish men may be a contributing factor.

  6. Maternal exposure to methotrexate and birth defects: a population-based study.

    Science.gov (United States)

    Dawson, April L; Riehle-Colarusso, Tiffany; Reefhuis, Jennita; Arena, J Fernando

    2014-09-01

    Methotrexate is an anti-folate medication that is associated with increased risk of multiple birth defects. Using data from the National Birth Defects Prevention Study, a case-control study of major birth defects in the United States, we examined mothers exposed to methotrexate. The study population included mothers of live-born infants without major birth defects (controls) and mothers of fetuses or infants with a major birth defect (cases), with expected dates of delivery between October 1997 and December 2009. Mothers of cases and controls were asked detailed questions concerning pregnancy history, demographic information, and exposures in a telephone interview. Approximately 0.06% (n = 16/27,623) of case and 0.04% (n = 4/10,113) of control mothers reported exposure to methotrexate between 3 months prior to conception through the end of pregnancy. Of the 16 case infants, 11 (68.8%) had a congenital heart defect (CHD). The observed CHDs included atrial septal defects, tetralogy of Fallot, valvar pulmonary stenosis, ventricular septal defects (VSDs), and total anomalous pulmonary venous return. One case infant had microtia in addition to a VSD and another had VACTER association. Exposed cases without a CHD had one of the following birth defects: cleft palate, hypospadias, congenital diaphragmatic hernia, or craniosynostosis. Based on a limited number of methotrexate-exposed mothers, our findings support recent case reports suggesting an association between early pregnancy exposure to methotrexate and CHDs. Because of the rarity of maternal periconceptional exposure to methotrexate, long-term, population-based case-control studies are needed to confirm these findings and better evaluate the association between methotrexate and birth defects.

  7. Heart Birth Defects Dropped After Folic Acid Was Added to Food

    Science.gov (United States)

    ... fullstory_160673.html Heart Birth Defects Dropped After Folic Acid Was Added to Food Canadian study found that ... Aug. 29, 2016 (HealthDay News) -- The introduction of folic acid-fortified foods in Canada was associated with a ...

  8. Pain, Epilepsy Drug Lyrica May Increase Birth Defects Risk, Study Suggests

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_158906.html Pain, Epilepsy Drug Lyrica May Increase Birth Defects Risk, Study ... prescribed for a range of health problems, including epilepsy, fibromyalgia and anxiety. The new study findings should ...

  9. Adding Folic Acid to Corn Masa Flour May Prevent Birth Defects

    Science.gov (United States)

    ... For Consumers Consumer Updates Adding Folic Acid to Corn Masa Flour May Prevent Birth Defects Share Tweet ... mainstay of their regular diets—which often are corn masa-based.” This could be a reason why ...

  10. Hypospadias and maternal exposure to atrazine via drinking water in the National Birth Defects Prevention study

    OpenAIRE

    Winston, Jennifer J.; Emch, Michael; Meyer, Robert E.; Langlois, Peter; Weyer, Peter; Mosley, Bridget; Olshan, Andrew F.; Band, Lawrence E.; Thomas J. Luben; ,

    2016-01-01

    Background Hypospadias is a relatively common birth defect affecting the male urinary tract. It has been suggested that exposure to endocrine disrupting chemicals might increase the risk of hypospadias by interrupting normal urethral development. Methods Using data from the National Birth Defects Prevention Study, a population-based case-control study, we considered the role of maternal exposure to atrazine, a widely used herbicide and potential endocrine disruptor, via drinking water in the ...

  11. Birth defects following maternal exposure to ergotamine, beta blockers, and caffeine.

    OpenAIRE

    Hughes, H E; Goldstein, D A

    1988-01-01

    Ergotamine exposure during pregnancy has been suggested to cause birth defects which have a vascular disruptive aetiology. The present case provides additional support for the possible adverse fetal effects of exposure to ergotamine, caffeine, and propranolol during the first four months of pregnancy. At birth the infant showed evidence of early arrested cerebral maturation and paraplegia. The nature of these defects suggests a primary vascular disruptive aetiology. We hypothesise that ergota...

  12. The Association of Maternal Lifestyle with Birth Defects in Shaanxi Province, Northwest China

    OpenAIRE

    Pei, Leilei; Kang, Yijun; Cheng, Yue; Yan, Hong

    2015-01-01

    Background The main objective was to investigate the burden of birth defects among alive infants and explore the impact of maternal lifestyle during pregnancy on the burden of birth defects in Northwest China. Methods A stratified multi-stage sampling method was used to study infants born during 2010–2013 (and their mothers) in Shaanxi province of Northwest China. Socio-demographic information was collected using a structured questionnaire, and medical records from the local hospitals were us...

  13. Parental Reactions to an Infant with a Birth Defect: A Study of Five Families.

    Science.gov (United States)

    Mintzer, Dorian

    Five families whose first born infant experienced a birth anomaly were followed for two years through a combination of home and laboratory visits. Findings suggested that the birth of an infant with a defect was experienced by the parents as a narcissistic injury and a series of narcissistic insults that affect the parents' self esteem, interfere…

  14. Folic acid sensitive birth defects in association with intrauterine exposure to folic acid antagonists

    NARCIS (Netherlands)

    Meijer, W.M.; Walle, H.E.K.de; Kerstjens-Frederikse, W.S; de Jong-van den Berg, Lolkje Theodora Wilhelmina

    2005-01-01

    Since the protective effect of folic acid (FA) on birth defects is well known, it is reasonable to assume intrauterine exposure to FA antagonists increases the risk on these defects. We have therefore performed case-control analyses to investigate the risk of intrauterine exposure to FA antagonists,

  15. DESCRIPTIVE CASES STUDY OF CARE, SURVEILLANCE AND PREVENTION OF BIRTH DEFECTS IN RWANDAN CHILDREN

    Directory of Open Access Journals (Sweden)

    JJ. Irakiza

    2014-09-01

    Full Text Available “According to the World Health Statistics 2008, about 260 000 neonatal deaths worldwide are caused by Congenital anomalies. This fiure represents about 7% of all neonatal deaths”. In our study, birth accounted Defects for 14.9% out of 581 recruited infants with birth defects (87 cases. In this series, 52.9% were Female whereas 47.1% were male.13.8% were premature babies (≤37weeks, 74.7% aged <5 months and 11.5% were infants aged between 5 and 12 months. Polymalformative conditions were the most common Cause of death identifid in 21 cases (24%, gastrointestinal birth defects caused death in 15 cases (17%, nervous system in 14 (16%, Cardio-vascular birth defects in 10 cases (12%, Chromosomal abnormalities In 10 cases (12%, musculoskeletal defects in 10 cases (12%, congenital mass in 2 cases (2%, oral defects in 2 cases (2%, congenital skin defect in 1 case(1%, whereas congenital respiratory defect and genitourinary malformations in 1 case each (1%.Over 50% patients died in referral hospitals and 77% died after 24 hours of life.

  16. The risk of birth defects in dichorionic twins conceived by assisted reproductive technology.

    Science.gov (United States)

    Kuwata, Tomoyuki; Matsubara, Shigeki; Ohkuchi, Akihide; Watanabe, Takashi; Izumi, Akio; Honma, Yoko; Yada, Yukari; Shibahara, Hiroaki; Suzuki, Mitsuaki

    2004-06-01

    The purpose of this study was to examine whether dichorionic twins conceived by assisted reproductive technology (ART; intracytoplasmic sperm injection [ICSI], in vitro fertilization [IVF], gamete-intrafallopian tube transfer [GIFT]) have a higher risk of birth defects compared to dichorionic twins conceived naturally. We reviewed the medical records of 406 mothers with dichorionic twin pregnancies, who received continuous antenatal care from or = 24 weeks of gestation in our institute. Birth defects were diagnosed at the time of hospital discharge according to the International Classification of Diseases, 10th Revision. Occurrence of birth defects was compared between twins conceived by ART and those conceived naturally using logistic regression analysis. Overall, 51 of 812 infants (51/812 = 6.2%) had birth defects. The incidence of birth defects in ART-conceived twins was significantly higher than that of naturally conceived twins with an odds ratio of 6.9 (95% confidence interval [CI] 2.1, 22.5), 3.7 (95% CI 1.2, 12.0), and 4.3 (95% CI 1.4, 14.3) for ICSI, IVF, and GIFT, respectively. The higher frequency of birth defects in ART-conceived twins was still significant after adjusting for higher maternal age in the ART group, with an adjusted odds ratio of 6.7 (95% CI 2.1, 21.9), 3.6 (95% CI 1.1, 11.5), and 3.7 (95% CI 1.2-11.8) for ICSI, IVF, and GIFT, respectively. Dichorionic twins conceived by ART, compared to dichorionic twins conceived naturally, had a much higher risk for birth defects diagnosed at hospital discharge. PMID:15193165

  17. Maternal occupation and the risk of major birth defects: a follow-up analysis from the National Birth Defects Prevention Study.

    Science.gov (United States)

    Lin, Shao; Herdt-Losavio, Michele L; Chapman, Bonnie R; Munsie, Jean-Pierre; Olshan, Andrew F; Druschel, Charlotte M

    2013-06-01

    This study further examined the association between selected maternal occupations and a variety of birth defects identified from prior analysis and explored the effect of work hours and number of jobs held and potential interaction between folic acid and occupation. Data from a population-based, multi-center case-control study was used. Analyses included 45 major defects and specific sub-occupations under five occupational groups: healthcare workers, cleaners, scientists, teachers and personal service workers. Both logistic regression and Bayesian models (to minimize type-1 errors) were used, adjusted for potential confounders. Effect modification by folic acid was also assessed. More than any other occupation, nine different defects were positively associated with maids or janitors [odds ratio (OR) range: 1.72-3.99]. Positive associations were also seen between the following maternal occupations and defects in their children (OR range: 1.35-3.48): chemists/conotruncal heart and neural tube defects (NTDs), engineers/conotruncal defects, preschool teachers/cataracts and cleft lip with/without cleft palate (CL/P), entertainers/athletes/gastroschisis, and nurses/hydrocephalus and left ventricular outflow tract heart defects. Non-preschool teachers had significantly lower odds of oral clefts and gastroschisis in their offspring (OR range: 0.53-0.76). There was a suggestion that maternal folic acid use modified the effects with occupations including lowering the risk of NTDs and CL/P. No consistent patterns were found between maternal work hours or multiple jobs by occupation and the risk of birth defects. Overall, mothers working as maids, janitors, biologists, chemists, engineers, nurses, entertainers, child care workers and preschool teachers had increased risks of several malformations and non-preschool teachers had a lower risk of some defects. Maternal folic acid use reduced the odds of NTDs and CL/P among those with certain occupations. This hypothesis

  18. Prevalence of birth defects and risk-factor analysis from a population-based survey in Inner Mongolia, China

    Directory of Open Access Journals (Sweden)

    Zhang Xingguang

    2012-08-01

    Full Text Available Abstract Background Birth Defects are a series of diseases that seriously affect children's health. Birth defects are generally caused by several interrelated factors. The aims of the article is to estimate the prevalence rate and types of birth defects in Inner Mongolia, China, to compare socio-demographic characteristics among the children with birth defects and to analyze the association between risk factors and birth defects. Methods Data used in this study were obtained through baseline survey of Inner Mongolia Birth Defects Program, a population-based survey conducted from 2005 to 2008. The survey used cluster sampling method in all 12 administrative districts of Inner Mongolia. Sampling size is calculated according to local population size at a certain percentage. All live births, stillbirths and abortions born from October 2005 to September 2008, whose families lived in Inner Mongolia at least one year, were included. The cases of birth defects were diagnosed by the clinical doctors according to their experiences with further laboratory tests if needed. The inclusion criteria of the cases that had already dead were decided according to death records available at local cites. We calculated prevalence rate and 95% confidence intervals of different groups. Outcome variable was the occurrence of birth defects and associations between risk factors and birth defects were analyzed by using Poisson regression analysis. Results 976 children with birth defects were diagnosed. The prevalence rate of birth defects was 156.1 per 10000 births (95%CI: 146.3-165.8. The prevalence rate of neural tube defect (20.1 per 10000 births including anencephaly(6.9 per 10000, spina bifida (10.6 per 10000, and encephalocele (2.7 per 10000 was the highest, followed by congenital heart disease (17.1 per 10000. The relative risk (RR for maternal age less than 25 was 2.22 (95%CI: 2.05, 2.41. The RR of the ethnic Mongols was lower than Han Chinese (RR: 0.84; 95%CI: 0

  19. Birth defects in Iraq and the plausibility of environmental exposure: A review

    Directory of Open Access Journals (Sweden)

    Al-Hadithi Tariq S

    2012-07-01

    Full Text Available Abstract An increased prevalence of birth defects was allegedly reported in Iraq in the post 1991 Gulf War period, which was largely attributed to exposure to depleted uranium used in the war. This has encouraged further research on this particular topic. This paper reviews the published literature and provided evidence concerning birth defects in Iraq to elucidate possible environmental exposure. In addition to published research, this review used some direct observation of birth defects data from Al-Ramadi Maternity and Paediatric Hospital in Al-Anbar Governorate in Iraq from1st July 2000 through 30th June 2002. In addition to depleted uranium other war-related environmental factors have been studied and linked directly or indirectly with the increasing prevalence of birth defects. However, the reviewed studies and the available research evidence do not provide a clear increase in birth defects and a clear indication of a possible environmental exposure including depleted uranium although the country has been facing several environmental challenges since 1980.

  20. Birth defects in Iraq and the plausibility of environmental exposure: A review.

    Science.gov (United States)

    Al-Hadithi, Tariq S; Al-Diwan, Jawad K; Saleh, Abubakir M; Shabila, Nazar P

    2012-01-01

    An increased prevalence of birth defects was allegedly reported in Iraq in the post 1991 Gulf War period, which was largely attributed to exposure to depleted uranium used in the war. This has encouraged further research on this particular topic. This paper reviews the published literature and provided evidence concerning birth defects in Iraq to elucidate possible environmental exposure. In addition to published research, this review used some direct observation of birth defects data from Al-Ramadi Maternity and Paediatric Hospital in Al-Anbar Governorate in Iraq from1st July 2000 through 30th June 2002. In addition to depleted uranium other war-related environmental factors have been studied and linked directly or indirectly with the increasing prevalence of birth defects. However, the reviewed studies and the available research evidence do not provide a clear increase in birth defects and a clear indication of a possible environmental exposure including depleted uranium although the country has been facing several environmental challenges since 1980. PMID:22839108

  1. High Prevalence of Associated Birth Defects in Congenital Hypothyroidism

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    Alok Sachan

    2010-01-01

    Full Text Available Aim. To identify dysmorphic features and cardiac, skeletal, and urogenital anomalies in patients with congenital hypothyroidism. Patients and Methods. Seventeen children with congenital primary hypothyroidism were recruited. Cause for congenital hypothyroidism was established using ultrasound of thyroid and T99mc radionuclide thyroid scintigraphy. Malformations were identified by clinical examination, echocardiography, X-ray of lumbar spine, and ultrasonography of abdomen. Results. Ten (59% patients (6 males and 4 females had congenital malformations. Two had more than one congenital malformation (both spina bifida and ostium secundum atrial septal defect. Five (29% had cardiac malformations, of whom three had only osteum secundum atrial septal defect (ASD, one had only patent ductus arteriosus (PDA, and one patient had both ASD and PDA. Seven patients (41% had neural tube defects in the form of spina bifida occulta. Conclusion. Our study indicates the need for routine echocardiography in all patients with congenital hypothyroidism.

  2. The Relationship between Drug-and Chemical-exposure and Birth Defects during Pregnancy

    Institute of Scientific and Technical Information of China (English)

    沈启芳; 张忠恕; 方可娟; 丁亦诺; 顾江; 王仁礼; 杨跃英; 李海放; 蒋秀蓉; 薛寿征

    1994-01-01

    A case-control study was conductedin 36 hospitals of the urban and suburban areas of Shanghai about the relationships between birth defects and drug use and chemieal exposures during pregnancy in the period of July 1987-December 1990. The case group was composed of 1.609 subjects, and the control group 3,218 cases. On statistical analysis, it was found that a correlation existed between birth defects and the intake of APC and diazepam, and the exposure to pesticides, organic soh, ents, benzene, synthetic resin and physical factors (noises) on the part of the mother, and the exposure to harmful chemicals and physical factors and the smoking of 20 or more cigarettes a day on the part of the father. It is also found that the familial hereditary history of the parents and muhigravidio,, malnutrition, common colds, hepatitis and diarrhea during pregnancy may also be related to the birth defects.

  3. [Interconnection between assisted reproductive technologies, pregnancy complications and risk of birth defects].

    Science.gov (United States)

    Grabar', V V

    2014-02-01

    The aim of the article was to investigate the relationship between pregnancy complications, infertility and assisted reproductive technologies (ART). The study was conducted on 1331 couples with complicated reproductive history. It is found that miscarriage and other complications of pregnancy depend rather on the etiopathogenesis of infertility than on the technique of ART. The highest frequency of complications of pregnancy was diagnosed in women with endocrine disorders. In case of congenital malformations in the fetus the frequency of birth defects was 3.6% after in vitro fertilization (IVF) and 1.8% in case of spontaneous pregnancy. It was found an increased risk of birth defects in singleton boys conceived by IVF.

  4. Birth defects in newborns and stillborns: an example of the Brazilian reality

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    Fett-Conte Agnes

    2011-09-01

    Full Text Available Abstract Background This study constitutes a clinical and genetic study of all newborn and stillborn infants with birth defects seen in a period of one year in a medical school hospital located in Brazil. The aims of this study were to estimate the incidence, causes and consequences of the defects. Methods For all infants we carried out physical assessment, photographic records, analysis of medical records and collection of additional information with the family, besides the karyotypic analysis or molecular tests in indicated cases. Result The incidence of birth defects was 2.8%. Among them, the etiology was identified in 73.6% (ci95%: 64.4-81.6%. Etiology involving the participation of genetic factors single or associated with environmental factors was more frequent 94.5%, ci95%: 88.5-98.0% than those caused exclusively by environmental factors (alcohol in and gestational diabetes mellitus. The conclusive or presumed diagnosis was possible in 85% of the cases. Among them, the isolated congenital heart disease (9.5% and Down syndrome (9.5% were the most common, followed by gastroschisis (8.4%, neural tube defects (7.4% and clubfoot (5.3%. Maternal age, parental consanguinity, exposure to teratogenic agents and family susceptibility were some of the identified risk factors. The most common observed consequences were prolonged hospital stays and death. Conclusions The current incidence of birth defects among newborns and stillbirths of in our population is similar to those obtained by other studies performed in Brazil and in other underdeveloped countries. Birth defects are one of the major causes leading to lost years of potential life. The study of birth defects in underdeveloped countries should continue. The identification of incidence, risk factors and consequences are essential for planning preventive measures and effective treatments.

  5. Sirenomelia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research, and Literature Review

    Science.gov (United States)

    ORIOLI, IÊDA M.; AMAR, EMMANUELLE; ARTEAGA-VAZQUEZ, JAZMIN; BAKKER, MARIAN K.; BIANCA, SEBASTIANO; BOTTO, LORENZO D.; CLEMENTI, MAURIZIO; CORREA, ADOLFO; CSAKY-SZUNYOGH, MELINDA; LEONCINI, EMANUELE; LI, ZHU; LÓPEZ-CAMELO, JORGE S.; LOWRY, R. BRIAN; MARENGO, LISA; MARTÍNEZ-FRÍAS, MARÍA-LUISA; MASTROIACOVO, PIERPAOLO; MORGAN, MARGERY; PIERINI, ANNA; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SZABOVA, ELENA; CASTILLA, EDUARDO E.

    2015-01-01

    Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance system members of the International Clearinghouse for Birth Defects Surveillance and Research, and were reported according to a single pre-established protocol. Cases were clinically evaluated locally and reviewed centrally. A total of 249 cases with sirenomelia were identified among 25,290,172 births, for a prevalence of 0.98 per 100,000, with higher prevalence in the Mexican registry. An increase of sirenomelia prevalence with maternal age less than 20 years was statistically significant. The proportion of twinning was 9%, higher than the 1% expected. Sex was ambiguous in 47% of cases, and no different from expectation in the rest. The proportion of cases born alive, premature, and weighting less than 2,500 g were 47%, 71.2%, and 88.2%, respectively. Half of the cases with sirenomelia also presented with genital, large bowel, and urinary defects. About 10–15% of the cases had lower spinal column defects, single or anomalous umbilical artery, upper limb, cardiac, and central nervous system defects. There was a greater than expected association of sirenomelia with other very rare defects such as bladder exstrophy, cyclopia/holoprosencephaly, and acardia-acephalus. The application of the new biological network analysis approach, including molecular results, to these associated very rare diseases is suggested for future studies. PMID:22002878

  6. Birth defects in perinatal infants in areas contiguous to Hongyanhe Nuclear Power Plant before its normal operation

    International Nuclear Information System (INIS)

    Objective: To understand the status of birth defects among the perinatal infants in the areas contiguous to Hongyanhe nuclear power plant before its normal operation, so as to provide background information for the evaluation of the impact of nuclear power plant on birth defects. Methods: From 1 October 1995 to 30 September 2009 the midwifery units at second class and above of Wafangdian City were asked to be in charge of recording the birth defects among the perinatal infants born during this period within the range of 50 km around the Hongyanhe nuclear power plant. Results: The total number of birth defects was 697, and the maternal number Was 83779. The average defect rate Was 83.20/104. There were significant differences in the birth defect rate among different years (χ2=39.54, P<0.05), however, without linear trend therein,and among the survey areas (χ2=15.36, P<0.05) as well. The top five birth defects were congenital heart disease (148 cases), cleft lip with cleft palate (67 cases), congenital hydrocephalus (63 cases), and spina bifida (37 cases) and cleft lip (36 cases). Conclusions: The birth defect rate within the range of 50 km around the Hongyanhe nuclear power plant is lower than that of the region of Liaoning Province and the national rate of birth defects. (authors)

  7. Diabetes and Obesity-Related Genes and the Risk of Neural Tube Defects in the National Birth Defects Prevention Study

    OpenAIRE

    Lupo, Philip J.; Canfield, Mark A.; Chapa, Claudia; Lu, Wei; Agopian, A.J.; Mitchell, Laura E; Shaw, Gary M.; Waller, D. Kim; Olshan, Andrew F.; Finnell, Richard H.; Zhu, Huiping

    2012-01-01

    Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study during 1999–2007. Log-linear models were used to evaluate maternal and...

  8. Low Birth Weight and Risk of Progression to End Stage Renal Disease in IgA Nephropathy-A Retrospective Registry-Based Cohort Study.

    Directory of Open Access Journals (Sweden)

    Paschal Ruggajo

    Full Text Available Low Birth Weight (LBW is a surrogate for fetal undernutrition and is associated with impaired nephron development in utero. In this study, we investigate whether having been born LBW and/or small for gestational age (SGA predict progression to ESRD in IgA nephropathy (IgAN patients.Retrospective registry-based cohort study.The Medical Birth Registry has recorded all births since 1967 and the Norwegian Renal Registry has recorded all patients with ESRD since 1980. Based on data from the Norwegian Kidney Biopsy Registry we included all patients diagnosed with IgAN in Norway from 1988-2013. These registries were linked and we analysed risk of progression to ESRD associated with LBW (defined as birth weight less than the 10th percentile and/or SGA (defined as birth weight less than the 10th percentile for gestational week by Cox regression statistics.We included 471 patients, of whom 74 developed ESRD. As compared to patients without LBW, patients with LBW had a hazard ratio (HR of 2.0 (95% confidence interval 1.1-3.7 for the total cohort, 2.2 (1.1-4.4 for males and 1.3 (0.30-5.8 for females. Corresponding HRs for SGA were 2.2 (1.1-4.2, 2.7 (1.4-5.5 and 0.8 (0.10-5.9. Further analyses showed that as compared to patients with neither LBW nor SGA, patients with either SGA or LBW did not have significantly increased risks (HRs of 1.3-1.4 but patients who were both LBW and SGA had an increased risk (HR 3.2 (1.5-6.8.Mean duration of follow-up only 10 years and maximum age only 46 years.Among IgAN patients, LBW and/or SGA was associated with increased risk for progression to ESRD, the association was stronger in males.

  9. Pharmacogenetics of drug-induced birth defects : the role of polymorphisms of placental transporter proteins

    NARCIS (Netherlands)

    Daud, Aizati N. A.; Bergman, Jorieke E. H.; Bakker, Marian K.; Wang, Hao; de Walle, Hermien E. K.; Plosch, Torsten; Wilffert, Bob

    2014-01-01

    One of the ongoing issues in perinatal medicine is the risk of birth defects associated with maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the exposition of the fetus to the drug. Transporter proteins are known to be involved in the pharmacokinetics of dru

  10. Timing of Zika Infection in Pregnancy May Be Key to Birth Defect Risk

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_159383.html Timing of Zika Infection in Pregnancy May Be Key to Birth Defect Risk Colombian ... federal policy. More Health News on: Infections and Pregnancy Zika Virus Recent Health News Related MedlinePlus Health Topics ...

  11. H1N1 'Swine Flu' Vaccine Unlikely to Raise Birth Defect Risk

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_161034.html H1N1 'Swine Flu' Vaccine Unlikely to Raise Birth Defect ... Swedish researchers report that the vaccine against the H1N1 "swine flu" strain of influenza doesn't seem ...

  12. Effect of consanguinity on birth defects in Saudi women; results from a nested case-control study

    DEFF Research Database (Denmark)

    Majeed-Saidan, Muhammad Ali; Ammari, Amer N; AlHashem, Amal M;

    2015-01-01

    BACKGROUND: The role of consanguinity in the etiology of structural birth defects outside of chromosomal and inherited disorders has always been debated. We studied the independent role of consanguinity on birth defects in Saudi women with a high prevalence of consanguineous marriages. METHODS: T...

  13. Correlation Between Birth Defects and Dietary Nutrition Status in a High Incidence Area of China1

    Institute of Scientific and Technical Information of China (English)

    BAO-YUAN ZHANG; QING-SHAN ZHANG; JIN ZHAO; YU-FU QIN; XIU-FENG YANG; GONG CHEN; JU-FEN LIU; XIN-MING SONG; XIAO-YING ZHENG; TING ZHANG; LIANG-MING LIN; FANG WANG; RUO-LEI XIN; XUE GU; YU-NA HE; DONG-MEI YU; PEI-ZHEN LI

    2008-01-01

    Objective To investigate the association between birth defects and dietary nutrient intake in a high risk area of China.Methods A dietary survey was performed and serum folic acid was measured in women whose pregnancy was affected by neural tube defects(NTDs)or unaffected by any birth defects(BDs)in Zhongyang and Jiaokou Counties in Shanxi Province of China.Results The local average censureption of foods including dark green vegetables,fluits,fat and meat,and nutrient intake(e.g.energy,protein,retinol,riboflavin,vitamin E,and selenium)were lower than the national average level.In women of childbearing age,these regions,the intake of nutrients was much lower than the recommended nutrient intake(9%-77%)The case-centrel dietary nutrition smdv of women whose pregnancy was affected bv BDs(including MTDs and congenital heart defects)demonstrated that,in early pregnancy,adequate nutrition(I.e.eating meat,fresh vegetables,fruit more than once a week)was a protective factor,while eating germinated potatoes was a risk factor.The geometrical mean(p5-p95)of serum folic acid in women with NTD birth defects was 9.6 nmol/L(3.6,23.03),which was significantly lower than that in normal women(14.03 nmol/L). Conclusion Wemen of childbearing age in the two counties of Shanxi Province,Chim,have a marked insufficient intake of some nutrients,especially folic acid,zinc,vitamins A and B12.This nutrient deficiency may be an important risk factor for the high prevalence of birth defects in these regions.Therefore,adequate dietary nutrition in early pregnancy can prevent BDs.

  14. Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile.

    Science.gov (United States)

    López-Camelo, Jorge S; Orioli, Iêda M; da Graça Dutra, Maria; Nazer-Herrera, Julio; Rivera, Nelson; Ojeda, María Elena; Canessa, Aurora; Wettig, Elisabeth; Fontannaz, Ana María; Mellado, Cecília; Castilla, Eduardo E

    2005-06-01

    To verify whether the decreasing neural tube defects birth prevalence rates in Chile are due to folic acid fortification or to pre-existing decreasing trends, we performed a population survey using a network of Estudio Colaborativo Latino Americano de Malformaciones Congenitas (ECLAMC, Latin American Collaborative Study of Congenital Malformations) maternity hospitals in Chile, between the years 1982 and 2002. Within each maternity hospital, birth prevalence rates of spina bifida and anencephaly were calculated from two pre-fortification periods (1982-1989 and 1990-2000), and from one fortified period (2001-2002). There was no historical trend for spina bifida birth prevalence rates before folic acid fortification, and there was a 51% (minimum 27%, maximum 66%) decrease in the birth prevalence rates of this anomaly in the fortified period. The relative risks of spina bifida were homogeneous among hospitals in the two period comparisons. There was no historical trend for the birth prevalence of anencephaly comparing the two pre-fortified periods, but the relative risks were heterogeneous among hospitals in this comparison. There was a 42% (minimum 10%, maximum 63%) decrease in the birth prevalence rate of anencephaly in the fortified period as compared with the immediately pre-fortified period, with homogeneous relative risks among hospitals. Within the methodological constraints of this study we conclude that the birth prevalence rates for both spina bifida and anencephaly decreased as a result of folic acid fortification, without interference of decreasing secular trends.

  15. Postmarketing analysis of medicines: methodology and value of the spanish case-control study and surveillance system in preventing birth defects.

    Science.gov (United States)

    Martínez-Frías, María Luisa

    2007-01-01

    There are many surveillance systems of congenital defects all over the world; several of them have developed specific approaches to generate and test selected hypotheses regarding human teratogens. However, to the best of our knowledge, none of them have a permanent and systematised programme for the study of the risk and safety of drugs. The aim of this article is to describe the research programme on the potential effects of drugs in pregnancy followed by the Spanish Collaborative Study of Congenital Malformations (ECEMC), which is a permanent ongoing case-control study and surveillance system. The programme to analyse drugs includes a continuous and systematic study on the potential effects of medicines used during pregnancy. This programme has several characteristics that make it different from other current systems: (i) the collection of numerous datapoints (up to 312 per infant) in a case-control design; (ii) the use of a versatile and specific coding of birth defects; (iii) a specific programme for the continuous analysis of the potential effects of each type of drugs used during pregnancy that has been developed specifically for the ECEMC methodology, including its dysmorphological coding system. The description of the ECEMC's approach to surveillance of the effects of drug use during pregnancy may help researches in this area, particularly those using data from birth defects registries. PMID:17408307

  16. Pharmacogenetics of drug-induced birth defects: the role of polymorphisms of placental transporter proteins.

    Science.gov (United States)

    Daud, Aizati N A; Bergman, Jorieke E H; Bakker, Marian K; Wang, Hao; de Walle, Hermien E K; Plösch, Torsten; Wilffert, Bob

    2014-05-01

    One of the ongoing issues in perinatal medicine is the risk of birth defects associated with maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the exposition of the fetus to the drug. Transporter proteins are known to be involved in the pharmacokinetics of drugs and have an effect on drug level and fetal drug exposure. This condition may subsequently alter the risk of teratogenicity, which occurs in a dose-dependent manner. This review focuses on the clinically important polymorphisms of transporter proteins and their effects on the mRNA and protein expression in placental tissue. We also propose a novel approach on how the different genotypes of the polymorphism can be translated into phenotypes to facilitate genetic association studies. The last section looks into the recent studies exploring the association between P-glycoprotein polymorphisms and the risk of fetal birth defects associated with medication use during pregnancy.

  17. Construction of HMI Network System for Individualized Maternity Intervention Service against Birth Defects in Community

    Institute of Scientific and Technical Information of China (English)

    Xu-huai HU

    2007-01-01

    The paper expounds the community maternity service system against birth defects,from the viewpoint of individualized service in family planning. We have utilized modern information technology to develop health management information (HMI) network with individualized maternity, and to establish the community service system for intervention of birth defects. The service system applied the concept of modern health management information to implementing informational management for screening,treatment, following up, outcome monitoring, so as to provide a base for promotion of health, diagnosis, treatment as well as scientific research, with the prenatal screening of Down's syndrome as a model. The introduction to informational network during the processes of service has been carried out with regards to its composition, function and application, while introducing the effects of computerized case record individualized in prevention, management and research of Down's syndrome.

  18. A Study of Handling Cytotoxic Drugs and Risk of Birth Defects in Offspring of Female Veterinarians

    Directory of Open Access Journals (Sweden)

    Adeleh Shirangi

    2014-06-01

    Full Text Available We examined the association of occupational exposure to handling cytotoxic drugs at work with risk of birth defects among a cohort of female veterinarians. This study is a follow up survey of 321 female participants (633 pregnancies who participated in the Health Risks of Australian Veterinarian project. Data on pregnancies and exposure during each pregnancy was obtained by self-administered mailed questionnaire. Female veterinarians handling cytotoxic drugs during their pregnancy had a two-fold increased risk of birth defects in their offspring (RR = 2.08, 95% CI (1.05–4.15. Results were consistent in subgroup analysis of those who graduated during the period of 1961 to 1980 (RR = 5.04, 95% CI (1.81, 14.03 and in those working specifically in small and large animal practice. There was no increased risk in the subgroup that graduated after 1980. Women with unplanned pregnancies were more likely to handle cytotoxic drugs on a daily basis (RR = 1.86, 95% CI, 1.00–3.48 and had a higher increased risk of birth defects than those who planned their pregnancies in recent graduates and in those who worked specifically in small animal practice (RR = 2.53, 95% CI, 1.18–5.42. This study suggests that the adverse effects of handling cytotoxic drugs in pregnant women may include an increased risk of birth defects. Pregnancy intention status is an important health behavior and should be considered in prenatal programs.

  19. Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation with Environmental Factors

    Directory of Open Access Journals (Sweden)

    Raneem Al Shawwa

    2012-05-01

    Full Text Available This is the first report of registration at birth, and of incidence of major structural birth defects (BD obtained in Gaza at Al Shifa Hospital, where 28% of total births in Gaza Strip occur. Doctors registered 4,027 deliveries, with a protocol comprehensive of clinical, demographic, kin and environmental questions. Prevalence of BD is 14/1,000, without association with intermarriage or gender of the child. Prevalence of late miscarriages and still births are respectively 23.3/1,000 and 7.4/1,000, and of premature births 19.6/1,000. Couples with a BD child have about 10 times higher frequency of recurrence of a BD in their progeny than those with normal children, but none of their 694 siblings and only 10/1,000 of their 1,423 progeny had BD, similar to the frequency in general population. These data suggest occurrence of novel genetic and epigenetic events in determination of BD. Children with BD were born with higher frequency (p < 0 001 in families where one or both parents were under “white phosphorus” attack, that in the general population. Bombing of the family home and removal of the rubble were also frequently reported by couples with BD occurrence. These data suggests a causative/favoring role of acute exposure of parents to the weapons-associated contaminants, and/or of their chronic exposure from their persistence in the environment on the embryonic development of their children.

  20. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands.

    NARCIS (Netherlands)

    Beijnum, I.M. van; Kapusta, L.; Bakker, M.K.; Heijer, M. den; Blom, H.J.; Walle, H.E. de

    2010-01-01

    AIMS: To investigate the potentially protective of periconceptional folic acid use on the risk of congenital heart defects (CHDs) relative to other non-folate related malformations. METHODS AND RESULTS: We analysed data from a large regional register of birth defects (EUROCAT-Northern Netherlands),

  1. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects : a registry-based case-control study in the northern Netherlands

    NARCIS (Netherlands)

    van Beynum, Ingrid M.; Kapusta, Livia; Bakker, Marian K.; den Heijer, Martin; Blom, Henk J.; de Walle, Hermien E. K.

    2010-01-01

    To investigate the potentially protective of periconceptional folic acid use on the risk of congenital heart defects (CHDs) relative to other non-folate related malformations. We analysed data from a large regional register of birth defects (EUROCAT-Northern Netherlands), over a 10 year period (1996

  2. Birth prevalence for congenital limb defects in the northern Netherlands : a 30-year population-based study

    NARCIS (Netherlands)

    Vasluian, Ecaterina; van der Sluis, Corry K; van Essen, Anthonie J; Bergman, Jorieke E H; Dijkstra, Pieter U; Reinders-Messelink, Heleen A; de Walle, Hermien E K

    2013-01-01

    Background: Reported birth prevalences of congenital limb defects (CLD) vary between countries: from 13/10,000 in Finland for the period 1964-1977 to 30.4/10,000 births in Scotland from 1964-1968. Epidemiological studies permit the timely detection of trends in CLD and of associations with other bir

  3. Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Komal Preet Allagh

    Full Text Available In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and orofacial clefts in India have reported inconsistent results. Therefore, we conducted a systematic review of observational studies to document the birth prevalence of neural tube defects and orofacial clefts.A comprehensive literature search for observational studies was conducted in MEDLINE and EMBASE databases using key MeSH terms (neural tube defects OR cleft lip OR cleft palate AND Prevalence AND India. Two reviewers independently reviewed the retrieved studies, and studies satisfying the eligibility were included. The quality of included studies was assessed using selected criteria from STROBE statement.The overall pooled birth prevalence (random effect of neural tube defects in India is 4.5 per 1000 total births (95% CI 4.2 to 4.9. The overall pooled birth prevalence (random effect of orofacial clefts is 1.3 per 1000 total births (95% CI 1.1 to 1.5. Subgroup analyses were performed by region, time period, consanguinity, and gender of newborn.The overall prevalence of neural tube defects from India is high compared to other regions of the world, while that of orofacial clefts is similar to other countries. The majority of studies included in the review were hospital based. The quality of these studies ranged from low to moderate. Further well-designed, high quality community-based observational studies are needed to accurately estimate the burden of neural tube defects and orofacial clefts in India.

  4. Assessment of student pharmacists' knowledge concerning folic acid and prevention of birth defects demonstrates a need for further education.

    Science.gov (United States)

    Lynch, Sean M

    2002-03-01

    Adequate periconceptional consumption of folic acid can prevent neural tube birth defects, and all women capable of becoming pregnant are recommended to consume 400 microg/d. Most women, however, are unaware of this recommendation and do not consume adequate amounts of folic acid. It is important, therefore, that healthcare professionals, such as pharmacists, be capable of educating women regarding folic acid. The aim of this study was to assess knowledge regarding prevention of birth defects by folic acid among student (future) pharmacists in the final year of a professional degree program. Over a 3-y period (1998-2000), students (n = 98) enrolled in a PharmD program completed a survey consisting of five multiple-choice questions concerning folic acid and birth defects. Almost all students (93.9%) correctly identified folic acid as preventing birth defects. Of these students, many also knew that supplementation should begin before pregnancy (73.9%). Fewer, however, were able to correctly identify either the recommended level of intake (55.4%) or good sources of folic acid (57.6-65.2%). These results show that although student (future) pharmacists are aware of folic acid's ability to prevent birth defects, many lack the specific knowledge needed to effectively counsel women in future clinical practice.

  5. Birth defects data for 8 California counties by county, maternal age, maternal race/ethnicity, and infant gender for the years 2000-2006.

    Data.gov (United States)

    California Environmental Health Tracking Program — This dataset contains counts, rates, and confidence intervals of 12 selected birth defects among live births during 2000-2006 within eight California counties:...

  6. Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects

    Science.gov (United States)

    Weyer, Peter J.; Brender, Jean D.; Romitti, Paul A.; Kantamneni, Jiji R.; Crawford, David; Sharkey, Joseph R.; Shinde, Mayura; Horel, Scott A.; Vuong, Ann M.; Langlois, Peter H.

    2016-01-01

    Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997–2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers’ overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS. PMID:25473985

  7. The effects of periconceptional risk factor exposure and micronutrient supplementation on birth defects in Shaanxi Province in Western China.

    Directory of Open Access Journals (Sweden)

    Wenfang Yang

    Full Text Available OBJECTIVES: 1 To understand the current prevalence and main types of birth defects, 2 assess the periconceptional exposure of factors associated with birth defects in Shaanxi Province, and 3 provide scientific evidence for local governments to formulate services for the primary prevention of birth defects. METHODS: We sampled 16,541 households from 128 townships in 16 counties/districts in Shaanxi province using a multi-stage random sampling method. Among them, 10,544 women who had live born or stillborn infants with gestational age ≥ 28 weeks between 2008 and 2009 were interviewed using a structured questionnaire designed to collect information about periconceptional risk factor exposure, health care service utilization, and micronutrient supplements. Logistic regression was performed to assess the risk factors associated with birth defects and adjustments were made for imbalanced social-demographic characteristics between case and control groups. RESULTS: The prevalence of congenital birth defect in Shaanxi province was 14.3/1000 births. The environment risk factors associated with birth defects include unhealthy lifestyle (Alcohol, odds ratio (OR: 3.60, 95% confidence interval (CI 1.64-7.91; Smoking, OR: 1.32, 95% CI: 0.99-1.75; Drink strong tea, OR: 1.81, 95% CI: 1.27-2.59, exposure to heavy pollution (OR: 1.53, 95% CI: 1.01-2.30, maternal diseases (OR: 1.77, 95% CI: 1.35-2.33, drug use (OR: 2.11, 95% CI: 1.51-2.95, maternal chemical pesticide exposure (OR: 2.30, 95% CI: 1.16-4.57, and adverse pregnancy history (OR: 10.10, 95% CI: 7.55-13.53. Periconceptional folic acid or multiple micronutrients including folic acid supplementation, was associated with a reduced rate of birth defects (OR: 0.54, 95% CI: 0.29-0.998. CONCLUSIONS: Health care service utilization, unhealthy lifestyle factors, and environment risk factors seem to be associated with birth defects in Shaanxi province. Governmental agencies should focus on effective primary

  8. Diabetes and Obesity-Related Genes and the Risk of Neural Tube Defects in the National Birth Defects Prevention Study

    Science.gov (United States)

    Lupo, Philip J.; Canfield, Mark A.; Chapa, Claudia; Lu, Wei; Agopian, A. J.; Mitchell, Laura E.; Shaw, Gary M.; Waller, D. Kim; Olshan, Andrew F.; Finnell, Richard H.; Zhu, Huiping

    2012-01-01

    Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study during 1999–2007. Log-linear models were used to evaluate maternal and offspring genetic effects. After application of the false discovery rate, there were 5 significant maternal genetic effects. The less common alleles at the 4 FTO single nucleotide polymorphisms showed a reduction of NTD risk (for rs1421085, relative risk (RR) = 0.73 (95% confidence interval (CI): 0.62, 0.87); for rs8050136, RR = 0.79 (95% CI: 0.67, 0.93); for rs9939609, RR = 0.79 (95% CI: 0.67, 0.94); and for rs17187449, RR = 0.80 (95% CI: 0.68, 0.95)). Additionally, maternal LEP rs2071045 (RR = 1.31, 95% CI: 1.08, 1.60) and offspring UCP2 rs660339 (RR = 1.32, 95% CI: 1.06, 1.64) were associated with NTD risk. Furthermore, the maternal genotype for TCF7L2 rs3814573 suggested an increased NTD risk among obese women. These findings indicate that maternal genetic variants associated with glucose homeostasis may modify the risk of having an NTD-affected pregnancy. PMID:23132673

  9. Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.

    Science.gov (United States)

    Lupo, Philip J; Canfield, Mark A; Chapa, Claudia; Lu, Wei; Agopian, A J; Mitchell, Laura E; Shaw, Gary M; Waller, D Kim; Olshan, Andrew F; Finnell, Richard H; Zhu, Huiping

    2012-12-15

    Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study during 1999-2007. Log-linear models were used to evaluate maternal and offspring genetic effects. After application of the false discovery rate, there were 5 significant maternal genetic effects. The less common alleles at the 4 FTO single nucleotide polymorphisms showed a reduction of NTD risk (for rs1421085, relative risk (RR) = 0.73 (95% confidence interval (CI): 0.62, 0.87); for rs8050136, RR = 0.79 (95% CI: 0.67, 0.93); for rs9939609, RR = 0.79 (95% CI: 0.67, 0.94); and for rs17187449, RR = 0.80 (95% CI: 0.68, 0.95)). Additionally, maternal LEP rs2071045 (RR = 1.31, 95% CI: 1.08, 1.60) and offspring UCP2 rs660339 (RR = 1.32, 95% CI: 1.06, 1.64) were associated with NTD risk. Furthermore, the maternal genotype for TCF7L2 rs3814573 suggested an increased NTD risk among obese women. These findings indicate that maternal genetic variants associated with glucose homeostasis may modify the risk of having an NTD-affected pregnancy. PMID:23132673

  10. Genomic Imbalances in Neonates With Birth Defects: High Detection Rates by Using Chromosomal Microarray Analysis

    Science.gov (United States)

    Lu, Xin-Yan; Phung, Mai T.; Shaw, Chad A.; Pham, Kim; Neil, Sarah E.; Patel, Ankita; Sahoo, Trilochan; Bacino, Carlos A.; Stankiewicz, Pawel; Lee Kang, Sung-Hae; Lalani, Seema; Chinault, A. Craig; Lupski, James R.; Cheung, Sau W.; Beaudet, Arthur L.

    2009-01-01

    OBJECTIVES Our aim was to determine the frequency of genomic imbalances in neonates with birth defects by using targeted array-based comparative genomic hybridization, also known as chromosomal microarray analysis. METHODS Between March 2006 and September 2007, 638 neonates with various birth defects were referred for chromosomal microarray analysis. Three consecutive chromosomal microarray analysis versions were used: bacterial artificial chromosome-based versions V5 and V6 and bacterial artificial chromosome emulated oligonucleotide-based version V6 Oligo. Each version had targeted but increasingly extensive genomic coverage and interrogated >150 disease loci with enhanced coverage in genomic rearrangement-prone pericentromeric and subtelomeric regions. RESULTS Overall, 109 (17.1%) patients were identified with clinically significant abnormalities with detection rates of 13.7%, 16.6%, and 19.9% on V5, V6, and V6 Oligo, respectively. The majority of these abnormalities would not be defined by using karyotype analysis. The clinically significant detection rates by use of chromosomal microarray analysis for various clinical indications were 66.7% for “possible chromosomal abnormality” ± “others” (other clinical indications), 33.3% for ambiguous genitalia ± others, 27.1% for dysmorphic features + multiple congenital anomalies ± others, 24.6% for dysmorphic features ± others, 21.8% for congenital heart disease ± others, 17.9% for multiple congenital anomalies ± others, and 9.5% for the patients referred for others that were different from the groups defined. In all, 16 (2.5%) patients had chromosomal aneuploidies, and 81 (12.7%) patients had segmental aneusomies including common microdeletion or microduplication syndromes and other genomic disorders. Chromosomal mosaicism was found in 12 (1.9%) neonates. CONCLUSIONS Chromosomal microarray analysis is a valuable clinical diagnostic tool that allows precise and rapid identification of genomic imbalances

  11. Spontaneous abortions and birth defects related to tap and bottled water use, San Jose, California, 1980-1985.

    Science.gov (United States)

    Wrensch, M; Swan, S H; Lipscomb, J; Epstein, D M; Neutra, R R; Fenster, L

    1992-03-01

    We recently studied pregnancies occurring during 1980-1985 in four study areas in Santa Clara County, California. Two of the areas were exposed to solvent-contaminated drinking water during 1980 and 1981, and two were unexposed. There was an overall excess of spontaneous abortions among women who reported any tapwater consumption during the first trimester of pregnancy compared with those who reported no tapwater consumption [odds ratio (OR) = 4.0; 95% confidence interval (CI) = 1.8-9.1)], regardless of exposure to the contaminated water. The odds ratio for spontaneous abortion for women reporting any vs no tapwater was 6.9 (95% CI = 2.7-17.7) after adjustment for numerous potential confounders using multiple logistic regression analyses. The elevated odds ratio of spontaneous abortion was seen among tapwater drinkers who used no filters or softener-type filters but not among women who reported use of active filters. Spontaneous abortion rates were reduced in women who reported any vs no bottled water consumption (OR = 0.26; 95% CI = 0.16-0.43). Among women who reported no tapwater consumption, no birth defects occurred among 263 live births; in comparison, among women who reported tapwater consumption, 4% of 908 live births had defects (P = 0.0001). We observed no relation between birth defects and bottled water use. PMID:1576232

  12. Spontaneous abortions and birth defects related to tap and bottled water use, San Jose, California, 1980-1985

    Energy Technology Data Exchange (ETDEWEB)

    Wrensch, M.; Swan, S.H.; Lipscomb, J.; Epstein, D.M.; Neutra, R.R.; Fenster, L. (Department of Epidemiology and Biostatistics, University of California, San Francisco (United States))

    1992-03-01

    We recently studied pregnancies occurring during 1980-1985 in four study areas in Santa Clara County, California. Two of the areas were exposed to solvent-contaminated drinking water during 1980 and 1981, and two were unexposed. There was an overall excess of spontaneous abortions among women who reported any tapwater consumption during the first trimester of pregnancy compared with those who reported no tapwater consumption (odds ratio (OR) = 4.0; 95% confidence interval (CI) = 1.8-9.1), regardless of exposure to the contaminated water. The odds ratio for spontaneous abortion for women reporting any vs no tapwater was 6.9 (95% CI = 2.7-17.7) after adjustment for numerous potential confounders using multiple logistic regression analyses. The elevated odds ratio of spontaneous abortion was seen among tapwater drinkers who used no filters or softener-type filters but not among women who reported use of active filters. Spontaneous abortion rates were reduced in women who reported any vs no bottled water consumption (OR = 0.26; 95% CI = 0.16-0.43). Among women who reported no tapwater consumption, no birth defects occurred among 263 live births; in comparison, among women who reported tapwater consumption, 4% of 908 live births had defects (P = 0.0001). We observed no relation between birth defects and bottled water use.

  13. The Danish Cerebral Palsy Registry. A registry on a specific impairment

    DEFF Research Database (Denmark)

    Uldall, P; Michelsen, S I; Topp, M;

    2001-01-01

    Cerebral palsy (CP) is the commonest disabling impairment in childhood, with a prevalence of 2-3 per 1000 live births. The Danish Cerebral Palsy Registry is a research registry that contains cases of CP from birth year 1925 and has estimated the birth prevalence since 1950. Data on children with CP...

  14. The Norwegian Twin Registry.

    Science.gov (United States)

    Nilsen, Thomas S; Brandt, Ingunn; Magnus, Per; Harris, Jennifer R

    2012-12-01

    Norway has a long-standing tradition in twin research, but the data collected in several population-based twin studies were not coordinated centrally or easily accessible to the scientific community. In 2009, the Norwegian Twin Registry was established at the Norwegian Institute of Public Health (NIPH) in Oslo with the purpose of creating a single research resource for Norwegian twin data. As of today, the Norwegian Twin Registry contains 47,989 twins covering birth years 1895-1960 and 1967-1979; 31,440 of these twins consented to participate in health-related research. In addition, DNA from approximately 4,800 of the twins is banked at the NIPH biobank and new studies are continually adding new data to the registry. The value of the Norwegian twin data is greatly enhanced by the linkage opportunities offered by Norway's many nationwide registries, spanning a broad array of medical, demographic, and socioeconomic information.

  15. Cyclopia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research

    Science.gov (United States)

    Orioli, Iêda M.; Amar, Emmanuelle; Bakker, Marian K.; Bermejo-Sánchez, Eva; Bianchi, Fabrizio; Canfield, Mark A.; Clementi, Maurizio; Correa, Adolfo; Csáky-Szunyogh, Melinda; Feldkamp, Marcia L.; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Morgan, Margery; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Castilla, Eduardo E.

    2015-01-01

    Cyclopia is characterized by the presence of a single eye, with varying degrees of doubling of the intrinsic ocular structures, located in the middle of the face. It is the severest facial expression of the holoprosencephaly (HPE) spectrum. This study describes the prevalence, associated malformations, and maternal characteristics among cases with cyclopia. Data originated in 20 Clearinghouse (ICBDSR) affiliated birth defect surveillance systems, reported according to a single pre-established protocol. A total of 257 infants with cyclopia were identified. Overall prevalence was 1 in 100,000 births (95%CI: 0.89–1.14), with only one program being out of range. Across sites, there was no correlation between cyclopia prevalence and number of births (r = 0.08; P=0.75) or proportion of elective termination of pregnancy (r= −0.01; P=0.97). The higher prevalence of cyclopia among older mothers (older than 34) was not statistically significant. The majority of cases were liveborn (122/200; 61%) and females predominated (male/total: 42%). A substantial proportion of cyclopias (31%) were caused by chromosomal anomalies, mainly trisomy 13. Another 31% of the cases of cyclopias were associated with defects not typically related to HPE, with more hydrocephalus, heterotaxia defects, neural tube defects, and preaxial reduction defects than the chromosomal group, suggesting the presence of ciliopathies or other unrecognized syndromes. Cyclopia is a very rare defect without much variability in prevalence by geographic location. The heterogeneous etiology with a high prevalence of chromosomal abnormalities, and female predominance in HPE, were confirmed, but no effect of increased maternal age or association with twinning was observed. PMID:22006661

  16. Nanomaterial Registry

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Nanomaterial Registry compiles data from multiple databases into a single resource. The goal of this resource is to establish a curated nanomaterial registry,...

  17. Impact of Maternal Country of Birth on Type-1-Diabetes Therapy and Outcome in 27,643 Children and Adolescents from the DPV Registry.

    Directory of Open Access Journals (Sweden)

    Nicole Scheuing

    Full Text Available To study the impact of maternal country of birth on type-1-diabetes (T1D therapy and outcome.27,643 T1D patients aged ≤20 years with documented maternal country of birth from the multicenter German/Austrian diabetes patient registry (DPV were analyzed. Patients were categorized based on their mother's origin: Germany/Austria (reference, Turkey, Southern Europe, and Eastern Europe. To compare BMI standard deviation score (BMI-SDS, diabetes therapy and outcome between groups, multivariable regression was applied with adjustments for age, sex and duration of diabetes. Based on observed marginal frequencies, adjusted estimates were calculated. Linear regression was used for continuous data, logistic regression for binary data and Poisson regression for count data. All statistical analyses were performed using SAS 9.4. Significance was set at a two-tailed p<0.05.83.3% of patients were offspring of native mothers. A Turkish, Southern or Eastern European background was documented in 2.4%, 1.7% and 4.3% of individuals. After demographic adjustment, patients with migration background had a higher mean BMI-SDS (Turkey, Southern Europe or Eastern Europe vs. Germany/Austria: 0.58±0.03, 0.40±0.04, or 0.37±0.02 vs. 0.31±0.01; ±SE and a lower use of insulin pumps (26.8%, 27.9%, or 32.6% vs. 37.9% compared to offspring of native mothers. Mean HbA1c was worst in individuals of Turkish mothers (Turkey vs. Germany/Austria: 69.7±0.7 vs. 66.6±0.1 mmol/mol; ±SE. Patients of Eastern European descent had an increased rate of severe hypoglycemia (22.09±0.13 vs. 16.13±0.02 events per 100 patient-years and ketoacidosis was more prevalent in offspring of Turkish or Southern European mothers (7.50±0.10, or 7.13±0.11 vs. 6.54±0.02 events per 100 patient-years. Patients of Turkish descent were more often hospitalized (57.2±2.7 vs. 48.5±0.4 per 100 patient-years. All differences were significant.The differences in diabetes therapy and outcome among patients

  18. The experience of black parents/caretakers with the births and care of a child with profound congenital defects

    Directory of Open Access Journals (Sweden)

    M.S. Mabaso

    1990-09-01

    Full Text Available The reaction of Black families to the birth and care of a baby with profound congenital defects was researched using twenty case studies. It was found that the families went through stages of the grieving process, that they shifted from the Western/Christian viewpoint to the traditional viewpoint in their struggle to cope and that they find the existing services grossly inadequate.

  19. Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study

    OpenAIRE

    Huber, John C.; Brender, Jean D; Zheng, Qi; Sharkey, Joseph R; Vuong, Ann M; Shinde, Mayura U; Griesenbeck, John S; Suarez, Lucina; Langlois, Peter H.; Canfield, Mark A.; Romitti, Paul A.; Weyer, Peter J.

    2013-01-01

    Background Dietary intake of nitrates, nitrites, and nitrosamines can increase the endogenous formation of N-nitroso compounds in the stomach. Results from animal studies suggest that these compounds might be teratogenic. We examined the relationship between maternal dietary intake of nitrates, nitrites (including plant and animal sources as separate groups), and nitrosamines and several types of birth defects in offspring. Methods For this population-based case–control study, data from a 58-...

  20. Tritium releases from the Pickering Nuclear Generating Station and birth defects and infant mortality in nearby communities 1971-1988

    International Nuclear Information System (INIS)

    This study was commissioned to examine whether there were elevated rates of stillbirth, birth defects, or death in the first year of life between 1971 and 1988 among offspring of residents of communities within a 25-kilometre radius of the Pickering Nuclear Generating Station. The study was also to investigate whether there were any statistical associations between the monthly airborne or waterborne tritium emissions from the Pickering Nuclear Generating Station and the rates of these reproductive outcomes. Overall analysis did not support a hypothesis of increased rates of stillbirths, neonatal mortality or infant mortality near the Pickering Nuclear Generating Station, or a hypothesis of increased birth prevalence of birth defects for 21 of 22 diagnostic categories. The prevalence of Down Syndrome was elevated in both Pickering and Ajax; however, there was no consistent pattern between tritium release levels and Down Syndrome prevalence, chance could not be ruled out for the associations between Down Syndrome and tritium releases or ground-monitored concentrations, the association was detected in an analysis where multiple testing was done which may turn up significant associations by change, and maternal residence at birth and early in pregnancy needs to be verified. The association between Down Syndrome and low-level radiation remains indeterminate when existing evidence from epidemiological studies is summed. The estimated radiation exposure from the nuclear plant for residents of Pickering and Ajax is lower by a factor of 100 than the normal natural background radiation. Further study is recommended. (21 tabs., 29 figs., 5 maps, 37 refs.)

  1. Next generation sequencing in research and diagnostics of ocular birth defects.

    Science.gov (United States)

    Raca, Gordana; Jackson, Craig; Warman, Berta; Bair, Tom; Schimmenti, Lisa A

    2010-06-01

    Sequence capture enrichment (SCE) strategies and massively parallel next generation sequencing (NGS) are expected to increase the rate of gene discovery for genetically heterogeneous hereditary diseases, but at present, there are very few examples of successful application of these technologic advances in translational research and clinical testing. Our study assessed whether array based target enrichment followed by re-sequencing on the Roche Genome Sequencer FLX (GS FLX) system could be used for novel mutation identification in more than 1000 exons representing 100 candidate genes for ocular birth defects, and as a control, whether these methods could detect two known mutations in the PAX2 gene. We assayed two samples with heterozygous sequence changes in PAX2 that were previously identified by conventional Sanger sequencing. These changes were a c.527G>C (S176T) substitution and a single basepair deletion c.77delG. The nucleotide substitution c.527G>C was easily identified by NGS. A deletion of one base in a long polyG stretch (c.77delG) was not registered initially by the GS Reference Mapper, but was detected in repeated analysis using two different software packages. Different approaches were evaluated for distinguishing false positives (sequencing errors) and benign polymorphisms from potentially pathogenic sequence changes that require further follow-up. Although improvements will be necessary in accuracy, speed, ease of data analysis and cost, our study confirms that NGS can be used in research and diagnostic settings to screen for mutations in hundreds of loci in genetically heterogeneous human diseases. PMID:20359920

  2. The Brazilian Zika virus strain causes birth defects in experimental models.

    Science.gov (United States)

    Cugola, Fernanda R; Fernandes, Isabella R; Russo, Fabiele B; Freitas, Beatriz C; Dias, João L M; Guimarães, Katia P; Benazzato, Cecília; Almeida, Nathalia; Pignatari, Graciela C; Romero, Sarah; Polonio, Carolina M; Cunha, Isabela; Freitas, Carla L; Brandão, Wesley N; Rossato, Cristiano; Andrade, David G; Faria, Daniele de P; Garcez, Alexandre T; Buchpigel, Carlos A; Braconi, Carla T; Mendes, Erica; Sall, Amadou A; Zanotto, Paolo M de A; Peron, Jean Pierre S; Muotri, Alysson R; Beltrão-Braga, Patricia C B

    2016-05-11

    Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. However, in 2007, vectored by Aedes aegypti mosquitoes, ZIKV caused the first noteworthy epidemic on the Yap Island in Micronesia. Patients experienced fever, skin rash, arthralgia and conjunctivitis. From 2013 to 2015, the Asian lineage of the virus caused further massive outbreaks in New Caledonia and French Polynesia. In 2013, ZIKV reached Brazil, later spreading to other countries in South and Central America. In Brazil, the virus has been linked to congenital malformations, including microcephaly and other severe neurological diseases, such as Guillain-Barré syndrome. Despite clinical evidence, direct experimental proof showing that the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent. Here we demonstrate that ZIKV(BR) infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells, leading to an increase in cell death. We also report that the infection of human brain organoids results in a reduction of proliferative zones and disrupted cortical layers. These results indicate that ZIKV(BR) crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, and impairing neurodevelopment. Our data reinforce the growing body of evidence linking the ZIKV(BR) outbreak to the alarming number of cases of congenital brain malformations. Our model can be used to determine the efficiency of therapeutic approaches to counteracting the harmful impact of ZIKV(BR) in human neurodevelopment.

  3. Research Progress on Environment Factors Leading to Birth Defects%导致出生缺陷的环境因素研究进展

    Institute of Scientific and Technical Information of China (English)

    蔡晶

    2012-01-01

    Birth defects is the structural or functional abnormalities already existed before birth (which can be found in a lifetime years before or after birth) ,and its causes including genetic, environmental and both of joint action. Environmental factors have become threats to humanity even in the reproduction of the species. Nowadays .birth defects has become one of the hot topics. This review focuses on recent environmental factors on the impact of birth defects,and focus on the ultrasound and psychological factors associated with birth defects.%出生缺陷(birth defects)是指出生前已经存在(在出生前或出生后数年内可以发现)的结构或功能异常,其产生原因包括遗传、环境以及两者的共同作用.环境问题已经变成威胁人类生存甚至繁衍的一个重要问题.出生缺陷也已成为当今世界关注的热点课题之一.综述近年有关环境因素对出生缺陷影响的研究,并重点探讨超声波及心理因素与出生缺陷的相关性.

  4. Birth defects in Norway by levels of external and food-based exposure to radiation from Chernobyl

    Energy Technology Data Exchange (ETDEWEB)

    Lie, R.T.; Irgens, L.M.; Skjaerven, R.; Reitan, J.B.; Strand, P.; Strand, T. (Medical Birth Registry of Norway, University of Bergen (Norway))

    1992-08-15

    In Norway, external doses of radiation resulting from fallout from the Chernobyl nuclear accident were estimated from detailed measurements, including soil deposition patterns. Internal doses were estimated from measurements of radioactive cesium in meat and milk supplies. The doses were calculated as average monthly doses for each of 454 municipalities during 36 consecutive months after the accident in spring 1986. Prospectively collected data on all newborns listed in the Medical Birth Registry of Norway who were conceived in the period May 1983-April 1989 were used to assess possible dose-response relations between estimated external and food-based exposures and congenital malformations and some other conditions. A positive association was observed between total radiation dose (external plus food-based) and hydrocephaly, while a negative association was observed for Down's syndrome. However, an important conclusion of the study was that no associations were found for conditions previously reported to be associated with radiation, i.e., small head circumference, congenital cataracts, anencephaly, spina bifida, and low birth weight. Potential sources of bias, including exposure misclassification and incomplete ascertainment of cases, are discussed.

  5. Birth defects in Norway by levels of external and food-based exposure to radiation from Chernobyl

    International Nuclear Information System (INIS)

    In Norway, external doses of radiation resulting from fallout from the Chernobyl nuclear accident were estimated from detailed measurements, including soil deposition patterns. Internal doses were estimated from measurements of radioactive cesium in meat and milk supplies. The doses were calculated as average monthly doses for each of 454 municipalities during 36 consecutive months after the accident in spring 1986. Prospectively collected data on all newborns listed in the Medical Birth Registry of Norway who were conceived in the period May 1983-April 1989 were used to assess possible dose-response relations between estimated external and food-based exposures and congenital malformations and some other conditions. A positive association was observed between total radiation dose (external plus food-based) and hydrocephaly, while a negative association was observed for Down's syndrome. However, an important conclusion of the study was that no associations were found for conditions previously reported to be associated with radiation, i.e., small head circumference, congenital cataracts, anencephaly, spina bifida, and low birth weight. Potential sources of bias, including exposure misclassification and incomplete ascertainment of cases, are discussed

  6. 怀孕年龄与胎次对出生缺陷的影响分析%The Impact of Age of Pregnancy and Birth Order on Birth Defects

    Institute of Scientific and Technical Information of China (English)

    张帆; 李骅; 米红

    2015-01-01

    Based on the 5782 cases of patients from the Attached of Obstetrical and Gynecological Hospital of Zhejiang University , the paper analyzes the impacts of pregnant age and birth order on the fetal defect rate as well as impacts of the fetal defect on the population quality at the policy of two-children for all families. It is found that the pregnant age lower than 19 and older than 35 can cause the increase of fetal defect rate , while the birth order impact the birth defect rate in different ways , the higher the birth order is , for those mothers younger than 24 , the higher rate of birth defect and for the mothers aged 25-44 there is no increase of birth defect rate for their second and third child birth but with a relatively higher birth defects for their fourth child birth. It seems that the birth defect rate of second child have no negative impacts on population quality even after the permit of second child birth for all families in future.%本研究通过抽取浙江大学医学院附属妇产科医院某病区5782个病例(736例患病),从出生缺陷的角度,通过对妇女怀孕年龄及胎次与胎儿畸形患病率的关系对开放二胎政策之后的人口质量的影响进行分析,发现孕妇年龄过低(19岁以下)与过高(35岁以上)均会导致出生缺陷率提高;而胎次的影响比较复杂,对于24岁以下的年龄段来说,胎次越高,患病率越高,而对于25-44岁的孕妇来说,除了第4胎及以上的患病率较高,第2、3胎的患病率没有明显的差别。因此,放开二胎将不会对人口质量产生显著影响。

  7. The Impact of Age of Pregnancy and Birth Order on Birth Defects%怀孕年龄与胎次对出生缺陷的影响分析

    Institute of Scientific and Technical Information of China (English)

    张帆; 李骅; 米红

    2015-01-01

    Based on the 5782 cases of patients from the Attached of Obstetrical and Gynecological Hospital of Zhejiang University , the paper analyzes the impacts of pregnant age and birth order on the fetal defect rate as well as impacts of the fetal defect on the population quality at the policy of two-children for all families. It is found that the pregnant age lower than 19 and older than 35 can cause the increase of fetal defect rate , while the birth order impact the birth defect rate in different ways , the higher the birth order is , for those mothers younger than 24 , the higher rate of birth defect and for the mothers aged 25-44 there is no increase of birth defect rate for their second and third child birth but with a relatively higher birth defects for their fourth child birth. It seems that the birth defect rate of second child have no negative impacts on population quality even after the permit of second child birth for all families in future.%本研究通过抽取浙江大学医学院附属妇产科医院某病区5782个病例(736例患病),从出生缺陷的角度,通过对妇女怀孕年龄及胎次与胎儿畸形患病率的关系对开放二胎政策之后的人口质量的影响进行分析,发现孕妇年龄过低(19岁以下)与过高(35岁以上)均会导致出生缺陷率提高;而胎次的影响比较复杂,对于24岁以下的年龄段来说,胎次越高,患病率越高,而对于25-44岁的孕妇来说,除了第4胎及以上的患病率较高,第2、3胎的患病率没有明显的差别。因此,放开二胎将不会对人口质量产生显著影响。

  8. 北京61272例新生儿出生缺陷监测结果分析%Analysis of the birth defects among 61 272 live born infants in Beijing

    Institute of Scientific and Technical Information of China (English)

    李瑛; 刘晓红; 王粉燕; 赵心亮; 张羲; 张运平

    2009-01-01

    Objective: To investigate the birth defect condition in Haidian district of Beijing city, 61 272 live-born infants who were delivered in Haidian Maternal and Child Health Hospital from 2003 to the March of 2009 are analyzed. Methods: Data was collected from the hospital' s medical records and from the birth defect surveillance. Results: Among the newborns studied, 1 076 were found having birth defect (17.56‰). The most common birth defects are congenital heart defect, followed by dysmorphosis of external ear, polydactyly, hypospadia, cleft lip and palate. In addition, three birth defects that are not included in the birth defect surveillance list were enorchia, renal agenesis and giant hemangioma. The birth defect rates of preterm and small for gestational age infants are significantly higher than it of the term infants. The birth defect patterns for these two types of abnormal infants are distinct. Conclusion: We have determined the pattern of birth defects in Beijing, which may help in policy-making regarding the prevention and intervention of birth defects.

  9. Clinical analysis of 31 cases birth defects fetus withtherapeutic induced labor%治疗性引产31例缺陷儿临床分析

    Institute of Scientific and Technical Information of China (English)

    吴清明; 周瑾

    2012-01-01

    目的 探讨产前诊断对出生缺陷疾病诊断的临床意义,提高产前诊断率,降低出生缺陷发生率.方法 通过孕期系统B超、产前筛查、染色体病产前诊断方法进行产前检查,分析2009年9月~2010年12月本院产前诊断的出生缺陷胎儿病例资料.结果 2549例孕妇通过系统B超、产前筛查、染色体病产前诊断等技术共诊断并引产缺陷胎儿31例,出生缺陷检出率为1.22%.结论 通过产前超声检查、产前筛查技术、羊水染色体检查,及早地发现缺陷儿并及时终止妊娠,是减少出生缺陷发生的有效措施.%Objective: To explore the clinical significance of prenatal diagnosis for birth defects, improve the detection rate of birth defects and reduce the incidence of birth defects. Methods; To do prenatal care by systematic ultrasound examination prenatal screening and chromosomal diagnosis. We have analyzed the birth defects from September 2009 to December 2010. Results: 31 cases of birth defects were diagnosed by obstetric examination during pregnancy. The detecting rate of birth defect was 1. 22%. Conclusion; It is an effective measure to reduce birth defect by prenatal screening, prenatal diagnosis and therapeutic induced labor.

  10. The Nexus of Prematurity, Birth Defects, and Intrauterine Growth Restriction: A Role for Plac1-Regulated Pathways

    Science.gov (United States)

    Fant, Michael E.; Fuentes, Juan; Kong, Xiaoyuan; Jackman, Suzanne

    2013-01-01

    Epidemiological studies have demonstrated an increased prevalence of birth defects and intrauterine growth restriction (IUGR) among infants born prematurely suggesting they share common biological determinants. The identification of key regulatory pathways contributing to this nexus is essential to ongoing efforts to develop effective intervention strategies. Plac1 is a paternally imprinted and X-linked gene that conforms to this paradigm. Examination of a mutant mouse model has confirmed that Plac1 is essential for normal placental development and function. Moreover, it is expressed throughout the developing embryo indicating that it also has broad relevance to embryogenesis. Most notably, its absence in the developing embryo is associated with abnormal brain development and an increased risk of lethal, postnatal hydrocephalus identifying it as a novel, X-linked determinant of brain development. The essential and non-redundant roles of Plac1 in placental and neurological development represent a novel regulatory paradigm for embryonic growth and pregnancy maintenance. Regulatory pathways influenced, in part, by Plac1 are likely to contribute to the observed nexus of IUGR, prematurity, and birth defects. PMID:24600606

  11. Conjoined Twins: A Worldwide Collaborative Epidemiological Study of the International Clearinghouse for Birth Defects Surveillance and Research

    Science.gov (United States)

    MUTCHINICK, OSVALDO M.; LUNA-MUÑOZ, LEONORA; AMAR, EMMANUELLE; BAKKER, MARIAN K.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; DUTRA, MARIA DA GRAÇA; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, BRIAN; MARENGO, LISA K.; MARTÍNEZ-FRÍAS, MARÍA-LUISA; MASTROIACOVO, PIERPAOLO; MÉTNEKI, JULIA; MORGAN, MARGERY; PIERINI, ANNA; RISSMAN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SIFFEL, CSABA; SZABOVA, ELENA; ARTEAGA-VÁZQUEZ, JAZMÍN

    2015-01-01

    Conjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. The process by which monozygotic twins do not fully separate but form CT is not well understood. The purpose of the present study was to analyze diverse epidemiological aspects of CT, including the different variables listed in the Introduction Section of this issue of the Journal. The study was made possible using the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) structure. This multicenter worldwide research includes the largest sample of CT ever studied. A total of 383 carefully reviewed sets of CT obtained from 26,138,837 births reported by 21 Clearinghouse Surveillance Programs (SP) were included in the analysis. Total prevalence was 1.47 per 100,000 births (95% CI: 1.32–1.62). Salient findings including an evident variation in prevalence among SPs: a marked variation in the type of pregnancy outcome, a similarity in the proportion of CT types among programs: a significant female predominance in CT: particularly of the thoracopagus type and a significant male predominance in parapagus and parasitic types: significant differences in prevalence by ethnicity and an apparent increasing prevalence trend in South American countries. No genetic, environmental or demographic significant associated factors were identified. Further work in epidemiology and molecular research is necessary to understand the etiology and pathogenesis involved in the development of this fascinating phenomenon of nature. PMID:22002822

  12. Monitoring and analysis of perinatal birth defect%围产儿出生缺陷的监测与分析

    Institute of Scientific and Technical Information of China (English)

    梁海丽; 陈源鸿; 王丽平; 蔡娟; 温新创

    2012-01-01

    Objective Analysis of epidemiology and influencing factors of perinatal birth defects from 2002 to 2010. Method The defect rate of perinatal birth and influencing factors were analyzed based on the birth defect surveillance data and the birth information from Nanshan Hospital, Guangdong Medical College. Results The birth defect rate was 15.88‰ over the period of nine years,and it was significantly increased since 2007.The death rate of defect birth accounted for 24.88% of the total perinatal death. The top birth defects were congenital heart disease, multi-fingered and jointed fingered, total cleft lip and palate, fetal edema syndrome, and neural tube malformations, accounted for 52.55% of total birth defects. The birth defect was related to residence origin of the parents, gender and number of the neonates, season of the birth, as well as pregnant times, delivery times, age and education levels of the pregnant women. Conclusion The control of birth defect is critical.Further investigations on the etiology of birth defect are needed to provide effective prevention and control strategies.Extensive health education and guidance on marriage and pregnancy, prenatal and post natal cares,and physical examination on neonates are the effective ways to reduce the rate of birth defects and increase the quality of population.%目的 分析2002-2010年围产儿出生缺陷流行病学特征及影响因素.方法 以2002-2010年广东医学院附属南山医院分娩信息及出生缺陷的监测资料为基础,对缺陷率及影响因素进行分析.结果 9年间出生缺陷率为15.88%,2007年后缺陷率明显增高;缺陷儿死亡占围产儿死亡的24.88%;前五位出生缺陷依次为先天性心脏病、多指+并指、总唇腭裂、胎儿水肿综合征、神经管畸形,共占畸形总数的52.55%;出生缺陷发生与户籍、性别、季节、胎数及产妇年龄、文化程度、孕次、产次有关.结论 出生缺陷防控形势严峻,应深入

  13. Characteristics of rural birth defects and intervention strategies%农村出生缺陷特征及干预对策临床研究分析

    Institute of Scientific and Technical Information of China (English)

    黄蓉; 杨妹; 陈娟文; 吴秋婵; 林怡

    2015-01-01

    目的:探讨我市农村出生缺陷的临床特征,为临床制订干预措施提供科学依据。方法:对我市农村出生缺陷的发生率和特征进行临床分析,与城市出生缺陷进行比较。结果:我市农村出生缺陷发生率为73.51/万,城乡出生缺陷发生率有显著差异,农村出生缺陷发生率比城市高近一倍,(P均<0.005),农村出生缺陷前三位依次为消化系统畸形、四肢畸形和神经系统畸形,分别占出生缺陷的28.39%、24.15%和11.86%。结论:我市农村出生缺陷发生率还处于较高水平,而且神经系统出生缺陷比较突出,主要原因是农村育龄妇女对口服叶酸预防出生缺陷等措施不理解、不接受,思想认识还未真正提高;基层围产保健水平低。我市农村人口占80%以上,因此,在制定出生缺陷干预对策时,应将重点放在影响人力资源与人民生活质量的病种和农村上。%Goal To investigate the clinical characteristics of birth defects in our city, and to provide scientific basis for clinical intervention. Methods the incidence and characteristics of birth defects in rural areas were analyzed, and compared with the urban birth defects. Finally The city rural birth defect rate 73.51/, urban and rural birth defect rate has the remarkable difference, rural incidence of birth defects rate nearly one times higher than that of urban, respectively (P<0.005). The rural birth defects in the former three followed by digestive system malformations, limb deformities and nervous system malformation, respectively, accounting for birth defects of 28.39%and 24.15%and 11.86%. Discussion our city rural birth defects incidence is still at a higher level and nervous system of birth defects is more outstanding, main reason is rural women of childbearing age oral folic acid to prevent birth defects and other measures do not understand, do not accept and ideas have not really improve;primary Wai care

  14. Advances in prenatal screening and prenatal diagnosis for birth defect%出生缺陷产前筛查及产前诊断研究进展

    Institute of Scientific and Technical Information of China (English)

    吴清明; 周瑾

    2011-01-01

    出生缺陷已成为世界婴儿死亡、儿童和成人残疾的主要原因之一,是目前全世界关注的一个重大公共卫生问题.出生缺陷由遗传因素、环境致畸因素或两者共同作用所致.我国是出生缺陷高发国家,通过早期诊断、早期干预可以避免至少70%出生缺陷.出生缺陷干预是一个系统工程,产前筛查和产前诊断是胎儿出生缺陷干预的有效手段,是出生缺陷干预二级预防中的重要组成部分.%Birth defects has been one of main causes of infant mortality, children and adult disability, and are becoming main public heath problem worldwide. Birth defects are associated with environmental factors, genetic factors or interactions of the genetic factors and environmental factors. It is high rates of birth defects in China, at least 70% of the birth defects can be avoided of early diagnosis is determined and early interventions are performed. Intervention of birth defects is a system process, prenatal screening and prenatal diagnosis are effective interventions, and they are the key components of the secondary prevention in birth defects control.

  15. Multivitamins, Folic Acid and Birth Defects: Knowledge, Beliefs and Behaviors of Hispanic Women in North Carolina

    Science.gov (United States)

    deRosset, Leslie; Mullenix, Amy; Zhang, Lei

    2009-01-01

    Background: Consumption of folic acid prior to conception can prevent up to 70% of neural tube defect (NTD)-affected pregnancies. In 1992, the U.S. Public Health Service (USPHS) issued a recommendation that all women of childbearing age capable of becoming pregnant consume 400 [mu]g of folic acid daily to reduce their risk for a NTD-affected…

  16. Birth Defects in Newborns: Spina Bifida Index at Rio Grande Do Norte State in Brazil

    Directory of Open Access Journals (Sweden)

    Arnaldo CM Junior

    2014-08-01

    Conclusion: Northeast region is the one that has the major incidence of SB in Brazil country, but RN state has a number lower than others states from its region. It was made an update about therapeutic options to minimize the morbidity and mortality in newborn with SB congenital defects. [J Interdiscipl Histopathol 2014; 2(4.000: 217-223

  17. Specific Association of Teratogen and Toxicant Metals in Hair of Newborns with Congenital Birth Defects or Developmentally Premature Birth in a Cohort of Couples with Documented Parental Exposure to Military Attacks: Observational Study at Al Shifa Hospital, Gaza, Palestine

    Directory of Open Access Journals (Sweden)

    Paola Manduca

    2014-05-01

    Full Text Available This study was undertaken in Gaza, Palestine, in a cohort of babies born in 2011. Hair samples of newborns were analyzed for metal load by DRC-ICP-MS. We report specific level of contamination by teratogen/toxicants metals of newborn babies, environmentally unexposed, according to their phenotypes at birth: normal full term babies, birth defects or developmentally premature. The occurrence of birth defects was previously shown to be correlated in this cohort to documented exposure of parents to weapons containing metal contaminants, during attacks in 2009. We detect, in significantly higher amounts than in normal babies, different specific teratogen or toxicant elements, known weapons’ components, characteristic for each of birth defect or premature babies. This is the first attempt to our knowledge to directly link a phenotype at birth with the in utero presence of specific teratogen and/or toxicant metals in a cohort with known episodes of acute exposure of parents to environmental contamination by these same metals, in this case delivered by weaponry The babies were conceived 20–25 months after the major known parental exposure; the specific link of newborn phenotypes to war-remnant metal contaminants, suggests that mothers’ contamination persists in time, and that the exposure may have a long term effect.

  18. 出生缺陷影响因素的病例对照研究%Case-control study on influence factors of birth defects

    Institute of Scientific and Technical Information of China (English)

    修新红; 袁丽; 王晓明; 陈玉华; 万爱华; 傅平

    2011-01-01

    Objective To investigate the influence factors of birth defects. Methods The congenital malformational fetuses born from 13 week of gestation to 7 days after birth were selected as the study group between April 1st, 2009 and March 31st, 2010. The health born fetuses were set as control in the same period. Case-control and the three-level of monitor network of birth defects were used in the study in the participating 75 hospitals (Qingdao Women and Children's Medical Center, Affiliated Hospital of Medical College Qingdao University, Qingdao Municipal Hospital, etc.) . The study and control group's parents were interviewed by an uniformed questionnaire which was designed specially with influence factors of birth defects. Results (1) There are 466 congenital malformational fetuses in the total of 77 231 fetuses collected in 75 hospitals. The congenital malformational rate accounts for about 6. 034‰. The top six defect diseases were congenital heart disease (112 cases) , total harelip (cleft lip; cleft lip with palate; 85 cases) ,polydactyly (53 cases) , neural tube defects (38 cases) , congenital hydrocephalus (37 cases) and limb reduction defect (27 cases) in turn, which amounts to 353 cases (54.48% , 353/648). (2) Their mother education level in the birth-defect group (25. 6%) were significantly lower than that in control group (30. 0% , P < 0. 05). (3) The rate of passive smoking, drinking, raising pets of the parents in birth-defect group were significantly higher than that in control group (P < 0. 05). (4) The rate of exposure to harmful chemical and physical factors of mothers in birth defects group (13.9% and 20. 5% , respectively) was higher than that in control group (1.1% and 11.7% , respectively) , the difference between which were significant (P < 0. 01) . The rate of disease (34. 3%) , fever (13. 1%) , taking drugs (33. 8%) in pregnancy period in birth defect group were higher than that in control group (13. 5% , 1.5% and 9. 9% ,respectively) , the

  19. 10年围产儿出生缺陷调查研究%Investigation and analysis of perinatal birth defects during 10 years

    Institute of Scientific and Technical Information of China (English)

    管淑彩; 李敏; 刘青

    2012-01-01

    目的 探讨出生缺陷的状况及其影响因素,为降低出生缺陷干预措施的制定提供依据.方法 回顾性监测分析我院2001年1月至2010年12月10年间分娩的围产儿出生缺陷状况.结果 10年监测17 365例围产儿,其中出生缺陷儿205例,平均出生缺陷发生率为11.81‰,总体出生缺陷的年度发生率间无显著性差异(χ2=4.303,P=0.890>0.05),但2006年至2010年与2001年至2005年相比,神经管畸形的构成比明显下降(17.09%vs29.55%,χ2=4.474,P=0.034 0.05 ). But compared with the period of 2001-2005, the constituent ratio of neural tube defect at the period of 2006-2010 decreased significantly ( 17.09% vs 29. 55% ,χ2 = 4. 474,P = 0.034 <0.05,OR =0. 492 ). The first 5 types of birth defect were neural tube defect, polysyndactyly, cheilopalatognathus, urinary tract defect and congenital cardiopathy in turn, and the incidence rates of them were 2. 66 , 2.49 , 1. 22 , 1. 10 and 0. 98 , respectively. The sum of incidence of the first three types occupied 52. 69% of overall birth defect rate. The age of puerperants (x = 14. 946,P =0.000 <0. 05,OR = 1.712 ) and the gender of perinatal infants (χ2 = 6.488 ,P = 0. 011 <0. 05, OR = 1.440 ) were closely related with birth defect. There were 52. 20% of birth defect diagnosed before birth, and B-ultrasound was the main method for diagnosing ( 57. 07% ). Conclusion The incidence rate of birth defect in the area needs to be cut down, especially the types of neural tube defects, polysyndactyly and cheilopalatognathus. Low-dose of folic acid has significant effect in preventing neural tube defects.

  20. 我院1996-2011年出生缺陷监测分析%Monitoring of birth defects in our hospital from 1996 to 2011

    Institute of Scientific and Technical Information of China (English)

    张娟; 刘华平

    2013-01-01

    Objective To investigate the birth defects-related factors in order to take countermeasures against them. Methods Data about birth defects in our hospital from 1996 to 2011 were retrospectively analyzed. Results Of the 10 025 perinatal infants, 217 (21.65‰) had birth defects. The rate of birth defects was significantly lower in 1996-2003 than in 2004-2011. The birth defects were related with the maternal age, newborn gender, fever in the early gestational period, taking drugs and exposure to toxic or harmful substances. The incidence of congenital heart disease was the highest in perinatal infants with birth defects. B ultrasound plays an important role in prenatal examination. Conclusion The incidence of birth defects should be reduced by improving their prenatal diagnosis, strengthening the good birth and good care awareness and enhancing the population quality.%  目的了解新生儿出生缺陷的相关因素,制定干预措施。方法对1996-2011年我院围产儿的出生缺陷情况进行回顾性分析。结果10025例围产儿中,出生缺陷217例,发生率21.65‰。1996-2003年的出生缺陷率明显低于2004-2011年,出生缺陷与孕母年龄、新生儿性别以及孕早期发热、服用药物、接触有毒有害物质有关。出生缺陷中先天性心脏病的发生率最高,而且明显升高。B超在产前检查中起重要作用。结论提高产前诊断水平,加强优生优育意识,降低出生缺陷的发生,提高人口素质。

  1. 我院1996-2011年出生缺陷监测分析%Monitoring of birth defects in our hospital from 1996 to 2011

    Institute of Scientific and Technical Information of China (English)

    张娟; 刘华平

    2013-01-01

      目的了解新生儿出生缺陷的相关因素,制定干预措施。方法对1996-2011年我院围产儿的出生缺陷情况进行回顾性分析。结果10025例围产儿中,出生缺陷217例,发生率21.65‰。1996-2003年的出生缺陷率明显低于2004-2011年,出生缺陷与孕母年龄、新生儿性别以及孕早期发热、服用药物、接触有毒有害物质有关。出生缺陷中先天性心脏病的发生率最高,而且明显升高。B超在产前检查中起重要作用。结论提高产前诊断水平,加强优生优育意识,降低出生缺陷的发生,提高人口素质。%Objective To investigate the birth defects-related factors in order to take countermeasures against them. Methods Data about birth defects in our hospital from 1996 to 2011 were retrospectively analyzed. Results Of the 10 025 perinatal infants, 217 (21.65‰) had birth defects. The rate of birth defects was significantly lower in 1996-2003 than in 2004-2011. The birth defects were related with the maternal age, newborn gender, fever in the early gestational period, taking drugs and exposure to toxic or harmful substances. The incidence of congenital heart disease was the highest in perinatal infants with birth defects. B ultrasound plays an important role in prenatal examination. Conclusion The incidence of birth defects should be reduced by improving their prenatal diagnosis, strengthening the good birth and good care awareness and enhancing the population quality.

  2. Sirenomelia : An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research, and Literature Review

    NARCIS (Netherlands)

    Orioli, Ieda M.; Amar, Emmanuelle; Arteaga-Vazquez, Jazmin; Bakker, Marian K.; Bianca, Sebastiano; Botto, Lorenzo D.; Clementi, Maurizio; Correa, Adolfo; Csaky-Szunyogh, Melinda; Leoncini, Emanuele; Li, Zhu; Lopez-Camelo, Jorge S.; Lowry, R. Brian; Marengo, Lisa; Martinez-Frias, Maria-Luisa; Mastroiacovo, Pierpaolo; Morgan, Margery; Pierini, Anna; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Castilla, Eduardo E.

    2011-01-01

    Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance system m

  3. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and the risk of selected birth defects: a prospective cohort study

    NARCIS (Netherlands)

    Gelder, M.M.H.J. van; Roeleveld, N.; Nordeng, H.

    2011-01-01

    BACKGROUND: Since use of non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy is common, small increases in the risk of birth defects may have significant implications for public health. Results of human studies on the teratogenic risks of NSAIDs are inconsistent. Therefore, we evaluated

  4. Amelia : A Multi-Center Descriptive Epidemiologic Study in a Large Dataset from the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature

    NARCIS (Netherlands)

    Bermejo-Sanchez, Eva; Cuevas, Lourdes; Amar, Emmanuelle; Bakker, Marian K.; Bianca, Sebastiano; Bianchi, Fabrizio; Canfield, Mark A.; Castilla, Eduardo E.; Clementi, Maurizio; Cocchi, Guido; Feldkamp, Marcia L.; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Siffel, Csaba; Szabova, Elena; Martinez-Frias, Maria-Luisa

    2011-01-01

    This study describes the epidemiology of congenital amelia (absence of limb/s), using the largest series of cases known to date. Data were gathered by 20 surveillance programs on congenital anomalies, all International Clearinghouse for Birth Defects Surveillance and Research members, from all conti

  5. Association between prenatal exposure to antiretroviral therapy and birth defects: an analysis of the French perinatal cohort study (ANRS CO1/CO11.

    Directory of Open Access Journals (Sweden)

    Jeanne Sibiude

    2014-04-01

    Full Text Available BACKGROUND: Antiretroviral therapy (ART has major benefits during pregnancy, both for maternal health and to prevent mother-to-child transmission of HIV. Safety issues, including teratogenic risk, need to be evaluated. We estimated the prevalence of birth defects in children born to HIV-infected women receiving ART during pregnancy, and assessed the independent association of birth defects with each antiretroviral (ARV drug used. METHODS AND FINDINGS: The French Perinatal Cohort prospectively enrolls HIV-infected women delivering in 90 centers throughout France. Children are followed by pediatricians until 2 y of age according to national guidelines. We included 13,124 live births between 1994 and 2010, among which, 42% (n = 5,388 were exposed to ART in the first trimester of pregnancy. Birth defects were studied using both European Surveillance of Congenital Anomalies (EUROCAT and Metropolitan Atlanta Congenital Defects Program (MACDP classifications; associations with ART were evaluated using univariate and multivariate logistic regressions. Correction for multiple comparisons was not performed because the analyses were based on hypotheses emanating from previous findings in the literature and the robustness of the findings of the current study. The prevalence of birth defects was 4.4% (95% CI 4.0%-4.7%, according to the EUROCAT classification. In multivariate analysis adjusting for other ARV drugs, maternal age, geographical origin, intravenous drug use, and type of maternity center, a significant association was found between exposure to zidovudine in the first trimester and congenital heart defects: 2.3% (74/3,267, adjusted odds ratio (AOR = 2.2 (95% CI 1.3-3.7, p = 0.003, absolute risk difference attributed to zidovudine +1.2% (95% CI +0.5; +1.9%. Didanosine and indinavir were associated with head and neck defects, respectively: 0.5%, AOR = 3.4 (95% CI 1.1-10.4, p = 0.04; 0.9%, AOR = 3.8 (95% CI 1.1-13.8, p = 0

  6. Risk factors for non-syndromic holoprosencephaly in the National Birth Defects Prevention Study.

    Science.gov (United States)

    Miller, Eric A; Rasmussen, Sonja A; Siega-Riz, Anna Maria; Frías, Jaime L; Honein, Margaret A

    2010-02-15

    Holoprosencephaly (HPE) is a complex structural brain anomaly that results from incomplete cleavage of the forebrain. The prevalence of HPE at birth is low, and risk factors have been difficult to identify. Using data from a large multi-state population-based case-control study, we examined risk factors for non-syndromic HPE. Data from maternal telephone interviews were available for 74 infants with HPE and 5871 controls born between 1997 and 2004. Several characteristics and exposures were examined, including pregnancy history, medical history, maternal diet and use of nutritional supplements, medications, tobacco, alcohol, and illegal substances. We used chi(2)-tests and logistic regression (excluding women with pre-existing diabetes) to examine associations with HPE. Except for diet (year before pregnancy) and sexually transmitted infections (STIs) (throughout pregnancy), most exposures were examined for the time period from the month before to the third month of pregnancy. HPE was found to be associated with pre-existing diabetes (chi(2) = 6.0; P = 0.01), aspirin use [adjusted odds ratio (aOR) = 3.4; 95% confidence interval (CI) 1.6-6.9], lower education level (aOR = 2.5; 95%CI 1.1-5.6), and use of assisted reproductive technologies (ART) (crude OR = 4.2; 95%CI 1.3-13.7). Consistent maternal folic acid use appeared to be protective (aOR = 0.4; 95%CI 0.2-1.0), but the association was of borderline statistical significance. While some of these findings support previous observations, other potential risk factors identified warrant further study. PMID:20104597

  7. Analysis on monitoring results of 554 cases with birth defects%554例出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    黄彩练

    2011-01-01

    Objective; To understand the prevalence, change trend and related factors of birth defects in liuyang city, provide a basis for making intervening measures. Methods; According to the requirements of brochure of birth defect monitoring of Chinese, the fetuses and infants whose mothers lived in 37 villages, towns and streets (including natives or those who had lived in Liuyang city for more than one year) were monitored from October first, 2006, the monitoring time was from 28 gestational weeks to 42 days after birth. Results; The incidence of birth defects was 108.70 per ten thousand, the incidence of birth defects in rural areas was 114. 28 per ten thousand, which was significantly higher than that in urban areas (64. 58 per ten thousand) (X2 = 11. 68, P < 0.01) . The mortality of perinatal infants was 7.93%0, the mortality of perinatal infants with birth defects was 3. 55%0, accounting for 44. 80% , birth defect was a main cause of perinatal death. The top five birth defects were accessory auricle, polydactyly, congenital heart disease, cleft lip with or without cleft palate and talipes equinovarus. Conclusion: Health education should be carried out widely among the population of childbearing age, supplement of folic acid should be popularized, health care before pregnancy and during the first trimester of pregnancy should be enhanced, the factors inducing birth defects should be avoided, consultation about prepotency, prenatal examination and prenatal diagnosis should be conducted, all the a-bove - mentioned measures are effective to reduce the occurrence of birth defects.%目的:了解浏阳市出生缺陷的发生状况、变化趋势及相关因素,为制定干预措施提供依据。方法:按照《中国人群出生缺陷监测手册》要求,从2006年10月1日起对居住在浏阳市37个乡、镇、街道产妇(包括本地户口及非本地户口在浏阳市居住1年以上的产妇)的胎婴儿进行人群监测,监测期限为孕满28周~产后42天

  8. Study on Birth Defect Intervention and Standardization Mode%出生缺陷干预及规范化模式的研究

    Institute of Scientific and Technical Information of China (English)

    刁文强; 幸惠云

    2015-01-01

    Objective:To study and explore the intervention of birth defects on the effect of themarried couples, in order to reduce the birth rate of birth defects, improve the comprehensive quality of the birth population reference.Method: 12 000 married couples in our region from June 2011 to May 2014 were selected as the research objects, and they were given birth defect intervention on its three. The first level intervention was to prevent the birth of children with birth defects, secondary interventions was to reduce the incidence of birth defects, three intervention was to treat children of birth defects. Interventions focus was on primary intervention to prevent birth defects in children born.District,town,village three level of division of labor,cooperation, for marriedcouples of childbearing age premarital examination,free eugenics propaganda and education,pre pregnancy virus and genetic disease detection, pre pregnancy and early pregnancytaking free pregnancy B ultrasound examination,Fu Shi Fu,regular follow-up.Result:Premarital education to carry out rate,pre-marital medical examination rate,pregnancy B-examination and regular follow-up of the number of persons in 2014 were significantly higher than those of 2013,2012 and 2011(P<0.05).Early pregnancy rates of four viruses tested positive for the virus (rubella virus,herpes virus, Toxoplasma gondii, cytomegalovirus), a genetic disease before pregnancy rate (thalassemia,G6PD deficiency) in 2014 were significantly higher than those of 2013, 2012 and 2011(P<0.05).And the number of women in early pregnancy taking Forceval was significantly higher than that of 2013,2012 and 2011.The birth defect rate in 2014 was significantly lower than that in 2013,2012,2011(P<0.05), the intensity was positively correlated with the level of intervention.Conclusion:For married women of childbearing age of birth defect intervention, especially the level of intervention, to the birth of children with birth defects play a preventive role

  9. 出生缺陷干预及规范化模式的研究%Study on Birth Defect Intervention and Standardization Mode

    Institute of Scientific and Technical Information of China (English)

    刁文强; 幸惠云

    2015-01-01

    Objective:To study and explore the intervention of birth defects on the effect of themarried couples, in order to reduce the birth rate of birth defects, improve the comprehensive quality of the birth population reference.Method: 12 000 married couples in our region from June 2011 to May 2014 were selected as the research objects, and they were given birth defect intervention on its three. The first level intervention was to prevent the birth of children with birth defects, secondary interventions was to reduce the incidence of birth defects, three intervention was to treat children of birth defects. Interventions focus was on primary intervention to prevent birth defects in children born.District,town,village three level of division of labor,cooperation, for marriedcouples of childbearing age premarital examination,free eugenics propaganda and education,pre pregnancy virus and genetic disease detection, pre pregnancy and early pregnancytaking free pregnancy B ultrasound examination,Fu Shi Fu,regular follow-up.Result:Premarital education to carry out rate,pre-marital medical examination rate,pregnancy B-examination and regular follow-up of the number of persons in 2014 were significantly higher than those of 2013,2012 and 2011(P<0.05).Early pregnancy rates of four viruses tested positive for the virus (rubella virus,herpes virus, Toxoplasma gondii, cytomegalovirus), a genetic disease before pregnancy rate (thalassemia,G6PD deficiency) in 2014 were significantly higher than those of 2013, 2012 and 2011(P<0.05).And the number of women in early pregnancy taking Forceval was significantly higher than that of 2013,2012 and 2011.The birth defect rate in 2014 was significantly lower than that in 2013,2012,2011(P<0.05), the intensity was positively correlated with the level of intervention.Conclusion:For married women of childbearing age of birth defect intervention, especially the level of intervention, to the birth of children with birth defects play a preventive role

  10. The Danish Cerebral Palsy Registry. A registry on a specific impairment

    DEFF Research Database (Denmark)

    Uldall, P; Michelsen, Susan Ishøy; Topp, M;

    2001-01-01

    Cerebral palsy (CP) is the commonest disabling impairment in childhood, with a prevalence of 2-3 per 1000 live births. The Danish Cerebral Palsy Registry is a research registry that contains cases of CP from birth year 1925 and has estimated the birth prevalence since 1950. Data on children with CP...... are collected from paediatric departments and one special institution for disabled children. The children are included by a child neurologist and an obstetrician, and information on pregnancy, birth, neonatal period, impairments and demographic data on the child and mother are registered in a standard form...

  11. Phocomelia: A Worldwide Descriptive Epidemiologic Study in a Large Series of Cases From the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature

    Science.gov (United States)

    Bermejo-Sánchez, Eva; Cuevas, Lourdes; Amar, Emmanuelle; Bianca, Sebastiano; Bianchi, Fabrizio; Botto, Lorenzo D.; Canfield, Mark A.; Castilla, Eduardo E.; Clementi, Maurizio; Cocchi, Guido; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Siffel, Csaba; Szabova, Elena; Martínez-Frías, María-Luisa

    2015-01-01

    Epidemiologic data on phocomelia are scarce. This study presents an epidemiologic analysis of the largest series of phocomelia cases known to date. Data were provided by 19 birth defect surveillance programs, all members of the International Clearinghouse for Birth Defects Surveillance and Research. Depending on the program, data corresponded to a period from 1968 through 2006. A total of 22,740,933 live births, stillbirths and, for some programs, elective terminations of pregnancy for fetal anomaly (ETOPFA) were monitored. After a detailed review of clinical data, only true phocomelia cases were included. Descriptive data are presented and additional analyses compared isolated cases with those with multiple congenital anomalies (MCA), excluding syndromes. We also briefly compared congenital anomalies associated with nonsyndromic phocomelia with those presented with amelia, another rare severe congenital limb defect. A total of 141 phocomelia cases registered gave an overall total prevalence of 0.62 per 100,000 births (95% confidence interval: 0.52–0.73). Three programs (Australia Victoria, South America ECLAMC, Italy North East) had significantly different prevalence estimates. Most cases (53.2%) had isolated phocomelia, while 9.9% had syndromes. Most nonsyndromic cases were monomelic (55.9%), with an excess of left (64.9%) and upper limb (64.9%) involvement. Most nonsyndromic cases (66.9%) were live births; most isolated cases (57.9%) weighed more than 2,499 g; most MCA (60.7%) weighed less than 2,500 g, and were more likely stillbirths (30.8%) or ETOPFA (15.4%) than isolated cases. The most common associated defects were musculoskeletal, cardiac, and intestinal. Epidemiological differences between phocomelia and amelia highlighted possible differences in their causes. PMID:22002800

  12. Rational Reflections about Euthanasia of Newborn with Birth Defect%对缺陷新生儿安乐死问题的理性思考

    Institute of Scientific and Technical Information of China (English)

    高华

    2012-01-01

    Currently, there is semi-open and hidden euthanasia of newborn with birth defects. Due to great family burden, social tolerance and the incomplete relevant legislation of birth defect, this phenomenon has existed for a long time. In order to avoid abuse, disordered and protect the interests of non-serious defects newborn, this article suggests that it should develop regulations as an important component of the birth defect intervention legislation.%分析目前我国存在着的半公开的、隐蔽的缺陷新生儿安乐死行为,因家庭负担、社会宽容态度和相关法律不完善致使该现象长期存在.当务之急是制定缺陷新生儿处置法规并将其作为整个出生缺陷干预立法的重要组成部分,以此来避免缺陷新生儿安乐死行为的滥用和无序,保障成千上万非严重缺陷新生儿的生命权益.

  13. 2008-2010年围产期出生缺陷分析%2008-2010 years perinatal birth defect analysis

    Institute of Scientific and Technical Information of China (English)

    景丽丽

    2011-01-01

    Objective: in order to know the QingShanOu incidence of birth defects, this paper discusses the related factors birth defects happen for formulating and take measures to provide the basis. Methods: according to the national birth defects monitoring scheme, at the request of (2008-2010) on October 1, 2007-October 31, 2010 QingShanOu 5 home delivery hospital inpatient delivery at full and thoughtful within 7 days after perinatal infants dead for monitoring. Results: three years were monitoring perinatal infants dead 11 850 cases, birth defects in 104 cases, de- fect rate of 8.8%, which was born in 2008 to 3.6 per 2009, defects in 10.1%~, in 2010 to 13.2 per thousand. Birth defects increasing year by year, the top five birth defects is as follows: (1) the outer ear malformation; (2) by and means; Cleft palate (3); (4) foot deformity; (5) head facial deformity. Mother from air pollution in the area close to significantly higher than the far from air pollution area, mother of low degree of culture birth defects son is obviously higher than that of the culture degree is high. The occurrence of the birth defects and gender no phase relationship. Conclusion: to widely develop health education, general knowledge level of eugenic and superior nurture, strengthen the examination before marriage, prenatal care and prenatal diagnosis work.%目的:了解青山区出生缺陷发生率,探讨出生缺陷发生的相关因素,为制定和采取预防干预措施提供依据。方法:按照全国出生缺陷监测方案的要求,对(2008-2010年)2007年10月1日-2010年10月31日青山区5家分娩医院住院分娩的孕满28周到产后7天内围产儿进行监测。结果:3年共监测围产儿11850例,出生缺陷儿104例,缺陷发生率为8.8%,其中2008年出生缺陷率为3.6%。、2009年为10.1%。、2010年为13.2%。。出生缺陷呈逐年上升趋势,前5位出生缺陷依次为:①外耳畸

  14. 武汉市出生缺陷相关因素分析%Analysis on the related factors of birth defect in Wuhan city

    Institute of Scientific and Technical Information of China (English)

    张斌; 杨蓉; 刘明珠; 刘艳; 胡荣华; 杜玉开

    2011-01-01

    Objective; To understand the current situation of birth defect in Wuhan city from 2008 to 2010, explore the related effect factors of birth defect, provide a basis for further study. Methods; The data of birth defect were collected from 11 obstetrical institutions in Wuhan, 933 infants with birth defect were selected as case group, 933 lying - in women who gave birth to normal neonates from 2008 to 2010 were selected from Wuhan MCH information system as control group, the related data were obtained according to report cards of birth defect and MCH information system, then statistical analysis was performed. Results; The incidence of birth defect in Wuhan city from 2008 to 2010 was 17.77% , the incidence of birth defect in remote urban area was significantly higher than that in central urban area ( P <0.01); the incidence of birth defect among the lying - in women less than 25 years, equal to and more than 35 years were significantly higher than that among the lying - in women aged 25 ~35 years old (P <0.01) ; 11 factors, such as gravida, fetal gender, being ill during the first trimester of pregnancy, were used as independent variables for logistic regression analysis, the result showed that permanent address during pregnancy, being ill during the first trimester of pregnancy and spontaneous abortion history were included into the modeL Living in remote urban area, viral infection and hyperemesis gravidarum during the first trimester of pregnancy, spontaneous abortion history ( more than two times) increased the risk of birth defect. Conclusion; Primary prevention of birth defect should be paid more attention to, large - scale case - control study based on population should be carried out, and the epidemiological factors of birth defect should be understood, in order to a-dopt corresponding interventional measures and reduce the occurrence of birth defect.%目的:了解2008~2010年武汉市出生缺陷发生的情况,弄清对出生缺陷发生有影响的相关

  15. Monitoring analysis of birth defects from 2009 to 2010 in Guangzhou%广州市2009至2010年出生缺陷监测分析

    Institute of Scientific and Technical Information of China (English)

    邹兴文; 王平; 杨丽

    2011-01-01

    目的 探讨广州市2009至2010年出生缺陷发生率、发生类型、转归及影响因素.方法 收集并分析广州市全部148家医院在2009至2010年期间分娩儿出生缺陷监测资料.结果 共监测352 084例围产儿,发生出生缺陷5 724例,出生缺陷发生率162.6/万,前五位缺陷类型依次是先天性心脏病、多指(趾)、总唇腭裂、马蹄内翻足和外耳其他畸形.男性围产儿的出生缺陷发生率高于女性(177.74/万 vs 144.66/万,P<0.05),早产儿的出生缺陷发生率高于足月儿(756.40/万 vs 122.19/万,P<0.05),孕母年龄越大,发生出生缺陷的风险越高(P<0.05).严重出生缺陷的治疗性引产率超过60%.结论 广州市出生缺陷发生率偏高,应重视对男婴、早产儿的先天畸形检查,加强对高龄孕妇的管理.提高产前确诊率和致死性畸形的治疗性引产率.%Objective To explore the incidence, type, outcomes and influencing factors of birth defects in Guangzhou from 2009 to 2010. Methods The data of birth defects during this period from all of 148 hospitals in Guangzhou was collected and analyzed. Results Among 352 084 perinatal infants monitored, 5724 cases were detected with birth defects with incidence of 162. 6 per ten thousand. The first five birth defects were congenital heart disease, polydactylia, total cheiloschisis/palatoschisis, congenital talipes equino varus and deformity of external ear in order. The incidence of birth defects in boys was higher than that in girls (177. 74/ten thousand vs 144. 66/ten thousand, P < 0. 05 ), and it was higher in premature infants than term infants ( 756. 40/ten thousand vs 122. 19/ten thousand, P < 0. 05 ). The older the pregnant women were, the greater the risk of birth defects was. The rate of therapeutic termination of severe birth defects was more than 60%. Conclusion The incidence of birth defects is slightly high in Guangzhou. Attention should be paid to malformation examination on male infants and

  16. 426例出生缺陷儿产前超声诊断分析%Cases study on 426 birth defects monitoring

    Institute of Scientific and Technical Information of China (English)

    赵玉环

    2012-01-01

    目的 探讨我院分娩的出生缺陷儿临床类型与产前超声诊断分析,为孕期早期诊断出生缺陷提供科学依据.方法 回顾性分析我院2001年至2009年共分娩28 311例,出生缺陷儿426例,发生率15‰,产前超声诊断269例,(检出率63.1%),我院采取产科超声检查三个重点时间段进行筛查(孕龄10 -14周,22-26周及32 -36周)检测胎儿发育情况.结果 孕龄14 -27周超声检查出生缺陷人工终止妊娠92例(21.59%),出生缺陷发生率前五位依次为:神经管畸形(21.8%),唇腭裂(16.9%),多指并指(趾)畸形(10.01%),胎儿水肿(9.85%),外耳畸形(4.22%),产前超声检出率分别为:95.69%,50.72%,9.30%,80.95%,0,结论 产前超声诊断除神经管畸形,胎儿水肿,唇腭裂外,其它发病率较高的畸形超声检出率较底,因此加强产前诊断人员的技术培训,提高超声诊断技术水平,是提高人口素质降低出生缺陷的重要措施.%Objective: Study the birth defects type and the prebirth monitoring result at the hospital in order to improve the diagnosis of birth defects. Methord; All toghter there are 28 311 births at the hospital, and 426 birth defects were found. The frequency is 1.5%. 426 cases were diagnosed by prebirth monitoring (63. 1%). The monitoring was done at three key points of the pregnancy. (10-14 week, 22-26 week, 32 - 36week). Results: 92 birth defects cases were found and the pregnancy terminated. The most likely occurred five birth defects are neural tube defects (21. 8% ), cheilopalatognathus (16. 9% ), polysyndactyly (10.01%), fetus edema (9.85% ), deformity of external ear (4.22% ). And the monitoring diagnosis rate are: 95.69% , 50.72% , 9.30% , 80. 95% , 0. Conclusion: the monitoring diagnosis rate of birth defects is low except neural tube defects, fetus edema and cheilopalatognathus. Therefor, improving the successful diagnosis of birth diagnosis throught technology and training is essential for population quality

  17. Study on the Secondary Prevention Strategy for Birth Defects%出生缺陷二级预防策略的研究

    Institute of Scientific and Technical Information of China (English)

    宋桂荣; 肖绪武; 孙瑾; 刘启贵

    2013-01-01

    Objective:To evaluate and compare the economic effectiveness of three strategies of the sec-ondary prevention for birth defects in order to provide the basis for the prevention decision on congenital disa-bilities .Methods:A decision tree model was used to make a decision analysis on the cost-effectiveness of the three strategies .Results :The birth defects detection rates of three strategies were 82 .82% ,98 .2% ,94 . 50% respectively .The cost of one birth defect detected of the third strategy was lowest .Conclusions :In-creasing an ultrasound screening for high-risk pregnant women is an economical and effective strategy to pre-vent birth defects .%目的:评价、比较出生缺陷的3种二级预防策略的经济学效果,为有效预防先天性残疾提供决策依据。方法:采用决策树模型,对3种策略的成本-效果进行比较。结果:3种策略的出生缺陷检出率分别为82.82%、98.2%、94.50%,策略3成本/效果比最低。结论:高危孕妇增加超声筛查是一种既经济又有效的预防策略。

  18. Clinical Case Registries (CCR)

    Data.gov (United States)

    Department of Veterans Affairs — The Clinical Case Registries (CCR) replaced the former Immunology Case Registry and the Hepatitis C Case Registry with local and national databases. The CCR:HIV and...

  19. Stroke Trials Registry

    Science.gov (United States)

    ... News About Neurology Image Library Search The Internet Stroke Center Trials Registry Clinical Trials Interventions Conditions Sponsors ... a clinical trial near you Welcome to the Stroke Trials Registry Our registry of clinical trials in ...

  20. Preventing Birth Defects

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    NERVIDUCT malformation caught the attention of the Chinese government in 1983 when professor Yan Renying, now director of the China Maternal and Infant Health Care Center, conducted an epidemiological survey of new-borns in Shunyi County, Beijing, and discovered that one-third of infant mortality in the area was caused by

  1. Birth Defects Diagnosis

    Science.gov (United States)

    ... quad screen tests the levels of 4 proteins AFP (alpha-fetoprotein), hCG, estriol, and inhibin-A. Generally, ... of the proteins for which an amniocentesis tests. AFP AFP stands for alpha-fetoprotein, a protein the ...

  2. Atenção aos defeitos congênitos no Brasil: panorama atual Birth defects and health strategies in Brazil: an overview

    Directory of Open Access Journals (Sweden)

    Dafne Dain Gandelman Horovitz

    2005-08-01

    Full Text Available O impacto dos defeitos congênitos no Brasil vem aumentando progressivamente, tendo passado da quinta para a segunda causa dos óbitos em menores de um ano entre 1980 e 2000, apontando para a necessidade de estratégias específicas na política de saúde. Foram localizadas, no Brasil, direcionadas aos defeitos congênitos, ações governamentais e não-governamentais. Estas envolvem serviços de informação sobre agentes teratogênicos na gravidez e sobre doenças metabólicas geneticamente determinadas, monitorização de defeitos congênitos, programa de triagem neonatal e tratamento de algumas doenças genéticas, imunização contra rubéola, além da fortificação de farinhas com ácido fólico como ação preventiva de certos defeitos congênitos. Apesar da importância de tais iniciativas, é pouco provável que seja possível atender à questão dos defeitos congênitos de forma integrada. Para a efetivação de um sistema de atenção voltado aos defeitos congênitos, deverá ser formulada política específica, de âmbito nacional, com a participação ativa do Ministério da Saúde, utilizando, como espinha dorsal, os serviços de genética existentes. Só assim, será possível a estruturação de uma rede regionalizada, hierarquizada e funcional voltada à atenção aos defeitos congênitos no Brasil.Birth defects have increased progressively in Brazil, shifting from the fifth to the second cause of infant mortality from 1980 to 2000, thus highlighting the need for specific health policy strategies. Some governmental and nongovernmental actions related to birth defects in Brazil include information services on teratogenic agents and inborn errors of metabolism, monitoring of birth defects, neonatal screening and treatment of some genetic diseases, and rubella immunization. In addition, flour fortification with folic acid for prevention of certain birth defects has begun recently. Despite the importance of such initiatives, it is

  3. Clinical Analysis in 265 Perinatals Birth Defects%265例出生缺陷儿的临床分析

    Institute of Scientific and Technical Information of China (English)

    董红霞

    2012-01-01

      Objective To characterize the distribution patterns of birth defects in Huai-rou First Hospital 2006-2011. Methods Birth defects surveillance data in the period of January 2002 to December 2004 were analyzed. Results The overall prevalence rate of birth defects was 207.97/10,000 births. The first 5 common birth defects were hyperdactylism and ankylodactylia, accessory auricle,congenital heart disease,total cleft lip and palate,pigmented mole. chromosomal abnormalities,and neural tube defects. Conclusion To disease the prevalence rate of birth defects and elevate the disposition of the birth population, we should put the emphasis to preservation(the third-level prevention).%  目的 分析我院住院分娩围生儿的出生缺陷发生情况、变化趋势,为进一步预防出生缺陷的发生提供依据.方法 对2006至2011年在怀柔区第一医院住院分娩的围生儿出生缺陷监测资料进行分析.结果 6年共监测围生儿12742例,发现缺陷儿265例,平均出生缺陷发生率为207.97/万,前5位分别是多指(趾)及并指(趾)36例,副耳34例,先天性心脏病33例,唇裂合并腭裂23例,色素痣13例.结论 减少出生缺陷的工作重点在预防,应加强优生知识的宣传,提高产前检查质量及产前诊断技术,做好三级预防工作,以期降低围生儿出生缺陷的出生率,提高出生人口素质.

  4. Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature

    Science.gov (United States)

    SIFFEL, CSABA; CORREA, ADOLFO; AMAR, EMMANUELLE; BAKKER, MARIAN K.; BERMEJO-SÁNCHEZ, EVA; BIANCA, SEBASTIANO; CASTILLA, EDUARDO E.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; CSÁKY-SZUNYOGH, MELINDA; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, R. BRIAN; MARENGO, LISA K.; MASTROIACOVO, PIERPAOLO; MORGAN, MARGERY; MUTCHINICK, OSVALDO M.; PIERINI, ANNA; RISSMANN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SZABOVA, ELENA; OLNEY, RICHARD S.

    2015-01-01

    Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention. PMID:22002949

  5. 2010年常州市围产儿出生缺陷及城市功能区出生缺陷状况%Birth defects of perinatal infants in Changzhou city in 2010 and birth defects in different functional areas of the city

    Institute of Scientific and Technical Information of China (English)

    缪金剑; 周华; 蒋健

    2012-01-01

    Objective: To understand the birth defects in Changzhou city in 2010 and the birth defects in different functional areas of the city, explore the related factors of occurrence of birth defects in Changzhou city. Methods: The perinatal infants with birth defects who were bom in obstetric department of all the hospitals in Changzhou city in 2010 were collected, and the city was divided into central urban area, industrial area, and agricultural area according to the functions of the city, the birth defects of perinatal infants were compared among different functional areas. Results: There were 39 399 perinatal infants in 2010, the incidence of birth defects was 5.10‰, the incidence of birth defects and the top three birth defects were in accord with those from 2007 to 2009, the mean incidence of birth defects in Changzhou city was 5.10‰, and the incidences of birth defects in industrial area, central urban area, and agricultural area were 9.13‰, 4.60‰, and 3. 24‰, respectively, the incidence of birth defects in industrial area was significantly higher than the mean level in Changzhou city. Among the perinatal infants with birth defects, the indexes including floating population, gestational smoking or passive smoking, drinking during pregnancy, engaging in high risk works were higher than those of normal control group; the rate of medical examination before marriage and the regular examination rate during gestational period were lower than those in normal control group. Conclusion: Premarital check - up and pregestational health care should be enhanced, the management of reproductive health of the floating population should be improved, and the prenatal examination rate of birth defects should be strengthened, the measures above - mentioned can be conducted to reduce the incidence of birth defects.%目的:了解常州市2010年出生缺陷发生情况以及城市功能区出生缺陷状况,探讨常州市出生缺陷发生的相关因素.方法:收集2010

  6. 奉贤区13266例围产儿出生缺陷分析%Analysis on 13 266 perinatal infants with birth defects in Fengxian district

    Institute of Scientific and Technical Information of China (English)

    顾维红

    2011-01-01

    目的:了解奉贤区出生缺陷发生情况、分布特征、影响因素,为降低出生缺陷发生制定干预措施提供依据.方法:采用回顾性方法对2008年1月1日~2009年12月31日奉贤区13 266例监测围产儿进行分析.结果:①奉贤区两年间出生缺陷儿188例,出生缺陷率为14.17%;②出生缺陷前5位分别是先天性心脏病、多指(趾)、总唇裂、血管瘤和神经管畸形;③出生缺陷发生在男女性别、户籍、出生时间方面差异无统计学意义,但与孕妇年龄有关(x2=7.517,P<0.05);④出生缺陷儿死亡与非出生缺陷儿死亡差异有统计学意义(x2=1 345.85,P<0.001);⑤产前诊断及治疗性终止妊娠可降低活产婴儿的出生缺陷发生率,并使出生缺陷顺位发生改变.结论:出生缺陷发生与孕妇年龄有关,与性别、受孕时间、户籍无关;出生缺陷儿死亡是围产儿死亡的主要原因;做好三级预防是降低出生缺陷发生,降低围产儿死亡率的重要措施.%Objective: To understand the occurrence, distribution characteristics and effect factors of birth defects in Fengxian distriet, provide a basis for making intervention measures to reduce the occurrence of birth defects. Methods: A retrospective method was adopted to analyze 13 266 perinatal infants in Fengxian district from January 1,2008 to December 31,2009. Results: From 2008 to 2009,188 perinatal infants with birth defects were born in Fengxian district, the incidence of birth defects was 14. 17‰; the first five birth defects were congenital heart disease, polydaetylism, total cleft lip, hemangioma and neural tube defect; there was no significant difference in incidences of birth defects between the perinatal infants with different genders, census registers and times of birth, but the incidences of birth defects were related to maternal age (x2 = 7. 517, P < 0. 05 ); there was significant difference in perinatal mortality between the perinatal infants with birth

  7. Amelia: A Multi-Center Descriptive Epidemiologic Study in a Large Dataset from the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature

    Science.gov (United States)

    BERMEJO-SÁNCHEZ, EVA; CUEVAS, LOURDES; AMAR, EMMANUELLE; BAKKER, MARIAN K.; BIANCA, SEBASTIANO; BIANCHI, FABRIZIO; CANFIELD, MARK A.; CASTILLA, EDUARDO E.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, R. BRIAN; MASTROIACOVO, PIERPAOLO; MUTCHINICK, OSVALDO M.; RISSMANN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SIFFEL, CSABA; SZABOVA, ELENA; MARTÍNEZ-FRÍAS, MARÍA-LUISA

    2015-01-01

    This study describes the epidemiology of congenital amelia (absence of limb/s), using the largest series of cases known to date. Data were gathered by 20 surveillance programs on congenital anomalies, all International Clearinghouse for Birth Defects Surveillance and Research members, from all continents but Africa, from 1968 to 2006, depending on the program. Reported clinical information on cases was thoroughly reviewed to identify those strictly meeting the definition of amelia. Those with amniotic bands or limb-body wall complex were excluded. The primary epidemiological analyses focused on isolated cases and those with multiple congenital anomalies (MCA). A total of 326 amelia cases were ascertained among 23,110,591 live births, stillbirths and (for some programs) elective terminations of pregnancy for fetal anomalies. The overall total prevalence was 1.41 per 100,000 (95% confidence interval: 1.26–1.57). Only China Beijing and Mexico RYVEMCE had total prevalences, which were significantly higher than this overall total prevalence. Some under-registration could influence the total prevalence in some programs. Liveborn cases represented 54.6% of total. Among monomelic cases (representing 65.2% of nonsyndromic amelia cases), both sides were equally involved, and the upper limbs (53.9%) were slightly more frequently affected. One of the most interesting findings was a higher prevalence of amelia among offspring of mothers younger than 20 years. Sixty-nine percent of the cases had MCA or syndromes. The most frequent defects associated with amelia were other types of musculoskeletal defects, intestinal, some renal and genital defects, oral clefts, defects of cardiac septa, and anencephaly. PMID:22002956

  8. Health Care for Certain Children of Vietnam Veterans and Certain Korea Veterans--Covered Birth Defects and Spina Bifida. Final rule.

    Science.gov (United States)

    2016-04-01

    This rule adopts as final a proposed rule of the Department of Veterans Affairs (VA) to amend its regulations concerning the provision of health care to birth children of Vietnam veterans and veterans of covered service in Korea diagnosed with spina bifida, except for spina bifida occulta, and certain other birth defects. In the proposed rule published on May 15, 2015, VA proposed changes to more clearly define the types of health care VA provides, including day health care and health-related services, which we defined as homemaker or home health aide services that provide assistance with Activities of Daily Living or Instrumental Activities of Daily Living that have therapeutic value. We also proposed changes to the list of health care services that require preauthorization by VA. This final rule addresses comments received from the public and adopts as final the proposed rule, without change. PMID:27051894

  9. Analysis of the Monitoring Results of Birth Defect in Hospitals Between 2001 and 2010 in Changsha%长沙市2001~2010年医院出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    祖月娥; 朱琳; 周红女; 周燕飞; 李杏秀; 王卫东; 徐扬; 林蓓蓓

    2013-01-01

    [Objective]To analyze the monitoring results of birth defect in hospital between 2001 and 2010 in Changsha in order to provide the basis for formulating the policy to reduce the birth defect rate of hospitals by health administrative department .[Methods] The statistical data from 13 birth defect monitoring hospitals of Changsha were analyzed .All the 13 hospital were accorded with birth defect definition and diagnostic standard in Chinese birth defect monitoring program and Chinese birth defect monitoring manual .All birth defect children were examined and registered by the trained physicians .The classification and statistical analysis were taken .[Results] In the past 10 years ,there were 173527 perinatal children born in 13 birth defect surveillance hospitals . Among them ,3856 children were birth defects .The total incidence rate was 222 .16/10000 .The incidence rate of birth defect during 10 years was increased obviously .The top 5 birth defects were congenital heart disease ,outer ear and other malformations ,cleft lip complicated with cleft palate ,multi-finger(toe) and congenital hydroceph-alus .Except the constituent ratio of congenital heart disease was increased ,the constituent ratio of 4 other birth defects had the declining trend .[Conclusion] The strategical change of the prevention mode of birth defect should be implemented so as to reduce the birth defect .%[目的]通过分析长沙市2001~2010年医院出生缺陷监测结果数据,为上级医疗行政部门制定降低医院出生缺陷率的政策提供依据。[方法]参照长沙市13所出生缺陷监测医院的统计数据。13所医院均按照《中国出生缺陷监测方案》及《中国出生缺陷监测手册》中有关出生缺陷的定义特征和诊断标准,经专职医生临床体检和相关检查确诊并分类统计。[结果]10年中13所出生缺陷监测医院总出生围生儿为173527例,出生缺陷3856例,总发生率为222.16/万,10年间出生缺

  10. Epidemiologic study of neural tube defects in Los Angeles County. I. Prevalence at birth based on multiple sources of case ascertainment

    Energy Technology Data Exchange (ETDEWEB)

    Sever, L.E. (Pacific Northwest Lab., Richland, WA); Sanders, M.; Monsen, R.

    1982-01-01

    Epidemiologic studies of the neural tube defects (NTDs), anencephalus and spina bifida, have for the most part been based on single sources of case ascertainment in past studies. The present investigation attempts total ascertainment of NTD cases in the newborn population of Los Angeles County residents for the period 1966 to 1972. Design of the study, sources of data, and estimates of prevalence rates based on single and multiple sources of case ascertainment are here discussed. Anencephalus cases totaled 448, spina bifida 442, and encephalocele 72, giving prevalence rates of 0.52, 0.51, and 0.08 per 1000 total births, respectively, for these neural tube defects - rates considered to be low. The Los Angeles County prevalence rates are compared with those of other recent North American studies and support is provided for earlier suggestions of low rates on the West Coast.

  11. Avaliação das declarações de nascido vivo como fonte de informação sobre defeitos congênitos Evaluation of the birth certificates as source of information on birth defects

    Directory of Open Access Journals (Sweden)

    Ana Lívia Geremias

    2009-03-01

    Full Text Available OBJETIVO: Estimar a prevalência de defeitos congênitos (DC em uma coorte de nascidos vivos (NV vinculando-se os bancos de dados do Sistema de Informação de Mortalidade (SIM e do Sistema de Informação sobre Nascidos Vivos (SINASC. MÉTODOS: Estudo descritivo para avaliar as declarações de nascido vivo como fonte de informação sobre DC. A população de estudo é uma coorte de NV hospitalares do 1º semestre de 2006 de mães residentes e ocorridos no Município de São Paulo no período de 01/01/2006 a 30/06/2006, obtida por meio da vinculação dos bancos de dados das declarações de nascido vivo e óbitos neonatais provenientes da coorte. RESULTADOS: Os DC mais prevalentes segundo o SINASC foram: malformações congênitas (MC e deformidades do aparelho osteomuscular (44,7%, MC do sistema nervoso (10,0% e anomalias cromossômicas (8,6%. Após a vinculação, houve uma recuperação de 80,0% de indivíduos portadores de DC do aparelho circulatório, 73,3% de DC do aparelho respiratório e 62,5% de DC do aparelho digestivo. O SINASC fez 55,2% das notificações de DC e o SIM notificou 44,8%, mostrando-se importante para a recuperação de informações de DC. Segundo o SINASC, a taxa de prevalência de DC na coorte foi de 75,4%00 NV; com os dados vinculados com o SIM, essa taxa passou para 86,2%00 NV. CONCLUSÕES: A complementação de dados obtida pela vinculação SIM/SINASC fornece um perfil mais real da prevalência de DC do que aquele registrado pelo SINASC, que identifica os DC mais visíveis, enquanto o SIM identifica os mais letais, mostrando a importância do uso conjunto das duas fontes de dados.OBJECTIVE: To obtain the prevalence of birth defects in a live birth cohort, linking the live birth information system (SINASC and the mortality information system (SIM databases. METHODS: Descriptive study to assess linked databases of hospital live births (LB and neonatal deaths of resident mothers that occurred in the city of S

  12. Use of folic acid and delivery outcome: a prospective registry study.

    Science.gov (United States)

    Källén, Bengt A J; Olausson, Petra Otterblad

    2002-01-01

    Periconceptional use of folic acid is thought to reduce the risk for both neural tube defects and other congenital malformations. Most published data were obtained retrospectively. We used the Swedish Medical Birth Registry to study congenital malformations in infants born of women who reported the use of folic acid in early pregnancy (of which 70% probably used it also preconceptionally) and compared them with population rates. We divided the material according to two major confounders: subfertility problems and use of antiepileptic drugs. We found no protective effect of folic acid tablet use on the rate of congenital malformations but data on neural tube defects were scarce. Our results support the scepticism recently expressed in the literature on the beneficial effect of folic acid in preventing congenital malformations, especially of a non-neural tube defect type.

  13. Closure of varicella-zoster virus-containing vaccines pregnancy registry - United States, 2013.

    Science.gov (United States)

    Marin, Mona; Willis, English D; Marko, Ann; Rasmussen, Sonja A; Bialek, Stephanie R; Dana, Adrian

    2014-08-22

    Vaccines that contain live attenuated varicella-zoster virus (VZV) (Varivax, ProQuad, and Zostavax [all products of Merck & Co., Inc.]) are contraindicated during pregnancy. To monitor the pregnancy outcomes of women inadvertently vaccinated with VZV-containing vaccines immediately before or during pregnancy, Merck and CDC established the Merck/CDC Pregnancy Registry for VZV-Containing Vaccines in 1995. This report updates previously published summaries of registry data, provides the rationale for the closure of the registry, and describes plans for continued monitoring of the safety of these vaccines when inadvertently administered to pregnant women or immediately before pregnancy. From inception of the registry in 1995 through March 2012, no cases of congenital varicella syndrome and no increased prevalence of other birth defects have been detected among women vaccinated within 3 months before or during pregnancy. Although a small risk for congenital varicella syndrome cannot be ruled out, the number of exposures being registered each year (approximately two varicella-susceptible women exposed during the high-risk period for congenital varicella syndrome) is now too low to improve on the current estimate of the risk.

  14. Ethical aspects of soft tissue engineering for congenital birth defects in children--what do experts in the field say?

    NARCIS (Netherlands)

    Oerlemans, A.J.M.; Rodrigues, C.H.; Verkerk, M.A.; Berg, P.P. van den; Dekkers, W.J.M.

    2010-01-01

    This article is part of the EuroSTEC project, which aims at developing tissue engineering-based treatments for structural disorders present at birth. EuroSTEC is positioned at the intersection of three areas with their own ethical issues: (1) regenerative medicine, (2) research with pregnant women a

  15. Ethical aspects of soft tissue engineering for congenital birth defects in children : what do experts in the field say?

    NARCIS (Netherlands)

    Oerlemans, A.J.; Rodrigues, Catarina; Verkerk, M.A.; van den Berg, P.P.; Dekkers, W.J.M.

    2010-01-01

    This article is part of the EuroSTEC project, which aims at developing tissue engineering-based treatments for structural disorders present at birth. EuroSTEC is positioned at the intersection of three areas with their own ethical issues: (1) regenerative medicine, (2) research with pregnant women a

  16. Analysis of risk factors of birth defects in Shaanxi Province%陕西省出生缺陷的相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    杨杨; 曾令霞; 颜虹

    2011-01-01

    Objective To explore the factors influencing birth defects in Shaanxi Province and then provide scientific evidence for intervention strategies. Methods Stratified random cluster sampling method was adopted.Totally 124 towns were sampled from 12 counties of 9 cities in Shaanxi Province. Household survey was carried out among 13 273 women who were residents and had conceived from October 2007 to July 2009, and all of these women had 28 weeks' gestational age. We collected 7 531 complete questionnaires finished for the progestational and pregnant period. Unconditional logistic regression was performed to analyze the risk factors by using SPSS13.0software. Results The results of logistic regression showed that the risk factors for birth defects were by turns the birth defects history of patrilineal family (OR = 14. 283), poor mental state (OR = 10. 835), abnormal pregnancy and reproductive history (OR = 8. 264), mothers living in rural areas ( OR = 5. 067), the history of alcohol intake in pregnancy (OR = 4. 598), mother's age higher than 35 years (OR = 3. 696), exposure to agricultural chemicals during pregnancy (OR=3. 507), drinking strong tea during pregnancy (OR = 1. 993), taking folic acid during pregnancy (OR=0. 549) and higher family income per capita (OR = 0. 422), which were the protective factors of birth defects. Conclusion We should strengthen publicity in scientific knowledge of pre-natal and post-natal care,increase self-care consciousness of women of childbearing age, improve their living environment and change the unhealthy lifestyle. These strategies play a very important role in reducing the prevalence rate of birth defects in Shaanxi Province.%目的 探讨陕西省出生缺陷发生的影响因素,为采取有针对性的干预措施提供依据.方法 应用分层随机整群抽样方法,抽取陕西省9市12个区县共124个乡镇.对终止妊娠日期发生在2007年10月至2009年7月间且孕满28周的13273名妇女进行入户调查.要求

  17. Investigation and analysis of 0 ~14 years old children with birth defects in Three Gorges Reservoir Area%三峡库区0~14岁儿童出生缺陷调查与分析

    Institute of Scientific and Technical Information of China (English)

    马明福; 李川海; 杨皓; 付新云; 李家菊; 崔蓉; 张丹妍; 李安奇; 李练兵

    2013-01-01

    Objective:To understand Three Gorges Reservoir Area 7 counties 0 ~ 14 years old children's birth defects present situation,type,incidence,urban and rural children's birth defect occurrence,occurring at different positions of the situation,collect birth defects/genetic disease information data to prevent birth defects and provide the scientific basis.Methods:According to ICD-10 coding diseases listed design questionnaire,stratified cluster random sampling was used to the scene to carry out investigations on the 0 ~ 14 years old children suffering from birth defects.Results:There were 7 977 meals available questionnaire,including 24 types of birth defect with 158 people,and the incidence of birth defects was 19.81‰.The first 4 types of the study were cleft lip (73 cases,incidence 9.152‰) ; limb deformities (17 cases,incidence 2.137 ‰) ; hydrocephalus (14 cases,incidence 1.755‰) ; cardiac malformations (12 cases including 5 cases of boys and 7 cases of girls,incidence 1.504‰).There were 95 boys with the incidence of birth defects 22.37‰,63 girls with the incidence of birth defects 16.89 ‰.The boy's incidence of birth defects was obviously higher than that of girl (chi-square =204.44,P <0.005).There were 42 children with birth defects in 2 198 urban children (27.55%) and 116 children with birth defects in 5 779 rural children (72.45%).The urban children's birth defect rate was 19.11‰ and the countryside was 20.07‰.There was no statistical difference (chi-square =0.076,P =0.782) between them.Location was the first facial defects 86 cases (54.43%),the second for nerve defect 20 cases (12.66%),the third for limbs defect 17 cases (10.76%),the fourth for heart defects 12 cases (7.59%),the fifth for urogenital defect 6 patients (3.80%),other defects 17 cases (10.76%).There was significant difference (chi-square =34.11,P <0.01) between the first birth defects and other parts.Conclusion:Birth defects' monitoring area,monitoring time

  18. Epidemiologic study of neural tube defects in Los Angeles County. II. Etiologic factors in an area with low prevalence at birth

    Energy Technology Data Exchange (ETDEWEB)

    Sever, L.E.

    1982-01-01

    Epidemiologic characteristics of neural tube defect (NTD) births occurring in Los Angeles County, California, residents during the period 1966-1972 are presented. The prevalence at birth was 0.52/1000 births for anencephalus, 0.51/1000 for spina bifida, and 0.08/1000 for encephalocele, rates considered to be low for a predominantly white population. We hypothesized that environmental (nongenetic) factors are of less etiologic importance in a low-prevalence population than in areas or time periods with high prevalence. We tested that hypothesis by examining epidemiologic characteristics of NTDs in Los Angeles County and comparing them with high-prevalence populations. The data did not support a major etiologic role for environmental factors: (1) no significant differences between rates by month of birth or conception; (2) no significant association with maternal age or parity for anencephalus; for spina bifida a significant maternal age effect (P < 0.01) and for encephalocele a parity effect (P < 0.02); and (3) no significant relationship with father's occupational class for either anencephalus or encephalocele but a marginally significant (P < 0.05) inverse association for spina bifida when a statistic based on ordinal relationships was used. Findings supporting the importance of genetic factors in etiology included: (1) a high percentage of males; (2) a higher twin concordance rate than in high-prevalence populations; and (3) an anencephalus rate among blacks comparable with rates for blacks in other United States populations. Our findings in conjunction with those from other areas and times of low prevalence suggest environmental factors play a relatively insignificant role in the etiology of NTDs in such populations.

  19. 黄山市2006~2010年出生缺陷调查结果分析%The analysis of birth defects prevalence of Huangshan from 2006 to 2010

    Institute of Scientific and Technical Information of China (English)

    章世妹; 盛玮; 吉次秋; 胡红喜; 曾令芳; 冯建华; 汪丽霞

    2012-01-01

    Objective To investigate the epidemiological features of birth defects in Huangshan in order to determine the high - risk population and areas. Methods The birth defect condition was household surveyed among perinatal infants, including dead fetus stillbirths and therapeutic abortion ), and children aged 0 to 5 with their mothers underwent in - depth personal interviews and cluster sampling retrospective study on January f, 2006 to December 3f , 20f0 in 7 prefectures( counties ) covering f Of towns and 6 streets. The confirmation of the birth defects was based on clinical diagnosis. The categories were defined with National Birth Defect Monitoring Program. Results There were 981 birth defects diagnosed in 5 years. The incidence rate of birth defects was 158. 69 per 10000 infants. The incidence in male infants was 82. 82 per 10000 infants and 63. 57 per 10000 infants in female infants. The top birth defects were congenital heart disease, total cleft lip and palate, polydactyly, congenred hydrocephaly, urogenital abnormality and neural tube defects. Conclusion The current situation of birth defects among children aged 0 to 5 in Huangshan has been evaluated, which shows an upward trend year by year. The incidence is higher in country than that in city and higher in male infants than females, but the difference between them has no statistical significance. So the key point of the birth defect prevention should be put in country areas. The hygienic knowledge of pregnant woman should be enhanced, especially in the top 6 birth defects mentioned above. Additionally, we should explore the reason of the high incidence of birth defects in order to provide basis for further birth defect prevention.%目的 了解黄山市0~5岁儿童出生缺陷的发生率、种类及顺位,确定重点预防人群和区域.方法 采用个人访谈、整群回顾性调查的方法对黄山市三区四县101个乡镇和6个街道在2006年1月1日至2010年12月31日期间出生的围生

  20. Neural Tube Defects

    Science.gov (United States)

    Neural tube defects are birth defects of the brain, spine, or spinal cord. They happen in the ... that she is pregnant. The two most common neural tube defects are spina bifida and anencephaly. In ...

  1. Analysis of peripregnancy health care effects on birth defects%围孕期保健对出生缺陷的影响分析

    Institute of Scientific and Technical Information of China (English)

    刘葵; 吕海荣

    2014-01-01

    目的:分析围孕期保健对围产儿出生缺陷的影响。方法:选取西安市第四医院2013年10月1日~2013年12月25日收治1716例产妇为研究对象,对其临床资料进行回顾分析。结果:围孕期叶酸的补充可以显著降低神经管畸形的发生风险,差异有统计学意义(P<0.05);围孕期营养状况及孕妇的家庭收入等因素为减少出生缺陷发生的保护性因素,差异有统计学意义(P<0.05);出生缺陷的危险因素分别为孕妇接触职业危险因素、孕期患慢性病、孕期感冒、孕早期出血流产症状、孕期接触宠物、孕前或孕期房屋新装修、被动吸烟、孕期服药及孕期精神紧张或过度焦虑,差异有统计学意义(P<0.05)。结论:通过加强围孕期保健,减少和控制孕期危险因素,可以预防和减少出生缺陷,提高人口出生质量。%Objective:To analyze the confining effect of health care during pregnancy on perinatal birth defects.Methods:Xi'an City Fourth Hospital from October 1, 2013 to December 25, 2013 a total of 1716 cases of pregnant women as the research object, this was a retrospective a-nalysis of the clinical data.Results:Periconceptional folic acid supplementation could significantly reduce the risk of neural tube malformation, the difference was statistically significant (P<0.05);perioperative nutritional status and maternal family income and other factors as the protec-tive factor for reducing the incidence of birth defects, there was statistically significant difference (P <0.05);risk factors of birth defects were pregnant women contact occupation risk factors during pregnancy, chronic disease, pregnancy, abortion of early pregnancy bleeding symptoms of colds, pet contacting during pregnancy, before or during pregnancy, passive smoking, the new housing decoration medication during pregnancy and maternal stress or excessive anxiety, the difference was statistically

  2. Research on the secondary intervention mode of birth defects in Chengdu%成都市出生缺陷二级干预模式研究

    Institute of Scientific and Technical Information of China (English)

    杨柳; 冉隆蓉; 赵顺霞; 陈硕

    2011-01-01

    目的:积极建立出生缺陷二级干预网络,有效提高产前筛查率和诊断率,以降低成都市出生缺陷率.方法:自2009年起,成都市通过原有妇幼保健网络,采取依托产前诊断中心和分中心力量,发展产前筛查采血点和产前筛查机构的模式,初步建立起产前筛查网络,对辖区孕妇进行产前筛查和产前诊断.结果:通过积极发展产前筛查采血点和产前筛查机构,产前筛查工作迅速覆盖到所有区市县.与此同时,成都市政府出台出生缺陷干预规划,将产前筛奁率纳入卫生部门年度目标管理,极大地促进了产前筛查和诊断工作的开展.成都市产前筛查率从2008年的22.99%,提高到2009年的42.77%.结论:发展产前筛查采血点和产前筛查机构对建立产前筛查网络有积极作用,能迅速及持续实现筛查人群最大化,达到降低成都地区出生缺陷,提高人口素质的目的,值得推广应用.%Objective: To establish the secondary intervention network of birth defects actively, increase the prenatal screening rate and diagnosis rate effectively, in order to reduce the incidence of birth defects in Chengdu.Methods: Since 2009, based on the previous maternity and child care network, relying on prenatal diagnosis centers and sub - centers, the mode of blood collection points and institutions of prenatal screening was developed, prenatal screening network was established preliminarily, then prenatal screening and prenatal diagnosis were conducted among the pregnant women.Results: The prenatal screening work covered all the cities and counties by developing blood collection points and institutions of prenatal screening actively.At the same time, Chengdu municipal government issued birth defect intervention planning, prenatal screening rate was included into annual target management of health department, which promoted the development of prenatal screening and prenatal diagnosis works greatly.The prenatal screening

  3. 围产儿出生缺陷的相关危险因素分析%Analysis of Risk Factors of Perinatal Birth Defects

    Institute of Scientific and Technical Information of China (English)

    杨华

    2014-01-01

    Objective:To investigate the incidence of birth defects(BD)in eight hospitals of Erqi district in Zhengzhou,to explore correlation factors of BD,and to provide scientific basis for developing appropriate intervention strategies and measures for BD. Method:All new born were monitored and a 1:2 case-control study for BD was performed in 117 babies with BD in eight hospitals of Erqi district in Zhengzhou during one year. Simple and multivariate logistic regression models were used to identify the correlates of BD. Result:The incidence of birth defects was 183.41 per 10 000 live births. In multiple factors analysis,backward stepwise regression was used to fit the main effects of equation. The experience without progestational examination,partiality for a particular kind of food during early pregnancy, contacted chemical agent,maternal history of birth defects,unhealthy emotion,diseases history during pregnancy were risk factors of BD. Conclusion:We should propagandize health knowledge widely in the crowd to avoid risk factors of BD, and do well in health care of perinatal period to prevent and reduce the incidence of birth defects,so as to improve the quality of the population born in China.%目的:了解郑州市二七区内8家医院的出生缺陷发生率,分析其影响因素,为制定适宜的干预策略和措施提供科学依据。方法:对郑州市二七区内8家医院1年内分娩的围产儿进行监测,并对其中117例出生缺陷儿进行1:2病例对照,采用单因素、多因素logistic回归模型分析出生缺陷的影响因素。结果:出生缺陷的发生率为183.41/万。多因素logistic逐步回归分析结果显示:无孕前检查、孕早期偏食、孕期接触化学制剂、既往分娩缺陷儿史、孕期不良情绪、孕期患病史是发生出生缺陷的危险因素。结论:要普遍宣传健康知识,避免出生缺陷的危险因素,作好围产期保健工作,预防和减少出生缺陷的发生,提高我国出生人口素质。

  4. Ethical aspects of soft tissue engineering for congenital birth defects in children: what do experts in the field say?

    OpenAIRE

    Oerlemans, A.J.; Rodrigues, Catarina; Verkerk, M A; van den Berg, P. P.; Dekkers, W.J.M.

    2010-01-01

    This article is part of the EuroSTEC project, which aims at developing tissue engineering-based treatments for structural disorders present at birth. EuroSTEC is positioned at the intersection of three areas with their own ethical issues: (1) regenerative medicine, (2) research with pregnant women and fetuses, and (3) research with neonates. Because of the overlap of these three areas in this project, we can expect to be confronted with new ethical challenges. To be able to respond adequately...

  5. Analysis of the Influencing Factors on 170 Cases of Birth Defects in a Hospital, Guizhou%贵州省某医院170例新生儿出生缺陷的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    罗敏

    2012-01-01

    Objective: The paper aims of understanding the change of incidence of birth defects and its influencing factors, to provide the basis for birth defects prevention and intervention. Methods: Collected 170 cases of birth defects from the birth defects monitoring data in2003 - 2011 ,the chi-square test were used for analysis of the change of incidence of birth defects and its influencing factors. Results: The incidence of thebirth defects was 142.6 per million, the prenatal diagnosis rate is 17.65%, abnormal factors accounted for 41.12%; The first five rows of the birth defects are the Outer ear other deformities, multi-fingered, neural tube defects, clubfoot varus and limb shortening; Child born defective has a high incidence with mother below 20. Conclusion: Strengthening preconception care, prenatal care, prenatal screening and early pregnancy and pregnancy folic acid specification can be taken to prevent and reduce the incidence of birth defects.%目的:探讨新生儿出生缺陷的影响因素,为新生儿出生缺陷的预防和干预提供依据.方法:基于贵州省某医院2003 -2011年出生缺陷的监测数据,运用卡方检验分析170例新生儿出生缺陷的特征变化及其影响因素.结果:该院出生缺陷检出率为142.6/万,产前诊断率为17.65%,异常因素占41.12%;出生缺陷前5位分别为外耳其它畸形、多指、神经管缺陷、马蹄足内翻和肢体短缩;母亲年龄<20岁缺陷儿发生率较高.结论:加强孕前保健、孕期保健、产前筛查和孕前与孕早期叶酸规范服用,是当前预防和减少出生缺陷发生的主要工作.

  6. 深圳市298031例围产儿出生缺陷监测流行病学特征%Epidemiological characteristic of birth defect of 298031 perinatal in Shenzhen

    Institute of Scientific and Technical Information of China (English)

    丁蓉; 颜春荣; 龚林

    2012-01-01

    Objective: To study the cause and risk factors of birth defect and to reduce birth defect through institute health care and disease prevents measures. Methods: The birth defect was measured in all perinatal, including live birth, stillbirth, induced abortion and neonatal death, in all Shenzhen hospital from 2008 to 2009 according to Shenzhen uniform surveillance scheme. Results: Among 289 031 births, the incidence of birth defect was 16. 52‰ (4 924/298 031), live deformity was 13. 84‰ (4 125/298 031) . The incidence of birth defect was 69.42‰ (3 418/4 924) in floating population . The incidence of birth defect was 20. 34‰ in lower knowledge level puerpera and 20.41%p in puerpera age > 35 group, which was much higher than other age groups, the difference was significant (P < 0.025) . The rate of birth defect in mature puerperal was 71.45% (3518/4924) . The incidence of birth defect in congenital heart disease and body check was 9.95‰ (2 967/298 031), which took 60.25% (2 967/4 924) in all kind of defect Defect birth liability took 83. 77% (4 125/4 924 ) . Conclusion: The rate of un - unitary body check is higher. The prenatal detection should be strengthen. It is key for prevent birth defect to popularization pregnant hearth care knowledge, develop hearth care service, elect right age to pregnancy.%目的:研究深圳市出生缺陷的发生状况及相关危险因素,为减少出生缺陷制定预防保健措施提供依据.方法:按深圳市统一的监测方案,对2008~ 2009年深圳市所有医院孕20周-产后7天分娩的围产儿(包括活产、死胎、死产、引产及产后7天内死亡)进行出生缺陷监测.结果:289 031例围产儿中出生缺陷发生率为16.52%(4 924/298 031),活产畸形率为13.84‰ (4 125/298 031),缺陷发生在流动人口中的比例为69.42%(3 418/4 924).产母文化程度低、年龄>35岁组发病率分别为20.34‰、20.41‰,高于其他年龄组,经检验P<0.025,差异有统计学意义.

  7. 2007-2012年围产儿出生缺陷人群监测结果分析%Analysis of the monitoring results of perinatal birth defects in the crowd from 2007 to 2012

    Institute of Scientific and Technical Information of China (English)

    杨淑荣; 袁燕; 陆晓莉

    2014-01-01

    Objective:To analyze the monitoring data of population birth defect,to understand its prevalence and related factors,in order to provide evidence for the intervention measures.Methods:We analyzed the birth data of 23686 perinatal borned in 2007-2012,observed the structure and demographic characteristics of perinatal with birth defects,and found out the related influencing factors.Results:The average incidence of perinatal birth defects in 2007-2012 was 84.58/million.The top five occurrence of major birth defects were total cleft lip,multi finger(toe),neural tube defects,hydrocephalus,congenital heart disease and limb shortening,and the incidence were 18.94/million,11.78/million,7.15/million,6.31/million,5.05/million respectively. Maternal age and the incidence of birth defects linked.Conclusion:Prevention and cure of birth defects is a system engineering.It requires multi sectoral participation,and takes effective measures to reduce the incidence of birth defects.%目的:通过分析出生缺陷人群监测资料,了解其发生率及相关因素,为制定干预措施提供依据。方法:对2007-2012年出生的23686例围生儿的出生资料进行分析,观察围产儿出生缺陷的构成及人口学特征,找出相关影响因素。结果:2007-2012年围产儿出生缺陷平均发生率84.58/万,其中总唇裂、多指(趾)、神经管缺陷、脑积水和先天性心脏病、肢体短缩位居发生主要出生缺陷的前5位,其发生率分别为18.94/万、11.78/万、7.15/万、6.31/万、5.05/万;产妇年龄与出生缺陷的发生有关。结论:出生缺陷的防治是一项系统工程,需要多部门共同参与、采取有效的措施才能降低出生缺陷的发生。

  8. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight

    DEFF Research Database (Denmark)

    Jensen, Christine B; Storgaard, Heidi; Dela, Flemming;

    2002-01-01

    Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two...... were significantly lower in the LBW group. Insulin-stimulated glycolytic flux was significantly reduced, and suppression of endogenous glucose production was enhanced in the LBW group. Nevertheless, basal and insulin-stimulated rates of whole-body peripheral glucose disposal, glucose oxidation, lipid...

  9. Environmental pollution by depleted uranium in Iraq with special reference to Mosul and possible effects on cancer and birth defect rates.

    Science.gov (United States)

    Fathi, Riyad Abdullah; Matti, Lilyan Yaqup; Al-Salih, Hana Said; Godbold, Douglas

    2013-01-01

    Iraq is suffering from depleted uranium (DU) pollution in many regions and the effects of this may harm public health through poisoning and increased incidence of various cancers and birth defects. DU is a known carcinogenic agent. About 1200 tonnes of ammunition were dropped on Iraq during the Gulf Wars of 1991 and 2003. As a result, contamination occurred in more than 350 sites in Iraq. Currently, Iraqis are facing about 140,000 cases of cancer, with 7000 to 8000 new ones registered each year. In Baghdad cancer incidences per 100,000 population have increased, just as they have also increased in Basra. The overall incidence of breast and lung cancer, Leukaemia and Lymphoma, has doubled even tripled. The situation in Mosul city is similar to other regions. Before the Gulf Wars Mosul had a higher rate of cancer, but the rate of cancer has further increased since the Gulf Wars. PMID:23729095

  10. Related factors of birth defects%保定地区出生缺陷相关因素研究

    Institute of Scientific and Technical Information of China (English)

    余瑞欣; 侯雯莅; 王建

    2012-01-01

    Objective; To 80 261 cases of perinatal analysis of 889 cases of defective children, most of unknown causes, of which 183 cases had a number of reasons, through the analysis to understand the defects caused by a common cause of children. Methods; The case study method, one by one asked about the history. Results: A number of reasons, such as high fever, contact with a number of chemical raw materials, indiscriminate use of drugs during pregnancy, social factors are all caused by defects. Conclusion; The prevention of pregnancy cold, away from toxic substances, rational drug use and change the bad ideas in order to effectively prevent the occurrence of defects in children.%目的 通过80 261例围产儿分析,缺陷儿889例,大部分不明原因,其中183例有一些明确原因,通过对这些因素分析,了解引起缺陷儿的常见原因.方法 采用个案调查方法,逐一询问病史.结果 一些原因如高烧、接触一些化工原料、孕期乱用药物、社会因素等都是引起缺陷的原因.结论 预防孕期感冒、远离有毒物质、合理用药,改变不良观念从而有效预防缺陷儿的发生.

  11. The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

    Directory of Open Access Journals (Sweden)

    Matthieu Raveau

    2012-05-01

    Full Text Available Down syndrome (DS leads to complex phenotypes and is the main genetic cause of birth defects and heart diseases. The Ts65Dn DS mouse model is trisomic for the distal part of mouse chromosome 16 and displays similar features with post-natal lethality and cardiovascular defects. In order to better understand these defects, we defined electrocardiogram (ECG with a precordial set-up, and we found conduction defects and modifications in wave shape, amplitudes, and durations in Ts65Dn mice. By using a genetic approach consisting of crossing Ts65Dn mice with Ms5Yah mice monosomic for the App-Runx1 genetic interval, we showed that the Ts65Dn viability and ECG were improved by this reduction of gene copy number. Whole-genome expression studies confirmed gene dosage effect in Ts65Dn, Ms5Yah, and Ts65Dn/Ms5Yah hearts and showed an overall perturbation of pathways connected to post-natal lethality (Coq7, Dyrk1a, F5, Gabpa, Hmgn1, Pde10a, Morc3, Slc5a3, and Vwf and heart function (Tfb1m, Adam19, Slc8a1/Ncx1, and Rcan1. In addition cardiac connexins (Cx40, Cx43 and sodium channel sub-units (Scn5a, Scn1b, Scn10a were found down-regulated in Ts65Dn atria with additional down-regulation of Cx40 in Ts65Dn ventricles and were likely contributing to conduction defects. All these data pinpoint new cardiac phenotypes in the Ts65Dn, mimicking aspects of human DS features and pathways altered in the mouse model. In addition they highlight the role of the App-Runx1 interval, including Sod1 and Tiam1, in the induction of post-natal lethality and of the cardiac conduction defects in Ts65Dn. These results might lead to new therapeutic strategies to improve the care of DS people.

  12. Tobacco smoking and its consequences on reproductive health: the impact of a lifestyle choices including cigarette smoke exposure on fertility and birth defects.

    Science.gov (United States)

    Merritt, Travis; Mazela, Jan; Merritt, Allen

    2013-01-01

    There are several life style choices which may impact fertility and thus national birth rate. Epidemiological cohort studies indicates that modification of life style habits, among them nicotine consumption can influence reproductive health. Influence of tobacco smoking on reproductive health has to be analyzed within the context of the influence of body mass index, caffeine and alcohol consumption, exercise, maternal and paternal age, and stress. Approximately 27% Polish women and 23% Americans smoke cigarettes during their reproductive years. Cohort studies directly showed the relationship between nicotine consumption and decrease in fertility among smoking women. Besides there is evidence that smoking leads to higher rate of congenital heart defects, limbs abnormalities, central nervous malformations among infants born to smoking mothers. Finally, the relationship between smoking and decreased fertility should be of great concern since Polish fertility rate has dropped from 1989 till 2007 year from 2,1 to 1,27 respectively. Programs focused on improvement in national birth rate should focus also on decrease smoking rates among women.

  13. Holt Oram syndrome: a registry-based study in Europe

    DEFF Research Database (Denmark)

    Barisic, Ingeborg; Boban, Ljubica; Greenlees, Ruth;

    2014-01-01

    BACKGROUND: Holt-Oram syndrome (HOS) is an autosomal dominant disorder characterised by upper limb anomalies and congenital heart defects. We present epidemiological and clinical aspects of HOS patients using data from EUROCAT (European Surveillance of Congenital Anomalies) registries. METHODS...

  14. Perinatal surveillance of birth defects in Zhengzhou City%河南省郑州市各级医院出生缺陷儿监测情况分析

    Institute of Scientific and Technical Information of China (English)

    袁亚楠; 赵悦淑; 张展; 胡孟彩; 姚梅玲

    2013-01-01

    目的:动态分析郑州市各级医院出生缺陷发生情况,为出生缺陷预防提供决策依据.方法:对2011年7月~2012年6月郑州市各级医院正常分娩婴儿及治疗性引产的围产儿进行出生缺陷监测.结果:共监测围产儿138 376例,死亡1 408例,死亡率为10.18%.;出生缺陷儿1 315例,出生缺陷率为953.4‰;1 408例死亡围产儿中缺陷儿488例,占34.66%;≥35岁孕妇分娩围产儿出生缺陷率1 260.6%.;缺陷儿产前诊断率为45.40%,产前诊断的出生缺陷疾病前3位分别是先天性心脏病、总唇裂和先天性脑积水,出生后诊断的出生缺陷疾病前3位分别是多指(趾)、外耳畸形和总唇裂.结论:出生缺陷是围产儿死亡的主要原因,重视优生知识宣传,加强产前筛查,提高产前诊断技术是降低出生缺陷儿出生的关键.%Objective; To investigate the status of birth defects in Zhengzhou City, and to provide a evidence base for the countermeasures. Methods: Birth defects were monitored in the childbirths of normal deliveries and those of therapeutic induction of labor in the hospitals of Zhengzhou City, from July 2011 to June 2012. Results; The perinatal mortality was 10. 18% (1,408/138,376) , of which 34. 66% (488/1,408) were the deaths with birth defect( s). The incidence of birth defect( s) was 9.53/10,000 (1,315/128,376). The incidence of birth defect(s) in the children of the mothers over 35 years old was the highest (126.06/10,000). The prenatal diagnosis rate of birth defect(s) was45.40%. The top three birth defects prena-tally diagnosed were congenital heart disease, total cleft lip and congenital hydrocephalus, while the top three birth defects postnatally diagnosed were multi -finger (toe) , outer ear deformity and total cleft lip. Conclusion; Birth defects have become one of the major causes of perinatal deaths. Perinatal education and prenatal screening should be strengthened. The improved prenatal diagnostic techniques

  15. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight

    DEFF Research Database (Denmark)

    Jensen, Christine B; Storgaard, Heidi; Dela, Flemming;

    2002-01-01

    oxidation, exogenous glucose storage, and nonoxidative glucose metabolism were similar in the two groups. Insulin secretion was reduced by 30% in the LBW group, when expressed relative to insulin sensitivity (disposition index = insulin secretion x insulin action). We propose that reduced insulin......Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two...... physiological insulin levels (10 and 40 mU/m(2) per min), indirect calorimetry, and [3-(3)H]glucose. Insulin secretion was examined during an oral and intravenous glucose tolerance test. Fasting p-glucose was higher in the LBW group (5.6 +/- 0.1 vs. 5.4 +/- 0.1; P < 0.05). Basal plasma glycerol concentrations...

  16. Analysis of birth defect in Zhongshan city from 2008 to 2010%中山地区2008年-2010年出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    王莹; 万波; 李莉敏; 胡朝霞; 彭学鸣; 曾冠

    2012-01-01

    目的 了解中山市出生缺陷的发生及分布情况,及时发现影响出生缺陷的可疑因素,协助指导制定相应的干预措施,做好今后出生缺陷监控工作提供科学依据.方法 对2008年-2010年中山市各医院分娩的孕满28周~产后7天内出生的所有围产儿(包括活产、死胎、死产)进行出生缺陷监测,并对其发生率、顺位及诊断依据进行分析.结果 三年内中山市出生缺陷发生率为260.05/万,排位前五位分别是先天性心脏病、多指(趾)、马蹄内翻足、地中海贫血、总唇腭裂.中山市户籍人口和农村、流动人口的顺位和发生率有明显差异.结论 加强流动人口孕产妇的孕期保健管理,普及孕期产前筛查意识,提高出生缺陷产前筛查和产前诊断的准确性,早期发现,早期诊断,早期干预,预防性用药等可减少出生缺陷的发生%Objective: To understand the prevalence of birth defects in Zhongshan, to detect the suspicious factors of influencing birth defects, to divide to provide scientific basis for making countermeasures to prevent and control birth defects. Method; Connecting the all perinatal birth defects data, including fetal deaths, stillbirths, live births, which detected during the second pregnancy over 28 weeks to postnatal day 7, analyzing the incidence rate, the sequence and the basis diagnosis on of birth defects. Results: The incidence of birth defect is 260. 05 per ten thousand in recent three years. The first five birth defect were: congenital heart disease, combined or excessive fingers or toes ( polydactyly) , clubfoot, a- Mediterranean-anaemia, cleft lip and palate. The sequence and the incidence rate of birth defect were significant difference, between Registered population and floating population. Registered population and population in rural areas. Conclusion; In order to depress perinatal birth defect rate, we should pay more attention in not only to the work of education of the

  17. Birth defects in Yantai Yuhuangding Hospital during 2006 -2010%2006年-2010年烟台毓璜顶医院围产儿出生缺陷分析

    Institute of Scientific and Technical Information of China (English)

    曲鑫; 刘志芬; 李蕾; 徐爱群; 柳红杰

    2012-01-01

    Objective: To explore the situation, influencing factors, diagnosis of the birth defects in our hospital, so as to provide evidences for periconceptional care. Methods; 301 birth defects in a total of 22211 births were monitored from 2006 to 2010, the birth defect rate was 13. 55% (301/22211). The top 5 common birth defects were Cadiovascular disease, total cleft in lip and palate , synpolydactyly, anephrogenesis or Polycystic kidney and Genital malformation. There was significant difference in birth defect rate between puerperal at city and countryside (x2 = 24. 34, P < 0. 01). There was no significant difference in birth defect rate between puerperal at different age, with different educational status, or different gender of fetus, But, the birth defect rate were higher in the age below 25 and exceed 35 groups than the other group, and the birth defect rate decrease when the educational status of puerperal increase. 48. 17% (145/301 ) cases were confirmed in prenatal diagnosis, and the main method was Ultrasonic Diagnosis. Conclusions: The key to reduce the birth defect rate is the primary prevention. We should improve the quality of antenatal examination and prenatal diagnosis technology, reduce birth defects, and improve the population quality of newborn.%目的 探讨我院围产儿出生缺陷发生状况、影响因素及确诊手段,为探索开展围孕期保健提供依据.方法 对2006年- 2010年5年间在我院住院分娩出生围产儿的监测资料进行回顾性分析.结果 2006年- 2010年我院共出生22211例围产儿,出生缺陷共301例,出生缺陷发生率为13.55‰(301/22211).出生缺陷率位居前五位的分别为先天性心血管疾病、唇腭裂、多指与并指(趾)、单肾缺如及多囊肾、生殖器畸形.产妇城乡间出生缺陷发生率比较差异有统计学意义(x2=24.34,P<0.01).不同年龄、文化程度及胎儿性别比较,差异无统计学意义,但年龄<25岁及≥35岁的产妇其出生缺陷率

  18. The Virtual Observatory Registry

    CERN Document Server

    Demleitner, Markus; Sidaner, Pierre Le; Plante, Raymond L

    2014-01-01

    In the Virtual Observatory (VO), the Registry provides the mechanism with which users and applications discover and select resources -- typically, data and services -- that are relevant for a particular scientific problem. Even though the VO adopted technologies in particular from the bibliographic community where available, building the Registry system involved a major standardisation effort, involving about a dozen interdependent standard texts. This paper discusses the server-side aspects of the standards and their application, as regards the functional components (registries), the resource records in both format and content, the exchange of resource records between registries (harvesting), as well as the creation and management of the identifiers used in the system based on the notion of authorities. Registry record authors, registry operators or even advanced users thus receive a big picture serving as a guideline through the body of relevant standard texts. To complete this picture, we also mention comm...

  19. Facility Registry Service (FRS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Facility Registry Service (FRS) provides an integrated source of comprehensive (air, water, and waste) environmental information about facilities across EPA,...

  20. Assessing the Risk of Birth Defects Associated with Exposure to Fixed-Dose Combined Antituberculous Agents during Pregnancy in Rats

    Directory of Open Access Journals (Sweden)

    O. Awodele

    2012-01-01

    Full Text Available Due to the risks of disease progression and transmission to the newborn, treatment of tuberculosis is often pursued during pregnancy and fixed-dose combined antituberculous agents have been found to be beneficial. Unfortunately, there is paucity of data on the safety of the fixed-dose combined antituberculous drugs during pregnancy. This study intends to assess the teratogenic effect of fixed-dose combined antituberculous drugs on the organogenesis stage of fetal development and also investigate the possible roles of vitamin C in modulating the teratogenic effects of these agents on the fetus using animal model. Pregnant rats were divided into 3 groups with 12 animals per group: group 1 received distilled water (10 mL/kg orally; group 2 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents orally; group 3 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents plus vitamin C (10 mg/kg/day orally. Six rats in each group were randomly selected and sacrificed on day 20 by cervical dislocation prior to day 21 of gestation, and the foetuses were harvested through abdominal incision for physical examination. Blood samples were collected from the 1st filial rats of the remaining six animals for biochemical and hematological examination. The liver, kidney, heart, and brain of all the sacrificed animals were used for histopathological examination. There were significant (≤0.05 low birth weights of the foetuses of the animals that were treated with fixed-dose combined antituberculous agents. The haematological parameters also revealed a reduction in the platelets counts and neutrophiles at the first filial generation. Significant (≤0.05 elevations in the levels of aspartate aminotransferase (AST and alkaline phosphatase (ALP in the foetuses of the animals treated with fixed-dose combined antituberculous agents were also observed. However, the combination of vitamin C with fixed-dose combined antituberculous agents

  1. Assessing the risk of birth defects associated with exposure to fixed-dose combined antituberculous agents during pregnancy in rats.

    Science.gov (United States)

    Awodele, O; Patrick, E B; Oluwatoyin Agbaje, Esther; Oremosu, A A; Gbotolorun, S C

    2012-01-01

    Due to the risks of disease progression and transmission to the newborn, treatment of tuberculosis is often pursued during pregnancy and fixed-dose combined antituberculous agents have been found to be beneficial. Unfortunately, there is paucity of data on the safety of the fixed-dose combined antituberculous drugs during pregnancy. This study intends to assess the teratogenic effect of fixed-dose combined antituberculous drugs on the organogenesis stage of fetal development and also investigate the possible roles of vitamin C in modulating the teratogenic effects of these agents on the fetus using animal model. Pregnant rats were divided into 3 groups with 12 animals per group: group 1 received distilled water (10 mL/kg) orally; group 2 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents orally; group 3 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents plus vitamin C (10 mg/kg/day) orally. Six rats in each group were randomly selected and sacrificed on day 20 by cervical dislocation prior to day 21 of gestation, and the foetuses were harvested through abdominal incision for physical examination. Blood samples were collected from the 1st filial rats of the remaining six animals for biochemical and hematological examination. The liver, kidney, heart, and brain of all the sacrificed animals were used for histopathological examination. There were significant (P ≤ 0.05) low birth weights of the foetuses of the animals that were treated with fixed-dose combined antituberculous agents. The haematological parameters also revealed a reduction in the platelets counts and neutrophiles at the first filial generation. Significant (P ≤ 0.05) elevations in the levels of aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in the foetuses of the animals treated with fixed-dose combined antituberculous agents were also observed. However, the combination of vitamin C with fixed-dose combined antituberculous agents significantly

  2. 2000~2010年围产儿出生缺陷监测与分析%Monitoring and analysis on birth defects of perinatal infants from 2000 to 2010

    Institute of Scientific and Technical Information of China (English)

    陈炳兰; 孙丽洲; 田静

    2013-01-01

    Objective: To understand the high risk factors of birth defects in the area by retrospectively analyzing growth and decline of birth defects in the hospital, timely find out suspicious malformation - inducing factors, and provide a basis for carrying out prevention, early diagnosis, and intervention of birth defects. Methods: According to the monitoring project of birth defect in China, the data of parturient women and perinatal infants born in the hospital from 2000 to 2010 were analyzed retrospectively. Results: From 2000 to 2010, a total of 27 838 perinatal infants were monitored, 311 perinatal infants were found with birth defects, the incidence rate was 11. 17%c. The main types of birth defects were polydactyly, congenital heart disease, cleft lip, multi - malformation, digestive tract malformation, hypospa-dias, and hydrocephalus; the incidence rate of birth defects in boys was statistically significantly higher than that in girls; the risk of birth defects among perinatal infants born by parturient women ≥ 35 years old increased significantly, especially among perinatal infants born by parturient women < 20 years old. Conclusion: Enhancing prenatal screening and prenatal diagnosis and raising prenatal detection rate of birth defects can reduce incidence rate of birth defects.%目的:通过回顾分析该院出生缺陷的消长情况,了解该地区出生缺陷的高危高发因素,及时发现可疑的致畸因素,为开展出生缺陷的预防、早期诊断和干预提供依据.方法:依照《中国出生缺陷监测方案》,对2000 ~ 2010年在该院分娩的产妇及其围产儿的资料进行统计分析.结果:11年间共监测围产儿27838例,缺陷儿311例,发生率为11.17‰;主要出生缺陷为指(趾)畸形、先天性心脏病、总唇裂、复合畸形、消化道畸形、尿道下裂、脑积水;男婴出生缺陷发生率较女婴显著增加;产母年龄≥35岁,尤其是产母年龄< 20岁时出生缺陷发生率的危险

  3. Ethical aspects of soft tissue engineering for congenital birth defects in children--what do experts in the field say?

    Science.gov (United States)

    Oerlemans, Anke J M; Rodrigues, Catarina H C M L; Verkerk, Marian A; van den Berg, Paul P; Dekkers, Wim J M

    2010-08-01

    This article is part of the EuroSTEC project, which aims at developing tissue engineering-based treatments for structural disorders present at birth. EuroSTEC is positioned at the intersection of three areas with their own ethical issues: (1) regenerative medicine, (2) research with pregnant women and fetuses, and (3) research with neonates. Because of the overlap of these three areas in this project, we can expect to be confronted with new ethical challenges. To be able to respond adequately and timely to current and possible future ethical issues, a prospective and anticipatory ethical analysis is essential. To obtain a first survey of ethical issues that might arise during the different phases of the project, the Delphi method was used. The professionals directly involved in the EuroSTEC project were questioned about their views on possible ethical issues. The first round yielded 27 ethical issues, which the respondents were asked to prioritize in the second round. For the fundamental research phase, issues deemed most important were privacy and informed consent of the tissue donor. For the animal experimentation phase, three issues were mentioned (in order of decreasing priority): the suffering of animals, the use of animals as means to an end, and the limited adequacy of the animal models. Issues that were deemed most important during the clinical (trial) phase pertained to the problem of weighing risks and benefits for the fetus/child and the pregnant woman. PMID:20163208

  4. Risk factors of birth defects in China:a Meta analysis%我国出生缺陷影响因素的M eta分析

    Institute of Scientific and Technical Information of China (English)

    万素馨; 罗亚玲; 周天津

    2015-01-01

    Objective To explore the main risk factors related to birth defects to provide the scientific basis for making the best prevention policy and implementing the effective interventions .Methods Totally 21 domestic research articles on the risk fac‐tors of birth defects were comprehensively analyzed by the meta analysis method ,including accumulated 6 112 patients and 15 741 control cases .The articles were screened preliminarily according to inclusion and exclusion standard ,and then the fixed and random effects model were selected according to the homogeneity test .The merged results were performed the chi‐square test .Results The main merged results OR values of single‐factor‐analysis were as follows:the family history of birth defects 36 .22 ,early pregnant in‐fectious disease 5 .62 ,early pregnancy exposure to chemicals 4 .19 ,paternal smoking 3 .89 ,contact sedatives during pregnancy 3 .19 , pregnancy complication 2 .94 ,high protein food during pregnancy 0 .37 ;the main merged results OR values of multiple‐factor‐analy‐sis were as follows :early pregnancy infectious disease 7 .65 ,poor prenatal mental state 5 .44 ,early pregnancy fever 4 .70 ,early preg‐nancy exposure to toxic chemical 3 .90 ,history of abortion 3 .59 ,supplement of multivitamin during pregnancy 0 .45 .Conclusion The main risk factors of birth defects in our country are family history of birth defects ,early pregnancy infectious disease ,early pregnancy exposure to chemicals ,paternal smoking and pregnancy complication;the protective factors are eating more high protein food during pregnancy ,supplement of multivitamin during pregnancy and taking folic acid during pregnancy .%目的:探讨影响我国出生缺陷发生的主要危险因素,为制定最佳预防控制决策、实行有效的干预措施提供科学依据。方法利用M eta分析方法综合分析国内关于出生缺陷发病危险因素的研究文献21篇,累计病例6112例,对照15741例。据纳

  5. 180例出生缺陷儿危险因素分析%Analysis of risk factors of birth defect in 180 cases

    Institute of Scientific and Technical Information of China (English)

    季静敏; 鲁巧珍; 何萍; 黄璧琨

    2012-01-01

    Objective To analyze the risk factors of birth defect ( BD ). Methods With case-control method 180 cases with birth defect and 180 normal newborns were selected through the medical history review. The differences in maternal age, maternal occupation, first check gestational age, medical history at early stage of pregnancy, antenatal examination times, drug use at pregnant period, pregnancy complications, history of abnormal pregnancy and delivery, family history of congenital defects, history of exposing to toxic and harmful substances, paternal age, paternal occupation and etc. Between them were analyzed. Results Univariate analysis revealed that five factors were different between case group and control group: the average age of mother ( t = 3. 255, P = 0. 001 ), the average age of father( t= 2.047, P = 0.041 ), maternal occupation(χ2= 11. 016, P =0. 026 ), history of abnormal pregnancy and delivery (χ2 =5. 767, P = 0.016), and family history of congenital defects (χ2 = 4. 405 , P = 0.044 ). Multivariate logistic analysis showed that maternal occupation ( education ) was protective factor. Conclusion BD is caused by complicated factors, including age of parents, maternal occupation, history of abnormal pregnancy and delivery and family history of congenital defects.%目的 分析引起出生缺陷儿的危险因素.方法 用病例对照的研究方法,比较分析180例出生缺陷儿(其中133例活产缺陷儿、47例引产缺陷儿)与180例出生正常儿的母亲年龄、母亲职业、初次孕检孕周、孕早期疾病史、产前检查次数、妊娠期用药、妊娠合并症并发症、异常孕产史、缺陷家族史、接触有毒有害物史、父亲年龄、父亲职业等因素的差异.结果 单因素分析显示以下5个因素在病例组和正常组之间存在显著性差异:母亲平均年龄(t=3.255,P=0.001)、父亲平均年龄(t=2.047,P=0.041)、母亲职业(χ2=11.016,P=0.026)、异常孕产史(χ2=5.767,P=0.016)

  6. 早产对脑性瘫痪儿童乳牙釉质发育的影响%The developmental enamel defects in the primary dentition of cerebral palsied children with premature birth

    Institute of Scientific and Technical Information of China (English)

    林小波; 张笋; 吴卫红; 吴志文

    2011-01-01

    目的 研究早产因素对脑瘫儿童乳牙釉质发育缺陷的影响.方法 选择135名脑瘫患儿,与62名正常儿童对比,进行乳牙釉质发育缺陷状况的统计调查.同时比较脑瘫儿童中早产与乳牙釉质发育缺陷发生的关系.结果 脑瘫儿童组中早产儿童乳牙釉质发育缺陷的患病率明显高于足月组,有统计学差异(P<0.05).结论 早产的脑瘫儿童更容易发生乳牙釉质发育缺陷.%Objective To investigate the developmental enamel defects in the primary dentition of cerebral palsied children with premature birth. Methods One hundred and thirty-five children with cerebral palsy were examined for the clinical manifestation of the developmental enamel defects in the primary dentition. The relationship between the defects and cerebral palsied children's birth conditions were assessed. Results The prevalence of enamel defects in cerebral palsied children born premarurely was significantly higher than that in those with full term birth. Conclusion Enamel defects in the primary dentition are more likely to happen in cerebral palsied children with premature birth than those with full term birth.

  7. 0~1岁婴儿出生缺陷的流行病学调查%Epidemiological survey on 0-1 years old baby with birth defect

    Institute of Scientific and Technical Information of China (English)

    倪少义; 何洁壁; 陈少娜; 吴翔; 蔡幸生; 黄伟鹏; 王榕生; 洪艳苹; 倪少英; 卢晓航

    2012-01-01

    Objective To understand the incidence of birth defect in 0-1 years old baby in some regions of Jieyang, then to determine the focus groups for prevention. So that it can provide a foundation for birth defect prevention, pre-pregnancy and pregnancy care. Methods Those babies, who were born in Jiedong County, Puning City and Rongcheng District from March 3, 2011 to May 2, 2012 were surveyed by general investigation. Birth defect based on clinical diagnosis, its entity and statistical standard referred to the regulations of International Centre on Birth Defects and Prematurity. Results 238 cases of birth defect babies were found out of 10 773 cases of monitored new babies. The top five diseases of baby birth defects were congenital heart disease, talipes equinovarus, polydactyly, cleft lip and palate and fetal-edematous-syndrome. Some babies had higher incidence of birth defects, such as baby boy, low birth weight baby, and those babies whose mother did not take folic acid, vitamin and trace elements during pregnancy and whose family members smoking and excessive drinking (P < 0.05). Conclusion The incidence rate of birth defects in 0-1 years old baby is 220.92 per ten thousand in some regions of Jieyang City. It is slightly higher than the national average, so it needs attention from each side. Strengthening propaganda and education, screening and preventing birth defects are matters of great urgency.%目的 了解揭阳部分地区0~1岁婴儿出生缺陷的发病情况,确定预防的重点人群,为出生缺陷的预防和孕前、孕期保健提供依据.方法 采用普查的方式,对揭东县、普宁市、榕城区三地2011年3月3日~2012年5月2日出生的婴儿进行调查.出生缺陷以临床诊断为依据,病种及统计标准参照国际出生缺陷监测情报交换所的规定.结果 共监测10 773名婴儿,发现出生缺陷238例;婴儿出生缺陷排名前5位的疾病分别是先天性心脏病、马蹄内翻足、多指(趾)、唇(腭)裂

  8. Relationship of Birth Defects with Electromagnetic Radiation and Food Chain%出生缺陷与电磁辐射和食物链关系分析

    Institute of Scientific and Technical Information of China (English)

    苏花莉; 夏红卫; 韦红卫; 黄卫民; 孔琳; 黄琳

    2014-01-01

    目的:探讨出生缺陷与电磁辐射和食物链的关系。方法选择195例出生缺陷患儿母亲作为研究组,195例健康儿母亲为对照组,对两组孕期居住环境及使用手机、电脑、电磁炉、微波炉频率和饮食习惯等进行调查,并检测分娩时母血雌激素、孕酮、睾酮水平。结果研究组居住靠近变压器、电视塔、通讯转播塔比例高于对照组(P均<0.05),孕期食用人工饲料喂养的家禽、牲畜、鱼等的频率高于对照组(P均<0.05);研究组孕期使用手机、电脑、电磁炉、微波炉、观看电视的频率高于对照组( P均<0.05)。结论电磁辐射和食用人工饲料喂养的家禽、牲畜、鱼类等肉食对出生缺陷可能有影响。%Objective To investigate the relationship of birth defects with electromagnetic radiation and food chain.Methods One hundred and ninety-five mothers who had infants with birth defects were selected as study group ,and 195 mothers who had healthy infants were selected as control group .An investigation was conducted on the aspects of living environment ,the frequency of using mobile phone ,computer ,electromagnetic oven or microwave oven , and diet habit during pregnant period .The levels of estrogen ,gestagen and testosterone in maternal blood were detected after delivery .Results The mothers in the study group living near the electric transformer ,TV tower or communication transmission tower were more than those in the control group (all P<0.05),the frequencies of mothers′eating artificial feeding fowl,livestock or fish during pregnant period of study group were higher those of control group (all P<0.05). The frequencies of mothers′using mobile phone ,computer ,electromagnetic oven ,microwave oven or watching TV during pregnant period of study group were higher than those of control group (all P<0.05).Conclusion Electromagnetic radiation and eating artificial feeding fowl ,livestock and

  9. Relationship of Birth Defects with Electromagnetic Radiation and Food Chain%出生缺陷与电磁辐射和食物链关系分析

    Institute of Scientific and Technical Information of China (English)

    苏花莉; 夏红卫; 韦红卫; 黄卫民; 孔琳; 黄琳

    2014-01-01

    Objective To investigate the relationship of birth defects with electromagnetic radiation and food chain.Methods One hundred and ninety-five mothers who had infants with birth defects were selected as study group ,and 195 mothers who had healthy infants were selected as control group .An investigation was conducted on the aspects of living environment ,the frequency of using mobile phone ,computer ,electromagnetic oven or microwave oven , and diet habit during pregnant period .The levels of estrogen ,gestagen and testosterone in maternal blood were detected after delivery .Results The mothers in the study group living near the electric transformer ,TV tower or communication transmission tower were more than those in the control group (all P<0.05),the frequencies of mothers′eating artificial feeding fowl,livestock or fish during pregnant period of study group were higher those of control group (all P<0.05). The frequencies of mothers′using mobile phone ,computer ,electromagnetic oven ,microwave oven or watching TV during pregnant period of study group were higher than those of control group (all P<0.05).Conclusion Electromagnetic radiation and eating artificial feeding fowl ,livestock and fish might have influence on birth defects .%目的:探讨出生缺陷与电磁辐射和食物链的关系。方法选择195例出生缺陷患儿母亲作为研究组,195例健康儿母亲为对照组,对两组孕期居住环境及使用手机、电脑、电磁炉、微波炉频率和饮食习惯等进行调查,并检测分娩时母血雌激素、孕酮、睾酮水平。结果研究组居住靠近变压器、电视塔、通讯转播塔比例高于对照组(P均<0.05),孕期食用人工饲料喂养的家禽、牲畜、鱼等的频率高于对照组(P均<0.05);研究组孕期使用手机、电脑、电磁炉、微波炉、观看电视的频率高于对照组( P均<0.05)。结论电磁辐射和食用人工饲料喂养的家禽、牲畜、鱼类

  10. Case-control study on influencing factors of perinatal birth defects%围产儿出生缺陷影响因素的病例对照研究

    Institute of Scientific and Technical Information of China (English)

    李媛媛; 张海鲲; 李忠良; 翟庆峰

    2011-01-01

    目的 探寻围产儿出生缺陷的影响因素,为出生缺陷干预提供科学依据.方法 按照1:1配对的原则选取出生缺陷围产儿和健康围产儿各807例,用单因素与多因素Logistic回归分析筛选出生缺陷的主要影响因素.结果 婚前参加体检,经常食用鱼虾肉蛋类、牛奶豆类食物等为出生缺陷的保护性因素;父母近亲结婚、家庭附近有污染、孕育期用药、孕育期接触有害物质、有生育畸形儿史、母亲吸烟饮酒为出生缺陷的危险因素.结论 出生缺陷干预可从控制环境有害因素、加强孕期营养保健、指导孕期合理用药、减少吸烟饮酒等不良行为生活方式、提倡婚前体检等方面综合入手.%Objective; To explore the influencing factors of perinatal birth defect. Methods; According to the birth date and sex matching principle, selected 807 perinatal birth defects infants and 807 normal infants. The influencing factors of perinatal birth defect were filtered with the Logistic regression analysis. Results: Regular intake of fish, shrimp, meat, eggs, milk, and beans during pregnancy , participating in pre-marital medical examination were the protective factors of birth defects. Consanguineous marriage, environment pollution sources near residence, suffering from chronic diseases before or during pregnancy, maternal exposure to occupational risk factors before or during pregnancy, abnormal reproductive history, and the habit of drinking and smoking were the risk factors of birth defects. Conclusion; To reduce infant birth defect incidence and improve national body diathesis, we must protect from environment risk factors, enhance pregnant nutrition, quit smoking and drinking, and advocate the premarital examination.

  11. How Suitable Are Registry Data for Recurrence Risk Calculations?

    DEFF Research Database (Denmark)

    Ellesøe, Sabrina Gade; Jensen, Anders Boeck; Ängquist, Lars Henrik;

    2016-01-01

    BACKGROUND: Congenital heart disease (CHD) occurs in approximately 1% of all live births, and 3% to 8% of these have until now been considered familial cases, defined as the occurrence of two or more affected individuals in a family. The validity of CHD diagnoses in Danish administrative registry...... identifier in the Danish registries, thus enabling connection of information from several registries. Utilizing the CPR number, we identified Danish patients with familial CHD and reviewed each patient's file. We compared diagnoses from the registries with those manually assigned, which enabled calculation...... of nine of all cases with CHD are familial, and we also found that 36% of individuals with CHD in administrative medical registries are misclassified, which distort the RRR in simulated scenarios....

  12. What are cancer registries

    Directory of Open Access Journals (Sweden)

    Miladinov-Mikov Marica

    2004-01-01

    Full Text Available Introduction Population-based cancer registries attempt to collect, process, analyze, store and interpret data on persons with cancer in a certain population (most frequently a geographical area. Hospital-based cancer registries register all cases in a given hospital, usually without knowledge of the background population; the emphasis is to serve the needs of the hospital administration, the hospital cancer program, and, above all, the individual patient. History of Cancer Registries Registration of persons suffering from cancer is a slow process. Around the year 1900, England and Germany demanded improvement of statistical investigation on spread of cancer in population in order to undertake etiological researches. The oldest example of a modern cancer registry is that in Hamburg. Today there are more than 200 population-based cancer registries, but they cover only 5% of the world population, mainly in developed countries of the world. Cancer registry of Vojvodina Cancer registry of Vojvodina was established in 1966; it is a member of International Agency for Research on Cancer (IARC and it is still the only cancer registry from our country whose data are cited in scientific monographs of IARC. The main purpose of cancer registries is to produce statistics on the occurrence of cancer in a defined populatin and to provide a framework for assessing and controlling the impact of cancer on the community. Cancer registries are essential parts of any rational program of cancer control. Their data can be used in a wide variety of areas of cancer control, ranging from etiological research in epidemiology, through primary and secondary prevention to health-care planning and patient care, so benefiting both the individual and society.

  13. 孝感市2007~2011年围产儿出生缺陷流行病学调查%Study on perinatal birth defects from 2007 to 2011 in Xiaogan City

    Institute of Scientific and Technical Information of China (English)

    邱越; 陆敏; 杨树杰; 刘景丽; 付汉东; 彭红华; 李君; 罗红英; 余小艳

    2013-01-01

    OBJECTIVE To master the epidemiology of birth defect in Xiaogan City,analysis the dynamic trends and try to find out the main factors that may affect birth defects so as to develop effective preventive measures to improve the quality of newborn births.METHODS All the perinatal birth defects monitoring data of year 2007-2011 that in all the midwifery unit of Xiaogan were collected by child birth defects registration card and analyzed retrospectively.RESULTS Five-year birth defects incidence was 4.26‰ and the rates among the 5 years had no statistic difference (P> 0.05).The common birth defects in the top five were multi-finger polydactyly (0.61‰),external ear malformation (0.47‰),cleft lip with cleft palate (0.45‰),cleft lip (0.39‰) and congenital heart disease (0.32‰).Prenatal diagnosis rate was 21.08%,of which B-ultrasound diagnosis was 14.46%.Age of the maternal was a factor to birth defects that when the mother was older than 35 or younger than 20 the incidence of birth defects was obviously higher than other age group.Male birth defects rate were higher than females.The defects rate in countries was higher than that in towns.There was a positive relationship between the maternal education level or lower household income and rate of perinatal birth defects.CONCLUSION The main birth defects in Xiaogan of the last five years are the surface defects and the high risk factor of the birth defects are mother age,education level,economic level and place of residence.The rural areas are the focus to make prevention.So we should strengthen promotion of marriage and pregnancy health and improve prenatal diagnostic techniques so as to reduce the incidence of birth defects effectively.%目的 掌握孝感市围产儿出生缺陷的流行病学特征,分析主要出生缺陷的高危因素,制定有效的预防措施,提高出生人口的素质.方法 采用《出生缺陷儿登记卡》收集孝感市所有助产技术单位2007~2011年围产儿出生

  14. Understanding optimal nutrition among women of childbearing age in the United States and Puerto Rico: employing formative research to lay the foundation for national birth defects prevention campaigns.

    Science.gov (United States)

    Lindsey, Lisa L Massi; Hamner, Heather C; Prue, Christine E; Flores, Alina L; Valencia, Diana; Correa-Sierra, Elia; Kopfman, Jenifer E

    2007-12-01

    Neural tube defects (NTDs) are serious birth defects of the brain and spine that affect approximately 3,000 pregnancies in the United States each year and affected 404 pregnancies in Puerto Rico from 1996 to 2002. Consuming the B vitamin folic acid can reduce the incidence of NTDs 50%-70%, and recent efforts to reduce NTD rates have focused on increasing the number of childbearing-aged women who take a vitamin containing folic acid every day. As the first stage of formative research in campaign planning, two exploratory, qualitative studies were conducted in order to (a) understand the complexity of vitamin use among women in the United States and Puerto Rico and (b) serve as a foundation on which to develop national communication and education interventions. Also, this information shed light on theories that might be used to guide campaign development. Results indicated that campaign messages designed to increase folic acid use through multivitamin supplementation in the United States must address women's barriers to vitamin use (e.g., cost, time), increase women's perceived need for multivitamins (e.g., identify immediate, tangible results from taking a daily multivitamin), and address the relationship between daily food choices and the need for supplementation. Future campaign messages in Puerto Rico must focus on many of these same issues, in addition to increasing women's knowledge about when folic acid should be taken in relation to pregnancy and addressing women's perceptions that vitamins cause weight gain (an undesirable outcome for most participants). The practical and theoretical implications of these results are discussed in terms of their contribution to the development of a creative new approach to increase multivitamin consumption among women of childbearing age in the United States and Puerto Rico. PMID:18030639

  15. Paper 6: EUROCAT member registries: organization and activities

    DEFF Research Database (Denmark)

    Greenlees, Ruth; Neville, Amanda; Addor, Marie-Claude;

    2011-01-01

    EUROCAT is a network of population-based congenital anomaly registries providing standardized epidemiologic information on congenital anomalies in Europe. There are three types of EUROCAT membership: full, associate, or affiliate. Full member registries send individual records of all congenital...... anomalies covered by their region. Associate members transmit aggregate case counts for each EUROCAT anomaly subgroup by year and by type of birth. This article describes the organization and activities of each of the current 29 full member and 6 associate member registries of EUROCAT....

  16. 肇庆市2001-2010年围产儿出生缺陷监测资料分析%Data analysis of perinatal and infants with birth defects from 2001 to 2010 in Zhaoqing county

    Institute of Scientific and Technical Information of China (English)

    陈志玮; 刘楚芹; 梁云

    2012-01-01

    Objective To find out the incidence of birth defects and its variation in four hospitals of Zhaoqing, and to investigate the risk factors that causing birth defects, in order to provide references for formulating intervention measures. Methods According to the requirements of "Monitoring planning of birth defects in hospitals of Guangdong province", four hospitals in Zhaoqing were chosen for this investigation, and statistical analysis methods were used to analyze the birth defects data from 2001 to 2010 in Zhaoqing. Results 63 476 perinatal and infants were observed from 2001 to 2010, and 1 043 infants were found to have birth defects, and the incidence was 162.9 per ten thousand. There was an upward trend in general, and the incidence in 2010 was significantly higher than that in 2001 (χ2=21.635,P<0.001). The top three types of birth defects were congenital heart disease, fetal edema syndrome, and polydactyly malformation. Incidence of birth defect was associated with the sex, maternal age, and fetus number. Conclusion Birth defects have a great impact on the quality of the population, and the third class preventive measure should be continually strengthened to reduce the birth defects.%目的 了解肇庆市4家监测医院出生缺陷儿的发生率及其变化情况,研究出生缺陷发生的相关因素,为制定出生缺陷干预措施提供依据.方法 按照《广东省出生缺陷医院监测方案》的要求,以市内4家医院作为监测医院,对肇庆市2001-2010年的出生缺陷监测资料进行回顾性分析.结果 2001-2010年共监测围产儿63476名,其中出生缺陷儿1 034名,发生率为162.90/万,总体呈上升趋势,2010年的发生率比2001年高,差异有统计学意义(x2=21.635,P<0.001).前3位出生缺陷类型依次为先天性心脏病、胎儿水肿综合征、多指(趾)畸形.出生缺陷发生率与围产儿性别、孕母年龄、胎数有关.结论 出生缺陷严重影响出生人口的素质,应继续加强三

  17. Analysis on the Changes of Incidence Rates on Birth Defects in Yidu City during 2007-2011%宜都市2007-2011年出生缺陷发生趋势分析

    Institute of Scientific and Technical Information of China (English)

    曹方兰

    2013-01-01

    目的:调查笔者所在市出生缺陷发生情况,了解出生缺陷变化趋势,为制定干预措施提供依据。方法:对笔者所在市2007-2011年各监测医院上报的《出生缺陷报告卡》进行回顾性总结分析。结果:出生缺陷发生率呈下降趋,五年平均出生缺陷发生率10.57‰。其中肢体缺陷发生率3.97‰,居第一位;唇腭裂发生率1.55‰,居第二位;外耳畸形发生率1.4‰,居第三位。结论:开展婚前保健、增补叶酸、孕前保健、孕期保健、产前筛查、产前诊断和终止妊娠等干预措施,降低出生缺陷发生率。%Objective:To investigate the birth defects in this city,to acquaintance the trend of birth defects and provide evidence for the intervention measures.Method:To retrospectively analyze“birth defects report card”reported by each monitoring hospital in 2007-2011.Result:The incidence of birth defects was declined,the average defect rate was 10.57‰.The incidence rate of limb defects reached 3.97‰,ranking the first;the incidence rate of cleft lip and palate defects reached 1.55‰,ranking the second;the incidence rate of ear malformation reached 1.4‰,ranking the third.Conclusion:To reduce the incidence of birth defects by intervention measures such as premarital care,folic acid,preconception care,prenatal care,prenatal screening,prenatal diagnosis and termination of pregnancy.

  18. 不同户籍类型出生缺陷监测分析与干预措施的研究%The analysis and interventions research for different census types of birth defects

    Institute of Scientific and Technical Information of China (English)

    马健; 朱丹玲; 何慧芳; 张清; 王莉平

    2011-01-01

    Objective; To know different types of prenatal incidence of birth defects in children and their tendency, and to realize outcome of children with birth defects, common types of birth defects and changes in Futian District, Shenzhen, which would provide the basis for developing interventions. Metheds: Birth defects and prenatal child death observation data from 2003 to 2007 were analyzed in retrospectively. Results; The incidence of birth defects is on an upward trend (x2 = 23. 52, P = 0. 001) , for the most part, incidence of birth defects came from the floating population (x2 = 23. 70, P = 0. 001). The average birth defect rate in the 7 years was 21. 74 ‰, the residence rate was 20. 80 ‰, temporary rate was 20. 50 ‰, floating population rate was 23. 38 ‰, residence and temporary residents of birth defects rate was significantly lower than the floating population, the difference was significant (x2 = 11.91, P= 0.003). Residence, temporary, and floating population, compose the birth defect death rate of 2. 95‰, 3. 74‰, 6.42‰; the difference was significant (x2 = 69. 35, P<0. 001). The top six of birth defects is; congenital heart disease, multiple fingers (toes) , total cleft lip and palate, ear deformities, clubfoot, and hypospadias. These account for 59. 07% of the birth defects. Conclusion; The floating population in maternal health care system for the management of pregnant women in Shenzhen City, which is a bottleneck problem; the proposed solution for maternal and child health services is to make it equal, by establishing "to introduction the free prenatal care and postpartum visits project in Futian District, Shenzhen" , to improve the creating card rate of early pregnancy women in floating population and the rate of system management, in order to promote detection of birth defects, particularly to improve the pregnancy early and mid - term detection rate of birth defects and diagnosis rates. To reduce birth defects and prenatal child

  19. 重庆市涪陵区311例围生儿出生缺陷分析%Birth defects analysis of 311 perinatal infants at Fuling district in Chongqing

    Institute of Scientific and Technical Information of China (English)

    刘明会; 薛莹; 李红

    2015-01-01

    Objective To investigate the current status and change tendency of birth defects in the region to provide ref-erence for formulating reasonable prevention measures against birth defect. Methods A total of 311 monitoring data of birth de-fect from the hospitals including Fuling Central Hospital ,Puling Women and Children Health Care Hospital and Puling People′s Hospital from October 1,2010 to September 30,2013 at Fuling district in Chongqing were analyzed retrospectively,understanding the occurrence of birth defect,defect rate change trend as well as the related factors and birth defects (defects gender,age,residence and education level of lying-in women,etc.). Results Birth defect rate from the three monitoring organs of this region was de-creased annually. The occurrence of birth defects in 2013,accoutning for 1.846%(120/6 501),was significantly lower than that 2.046%(88/4 301) in 2011,whose difference had statistically significance(P0.05). The incidence of birth defect of the women aged less than 20 years old or over 35 years old were both higher than that of the women aged 20-35 years old. The lying-in women graduated from junior middle school or below had a higher occurrence in birth defect,and the difference had statistical significance(P<0.05). The prenatal diagnosis of birth defects,with the diagnostic rate of 21.54%(63/311) only,gave priority of ultrasonic diagnosis and chromo-some examination . Conclusion Paying attention to the occurrence of relevant factors of birth defect and improving the prenatal diagnosis of birth defects rate may effectively reduce the incidence of birth defect.%目的:探讨重庆市涪陵区出生缺陷儿的现状和变化趋势,为制订适合当地出生缺陷防治措施提供参考。方法选取该地区涪陵中心医院、涪陵区妇幼保健院、涪陵区人民医院3家监测机构2010年10月1日至2013年9月30日分娩的311例出生缺陷儿监测资料进行回顾性分析,了解出生缺陷发生率的

  20. Mortalidad por defectos al nacimiento en menores de 5 años de edad en México de 1998 a 2006 Birth defects mortality in five-year-old minors of age, Mexico, 1998-2006

    Directory of Open Access Journals (Sweden)

    Javier Valdés-Hernández

    2009-10-01

    Full Text Available OBJETIVOS: Analizar la mortalidad por defectos al nacimiento (DAN entre 1998 y 2006. Seleccionar los municipios con alta mortalidad en OBJECTIVE: To analyze mortality due to birth defects from 1998-2006. To select municipalities with high mortality among children under 5 years of age. MATERIAL AND METHODS: The source of information was mortality records from vital statistics collected by SSA/INEGI. We used the 2005 Municipal Geostatistical Framework by INEGI and SIGEPI for the spatial analysis. The selection criteria were municipalities with 80% and over of deaths due to birth defects. RESULTS: Deaths diminished 8% during 1998-2006 and rates decreased 20%. A total of 42.57% - 48% of deaths are due to circulatory system defects and 13.69% - 19.39% are due to the nervous system; the former rose 4% and the latter fell 32%. Eighty percent or more occur in children under 5 years and the rate in this group fell 8.63%. A total of 1 025 (41.82% municipalities are priorities, 104 (10.14% are high and 102 (9.95% are very high priorities, where 66% of deaths occur among children under 5 years old. DISCUSSION: The interventions to decrease mortality due to birth defects should be directed towards one-year-old children (75% and towards 8.4% of the municipalities that are a very high priority, since they represent 66% of the deaths.

  1. Relating Factors and Effects of Intervention on Birth Defects in Zhuhai City%珠海市围产儿出生缺陷危险因素及干预措施研究

    Institute of Scientific and Technical Information of China (English)

    张燕; 金正平; 戚小兵; 赵静; 胡翀; 张红忠; 曾淑萍; 李文典; 梁雄; 谭晓燕; 黄辉文

    2012-01-01

    Objectives To find out the status of birth defects and the relating factors in Zhuhai city, to valuate the effect of the measures of integrated intervention and to provide evidence for intervention measures and decisions-making. Methods Data was collected from the Zhuhai birth defects surveillance system from 2007 to 2010. And a case-control study was carried out on congenital malformations to evaluate the risk factor and the effect of the measures of integrative intervention. Results The incidence of birth defects reduced after the integrative intervention, top birth defects ranking changed, the incidence of NTD reduced. The main risk factors of congenital malformations were the history of abortion, times of abortion, exposure to chemical substances before or during pregnancy, the history of birth defect, the father's smoking history, maternal malnutrition during pregnancy, and maternal bad feelings during pregnancy. Conclusions Some risk factors were identified as having important effect on preinstall congenital malformations. Taking serial integrative intervention measures and strengthening three-level prevention will be beneficial to the reduction of birth defects.%目的 调查珠海市围产儿出生缺陷的发生情况,了解围产儿出生缺陷发生的危险因素,为围产儿出生缺陷的预防和干预提供依据.方法 收集珠海市2006~2010年出生缺陷资料,对先天畸形儿的双亲进行了病例对照研究,调查其危险因素,并对其综合干预措施的效果进行对比评估.结果 干预后,珠海市出生缺陷发生率下降,出生缺陷顺位及构成发生变化,神经管畸形发生率降低.出生缺陷的主要影响因素有:流产史及流产次数、孕期接触化学制剂、生产畸胎史、父亲吸烟史、母亲孕期营养不良、母亲孕期情绪不良.结论 影响出生缺陷的相关危险因素较多,降低出生缺陷发生率,应建立多种形式的综合措施,做好三级预防工作.

  2. 佛山市2007~2009年围产儿出生缺陷监测分析%Analysis on surveillance of birth defects among perinatal infants of Foshan city from 2007 to 2009

    Institute of Scientific and Technical Information of China (English)

    贾德勤; 王星; 伍捷阳; 吴雪丽

    2011-01-01

    目的了解佛山市2007~2009年围产儿出生缺陷发生状况和变化趋势,分析影响其出生缺陷发生的危险因素.方法 对2007~2009年在广东省佛山市妇幼保健院接受产前检查和(或)住院分娩的孕期满28周至产后7 d内的围产儿18 073例进行出生缺陷及相关因素的监测.结果 (1)3年来围产儿出生缺陷率为608.09/万,呈逐年上升的趋势.(2)出生缺陷前5位依次为先天性心脏病、葡萄糖-6-磷酸脱氢酶缺陷症、外耳其他畸形、多指(趾)、α-地中海贫血.上述几种缺陷的发生率均明显高于全国平均水平.(3)出生缺陷发生的性别差异明显,男性高于女性.(4)孕母大于或等于30岁是出生缺陷的高发年龄段,尤其是大于或等于35岁组出生缺陷发生率明显高于其他各年龄组.(5)出生缺陷围产儿死亡率为141.04‰.结论 出生缺陷发生率逐年上升,应积极开展婚前医学检查,提高产前诊断水平,及时进行新生儿疾病筛查,提高人口素质.%Objective To understand the incidence of the birth defects and variation tendency from 2007 to 2009 in foshan,and to analyse the risk factor which influence the incidence of birth defects. Methods The birth defects and its relevant factor of 18 073 perinatal neonates(dated from 2007 to 2009)were monitored. Results (1)In recent 3 years the average detection rate of birth defects was 608.09/10 000,which showed an increasing tendency year by year. (2)Top five birth defects were congenital heart disease, glucose-6-phosphate dehydrogenase deficiency, deformity of external ear, polydactyly fingers, α-thalassemia. (3) The incidence of these defects were significantly higher than the nationwide average. (4)The occurrence of birth defects was higher in male than that in female according to the sex distribution. (5)Pregnant female over 30 years old was higher outbreak age group, especially more than 35 years. (5)The mortality of birth defects was 141.04‰. Conclusion

  3. Data Element Registry Services

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data Element Registry Services (DERS) is a resource for information about value lists (aka code sets / pick lists), data dictionaries, data elements, and EPA data...

  4. Trauma registry reengineered.

    Science.gov (United States)

    Wargo, Christina; Bolig, Nicole; Hixson, Heather; McWilliams, Nate; Rummerfield, Heather; Stratton, Elaine; Woodruff, Tracy

    2014-01-01

    A successful trauma registry balances accuracy of abstraction and timeliness of case submissions to achieve quality performance. Staffing to achieve quality performance is a challenge at times based on competitive institutional need. The aim of this performance improvement timing study was to identify trauma registry job responsibilities and redesign the responsibilities to create increased abstraction time and maintain accuracy of data abstraction. The outcome is measured by case submission rates with existing staffing and interrater reliability outcomes. PMID:25397337

  5. 宁波市2010年度出生缺陷危险因素调查及干预效果评价%Risk Factors of Birth Defects and Evaluation of Effect of Intervention Measures

    Institute of Scientific and Technical Information of China (English)

    邹鸣飞; 孙跃宏; 屈煜; 钱莹莹; 蒋燕萍; 舒立波

    2012-01-01

    Objective To investigate the birth defect monitoring of residents of Ningbo in 2010 and to analyze the birth defects incidence, risk factors, intervention measures and its effect in order to seek effective measures to reduce the incidence of birth defects. Methods 693 birth defects cases who were 28 weeks after pregnancy to 1 week after delivery from all levels hospital in Ningbo were selected as observation group, and 585 subjects without birth defects were selected as control group. Risk factors of birth defects and intervention measures were compared between the two groups. Results There were 211 cases having risk factors in birth defect group, accounting for 30. 45% . There were 142 cases having risk factors in control group, accounting for 24. 27%. Exposing rate of risk factors like chemical risk factors and physical risk factors showed statistically significant differences between the two groups ( P 0. 05 ) . While participation of premarital physical examination, TORCH testing, intake of folic acid three months before pregnancy and three months after the pregnancy showed statistically significant difference ( P < 0. 05 ) . Conclusion A-voidance of chemical or physical risk factors, participation of premarital physical examination, TORCH testing and intake of folic acid three months before pregnancy and three months after the pregnancy can effectively reduce the incidence of birth defects.%目的 调查宁波市2010年度出生缺陷监测实况,分析宁波市出生缺陷发生情况、危险因素与干预措施及其效果,寻求降低出生缺陷发生率的有效措施.方法 随机抽取2010年度宁波市在各级各类医疗保健机构内住院分娩的妊娠满28周至产后1周的出生缺陷围生儿693例为观察组,同期随机抽取无出生缺陷围生儿585例为对照组,对两组进行致出生缺陷危险因素及干预措施比较分析.结果 出生缺陷组有危险因素的围生儿211例,占30.45%;对照

  6. The relationship between folate metabolism Related Gene and Birth Defects, Poor Pregnancy%叶酸代谢基因与出生缺陷和不良妊娠的关系

    Institute of Scientific and Technical Information of China (English)

    刘英华; 陈瑛

    2012-01-01

    More and more study shown that folate had important role in the birth defects such as congenital heart disease and neural tube defects, adverse pregnancy such as premature birth and abortion. However, promotion " folic acid fortification" will artificially lead to future population dependent on a large number of vitamin, lead to the overall gene composition changed, the crowd will become very fragile to a fatal disease, folate level in whose is lower than that in normal persons. Maternal folate deficiency may result in general impairment of fetal growth, which is reflected in low birth weight. Such women also have a high incidence of abortion, ab-ruptio placentae and fetal malformation. Folate supplemented in pregnant women with the appropriate dose can reduce the risk of diseases such as birth defects and adverse pregnancy. In this article, we discussed the relationship between polymorphisms of enzyme genes involving folate metabolism and risk of birth defects such as congenital heart disease and neural tube defects, adverse pregnancy such as premature birth and abortion.%叶酸在先天性心脏病、神经管畸形等出生缺陷和早产、流产等不良妊娠中的作用越来越受到关注.然而,研究表明推广“叶酸强化”将人为地导致未来的人口对于大量的维生素产生依赖性,导致人口整体的基因组发生变化,这种人群对于某种致命的疾病将变得十分脆弱,患者体内的叶酸水平低于正常个体,产妇叶酸缺乏会因产生低出生体重的胎儿而损害胎儿的生长,另外还有流产、胎儿畸形和胎盘早剥等高发病率的风险.孕妇在妊娠前和妊娠期补充适量的叶酸可降低出生缺陷、不良妊娠等疾病的发生概率.因此,本研究就近几年国内外关于叶酸代谢相关酶基因多态性和先天性心脏病、神经管畸形等出生缺陷和早产、流产等不良妊娠关系进行简要综述.

  7. Analysis of birth defects supervision in obstetrical hospitals in Beijing Haidian District%北京市海淀区产科医院出生缺陷监测分析

    Institute of Scientific and Technical Information of China (English)

    钟赋真; 张雪峰; 周钰

    2012-01-01

    Objective To understand the incidence of birth defects in hospitals in Haidian District during recent years so as to provide management clue for supervision in the future. Methods From October 1 of 2006 to September 30 of 2010, fetus and newborns between 13 gestational weeks and 7d after delivery were supervised for birth defects in hospitals of Haidian district, and the supervision results were analyzed in terms of rate and cis position. Results There were 3 776 defected cases including 2 861 cases in perinatal period ( the incidence rate of birth defects in perinatal period was 17. 98‰ ) and 906 cases induced to abortion in second trimester. In floating population the incidence rate of birth defects showed a rising trend in perinatal period during these years( x2 =52. 250, P = 0. 000 ). The first five highest rates of birth defects were congenital heart disease, deformity of external ear, multi finger ( toe ), merged finger ( toe ) and hypospadias in order. The trend of neural tube defects rate was stable and the incidence of cleft lip dropped obviously. But the incidence of Trisomy 21 rose gradually, and there was no significant difference (x2 =6. 906, P =0. 075 ). Conclusion The incidence rate of birth defects is 17. 98‰ in hospitals of Haidian district, and the trend of birth defects rate is rising during 2006-2010 year especially in floating population. The primary prevention of folic acid supplement should be strengthened.%目的 了解近年来北京市海淀区医院出生缺陷的发生情况,为今后监测工作的管理重点提供依据.方法 对2006年10月1日至2010年9月30日期间北京市海淀区产科医院孕13周~产后7天的胎儿及新生儿进行出生缺陷监测,并对监测结果进行率及顺位等分析.结果 ①监测到出生缺陷儿3 776例,其中围产期2 861例(围产期出生缺陷儿发生率为17.98‰),中孕引产906例;②2006至2010年,外地户籍围产期出生缺陷发生率呈逐年上升的趋势(χ2

  8. Changing trend in congenital abdominal wall defects in Eastern region of Ireland.

    LENUS (Irish Health Repository)

    McDonnell, R

    2002-09-01

    In the past six years, there have been reports from abroad of an unexplained rise in the birth prevalence rate of the congenital abdominal wall defect gastroschisis, while rates for the macroscopically similar anomaly omphalocoele have remained stable. The Dublin EUROCAT Registry of congenital anomalies monitors trends in the birth prevalence of birth defects in the eastern region of Ireland. We analysed births of children with omphalocoele and gastroschisis born in the period 1981-2000, with comparisons of a number of demographic and obstetric variables. During the 20 year period the birth prevalence rate for omphalocoele remained stable at 2.5\\/10,000 births, whereas the rate for gastroschisis increased significantly during the 1990s from 1.0\\/10,000 in 1991 to 4.9\\/10,000 in 2000. Most of the increase occurred among mothers under 25 years of age. Omphalocoele was associated with a relatively high proportion of other major congenital anomalies. This study showed that there has been an unexpected rise in the birth prevalence of gastroschisis in the region, similar to that experienced in other countries in the same time period and likely to have common aetiological features.

  9. 超声检查在出生缺陷预防中的应用%Ultrasonographic examination for prevention of fetal birth defect

    Institute of Scientific and Technical Information of China (English)

    Keong WONG

    2009-01-01

    During pregnancy, a unique and dramatic sequence of events occurs, defining the most remarkable transformation of a single cell into a recognizable human being. Uhrasonographic examination is play a important role for prevention of fetal birth defect. For some years, there have been dramatic advances in ultrasound technology, including improved spatial and contrast resolution, three-dimensionaland four-dimenstional imaging, harmonic imaging, new and improved ultrasound sanning probes, and improved digital review workstations, to name a few. Likewise, our knowledge of normal fetal anatomy and pathology, and the pathophysiology of disease have increased substantially. The internet has made communication among researcheres earier. There have been many collaborative studies and refinements of the guidelines for the performance of the obstetric ultrasound examination. But there are still some differences in the approach to the obstetric ultrasound examination from one group to the others. Some issues such as what constitutes a basic ultrasound examination, what structure should be perform and interpret the examination, how safe is ultrasound, how should it be recorded and documented, how should it be reported,and how accurate rate of diagnosis fetal congenital malformation. In conclusion is that, the appeal of the ultrasound examination is that it is a noninvasive, safe procedure that has a high degree of patient acceptance and can yield a wealth of information. It is always a delight to examine the obstetric patient and reassure her about her pregnancy, when appropriate. However, there are times when an abnormality is strongly suspected but it may be equivoal or may not fit into a specific category. Under these circumstances, the best pathway for the sonologist to is to do a follow-up examination and seek consultation. If time does not allow a follow-up examination, then the sonologist should communicate to the referring physician and the patient that a definiitve

  10. 昌吉州2005至2010年486例出生缺陷分析%Analysis of birth defects of 486 cases in 2005-2010 in Changji

    Institute of Scientific and Technical Information of China (English)

    陈筱萍; 李冬梅; 马彦华

    2011-01-01

    Objective To investigate the incidence of birth defects and related factors in Changji so as to provide some basis for working out preventive measures for birth defects. Methods A retrospective study was conducted to analyze the data of 486 cases of birth defects collected from each hospital in Changji from 2005 to 2010. Results The incidence of birth defects increased year by year from 2005 to 2010, and it increased in 2010 ( 10. 67‰ ) by 5. 61% compared with that in 2005 ( 5. 06 ‰). The incidence of birth defects when pregnant women were over 35 years and over 40 years was 8. 28% ‰ and 10. 67‰ respectively. The sequence of birth defects was neural tube defects, cleft lip and palate, polydactyly, congenital hydrocephalus, congenital heart disease and talipes equinovarus in order. Conclusion The advanced ages and rural areas are the focus of prevention work. Strengthening propaganda on prenatal and postnatal care, enhancing system management during pregnancy, taking low-dose folic acid tablets before pregnancy and at early pregnancy and improving prenatal diagnostic technique are the effective measures to reduce the incidence of birth defects.%目的 了解昌吉州出生缺陷发生情况及相关因素,为制订预防出生缺陷的措施提供依据.方法 收集昌吉州辖区内各家医院2005至2010年间出生的486例缺陷儿的资料,进行回顾性分析.结果 2005至2010年出生缺陷发生率呈逐年上升趋势,2005年(5.06‰)与2010年(10.67‰)相比上升了5.61‰;年龄大于35、40岁以上妊娠者缺陷发生率分别为8.28‰、10.67‰;出生缺陷的顺位依次为神经管畸形、唇腭裂、多指趾、先天性脑积水、先心病、马蹄内翻.结论 高龄孕妇、农村地区是出生缺陷工作预防的重点,加强优生优育宣传,加强孕期系统管理,在孕前、孕早期服用小剂量叶酸片,提高产前诊断技术,是降低出生缺陷发生率的有效措施.

  11. 2010-2014年勐腊县出生缺陷发生现状及结果分析%The status of birth defects and result analysis in mengla county from 2010 to 2014

    Institute of Scientific and Technical Information of China (English)

    孙兰英; 依彦光; 胡亚君

    2015-01-01

    目的:调查2010-2014年勐腊县出生缺陷的发生情况,探讨出生缺陷发生的相关因素,提出干预措施。方法:监测勐腊县6家医院住院分娩情况。孕28周至产后7 d内围产儿逐一筛查,并填写出生缺陷儿登记卡。结果:11442例围产儿中,出生缺陷38例(3.32‰)。出生缺陷死亡16例(421.05‰),其中农村4.67‰,城市1.59‰(χ2=1.92,P<0.05)。出生缺陷前5位是多、并指(趾),先心病,α-地中海贫血,唐氏综合症,神经管畸形。结论:勐腊县是少数民族居住地区,经济、文化、医疗技术落后,为此应加强健康教育、婚前检查、孕前保健、产前检查和产前诊断,降低出生缺陷,提高人口素质。%Objective:To investigate the occurrence of birth defects in mengla county from 2010 to 2014,to explore the factors related to the incidence of birth defects,and to propose interventions.Methods:Labor conditions were monitored in 6 hospitals of mengla county.We made detailed screening for perinatal fetus from 28 weeks of gestation to 7 days after postpartum,and filled in birth defects registration card.Results:In 11 442 cases of perinatal fetus,38 cases(3.32‰) had birth defects,16 cases died because of birth defects(421.05‰ ),the rural was 4.67‰ ,the city was 1.59‰ ( χ 2=1.92, P<0.05).The top 5 birth defects were more finger(toe) or syndactyly,congenital heart disease,alpha thalassemia,Down's syndrome,neural tube defects.Conclusion:Mengla county was the region of ethnic minorities living,the economic,cultural,medical technology were backward,therefore,we should strengthen the health education,premarital examination,prenatal care,prenatal care and prenatal diagnosis,in order to reduce birth defects and improve the quality of the population.

  12. Reducing Risks of Birth Defects

    Science.gov (United States)

    ... number of cases, the infection can cause intellectual disability, hearing loss, and vision problems. CMV can be spread ... woman becomes infected during pregnancy. It can cause hearing loss, intellectual disability, and vision problems in infected infants. Diabetes Mellitus: ...

  13. Advances in the Relationship between Polymorphisms of Genes Involved in the Folate Metabolic Pathway and Birth Defects%叶酸代谢基因多态性与出生缺陷的关系

    Institute of Scientific and Technical Information of China (English)

    罗丽; 陈岳明; 王贤军

    2015-01-01

    With birth mortality decreasing significantly ,birth defects have become more serious in China. Increasing evidences supported the polymorphisms of genes involved in the folate metabolic pathway impact the occurrence of birth defects. MTHFR 677C>T polymorphism impacting the occurrence of neural tube defects had reached a consistent conclusion. However,the relationship between MTHFR 677C>T, MTHFR 1298A>C and cleft lip/palate,congenital heart disease,Down′s syndrome is still controversial. Researches seldom took further study on the correlation between MTR 2756A>G,MTRR 66A>G,RFC-1 80A>G polymorphism and birth defects. In this summary,we outlined the origination of folate,metabolic pathway and the association between the polymorphisms of genes involved in the pathway and birth defects.%随着我国新生儿出生死亡率明显降低,出生缺陷问题日益突出。在降低新生儿出生缺陷发生率的众多研究中,发现叶酸吸收代谢途径基因多态性与出生缺陷发生存在明显相关性。亚甲基四氢叶酸还原酶(MTHFR)677C>T多态性与神经管缺损发生明显相关已取得较为一致的结论。但MTHFR 677C>T、MTHFR 1298A>C在唇裂/腭裂、先天性心脏病、唐氏综合征的发生中所起的作用结论尚不统一,并且较少涉及叶酸代谢通路中甲硫氨酸合成酶(MTR)2756A>G、甲硫氨酸合成还原酶(MTRR)66A>G、还原型叶酸载体-1(RFC-1)80A>G多态性与出生缺陷的研究。就叶酸来源、吸收代谢途径及代谢途径关键基因多态性与出生缺陷的相关性进行综述。

  14. Monitoring and analysis of the Population Birth Defects in Tianjin Downtown from 2008 to 2010%天津市区2008~2010年人群出生缺陷监测资料分析

    Institute of Scientific and Technical Information of China (English)

    李宝娟

    2012-01-01

    OBJECTIVE To analyze the population birth defects prevalence and potential affecting factors in Tianjin downtown from 2008 to 2010. METHODS The data of fetus and infants in Tianjin city from 2008 to 2010 were collected and analyzed. RESULTS A total of 1 062 cases with birth defect were collected from 65 990 births, with an overall prevalence rate of 160.93/104 births. The rates in male and female births were 172.34/104 births and 146.65/104 births, and there was significant difference between the two groups (r = 6.902, P< 0.01). Compared with 20-29 years old, the rate was 189.61/104 births in an age ≥30 years group, especially, the rate was 482.76/104 births in an age ≥40 years group (χ2 = 18.849, P < 0.001). There was significant difference in premature delivery and low birth weight babies (χ2 = 404.491, P< 0.001; χ2 = 381.164, P < 0.001). The rate was 3 505.98 per 10 000 births in fetal death and stillbirth, early neonatal death and death with in 7-42 days. The rate was 25.91 times of live-births (χ2 = 3 663.76, P< 0.01). Birth defect risk factors included male births, elderly puerperal, premature delivery babies and babies with low birth weight. CONCLUSION Annual prevalence rate of birth defect in Tianjin presented an increasing trend. The improvement ability in diagnosis and monitoring should be partly accounted for it. Birth defects were more likely to occur in elderly puerpera's babies, premature and low birth weight babies. The babies were mortality in high and poor prognosis.%目的 了解2008~2010年天津市区人群出生缺陷的发生情况及其影响因素.方法 对2008~2010年居住在天津市市内6区的产妇所分娩的胎婴儿资料进行分析.结果 共收集围产儿65 990例,出生缺陷儿1 062例,发生率为160.93/万.男、女性胎婴儿出生缺陷发生率分别为172.34/万和146.65/万,差异有统计学意义(x2=6.902,P<0.01);与20~29岁相比,产妇年龄在30岁以上,尤其是40岁以上时,胎婴

  15. Research on the influence factors of birth defect in Zhongshan City%中山市出生缺陷发生的相关影响因素调查分析

    Institute of Scientific and Technical Information of China (English)

    熊付兴; 王丹; 史妙丽

    2016-01-01

    目的:调查分析中山市出生缺陷的相关影响因素,为出生缺陷一级干预提供决策支持。方法选择2014年1月至2016年1月中山市105例出生缺陷儿作为缺陷组,同期选择105例无出生缺陷的新生儿作为对照组。对两组父母的“国家免费孕前优生健康检查项目”档案中疾病史、用药史、孕育史、家族史、饮食营养、生活习惯、环境毒害物接触、社会心理因素以及孕前的各种医学检验结果进行分析。结果两组父母文化程度、在孕产史、用药史、饮食营养、生活习惯、生活环境、疾病史、家族遗传病史等因素比较,差异有统计学意义(P <0.05)。家庭经济收入低、孕期营养状况差、早孕期自然流产、死胎死产、曾用避孕药、被动吸烟、接解放射线是出生缺陷的危险因素。结论新生儿出生缺陷的危险因素较多,临床医生需加强宣传,指导女性进行婚前、孕前检查,养成良好的生活习惯,从而减少新生儿出生缺陷的发生。%Objective To investigate and analyze the related influence factors of birth defect in Zhongshan City,Providing decision support for the first -level intervention.Methods 105 children with birth defect in Zhongshan City from January of 2014 to January of 2016 were selected as defect group,and 105 children without birth defect were selected as control group.The disease history,medication history,birth history,family history,diet,living habits,environmental poisonexposure,social psy-chological factors and pre -pregnancy medical testing results from "national free pre pregnancy health check"archives were ana-lyzed.Results The differences in the degree of education,history of gestation,history of pharmacy,diet nutrition,living hab-it,diseases history,history of family genetic disease and some other factors of parents between two goups were statistically signifi-cant (P <0.05).The low family income,bad nutriture at

  16. International practice of rheumatoid arthritis registries. Foreign registries

    OpenAIRE

    Azamat Makhmudovich Satybaldyev; D E Karateev

    2014-01-01

    Review of the USA, Argentina, Australia, Japan, and European Union registries is presented. The similarities and differences between the registries in terms of populations of rheumatoid arthritis patients and the target goals are studied

  17. Psoriatic Arthritis Registries.

    Science.gov (United States)

    Sarzi-Puttini, Piercarlo; Varisco, Valentina; Ditto, Maria Chiara; Benucci, Maurizio; Atzeni, Fabiola

    2015-11-01

    The introduction of new biological drugs for the treatment of rheumatoid arthritis and spondyloarthritis has led to the creation of a number of registries in Europe and the United States. Most of them are sponsored by national rheumatology societies, and provide information that is useful in clinical practice concerning the clinical characteristics, efficacy, and safety of all licensed biological drugs. Their findings also help to improve our understanding of the quality of life and working ability of patients receiving biological drugs, and suggest methods for allocating resources. However, there are only a few registries for psoriatic arthritis, and efforts should be made to increase their number to obtain further reliable and useful data.

  18. 开封市出生缺陷影响因素病例对照研究%Case-control study on influencing factors of perinatal birth defects in Kaifeng city

    Institute of Scientific and Technical Information of China (English)

    王珊; 潘新娟; 余增丽

    2013-01-01

    [目的] 探讨开封市围产儿出生缺陷的影响因素,为出生缺陷干预提供科学依据. [方法] 2006年10月-2011年10月开封市468例出生缺陷儿的产妇为病例组,同一医院随机抽取646例于同时期分娩正常新生儿的产妇为对照组,进行回顾性调查,用单因素与多因素Logistic回归分析筛选出生缺陷的主要影响因素. [结果] 研究因素中,有12个影响因素的发生率病例组与对照组的差异有统计学意义(P<0.05),其中危险因素是7个,保护因素5个;对单因素分析中有统计学意义的变量进行多因素Logistic回归分析,其中,婚前体检(OR=0.65),经常食用鱼虾肉蛋类、牛奶豆类等优质蛋白类食物(OR=0.59)为出生缺陷的保护性因素;而母亲吸烟饮酒(OR=2.02)、母亲致畸因素接触史(OR=1.63)、孕育期用药(OR=4.23)、孕育期接触有害物质(OR=13.26)、居住地有污染源(OR=10.23)等5个因素为出生缺陷的危险因素. [结论] 母亲吸烟饮酒、母亲致畸因素接触史、孕育期用药、孕育期接触有害物质、居住地有污染源等因素为出生缺陷的主要危险因素.减少和控制孕期主要危险因素是预防出生缺陷的重要环节.%[Objective] To explore the influencing factors of perinatal birth defect,and provide scientific basis for intervention. [Methods] 468 perinatal birth defects infants were selected as case group,and 646 normal infants as control group. According to the birth date and sex matching principle,Logistic regression was used to analysis muti-factor. [Re-sults] Regular intake of fish,shrimp,meat,eggs,milk and beans during pregnancy(OR=0. 59) participating in pre-marital medical examination(OR = 0. 65) were the protective factors of birth defects. The habit of smoking and drinking(OR = 2. 02) , the history of mother exposure to teratogenic factors(OR= 1. 63) ,medication during pregnancy(OR = 4. 23) .exposure to harmful substances during pregnancy(OR = 13. 26

  19. 已婚育龄妇女预防出生缺陷知识、态度和行为的调查%Survey of knowledge, attitudes and practice of preventing birth defects in married reproduction women

    Institute of Scientific and Technical Information of China (English)

    洪己东; 翁彦云; 徐沛金; 戴黎玫; 武英

    2015-01-01

    Objective To evaluate the effect of health education on preventing birth defects in community in terms of knowledge, attitude and practice (KAP) for married women in reproductive age. Method A self-designed general information form and a questionnaire on KAP of married women′s preventing birth defects were used to investigate the KAP among 300 married nulliparous women. Result The average rate of cognitive knowledge of birth defects was 60.8%, the average rate of cognitive behaviors was 59.2%, and the average rate of cognitive attitude was 67.4%. Conclusion In order to reduce the rate of birth defects and improve the quality of births, we should implement three-level prevention education system, enrich the health education methods to enhance the knowledge, attitude and behavior of married women.%目的:了解已婚育龄妇女预防出生缺陷知识、态度和行为情况,为制订相关的护理对策提供依据。方法采用自行设计的一般资料调查表和预防出生缺陷知识、态度和行为调查表对300名已婚育龄妇女进行调查。结果已婚育龄妇女预防出生缺陷知识平均认知率为60.8%,行为平均认知率为59.2%,态度平均认知率为67.4%。结论实施三级预防,采取多种形式的健康教育方法以提高已婚育龄妇女预防出生缺陷知识、态度和行为水平,从而降低出生缺陷率,提高出生人口的素质。

  20. Analysis on birth defect surveillance in south Xicheng District, Beijing%北京市西城南区围产儿出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    赵丽霞; 王淼

    2011-01-01

    Objective To analyze the birth defect of south Xicheng District, Beijing from 2008 to 2010, and observe the feature of the birth defect incidence. Methods Statistics and analysis of birth defect infants from 6 hospitals of south Xicheng district in Beijing were performed, 293 perinatal infants and 88 infants (induction of labour in second trimester) were found. Results The incidence of birth defect of south Xicheng district in Beijing from 2008 to 2010 was 14.51‰. There were 20190 perinatal infants, and 132 of them were dead. The mortality was 6.54‰. 25 of them were infants with birth defects. The percentage was 18. 98%. The incidence of birth defect in these 293 cases, from high to low, in turn were: congenital heart disease (3.37‰) , polysyndactyly (2.82‰) , deformity of external ear (1.04‰), syndactyly (0. 74‰) , anorectal atresia (0.45‰) , cleft lip(0.35‰) , microtia(0.35‰). Conclusion As the incidence rate of congenital heart disease and other defects were quite high, intensify health care in perinatal period should be promoted, and the level of antenatal diagnosis should be enhanced.%目的 分析北京市西城南区2008-2010年出生缺陷监测结果,了解本地区出生缺陷发生情况.方法 对2008-2010年北京市西城南区6家助产机构产科孕满28周至出生后7d的出生缺陷儿293例,以及因出生缺陷进行中期引产的胎儿88例进行出生缺陷结果分析.结果 2008-2010年北京市西城南区围产儿出生缺陷发生率为14.51‰;20190名围产儿中共132例围产儿死亡,死亡率为6.54‰,其中出生缺陷25例,占围产儿死亡的18.98%;293例出生缺陷发生率由高到低依次为先天性心脏病(3.37‰)、多指(趾)(2.82‰)、外耳其他畸形(1.04‰)、并指(0.74‰)、直肠肛门闭锁或狭窄(0.45‰)、唇裂(0.35‰)、小耳(0.35‰).结论 进一步提高产前诊断水平,增强围孕保健措施.

  1. Analysis of the trend in prevalence of birth defects in Guangxi from 2001 to 2010%2001-2010年广西壮族自治区围生儿出生缺陷分析

    Institute of Scientific and Technical Information of China (English)

    曾萼

    2012-01-01

    Objective To investigate the prevalence of birth defects and its variation from 2001 to 2010 in Guangxi.Methods According to national birth defect monitoring program,all perinatal infants in the birth defects monitoring hospitals in Guangxi from 2001 to 2010 were investigated and statistically analyzed for prevalenee of birth defects( per ten thousand),incidence rates of major birth defects,category and correlating factors.Results In recent 10 years,540 449 perinatal infants were monitored.And 10 897 cases of birth defects were identified with a prevalence rate of 201.63 per ten thousand.The main deformities were fetal edema syndrome,polydactyly,congenital heart disease,cleft lip and external ear malformation.The prevalence of birth defects among boys in the period of 2001-2010was significantly higher than that among girls and that in rural areas was significantly higher than that in the urban areas,and the differences were significant ( x2 =43.71,4.04 respectively,both P < 0.05 ).The prevalence rate of birth defects in 35 ~ age group was the highest and it was significantly higher than that in the < 20 age group,~ 25 age group,25 age group and 30 ~ age group ( x2 =9.17,41.33,58.77,29.10 respectively,all P < 0.05 ).There was an ascending tendencyin prevalence rate of birth defects in the period of 2001 and 2005,and there was a descending tendency in the period of 2005 and 2010.Conclusion Strengthening tertiary prevention measures,and improving skills of the medical wokers for prenatal diagnosis were effective measures to reduce the prevalence of birth defects.%目的 分析广西壮族自治区2001-2010年围生儿出生缺陷特征及变化趋势.方法 按照国家出生缺陷监测方案,对2001-2010年广西壮族自治区围生儿出生缺陷监测医院的围生儿进行出生缺陷监测,统计分析出生缺陷的发生率、类别和相关因素.结果 10年共监测围生儿540 449例,其中出生缺陷儿10 897例,发生率为201.63/万.出

  2. Analysis of perinatal birth defects monitoring results in Gansu province from 2001 to 2008%甘肃省2001年~2008年围产儿出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    丁秀琴; 郭瑛泉; 张玲; 廖丽萍

    2011-01-01

    Objective: To discuss the trend of birth defects incidence, species and changes in Gansu province, in order to provide evidence for preventive measure.Methods: According to Chinese Birth Defects Monitoring Program and Maternal and child health surveillance program in Gansu Province, to monitor perinatal birth in 43 hospitals in Gansu province from 2001 to 2008.Results:( 1 ) In 8 years, the birth defects average incidence is 11.043 per thousand, its trend began go up in 2004, but there is no statistical difference between every years.(2) And the birth defects average incidence no statistical difference between boys and girls ( P >0.05 ); The pregnant motheres age distribution characterized with "two side high and middle low", the lowest incidence (5.9 -9.7 per thousand ) is at 25 - 29 years age group, higher in country than in city ( P < 0.05 ).( 3 ) In 8 years, most common birth defects were neural tube defects, congenital hydrocephalus, cleftlip, talipes equinovarus, limb shorten, polydactyly and congenital heart disease.Neural tube defects and congenital hydrocephalus were always in first there birth defects in Gansu province.Conclusion: Neural tube defects, congenital hydrocephalus, cleftlip are high incidence in all birth defects, which are result of genetic or environmental factors, or interaction of both.Prevention is preior to therapy.Aiming at high detection rate of birth defects, to establish effective administrative intervention and medical care meature.%目的 探讨甘肃省出生缺陷的发生率、种类及变化趋势,为预防措施的制定提供依据.方法 按<中国出生缺陷监测方案>及<甘肃省妇幼卫生监测方案>,对甘肃省2001年~2008年间在43家监测医院住院分娩的围产儿进行监测.结果 (1)8年间的出生缺陷发生率平均为110.43/万,2004年起有明显上升趋势,各年份间出生缺陷发生率无显著的统计学差异.(2)胎儿性别间出生缺陷发生率

  3. Risk factors for birth defects:A community-based child survey%社区儿童的出生缺陷影响因素探讨

    Institute of Scientific and Technical Information of China (English)

    李敏; 赵丽萍; 商颖; 蔡建华; 周维谨; 车焱

    2011-01-01

    目的:了解以社区为基础的出生缺陷发生水平和有关影响因素,为出生缺陷的预防和孕期保健提供依据.方法:采用多阶段分层整群抽样方法,从我国东、中、西部地区9个中等发达省份中各抽取1个国家人口计生委信息采集抽样县,每个县抽取2个乡镇,再从中各抽取2~4个居委(村),调查其中所有已婚育龄妇女≤9岁子女的出生缺陷发生及相关信息,通过单因素分析和多元logistic回归分析,探讨出生缺陷的影响因素.结果:调查对象共3958例,出生缺陷发生率为1.80%.单因素卡方检验发现母亲产龄、文化程度、流产史、孕期微量营养素补充、产检机构与出生缺陷发生有关(P <0.05).多元logistic回归分析显示,产龄16~20岁(OR=2.53,95 % CI:1.25~5.10)、有人工流产史(OR=3.32,95% CI:1.69~6.51)、吸烟(OR=3.34,95 % CI:1.04~10.75)、孕期未补充微量元素(OR=1.84,95%CI:1.07~3.16)、在乡镇及以下机构产前检查(OR=1.70,95% CI:1.06~2.74)的母亲生育出生缺陷儿的危险较高.结论:出生缺陷预防干预应重点关注既往有人工流产史、低龄、吸烟孕妇对象,重视基层产前检查机构服务能力建设,提供优质孕期监测与营养保健咨询服务.%Objective; To explore the prevalence and risk factors for birth defects ( BD) among children in 9 provinces of China. Methods; By using stratified, random cluster sampling methods, 17 townships and 36 rural villages and urban neighbourhood were sampled from 9 provinces of China. All married women aged between 20 - 49 years old were investigated and a questionnaire survey on birth defects of their children under 9 year - old was conducted. Chi - square test and multivariate logistic regression analysis were used to evaluate the association between BD and maternal risk factors. Results: There were 3 958 respondents, and the prevalence of BD was 1.80%. Results of chi - square tests indicated that maternal age

  4. Birth Control

    Science.gov (United States)

    Birth control, also known as contraception, is designed to prevent pregnancy. Birth control methods may work in a number of different ... eggs that could be fertilized. Types include birth control pills, patches, shots, vaginal rings, and emergency contraceptive ...

  5. 宜昌市城区2008~2010年医院出生缺陷补漏调查%Investigation on the mend Leakage on the birth defects in Yichang between 2008 and 2010

    Institute of Scientific and Technical Information of China (English)

    周小葵

    2012-01-01

    OBJECTIVE To understand the omissions and quality of report card on the birth defects in Yichang city between 2008 and 2010. METHODS We investigated the omissions and quality of report card on the birth defects in midwifery agency of Yichang city on the basis of the National monitoring project of health of mothers and children. RESULTS The leakage rate was 7.49%, and the mistaking rate was 1.26% in the tables and cards. The two rates decreased year by year. CONCLUSION The fundamental guarantee of improving the quality of monitoring in the birth defects was the strengthening of management and supervision , and the raising responsibility of medical staff.%目的 了解宜昌市城区2008~2010年医院出生缺陷漏报及报告卡质量情况.方法 根据《全国妇幼卫生监测方案》对出生缺陷监测质量的要求,对城区各助产机构出生缺陷漏报及报告卡质量情况进行调查.结果 2008~2010年宜昌市城区医院出生缺陷漏报率平均达7.49%;表、卡填写差错率平均达1.26%.漏报率和差错率都有逐年下降趋势.结论 加强管理,坚持督导,提高医务人员责任心,是提高出生缺陷监测质量的根本保证.

  6. Analysis on Related Factors of Newborn Birth-defects in 36 Hospitalized Childbirth%36例住院分娩围生儿出生缺陷的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    臧丽莉

    2015-01-01

    目的:了解盐城地区住院分娩围生儿出生缺陷状况,探索引起出生缺陷的相关因素方法对2010年10月—2014年5月盐城市第一人民医院住院分娩的4347新生儿进行监测,标准为孕满28周~产后7d的围生儿结果检出出生缺陷儿36例,出生缺陷发生率为8.28‰,在不同新生儿性别、产母职业之间差异无统计学意义。但产妇年龄35-39、40岁及以上年龄组(13.33‰,45.46‰),多胎多产(GnPn,n≥3,为51.55‰)及经产者(17.96‰),发生率显著升高(P28 gestational weeks within the 7 days perineonata period were monitored in hospital of 180 of Quanzhou.Results: There were 36 out of 4347 newborns with various types of birth-defect and the birth-defect rate was 8.28‰. There was no statistically signiifcant difference in the occurrence of birth-defect from the neonatal genders and occupationsof pregnant women. But the rates were signiifcantly higher when the pregnant women were 35-39 and 40 years old,multi-pregnancies and multi-labors(51.55‰)and multiparas(17.96‰),and there was statistical signiifcant difference(P<0.05,P<0.01).Conclusions: Birth-defects are related to the maternal age,numbers of pregnancies and labors,but not related to the sex of neonates and occupations of pregnant women.

  7. 南京市六合区2007-2011年出生缺陷监测结果分析%Analysis on the monitoring results of birth defect in Luhe district in 2007-2011

    Institute of Scientific and Technical Information of China (English)

    陈寿花

    2014-01-01

    目的:了解本地区围产儿出生缺陷的发生情况,及时发现影响出生缺陷的可疑因素,为制定干预措施提供依据。方法按照国家出生缺陷监测方案的要求,对2006年10月1日~2011年9月30日在六合区有产科的医院出生的、孕满28周至产后7天内的32562例围产儿进行监测。结果出生缺陷儿171例,出生缺陷儿发生率为5.25‰;出生缺陷的发生与环境因素、孕母年龄、出生性别等有关。结论进行优生优育宣传指导,为孕妇创造优良的生育环境及合理的均衡饮食,提高产前诊断技术,适时终止妊娠,可有效降低出生缺陷发生率。%Objective :in this study, we monitored and analyzed the perinatal birth defect in Luhe district, Nanjing in order to promptly establish proper measures to control this disease.Methods: According to the national birth defect monitoring protocol, 32562 perinatal samples during 28 weeks after pregnancy and 7 days after born were monitored. The term was from October 1, 2006 to September 30, 2011. The data were colected from al the hospitals or centers in Luhe district.Results: the monitoring results showed that 171 cases were diagnosed birth defect. The ratio was 5.25‰. It related to multi-influence factors including environment, maternal’s age on perinatal outcomes and baby gender etc.Conclusions:The perinatal birth defect could be controled efficiently by several ways, such as folowing the pregnant quality guideline, providing good environments to pregnant women, and improving the pre-pregnant diagnosis in terminal pregnancy.

  8. Malaysian Twin Registry.

    Science.gov (United States)

    Jahanfar, Shayesteh; Jaffar, Sharifah Halimah

    2013-02-01

    The National Malaysian Twin Registry was established in Royal College of Medicine, Perak, University Kuala Lumpur (UniKL) in June 2008 through a grant provided by UniKL. The general objective is to facilitate scientific research involving participation of twins and their family members in order to answer questions of health and wellbeing relevant to Malaysians. Recruitment is done via mass media, poster, and pamphlets. We now have 266 adult and 204 children twins registered. Several research projects including reproductive health study of twins and the role of co-bedding on growth and development of children are carried out. Registry holds annual activities for twins and seeks to provide health-related information for twins. We seek international collaboration.

  9. Study on 204 birth defects of the prenatal in the city of Taiyuan from 1997 to 2008%1997年-2008年太原地区204例出生缺陷回顾性分析

    Institute of Scientific and Technical Information of China (English)

    闫惠娜; 张月莲; 郑梅玲

    2012-01-01

    目的 了解1997年-2008年间太原市出生缺陷发生情况,为进一步制定干预措施提供依据.方法 将1997年-2008年12年中在我院妇产科终止妊娠的出生缺陷忠儿按年限分为1997年-2002年(前六年)组和2003年-2008年(后六年),并对其种类、发生率及城乡分布进行回顾性分析.结果 (1) 12年中神经管畸形的发生率为56.11/万,居于首位,占全部出生缺陷的32.35%,虽然后六年的神经管畸形的发生率低于前6年,但无统计学差异(x2=3.70,P>0.05).(2)后6年中28W前B超诊断率(1.12%)比前六年(0.41%)显著提高(x2=7.49,P<0.05).(3)前6年中城市与农村出生缺陷发生率分别为133.94/万、545.45/万,后6年城市与农村出生缺陷发生率分别为129.64/万、436.50/万,(x2=42.27,P<0.05; x2 =44.47,P<0.05)农村的平均发生率为城市的3.7倍,明显高于城市.结论 神经管畸形的发生在我省仍较为突出,只有加强对神经管畸形的预防,加强优生优育知识的宣传,改善农村生活环境,提高产前诊断率水平,才有可能有效性地降低出生缺陷的发生.%Objective: In order to formulate for further interventions, investigated the types, time of making a definite diagnosis, incidence of prenatal death defects in the city of Taiyuan, from 1997 to 2008. Methods; made two different groups, the first group form the year of 1997 to 2002 and the second group form the year of 2003 to 2008. Results: (1) The most of birth defects were Neural Tube defects and the percentage was 32. 35. (2) Morbidity by B ultrasound before 28w compare to after 28w were different between 1997 - 2002 and 2003 - 2008. (x2 = 7.49, P < 0.05 ) , the later six years' diagnostic rate of type - B ultrasonic before 28w was higher than the one of former six years. (3) Incidence of death defects were relate to the gravidas's place of residence, the gravidas' s birth defect rate form countries was higher than who form the cities whatever the first group or

  10. Gestational Age, Birth Weight, Intrauterine Growth and Risk for Epilepsy

    OpenAIRE

    Sun, Yuelian; Vestergaard, Mogens; Carsten B Pedersen; Christensen, Jakob; Basso, Olga; Olsen, Jørn

    2007-01-01

    The authors evaluated the association between gestational age, birth weight, intrauterine growth and epilepsy in a population-based cohort of 1.4 million singletons born in Denmark (1979-2002). A total of 14,334 individuals were registered with epilepsy in the Danish National Hospital Register as inpatients (1979-2002) and outpatients (1995-2002). Information on gestational age and birth weight was obtained from Danish Medical Birth Registry. Children small at birth were identified through tw...

  11. The Vermont oxford neonatal encephalopathy registry: rationale, methods, and initial results

    Directory of Open Access Journals (Sweden)

    Pfister Robert H

    2012-06-01

    Full Text Available Abstract Background In 2006, the Vermont Oxford Network (VON established the Neonatal Encephalopathy Registry (NER to characterize infants born with neonatal encephalopathy, describe evaluations and medical treatments, monitor hypothermic therapy (HT dissemination, define clinical research questions, and identify opportunities for improved care. Methods Eligible infants were ≥ 36 weeks with seizures, altered consciousness (stupor, coma during the first 72 hours of life, a 5 minute Apgar score of ≤ 3, or receiving HT. Infants with central nervous system birth defects were excluded. Results From 2006–2010, 95 centers registered 4232 infants. Of those, 59% suffered a seizure, 50% had a 5 minute Apgar score of ≤ 3, 38% received HT, and 18% had stupor/coma documented on neurologic exam. Some infants experienced more than one eligibility criterion. Only 53% had a cord gas obtained and only 63% had a blood gas obtained within 24 hours of birth, important components for determining HT eligibility. Sixty-four percent received ventilator support, 65% received anticonvulsants, 66% had a head MRI, 23% had a cranial CT, 67% had a full channel encephalogram (EEG and 33% amplitude integrated EEG. Of all infants, 87% survived. Conclusions The VON NER describes the heterogeneous population of infants with NE, the subset that received HT, their patterns of care, and outcomes. The optimal routine care of infants with neonatal encephalopathy is unknown. The registry method is well suited to identify opportunities for improvement in the care of infants affected by NE and study interventions such as HT as they are implemented in clinical practice.

  12. Analysis of influencing factors of birth defect based on health education%基于健康教育的出生缺陷影响因素分析

    Institute of Scientific and Technical Information of China (English)

    刘月芬; 李佳樾

    2012-01-01

    Teratogenic factors are closely related with living environment and human production and life, but are ignored easily. Therefore, the key link of reducing birth defect is to highlight public awareness effectively. This article indicated potential high-risk teratogenic factors in people' s life from the point of view of physics and chemistry so as to strengthen the concept of mass prevention and treatment and improve the effectiveness of preventing birth defects.%致畸因子与生存环境息息相关,其与人类生产生活密不可分,但却易被忽视.因此,降低出生缺陷至关重要的环节是有效地提高防范意识.该文从物理、化学等角度指出人们生活中潜在的高危致畸因素,强化群防群治理念,提高防范出生缺陷的效力.

  13. 河池市金城江区2010-2014年新生儿出生缺陷监测分析%Birth Defects Monitoring Analysis of Jin Chengjia Ng area in Hechi City from 2010 to 2014

    Institute of Scientific and Technical Information of China (English)

    李娟; 兰仙朵

    2015-01-01

    Objective To monitor birth defects of Jin Chengjiang area in Hechi city from 2010 to 2014. Methods Selected birth defects monitoring data of Jin Chengjiang area in Hechi city from 2010 to 2014. Results The birth defect rate of Jin Chengjiang area was 18.85 ‰ from 2010 to 2014, there is an upward trend in the incidence of birth defects. Male’s birth defects incidence rate was higher than baby?daughter, birth defects rate of pregnant women beyond 35 ages was highest. The first there disease of birth defects rate were congenital heart disease, congenital hydrocephalus and merger of cleft lip cleft palate respectively. The mainly diagnosis basis was clinical diagnosis and B ultrasonic diagnosis. Conclusion Perinatal birth defects of Jin Chengjiang district was higher than the national level, birth defects rate was present an upward trend year by year, and need to pay a attention.%目的:对河池市金城江区2010—2014年出生缺陷新生儿进行监测分析。方法收集河池市金城江区2010—2014年出生缺陷监测资料。结果2010—2014年金城江区新生儿缺陷发生率为18.85‰,出生缺陷儿的发生率呈逐年上升的趋势。男性围产儿的出生缺陷发生率高于女性,孕妇年龄≥35岁发生出生缺陷率最高。出生缺陷发生率位于前三的分别为先天性心脏病、先天性脑积水及唇裂合并腭裂。主要依据为临床诊断和B超诊断。结论金城江区围产儿出生缺陷高于全国水平,出生缺陷发生率呈逐年上升的趋势,需要引起重视。

  14. 广西不同民族新生儿出生情况及出生缺陷分析%The analysis of the birth condition and defects of different ethnic of Guangxi

    Institute of Scientific and Technical Information of China (English)

    陈继昌; 林墨菊; 邱萍; 罗琳琳; 王麟; 农铮

    2013-01-01

    Objective This article was to analyze the situation of newborns at Liuzhou ,Guangxi,in 2012,and understand the newborns’ information in order to pro-vide a theoretical basis for the development of maternal and child health interventions .Method We used statistics to analyze the 46877 cases of different ethnical newbo-rns in 2012 at Liuzhou city,Guangxi.Results The sex ratio of newborns in 2012 was lower than that of the national average;the incidence rate of premature and low birth weight newborns were higher than other regions;cesarean section rate was lower than that of the national average;the incidence of birth defects close to the national aver-age.Conclusion We should accordingly strength the propagation of relative knowledge about the pregnant period health .Provide guidance to the nutrition of pregnant women,promote fetal development and reduce the incidence of premature birth and low birth weight infants and birth defects ,which is the prior task to the maternal health care.%目的分析广西柳州市2012年出生新生儿情况及出生缺陷,了解不同民族新生儿出生的基本资料及出生缺陷情况,为制定孕产期保健和儿童保健干预措施提供理论依据。方法统计分析2011年广西柳州市46877例不同民族新生儿出生资料。结果2012年柳州市出生新生儿性别比低于全国平均水平;早产儿发生率和低出生体重发生率高于其他地区水平;剖宫产率低于全国平均水平;出生缺陷发生率接近国内平均水平。结论加强孕产期保健等相关知识宣教,进行孕妇营养指导,促进胎儿发育,减少早产和低体重儿的发生,减少出生缺陷的发生是孕产期保健的重点工作。

  15. 中枢神经系统出生缺陷相关因素的调查%Investigation on the Correlation Factors of Birth Defects of Central Nervous System

    Institute of Scientific and Technical Information of China (English)

    龙熙德; 丁华新; 舒仁和

    2009-01-01

    [Objective] To discuss the correlation factors of birth defects of central nervous system(CNS) in the area of Dongting Lake, and to provide the references for establishing intervention measures to prevent birth defects of CNS. [Methods] Among 89147 pregnant women who had been pregnant for at least 28 weeks and delivered after 7 days during the period from January 1997 to December 2006, mothers of 115 children patients who were confirmed to suffer from congenital malformation of CNS were collected as the case group. According to 1:2 matched, mothers of 230 normal newborns with the same condition were chosen as comparison group. Then, questionnaire investigation and match research were conducted. [Results] Family history of congenital malformation, father touching chemicals, fathers' drinking index, fever caused by cold, touching pesticide during pregnancy, smoking passively were main dangerous factors of birth defects of CNS, with OR value of 14.50, 10.10, 5.00, 4.53, 3.89 and 1.76, respectively. Education level, B-ultrasound in the middle of pregnancy and taking folic acid were protection factors, with βj value of -0.48, -2.36 and -2.51, respectively and OR value less than 1. The difference between scores of questionnaire of knowledge of birth defects obtained by patient case group and comparison group had statistical significance (P0.05). [Conclusion]Doing pre-marriage health education and pregnancy health care, and medically monitoring high risk population are keys to further reduce birth defects of CNS.%[目的]探讨中枢神经系统(CNS)出生缺陷的相关因素,为制定预防CNS出生缺陷干预措施提供参考依据.[方法]收集1997年1月至2006年12月期间孕满28周至产后7d的孕产妇89147例,其中确诊为CNS先天畸形患儿115例的母亲为病例组,按1:2配对,选取同等条件的230例正常新生儿的母亲为对照组,进行问卷调查、配对研究.[结果]先天畸形家族史、父接触化学物品、父饮酒指数、

  16. National registry of myocardial infarction

    OpenAIRE

    Amin Daemi; Mehdi Jafari

    2016-01-01

    The Registry of Myocardial Infarctions (MI Registry) is a national registry in Iran that collects and reports the data on myocardial infarctions. Its main advantage is that it covers the whole country and is mandatory for hospitals to register the MI cases in it. Then, the qualified individuals at the provincial and national levels can get intended reports and make appropriate decisions. Such reports, further to the policy makers and managers, can be very valuable for researchers. The regi...

  17. Rare birth defects associated with Morgagni hernia and segmental aplasia of uterine horn in bitch: Case reportDefeitos congênitos raros em cadela – relato de caso

    Directory of Open Access Journals (Sweden)

    Ricardo Santana de Lima

    2013-09-01

    Full Text Available Birth defects, deformities or abnormalities are terms used to describe developmental defects present at birth, most of which are rare in bitches. We report the case of a six-month old mongrel bitch corpse, which, when subjected to an anatomotopographic study revealed the presence of rare birth defects as Morgagni hernia and segmental aplasia of the right uterine horn with its attachment to the transverses muscle of abdominis. In association with HM, we observed the presence of dextrocardia and a defect of the abdominal wall supraumbilical characteristic of incompletely Pentalogy of Cantrell’s, syndrome so far described only in humans. In association with segmental aplasia of the uterine horn, we observed the ipsilateral presence of the renal hypoplasia and ureteral agenesis. The diagnosis of those abnormalities was based on anatomical findings and confirmed histologically. Despite the rarity and complexity of the abnormalities first described in bitches, the literature suggested that the prognosis may be favorable to the life of the animal. However, early diagnosis is essential to avoid the potential complications of those diseasesDefeitos congênitos, deformidades ou anormalidades são termos usados para descrever defeitos no desenvolvimento presentes ao nascimento. A maioria destes, como a aplasia segmentar uterina, é de ocorrência rara em cadelas. Relata-se o caso de um cadáver de cadela, sem raça definida, de seis meses de idade, que ao ser submetido ao estudo anatomotopográfico revelou a presença de aplasia segmentar uterina (ASU associada à hérnia de Morgagni (HM, agenesia ureteral (AU e hipoplasia renal direita (HR. Além destas anormalidades, foi observada a presença de dextrocardia e de um defeito da parede abdominal supraumbilical, que caracterizam a forma incompleta da pentalogia de Cantrell, só descrita em humanos. O diagnóstico destas anormalidades foi baseado nos achados anatômicos e confirmado histologicamente. A

  18. Data Management and Site-Visit Monitoring of the Multi-Center Registry in the Korean Neonatal Network

    OpenAIRE

    Choi, Chang Won; Park, Moon Sung

    2015-01-01

    The Korean Neonatal Network (KNN), a nationwide prospective registry of very-low-birth-weight (VLBW, < 1,500 g at birth) infants, was launched in April 2013. Data management (DM) and site-visit monitoring (SVM) were crucial in ensuring the quality of the data collected from 55 participating hospitals across the country on 116 clinical variables. We describe the processes and results of DM and SVM performed during the establishment stage of the registry. The DM procedure included automated pro...

  19. Analysis of the report of perinatal birth defects monitoring in fengtai district of beijing from 2006 to 2010%北京市丰台区2006-2010年出生缺陷监测数据分析

    Institute of Scientific and Technical Information of China (English)

    唐艳; 张静; 房春玉

    2012-01-01

    Objective: By understanding the incidence of perinatal birth defect in Fengtai district of Beijing, in order to explore the influencing factors and develop interventions to reduce the incidence of birth defect. Methods; The data of perinatal birth defects from 2006 to 2010 were gathered from monitoring hospitals in Fengtai district. Results: The incidence of birth defect in Fengtai district was 110.5/10000 and there was a upward trend during 5 years. The perinatal birth defects stood on the first 3 rank of incidence list followed by Polydactyly, Congenital malformation of auricle, Congenital heart defects. There were certain correlation among birth defects, the mother's residence geography, gestational age, birth weight, gestational age of birth. Conclusion: It is valuable to reduce the incidence by a well - planned birth defects monitoring and preventive health care program.%目的 分析丰台区出生缺陷的发生情况及相关因素,探索降低出生缺陷发生的干预措施.方法 对2006~2010年北京市丰台区出生缺陷监测资料进行统计分析.结果 2006~2010年出生缺陷总发生率为110.5/万,各年的出生缺陷发生率呈上升趋势;按照出生缺陷病种分类,位于前3位的为多指(趾)、外耳畸形、先天性心脏病;男婴与女婴出生缺陷发生率比较具有显著性差异;母亲户籍、分娩年龄、婴儿出生体重、孕周等是出生缺陷发生的影响因素.结论 做好出生缺陷监测工作,加强出生缺陷三级预防,是降低出生缺陷发生的必要措施.

  20. 成都市某区六年来新生儿出生缺陷分析%The Analysis of Birth Defects of Newborns During the Past Six Years in a District of Chengdu

    Institute of Scientific and Technical Information of China (English)

    刘梅; 周礼英; 吴怀勇; 张志华; 张倩; 李青林; 汪渝; 杜彪; 王园

    2015-01-01

    Objective We studied puerperae from one district in Chengdu who registered, gave birth or had induced la-bor in our district during 2007 and 2013. For our sample,we investigated on subjects who had newborns with defects,or stillbirths. We summarized the factors on puerperae to have newborns with defects. We also summarized the examination methods and the de-velopment of newborn defects. We investigated newborns’ defects and the dynamic changes so that we can have a theoretical basis in preventing newborn defects. Methods We included puerperae from one district in Chengdu who registered,gave birth or had induced labor in our district during 2007 and 2013. All subjects were founded by using the registration information from pediatrics, obstetrics and health divisions. Puerperae with birth defects information were included. They were divided into two groups accord-ing to their due dates. We did retrospective survey on both groups,studied their medical records,and made records about puerperae who gave birth to defected newborns or had stillbirths. We used χ2test with collected data on both groups. Results During recent years,maternal health awareness might have increased. Puerperae in Group B were significantly better than puerperae in Group A in terms of premarital medical examinations,periodic medical examinations during pregnancy,and folic acid supplementation during pregnancy. Birth defects screening methods relied mainly on Down’s screening and fetal ultrasound examination. Birth defects were still mainly focused on eye,ear,face,or neck malformation,cryptorchidism,limbs,fingers or toes deformity. Conclusion During the past three years, chromosome abnormalities were found more frequently. It might suggest that there was a correlation with high-risk contacts.%目的:对成都市某区2007年至2013年在我区建卡、分娩或引产孕产妇,调查其中具有缺陷新生儿及死胎的产妇相关信息,总结近年来出生缺陷的产妇因素、检

  1. 北京平谷区三年出生缺陷产前超声筛查分析%Prenatal Ultrasound Screening Analysis for the Birth Defects within 3 Years in Pinggu District in Beijing

    Institute of Scientific and Technical Information of China (English)

    刘大平

    2013-01-01

    Objective Ultrasonography in prenatal screening for birth defects diagnosis,understanding of the region the incidence of birth defects,in order to reduce the occurrence of congenital malformation.Methods In 2007,2008,my area,2009 (statistical time for every year from October 1st to next September 30th) delivery within seven days after the diagnosis of birth defects and ultrasound examination results were analyzed.Results In three years the region a total of 162 infants with birth defects,a total of 60 cases of prenatal ultrasound screening detected fetal malformation,and confirmed after birth ultrasound diagnosis correctly,ultrasound screening for the detection rate for 37 %.Missed diagnosis of malformations mainly for cardiac malformation in 45 cases,means (toe) abnormalities in 26 cases,lip,palate 8 cases.Conclusions Ultrasound examination can be detected in the vast majority of congenital fetal malformations,at present this area for gastroschisis,anencephaly and other obvious fetal malformation high detection rate,on minor malformations such as finger (toe) abnormalities in three years has never been detected,on fetal cardiac abnormalities by ultrasonography technology needs to be further improved.%目的 探讨超声产前筛查对出生缺陷的诊断价值,了解本地区出生缺陷的发生动态,为减少先天畸形的发生提供依据.方法 将平谷区2007-2009年(统计时间为每年10月1日至次年9月30日)分娩后7d内诊断的出生缺陷儿与超声检查结果,进行对比分析.结果 3年全区共分娩畸形儿162例,产前超声共筛查出60例畸形胎儿,且出生后证实超声诊断正确,超声筛查的检出率为37%.漏诊心脏畸形45例,指(趾)异常26例,唇、腭裂8例等.结论 超声检查可以检出绝大多数的胎儿先天畸形,目前平谷区对腹裂、无脑儿等明显的胎儿畸形检出率高,对微小畸形如指(趾)异常3年从未检出过,对胎儿心脏异常的超声检查技术有待进一步提高.

  2. The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects

    OpenAIRE

    Coppedè, Fabio

    2015-01-01

    Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions of chromosome 21, favoring its abnormal segregation during maternal meiosis. Subsequently, more than 50 small case-control studies investigated whether or not maternal polymorphisms of folate pathway genes could be risk factors for the birth of a child with Down syndrome (DS), yielding conflicting and inconclusive res...

  3. Birth Plans

    Science.gov (United States)

    ... licensed to handle low-risk births and whose philosophy emphasizes educating expectant parents about the natural aspects ... in which they give birth. Do you want music and low lighting? How about the freedom to ...

  4. Defect-mediated relaxation in the random tiling phase of a binary mixture: birth, death and mobility of an atomic zipper.

    Science.gov (United States)

    Tondl, Elisabeth; Ramsay, Malcolm; Harrowell, Peter; Widmer-Cooper, Asaph

    2014-03-14

    This paper describes the mechanism of defect-mediated relaxation in a dodecagonal square-triangle random tiling phase exhibited by a simulated binary mixture of soft discs in 2D. We examine the internal transitions within the elementary mobile defect (christened the "zipper") that allow it to move, as well as the mechanisms by which the zipper is created and annihilated. The structural relaxation of the random tiling phase is quantified and we show that this relaxation is well described by a model based on the distribution of waiting times for each atom to be visited by the diffusing zipper. This system, representing one of the few instances where a well defined mobile defect is capable of structural relaxation, can provide a valuable test case for general theories of relaxation in complex and disordered materials. PMID:24628178

  5. The effect of health education on preventing birth defects in a community of Nanjing City%南京市社区预防出生缺陷健康教育的效果评价

    Institute of Scientific and Technical Information of China (English)

    许碧云; 胡娅莉; 崔晓宁; 姚敬; 洪红

    2012-01-01

    目的 评价南京市鼓楼区预防出生缺陷健康教育的效果,为以社区为基础的出生缺陷一级预防提供科学依据.方法 选择2008年3月~2009年7月在南京市鼓楼区建围产期保健小卡的孕妇作为调查对象并进行出生缺陷相关知识宣传教育,采用问卷调查早孕人群干预前后出生缺陷知识、态度和行为的变化,分析其影响因素.结果 干预后早孕人群对预防出生缺陷相关知识的总得分(34.43±3.10)高于干预前(29.56±4.77) (t=58.50,P<0.001).干预后21道题目回答正确率均高于干预前,其中仅1道题干预前后正确率的差异无统计学意义(P=0.458).年龄、文化程度、职业和家庭人均月收入对干预效果都有明显的影响(均有P<0.05).年龄大者比年龄小者,本科及以上文化程度比初中及以下者,医护人员比工人,家庭人均月收入1 001 ~元、2 001~元、3 001~元、4 001~元、≥5 001元比≤1 000元者对知识的掌握明显增多.结论 利用健康教育的模式对早孕人群进行干预,能提高其预防出生缺陷的能力.应对文化程度偏低、家庭收入较少的育龄妇女进行预防出生缺陷知识的普及.%Objective To evaluate the effect of health education on preventing birth defects in Gulou District of Nanjing City, in order to provide scientific evidence for the first-level prevention of the birth defect based on community. Methods Health education was conducted among the pregnant women who build card of perinatal health during March 2008 to July 2009 in Gulou District of Nanjing City. The questionnaire was used to investigate the knowledge, attitude and practice of birth defect prevention among the early pregnant women. The results were analyzed to find the changes of knowledge , attitude and practice of birth defect prevention before- and after- intervention, and to find the influencing factors of intervention effect. Results There was significant promotion (i = 58. 50

  6. The Use of Health Education and Behavior Intervention Measures for Prevention of the Occurrence of Birth Defects%运用健康教育和行为干预措施预防出生缺陷的发生

    Institute of Scientific and Technical Information of China (English)

    焦亚会

    2014-01-01

    Objective:To investigate effective behavioral intervention and measures of health education on the prevention of birth defects,so as to provide effective and theoretical basis for its application.Method:Professional training was conducted on the pediatrician and the obstetrician gynecologist in Monitoring Hospital according to the monitoring program related to birth defects issued by China.Screening and statistical analysis was carried out according to the related criteria of the“Main Diagnosis Handbook of Congenital Malformation”.Result:28947 cases of perinatal babies in the present study were surveyed.There were a total of 573 cases with birth defects,the incidence was 19.8‰in all the perinatal babies.After health education and behavior intervention,perinatal defect rate was decreased to 16.4‰,and there were significant differences before and after the education and intervention(P<0.05).Conclusion:Analysis results demonstrate that strengthening health education and behavior intervention on pregnant woman can effectively reduce the incidence of birth defects,which has an important significance for improving the quality of the population,and thus it is necessary to pay attention to these measures.%目的:研究对预防出生缺陷而进行的有效的行为干预和健康教育措施,为其应用提供有效的理论依据。方法:根据国家颁发的相关出生缺陷监测方案对监测医院的儿科和妇产科的医生进行专业培训。并按《主要先天畸形诊断手册》相关标准进行筛查并统计分析。结果:本次研究中对28947例围产儿进行调查,共有573例有出生缺陷,发生率占所有围产儿的19.8‰;经健康教育和行为干预后,围产儿缺陷率降低至16.4‰(473例),前后比较差异有统计学意义(P<0.05)。结论:经比较可见,加强对孕产妇的健康教育和行为干预能够有效的降低出生缺陷的发生,对于提高人口素质具有重要的意义,应值得重视。

  7. Effect analysis of the surveillance and intervention of severe birth defects on decreasing the incidence of live birth with Down's syndrome in Zhongshan%中山地区重大出生缺陷监控和干预措施的实施对降低唐氏综合征出生率的效果分析

    Institute of Scientific and Technical Information of China (English)

    王莹; 江陵; 吴剑波; 陈昂; 陈咏莲; 李莉敏

    2012-01-01

    Objective; To analysize the effect of the surveillance and intervention of severe birth defects on decreasing the incidence of live birth with Down's syndrome in Zhongshan, 2010 -2011. Methods; Prenatal screening of Down's syndrome has been free in residents since January 1, 2010. The Surveillance and Intervention were carried out at the same time. Data of the surveillance were analyzed, 2008 -2011 , comparing the difference of the incidences. Results; After the surveillance and intervention, the rate of prenatal diagnosis of Down's syndrome increased significantly. The rate of live births with Down's syndrome decreased in 2010 -2011 (1. 63 -0. 64/ten thousand) compared with 2008 and 2009 (3. 5-3. 78/ten thousand). Conclusion; The Surveillance and intervention of severe birth defects on were effective on decreasing the incidence of live birth with Down's syndrome in Zhongshan.%目的 分析2010年-2011年中山地区对重大出生缺陷采取的监控和干预措施在降低唐氏综合征出生率方面的实际效果.方法 2010年1月1日始中山市对户籍人口实施免费产前筛查唐氏综合征,并进行监控和干预措施,通过2008年-2011年中山市出生缺陷监测网监测唐氏综合征儿数据,比较唐氏综合征出生率的差异.结果 实施重大出生缺陷监控和干预措施后,唐氏综合征的产前诊断率显著提高,唐氏综合征出生率2010年-2011年(1.63-0.64/万)较2008年-2009年(3.5-3.78/万)有明显下降(P =0.001).结论 2010年-2011年中山市对重大出生缺陷采取监控和干预措施在降低唐氏综合征出生率方面起到很好的效果.

  8. Establishing a Twin Registry in Guinea-Bissau

    DEFF Research Database (Denmark)

    Bjerregaard-Andersen, Morten; Gomes, Margarida A; Joaquím, Luis C;

    2013-01-01

    , diabetes mellitus, metabolic syndrome, and infectious diseases such as HIV, tuberculosis, and malaria. A major focus area is also the etiology of low birth weight and how epigenetic processes might modulate the consequences of low birth weight in Sub-Saharan Africa. For this, monozygotic twin studies...... represent a powerful tool. Though twin studies have been carried out by the Bandim Health Project for more than 30 years, the renewed registry described here was officially established in 2009 and includes both a cohort of newborn twins and a cohort of young and adult twins. Currently more than 1,500 twins...

  9. Playing the role of preventing and curing birth defects in the second grade general hospitals%发挥二级综合医院在防治出生缺陷中的作用

    Institute of Scientific and Technical Information of China (English)

    张园园; 蔡慧兰; 吴晨

    2013-01-01

    目的 通过对6个县市二级综合医院产前筛查等情况进行调查研究,探讨预防出生缺陷的新途径.方法 采取定性定量相结合的办法、访谈法、问卷调查法等.结果 二级综合医院开展遗传咨询、产前筛查、产前诊断、新生儿疾病筛查等方面工作做得不够,婚检和婚前保健工作存在薄弱环节.结论 我国出生缺陷总发生率呈上升趋势,加强二级综合医院妇产科建设,充分发挥其产前筛查、遗传咨询、产前诊断职能,有利于帮助解决出生缺陷这一突出的公共卫生问题.%Objective To investigate and study the conditions of prenatal screening and other items in the second grade general hospitals of six counties and cities, and to explore a new way to prevent birth defects. Methods A combination of qualitative and quantitative ways, interviews, questionnaires and other approaches were taken. Results Carrying out genetic counseling, prenatal screening & diagnosis, neonatal disease screening and other items were not good enough in the second grade general hospitals. Meanwhile, the antemarital physical examination and premarital health service had weaknesses. Conclusion The total incidence rate of birth defects in China increases in the ascendant trend. Therefore, it is vital to strengthen the construction of the department of obstetrics and gynecology in the second grade general hospitals, and the hospitals should fully display its functional role in prenatal screening, genetic counseling, prenatal diagnosis which can help resolve the prominent public health problem of birth defects.

  10. Worldwide variability in deceased organ donation registries

    OpenAIRE

    Rosenblum, Amanda M.; Li, Alvin Ho-Ting; Roels, Leo; Stewart, Bryan; Prakash, Versha; Beitel, Janice; Young, Kimberly; Shemie, Sam; Nickerson, Peter; Garg, Amit X

    2012-01-01

    The variability in deceased organ donation registries worldwide has received little attention. We considered all operating registries, where individual wishes about organ donation were recorded in a computerized database. We included registries which recorded an individual's decision to be a donor (donor registry), and registries which only recorded an individual's objection (non-donor registry). We collected information on 15 characteristics including history, design, use and number of regis...

  11. Experience of reasons and intervention measures of 7 cases of birth defects of multi finger(toe)%出生缺陷多指(趾)儿7例原因分析及干预措施

    Institute of Scientific and Technical Information of China (English)

    呙明蓉

    2014-01-01

    目的:探讨出生缺陷多指(趾)儿的原因及干预措施。方法:2009年10月-2013年9月收治出生缺陷多指(趾)儿7例,针对其发生率、孕周、胎儿性别、孕妇的年龄、文化程度、孕早期情况、出生缺陷、转归等7个方面进行统计及分析。结果:发生率:出生缺陷儿的发生率70.63‰,围产儿的死亡率32.60‰;多指(趾)儿发生率26.92%,围产儿存活率100%。孕周:37周1例,38周3例,39周2例,40周1例,7例均为足月产。胎儿性别:男4例,女3例,性别没有差异。孕妇年龄:26岁1例,27岁1例,28岁2例,29岁2例,30岁1例,孕妇年龄没有差别。文化程度:小学1例,初中3例,大专3例。孕早期情况:感冒1例,发热1例,无异常5例。畸形部位:多指5例,多趾1例,右足并趾1例。转归:活产7例,均为活产。结论;对7例出生缺陷儿的原因分析,加强对优生优育的宣教,避免不良生活习惯,避免孕早期病毒感染和孕期的保健,提高生存质量的重要措施。%Objective:To explore the reasons and intervention measures of birth defects of multi finger(toe).Methods:7 cases with birth defects of multi finger(toe) were selected from October 2009 to September 2013.We analyzed the incidence,gestational weeks,fetus gender,maternal age,culture degree,early pregnancy,birth defects and prognosis.Results:The incidence rate of birth defects in children was 70.63‰,and perinatal mortality was 32.60‰.Multi finger(toe) rate was 26.92%,and the perinatal survival rate was 100%.Gestational age:1 case was 37 weeks,3 cases were 38 weeks,2 cases were 39 weeks,1 case were 40 weeks,7 cases were all full-term birth.The sex of the fetus:4 cases were male,3 cases were female,there was no gender differences.Age of pregnant women:1 case was 26 years old,1 case was 27 years old,2 cases were 28 years old,2 cases were 29 years old,1 case was 30 years old,there was no difference in

  12. 出生缺陷多指(趾)儿7例原因分析及干预措施%Experience of reasons and intervention measures of 7 cases of birth defects of multi finger(toe)

    Institute of Scientific and Technical Information of China (English)

    呙明蓉

    2014-01-01

    目的:探讨出生缺陷多指(趾)儿的原因及干预措施。方法:2009年10月-2013年9月收治出生缺陷多指(趾)儿7例,针对其发生率、孕周、胎儿性别、孕妇的年龄、文化程度、孕早期情况、出生缺陷、转归等7个方面进行统计及分析。结果:发生率:出生缺陷儿的发生率70.63‰,围产儿的死亡率32.60‰;多指(趾)儿发生率26.92%,围产儿存活率100%。孕周:37周1例,38周3例,39周2例,40周1例,7例均为足月产。胎儿性别:男4例,女3例,性别没有差异。孕妇年龄:26岁1例,27岁1例,28岁2例,29岁2例,30岁1例,孕妇年龄没有差别。文化程度:小学1例,初中3例,大专3例。孕早期情况:感冒1例,发热1例,无异常5例。畸形部位:多指5例,多趾1例,右足并趾1例。转归:活产7例,均为活产。结论;对7例出生缺陷儿的原因分析,加强对优生优育的宣教,避免不良生活习惯,避免孕早期病毒感染和孕期的保健,提高生存质量的重要措施。%Objective:To explore the reasons and intervention measures of birth defects of multi finger(toe).Methods:7 cases with birth defects of multi finger(toe) were selected from October 2009 to September 2013.We analyzed the incidence,gestational weeks,fetus gender,maternal age,culture degree,early pregnancy,birth defects and prognosis.Results:The incidence rate of birth defects in children was 70.63‰,and perinatal mortality was 32.60‰.Multi finger(toe) rate was 26.92%,and the perinatal survival rate was 100%.Gestational age:1 case was 37 weeks,3 cases were 38 weeks,2 cases were 39 weeks,1 case were 40 weeks,7 cases were all full-term birth.The sex of the fetus:4 cases were male,3 cases were female,there was no gender differences.Age of pregnant women:1 case was 26 years old,1 case was 27 years old,2 cases were 28 years old,2 cases were 29 years old,1 case was 30 years old,there was no difference in

  13. Birth outcomes of cases with unclassified multiple congenital abnormalities and pregnancy complications in their mothers depending on the number of component defects. Population-based case-control study.

    Science.gov (United States)

    Puhó, Erzsébet H; Czeizel, Andrew E; Acs, Nándor; Bánhidy, Ferenc

    2008-09-01

    Multiple congenital abnormalities (MCA) represent the most severe category of structural birth defects, (i.e. congenital abnormalities [CA]). Unfortunately, most MCA are not recognized and/or identified as MCA syndromes or MCA associations in the clinical practice. The term unclassified MCA (UMCA) is used for this category of MCA. We decided to evaluate the component CA of UMCA cases. The population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities (1980-1996) was evaluated. 'False' MCA, such as complex CA, polytopic field defects and sequences were excluded from the category of MCA. In addition, MCA syndromes caused by chromosomal aberrations and major mutant genes with preconceptional origin were excluded from the dataset of the Surveillance. MCA syndromes caused by teratogens and MCA associations with well-defined component CA were also excluded in the study. Thus, only UMCA cases (i) without the recognition of previously delineated MCA syndromes (ii) and/or without the identification of new MCA syndromes or (iii) caused by random combination of CA were included in the study. We compared data from 1349 cases with UMCA, 2405 matched population controls without any CA, and 21 494 malformed controls with isolated CA. There was a higher rate of stillbirth and a moderate male excess in UMCA cases, a somewhat shorter gestational age at delivery and an obvious reduction in birthweight. The intrauterine fetal growth retardation and rate of low-birthweight newborns showed an association with the number of component CA in UMCA cases. A similar association was not found with gestational age and the rate of preterm birth. UMCA represent one of the most severe categories of CA. The degree of intrauterine fetal growth retardation depends on number of component CA in UMCA cases.

  14. Analysis of 1540 neonates with birth defects related to different assisted reproductive technique%不同辅助生殖技术妊娠分娩的1 540例新生儿出生缺陷分析

    Institute of Scientific and Technical Information of China (English)

    王芳; 孙莹璞; 孔慧娟; 苏迎春; 郭艺红; 梁菊艳; 李朋粉

    2009-01-01

    目的 探讨不同辅助生殖技术妊娠分娩的新生儿出生缺陷的发生情况及影响因素.方法 对1998年10月至2006年12月在郑州大学第一附属医院生殖医学中心接受体外受精(IVF)助孕[IVF、卵母细胞胞质内单精子注射(ICSI)、冻融胚胎移植(Thaw-ET)]妊娠的孕妇分娩的1271例新生儿(体外受精组)及同期接受人工授精妊娠的孕妇所分娩的269例新生儿(人工授精组)的临床资料进行分析,比较两组及不同辅助生殖技术后出生的新生儿情况、出生缺陷及出生缺陷受累系统.结果 体外受精组中,IVF、ICSI、Thaw-ET后出生的低体重(LBW)儿分别为20.0%(134/671)、22.4%(92/410)、18.9%(36/190),也均高于人工授精组的11.5%(31/269),差异有统计学意义(P0.05).结论 不同体外受精助孕后多胎率明显升高,由此造成的相关风险也随之增加,但新生儿的出生缺陷并没有明显增加;减少多胎妊娠是保护出生新生儿健康的关键.%Objective To investigate the incidence of and clinical factors influencing neonatal birth defects from different assisted reproductive technology. Methods Between October 1998 and December 2006,1271 newborns from mothers treated by in vitro fertilization techniques [ including in vitro fertilization (IVF), intracytoplasmic sperm injection (1CSI) and thaw embryo transfer (Thaw-ET) ] matched with 269 newborns from mothers treated by artificial insemination were enrolled in Reproductive Medicine Center in First Hospital Affiliated to Zhengzhou University. Their medical information was analyzed retrospectively to compared neonatal characteristics, the incidence of birth defect and anomalous organs involved between in vitro fertilization group and artificial insemination group. Results In group of in vitro fertilization, those newborns with low birth weight from IVF, ICSI and Thaw-ET were 20. 0% ( 134/671 ), 22. 4% (92/410), 18.9% (36/190)respectively, which were more than 11.5% (31/269) cases

  15. 2009-2010年北京市西城区德胜社区出生缺陷监测情况%Monitoring and analysis on birth defects in Desheng community in Xicheng district of Beijing 2009-2010

    Institute of Scientific and Technical Information of China (English)

    褚喆萍; 薄新生; 纪晋文

    2012-01-01

    目的 了解北京市西城区德胜社区出生缺陷发生特点,为干预措施提供科学依据.方法 对2009-2010年北京市西城区德胜社区的人群出生缺陷监测结果进行分析.结果 2009、2010年德胜社区出生缺陷发生率分别为25.91%、22.58%,出生缺陷发生顺位前3位的分别是先天性心脏病(52.50%)、外耳其他畸形(15.00%)、并指(趾)(10.00%),出生缺陷发生与孕周、孕妇年龄有关(P<0.05),出生缺陷的诊断手段主要为B超和临床.结论 要关注高龄孕妇围生期保健,做好孕产妇系统管理,规范产前检查和预防,降低出生缺陷发生率.%[Objective]To investigate the epidemiological characteristics of birth defects in Desheng community in Xicheng District of Beijing, provide the scientific basis for intervention measures. [Methods] The monitoring results of birth defects in Desheng community in Xicheng District of Beijing during 2009-2010 were analyzed. [Results] The incidence rate of birth defects in Desheng community in 2009 and 2010 was 25. 91‰ and 22. 58‰ respectively. The top three birth defects were congenital heart disease (52.50% ), congenital external ear malformations (15.00% ) and syndactyly (10.00% ). The birth defects were related to gesta-tional age and maternal age (P <0. 05). The main diagnostic methods of birth defects were B-ultrasound and clinical diagnosis. [Conclusion] It is necessary to pay attention to perinatal health care among senile gravida, carry out the system management among pregnant women, and improve the prenatal examination and prevention, in order to reduce the incidence rate of birth defects.

  16. Physical inactivity affects skeletal muscle insulin signaling in a birth weight-dependent manner

    DEFF Research Database (Denmark)

    Mortensen, Brynjulf; Friedrichsen, Martin; Andersen, Nicoline Resen;

    2014-01-01

    We investigated whether physical inactivity could unmask defects in insulin and AMPK signaling in low birth weight (LBW) subjects.......We investigated whether physical inactivity could unmask defects in insulin and AMPK signaling in low birth weight (LBW) subjects....

  17. Analysis on current situation of birth defects in Panyu district of Guangzhou city%广州市番禺区出生缺陷现状分析

    Institute of Scientific and Technical Information of China (English)

    陶小君; 赵如青; 辜俊梅

    2013-01-01

    目的:利用完善的计划生育三级服务网络进行多个目标病种的群体干预,逐步建立以降低唐氏综合征(包括18三体综合征)、重型地中海贫血及重大体表、内脏、骨骼畸形患儿出生率为目的的产前筛查和产前诊断服务体系.方法:唐氏筛查为中孕期血清学唐氏筛查,联合检测AFP、HCG、uE3三种标记物;地中海贫血采用MCV、MCH初筛和高效液相色谱(HPLC)复筛,阳性者进行基因诊断;地中海贫血、唐氏筛查高风险家庭进一步行产前诊断确诊.孕18~ 24周重大体表、内脏、骨骼畸形采用彩色多普勒进行排畸筛查.结果:1 320个唐氏筛查高风险家庭和91个地中海贫血高风险家庭进行了产前诊断,结果确诊染色体异常23例,重症地中海贫血22例.超声排畸筛查诊断重大体表、内脏、骨骼畸形183例.三大病种共确诊并终止妊娠共229例.结论:完善的计划生育三级服务网络有助于减少唐氏综合征(包括18三体综合征)、重型地中海贫血及重大体表、内脏、骨骼畸形患儿出生.%Objective: To conduct population intervention of various diseases by improved three -stage service network of family-planning, and gradually construct prenatal screening and diagnostic service system for the purpose of reducing birth rate of infants with Down's syndrome (including trisomy 18 syndrome) , severe thalassemia, and major external, visceral, skeletal malformations. Methods: The methods to screen Downs syndrome included serological examination, joint detection of alpha fetal protein (AFP) , human chorionic gon-adotropin ( HCG) , and uncojugated estriol; while methods to screen thalassemia included preliminary screening with mean corpuscular volume (MCV) and mean corpuscular hemoglobin ( MCH) , secondary screening with high performance liquid chromatography ( HPLC) , the positive cases received genetic diagnosis; the high risk families of Downs syndrome and thalassemia further

  18. A study on relationship between serum folate-related metabolism and birth defects%血清叶酸相关代谢与出生缺陷发生的关系研究

    Institute of Scientific and Technical Information of China (English)

    卢晓琳; 王芳; 包怡华; 付立平; 吴丽华; 张霆

    2011-01-01

    目的 比较出生缺陷高发和低发地区--山西吕梁和北京怀柔地区孕妇血清叶酸、维生素B12及其代谢产物同型半胱氨酸水平,探讨造成两地出生缺陷发生率差异的营养学因素.方法 选择吕梁地区的140名孕妇和怀柔地区的133名孕妇作为研究对象,采集研究对象的静脉血,比较两地区孕妇血清叶酸、维生素B12和同型半胱氨酸水平差异.结果 吕梁地区孕妇血清平均叶酸、维生素B12水平显著低于怀柔地区(t值分别为6.10、13.77,均P<0.05).同时吕梁地区孕妇血清同型半胱氨酸水平显著高于怀柔地区(t=15.32,P<0.05),吕梁地区叶酸、维生素B12缺乏率显著高于怀柔地区(χ2值分别为7.84、61.02,均P<0.05).结论 出生缺陷高发地区孕妇血清叶酸、维生素B12水平显著偏低,叶酸相关一碳单位代谢水平异常在一定程度上解释了高出生缺陷发生率的原因.%Objective To explore the nutritional factors that affect the difference in prevalence of birth defects between Lvliang in Shanxi with high prevalence and Huairou in Beijing with low prevalence by comparing the serum levels of folio acid ( FA ), vitamin B12( VitB12 )and homooysteine ( Hcy ) of pregnant women in these two areas. Methods One hundred and forty pregnant women in Lvliang and 133 pregnant women in Huairou were recruited. Their serum levels of FA, VitB12 and Hcy were analyzed and compared. Results The average levels of FA and VitB12 of pregnant women in Lvliang were significantly lower than those in Huairou ( t was 6.10 and 13.77 respectively,P < 0.05 ), but the average serum level of Hcy in Lvliang was significantly higher ( t= 15.32, P < 0.05 ). The deficiency rate of FA and VitB12 in Lvliang was significantly higher than that in Huairou (X2 was 7.84 and 61.02 respectively, P < 0.05 ). Conclusion The serum levels of FA and VitB12in pregnant women are significantly low in the area where the prevalence of birth defects is high. The

  19. 孕前风险评估对出生缺陷的影响分析%Impact Analysis of Pre Pregnancy Risk Assessment on the Effect of Birth Defects

    Institute of Scientific and Technical Information of China (English)

    张国荣; 张红; 肖桂梅

    2015-01-01

    目的:探讨实施育龄妇女孕前风险评估对降低出生缺陷的干预效果。方法选择在我院进行免费孕前筛查的650例育龄妇女为干预组,进行孕前风险评估;随机抽取650例在县人民医院住院分娩,且未进行孕前风险评估的产妇为对照组。比较两组观察对象优生知识知晓情况、孕期营养指导、叶酸服用及出生缺陷发生情况等。结果干预组对象优生知识知晓率、孕期营养指导率、叶酸服用率均明显优于对照组,差异有统计学意义( P<0.05)。干预组围产儿出生缺陷的发生率为4.6‰(3/650),明显低于对照组的12.3‰(8/650),差异具有统计学意义( P<0.05)。结论孕前风险评估可有效识别出育龄妇女自身存在的危险因素,通过采取有针对性的干预,有效降低了出生缺陷率。%Objective To investigate the effect of intervention on implementation of pre pregnant women risk assessment on the effect of thebirthdefects.Methods 650casesofreproductiveagewomenoffreescreeningbeforepregnancyinthehospitalwereselectedasthein-tervention group , and the pre pregnancy risk assessment on them was done .650 patients in county -level people′s hospital who did not carry out pre pregnancy risk assessment were randomly selected as the control group .The eugenic knowledge , nutrition guidance during pregnancy , folic acid and birth defects incidence between the two groups were compared .Results Through comparing with the control group , the eugenic knowledge rate , nutrition guidance during pregnancy rate , the rate of folic acid in the intervention group were significant-ly better than that of the control group , and the difference was statistically significant (P<0.05).The perinatal birth defects incidence rate of intervention group was 4.6‰(3/650), and it was significantly lower than that of the control group of 12.3‰(8/650), with significant difference (P<0.05).Conclusion

  20. Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed.

    Science.gov (United States)

    Conlin, Ava Marie S; Bukowinski, Anna T; Gumbs, Gia R

    2015-08-26

    The National Smallpox Vaccine in Pregnancy Registry (NSVIPR) actively follows women inadvertently vaccinated with smallpox vaccine during or shortly before pregnancy to evaluate their reproductive health outcomes. Approximately 65% of NSVIPR participants also inadvertently received Anthrax Vaccine Adsorbed (AVA) while pregnant, providing a ready opportunity to evaluate pregnancy and infant health outcomes among these women. AVA-exposed pregnancies were ascertained using NSVIPR and electronic healthcare data. Rates of pregnancy loss and infant health outcomes, including major birth defects, were compared between AVA-exposed and AVA-unexposed pregnancies. Analyses included AVA-exposed and AVA-unexposed pregnant women who also received smallpox vaccine 28 days prior to or during pregnancy. Rates of adverse outcomes among the AVA-exposed group were similar to or lower than expected when compared with published reference rates and the AVA-unexposed population. The findings provide reassurance of the safety of AVA when inadvertently received by a relatively young and healthy population during pregnancy.

  1. The influence of birth weight and body mass in early adulthood on early coronary heart disease risk among Danish men born in 1953

    DEFF Research Database (Denmark)

    Osler, Merete; Lund, Rikke; Kriegbaum, Margit;

    2009-01-01

    retrieved from birth certificates and conscript records, respectively, were followed from 1978 until 2005 (between age 25 and 52 years) for incident fatal and non-fatal CHD. Data on CHD were obtained through record linkage to the Cause of Death Registry and the National Patient Registry. During follow...... with a combination of low birth weight and overweight in young adulthood....

  2. The influence of birth weight and body mass in early adulthood on early coronary heart disease risk among Danish men born in 1953

    DEFF Research Database (Denmark)

    Osler, Merete; Lund, Rikke; Kriegbaum, Margit;

    2009-01-01

    retrieved from birth certificates and conscript records, respectively, were followed from 1978 until 2005 (between age 25 and 52 years) for incident fatal and non-fatal CHD. Data on CHD were obtained through record linkage to the Cause of Death Registry and the National Patient Registry. During follow...... for individuals with a combination of low birth weight and overweight in young adulthood....

  3. Worldwide variability in deceased organ donation registries.

    Science.gov (United States)

    Rosenblum, Amanda M; Li, Alvin Ho-Ting; Roels, Leo; Stewart, Bryan; Prakash, Versha; Beitel, Janice; Young, Kimberly; Shemie, Sam; Nickerson, Peter; Garg, Amit X

    2012-08-01

    The variability in deceased organ donation registries worldwide has received little attention. We considered all operating registries, where individual wishes about organ donation were recorded in a computerized database. We included registries which recorded an individual's decision to be a donor (donor registry), and registries which only recorded an individual's objection (non-donor registry). We collected information on 15 characteristics including history, design, use and number of registrants for 27 registries (68%). Most registries are nationally operated and government-owned. Registrations in five nations expire and require renewal. Some registries provide the option to make specific organ selections in the donation decision. Just over half of donor registries provide legally binding authorization to donation. In all national donor registries, except one, the proportion of adults (15+) registered is modest (donation decision mandatory to obtain a driver's license. Registered objections in non-donor registries are rare (organ donor registries worldwide necessitates public discourse and quality improvement initiatives, to identify and support leading practices in registry use. PMID:22507140

  4. Environmental Agents Service (EAS) Registry System of Records

    Data.gov (United States)

    Department of Veterans Affairs — The Environmental Agent Service (EAS) Registries is the information system encompassing the Ionizing Radiation Registry (IRR), the Agent Orange Registry (AOR), and...

  5. Preterm Birth

    Science.gov (United States)

    ... factors, and social, personal, and economic characteristics. Can anything be done to prevent a preterm birth? Preventing ... My last baby was born early. Is there anything I can do in this pregnancy to keep ...

  6. Epidemiology of Multiple Congenital Anomalies in Europe : A EUROCAT Population-Based Registry Study

    NARCIS (Netherlands)

    Calzolari, Elisa; Barisic, Ingeborg; Loane, Maria; Morris, Joan; Wellesley, Diana; Dolk, Helen; Addor, Marie-Claude; Arriola, Larraitz; Bianchi, Fabrizio; Neville, Amanda J.; Budd, Judith L. S.; Klungsoyr, Kari; Khoshnood, Babak; McDonnell, Bob; Nelen, Vera; Queisser-Luft, Annette; Rankin, Judith; Rissmann, Anke; Rounding, Catherine; Tucker, David; Verellen-Dumoulin, Christine; de Walle, Hermien; Garne, Ester

    2014-01-01

    BackgroundThis study describes the prevalence, associated anomalies, and demographic characteristics of cases of multiple congenital anomalies (MCA) in 19 population-based European registries (EUROCAT) covering 959,446 births in 2004 and 2010. MethodsEUROCAT implemented a computer algorithm for clas

  7. Validity of the stage of lung cancer in records of the Maastricht Cancer Registry, the Netherlands

    NARCIS (Netherlands)

    Schouten, LJ; Langendijk, JA; Jager, JJ; vandenBrandt, PA

    1997-01-01

    Information collected in a clinical study on a random sample of 99 patients with inoperable lung cancer, treated with radiotherapy, was compared to the staging information in the Maastricht cancer registry. Validity of sex (0% disagreements), date of birth (0%), histology (1% major disagreements) an

  8. Paper 3: EUROCAT data quality indicators for population-based registries of congenital anomalies

    DEFF Research Database (Denmark)

    Loane, Maria; Dolk, Helen; Garne, Ester;

    2011-01-01

    The European Surveillance of Congenital Anomalies (EUROCAT) network of population-based congenital anomaly registries is an important source of epidemiologic information on congenital anomalies in Europe covering live births, fetal deaths from 20 weeks gestation, and terminations of pregnancy for...

  9. Epidemiology of multiple congenital anomalies in Europe: A EUROCAT population-based registry study

    DEFF Research Database (Denmark)

    Calzolari, Elisa; Barisic, Ingeborg; Loane, Maria;

    2014-01-01

    BACKGROUND: This study describes the prevalence, associated anomalies, and demographic characteristics of cases of multiple congenital anomalies (MCA) in 19 population-based European registries (EUROCAT) covering 959,446 births in 2004 and 2010. METHODS: EUROCAT implemented a computer algorithm f...

  10. Introduction: Birth

    OpenAIRE

    Tyler, Imogen

    2009-01-01

    We are all born. Hannah Arendt suggests that the absence of this primary fact from histories of thought represents a significant lacuna in political and philosophical traditions. For Arendt natality, the capacity to begin, is the foundational fact of all thought, all politics and all action. Without some fundmental understanding of the place of birth, there can, she suggests, be no social change, no human future. Arendt’s insistence on thinking birth as the basis for politics is radical in th...

  11. Correlation analysis of 1206 cases of birth defects in prenatal screening and diagnosis%1206例出生缺陷产前筛查及产前诊断的相关情况分析

    Institute of Scientific and Technical Information of China (English)

    李东海

    2012-01-01

    OBJECTIVE To know the prenatal screening and diagnosis for maternal and infant health care sector, to provide reference for establishing corresponding prevention countermeasures. METHODS Selected a total of 1 206 infants with birth defect during the years of 2008-2011 in our hospital, retrospectively analyzed the prenatal screening and prenatal diagnosis results of birth defects, comparatively analyzed the ratio in different regions without prenatal screening. RESULTS The positive cases in antenatal screening accounted for 33.4% (403/1 206), positive in prenatal diagnosis accounted for 28.8% (347/ 1 206) , without prenatal screening accounted for 9.8% (118/1 206). Interim malformations induced accounted for 25.2% (304/1 206). The first 5 causes of prenatal diagnosis of defect were as follows: neural tube defects, congenital heart disease, cleft lip, chromosomal abnormalities and strephenopodia. The first 5 causes of defect was total 295 cases, proportion of 85.1%, which were as follows; 364 cases with congenital heart disease (53.1%) , ear deformity in 79 cases (11.5%) , cleft lip in 75 cases (10.9%), cryptorchidism in 62 cases (9.1%) , polydactyly in 49 patients (7.2%). The constituent ratio that without prenatal screening (1.4%) in towns was significant lower than in countries (15.4%) (P < 0.05). CONCLUSION In order to reduce the incidence of birth defects, it should strengthen exploration on limbs and features of five sense organs in prenatal screening and diagnosis, can not only concern about the value of screening, and ignore the importance of antenatal diagnosis.%目的 为了解本地区产前筛查及产前诊断状况,给妇婴保健部门制定相应的预防对策提供参考.方法 选择2008 ~2011年期间某院分娩的出生缺陷儿,共计1206例,回顾分析出出生缺陷儿产前筛查与产前诊断结果,对照分析不同区域未进行产前筛查者构成比.结果 产前筛查阳性者占33.4% (403/1206),产前诊断阳性者占28.8

  12. Cancer risk in Swedish women: the relation to size at birth

    OpenAIRE

    Andersson, S W; Bengtsson, C; Hallberg, L.; Lapidus, L; Niklasson, A; Wallgren, A; Hulthén, L

    2001-01-01

    The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional cancer registries through the year 1998. A positive and statistically significant increased risk for cancer was found with increasing birth weight or birth length for all site c...

  13. Cerebral palsy in eastern Denmark: declining birth prevalence but increasing numbers of unilateral cerebral palsy in birth year period 1986-1998

    DEFF Research Database (Denmark)

    Ravn, Susanne Holst; Flachs, Esben Meulengracht; Uldall, Peter

    2010-01-01

    The Cerebral Palsy Registry in eastern Denmark has been collecting cases using a uniform data sampling procedure since birth year 1979. Children are included by two child neurologists and an obstetrician. Information on pregnancy, birth, neonatal period, impairments and demographic data...... are registered. The total cerebral palsy birth prevalence has been significantly decreasing since the birth period 1983-1986 with 3.0 per 1000 live births until the period 1995-1998 with 2.1 per 1000 live births. The overall decrease was seen in preterm infants (...

  14. Cerebral palsy in eastern Denmark: declining birth prevalence but increasing numbers of unilateral cerebral palsy in birth year period 1986-1998

    DEFF Research Database (Denmark)

    Ravn, Susanne Holst; Flachs, Esben Meulengracht; Uldall, Peter

    2010-01-01

    The Cerebral Palsy Registry in eastern Denmark has been collecting cases using a uniform data sampling procedure since birth year 1979. Children are included by two child neurologists and an obstetrician. Information on pregnancy, birth, neonatal period, impairments and demographic data are...... registered. The total cerebral palsy birth prevalence has been significantly decreasing since the birth period 1983-1986 with 3.0 per 1000 live births until the period 1995-1998 with 2.1 per 1000 live births. The overall decrease was seen in preterm infants (...

  15. Knowledge, attitude and behavior investigation on the early pregnant couples about birth defects in Sanlin area%三林地区育龄夫妇预防出生缺陷知识态度行为调查

    Institute of Scientific and Technical Information of China (English)

    汪天英; 曲毅; 施榕; 胡国华; 王赟; 庄康璐; 宋徽江

    2013-01-01

    Objective:To study the current status of the knowledge,attitude and behavior of birth defect prevention among the early pregnant couples in Sanlin area of Pudong New District in order to provide the support for the community-based first level prevention of the birth defect,and provide reference for the publicity of prenatal and postnatal care.Methods:A questionnaire survey was made among the early pregnant couples who had established maternal Manual during the year of 2012 from April to September in Sanlin Community Health Service Center.Results:Among the 403 collected questionnaires,391 were valid with an effective rate of 97.02%.The survey results indicated the awareness rate towards the eugenic related knowledge was range from 42.20% to 97.95% among the couples of childbearing age in Sanlin area.The percentages of sources of the Eugenic knowledge obtained from were internet (73.91%),medical staffs (71.61%),books and newspaper (63.43 %),and TV broadcasting (50.13 %).The rates for premarital medical examination,pre-pregnancy medical examination,medical prenatal examination and planned pregnancy were 55.50%,42.97%,98.50% and 68.29%.Conclusion:Couples of childbearing age widely know the basics of preventing birth defects but not in a comprehensive degree.Majority of the couples have the positive attitude and action towards the promotion of eugenics.The critical time period of preventing birth defects is before the pregnancy and during the early stage of pregnancy.It is necessary to broaden the preconception and periconceptional care range in order to locate the entry points of level-one intervention and health education accurately.%目的:了解浦东新区三林地区育龄夫妇掌握出生缺陷知识的水平及其对此的态度及相关行为,为以社区为基础的出生缺陷一级提供依据,为做好优生优育预防知识的宣传提供参考.方法:用问卷调查方式,对2012年4月至9月在上海浦东新区三林社区卫

  16. Breast and Colon Cancer Family Registries

    Science.gov (United States)

    The Breast Cancer Family Registry and the Colon Cancer Family Registry were established by the National Cancer Institute as a resource for investigators to use in conducting studies on the genetics and molecular epidemiology of breast and colon cancer.

  17. Long term trends in prevalence of neural tube defects in Europe: population based study

    Science.gov (United States)

    Loane, Maria; de Walle, Hermien; Arriola, Larraitz; Addor, Marie-Claude; Barisic, Ingeborg; Beres, Judit; Bianchi, Fabrizio; Dias, Carlos; Draper, Elizabeth; Garne, Ester; Gatt, Miriam; Haeusler, Martin; Klungsoyr, Kari; Latos-Bielenska, Anna; Lynch, Catherine; McDonnell, Bob; Nelen, Vera; Neville, Amanda J; O’Mahony, Mary T; Queisser-Luft, Annette; Rankin, Judith; Rissmann, Anke; Ritvanen, Annukka; Rounding, Catherine; Sipek, Antonin; Tucker, David; Verellen-Dumoulin, Christine; Wellesley, Diana; Dolk, Helen

    2015-01-01

    Study question What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid fortification of food does not exist? Methods This was a population based, observational study using data on 11 353 cases of NTD not associated with chromosomal anomalies, including 4162 cases of anencephaly and 5776 cases of spina bifida from 28 EUROCAT (European Surveillance of Congenital Anomalies) registries covering approximately 12.5 million births in 19 countries between 1991 and 2011. The main outcome measures were total and live birth prevalence of NTD, as well as anencephaly and spina bifida, with time trends analysed using random effects Poisson regression models to account for heterogeneities across registries and splines to model non-linear time trends. Summary answer and limitations Overall, the pooled total prevalence of NTD during the study period was 9.1 per 10 000 births. Prevalence of NTD fluctuated slightly but without an obvious downward trend, with the final estimate of the pooled total prevalence of NTD in 2011 similar to that in 1991. Estimates from Poisson models that took registry heterogeneities into account showed an annual increase of 4% (prevalence ratio 1.04, 95% confidence interval 1.01 to 1.07) in 1995-99 and a decrease of 3% per year in 1999-2003 (0.97, 0.95 to 0.99), with stable rates thereafter. The trend patterns for anencephaly and spina bifida were similar, but neither anomaly decreased substantially over time. The live birth prevalence of NTD generally decreased, especially for anencephaly. Registration problems or other data artefacts cannot be excluded as a partial explanation of the observed trends (or lack thereof) in the prevalence of NTD. What this study adds In the absence of mandatory fortification

  18. The danish multiple sclerosis registry

    DEFF Research Database (Denmark)

    Brønnum-Hansen, Henrik; Koch-Henriksen, Nils; Stenager, Egon

    2011-01-01

    Introduction: The Danish Multiple Sclerosis (MS) Registry was established in 1956. Content: The register comprises data on all Danes who had MS in 1949 or who have been diagnosed since. Data on new cases and updated information on persons with an MS diagnosis already notified are continuously...

  19. The Danish Shoulder Arthroplasty Registry

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe; Jakobsen, John; Brorson, Stig;

    2012-01-01

    (70% women) were reported to the registry between January 2006 and December 2008. Mean age at surgery was 69 years (SD 12). The most common indications were a displaced proximal humeral fracture (54%) or osteoarthritis (30%). 61% were stemmed hemiarthroplasties, 28% resurfacing hemiarthroplasties, 8...

  20. 27 CFR 24.115 - Registry number.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Registry number. 24.115... OF THE TREASURY LIQUORS WINE Establishment and Operations Application § 24.115 Registry number. Upon approval of the application, the appropriate TTB officer will assign a registry number to the bonded...

  1. Gastroschisis and associated defects: an international study.

    LENUS (Irish Health Repository)

    Mastroiacovo, Pierpaolo

    2007-04-01

    Our objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.

  2. 广东省1997-2007年医院监测出生缺陷趋势分析%Study on the changes of incidence rates on birth defects through hospital based surveillance program in Guangdong province during 1997-2007

    Institute of Scientific and Technical Information of China (English)

    李兵; 张小庄; 叶宁; 穆荔; 夏建红; 黄秀健; 何少兰

    2008-01-01

    Objective To analyze the tendency of hospital based surveillance incidence rates of birth defects in Guangdong province to provide reference evidence for related intervention program. Methods Data from hospital based birth defects surveillance of Guangdong province during 1997-2007 were analyzed retrospectively. Results The overall surveillance rates of birth defects in Guangdong province showed an increasing trend form 98.9 per 10 000 birth in 1997 to 244.2 per 10 000 birth in 2007. Among the frequently seen birth defects, the rate of congenital heart diseases increased sharply, but the rates of congenital talipes equinovarus, polydactyly, cleft lip with/without cleft palate showed a slight increasing trend.It seemed that there was a significant difference between different maternal age interval and gender of the infants. Mother's illness, drug use, and exposure to environment harmful factors in early pregnancy stage, high maternal age, negative bearing history were the suspect risk factors for birth defects. Conclusion The increasing trend of surveillance rate of birth defects seemed to be comprehensively affected by the factors as: method being adopted, target and extension of birth defects surveillance, technology used for diagnosis, kinds of risk factor,and quality control on surveillance programs.%目的 分析广东省医院出生缺陷监测发生趋势.方法 对1997-2007年广东省医院出生缺陷监测网数据进行回顾性描述和趋势分析.结果 广东省出生缺陷医院监测总发生率呈逐年上升趋势,自1997年的98.9/万上升为2007年的244.2/万;在常见出生缺陷类型中,先天性心脏病呈急剧上升,先天性足内翻、多指(趾)、总唇腭裂呈轻微上升;母亲不同年龄段、不同性别围产儿间出生缺陷发生率的差异有统计学意义;早期产前诊断的比例逐渐上升,并对监测出生缺陷发生率有影响;母亲孕早期患病、用药、接触环境有害因素

  3. A renal registry for Africa: first steps.

    Science.gov (United States)

    Davids, M Razeen; Eastwood, John B; Selwood, Neville H; Arogundade, Fatiu A; Ashuntantang, Gloria; Benghanem Gharbi, Mohammed; Jarraya, Faiçal; MacPhee, Iain A M; McCulloch, Mignon; Plange-Rhule, Jacob; Swanepoel, Charles R; Adu, Dwomoa

    2016-02-01

    There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African Association of Nephrology (AFRAN) and the African Paediatric Nephrology Association (AFPNA) recognize the importance of good registry data and plan to establish an African Renal Registry. This article reviews the elements needed for a successful renal registry and gives an overview of renal registries in developed and developing countries, with the emphasis on Africa. It then discusses the proposed African Renal Registry and the first steps towards its implementation. A registry requires a clear purpose, and agreement on inclusion and exclusion criteria, the dataset and the data dictionary. Ethical issues, data ownership and access, the dissemination of findings and funding must all be considered. Well-documented processes should guide data collection and ensure data quality. The ERA-EDTA Registry is the world's oldest renal registry. In Africa, registry data have been published mainly by North African countries, starting with Egypt and Tunisia in 1975. However, in recent years no African country has regularly reported national registry data. A shared renal registry would provide participating countries with a reliable technology platform and a common data dictionary to facilitate joint analyses and comparisons. In March 2015, AFRAN organized a registry workshop for African nephrologists and then took the decision to establish, for the first time, an African Renal Registry. In conclusion, African nephrologists have decided to establish a continental renal registry. This initiative could make a substantial impact on the practice of nephrology and the provision of services for adults and children with ESRD in many African countries.

  4. New registry: National Cancer Patient Registry--Colorectal Cancer.

    Science.gov (United States)

    Wendy, L; Radzi, M

    2008-09-01

    Colorectal cancer is emerging as one of the commonest cancers in Malaysia. Data on colorectal cancer from the National Cancer Registry is very limited. Comprehensive information on all aspects of colorectal cancer, including demographic details, pathology and treatment outcome are needed as the management of colorectal cancer has evolved rapidly over the years involving several disciplines including gastroenterology, surgery, radiology, pathology and oncology. This registry will be an important source of information that can help the development of guidelines to improve colorectal cancer care relevant to this country. The database will initially recruit all colorectal cancer cases from eight hospitals. The data will be stored on a customized web-based case report form. The database has begun collecting data from 1 October 2007 and will report on its first year findings at the end of 2008.

  5. Early Pregnancy Eugenic Screening Intervention of Birth Defects%孕期优生筛查对出生缺陷干预效果的影响分析

    Institute of Scientific and Technical Information of China (English)

    邹文霓; 王丽娟; 张盈; 吴玉璘

    2012-01-01

      Objective To investigate the maternal serum pregnancy-associated plasma protein-A, alpha-fetoprotein, beta-human chorionic gonadotrophin. Combination of B-ultrasound, amniotic fluid detection means for screening and diagnosis of Jiangsu province in an area of target diseases Down's syndrome, neural tube defects. Methods This screening using time-resolved fluorescence method for the determination of PAPPA the pregnant women, serum, AFP,β-HCG level, combined with a variety of related factors, risk assessment. Results 1807 cases of second trimester pregnant women receiving prenatal screening were screened in pregnancy high-risk 21-trisomy 18-body, neural tube defects in 110 cases, the positive rate of 6.09%; and screening of high risk pregnant women the positive rate increased with increasing maternal age. 110 cases of screening-positive pregnant women, 84 cases of pregnant women receiving amniotic fluid chromosome, check out chromosomal abnormalities in two cases, 21 of them-three-body one cases;18-one cases of trisomy;B ultrasound trance administered defect in one case (one cases of spina bifida), hydrocephalus one case, two cases of congenital heart disease. Underwent induction of labor, labor induction rate of 100%. Conclusion Take the detection of maternal serum pregnancy-related protein, alpha-fetoprotein, beta-human chorionic gonadotrophin level, combined with B ultrasound, amniotic fluid detection means screening for Down syndrome, neural tube defects, birth defects, to reduce its birth rate is important.%  目的 探讨检测孕妇血清中妊娠相关蛋白A(PAPPA)、甲胎蛋白(AFP)、绒毛膜促性腺激素(β-HCG)水平,结合B超检查、羊水检测等手段,对江苏省苏北某地区目标疾病唐氏综合征、神经管缺陷进行筛查

  6. Forensic Analysis of Windows Registry Against Intrusion

    Directory of Open Access Journals (Sweden)

    Haoyang Xie

    2012-03-01

    Full Text Available Windows Registry forensics is an important branch of computer and network forensics. Windows Registry is often considered as the heart of Windows Operating Systems because it contains allof the configuration setting of specific users, groups, hardware, software, and networks. Therefore, Windows Registry can be viewed as a gold mine of forensic evidences which could be used in courts. This paper introduces the basics of Windows Registry, describes its structure and its keys and subkeys thathave forensic values. This paper also discusses how the Windows Registry forensic keys can be applied in intrusion detection.

  7. Birth cohorts

    DEFF Research Database (Denmark)

    Andersen, Anne-Marie Nybo; Madsen, Mia

    2009-01-01

    ; provides practical guidance on how to set-up and maintain birth cohorts for completing family-based studies in life course epidemiology; describes how to undertake appropriate statistical analyses of family-based studies and correctly interpret results from these analyses; and provides examples that...

  8. On the Cooperation of Independent Registries

    CERN Document Server

    Miraz, Matteo

    2010-01-01

    Registries play a key role in service-oriented applications. Originally, they were neutral players between service providers and clients. The UDDI Business Registry (UBR) was meant to foster these concepts and provide a common reference for companies interested in Web services. The more Web services were used, the more companies started create their own local registries: more efficient discovery processes, better control over the quality of published information, and also more sophisticated publication policies motivated the creation of private repositories. The number and heterogeneity of the different registries - besides the decision to close the UBR are pushing for new and sophisticated means to make different registries cooperate. This paper proposes DIRE (DIstributed REgistry), a novel approach based on a publish and subscribe (P/S) infrastructure to federate different heterogeneous registries and make them exchange information about published services. The paper discusses the main motivations for the P...

  9. Study on birth defects in the perinatal in Haizhu District of Guangzhou from 2004 to 2008%广州市海珠区2004-2008年围产儿死亡出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    魏洁玲; 刘传勇; 袁瑷芹

    2010-01-01

    目的 了解广州市海珠区围产儿死亡病例中发生出生缺陷的种类及分布情况,探讨出生缺陷对围产儿死亡的影响.方法 数据来源于广州市各医院逐季上报的及汇总至省妇幼保健院的,本研究监测了2004年第四季度-2008年第三季度海珠区各所医院住院分娩孕28-w产后7d的围产儿死亡率和死亡围产儿中出生缺陷发生率.结果 监测广州市海珠区5年中围产儿48268例,围产儿死亡病例555例,围产儿死亡率为11.5‰,围产儿死亡中发生出生缺陷的220例,出生缺陷发生率为36.64%,其中胎儿水肿综合征、唇腭裂、脑积水、先天性心脏病和四肢畸形排在死亡围产儿出生缺陷发生的前5位.结论 出生缺陷是导致围产儿死亡的重要原因之一,应加强婚前生殖健康教育和医学检查,做好婚前保健,优生及孕产期保健,尽可能减少出生缺陷的发生.%Objective To investigate the types and distribution of perinatal death defects in Haizhu District of Guangzhou and look for of related factors birth defects.Methods The cases of perinatal were studied from the third quarter of 2004 to the third quarter of 2008 in most of hospitals in Haizhu District.The datas were from birth defects registration cards of Maternal and Child Health Hospital of Guangdong Province,which included the perinatal birth informations of every quarters from all hospitals.Results 48248 cases of perinatal of Haizhu District were monitored in this study.There are 555 cases of perinatal death and the perinatal mortality rate was 11.5‰.There were222 cases of perinatal birth defects of all perinatal deaths and the birth defect rate of perinatal death was 36.64%.Hydrops fetalis syndrome,cleft lip and palate,hydrocephalus,congenital heart disease and limb deformities are the top five defects in a variety of cases.Conclusion Birth defects is one of the major causes of perinatal death.It is important for us to promote reproduetive health

  10. The Danish National Prescription Registry

    DEFF Research Database (Denmark)

    Kildemoes, Helle Wallach; Toft Sørensen, Henrik; Hallas, Jesper

    2011-01-01

    Introduction: Individual-level data on all prescription drugs sold in Danish community pharmacies has since 1994 been recorded in the Register of Medicinal Products Statistics of the Danish Medicines Agency. Content: The register subset, termed the Danish National Prescription Registry (DNPR...... on the dispensed drug. Conclusion: The possibility of linkage with many other nationwide individual-level data sources renders the DNPR a very powerful pharmacoepidemiological tool...

  11. When Your Baby Has a Birth Defect

    Science.gov (United States)

    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which ... These are abnormalities of structure, function, or body chemistry that will require medical or surgical care or ...

  12. National Birth Defects Prevention Study (NBDPS)

    Science.gov (United States)

    ... do not know whether the amounts of pollution women are exposed to can affect their unborn babies. NBDPS researchers found that higher exposure to air pollutants related to car traffic, specifically nitrogen dioxide, was more common among mothers ...

  13. What Are the Types of Birth Defects?

    Science.gov (United States)

    ... fee-nill-key-toe-NURR-ee-uh ) and hypothyroidism ( hahy-puh-THAHY-roi-diz-uhm ). Degenerative disorders. ... 30/2012 Related A-Z Topics Cerebral Palsy Congenital Adrenal Hyperplasia (CAH) Down Syndrome All related topics ...

  14. March of Dimes Birth Defects Foundation

    Science.gov (United States)

    ... to prevent bites. Use a condom to prevent sexual transmission. 5 If you suspect, then connect: call your health care provider if you are at risk of infection. Trending Share your story Connect with other family ...

  15. Long-term follow-up of cognitive outcome after breech presentation at birth

    DEFF Research Database (Denmark)

    Sørensen, Henrik Toft; Steffensen, Flemming Hald; Olsen, Jørn;

    1999-01-01

    Studies of long-term consequences of birth in breech presentation are sparse. Therefore, we conducted a cohort study linking birth registry data with data collected during evaluation for military service in 4,298 conscripts born between 1973 and 1976. The cognitive functions were measured...

  16. Lower Birth Weight and Diet in Taiwanese Girls More than Boys Predicts Learning Impediments

    Science.gov (United States)

    Lee, Meei-Shyuan; Huang, Lin-Yuan; Chang, Yu-Hung; Huang, Susana Tzy-Ying; Yu, Hsiao-Li; Wahlqvist, Mark L.

    2012-01-01

    Possible links between lower birth weight, childhood diet, and learning in Taiwan are evaluated. The population representative Elementary School Children's Nutrition and Health Survey in Taiwan 2001-2002 and the national birth registry were used to examine school and social performance using the modified Scale for Assessing Emotional Disturbance…

  17. Observing and analyzing of perinatal birth defect in Zhongshan city in decade%中山地区2000年~2008年围产儿出生缺陷监测分析及干预措施

    Institute of Scientific and Technical Information of China (English)

    王莹; 袁春雷; 杨孜; 彭学鸣; 张翠梅; 王冬娥

    2011-01-01

    Objective: To Evaluate the occurrence status of birth defects from 2000 to 2008 in Zhongshan city, Guangdong province by means of reviewing and analyzing some of the cases. Provide bases for service of health to draw up intervention measures.Methods: Analyzing the perinatal birth defect data from 2000 to 2008 in Zhongshan city, Guangdong province by means of reviewing.Results: From 2000 to 2008, the mean ratio of perinatal birth defect is 189. 7 per ten thousand. This presents an upward trend. The first five birth defect were: congenital heart disease, neural tube malformation, combined or excessive fingers or toes (polydactyly),α - Mediterranean - anaemia. Conclusion: In order to depress perinatal birth defect rate, we should pay more attention in not only to the work of education of the knowledge of health care before marriage or pregnancy, but also to the work of examination and diagnosis before delivery.%目的 通过回顾性分析中山市围产儿出生缺陷水平变化情况,探讨其影响因素,为卫生行政部门制订决策提供依据.方法 对2000年至2008年中山市国产儿出生缺陷资料进行分析.结果 2000年至2008年国产儿平均出生缺陷发生率为102/万,呈上升趋势.出生缺陷发生前5位的是:先天性心脏病、唇腭裂、神经管畸形、并多指(趾)、α-地中海贫血.结论 应进一步加强宣教、加强提高产前筛查水平及产前诊断,降低围产儿出生缺陷发生率.

  18. The prevalence at birth of congenital malformations in the city of Ozyorsk located near the nuclear complex Mayak production association

    Energy Technology Data Exchange (ETDEWEB)

    Petrushkina, N. P.; Koshurnikova, N. A.; Okatenko, P. V.

    2004-07-01

    For many years possible genetic effects of exposure to ionizing radiation have been a subject of interest and concern, but data from studies of the risk of radiation-induced hereditary effects in humans are limited. the most extensive human studies of genetic effects were those conducted on the Japanese. A-bomb survivors. In These studies in investigators examined the association of various levels of radiation exposure and several different endpoints, including major congenital defects, stillbirth, death during the first week of life, survivals, and sex ratio and Down's syndrome (8, (14-16). Although associations of these outcomes with radiation exposure were in the positive direction, none were close to statistical significance. Only teratogenic effects of in utero exposure at Hiroshima and Nagasaki, microcephaly and mental retardation, have been observed (8, (10, 16)). Of most interest is possible association of congenital malformations (CMs) with parental occupational radiation exposure. Determination of the role of parental occupational exposure in induction of CMs in children is necessary to evaluate reliability of radiation protection standards Epidemiological studies conducted on the basis of Registries of children who were born in regions located near a nuclear complex may be useful for such evaluation. It is preferable to carry out such studies on the basis of population registries, since long follow-up in large populations allows to reveal increased frequency of even very rare forms of congenital abnormalities. In a case-control study of association of parental occupational exposure due to Hanford Nuclear Site and risk of CMs in their offspring there was no evidence of such an association (12, 13). Our investigation is conducted on the basis of the basis of the Registry of children of Ozyorsk. The whole Registry includes all children with 1948-1988 birth years show were born or-came to town at the age of 0-14 years, and were residents of these towns

  19. 青龙满族自治县育龄妇女预防出生缺陷知识知晓情况现状及影响因素分析%Analysis of status and influence factors of women of childbearing age be-ing aware of birth defects knowledge in Qinglong Manchu Autonomous County

    Institute of Scientific and Technical Information of China (English)

    王民

    2015-01-01

    目的 了解青龙满族自治县育龄妇女预防出生缺陷知识知晓情况现状及影响因素,以便有针对性地开展出生缺陷预防工作,降低出生缺陷发生率. 方法 随机抽取青龙满族自治县2014年1月~2015年7月符合生育政策、计划怀孕并参加免费孕前优生健康检查的1200名育龄妇女,使用自行设计的统一调查问卷,进行预防出生缺陷知识知晓情况自填式问卷调查. 结果 育龄妇女获取预防出生缺陷知识的途径形式单一,依次为书籍杂志、医院、网络等,预防出生缺陷知识的总知晓率仅为68%;影响育龄妇女预防出生缺陷知识知晓情况的因素为年龄、文化水平、职业、经济条件等.其中20~32岁年龄段的人群高于33~39岁;大专及以上文化程度的人群高于其他文化长度的人群; 有固定工作的人群高于无固定工作的人群; 经济收入较高的人群高于经济收入较低的人群(P<0.01). 结论 青龙满族自治县育龄妇女预防出生缺陷知识知晓率较低,应引起有关部门重视,应根据影响育龄妇女预防出生缺陷知识知晓情况的因素,认真开展多种渠道的健康教育宣传,提高育龄妇女预防出生缺陷知识的知晓率,有效降低出生缺陷发生的风险.%Objective To know the status and influence factors of women of childbearing age being aware of birth de-fect knowledge in Qinglong Manchu Autonomous County to carry out targetedly the prevention work of birth defect and reduce the incidence rate of birth defect. Methods 1200 women of childbearing age who had met the requirement for pregnancy and were planning to have a baby and had participated in the free pre-pregnancy health examination for eu-genics from January 2014 to July 2015 were randomly selected.Self-designed and self-administrated unified question-naire was adopted to investigate the status of awareness of birth defect prevention knowledge. Results Women of child-bearing age got to

  20. Clara's birth.

    Science.gov (United States)

    Thorens, S; Richer, D; Bel, A; Bel, B

    1999-01-01

    Advocacy for homebirth is based on the strong assumption that birthing is a physiological process and does not require medical interventions unless things turn "wrong." Let us assume that something might always go wrong, for instance during Clara's birth when the placenta was still retained after three hours. What needs to be done? The moment the midwife entered the house she was endowed with a responsibility for any problem caused by her failure to give proper guidance. With this weight on her shoulder, and according to her training and experience, there was no other way for her than to suggest an intervention regarding the placenta. The two midwives, B, and C., might not agree on risk estimations, the nature of the intervention, whether it should be performed at home or in a hospital. The estimation of abnormalities, evaluation of risks and the procedures with which to handle them are the main practical difference between classic obstetrics and non-interventionist midwifery--by analogy, between allopathy and naturopathy. The rest (positive thinking) is basically literature. A delivery will not remain normal just because we decide it "must" be physiological. Dr. Barua, a professor of obstetrics in Pondicherry, pointed out that normal deliveries are rare--fewer than 10 percent in South India. What we have instead is either pathological or "natural" deliveries in which regenerative processes take care of abnormal situations. Unless she has developed sensitive hands, a birth assistant or midwife must rely on monitoring procedures to evaluate deviations from the normal process. Even with the greatest care, these procedures are intrusive in that they disconnect the parturient from her own sensations. While successful unattended homebirth stories emphasise the extraordinary power and sensitivity of a birthing woman, the whole dream seems to collapse in abnormal or pathological cases. It would have collapsed for Sonia as well, had she not discarded negative suggestions

  1. Evaluation of institutional cancer registries in Colombia.

    Science.gov (United States)

    Cuervo, L G; Roca, S; Rodríguez, M N; Stein, J; Izquierdo, J; Trujillo, A; Mora, M

    1999-09-01

    The four primary objectives of this descriptive study were to: 1) design a quality-measurement instrument for institutional cancer registries (ICRs), 2) evaluate the existing ICRs in Colombia with the designed instrument, 3) categorize the different registries according to their quality and prioritize efforts that will efficiently promote better registries with the limited resources available, and 4) determine the institution with the greatest likelihood of successfully establishing Colombia's second population-based cancer registry. In 1990 the National Cancer Institute of Colombia developed 13 institution-based cancer registries in different Colombian cities in order to promote the collection of data from a large group of cancer diagnostic and treatment centers. During the first half of 1997, this evaluation reviewed 12 registries; one of the original 13 no longer existed. All of the Colombian institutions (hospitals) that maintain institution-based cancer registries were included in the study. At each institution, a brief survey was administered to the hospital director, the registry coordinator, and the registrar (data manager). Researchers investigated the institutions by looking at six domains that are in standard use internationally. Within each domain, questions were developed and selected through the Delphi method. Each domain and each question were assigned weights through a consensus process. In most cases, two interviewers went to each site to collect the information. The university hospitals in Cali, Pereira, and Medellín had substantially higher scores, reflecting a good level of performance. Four of the 12 institutions had almost no cancer registry work going on. Five of the 12 hospital directors considered that the information provided by the cancer registries influenced their administrative decisions. Three of the registries had patient survival data. Four of the institutions allocated specific resources to operate their cancer registries; in the

  2. The origin of congenital heart defects and the epigenetic programming of the healthy child

    NARCIS (Netherlands)

    S.A. Obermann-Borst (Sylvia)

    2013-01-01

    textabstractBirth defects are a global burden affecting 7% of births worldwide. Congenital heart defects (CHD) are the most common congenital malformation with approximately 1 million children born each year. It is not only the most frequent group of birth defects in human, but also the leading caus

  3. 降低出生缺陷关键技术及干预措施的研究%Study on key techniques and intervention in reducing birth defects

    Institute of Scientific and Technical Information of China (English)

    朱宝生; 林克萍; 陈红; 李苏云; 苏洁; 卢晓红; 贺静; 朱姝; 焦存仙; 章锦曼; 唐新华; 陶滢

    2011-01-01

    低风险孕妇的妊娠结局,未发现活产儿中有上述目标疾病的患儿。血清学筛查对DS的检出率为84%( 27/32),假阳性率为6.153%( 1702/27 660)。结论孕前及孕早期补充叶酸可降低出生缺陷风险,但育龄期妇女主动补充叶酸者仅占1/3;血清学筛查可高效检出DS、ES和NTD;遗传咨询对诊断高风险和遗传病家族史的人群至关重要;以血清学筛查和产前诊断为关键技术,与常规产前检查相结合,可以降低严重出生缺陷的发生率,应成为我国的新型围产保健策略。%ObjectiveTo investigate key techniques and intervention in reducing birth defects. Method Down's syndrome (DS), trisomy-18 (Edwards syndrome, ES), neural tube defects (NTD), Duchenne muscular dystrophy (DMD), spinal muscular atrophy (SMA), thalassemia, and glucose-6-phosphate dehydrogenase deficiency (G6PD) were chosen as target disease. From Jan. 2007 to Dec. 2009, the condition of intake folie acid were investigated in 5004 pregnant women in Panlong District and Wuhua District of Kunming City. All of the 27 660 pregnant women undergoing prenatal examination were enrolled into the study from the First People's Hospital of Yunnan Province, the Second People's Hospital of Yunnan Province, the First People's Hospital of Qujing City, the Second People's of Qujing City, Qujing Women and Children's Hospital, People's Hospital of Lincang City, Kunming Maria Women's Hospital, Maternal and Infant's Care Unit of Panlong District of Kunming City, Maternal and Infant's Hospital of Dali City. The screening was performed on serum of those pregnant women at 8 -20 +6 gestational weeks. Prenatal cytogenetic analysis and fetal ultrasonogrspy were performed on the high risk or indicated women after genetic counseling. DNA analysis was administered on those women with family or childbearing history of DMD,SMA, thalassemia, or G6PD. Outcome of pregnancy was followed up to evaluate the effect of

  4. [Current registry studies of acute ischemic stroke].

    Science.gov (United States)

    Veltkamp, R; Jüttler, E; Pfefferkorn, T; Purrucker, J; Ringleb, P

    2012-10-01

    Study registries offer the opportunity to evaluate the effects of new therapies or to observe the consequences of new treatments in clinical practice. The SITS-MOST registry confirmed the validity of findings from randomized trials on intravenous thrombolysis concerning safety and efficacy in the clinical routine. Current study registries concerning new interventional thrombectomy techniques suggest a high recanalization rate; however, the clinical benefit can only be evaluated in randomized, controlled trials. Similarly, the experiences of the BASICS registry on basilar artery occlusion have led to the initiation of a controlled trial. The benefit of hemicraniectomy in malignant middle cerebral artery infarction has been demonstrated by the pooled analysis of three randomized trials. Numerous relevant aspects are currently documented in the DESTINY-R registry. Finally, the recently started RASUNOA registry examines diagnostic and therapeutic aspects of ischemic and hemorrhagic stroke occurring during therapy with new oral anticoagulants.

  5. A cohort study on the relationship between serum folic acid of pregnant women during the first trimester of pregnancy and onset of fetal birth defects%妊早期妇女血清叶酸水平与胎儿出生缺陷发病关系的队列研究

    Institute of Scientific and Technical Information of China (English)

    王珊; 潘新娟; 余增丽

    2012-01-01

    Objective: To explore the relationship between serum folic acid of pregnant women and onset of fetal birth defects. Methods: The pregnant women who received prenatal examination and met the inclusion criteria in the hospital from April 2007 to April 2010 were selected as respondents, then they were divided into group A (never taking folic acid before and during pregnancy) , group B (taking folic acid after pregnancy) , and group C ( taking folic acid before and after pregnancy) , the serum levels of folic acid in the three groups were compared; all the pregnant women were followed up till six months after birth, the pregnancy outcome was surveyed, and the incideuees of birth defects in the three groups were compared. Results: The serum level of folic acid in group A was significantly lower than those in group B and group C, the mean serum level of folic acid in group C was higher than that in group B ( P < 0. 05 ) . The incidence of fetal birth defects in group A was significantly higher than those in group B and group C ( P <0. 05) . Compared with pregnant women taking folic acid regularly during pregnancy, the relative risk ratio of fetuses with birth defects in the pregnant women not taking folic acid regularly was 3. 48 (2. 02/0. 58) , increasing by 2. 48 times. Conclusion: The folic acid level of pregnant women during the first trimester of pregnancy is related to birth defects, taking folic acid during pregnancy can reduce the risk of birth defects.%目的:探讨孕妇血清叶酸水平与胎儿出生缺陷发病的关系.方法:选择2007年4月~ 2010年4月在开封市妇产医院进行产检的、符合纳入标准的孕妇为调查对象,按其服用叶酸的情况分为A组(孕前、孕期从未口服叶酸)、B组(孕后口服叶酸)、C组(孕前、孕后均口服叶酸),比较三组血清叶酸水平;对其进行随访至胎儿出生6个月,调查出生结局,比较三组出生缺陷发生情况.结果:A组的血清叶酸平均水平明显低于B

  6. Tools and data services registry

    DEFF Research Database (Denmark)

    Ison, Jon; Rapacki, Kristoffer; Ménager, Hervé;

    2016-01-01

    a spectrum of scientific disciplines. The corpus of documentation of these resources is fragmented across the Web, with much redundancy, and has lacked a common standard of information. The outcome is that scientists must often struggle to find, understand, compare and use the best resources for the task...... is assured by a curation effort driven by and tailored to local needs, and shared amongst a network of engaged partners.As of September 2015, the registry includes 1633 resources, with depositions from 91 individual registrations including 40 institutional providers and 51 individuals. With community support...

  7. Birth order and Risk of Childhood Cancer: A Pooled Analysis from Five U.S. States

    OpenAIRE

    Von Behren, Julie; Spector, Logan G.; Mueller, Beth A.; Carozza, Susan E.; Chow, Eric J.; Fox, Erin E; Horel, Scott; Johnson, Kimberly J.; McLaughlin, Colleen; Puumala, Susan E.; Ross, Julie A; Reynolds, Peggy

    2010-01-01

    The causes of childhood cancers are largely unknown. Birth order has been used as a proxy for prenatal and postnatal exposures, such as frequency of infections and in utero hormone exposures. We investigated the association between birth order and childhood cancers in a pooled case-control dataset. The subjects were drawn from population-based registries of cancers and births in California, Minnesota, New York, Texas, and Washington. We included 17,672 cases less than 15 years of age who were...

  8. 武昌地区13家助产机构2006至2009年围生儿出生缺陷分析%Birth Defects from 13 Midwifery Institution During the Year of 2006-2009 in Wuchang Region

    Institute of Scientific and Technical Information of China (English)

    卢媛; 李莹; 刘婷婷

    2011-01-01

    Objective To explore the situation , influencing factors, prognosis and diagnosis of the birth default in Wuchang region. Methods The results from 13 hospital studies on 28 542 births were analyzed by retrospective and statistics study from 2006 to 2009. Results 316 birth defects in a total of 28 542 births were monitored from 2006 to 2009, the birth defects rate was 1. 11 % (316/28 542). The first four leading diseases were congenital heart disease, anomaly of locomotor, digestive system and neurocanal.The influence factors of parturients' social relation on the birth default were family income, parturients' age and educational background. Compare to family monthly income less than 4000 yuan group, birth defects rate in family monthly income more than 8000 Renming bi yuan group was decreased (x2 = 10. 91, P<0.01). There had statistical significant difference of birth defects rate between the age from 25 to 35 group and the rest age group(P<0. 05). Also there had significant difference of birth defects rate between high school/college group and other educational background group(P<0. 05). The death rates of birth default (43.3%) was 101 times higher than non birth default 0. 43% (123/28 542). 37. 0% (117/316) cases were confirmed in prenatal diagnosis, which was the mainly method to diagnose of birth default. Conclusion The birth default has high death rates and influence by parturients. In order to increase the prenatal diagnosis of birth default and decrease the birth defaults rate, we should take measures to educate the parturients and avoid the high risk factors.%目的 探讨武昌地区助产机构围生儿出生缺陷发生状况、影响因素、确诊手段及预后.方法 按照对武昌地区13家助产机构2006年10月1日至2009年09月31日分娩的28 542例围生儿中316例(单胎)出生缺陷围生儿监测资料进行回顾性分析,对可能导致围生儿出生缺陷的相关因素包括家庭收入、产妇年龄、产妇学

  9. Private provider participation in statewide immunization registries

    Directory of Open Access Journals (Sweden)

    Cowan Anne E

    2006-02-01

    Full Text Available Abstract Background Population-based registries have been promoted as an effective method to improve childhood immunization rates, yet rates of registry participation in the private sector are low. We sought to describe, through a national overview, the perspectives of childhood immunization providers in private practice regarding factors associated with participation or non-participation in immunization registries. Methods Two mailed surveys, one for 264 private practices identified as registry non-participants and the other for 971 identified as registry participants, from 15 of the 31 states with population-based statewide immunization registries. Frequency distributions were calculated separately for non-participants and participants regarding the physician-reported factors that influenced decisions related to registry participation. Pearson chi-square tests of independence were used to assess associations among categorical variables. Results Overall response rate was 62% (N = 756. Among non-participants, easy access to records of vaccines provided at other sites (N = 101, 68% and printable immunization records (N = 82, 55% were most often cited as "very important" potential benefits of a registry, while the most commonly cited barriers to participation were too much cost/staff time (N = 36, 38% and that the practice has its own system for recording and monitoring immunizations (N = 35, 37%. Among registry participants, most reported using the registry to input data on vaccines administered (N = 326, 87% and to review immunization records of individual patients (N = 302, 81%. A minority reported using it to assess their practice's immunization coverage (N = 110, 29% or generate reminder/recall notices (N = 54, 14%. Few participants reported experiencing "significant" problems with the registry; the most often cited was cost/staff time to use the registry (N = 71, 20%. Conclusion Most registry participants report active participation with few

  10. Windows registry forensics advanced digital forensic analysis of the Windows registry

    CERN Document Server

    Carvey, Harlan

    2011-01-01

    Harlan Carvey brings readers an advanced book on Windows Registry - the most difficult part of Windows to analyze in forensics! Windows Registry Forensics provides the background of the Registry to help develop an understanding of the binary structure of Registry hive files. Approaches to live response and analysis are included, and tools and techniques for postmortem analysis are discussed at length. Tools and techniques will be presented that take the analyst beyond the current use of viewers and into real analysis of data contained in the Registry. This book also has a DVD containing tools, instructions and videos.

  11. 杭州市余杭区人群基础出生缺陷普查及高危因素研究%Prevalence of birth defects and related risk factors among children age 0 - 3 years old in Yuhang District

    Institute of Scientific and Technical Information of China (English)

    王撬撬; 周任婧; 陈琴芳; 刘小芹; 袁伟; 王波

    2012-01-01

    Objective: To know about the prevalence of birth defects in Yuhang District of Hangzhou City and to explore the risk factors related to birth defects. Methods; A total of 21 713 children aged 0-3 years old were investigated in Yuhang District. A case - control study was used to determine potential risk factors. Results: A total of 365 children with birth defects were found. Low income, poor health during pregnancy, strenuous work for women three months before pregnancy and taking medicine during pregnancy could increase the risk of birth defects. Moreover, experience of second - smoking exposure for pregnant women, spouses'poor health status and elder age (above 35 years old) also contributed to birth defects. Conclusion; It is necessary to prevent birth defects by improving the knowledge about health care among pregnant women and providing primary prevention strategy.%目的:获得余杭区出生缺陷基本信息,寻找出生缺陷高危因素,为出生缺陷病因学研究及防治措施提供可靠依据.方法:对2007年6月1日~2010年5月31日分娩(孕周≥28周),在余杭区进行出生申报的21 713名0~3岁婴幼儿进行出生缺陷信息收集.根据基线调查结果,采用1:2病例对照研究方法,收集出生缺陷组及对照组孕母人口学特征、孕前及妊娠期精神情况、药物暴露史等信息.结果:共筛查出生缺陷儿365名.出生缺陷高危因素分析发现,家庭收入低、母亲健康状况差、孕前3个月工作强度高、精神压力大和妊娠期间服用药物等因素是余杭地区出生缺陷发生的高危因素.此外,孕妇妊娠期存在被动吸烟情况、配偶健康状况差及生育年龄>35岁也会增加出生缺陷发生危险.结论:进一步加强优生优育宣教,提高育龄妇女自我保健意识,深化出生缺陷一级预防干预策略,以降低出生缺陷发生风险.

  12. 广东省深圳市龙岗区孕期妇女出生缺陷相关知信行调查%Survey on knowledge, attitudes and practices about birth defects among pregnant women in Longgang District of Shenzhen, Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    张绍强; 廖瑞容; 张玲; 陈文英; 夏洪波

    2012-01-01

    Objective To determine knowledge, attitude and practice about birth defects among pregnant women, and provide reasonable suggestions to improve perinatal health services and health education. Methods Stratified. Random sampling method was used to select 86 of pregnant women from three streets of Longgang District, Shenzhen City as participants in this study. Results There were 91. 86% of pregnant women had heard of birth defect before pregnancy. 80. 77% of them women said they supported the policy of distributing folic acid free by government 50% of respondents conducted premarital medical examination. In higher education level group, the participation rate in premarital medical examination of couples was significantly higher than that with low literacy. Moreover, pregnant women with higher literacy would pay more attention to prenatal care, prevention of birth defects and folic acid knowledge. The pregnant women with higher per capita monthly income of family would have higher degree of attention to you should get rid of contacting with pesticides/paint and reduce the opportunities of touching cats and dogs. The sources of knowledge about prevention birth defects before pregnancy were mainly from doctors and communication materials, with the proportion of 30.23% and 29.07% , respectively. Conclusion The findings showed that the level of general knowledge about birth defect and folic acid was relatively high among pregnant women in Longgang District. Literacy and per capita monthly income of family are influencing factors on knowledge about birth defects among pregnant women.%目的 了解广东省深圳市龙岗区孕期妇女对预防出生缺陷的知信行情况,为进一步完善围产期保健服务及健康教育工作提供合理化建议.方法 采用分层随机抽样方法,抽取86名孕期妇女进行面对面问卷调查.结果 91.86%的孕期妇女在怀孕前听说过出生缺陷,80.77%的孕期妇女对政府免费发放

  13. Service registry design: an information service approach

    NARCIS (Netherlands)

    Ferreira Pires, Luis; Oostrum, van Arjen; Wijnhoven, Fons; Wang, J.

    2010-01-01

    A service registry is a Service-Oriented Architecture (SOA) component that keeps a ‘catalogue’ of available services. It stores service specifications so that these specifications can be found by potential users. Discussions on the design of service registries currently focus on technical issues, wh

  14. 50 CFR 600.1410 - Registry process.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Registry process. 600.1410 Section 600.1410 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... United States § 600.1410 Registry process. (a) A person may register through the NMFS web site at...

  15. The Western Denmark Cardiac Computed Tomography Registry

    DEFF Research Database (Denmark)

    Nielsen, Lene Hüche; Nørgaard, Bjarne Linde; Tilsted, Hans Henrik;

    2015-01-01

    BACKGROUND: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark. OBJECTIVE: We...

  16. Central registry in psychiatry: A structured review

    Directory of Open Access Journals (Sweden)

    Jyoti Prakash

    2014-01-01

    Full Text Available Background: Central registry in psychiatry is being practiced in few countries and has been found useful in research and clinical management. Role of central registry has also expanded over the years. Materials and Methods: All accessible internet database Medline, Scopus, Embase were accessed from 1990 till date. Available data were systematically reviewed in structured manner and analyzed. Results: Central registry was found useful in epidemiological analysis, association studies, outcome studies, comorbidity studies, forensic issue, effective of medication, qualitative analysis etc., Conclusion: Central registry proves to be effective tool in quantitative and qualitative understanding of psychiatry practice. Findings of studies from central registry can be useful in modifying best practice and evidence based treatment in psychiatry.

  17. Prevalence, prenatal diagnosis and clinical features of oculo-auriculo-vertebral spectrum: a registry-based study in Europe.

    LENUS (Irish Health Repository)

    Barisic, Ingeborg

    2014-01-08

    Oculo-auriculo-vertebral spectrum is a complex developmental disorder characterised mainly by anomalies of the ear, hemifacial microsomia, epibulbar dermoids and vertebral anomalies. The aetiology is largely unknown, and the epidemiological data are limited and inconsistent. We present the largest population-based epidemiological study to date, using data provided by the large network of congenital anomalies registries in Europe. The study population included infants diagnosed with oculo-auriculo-vertebral spectrum during the 1990-2009 period from 34 registries active in 16 European countries. Of the 355 infants diagnosed with oculo-auriculo-vertebral spectrum, there were 95.8% (340\\/355) live born, 0.8% (3\\/355) fetal deaths, 3.4% (12\\/355) terminations of pregnancy for fetal anomaly and 1.5% (5\\/340) neonatal deaths. In 18.9%, there was prenatal detection of anomaly\\/anomalies associated with oculo-auriculo-vertebral spectrum, 69.7% were diagnosed at birth, 3.9% in the first week of life and 6.1% within 1 year of life. Microtia (88.8%), hemifacial microsomia (49.0%) and ear tags (44.4%) were the most frequent anomalies, followed by atresia\\/stenosis of external auditory canal (25.1%), diverse vertebral (24.3%) and eye (24.3%) anomalies. There was a high rate (69.5%) of associated anomalies of other organs\\/systems. The most common were congenital heart defects present in 27.8% of patients. The prevalence of oculo-auriculo-vertebral spectrum, defined as microtia\\/ear anomalies and at least one major characteristic anomaly, was 3.8 per 100 000 births. Twinning, assisted reproductive techniques and maternal pre-pregnancy diabetes were confirmed as risk factors. The high rate of different associated anomalies points to the need of performing an early ultrasound screening in all infants born with this disorder.European Journal of Human Genetics advance online publication, 8 January 2014; doi:10.1038\\/ejhg.2013.287.

  18. Birth outcome in women with ulcerative colitis and Crohn's disease, and pharmacoepidemiological aspects of anti-inflammatory drug therapy

    DEFF Research Database (Denmark)

    Nørgård, Bente Mertz

    2011-01-01

    prescription Database, the Danish National Hospital Discharge Registry, the Danish Medical Birth Registry, and review of selected medical records. After exposure to sulfasalazine during pregnancy our data suggest. No significantly increased overall relative risk of congenital abnormalities and no significantly...... with similar underlying diseases. It is difficult to rule out an influence of uncontrolled confounding. These were the first published data from a controlled observational study on exposed women with chronic inflammatory bowel disease. After preconceptional paternal use of azathioprine/6-mercaptopurine our...... National Hospital Discharge Registry, the nationwide Danish Prescription Database and the Danish Medical Birth Registry. Furthermore, birth outcomes are examined in Crohn's disease women with disease activity during pregnancy, based on data from review of hospital records, the Danish National Hospital...

  19. Research on Difference in High-risk Birth Defect Epidemic Cause between Zhuang People and Han People in Nanning%南宁壮族与汉族高发出生缺陷流行病因差异研究

    Institute of Scientific and Technical Information of China (English)

    蒋武; 覃頔; 黄永全; 韦金露; 言京礼

    2016-01-01

    Objective To know whether there is a national difference in the incidence rate between different high-risk birth defects in Nanning and study its causes, and summarize the strategies of reducing the incidence rate of birth defects accord-ing to various risk factors and realize the sound child rearing in Nanning region. Methods The exposed risk factors of par-ents of 1274 perinatal infants with birth defects in Nanning were given 1 : 1 matched case-control study, the relevant influ-ence factors were studied and analyzed, and the case data base was established by Excel, and then the data was analyzed and treated by SPSS16.0 statistical software. Results In the defect group, 574 cases were Zhuang people, 666 cases were Han people, the incidence rates of congenital heart disease, cleft palate , harelip and cleft palate, hypospadias and gas-troschisis in Han people were higher than those in Zhuang people, the incidence rates of harelip, congenital hydrocephalus, neural tube defect, fetal edema syndrome, esophageal a-tresia or stenosis, anorectum atresia or stenosis and con-genital diaphragmatic hernia in Zhuang people were high-er than those in Han people, and the differences had sta-tistical significance, living in the polluted environment, exposure to radiation or toxic chemicals during pregnancy, medication without guidance of doctors during pregnancy, age of pregnant women more than 35, congenital disease family history, chemical exposure history of fathers, smoking and alcohol history of fathers, nutrition of pregnant women and dysthymia during pregnancy were related to the birth defects, and all of them were risk factors of birth defects. Conclusion There is a difference in the high-risk birth defect epidemic cause be-tween Zhuang people and Han people in Nanning with national specificity, the intervention in predicting birth defects in our region can be conducted from the aspects of environment, bad living habits, vocational factor and mental factor to reduce

  20. CDC WONDER: Births

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Births (Natality) online databases in CDC WONDER report birth rates, fertility rates and counts of live births occurring within the United States to U.S....

  1. 中国30个县(市)1993~2000年神经管畸形在出生人群中的患病率及变动趋势分析%Prevalence of neural tube defects at birth in 30 counties and cities of China, 1993-2000

    Institute of Scientific and Technical Information of China (English)

    叶荣伟; 李松; 郑俊池; 洪世欣; 陈新; 王太梅; 任爱国; 王丽娜; 李竹

    2002-01-01

    Objective:To describe the prevalence rates of neural tube defects (NTD) and yearly trends (1993-2000) in China. Methods: All the data were obtained from the Birth Defects Surveillance System in thirty counties/cities of China. The calculation of NTD prevalence rates and time trend analyses were based on the data for live (L) and stillbirths (S) only, the denominator used was total births (L+S). Linear regression analysis of the prevalence rate over years has been used to measure time trends. Results: In the period of 1993-2000, there were 1 264 neural tube defects among 1 189 126 total births in 30 counties/cities in China. The overall neural tube defects rate was 10.63 per 10000 births, and rates were higher (18.99 per 10 000 births) in the year 1993, lower (6.05 per 10 000 births) in 1998. The prevalence rates of anencephaly, spina bifida and encephalocele were 4.71,4.39 and 1.53 per 10 000 births respectively. Of all index NTD cases, anencephaly and spina bifida were most frequent, making up 44.3% and 41.3%, and encephalocele represented 14.4%. The stillbirth proportion was 69.3% over all index NTD cases, 95.4% in anencephaly cases, 43.7% in spina bifida, and 62.6% in encephalocele cases. Linear trend analysis indicated a significant decline for NTD rate (F=11.818, β=-0.814,P=0.014). Analysis by specific defect showed significant declines for the rates of anencephaly (P=0.004) and spina bifida (P=0.026), but no significant annual variation of encephalocele (P=0.227). Results of comparing with data reported from other surveillance systems (1994-1999) showed that the highest NTD rate (9.41 per 10000 births) was seen in China, nearly7 times the lowest rate (1.44 per 10000 births) in England and Wales. Conclusion: The overall neural tube defects rate in 30 counties/cities of China presented a significant downward trend between 1993 and 2000, and China still had the higher neural tube defects prevalence. %目的:描述中国30个县(市)1993

  2. RETROSPECTIVE CLINICAL ANALYSIS OF STILL BIRTH AND NEONATAL DEATHS

    Directory of Open Access Journals (Sweden)

    Uttam

    2014-03-01

    Full Text Available : OBJECTIVE: Aim was to evaluate clinical and associated risk factors for still births and neonatal deaths at tertiary health care centre. METHODS: A retrospective analytical study of new born at birth conducted at tertiary health care centre for three consecutive years. Demographic variables, status of new born at birth, NICU care and neonatal causes of death were analyzed. RESULTS: There were 1072,990,995 births for 2011, 2012, and 2013 year respectively Still births were 30, 36 and 41 and newborn deaths were 15,8,15 for three consecutive years. Mean age of mother was 25.35 yrs standard deviation 4.4. 82 % of still births were preterm. Maximum 67% of still births birth weight was less than 1.5 kg. NICU admission included 51% full term neonate, 44% preterm and 5% post term neonate. Maximum (51% NICU admissions neonatal birth weight was less < 1.5 kg.79% of dead neonates were preterm. Life threatening congenital defects was seen in 26%. Cause of death birth asphyxia 37% hyaline membrane disease 15%. CONCLUSION: Statistically significant mean gestational age of baby with mother was 38.26 weeks (SD 2.260, NICU neonates 36.70 weeks (SD 3.3 and still births 31.34 weeks (SD 4.6. Maternal urinary tract infection, Hypertensive diseases, diabetes mellitus were major reasons for stillbirths. Neonatal mortality from 26% reduced to 8% with increasing birth weight. Major neonatal deaths are because of birth asphyxia, congenital defects. Low Birth Weight and prematurity were overlapping factor for neonatal death. Still birth rate was 35; perinatal mortality rate was 44/1000 live births. Early neonatal mortality rate & Total neonatal mortality rate was 12 /1000 live births each

  3. Urban and rural difference and educational difference of cognition degree of birth defect prevention in uygur autonomous region%维吾尔族聚居区出生缺陷预防认知度的城乡区别及文化差异

    Institute of Scientific and Technical Information of China (English)

    杨涛

    2016-01-01

    Objective To summarize the relationship of geography and education and cognition degree of birth defect prevention in Uygur Autonomous Region investigated in Urumqi, Uygur Autonomous Region of Xinjiang from January 2006 to July 2013. Methods Statistics of 322 children with birth defects from January 2006 to July 2013 in Urumqi, Uygur Autonomous Region of Xinjiang were summarized. And it was received combined analysis with geography and education of pregnant women to explore the relationship of geography and education and cognition degree of birth defect prevention. Results The awareness rates of unban pregnant women with the high education of at least college about pregnancy folic acid intake, dietary intake of iodine, avoiding environmental pollution, avoiding rubella virus, avoiding the use of teratogenic drugs, genetic defects, avoiding consanguineous marriage, the best eugenic age, pets feeding before and during pregnancy, prenatal diagnosis, avoid smoking and secondhand smoke, the significance of alpha-fetoprotein test and pregnancy tome after taking contraceptive drugs were significantly higher than those of rural pregnant women with the education of at most college (P<0.05). Conclusion Cognition degree of birth defect prevention has certain educational and geographic difference and it is also related to special geographic environment of Urumqi. Prevent birth defects has a certain degree of education and regional differences, and also with the county special geographical environment.%目的:总结新疆维吾尔自治区乌鲁木齐市2006年1月~2013年7月调查维吾尔族聚居区生长地域和文化程度与出生缺陷预防认知度之间的关系。方法总结新疆维吾尔自治区乌鲁木齐市2006年1月~2013年7月322例出生缺陷儿数据,并将其与孕妇地域和文化程度进行结合分析,统计地域和文化程度与出生缺陷预防认知度之间的关系。结果大学专科及以上文化及城镇孕

  4. Birth Weight and Attention-Deficit/Hyperactivity Symptoms in Childhood and Early Adolescence: A Prospective Swedish Twin Study

    Science.gov (United States)

    Hultman, Christina M.; Torrang, Anna; Tuvblad, Catherine; Cnattingius, Sven; Larsson, Jan-Olov; Lichtenstein, Paul

    2007-01-01

    Objective: To determine whether low birth weight increases the risk of attention-deficit/hyperactivity disorder (ADHD) in childhood and early adolescence. Method: In a population-based sample of 1,480 twin pairs born in the period 1985-1986 ascertained from the Swedish Twin Registry, birth weight was collected prospectively through the Medical…

  5. Birth characteristics and Wilms tumors in children in the Nordic countries

    DEFF Research Database (Denmark)

    Schüz, Joachim; Schmidt, Lisbeth Samsø; Kogner, Per;

    2011-01-01

    Little is known about causes of Wilms tumor. Because of the young age at diagnosis, several studies have looked at various birth characteristics. We conducted a registry-based case-control study involving 690 cases of Wilms tumor aged 0-14 years, occurring in Denmark, Finland, Norway or Sweden...... during 1985-2006, individually matched to five controls drawn randomly from the Nordic childhood population. Information on birth characteristics was obtained from the population-based medical birth registries. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic......-for-gestational age girls also had a higher risk (2.48, 1.51-4.05), whereas no effect was seen for boys (1.12, 0.60-2.07). An association was seen with Apgar score at 5 min registry...

  6. An epidemiological study about air pollution exposure and the perinatal birth defects in six sentinel hospitals of a certain city in China%大气污染暴露与某市6家哨点医院围生儿出生缺陷的流行病学研究

    Institute of Scientific and Technical Information of China (English)

    汤俊; 姚慈将; 张健; 操基玉

    2015-01-01

    目的:探讨和分析某市大气污染对新生儿出生缺陷的影响。方法收集某市6家哨点医院2012—2013年期间分娩的孕满18周到出生后7 d 内的所有围产儿资料,包括分娩日期、孕产妇孕周以及孕天数和围生儿的性别等资料。同时收集该市2011—2013年的大气污染物日监测资料,包括二氧化硫、二氧化氮、可吸入污染和污染指数等。采用 SPSS16.0软件进行一般性描述、卡方检验、方差分析、Spearman 秩相关等统计分析。结果2年出生缺陷总发生率为11.63‰;2012年的出生缺陷发生率为10.49‰,2013年为12.76‰,但2年之间差异无统计学意义(P >0.05);不同性别出生缺陷患儿的发生率差异有统计学意义(P <0.05),男婴出生缺陷发生率高于女婴。出生缺陷发生率与大气污染物的 Spearman 秩相关分析结果显示:在孕前1月组和孕前2月组,出生缺陷发生率与可吸入颗粒物(PM10)和污染指数呈正相关。结论该次调查的该市妊娠期妇女在妊娠前期2个月内,大气 PM10暴露浓度和污染指数暴露水平与出生缺陷的发生存在统计学关联。%Objective Objective To investigate and analyze the city air pollution effects on birth defects.Methods Data of perinatal fetus from 18 -week gestation to 7 days after the birth,including date of delivery,maternal gestational weeks,days of pregnancy and gender,were collected from six sentinel hospitals of a city during 2012—2013.The daily monitoring data of air pollutants from 2011 to 2013,including sulfur dioxide,nitrogen dioxide,inhaled pollution and pollution index,were collected at the same time.SPSS16.0 soft-ware was used for general description,chisquare test,analysis of variance and Spearman rank correlation.Results The total incidence of birth defects was 11.63 per thousand in 2 years.The incidence of birth defects was 10.49 per thousand in 2012,12.76 per thousand in 2013

  7. Increased risk of severe congenital heart defects in offspring exposed to selective serotonin-reuptake inhibitors in early pregnancy

    DEFF Research Database (Denmark)

    Knudsen, Tanja Majbrit; Hansen, Anne Vinkel; Garne, Ester;

    2014-01-01

    BACKGROUND: Previous studies suggest a possible association between maternal use of selective serotonin-reuptake inhibitors (SSRIs) during early pregnancy and congenital heart defects (CHD). The purpose of this study was to verify this association by using validated data from the Danish EUROCAT...... Register, and secondary, to investigate whether the risk differs between various socioeconomic groups. METHODS: We conducted a cohort study based on Danish administrative register data linked with the Danish EUROCAT Register, which includes all CHD diagnosed in live births, fetal deaths and in pregnancies...... terminated due to congenital anomalies. The study population consisted of all registered pregnancies (n = 72,280) in Funen, Denmark in the period 1995-2008. SSRI-use was assessed using The Danish National Prescription Registry, information on marital status, maternal educational level, income, and country...

  8. 妊娠合并症与妊娠期接触化学毒物对出生缺陷影响的系统评价%Effect of pregnancy complications and gestational exposure to toxic chemical on birth defect:a systematic ;evaluation

    Institute of Scientific and Technical Information of China (English)

    岳书华; 万素馨

    2016-01-01

    目的:探讨妊娠合并症与妊娠期接触化学毒物对出生缺陷的影响,为制定最佳预防控制决策,实行有效的干预措施提供科学依据。方法根据纳入与排除标准进行文献评价与筛选,11篇文献纳入此次Meta 分析,累计病例3248例,对照5722例。由异质性检验结果决定采用固定或随机效应模型,并对合并结果进行χ2检验,同时应用漏斗图综合评估纳入文献的发表性偏倚。结果妊娠合并症的单因素分析合并效应值及其95%CI 为1.074(0.926~1.222),表明妊娠合并症是导致出生缺陷的危险因素;妊娠期接触化学毒物的单因素和多因素分析合并效应值及其95%CI 分别为1.426(1.147~1.704)、1.421(1.174~1.668),提示妊娠期接触化学毒物也是导致出生缺陷的危险因素。结论妊娠合并症和妊娠期接触化学毒物都是导致出生缺陷发生的危险因素,这为针对性预防出生缺陷的发生提供了参考。%Objective To investigate the impact of pregnancy complications and gestational exposure to toxic chemical on birth defect,to provide scientific basis for effective intervention measures.Methods 11 studies were included,the quality evaluation and information extraction were carried out on the studies according to include and exclude standard.3 248 examples in case group and 5 722 examples in control group.Fixed or random effects model was used according to heterogeneity test results,and the combined result was analyzed by Chi -square test.The publi-cation bias of the studies was also evaluated.Results The combined results of single factor analysis of pregnancy complications was 1.074(0.926 -1.222),showed that pregnancy complications were risk factors of birth defects.The combined results of single factor and multiple factors analysis of gestational exposure to toxic chemical were 1.426 (1.147 -1.704),1.421(1.174 -1.668),also showed that gestational

  9. Substance Identification Information from EPA's Substance Registry

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Substance Registry Services (SRS) is the authoritative resource for basic information about substances of interest to the U.S. EPA and its state and tribal...

  10. EPA Facility Registry Service (FRS): RBLC

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  11. Linking Medicare, Medicaid, and Cancer Registry Data...

    Data.gov (United States)

    U.S. Department of Health & Human Services — Linking Medicare, Medicaid, and Cancer Registry Data to Study the Burden of Cancers in West Virginia In the United States, the elderly carry an unequal burden of...

  12. Veterans Affairs Central Cancer Registry (VACCR)

    Data.gov (United States)

    Department of Veterans Affairs — The Veterans Affairs Central Cancer Registry (VACCR) receives and stores information on cancer diagnosis and treatment constraints compiled and sent in by the local...

  13. EPA Facility Registry Service (FRS): SDWIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  14. EPA Facility Registry Service (FRS): RMP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  15. EPA Facility Registry Service (FRS): TRI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  16. EPA Facility Registry Service (FRS): ACRES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of sites that link...

  17. EPA Facility Registry Service (FRS): BRAC

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  18. The United States Transuranium and Uranium Registries

    International Nuclear Information System (INIS)

    The United States Transuranium and Uranium Registries are unique parallel research programs devoted to the study of the actinide elements in man. The primary mission of the Registries is to verify and ensure the adequacy and applicability of radiation protection standards for the actinides. To accomplish this task, the Registries utilize tissues obtained postmortem from informed volunteer donors with confirmed or high likelihood of exposure to plutonium, americium, or other actinides. These are collected at autopsy and radiochemically analyzed for actinide content. The results, along with relevant details of occupational and exposure history, medical history and health physics data are used to determine the distribution, biokinetics and dosimetry of the actinides in humans, and to correlate estimates of deposition and dose made during life with postmortem findings. Other important applications of the Registries' research is scaling of animal studies to man and validation or refinement of biokinetic models on which the safety standards are based

  19. EPA Facility Registry Service (FRS): OIL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Oil...

  20. EPA Facility Registry Service (FRS): RADINFO

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  1. EPA Facility Registry Service (FRS): NCDB

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  2. EPA Facility Registry Service (FRS): RCRA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of hazardous waste...

  3. EPA Facility Registry Service (FRS): LANDFILL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of non-hazardous waste...

  4. EPA Facility Registry Service (FRS): CAMDBS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  5. EPA Facility Registry System (FRS): NCES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  6. The Italian registry of soft tissue tumors.

    Science.gov (United States)

    Clemente, C; Orazi, A; Rilke, F

    1988-01-01

    After a review of the incidence data on malignant soft-tissue tumors in Italy (Registro dei Tumori della Regione Lombardia, provincia di Varese), Europe (nine European Cancer Registries considered representative of various geographical areas) and extra-European countries (data of ten World Cancer Registries), the aim and the organization of the Italian Malignant Soft-Tissue Tumor Registry are described. The collection system is based on dedicated forms prepared for the computerization of all data. From 1.1.1985 to 31.3.1987, 207 cases of malignant and potentially malignant soft-tissue tumors entered the Registry, with exclusion of those sarcomas arising in viscera. The distribution, categorized by histologic type, sex and site, and the preliminary results on relapses and metastases are reported.

  7. EPA Facility Registry Service (FRS): NEI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  8. EPA Facility Registry Service (FRS): BIA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  9. EPA Facility Registry System (FRS): NEPT

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  10. EPA Facility Registry Service (FRS): ICIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  11. Findings from the Peutz-Jeghers syndrome registry of uruguay.

    Directory of Open Access Journals (Sweden)

    Asadur Tchekmedyian

    Full Text Available BACKGROUND: Peutz-Jeghers syndrome (PJS is characterized by intestinal polyposis, mucocutaneous pigmentation and an increased cancer risk, usually caused by mutations of the STK11 gene. This study collected epidemiological, clinical and genetic data from all Uruguayan PJS patients. METHODS: Clinical data were obtained from public and private medical centers and updated annually. Sequencing of the STK11 gene in one member of each family was performed. RESULTS AND DISCUSSION: 25 cases in 11 unrelated families were registered (15 males, 10 females. The average age of diagnosis and death was 18 and 41 years respectively. All patients had characteristic PJS pigmentation and gastrointestinal polyps. 72% required urgent surgery due to intestinal obstruction. 3 families had multiple cases of seizure disorder, representing 20% of cases. 28% developed cancer and two patients had more than one cancer. An STK11 mutation was found in 8 of the 9 families analyzed. A unique M136K missense mutation was noted in one family. Comparing annual live births and PJS birth records from 1970 to 2009 yielded an incidence of 1 in 155,000. CONCLUSION: The Uruguayan Registry for Peutz-Jeghers patients showed a high chance of emergent surgery, epilepsy, cancer and shortened life expectancy. The M136K missense mutation is a newly reported STK 11 mutation.

  12. Findings from the Peutz-Jeghers syndrome registry of Uruguay

    KAUST Repository

    Tchekmedyian, Asadur

    2013-11-19

    Background: Peutz-Jeghers syndrome (PJS) is characterized by intestinal polyposis, mucocutaneous pigmentation and an increased cancer risk, usually caused by mutations of the STK11 gene. This study collected epidemiological, clinical and genetic data from all Uruguayan PJS patients. Methods: Clinical data were obtained from public and private medical centers and updated annually. Sequencing of the STK11 gene in one member of each family was performed. Results and discussion: 25 cases in 11 unrelated families were registered (15 males, 10 females). The average age of diagnosis and death was 18 and 41 years respectively. All patients had characteristic PJS pigmentation and gastrointestinal polyps. 72% required urgent surgery due to intestinal obstruction. 3 families had multiple cases of seizure disorder, representing 20% of cases. 28% developed cancer and two patients had more than one cancer. An STK11 mutation was found in 8 of the 9 families analyzed. A unique M136K missense mutation was noted in one family. Comparing annual live births and PJS birth records from 1970 to 2009 yielded an incidence of 1 in 155,000. Conclusion: The Uruguayan Registry for Peutz-Jeghers patients showed a high chance of emergent surgery, epilepsy, cancer and shortened life expectancy. The M136K missense mutation is a newly reported STK 11 mutation. © 2013 Tchekmedyian et al.

  13. PCCR: Pancreatic Cancer Collaborative Registry.

    Science.gov (United States)

    Sherman, Simon; Shats, Oleg; Ketcham, Marsha A; Anderson, Michelle A; Whitcomb, David C; Lynch, Henry T; Ghiorzo, Paola; Rubinstein, Wendy S; Sasson, Aaron R; Grizzle, William E; Haynatzki, Gleb; Feng, Jianmin; Sherman, Alexander; Kinarsky, Leo; Brand, Randall E

    2011-01-01

    The Pancreatic Cancer Collaborative Registry (PCCR) is a multi-institutional web-based system aimed to collect a variety of data on pancreatic cancer patients and high-risk subjects in a standard and efficient way. The PCCR was initiated by a group of experts in medical oncology, gastroenterology, genetics, pathology, epidemiology, nutrition, and computer science with the goal of facilitating rapid and uniform collection of critical information and biological samples to be used in developing diagnostic, prevention and treatment strategies against pancreatic cancer. The PCCR is a multi-tier web application that utilizes Java/JSP technology and has Oracle 10 g database as a back-end. The PCCR uses a "confederation model" that encourages participation of any interested center, irrespective of its size or location. The PCCR utilizes a standardized approach to data collection and reporting, and uses extensive validation procedures to prevent entering erroneous data. The PCCR controlled vocabulary is harmonized with the NCI Thesaurus (NCIt) or Systematized Nomenclature of Medicine-Clinical Terms (SNOMED-CT). The PCCR questionnaire has accommodated standards accepted in cancer research and healthcare. Currently, seven cancer centers in the USA, as well as one center in Italy are participating in the PCCR. At present, the PCCR database contains data on more than 2,700 subjects (PC patients and individuals at high risk of getting this disease). The PCCR has been certified by the NCI Center for Biomedical Informatics and Information Technology as a cancer Biomedical Informatics Grid (caBIG(®)) Bronze Compatible product. The PCCR provides a foundation for collaborative PC research. It has all the necessary prerequisites for subsequent evolution of the developed infrastructure from simply gathering PC-related data into a biomedical computing platform vital for successful PC studies, care and treatment. Studies utilizing data collected in the PCCR may engender new approaches

  14. 孕前保健对某地区出生缺陷及其他不良妊娠结局影响的观察%Effect of preconception care on birth defect and other adverse pregnancy outcomes in A certain area

    Institute of Scientific and Technical Information of China (English)

    温小鲜; 陈桂玲; 梁建文; 陈凤仪; 陶小君; 陈莲芬; 李建萍; 王耀强; 张伟强; 赖剑锋

    2014-01-01

    Objective To explore the effect of preconception care on birth defect and other adverse pregnancy outcomes in Fanyu District. Methods Select 1000 sample size for research, 500 people who used of preconception care as the observation group, and 500 people without preconception care as the control group. Eugenic knowledge and awareness, taking the case of folic acid, prenatal care and treatment, adverse pregnancy outcomes of two groups were compared. Results Aware of knowledge about eugenics, the rate of taking folic acid and the treatment of chronic diseases coverage of observation group were significantly higher than the control group(P < 0.05); At 4 weeks pregnancy diagnosis rate and birth defects in prenatal screening coverage were significantly higher than the control group(P < 0.05), and the main risk factor for early pregnancy exposure levels was significantly lower than the observation group(P < 0.05); Preterm birth and Expired pregnancy rates, the incidence of neonatal asphyxia, and the incidence of birth defects were significantly lower than the control group(P < 0.05), and the amount of postpartum bleeding was significantly lower than the control group(P<0.05), the difference is statistically significant. Conclusion Preconception care can reduce birth defects, and improve the pregnancy outcome, we should further promote the smooth development of preconception care work.%目的:探讨孕前保健对广州市番禺区出生缺陷及其他不良妊娠结局的影响。方法选择1000个样本量进行研究,将进行孕前保健的500例设为观察组,未进行孕前保健的500例设为对照组,比较两组观察对象优生知识知晓率、叶酸服用情况、产前检查与治疗及不良妊娠结局等指标。结果观察组优生知识知晓率、叶酸服用率、慢性病的治疗覆盖率均明显优于对照组(P<0.05);观察组孕4周内妊娠确诊率、出生缺陷产前筛查覆盖率明显高于对照组,妊娠早期主

  15. Planned hospital birth versus planned home birth

    DEFF Research Database (Denmark)

    Olsen, O.; Clausen, J.A.

    2012-01-01

    Observational studies of increasingly better quality and in different settings suggest that planned home birth in many places can be as safe as planned hospital birth and with less intervention and fewer complications. This is an update of a Cochrane review first published in 1998.......Observational studies of increasingly better quality and in different settings suggest that planned home birth in many places can be as safe as planned hospital birth and with less intervention and fewer complications. This is an update of a Cochrane review first published in 1998....

  16. Maternal and birth characteristics in relation to childhood leukaemia.

    Science.gov (United States)

    Podvin, Danise; Kuehn, Carrie M; Mueller, Beth A; Williams, Michelle

    2006-07-01

    Our objective was to investigate the association of childhood leukaemia with selected maternal and birth characteristics by conducting a population-based case-control study using linked cancer registry and birth certificate records for Washington State. We compared maternal and infant characteristics of 595 Washington-born residents neonatal jaundice (OR 1.5; 95% CI 1.1, 2.1), and Down's syndrome (OR 31.3; 95% CI 6.4, 153.4) were associated with an increased risk of leukaemia. Among women with 2+ pregnancies, having at least two prior early (knowledge of inherent and possibly prenatal influences on the occurrence of this disease. PMID:16879503

  17. The Egyptian clinical trials’ registry profile: Analysis of three trial registries (International Clinical Trials Registry Platform, Pan-African Clinical Trials Registry and clinicaltrials.gov

    Directory of Open Access Journals (Sweden)

    Ahmed A. Zeeneldin

    2016-01-01

    Full Text Available Registering clinical trials (CTs in public domains enhances transparency, increases trust in research, improves participation and safeguards against publication bias. This work was done to study the profile of clinical research in Egypt in three CT registries with different scopes: the WHO International CT Registry Platform (ICTRP, the continental Pan-African CT Registry (PACTR and the US clinicaltrials.gov (CTGR. In March 2014, ICTRP, PACTR and CTGR were searched for clinical studies conducted in Egypt. It was found that the number of studies conducted in Egypt (percentage was 686 (0.30% in ICTRP, 56 (11.3% in PACTR and 548 (0.34% in CTGR. Most studies were performed in universities and sponsored by university/organization, industry or individual researchers. Inclusion of adults from both genders predominated. The median number of participants per study in the three registries ranged between 63 and 155. The conditions researched differed among the three registries and study purpose was mostly treatment followed by prevention. Endpoints were mostly efficacy followed by safety. Observational:Interventional studies (i.e. clinical trials represented 15.5%:84.5% in ICTRP, 0%:100% in PACTR and 16.4%:83.6% in CTGR. Most interventions were drugs or procedures. Observational studies were mostly prospective and cohort studies. Most CTs were phase 3 and tested drugs or procedures. Parallel group assignment and random allocation predominated. Blinding was implemented in many of trials and was mostly double-blind. We conclude that CTs from Egypt in trial registries are apparently low and do not accurately reflect clinical research conducted in Egypt or its potential. Development of an Egyptian CT registry is eagerly needed. Registering all Egyptian CTs in public domains is highly recommended.

  18. Triptan safety during pregnancy: a Norwegian population registry study

    International Nuclear Information System (INIS)

    Knowledge on triptan safety during pregnancy remains limited to their class effect or studies on sumatriptan. Our aim was to evaluate the individual effect of four most frequently used triptans on several pregnancy outcomes. We used the Norwegian prescription database to access information on triptans redeemed by pregnant women living in Norway between 2004 and 2007. This database was linked to the Medical Birth Registry of Norway covering every institutional delivery in Norway and providing information on pregnancy, delivery, maternal and neonatal health. Estimates of associations with pregnancy outcomes were obtained by Generalised Estimation Equations analysis. Of the 181,125 women in our study, 1,465 (0.8 %) redeemed triptans during pregnancy, and 1,095 (0.6 %) redeemed triptans before pregnancy only (disease comparison group). The population comparison group comprised the remaining 178,565 women. Using this group as reference, we found no associations between triptan redemption during pregnancy and congenital malformations. Second trimester redemption was associated with postpartum haemorrhage (adjusted OR 1.57; 95 % CI 1.19–2.07). The disease comparison group had an increased risk of major congenital malformations (adjusted OR 1.48; 95 % CI 1.11–1.97), low birth weight (adjusted OR 1.39; 95 % CI 1.08–1.81), and preterm birth (adjusted OR 1.30; 95 % CI 1.06–1.60). The association of triptans with postpartum hemorrhage could be attributable to decreased platelet agreeability occurring in severe migraine. Likewise, the increased risk of major congenital malformations and other adverse pregnancy outcomes in the disease comparison group might be attributable to migraine severity

  19. Planned place of birth

    DEFF Research Database (Denmark)

    Overgaard, Charlotte; Coxon, Kirstie; Stewart, Mary

    Title Planned place of birth: issues of choice, access and equity. Outline In Northern European countries, giving birth is generally safe for healthy women with uncomplicated pregnancies, and their babies. However, place of birth can affect women’s outcomes and experiences of birth. Whilst tertiary...... in Denmark Coxon K et al: Planned place of birth in England: perceptions of accessing obstetric units, midwife led units and home birth amongst women and their partners. How these papers interrelate These papers draw upon recent research in maternity care, undertaken in Denmark and in England. In both...

  20. The National Mental Health Registry (NMHR).

    Science.gov (United States)

    Aziz, A A; Salina, A A; Abdul Kadir, A B; Badiah, Y; Cheah, Y C; Nor Hayati, A; Ruzanna, Z Z; Sharifah Suziah, S M; Chee, K Y

    2008-09-01

    The National Mental Health Registry (NMHR) collects information about patients with mental disorder in Malaysia. This information allows us to estimate the incidence of selected mental disorders, and to evaluate risk factors and treatment in the country. The National Mental Health Registry (NMHR) presented its first report in 2004, a year after its establishment. The report focused on schizophrenia as a pioneer project for the National Mental Health Registry. The development of the registry has progressed with data collected from government-based facilities, the academia and the private sector. The 2003-2005 report was recently published and distributed. Since then the registry has progressed to include suicides and other mental illnesses such as depression. The NMHR Report 2003-2005 provides detailed information about the profile of persons with Schizophrenia who presented for the first time to various psychiatry and mental health providers throughout Malaysia. More detailed description regarding pharmacotherapy is reported and few cross tabulations done in an effort to provide better understanding and more clinically meaningful reports.

  1. The National Mental Health Registry (NMHR).

    Science.gov (United States)

    Aziz, A A; Salina, A A; Abdul Kadir, A B; Badiah, Y; Cheah, Y C; Nor Hayati, A; Ruzanna, Z Z; Sharifah Suziah, S M; Chee, K Y

    2008-09-01

    The National Mental Health Registry (NMHR) collects information about patients with mental disorder in Malaysia. This information allows us to estimate the incidence of selected mental disorders, and to evaluate risk factors and treatment in the country. The National Mental Health Registry (NMHR) presented its first report in 2004, a year after its establishment. The report focused on schizophrenia as a pioneer project for the National Mental Health Registry. The development of the registry has progressed with data collected from government-based facilities, the academia and the private sector. The 2003-2005 report was recently published and distributed. Since then the registry has progressed to include suicides and other mental illnesses such as depression. The NMHR Report 2003-2005 provides detailed information about the profile of persons with Schizophrenia who presented for the first time to various psychiatry and mental health providers throughout Malaysia. More detailed description regarding pharmacotherapy is reported and few cross tabulations done in an effort to provide better understanding and more clinically meaningful reports. PMID:19227671

  2. Social aspects of low birth weight.

    Science.gov (United States)

    Dunn, H G

    1984-05-01

    well as maternal habits, the quality of nutrition and health care for mother and child, and other "culture factors." The following seem important facets of the management of low birth weight children: optimal obstetric and perinatal care; "bonding" by parents visiting the intensive care nursery and handling the infant; anticipatory guidance; regular pediatric follow-up for at-risk infants; infant stimulation; early correction of refractive errors, strabismus, other visual defects, hearing defects and orthopedic deformities; and developmental assessments and school readiness tests. PMID:6713335

  3. [The possibility of registering in the Spanish Civil Registry children born abroad from surrogate mothers].

    Science.gov (United States)

    De Barrón Arniches, Paloma

    2009-01-01

    In the Spanish Civil Registry it is now possible to register "natural" children of a homosexual marriage born overseas through surrogate pregnancy. And this is despite article 10.1 of the current Spanish law regarding assisted human reproduction techniques, which declares fully null and void contracts renouncing maternal relationship, and orders imperatively that in these cases, the relationship of children is determined by birth. This article analyses and formulates a criticism regarding the Resolution of the Office of Registries and Notaries, of February 18, 2009, insisting on some relevant issues such as legal security and greater interest of the minor, in the context of the analysis of the facts of the case and the arguments put forward in the resolution.

  4. Defect modelling

    International Nuclear Information System (INIS)

    Calculations, drawing principally on developments at AERE Harwell, of the relaxation about lattice defects are reviewed with emphasis on the techniques required for such calculations. The principles of defect modelling are outlined and various programs developed for defect simulations are discussed. Particular calculations for metals, ionic crystals and oxides, are considered. (UK)

  5. Systematic Review of Cerebral Palsy Registries/Surveillance Groups: Relationships between Registry Characteristics and Knowledge Dissemination

    Science.gov (United States)

    Hurley, Donna S; Sukal-Moulton, Theresa; Gaebler-Spira, Deborah; Krosschell, Kristin J; Pavone, Larissa; Mutlu, Akmer; Dewald, Julius PA; Msall, Michael E

    2016-01-01

    The aims of this study were to provide a comprehensive summary of the body of research disseminated by Cerebral Palsy (CP) registries and surveillance programs from January 2009 through May 2014 in order to describe the influence their results have on our overall understanding of CP. Secondly, registries/surveillance programs and the work they produced were evaluated and grouped using standardized definitions and classification systems. Method A systematic review search in PubMed, CINAH and Embase for original articles published from 1 January 2009 to 20 May 2014 originating from or supported by population based CP registries and surveillance programs or population based national registries including CP were included. Articles were grouped by 2009 World CP Registry Congress aim, registry/surveillance program classification, geographical region, and the International Classification of Function, Disability and Health (ICF) domain. Registry variables were assessed using the ICF-CY classification. Results Literature searches returned 177 articles meeting inclusion criteria. The majority (69%) of registry/surveillance program productivity was related to contributions as a Resource for CP Research. Prevention (23%) and Surveillance (22%) articles were other areas of achievement, but fewer articles were published in the areas of Planning (17%) and Raising the Profile of CP (2%). There was a range of registry/surveillance program classifications contributing to this productivity, and representation from multiple areas of the globe, although most of the articles originated in Europe, Australia, and Canada. The domains of the ICF that were primarily covered included body structures and function at the early stages of life. Encouragingly, a variety of CP registry/surveillance program initiatives included additional ICF domains of participation and environmental and personal factors. Interpretation CP registries and surveillance programs, including novel non-traditional ones

  6. Congenital Anomalies Associated with Trisomy 18 or Trisomy 13 : A Registry-Based Study in 16 European Countries, 2000-2011

    NARCIS (Netherlands)

    Springett, Anna; Wellesley, Diana; Greenlees, Ruth; Loane, Maria; Addor, Marie-Claude; Arriola, Larraitz; Bergman, Jorieke; Cavero-Carbonell, Clara; Csaky-Szunyogh, Melinda; Draper, Elizabeth S.; Garne, Ester; Gatt, Miriam; Haeusler, Martin; Khoshnood, Babak; Klungsoyr, Kari; Lynch, Catherine; Dias, Carlos Matias; McDonnell, Robert; Nelen, Vera; O'Mahony, Mary; Pierini, Anna; Queisser-Luft, Annette; Rankin, Judith; Rissmann, Anke; Rounding, Catherine; Stoianova, Sylvia; Tuckerz, David; Zymak-Zakutnia, Natalya; Morris, Joan K.

    2015-01-01

    The aim of this study was to examine the prevalence of trisomies 18 and 13 in Europe and the prevalence of associated anomalies. Twenty-five population-based registries in 16 European countries provided data from 2000-2011. Cases included live births, fetal deaths (20+ weeks' gestation), and termina

  7. Birth Control Explorer

    Science.gov (United States)

    ... Relationships STIs Media Facebook Twitter Tumblr Shares · 5 Birth Control Explorer Sort by all methods most effective methods ... 100% effective method of birth control. LEARN MORE IUD An IUD is a T-shaped device that ...

  8. 重庆市1002例出生缺陷病残儿父母再生育情况调查%Investigation on the second reproduction status of 1002 pairs of parents who had infants with birth defects in Chongqing

    Institute of Scientific and Technical Information of China (English)

    李川海; 何杨; 马明福; 李安奇; 李杰; 杨皓; 付新云; 李家菊; 崔容; 刘浚

    2011-01-01

    Objective: To understand the second reproduction status of the parents who had infants with birth defects in Chongqing.Methods: The parents who had infants with birth defects and accorded with the criterion of second reproduction from 2003 to 2008 were surveyed by questionnaires, the questionnaires were filled by investigators.Results: Among 1 002 pairs of parents who had infants with birth defects, 982 pairs of parents received second reproduction direction, and 93.31% of them received preconception counseling; 809 pairs of parents gave birth to the second children, and 9 children were sick; 81.04% of the parents who had given the second children received prenatal examination, the main place of prenatal examination were medical institutes at county level (53.69%), followed by health clinics in towns and townships (31.50%) and medical institutes at city level ( 14.78% ); 93.15% of the pregnant women chose hospital delivery, and 6.80% of them gave birth to their infants in their home; 92.31% of the families had monitoring records established by family planning office.Conclusion: The second reproduction direction, preconception counseling and prenatal examination are not reasonable and standard, the follow - up and monitoring of bearing and rearing better children are not covered fully; scientific, reasonable and standard management services system of second reproduction and eugenic technology should be established quickly.%目的:了解重庆市出生缺陷病残儿父母再生育情况.方法:对2003~2008年经重庆市病残儿童医学鉴定,符合再生育的出生缺陷病残儿父母进行问卷调查,由调查员填写调查表.结果:1 002例出生缺陷病残儿童父母中,982例父母得到再生育指导,有93.31%进行了孕前咨询;有809例生育二胎,其中有9胎患病;有81.04%已生育二胎家庭进行了产前检查,产前检查地点主要在县级医疗机构(53.69%),其次为乡镇卫生院(31.50%),市级医疗机构(14

  9. The Danish Neuro-Oncology Registry

    DEFF Research Database (Denmark)

    Hansen, Steinbjørn; Nielsen, Jan; Laursen, René J;

    2016-01-01

    BACKGROUND: The Danish Neuro-Oncology Registry (DNOR) is a nationwide clinical cancer database that has prospectively registered data on patients with gliomas since January 2009. The purpose of this study was to describe the establishment of the DNOR and further to evaluate the database completen......BACKGROUND: The Danish Neuro-Oncology Registry (DNOR) is a nationwide clinical cancer database that has prospectively registered data on patients with gliomas since January 2009. The purpose of this study was to describe the establishment of the DNOR and further to evaluate the database...

  10. Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed.

    Science.gov (United States)

    Conlin, Ava Marie S; Bukowinski, Anna T; Gumbs, Gia R

    2015-08-26

    The National Smallpox Vaccine in Pregnancy Registry (NSVIPR) actively follows women inadvertently vaccinated with smallpox vaccine during or shortly before pregnancy to evaluate their reproductive health outcomes. Approximately 65% of NSVIPR participants also inadvertently received Anthrax Vaccine Adsorbed (AVA) while pregnant, providing a ready opportunity to evaluate pregnancy and infant health outcomes among these women. AVA-exposed pregnancies were ascertained using NSVIPR and electronic healthcare data. Rates of pregnancy loss and infant health outcomes, including major birth defects, were compared between AVA-exposed and AVA-unexposed pregnancies. Analyses included AVA-exposed and AVA-unexposed pregnant women who also received smallpox vaccine 28 days prior to or during pregnancy. Rates of adverse outcomes among the AVA-exposed group were similar to or lower than expected when compared with published reference rates and the AVA-unexposed population. The findings provide reassurance of the safety of AVA when inadvertently received by a relatively young and healthy population during pregnancy. PMID:26049005

  11. 海口市孕产妇预防出生缺陷知识、态度、行为及服务利用现况调查%Prevalence survey on knowledge, attitude, behavior, and service utilization of birth defects prevention among the pregnant women in Haikou

    Institute of Scientific and Technical Information of China (English)

    于英; 陈冰; 王波; 陈永莲

    2015-01-01

    Objective:To study knowledge,attitude,behavior,and service utilization of birth defects prevention among the pregnant women in Haikou,provide scientific reference for constructing appropriate regional prevention mode of birth defects.Methods:Stratified multi-stage cluster random sampling method was used to conduct a questionnaire survey among 2 996 pregnant women from December 2013 to December 2014 in Haikou city.Results:Most of the pregnant women took a positive attitude on birth defects,67.69% of the pregnant women took folic acid before pregnancy and during the first trimester of pregnancy; 52.20% of the pregnant women received premarital examination,the main reason for not receiving premarital medical examination was not necessary to check; 45.49% of the pregnant women received examination before pregnancy,the main reason for not receiving examination before pregnancy was an unplanned pregnancy; 30.11% of the pregnant women received eugenic knowledge related training,23.80% of the pregnant women received genetic counseling; 99.60% of the pregnant women received prenatal examination and 36.82% of the pregnant women received prenatal examination for the first time on the eighth gestational week and before the eighth gestational week ; the majority of pregnant women received prenatal examination for the first time over the sensitive period of fetal malformations.Conclusion:The health resources are concentrated in urban areas,the rural women have relatively few opportunities for maternal counseling and pre-pregnancy examination; to expand health service areas of the health department,the allocation of resources and capacity building should be strengthened,the consciousness and behavior of prevention of birth defects should be improved,the utilization of health services about birth defects prevention should be improved,which is a key point of prevention work for birth defects in Haikou.%目的:研究海口市孕产妇预防出生缺陷知识、态度

  12. The Creation Of The National Registry Of Rare Diseases In The Slovak Republic

    Directory of Open Access Journals (Sweden)

    Cisárik F.

    2014-08-01

    Its creation builds on the existing registries as well as on the structure of health care in the Slovak Republic. With the protection of personal data in mind, the collection of data will be carried out by the National Centre of Health Information (NCHI, which will also use the existing tool in the process of creation. Thanks to the cooperation between NCHI and the Slovak Society of Medical Genetics, NCHI developed separate reporting forms on rare diseases according to OMIM (Online Mendelian Inheritance in Man and ORPHANET rare disease coding (ORPHA codes of rare diseases, and the International classification of diseases code (ICD 10. The activities also include cooperation with the existing registries (part of which are rare diseases. For example National Registry of Congenital Developmental Heart Defects, national register of neuromuscular disorders, oncologic register or register of diabetes mellitus. Gathering the information from these registries we will extend the data about rare diseases in the Slovak republic. At the international level the participation in the European Surveillance of Congenital Anomalies (EUROCAT is important.

  13. Saving lives at birth

    DEFF Research Database (Denmark)

    Daysal, N. Meltem; Trandafir, Mircea; van Ewijk, Reyn

    2015-01-01

    Many developed countries have recently experienced sharp increases in home birth rates. This paper investigates the impact of home births on the health of low-risk newborns using data from the Netherlands, the only developed country where home births are widespread. To account for endogeneity...... in location of birth, we exploit the exogenous variation in distance from a mother’s residence to the closest hospital. We find that giving birth in a hospital leads to substantial reductions in newborn mortality. We provide suggestive evidence that proximity to medical technologies may be an important...

  14. Novel features of 3q29 deletion syndrome: Results from the 3q29 registry

    OpenAIRE

    Glassford, Megan R.; Jill A. Rosenfeld; Freedman, Alexa A.; Michael E Zwick; ,; Mulle, Jennifer G.

    2016-01-01

    3q29 deletion syndrome is caused by a recurrent, typically de novo heterozygous 1.6 Mb deletion, but because incidence of the deletion is rare (1 in 30,000 births) the phenotype is not well described. To characterize the range of phenotypic manifestations associated with 3q29 deletion syndrome, we have developed an online registry (3q29deletion.org) for ascertainment of study subjects and phenotypic data collection via Internet‐based survey instruments. We report here on data collected during...

  15. The Savant Syndrome Registry: A Preliminary Report.

    Science.gov (United States)

    Treffert, Darold A; Rebedew, David L

    2015-08-01

    A registry has been established to document certain characteristics on a sizeable worldwide sample of individuals with savant syndrome, a rare but remarkable condition in which persons with developmental disabilities, brain injury, or brain disease have some spectacular "islands" of skill or ability that stand in jarring, marked contrast to overall handicap. Of the 319 savants included in the registry, 90% are congenital savants, while 10% are acquired savants. The registry includes individuals from 33 countries, with 70% from the United States or Canada. Sex distribution was 79% male vs. 21% female (4:1). This report summarizes the findings in the congenital savant syndrome category of the registry. Among the individuals with congenital savant syndrome, the most common underlying disability was Autistic Spectrum Disorder (75%); various other central nervous system (CNS) disorders were present in the other 25%. Fifty-five percent possessed a single special skill, while 45% had multiple skills. Music was the most frequent principal skill followed by art, memory, mathematics, calendar calculating, language, visual-spatial/mechanical, athletic, computer, extrasensory perception, and other skills. PMID:26436185

  16. International Clinical Trials Registry Platform (ICTRP)

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ Introduction The mission of the WHO Intemational Clinical Trials Registry Platform is to ensure that a complete view of research is accessible to all those involved in health care decision making.This will improve research transparency and will ultimately strengthen tha validity and value of the scientific evidence base.The registration of all interventional trials is a scientific, ethical and moral responsibility.

  17. An active registry for bioinformatics web services.

    NARCIS (Netherlands)

    Pettifer, S.; Thorne, D.; McDermott, P.; Attwood, T.; Baran, J.; Bryne, J.C.; Hupponen, T.; Mowbray, D.; Vriend, G.

    2009-01-01

    SUMMARY: The EMBRACE Registry is a web portal that collects and monitors web services according to test scripts provided by the their administrators. Users are able to search for, rank and annotate services, enabling them to select the most appropriate working service for inclusion in their bioinfor

  18. Targeted development of registries of biological parts.

    Directory of Open Access Journals (Sweden)

    Jean Peccoud

    Full Text Available BACKGROUND: The design and construction of novel biological systems by combining basic building blocks represents a dominant paradigm in synthetic biology. Creating and maintaining a database of these building blocks is a way to streamline the fabrication of complex constructs. The Registry of Standard Biological Parts (Registry is the most advanced implementation of this idea. METHODS/PRINCIPAL FINDINGS: By analyzing inclusion relationships between the sequences of the Registry entries, we build a network that can be related to the Registry abstraction hierarchy. The distribution of entry reuse and complexity was extracted from this network. The collection of clones associated with the database entries was also analyzed. The plasmid inserts were amplified and sequenced. The sequences of 162 inserts could be confirmed experimentally but unexpected discrepancies have also been identified. CONCLUSIONS/SIGNIFICANCE: Organizational guidelines are proposed to help design and manage this new type of scientific resources. In particular, it appears necessary to compare the cost of ensuring the integrity of database entries and associated biological samples with their value to the users. The initial strategy that permits including any combination of parts irrespective of its potential value leads to an exponential and economically unsustainable growth that may be detrimental to the quality and long-term value of the resource to its users.

  19. The Savant Syndrome Registry: A Preliminary Report.

    Science.gov (United States)

    Treffert, Darold A; Rebedew, David L

    2015-08-01

    A registry has been established to document certain characteristics on a sizeable worldwide sample of individuals with savant syndrome, a rare but remarkable condition in which persons with developmental disabilities, brain injury, or brain disease have some spectacular "islands" of skill or ability that stand in jarring, marked contrast to overall handicap. Of the 319 savants included in the registry, 90% are congenital savants, while 10% are acquired savants. The registry includes individuals from 33 countries, with 70% from the United States or Canada. Sex distribution was 79% male vs. 21% female (4:1). This report summarizes the findings in the congenital savant syndrome category of the registry. Among the individuals with congenital savant syndrome, the most common underlying disability was Autistic Spectrum Disorder (75%); various other central nervous system (CNS) disorders were present in the other 25%. Fifty-five percent possessed a single special skill, while 45% had multiple skills. Music was the most frequent principal skill followed by art, memory, mathematics, calendar calculating, language, visual-spatial/mechanical, athletic, computer, extrasensory perception, and other skills.

  20. Correlating Orphaned Windows Registry Data Structures

    Directory of Open Access Journals (Sweden)

    Damir Kahved

    2009-06-01

    Full Text Available Recently, it has been shown that deleted entries of the Microsoft Windows registry (keys may still reside in the system files once the entries have been deleted from the active database. Investigating the complete keys in context may be extremely important from both a Forensic Investigation point of view and a legal point of view where a lack of context can bring doubt to an argument. In this paper we formalise the registry behaviour and show how a retrieved value may not maintain a relation to the part of the registry it belonged to and hence lose that context. We define registry orphans and elaborate on how they can be created inadvertently during software uninstallation and other system processes. We analyse the orphans and attempt to reconstruct them automatically. We adopt a data mining approach and introduce a set of attributes that can be applied by the forensic investigator to match values to their parents. The heuristics are encoded in a Decision Tree that can discriminate between keys and select those which most likely owned a particular orphan value.

  1. Registries in systemic sclerosis: a worldwide experience.

    Science.gov (United States)

    Galluccio, Felice; Walker, Ulrich A; Nihtyanova, Svetlana; Moinzadeh, Pia; Hunzelmann, Nicholas; Krieg, Thomas; Steen, Virginia; Baron, Murray; Sampaio-Barros, Percival; Kayser, Cristiane; Nash, Peter; Denton, Chris P; Tyndall, Alan; Müller-Ladner, Ulf; Matucci-Cerinic, Marco

    2011-01-01

    SSc is a multisystem disease characterized by an unpredictable course, high mortality and resistance to therapy. The complexity and severity of SSc is a growing burden on the health-care systems. As a result, researchers are seeking new therapeutic strategies for effectively managing these patients. Disease registries are used to support care management efforts for groups of patients with chronic diseases and are meaningful to capture and track key patient information to assist the physicians in managing patients. For these reasons, SSc surveys, research associations and consortiums are pivotal to conduct ongoing research and data collection to enhance disease knowledge and support research projects. Currently, there are several national SSc registries in the UK, Germany, USA, Canada, Brazil and Australia. There is also an international registry established by the European League Against Rheumatism scleroderma trial and research (EUSTAR) called minimal essential data set (MEDS) Online, which collects data from over 8000 patients from 92 centres worldwide, including 21 European centres and 9 centres outside Europe. By collecting, analysing and disseminating data on disease progression and patient responses to long-term disease management strategies, registries help to improve understanding of the disease and keep medical professionals up to date on the latest advances. PMID:21148153

  2. Validation of the Netherlands pacemaker patient registry

    NARCIS (Netherlands)

    Dijk, WA; Kingma, T; Hooijschuur, CAM; Dassen, WRM; Hoorntje, JCA; van Gelder, LM

    1997-01-01

    This paper deals with the validation of the information stored in the Netherlands central pacemaker patient database. At this moment the registry database contains information on more than 70500 patients, 85000 pacemakers and 90000 leads. The validation procedures consisted of an internal consistenc

  3. 20 CFR 655.144 - Electronic job registry.

    Science.gov (United States)

    2010-04-01

    ... order posted on the Electronic Job Registry until the end of 50 percent of the contract period as set... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Electronic job registry. 655.144 Section 655... Certification § 655.144 Electronic job registry. (a) Location of and placement in the electronic job...

  4. 37 CFR 201.25 - Visual Arts Registry.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Visual Arts Registry. 201.25... AND PROCEDURES GENERAL PROVISIONS § 201.25 Visual Arts Registry. (a) General. This section prescribes the procedures relating to the submission of Visual Arts Registry Statements by visual artists...

  5. Cancer risk among patients with congenital heart defects

    DEFF Research Database (Denmark)

    Olsen, Morten; Garne, Ester; Sværke, Claus;

    2013-01-01

    OBJECTIVE: We aimed to assess cancer risk in congenital heart defect patients, with and without Down's syndrome, compared with the general population. METHODS: We identified all patients born and diagnosed with congenital heart defects from 1977 to 2008 using the Danish National Registry of...... Patients, covering all Danish hospitals. We compared cancer incidence in the congenital heart defect cohort with that expected in the general population (∼5.5 million) using the Danish Cancer Registry, and computed age- and gender-standardised incidence ratios. RESULTS: We identified 15,905 congenital...... heart defect patients, contributing a total of 151,172 person-years at risk; the maximum length of follow-up was 31 years (median 8 years). In all, 53 patients were diagnosed with cancer, including 30 female and 23 male patients (standardised incidence ratio = 1.63; 95% confidence interval: 1...

  6. Towards a national trauma registry for the United Arab Emirates

    Directory of Open Access Journals (Sweden)

    Barka Ezedin

    2010-07-01

    Full Text Available Abstract Background Trauma is a major health problem in the United Arab Emirates (UAE as well as worldwide. Trauma registries provide large longitudinal databases for analysis and policy improvement. We aim in this paper to report on the development and evolution of a national trauma registry using a staged approach by developing a single-center registry, a two-center registry, and then a multi-center registry. The three registries were established by developing suitable data collection forms, databases, and interfaces to these databases. The first two registries collected data for a finite period of time and the third is underway. The steps taken to establish these registries depend on whether the registry is intended as a single-center or multi-center registry. Findings Several issues arose and were resolved during the development of these registries such as the relational design of the database, whether to use a standalone database management system or a web-based system, and the usability and security of the system. The inclusion of preventive medicine data elements is important in a trauma registry and the focus on road traffic collision data elements is essential in a country such as the UAE. The first two registries provided valuable data which has been analyzed and published. Conclusions The main factors leading to the successful establishment of a multi-center trauma registry are the development of a concise data entry form, development of a user-friendly secure web-based database system, the availability of a computer and Internet connection in each data collection center, funded data entry personnel well trained in extracting medical data from the medical record and entering it into the computer, and experienced personnel in trauma injuries and data analysis to continuously maintain and analyze the registry.

  7. Birth characteristics and Wilms tumors in children in the Nordic countries

    DEFF Research Database (Denmark)

    Schüz, Joachim; Schmidt, Lisbeth Samsø; Kogner, Per;

    2011-01-01

    during 1985-2006, individually matched to five controls drawn randomly from the Nordic childhood population. Information on birth characteristics was obtained from the population-based medical birth registries. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic......-based study, we confirmed earlier observations of an association between high birth weight and risk of Wilms tumor, but we found an effect only in girls. The higher risk of infants with low Apgar score might reflect hypoxia causing cell damage, adverse side effects of neonatal treatment or reverse causation...

  8. Family structure histories and high school completion: Evidence from a population based registry.

    Directory of Open Access Journals (Sweden)

    Lisa Strohschein

    2009-01-01

    Full Text Available This paper uses a life course approach to investigate the association between family structure histories and high school completion. Using data from a population-based data registry for the 1984 Manitoba birth cohort, we selected a sample of children born or adopted at birth into a married two-parent household (n = 9,403 and derived family structure histories for each child to the age of 18. Marital disruption occurred for 1,834 children (19.5%, with 337 children (3.6% of the total sample experiencing multiple changes in family structure. Logistic regression models showed that children who experienced marital dissolution before the age of 18 were significantly less likely to complete high school than children in intact households, and that children who were younger at the time of a first transition were more vulnerable than children who were older when their parents’ marriage ended. Further work is needed to

  9. 南宁市江南区孕妇出生缺陷预防知识态度行为调查%Investigation on attitude and behavior of pregnant women on birth defect prevention knowledge in Jiangnan District of Nanning City

    Institute of Scientific and Technical Information of China (English)

    曾江辉; 李建民; 梁秀云; 卢庆; 潘革; 梁少林; 杨兰

    2015-01-01

    目的:了解南宁市江南区孕妇对出生缺陷相关知识的知晓情况、获得途径和态度行为,为出生缺陷干预工作的服务方式和途径拓展思路。方法对2014年6~12月到该院产科初次建立围生期保健手册的孕妇进行问卷调查。结果共收回问卷1408份,其中有效问卷1362份,有效应答率96.73%。调查结果显示,孕妇对预防出生缺陷相关知识知晓率为2.94%~98.24%。除5项外(共计20项),其他项的知晓率均随着文化程度的增高而提高( P<0.05)。对预防出生缺陷相关知识获得途径主要是网络、手机(62.70%)和书刊、报纸(57.64%)。婚前医学检查率为96.77%,孕前医学检查率为33.26%,产前医学检查率为96.99%,计划妊娠率为61.82%。结论孕妇普遍知晓预防出生缺陷的基本知识,但不全面,大多数孕妇对优生有积极的态度和行为。依托网络和手机平台可扩大孕妇健康教育的广度和深度,提供更便捷、更有效的途径服务于大众。%Objective To understand the awareness situation ,acquiring route ,attitude and behaviors of birth defect related knowledge among the pregnant women in Jiangnan District of Nanning City in order to expand the thinking for the service mode and route of birth defect intervention work .Methods A questionnaire survey was per‐formed among the pregnant women with establishment of the perinatal health care manual in the obstetric department of the hospital from June to December 2014 .Results 1 408 questionnaires were recovered ,in which 1362 question‐naires were valid with the effective response rate of 96 .73% .The survey results indicated the awareness rate towards the birth defect prevention related knowledge ranged 2 .94% -96 .73% .Except for 5 items(sum to 20 items) ,the awareness rates of other items were increased with their education level (P<0 .05) .The acquiring routes of preven

  10. From institutionalized birth to home birth

    Directory of Open Access Journals (Sweden)

    Clara Fróes de Oliveira Sanfelice

    2014-06-01

    Full Text Available The study aimed to describe the experiences of a group of nurse-midwives from the city of Campinas, SP, Brasil, regarding the transition process from attending institutionalized births to attending home births, in the period 2011 – 2013. The study is of the experience report type; the reflections, perceptions and challenges experienced in this process were collected using the technique of brainstorming. Content analysis, as proposed by Bardin, was used, which yielded four thematic categories: a the hospital experience; b living with obstetric violence; c returning home and d the challenges of home care. It is concluded that attending home births offers greater satisfaction to the nurses, even in the face of various obstacles, as it is possible to offer a care to the woman and new-born which covers both the concept of comprehensiveness and the current scientific recommendations.

  11. Birth outcomes of women with celiac disease

    DEFF Research Database (Denmark)

    Nørgård, Bente; Fonager, Kirsten; Sørensen, Henrik Toft;

    1999-01-01

    OBJECTIVE: We aimed to examine birthweight, low birthweight (celiac disease in relation to their first hospitalization for the disease. METHODS: This was a historical cohort study based on The Danish Medical Birth Registry...... data of celiac women discharged from Danish hospitals from 1977-1992. The study included 211 newborns to 127 mothers with celiac disease, and 1260 control deliveries. RESULTS: Before celiac women were first hospitalized the mean birthweight of their newborns was 238 g (95% confidence interval [95% CI......] = 150, 325 g) lower than that of the control women, after adjustment for potential confounders. After the first hospitalization the mean birthweight for newborns of diseased women was higher than that of controls, by 67 g (95% CI = -88, 223 g) after adjustment for potential confounders. Before celiac...

  12. METADATA REGISTRY, ISO/IEC 11179

    Energy Technology Data Exchange (ETDEWEB)

    Pon, R K; Buttler, D J

    2008-01-03

    ISO/IEC-11179 is an international standard that documents the standardization and registration of metadata to make data understandable and shareable. This standardization and registration allows for easier locating, retrieving, and transmitting data from disparate databases. The standard defines the how metadata are conceptually modeled and how they are shared among parties, but does not define how data is physically represented as bits and bytes. The standard consists of six parts. Part 1 provides a high-level overview of the standard and defines the basic element of a metadata registry - a data element. Part 2 defines the procedures for registering classification schemes and classifying administered items in a metadata registry (MDR). Part 3 specifies the structure of an MDR. Part 4 specifies requirements and recommendations for constructing definitions for data and metadata. Part 5 defines how administered items are named and identified. Part 6 defines how administered items are registered and assigned an identifier.

  13. Forensic Analysis of the Windows 7 Registry

    Directory of Open Access Journals (Sweden)

    Khawla Abdulla Alghafli

    2010-12-01

    Full Text Available The recovery of digital evidence of crimes from storage media is an increasingly time consuming process as the capacity of the storage media is in a state of constant growth. It is also a difficult and complex task for the forensic investigator to analyse all of the locations in the storage media. These two factors, when combined, may result in a delay in bringing a case to court. The concept of this paper is to start the initial forensic analysis of the storage media in locations that are most likely to contain digital evidence, the Windows Registry. Consequently, the forensic analysis process and the recovery of digital evidence may take less time than would otherwise be required. In this paper, the Registry structure of Windows 7 is discussed together with several elements of information within the Registry of Windows 7 that may be valuable to a forensic investigator. These elements were categorized into five groups which are system, application, networks, attached devices and the history lists. We have discussed the values of identified elements to a forensic investigator. Also, a tool was implemented to perform the function of extracting these elements and presents them in usable form to a forensics investigator.

  14. Registry of Mineral and Petroleum Titles

    Energy Technology Data Exchange (ETDEWEB)

    Maclellan, I. M.; Kaizer, J. L.; McCulloch, P. D.; Ratcliffe, R.; Wenning, A. S. [Nova Scotia Dept. of Natural Resources, Halifax, NS (Canada)

    2000-07-01

    Activities of the Nova Scotia Registry of Mineral and Petroleum Titles are described, including statistical information about staking and mining activity in the province during 1999. In terms of activities, the Registry receives applications and issues licenses and leases for mineral and petroleum rights, receives statements of exploration expenditures and assessment reports that pertain to renewal of licenses and leases, maintains maps showing the disposition of lands under license or lease, and maintains a system of prospector registration. In addition, the Registry processes applications for underground gas storage rights and treasure trove rights and maintains a database of information concerning production and employment in Nova Scotia mines and quarries. At the end 1999 there were 230,660 hectares under exploration licence. Exploration expenditures, including engineering, economic and feasibility studies during 1999 totalled $4.2 million, mostly by junior mining companies searching for industrial mineral commodities. Mining activity during 1999 generated revenues of $340 million. Coal production dropped by 25 per cent, due mainly to the closure of the Phalen Mine. Gypsum production was up to 7.9 million tonnes; shipments of cement, barite and clay products also increased during 1999; salt production remained unchanged from 1998 with 842,000 tonnes. Production of construction aggregates totalled 10.6 million tonnes, down slightly from the year before. Mineral industry employment was roughly 2,500 persons, down by 24 per cent from 1998 levels, due primarily to the closure of the Phalen Mine.

  15. Birth Month Affects Longevity

    Science.gov (United States)

    Abel, Ernest L.; Kruger, Michael L.

    2010-01-01

    The authors examined the association between birth month and longevity for major league baseball players. Players born in the month of November had the greatest longevities whereas those born in June had the shortest life spans. These differences remained after controlling for covariates such as birth year, career length, age at debut, height, and…

  16. The defect

    CERN Document Server

    Kuhlmann, Franz-Viktor

    2010-01-01

    We give an introduction to the valuation theoretical phenomenon of "defect", also known as "ramification deficiency". We describe the role it plays in deep open problems in positive characteristic: local uniformization (the local form of resolution of singularities), the model theory of valued fields, the structure theory of valued function fields. We give several examples of algebraic extensions with non-trivial defect. We indicate why Artin-Schreier defect extensions play a central role and describe a way to classify them. Further, we give an overview of various results about the defect that help to tame or avoid it, in particular "stability" theorems and theorems on "henselian rationality", and show how they are applied. Finally, we include a list of open problems.

  17. Paravaginal defect

    DEFF Research Database (Denmark)

    Arenholt, Louise T S; Pedersen, Bodil Ginnerup; Glavind, Karin;

    2016-01-01

    , arcus tendineus fascia pelvis (ATFP), pubocervical fascia, and uterosacral/cardinal ligaments. Studies conclude that physical examination is inconsistent in detecting paravaginal defects. Ultrasound (US) and magnetic resonance imaging (MRI) have been used to describe patterns in the appearance...

  18. Narcissism and birth order.

    Science.gov (United States)

    Eyring, W E; Sobelman, S

    1996-04-01

    The purpose of this investigation was to clarify the relationship between birth-order position and the development of narcissism, while refining research and theory. The relationship between birth-order status and narcissism was examined with a sample of 79 undergraduate students (55 women and 24 men). These subjects were placed in one of the four following birth-order categories of firstborn, second-born, last-born, and only children. These categories were chosen given their significance in Adlerian theory. Each subject completed the Narcissistic Personality Inventory and a demographic inventory. Based on psychodynamic theory, it was hypothesized that firstborn children were expected to score highest, but statistical significance was not found for an association between narcissism and birth order. Further research is urged to investigate personality theory as it relates to parenting style and birth order.

  19. Choroidal thickness in relation to birth parameters in 11- to 12-year-old children

    DEFF Research Database (Denmark)

    Li, Xiao Q; Munkholm, Anja; Larsen, Michael;

    2015-01-01

    to -1] μm, P = 0.04) compared with appropriate for gestation children. Longer birth length was associated with a thicker subfoveal choroid (2 [1-4] μm/cm, P = 0.005). Macular choroidal thickness at 16 extrafoveal locations was measured in a subset of children and found to have the same associations......PURPOSE: To examine choroidal thickness in a population-based child cohort in relation to birth parameters. METHODS: The Copenhagen Child Cohort 2000 Eye Study examined 1406 children aged 11 to 12 years using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), ocular...... biometry and measurement of height, weight, refraction, and self-reported pubertal development status. Birth parameters were obtained from the Danish Medical Birth Registry. RESULTS: The subfoveal choroid in low birth weight children (

  20. Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the Dutch and Danish biliary atresia registries

    DEFF Research Database (Denmark)

    Hasselt, P.M. van; Koning, T.J. de; Vries, E. de;

    2008-01-01

    OBJECTIVE: Newborns routinely receive vitamin K to prevent vitamin K deficiency bleeding. The efficacy of oral vitamin K administration may be compromised in infants with unrecognized cholestasis. We aimed to compare the risk of vitamin K deficiency bleeding under different prophylactic regimens...... in infants with biliary atresia. PATIENTS AND METHODS: From Dutch and Danish national biliary atresia registries, we retrieved infants who were either breastfed and received 1 mg of oral vitamin K at birth followed by 25 microg of daily oral vitamin K prophylaxis (Netherlands, 1991-2003), 2 mg of oral...... vitamin K at birth followed by 1 mg of weekly oral prophylaxis (Denmark, 1994 to May 2000), or 2 mg of intramuscular prophylaxis at birth (Denmark, June 2000-2005) or were fed by formula. We determined the absolute and relative risk of severe vitamin K deficiency and vitamin K deficiency bleeding...

  1. Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997–2008

    Directory of Open Access Journals (Sweden)

    Lamminpää Reeta

    2012-06-01

    Full Text Available Abstract Background Preeclampsia is a frequent syndrome and its cause has been linked to multiple factors, making prevention of the syndrome a continuous challenge. One of the suggested risk factors for preeclampsia is advanced maternal age. In the Western countries, maternal age at first delivery has been steadily increasing, yet few studies have examined women of advanced maternal age with preeclampsia. The purpose of this registry-based study was to compare the obstetric outcomes in primiparous and preeclamptic women younger and older than 35 years. Methods The registry-based study used data from three Finnish health registries: Finnish Medical Birth Register, Finnish Hospital Discharge Register and Register of Congenital Malformations. The sample contained women under 35 years of age (N = 15,437 compared with those 35 and over (N = 2,387 who were diagnosed with preeclampsia and had their first singleton birth in Finland between 1997 and 2008. In multivariate modeling, the main outcome measures were Preterm delivery (before 34 and 37 weeks, low Apgar score (5 min., small-for-gestational-age, fetal death, asphyxia, Cesarean delivery, induction, blood transfusion and admission to a Neonatal Intensive Care Unit. Results Women of advanced maternal age (AMA exhibited more preeclampsia (9.4% than younger women (6.4%. They had more prior terminations (25 ( Conclusions Preeclampsia is more common in women with advanced maternal age. Advanced maternal age is an independent risk factor for adverse outcomes in first-time mothers with preeclampsia.

  2. Adolescent Births 2010-2012

    Data.gov (United States)

    U.S. Department of Health & Human Services — http://tinyurl.com/AdolescentBirthRatesMap, http://tinyurl.com/PercentOfRepeatBirthsMap, http://tinyurl.com/PercentOfBirthsInHighPoverty. This dataset contains...

  3. Registries as Tools for Clinical Excellence and the Development of the Pelvic Floor Disorders Registry.

    Science.gov (United States)

    Weber LeBrun, Emily E

    2016-03-01

    Surgical device innovation has been less regulated than drug development, allowing integration of unproven techniques and materials into standard practice. Successful device registries gather information on patient outcomes and can provide postmarket surveillance of new technologies and allow comparison with currently established treatments or devices. The Pelvic Floor Disorders Registry was developed in collaboration with the Food and Drug Administration, device manufacturers, and other stakeholders to serve as a platform for industry-sponsored postmarket device surveillance, investigator-initiated research, and quality and effectiveness benchmarking, all designed to improve the care of women with pelvic floor disorders. PMID:26880512

  4. Evolution of the Birth Plan

    OpenAIRE

    Kaufman, Tamara

    2007-01-01

    Many birth professionals are discarding the birth plan as an outdated and ineffectual document. This column discusses the past limitations and present uses of the birth plan in an effort to enhance current teaching on how expectant parents can write and use this important document. Encouraging expectant parents to prepare two separate, but corresponding, birth plans—the “Discussion Birth Plan” and the “Hospital Birth Plan”—is proposed. Teaching suggestions and possible implications are explor...

  5. [Influence of registries on the quality of care].

    Science.gov (United States)

    Stengel, D; Dreinhöfer, K; Kostuj, T

    2016-06-01

    Registries are a topic of lively debate amongst all stakeholders in healthcare, politics and economics. In general, registries are national or international (prospective) databases documenting the current state of diagnostic, therapeutic and long-term outcome variables of subjects with a distinct condition or health problem. The access to and handling of registry information is subject to strict legal, methodological and ethical principles and regulations before these data can be scientifically utilized and reentered into the routine daily practice. Because of the representativeness and reality of data, registries are widely regarded as the backbone of health systems and budgets.Currently there is only indirect evidence that registries influence outcomes and the quality of care. Recent statistical techniques may allow quasi-experimental modelling of observational information. In orthopedic and trauma surgery, current and upcoming registries should be wisely utilized to develop and evaluate innovations and to make informed decisions relevant to care. PMID:27164976

  6. Change in primary midwife-led care in the Netherlands in 2000-2008: A descriptive study of caesarean sections and other interventions among 807,437 low-risk births

    NARCIS (Netherlands)

    Offerhaus, P.M.; Jonge, A. de; Pal-de-Bruin, K.M. van der; Hukkelhoven, C.W.P.M.; Scheepers, P.L.; Lagro-Janssen, A.

    2015-01-01

    OBJECTIVE: to study whether an increase in intrapartum referrals in primary midwife-led care births in the Netherlands is accompanied by an increase in caesarean sections. DESIGN: nationwide descriptive study. SETTING: The Netherlands Perinatal Registry. PARTICIPANTS: 807,437 births of nine year coh

  7. Change in primary midwife-led care in the Netherlands in 2000-2008: A descriptive study of caesarean sections and other interventions among 807,437 low risk births

    NARCIS (Netherlands)

    Offerhaus, P.M.; Jonge, A. de; Pal-de Bruin, K.M. van der; Hukkelhoven, C.W.P.M.; Scheepers, P.L.H.; Lagro-Janssen, A.L.M.

    2015-01-01

    Objective: to study whether an increase in intrapartum referrals in primary midwife-led care births in the Netherlands is accompanied by an increase in caesarean sections. Design: nationwide descriptive study. Setting: The Netherlands Perinatal Registry. Participants: 807,437 births of nine year coh

  8. Change in primary midwife-led care in the Netherlands in 2000–2008: A descriptive study of caesarean sections and other interventions among 789,795 low risk births

    NARCIS (Netherlands)

    Offerhaus, P.M.; Jonge, A. de; Pal-de Bruin, K.M. van der; Hukkelhoven, C.W.P.M.; Scheepers, P.L.H.; Lgero-Jansen, A.L.M.

    2014-01-01

    OBJECTIVE: to study whether an increase in intrapartum referrals in primary midwife-led care births in the Netherlands is accompanied by an increase in caesarean sections. DESIGN: nationwide descriptive study. SETTING: the Netherlands Perinatal Registry. PARTICIPANTS: 789,795 births of nine year coh

  9. Change in primary midwife-led care in the Netherlands in 2000-2008: A descriptive study of caesarean sections and other interventions among 789,795 low risk births

    NARCIS (Netherlands)

    Offerhaus, P.M.; Jonge, A. de; Pal-de Bruin, K.M. van der; Hukkelhoven, C.W.P.M.; Scheepers, P.L.H.; Lagro-Janssen, A.L.M.

    2014-01-01

    Objective to study whether an increase in intrapartum referrals in primary midwife-led care births in the Netherlands is accompanied by an increase in caesarean sections. Design nationwide descriptive study. Setting the Netherlands Perinatal Registry. Participants 789,795 births of nine year cohorts

  10. Change in primary midwife-led care in the Netherlands in 2000-2008: a descriptive study of caesarean sections and other interventions among 789,795 low risk births

    NARCIS (Netherlands)

    Offerhaus, P.M.; Jonge, A. de; Pal-de Bruin, K.M. van der; Hukkelhoven, C.W.P.M.; Scheepers, P.L.; Lagro-Janssen, A.

    2014-01-01

    OBJECTIVE: to study whether an increase in intrapartum referrals in primary midwife-led care births in the Netherlands is accompanied by an increase in caesarean sections. DESIGN: nationwide descriptive study. SETTING: the Netherlands Perinatal Registry. PARTICIPANTS: 789,795 births of nine year coh

  11. Prostate Cancer Registries: Current Status and Future Directions

    OpenAIRE

    Gandaglia, G; Bray, F.; Cooperberg, MR; Karnes, RJ; Leveridge, MJ; Moretti, K; Murphy, DG; Penson, DF; Miller, DC

    2016-01-01

    © 2015 European Association of Urology. Context: Disease-specific registries that enroll a considerable number of patients play a major role in prostate cancer (PCa) research. Objective: To evaluate available registries, describe their strengths and limitations, and discuss the potential future role of PCa registries in outcomes research. Evidence acquisition: We performed a literature review of the Medline, Embase, and Web of Science databases. The search strategy included the terms prostate...

  12. The Danish Multiple Sclerosis Registry. History, data collection and validity

    DEFF Research Database (Denmark)

    Koch-Henriksen, N; Rasmussen, S; Stenager, E;

    2001-01-01

    The Danish Multiple Sclerosis Registry was formally established in 1956 but started operating in 1949 with a nationwide prevalence survey. Since then, the Registry has continued collecting data on new and old cases of multiple sclerosis (MS) or suspected MS from multiple sources. The Registry...... instrument for monitoring incidence and prevalence, analysing survival, performing genetic analysis, providing unselected patient samples for clinical analyses, performing case-control studies and prospective studies and estimating the need for treatment and care....

  13. Australia and New Zealand Dialysis and Transplant Registry

    OpenAIRE

    McDonald, Stephen P

    2015-01-01

    The ANZDATA Registry includes all patients treated with renal replacement therapy (RRT) throughout Australia and New Zealand. Funding is predominantly from government sources, together with the non-government organization Kidney Health Australia. Registry operations are overseen by an Executive committee, and a Steering Committee with wide representation. Data is collected from renal units throughout Australia and New Zealand on a regular basis, and forwarded to the Registry. Areas covered in...

  14. Prenatal diagnosis of fetal aortopulmonary septal defect with ventricular septal defect by two-dimension echocardiography

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Fetal aortopulmonary septal defect (APSD) is an extremely rare condition, accounting for 0.1%-0.2% of all cardiac defects in live births world wide.1 Hospital mortality is 13% and 33% for simple and complex APSD, respectively.2 This rare cardiac defect refers to a congenital malformation in the development of the arteriosus truncus septum, and is usually associated with a wide variety of other structural cardiac anomalies such as ventricular septal defect (VSD), pulmonary valve stegnosis and so on.3 Prenatal diagnosis of an APSD is possible by echocardiography.

  15. Cancer, infant mortality and birth sex-ratio in Fallujah, Iraq 2005-2009.

    Science.gov (United States)

    Busby, Chris; Hamdan, Malak; Ariabi, Entesar

    2010-07-01

    There have been anecdotal reports of increases in birth defects and cancer in Fallujah, Iraq blamed on the use of novel weapons (possibly including depleted uranium) in heavy fighting which occurred in that town between US led forces and local elements in 2004. In Jan/Feb 2010 the authors organised a team of researchers who visited 711 houses in Fallujah, Iraq and obtained responses to a questionnaire in Arabic on cancer, birth defects and infant mortality. The total population in the resulting sample was 4,843 persons with and overall response rate was better than 60%. Relative Risks for cancer were age-standardised and compared to rates in the Middle East Cancer Registry (MECC, Garbiah Egypt) for 1999 and rates in Jordan 1996-2001. Between Jan 2005 and the survey end date there were 62 cases of cancer malignancy reported (RR = 4.22; CI: 2.8, 6.6; p < 0.00000001) including 16 cases of childhood cancer 0-14 (RR = 12.6; CI: 4.9, 32; p < 0.00000001). Highest risks were found in all-leukaemia in the age groups 0-34 (20 cases RR = 38.5; CI: 19.2, 77; p < 0.00000001), all lymphoma 0-34 (8 cases, RR = 9.24;CI: 4.12, 20.8; p < 0.00000001), female breast cancer 0-44 (12 cases RR = 9.7;CI: 3.6, 25.6; p < 0.00000001) and brain tumours all ages (4 cases, RR = 7.4;CI: 2.4, 23.1; P < 0.004). Infant mortality was based on the mean birth rate over the 4 year period 2006-2009 with 1/6th added for cases reported in January and February 2010. There were 34 deaths in the age group 0-1 in this period giving a rate of 80 deaths per 1,000 births. This may be compared with a rate of 19.8 in Egypt (RR = 4.2 p < 0.00001) 17 in Jordan in 2008 and 9.7 in Kuwait in 2008. The mean birth sex-ratio in the recent 5-year cohort was anomalous. Normally the sex ratio in human populations is a constant with 1,050 boys born to 1,000 girls. This is disturbed if there is a genetic damage stress. The ratio of boys to 1,000 girls in the 0-4, 5-9, 10-14 and 15-19 age cohorts in the Fallujah sample were 860

  16. Cancer, Infant Mortality and Birth Sex-Ratio in Fallujah, Iraq 2005–2009

    Science.gov (United States)

    Busby, Chris; Hamdan, Malak; Ariabi, Entesar

    2010-01-01

    There have been anecdotal reports of increases in birth defects and cancer in Fallujah, Iraq blamed on the use of novel weapons (possibly including depleted uranium) in heavy fighting which occurred in that town between US led forces and local elements in 2004. In Jan/Feb 2010 the authors organised a team of researchers who visited 711 houses in Fallujah, Iraq and obtained responses to a questionnaire in Arabic on cancer, birth defects and infant mortality. The total population in the resulting sample was 4,843 persons with and overall response rate was better than 60%. Relative Risks for cancer were age-standardised and compared to rates in the Middle East Cancer Registry (MECC, Garbiah Egypt) for 1999 and rates in Jordan 1996–2001. Between Jan 2005 and the survey end date there were 62 cases of cancer malignancy reported (RR = 4.22; CI: 2.8, 6.6; p < 0.00000001) including 16 cases of childhood cancer 0–14 (RR = 12.6; CI: 4.9, 32; p < 0.00000001). Highest risks were found in all-leukaemia in the age groups 0–34 (20 cases RR = 38.5; CI: 19.2, 77; p < 0.00000001), all lymphoma 0–34 (8 cases, RR = 9.24;CI: 4.12, 20.8; p < 0.00000001), female breast cancer 0–44 (12 cases RR = 9.7;CI: 3.6, 25.6; p < 0.00000001) and brain tumours all ages (4 cases, RR = 7.4;CI: 2.4, 23.1; P < 0.004). Infant mortality was based on the mean birth rate over the 4 year period 2006–2009 with 1/6th added for cases reported in January and February 2010. There were 34 deaths in the age group 0–1 in this period giving a rate of 80 deaths per 1,000 births. This may be compared with a rate of 19.8 in Egypt (RR = 4.2 p < 0.00001) 17 in Jordan in 2008 and 9.7 in Kuwait in 2008. The mean birth sex-ratio in the recent 5-year cohort was anomalous. Normally the sex ratio in human populations is a constant with 1,050 boys born to 1,000 girls. This is disturbed if there is a genetic damage stress. The ratio of boys to 1,000 girls in the 0–4, 5–9, 10–14 and 15–19 age cohorts in the

  17. Cancer, Infant Mortality and Birth Sex-Ratio in Fallujah, Iraq 2005–2009

    Directory of Open Access Journals (Sweden)

    Malak Hamdan

    2010-07-01

    Full Text Available There have been anecdotal reports of increases in birth defects and cancer in Fallujah, Iraq blamed on the use of novel weapons (possibly including depleted uranium in heavy fighting which occurred in that town between US led forces and local elements in 2004. In Jan/Feb 2010 the authors organised a team of researchers who visited 711 houses in Fallujah, Iraq and obtained responses to a questionnaire in Arabic on cancer, birth defects and infant mortality. The total population in the resulting sample was 4,843 persons with and overall response rate was better than 60%. Relative Risks for cancer were age-standardised and compared to rates in the Middle East Cancer Registry (MECC, Garbiah Egypt for 1999 and rates in Jordan 1996–2001. Between Jan 2005 and the survey end date there were 62 cases of cancer malignancy reported (RR = 4.22; CI: 2.8, 6.6; p < 0.00000001 including 16 cases of childhood cancer 0-14 (RR = 12.6; CI: 4.9, 32; p < 0.00000001. Highest risks were found in all-leukaemia in the age groups 0-34 (20 cases RR = 38.5; CI: 19.2, 77; p < 0.00000001, all lymphoma 0–34 (8 cases, RR = 9.24;CI: 4.12, 20.8; p < 0.00000001, female breast cancer 0–44 (12 cases RR = 9.7;CI: 3.6, 25.6; p < 0.00000001 and brain tumours all ages (4 cases, RR = 7.4;CI: 2.4, 23.1; P < 0.004. Infant mortality was based on the mean birth rate over the 4 year period 2006–2009 with 1/6th added for cases reported in January and February 2010. There were 34 deaths in the age group 0–1 in this period giving a rate of 80 deaths per 1,000 births. This may be compared with a rate of 19.8 in Egypt (RR = 4.2 p < 0.00001 17 in Jordan in 2008 and 9.7 in Kuwait in 2008. The mean birth sex-ratio in the recent 5-year cohort was anomalous. Normally the sex ratio in human populations is a constant with 1,050 boys born to 1,000 girls. This is disturbed if there is a genetic damage stress. The ratio of boys to 1,000 girls in the 0–4, 5–9, 10–14 and 15–19 age cohorts in

  18. The International Takotsubo Registry: Rationale, Design, Objectives, and First Results.

    Science.gov (United States)

    Ghadri, Jelena-R; Cammann, Victoria L; Templin, Christian

    2016-10-01

    Takotsubo syndrome (TTS) was first described in Japan in 1990. The clinical presentation is similar to that of acute coronary syndrome (ACS). Cardiac enzymes are commonly elevated. A global initiative was launched and the InterTAK Registry was established to provide a systematic database. The major goals of the International Takotsubo Registry (InterTAK Registry) are to provide a comprehensive clinical characterization on natural history, treatment, and outcomes. We linked a biorepository to identify biomarkers for the diagnosis and prognosis and to investigate the genetic basis as well as disease-related factors. We focus on the rationale, objectives, design, and first results of the InterTAK Registry. PMID:27638029

  19. Emmetropisation following preterm birth

    OpenAIRE

    Saunders, K J; McCulloch, D L; Shepherd, A.J.; Wilkinson, A. G.

    2002-01-01

    Background/aims: Even in the absence of retinopathy of prematurity (ROP), premature birth signals increased risk for abnormal refractive development. The present study examined the relation between clinical risk factors and refractive development among preterm infants without ROP.

  20. Accredited Birth Centers

    Science.gov (United States)

    ... 717-933-9743 Accredited since January 2016 100 Bright Eyes Midwifery and Wild Rivers Women's Health Accredited ... Birthing Center-Cedar Park Accredited 1130 Cottonwood Creek Trail Building D Suite 2 Cedar Park, TX 78613 ...

  1. Cesarean Section Birth

    Medline Plus

    Full Text Available ... experience the miracle of birth during a live Internet broadcast from Shawnee Mission Medical Center in Merriam, ... later if you prefer. Now let me turn things over to the obstetrician performing the delivery to ...

  2. Wealthy Flou Birth Control

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    China’s family planning policies have come under criticism for failing to con birth rates among wealthy families A ccording to the family planning policies, Hong Youfu, a restaurant owner in Fangcun District of

  3. Cesarean Section Birth

    Medline Plus

    Full Text Available ... you will experience the miracle of birth during a live Internet broadcast from Shawnee Mission Medical Center ... hour, operating surgeon Dr. Leah Ridgway will perform a caesarean section delivery while Dr. Reagan Wittek will ...

  4. Cesarean Section Birth

    Medline Plus

    Full Text Available ... after delivery. And that's over here so that mom can hear the baby and the baby will ... So we don't encourage elective first-time moms having a cesarean birth. 00:09:12 LEAH ...

  5. Thyroid Cancer and Tumor Collaborative Registry (TCCR).

    Science.gov (United States)

    Shats, Oleg; Goldner, Whitney; Feng, Jianmin; Sherman, Alexander; Smith, Russell B; Sherman, Simon

    2016-01-01

    A multicenter, web-based Thyroid Cancer and Tumor Collaborative Registry (TCCR, http://tccr.unmc.edu) allows for the collection and management of various data on thyroid cancer (TC) and thyroid nodule (TN) patients. The TCCR is coupled with OpenSpecimen, an open-source biobank management system, to annotate biospecimens obtained from the TCCR subjects. The demographic, lifestyle, physical activity, dietary habits, family history, medical history, and quality of life data are provided and may be entered into the registry by subjects. Information on diagnosis, treatment, and outcome is entered by the clinical personnel. The TCCR uses advanced technical and organizational practices, such as (i) metadata-driven software architecture (design); (ii) modern standards and best practices for data sharing and interoperability (standardization); (iii) Agile methodology (project management); (iv) Software as a Service (SaaS) as a software distribution model (operation); and (v) the confederation principle as a business model (governance). This allowed us to create a secure, reliable, user-friendly, and self-sustainable system for TC and TN data collection and management that is compatible with various end-user devices and easily adaptable to a rapidly changing environment. Currently, the TCCR contains data on 2,261 subjects and data on more than 28,000 biospecimens. Data and biological samples collected by the TCCR are used in developing diagnostic, prevention, treatment, and survivorship strategies against TC. PMID:27168721

  6. Thyroid Cancer and Tumor Collaborative Registry (TCCR).

    Science.gov (United States)

    Shats, Oleg; Goldner, Whitney; Feng, Jianmin; Sherman, Alexander; Smith, Russell B; Sherman, Simon

    2016-01-01

    A multicenter, web-based Thyroid Cancer and Tumor Collaborative Registry (TCCR, http://tccr.unmc.edu) allows for the collection and management of various data on thyroid cancer (TC) and thyroid nodule (TN) patients. The TCCR is coupled with OpenSpecimen, an open-source biobank management system, to annotate biospecimens obtained from the TCCR subjects. The demographic, lifestyle, physical activity, dietary habits, family history, medical history, and quality of life data are provided and may be entered into the registry by subjects. Information on diagnosis, treatment, and outcome is entered by the clinical personnel. The TCCR uses advanced technical and organizational practices, such as (i) metadata-driven software architecture (design); (ii) modern standards and best practices for data sharing and interoperability (standardization); (iii) Agile methodology (project management); (iv) Software as a Service (SaaS) as a software distribution model (operation); and (v) the confederation principle as a business model (governance). This allowed us to create a secure, reliable, user-friendly, and self-sustainable system for TC and TN data collection and management that is compatible with various end-user devices and easily adaptable to a rapidly changing environment. Currently, the TCCR contains data on 2,261 subjects and data on more than 28,000 biospecimens. Data and biological samples collected by the TCCR are used in developing diagnostic, prevention, treatment, and survivorship strategies against TC.

  7. Encouraging Health Information Management Graduates to Pursue Cancer Registry Careers.

    Science.gov (United States)

    Peterson, Jennifer

    2016-01-01

    The cancer registry profession has grown dramatically since its inception in 1926. Certified tumor registrars (CTRs) have become an integral part of the cancer care team by providing quality cancer data for research, statistical purposes, public health, and cancer control. In addition, CTRs have been found to be valuable in other cancer and health-related fields. Based on the need for high-quality, accurate data, the National Cancer Registrars Association (NCRA), the certification body for CTRs, has increased the educational requirement for eligibility for the CTR certification exam. This has resulted in fewer individuals who are able to meet the requirements for CTR certification. In addition, the existing cancer registry workforce is, on average, older than other allied health professions, and therefore will face an increasing number of retirements in the next few years. The high demand for CTRs, the decreased pool of CTR-eligible applicants, and the aging cancer registry workforce has resulted in an existing shortage that will only get worse as the population ages and the incidence of cancer increases. Health information management (HIM) students are well suited to pursuing further training in the cancer registry field and gaining the CTR credential. HIM students or new graduates have the needed skill set and education to pursue a cancer registry career. There are many avenues HIM educational programs can take to encourage students to pursue CTR certification and a cancer registry career. Including cancer registry functions in courses throughout the HIM curriculum, bringing in cancer registry speakers, encouraging networking, and promoting the cancer registry field and profession in general are just a few of the methods that HIM programs can use to raise awareness of and promote a cancer registry career to their students. Illinois State University has used these methods and has found them to be successful in encouraging a percentage of their graduates to pursue

  8. Cancer, Infant Mortality and Birth Sex-Ratio in Fallujah, Iraq 2005–2009

    OpenAIRE

    Malak Hamdan; Entesar Ariabi; Chris Busby

    2010-01-01

    There have been anecdotal reports of increases in birth defects and cancer in Fallujah, Iraq blamed on the use of novel weapons (possibly including depleted uranium) in heavy fighting which occurred in that town between US led forces and local elements in 2004. In Jan/Feb 2010 the authors organised a team of researchers who visited 711 houses in Fallujah, Iraq and obtained responses to a questionnaire in Arabic on cancer, birth defects and infant mortality. The total population in the resulti...

  9. Periviable birth: Interim update.

    Science.gov (United States)

    Ecker, Jeffrey L; Kaimal, Anjali; Mercer, Brian M; Blackwell, Sean C; deRegnier, Raye Ann O; Farrell, Ruth M; Grobman, William A; Resnik, Jamie L; Sciscione, Anthony C

    2016-08-01

    Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth. These include, but are not limited to, nonmodifiable factors (eg, fetal sex, weight, plurality), potentially modifiable antepartum and intrapartum factors (eg, location of delivery, intent to intervene by cesarean delivery or induction for delivery, administration of antenatal corticosteroids and magnesium sulfate), and postnatal management (eg, starting or withholding and continuing or withdrawing intensive care after birth). Antepartum and intrapartum management options vary depending upon the specific circumstances but may include short-term tocolytic therapy for preterm labor to allow time for administration of antenatal steroids, antibiotics to prolong latency after preterm premature rupture of membranes or for intrapartum group B streptococci prophylaxis, and delivery, including cesarean delivery, for concern regarding fetal well-being or fetal malpresentation. Whenever possible, periviable births for which maternal or neonatal intervention is planned should occur in centers that offer expertise in maternal and neonatal care and the needed infrastructure, including intensive care units, to support such services. This document describes newborn outcomes after periviable birth, provides current evidence and recommendations regarding interventions in this setting, and provides an outline for family counseling with the goal of

  10. Validity of Health Plan and Birth Certificate Data for Pregnancy Research

    Science.gov (United States)

    Andrade, Susan E.; Scott, Pamela E.; Davis, Robert L.; Li, De-Kun; Getahun, Darios; Cheetham, T. Craig; Raebel, Marsha A.; Toh, Sengwee; Dublin, Sascha; Pawloski, Pamala A.; Hammad, Tarek A.; Beaton, Sarah J.; Smith, David H.; Dashevsky, Inna; Haffenreffer, Katherine; Cooper, William O.

    2012-01-01

    Purpose To evaluate the validity of health plan and birth certificate data for pregnancy research. Methods A retrospective study was conducted using administrative and claims data from 11 U.S. health plans, and corresponding birth certificate data from state health departments. Diagnoses, drug dispensings, and procedure codes were used to identify infant outcomes (cardiac defects, anencephaly, preterm birth, and neonatal intensive care unit [NICU] admission) and maternal diagnoses (asthma and systemic lupus erythematosus [SLE]) recorded in the health plan data for live born deliveries between January 2001 and December 2007. A random sample of medical charts (n = 802) was abstracted for infants and mothers identified with the specified outcomes. Information on newborn, maternal, and paternal characteristics (gestational age at birth, birth weight, previous pregnancies and live births, race/ethnicity) was also abstracted and compared to birth certificate data. Positive predictive values (PPVs) were calculated with documentation in the medical chart serving as the gold standard. Results PPVs were 71% for cardiac defects, 37% for anencephaly, 87% for preterm birth, and 92% for NICU admission. PPVs for algorithms to identify maternal diagnoses of asthma and SLE were ≥ 93%. Our findings indicated considerable agreement (PPVs > 90%) between birth certificate and medical record data for measures related to birth weight, gestational age, prior obstetrical history, and race/ethnicity. Conclusions Health plan and birth certificate data can be useful to accurately identify some infant outcomes, maternal diagnoses, and newborn, maternal, and paternal characteristics. Other outcomes and variables may require medical record review for validation. PMID:22753079

  11. Pregestational body mass index is related to neonatal abdominal circumference at birth--a Danish population-based study

    DEFF Research Database (Denmark)

    Tanvig, M; Wehberg, S; Vinter, C A;

    2013-01-01

    OBJECTIVES: To examine the impact of maternal pregestational body mass index (BMI) and smoking on neonatal abdominal circumference (AC) and weight at birth. To define reference curves for birth AC and weight in offspring of healthy, nonsmoking, normal weight women. DESIGN: Population-based study....... SETTING: Data from the Danish Medical Birth Registry. POPULATION: All live singletons without congenital malformations in Denmark 2004-10. METHODS: Data on 366 886 singletons at 35(+0) to 41(+6)  weeks(+days) of gestation were extracted and analysed using multivariate linear regressions. MAIN OUTCOME...

  12. 76 FR 36896 - Notice of Establishment of a New Plant Protection and Quarantine Stakeholder Registry

    Science.gov (United States)

    2011-06-23

    ... Protection and Quarantine Stakeholder Registry AGENCY: Animal and Plant Health Inspection Service, USDA... of interest. FOR FURTHER INFORMATION CONTACT: For information on the PPQ Stakeholder Registry... Protection and Quarantine (PPQ) stakeholder registry is an email subscription service that allows...

  13. The growing number of hemophilia registries : Quantity vs. quality

    NARCIS (Netherlands)

    Keipert, C; Hesse, J; Haschberger, B; Heiden, M; Seitz, R; van den Berg, H M; Hilger, A

    2015-01-01

    Registries for rare diseases provide a tool for obtaining an overview of the clinical situation and can be used to discover points of improvement and to monitor long-term safety. Registries could also become a powerful tool to provide supporting information for marketing authorization. There is an u

  14. Heredity In Sarcoidosis - A Registry-Based Twin Study

    DEFF Research Database (Denmark)

    Sverrild, Asger; Backer, Vibeke; Kyvik, Kirsten Ohm;

    2008-01-01

    obtained from the Danish National Patient Registry or the Social Insurance Institution, Finland, registry of re-imbursed medication using the 8th and 10th editions of the International Classification of Diseases. Fisher's exact test was used to compare probandwise concordance rates in different zygosity...

  15. The 2006 ERA-EDTA Registry annual report: a precis

    NARCIS (Netherlands)

    V.S. Stel; A. Kramer; C. Zoccali; K.J. Jager

    2009-01-01

    Introduction: This paper provides a summary of the 2006 European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry report. Methods: Data on renal replacement therapy (RRT) were available from 50 national and regional registries in 28 countries in Europe and bordering

  16. Data quality in the Danish National Acute Leukemia Registry

    DEFF Research Database (Denmark)

    Ostgård, Lene Sofie Granfeldt; Nørgaard, Jan Maxwell; Severinsen, Marianne Tang;

    2013-01-01

    The Danish National Acute Leukemia Registry (DNLR) has documented coverage of above 98.5%. Less is known about the quality of the recorded data.......The Danish National Acute Leukemia Registry (DNLR) has documented coverage of above 98.5%. Less is known about the quality of the recorded data....

  17. Global Burden of Neural Tube Defects, Risk Factors, and Prevention

    Directory of Open Access Journals (Sweden)

    Joseph E

    2014-11-01

    Full Text Available Neural tube defects (NTDs, serious birth defects of the brain and spine usually resulting in death or paralysis, affect an estimated 300,000 births each year worldwide. Although the majority of NTDs are preventable with adequate folic acid consumption during the preconception period and throughout the first few weeks of gestation, many populations, in particular those in low and middle resource settings, do not have access to fortified foods or vitamin supplements containing folic acid. Further, accurate birth defects surveillance data, which could help inform mandatory fortification and other NTD prevention initiatives, are lacking in many of these settings. The burden of birth defects in South East Asia is among the highest in the world. Expanding global neural tube defects prevention initiatives can support the achievement of the United Nations Millennium Development Goal 4 to reduce child mortality, a goal which many countries in South East Asia are currently not poised to reach, and the 63rd World Health Assembly Resolution on birth defects. More work is needed to develop and implement mandatory folic acid fortification policies, as well as supplementation programs in countries where the reach of fortification is limited.

  18. Prevention of preterm birth.

    LENUS (Irish Health Repository)

    Flood, Karen

    2012-02-01

    Preterm birth (delivery before 37 completed weeks of gestation) is common and rates are increasing. In the past, medical efforts focused on ameliorating the consequences of prematurity rather than preventing its occurrence. This approach resulted in improved neonatal outcomes, but it remains costly in terms of both the suffering of infants and their families and the economic burden on society. Increased understanding of the pathophysiology of preterm labor has altered the approach to this problem, with increased focus on preventive strategies. Primary prevention is a limited strategy which involves public education, smoking cessation, improved nutritional status and avoidance of late preterm births. Secondary prevention focuses on recurrent preterm birth which is the most recognisable risk factor. Widely accepted strategies include cervical cerclage, progesterone and dedicated clinics. However, more research is needed to explore the role of antibiotics and anti-inflammatory treatments in the prevention of this complex problem.

  19. Study on the use of model life tables methodology in birth defect's life expectancy estimation:the case of Down's syndrome%模型生命表方法在出生缺陷患者预期寿命估算中的应用——以唐氏综合征为例

    Institute of Scientific and Technical Information of China (English)

    纪颖; 陈功; 郑晓瑛

    2008-01-01

    以唐氏综合征为例,研究采用Brass-Logit模型生命表的原理,通过美国一般人群的生命表、美国唐氏综合征患者的生命表、中国一般人群的生命表,间接估算中国唐氏综合征患者的生命表和预期寿命.经过与其他国家一般人群和唐氏综合征人群预期寿命的比较,研究认为,用Brass-Logit模型生命表原理来推算出生缺陷患者的生存状况和预期寿命,是在某一国家或地区的出生缺陷患者存活的数据非常缺乏、而另一些国家已有比较系统数据的情况下可以考虑使用的方法.%Using Brass-Logit model and life tables for general population and Down's syndrome patients in U.S.A and lire tables for general population in China,we estimated the life table of Down's syndrome patients in China.Through comparing with data from other countries,we suggested that BrassLogit Model Life Table could be adopted were minimum data of birth defects survival was available and systematic data was handy in another areas.

  20. Symptom Patterns Among Gulf War Registry Veterans

    Science.gov (United States)

    Hallman, William K.; Kipen, Howard M.; Diefenbach, Michael; Boyd, Kendal; Kang, Han; Leventhal, Howard; Wartenberg, Daniel

    2003-01-01

    Objectives. We identify symptom patterns among veterans who believe they suffer from Gulf War–related illnesses and characterize groups of individuals with similar patterns. Methods. A mail survey was completed by 1161 veterans drawn from the Gulf War Health Registry. Results. An exploratory factor analysis revealed 4 symptom factors. A K-means cluster analysis revealed 2 groups: (1) veterans reporting good health and few moderate/severe symptoms, and (2) veterans reporting fair/poor health and endorsing an average of 37 symptoms, 75% as moderate/severe. Those in Cluster 2 were more likely to report having 1 or more of 24 medical conditions. Conclusions. These findings are consistent with previous investigations of symptom patterns in Gulf War veterans. This multisymptom illness may be more fully characterized by the extent, breadth, and severity of symptoms reported. PMID:12660208

  1. Unsanctioned births in China.

    Science.gov (United States)

    Li, L; Ballweg, J A

    1995-05-01

    This study hypothesizes that "unsanctioned" births (beyond the limit authorized by the government) in China are more likely among couples who have strong traditional fertility norms and less likely among couples who adopt new family planning norms. The theoretical framework is based on cultural conflict theory as developed by Sellin. Data are obtained from 6654 ever married women aged under 49 years from the 1987 In-Depth Fertility Survey for Guangdong province. Over 30% of the sample were married before 20 years of age. 20% had 1 child, 26.7% had 2 children, about 23% had 3 children, 13.9% had 4 children, and under 10% had 5 or more children. The average number of living children was 2.5. Findings reveal that socioeconomic status was significantly related to unsanctioned births; they were more common in less developed areas and among women of lower socioeconomic status (SES). Persons living in areas with a high monetary contribution per person in family planning efforts at the county level were less likely to have unsanctioned births. Women who lived in urban areas, worked in state enterprises, and had parents with high educational status were less likely to have unsanctioned births. They were more likely among women who married at an early age, lived with parents after the marriage, had female living children, and had failed pregnancies. They were also more likely among women who had arranged marriages, a traditional desire for large family sizes, an early marriage ideal, and a preference for sons. Knowledge of family planning and greater use of abortion were related to a lower incidence of unsanctioned births. Women who talked with their husbands about their family size desires were less likely to have unsanctioned births. Parental educational attainment only had an influence among rural women. Variables impacted on fertility differently in urban and rural areas.

  2. Atrial – Ventricular Septal Defect

    Directory of Open Access Journals (Sweden)

    T Panagiotopoulos

    2009-05-01

    Full Text Available Atrial and ventricular septal defect constitute the most common congenital heart disease.Aim: Τhe aim of the present retrospective study was to record data and factors that affect atrial and ventricular septal defect.Method and material: The sample study included patients of both sexes who were hospitalized with diagnosis atrial and ventricular septal defect in a Cardiac Surgery hospital of Athens. A specially constructed printed form was used for data collection, where were recorded the demographic and personal variables, the pathological, surgical, cardiology and obstetric history, the habits of adults, as well as the personal characteristics of mothers. Analysis of data was performed by descriptive statistical analysis.Results: The sample study consisted of 101 individuals with diagnosis atrial or ventricular Septal Defect, of which 40% were boys and 60% girls. The 70% of the sample study suffered from atrial Septal Defect and the 30% suffered from ventricular Septal Defect. Regarding age, 12% of the sample study was 0-1 years old, 35% was >1 years old, 8% was >12-18 years old and 45% over than 18 years old. Regarding educational status of the adult participants, 9% was of 0-6 years education, 22%>6 -12 years, 13%>12 years. 14% of the adult paticipants smoked, 4% consumed alcohol and 5% smoked in conjunction with alcohol. In terms of the obstetric history of the sample studied, 32% of the cases had normal birth, 4% had a twin birth and 1% had a triplet one. According to the variables related to mothers, the mean age of the mother was 30 years and 3 months, 10% were smokers at pregnancy and 3% used chemical substance and mainly hair color. Also, the results of the present study showed that individuals of 12-18 and >18 years old did not suffer from ventricular Septal Defect, whereas the infants 0-1 years old did not suffer from Atrial Septal Defect. The mean value of age at the admission in intensive care unit was 7 months (12% for the infants

  3. I RBH - First Brazilian Hypertension Registry

    Science.gov (United States)

    Jardim, Paulo César Brandão Veiga; de Souza, Weimar Kunz Sebba Barroso; Lopes, Renato Delascio; Brandão, Andréa Araújo; Malachias, Marcus V. Bolívar; Gomes, Marco Mota; Moreno Júnior, Heitor; Barbosa, Eduardo Costa Duarte; Póvoa, Rui Manoel dos Santos

    2016-01-01

    Background: A registry assessing the care of hypertensive patients in daily clinical practice in public and private centers in various Brazilian regions has not been conducted to date. Such analysis is important to elucidate the effectiveness of this care. Objective: To document the current clinical practice for the treatment of hypertension with identification of the profile of requested tests, type of administered treatment, level of blood pressure (BP) control, and adherence to treatment. Methods: National, observational, prospective, and multicenter study that will include patients older than 18 years with hypertension for at least 4 weeks, following up in public and private centers and after signing a consent form. The study will exclude patients undergoing dialysis, hospitalized in the previous 30 days, with class III or IV heart failure, pregnant or nursing, with severe liver disease, stroke or acute myocardial infarction in the past 30 days, or with diseases with a survival prognosis < 1 year. Evaluations will be performed at baseline and after 1 year of follow-up. The parameters that will be evaluated include anthropometric data, lifestyle habits, BP levels, lipid profile, metabolic syndrome, and adherence to treatment. The primary outcomes will be hospitalization due to hypertensive crisis, cardiocirculatory events, and cardiovascular death, while secondary outcomes will be hospitalization for heart failure and requirement of dialysis. A subgroup analysis of 15% of the sample will include noninvasive central pressure evaluation at baseline and study end. The estimated sample size is 3,000 individuals for a prevalence of 5%, sample error of 2%, and 95% confidence interval. Results: The results will be presented after the final evaluation, which will occur at the end of a 1-year follow-up. Conclusion: The analysis of this registry will improve the knowledge and optimize the treatment of hypertension in Brazil, as a way of modifying the prognosis of

  4. The Twin Research Registry at SRI International.

    Science.gov (United States)

    Krasnow, Ruth E; Jack, Lisa M; Lessov-Schlaggar, Christina N; Bergen, Andrew W; Swan, Gary E

    2013-02-01

    The Twin Research Registry (TRR) at SRI International is a community-based registry of twins established in 1995 by advertising in local media, mainly on radio stations and in newspapers. As of August 2012, there are 3,120 same- and opposite-sex twins enrolled; 86% are 18 years of age or older (mean age 44.9 years, SD 16.9 years) and 14% less than 18 years of age (mean age 8.9 years, SD 4.5); 67% are female, and 62% are self-reported monozygotic (MZ). More than 1,375 twins have participated in studies over the last 15 years in collaboration with the University of California Medical Center in San Francisco, the University of Texas MD Anderson Cancer Center, and the Stanford University School of Medicine. Each twin completes a registration form with basic demographic information either online at the TRR Web site or during a telephone interview. Contact is maintained with members by means of annual newsletters and birthday cards. The managers of the TRR protect the confidentiality of twin data with established policies; no information is given to other researchers without prior permission from the twins; and all methods and procedures are reviewed by an Institutional Review Board. Phenotypes studied thus far include those related to nicotine metabolism, mutagen sensitivity, pain response before and after administration of an opioid, and a variety of immunological responses to environmental exposures, including second-hand smoke and vaccination for seasonal influenza virus and Varicella zoster virus. Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples. PMID:23084148

  5. Relationship between GDM maternal advanced glycation end products level and fetal birth defects and it's clinical significance%GDM孕妇血清晚期糖基化终产物水平与其胎儿出生缺陷的关系及临床意义

    Institute of Scientific and Technical Information of China (English)

    汤栩文; 林斯; 谢晓斌

    2012-01-01

    目的:检测妊娠期糖尿病(GDM)孕妇血清及脐血血清中晚期糖基化终产物(AGE)的水平,并观察胎盘组织中AGE受体(RAGE)的表达,探讨AGE与胎儿出生缺陷的关系及其在产前筛查中的临床意义.方法:选择经产前筛查诊断为胎儿畸形或胎死宫内的GDM孕妇作为病例组(42例),随机选择GDM无胎儿异常孕妇作为GDM组(30例),无妊娠合并症的健康孕妇作为健康对照组(30例).采用酶联免疫法检测孕妇血清及脐血血清AGE水平;采用免疫组化方法检测胎盘组织中RAGE蛋白的表达.结果:病例组、GDM组、健康对照组脐血血清AGE水平分别为(223.9±54.6),(160.7±37.2),(108.3+15.8) μg/L,三组差异显著(P<0.05);病例组、GDM组、健康对照组孕妇血清AGE水平分别为(169.1±14.3),(105.4±17.2),(80.6±11.4) μg/L,三组亦有显著差异(P<0.05);病例组孕妇血清与脐血血清中AGE水平呈正相关(r=0.863,P<0.01);病例组、GDM组及健康对照组胎盘组织中RAGE的阳性表达率分别为87.5%、53.1%、29.6%,三组差异显著(P<0.05).结论:GDM孕妇高AGE血症是导致出生缺陷的危险因素,孕妇血清AGE水平可作为GDM出生缺陷的产前筛查指标.%Objective:To detect serum advanced glycation end products(AGE) level in gestation diabetic mother( GDM) gestational period and fetal cord blood, and observe the RAGE protein expression in placenta. To explore the clinical significance of relationship be-tween fetal birth defects and AGE levels in prenatal screening. Methods: Gestational diabetes pregnant woman confirmed fetalmalformation or fetal death by prenatal diagnosis were enrolled as the study group, total of 42 cases; Randomly selected the GDM fetal normalities pregnant women,as the GDM group,30 cases;another 30 cases of the normal pregnant women wre select-ed randomly as healthy control group. Maternal peripheral blood and the specimens of fetal cord blood specimens were collected to detect AGE

  6. Latin American Dialysis and Transplant Registry: Experience and contributions to end-stage renal disease epidemiology.

    Science.gov (United States)

    Cusumano, Ana Maria; Rosa-Diez, Guillermo Javier; Gonzalez-Bedat, Maria Carlota

    2016-09-01

    In 2015, 634387 million people (9% of the world's population) resided in Latin America (LA), with half of those populating Brazil and Mexico. The LA Dialysis and Transplant Registry was initiated in 1991, with the aim of collecting data on renal replacement therapy (RRT) from the 20 LA-affiliated countries. Since then, the Registry has revealed a trend of increasing prevalence and incidence of end-stage kidney disease on RRT, which is ongoing and is correlated with gross national income, life expectancy at birth, and percentage of population that is older than 65 years. In addition, the rate of kidney transplantation has increased yearly, with > 70% being performed from deceased donors. According to the numbers reported for 2013, the rates of prevalence, incidence and transplantation were (in patients per million population) 669, 149 and 19.4, respectively. Hemodialysis was the treatment of choice (90%), and 43% of the patients undergoing this treatment was located in Brazil; in contrast, peritoneal dialysis prevailed in Costa Rica, El Salvador and Guatemala. To date, the Registry remains the only source of RRT data available to healthcare authorities in many LA countries. It not only serves to promote knowledge regarding epidemiology of end-stage renal disease and the related RRT but also for training of nephrologists and renal researchers, to improve understanding and clinical application of dialysis and transplantation services. In LA, accessibility to RRT is still limited and it remains necessary to develop effective programs that will reduce risk factors, promote early diagnosis and treatment of chronic kidney disease, and strengthen transplantation programs.

  7. KIR and HLA-C: Immunogenetic regulation of human birth weight

    Directory of Open Access Journals (Sweden)

    Lydia E. Farrell

    2014-12-01

    Full Text Available Pregnancies resulting in very small or very large babies are at higher risk of obstetric complications with increased morbidity for both mother and baby. Using data from the Medical Birth Registry of Norway we have shown how human birth weight is still subject to stabilizing selection. Particular combinations of maternal/fetal immune genes have been implicated in pregnancies resulting in a low birth weight baby (<5th birth weight centile. More specifically, an inhibitory maternal KIRAA genotype with a paternally derived fetal HLA-C2 ligand. At the other end of the birth weight spectrum the presence of an activating maternal KIR2DS1 gene is associated with increased birth weight in linear or logistic regression analyses of all pregnancies >5th centile (p=0.005, OR=2.65. Thus, inhibitory maternal KIR combined with fetal HLA-C2 is more frequently associated with low birth weight, whereas activating maternal KIR with fetal HLA-C2 ligand is associated with increasing birth weight. Our findings using the MoBa cohort have replicated the association of KIR and HLA-C seen in poor placentation, and confirm the importance of maternal/fetal immune gene interactions in determining the outcome of pregnancy.

  8. Glocal clinical registries: pacemaker registry design and implementation for global and local integration--methodology and case study.

    Directory of Open Access Journals (Sweden)

    Kátia Regina da Silva

    Full Text Available BACKGROUND: The ability to apply standard and interoperable solutions for implementing and managing medical registries as well as aggregate, reproduce, and access data sets from legacy formats and platforms to advanced standard formats and operating systems are crucial for both clinical healthcare and biomedical research settings. PURPOSE: Our study describes a reproducible, highly scalable, standard framework for a device registry implementation addressing both local data quality components and global linking problems. METHODS AND RESULTS: We developed a device registry framework involving the following steps: (1 Data standards definition and representation of the research workflow, (2 Development of electronic case report forms using REDCap (Research Electronic Data Capture, (3 Data collection according to the clinical research workflow and, (4 Data augmentation by enriching the registry database with local electronic health records, governmental database and linked open data collections, (5 Data quality control and (6 Data dissemination through the registry Web site. Our registry adopted all applicable standardized data elements proposed by American College Cardiology / American Heart Association Clinical Data Standards, as well as variables derived from cardiac devices randomized trials and Clinical Data Interchange Standards Consortium. Local interoperability was performed between REDCap and data derived from Electronic Health Record system. The original data set was also augmented by incorporating the reimbursed values paid by the Brazilian government during a hospitalization for pacemaker implantation. By linking our registry to the open data collection repository Linked Clinical Trials (LinkedCT we found 130 clinical trials which are potentially correlated with our pacemaker registry. CONCLUSION: This study demonstrates how standard and reproducible solutions can be applied in the implementation of medical registries to constitute a re

  9. Girl with Zika Birth Defect Born At New Jersey Hospital

    Science.gov (United States)

    ... health officials have said they expect to see Zika infections in Gulf Coast states such as Florida, Louisiana and Texas as mosquito season picks up. Mosquito bites remain the most common source of infection of the Zika virus. But transmission of the virus through sex ...

  10. CDC Concludes Zika Causes Microcephaly and Other Birth Defects

    Science.gov (United States)

    ... means that a woman who is infected with Zika during pregnancy has an increased risk of having a baby ... not mean, however, that all women who have Zika virus infection during pregnancy will have babies with problems. As has been ...

  11. Birth Defects: What They Are and How They Happen

    Science.gov (United States)

    ... Sickle cell disease and your baby Spina bifida Tay-Sachs and Sandhoff diseases Thalassemia Treatment of amino acid ... Sickle cell disease and your baby Spina bifida Tay-Sachs and Sandhoff diseases Thalassemia Treatment of amino acid ...

  12. Treatment of Hyperthyroidism in Pregnancy and Birth Defects

    NARCIS (Netherlands)

    Clementi, Maurizio; Di Gianantonio, Elena; Cassina, Matteo; Leoncini, Emanuele; Botto, Lorenzo D.; Mastroiacovo, Pierpaolo

    2010-01-01

    Context: Clinical hyperthyroidism is not uncommon in pregnancy, with a reported prevalence of 0.1 to 0.4%. The available antithyroid drugs are propylthiouracil and methimazole/carbimazole. Objectives: In this report we examined the association of both drugs with congenital malformations using data f

  13. High Prevalence of Associated Birth Defects in Congenital Hypothyroidism

    OpenAIRE

    Alok Sachan; V. Suresh; D Rajasekhar; V. Vanaja; Harinarayan, C. V.; Rajagopal, G.; P Amaresh Reddy

    2010-01-01

    Aim. To identify dysmorphic features and cardiac, skeletal, and urogenital anomalies in patients with congenital hypothyroidism. Patients and Methods. Seventeen children with congenital primary hypothyroidism were recruited. Cause for congenital hypothyroidism was established using ultrasound of thyroid and T99mc radionuclide thyroid scintigraphy. Malformations were identified by clinical examination, echocardiography, X-ray of lumbar spine, and ultrasonography of abdomen. Results. Ten (59...

  14. How Do Health Care Providers Diagnose Birth Defects?

    Science.gov (United States)

    ... amniocentesis are Down syndrome and certain types of muscular dystrophy . Because amniocentesis can cause a miscarriage in about 1 out of 200 cases, it is usually only recommended for pregnancies in which the risk of genetic disorders or other problems is high. Chorionic Villus ...

  15. Births: Final Data for 2014.

    Science.gov (United States)

    Hamilton, Brady E; Martin, Joyce A; Osterman, Michelle J K; Curtin, Sally C; Matthews, T J

    2015-12-01

    This report presents 2014 data on U.S. births according to a wide variety of characteristics. Data are presented for maternal age, live-birth order, race and Hispanic origin, marital status, attendant at birth, method of delivery, period of gestation, birthweight, and plurality. Birth and fertility rates are presented by age, live-birth order, race and Hispanic origin, and marital status. Selected data by mother's state of residence and birth rates by age and race of father also are shown. Trends in fertility patterns and maternal and infant characteristics are described and interpreted. PMID:26727629

  16. A multinational case-control study on childhood brain tumours, anthropogenic factors, birth characteristics and prenatal exposures: A validation of interview data.

    Science.gov (United States)

    Vienneau, Danielle; Infanger, Denis; Feychting, Maria; Schüz, Joachim; Schmidt, Lisbeth Samsø; Poulsen, Aslak Harbo; Tettamanti, Giorgio; Klæboe, Lars; Kuehni, Claudia E; Tynes, Tore; Von der Weid, Nicolas; Lannering, Birgitta; Röösli, Martin

    2016-02-01

    Little is known about the aetiology of childhood brain tumours. We investigated anthropometric factors (birth weight, length, maternal age), birth characteristics (e.g. vacuum extraction, preterm delivery, birth order) and exposures during pregnancy (e.g. maternal: smoking, working, dietary supplement intake) in relation to risk of brain tumour diagnosis among 7-19 year olds. The multinational case-control study in Denmark, Sweden, Norway and Switzerland (CEFALO) included interviews with 352 (participation rate=83.2%) eligible cases and 646 (71.1%) population-based controls. Interview data were complemented with data from birth registries and validated by assessing agreement (Cohen's Kappa). We used conditional logistic regression models matched on age, sex and geographical region (adjusted for maternal age and parental education) to explore associations between birth factors and childhood brain tumour risk. Agreement between interview and birth registry data ranged from moderate (Kappa=0.54; worked during pregnancy) to almost perfect (Kappa=0.98; birth weight). Neither anthropogenic factors nor birth characteristics were associated with childhood brain tumour risk. Maternal vitamin intake during pregnancy was indicative of a protective effect (OR 0.75, 95%-CI: 0.56-1.01). No association was seen for maternal smoking during pregnancy or working during pregnancy. We found little evidence that the considered birth factors were related to brain tumour risk among children and adolescents. PMID:26625087

  17. The Birth of "Frankenstein"

    Science.gov (United States)

    Howard, Jennifer

    2008-01-01

    Nobody shouts "It's alive!" in the novel that gave birth to Frankenstein's monster. "Frankenstein, or the Modern Prometheus," does not feature mad scientists messing around with beakers in laboratories, nor does it deliver any bug-eyed assistants named Igor. Hollywood has given people those stock images, but the story of the monster and his maker…

  18. The Birth Order Puzzle.

    Science.gov (United States)

    Zajonc, R. B.; And Others

    1979-01-01

    Discusses the controversy of the relationship between birth order and intellectual performance through a detailed evaluation of the confluence model which assumes that the rate of intellectual growth is a function of the intellectual environment within the family and associated with the special circumstances of last children. (CM)

  19. Birth Order Debate Resolved?

    Science.gov (United States)

    Zajonc, R. B.

    2001-01-01

    Critiques Rodgers et al.'s June 2000 research on the relation between birth order and intelligence, which suggests that it is a methodological illusion. Explains how the intellectual environment and the teaching function (whereby older children tutor younger ones) contribute to the growth of intellectual maturity, the first negatively and the…

  20. Cesarean Section Birth

    Medline Plus

    Full Text Available CESAREAN SECTION SHAWNEE MISSION MEDICAL CENTER MERRIAM, KANSAS March 13, 2008 00:00:09 ANNOUNCER: Tonight you will experience the miracle of birth during a live Internet broadcast from Shawnee Mission Medical Center in Merriam, Kansas. Over the next hour, ...

  1. Parental age and Neurofibromatosis Type 1: a report from the NF1 Patient Registry Initiative.

    Science.gov (United States)

    Liu, Qian; Zoellner, Nancy; Gutmann, David H; Johnson, Kimberly J

    2015-06-01

    One of the potential etiologies for non-familial Neurofibromatosis Type 1 (NF1) is increasing parental age. We sought to evaluate recent evidence for parental age effects in NF1 in a large study. Individuals with NF1 and a comparison group from the U.S. general population born between 1994 and 2012 were ascertained from the NF1 Patient Registry Initiative (NPRI) and the National Center for Vital Statistics, respectively. Multiple linear regression analysis was employed to identify differences between familial NF1, non-familial NF1, and U.S. population subjects in the mean parental ages at the time of the birth of offspring in each group. In addition, we also evaluated the effect of parental age on NF1 offspring with and without a pediatric brain tumor history. A total of 313 subjects from the NPRI (including 99 brain tumor cases) matched by birth year at a 1:3 ratio to U.S. general population births (n = 939) were included. Compared to the U.S. general population and familial NF1 cases, the mean paternal age for non-familial NF1 cases was 4.34 years (95% CI 3.23-5.46, p ≤ 0.0001) and 3.39 years (95% CI 1.57-5.20, p ≤ 0.0001) older, respectively, after adjusting for birth year. A similar pattern was observed for maternal age. There were no statistically significant differences in the mean maternal or paternal ages between NF1 offspring with and without a pediatric brain tumor. In conclusion, these data support a parental age effect for non-familial NF1 cases, but not for pediatric brain tumors in NF1. PMID:25523354

  2. 低龄低体重患儿经胸小切口封堵膜周部室间隔缺损的策略及早期疗效%Strategy and Short-term Outcomes of Transthoraic Occlusion via a Small Incision in Low Birth-weight Infants with Ventricular Septal Defect

    Institute of Scientific and Technical Information of China (English)

    李小波; 万亚红; 邬云龙; 肖明第

    2012-01-01

    To study the surgical techniques and efficacy of transthoracic occlusion through a small chest incision for low birth-weight infants with ventricular septal defect (VSD). Methods Totally 51 low birth-weight infants with VSD, who received transthoracic occlusion in our hospital during October 2010 to November 2011, were enrolled into this study. The shunt diameter was 4-8 mm, as shown by echocardiography, and was over 1 mm away from the aortic valve. The patients aged from 4 to 12 months with a mean of (8.6 ±2. 1) months; the mean body weight was (7.4 ±2. 1) kg (ranged from 6 to 11 kg). Via a 4- to 5-mm incision below the sternum, under the guidance by TEE, we introduced a guide wire through the right ventricular anterior wall, and then placed occlusion device at the VSD site. The surgical procedure and efficacy was analyzed retrospectively afterwards. Results No mortality occurred during peri-operative period. The success rate of transthoracic occlusion was 90% (46/51). The five patients, who failed in the procedure, were transferred to cardiopulmonary bypass (CPB) for a VSD repair in a direct surgical field. In the 46 successful cases, no residual leakage, dislocation of occlusion device, or arrhythmia occurred; echocardiography showed no aortic regurgitation, however, 5 (13%) patients developed mild tricuspid valve regurgitation. Three patients (5. 8%) received blood transfusion of 50 ml. The patients were discharged from hospital in a mean of (3. 9 ± 0. 7) days (ranged from 3 to 7 days). Afterwards, all the 46 successful cases were followed up for (3. 6 ± 1. 4) months ( ranged from 1 to 12 months) , during which no patient died,and ECG, echocardiography, and chest X-ray found nothing abnormal, the cardiac faction was in grade I in all the cases. Conclusions For low birth-weight infants with VSD with a shunt diameter of 4 - 8 mm, and > 1 mm away from the aortic valve, transthoracic occlusion through a small chest incision is feasible and effective.%目的

  3. Navajo birth outcomes in the Shiprock uranium mining area

    International Nuclear Information System (INIS)

    The role of environmental radiation in the etiology of birth defects, stillbirths, and other adverse outcomes of pregnancy was evaluated for 13,329 Navajos born at the Public Health Service/Indian Health Service Hospital in the Shiprock, NM, uranium mining area (1964-1981). More than 320 kinds of defective congenital conditions were abstracted from hospital records. Using a nested case-control design, families of 266 pairs of index and control births were interviewed. The only statistically significant association between uranium operations and unfavorable birth outcome was identified with the mother living near tailings or mine dumps. Among the fathers who worked in the mines, those of the index cases had histories of more years of work exposure but not necessarily greater gonadal dosage of radiation. Also, birth defects increased significantly when either parent worked in the Shiprock electronics assembly plant. Overall, the associations between adverse pregnancy outcome and exposure to radiation were weak and must be interpreted with caution with respect to implying a biogenetic basis

  4. Screening for spontaneous preterm birth

    NARCIS (Netherlands)

    M.A. van Os; A.J.E.M. van Dam

    2015-01-01

    Preterm birth is the most important cause of perinatal morbidity and mortality worldwide. In this thesis studies on spontaneous preterm birth are presented. The main objective was to investigate the predictive capacity of mid-trimester cervical length measurement for spontaneous preterm birth in a l

  5. EPA Facility Registry Service (FRS): CERCLIS_NPL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that are...

  6. EPA Facility Registry Service (FRS): ER_TRI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  7. EPA Facility Registry Service (FRS): ER_WWTP_NPDES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of Waste Water Treatment...

  8. EPA Facility Registry Service (FRS): ER_RMP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  9. EPA Facility Registry Service (FRS): PCS_NPDES_MAJOR

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that are...

  10. EPA Facility Registry Service (FRS): Wastewater Treatment Plants

    Data.gov (United States)

    U.S. Environmental Protection Agency — This GIS dataset contains data on wastewater treatment plants, based on EPA's Facility Registry Service (FRS), EPA's Integrated Compliance Information System (ICIS)...

  11. EPA Facility Registry Service (FRS): RCRA_TRANS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  12. Clinical features of paediatric pulmonary hypertension : a registry study

    NARCIS (Netherlands)

    Berger, Rolf M. F.; Beghetti, Maurice; Humpl, Tilman; Raskob, Gary E.; Ivy, D. Dunbar; Jing, Zhi-Cheng; Bonnet, Damien; Schulze-Neick, Ingram; Barst, Robyn J.

    2012-01-01

    Background Paediatric pulmonary hypertension, is an important cause of morbidity and mortality, and is insufficiently characterised in children. The Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension (TOPP) registry is a global, prospective study designed to provide information about

  13. EPA Facility Registry Service (FRS): AIRS_AQS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  14. EPA Facility Registry Service (FRS): AIRS_AFS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  15. EPA Facility Registry Service (FRS): ER_RCRATSD

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  16. EPA Facility Registry Service (FRS): PCS_NPDES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  17. EPA Facility Registry Service (FRS): ER_FRP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link to Facility...

  18. EPA Facility Registry Service (FRS): RCRA_LQG

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  19. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable data package consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are...

  20. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in...