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Sample records for birth defects registry

  1. Birth defects registries in the genomics era: challenges and opportunities for developing countries.

    Science.gov (United States)

    Thong, Meow-Keong

    2014-01-01

    Birth defects or congenital anomalies are one of the major causes of disability in developed and developing countries. Data on birth defects from population-based studies originating from developing countries are lacking. Increasingly, there is a shift to genetic testing and genomics study of birth defects. However, the translation from bench findings to bedside medicine has been muted. There is a need to address this imbalance where congenital anomalies remained the top etiology for neonatal mortality in developing countries. To build capacity in low resource countries, there is a need for accurate collection and ascertainment of birth defects in developing countries. The systematic collection and analysis of data on major birth defects using birth defects registries (BDRs) are an integral part of all clinical genetic services. Healthcare planners in developing countries must be aware of the advantages and limitations of BDRs. Despite the advent of the genomics era, BDRs are essential to the planning and developing care and prevention services at local and national levels, particularly in low resource or developing countries.

  2. Congenital malformations in Ecuadorian children: urgent need to create a National Registry of Birth Defects

    Directory of Open Access Journals (Sweden)

    Fabricio González-Andrade

    2010-04-01

    Full Text Available Fabricio González-Andrade1, Ramiro López-Pulles21Department of Medicine, Metropolitan Hospital, Quito, Ecuador; 2Science and Technology Process of the Ministry of Public Health, Biomedical Center of the Central University and Regional Autonomic University of the Audes, Quito, Ecuador Universidad Central del Ecuador, Quito, EcuadorAim: This study sets out (a to estimate the prevalence of admissions by birth defects, using the official database of hospitals of Ecuador; and (b to set the basis for a new National Register of Birth Defects in Ecuador that works as a program for the clinical and epidemiological investigation of risk factors in the etiology of congenital anomalies in Ecuadorian hospitals, using a case-control methodological approach. This is the first report in their class.Methods: The data used in this study are derived from the National Register of Hospital Admission/Discharges of the Instituto Nacional de Estadísticas y Censos; data of the Ministry of Public Health were also used. Ecuador does not have an official Medical Birth Registry or a Congenital Malformations Registry.Results: A total of 51,375 discharges by congenital malformations were registered in a 7-year period. Of these, 16,679 admissions were of children aged less than 1 year of age, with a birth prevalence rate (BPR of 72.33/10,000 births. 77% of the congenital defects registered comprise the 50 most common birth defects observed in this age group. Cleft lip was the most prevalent birth defect in children less than 1 year of age and the second most common defect in children 1 to 5 years of age. Unilateral cleft lip shows a BPR of 4.57/10,000 births; cardiac birth defects as a group have a BPR of 4.2; hydrocephalus a BPR of 3.77; and Down’s syndrome a BPR of 3.70. Undescended testicle was the most prevalent birth defect in children between 1 to 5 years. 9384 children under 1 year of age were male (55.9% and 7053 were female (42.1%. BPR in males was 40.45 and in

  3. Department of Defense Birth and Infant Health Registry: Birth Defects Among Infants Born to US Military Families: 2001 Annual Report

    Science.gov (United States)

    2008-05-30

    large intestinal atresia/stenosis 751.2 Anophthalmia/microphthalmia 743.0, 743.1 Pyloric stenosis 750.5 Congenital cataract 743.30-743.34...occurred in US military families worldwide. Data on birth defects were gathered using nationally standardized definitions for major congenital ...745.4 Congenital hip dislocation 754.30, .31, .35 Atrial septal defect 745.5 Reduction deformity, upper limbs 755.20-755.29 Endocardial cushion

  4. Methodological approaches to evaluate teratogenic risk using birth defect registries: advantages and disadvantages.

    Directory of Open Access Journals (Sweden)

    Fernando A Poletta

    Full Text Available BACKGROUND: Different approaches have been used in case-control studies to estimate maternal exposure to medications and the risk of birth defects. However, the performance of these approaches and how they affect the odds ratio (OR estimates have not been evaluated using birth-defect surveillance programmes. The aim of this study was to evaluate the scope and limitations of three case-control approaches to assess the teratogenic risk of birth defects in mothers exposed to antiepileptic medications, insulin, or acetaminophen. METHODOLOGY/PRINCIPAL FINDINGS: We studied 110,814 non-malformed newborns and 58,514 live newborns with birth defects registered by the Latin American Collaborative Study of Congenital Anomalies (ECLAMC between 1967 and 2008. Four controls were randomly selected for each case in the same hospital and period, and three different control groups were used: non-malformed newborns (HEALTHY, malformed newborns (SICK, and a subgroup of SICK, only-exposed cases (OECA. Associations were evaluated using OR and Pearson's chi-square (P<0.01. There were no concordance correlations between the HEALTHY and OECA designs, and the average OR differences ranged from 3.0 to 11.5 for the three evaluated medicines. The overestimations observed for HEALTHY design were increased as higher OR values were given, with a high and statistically significant correlation between the difference and the mean. On the contrary, the concordance correlations obtained between the SICK and OECA designs were quite good, with no significant differences in the average risks. CONCLUSIONS: The HEALTHY design estimates the true population OR, but shows a high rate of false-positive results presumably caused by differential misclassification bias. This bias decreases with the increase of the proportion of exposed controls. SICK and OECA odds ratios cannot be considered a direct estimate of the true population OR except under certain conditions. However, the SICK and OECA

  5. Methodological Approaches to Evaluate Teratogenic Risk Using Birth Defect Registries: Advantages and Disadvantages

    Science.gov (United States)

    Poletta, Fernando A.; López Camelo, Jorge S.; Gili, Juan A.; Leoncini, Emmanuele; Castilla, Eduardo E.; Mastroiacovo, Pierpaolo

    2012-01-01

    Background Different approaches have been used in case-control studies to estimate maternal exposure to medications and the risk of birth defects. However, the performance of these approaches and how they affect the odds ratio (OR) estimates have not been evaluated using birth-defect surveillance programmes. The aim of this study was to evaluate the scope and limitations of three case-control approaches to assess the teratogenic risk of birth defects in mothers exposed to antiepileptic medications, insulin, or acetaminophen. Methodology/Principal Findings We studied 110,814 non-malformed newborns and 58,514 live newborns with birth defects registered by the Latin American Collaborative Study of Congenital Anomalies (ECLAMC) between 1967 and 2008. Four controls were randomly selected for each case in the same hospital and period, and three different control groups were used: non-malformed newborns (HEALTHY), malformed newborns (SICK), and a subgroup of SICK, only-exposed cases (OECA). Associations were evaluated using OR and Pearson's chi-square (P<0.01). There were no concordance correlations between the HEALTHY and OECA designs, and the average OR differences ranged from 3.0 to 11.5 for the three evaluated medicines. The overestimations observed for HEALTHY design were increased as higher OR values were given, with a high and statistically significant correlation between the difference and the mean. On the contrary, the concordance correlations obtained between the SICK and OECA designs were quite good, with no significant differences in the average risks. Conclusions The HEALTHY design estimates the true population OR, but shows a high rate of false-positive results presumably caused by differential misclassification bias. This bias decreases with the increase of the proportion of exposed controls. SICK and OECA odds ratios cannot be considered a direct estimate of the true population OR except under certain conditions. However, the SICK and OECA designs could

  6. Final results from the Betaseron (interferon β-1b) Pregnancy Registry: a prospective observational study of birth defects and pregnancy-related adverse events

    Science.gov (United States)

    Coyle, P K; Sinclair, S M; Scheuerle, A E; Thorp, J M; Albano, J D; Rametta, M J

    2014-01-01

    Objective Women with multiple sclerosis are often diagnosed and treated during their reproductive years. Limited data are available on the safety of treatment during pregnancy. The Betaseron Pregnancy Registry prospectively monitored women exposed to interferon β-1b (IFNβ-1b) during pregnancy to estimate the rates of birth defects, spontaneous abortions (SABs) and other negative outcomes in this population. Design From 2006 to 2011, this observational registry enrolled women exposed prior to conception or during pregnancy (but prior to or without abnormalities on prenatal screening). Follow-up continued from enrolment through the 4-month paediatric visit. Setting Patients in the USA who met these criteria were enrolled in the registry. Results The registry enrolled 99 pregnant women; 3 were lost to follow-up. The earliest exposure to IFNβ-1b occurred during the first trimester for 95 pregnancies and in the third trimester for 1 pregnancy. There were 99 birth outcomes (3 twins), including 86 (86.9%) live births, 11 (11.1%) SABs and 2 (2%) stillbirths. Birth defects were reported in five (5.1%) cases. Rates of birth defects and SAB were not significantly different from population comparators. No developmental concerns were identified at the 4-month paediatric visit. Conclusions The small sample size limits the ability to draw definitive conclusions; however, there was no pattern to suggest increased negative outcomes with IFNβ-1b. Clinical trials registration number NCT00317564. PMID:24821713

  7. Birth Defects (For Parents)

    Science.gov (United States)

    ... this virus during pregnancy, her child may have low birth weight, intellectual disability (mental retardation) or learning disabilities, ... and central nervous system problems. A child with late congenital syphilis may have abnormalities of the ... Diagnosing Birth Defects Many birth defects are diagnosed even before ...

  8. Birth Defects Research and Tracking

    Science.gov (United States)

    ... used data from the National Birth Defects Prevention Study (NBDPS) to examine maternal asthma medication use during pregnancy and the risk of certain birth defects. (Published October 22, 2014) World Down Syndrome Day Read one mother’s reflection on the birth ...

  9. Diabetes mellitus and birth defects

    Science.gov (United States)

    Correa, Adolfo; Gilboa, Suzanne M.; Besser, Lilah M.; Botto, Lorenzo D.; Moore, Cynthia A.; Hobbs, Charlotte A.; Cleves, Mario A.; Riehle-Colarusso, Tiffany J.; Waller, D. Kim; Reece, E. Albert

    2016-01-01

    OBJECTIVE The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects. STUDY DESIGN This was a multicenter case-control study of mothers of infants who were born with (n = 13,030) and without (n = 4895) birth defects in the National Birth Defects Prevention Study (1997–2003). RESULTS Pregestational diabetes mellitus (PGDM) was associated significantly with noncardiac defects (isolated, 7/23 defects; multiples, 13/23 defects) and cardiac defects (isolated, 11/16 defects; multiples, 8/16 defects). Adjusted odds ratios for PGDM and all isolated and multiple defects were 3.17 (95% CI, 2.20–4.99) and 8.62 (95% CI, 5.27–14.10), respectively. Gestational diabetes mellitus (GDM) was associated with fewer noncardiac defects (isolated, 3/23 defects; multiples, 3/23 defects) and cardiac defects (isolated, 3/16 defects; multiples, 2/16 defects). Odds ratios between GDM and all isolated and multiple defects were 1.42 (95% CI, 1.17–1.73) and 1.50 (95% CI, 1.13–2.00), respectively. These associations were limited generally to offspring of women with prepregnancy body mass index ≥25 kg/m2. CONCLUSION PGDM was associated with a wide range of birth defects; GDM was associated with a limited group of birth defects. PMID:18674752

  10. Facts about Birth Defects

    Science.gov (United States)

    ... Heart Defects Atrial Septal Defect Atrioventricular Septal Defect Coarctation of the Aorta D-Transposition of the Great ... Defects Fetal Alcohol Syndrome Disorders Gastroschisis Heart Defects Coarctation of the Aorta Hypoplastic left heart syndrome Tetralogy ...

  11. The spatial evaluation of neighborhood clusters of birth defects

    Energy Technology Data Exchange (ETDEWEB)

    Frisch, J.D.

    1990-04-16

    Spatial statistics have recently been applied in epidemiology to evaluate clusters of cancer and birth defects. Their use requires a comparison population, drawn from the population at risk for disease, that may not always be readily available. In this dissertation the plausibility of using data on all birth defects, available from birth defects registries, as a surrogate for the spatial distribution of all live births in the analysis of clusters is assessed. Three spatial statistics that have been applied in epidemiologic investigations of clusters, nearest neighbor distance, average interpoint distance, and average distance to a fixed point, were evaluated by computer simulation for their properties in a unit square, and in a zip code region. Comparison of spatial distributions of live births and birth defects was performed by drawing samples of live births and birth defects from Santa Clara County, determining the street address at birth, geocoding this address and evaluating the resultant maps using various statistical techniques. The proposed method was then demonstrated on a previously confirmed cluster of oral cleft cases. All live births for the neighborhood were geocoded, as were all birth defects. Evaluation of this cluster using the nearest neighbor and average interpoint distance statistics was performed using randomization techniques with both the live births population and the birth defect population as comparison groups. 113 refs., 36 figs., 16 tabs.

  12. Intrauterine Infections and Birth Defects

    Institute of Scientific and Technical Information of China (English)

    XIAO-YING ZHENG; XIN-MING SONG; LI-HUA PANG; YING JI; HONG-MEI SUN; LEI ZHANG; JU-FEN LIU; YAN-LING GUO; YAN ZHANG; TING ZHANG; YI-FEI WANG; CHEN XU; GONG CHEN; RUOLEI XIN; JIA-PENG CHEN; XU-MEI HU; QING YANG

    2004-01-01

    Intrauterine infection is an important cause of some birth defects worldwide. The most common pathogens include rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. General information about these pathogens in epidemiology, consequence of birth defects, and the possible mechanisms in the progress of birth defects, and the interventions to prevent or treat these pathogens' infections are described. The infections caused by rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. are common, yet they are proved to be fatal during the pregnant period, especially during the first trimester. These infections may cause sterility, abortion, stillbirth, low birth weight, and affect multiple organs that may induce loss of hearing and vision, even fetal deformity and the long-term effects. These pathogens' infections may influence the microenvironment of placenta, including levels of enzymes and cytokines, and affect chondriosome that may induce the progress of birth defect. Early diagnosis of infections during pregnancy should be strengthened. There are still many things to be settled, such as the molecular mechanisms of birth defects, the effective vaccines to certain pathogens. Birth defect researches in terms of etiology and the development of applicable and sensitive pathogen detection technology and methods are imperative.

  13. Seasonality in birth defects, agricultural production and urban location.

    Science.gov (United States)

    McKinnish, Terra; Rees, Daniel I; Langlois, Peter H

    2014-12-01

    This paper tests whether the strength of the "spring spike" in birth defects is related to agricultural production and urban location using Texas Birth Defects Registry data for the period 1996-2007. We find evidence of a spike in birth defects among children conceived in the spring and summer, but it is more pronounced in urban non-agricultural counties than in other types of counties. Furthermore, the spike lasts longer in urban non-agricultural counties as compared to other types of counties.

  14. Fluoxetine and infantile hypertrophic pylorus stenosis : a signal from a birth defects drug exposure surveillance study

    NARCIS (Netherlands)

    Bakker, M.K.; de Walle, H.E.K.; Wilffert, B.; de Jong-van den Berg, L.T.W.

    2010-01-01

    Purpose We report an association found in a surveillance study which systematically evaluated combinations of specific birth defects and drugs used in the first trimester of pregnancy. Method The database of a population-based birth defects registry (birth years 1997-2007) was systematically screene

  15. Alarming Rise In Birth Defects

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A rapid rise in birth defects has prompted China to look for causes and solutionsEvery 60 seconds two children are born in China with a handicap.It’s an alarming fact,but one that young adults across the country who hope to have children face every day. At a conference on the prevention of birth defects in Chengdu of Sichuan Province in September,Vice Minister of the National Population and Family Planning Commission Jiang Fan revealed this inconvenient truth, supported by shocking statistics.

  16. RESIDENTIAL RADON AND BIRTH DEFECTS: A POPULATION-BASED ASSESSMENT

    Science.gov (United States)

    Langlois, Peter H; Lee, MinJae; Lupo, Philip J; Rahbar, Mohammad H; Cortez, Ruben K

    2015-01-01

    BACKGROUND Associations have been reported between maternal radiation exposure and birth defects. No such studies were found on radon. Our objective was to determine if there is an association between living in areas with higher radon levels and birth defects. METHODS The Texas Birth Defects Registry provided data on all birth defects from 1999–2009 from the entire state. Mean radon levels by geologic region came from the Texas Indoor Radon Survey. The association between radon and birth defects was estimated using multilevel mixed effect Poisson regression. RESULTS Birth defects overall were not associated with residential radon levels. Of the 100 other birth defect groups with at least 500 cases, 14 were significantly elevated in areas with high mean radon level in crude analyses, and 9 after adjustment for confounders. Cleft lip with/without cleft palate had an adjusted prevalence ratio (aPR) of 1.16 per 1 picoCurie/liter (pCi/l) increase in exposure to region mean radon, 95% confidence interval (CI) 1.08, 1.26. Cystic hygroma / lymphangioma had an aPR of 1.22 per 1 pCi/l increase, 95% CI 1.02, 1.46. Other associations were suggested but not as consistent: three skeletal defects, Down syndrome, other specified anomalies of the brain, and other specified anomalies of the bladder and urethra. CONCLUSIONS In the first study of residential radon and birth defects, we found associations with cleft lip w/wo cleft palate and cystic hygroma / lymphangioma. Other associations were suggested. The ecological nature of this study and multiple comparisons suggest that our results be interpreted with caution. PMID:25846606

  17. Microcephaly and Other Birth Defects: Zika

    Science.gov (United States)

    ... ol Português Recommend on Facebook Tweet Share Compartir Zika and Microcephaly Microcephaly is a birth defect in ... pregnancy or has stopped growing after birth. Congenital Zika Syndrome Congenital Zika syndrome is a pattern of ...

  18. Birth defects and genetic disorders among Arab Americans--Michigan, 1992-2003.

    Science.gov (United States)

    Yanni, Emad A; Copeland, Glenn; Olney, Richard S

    2010-06-01

    Birth defects and genetic disorders are leading causes of infant morbidity and mortality in many countries. Population-based data on birth defects among Arab-American children have not been documented previously. Michigan has the second largest Arab-American community in the United States after California. Using data from the Michigan Birth Defects Registry (MBDR), which includes information on parents' country of birth and ancestry, birth prevalences were estimated in offspring of Michigan women of Arab ancestry for 21 major categories of birth defects and 12 congenital endocrine, metabolic, and hereditary disorders. Compared with other non-Hispanic white children in Michigan, Arab-American children had similar or lower birth prevalences of the selected types of structural birth defects, with higher rates of certain hereditary blood disorders and three categories of metabolic disorders. These estimates are important for planning preconception and antenatal health care, genetic counseling, and clinical care for Arab Americans.

  19. Paternal occupation and birth defects: findings from the National Birth Defects Prevention Study.

    NARCIS (Netherlands)

    Desrosiers, T.A.; Herring, A.H.; Shapira, S.K.; Hooiveld, M.; Luben, T.J.; Herdt-Losavio, M.L.; Lin, S.; Olshan, A.F.

    2012-01-01

    Objectives: Several epidemiological studies have suggested that certain paternal occupations may be associated with an increased prevalence of birth defects in offspring. Using data from the National Birth Defects Prevention Study, the authors investigated the association between paternal occupation

  20. Paternal occupation and birth defects: findings from the National Birth Defects Prevention Study

    OpenAIRE

    Desrosiers, T.A.; Herring, A H; Shapira, S K; Hooiveld, M.; Luben, T.J.; Herdt-Losavio, M.L.; LIN, S.; Olshan, A.F.

    2012-01-01

    Objectives: Several epidemiological studies have suggested that certain paternal occupations may be associated with an increased prevalence of birth defects in offspring. Using data from the National Birth Defects Prevention Study, the authors investigated the association between paternal occupation and birth defects in a case–control study of cases comprising over 60 different types of birth defects (n=9998) and non-malformed controls (n=4066) with dates of delivery between 1997 and 2004. Me...

  1. Department of Defense Birth and Infant Health Registry: Annual Report on Birth Defects Among Infants Born to U.S. Military Families, January 1, 2000 Through December 31, 2000

    Science.gov (United States)

    2005-03-01

    745.4 Ventricular septal defect 745.5 Atrial septal defect 745.6 Endocardial cushion defects 746.01-746.02 Pulmonary valve...left heart syndrome 747.0 Patent ductus arteriosus 747.1 Coarctation of aorta 747.3 Anomalies of pulmonary artery Resp Respiratory...Biliary atresia Male Male Reproductive 752.6 Hypospadias, epispadias Urinary Urinary 753.0 Renal agenesis /dysgenesis 753.2/753.6 Obstructive

  2. Birth defects in children with newborn encephalopathy

    NARCIS (Netherlands)

    Felix, JF; Badawi, N; Kurinczuk, JJ; Bower, C; Keogh, JM; Pemberton, PJ

    2000-01-01

    This study was designed to investigate birth defects found in association with newborn encephalopathy. All possible birth defects were ascertained in a population-based study of 276 term infants with moderate or severe encephalopathy and 564 unmatched term control infants. A strong association betwe

  3. Acardia : Epidemiologic Findings and Literature Review From the International Clearinghouse for Birth Defects Surveillance and Research

    NARCIS (Netherlands)

    Botto, Lorenzo D.; Feldkamp, Marcia L.; Amar, Emmanuelle; Carey, John C.; Castilla, Eduardo E.; Clementi, Maurizio; Cocchi, Guido; de Walle, Hermien E. K.; Halliday, Jane; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Marengo, Lisa K.; Martinez-Frias, Maria-Luisa; Merlob, Paul; Morgan, Margery; Luna Munoz, Leonora; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Mastroiacovo, Pierpaolo

    2011-01-01

    Acardia is a severe, complex malformation of monozygotic twinning, but beyond clinical case series, very few epidemiologic data are available. The goals of this study were to assess the epidemiologic characteristics of acardia from birth defect registries in the International Clearinghouse for Birth

  4. Guidance for Preventing Birth Defects

    Science.gov (United States)

    ... some health problems for the baby, such as low birth weight. It’s never too late to quit smoking. Learn more about smoking during pregnancy » Avoid marijuana and other “street drugs”. A ... a baby who is born preterm, of low birth weight, or has other health problems, such as ...

  5. Associations of birth defects with adult intellectual performance, disability and mortality: population-based cohort study.

    Science.gov (United States)

    Eide, Martha G; Skjaerven, Rolv; Irgens, Lorentz M; Bjerkedal, Tor; Oyen, Nina

    2006-06-01

    Infants born with birth defects have poorer outcomes in terms of mortality and disability, but the long-term intellectual outcome in children with birth defects is generally unknown. We assessed the long-term associations of various birth defects with mortality and disability, and evaluated whether high mortality and disability were reflected in impaired intellectual performance at age 18. In this nationwide cohort study, records of 9,186 males with and 384,384 without birth defects, registered in the Medical Birth Registry of Norway (1967-1979) were linked to the National Conscript Service (1984-1999). Mortality and disability before military draft, and intelligence test score at conscription were the main outcome measures. Males with birth defects had a relative risk for disability of 6.0 compared with males without defects. Disability was low within categories of birth defects associated with low mortality, and high within defect categories associated with high mortality. The relative risk for not being drafted was highest if maternal educational level was low. Heart defects and cleft palate were the only subgroups in which intellectual performance was lower after adjustment for maternal education, maternal age, marital status and birth order. In particular, intellectual performance was not impaired among those with multiple compared with single defects. We conclude that for the majority of birth defect categories in the present birth cohort, our hypothesis that intellectual performance would be impaired was not confirmed. Thus, there seems to be little reason to fear an adverse intellectual outcome in non-disabled surviving infants with birth defects.

  6. Descriptive epidemiology of selected birth defects, areas of Lombardy, Italy, 1999

    Directory of Open Access Journals (Sweden)

    Frassoldi Emanuela

    2007-05-01

    Full Text Available Abstract Background Birth defects are a leading cause of neonatal and infant mortality in Italy, however little is known of the etiology of most defects. Improvements in diagnosis have revealed increasing numbers of clinically insignificant defects, while improvements in treatment have increased the survival of those with more serious and complex defects. For etiological studies, prevention, and management, it is important to have population-based monitoring which provides reliable data on the prevalence at birth of such defects. Methods We recently initiated population-based birth defect monitoring in the Provinces of Mantova, Sondrio and Varese of the Region of Lombardy, northern Italy, and report data for the first year of operation (1999. The registry uses all-electronic source files (hospital discharge files, death certificates, regional health files, and pathology reports and a proven case-generation methodology, which is described. The data were checked manually by consulting clinical records in hospitals. Completeness was checked against birth certificates by capture-recapture. Data on cases were coded according to the four-digit malformation codes of the International Classification of Diseases, Ninth Revision (ICD-9. We present data only on selected defects. Results We found 246 selected birth defects in 12,008 live births in 1999, 148 among boys and 98 among girls. Congenital heart defects (particularly septal defects were the most common (90.8/10,000, followed by defects of the genitourinary tract (34.1/10, 000 (particularly hypospadias in boys, digestive system (23.3/10,000 and central nervous system (14.9/10,000, orofacial clefts (10.8/10,000 and Down syndrome (8.3/10,000. Completeness was satisfactory: analysis of birth certificates resulted in the addition of two birth defect cases to the registry. Conclusion This is the first population-based analysis on selected major birth defects in the Region. The high birth prevalences for

  7. When Your Baby Has a Birth Defect

    Science.gov (United States)

    ... places to get information include: books written for parents of children with birth defects national organizations such as the March of Dimes, the National Information Center for Children and Youth With Disabilities, and those ... groups or other parents Keep a file with a running list of ...

  8. Zika-Linked Birth Defects Surge in Colombia: CDC

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162464.html Zika-Linked Birth Defects Surge in Colombia: CDC Study ... born with devastating birth defects linked to the Zika virus is no longer confined to Brazil, a ...

  9. How Do Health Care Providers Diagnose Birth Defects?

    Science.gov (United States)

    ... main types of prenatal tests for birth defects. Amniocentesis 1 Amniocentesis (pronounced am-nee-oh-sen-TEE-sis ) is ... Some birth defects that can be detected with amniocentesis are Down syndrome and certain types of muscular ...

  10. Generations, reproduction and birth outcome. A registry-based cohort study in Norway 1967-2006

    OpenAIRE

    Nordtveit, Tone Irene

    2010-01-01

    Aims: Our aim was to describe associations between birth outcomes across two generations. Hypotheses were proposed about how genetic and environmental, behavioural and socioeconomic factors may act on reproduction and birth outcomes through generations. Methods. Population-based cohort studies for two generations. Data were derived from the Medical Birth Registry of Norway (MBRN) based on all births in Norway between 1967 and 2006 (Paper I 1967-2004), more than 2.3 million b...

  11. Maternal occupation and the risk of birth defects: an overview from the National Birth Defects Prevention Study.

    NARCIS (Netherlands)

    Herdt-Losavio, M.L.; Lin, S.; Chapman, B.R.; Hooiveld, M.; Olshan, A.; Liu, X.; DePersis, R.D.; Zhu, J.; Druschel, C.M.

    2010-01-01

    OBJECTIVES: To examine the association between a spectrum of 24 maternal occupations and 45 birth defects for hypothesis generating purposes. METHODS: Cases of isolated and multiple birth defects (n = 8977) and all non-malformed live-born control births (n = 3833) included in the National Birth Defe

  12. Spatiotemporal Property Analysis of Birth Defects in Wuxi, China

    Institute of Scientific and Technical Information of China (English)

    JI-LEI WU; GONG CHEN; XIN-MING SONG; CHENG-FU LI; LEI ZHANG; LAN LIU; XIAO-YING ZHENG

    2008-01-01

    Objective To describe the temporal trends and spatial patterns of birth defects occurring in Wuxi, a developed region of China. Methods Wavelet analysis was used to decompose the temporal trends of birth defect prevalence based on the birth defect rates over the past 16 years. Birth defect cases with detailed personal and family information were geo-coded and the relative risk in each village was calculated. General G statistic was used to test the spatial property with different scales. Results Wavelet analysis showed an increasing temporal trend of birth defects in this region. Clustering analysis revealed that changes continued in the spatial patterns with different scales. Conclusion Wuxi is confronted with severe challenges to reduce birth defect prevalence. The risk factors are stable and show no change with spatial scale but an increasing temporal trend. Interventions should be focused on villages with a higher prevalence of birth defects.

  13. Defining smallness for gestational age in the early years of the Danish Medical Birth Registry

    DEFF Research Database (Denmark)

    á Rogvi, Rasmus; Mathiasen, Rene; Greisen, Gorm

    2011-01-01

    Being born small for gestational age (SGA) is associated with decreased insulin sensitivity and increased blood pressure in childhood, but the association with clinical disease in early adulthood is less certain. The Danish Medical Birth Registry has registered all births in Denmark since 1973...

  14. Laterality defects in the national birth defects prevention study 1998-2007 birth prevalence and descriptive epidemiology

    Science.gov (United States)

    Little is known epidemiologically about laterality defects. Using data from the National Birth Defects Prevention Study (NBDPS), a large multi-site case-control study of birth defects, we analyzed prevalence and selected characteristics in children born with laterality defects born from 1998 to 2007...

  15. Maternal intake of vitamin E and birth defects, National Birth Defects Prevention Study, 1997–2005

    Science.gov (United States)

    Gilboa, Suzanne M.; Lee, Kyung A.; Cogswell, Mary E.; Traven, Flavia K.; Botto, Lorenzo D.; Riehle-Colarusso, Tiffany; Correa, Adolfo; Boyle, Coleen A.

    2015-01-01

    Background In a recent study, high maternal periconceptional intake of vitamin E was found to be associated with risk of congenital heart defects (CHDs). To explore this association further, we investigated the association between total daily vitamin E intake and selected birth defects. Methods We analyzed data from 4,525 controls and 8,665 cases from the 1997–2005 National Birth Defects Prevention Study. We categorized estimated periconceptional energy-adjusted total daily vitamin E intake from diet and supplements into quartiles (referent, lowest quartile). Associations between quartiles of energy-adjusted vitamin E intake and selected birth defects were adjusted for demographic, lifestyle, and nutritional factors. Results We observed a statistically significant association with the third quartile of vitamin E intake (OR 1.17; 95% CI 1.01 – 1.35) and all CHDs combined. Among CHD sub-types, we observed associations with left ventricular outflow tract obstruction defects, and its sub-type, coarctation of the aorta and the third quartile of vitamin E intake. Among defects other than CHDs, we observed associations between anorectal atresia and the third quartile of vitamin E intake (OR 1.66; 95% CI 1.01 – 2.72) and hypospadias and the fourth quartile of vitamin E intake (OR 1.42; 95% CI 1.09 – 1.87). Conclusions Selected quartiles of energy-adjusted estimated total daily vitamin E intake were associated with selected birth defects. However, because these few associations did not exhibit exposure-response patterns consistent with increasing risk associated with increasing intake of vitamin E, further studies are warranted to corroborate our findings. PMID:24740457

  16. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1994-05-01

    The US DOE funded this grant to the Medical University of South Carolina for a cancer and birth defects registry for an initial three year period which was completed as of April 29, 1994. While this Technical Progress Report is prepared principally to document the activities of year 03, it also summarizes the accomplishments of the first two years in order to put into perspective the energy and progress of the program over the entire three year funding cycle.

  17. Preventing birth defects: The value of the NBDPS case-control approach.

    Science.gov (United States)

    Dolk, Helen

    2015-08-01

    Birth Defect Registries provide a basis for epidemiological research into risk factors, thus facilitating a growing understanding of what causes congenital anomalies and how one might target preventive public health actions and reduce inequalities. The National Birth Defects Prevention Study (NBDPS) has used 10 U.S. registries as a basis for a large case-control study. This commentary reviews its methodology and selected areas of output. The strengths of NBDPS lie in the quality of diagnostic coding and classification of birth defects and its size. The sources of bias in NBDPS data relate particularly to retrospective exposure ascertainment entailing a long period of recall, incomplete ascertainment of terminations of pregnancy for fetal anomaly, and unknown bias in case selection. NBDPS results have shown the protective effect of healthy dietary patterns, but have not been as informative as expected in relation to furthering understanding of the protective effect of folic acid. NBDPS medication studies are making important contributions to addressing the gap in existing evidence systematically across a wide range of birth defects, but are challenged by the quality of information on exposure, dose and underlying disease condition, and the interpretation of results of multiple testing. Studies of environmental contaminants in collaboration with experts in exposure assessment have linked addresses to residential exposure measures, using the advantages of information on residential history and confounders, but are challenged by the need to consider exposure mixtures. NBDPS could increase its public health impact by placing more emphasis on socioeconomic inequalities.

  18. Beating Birth Defects (A Cup of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2013-01-17

    Each year in the U.S., one in 33 babies is affected by a major birth defect. Women can greatly improve their chances of giving birth to a healthy baby by avoiding some of the risk factors for birth defects before and during pregnancy. In this podcast, Dr. Stuart Shapira discusses ways to improve the chances of giving birth to a healthy baby.  Created: 1/17/2013 by MMWR.   Date Released: 1/17/2013.

  19. Cancer and birth defects surveillance system for communities around the Savannah River Site: Phase 2 -- Birth defects. Technical progress report, year 01

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1995-10-01

    The Savannah River Region Health Information System Birth Defects Registry (SRRHIS-BDR) began on September 30, 1994. As with the SRRHIS Cancer Registry, surveillance of the 12 Georgia counties was subcontracted to Emory University School of Public Health. Collaborative efforts between the Medical University of South Carolina (MUSC) and Emory University staffs have been characterized by warm relationships and commitment to developing a state of the art registry. As a result of early planning efforts, the authors were able to actually activate the data collection. As of the end of September 1995, partial data from the 1994 birth cohort and up-to-date data for the 1995 birth cohort had been collected on the South Carolina side. The Georgia Staff started later and have not yet caught up to the 1994 level. South Carolina was able to start earlier because they were fortunate to quickly recruit an abstractor. Also, by the end of the first year, an innovative automated data entry system for laptop computers was developed by the computer staff to facilitate and improve data collection.

  20. Systems Biology and Birth Defects Prevention: Blockade of the Glucocorticoid Receptor Prevents Arsenic-Induced Birth Defects

    OpenAIRE

    Ahir, Bhavesh K.; Sanders, Alison P.; Julia E. Rager; Fry, Rebecca C.

    2013-01-01

    Background: The biological mechanisms by which environmental metals are associated with birth defects are largely unknown. Systems biology–based approaches may help to identify key pathways that mediate metal-induced birth defects as well as potential targets for prevention. Objectives: First, we applied a novel computational approach to identify a prioritized biological pathway that associates metals with birth defects. Second, in a laboratory setting, we sought to determine whether inhibiti...

  1. National Birth Defects Prevention Study (NBDPS)

    Science.gov (United States)

    ... Heart Defects Atrial Septal Defect Atrioventricular Septal Defect Coarctation of the Aorta D-Transposition of the Great ... Defects Fetal Alcohol Syndrome Disorders Gastroschisis Heart Defects Coarctation of the Aorta Hypoplastic left heart syndrome Tetralogy ...

  2. Neural tube defects in Costa Rica, 1987-2012: origins and development of birth defect surveillance and folic acid fortification.

    Science.gov (United States)

    Barboza-Argüello, María de la Paz; Umaña-Solís, Lila M; Azofeifa, Alejandro; Valencia, Diana; Flores, Alina L; Rodríguez-Aguilar, Sara; Alfaro-Calvo, Thelma; Mulinare, Joseph

    2015-03-01

    Our aim was to provide a descriptive overview of how the birth defects surveillance and folic acid fortification programs were implemented in Costa Rica-through the establishment of the Registry Center for Congenital Anomalies (Centro de Registro de Enfermedades Congénitas-CREC), and fortification legislation mandates. We estimated the overall prevalence of neural tube defects (i.e., spina bifida, anencephaly and encephalocele) before and after fortification captured by CREC. Prevalence was calculated by dividing the total number of infants born with neural tube defects by the total number of live births in the country (1987-2012).A total of 1,170 newborns with neural tube defects were identified from 1987 to 2012 (1992-1995 data excluded); 628 were identified during the baseline pre-fortification period (1987-1991; 1996-1998); 191 during the fortification period (1999-2002); and 351 during the post-fortification time period (2003-2012). The overall prevalence of neural tube defects decreased from 9.8 per 10,000 live-births (95 % CI 9.1-10.5) for the pre-fortification period to 4.8 per 10,000 live births (95 % CI 4.3-5.3) for the post-fortification period. Results indicate a statistically significant (P neural tube defects from the pre-fortification period to the post-fortification period. Folic acid fortification via several basic food sources has shown to be a successful public health intervention for Costa Rica. Costa Rica's experience can serve as an example for other countries seeking to develop and strengthen both their birth defects surveillance and fortification programs.

  3. A Prescription for the Prevention of Birth Defects.

    Science.gov (United States)

    Slavkin, Harold C.

    1984-01-01

    Factors influencing birth defects include maternal age (teenagers and women over 32 are at risk), genetics, drug use, diet habits, and environmental hazards. The physical, social, and economic costs of birth defects are extreme. Prevention must involve efforts to change some of these factors. (Author/CS)

  4. New Guidelines Reaffirm Prenatal Folic Acid to Curb Birth Defects

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_162970.html New Guidelines Reaffirm Prenatal Folic Acid to Curb Birth Defects ... HealthDay News) -- In a recommendation that reaffirms previous guidelines, the U.S. Preventive Services Task Force said that ...

  5. Birth Defects from Zika More Far-Reaching Than Thought

    Science.gov (United States)

    ... gov/news/fullstory_162538.html Birth Defects From Zika More Far-Reaching Than Thought Studies found greater ... 14, 2016 WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- Zika's ability to damage the infant brain may be ...

  6. Geocoding capacity of birth defects surveillance programs: results from the National Birth Defects Prevention Network Geocoding Survey.

    Science.gov (United States)

    Wang, Ying; O'Leary, Leslie A; Rickard, Russel S; Mason, Craig A

    2010-01-01

    A Web-based survey focusing on geocoding of birth defects data was developed and administrated to gain an understanding of the capacity of state birth defects programs to geocode maternal residence and to identify barriers to geocoding birth defects data. The survey consisted of 21 questions related to geocoding of maternal residence, type of software used, barriers to geocoding, and data linkage. In August 2007, an e-mail with a Web link to the survey was sent to all state birth defects program contacts in the United States, including the District of Columbia, Puerto Rico, and the Centers for Disease Control and Prevention (CDC) requesting they complete the online survey. By October 2007, 39 (74%) out of 53 birth defects program contacts completed the survey. Although nearly all birth defects programs collect maternal residential data, many are not currently geocoding that data. Results indicated that 97% of the programs that completed the survey reported they collected data on maternal residence, 53% of which reported that the birth defects surveillance data were geocoded to the street address level using maternal residential address at delivery. Twenty six percent of the programs that do not currently geocode the data identified "Software and address reference file are not available" as the most significant barrier to geocoding; another 16% chose "Lack of funding" as the most significant barrier to geocoding. Since geocoding is an important component of spatial analyses used to detect potential clusters of birth defects, leveraging resources to overcome the barriers that prevent programs from geocoding is important.

  7. The Survey of Birth Defects Rate Based on Birth Registration System

    Directory of Open Access Journals (Sweden)

    Min Yu

    2015-01-01

    Conclusions: A downward trend of birth defects was observed in Xi′an City from 2003 to 2012. NTDs significantly decreased after large-scale supplemental folic acid intervention, while the incidence rate of CHD significantly increased.

  8. Birth order and neural tube defects: a reappraisal.

    Science.gov (United States)

    Vieira, Alexandre R

    2004-01-15

    There is evidence that late birth order is associated with some complex disorders. For neural tube defects (NTDs) there is no consensus as to whether first or increased birth order is associated or not. A meta-analysis of published data on NTDs was carried out to ascertain whether there is an increased risk for children first born or of high birth order to have NTDs. All data available with information regarding the frequency of live births and NTDs cases by birth order (1, 2, 3, and 4 or more) were included in the analysis. Effect sizes calculations were performed. Children with higher birth order are more likely to have spina bifida but not anencephaly. This same effect was also seen for all NTDs combined, which probably reflects the association with spina bifida. These results suggest the compilation of anencephaly and spina bifida data can be the explanation for the controversies seen in the literature.

  9. Birth defects in India: Hidden truth, need for urgent attention

    Directory of Open Access Journals (Sweden)

    Rinku Sharma

    2013-01-01

    Indian people are living in the midst of risk factors for birth defects, e.g., universality of marriage, high fertility, large number of unplanned pregnancies, poor coverage of antenatal care, poor maternal nutritional status, high consanguineous marriages rate, and high carrier rate for hemoglobinopathies. India being the second most populous country with a large number infant born annually with birth defects should focus its attention on strategies for control of birth defects. Many population based strategies such as iodization, double fortification of salt, flour fortification with multivitamins, folic acid supplementation, periconceptional care, carrier screening and prenatal screening are some of proven strategies for control of birth defects. Strategies such as iodization of salt in spite of being initiated for a long time in the past do have a very little impact on its consumption (only 50% were using iodized salt. Community genetic services for control of birth defects can be easily flourished and integrated with primary health care in India because of its well established infrastructure and personnel in the field of maternal and child health care. As there is wide variation for infant mortality rate (IMR in different states in India, so there is a need of deferential approach to implement community genetic services in states those had already achieved national goal of IMR. On the other hand, states those have not achieved the national goal on IMR priority should be given to management of other causes of infant mortality.

  10. The Association Between Reported Venlafaxine Use in Early Pregnancy and Birth Defects, National Birth Defects Prevention Study, 1997–2007

    Science.gov (United States)

    Polen, Kara ND; Rasmussen, Sonja A; Riehle-Colarusso, Tiffany; Reefhuis, Jennita

    2015-01-01

    Background Few epidemiologic studies have investigated the use of venlafaxine (Effexor®), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine during pregnancy is associated with specific birth defects. Methods We used data from the National Birth Defects Prevention Study (NBDPS), a population-based, case-control study in the United States. Our analysis included mothers with pregnancies affected by one of 30 selected birth defects (cases) and babies without birth defects (controls) with estimated dates of delivery between 1997–2007. Exposure was any reported use of venlafaxine from one month preconception through the third month of pregnancy. We calculated adjusted odds ratios (aORs) and 95% Fisher’s Exact confidence intervals (CIs) for 24 birth defect groups for which at least 400 case mothers were interviewed. Our adjusted analyses controlled for maternal age and race-ethnicity. Results Among the 27,045 NBDPS participants who met inclusion criteria, 0.17% (14/8,002) of control mothers and 0.40% (77/19,043) of case mothers reported any use of venlafaxine from one month preconception through the third month of pregnancy. Statistically significant associations were found for anencephaly, atrial septal defect (ASD) secundum or ASD not otherwise specified, coarctation of the aorta, cleft palate, and gastroschisis. Conclusions Our data suggest associations between periconceptional use of venlafaxine and some birth defects. However, sample sizes were small, confidence intervals were wide, and additional studies are needed to confirm these results. PMID:23281074

  11. Baseline Prevalence of Birth Defects Associated with Congenital Zika Virus Infection - Massachusetts, North Carolina, and Atlanta, Georgia, 2013-2014.

    Science.gov (United States)

    Cragan, Janet D; Mai, Cara T; Petersen, Emily E; Liberman, Rebecca F; Forestieri, Nina E; Stevens, Alissa C; Delaney, Augustina; Dawson, April L; Ellington, Sascha R; Shapiro-Mendoza, Carrie K; Dunn, Julie E; Higgins, Cathleen A; Meyer, Robert E; Williams, Tonya; Polen, Kara N D; Newsome, Kim; Reynolds, Megan; Isenburg, Jennifer; Gilboa, Suzanne M; Meaney-Delman, Dana M; Moore, Cynthia A; Boyle, Coleen A; Honein, Margaret A

    2017-03-03

    Zika virus infection during pregnancy can cause serious brain abnormalities, but the full range of adverse outcomes is unknown (1). To better understand the impact of birth defects resulting from Zika virus infection, the CDC surveillance case definition established in 2016 for birth defects potentially related to Zika virus infection* (2) was retrospectively applied to population-based birth defects surveillance data collected during 2013-2014 in three areas before the introduction of Zika virus (the pre-Zika years) into the World Health Organization's Region of the Americas (Americas) (3). These data, from Massachusetts (2013), North Carolina (2013), and Atlanta, Georgia (2013-2014), included 747 infants and fetuses with one or more of the birth defects meeting the case definition (pre-Zika prevalence = 2.86 per 1,000 live births). Brain abnormalities or microcephaly were the most frequently recorded (1.50 per 1,000), followed by neural tube defects and other early brain malformations(†) (0.88), eye abnormalities without mention of a brain abnormality (0.31), and other consequences of central nervous system (CNS) dysfunction without mention of brain or eye abnormalities (0.17). During January 15-September 22, 2016, the U.S. Zika Pregnancy Registry (USZPR) reported 26 infants and fetuses with these same defects among 442 completed pregnancies (58.8 per 1,000) born to mothers with laboratory evidence of possible Zika virus infection during pregnancy (2). Although the ascertainment methods differed, this finding was approximately 20 times higher than the proportion of one or more of the same birth defects among pregnancies during the pre-Zika years. These data demonstrate the importance of population-based surveillance for interpreting data about birth defects potentially related to Zika virus infection.

  12. Evaluating alcohol related birth defects in the past

    DEFF Research Database (Denmark)

    Shuler, Kristrina A.; Schroeder, Hannes

    2013-01-01

    Alcohol Related Birth Defects (ARBD) are yet undocumented among past communities, although alcohol is the leading cause of non-heritable birth defects in the US today. We evaluate potential ARBD at Newton Plantation, Barbados (ca. 1660-1820), where earlier studies suggest frequent, community......-wide consumption of lead-tainted rum by enslaved Africans. Skeletons excavated in 1997-1998 (n= 45) were examined for congenital anomalies, using clinical/experimental descriptions to differentially diagnose possible ARBD. Enamel lead data served as a proxy for developmental exposure to tainted rum in a subsample...

  13. Laterality Defects in the National Birth Defects Prevention Study (1998–2007): Birth Prevalence and Descriptive Epidemiology

    Science.gov (United States)

    Lin, Angela E.; Krikov, Sergey; Riehle-Colarusso, Tiffany; Frías, Jaime L.; Belmont, John; Anderka, Marlene; Geva, Tal; Getz, Kelly D.; Botto, Lorenzo D.

    2015-01-01

    Little is known epidemiologically about laterality defects. Using data from the National Birth Defects Prevention Study (NBDPS), a large multi-site case-control study of birth defects, we analyzed prevalence and selected characteristics in children born with laterality defects born from 1998 to 2007. We identified 517 nonsyndromic cases (378 heterotaxy, 73.1%; 139 situs inversus totalis [SIT], 26.9%) resulting in an estimated birth prevalence of 1.1 per 10,000 live births (95% confidence interval 1.0–1.2). Prevalence did not differ significantly across sites, over time, or by inclusion of pregnancy termination. Laterality defects were more common among preterm cases compared to term cases, and in children born to mothers who were non-white or younger than 20 years compared to white mothers or those age 25–29 years. The distribution of associated cardiac and extracardiac defects, excluding the expected heterotaxy anomalies, varied by type of laterality defect. Cases with heterotaxy were significantly more likely than those with SIT to have double outlet right ventricle, atrioventricular canal defects, pulmonary stenosis, non-tetralogy of Fallot pulmonary atresia with ventricular septal defect, totally and partially anomalous pulmonary venous return; also more likely to have orofacial clefts, esophageal atresia, bowel atresias, and omphalocele, though not reaching statistical significance. Relatively more common among cases with SIT were Dandy-Walker malformation, anotia/microtia, and limb deficiency. The similarity in the demographic characteristics of heterotaxy and SIT supports the hypothesis that they are part of a continuum of abnormal left-right axis patterning. These findings on laterality defects may help guide clinical care, future research, and prevention strategies. PMID:25099286

  14. Are omphalocele and neural tube defects related congenital anomalies? : Data from 21 registries in Europe (EUROCAT)

    NARCIS (Netherlands)

    Calzolari, E; Dolk, H; Stone, D; Milan, M

    1997-01-01

    We have analyzed the association between omphalocele and neural tube defects (O/NTD) previously reported in epidemiological studies of EUROCAT registry data [DoIk et al., 1991; Calzolari et al., 1995]. By examining differences in prevalence between the United Kingdom and Ireland (UKI) and Continenta

  15. Antihistamines and Birth Defects: A Systematic Review of the Literature

    Science.gov (United States)

    Gilboa, Suzanne M.; Ailes, Elizabeth C.; Rai, Ramona P.; Anderson, Jaynia A.; Honein, Margaret A.

    2015-01-01

    Introduction Approximately 10-15% of women reportedly take an antihistamine during pregnancy for the relief of nausea and vomiting, allergy and asthma symptoms, or indigestion. Antihistamines include histamine H1-receptor and H2-receptor antagonists. Areas covered This is a systematic evaluation of the peer-reviewed epidemiologic literature published through February 2014 on the association between prenatal exposure to antihistamines and birth defects. Papers addressing histamine H1- or H2-receptor antagonists are included. Papers addressing pyridoxine plus doxylamine (Bendectin in the United States, Debendox in the United Kingdom, Diclectin in Canada, Lenotan and Merbental in other countries) prior to the year 2001 were excluded post-hoc because of several previously published meta-analyses and commentaries on this medication. Expert opinion The literature on the safety of antihistamine use during pregnancy with respect to birth defects is generally reassuring though the positive findings from a few large studies warrant corroboration in other populations. The findings in the literature are considered in light of three critical methodological issues: (1) selection of appropriate study population; (2) ascertainment of antihistamine exposures; and (3) ascertainment of birth defects outcomes. Selected antihistamines have been very well-studied (e.g. loratadine); others, especially H2- receptor antagonists, require additional study before an assessment of safety with respect to birth defects risk could be made. PMID:25307228

  16. International retrospective cohort study of neural tube defects in relation to folic acid recommendations : are the recommendations working?

    NARCIS (Netherlands)

    Botto, LD; Lisi, A; Robert-Gnansia, E; Erickson, JD; Vollset, SE; Mastroiacovo, P; Botting, B; Cocchi, G; de Vigan, C; de Walle, H; Feijoo, M; Irgens, LM; McDonnell, B; Merlob, P; Ritvanen, A; Scarano, G; Siffel, C; Metneki, J; Stoll, C; Smithells, R; Goujard, J

    2005-01-01

    Objective To evaluate the effectiveness of policies and recommendations on folic acid aimed at reducing the occurrence of neural tube defects. Design Retrospective cohort study of births monitored by birth defect registries. Setting 13 birth defects registries monitoring rates of neural tube defects

  17. Parental mental illness and fatal birth defects in a national birth cohort

    DEFF Research Database (Denmark)

    Webb, Roger; Pickles, A.R.; King-Hele, Sarah

    2007-01-01

    BACKGROUND: Few large studies describe links between maternal mental illness and risk of major birth defect in offspring. Evidence is sparser still for how effects vary between maternal diagnoses and no previous study has assessed risk with paternal illnesses.MethodA population-based birth cohort...... genetic effects directly linked with maternal illness, lifestyle factors (diet, smoking, alcohol and drugs), poor antenatal care, psychotropic medication toxicity, and gene-environment interactions. Further research is needed to elucidate the causal mechanisms......BACKGROUND: Few large studies describe links between maternal mental illness and risk of major birth defect in offspring. Evidence is sparser still for how effects vary between maternal diagnoses and no previous study has assessed risk with paternal illnesses.MethodA population-based birth cohort...... was created by linking Danish national registers. We identified all singleton live births during 1973-1998 (n=1.45 m), all parental psychiatric admissions from 1969 onwards, and all fatal birth defects until 1 January 1999. Linkage and case ascertainment were almost complete. Relative risks were estimated...

  18. Genetic basis of susceptibility to teratogen induced birth defects.

    Science.gov (United States)

    Wlodarczyk, Bogdan J; Palacios, Ana M; Chapa, Claudia J; Zhu, Huiping; George, Timothy M; Finnell, Richard H

    2011-08-15

    Birth defects remain the leading cause of infant death in US. The field of teratology has been focused on the causes and underlying mechanisms of birth defects for decades, yet our understanding of these critical issues remain unacceptably vague. Conclusions from years of animal and human studies made it clear that the vast majority of birth defects have multifactorial origins, with contributions from environmental and genetic factors. The environment comprises not only of the physical, biological, and chemical external environment surrounding the pregnant woman, but it also includes the internal environment of the woman's body that interact with the developing embryo in a complex fashion. The importance of maternal and embryonic genetic factors consisting of countless genetic variants/mutations that exist within every individual contribute to birth defect susceptibility is only now being more fully appreciated. This great complexity of the genome and its diversity within individuals and populations seems to be the principal reason why the same teratogenic exposure can induce severe malformation in one embryo, while fail to do so to other exposed embryos. As the interaction between genetic and environmental factors has long been recognized as the first "Principle of Teratology" by Wilson and Warkany [1965. Teratology: Principles and techniques. Chicago: University of Chicago Press], it is only recently that the appropriate investigative tools have been developed with which to fully investigate this fundamental principle. The introduction of high throughput technologies like whole genome sequencing or genome-wide association studies are promising to deliver an enormous amount of new data that will shed light on the genomic factors that contribute susceptibility to environmental teratogens. In this review, we attempt to summarize the epidemiological and experimental literature concerning birth defects whose phenotypic expression can be clearly related to the

  19. The Survey of Birth Defects Rate Based on Birth Registration System

    Institute of Scientific and Technical Information of China (English)

    Min Yu; Zhiguang Ping; Shuiping Zhang; Yuying He; Rui Dong; Xiong Guo

    2015-01-01

    Background:To investigate the surveillance trend of birth defects,incidence,distribution,occurrence regularity,and their relevant factors in Xi'an City in the last 10 years for proposing control measures.Methods:The birth defects monitoring data of infants during perinatal period (28 weeks of gestation to 7 days after birth) were collected from obstetrics departments of all hospitals during 2003-2012.Microsoft Excel 2003 was used for data input,and Statistical Package for the Social Sciences version 16.0 (International Business Machines Corporation,New York,NY,USA) was used for descriptive analysis.x2 test,Spearman correlation and linear-by-linear association trend test were used for statistical analyses.Results:The birth defect rate declined from 9.18% in 2003 to 7.00% in 2012 (x2 =45.00 l,P < 0.01) with a mean value of 7.85%,which is below the Chinese national average level (x2 =20.451,P < 0.01).The order of five most common birth defects has changed.The incidence of congenital heart disease (CHD) increased with time,particularly after 2012,it became the most frequent type (rs =0.808,P < 0.001).Till then,the number of neural tube defects (NTDs) declined significantly (x2 =76.254,P < 0.01).The average birth defects rate of 8.11% in rural areas was higher than that in urban areas (7.56%,x2 =7.919,P < 0.01) and much higher in males (8.28%) than that in females (7.18%,x2 =32.397,P < 0.0 1).Maternal age older than 35 years (x2 =35.298,P < 0.01) is the most dangerous age bracket of birth defects than maternal age younger than 20 years (x2 =7.128,P < 0.0l).Conclusions:A downward trend of birth defects was observed in Xi'an City from 2003 to 2012.NTDs significantly decreased after large-scale supplemental folic acid intervention,while the incidence rate of CHD significantly increased.

  20. Birth defects in pregestational diabetes: Defect range,glycemic threshold and pathogenesis

    Institute of Scientific and Technical Information of China (English)

    Rinat Gabbay-Benziv; E Albert Reece; Fang Wang, Peixin Yang

    2015-01-01

    Currently, 60 million women of reproductive age(18-44 years old) worldwide, and approximately 3million American women have diabetes mellitus, andit has been estimated that this number will doubleby 2030. Pregestational diabetes mellitus (PGD) is asignificant public health problem that increases therisk for structural birth defects affecting both maternaland neonatal pregnancy outcome. The most commontypes of human structural birth defects associated withPGD are congenital heart defects and central nervoussystem defects. However, diabetes can induce birthdefects in any other fetal organ. In general, the rateof birth defects increases linearly with the degree ofmaternal hyperglycemia, which is the major factor thatmediates teratogenicity of PGD. Stringent prenatal careand glycemic control are effective means to reducebirth defects in PGD pregnancies, but cannot reducethe incidence of birth defects to the rate of that is seenin the nondiabetic population. Studies in animal modelshave revealed that PGD induces oxidative stress,which activates cellular stress signalling leading todysregulation of gene expression and excess apoptosisin the target organs, including the neural tube andembryonic heart. Activation of the apoptosis signalregulatingkinase 1 (ASK1)-forkhead transcription factor3a (FoxO3a)-caspase 8 pathway causes apoptosis in thedeveloping neural tube leading to neural tube defects(NTDs). ASK1 activates the c-Jun-N-Terminal kinase1/2 (JNK1/2), which leads to activation of the unfoldedprotein response and endoplasmic reticulum (ER) stress.Deletion of the ASK1 gene, the JNK1 gene, or the JNK2gene, or inhibition of ER stress by 4-Phenylbutyric acidabrogates diabetes-induced apoptosis and reduces theformation of NTDs. Antioxidants, such as thioredoxin,which inhibits the ASK1-FoxO3a-caspase 8 pathway orER stress inhibitors, may prevent PGD-induced birthdefects. Gabbay-Benziv R et al . Birth defects in pregestational diabetes

  1. Birth defects monitoring in underdeveloped countries: an example from Uruguay.

    Science.gov (United States)

    Castilla, E E; Lopez-Camelo, J S; Dutra, G P; Paz, J E

    1991-01-01

    Medical authorities in developing countries are primarily interested in nutritional and infectious diseases. Therefore, activities directed to the prevention and control of low priority illnesses, such as birth defects, need to be particularly effective, simple, and economical. Monitoring of congenital anomalies is one of the preventive activities which can be efficiently performed at very low cost. Guidelines for this are given, and their application exemplified by the case of Uruguay. Uruguay has recently attained an infant mortality rate of 20/1,000, with the congenital anomalies ranking as its second cause. The government of Uruguay, through the Pan American Health Organisation/World Health Organisation (PARO/WHO) called the Estudio Colaborativo Latino Americano de Malformaciones Congenitas (ECLAMC) for advice in order to plan a program for the prevention of birth defects. The recommendations given were based on conclusions drawn from the analysis of data the ECLAMC program has been accumulating, from Uruguay and other Latin-American countries, since 1967. The case of Uruguay clearly indicates that sensible guidelines for birth defects prevention can be provided, after working with this "low priority and uninteresting" group of illnesses for more than twenty years.

  2. Primary prevention of neural tube defects: data from the portuguese national registry of congenital anomalies (RENAC)

    OpenAIRE

    Braz, Paula; Machado, Ausenda; Matias Dias, Carlos

    2016-01-01

    Background: In Portugal folic acid supplementation is recommended to start at least 2-3 months before conception for primary prevention of Neural Tube Defects. The aim of this study was to evaluate, within gestations with at least one congenital anomaly, possible association between maternal socio-demographic factors and the use of folic acid. Methods: Using data from the Portuguese national registry of congenital anomalies, for the 2004-2013 period, the association between folic acid use dur...

  3. Development of web-based geocoding applications for the population-based Birth Defects Surveillance System in New York state.

    Science.gov (United States)

    Wang, Ying; Le, Linh H; Wang, Xiaohang; Tao, Zhen; Druschel, Charlotte D; Cross, Philip K; Hwang, Syni-An

    2010-01-01

    Geographic information systems (GIS) have been widely used in mapping health data and analyzing the geographic distribution of disease. Mapping and spatially analyzing data normally begins with geocoding, a process of assigning geographic coordinates to an address so that it can be displayed and analyzed on a map. The objectives of this project were to develop Web-based geocoding applications for the New York State birth defects surveillance system to geocode, both automatically and interactively, the birth defect cases of the Congenital Malformations Registry (CMR) and evaluate the geocoding results. Geocoding software, in conjunction with a Java-based development tool (J Server), was used to develop the Web-based applications on the New York State Department of Health's Health Commerce System. The Web-based geocoding applications have been developed and implemented for the New York State birth defects surveillance system. These menu-driven applications empower users to conduct geocoding activities using only a PC and a Web browser without the installation of any GIS software. These powerful tools provide automatic, real-time, street-level geocoding of the routinely collected birth defects records in the CMR. Up to 92% of the CMR records have been geocoded with addresses exactly matched to the reference addresses on house number, street name, and city or zip code.

  4. Traffic jam in the primitive streak: the role of defective mesoderm migration in birth defects.

    Science.gov (United States)

    Herion, Nils J; Salbaum, J Michael; Kappen, Claudia

    2014-08-01

    Gastrulation is the process in which the three germ layers are formed that contribute to the formation of all major tissues in the developing embryo. We here review mouse genetic models in which defective gastrulation leads to mesoderm insufficiencies in the embryo. Depending on severity of the abnormalities, the outcomes range from incompatible with embryonic survival to structural birth defects, such as heart defects, spina bifida, or caudal dysgenesis. The combined evidence from the mutant models supports the notion that these congenital anomalies can originate from perturbations of mesoderm specification, epithelial-mesenchymal transition, and mesodermal cell migration. Knowledge about the molecular pathways involved may help to improve strategies for the prevention of major structural birth defects.

  5. Maternal Residential Exposure to Agricultural Pesticides and Birth Defects in a 2003 to 2005 North Carolina Birth Cohort

    Science.gov (United States)

    Birth defects are responsible for a large proportion of disability and infant mortality. Exposure to a variety of pesticides have been linked to increased risk of birth defects. We conducted a case-control study to estimate the associations between a residence-based metric of agr...

  6. The primary prevention of birth defects: Multivitamins or folic acid?

    Directory of Open Access Journals (Sweden)

    2004-03-01

    Full Text Available Periconceptional use of folic acid alone or in multivitamin supplements is effective for the primary prevention of neural-tube defects. The Hungarian randomized and two-cohort controlled trials showed that periconceptional multivitamin supplementation can reduce the occurrence of some other structural birth defects, i.e. congenital abnormalities. These findings were supported by many, but not all observational studies. Recently there have been two main debated questions. The first one is whether the use of folic acid alone or folic acid-containing multivitamins is better. The second one is connected with the dilemma of whether high dose of folic acid (e.g. 5 mg might be better than a daily multivitamin with 0.4 – 0.8 mg of folic acid. Comparison of the pooled data of two Hungarian trials using a multivitamin containing 0.8 mg folic acid and the data of the Hungarian Case-Control Surveillance of Congenital Abnormalities using high dose of folic acid seemed to be appropriate to answer these questions. Multivitamins containing 0.4 – 0.8 mg of folic acid were more effective for the reduction of neural-tube defects than high dose of folic acid. Both multivitamins and folic acid can prevent some part of congenital cardiovascular malformations. Only multivitamins were able to reduce the prevalence at birth of obstructive defects of urinary tract, limb deficiencies and congenital pyloric stenosis. However, folic acid was effective in preventing some part of rectal/anal stenosis/atresia, and high dose of folic acid had effect in preventing some orofacial clefts. The findings are consistent that periconceptional multivitamin and folic acid supplementation reduce the overall occurrence of congenital abnormalities in addition to the demonstrated effect on neural-tube defects.

  7. Folic acid supplementation influences the distribution of neural tube defect subtypes : A registry-based study

    NARCIS (Netherlands)

    Bergman, J. E. H.; Otten, E.; Verheij, J. B. G. M.; de Walle, H. E. K.

    2016-01-01

    Periconceptional folic acid (FA) reduces neural tube defect (NTD) risk, but seems to have a varying effect per NTD subtype. We aimed to study the effect of FA supplementation on NTD subtype distribution using data from EUROCAT Northern Netherlands. We included all birth types with non-syndromal NTDs

  8. Application Research of "3+1" Mode for Birth Defects Monitoring

    Institute of Scientific and Technical Information of China (English)

    Hong LIU; Cheng-liang XIONG

    2008-01-01

    Objective To explore the "3+1" monitoring mode for birth defects and quality control measures based on the population,and to obtain the related information data for birth defects.Methods With the community population as the basis,adopting the unified monitoring scheme dominant by the leadership and administration of government,with districts(counties)as the monitoring sites,the "3+1" monitoring mode for birth defects was based on a complete monitoring team with the combination of villages/residents'committees,townships(towns),counties(districts)and the municipality.Demonstration research was carried out in the pilot districts/counties in Chongqing City.Results Birth defects population monitoring system based on population and family planning management and service network was established,and during 2005 and 2006,application research was carried out for the monitoring methods among birth deflects population in the pilot districts(counties),obtaining the relevant information in regional birth defects,with a monitoring coverage of over 99%.Conclusion Fully utilizing the birth management functions of Population and Family Planning System and the advantages of service networks,long term,dynamic birth defects monitoring system based on community population was established,with the integration of birth defects monitoring and regular reproductive health services,obtaining overall birth defects occurrence information in details,providing scientific basis for the government to formulate scientific,practical,economic and effective birth defects intervention policy,so as to improve the quality of the population.

  9. Interaction between epidemiology and laboratory sciences in the study of birth defects: Design of birth defects risk factor surveillance in metropolitan Atlanta

    Energy Technology Data Exchange (ETDEWEB)

    Lynberg, M.C.; Khoury, M.J. (Dept. of Health and Human Services, Atlanta, GA (United States))

    1993-01-01

    Despite years of research, the etiology of most birth defects remains largely unknown. Interview instruments have been the major tools in the search for environmental causes of birth defects. Because of respondents' problems with recognition and recall, interviews are limited in their capacity to measure certain exposures. Laboratory scientists can have a major impact on defining markers of environmental exposure and genetic susceptibility. The Centers for Disease Control is starting a case-control study of serious birth defects on the basis of a population-based surveillance system for birth defects diagnosed during the first year of life in metropolitan Atlanta, Each year, 300 infants with selected birth defects (case subjects) and 100 population-based control subjects (infants without birth defects) will be enrolled in an ongoing study that will supplement surveillance. In addition to conducting extensive maternal interviews, we will collect blood and urine specimens from case and control subjects and their mothers for laboratory testing. Eventually, some environmental sampling may be incorporated. Particular areas of emphasis are (1) nutritional factors, specifically measuring maternal folic acid levels and other micronutrients (e.g., zinc) to explore their role in the etiology of neural tube defects, (2) substance use, specifically measuring cocaine metabolites in the blood and urine to explore their role for specific vascular disruption defects, and (3) environmental factors such as pesticides and aflatoxins, to explore their potential relationships with specific defects. In addition, a DNA bank will be maintained to evaluate the role of specific candidate genes in the etiology of birth defects. The development and testing of these methods could be useful to assess the interaction between environmental exposures and genetic susceptibility in the etiology of birth defects. 15 refs., 1 fig., 1 tab.

  10. Hyperemesis gravidarum in the Medical Birth Registry of Norway – a validity study

    Directory of Open Access Journals (Sweden)

    Vikanes Åse

    2012-10-01

    Full Text Available Abstract Background Valid registration of medical information is essential for the quality of registry-based research. Hyperemesis gravidarum (HG is characterized by severe nausea and vomiting, weight loss and electrolyte imbalance starting before 22nd gestational week. Given the fact that HG is a generally understudied disease which might have short- and long- term health consequences for mother and child, it is of importance to know whether potential misclassification bias influences the results of future studies. We therefore assessed the validity of the HG-registration in the in Medical Birth Registry of Norway (MBRN using hospital records. Methods The sample comprised all women registered in MBRN with HG and who delivered at Ullevål and Akershus hospitals in 1.1.-31.3.1970, 1.4.-30.6.1986, 1.7.-30.9.1997 and 1.10.-31.12.2001. A random sample of 10 women per HG case, without HG according to MBRN, but who delivered during the same time periods at the same hospitals was also collected. The final sample included 551 women. Sensitivity, specificity, positive and negative predictive values (PPV and NPV were estimated using strict and less strict diagnostic criteria of HG, indicating severe and mild HG, respectively. Hospital journals were used as gold standard. Results Using less strict diagnostic criteria of HG, sensitivity, specificity, PPV and NPV were 83.9% (95% CI: 67.4-92.9, 96.0% (95% CI: 93.9-97.3, 55.3% (95% CI: 41.2-68.6 and 99.0% (95% CI: 97.7-99.6, respectively. For strict diagnostic criteria, being hospitalised due to HG the corresponding values were 64% (95% CI: 38.8-87.2, 92% (95% CI: 90.2-94.6, 18.6% (95% CI: 10.2-31.9 and 99.0% (95% CI: 97.7-99.6. Conclusions The results from our study are comparable to previous research on disease registration in MBRN, and show that MBRN can be considered valid for mild HG but not for severe HG.

  11. Folic Acid and Birth Defects: A Case Study (Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Bager Hosseini

    2011-01-01

    Full Text Available The aim of this study was to evaluate the impact of folic acid use in pregnancy for the reduction of neural tube defects (NTDs in the northwest region of Iran. We studied 243 women with pregnancies complicated by some forms of birth defect(s. These patients were identified by medical diagnostic tests as having a fetus with some types of congenital anomalies. The prevalence of NTDs among pregnant women who were referred for therapeutic termination of pregnancy was 24.7 percent. Consumption of folic acid prevented NTDs by 79 percent (Odds Ratio = 0.21, CI 95%: 0.12–0.40 and 94 percent (Odds Ratio = 0.06, CI 95%: 0.03–0.15 compared to pregnancies complicated by other anomalies and normal pregnancies, respectively. Hydrops fetalis, hydrocephaly, Down syndrome, and limb anomalies did not have any significant association with the folic acid use. Along with the advice for the consumption of folic acid for pregnant women, they should be offered prenatal screening or diagnostic tests to identify fetal abnormalities for possible termination of pregnancy.

  12. Risk of Death Due to Birth Defects Higher if Baby Covered by Medicaid

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_163268.html Risk of Death Due to Birth Defects Higher If Baby Covered ... defects cause about one in every five infant deaths in the United States. Now, new research finds ...

  13. The relation between antihistamine medication during early pregnancy & birth defects

    Directory of Open Access Journals (Sweden)

    Rabah M. Shawky

    2015-10-01

    Full Text Available Antihistamines are a group of medications which can inhibit various histaminic actions at one of two histamine receptors (H1 or H2. H1 receptor antagonists are used for the relief of allergic dermatological and nondermatological conditions. We will review classes of antihistamines (H1 antagonists and the relationship between specific antihistamines and specific birth defects. Although many findings provide reassurance about the relative safety of many antihistamine drugs and that any malformation reported is most probably caused by chance, studies are still required to assure fetal safety. As pruritus is sometimes troublesome for pregnant women topical medications like emollients should be tried first in the first trimester of pregnancy. Also pregnant women should be advised to consult their health care provider before taking any medication.

  14. Folic acid and primary prevention of birth defects.

    Science.gov (United States)

    Taruscio, Domenica; Carbone, Pietro; Granata, Orietta; Baldi, Francesca; Mantovani, Alberto

    2011-01-01

    Birth defects (BDs) are an important public health problem, due to their overall incidence, occurring in 2-3% of live births in European Union. Neural tube defects (NTDs) are among major NTDs, due to their severity and relatively high incidence; in the meanwhile NTDs are also the most effectively preventable BDs to date. In particular, an adequate folic acid (FA) intake reduces both the occurrence and the recurrence of NTDs; FA is the synthetic form of folates, naturally occurring vitamins in a number of foods, especially vegetables. The daily intake of 0.4 mg of FA should be recommended to all women of childbearing age who plan to become pregnant. The Italian Network for Primary Prevention of BDs through FA Promotion has achieved a significant improvement in FA awareness and use in the periconceptional period. Nevertheless, primary prevention of BDs needs to make further progress; the Italian National Centre for Rare Diseases participates in european sureveillance of congenital anomalies (EUROCAT) Joint Action as coordinator of activities on the effectiveness of BDs prevention. Mandatory food fortification with FA has not been introduced in any European country. The health benefits of FA in reducing the risk of NTDs are undisputed; however mechanistic and animal studies suggest a relationship between high FA intakes and increased cancer promotion, while human studies are still inconsistent and inconclusive. A Working Group organized by the European Food Safety Authority pointed out significant uncertainties about fortification safety and the need for more studies; currently, FA intake from fortified foods and supplements should not exceed 1 mg/day in adults. In conclusion, based on up-to-date scientific evidence, the Italian Network strategy pivots on periconceptional supplementation integrated with promotion of healthy eating habits, support to health education, enhancing the role of women in managing life choices about their health and pregnancy and increasing

  15. Epidemiology of Birth Defects Based on a Birth Defect Surveillance System from 2005 to 2014 in Hunan Province, China.

    Directory of Open Access Journals (Sweden)

    Donghua Xie

    Full Text Available To describe the epidemiology of birth defects (BDs in perinatal infants in Hunan Province, China, between 2005 and 2014.The BD surveillance data of perinatal infants (for stillbirth, dead fetus or live birth between 28 weeks of gestation and 7 days after birth were collected from 52 registered hospitals of Hunan between 2005 and 2014. The prevalence rates of BDs with 95% confidence interval (CI and crude odds ratio (ORs were calculated to examine the associations of infant gender, maternal age, and region (urban vs rural with BDs.From 2005 to 2014, there were a total of 925413 perinatal infants of which 17753 had BDs, with the average prevalence of 191.84 per 10000 PIs (perinatal infants, showing a significant uptrend. The risks of BDs are higher in urban areas versus rural areas (OR = 1.20, in male infants versus female infants (OR = 1.19, and in mothers above age 35 versus those below age 35 (OR = 1.24. The main five types of BDs are Congenital heart defects (CHD, Other malformation of external ear (OMEE, Polydactyly, Congenital malformation of kidney (CMK, and Congenital talipes equinovarus (CTE. From 2005 to 2014, the prevalence rates (per 10000 PIs of CHD and CMK increased significantly from 22.56 to 74 (OR = 3.29, 95%CI: 2.65-4.11 and from 7.61 to 14.62 (OR = 1.92, 95%CI:1.30-2.84, respectively; the prevalence rates of congenital hydrocephalus and neural tube defects (NTDs decreased significantly from 11.8 to 5.29 (OR = 0.45, 95%CI: 0.31-0.65 and from 7.87 to 1.74 (OR = 0.22, 95%CI: 0.13-0.38, respectively.The prevalence rates of specific BDs in perinatal infants in Hunan have changed in the last decade. Urban pregnant women, male perinatal infants, and mothers above age 35 present different prevalence rates of BDs. Wider use of new diagnosis technology, improving the ability of monitoring, strengthening the publicity and education are important to reduce the prevalence of BDs.

  16. Birth Defects Surveillance in the United States: Challenges and Implications of International Classification of Diseases, Tenth Revision, Clinical Modification Implementation.

    Science.gov (United States)

    Mburia-Mwalili, Adel; Yang, Wei

    2014-01-01

    Major birth defects are an important public health issue because they are the leading cause of infant mortality. The most common birth defects are congenital heart defects, neural tube defects, and Down syndrome. Birth defects surveillance guides policy development and provides data for prevalence estimates, epidemiologic research, planning, and prevention. Several factors influence birth defects surveillance in the United States of America (USA). These include case ascertainment methods, pregnancy outcomes, and nomenclature used for coding birth defects. In 2015, the nomenclature used by most birth defects surveillance programs in USA will change from ICD-9-CM to ICD-10-CM. This change will have implications on birth defects surveillance, prevalence estimates, and tracking birth defects trends.

  17. Zika virus and birth defects: an obstetric issue

    Directory of Open Access Journals (Sweden)

    Tochukwu C. Okeke

    2016-08-01

    Full Text Available Zika virus is an emerging mosquito-borne virus that is relatively unknown, unstudied and under-diagnosed, but has potentials to spread to new geographical areas that favour survival of Aedes mosquitoes. It is associated with an alarming rise in babies with microcephaly that require much care and support with a lot of financial assistance. This is a review article on Zika virus and birth defects; a worrisome issue in today's obstetric and medical practices. Since Zika's discovery in Uganda, the virus was known to occur within a narrow equatorial belt from Africa to Asia with no or mild symptoms. It has emerged as a global public health threat over the last decade with accelerated geographic spread of the virus in the last nine years. The risk of Zika virus to the fetus is poorly understood, difficult to quantify and problematic. The causal link between Zika virus and microcephaly was initially speculative, strongly suspected and scientifically unproven. However, on 13th April, 2016, it was concluded that Zika virus is the cause of microcephaly and other severe fetal brain defects. The Center for Disease Control and Prevention (CDC authors reviewed and weighed evidences using established scientific criteria to conclude after a careful review of the report published in the New England Journal of Medicine. There is no prophylaxis, treatment or vaccine to protect against Zika virus infection. However, preventive personal measures are highly recommended to avoid mosquito bites. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2488-2496

  18. Cancer risk in children and adolescents with birth defects: a population-based cohort study.

    Directory of Open Access Journals (Sweden)

    Lorenzo D Botto

    Full Text Available OBJECTIVE: Birth defects are an increasing health priority worldwide, and the subject of a major 2010 World Health Assembly Resolution. Excess cancer risk may be an added burden in this vulnerable group of children, but studies to date have provided inconsistent findings. This study assessed the risk for cancer in children and young adolescents with major birth defects. METHODS AND FINDINGS: This retrospective, statewide, population-based, cohort study was conducted in three US states (Utah, Arizona, Iowa. A cohort of 44,151 children and young adolescents (0 through 14 years of age with selected major, non-chromosomal birth defects or chromosomal anomalies was compared to a reference cohort of 147,940 children without birth defects randomly sampled from each state's births and frequency matched by year of birth. The primary outcome was rate of cancer prior to age 15 years, by type of cancer and type of birth defect. The incidence of cancer was increased 2.9-fold (95% CI, 2.3 to 3.7 in children with birth defects (123 cases of cancer compared to the reference cohort; the incidence rates were 33.8 and 11.7 per 100,000 person-years, respectively. However, the excess risk varied markedly by type of birth defect. Increased risks were seen in children with microcephaly, cleft palate, and selected eye, cardiac, and renal defects. Cancer risk was not increased with many common birth defects, including hypospadias, cleft lip with or without cleft palate, or hydrocephalus. CONCLUSION: Children with some structural, non-chromosomal birth defects, but not others, have a moderately increased risk for childhood cancer. Information on such selective risk can promote more effective clinical evaluation, counseling, and research.

  19. Factors associated with birth defects in the region of Corpus Christi, Texas

    Science.gov (United States)

    In recent years, the Birth Defects Epidemiology & Surveillance Branch of the Texas Department of State Health Services (DSHS) has documented a high prevalence of certain birth defects in the Corpus Christi, TX region. We conducted a case-control study to evaluate associations...

  20. U.S. Health Care Costs from Birth Defects Total Almost $23 Billion a Year

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163141.html U.S. Health Care Costs From Birth Defects Total Almost $ ... 2017 (HealthDay News) -- About three of every 100 U.S. newborns have a serious birth defect, and health ...

  1. Exploratory spatial data analysis for the identification of risk factors to birth defects

    OpenAIRE

    Song Xinming; Pang Lihua; Chen Gong; Meng Bin; Wang Jinfeng; Wu Jilei; Zhang Keli; Zhang Ting; Zheng Xiaoying

    2004-01-01

    Abstract Background Birth defects, which are the major cause of infant mortality and a leading cause of disability, refer to "Any anomaly, functional or structural, that presents in infancy or later in life and is caused by events preceding birth, whether inherited, or acquired (ICBDMS)". However, the risk factors associated with heredity and/or environment are very difficult to filter out accurately. This study selected an area with the highest ratio of neural-tube birth defect (NTBD) occurr...

  2. Data input module for Birth Defects Systems Manager.

    Science.gov (United States)

    Knudsen, Kenneth B; Singh, Amar V; Knudsen, Thomas B

    2005-01-01

    The need for a computational bioinformatics infrastructure to manage the vast digital information from functional genomics and proteomics motivated us to develop Birth Defects Systems Manager (BDSM) as an open resource to facilitate analysis and discovery in developmental biology and developmental toxicity. This report describes the design, development and implementation of the data loading module of BDSM, referred to as LoadBDSM. It includes a shared data directory resource that can be granted various levels of security for different research groups or investigators to manage experimental datasets individually or in groups. LoadBDSM allows the upload of data and experiment details using controlled semantics for developmental exposure (toxicant, dosing scenario, intervention), biological sample (species, tissue, stage) and disease outcome (time, risk, phenotype). It adheres to existing controlled vocabulary plus rules of inference (ontologies) for experiment, data and metadata annotations. LoadBDSM extends the capabilities of BDSM to support the emergence of "embryo-formatics" defined here as the data, information and knowledge from genomic sciences applied to, or derived from, an embryological context. This includes, but is not limited to, delineating pathways and biological regulatory networks for specific chemicals or classes of developmental toxicants, developing novel biomarkers indicative of exposure and/or predictive of adverse effects, and integrating modern computing and information technology with data from molecular biology.

  3. Links between environmental geochemistry and rate of birth defects: Shanxi Province, China

    Energy Technology Data Exchange (ETDEWEB)

    Yu Haiying [State Key Laboratory of Earth Surface Processes and Resource Ecology, School of Geography, Beijing Normal University, Beijing 100875 (China); College of Resources and Environmental Sciences, Sichuan Agricultural University, Ya' an, Sichuan 625014 (China); Zhang Keli, E-mail: keli@bnu.edu.cn [State Key Laboratory of Earth Surface Processes and Resource Ecology, School of Geography, Beijing Normal University, Beijing 100875 (China)

    2011-01-01

    The rate of birth defects in Shanxi Province is among the highest worldwide. In order to identify the impacts of geochemical and environmental factors on birth defect risk, samples of soil, water and food were collected from an area with an unusually high rate of birth defects (study area) and an area with a low rate of birth defects (control area) in Shanxi Province, China. Element contents were determined by ICP-OES, and the results were analyzed using a non-parametric test and stepwise regression. Differences in the level and distribution of 14 geochemical elements, namely arsenic (As), selenium (Se), molybdenum (Mo), zinc (Zn), strontium (Sr), iron (Fe), tin (Sn), magnesium (Mg), vanadium (V), calcium (Ca), copper (Cu), aluminum (Al), potassium (K) and sulfur (S) were thus compared between the study and control areas. The results reveal that the geochemical element contents in soil, water and food show a significant difference between the study area and control area, and suggest that the study area was characterized by higher S and lower Sr and Al contents. These findings, based on statistical analysis, may be useful in directing further epidemiological investigations identifying the leading causes of birth defects. - Research Highlights: {yields} Environmental geochemistry has an significant impact on birth defects in the regions with an unusually high rate of birth defects. {yields} An excess of S and deficiency of Sr and Al are the distinctive environmental features associated with the high rate of birth defects in the Shanxi Province of China. {yields} Geochemical anomalies is a non-medical basis for effective prevention and cure of birth defects.

  4. What Every Chemist Should Know About Teratogens--Chemicals that Cause Birth Defects.

    Science.gov (United States)

    Beyler, Roger E.; Meyers, Vera Kolb

    1982-01-01

    Teratogens are agents which act during pregnancy producing physical/functional defects in the embryo, fetus, or offspring. Discusses teratogenic hazards in the workplace and academic environment, classes of teratogenic compounds, precautions for interpreting Teratogen List from Registry of Toxic Effects of Chemical Substances (RTECS), and how…

  5. Maternal Exposure to Methotrexate and Birth Defects: a Population-Based Study

    Science.gov (United States)

    Dawson, April L.; Riehle-Colarusso, Tiffany; Reefhuis, Jennita; Arena, J. Fernando

    2015-01-01

    Methotrexate is an anti-folate medication that is associated with increased risk of multiple birth defects. Using data from the National Birth Defects Prevention Study, a case-control study of major birth defects in the United States, we examined mothers exposed to methotrexate. The study population included mothers of live-born infants without major birth defects (controls) and mothers of fetuses or infants with a major birth defect (cases), with expected dates of delivery between October 1997 and December 2009. Mothers of cases and controls were asked detailed questions concerning pregnancy history, demographic information, and exposures in a telephone interview. Approximately 0.06% (n=16/27,623) of case and 0.04% (n=4/10,113) of control mothers reported exposure to methotrexate between three months prior to conception through the end of pregnancy. Of the 16 case infants, 11 (68.8%) had a congenital heart defect (CHD). The observed CHDs included atrial septal defects, tetralogy of Fallot, valvar pulmonary stenosis, ventricular septal defects (VSDs), and total anomalous pulmonary venous return. One case infant had microtia in addition to a VSD and another had VACTER association. Exposed cases without a CHD had one of the following birth defects: cleft palate, hypospadias, congenital diaphragmatic hernia, or craniosynostosis. Based on a limited number of methotrexate-exposed mothers, our findings support recent case reports suggesting an association between early pregnancy exposure to methotrexate and CHDs. Because of the rarity of maternal periconceptional exposure to methotrexate, long-term, population-based case-control studies are needed to confirm these findings and better evaluate the association between methotrexate and birth defects. PMID:24898111

  6. Maternal exposure to methotrexate and birth defects: a population-based study.

    Science.gov (United States)

    Dawson, April L; Riehle-Colarusso, Tiffany; Reefhuis, Jennita; Arena, J Fernando

    2014-09-01

    Methotrexate is an anti-folate medication that is associated with increased risk of multiple birth defects. Using data from the National Birth Defects Prevention Study, a case-control study of major birth defects in the United States, we examined mothers exposed to methotrexate. The study population included mothers of live-born infants without major birth defects (controls) and mothers of fetuses or infants with a major birth defect (cases), with expected dates of delivery between October 1997 and December 2009. Mothers of cases and controls were asked detailed questions concerning pregnancy history, demographic information, and exposures in a telephone interview. Approximately 0.06% (n = 16/27,623) of case and 0.04% (n = 4/10,113) of control mothers reported exposure to methotrexate between 3 months prior to conception through the end of pregnancy. Of the 16 case infants, 11 (68.8%) had a congenital heart defect (CHD). The observed CHDs included atrial septal defects, tetralogy of Fallot, valvar pulmonary stenosis, ventricular septal defects (VSDs), and total anomalous pulmonary venous return. One case infant had microtia in addition to a VSD and another had VACTER association. Exposed cases without a CHD had one of the following birth defects: cleft palate, hypospadias, congenital diaphragmatic hernia, or craniosynostosis. Based on a limited number of methotrexate-exposed mothers, our findings support recent case reports suggesting an association between early pregnancy exposure to methotrexate and CHDs. Because of the rarity of maternal periconceptional exposure to methotrexate, long-term, population-based case-control studies are needed to confirm these findings and better evaluate the association between methotrexate and birth defects.

  7. Control selection and participation in an ongoing, population-based, case-control study of birth defects: the National Birth Defects Prevention Study.

    Science.gov (United States)

    Cogswell, Mary E; Bitsko, Rebecca H; Anderka, Marlene; Caton, Alissa R; Feldkamp, Marcia L; Hockett Sherlock, Stacey M; Meyer, Robert E; Ramadhani, Tunu; Robbins, James M; Shaw, Gary M; Mathews, T J; Royle, Marjorie; Reefhuis, Jennita

    2009-10-15

    To evaluate the representativeness of controls in an ongoing, population-based, case-control study of birth defects in 10 centers across the United States, researchers compared 1997-2003 birth certificate data linked to selected controls (n = 6,681) and control participants (n = 4,395) with those from their base populations (n = 2,468,697). Researchers analyzed differences in population characteristics (e.g., percentage of births at > or =2,500 g) for each group. Compared with their base populations, control participants did not differ in distributions of maternal or paternal age, previous livebirths, maternal smoking, or diabetes, but they did differ in other maternal (i.e., race/ethnicity, education, entry into prenatal care) and infant (i.e., birth weight, gestational age, and plurality) characteristics. Differences in distributions of maternal, but not infant, characteristics were associated with participation by selected controls. Absolute differences in infant characteristics for the base population versus control participants were controls from hospitals compared with centers that selected controls from electronic birth certificates. These findings suggest that control participants in the National Birth Defects Prevention Study generally are representative of their base populations. Hospital-based control selection may slightly underascertain infants affected by certain adverse birth outcomes.

  8. Cases of Zika-Linked Birth Defects Dropped in Brazil in 2016

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_164346.html Cases of Zika-Linked Birth Defects Dropped in Brazil in 2016 ... despite the continued spread of the mosquito-borne Zika virus. Researchers predicted 1,133 cases of microcephaly ...

  9. Risk of Birth Defects 20 Times Higher for Zika Moms: CDC

    Science.gov (United States)

    ... Risk of Birth Defects 20 Times Higher for Zika Moms: CDC Finding highlights importance of preventing infection ... 2017 (HealthDay News) -- Pregnant women infected with the Zika virus are 20 times more likely to have ...

  10. Exploratory spatial data analysis for the identification of risk factors to birth defects

    Directory of Open Access Journals (Sweden)

    Song Xinming

    2004-06-01

    Full Text Available Abstract Background Birth defects, which are the major cause of infant mortality and a leading cause of disability, refer to "Any anomaly, functional or structural, that presents in infancy or later in life and is caused by events preceding birth, whether inherited, or acquired (ICBDMS". However, the risk factors associated with heredity and/or environment are very difficult to filter out accurately. This study selected an area with the highest ratio of neural-tube birth defect (NTBD occurrences worldwide to identify the scale of environmental risk factors for birth defects using exploratory spatial data analysis methods. Methods By birth defect registers based on hospital records and investigation in villages, the number of birth defects cases within a four-year period was acquired and classified by organ system. The neural-tube birth defect ratio was calculated according to the number of births planned for each village in the study area, as the family planning policy is strictly adhered to in China. The Bayesian modeling method was used to estimate the ratio in order to remove the dependence of variance caused by different populations in each village. A recently developed statistical spatial method for detecting hotspots, Getis's 7, was used to detect the high-risk regions for neural-tube birth defects in the study area. Results After the Bayesian modeling method was used to calculate the ratio of neural-tube birth defects occurrences, Getis's statistics method was used in different distance scales. Two typical clustering phenomena were present in the study area. One was related to socioeconomic activities, and the other was related to soil type distributions. Conclusion The fact that there were two typical hotspot clustering phenomena provides evidence that the risk for neural-tube birth defect exists on two different scales (a socioeconomic scale at 6.84 km and a soil type scale at 22.8 km for the area studied. Although our study has limited

  11. Maternal Food Insecurity Is Associated with Increased Risk of Certain Birth Defects1,2

    OpenAIRE

    Carmichael, Suzan L.; Yang, Wei; Herring, Amy; Abrams, Barbara; Shaw, Gary M.

    2007-01-01

    Food insecurity represents a lack of access to enough food to meet basic needs. We hypothesized that food insecurity may increase birth defect risks, because it is an indicator of increased stress or compromised nutrition, which are both implicated in birth defect etiologies. This study used population-based case-control data. Included in the analysis were 1,189 case mothers and 695 control mothers who were interviewed by telephone. We calculated a food insecurity score as the number of affir...

  12. Maternal and perinatal aspects of birth defects: a case-control study

    Directory of Open Access Journals (Sweden)

    Geiza Cesar Nhoncanse

    2014-03-01

    Full Text Available Objective: To assess the prevalence of congenital defects and to investigate their maternal and perinatal associated aspects by reviewing Birth Certificates. Methods: Among all born alive infants from January 2003 to December 2007 in Maternidade da Santa Casa de Misericórdia of São Carlos, Southeast Brazil (12,199 infants, cases were identified as the newborns whose Birth Certificates registered any congenital defect. The same sex neonate born immediately after the case was chosen as a control. In total, 13 variables were analyzed: six were maternal related, three represented labor and delivery conditions and four were linked to fetal status. The chi-square and Fisher's exact tests were used to compare the variables, being significant p<0.05. Results: The prevalence of congenital defects was 0.38% and the association of two or more defects represented 32% of all cases. The number of mothers whose education level was equal or less than eight years was significantly higher among the group with birth defects (p=0.047. A higher frequency of prematurity (p<0.001 and cesarean delivery (p=0.004 was observed among children with birth defects. This group also showed lower birth weight and Apgar scores in the 1st and the 5th minute (p<0.001. Conclusions: The prevalence of congenital defect of 0.38% is possibly due to underreporting. The defects notified in the Birth Certificates were only the most visible ones, regardless of their severity. There is a need of adequate epidemiological monitoring of birth defects in order to create and expand prevention and treatment programs.

  13. Increasing trends in childlessness in recent birth cohorts - a registry-based study of the total Danish male population born from 1945 to 1980.

    Science.gov (United States)

    Priskorn, L; Holmboe, S A; Jacobsen, R; Jensen, T K; Lassen, T H; Skakkebaek, N E

    2012-06-01

    The fertility rate has recently declined in many parts of the World, including Europe. To a large extent, this change can be explained by the socio-economic development. However, increasing fertility problems and widespread occurrence of poor semen quality could in part explain the few births. The objective of this registry based study was to investigate birth cohort related trends in fertility and childlessness among Danish men. The study population comprised all 1 616 677 men in Denmark born from 1945 to 1980 of whom 1 359 975 (84.1%) were native Danes. Data were obtained from Statistics Denmark and contained information from The National Danish Birth Registry and The Danish In Vitro Fertilization (IVF) Registry. For consecutive birth cohorts of native Danish men cumulative fertility rates at age 45 declined from 1.91 children per man in the 1945 birth cohort to 1.71 for men born in 1960. The proportion of childless men at age 45 increased from 14.8% to 21.9% in the same birth cohorts. Assisted reproductive technology (ART) seemed to compensate partly for the lower fertility and to reduce the proportion of childless men. In contrast, recent reports on corresponding birth cohorts of Danish women showed that the proportion remaining childless throughout life has been lower than in men and has not shown a similar increase. In conclusion, using unique Danish registries the study showed a birth cohort related decline in fertility rates and an increase in childlessness among men. In the more recent cohorts more than one in five men remained childless. The causes behind the findings are likely multi-factorial. Hitherto, most attention has been given to socio-economic factors which undoubtedly play a major role. Our findings lend support to the hypothesis that the high prevalence of low sperm counts among young Danish men may be a contributing factor.

  14. Folic acid supplementation influences the distribution of neural tube defect subtypes: A registry-based study.

    Science.gov (United States)

    Bergman, J E H; Otten, E; Verheij, J B G M; de Walle, H E K

    2016-01-01

    Periconceptional folic acid (FA) reduces neural tube defect (NTD) risk, but seems to have a varying effect per NTD subtype. We aimed to study the effect of FA supplementation on NTD subtype distribution using data from EUROCAT Northern Netherlands. We included all birth types with non-syndromal NTDs born in 1997-2012. By Fisher's exact test we analyzed possible differences in NTD subtype distribution between a correct FA supplementation group and incorrect FA supplementation group. We found proportionally fewer cervical/thoracic spina bifida cases and more lumbar/sacral spina bifida cases in the correct FA supplementation group, irrespective of the presence of the main NTD risk factors. The effect on NTD subtype distribution was only seen when FA supplementation was started before conception. We conclude that FA not only prevents the occurrence of a significant proportion of NTDs, but might also decrease the severity of NTDs, as long as supplementation is started before conception.

  15. Using bayesian models to assess the effects of under-reporting of cannabis use on the association with birth defects, national birth defects prevention study, 1997-2005

    NARCIS (Netherlands)

    Gelder, M.M.H.J. van; Donders, A.R.T.; Devine, O.; Roeleveld, N.; Reefhuis, J.; Prevention, S. National Birth

    2014-01-01

    BACKGROUND: Studies on associations between periconceptional cannabis exposure and birth defects have mainly relied on self-reported exposure. Therefore, the results may be biased due to under-reporting of the exposure. The aim of this study was to quantify the potential effects of this form of expo

  16. Trends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly : a registry-based study in 14 European countries 1984-2007

    NARCIS (Netherlands)

    Boyle, B.; McConkey, R.; Garne, E.; Loane, M.; Addor, M. C.; Bakker, M. K.; Boyd, P. A.; Gatt, M.; Greenlees, R.; Haeusler, M.; Klungsoyr, K.; Latos-Bielenska, A.; Lelong, N.; McDonnell, R.; Metneki, J.; Mullaney, C.; Nelen, V.; O'Mahony, M.; Pierini, A.; Rankin, J.; Rissmann, A.; Tucker, D.; Wellesley, D.; Dolk, H.

    2013-01-01

    Objective To assess the public health consequences of the rise in multiple births with respect to congenital anomalies. Design Descriptive epidemiological analysis of data from population-based congenital anomaly registries. Setting Fourteen European countries. Population A total of 5.4 million birt

  17. Mothers of Kids with Severe Birth Defects May Have Shorter Lives: Study

    Science.gov (United States)

    ... and history of pregnancy complications. Cohen noted that premature death risk was higher among women whose children were born with multiple defects, as opposed to one birth defect. "Of course, we can never make a definitive cause-and-effect determination with a single study," cautioned ...

  18. Maternal hypertensive disorders, antihypertensive medication use, and the risk of birth defects: a case-control study

    NARCIS (Netherlands)

    Gelder, M.M.H.J. van; Bennekom, C.M. Van; Louik, C.; Werler, M.M.; Roeleveld, N.; Mitchell, A.A.

    2015-01-01

    OBJECTIVE: To study previously identified associations between specific maternal hypertensive disorders and/or prenatal exposure to antihypertensive medication and birth defects. DESIGN: Case-control study. SETTING: Slone Birth Defects Study, 1998-2010. POPULATION: A total of 5568 cases with birth d

  19. Prevalence of birth defects and risk-factor analysis from a population-based survey in Inner Mongolia, China

    Directory of Open Access Journals (Sweden)

    Zhang Xingguang

    2012-08-01

    Full Text Available Abstract Background Birth Defects are a series of diseases that seriously affect children's health. Birth defects are generally caused by several interrelated factors. The aims of the article is to estimate the prevalence rate and types of birth defects in Inner Mongolia, China, to compare socio-demographic characteristics among the children with birth defects and to analyze the association between risk factors and birth defects. Methods Data used in this study were obtained through baseline survey of Inner Mongolia Birth Defects Program, a population-based survey conducted from 2005 to 2008. The survey used cluster sampling method in all 12 administrative districts of Inner Mongolia. Sampling size is calculated according to local population size at a certain percentage. All live births, stillbirths and abortions born from October 2005 to September 2008, whose families lived in Inner Mongolia at least one year, were included. The cases of birth defects were diagnosed by the clinical doctors according to their experiences with further laboratory tests if needed. The inclusion criteria of the cases that had already dead were decided according to death records available at local cites. We calculated prevalence rate and 95% confidence intervals of different groups. Outcome variable was the occurrence of birth defects and associations between risk factors and birth defects were analyzed by using Poisson regression analysis. Results 976 children with birth defects were diagnosed. The prevalence rate of birth defects was 156.1 per 10000 births (95%CI: 146.3-165.8. The prevalence rate of neural tube defect (20.1 per 10000 births including anencephaly(6.9 per 10000, spina bifida (10.6 per 10000, and encephalocele (2.7 per 10000 was the highest, followed by congenital heart disease (17.1 per 10000. The relative risk (RR for maternal age less than 25 was 2.22 (95%CI: 2.05, 2.41. The RR of the ethnic Mongols was lower than Han Chinese (RR: 0.84; 95%CI: 0

  20. The Association of Maternal Lifestyle with Birth Defects in Shaanxi Province, Northwest China.

    Directory of Open Access Journals (Sweden)

    Leilei Pei

    Full Text Available The main objective was to investigate the burden of birth defects among alive infants and explore the impact of maternal lifestyle during pregnancy on the burden of birth defects in Northwest China.A stratified multi-stage sampling method was used to study infants born during 2010-2013 (and their mothers in Shaanxi province of Northwest China. Socio-demographic information was collected using a structured questionnaire, and medical records from the local hospitals were used to determine the final diagnosis of birth defects. Poisson regression analysis was performed to assess the association between maternal lifestyles during pregnancy and the burden of birth defects, while adjusting for potential confounders.We sampled 29098 infants, of whom 629 (i.e. 216.17 per 10000 were observed to have congenital defects. Cardiovascular system defects (77.32 per 10000 were found to be the most common. Mothers who had ever consumed alcohol during pregnancy were found to have infants with a higher prevalence of some categories of birth defects, including nervous system (Prevalence Rate Ratio, PRR:14.67, 95% CI: 1.94, 110.92, cardiovascular system (PRR:3.22, 95% CI: 1.02, 10.16 and oral clefts (PRR:9.02, 95% CI: 2.08, 39.10 in contrast to infants of mothers without any alcohol consumption. Maternal passive smoking during pregnancy lead to the increased burden of malformations of eye, ear, face and neck (PRR:1.95, 95% CI: 1.15, 3.33, cardiovascular system (PRR:1.70, 95% CI: 1.25, 2.31 and respiratory system (PRR:9.94, 95% CI: 2.37, 41.76 in their newborns. Further, tea or coffee consumption during pregnancy was positively correlated with the burden of specific birth defects, such as cardiovascular system (PRR: 2.44, 95% CI: 1.33, 4.46 and genital organs (PRR:14.72, 95% CI: 1.87, 116.11 among infants.The prevalence of birth defects was high in Shaanxi province of Northwest China. The unhealthy lifestyles of mothers during pregnancy may increase the prevalence of

  1. High Prevalence of Associated Birth Defects in Congenital Hypothyroidism

    Directory of Open Access Journals (Sweden)

    Alok Sachan

    2010-01-01

    Full Text Available Aim. To identify dysmorphic features and cardiac, skeletal, and urogenital anomalies in patients with congenital hypothyroidism. Patients and Methods. Seventeen children with congenital primary hypothyroidism were recruited. Cause for congenital hypothyroidism was established using ultrasound of thyroid and T99mc radionuclide thyroid scintigraphy. Malformations were identified by clinical examination, echocardiography, X-ray of lumbar spine, and ultrasonography of abdomen. Results. Ten (59% patients (6 males and 4 females had congenital malformations. Two had more than one congenital malformation (both spina bifida and ostium secundum atrial septal defect. Five (29% had cardiac malformations, of whom three had only osteum secundum atrial septal defect (ASD, one had only patent ductus arteriosus (PDA, and one patient had both ASD and PDA. Seven patients (41% had neural tube defects in the form of spina bifida occulta. Conclusion. Our study indicates the need for routine echocardiography in all patients with congenital hypothyroidism.

  2. The Relationship between Drug-and Chemical-exposure and Birth Defects during Pregnancy

    Institute of Scientific and Technical Information of China (English)

    沈启芳; 张忠恕; 方可娟; 丁亦诺; 顾江; 王仁礼; 杨跃英; 李海放; 蒋秀蓉; 薛寿征

    1994-01-01

    A case-control study was conductedin 36 hospitals of the urban and suburban areas of Shanghai about the relationships between birth defects and drug use and chemieal exposures during pregnancy in the period of July 1987-December 1990. The case group was composed of 1.609 subjects, and the control group 3,218 cases. On statistical analysis, it was found that a correlation existed between birth defects and the intake of APC and diazepam, and the exposure to pesticides, organic soh, ents, benzene, synthetic resin and physical factors (noises) on the part of the mother, and the exposure to harmful chemicals and physical factors and the smoking of 20 or more cigarettes a day on the part of the father. It is also found that the familial hereditary history of the parents and muhigravidio,, malnutrition, common colds, hepatitis and diarrhea during pregnancy may also be related to the birth defects.

  3. [Interconnection between assisted reproductive technologies, pregnancy complications and risk of birth defects].

    Science.gov (United States)

    Grabar', V V

    2014-02-01

    The aim of the article was to investigate the relationship between pregnancy complications, infertility and assisted reproductive technologies (ART). The study was conducted on 1331 couples with complicated reproductive history. It is found that miscarriage and other complications of pregnancy depend rather on the etiopathogenesis of infertility than on the technique of ART. The highest frequency of complications of pregnancy was diagnosed in women with endocrine disorders. In case of congenital malformations in the fetus the frequency of birth defects was 3.6% after in vitro fertilization (IVF) and 1.8% in case of spontaneous pregnancy. It was found an increased risk of birth defects in singleton boys conceived by IVF.

  4. Maternal and perinatal aspects of birth defects: a case-control study

    Science.gov (United States)

    Nhoncanse, Geiza César; Germano, Carla Maria R.; de Avó, Lucimar Retto da S.; Melo, Débora Gusmão

    2014-01-01

    Objective: To assess the prevalence of congenital defects and to investigate their maternal and perinatal associated aspects by reviewing Birth Certificates. Methods: Among all born alive infants from January 2003 to December 2007 in Maternidade da Santa Casa de Misericórdia of São Carlos, Southeast Brazil (12,199 infants), cases were identified as the newborns whose Birth Certificates registered any congenital defect. The same sex neonate born immediately after the case was chosen as a control. In total, 13 variables were analyzed: six were maternal related, three represented labor and delivery conditions and four were linked to fetal status. The chi-square and Fisher's exact tests were used to compare the variables, being significant pApgar scores in the 1st and the 5th minute (p<0.001). Conclusions: The prevalence of congenital defect of 0.38% is possibly due to underreporting. The defects notified in the Birth Certificates were only the most visible ones, regardless of their severity. There is a need of adequate epidemiological monitoring of birth defects in order to create and expand prevention and treatment programs. PMID:24676186

  5. Sirenomelia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research, and Literature Review

    Science.gov (United States)

    ORIOLI, IÊDA M.; AMAR, EMMANUELLE; ARTEAGA-VAZQUEZ, JAZMIN; BAKKER, MARIAN K.; BIANCA, SEBASTIANO; BOTTO, LORENZO D.; CLEMENTI, MAURIZIO; CORREA, ADOLFO; CSAKY-SZUNYOGH, MELINDA; LEONCINI, EMANUELE; LI, ZHU; LÓPEZ-CAMELO, JORGE S.; LOWRY, R. BRIAN; MARENGO, LISA; MARTÍNEZ-FRÍAS, MARÍA-LUISA; MASTROIACOVO, PIERPAOLO; MORGAN, MARGERY; PIERINI, ANNA; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SZABOVA, ELENA; CASTILLA, EDUARDO E.

    2015-01-01

    Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance system members of the International Clearinghouse for Birth Defects Surveillance and Research, and were reported according to a single pre-established protocol. Cases were clinically evaluated locally and reviewed centrally. A total of 249 cases with sirenomelia were identified among 25,290,172 births, for a prevalence of 0.98 per 100,000, with higher prevalence in the Mexican registry. An increase of sirenomelia prevalence with maternal age less than 20 years was statistically significant. The proportion of twinning was 9%, higher than the 1% expected. Sex was ambiguous in 47% of cases, and no different from expectation in the rest. The proportion of cases born alive, premature, and weighting less than 2,500 g were 47%, 71.2%, and 88.2%, respectively. Half of the cases with sirenomelia also presented with genital, large bowel, and urinary defects. About 10–15% of the cases had lower spinal column defects, single or anomalous umbilical artery, upper limb, cardiac, and central nervous system defects. There was a greater than expected association of sirenomelia with other very rare defects such as bladder exstrophy, cyclopia/holoprosencephaly, and acardia-acephalus. The application of the new biological network analysis approach, including molecular results, to these associated very rare diseases is suggested for future studies. PMID:22002878

  6. 306例出生缺陷患儿追踪结局分析%Analysis of the outcome of 306 children born with birth defects

    Institute of Scientific and Technical Information of China (English)

    张颖; 彭振耀; 刘凯波; 潘迎

    2011-01-01

    目的 了解活产出生缺陷患儿的结局.方法 对306例2007年7月~2008年9月分娩且家长均居住在北京市海淀区的306例活产出生缺陷患儿,分娩6~8个月时通过电话调查方式询问出生缺陷惠儿家长.结果 306例出生缺陷种类主要为先天性心脏病、多指/趾、除小耳和无耳的外耳畸形、睾丸未降、尿道下裂,占调查总数的75.16%o出生缺陷患儿分娩后6~8个月时的追踪结局主要包括:死亡15例(占4.90%),到医院复诊过至少1次的208例(占67.97%),未到医院复查的76例(占27.13%),家长拒绝承认孩子有出生缺陷的7例(占2.29%).结论 先天性心脏病仍然是影响婴儿死亡和健康的最主要的出生缺陷;应提高出生缺陷的筛查、诊断水平,明确出生缺陷诊断标准;加强医生与出生缺陷患儿家长的沟通.%Objective: To describe the outcome of children born with birth defects. Methods: Between July 2007 and September 2008, 306 live bom cases of birth defects were diagnosed and registered by the Beijing Birth Defects Monitoring network-a hospital based birth defects registry system. Their parents were called to assess their survival status from birth up to the age of 6 - 8 months. Results: The major birth defects types were congenital heart defects, polydactyly, congenital malformations of ear excluding absence of ear, undescended testicle, hypospadias, the total proportions of all was 75. 16%. The proportions of all live born infants with birth defects , died at the end of the 6-8 months, having been to the hospital once at least, not having been to the hospital, not acknowledging the fact of infants' birth defects were 4. 90% , 67. 97% , 27. 13% , and 2. 29% respectively. Conclusions; Congenital heart disease make an important contribution to infant mortality and health. The level of screening and diagnosis of birth defects should be improved. The relationship of physician and parents of children bom with birth defects should

  7. Increasing trends in childlessness in recent birth cohorts - a registry-based study of the total Danish male population born from 1945 to 1980

    DEFF Research Database (Denmark)

    Priskorn, Lærke; Holmboe, Stine; Jacobsen, R;

    2012-01-01

    The fertility rate has recently declined in many parts of the World, including Europe. To a large extent, this change can be explained by the socio-economic development. However, increasing fertility problems and widespread occurrence of poor semen quality could in part explain the few births....... The objective of this registry based study was to investigate birth cohort related trends in fertility and childlessness among Danish men. The study population comprised all 1 616 677 men in Denmark born from 1945 to 1980 of whom 1 359 975 (84.1%) were native Danes. Data were obtained from Statistics Denmark....... The proportion of childless men at age 45 increased from 14.8% to 21.9% in the same birth cohorts. Assisted reproductive technology (ART) seemed to compensate partly for the lower fertility and to reduce the proportion of childless men. In contrast, recent reports on corresponding birth cohorts of Danish women...

  8. Maternal age and birth defects after the use of assisted reproductive technology in Japan, 2004–2010

    Directory of Open Access Journals (Sweden)

    Ooki S

    2013-02-01

    Full Text Available Syuichi OokiDepartment of Health Science, Ishikawa Prefectural Nursing University, Ishikawa, JapanBackground: Older mothers are becoming more common in Japan. One reason for this is the widespread use of assisted reproductive technology (ART. This study assesses the relationship between maternal age and the risk of birth defects after ART.Methods: Nationwide data on ART between 2004 and 2010 in Japan were analyzed. Diseases that were classified as code Q00-Q99 (ie, congenital malformations, deformations, and chromosomal abnormalities in the International Classification of Diseases, tenth edition, were selected. There were 219,185 pregnancies and 153,791 live births in total ART. Of these, 1943 abortions, stillbirths, or live births with birth defects were recorded. Percentage of multiple birth defects in total birth defects, the prevalence, crude relative risk and 95% confidence interval per 10,000 pregnancies and per 10,000 live births were analyzed according to the maternal age class (ie, 25–29, 30–34 (reference, 35–39, and 40+ years.Results: Multiple birth defects were observed among 14% of the 25–29 year old class, and 8% among other classes when chromosomal abnormalities were excluded. The prevalence of chromosomal abnormalities per pregnancy and per live birth became significantly and rapidly higher in mothers in the age classes of 30–35 and 40+ years. Nonchromosomal birth defects per pregnancy decreased linearly with advanced maternal age, while the number of nonchromosomal birth defects per live birth formed a gradual U-shaped distribution. The prevalence per pregnancy of congenital malformations of the nervous system was significantly lower with advanced maternal age. The relative risk per live birth was significant regarding congenital malformations of the circulatory system for a maternal age of 40+ years. Some other significant associations between maternal age and birth defects were observed.Conclusion: Maternal age is

  9. H1N1 'Swine Flu' Vaccine Unlikely to Raise Birth Defect Risk

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_161034.html H1N1 'Swine Flu' Vaccine Unlikely to Raise Birth Defect ... Swedish researchers report that the vaccine against the H1N1 "swine flu" strain of influenza doesn't seem ...

  10. COMPARISON OF GEOCODING METHODS USED IN CASE-CONTROL STUDY OF AIR QUALITY AND BIRTH DEFECTS

    Science.gov (United States)

    Introduction: Accurate geocoding of maternal residence is critical to the success of an ongoing case-control study of exposure to five criteria air pollutants and the risk of selected birth defects in seven Texas counties between 1997 and 2000. The geocoded maternal residence a...

  11. Pharmacogenetics of drug-induced birth defects : the role of polymorphisms of placental transporter proteins

    NARCIS (Netherlands)

    Daud, Aizati N. A.; Bergman, Jorieke E. H.; Bakker, Marian K.; Wang, Hao; de Walle, Hermien E. K.; Plosch, Torsten; Wilffert, Bob

    2014-01-01

    One of the ongoing issues in perinatal medicine is the risk of birth defects associated with maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the exposition of the fetus to the drug. Transporter proteins are known to be involved in the pharmacokinetics of dru

  12. Low Birth Weight and Risk of Progression to End Stage Renal Disease in IgA Nephropathy-A Retrospective Registry-Based Cohort Study.

    Directory of Open Access Journals (Sweden)

    Paschal Ruggajo

    Full Text Available Low Birth Weight (LBW is a surrogate for fetal undernutrition and is associated with impaired nephron development in utero. In this study, we investigate whether having been born LBW and/or small for gestational age (SGA predict progression to ESRD in IgA nephropathy (IgAN patients.Retrospective registry-based cohort study.The Medical Birth Registry has recorded all births since 1967 and the Norwegian Renal Registry has recorded all patients with ESRD since 1980. Based on data from the Norwegian Kidney Biopsy Registry we included all patients diagnosed with IgAN in Norway from 1988-2013. These registries were linked and we analysed risk of progression to ESRD associated with LBW (defined as birth weight less than the 10th percentile and/or SGA (defined as birth weight less than the 10th percentile for gestational week by Cox regression statistics.We included 471 patients, of whom 74 developed ESRD. As compared to patients without LBW, patients with LBW had a hazard ratio (HR of 2.0 (95% confidence interval 1.1-3.7 for the total cohort, 2.2 (1.1-4.4 for males and 1.3 (0.30-5.8 for females. Corresponding HRs for SGA were 2.2 (1.1-4.2, 2.7 (1.4-5.5 and 0.8 (0.10-5.9. Further analyses showed that as compared to patients with neither LBW nor SGA, patients with either SGA or LBW did not have significantly increased risks (HRs of 1.3-1.4 but patients who were both LBW and SGA had an increased risk (HR 3.2 (1.5-6.8.Mean duration of follow-up only 10 years and maximum age only 46 years.Among IgAN patients, LBW and/or SGA was associated with increased risk for progression to ESRD, the association was stronger in males.

  13. Correlation Between Birth Defects and Dietary Nutrition Status in a High Incidence Area of China1

    Institute of Scientific and Technical Information of China (English)

    BAO-YUAN ZHANG; QING-SHAN ZHANG; JIN ZHAO; YU-FU QIN; XIU-FENG YANG; GONG CHEN; JU-FEN LIU; XIN-MING SONG; XIAO-YING ZHENG; TING ZHANG; LIANG-MING LIN; FANG WANG; RUO-LEI XIN; XUE GU; YU-NA HE; DONG-MEI YU; PEI-ZHEN LI

    2008-01-01

    Objective To investigate the association between birth defects and dietary nutrient intake in a high risk area of China.Methods A dietary survey was performed and serum folic acid was measured in women whose pregnancy was affected by neural tube defects(NTDs)or unaffected by any birth defects(BDs)in Zhongyang and Jiaokou Counties in Shanxi Province of China.Results The local average censureption of foods including dark green vegetables,fluits,fat and meat,and nutrient intake(e.g.energy,protein,retinol,riboflavin,vitamin E,and selenium)were lower than the national average level.In women of childbearing age,these regions,the intake of nutrients was much lower than the recommended nutrient intake(9%-77%)The case-centrel dietary nutrition smdv of women whose pregnancy was affected bv BDs(including MTDs and congenital heart defects)demonstrated that,in early pregnancy,adequate nutrition(I.e.eating meat,fresh vegetables,fruit more than once a week)was a protective factor,while eating germinated potatoes was a risk factor.The geometrical mean(p5-p95)of serum folic acid in women with NTD birth defects was 9.6 nmol/L(3.6,23.03),which was significantly lower than that in normal women(14.03 nmol/L). Conclusion Wemen of childbearing age in the two counties of Shanxi Province,Chim,have a marked insufficient intake of some nutrients,especially folic acid,zinc,vitamins A and B12.This nutrient deficiency may be an important risk factor for the high prevalence of birth defects in these regions.Therefore,adequate dietary nutrition in early pregnancy can prevent BDs.

  14. Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile.

    Science.gov (United States)

    López-Camelo, Jorge S; Orioli, Iêda M; da Graça Dutra, Maria; Nazer-Herrera, Julio; Rivera, Nelson; Ojeda, María Elena; Canessa, Aurora; Wettig, Elisabeth; Fontannaz, Ana María; Mellado, Cecília; Castilla, Eduardo E

    2005-06-01

    To verify whether the decreasing neural tube defects birth prevalence rates in Chile are due to folic acid fortification or to pre-existing decreasing trends, we performed a population survey using a network of Estudio Colaborativo Latino Americano de Malformaciones Congenitas (ECLAMC, Latin American Collaborative Study of Congenital Malformations) maternity hospitals in Chile, between the years 1982 and 2002. Within each maternity hospital, birth prevalence rates of spina bifida and anencephaly were calculated from two pre-fortification periods (1982-1989 and 1990-2000), and from one fortified period (2001-2002). There was no historical trend for spina bifida birth prevalence rates before folic acid fortification, and there was a 51% (minimum 27%, maximum 66%) decrease in the birth prevalence rates of this anomaly in the fortified period. The relative risks of spina bifida were homogeneous among hospitals in the two period comparisons. There was no historical trend for the birth prevalence of anencephaly comparing the two pre-fortified periods, but the relative risks were heterogeneous among hospitals in this comparison. There was a 42% (minimum 10%, maximum 63%) decrease in the birth prevalence rate of anencephaly in the fortified period as compared with the immediately pre-fortified period, with homogeneous relative risks among hospitals. Within the methodological constraints of this study we conclude that the birth prevalence rates for both spina bifida and anencephaly decreased as a result of folic acid fortification, without interference of decreasing secular trends.

  15. Ambient air pollution and risk of birth defects in Southern California.

    Science.gov (United States)

    Ritz, Beate; Yu, Fei; Fruin, Scott; Chapa, Guadalupe; Shaw, Gary M; Harris, John A

    2002-01-01

    The authors evaluated the effect of air pollution on the occurrence of birth defects ascertained by the California Birth Defects Monitoring Program in neonates and fetuses delivered in southern California in 1987-1993. By using measurements from ambient monitoring stations of carbon monoxide (CO), nitrogen dioxide, ozone, and particulate matter <10 microm in aerodynamic diameter, they calculated average monthly exposure estimates for each pregnancy. Conventional, polytomous, and hierarchical logistic regression was used to estimate odds ratios for subgroups of cardiac and orofacial defects. Odds ratios for cardiac ventricular septal defects increased in a dose-response fashion with increasing second-month CO exposure (odds ratio (OR)(2nd quartile) CO = 1.62, 95% confidence interval (CI): 1.05, 2.48; OR(3rd quartile) CO = 2.09, 95% CI: 1.19, 3.67; OR(4th quartile) CO = 2.95, 95% CI: 1.44, 6.05). Similarly, risks for aortic artery and valve defects, pulmonary artery and valve anomalies, and conotruncal defects increased with second-month ozone exposure. The study was inconclusive for other air pollutants. The authors' results are supported by the specificity of the timing of the effect and some evidence from animal data; however, this is the first known study to link ambient air pollution during a vulnerable window of development to human malformations. Confirmation by further studies is needed.

  16. Epidemiology of external birth defects in neonates in South western Nigeria

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    Bakare T.I.B

    2009-01-01

    Full Text Available Background: There is paucity of information on the prevalence of birth defects in Nigeria, particularly in our setting. This study determined the epidemiology of external congenital anomalies in Southwest Nigerian children. Patients and Methods: This was a stratified, randomized study of neonates presenting with external birth defects in Ife-Ijesha in Southwestern Nigeria, from August 2003 to July 2004. The neonates were screened for obvious congenital malformations by thorough physical examination. Results: A total of 624 neonates were screened, 43 (6.9% of whom had external birth defects (prevalence: 3.7 ± 0.8% SD. There was a slight male preponderance (M: F= 1.4: 0.9. The overall prevalence rates of external congenital and major anomalies in Ife-Ijesa are 6.9 and 3.7% respectively. A higher prevalence for major malformations, 6.3%, was also found within the minority ethnic groups in these communities compared to the native majority. Musculoskeletal abnormalities are the most common anomaly, followed by those of abnormal external genitalia and head defects. Conclusion: Major malformations are more common amongst the minority settlers in this study, and musculoskeletal abnormalities were the most prevalent.

  17. Construction of HMI Network System for Individualized Maternity Intervention Service against Birth Defects in Community

    Institute of Scientific and Technical Information of China (English)

    Xu-huai HU

    2007-01-01

    The paper expounds the community maternity service system against birth defects,from the viewpoint of individualized service in family planning. We have utilized modern information technology to develop health management information (HMI) network with individualized maternity, and to establish the community service system for intervention of birth defects. The service system applied the concept of modern health management information to implementing informational management for screening,treatment, following up, outcome monitoring, so as to provide a base for promotion of health, diagnosis, treatment as well as scientific research, with the prenatal screening of Down's syndrome as a model. The introduction to informational network during the processes of service has been carried out with regards to its composition, function and application, while introducing the effects of computerized case record individualized in prevention, management and research of Down's syndrome.

  18. Pharmacogenetics of drug-induced birth defects: the role of polymorphisms of placental transporter proteins.

    Science.gov (United States)

    Daud, Aizati N A; Bergman, Jorieke E H; Bakker, Marian K; Wang, Hao; de Walle, Hermien E K; Plösch, Torsten; Wilffert, Bob

    2014-05-01

    One of the ongoing issues in perinatal medicine is the risk of birth defects associated with maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the exposition of the fetus to the drug. Transporter proteins are known to be involved in the pharmacokinetics of drugs and have an effect on drug level and fetal drug exposure. This condition may subsequently alter the risk of teratogenicity, which occurs in a dose-dependent manner. This review focuses on the clinically important polymorphisms of transporter proteins and their effects on the mRNA and protein expression in placental tissue. We also propose a novel approach on how the different genotypes of the polymorphism can be translated into phenotypes to facilitate genetic association studies. The last section looks into the recent studies exploring the association between P-glycoprotein polymorphisms and the risk of fetal birth defects associated with medication use during pregnancy.

  19. A Study of Handling Cytotoxic Drugs and Risk of Birth Defects in Offspring of Female Veterinarians

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    Adeleh Shirangi

    2014-06-01

    Full Text Available We examined the association of occupational exposure to handling cytotoxic drugs at work with risk of birth defects among a cohort of female veterinarians. This study is a follow up survey of 321 female participants (633 pregnancies who participated in the Health Risks of Australian Veterinarian project. Data on pregnancies and exposure during each pregnancy was obtained by self-administered mailed questionnaire. Female veterinarians handling cytotoxic drugs during their pregnancy had a two-fold increased risk of birth defects in their offspring (RR = 2.08, 95% CI (1.05–4.15. Results were consistent in subgroup analysis of those who graduated during the period of 1961 to 1980 (RR = 5.04, 95% CI (1.81, 14.03 and in those working specifically in small and large animal practice. There was no increased risk in the subgroup that graduated after 1980. Women with unplanned pregnancies were more likely to handle cytotoxic drugs on a daily basis (RR = 1.86, 95% CI, 1.00–3.48 and had a higher increased risk of birth defects than those who planned their pregnancies in recent graduates and in those who worked specifically in small animal practice (RR = 2.53, 95% CI, 1.18–5.42. This study suggests that the adverse effects of handling cytotoxic drugs in pregnant women may include an increased risk of birth defects. Pregnancy intention status is an important health behavior and should be considered in prenatal programs.

  20. Birth Defects

    Science.gov (United States)

    ... Z Topics Cerebral Palsy Congenital Adrenal Hyperplasia (CAH) Down Syndrome All related topics NICHD News and Spotlights No benefit in treating mildly low thyroid function in pregnancy, NIH Network study finds NIH workshop identifies complex health problems among ...

  1. Birth Defects in Gaza: Prevalence, Types, Familiarity and Correlation with Environmental Factors

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    Raneem Al Shawwa

    2012-05-01

    Full Text Available This is the first report of registration at birth, and of incidence of major structural birth defects (BD obtained in Gaza at Al Shifa Hospital, where 28% of total births in Gaza Strip occur. Doctors registered 4,027 deliveries, with a protocol comprehensive of clinical, demographic, kin and environmental questions. Prevalence of BD is 14/1,000, without association with intermarriage or gender of the child. Prevalence of late miscarriages and still births are respectively 23.3/1,000 and 7.4/1,000, and of premature births 19.6/1,000. Couples with a BD child have about 10 times higher frequency of recurrence of a BD in their progeny than those with normal children, but none of their 694 siblings and only 10/1,000 of their 1,423 progeny had BD, similar to the frequency in general population. These data suggest occurrence of novel genetic and epigenetic events in determination of BD. Children with BD were born with higher frequency (p < 0 001 in families where one or both parents were under “white phosphorus” attack, that in the general population. Bombing of the family home and removal of the rubble were also frequently reported by couples with BD occurrence. These data suggests a causative/favoring role of acute exposure of parents to the weapons-associated contaminants, and/or of their chronic exposure from their persistence in the environment on the embryonic development of their children.

  2. Analysis of health care status and demands of children of birth defects%出生缺陷患儿保健状况及保健需求分析

    Institute of Scientific and Technical Information of China (English)

    张颖; 丁辉

    2011-01-01

    [Objective]To acknowledge the health care status and demands of children born with birth defects.[Methods]Between July 2007 and September 2008, 453 live born cases of birth defects were diagnosed and registered by the Beijing Birth Defects Monitoring network-a hospital based birth defects registry system.Their parents were called to assess their survival status from birth up to the age of 6~8 months.[Results]The proportions of 315 live born infants with birth defects inhabited in Beijing, Expanded Program of Immunization, and physical examination were 94.00%,93.40% respectively.The proportions of having been to the hospital once at least, not having been to the hospital, not acknowledging the fact of infants' birth defects were 70.70%, 27.10%, and 2.20% respectively.[Conclusions]The medical services were not enough for the demands of children born with birth defects.To establish registry system of children born with birth defects, to accomplish the net of diagnosis, therapy and transport of children born with birth defect will provide more services to the children born with birth defects.%[目的]了解出生缺陷患儿保健状况及其家长对相关儿童保健的需求.[方法]对2007年7月-2008年9月分娩且家长均居住在北京市海淀区的453例活产出生缺陷患儿,分娩6~8个月时通过电话调查方式询问出生缺陷患儿家长.[结果]315例在北京市生活的儿童接受计划免疫接种率94.00%、体检率93.40%;70.70%"到医院复诊过至少1次",27.10%"未到医院复查",2.20%"家长否认孩子有出生缺陷".[结论]目前的医疗保健机构不能满足出生缺陷患儿医疗保健需求;建立有效的出生缺陷患儿信息登记系统对于患儿信息的长期随访至关重要;完善出生缺陷患儿诊断、治疗、转诊网络,为患儿提供更好的后续服务.

  3. Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus–associated birth defects

    Science.gov (United States)

    Correa, Adolfo; Gilboa, Suzanne M.; Botto, Lorenzo D.; Moore, Cynthia A.; Hobbs, Charlotte A.; Cleves, Mario A.; Riehle-Colarusso, Tiffany J.; Waller, D. Kim; Reece, E. Albert

    2016-01-01

    OBJECTIVE The purpose of this study was to examine the risk of birth defects in relation to diabetes mellitus and the lack of use of periconceptional vitamins or supplements that contain folic acid. STUDY DESIGN The National Birth Defects Prevention Study (1997-2004) is a multicenter, population-based case-control study of birth defects (14,721 cases and 5437 control infants). Cases were categorized into 18 types of heart defects and 26 noncardiac birth defects. We estimated odds ratios for independent and joint effects of preexisting diabetes mellitus and a lack of periconceptional use of vitamins or supplements that contain folic acid. RESULTS The pattern of odds ratios suggested an increased risk of defects that are associated with diabetes mellitus in the absence vs the presence of the periconceptional use of vitamins or supplements that contain folic acid. CONCLUSION The lack of periconceptional use of vitamins or supplements that contain folic acid may be associated with an excess risk for birth defects due to diabetes mellitus. PMID:22284962

  4. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands.

    NARCIS (Netherlands)

    Beijnum, I.M. van; Kapusta, L.; Bakker, M.K.; Heijer, M. den; Blom, H.J.; Walle, H.E. de

    2010-01-01

    AIMS: To investigate the potentially protective of periconceptional folic acid use on the risk of congenital heart defects (CHDs) relative to other non-folate related malformations. METHODS AND RESULTS: We analysed data from a large regional register of birth defects (EUROCAT-Northern Netherlands),

  5. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects : a registry-based case-control study in the northern Netherlands

    NARCIS (Netherlands)

    van Beynum, Ingrid M.; Kapusta, Livia; Bakker, Marian K.; den Heijer, Martin; Blom, Henk J.; de Walle, Hermien E. K.

    2010-01-01

    To investigate the potentially protective of periconceptional folic acid use on the risk of congenital heart defects (CHDs) relative to other non-folate related malformations. We analysed data from a large regional register of birth defects (EUROCAT-Northern Netherlands), over a 10 year period (1996

  6. Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997–2002

    Science.gov (United States)

    Gilboa, SM; Desrosiers, TA; Lawson, CC; Lupo, PJ; Riehle-Colarusso, T; Stewart, PA; van Wijngaarden, E; Waters, MA; Correa, A

    2015-01-01

    Objective To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents, and Stoddard solvent during the period from one month before conception through the first trimester. Methods The study population included mothers of infants with simple, isolated CHDs and mothers of control infants who delivered from 1997 through 2002 and participated in the National Birth Defects Prevention Study. Two methods to assess occupational solvent exposure were employed: an expert consensus-based approach and a literature-based approach. Multiple logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between solvent classes and CHDs. Results 2,951 control mothers and 2,047 CHD case mothers were included. Using the consensus-based approach, associations were observed for exposure to any solvent and any chlorinated solvent with perimembranous ventricular septal defects (OR 1.6; 95% CI 1.0 to 2.6 and OR 1.7; 95% CI 1.0 to 2.8 respectively). Using the literature-based approach, associations were observed for: any solvent exposure with aortic stenosis (OR 2.1; 95% CI 1.1 to 4.1); and Stoddard solvent exposure with d-transposition of the great arteries (OR 2.0; 95% CI 1.0 to 4.2), right ventricular outflow tract obstruction defects (OR 1.9; 95% CI 1.1 to 3.3), and pulmonary valve stenosis (OR 2.1; 95% CI 1.1 to 3.8). Conclusions We found evidence of associations between occupational exposure to solvents and several types of CHDs. These results should be interpreted in light of the potential for misclassification of exposure. PMID:22811060

  7. Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.

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    Komal Preet Allagh

    Full Text Available In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and orofacial clefts in India have reported inconsistent results. Therefore, we conducted a systematic review of observational studies to document the birth prevalence of neural tube defects and orofacial clefts.A comprehensive literature search for observational studies was conducted in MEDLINE and EMBASE databases using key MeSH terms (neural tube defects OR cleft lip OR cleft palate AND Prevalence AND India. Two reviewers independently reviewed the retrieved studies, and studies satisfying the eligibility were included. The quality of included studies was assessed using selected criteria from STROBE statement.The overall pooled birth prevalence (random effect of neural tube defects in India is 4.5 per 1000 total births (95% CI 4.2 to 4.9. The overall pooled birth prevalence (random effect of orofacial clefts is 1.3 per 1000 total births (95% CI 1.1 to 1.5. Subgroup analyses were performed by region, time period, consanguinity, and gender of newborn.The overall prevalence of neural tube defects from India is high compared to other regions of the world, while that of orofacial clefts is similar to other countries. The majority of studies included in the review were hospital based. The quality of these studies ranged from low to moderate. Further well-designed, high quality community-based observational studies are needed to accurately estimate the burden of neural tube defects and orofacial clefts in India.

  8. Prevalence and pattern of birth defects in a tertiary health facility in the Niger Delta area of Nigeria

    Science.gov (United States)

    Abbey, Mkpe; Oloyede, Olufemi A; Bassey, Goddy; Kejeh, Benjamin M; Otaigbe, Barbara E; Opara, Peace I; Eneh, Austa U; Akani, Chris I

    2017-01-01

    Objective To ascertain the prevalence and pattern of congenital abnormalities that are peculiar to the Niger Delta area of Nigeria. Methods This is a descriptive retrospective cross-sectional study. It involved data from the labor ward and neonatal birth registers of the University of Port Harcourt Teaching Hospital on the total number of births and the babies that were delivered with major birth defects between August 2011 and December 2014. We also conducted a statistical comparison of the prevalence of congenital abnormalities in the Niger Delta with that in other regions of Nigeria and the developed world of Europe. Results Out of the 7,670 deliveries that occurred, 159 maternities had babies with major birth defects giving a prevalence of 20.73 cases per 1,000 live births. This figure is far more than that which was obtained in other regions of Nigeria −4.15:cases per 1,000 live births in the South East (P51:1,000 in the North East (P<0.001). Eighty-five (53.46%) of the defects occurred in 1,681 unbooked patients, while 74 (46.54%) happened in 5,989 booked maternities (P<0.001). The predominant abnormalities were those of the central nervous system at 27.0%, gastrointestinal system 11.95%, cardiovascular system 10.69%, anterior abdominal wall 8.18%, skeleton 6.29%, and chromosomal abnormalities at 5.66%. Conclusion The prevalence of major birth defects at the University of Port Harcourt Teaching Hospital was 20.73 cases per 1,000 live births and it was more in the unbooked than the booked maternities. All body systems were affected with those of the central nervous system predominating at 27.0% of the total diagnosed defects.

  9. Assessment of student pharmacists' knowledge concerning folic acid and prevention of birth defects demonstrates a need for further education.

    Science.gov (United States)

    Lynch, Sean M

    2002-03-01

    Adequate periconceptional consumption of folic acid can prevent neural tube birth defects, and all women capable of becoming pregnant are recommended to consume 400 microg/d. Most women, however, are unaware of this recommendation and do not consume adequate amounts of folic acid. It is important, therefore, that healthcare professionals, such as pharmacists, be capable of educating women regarding folic acid. The aim of this study was to assess knowledge regarding prevention of birth defects by folic acid among student (future) pharmacists in the final year of a professional degree program. Over a 3-y period (1998-2000), students (n = 98) enrolled in a PharmD program completed a survey consisting of five multiple-choice questions concerning folic acid and birth defects. Almost all students (93.9%) correctly identified folic acid as preventing birth defects. Of these students, many also knew that supplementation should begin before pregnancy (73.9%). Fewer, however, were able to correctly identify either the recommended level of intake (55.4%) or good sources of folic acid (57.6-65.2%). These results show that although student (future) pharmacists are aware of folic acid's ability to prevent birth defects, many lack the specific knowledge needed to effectively counsel women in future clinical practice.

  10. Birth defects data for 8 California counties by county, maternal age, maternal race/ethnicity, and infant gender for the years 2000-2006.

    Data.gov (United States)

    California Environmental Health Tracking Program — This dataset contains counts, rates, and confidence intervals of 12 selected birth defects among live births during 2000-2006 within eight California counties:...

  11. Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects.

    Science.gov (United States)

    Weyer, Peter J; Brender, Jean D; Romitti, Paul A; Kantamneni, Jiji R; Crawford, David; Sharkey, Joseph R; Shinde, Mayura; Horel, Scott A; Vuong, Ann M; Langlois, Peter H

    2014-12-01

    Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997-2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers' overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS.

  12. Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects

    Science.gov (United States)

    Weyer, Peter J.; Brender, Jean D.; Romitti, Paul A.; Kantamneni, Jiji R.; Crawford, David; Sharkey, Joseph R.; Shinde, Mayura; Horel, Scott A.; Vuong, Ann M.; Langlois, Peter H.

    2016-01-01

    Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997–2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers’ overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS. PMID:25473985

  13. The effects of periconceptional risk factor exposure and micronutrient supplementation on birth defects in Shaanxi Province in Western China.

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    Wenfang Yang

    Full Text Available OBJECTIVES: 1 To understand the current prevalence and main types of birth defects, 2 assess the periconceptional exposure of factors associated with birth defects in Shaanxi Province, and 3 provide scientific evidence for local governments to formulate services for the primary prevention of birth defects. METHODS: We sampled 16,541 households from 128 townships in 16 counties/districts in Shaanxi province using a multi-stage random sampling method. Among them, 10,544 women who had live born or stillborn infants with gestational age ≥ 28 weeks between 2008 and 2009 were interviewed using a structured questionnaire designed to collect information about periconceptional risk factor exposure, health care service utilization, and micronutrient supplements. Logistic regression was performed to assess the risk factors associated with birth defects and adjustments were made for imbalanced social-demographic characteristics between case and control groups. RESULTS: The prevalence of congenital birth defect in Shaanxi province was 14.3/1000 births. The environment risk factors associated with birth defects include unhealthy lifestyle (Alcohol, odds ratio (OR: 3.60, 95% confidence interval (CI 1.64-7.91; Smoking, OR: 1.32, 95% CI: 0.99-1.75; Drink strong tea, OR: 1.81, 95% CI: 1.27-2.59, exposure to heavy pollution (OR: 1.53, 95% CI: 1.01-2.30, maternal diseases (OR: 1.77, 95% CI: 1.35-2.33, drug use (OR: 2.11, 95% CI: 1.51-2.95, maternal chemical pesticide exposure (OR: 2.30, 95% CI: 1.16-4.57, and adverse pregnancy history (OR: 10.10, 95% CI: 7.55-13.53. Periconceptional folic acid or multiple micronutrients including folic acid supplementation, was associated with a reduced rate of birth defects (OR: 0.54, 95% CI: 0.29-0.998. CONCLUSIONS: Health care service utilization, unhealthy lifestyle factors, and environment risk factors seem to be associated with birth defects in Shaanxi province. Governmental agencies should focus on effective primary

  14. Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.

    Science.gov (United States)

    Lupo, Philip J; Canfield, Mark A; Chapa, Claudia; Lu, Wei; Agopian, A J; Mitchell, Laura E; Shaw, Gary M; Waller, D Kim; Olshan, Andrew F; Finnell, Richard H; Zhu, Huiping

    2012-12-15

    Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study during 1999-2007. Log-linear models were used to evaluate maternal and offspring genetic effects. After application of the false discovery rate, there were 5 significant maternal genetic effects. The less common alleles at the 4 FTO single nucleotide polymorphisms showed a reduction of NTD risk (for rs1421085, relative risk (RR) = 0.73 (95% confidence interval (CI): 0.62, 0.87); for rs8050136, RR = 0.79 (95% CI: 0.67, 0.93); for rs9939609, RR = 0.79 (95% CI: 0.67, 0.94); and for rs17187449, RR = 0.80 (95% CI: 0.68, 0.95)). Additionally, maternal LEP rs2071045 (RR = 1.31, 95% CI: 1.08, 1.60) and offspring UCP2 rs660339 (RR = 1.32, 95% CI: 1.06, 1.64) were associated with NTD risk. Furthermore, the maternal genotype for TCF7L2 rs3814573 suggested an increased NTD risk among obese women. These findings indicate that maternal genetic variants associated with glucose homeostasis may modify the risk of having an NTD-affected pregnancy.

  15. A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study.

    Science.gov (United States)

    Lupo, Philip J; Chapa, Claudia; Nousome, Darryl; Duhon, Cody; Canfield, Mark A; Shaw, Gary M; Finnell, Richard H; Zhu, Huiping

    2012-11-01

    Tetrahydrobiopterin (BH(4)) is an essential cofactor and an important cellular antioxidant. BH(4) deficiency has been associated with diseases whose etiologies stem from excessive oxidative stress. GTP cyclohydrolase I (GCH1) catalyzes the first and rate-limiting step of de novo BH(4) synthesis. A 3-SNP haplotype in GCH1 (rs8007267, rs3783641, and rs10483639) is known to modulate GCH1 gene expression levels and has been suggested as a major determinant of plasma BH(4) bioavailability. As plasma BH(4) bioavailability has been suggested as a mechanism of neural tube defect (NTD) teratogenesis, we evaluated the association between this GCH1 haplotype and the risk of NTDs. Samples were obtained from 760 NTD case-parent triads included in the National Birth Defects Prevention Study (NBDPS). The three SNPs were genotyped using TaqMan® SNP assays. An extension of the log-linear model was used to assess the association between NTDs and both offspring and maternal haplotypes. Offspring carrying two copies of haplotype C-T-C had a significantly increased NTD risk (risk ratio [RR]=3.40, 95% confidence interval [CI]: 1.02-11.50), after adjusting for the effect of the maternal haplotype. Additionally, mothers carrying two copies of haplotype C-T-C had a significantly increased risk of having an NTD-affected offspring (RR=3.46, 95% CI: 1.05-11.00), after adjusting for the effect of the offspring haplotype. These results suggest offspring and maternal variation in the GCH1 gene and altered BH(4) biosynthesis may contribute to NTD risk.

  16. Diabetes and Obesity-Related Genes and the Risk of Neural Tube Defects in the National Birth Defects Prevention Study

    Science.gov (United States)

    Lupo, Philip J.; Canfield, Mark A.; Chapa, Claudia; Lu, Wei; Agopian, A. J.; Mitchell, Laura E.; Shaw, Gary M.; Waller, D. Kim; Olshan, Andrew F.; Finnell, Richard H.; Zhu, Huiping

    2012-01-01

    Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study during 1999–2007. Log-linear models were used to evaluate maternal and offspring genetic effects. After application of the false discovery rate, there were 5 significant maternal genetic effects. The less common alleles at the 4 FTO single nucleotide polymorphisms showed a reduction of NTD risk (for rs1421085, relative risk (RR) = 0.73 (95% confidence interval (CI): 0.62, 0.87); for rs8050136, RR = 0.79 (95% CI: 0.67, 0.93); for rs9939609, RR = 0.79 (95% CI: 0.67, 0.94); and for rs17187449, RR = 0.80 (95% CI: 0.68, 0.95)). Additionally, maternal LEP rs2071045 (RR = 1.31, 95% CI: 1.08, 1.60) and offspring UCP2 rs660339 (RR = 1.32, 95% CI: 1.06, 1.64) were associated with NTD risk. Furthermore, the maternal genotype for TCF7L2 rs3814573 suggested an increased NTD risk among obese women. These findings indicate that maternal genetic variants associated with glucose homeostasis may modify the risk of having an NTD-affected pregnancy. PMID:23132673

  17. Genomic Imbalances in Neonates With Birth Defects: High Detection Rates by Using Chromosomal Microarray Analysis

    Science.gov (United States)

    Lu, Xin-Yan; Phung, Mai T.; Shaw, Chad A.; Pham, Kim; Neil, Sarah E.; Patel, Ankita; Sahoo, Trilochan; Bacino, Carlos A.; Stankiewicz, Pawel; Lee Kang, Sung-Hae; Lalani, Seema; Chinault, A. Craig; Lupski, James R.; Cheung, Sau W.; Beaudet, Arthur L.

    2009-01-01

    OBJECTIVES Our aim was to determine the frequency of genomic imbalances in neonates with birth defects by using targeted array-based comparative genomic hybridization, also known as chromosomal microarray analysis. METHODS Between March 2006 and September 2007, 638 neonates with various birth defects were referred for chromosomal microarray analysis. Three consecutive chromosomal microarray analysis versions were used: bacterial artificial chromosome-based versions V5 and V6 and bacterial artificial chromosome emulated oligonucleotide-based version V6 Oligo. Each version had targeted but increasingly extensive genomic coverage and interrogated >150 disease loci with enhanced coverage in genomic rearrangement-prone pericentromeric and subtelomeric regions. RESULTS Overall, 109 (17.1%) patients were identified with clinically significant abnormalities with detection rates of 13.7%, 16.6%, and 19.9% on V5, V6, and V6 Oligo, respectively. The majority of these abnormalities would not be defined by using karyotype analysis. The clinically significant detection rates by use of chromosomal microarray analysis for various clinical indications were 66.7% for “possible chromosomal abnormality” ± “others” (other clinical indications), 33.3% for ambiguous genitalia ± others, 27.1% for dysmorphic features + multiple congenital anomalies ± others, 24.6% for dysmorphic features ± others, 21.8% for congenital heart disease ± others, 17.9% for multiple congenital anomalies ± others, and 9.5% for the patients referred for others that were different from the groups defined. In all, 16 (2.5%) patients had chromosomal aneuploidies, and 81 (12.7%) patients had segmental aneusomies including common microdeletion or microduplication syndromes and other genomic disorders. Chromosomal mosaicism was found in 12 (1.9%) neonates. CONCLUSIONS Chromosomal microarray analysis is a valuable clinical diagnostic tool that allows precise and rapid identification of genomic imbalances

  18. Effect of consanguinity on birth defects in Saudi women; results from a nested case-control study

    DEFF Research Database (Denmark)

    Majeed-Saidan, Muhammad Ali; Ammari, Amer N; AlHashem, Amal M;

    2015-01-01

    : This case and control study was nested within a 3-year prospective cohort study to examine patterns of fetal and neonatal malformations in Saudi women at Prince Sultan Military Medical City (PSMMC), Riyadh -Saudi Arabia. Consanguineous marriages were defined as marriages with first or second cousins......BACKGROUND: The role of consanguinity in the etiology of structural birth defects outside of chromosomal and inherited disorders has always been debated. We studied the independent role of consanguinity on birth defects in Saudi women with a high prevalence of consanguineous marriages. METHODS...

  19. Chemicals which cause birth defects--teratogens: a special concern of research chemists

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, V.K.

    1983-12-15

    Women who are research chemists suffer an unusually high risk of being exposed to teratogenic chemicals (chemicals which cause birth defects) for the principal reason that they spend a good share of their lives in the laboratory in contact with wide variety of chemicals including new chemicals which may be unsuspected teratogens. Women research chemists therefore need to be able (a) to recognize known teratogens and (b) to predict teratogenicity of a compound that has not been tested. This article discusses these two points with an emphasis on the following topics: how to obtain information on teratogenicity of chemicals; how to interpret teratogenicity data from the literature; and how to make an educated guess about the teratogenicity of chemical compounds.

  20. CASE-CONTROL STUDY OF AIR QUALITY AND BIRTH DEFECTS: COMPARISON OF GEOCODED AND NON-GEOCODED POPULATIONS

    Science.gov (United States)

    Unbiased geocoding of maternal residence is critical to the success of an ongoing case-control study of exposure to five criteria air pollutants and the risk of selected birth defects in seven Texas counties between 1997 and 2000. The geocoded residence at delivery will be used ...

  1. Preventing Fetal Alcohol Syndrome and Other Alcohol-Related Birth Defects: Teacher's Manual and Student Text. High School Edition.

    Science.gov (United States)

    Howard, Elizabeth; And Others

    This teacher's manual presents lesson plans for a high-school instructional unit on Fetal Alcohol Syndrome and its less severe manifestations, Alcohol-Related Birth Defects. The lessons cover alcohol's effects during pregnancy, the history of concern about alcohol's effects, consequences of alcohol use in pregnancy, lifestyle risk reduction, and…

  2. Agricultural chemical exposures and birth defects in the Eastern Cape Province, South Africa A case – control study

    Directory of Open Access Journals (Sweden)

    Tyler Joanne

    2003-10-01

    Full Text Available Abstract Background South Africa is one of the major users of pesticides on the African continent. The Eastern Cape is the second largest province in South Africa. There has been growing concern about the occurrence of certain birth defects which seemed to have increased in the past few years. In this paper we investigate associations between exposure to agricultural chemicals and certain birth defects. Few such studies have been undertaken in the developing world previously. Methods Between September 2000 and March 2001 a case – control study was conducted among rural women in the area of the Eastern cape to investigate the association between women's exposure to pesticides and the occurrence of birth defects. Information on birth defects was obtained from the register of the Paediatrics Department at the Cecilia Makiwane Hospital in Mdantsane, one of the largest referral hospitals in the province. The cases were children who were diagnosed with selected birth defects. The controls were children born in the same areas as the cases. Exposure information on the mothers was obtained by interview concerning from their activities in gardens and fields. Data were analysed using conditional logistic regression. Results A total of 89 case mothers and 178 control mothers was interviewed. Babies with birth defects were seven times more likely to be born to women exposed to chemicals used in gardens and fields compared to no reported exposure (Odds Ratio 7.18, 95% CI 3.99, 13.25; and were almost twice as likely to be born to women who were involved in dipping livestock used to prevent ticks (OR 1.92, 95% CI 1.15, 3.14. They were also 6.5 times more likely to be born to women who were using plastic containers for fetching water (OR 6.5, 95% CI 2.2, 27.9. Some of these containers had previously contained pesticides (OR 1.87, 95% CI 1.06, 3.31. Conclusions These findings suggest a link between exposure to pesticides and certain birth defects among the

  3. Combined effect of prenatal solvent exposure and GSTT1 or GSTM1 polymorphisms in the risk of birth defects.

    Science.gov (United States)

    Garlantézec, Ronan; Chevrier, Cécile; Coiffec, Isabelle; Celebi, Catherine; Cordier, Sylvaine

    2012-06-01

    Exposure to solvents during pregnancy has long been suspected to increase the risk of congenital malformations. Glutathione S-transferases (GSTs) are enzymes essential for the detoxification of various chemicals. Our objective here was to assess whether GST polymorphisms might modify the association between maternal solvent exposure and the risk of birth defects. A prospective cohort included 3421 pregnant women in Brittany, France (2002-2006). Occupational exposure to solvents was assessed from a job-exposure matrix. Congenital malformations were diagnosed among livebirths, stillbirths, and medical pregnancy terminations. Using a nested case-control design, 32 babies with major birth defects were compared to 348 normal births for babies' cord blood genotypes (at GSTT1 and GSTM1) and maternal occupational solvent exposure. Logistic models were used to adjust for potential confounders. The risk of major defects increased significantly in women with solvent exposure (20% of controls and 34% of cases). Frequencies of the null genotype of both the GSTT1 and GSTM1 genes were similar among controls and cases. There was a significantly increased risk of birth defects in GSTM1 not-null cord-blood genotype in pregnancies exposed to solvents (odds ratio [OR], 1.0 for not-null, not-exposed; OR, 4.0 for not-null, exposed; 95% confidence interval [CI], 1.4-11.2; OR, 1.6 for null, not-exposed; 95% CI, 0.6-3.9; OR, 1.0 for null, exposed; 95% CI, 0.2-4.7; p = 0.05). This nested case-control study suggests that the child's GSTM1 genotype modifies the risk of major birth defects among offspring of solvent-exposed women. Replication and additional investigations are necessary to confirm and elucidate these findings.

  4. Cyclopia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research

    Science.gov (United States)

    Orioli, Iêda M.; Amar, Emmanuelle; Bakker, Marian K.; Bermejo-Sánchez, Eva; Bianchi, Fabrizio; Canfield, Mark A.; Clementi, Maurizio; Correa, Adolfo; Csáky-Szunyogh, Melinda; Feldkamp, Marcia L.; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Morgan, Margery; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Castilla, Eduardo E.

    2015-01-01

    Cyclopia is characterized by the presence of a single eye, with varying degrees of doubling of the intrinsic ocular structures, located in the middle of the face. It is the severest facial expression of the holoprosencephaly (HPE) spectrum. This study describes the prevalence, associated malformations, and maternal characteristics among cases with cyclopia. Data originated in 20 Clearinghouse (ICBDSR) affiliated birth defect surveillance systems, reported according to a single pre-established protocol. A total of 257 infants with cyclopia were identified. Overall prevalence was 1 in 100,000 births (95%CI: 0.89–1.14), with only one program being out of range. Across sites, there was no correlation between cyclopia prevalence and number of births (r = 0.08; P=0.75) or proportion of elective termination of pregnancy (r= −0.01; P=0.97). The higher prevalence of cyclopia among older mothers (older than 34) was not statistically significant. The majority of cases were liveborn (122/200; 61%) and females predominated (male/total: 42%). A substantial proportion of cyclopias (31%) were caused by chromosomal anomalies, mainly trisomy 13. Another 31% of the cases of cyclopias were associated with defects not typically related to HPE, with more hydrocephalus, heterotaxia defects, neural tube defects, and preaxial reduction defects than the chromosomal group, suggesting the presence of ciliopathies or other unrecognized syndromes. Cyclopia is a very rare defect without much variability in prevalence by geographic location. The heterogeneous etiology with a high prevalence of chromosomal abnormalities, and female predominance in HPE, were confirmed, but no effect of increased maternal age or association with twinning was observed. PMID:22006661

  5. The Danish Cerebral Palsy Registry. A registry on a specific impairment

    DEFF Research Database (Denmark)

    Uldall, P; Michelsen, S I; Topp, M;

    2001-01-01

    Cerebral palsy (CP) is the commonest disabling impairment in childhood, with a prevalence of 2-3 per 1000 live births. The Danish Cerebral Palsy Registry is a research registry that contains cases of CP from birth year 1925 and has estimated the birth prevalence since 1950. Data on children with CP...

  6. Low birth weight and zygosity status is associated with defective muscle glycogen and glycogen synthase regulation in elderly twins

    DEFF Research Database (Denmark)

    Poulsen, Pernille; Wojtaszewski, Jørgen; Richter, Erik;

    2007-01-01

    AND METHODS: We measured the activities of glycogen synthase (GS), GS kinase (GSK)3 alpha, GS phosphorylation, and glycogen levels in muscle biopsies obtained from 184 young and elderly twins before and after a euglycemic-hyperinsulinemic clamp. RESULTS: Elderly monozygotic twins had significantly lower...... fractional GS activity amidst higher glycogen and GS protein levels compared with dizygotic twins. In addition, we demonstrated strong nongenetic associations between birth weight and defect muscle glycogen metabolism in elderly--but not in younger--twins. Thus, for every 100 g increase in birth weight...... within pairs, GS fractional activity, GS protein level, and glycogen content was increased by 4.2, 8.7, and 4.5%, respectively, in elderly twins. Similarly, for every 100 g increase in birth weight, GSK3 alpha activity and GS phosphorylation at the sites 2, 2+2a, and 3a+3b were decreased by 3.1, 9.0, 10...

  7. The experience of black parents/caretakers with the births and care of a child with profound congenital defects

    Directory of Open Access Journals (Sweden)

    M.S. Mabaso

    1990-09-01

    Full Text Available The reaction of Black families to the birth and care of a baby with profound congenital defects was researched using twenty case studies. It was found that the families went through stages of the grieving process, that they shifted from the Western/Christian viewpoint to the traditional viewpoint in their struggle to cope and that they find the existing services grossly inadequate.

  8. Severe birth defects in children perinatal exposed to HIV from a “real-world” setting: Infectious Diseases National Institute, Bucharest, Romania

    Directory of Open Access Journals (Sweden)

    Ana Maria Tudor

    2014-11-01

    Full Text Available Introduction: The shift in epidemic trends in recent years in Romania shows new problems in regard of HIV vertical transmission, firstly in intravenous drug user's mothers co-infected with hepatitis viruses and with social problems, and secondly the children of young mothers with an old HIV infection and long antiretroviral therapy history. Materials and Methods: We studied all HIV perinatal exposed children routinely followed up in the Paediatric Department of the National Institute of Infectious Diseases, since January 1st 2006 till December 31st 2012. The analyses consisted of describing the birth defects and association with certain risk factors: gender, mother's age at birth and exposure to antiretrovirals in the first trimester of pregnancy. Results: We analyzed 244 children born to HIV-infected mothers. The incidence of HIV infection was 16.39%. The rate of birth defects was 39.34% (96/244 cases. The most frequent findings were cardiac malformations (47/96, followed by musculoskeletal defects (24/96, neurologic defects (20/96, urogenital malformations (13/96, digestive tract defects (3/93, metabolic disorders (2/96 and genetic disorders (2/96. We found nine cases of severe congenital anomalies: complex heart defect, total congenital aganglionic megacolon, anal imperforation, Dandy-Walker syndrome, gangliosidosis, Niemann-Pick syndrome, Down syndrome, true hermaphroditism and cleft palate. Two children died during first year of life due to severe malformations. 9% of cases had associated malformations. The gender rate was in favour of males in group with birth defects (58/38 and with no birth defects (82/66. The median age at birth in mothers was 22 years, similar in both groups. The highest mean age at birth was in offspring's mothers with neurologic congenital defects 25, 15 years old, but is not statistically significant (p=0.1. In the studied period the highest number of birth defects were found in 2012, 37 children, compared with less

  9. Computational systems analysis of developmental toxicity: design, development and implementation of a Birth Defects Systems Manager (BDSM).

    Science.gov (United States)

    Singh, Amar V; Knudsen, Kenneth B; Knudsen, Thomas B

    2005-01-01

    Birth defects and developmental disabilities remain an important public health issue worldwide. With the availability of genomic sequences from a growing number of human and model organisms and the rapid expansion of the public repositories holding large-scale gene expression datasets, a computational systems analysis of developmental toxicology can incorporate this vast digital information toward the realization of predictive models for complex disease. Here we describe the initial design, development and implementation of a Birth Defects Systems Manager (BDSM). The project was motivated by the need for a computational-bioinformatics infrastructure to manage vast digital information from functional genomics and for a new knowledge environment specifically engineered for the analysis of developmental processes and toxicities. Proof-of-concept tested BDSM using meta-analysis of gene expression data collected from different laboratories, technology platforms, and study models. The composite dataset incorporated 232 microarray comparisons of RNA samples by single or dual microarray platforms, cDNA or oligonucleotide based probes, and human or mouse sequence information. Preliminary results identified system-level features in the embryonic transcriptome as it reacted to various developmental-teratological stimuli. BDSM is open access through the worldwide web (http://systemsanalysis.louisville.edu/) and can be integrated with other bioinformatics tools and resources to advance the pace of discovery in birth defects research.

  10. The Brazilian Zika virus strain causes birth defects in experimental models.

    Science.gov (United States)

    Cugola, Fernanda R; Fernandes, Isabella R; Russo, Fabiele B; Freitas, Beatriz C; Dias, João L M; Guimarães, Katia P; Benazzato, Cecília; Almeida, Nathalia; Pignatari, Graciela C; Romero, Sarah; Polonio, Carolina M; Cunha, Isabela; Freitas, Carla L; Brandão, Wesley N; Rossato, Cristiano; Andrade, David G; Faria, Daniele de P; Garcez, Alexandre T; Buchpigel, Carlos A; Braconi, Carla T; Mendes, Erica; Sall, Amadou A; Zanotto, Paolo M de A; Peron, Jean Pierre S; Muotri, Alysson R; Beltrão-Braga, Patricia C B

    2016-05-11

    Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. However, in 2007, vectored by Aedes aegypti mosquitoes, ZIKV caused the first noteworthy epidemic on the Yap Island in Micronesia. Patients experienced fever, skin rash, arthralgia and conjunctivitis. From 2013 to 2015, the Asian lineage of the virus caused further massive outbreaks in New Caledonia and French Polynesia. In 2013, ZIKV reached Brazil, later spreading to other countries in South and Central America. In Brazil, the virus has been linked to congenital malformations, including microcephaly and other severe neurological diseases, such as Guillain-Barré syndrome. Despite clinical evidence, direct experimental proof showing that the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent. Here we demonstrate that ZIKV(BR) infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells, leading to an increase in cell death. We also report that the infection of human brain organoids results in a reduction of proliferative zones and disrupted cortical layers. These results indicate that ZIKV(BR) crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, and impairing neurodevelopment. Our data reinforce the growing body of evidence linking the ZIKV(BR) outbreak to the alarming number of cases of congenital brain malformations. Our model can be used to determine the efficiency of therapeutic approaches to counteracting the harmful impact of ZIKV(BR) in human neurodevelopment.

  11. The Norwegian Twin Registry.

    Science.gov (United States)

    Nilsen, Thomas S; Brandt, Ingunn; Magnus, Per; Harris, Jennifer R

    2012-12-01

    Norway has a long-standing tradition in twin research, but the data collected in several population-based twin studies were not coordinated centrally or easily accessible to the scientific community. In 2009, the Norwegian Twin Registry was established at the Norwegian Institute of Public Health (NIPH) in Oslo with the purpose of creating a single research resource for Norwegian twin data. As of today, the Norwegian Twin Registry contains 47,989 twins covering birth years 1895-1960 and 1967-1979; 31,440 of these twins consented to participate in health-related research. In addition, DNA from approximately 4,800 of the twins is banked at the NIPH biobank and new studies are continually adding new data to the registry. The value of the Norwegian twin data is greatly enhanced by the linkage opportunities offered by Norway's many nationwide registries, spanning a broad array of medical, demographic, and socioeconomic information.

  12. Monitoring and analysis on birth defects in shanghai in 2009%2009年上海市出生缺陷监测分析

    Institute of Scientific and Technical Information of China (English)

    虞慧婷; 蔡任之; 杨青; 宋桂香

    2011-01-01

    Objective: To analyze the prevalence of birth defects and explore the related risk factors of birth defects in shanghai in 2009.Methods: The monitoring data of birth defects in hospitals of Shanghai in 2009 were collected, the intrauterine development of neonates with birth defects were understood, logistic regression analysis was used to analyze and explore the related risk factors of birth defects.Results: The incidence of birth defects in Shanghai in 2009 was 12.41‰, which was higher than those in former years; the incidence of congenital heart disease was the highest among various birth defects, the intrauterine development of neonates without birth defects was better than that of neonates with birth defects.Conclusion: In recent years, the incidence of birth defects increases, the phenomenon needs more attention, propaganda and education should be enhanced, and prenatal screening and prevention of birth defects should be strengthened too.%目的:分析上海市2009年新生儿出生缺陷的发生情况,探讨出生缺陷发生的相关危险因素.方法:收集2009年上海市接产医院出生监测数据,了解出生缺陷新生儿宫内发育情况,运用Logistic回归分析探索出生缺陷的相关危险因素.结果:上海市2009年出生缺陷的发生率为12.41‰,比历年有所升高,全市首位出生缺陷为先天性心脏病,无出牛缺陷新生儿宫内发育要优于有出生缺陷的新生儿.结论:近年来出生缺陷发生率的上升需要得到重视,应加强宣教,做好出生缺陷的产前筛查与预防.

  13. Cloacal Exstrophy : An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research

    NARCIS (Netherlands)

    Feldkamp, Marcia L.; Botto, Lorenzo D.; Amar, Emmanuelle; Bakker, Marian K.; Bermejo-Sanchez, Eva; Bianca, Sebastiano; Canfield, Mark A.; Castilla, Eduardo E.; Clementi, Maurizio; Csaky-Szunyogh, Melinda; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Merlob, Paul; Morgan, Margery; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Siffel, Csaba; Carey, John C.

    2011-01-01

    Cloacal exstrophy presents as a complex abdominal wall defect thought to result from a mesodermal abnormality. Anatomically, its main components are Omphalocele, bladder Exstrophy and Imperforate anus. Other associated malformations include renal malformations and Spine defects (OEIS complex). Histo

  14. Research Progress on Environment Factors Leading to Birth Defects%导致出生缺陷的环境因素研究进展

    Institute of Scientific and Technical Information of China (English)

    蔡晶

    2012-01-01

    Birth defects is the structural or functional abnormalities already existed before birth (which can be found in a lifetime years before or after birth) ,and its causes including genetic, environmental and both of joint action. Environmental factors have become threats to humanity even in the reproduction of the species. Nowadays .birth defects has become one of the hot topics. This review focuses on recent environmental factors on the impact of birth defects,and focus on the ultrasound and psychological factors associated with birth defects.%出生缺陷(birth defects)是指出生前已经存在(在出生前或出生后数年内可以发现)的结构或功能异常,其产生原因包括遗传、环境以及两者的共同作用.环境问题已经变成威胁人类生存甚至繁衍的一个重要问题.出生缺陷也已成为当今世界关注的热点课题之一.综述近年有关环境因素对出生缺陷影响的研究,并重点探讨超声波及心理因素与出生缺陷的相关性.

  15. Birth defects in Norway by levels of external and food-based exposure to radiation from Chernobyl

    Energy Technology Data Exchange (ETDEWEB)

    Lie, R.T.; Irgens, L.M.; Skjaerven, R.; Reitan, J.B.; Strand, P.; Strand, T. (Medical Birth Registry of Norway, University of Bergen (Norway))

    1992-08-15

    In Norway, external doses of radiation resulting from fallout from the Chernobyl nuclear accident were estimated from detailed measurements, including soil deposition patterns. Internal doses were estimated from measurements of radioactive cesium in meat and milk supplies. The doses were calculated as average monthly doses for each of 454 municipalities during 36 consecutive months after the accident in spring 1986. Prospectively collected data on all newborns listed in the Medical Birth Registry of Norway who were conceived in the period May 1983-April 1989 were used to assess possible dose-response relations between estimated external and food-based exposures and congenital malformations and some other conditions. A positive association was observed between total radiation dose (external plus food-based) and hydrocephaly, while a negative association was observed for Down's syndrome. However, an important conclusion of the study was that no associations were found for conditions previously reported to be associated with radiation, i.e., small head circumference, congenital cataracts, anencephaly, spina bifida, and low birth weight. Potential sources of bias, including exposure misclassification and incomplete ascertainment of cases, are discussed.

  16. Nanomaterial Registry

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Nanomaterial Registry compiles data from multiple databases into a single resource. The goal of this resource is to establish a curated nanomaterial registry,...

  17. Diverse ability of maternal immune stimulation to reduce birth defects in mice exposed to teratogens: a review.

    Science.gov (United States)

    Hrubec, T C; Prater, M R; Mallela, M K; Gogal, R M; Guo, T L; Holladay, S D

    2012-06-01

    Stimulating the maternal immune system before or during pregnancy can dramatically improve morphologic outcome in mice that have been exposed to teratogens. For example, maternal immune stimulation in mice reduced craniofacial and palate defects, heart defects, digit and limb defects, tail malformations and neural tube defects caused by diverse teratogens that included chemical agents, hyperthermia, X-rays and diabetes mellitus. Several different procedures of immune stimulation were effective and included footpad injection with Freund's Complete Adjuvant, intraperitoneal (IP) injection with inert particles or attenuated Bacillus Calmette-Guerin, intrauterine injection with allogenic or xenogenic lymphocytes, or intravascular, intrauterine or IP injection with immunomodulatory cytokines. Limited information is available regarding mechanisms by which such immune stimulation reduces fetal dysmorphogenesis; however, cytokines of maternal origin have been suggested as effector molecules that act on the placenta or fetus to improve development. These collective data raise novel questions about the possibility of unrecognized maternal immune system regulatory activity in normal fetal development. This manuscript reviews the literature showing maternal immune protection against morphologic birth defects. Potential operating mechanisms are discussed, and the possibility is considered that a suppressed maternal immune system may negatively impact fetal development.

  18. 北京61272例新生儿出生缺陷监测结果分析%Analysis of the birth defects among 61 272 live born infants in Beijing

    Institute of Scientific and Technical Information of China (English)

    李瑛; 刘晓红; 王粉燕; 赵心亮; 张羲; 张运平

    2009-01-01

    Objective: To investigate the birth defect condition in Haidian district of Beijing city, 61 272 live-born infants who were delivered in Haidian Maternal and Child Health Hospital from 2003 to the March of 2009 are analyzed. Methods: Data was collected from the hospital' s medical records and from the birth defect surveillance. Results: Among the newborns studied, 1 076 were found having birth defect (17.56‰). The most common birth defects are congenital heart defect, followed by dysmorphosis of external ear, polydactyly, hypospadia, cleft lip and palate. In addition, three birth defects that are not included in the birth defect surveillance list were enorchia, renal agenesis and giant hemangioma. The birth defect rates of preterm and small for gestational age infants are significantly higher than it of the term infants. The birth defect patterns for these two types of abnormal infants are distinct. Conclusion: We have determined the pattern of birth defects in Beijing, which may help in policy-making regarding the prevention and intervention of birth defects.

  19. Zika Babies May Look Normal At Birth, Display Brain Defects Later: CDC

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162159.html Zika Babies May Look Normal at Birth, Display Brain ... 22, 2016 (HealthDay News) -- Babies exposed to the Zika virus in the womb can look normal at ...

  20. First-Trimester Use of Paroxetine and Congenital Heart Defects : A Population-Based Case-Control Study

    NARCIS (Netherlands)

    Bakker, Marian K.; Kerstjens-Frederikse, Wilhelmina S.; Buys, Charles H. C. M.; de Walle, Hermien E. K.; de Jong-van den Berg, Lolkje T. W.

    2010-01-01

    BACKGROUND: There is a need for case-control studies of the effect of paroxetine on the occurrence of specific heart defects. METHODS: We performed a case-control study with data from a population-based birth defects registry in the Netherlands. All the children born between 1997 and 2006 were selec

  1. The Nexus of Prematurity, Birth Defects, and Intrauterine Growth Restriction: A Role for Plac1-Regulated Pathways

    Science.gov (United States)

    Fant, Michael E.; Fuentes, Juan; Kong, Xiaoyuan; Jackman, Suzanne

    2013-01-01

    Epidemiological studies have demonstrated an increased prevalence of birth defects and intrauterine growth restriction (IUGR) among infants born prematurely suggesting they share common biological determinants. The identification of key regulatory pathways contributing to this nexus is essential to ongoing efforts to develop effective intervention strategies. Plac1 is a paternally imprinted and X-linked gene that conforms to this paradigm. Examination of a mutant mouse model has confirmed that Plac1 is essential for normal placental development and function. Moreover, it is expressed throughout the developing embryo indicating that it also has broad relevance to embryogenesis. Most notably, its absence in the developing embryo is associated with abnormal brain development and an increased risk of lethal, postnatal hydrocephalus identifying it as a novel, X-linked determinant of brain development. The essential and non-redundant roles of Plac1 in placental and neurological development represent a novel regulatory paradigm for embryonic growth and pregnancy maintenance. Regulatory pathways influenced, in part, by Plac1 are likely to contribute to the observed nexus of IUGR, prematurity, and birth defects. PMID:24600606

  2. The Danish Twin Registry

    DEFF Research Database (Denmark)

    Skytthe, Axel; Ohm Kyvik, Kirsten; Vilstrup Holm, Niels;

    2011-01-01

    Introduction: The Danish Twin Registry is a unique source for studies of genetic, familial and environmental factors on life events, health conditions and diseases. Content: More than 85,000 twin pairs born 1870-2008 in Denmark. Validity and coverage: Four main ascertainment methods have been...... employed. Completeness of ascertainment varies according to birth cohorts. For birth cohorts 1870-1930 both twins should survive to age 6 years. From 1931-1968 72% of all twin pairs has been ascertained, with complete ascertainment of all live born twins since 1968. CONCLUSION: Because twins have been...... identified independent of traits and on a population basis, the Danish Twin Registry is well suited for studies to understand the influence of genetic and environmental factors for a wide variety of diseases and traits....

  3. Conjoined Twins: A Worldwide Collaborative Epidemiological Study of the International Clearinghouse for Birth Defects Surveillance and Research

    Science.gov (United States)

    MUTCHINICK, OSVALDO M.; LUNA-MUÑOZ, LEONORA; AMAR, EMMANUELLE; BAKKER, MARIAN K.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; DUTRA, MARIA DA GRAÇA; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, BRIAN; MARENGO, LISA K.; MARTÍNEZ-FRÍAS, MARÍA-LUISA; MASTROIACOVO, PIERPAOLO; MÉTNEKI, JULIA; MORGAN, MARGERY; PIERINI, ANNA; RISSMAN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SIFFEL, CSABA; SZABOVA, ELENA; ARTEAGA-VÁZQUEZ, JAZMÍN

    2015-01-01

    Conjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. The process by which monozygotic twins do not fully separate but form CT is not well understood. The purpose of the present study was to analyze diverse epidemiological aspects of CT, including the different variables listed in the Introduction Section of this issue of the Journal. The study was made possible using the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) structure. This multicenter worldwide research includes the largest sample of CT ever studied. A total of 383 carefully reviewed sets of CT obtained from 26,138,837 births reported by 21 Clearinghouse Surveillance Programs (SP) were included in the analysis. Total prevalence was 1.47 per 100,000 births (95% CI: 1.32–1.62). Salient findings including an evident variation in prevalence among SPs: a marked variation in the type of pregnancy outcome, a similarity in the proportion of CT types among programs: a significant female predominance in CT: particularly of the thoracopagus type and a significant male predominance in parapagus and parasitic types: significant differences in prevalence by ethnicity and an apparent increasing prevalence trend in South American countries. No genetic, environmental or demographic significant associated factors were identified. Further work in epidemiology and molecular research is necessary to understand the etiology and pathogenesis involved in the development of this fascinating phenomenon of nature. PMID:22002822

  4. Monitoring and analysis of perinatal birth defect%围产儿出生缺陷的监测与分析

    Institute of Scientific and Technical Information of China (English)

    梁海丽; 陈源鸿; 王丽平; 蔡娟; 温新创

    2012-01-01

    Objective Analysis of epidemiology and influencing factors of perinatal birth defects from 2002 to 2010. Method The defect rate of perinatal birth and influencing factors were analyzed based on the birth defect surveillance data and the birth information from Nanshan Hospital, Guangdong Medical College. Results The birth defect rate was 15.88‰ over the period of nine years,and it was significantly increased since 2007.The death rate of defect birth accounted for 24.88% of the total perinatal death. The top birth defects were congenital heart disease, multi-fingered and jointed fingered, total cleft lip and palate, fetal edema syndrome, and neural tube malformations, accounted for 52.55% of total birth defects. The birth defect was related to residence origin of the parents, gender and number of the neonates, season of the birth, as well as pregnant times, delivery times, age and education levels of the pregnant women. Conclusion The control of birth defect is critical.Further investigations on the etiology of birth defect are needed to provide effective prevention and control strategies.Extensive health education and guidance on marriage and pregnancy, prenatal and post natal cares,and physical examination on neonates are the effective ways to reduce the rate of birth defects and increase the quality of population.%目的 分析2002-2010年围产儿出生缺陷流行病学特征及影响因素.方法 以2002-2010年广东医学院附属南山医院分娩信息及出生缺陷的监测资料为基础,对缺陷率及影响因素进行分析.结果 9年间出生缺陷率为15.88%,2007年后缺陷率明显增高;缺陷儿死亡占围产儿死亡的24.88%;前五位出生缺陷依次为先天性心脏病、多指+并指、总唇腭裂、胎儿水肿综合征、神经管畸形,共占畸形总数的52.55%;出生缺陷发生与户籍、性别、季节、胎数及产妇年龄、文化程度、孕次、产次有关.结论 出生缺陷防控形势严峻,应深入

  5. Characteristics of rural birth defects and intervention strategies%农村出生缺陷特征及干预对策临床研究分析

    Institute of Scientific and Technical Information of China (English)

    黄蓉; 杨妹; 陈娟文; 吴秋婵; 林怡

    2015-01-01

    目的:探讨我市农村出生缺陷的临床特征,为临床制订干预措施提供科学依据。方法:对我市农村出生缺陷的发生率和特征进行临床分析,与城市出生缺陷进行比较。结果:我市农村出生缺陷发生率为73.51/万,城乡出生缺陷发生率有显著差异,农村出生缺陷发生率比城市高近一倍,(P均<0.005),农村出生缺陷前三位依次为消化系统畸形、四肢畸形和神经系统畸形,分别占出生缺陷的28.39%、24.15%和11.86%。结论:我市农村出生缺陷发生率还处于较高水平,而且神经系统出生缺陷比较突出,主要原因是农村育龄妇女对口服叶酸预防出生缺陷等措施不理解、不接受,思想认识还未真正提高;基层围产保健水平低。我市农村人口占80%以上,因此,在制定出生缺陷干预对策时,应将重点放在影响人力资源与人民生活质量的病种和农村上。%Goal To investigate the clinical characteristics of birth defects in our city, and to provide scientific basis for clinical intervention. Methods the incidence and characteristics of birth defects in rural areas were analyzed, and compared with the urban birth defects. Finally The city rural birth defect rate 73.51/, urban and rural birth defect rate has the remarkable difference, rural incidence of birth defects rate nearly one times higher than that of urban, respectively (P<0.005). The rural birth defects in the former three followed by digestive system malformations, limb deformities and nervous system malformation, respectively, accounting for birth defects of 28.39%and 24.15%and 11.86%. Discussion our city rural birth defects incidence is still at a higher level and nervous system of birth defects is more outstanding, main reason is rural women of childbearing age oral folic acid to prevent birth defects and other measures do not understand, do not accept and ideas have not really improve;primary Wai care

  6. Advances in prenatal screening and prenatal diagnosis for birth defect%出生缺陷产前筛查及产前诊断研究进展

    Institute of Scientific and Technical Information of China (English)

    吴清明; 周瑾

    2011-01-01

    出生缺陷已成为世界婴儿死亡、儿童和成人残疾的主要原因之一,是目前全世界关注的一个重大公共卫生问题.出生缺陷由遗传因素、环境致畸因素或两者共同作用所致.我国是出生缺陷高发国家,通过早期诊断、早期干预可以避免至少70%出生缺陷.出生缺陷干预是一个系统工程,产前筛查和产前诊断是胎儿出生缺陷干预的有效手段,是出生缺陷干预二级预防中的重要组成部分.%Birth defects has been one of main causes of infant mortality, children and adult disability, and are becoming main public heath problem worldwide. Birth defects are associated with environmental factors, genetic factors or interactions of the genetic factors and environmental factors. It is high rates of birth defects in China, at least 70% of the birth defects can be avoided of early diagnosis is determined and early interventions are performed. Intervention of birth defects is a system process, prenatal screening and prenatal diagnosis are effective interventions, and they are the key components of the secondary prevention in birth defects control.

  7. Multivitamins, Folic Acid and Birth Defects: Knowledge, Beliefs and Behaviors of Hispanic Women in North Carolina

    Science.gov (United States)

    deRosset, Leslie; Mullenix, Amy; Zhang, Lei

    2009-01-01

    Background: Consumption of folic acid prior to conception can prevent up to 70% of neural tube defect (NTD)-affected pregnancies. In 1992, the U.S. Public Health Service (USPHS) issued a recommendation that all women of childbearing age capable of becoming pregnant consume 400 [mu]g of folic acid daily to reduce their risk for a NTD-affected…

  8. Birth Defects in Newborns: Spina Bifida Index at Rio Grande Do Norte State in Brazil

    Directory of Open Access Journals (Sweden)

    Arnaldo CM Junior

    2014-08-01

    Conclusion: Northeast region is the one that has the major incidence of SB in Brazil country, but RN state has a number lower than others states from its region. It was made an update about therapeutic options to minimize the morbidity and mortality in newborn with SB congenital defects. [J Interdiscipl Histopathol 2014; 2(4.000: 217-223

  9. Analysis on the the monitoring results of birth defect in Zhanjiang%湛江市出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    黎文清; 杨妹; 陈娟文; 叶婉华

    2011-01-01

    Objective: To explore the status and epidemiologic characteristics of birth defect in Zhanjiang, seek a more effective intervention countermeasure to reduce birth defect.Methods: According to the nation birth defect monitoring network and registration reporting requirement of monitoring plan in Zhanjiang, the monitoring data of birth defect eases in 2009 were analyzed retrospectively, then the resuits were analyzed by statistical method.Results: In 2009, 335 infants with birth defect were born in Zhanjiang, the incidence of birth defeet was 65.45/ten thousand, which was lower than that of the entire province, achieved the goal of child development plan in Guangdong province (90/ten thousand) But after cancelling compulsion pre -marital physical examination in 2003, the incidence of birth defect increased year by year, compared with the incidence of birth defect in 2003, the incidence of birth defect in 2006 increased by nearly 1/2 (P <0.01 ), after "two summaries" intermediate stage appraisal in 2006, the incidence of birth defect decreased.Conclusion: Although the incidence of birth defect in Zhanjiang is lower than the average levels in the nation and the entire province, but the prevention and control work is still stern.The government and the entire society should move together and complete the third - level prevention earnestly, which may be the basic measures to reduce the occurrence of birth defect.%目的:探讨湛江市出生缺陷现状和流行病学特征,寻找降低出生缺陷更有效的干预对策.方法:根据全国出生缺陷监测网及湛江市监测方案的登记报告要求,对2009年出生缺陷监测资料进行回顾性分析,结果采用统计学方法进行显著性检验.结果:2009年湛江市出生缺陷儿335例,出生缺陷发生率为65.45/万,较全省出生缺陷发生率低,达到广东省儿童发展规划的目标(90/万).但2003年湛江市取消强制婚检后,出生缺陷发生率逐年上升,2006

  10. Analysis of Selected Maternal Exposures and Non-Syndromic Atrioventricular Septal Defects in the National Birth Defects Prevention Study, 1997–2005

    Science.gov (United States)

    Patel, Sonali S.; Burns, Trudy L.; Botto, Lorenzo D.; Riehle-Colarusso, Tiffany J.; Lin, Angela E.; Shaw, Gary M.; Romitti, Paul A.

    2015-01-01

    Although the descriptive epidemiology of atrioventricular septal defects (AVSDs), a group of serious congenital heart defects (CHDs), has been recently reported, non-genetic risk factors have not been consistently identified. Using data (1997–2005) from the National Birth Defects Prevention Study, an ongoing multisite population-based case–control study, the association between selected non-genetic factors and non-syndromic AVSDs was examined. Data on periconceptional exposures to such factors were collected by telephone interview from 187 mothers of AVSD case infants and 6,703 mothers of unaffected infants. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated from logistic regression models. Mothers who reported cigarette smoking during the periconceptional period were more likely to have infants with AVSDs compared with non-smokers, independent of maternal age, periconceptional alcohol consumption, infant gestational age, family history of CHDs, and study site (aOR 1.5, 95% CI 1.1–2.4). The association was strongest in mothers who smoked more than 25 cigarettes/day. In addition, mothers with periconceptional passive smoke exposure were more likely to have infants with AVSDs than unexposed mothers, independent of maternal age, active periconceptional smoking, infant gestational age, and family history of CHDs (aOR 1.4, 95% CI 1.0–2.0). No associations were observed between AVSDs and maternal history of a urinary tract infection or pelvic inflammatory disease, maternal use of a wide variety of medications, maternal occupational exposure, parental drug use, or maternal alcohol consumption. If the results of this preliminary study can be replicated, minimizing maternal active and passive smoke exposure may decrease the incidence of AVSDs. PMID:22903798

  11. Specific Association of Teratogen and Toxicant Metals in Hair of Newborns with Congenital Birth Defects or Developmentally Premature Birth in a Cohort of Couples with Documented Parental Exposure to Military Attacks: Observational Study at Al Shifa Hospital, Gaza, Palestine

    Directory of Open Access Journals (Sweden)

    Paola Manduca

    2014-05-01

    Full Text Available This study was undertaken in Gaza, Palestine, in a cohort of babies born in 2011. Hair samples of newborns were analyzed for metal load by DRC-ICP-MS. We report specific level of contamination by teratogen/toxicants metals of newborn babies, environmentally unexposed, according to their phenotypes at birth: normal full term babies, birth defects or developmentally premature. The occurrence of birth defects was previously shown to be correlated in this cohort to documented exposure of parents to weapons containing metal contaminants, during attacks in 2009. We detect, in significantly higher amounts than in normal babies, different specific teratogen or toxicant elements, known weapons’ components, characteristic for each of birth defect or premature babies. This is the first attempt to our knowledge to directly link a phenotype at birth with the in utero presence of specific teratogen and/or toxicant metals in a cohort with known episodes of acute exposure of parents to environmental contamination by these same metals, in this case delivered by weaponry The babies were conceived 20–25 months after the major known parental exposure; the specific link of newborn phenotypes to war-remnant metal contaminants, suggests that mothers’ contamination persists in time, and that the exposure may have a long term effect.

  12. 10年围产儿出生缺陷调查研究%Investigation and analysis of perinatal birth defects during 10 years

    Institute of Scientific and Technical Information of China (English)

    管淑彩; 李敏; 刘青

    2012-01-01

    目的 探讨出生缺陷的状况及其影响因素,为降低出生缺陷干预措施的制定提供依据.方法 回顾性监测分析我院2001年1月至2010年12月10年间分娩的围产儿出生缺陷状况.结果 10年监测17 365例围产儿,其中出生缺陷儿205例,平均出生缺陷发生率为11.81‰,总体出生缺陷的年度发生率间无显著性差异(χ2=4.303,P=0.890>0.05),但2006年至2010年与2001年至2005年相比,神经管畸形的构成比明显下降(17.09%vs29.55%,χ2=4.474,P=0.034 0.05 ). But compared with the period of 2001-2005, the constituent ratio of neural tube defect at the period of 2006-2010 decreased significantly ( 17.09% vs 29. 55% ,χ2 = 4. 474,P = 0.034 <0.05,OR =0. 492 ). The first 5 types of birth defect were neural tube defect, polysyndactyly, cheilopalatognathus, urinary tract defect and congenital cardiopathy in turn, and the incidence rates of them were 2. 66 , 2.49 , 1. 22 , 1. 10 and 0. 98 , respectively. The sum of incidence of the first three types occupied 52. 69% of overall birth defect rate. The age of puerperants (x = 14. 946,P =0.000 <0. 05,OR = 1.712 ) and the gender of perinatal infants (χ2 = 6.488 ,P = 0. 011 <0. 05, OR = 1.440 ) were closely related with birth defect. There were 52. 20% of birth defect diagnosed before birth, and B-ultrasound was the main method for diagnosing ( 57. 07% ). Conclusion The incidence rate of birth defect in the area needs to be cut down, especially the types of neural tube defects, polysyndactyly and cheilopalatognathus. Low-dose of folic acid has significant effect in preventing neural tube defects.

  13. HETEROGENEITY OF NEURAL-TUBE DEFECTS IN EUROPE - THE SIGNIFICANCE OF SITE OF DEFECT AND PRESENCE OF OTHER MAJOR ANOMALIES IN RELATION TO GEOGRAPHIC DIFFERENCES IN PREVALENCE

    NARCIS (Netherlands)

    DOLK, H; DEWALS, P; GILLEROT, Y; LECHAT, MF; AYME, S; CORNEL, M; CUSCHIERI, A; GARNE, E; GOUJARD, J; LAURENCE, KM; LILLIS, D; LYS, F; NEVIN, N; OWENS, J; RADIC, A; STOLL, C; STONE, D; TENKATE, L

    1991-01-01

    In the period 1980-1987, neural tube defects were two to three times more prevalent in populations covered by EUROCAT registries in the United Kingdom and Ireland (UKI) than in Continental Europe and Malta (CEM). 1864 NTD cases in a total population of 580,000 births in UKI and 455 cases in a popula

  14. The Heart-Placenta Axis in the First Month of Pregnancy: Induction and Prevention of Cardiovascular Birth Defects

    Directory of Open Access Journals (Sweden)

    Kersti K. Linask

    2013-01-01

    Full Text Available Extrapolating from animal studies to human pregnancy, our studies showed that folate (FA deficiency as well as one-time exposure to environmental factors in the first two to three weeks of human gestation can result in severe congenital heart defects (CHDs. Considering that approximately 49% of pregnancies are unplanned, this period of pregnancy can be considered high-risk for cardiac, as well as for neural, birth defects, as the woman usually is not aware of her pregnancy and may not yet be taking precautionary actions to protect the developing embryo. Using avian and mouse vertebrate models, we demonstrated that FA supplementation prevents CHD induced by alcohol, lithium, or elevation of the metabolite homocysteine, a marker for FA deficiency. All three factors affected the important Wnt signaling pathway by suppressing Wnt-mediated gene expression in the heart fields, resulting in a delay of cardiomyocyte migration, cardiomyogenesis, and CHD. Optimal protection of cardiogenesis was observed to occur with FA supplementation provided upon morning after conception and at higher doses than the presently available in prenatal vitamin supplementation. Our studies demonstrate pathways and cell processes that are involved with protection of one-carbon metabolism during heart development.

  15. Sirenomelia : An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research, and Literature Review

    NARCIS (Netherlands)

    Orioli, Ieda M.; Amar, Emmanuelle; Arteaga-Vazquez, Jazmin; Bakker, Marian K.; Bianca, Sebastiano; Botto, Lorenzo D.; Clementi, Maurizio; Correa, Adolfo; Csaky-Szunyogh, Melinda; Leoncini, Emanuele; Li, Zhu; Lopez-Camelo, Jorge S.; Lowry, R. Brian; Marengo, Lisa; Martinez-Frias, Maria-Luisa; Mastroiacovo, Pierpaolo; Morgan, Margery; Pierini, Anna; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Castilla, Eduardo E.

    2011-01-01

    Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance system m

  16. RELIANCE ON GEOCODED MATERNAL RESIDENCE: IMPACT ON A POPULATION-BASED CASE-CONTROL STUDY OF AIR QUALITY AND BIRTH DEFECTS

    Science.gov (United States)

    Introduction: Unbiased geocoding of maternal residence is critical to the success of an ongoing population-based case-control study of exposure to five criteria air pollutants and the risk of selected birth defects in seven Texas counties between 1997 and 2000. The geocoded res...

  17. Birth Defects Among Children Born to Human Immunodeficiency Virus-Infected Women Pediatric AIDS Clinical Trials Protocols 219 and 219C

    NARCIS (Netherlands)

    Brogly, Susan B.; Abzug, Mark J.; Watts, D. Heather; Cunningham, Coleen K.; Williams, Paige L.; Oleske, James; Conway, Daniel; Sperling, Rhoda S.; Spiegel, Hans; Van Dyke, Russell B.

    2010-01-01

    Background: Some studies have detected associations between in utero antiretroviral therapy (ARV) exposure and birth defects but evidence is inconclusive. Methods: A total of 2202 human immunodeficiency virus (HIV)-exposed children enrolled in the Pediatric AIDS Clinical Trials Group 219 and 219 C p

  18. 梧州地区1529例出生缺陷儿监测分析%A monitoring analysis in 1529 birth-defect

    Institute of Scientific and Technical Information of China (English)

    施国栋; 陈永予

    2009-01-01

    Objective: To comprehend birth-defect condition and disposition in wuzhou city; to provid evidence and strategy that obviate and interfere birth-defect; Methods: we collect data of birth-defect of wuzhou city in 2001 ~2006 year. Result: we find 1529 birth-defect in six year. average birth-defect rate is 17.41‰; birth-defect: Schridde syndrome (3. 17‰) , cheilognathus and cleft palat (1.61‰), eqninovarus (1.51‰), hyperdactylia (1.46‰), limb shortening (1.31‰), ankylodactylia (1.21‰), congenital hydrocephalus (1.01‰), cbeilognathus (0.91‰), anencephaly (0. 55%0), hypospadia (0.40‰). Conclusions: birth-defect rate of wuzhou city is decrease year by year in 2001 ~ 2006 year; it is emphasis that health information, medical examination of before marriage,, antepartum Screen, antenatal diagnosis were pervasion.%目的 了解梧州市出生缺陷发生情况及分布特征,为出生缺陷的预防和干预提供依据和对策.方法 收集梧州市2001~2006年出生缺陷资料,对资料进行分析.结果 6年间共发现出生缺陷儿1529例,平均出生缺陷率为17.41‰,2006年前10位出生缺陷为:胎儿水肿综合征(3.17‰),唇裂合并腭裂(1.61‰),马蹄内翻足(1.51‰),多指(1.46‰),肢体短缩(1.31‰),并指(1.21‰),先天性脑积水(1.01‰),唇裂(0.91%O),无脑畸形(0.55‰),尿道下裂(0.40‰).结论 梧州市2001~2006年出生缺陷发生率呈逐年下降趋势,因此应继续加强卫生知识宣教和婚前医学检查、产前筛查及产前诊断,以预防和减少出生缺陷的发生.

  19. 基因组学在预防出生缺陷中的应用%Application of Genomic Technologies in the Prevention of Birth Defects

    Institute of Scientific and Technical Information of China (English)

    曹建军; 方锴; 杨焕明

    2013-01-01

    China is a country suffering from high rate, 5.6%, of birth defects. Birth defects as one of the most commom causes of infant death, has risen to the second cause of infant death in 2011 from the fourth in 2000. In 2011, 19.1%infant deaths were from birth defects. Genetic factor is one of the most important factors of birth defects. With the rapid development of genomics research and genetic testing platform, the genetic testing has been more widely used in the prevention of birth defects. In this paper, we discuss the application of genomic technologies, as well as its importance, in the prevention of birth defects as for the three levels′ system of birth defects prevention.%中国是出生缺陷的高发国,出生缺陷总发生率约为5.6%,出生缺陷在全国婴儿死因中的构成比顺位由2000年的第4位上升至2011年的第2位,达到19.1%。遗传因素是出生缺陷发生的一个重要原因,随着基因组学的研究进展以及基因检测平台的高速发展,使得基因检测在常见的染色体异常、新生儿代谢性疾病及单基因病等出生缺陷预防中的应用越来越广泛。以出生缺陷的三级预防体系为基础,探讨基因组学在其体系中的应用对完善中国出生缺陷的预防工作是非常重要的。

  20. Association between prenatal exposure to antiretroviral therapy and birth defects: an analysis of the French perinatal cohort study (ANRS CO1/CO11.

    Directory of Open Access Journals (Sweden)

    Jeanne Sibiude

    2014-04-01

    Full Text Available BACKGROUND: Antiretroviral therapy (ART has major benefits during pregnancy, both for maternal health and to prevent mother-to-child transmission of HIV. Safety issues, including teratogenic risk, need to be evaluated. We estimated the prevalence of birth defects in children born to HIV-infected women receiving ART during pregnancy, and assessed the independent association of birth defects with each antiretroviral (ARV drug used. METHODS AND FINDINGS: The French Perinatal Cohort prospectively enrolls HIV-infected women delivering in 90 centers throughout France. Children are followed by pediatricians until 2 y of age according to national guidelines. We included 13,124 live births between 1994 and 2010, among which, 42% (n = 5,388 were exposed to ART in the first trimester of pregnancy. Birth defects were studied using both European Surveillance of Congenital Anomalies (EUROCAT and Metropolitan Atlanta Congenital Defects Program (MACDP classifications; associations with ART were evaluated using univariate and multivariate logistic regressions. Correction for multiple comparisons was not performed because the analyses were based on hypotheses emanating from previous findings in the literature and the robustness of the findings of the current study. The prevalence of birth defects was 4.4% (95% CI 4.0%-4.7%, according to the EUROCAT classification. In multivariate analysis adjusting for other ARV drugs, maternal age, geographical origin, intravenous drug use, and type of maternity center, a significant association was found between exposure to zidovudine in the first trimester and congenital heart defects: 2.3% (74/3,267, adjusted odds ratio (AOR = 2.2 (95% CI 1.3-3.7, p = 0.003, absolute risk difference attributed to zidovudine +1.2% (95% CI +0.5; +1.9%. Didanosine and indinavir were associated with head and neck defects, respectively: 0.5%, AOR = 3.4 (95% CI 1.1-10.4, p = 0.04; 0.9%, AOR = 3.8 (95% CI 1.1-13.8, p = 0

  1. 如皋市出生缺陷病因与死亡原因分析%Analysis of the causes of birth defects and death in Rugao

    Institute of Scientific and Technical Information of China (English)

    丁燕; 顾建明; 陆平; 黄文美; 李鸿斌

    2013-01-01

    Objective To evaluate the causes of birth defects and death at present .Methods The data of birth defects from 2007 to 2012 were retrospectively analyzed and periodically compared .Results The incidence rate of birth defects was 6.04‰from 2007 to 2012, and the average annual decline rate was 0.21‰.The top ten causes of birth defects were cleft lip and cleft palate , polydactyly and syndactyly , congenital malformations of cardiac septa , talipes equinovarus , congenital stenosis and atresia of the colon , congenital absence atresia and stricture of (external) auditory canal, microtia, congenital hydrocephalus, hypospadias, and bifid spine.They accounted for 79.14% of the total number of birth defects , and the surface defects of musculoskeletal system and digestive system were the majority .The top ten causes of death of birth defects were congenital malformations of cardiac septa , cleft lip and cleft palate , other congenital malformations of heart, congenital hydrocephalus , congenital stenosis and atresia of the colon , other shortage deformities of brain , congenital diaphragmatic hernia, congenital hydronephrosis , gastroschisis, and spina bifida.They accounted for 76.58% of death cases of birth defects and 20.38%of birth defects.Among them diseases of circulatory system and nervous system were the majority .The perinatal mortality rate of birth defects was 1.45‰,and the infant mortality rate of birth defects was 0.74‰.Folic acid supplementary items could not reduce the incidence of neural tube malformation in Rugao obviously (χ2 =0.21,P>0.05).The incidence of birth defects in boys was higher than girls(χ2 =6.12,P<0.05), and that of maternal age ≥30 was higher(χ2 =6.87,P<0.05).Conclusion Increased incidence of birth defects has been corrected , and comprehensive intervention measures play a role .It is suggested that the monitor of birth defects in nervous system and circulatory system should be promoted to explore the relationship between the

  2. Analysis on monitoring results of 554 cases with birth defects%554例出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    黄彩练

    2011-01-01

    Objective; To understand the prevalence, change trend and related factors of birth defects in liuyang city, provide a basis for making intervening measures. Methods; According to the requirements of brochure of birth defect monitoring of Chinese, the fetuses and infants whose mothers lived in 37 villages, towns and streets (including natives or those who had lived in Liuyang city for more than one year) were monitored from October first, 2006, the monitoring time was from 28 gestational weeks to 42 days after birth. Results; The incidence of birth defects was 108.70 per ten thousand, the incidence of birth defects in rural areas was 114. 28 per ten thousand, which was significantly higher than that in urban areas (64. 58 per ten thousand) (X2 = 11. 68, P < 0.01) . The mortality of perinatal infants was 7.93%0, the mortality of perinatal infants with birth defects was 3. 55%0, accounting for 44. 80% , birth defect was a main cause of perinatal death. The top five birth defects were accessory auricle, polydactyly, congenital heart disease, cleft lip with or without cleft palate and talipes equinovarus. Conclusion: Health education should be carried out widely among the population of childbearing age, supplement of folic acid should be popularized, health care before pregnancy and during the first trimester of pregnancy should be enhanced, the factors inducing birth defects should be avoided, consultation about prepotency, prenatal examination and prenatal diagnosis should be conducted, all the a-bove - mentioned measures are effective to reduce the occurrence of birth defects.%目的:了解浏阳市出生缺陷的发生状况、变化趋势及相关因素,为制定干预措施提供依据。方法:按照《中国人群出生缺陷监测手册》要求,从2006年10月1日起对居住在浏阳市37个乡、镇、街道产妇(包括本地户口及非本地户口在浏阳市居住1年以上的产妇)的胎婴儿进行人群监测,监测期限为孕满28周~产后42天

  3. Prevalence Study of Birth Defects in the City of Panzhihua%攀枝花市出生缺陷的现况调查

    Institute of Scientific and Technical Information of China (English)

    徐永莲; 张方芳; 唐俊; 罗汝琼; 伍文霞; 张光艳

    2012-01-01

    Objective: To develop the prevention of birth defects and improve the quality of births from the prehension of the incidence, distribution characteristics, influencing factors and causes of birth defect, and institute implementation. Methods: Babies born between October 1st 2008 and September 30th 2011 were recorded according to the city monitoring program of birth defect. Results: There are totally 30 111 perinatal babies are observed and diagnosed. 381 babies with over twenty-eight weeks old were found birth defect. The rate of birth defect was 12.65 per thousand. To make a comparison between male and female, the difference have significant. Male incidence was statistical higher than female incidence (x2=ll.49,P〈0.01). There was no differences on birth defects mothers in all age groups. The main birth defect were cleft lips, ear deformity and multi finger toe in Panzhihua. Conclusion: The rate of birth defect decreased in near three years in Panzhihua. The keys of reduction lied in completely intervention measures on birth defects, three Prevention measures and enhanced health care during pregnancy.%目的:掌握攀枝花市出生缺陷发生率,了解出生缺陷分布特征、影响因素、发生原因等,制定预防出生缺陷实施方案,提高出生人口素质。方法:按照“攀枝花市出生缺陷监测方案”的要求,在攀枝花市所有出生缺陷监测单位对2008年10月1日至2011年9月30日出生的围产儿进行监测。结果:共监测30111例围产儿,胎龄28周以上出生缺陷381例,出生缺陷发生率为126.5/万;男性出生缺陷发生率高于女性,差异具有统计学意义(x2=11.49,P〈0.01);出生缺陷儿母亲各年龄组间差异无统计学意义。攀枝花市出生缺陷主要为总唇裂、多指(趾)、外耳畸形等。结论:攀枝花市三年来出生缺陷发生率呈下降趋势;全面实施出生缺陷干预措施,认真落实“三级预防”措施、

  4. Study on Birth Defect Intervention and Standardization Mode%出生缺陷干预及规范化模式的研究

    Institute of Scientific and Technical Information of China (English)

    刁文强; 幸惠云

    2015-01-01

    Objective:To study and explore the intervention of birth defects on the effect of themarried couples, in order to reduce the birth rate of birth defects, improve the comprehensive quality of the birth population reference.Method: 12 000 married couples in our region from June 2011 to May 2014 were selected as the research objects, and they were given birth defect intervention on its three. The first level intervention was to prevent the birth of children with birth defects, secondary interventions was to reduce the incidence of birth defects, three intervention was to treat children of birth defects. Interventions focus was on primary intervention to prevent birth defects in children born.District,town,village three level of division of labor,cooperation, for marriedcouples of childbearing age premarital examination,free eugenics propaganda and education,pre pregnancy virus and genetic disease detection, pre pregnancy and early pregnancytaking free pregnancy B ultrasound examination,Fu Shi Fu,regular follow-up.Result:Premarital education to carry out rate,pre-marital medical examination rate,pregnancy B-examination and regular follow-up of the number of persons in 2014 were significantly higher than those of 2013,2012 and 2011(P<0.05).Early pregnancy rates of four viruses tested positive for the virus (rubella virus,herpes virus, Toxoplasma gondii, cytomegalovirus), a genetic disease before pregnancy rate (thalassemia,G6PD deficiency) in 2014 were significantly higher than those of 2013, 2012 and 2011(P<0.05).And the number of women in early pregnancy taking Forceval was significantly higher than that of 2013,2012 and 2011.The birth defect rate in 2014 was significantly lower than that in 2013,2012,2011(P<0.05), the intensity was positively correlated with the level of intervention.Conclusion:For married women of childbearing age of birth defect intervention, especially the level of intervention, to the birth of children with birth defects play a preventive role

  5. Epidemiology of multiple congenital anomalies in Europe: A EUROCAT population-based registry study

    DEFF Research Database (Denmark)

    Calzolari, Elisa; Barisic, Ingeborg; Loane, Maria;

    2014-01-01

    more frequently prenatally diagnosed (p congenital heart defects...... and limb anomalies were the least likely to occur with other anomalies (13%) (p congenital heart defects were present in half of all MCA cases. Among males with MCA, the frequency of genital anomalies was significantly greater than the frequency of genital......BACKGROUND: This study describes the prevalence, associated anomalies, and demographic characteristics of cases of multiple congenital anomalies (MCA) in 19 population-based European registries (EUROCAT) covering 959,446 births in 2004 and 2010. METHODS: EUROCAT implemented a computer algorithm...

  6. 出生缺陷儿母亲心理健康状况调查研究%An investigation on psychological status of maternal of birth defects

    Institute of Scientific and Technical Information of China (English)

    黄广文; 杜其云; 刘智昱

    2012-01-01

    Objective To explore the psychological status of mother of birth defects so as to explore effective intervention strategy. Methods 595 maternal of birth defects and 1 249 maternal of no birth defects were included in the case-control study. General data questionnaire and Symptom Checklist 90 (SCL-90) were filled out by mother with or without birth defects. Results Scores of Somatization, Obsessive Symptom, Personal relations, Depression, Anxiety, Hostility, Terror, Paranoid ideal, Psychoticism of SCL-90 factors of mother of birth defects were significantly higher than that of mother without birth defects (both P0.05), scores of Terror factor among different age of mother of birth defects was significantly different (P0.05). Conclusions The psychological status of mother of birth defects are at low-level, we should pay more attention to interview with mother of birth defects.%目的 探讨出生缺陷儿母亲心理健康状况,为制定干预措施提供依据.方法 采用一般情况调查问卷及症状自评量表(SCL-90)对595例出生缺陷儿母亲及1 249例出生正常儿母亲进行调查评定.结果 SCL-90的9个因子中,出生缺陷儿母亲躯体化、强迫症状、人际关系、抑郁、焦虑、敌对、恐怖、偏执、精神病性因子分均明显高于出生正常儿母亲(均有P<0.01).出生缺陷儿母亲不同受教育程度之间SCL-90因子分比较差异均有统计学意义(均有P<0.05);不同职业之间SCL-90因子分比较,差异无统计学意义(均有P>0.05);不同年龄段之间SCL-90恐怖因子分比较,差异有统计学意义(P<0.01).城镇与农村出生缺陷儿母亲SCL-90因子分比较,差异无统计学意义(均有P>0.05).结论 出生缺陷儿母亲心理健康水平低,应加强出生缺陷儿母亲心理干预.

  7. Phocomelia: a worldwide descriptive epidemiologic study in a large series of cases from the International Clearinghouse for Birth Defects Surveillance and Research, and overview of the literature.

    Science.gov (United States)

    Bermejo-Sánchez, Eva; Cuevas, Lourdes; Amar, Emmanuelle; Bianca, Sebastiano; Bianchi, Fabrizio; Botto, Lorenzo D; Canfield, Mark A; Castilla, Eduardo E; Clementi, Maurizio; Cocchi, Guido; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R Brian; Mastroiacovo, Pierpaolo; Mutchinick, Osvaldo M; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Siffel, Csaba; Szabova, Elena; Martínez-Frías, María-Luisa

    2011-11-15

    Epidemiologic data on phocomelia are scarce. This study presents an epidemiologic analysis of the largest series of phocomelia cases known to date. Data were provided by 19 birth defect surveillance programs, all members of the International Clearinghouse for Birth Defects Surveillance and Research. Depending on the program, data corresponded to a period from 1968 through 2006. A total of 22,740,933 live births, stillbirths and, for some programs, elective terminations of pregnancy for fetal anomaly (ETOPFA) were monitored. After a detailed review of clinical data, only true phocomelia cases were included. Descriptive data are presented and additional analyses compared isolated cases with those with multiple congenital anomalies (MCA), excluding syndromes. We also briefly compared congenital anomalies associated with nonsyndromic phocomelia with those presented with amelia, another rare severe congenital limb defect. A total of 141 phocomelia cases registered gave an overall total prevalence of 0.62 per 100,000 births (95% confidence interval: 0.52-0.73). Three programs (Australia Victoria, South America ECLAMC, Italy North East) had significantly different prevalence estimates. Most cases (53.2%) had isolated phocomelia, while 9.9% had syndromes. Most nonsyndromic cases were monomelic (55.9%), with an excess of left (64.9%) and upper limb (64.9%) involvement. Most nonsyndromic cases (66.9%) were live births; most isolated cases (57.9%) weighed more than 2,499 g; most MCA (60.7%) weighed less than 2,500 g, and were more likely stillbirths (30.8%) or ETOPFA (15.4%) than isolated cases. The most common associated defects were musculoskeletal, cardiac, and intestinal. Epidemiological differences between phocomelia and amelia highlighted possible differences in their causes.

  8. Phocomelia: A Worldwide Descriptive Epidemiologic Study in a Large Series of Cases From the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature

    Science.gov (United States)

    Bermejo-Sánchez, Eva; Cuevas, Lourdes; Amar, Emmanuelle; Bianca, Sebastiano; Bianchi, Fabrizio; Botto, Lorenzo D.; Canfield, Mark A.; Castilla, Eduardo E.; Clementi, Maurizio; Cocchi, Guido; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Siffel, Csaba; Szabova, Elena; Martínez-Frías, María-Luisa

    2015-01-01

    Epidemiologic data on phocomelia are scarce. This study presents an epidemiologic analysis of the largest series of phocomelia cases known to date. Data were provided by 19 birth defect surveillance programs, all members of the International Clearinghouse for Birth Defects Surveillance and Research. Depending on the program, data corresponded to a period from 1968 through 2006. A total of 22,740,933 live births, stillbirths and, for some programs, elective terminations of pregnancy for fetal anomaly (ETOPFA) were monitored. After a detailed review of clinical data, only true phocomelia cases were included. Descriptive data are presented and additional analyses compared isolated cases with those with multiple congenital anomalies (MCA), excluding syndromes. We also briefly compared congenital anomalies associated with nonsyndromic phocomelia with those presented with amelia, another rare severe congenital limb defect. A total of 141 phocomelia cases registered gave an overall total prevalence of 0.62 per 100,000 births (95% confidence interval: 0.52–0.73). Three programs (Australia Victoria, South America ECLAMC, Italy North East) had significantly different prevalence estimates. Most cases (53.2%) had isolated phocomelia, while 9.9% had syndromes. Most nonsyndromic cases were monomelic (55.9%), with an excess of left (64.9%) and upper limb (64.9%) involvement. Most nonsyndromic cases (66.9%) were live births; most isolated cases (57.9%) weighed more than 2,499 g; most MCA (60.7%) weighed less than 2,500 g, and were more likely stillbirths (30.8%) or ETOPFA (15.4%) than isolated cases. The most common associated defects were musculoskeletal, cardiac, and intestinal. Epidemiological differences between phocomelia and amelia highlighted possible differences in their causes. PMID:22002800

  9. Rational Reflections about Euthanasia of Newborn with Birth Defect%对缺陷新生儿安乐死问题的理性思考

    Institute of Scientific and Technical Information of China (English)

    高华

    2012-01-01

    Currently, there is semi-open and hidden euthanasia of newborn with birth defects. Due to great family burden, social tolerance and the incomplete relevant legislation of birth defect, this phenomenon has existed for a long time. In order to avoid abuse, disordered and protect the interests of non-serious defects newborn, this article suggests that it should develop regulations as an important component of the birth defect intervention legislation.%分析目前我国存在着的半公开的、隐蔽的缺陷新生儿安乐死行为,因家庭负担、社会宽容态度和相关法律不完善致使该现象长期存在.当务之急是制定缺陷新生儿处置法规并将其作为整个出生缺陷干预立法的重要组成部分,以此来避免缺陷新生儿安乐死行为的滥用和无序,保障成千上万非严重缺陷新生儿的生命权益.

  10. A rapid evolution mechanism may contribute to changes in sex ratio, multiple birth incidence, frequency of auto-immune disease and frequency of birth defects in Clomid conceptions.

    Science.gov (United States)

    Fischer, K

    1990-01-01

    Under conditions favourable to the horizontal transmission of genetic material, a clomiphene isomer is hypothesized to encourage an alternate ovulatory route, with consequence for the sex ratio, multiple birth incidence, incidence of auto-immune disease, and frequency of malformations.

  11. Detection results of birth defects in 5,281 perinatal infants%5281例围产儿出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    陈燕玲; 黄惠萍; 卢伟棉

    2013-01-01

    目的 降低出生缺陷率,提高人口素质.方法 对2008年10月1日至2010年9月30日于本院分娩的5281例围产儿出生缺陷情况及其相关危险因素进行统计、分析,为开展出生缺陷的预防和干预提供依据.结果 3年来围产儿出生缺陷率平均为16.10‰,呈逐年上升趋势.先天性心脏病以及四肢骨骼肌肉系统缺陷为最常见的出生缺陷,分列1、2位.孕母年龄对围产儿出生缺陷有重要影响,>35岁组出生缺陷率明显高于其他各年龄组.出生缺陷的性别、产母居住地城乡差异均无统计学意义(P>0.05).结论 加强孕前、孕早期预防以及产前诊断,可减少出生缺陷的发生;需进一步加强胎儿心血管系统、四肢等超声产前检查;高龄孕妇孕中期应常规行产前诊断.%Objective To reduce the rate of birth defects and improve the quality of population.Methods Birth defects and its related risk factors were statistically analyzed in 5,281 perinatal infants who had been born in our hospital during the period of October 1,2008 to September 30,2010 so as to provide support for the prevention and intervention of birth defects.Results The rate of birth defects was 16.10 per thousand in the recent three years,with an increasing trend year by year.Congenital heart disease and defects of extremities musculoskeletal system were the most common birth defects,ranking the first and second place.Maternal age had an important impact on birth defects.Pregnant women aged >35 had a significantly higher rate of birth defects than those with different ages.No significant differences in sexes and both urban and rural areas were found.Conclusions Intensified prevention before pregnancy and in early pregnancy and strengthened prenatal diagnosis can reduce the incidence of birth defects.Prenatal ultrasonic examination for fetal cardiovascular system and limbs needs to be further strengthened.The women of advanced maternal age should receive routine

  12. 2008-2010年围产期出生缺陷分析%2008-2010 years perinatal birth defect analysis

    Institute of Scientific and Technical Information of China (English)

    景丽丽

    2011-01-01

    Objective: in order to know the QingShanOu incidence of birth defects, this paper discusses the related factors birth defects happen for formulating and take measures to provide the basis. Methods: according to the national birth defects monitoring scheme, at the request of (2008-2010) on October 1, 2007-October 31, 2010 QingShanOu 5 home delivery hospital inpatient delivery at full and thoughtful within 7 days after perinatal infants dead for monitoring. Results: three years were monitoring perinatal infants dead 11 850 cases, birth defects in 104 cases, de- fect rate of 8.8%, which was born in 2008 to 3.6 per 2009, defects in 10.1%~, in 2010 to 13.2 per thousand. Birth defects increasing year by year, the top five birth defects is as follows: (1) the outer ear malformation; (2) by and means; Cleft palate (3); (4) foot deformity; (5) head facial deformity. Mother from air pollution in the area close to significantly higher than the far from air pollution area, mother of low degree of culture birth defects son is obviously higher than that of the culture degree is high. The occurrence of the birth defects and gender no phase relationship. Conclusion: to widely develop health education, general knowledge level of eugenic and superior nurture, strengthen the examination before marriage, prenatal care and prenatal diagnosis work.%目的:了解青山区出生缺陷发生率,探讨出生缺陷发生的相关因素,为制定和采取预防干预措施提供依据。方法:按照全国出生缺陷监测方案的要求,对(2008-2010年)2007年10月1日-2010年10月31日青山区5家分娩医院住院分娩的孕满28周到产后7天内围产儿进行监测。结果:3年共监测围产儿11850例,出生缺陷儿104例,缺陷发生率为8.8%,其中2008年出生缺陷率为3.6%。、2009年为10.1%。、2010年为13.2%。。出生缺陷呈逐年上升趋势,前5位出生缺陷依次为:①外耳畸

  13. 武汉市出生缺陷相关因素分析%Analysis on the related factors of birth defect in Wuhan city

    Institute of Scientific and Technical Information of China (English)

    张斌; 杨蓉; 刘明珠; 刘艳; 胡荣华; 杜玉开

    2011-01-01

    Objective; To understand the current situation of birth defect in Wuhan city from 2008 to 2010, explore the related effect factors of birth defect, provide a basis for further study. Methods; The data of birth defect were collected from 11 obstetrical institutions in Wuhan, 933 infants with birth defect were selected as case group, 933 lying - in women who gave birth to normal neonates from 2008 to 2010 were selected from Wuhan MCH information system as control group, the related data were obtained according to report cards of birth defect and MCH information system, then statistical analysis was performed. Results; The incidence of birth defect in Wuhan city from 2008 to 2010 was 17.77% , the incidence of birth defect in remote urban area was significantly higher than that in central urban area ( P <0.01); the incidence of birth defect among the lying - in women less than 25 years, equal to and more than 35 years were significantly higher than that among the lying - in women aged 25 ~35 years old (P <0.01) ; 11 factors, such as gravida, fetal gender, being ill during the first trimester of pregnancy, were used as independent variables for logistic regression analysis, the result showed that permanent address during pregnancy, being ill during the first trimester of pregnancy and spontaneous abortion history were included into the modeL Living in remote urban area, viral infection and hyperemesis gravidarum during the first trimester of pregnancy, spontaneous abortion history ( more than two times) increased the risk of birth defect. Conclusion; Primary prevention of birth defect should be paid more attention to, large - scale case - control study based on population should be carried out, and the epidemiological factors of birth defect should be understood, in order to a-dopt corresponding interventional measures and reduce the occurrence of birth defect.%目的:了解2008~2010年武汉市出生缺陷发生的情况,弄清对出生缺陷发生有影响的相关

  14. Epidemiologic characteristics of birth defects in Shaanxi province in 2010%陕西省2010年出生缺陷流行特征分析

    Institute of Scientific and Technical Information of China (English)

    吴小琴; 李盘; 周晓娟; 杨杨

    2012-01-01

    [目的]了解陕西省目前的出生缺陷发生水平及流行特征,为进一步探讨影响该省出生缺陷发生的危险因素提供科学依据. [方法]按照中国出生缺陷监测方案,对2010年度陕西省25家监测医院出生的孕28周至生后7d所有围产儿进行出生缺陷监测,采用Excel 2003软件进行数据录入,SPSS 13.0软件进行统计学分析. [结果]2010年陕西省医院监测的出生缺陷发生率为124.1/万,前五位出生缺陷依次为:先天性心脏病(16.4/万)、总唇裂(13.3/万)、神经管缺陷(13.1/万)、多指(趾)(11.3/万)、脑积水(5.1/万).农村的出生缺陷发生率高于城镇(x2=8.58,P<0.01).出生缺陷发生率无性别分布差异.母亲年龄≥35岁的缺陷发生率最高(170.5/万).双胎及以上的围产儿缺陷发生率明显高于单胎儿. [结论]陕西省2010年出生缺陷发生率低于全国同期水平,该省出生缺陷的分布具有明显的城乡、母亲年龄及胎数差异.政府部门应重视神经管缺陷在农村地区的一级预防工作,并针对高龄及多胎妊娠产妇采取有效预防措施.%[Objective] To investigate the incidence and epidemiologic characteristics of birth defects in Shaanxi province, and then to provide scientific evidences for exploring risk factors further. (Methods] According to "The Birth Defects Monitoring Program of China", all perinatal infants aged from 28 weeks of gestation to 7 days after birth in 25 monitoring hospitals in Shaanxi province in 2010 were monitored for birth defects, the data were entered by Excel 2003 and analyzed by SPSS 13. 0 software. [Results] The incidence of birth defects in Shaanxi province in 2010 was 124. 1/104 .The top five main birth defects were congenital heart diseases, total cleft lip, neural tube defects, polydactyly,congenital hydrocephalus, respectively,The incidence of birth defects in rural areas was significantly higher than that in urban areas (xz = 8. 58, P< 0. 01). There were no

  15. Monitoring analysis of birth defects from 2009 to 2010 in Guangzhou%广州市2009至2010年出生缺陷监测分析

    Institute of Scientific and Technical Information of China (English)

    邹兴文; 王平; 杨丽

    2011-01-01

    目的 探讨广州市2009至2010年出生缺陷发生率、发生类型、转归及影响因素.方法 收集并分析广州市全部148家医院在2009至2010年期间分娩儿出生缺陷监测资料.结果 共监测352 084例围产儿,发生出生缺陷5 724例,出生缺陷发生率162.6/万,前五位缺陷类型依次是先天性心脏病、多指(趾)、总唇腭裂、马蹄内翻足和外耳其他畸形.男性围产儿的出生缺陷发生率高于女性(177.74/万 vs 144.66/万,P<0.05),早产儿的出生缺陷发生率高于足月儿(756.40/万 vs 122.19/万,P<0.05),孕母年龄越大,发生出生缺陷的风险越高(P<0.05).严重出生缺陷的治疗性引产率超过60%.结论 广州市出生缺陷发生率偏高,应重视对男婴、早产儿的先天畸形检查,加强对高龄孕妇的管理.提高产前确诊率和致死性畸形的治疗性引产率.%Objective To explore the incidence, type, outcomes and influencing factors of birth defects in Guangzhou from 2009 to 2010. Methods The data of birth defects during this period from all of 148 hospitals in Guangzhou was collected and analyzed. Results Among 352 084 perinatal infants monitored, 5724 cases were detected with birth defects with incidence of 162. 6 per ten thousand. The first five birth defects were congenital heart disease, polydactylia, total cheiloschisis/palatoschisis, congenital talipes equino varus and deformity of external ear in order. The incidence of birth defects in boys was higher than that in girls (177. 74/ten thousand vs 144. 66/ten thousand, P < 0. 05 ), and it was higher in premature infants than term infants ( 756. 40/ten thousand vs 122. 19/ten thousand, P < 0. 05 ). The older the pregnant women were, the greater the risk of birth defects was. The rate of therapeutic termination of severe birth defects was more than 60%. Conclusion The incidence of birth defects is slightly high in Guangzhou. Attention should be paid to malformation examination on male infants and

  16. Craniofacial Birth Defects: The Role of Neural Crest Cells in the Etiology and Pathogenesis of Treacher Collins Syndrome and the Potential for Prevention

    OpenAIRE

    2010-01-01

    Of all the babies born with birth defects, approximately one-third display anomalies of the head and face [Gorlin et al., 1990] including cleft lip, cleft palate, small or absent facial and skull bones and improperly formed nose, eyes, ears, and teeth. Craniofacial disorders are a primary cause of infant mortality and have serious lifetime functional, esthetic, and social consequences that are devastating to both children and parents alike. Comprehensive surgery, dental care, psychological co...

  17. Study on the Secondary Prevention Strategy for Birth Defects%出生缺陷二级预防策略的研究

    Institute of Scientific and Technical Information of China (English)

    宋桂荣; 肖绪武; 孙瑾; 刘启贵

    2013-01-01

    Objective:To evaluate and compare the economic effectiveness of three strategies of the sec-ondary prevention for birth defects in order to provide the basis for the prevention decision on congenital disa-bilities .Methods:A decision tree model was used to make a decision analysis on the cost-effectiveness of the three strategies .Results :The birth defects detection rates of three strategies were 82 .82% ,98 .2% ,94 . 50% respectively .The cost of one birth defect detected of the third strategy was lowest .Conclusions :In-creasing an ultrasound screening for high-risk pregnant women is an economical and effective strategy to pre-vent birth defects .%目的:评价、比较出生缺陷的3种二级预防策略的经济学效果,为有效预防先天性残疾提供决策依据。方法:采用决策树模型,对3种策略的成本-效果进行比较。结果:3种策略的出生缺陷检出率分别为82.82%、98.2%、94.50%,策略3成本/效果比最低。结论:高危孕妇增加超声筛查是一种既经济又有效的预防策略。

  18. Research Progress of Factors Related to Birth Defect%出生缺陷相关因素的研究进展

    Institute of Scientific and Technical Information of China (English)

    梅盛平; 张红

    2011-01-01

    It is a basic national policy to control the size of the population and improve its quality in China,but birth defect is an important factor that affects the population quality.This paper summarizes the occurrence,classification,etiology,pathogenesis of birth defects and explores birth defect surveillance,intervention and prevention work so as to lay the foundation for improving population quality and protecting people’s health.%控制人口数量,提高人口素质是我国的一项基本国策,而出生缺陷则是严重影响人口素质的一个重要因素。文章综述出生缺陷的发生、分类、发病因素、发病机制,探讨我国出生缺陷的监测、干预和预防工作的开展,为提高人口素质,保护人群健康打下基础。

  19. Birth defects in Shandong, China, 2007-2010%山东省2007-2010年人群出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    周凤荣; 张蓬; 范媛媛; 陈志欣; 郝宝珍

    2011-01-01

    目的 了解山东省人群出生缺陷发生情况,为今后监测工作的管理重点和制定出生缺陷预防措施提供依据.方法 对2007——2010年山东省人群出生缺陷监测的数据进行率及顺位等分析.应用Visual FoxPro 6.0建立数据库,采用SPSS 15.0软件进行数据分析.结果 2007——2010年人群出生缺陷发生率分别为107.44/万、82.86/万、141.29/万和124.64/万,年度间人群出生缺陷发生率比较差异有统计学意义(P<0.01);人群出生缺陷发生率顺位从高到低依次为先天性心脏病、多指(趾)、总唇裂、脑积水、神经管缺陷、肢体短缩等.结论 山东省人群出生缺陷发生率在逐年上升,男性高于女性;出生缺陷先天性心脏病居首位,有逐年上升趋势.%Objective To analyze the occurrence of birth defects based on clinical outcomes of new born babies in Shandong province and provide scientific basis for early diagnosis and intervention. Methods The records of birth defects were collected for the year of 2007-2010. Visual FoxPro6. 0 was applied to set up a database and SPSS15. 0 was used for statistical analysis. Results The prevalence rates of birth defects were 107. 44, 82. 86, 141. 29 and 124. 64 per ten thousand newborns for the year of 2007-2010, repectively. The highest prevalence rate of birth defect was congenital heart disease (41. 06/10 000), followed by polydactyly (11. 41/10 0000), total cleftlip (11. 26/10 000), hydro-cephalus (8. 41/10 000) , neural tube defects (6. 84/10 000), limb reduction (3. 99/10 000) , and etc. There was higher frequency of birth defects in male babies (125. 68/10 000) than in female babies (98. 63/10 000). Conclusion Congenital heart disease is the most important birth defect. Maternal exam should include birth defect screening.

  20. 64例出生缺陷儿监测情况分析%Analysis of the outcome of 64 children born with birth defects

    Institute of Scientific and Technical Information of China (English)

    王香丽; 贾旭艳; 杨文方; 豆静

    2011-01-01

    Objective To analyze various related factors of birth defects so as to provide evidence for early prevention and reduce the rate of birth defects by monitoring the information of birth defect infants delivered or delivered with induction in our hospital during five years from 2006 to 2010. Methods The data of birth defect infants delivered in the hospital during these five years was retrospectively analyzed. Results There were 8215 cases of induction delivery and childbirth, 64 cases of which were birth defect infants. The average rate of birth defects was 7. 8‰. The top five types in the 64 cases were spina bifida ( 15. 6% ), hydrocephalus ( 14. 0% ), cleft lip ( 10.9% ), abnormal fingers and toes ( 9. 4% ) and cleft lip with cleft palate ( 7. 8% ) in turn. Analysis results indicated that the time when pregnancy started was related to birth defects. When pregnancy started in January, June or May, the rate of birth defects was higher than that in other months (x2 =5. 107, P < 0. 05 ), and the birth defects accounted up 48. 4% of all. Among the defect infants, males were more than females. The infants whose mothers lived in countryside and had poor education had higher birth defect rate. Conclusion Enhancing education on prepotency especially to married women in poor areas, picking pregnancy time, administering folic acid reasonably before pregnancy, establishing and perfecting primary prevention system, strengthening training for type-B ultrasonic physicians and clinicians, or improving prenatal monitoring and diagnosing technology is beneficial to prophylaxis of birth defects.%目的 通过监测西安交通大学医学院第一附属医院2006~2010年住院引产及分娩的出生缺陷婴儿情况,分析引起出生缺陷的各类相关因素,为早期预防并进一步降低出生缺陷率提供依据.方法 回顾性分析2006~2010年西安交通大学医学院第一附属医院的出生缺陷儿病例.结果 5年内共引产及分娩8 215

  1. Birth Defects Diagnosis

    Science.gov (United States)

    ... quad screen tests the levels of 4 proteins AFP (alpha-fetoprotein), hCG, estriol, and inhibin-A. Generally, ... of the proteins for which an amniocentesis tests. AFP AFP stands for alpha-fetoprotein, a protein the ...

  2. Preventing Birth Defects

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    NERVIDUCT malformation caught the attention of the Chinese government in 1983 when professor Yan Renying, now director of the China Maternal and Infant Health Care Center, conducted an epidemiological survey of new-borns in Shunyi County, Beijing, and discovered that one-third of infant mortality in the area was caused by

  3. Birth Defects: Cerebral Palsy

    Science.gov (United States)

    ... to help relax muscle spasms, including: Diazepam (Valium®), baclofen (Lioresal®), dantrolene (Dantrium®) and tizanidine (Zanaflex®). Your child takes these by mouth. Baclofen, a medicine that your child gets through a ...

  4. Surveillance of birth defects: Brazil and the US Vigilância epidemiológica em anomalias congênitas: Brasil e Estados Unidos

    Directory of Open Access Journals (Sweden)

    Daniela Varela Luquetti

    2011-01-01

    Full Text Available The impacts of birth defects in the society have substantially increased over the last decades in countries where the reduction of infant mortality by other causes has occurred. Birth defects surveillance represents an important source of information for planning X health policies and resource allocation. In this article, we discuss the potential utilizations, methodology options, limitations, and policy issues related to birth defects surveillance. Also, the birth defects surveillance programs from US and Brazil are described and compared as an illustration of the development of surveillance systems in two countries with clearly dissimilar health systems and resource allocation for birth defects programs. Finally, we propose measures for the improvement of the existing systems in both countries focusing at the utilization of preexisting resources.O impacto das anomalias congênitas na sociedade vem aumentando substancialmente nas últimas décadas nos países onde ocorreu a diminuição da mortalidade infantil por outras causas. A vigilância epidemiológica em anomalias congênitas representa uma importante fonte de informação para o planejamento de políticas de saúde e alocação de recursos. Neste artigo, os potenciais usos, opções de metodologia, limitações e questões de políticas de saúde relacionadas à vigilância epidemiológica em anomalias congênitas são abordados. Além disso, os programas dos Estados Unidos e Brasil são descritos e comparados para ilustrar sistemas em dois países com sistemas de saúde e alocação de recursos para as anomalias congênitas claramente diferentes. Finalmente, apresentamos propostas de medidas para melhorar os sistemas existentes em ambos os países, focalizando na utilização de recursos pré-existentes.

  5. U.S. Centers for Disease Control and Prevention and Environmental Protection Agency Urge Commonwealth of Puerto Rico to Consider Aerial Spraying as Part of Integrated Mosquito Control to Reduce Zika-Associated Birth Defects

    Science.gov (United States)

    EPA News Release: U.S. Centers for Disease Control and Prevention and Environmental Protection Agency Urge Commonwealth of Puerto Rico to Consider Aerial Spraying as Part of Integrated Mosquito Control to Reduce Zika-Associated Birth Defects

  6. Atenção aos defeitos congênitos no Brasil: panorama atual Birth defects and health strategies in Brazil: an overview

    Directory of Open Access Journals (Sweden)

    Dafne Dain Gandelman Horovitz

    2005-08-01

    Full Text Available O impacto dos defeitos congênitos no Brasil vem aumentando progressivamente, tendo passado da quinta para a segunda causa dos óbitos em menores de um ano entre 1980 e 2000, apontando para a necessidade de estratégias específicas na política de saúde. Foram localizadas, no Brasil, direcionadas aos defeitos congênitos, ações governamentais e não-governamentais. Estas envolvem serviços de informação sobre agentes teratogênicos na gravidez e sobre doenças metabólicas geneticamente determinadas, monitorização de defeitos congênitos, programa de triagem neonatal e tratamento de algumas doenças genéticas, imunização contra rubéola, além da fortificação de farinhas com ácido fólico como ação preventiva de certos defeitos congênitos. Apesar da importância de tais iniciativas, é pouco provável que seja possível atender à questão dos defeitos congênitos de forma integrada. Para a efetivação de um sistema de atenção voltado aos defeitos congênitos, deverá ser formulada política específica, de âmbito nacional, com a participação ativa do Ministério da Saúde, utilizando, como espinha dorsal, os serviços de genética existentes. Só assim, será possível a estruturação de uma rede regionalizada, hierarquizada e funcional voltada à atenção aos defeitos congênitos no Brasil.Birth defects have increased progressively in Brazil, shifting from the fifth to the second cause of infant mortality from 1980 to 2000, thus highlighting the need for specific health policy strategies. Some governmental and nongovernmental actions related to birth defects in Brazil include information services on teratogenic agents and inborn errors of metabolism, monitoring of birth defects, neonatal screening and treatment of some genetic diseases, and rubella immunization. In addition, flour fortification with folic acid for prevention of certain birth defects has begun recently. Despite the importance of such initiatives, it is

  7. Maternal alcohol drinking pattern during pregnancy and the risk for an offspring with an isolated congenital heart defect and in particular a ventricular septal defect or an atrial septal defect

    DEFF Research Database (Denmark)

    Strandberg-Larsen, Katrine; Skov-Ettrup, Lise Skrubbeltrang; Grønbaek, Morten;

    2011-01-01

    BACKGROUND: This cohort study examines the possible association between maternal alcohol intake, including binge drinking, during pregnancy, and the subsequent risk of having a child with an isolated congenital heart defect and, more specifically, with the isolated form of ventricular septal defect...... of alcohol. Few (if any) women with an excessive/abusive intake of alcohol were enrolled into the Danish National Birth Cohort. RESULTS: Through linkage with the National Hospital Discharge Registry, we identified 477 infants with a diagnosis of isolated congenital heart defect registered at any time during...... (VSD) or of an atrial septal defect (ASD). METHODS: Participants were 80,346 pregnant women who were enrolled into the Danish National Birth Cohort in 1996-2002 and gave birth to a live-born singleton without any chromosome anomalies. Twice during pregnancy these women were asked about their intake...

  8. 新疆多民族地区出生缺陷分析%Analysis of birth defects in Xinjiang multi-ethnic region

    Institute of Scientific and Technical Information of China (English)

    钱若筠; 刘红; 钟南; 王瑞; 邹红云; 何江; 余伍忠

    2011-01-01

    背景:新疆是一个多民族聚居的省区,地理位置不同,经济条件、气候环境等差异较大.目的:了解新疆不同民族出生缺陷发生发展趋势、病种及民族和地区差异.方法:根据新疆特殊的民族、地理条件及经济状况,按随机分层整群抽样方法,确定13个县(市)作为监测点,使用填报和.出生缺陷的诊断采用ICD10诊断标准.对2005-01/2008-12 4年间出生缺陷发生率进行统计,并分析出生缺陷的病种及其在各民族、地区的分布情况.结果与结论:新疆地区出生缺陷的平均发生率为97.43/万,4年间出生缺陷发生率表现为2006年较上一年度显著降低后,随之又逐年上升.出生缺陷发生率农村高于城市,男性多于女性,天山以南地区高于天山以北、以东及乌鲁木齐地区.在新疆的主要民族中,出生缺陷发生率以锡伯族和维吾尔族最高,满族和哈萨克族次之,汉族最低.4年间满族、蒙古族、回族出生缺陷发生率逐年下降,维吾尔族、汉族和哈萨克族有较小波动;但锡伯族却经历了一次大起大落的变化.出生缺陷病种前5位依次为神经管畸形、总唇裂、无脑畸形、先天性脑积水、唇裂合并腭裂.从分析结果可以看出新疆地区出生缺陷的发生存在民族和地理差异.%BACKGROUND: Xinjiang is a multi-ethnic region with significant differences in local geographical position, economic development and climatic environment. OBJECTIVE: To analyze the occurrence and development tendency of birth defects, disease categories and disparity among different ethnic groups and regions in Xinjiang.METHODS: A stratified cluster random sampling observation was performed in 13 counties (cities) according to the status of ethnical distribution and local economics of Xinjiang. Quarter Report Sheet on Babies and The defect babies register card were filled as the scheme of Chinese birth defect monitoring, and ICD10 diagnostic code was adopted in

  9. Clinical Analysis in 265 Perinatals Birth Defects%265例出生缺陷儿的临床分析

    Institute of Scientific and Technical Information of China (English)

    董红霞

    2012-01-01

      Objective To characterize the distribution patterns of birth defects in Huai-rou First Hospital 2006-2011. Methods Birth defects surveillance data in the period of January 2002 to December 2004 were analyzed. Results The overall prevalence rate of birth defects was 207.97/10,000 births. The first 5 common birth defects were hyperdactylism and ankylodactylia, accessory auricle,congenital heart disease,total cleft lip and palate,pigmented mole. chromosomal abnormalities,and neural tube defects. Conclusion To disease the prevalence rate of birth defects and elevate the disposition of the birth population, we should put the emphasis to preservation(the third-level prevention).%  目的 分析我院住院分娩围生儿的出生缺陷发生情况、变化趋势,为进一步预防出生缺陷的发生提供依据.方法 对2006至2011年在怀柔区第一医院住院分娩的围生儿出生缺陷监测资料进行分析.结果 6年共监测围生儿12742例,发现缺陷儿265例,平均出生缺陷发生率为207.97/万,前5位分别是多指(趾)及并指(趾)36例,副耳34例,先天性心脏病33例,唇裂合并腭裂23例,色素痣13例.结论 减少出生缺陷的工作重点在预防,应加强优生知识的宣传,提高产前检查质量及产前诊断技术,做好三级预防工作,以期降低围生儿出生缺陷的出生率,提高出生人口素质.

  10. Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature

    Science.gov (United States)

    SIFFEL, CSABA; CORREA, ADOLFO; AMAR, EMMANUELLE; BAKKER, MARIAN K.; BERMEJO-SÁNCHEZ, EVA; BIANCA, SEBASTIANO; CASTILLA, EDUARDO E.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; CSÁKY-SZUNYOGH, MELINDA; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, R. BRIAN; MARENGO, LISA K.; MASTROIACOVO, PIERPAOLO; MORGAN, MARGERY; MUTCHINICK, OSVALDO M.; PIERINI, ANNA; RISSMANN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SZABOVA, ELENA; OLNEY, RICHARD S.

    2015-01-01

    Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention. PMID:22002949

  11. 2010年常州市围产儿出生缺陷及城市功能区出生缺陷状况%Birth defects of perinatal infants in Changzhou city in 2010 and birth defects in different functional areas of the city

    Institute of Scientific and Technical Information of China (English)

    缪金剑; 周华; 蒋健

    2012-01-01

    Objective: To understand the birth defects in Changzhou city in 2010 and the birth defects in different functional areas of the city, explore the related factors of occurrence of birth defects in Changzhou city. Methods: The perinatal infants with birth defects who were bom in obstetric department of all the hospitals in Changzhou city in 2010 were collected, and the city was divided into central urban area, industrial area, and agricultural area according to the functions of the city, the birth defects of perinatal infants were compared among different functional areas. Results: There were 39 399 perinatal infants in 2010, the incidence of birth defects was 5.10‰, the incidence of birth defects and the top three birth defects were in accord with those from 2007 to 2009, the mean incidence of birth defects in Changzhou city was 5.10‰, and the incidences of birth defects in industrial area, central urban area, and agricultural area were 9.13‰, 4.60‰, and 3. 24‰, respectively, the incidence of birth defects in industrial area was significantly higher than the mean level in Changzhou city. Among the perinatal infants with birth defects, the indexes including floating population, gestational smoking or passive smoking, drinking during pregnancy, engaging in high risk works were higher than those of normal control group; the rate of medical examination before marriage and the regular examination rate during gestational period were lower than those in normal control group. Conclusion: Premarital check - up and pregestational health care should be enhanced, the management of reproductive health of the floating population should be improved, and the prenatal examination rate of birth defects should be strengthened, the measures above - mentioned can be conducted to reduce the incidence of birth defects.%目的:了解常州市2010年出生缺陷发生情况以及城市功能区出生缺陷状况,探讨常州市出生缺陷发生的相关因素.方法:收集2010

  12. 奉贤区13266例围产儿出生缺陷分析%Analysis on 13 266 perinatal infants with birth defects in Fengxian district

    Institute of Scientific and Technical Information of China (English)

    顾维红

    2011-01-01

    目的:了解奉贤区出生缺陷发生情况、分布特征、影响因素,为降低出生缺陷发生制定干预措施提供依据.方法:采用回顾性方法对2008年1月1日~2009年12月31日奉贤区13 266例监测围产儿进行分析.结果:①奉贤区两年间出生缺陷儿188例,出生缺陷率为14.17%;②出生缺陷前5位分别是先天性心脏病、多指(趾)、总唇裂、血管瘤和神经管畸形;③出生缺陷发生在男女性别、户籍、出生时间方面差异无统计学意义,但与孕妇年龄有关(x2=7.517,P<0.05);④出生缺陷儿死亡与非出生缺陷儿死亡差异有统计学意义(x2=1 345.85,P<0.001);⑤产前诊断及治疗性终止妊娠可降低活产婴儿的出生缺陷发生率,并使出生缺陷顺位发生改变.结论:出生缺陷发生与孕妇年龄有关,与性别、受孕时间、户籍无关;出生缺陷儿死亡是围产儿死亡的主要原因;做好三级预防是降低出生缺陷发生,降低围产儿死亡率的重要措施.%Objective: To understand the occurrence, distribution characteristics and effect factors of birth defects in Fengxian distriet, provide a basis for making intervention measures to reduce the occurrence of birth defects. Methods: A retrospective method was adopted to analyze 13 266 perinatal infants in Fengxian district from January 1,2008 to December 31,2009. Results: From 2008 to 2009,188 perinatal infants with birth defects were born in Fengxian district, the incidence of birth defects was 14. 17‰; the first five birth defects were congenital heart disease, polydaetylism, total cleft lip, hemangioma and neural tube defect; there was no significant difference in incidences of birth defects between the perinatal infants with different genders, census registers and times of birth, but the incidences of birth defects were related to maternal age (x2 = 7. 517, P < 0. 05 ); there was significant difference in perinatal mortality between the perinatal infants with birth

  13. Clinical Case Registries (CCR)

    Data.gov (United States)

    Department of Veterans Affairs — The Clinical Case Registries (CCR) replaced the former Immunology Case Registry and the Hepatitis C Case Registry with local and national databases. The CCR:HIV and...

  14. Stroke Trials Registry

    Science.gov (United States)

    ... News About Neurology Image Library Search The Internet Stroke Center Trials Registry Clinical Trials Interventions Conditions Sponsors ... a clinical trial near you Welcome to the Stroke Trials Registry Our registry of clinical trials in ...

  15. 出生缺陷影响因素的病例对照研究%Case-control study on influence factors of birth defects

    Institute of Scientific and Technical Information of China (English)

    修新红; 袁丽; 王晓明; 陈玉华; 万爱华; 傅平

    2011-01-01

    Objective To investigate the influence factors of birth defects. Methods The congenital malformational fetuses born from 13 week of gestation to 7 days after birth were selected as the study group between April 1st, 2009 and March 31st, 2010. The health born fetuses were set as control in the same period. Case-control and the three-level of monitor network of birth defects were used in the study in the participating 75 hospitals (Qingdao Women and Children's Medical Center, Affiliated Hospital of Medical College Qingdao University, Qingdao Municipal Hospital, etc.) . The study and control group's parents were interviewed by an uniformed questionnaire which was designed specially with influence factors of birth defects. Results (1) There are 466 congenital malformational fetuses in the total of 77 231 fetuses collected in 75 hospitals. The congenital malformational rate accounts for about 6. 034‰. The top six defect diseases were congenital heart disease (112 cases) , total harelip (cleft lip; cleft lip with palate; 85 cases) ,polydactyly (53 cases) , neural tube defects (38 cases) , congenital hydrocephalus (37 cases) and limb reduction defect (27 cases) in turn, which amounts to 353 cases (54.48% , 353/648). (2) Their mother education level in the birth-defect group (25. 6%) were significantly lower than that in control group (30. 0% , P < 0. 05). (3) The rate of passive smoking, drinking, raising pets of the parents in birth-defect group were significantly higher than that in control group (P < 0. 05). (4) The rate of exposure to harmful chemical and physical factors of mothers in birth defects group (13.9% and 20. 5% , respectively) was higher than that in control group (1.1% and 11.7% , respectively) , the difference between which were significant (P < 0. 01) . The rate of disease (34. 3%) , fever (13. 1%) , taking drugs (33. 8%) in pregnancy period in birth defect group were higher than that in control group (13. 5% , 1.5% and 9. 9% ,respectively) , the

  16. Amelia: A Multi-Center Descriptive Epidemiologic Study in a Large Dataset from the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature

    Science.gov (United States)

    BERMEJO-SÁNCHEZ, EVA; CUEVAS, LOURDES; AMAR, EMMANUELLE; BAKKER, MARIAN K.; BIANCA, SEBASTIANO; BIANCHI, FABRIZIO; CANFIELD, MARK A.; CASTILLA, EDUARDO E.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, R. BRIAN; MASTROIACOVO, PIERPAOLO; MUTCHINICK, OSVALDO M.; RISSMANN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SIFFEL, CSABA; SZABOVA, ELENA; MARTÍNEZ-FRÍAS, MARÍA-LUISA

    2015-01-01

    This study describes the epidemiology of congenital amelia (absence of limb/s), using the largest series of cases known to date. Data were gathered by 20 surveillance programs on congenital anomalies, all International Clearinghouse for Birth Defects Surveillance and Research members, from all continents but Africa, from 1968 to 2006, depending on the program. Reported clinical information on cases was thoroughly reviewed to identify those strictly meeting the definition of amelia. Those with amniotic bands or limb-body wall complex were excluded. The primary epidemiological analyses focused on isolated cases and those with multiple congenital anomalies (MCA). A total of 326 amelia cases were ascertained among 23,110,591 live births, stillbirths and (for some programs) elective terminations of pregnancy for fetal anomalies. The overall total prevalence was 1.41 per 100,000 (95% confidence interval: 1.26–1.57). Only China Beijing and Mexico RYVEMCE had total prevalences, which were significantly higher than this overall total prevalence. Some under-registration could influence the total prevalence in some programs. Liveborn cases represented 54.6% of total. Among monomelic cases (representing 65.2% of nonsyndromic amelia cases), both sides were equally involved, and the upper limbs (53.9%) were slightly more frequently affected. One of the most interesting findings was a higher prevalence of amelia among offspring of mothers younger than 20 years. Sixty-nine percent of the cases had MCA or syndromes. The most frequent defects associated with amelia were other types of musculoskeletal defects, intestinal, some renal and genital defects, oral clefts, defects of cardiac septa, and anencephaly. PMID:22002956

  17. Prevention of birth defects in the pre-conception period: knowledge and practice of health care professionals (nurses and doctors in a city of Southern Brazil

    Directory of Open Access Journals (Sweden)

    Flávia Romariz Ferreira

    2015-10-01

    Full Text Available Background: Some congenital defects can be prevented in the pregestational stage. However, many health professionals are not prepared to provide counselling to couples regarding the same. Objective: This study aimed to assess the performance of doctors and nurses from a primary health-care unit in Florianopolis, Brazil, in preventing birth defects in the preconception period based on the recommendations of the Control Center of Disease Prevention. Materials and Methods: This descriptive cross sectional study was performed at a tertiary referral center. In this study, a semi-structured questionnaire was provided to 160 health professionals comprising doctors and nurses who were actively involved in providing primary health care in family health programs. The non-parametric Chi-square (χ2 test was used to analyse the data obtained through multiple choice questions. Results: Our results showed that although 81.9% of health professionals provided health-care assistance based on protocols, and only 46.2% professionals were aware of the presence of the topic in the protocol. Of the recommendations provided by the Control Center of Disease Prevention, the use of folic acid was the most prescribed. However, this prescription was not statistically different between nurses and doctors (P=0.85. Conclusion: This study identified the fragile nature in these professional’s knowledge about the prevention of birth defects in pre-conception period, as evidenced by the inconsistency in their responses.

  18. Converged Registries Solution (CRS)

    Data.gov (United States)

    Department of Veterans Affairs — The Converged Registries platform is a hardware and software architecture designed to host individual patient registries and eliminate duplicative development effort...

  19. Analysis of birth defects in Urumqi during 2011 to 2015%乌鲁木齐市2011年-2015年出生缺陷情况分析

    Institute of Scientific and Technical Information of China (English)

    李芳; 丁娟

    2016-01-01

    目的 研究乌鲁木齐市2011年~ 2015年出生缺陷的资料,探讨乌鲁木齐市主要出生缺陷类型、影响因素及变化规律,并提出干预措施.方法 对乌鲁木齐市2011年~ 2015年的出生缺陷资料进行分析,观察乌鲁木齐市出生缺陷的变化趋势.结果 2011-2015年5年间,乌鲁木齐市发生出生缺陷儿1422例,出生缺陷总发生率66.67/万,出生缺陷前5位依次为总唇裂、多指(趾)、神经管畸形、先天性脑积水、先天性心脏病.不同年份的出生缺陷顺位有所不同.结论 部分对于干预措施敏感的致死和严重致残出生缺陷发生率逐步下降,我市出生缺陷现有综合防治策略取得了明显的成效;出生缺陷防控工作重点的变化.为降低国产儿出生缺陷发生率,做好婚前医学检查、加强孕产妇孕前、孕期保健,增强出生缺陷防范意识,产检进行产前筛查和孕中期彩超排畸筛查,是降低围产儿出生缺陷发生率的有效措施.%Objective:Study data of birth defects,in Urumqi from 2013 ~ 2015,Discussion major types of birth defects in Urumqi,affecting factors and changes in laws and proposed interventions.Methods:Analysis of birth defects in Urumqi during 2011 to 2015,observing the change trend of birth defects in Urumqi.Results:2011-2015,five years,1422 cases of birth defects in Urumqi,the incidence of birth defects in total 66.67 / m,the top five birth defects of cleft lip,multi-finger (toe),and neural tube defects,congenital hydrocephalus and congenital heart disease.Different years of birth defects in the sequence is different.Conclusion:Part to the intervention sensitive to death or severe disability gradually decreased incidence of birth defects,birth defects existing obvious achievements have been made in the integrated control strategy;The change of birth defect prevention and control work key.In order to reduce the incidence of perinatal birth defects,completes the pre-marital medical

  20. 出生缺陷监测现状、疾病谱变化趋势与监测方法探讨%Birth defect monitoring status, disease spectrum change trend and methods of monitoring

    Institute of Scientific and Technical Information of China (English)

    张杏敏; 吴红宇; 胡南

    2011-01-01

    目的 以扬州市2005年-2010年的出生缺陷监测结果为基础,阐述我国出生缺陷监测现状,为进一步探讨我国出生缺陷监测方法、干预措施等提供有效的的数据支持,从而提高出生缺陷监测研究水平.方法 总结扬州市2005年-2010年出生缺陷诊断分类及其变化趋势,探讨出生缺陷监测方法和统计口径.结果 先天性心脏病、小于28w治疗性引产数、出生缺陷诊断无法归类而列为“其它”三者呈上升趋势.结论 只有全面了解出生缺陷监测现状,准确统计出生缺陷发生率及其分类,才能有针对性地制订干预措施,更加有效地预防和减少出生缺陷.%Objective: Taking Yangzhou 2005 - 2010 years of birth defects monitoring results as the basis, elaborated our country of birth defects monitoring status and provided effective data support for the further study of Chinese birth defects monitoring methods, as well as improving birth defects surveillance study level. Methods: To sum up 2005 - 2010 years of birth defects diagnosis classification and changing trend of birth defects of Yangzhou city. Explore monitoring method and -statistical standards. Results: Congenital heart diseases, the number of less than 28 weeks abortion treatment, birth defects diagnosis as "others" which could not be explicitly classified show ascendant trend. Conclusion; Only a comprehensive understanding of birth defects monitoring status, the accurate statistics of the incidence of birth defects and its classification, can be targeted to develop interventions that more effectively prevent and reduce the incidence of birth defects.

  1. Craniofacial birth defects: The role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention.

    Science.gov (United States)

    Trainor, Paul A

    2010-12-01

    Of all the babies born with birth defects, approximately one-third display anomalies of the head and face [Gorlin et al., 1990] including cleft lip, cleft palate, small or absent facial and skull bones and improperly formed nose, eyes, ears, and teeth. Craniofacial disorders are a primary cause of infant mortality and have serious lifetime functional, esthetic, and social consequences that are devastating to both children and parents alike. Comprehensive surgery, dental care, psychological counseling, and rehabilitation can help ameliorate-specific problems but at great cost over many years which dramatically affects national health care budgets. For example, the Center for Disease Control and Prevention estimates that the lifetime cost of treating the children born each year with cleft lip and/or cleft palate alone to be US$697 million. Treating craniofacial malformations, of which in excess of 700 distinct syndromes have been described, through comprehensive, well-coordinated and integrated strategies can provide satisfactory management of individual conditions, however, the results are often variable and rarely fully corrective. Therefore, better techniques for tissue repair and regeneration need to be developed and therapeutic avenues of prevention need to be explored in order to eliminate the devastating consequences of head and facial birth defects. To do this requires a thorough understanding of the normal events that control craniofacial development during embryogenesis. This review therefore focuses on recent advances in our understanding of the basic etiology and pathogenesis of a rare craniofacial disorder known as Treacher Collins syndrome and emerging prospects for prevention that may have broad application to congenital craniofacial birth defects.

  2. Knowledge and use of folic acid for birth defect prevention among women of childbearing age in Shanghai, China: A prospective cross-sectional study

    OpenAIRE

    Liang, Huan; MA, DUAN; Zhou, Shu-Feng; Li, Xiaotian

    2011-01-01

    Summary Background This study aimed to assess the knowledge, attitude, and practice of folic acid intake for prevention of birth defects in Chinese women of child-bearing age. Material/Methods In this prospective cross-sectional study, a total of 1,338 women aged 20–45 years were randomly selected for interview. Data on folic acid knowledge and information on folic acid intake in the subjects were collected. Age, education, contraception, and status of family planning were used as the indepen...

  3. Analysis of the Monitoring Results of Birth Defect in Hospitals Between 2001 and 2010 in Changsha%长沙市2001~2010年医院出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    祖月娥; 朱琳; 周红女; 周燕飞; 李杏秀; 王卫东; 徐扬; 林蓓蓓

    2013-01-01

    [Objective]To analyze the monitoring results of birth defect in hospital between 2001 and 2010 in Changsha in order to provide the basis for formulating the policy to reduce the birth defect rate of hospitals by health administrative department .[Methods] The statistical data from 13 birth defect monitoring hospitals of Changsha were analyzed .All the 13 hospital were accorded with birth defect definition and diagnostic standard in Chinese birth defect monitoring program and Chinese birth defect monitoring manual .All birth defect children were examined and registered by the trained physicians .The classification and statistical analysis were taken .[Results] In the past 10 years ,there were 173527 perinatal children born in 13 birth defect surveillance hospitals . Among them ,3856 children were birth defects .The total incidence rate was 222 .16/10000 .The incidence rate of birth defect during 10 years was increased obviously .The top 5 birth defects were congenital heart disease ,outer ear and other malformations ,cleft lip complicated with cleft palate ,multi-finger(toe) and congenital hydroceph-alus .Except the constituent ratio of congenital heart disease was increased ,the constituent ratio of 4 other birth defects had the declining trend .[Conclusion] The strategical change of the prevention mode of birth defect should be implemented so as to reduce the birth defect .%[目的]通过分析长沙市2001~2010年医院出生缺陷监测结果数据,为上级医疗行政部门制定降低医院出生缺陷率的政策提供依据。[方法]参照长沙市13所出生缺陷监测医院的统计数据。13所医院均按照《中国出生缺陷监测方案》及《中国出生缺陷监测手册》中有关出生缺陷的定义特征和诊断标准,经专职医生临床体检和相关检查确诊并分类统计。[结果]10年中13所出生缺陷监测医院总出生围生儿为173527例,出生缺陷3856例,总发生率为222.16/万,10年间出生缺

  4. Epidemiologic study of neural tube defects in Los Angeles County. I. Prevalence at birth based on multiple sources of case ascertainment

    Energy Technology Data Exchange (ETDEWEB)

    Sever, L.E. (Pacific Northwest Lab., Richland, WA); Sanders, M.; Monsen, R.

    1982-01-01

    Epidemiologic studies of the neural tube defects (NTDs), anencephalus and spina bifida, have for the most part been based on single sources of case ascertainment in past studies. The present investigation attempts total ascertainment of NTD cases in the newborn population of Los Angeles County residents for the period 1966 to 1972. Design of the study, sources of data, and estimates of prevalence rates based on single and multiple sources of case ascertainment are here discussed. Anencephalus cases totaled 448, spina bifida 442, and encephalocele 72, giving prevalence rates of 0.52, 0.51, and 0.08 per 1000 total births, respectively, for these neural tube defects - rates considered to be low. The Los Angeles County prevalence rates are compared with those of other recent North American studies and support is provided for earlier suggestions of low rates on the West Coast.

  5. Avaliação das declarações de nascido vivo como fonte de informação sobre defeitos congênitos Evaluation of the birth certificates as source of information on birth defects

    Directory of Open Access Journals (Sweden)

    Ana Lívia Geremias

    2009-03-01

    Full Text Available OBJETIVO: Estimar a prevalência de defeitos congênitos (DC em uma coorte de nascidos vivos (NV vinculando-se os bancos de dados do Sistema de Informação de Mortalidade (SIM e do Sistema de Informação sobre Nascidos Vivos (SINASC. MÉTODOS: Estudo descritivo para avaliar as declarações de nascido vivo como fonte de informação sobre DC. A população de estudo é uma coorte de NV hospitalares do 1º semestre de 2006 de mães residentes e ocorridos no Município de São Paulo no período de 01/01/2006 a 30/06/2006, obtida por meio da vinculação dos bancos de dados das declarações de nascido vivo e óbitos neonatais provenientes da coorte. RESULTADOS: Os DC mais prevalentes segundo o SINASC foram: malformações congênitas (MC e deformidades do aparelho osteomuscular (44,7%, MC do sistema nervoso (10,0% e anomalias cromossômicas (8,6%. Após a vinculação, houve uma recuperação de 80,0% de indivíduos portadores de DC do aparelho circulatório, 73,3% de DC do aparelho respiratório e 62,5% de DC do aparelho digestivo. O SINASC fez 55,2% das notificações de DC e o SIM notificou 44,8%, mostrando-se importante para a recuperação de informações de DC. Segundo o SINASC, a taxa de prevalência de DC na coorte foi de 75,4%00 NV; com os dados vinculados com o SIM, essa taxa passou para 86,2%00 NV. CONCLUSÕES: A complementação de dados obtida pela vinculação SIM/SINASC fornece um perfil mais real da prevalência de DC do que aquele registrado pelo SINASC, que identifica os DC mais visíveis, enquanto o SIM identifica os mais letais, mostrando a importância do uso conjunto das duas fontes de dados.OBJECTIVE: To obtain the prevalence of birth defects in a live birth cohort, linking the live birth information system (SINASC and the mortality information system (SIM databases. METHODS: Descriptive study to assess linked databases of hospital live births (LB and neonatal deaths of resident mothers that occurred in the city of S

  6. The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects

    Directory of Open Access Journals (Sweden)

    Fabio eCoppedè

    2015-06-01

    Full Text Available Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions of chromosome 21, favoring its abnormal segregation during maternal meiosis. Subsequently, more than 50 small case-control studies investigated whether or not maternal polymorphisms of folate pathway genes could be risk factors for the birth of a child with Down syndrome (DS, yielding conflicting and inconclusive results. However, recent meta-analyses of those studies suggest that at least three of those polymorphisms, namely MTHFR 677C>T, MTRR 66A>G, and RFC1 80G>A, are likely to act as maternal risk factors for the birth of a child with trisomy 21, revealing also complex gene-nutrient interactions. A large-cohort study also revealed that lack of maternal folic acid supplementation at peri-conception resulted in increased risk for a DS birth due to errors occurred at maternal meiosis II in the aging oocyte, and it was shown that the methylation status of chromosome 21 peri-centromeric regions could favor recombination errors during meiosis leading to its malsegregation. In this regard, two recent case-control studies revealed association of maternal polymorphisms or haplotypes of the DNMT3B gene, coding for an enzyme required for the regulation of DNA methylation at centromeric and peri-centromeric regions of human chromosomes, with risk of having a birth with DS. Furthermore, congenital heart defects (CHD are found in almost a half of DS births, and increasing evidence points to a possible contribution of lack of folic acid supplementation at peri-conception, maternal polymorphisms of folate pathway genes, and resulting epigenetic modifications of several genes, at the basis of their occurrence. This review summarizes available case-control studies and literature meta-analyses in order to provide a critical and up to date overview of what we currently know in this

  7. 广西高发出生缺陷发生的影响因素分析%Influencing factors of high-incidence birth defects in Guangxi

    Institute of Scientific and Technical Information of China (English)

    刘湘红; 曾萼; 丘小霞; 刘伟; 陈玉柱

    2015-01-01

    目的 探讨广西高发出生缺陷发生的影响因素,为制定出生缺陷的干预措施提供依据. 方法 采用成组病例对照的研究方法,对广西7个市3 175例出生缺陷围产儿(包括先天性心脏病、唇腭裂、先天性脑积水、神经管缺陷、尿道下裂等)和3 179例正常围产儿的父母进行问卷调查,并对可能影响高发出生缺陷发生的相关因素进行单因素及多因素logistic回归分析. 结果 多因素logistic回归分析结果显示:父亲年龄及吸烟程度、叶酸指数与高发出生缺陷相关(P<0.05). 高发出生缺陷发生的危险因素包括孕早期未接受过优生检测、母亲孕早期患病、母亲怀孕前患病、母亲孕早期用药、母亲怀孕前后接触过猫狗等宠物、母亲有特殊食品嗜好(P均<0.05). 结论 母亲孕早期未接受优生检测、孕前/早期患病、孕早期用药、怀孕前后有宠物接触史以及母亲有特殊食品嗜好是广西地区高发出生缺陷发生的危险因素,在广西可从孕前与孕期保健、生活环境因素等多方面进行出生缺陷干预.%Objective To explore the influencing factors of high-incidence birth defects in Guangxi so as to provide the basis for formulating the intervention measures of birth defects.Methods A group case-control study was conducted, in which a questionnaire survey was carried out among parents of 3 175 perinatal infant with birth defects(including congenital heart disease,cleft lip and cleft palate,congenital hydrocephalus,neural tube defects and hypospadias) and 3 179 normal perinatal infants from 7 cities in Guangxi. Univariate and multivariate logistic regression analysis were used to analyze the related influencing factors of high-incidence birth defects. Results Multivariate logistic regression analysis revealed that age,severity of smoking and folacin index of fathers correlated with high-incidence birth defects(P<0.05).The risk factors for the occurrence of high

  8. 宁波市北仑区2007~2010年出生缺陷调查分析%Investigation and analysis of birth defection from 2007 to 2010 in Beilun district Ningbo city

    Institute of Scientific and Technical Information of China (English)

    胡波; 王健民; 吴庆国; 王娇珍; 乐福文; 吴怀

    2012-01-01

    Objective To provide basic statistics for prevention and intervention of birth defection in this area, through understanding basic condition of the happening of children birth defection and constitution of diseases. Methods Information on birth defection registration during 4 years in whole district was reviewed, and birth defection diseases were classified and relevant data were calculated and analyzed. Results A total of 9665 perinatals in the district were monitored, including 509 birth defection children; the rate of birth defection was 5. 27% from 2007 to 2010. Birth defection in the top three diseases were: congenital heart diseases, limb deformities, eye and ear deformities. Conclusion The situation of birth defection in Beilun district isnt optimistic, and the popularization of eugenic knowledge, surveillance and intervention of birth defection must be strengthened, which is one of the most important measures to take to improve population quality.%目的 分析宁波市北仑区儿童出生缺陷的发生及其病种构成的基本情况,为本地区出生缺陷预防干预提供基本数据.方法 回顾研究该区14家医院4年所有出生缺陷登记的资料,对出生缺陷病种进行归类,将相关数据进行统计整理.结果 2007年至2010年的4年间,该区共监测9 665例围生儿,其中有出生缺陷509例,出生缺陷率5.27%.出生缺陷居前三位的病种依次为:先天性心脏病,四肢畸形和眼耳畸形.结论 北仑区人口出生缺陷情况不容乐观,必须加强优生优育知识的普及,加强对出生缺陷的监测和干预,这是提高人口素质的重要环节之一.

  9. Conjoined Twins : A Worldwide Collaborative Epidemiological Study of the International Clearinghouse for Birth Defects Surveillance and Research

    NARCIS (Netherlands)

    Mutchinick, Osvaldo M.; Luna-Munoz, Leonora; Amar, Emmanuelle; Bakker, Marian K.; Clementi, Maurizio; Cocchi, Guido; Dutra, Maria da Graca; Feldkamp, Marcia L.; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, Brian; Marengo, Lisa K.; Martinez-Frias, Maria-Luisa; Mastroiacovo, Pierpaolo; Metneki, Julia; Morgan, Margery; Pierini, Anna; Rissman, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Siffel, Csaba; Szabova, Elena; Arteaga-Vazquez, Jazmin

    2011-01-01

    Conjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. The process by which monozygotic twins do not fully separate but form CT is not well understood. The purpose of the present study was

  10. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight

    DEFF Research Database (Denmark)

    Jensen, Christine B; Storgaard, Heidi; Dela, Flemming;

    2002-01-01

    Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two...

  11. Ethical aspects of soft tissue engineering for congenital birth defects in children--what do experts in the field say?

    NARCIS (Netherlands)

    Oerlemans, A.J.M.; Rodrigues, C.H.; Verkerk, M.A.; Berg, P.P. van den; Dekkers, W.J.M.

    2010-01-01

    This article is part of the EuroSTEC project, which aims at developing tissue engineering-based treatments for structural disorders present at birth. EuroSTEC is positioned at the intersection of three areas with their own ethical issues: (1) regenerative medicine, (2) research with pregnant women a

  12. Ethical aspects of soft tissue engineering for congenital birth defects in children : what do experts in the field say?

    NARCIS (Netherlands)

    Oerlemans, A.J.; Rodrigues, Catarina; Verkerk, M.A.; van den Berg, P.P.; Dekkers, W.J.M.

    2010-01-01

    This article is part of the EuroSTEC project, which aims at developing tissue engineering-based treatments for structural disorders present at birth. EuroSTEC is positioned at the intersection of three areas with their own ethical issues: (1) regenerative medicine, (2) research with pregnant women a

  13. Analysis of risk factors of birth defects in Shaanxi Province%陕西省出生缺陷的相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    杨杨; 曾令霞; 颜虹

    2011-01-01

    Objective To explore the factors influencing birth defects in Shaanxi Province and then provide scientific evidence for intervention strategies. Methods Stratified random cluster sampling method was adopted.Totally 124 towns were sampled from 12 counties of 9 cities in Shaanxi Province. Household survey was carried out among 13 273 women who were residents and had conceived from October 2007 to July 2009, and all of these women had 28 weeks' gestational age. We collected 7 531 complete questionnaires finished for the progestational and pregnant period. Unconditional logistic regression was performed to analyze the risk factors by using SPSS13.0software. Results The results of logistic regression showed that the risk factors for birth defects were by turns the birth defects history of patrilineal family (OR = 14. 283), poor mental state (OR = 10. 835), abnormal pregnancy and reproductive history (OR = 8. 264), mothers living in rural areas ( OR = 5. 067), the history of alcohol intake in pregnancy (OR = 4. 598), mother's age higher than 35 years (OR = 3. 696), exposure to agricultural chemicals during pregnancy (OR=3. 507), drinking strong tea during pregnancy (OR = 1. 993), taking folic acid during pregnancy (OR=0. 549) and higher family income per capita (OR = 0. 422), which were the protective factors of birth defects. Conclusion We should strengthen publicity in scientific knowledge of pre-natal and post-natal care,increase self-care consciousness of women of childbearing age, improve their living environment and change the unhealthy lifestyle. These strategies play a very important role in reducing the prevalence rate of birth defects in Shaanxi Province.%目的 探讨陕西省出生缺陷发生的影响因素,为采取有针对性的干预措施提供依据.方法 应用分层随机整群抽样方法,抽取陕西省9市12个区县共124个乡镇.对终止妊娠日期发生在2007年10月至2009年7月间且孕满28周的13273名妇女进行入户调查.要求

  14. 2007~2008年鄂州市围产儿出生缺陷情况调查%Investigation on perinatal birth defects in ezhou city from 2007 to 2008

    Institute of Scientific and Technical Information of China (English)

    艾方红; 詹险峰

    2011-01-01

    目的 了解本地区围产儿出生缺陷的发生率、种类及构成,探讨出生缺陷影响因素和产前诊断的不足.方法 收集本院2007~2008分娩的产妇及围产儿资料,对之进行分析.结果 鄂州市2007~2008年围产儿出生缺陷发生率为8.26‰,出生缺陷类型主要有唇腭裂、多指、尿道下裂等.结论 加强孕前期一围孕期保健预防工作及围产期出生缺陷监测诊断工作,减少出生缺陷儿的发生.%Objective: To study the incidence and type of perinatal birth defect in Ezhou city and explore the related risk factors and the deficiency of prenatal diagnosis.Methods: Data of perinatal birth defects were from Ezhou central hospital from 2007 to 2008.Results: The incidence of birth defect in Ezhou city was 8.26‰.The common perinatal birth defects were listed as follows: cleft lip,fingers, and hypospadias, etc.Conclusion: Pregnancy prevention and prenatal diagnosis should be improved to reduce the incidence of birth defect.

  15. Use of folic acid and delivery outcome: a prospective registry study.

    Science.gov (United States)

    Källén, Bengt A J; Olausson, Petra Otterblad

    2002-01-01

    Periconceptional use of folic acid is thought to reduce the risk for both neural tube defects and other congenital malformations. Most published data were obtained retrospectively. We used the Swedish Medical Birth Registry to study congenital malformations in infants born of women who reported the use of folic acid in early pregnancy (of which 70% probably used it also preconceptionally) and compared them with population rates. We divided the material according to two major confounders: subfertility problems and use of antiepileptic drugs. We found no protective effect of folic acid tablet use on the rate of congenital malformations but data on neural tube defects were scarce. Our results support the scepticism recently expressed in the literature on the beneficial effect of folic acid in preventing congenital malformations, especially of a non-neural tube defect type.

  16. Analysis of monitoring results of birth defects in Jingning county in 2009 and 2010%景宁县2009-2010年出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    王佩英

    2012-01-01

    Objective To analyze incidence of birth defects in Jingning county and relevant influential factors for the development and evaluation of preventive measures. Methods Birth defects monitoring data were obtained from 4 hospitals in 2009 and 2010 in Jingning county following guidelines of Birth defects monitoring program of Jingning county. The data were analyzed including the incidence of birth defects, defect type, occurrence of birth defects of mothers during pregnancy and all the cases were followed up. Results In two years, the total incidence rate of birth defects was 1.064%, in a total of 26 cases of birth defects, 23 were single defect and 3 were multiple defects. Defect types included five multiple fingers, congenital heart disease, cleft lip, cleft palate, encephalocele. Conclusions Birth defects show a trend of increase in this county. This is most likely due to improvement of technology in perinatal prenatal diagnosis and early postnatal diagnosis. Influential factors that may cause birth defects include maternal illness, unsafe medications during pregnancy and maternal genetic factor. These results indicate that it is necessary to enhance pre-pregnancy care, improve the quality of premarital medical examination, pay attention to genetic consulting and prenatal health care, especially in early pregnancy care. It is also necessary to carry out prenatal screening and improve knowledge on birth defects prevention so as to reduce the occurrence of birth defects.%目的 分析浙江省景宁县出生缺陷的发生状况和影响因素,为制定和评价预防措施提供依据.方法 对景宁县内4家医院依据《景宁县出生缺陷监测方案》要求上报的2009年和2010年出生缺陷监测数据进行汇总,分析出生缺陷的发生率、缺陷类型、发生出生缺陷儿母亲孕期情况,并跟踪随访.结果 共监测景宁县两年中2 443例围产儿,出生缺陷26例,总出生缺陷发生率为10.64‰,其中单发缺陷23

  17. Investigation and analysis of 0 ~14 years old children with birth defects in Three Gorges Reservoir Area%三峡库区0~14岁儿童出生缺陷调查与分析

    Institute of Scientific and Technical Information of China (English)

    马明福; 李川海; 杨皓; 付新云; 李家菊; 崔蓉; 张丹妍; 李安奇; 李练兵

    2013-01-01

    Objective:To understand Three Gorges Reservoir Area 7 counties 0 ~ 14 years old children's birth defects present situation,type,incidence,urban and rural children's birth defect occurrence,occurring at different positions of the situation,collect birth defects/genetic disease information data to prevent birth defects and provide the scientific basis.Methods:According to ICD-10 coding diseases listed design questionnaire,stratified cluster random sampling was used to the scene to carry out investigations on the 0 ~ 14 years old children suffering from birth defects.Results:There were 7 977 meals available questionnaire,including 24 types of birth defect with 158 people,and the incidence of birth defects was 19.81‰.The first 4 types of the study were cleft lip (73 cases,incidence 9.152‰) ; limb deformities (17 cases,incidence 2.137 ‰) ; hydrocephalus (14 cases,incidence 1.755‰) ; cardiac malformations (12 cases including 5 cases of boys and 7 cases of girls,incidence 1.504‰).There were 95 boys with the incidence of birth defects 22.37‰,63 girls with the incidence of birth defects 16.89 ‰.The boy's incidence of birth defects was obviously higher than that of girl (chi-square =204.44,P <0.005).There were 42 children with birth defects in 2 198 urban children (27.55%) and 116 children with birth defects in 5 779 rural children (72.45%).The urban children's birth defect rate was 19.11‰ and the countryside was 20.07‰.There was no statistical difference (chi-square =0.076,P =0.782) between them.Location was the first facial defects 86 cases (54.43%),the second for nerve defect 20 cases (12.66%),the third for limbs defect 17 cases (10.76%),the fourth for heart defects 12 cases (7.59%),the fifth for urogenital defect 6 patients (3.80%),other defects 17 cases (10.76%).There was significant difference (chi-square =34.11,P <0.01) between the first birth defects and other parts.Conclusion:Birth defects' monitoring area,monitoring time

  18. Epidemiologic study of neural tube defects in Los Angeles County. II. Etiologic factors in an area with low prevalence at birth

    Energy Technology Data Exchange (ETDEWEB)

    Sever, L.E.

    1982-01-01

    Epidemiologic characteristics of neural tube defect (NTD) births occurring in Los Angeles County, California, residents during the period 1966-1972 are presented. The prevalence at birth was 0.52/1000 births for anencephalus, 0.51/1000 for spina bifida, and 0.08/1000 for encephalocele, rates considered to be low for a predominantly white population. We hypothesized that environmental (nongenetic) factors are of less etiologic importance in a low-prevalence population than in areas or time periods with high prevalence. We tested that hypothesis by examining epidemiologic characteristics of NTDs in Los Angeles County and comparing them with high-prevalence populations. The data did not support a major etiologic role for environmental factors: (1) no significant differences between rates by month of birth or conception; (2) no significant association with maternal age or parity for anencephalus; for spina bifida a significant maternal age effect (P < 0.01) and for encephalocele a parity effect (P < 0.02); and (3) no significant relationship with father's occupational class for either anencephalus or encephalocele but a marginally significant (P < 0.05) inverse association for spina bifida when a statistic based on ordinal relationships was used. Findings supporting the importance of genetic factors in etiology included: (1) a high percentage of males; (2) a higher twin concordance rate than in high-prevalence populations; and (3) an anencephalus rate among blacks comparable with rates for blacks in other United States populations. Our findings in conjunction with those from other areas and times of low prevalence suggest environmental factors play a relatively insignificant role in the etiology of NTDs in such populations.

  19. 黄山市2006~2010年出生缺陷调查结果分析%The analysis of birth defects prevalence of Huangshan from 2006 to 2010

    Institute of Scientific and Technical Information of China (English)

    章世妹; 盛玮; 吉次秋; 胡红喜; 曾令芳; 冯建华; 汪丽霞

    2012-01-01

    Objective To investigate the epidemiological features of birth defects in Huangshan in order to determine the high - risk population and areas. Methods The birth defect condition was household surveyed among perinatal infants, including dead fetus stillbirths and therapeutic abortion ), and children aged 0 to 5 with their mothers underwent in - depth personal interviews and cluster sampling retrospective study on January f, 2006 to December 3f , 20f0 in 7 prefectures( counties ) covering f Of towns and 6 streets. The confirmation of the birth defects was based on clinical diagnosis. The categories were defined with National Birth Defect Monitoring Program. Results There were 981 birth defects diagnosed in 5 years. The incidence rate of birth defects was 158. 69 per 10000 infants. The incidence in male infants was 82. 82 per 10000 infants and 63. 57 per 10000 infants in female infants. The top birth defects were congenital heart disease, total cleft lip and palate, polydactyly, congenred hydrocephaly, urogenital abnormality and neural tube defects. Conclusion The current situation of birth defects among children aged 0 to 5 in Huangshan has been evaluated, which shows an upward trend year by year. The incidence is higher in country than that in city and higher in male infants than females, but the difference between them has no statistical significance. So the key point of the birth defect prevention should be put in country areas. The hygienic knowledge of pregnant woman should be enhanced, especially in the top 6 birth defects mentioned above. Additionally, we should explore the reason of the high incidence of birth defects in order to provide basis for further birth defect prevention.%目的 了解黄山市0~5岁儿童出生缺陷的发生率、种类及顺位,确定重点预防人群和区域.方法 采用个人访谈、整群回顾性调查的方法对黄山市三区四县101个乡镇和6个街道在2006年1月1日至2010年12月31日期间出生的围生

  20. Neural Tube Defects

    Science.gov (United States)

    Neural tube defects are birth defects of the brain, spine, or spinal cord. They happen in the ... that she is pregnant. The two most common neural tube defects are spina bifida and anencephaly. In ...

  1. Analysis of peripregnancy health care effects on birth defects%围孕期保健对出生缺陷的影响分析

    Institute of Scientific and Technical Information of China (English)

    刘葵; 吕海荣

    2014-01-01

    目的:分析围孕期保健对围产儿出生缺陷的影响。方法:选取西安市第四医院2013年10月1日~2013年12月25日收治1716例产妇为研究对象,对其临床资料进行回顾分析。结果:围孕期叶酸的补充可以显著降低神经管畸形的发生风险,差异有统计学意义(P<0.05);围孕期营养状况及孕妇的家庭收入等因素为减少出生缺陷发生的保护性因素,差异有统计学意义(P<0.05);出生缺陷的危险因素分别为孕妇接触职业危险因素、孕期患慢性病、孕期感冒、孕早期出血流产症状、孕期接触宠物、孕前或孕期房屋新装修、被动吸烟、孕期服药及孕期精神紧张或过度焦虑,差异有统计学意义(P<0.05)。结论:通过加强围孕期保健,减少和控制孕期危险因素,可以预防和减少出生缺陷,提高人口出生质量。%Objective:To analyze the confining effect of health care during pregnancy on perinatal birth defects.Methods:Xi'an City Fourth Hospital from October 1, 2013 to December 25, 2013 a total of 1716 cases of pregnant women as the research object, this was a retrospective a-nalysis of the clinical data.Results:Periconceptional folic acid supplementation could significantly reduce the risk of neural tube malformation, the difference was statistically significant (P<0.05);perioperative nutritional status and maternal family income and other factors as the protec-tive factor for reducing the incidence of birth defects, there was statistically significant difference (P <0.05);risk factors of birth defects were pregnant women contact occupation risk factors during pregnancy, chronic disease, pregnancy, abortion of early pregnancy bleeding symptoms of colds, pet contacting during pregnancy, before or during pregnancy, passive smoking, the new housing decoration medication during pregnancy and maternal stress or excessive anxiety, the difference was statistically

  2. Relationship between knowledge of birth defects and culture, economy%出生缺陷知识与文化和经济的关系

    Institute of Scientific and Technical Information of China (English)

    陈文英; 张玲; 张绍强

    2012-01-01

    目的:了解孕妇对预防出生缺陷的知识、态度、行为情况,为进一步完善婚前保健、孕前保健及围产期保健服务提出合理化建议,提高出生人口素质.方法:采用分层抽样和随机抽样的方法,抽取深圳市龙岗区三个街道的90例孕期妇女作为调查对象,利用自行设计的调查表,进行面对面问卷调查,了解孕期妇女出生缺陷的知信行(KAP)情况.结果:文化层次高的孕妇,夫妇双方婚前医学检查率明显高于文化水平低者,差异有统计学意义(x2=6.771 7,P<0.05);文化程度越高的孕妇对孕期保健、预防出生缺陷知识掌握得越多.对孕期“保持良好心情”的知晓率以月收入4000~7000元组最高(95.00%),月收入7 000元以上组的知晓率最低(61.54%);在孕期“注意少接触农药/油漆”及“注意少接触猫狗等”行为方面也有不同,家庭人均月收入越高的孕妇对上述行为的重视程度越高.结论:文化程度与家庭经济状况是孕期妇女掌握出生缺陷相关知识的影响因素.%Objective; To understand the knowledge, attitude and practice (KAP) of pregnant women to prevention of birth defects , put forward reasonable suggestions for further perfecting premarital health care, prenatal health care, and perinatal heath care services, improve the quality of birth population. Methods: Stratified random sampling method was used to select 90 pregnant women from three streets of Longgang district as respondents, a self - designed questionnaire was adopted to survey the respondents face - to - face, KAP conditions of the pregnant women to birth defects were understood. Results: The rate of premarital examination in couples with the pregnant women having high educational level was statistically significantly higher than that in couples with the pregnant women having low educational level (x2 = 6. 771 7, P <0. 05) ; the higher the educational level of pregnant women was, the higher the

  3. Birth Outcomes Among Military Personnel Following Exposure to Documented Open-Air Burn Pits Before and During Pregnancy

    Science.gov (United States)

    2012-06-01

    CM codes in the range of 740.x to 760.x.18 Registry data are routinely validated by review of a sample of birth defect cases with criteria established...mitosis, meiosis , differentiation, and maturation, is believed to be highly susceptible to environmental insults.12 It seems likely that if burn pit...Howel D. Particulate air pollution and fetal health: a systematic review of the epidemiologic evidence. Epidemiology. 2004;15:36–45. 7. Sram RJ, Binkova B

  4. Analysis of the Influencing Factors on 170 Cases of Birth Defects in a Hospital, Guizhou%贵州省某医院170例新生儿出生缺陷的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    罗敏

    2012-01-01

    Objective: The paper aims of understanding the change of incidence of birth defects and its influencing factors, to provide the basis for birth defects prevention and intervention. Methods: Collected 170 cases of birth defects from the birth defects monitoring data in2003 - 2011 ,the chi-square test were used for analysis of the change of incidence of birth defects and its influencing factors. Results: The incidence of thebirth defects was 142.6 per million, the prenatal diagnosis rate is 17.65%, abnormal factors accounted for 41.12%; The first five rows of the birth defects are the Outer ear other deformities, multi-fingered, neural tube defects, clubfoot varus and limb shortening; Child born defective has a high incidence with mother below 20. Conclusion: Strengthening preconception care, prenatal care, prenatal screening and early pregnancy and pregnancy folic acid specification can be taken to prevent and reduce the incidence of birth defects.%目的:探讨新生儿出生缺陷的影响因素,为新生儿出生缺陷的预防和干预提供依据.方法:基于贵州省某医院2003 -2011年出生缺陷的监测数据,运用卡方检验分析170例新生儿出生缺陷的特征变化及其影响因素.结果:该院出生缺陷检出率为142.6/万,产前诊断率为17.65%,异常因素占41.12%;出生缺陷前5位分别为外耳其它畸形、多指、神经管缺陷、马蹄足内翻和肢体短缩;母亲年龄<20岁缺陷儿发生率较高.结论:加强孕前保健、孕期保健、产前筛查和孕前与孕早期叶酸规范服用,是当前预防和减少出生缺陷发生的主要工作.

  5. 深圳市298031例围产儿出生缺陷监测流行病学特征%Epidemiological characteristic of birth defect of 298031 perinatal in Shenzhen

    Institute of Scientific and Technical Information of China (English)

    丁蓉; 颜春荣; 龚林

    2012-01-01

    Objective: To study the cause and risk factors of birth defect and to reduce birth defect through institute health care and disease prevents measures. Methods: The birth defect was measured in all perinatal, including live birth, stillbirth, induced abortion and neonatal death, in all Shenzhen hospital from 2008 to 2009 according to Shenzhen uniform surveillance scheme. Results: Among 289 031 births, the incidence of birth defect was 16. 52‰ (4 924/298 031), live deformity was 13. 84‰ (4 125/298 031) . The incidence of birth defect was 69.42‰ (3 418/4 924) in floating population . The incidence of birth defect was 20. 34‰ in lower knowledge level puerpera and 20.41%p in puerpera age > 35 group, which was much higher than other age groups, the difference was significant (P < 0.025) . The rate of birth defect in mature puerperal was 71.45% (3518/4924) . The incidence of birth defect in congenital heart disease and body check was 9.95‰ (2 967/298 031), which took 60.25% (2 967/4 924) in all kind of defect Defect birth liability took 83. 77% (4 125/4 924 ) . Conclusion: The rate of un - unitary body check is higher. The prenatal detection should be strengthen. It is key for prevent birth defect to popularization pregnant hearth care knowledge, develop hearth care service, elect right age to pregnancy.%目的:研究深圳市出生缺陷的发生状况及相关危险因素,为减少出生缺陷制定预防保健措施提供依据.方法:按深圳市统一的监测方案,对2008~ 2009年深圳市所有医院孕20周-产后7天分娩的围产儿(包括活产、死胎、死产、引产及产后7天内死亡)进行出生缺陷监测.结果:289 031例围产儿中出生缺陷发生率为16.52%(4 924/298 031),活产畸形率为13.84‰ (4 125/298 031),缺陷发生在流动人口中的比例为69.42%(3 418/4 924).产母文化程度低、年龄>35岁组发病率分别为20.34‰、20.41‰,高于其他年龄组,经检验P<0.025,差异有统计学意义.

  6. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects

    Directory of Open Access Journals (Sweden)

    Brian C. Gibbs

    2016-03-01

    Full Text Available Planar cell polarity (PCP is controlled by a conserved pathway that regulates directional cell behavior. Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj in Prickle1 (Pk1, a PCP component, exhibit developmental phenotypes involving cell polarity defects, including skeletal, cochlear and congenital cardiac anomalies. Bj mutants die neonatally with cardiac outflow tract (OFT malalignment. This is associated with OFT shortening due to loss of polarized cell orientation and failure of second heart field cell intercalation mediating OFT lengthening. OFT myocardialization was disrupted with cardiomyocytes failing to align with the direction of cell invasion into the outflow cushions. The expression of genes mediating Wnt signaling was altered. Also noted were shortened but widened bile ducts and disruption in canonical Wnt signaling. Using an in vitro wound closure assay, we showed Bj mutant fibroblasts cannot establish polarized cell morphology or engage in directional cell migration, and their actin cytoskeleton failed to align with the direction of wound closure. Unexpectedly, Pk1 mutants exhibited primary and motile cilia defects. Given Bj mutant phenotypes are reminiscent of ciliopathies, these findings suggest Pk1 may also regulate ciliogenesis. Together these findings show Pk1 plays an essential role in regulating cell polarity and directional cell migration during development.

  7. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.

    Science.gov (United States)

    Gibbs, Brian C; Damerla, Rama Rao; Vladar, Eszter K; Chatterjee, Bishwanath; Wan, Yong; Liu, Xiaoqin; Cui, Cheng; Gabriel, George C; Zahid, Maliha; Yagi, Hisato; Szabo-Rogers, Heather L; Suyama, Kaye L; Axelrod, Jeffrey D; Lo, Cecilia W

    2016-02-16

    Planar cell polarity (PCP) is controlled by a conserved pathway that regulates directional cell behavior. Here, we show that mutant mice harboring a newly described mutation termed Beetlejuice (Bj) in Prickle1 (Pk1), a PCP component, exhibit developmental phenotypes involving cell polarity defects, including skeletal, cochlear and congenital cardiac anomalies. Bj mutants die neonatally with cardiac outflow tract (OFT) malalignment. This is associated with OFT shortening due to loss of polarized cell orientation and failure of second heart field cell intercalation mediating OFT lengthening. OFT myocardialization was disrupted with cardiomyocytes failing to align with the direction of cell invasion into the outflow cushions. The expression of genes mediating Wnt signaling was altered. Also noted were shortened but widened bile ducts and disruption in canonical Wnt signaling. Using an in vitro wound closure assay, we showed Bj mutant fibroblasts cannot establish polarized cell morphology or engage in directional cell migration, and their actin cytoskeleton failed to align with the direction of wound closure. Unexpectedly, Pk1 mutants exhibited primary and motile cilia defects. Given Bj mutant phenotypes are reminiscent of ciliopathies, these findings suggest Pk1 may also regulate ciliogenesis. Together these findings show Pk1 plays an essential role in regulating cell polarity and directional cell migration during development.

  8. Genetic Testing Registry

    Science.gov (United States)

    ... Medicine Bookshelf Database of Genotypes and Phenotypes (dbGaP) Genetic Testing Registry Influenza Virus Map Viewer Online Mendelian Inheritance ... My NCBI Sign in to NCBI Sign Out Genetic Testing Registry All GTR Tests Conditions/Phenotypes Genes Labs ...

  9. EMI Registry Design

    CERN Document Server

    Memon, S

    2011-01-01

    Grid services are the fundamental building blocks of today's Distributed Computing Infrastructures (DCI). The discovery of services in the DCI is a primary function that is a precursor to other tasks such as workload and data management. In this context, a service registry can be used to fulfil such a requirement. Existing service registries, such as the ARC Information Index or UNICORE Registry, are examples that have proven themselves in production environments. Such implementations provide a centralized service registry, however, todays DCIs, such as EGI, are based on a federation model. It is therefore necessary for the service registry to mirror such a model in order for it to seamlessly fit into the operational and management requirements - a DCI built using federated approach. This document presents an architecture for a federated service registry and a prototype based on this architecture, the EMI Registry. Special attention is given to how the federated service registry is robust to environment failu...

  10. Related factors of birth defects%保定地区出生缺陷相关因素研究

    Institute of Scientific and Technical Information of China (English)

    余瑞欣; 侯雯莅; 王建

    2012-01-01

    Objective; To 80 261 cases of perinatal analysis of 889 cases of defective children, most of unknown causes, of which 183 cases had a number of reasons, through the analysis to understand the defects caused by a common cause of children. Methods; The case study method, one by one asked about the history. Results: A number of reasons, such as high fever, contact with a number of chemical raw materials, indiscriminate use of drugs during pregnancy, social factors are all caused by defects. Conclusion; The prevention of pregnancy cold, away from toxic substances, rational drug use and change the bad ideas in order to effectively prevent the occurrence of defects in children.%目的 通过80 261例围产儿分析,缺陷儿889例,大部分不明原因,其中183例有一些明确原因,通过对这些因素分析,了解引起缺陷儿的常见原因.方法 采用个案调查方法,逐一询问病史.结果 一些原因如高烧、接触一些化工原料、孕期乱用药物、社会因素等都是引起缺陷的原因.结论 预防孕期感冒、远离有毒物质、合理用药,改变不良观念从而有效预防缺陷儿的发生.

  11. Tobacco smoking and its consequences on reproductive health: the impact of a lifestyle choices including cigarette smoke exposure on fertility and birth defects.

    Science.gov (United States)

    Merritt, Travis; Mazela, Jan; Merritt, Allen

    2013-01-01

    There are several life style choices which may impact fertility and thus national birth rate. Epidemiological cohort studies indicates that modification of life style habits, among them nicotine consumption can influence reproductive health. Influence of tobacco smoking on reproductive health has to be analyzed within the context of the influence of body mass index, caffeine and alcohol consumption, exercise, maternal and paternal age, and stress. Approximately 27% Polish women and 23% Americans smoke cigarettes during their reproductive years. Cohort studies directly showed the relationship between nicotine consumption and decrease in fertility among smoking women. Besides there is evidence that smoking leads to higher rate of congenital heart defects, limbs abnormalities, central nervous malformations among infants born to smoking mothers. Finally, the relationship between smoking and decreased fertility should be of great concern since Polish fertility rate has dropped from 1989 till 2007 year from 2,1 to 1,27 respectively. Programs focused on improvement in national birth rate should focus also on decrease smoking rates among women.

  12. Meta-analysis on major risk factors of birth defects in China%国内出生缺陷危险因素的 Meta 分析

    Institute of Scientific and Technical Information of China (English)

    赵婵娟; 杜晓玲; 李巧(通讯作者)

    2013-01-01

      目的综合探讨国内出生缺陷发生的危险因素。方法利用 Meta 分析方法综合分析国内2000~2011年间发表的22篇关于出生缺陷发病危险因素的病例对照研究文献,累计病例5238例,对照10571例。结果多因素分析合并比值比(OR)及其95%可信区间(95%CI)分别为:先天畸形家族史3.81(2.48~5.86);孕期感冒发烧3.64(2.16~6.11);孕期病毒感染2.82(2.09~3.82);妊娠合并症3.3(2.59~4.21);孕早期用药4.79(3.14~7.31);孕期服用激素类药物5.39(3.20~9.08);孕期服用镇静止吐药5.22(3.45~7.92);孕期接触有害化学物质3.73(2.87~4.86)等。结论影响国内出生缺陷发生的主要危险因素为先天畸形家族史、孕期感冒发烧、孕期病毒感染、妊娠合并症、孕早期用药、孕期服用激素类药物等。%  Objective To explore the major risk factors of the incidence of birth defects in China. Methods The results of the risk factors of birth defects in 24 epidemiological studies from 2000 to 2011 were analyzed by meta-analysis method. The cumulative cases and controls were 5238 and 10571, respectively. Results The pooled odds ratio(OR) values and 95%CI of various-factor-analysis were as folows: family history of congenital defect was 3.81 (2.48 ~ 5.86); having a fever during pregnancy was 3.64(2.16 ~ 6.11);virus infection during pregnancy was 2.82(2.09 ~ 3.82); complications in pregnancy was 3.3(2.59 ~ 4.21); medicine use in early pregnancy was 4.79(3.14 ~ 7.31);hormone drugs use in early pregnancy was 5.39(3.20 ~ 9.08);sedative and antiemetic drugs use in early pregnancy was 5.22(3.45 ~ 7.92); exposure to damage chemicals in pregnancy was 3.73(2.87 ~ 4.86), et al. Conclusion The major factors influencing the incidence of birth defects in China were family history of congenital defect, had a fever during pregnancy, virus infection during pregnancy, complications in pregnancy

  13. Monitoring results of perinatal birth defects in ChangJi region from 2005 to 2013%2005至2013年昌吉州围产儿出生缺陷监测分析

    Institute of Scientific and Technical Information of China (English)

    马晶; 陈永慧; 朱明福; 吐尔逊江·买买提明; 陈筱萍

    2015-01-01

    Objective To analyze the monitoring results of perinatal birth defects and explore interventions, so as to reduce the incidence of birth defects. Methods Retrospective analysis was conducted on the birth defects monitoring data of 99 150 cases from 2005 to 2013 in Changji region to analyze the incidence of birth defects in different year. Results During 2005-2013, the total incidence of perinatal birth defects was 73. 92/10 000, and it reached peak in 2010. Rising trend was found in 2005-2010, while decline trend was found in 2011 to 2013. The top five birth defects diseases accounted for 67. 37% of all defect types, and they were total cleft lip, more finger (toe), neural tube defects, congenital heart disease and equinus varus in turn. The incidence of birth defects was significantly different regarding nation, urban and rural area, gender, and maternal age (χ2 value was 37. 61, 61. 33, 51. 37 and 59. 46, respectively, all P<0. 05). Conclusion In ChangJi region the incidence of perinatal birth defects is relatively high from 2005 to 2013, which indicates that it is necessary to define the emphasis of prevention and conduct studies on etiology and population distribution of birth defects with high incidence so as to provide evidence for reducing birth defects.%目的:分析围产儿出生缺陷的监测结果,探讨出生缺陷干预措施,降低出生缺陷发生率。方法回顾性分析2005至2013年昌吉州辖区内13家医院99150例围产儿的出生缺陷监测资料,分析不同年份及不同出生缺陷发生的情况。结果2005至2013年昌吉州围产儿出生缺陷总发生率为73.92/万,2010年呈现高峰,2005至2010年成上升趋势,2011至2013年逐年下降。前五位出生缺陷病种占全部缺陷类型的67.37%,依次为总唇裂、多指(趾)、神经管缺陷、先天性心脏病、马蹄足内翻。出生缺陷的发生在民族、城乡、男女性别、孕妇年龄间均存在统计学差异(χ2值分别为37.61、61.33、51

  14. 上海市奉贤区2008-2010年出生缺陷监测%Monitoring analysis on birth defects in Fengxian District of Shanghai from 2008 to 2010

    Institute of Scientific and Technical Information of China (English)

    陈红; 王娟

    2015-01-01

    Objective To investigate the incidence , distribution and trend of birth defects in Fengxian District of Shanghai . [ Methods] The population-based surveillance data of birth defects from 28 gestational weeks to 42 days postpartum was retrospectively analyzed . [ Results] A total of 15 744 perineonates were monitored , in which 277 cases of birth defects were detected .From 2008 to 2010 , the rate of birth defect was 138.94 per 10 000,162.28 per 10 000 and 230.66 per 10 000, respectively, which indicated a rising trend of incidence .The main types of birth defects in turn were congenital heart disease , deformity of external ear , umbilical hernia , synpolydactyly , syndactyly , chilopalatognathus , hemangioma , hydrocephalus , and neural tube defect . [ Conclusion] The rise of birth defects in recent years should be taken seriously . The surveillance and the comprehensive prevention on birth defects should be strengthened .%[目的]了解上海市奉贤区出生缺陷发生情况、分布特征及变化趋势。[方法]采用回顾性分析2008—2010年奉贤区出生缺陷人群监测资料(孕28周至产后42 d)。[结果]监测围产儿总数15744例,缺陷数277例,出生缺陷率分别为138.94/万,162.28/万,230.66/万,3年发生率有上升趋势。主要缺陷种类顺位依次为先天性心脏病、外耳畸形、脐疝、多指(趾)、并指(趾)、唇腭裂、血管瘤、先天性脑积水、神经管缺陷。[结论]近年来出生缺陷率上升需得到重视,应继续加强监测工作,加强出生缺陷综合防控。

  15. Analysis of influencing factors leading to major birth defects in six counties of Shanxi province%山西省六县(市)主要出生缺陷影响因素分析

    Institute of Scientific and Technical Information of China (English)

    张红; 王芳芳; 郭兴萍; 安焕晓; 王钰; 白云

    2012-01-01

    To explore the influencing factors of major birth defects.The children of 0 -3 years and their mother from six different districts were surveyed from November 2009 to December 2009.The incidence rate was 134.27/10 000 (493/36 716)in 6 counties. And the first five birth defects were as follows:congenital heart disease,neural tube defects,cheilopalatognathus,polydactylia and hypophrenia.The risks and protective factors of the first 5 birth defects were different.Anamnesis of birth defects and defective children from relatives,multiple pregnancy & birth and intake of antipyretic analgesics during pregnancy were the common risk factor for the first 5 birth defects.The key points for the prevention of birth defects are to reinforce the pre-pregnancy guidance,the screening and evaluation of risk factors and disease prevention during pregnancy.%为了解山西省主要出生缺陷发生率及其影响因素,于2009年11至12月对山西省6个县(市)0~3岁婴幼儿及母亲进行横断面和回顾性调查.六县(市)出生缺陷发生率为134.27/万(493/36 716);前5位出生缺陷排序为先天性心脏病、神经管畸形、唇腭裂、多指(趾)并指(趾)、智力低下,每种出生缺陷的危险因素和保护因素各有不同,其中亲属缺陷儿史、既往缺陷儿史、孕产次多、孕期服解热镇痛药为其共同危险因素.开展孕前指导、危险因素筛查和评估,孕期预防疾病是预防出生缺陷的关键.

  16. 2000~2009年围产儿出生缺陷相关因素调查分析%SURVEY AND ANALYSIS ON THE RELEVANCE FACTORS OF BIRTH DEFECT OF PERINATAL INFANTS DURING 2000-2009

    Institute of Scientific and Technical Information of China (English)

    孟凡萍; 张新华

    2012-01-01

    [Objective] To acknowledge dynamic change on birth defect occurrence, to provide bases for making decision on drawing up and taking preventive measures. [Methods] According to the monitoring projects of birth defect in China, carried out the monitoring work. [Results) Occurrence rate of birth defect was U.90%o.Tne leading birth defects were neural tube defects, multi-fingers (toes), cleft lip with cleft palate, external ear malformation, other congenital malformation. [Conclusion J It should reinforce health education further, raise awareness of environmental protection and health care, pay attention to the period of gestation and parturition health care, genetic health, premarital health care, continuously improve the level of prenatal diagnosis to prevent and control the birth defects of the population.%[目的]了解出生缺陷发生的动态变化,为制定和采取预防措施提高决策依据.[方法]按照全国出生缺陷监测中心指定的监测方案进行规范地监测.[结果]出生缺陷发生率为11.90‰;出生缺陷前5位依次为神经管畸形、多指(趾)、唇裂合并腭裂、外耳畸形、其他先天畸形.[结论]进一步加强健康教育,提高环保意识和保健意识,做好孕产期保健、优生保健、婚前保健,不断提高产前诊断水平,防止和控制缺陷人口的出生.

  17. Birth defects in Yantai Yuhuangding Hospital during 2006 -2010%2006年-2010年烟台毓璜顶医院围产儿出生缺陷分析

    Institute of Scientific and Technical Information of China (English)

    曲鑫; 刘志芬; 李蕾; 徐爱群; 柳红杰

    2012-01-01

    Objective: To explore the situation, influencing factors, diagnosis of the birth defects in our hospital, so as to provide evidences for periconceptional care. Methods; 301 birth defects in a total of 22211 births were monitored from 2006 to 2010, the birth defect rate was 13. 55% (301/22211). The top 5 common birth defects were Cadiovascular disease, total cleft in lip and palate , synpolydactyly, anephrogenesis or Polycystic kidney and Genital malformation. There was significant difference in birth defect rate between puerperal at city and countryside (x2 = 24. 34, P < 0. 01). There was no significant difference in birth defect rate between puerperal at different age, with different educational status, or different gender of fetus, But, the birth defect rate were higher in the age below 25 and exceed 35 groups than the other group, and the birth defect rate decrease when the educational status of puerperal increase. 48. 17% (145/301 ) cases were confirmed in prenatal diagnosis, and the main method was Ultrasonic Diagnosis. Conclusions: The key to reduce the birth defect rate is the primary prevention. We should improve the quality of antenatal examination and prenatal diagnosis technology, reduce birth defects, and improve the population quality of newborn.%目的 探讨我院围产儿出生缺陷发生状况、影响因素及确诊手段,为探索开展围孕期保健提供依据.方法 对2006年- 2010年5年间在我院住院分娩出生围产儿的监测资料进行回顾性分析.结果 2006年- 2010年我院共出生22211例围产儿,出生缺陷共301例,出生缺陷发生率为13.55‰(301/22211).出生缺陷率位居前五位的分别为先天性心血管疾病、唇腭裂、多指与并指(趾)、单肾缺如及多囊肾、生殖器畸形.产妇城乡间出生缺陷发生率比较差异有统计学意义(x2=24.34,P<0.01).不同年龄、文化程度及胎儿性别比较,差异无统计学意义,但年龄<25岁及≥35岁的产妇其出生缺陷率

  18. Analysis of birth defect in Zhongshan city from 2008 to 2010%中山地区2008年-2010年出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    王莹; 万波; 李莉敏; 胡朝霞; 彭学鸣; 曾冠

    2012-01-01

    目的 了解中山市出生缺陷的发生及分布情况,及时发现影响出生缺陷的可疑因素,协助指导制定相应的干预措施,做好今后出生缺陷监控工作提供科学依据.方法 对2008年-2010年中山市各医院分娩的孕满28周~产后7天内出生的所有围产儿(包括活产、死胎、死产)进行出生缺陷监测,并对其发生率、顺位及诊断依据进行分析.结果 三年内中山市出生缺陷发生率为260.05/万,排位前五位分别是先天性心脏病、多指(趾)、马蹄内翻足、地中海贫血、总唇腭裂.中山市户籍人口和农村、流动人口的顺位和发生率有明显差异.结论 加强流动人口孕产妇的孕期保健管理,普及孕期产前筛查意识,提高出生缺陷产前筛查和产前诊断的准确性,早期发现,早期诊断,早期干预,预防性用药等可减少出生缺陷的发生%Objective: To understand the prevalence of birth defects in Zhongshan, to detect the suspicious factors of influencing birth defects, to divide to provide scientific basis for making countermeasures to prevent and control birth defects. Method; Connecting the all perinatal birth defects data, including fetal deaths, stillbirths, live births, which detected during the second pregnancy over 28 weeks to postnatal day 7, analyzing the incidence rate, the sequence and the basis diagnosis on of birth defects. Results: The incidence of birth defect is 260. 05 per ten thousand in recent three years. The first five birth defect were: congenital heart disease, combined or excessive fingers or toes ( polydactyly) , clubfoot, a- Mediterranean-anaemia, cleft lip and palate. The sequence and the incidence rate of birth defect were significant difference, between Registered population and floating population. Registered population and population in rural areas. Conclusion; In order to depress perinatal birth defect rate, we should pay more attention in not only to the work of education of the

  19. 2001-2010年住院出生缺陷476例临床分析%Clinical analysis of birth defects in 476 cases of hospitalized children from 2001 to 2010.

    Institute of Scientific and Technical Information of China (English)

    祝轲; 任榕娜

    2011-01-01

    Objective To compile the prevalence and factors of birth defects on hospitalized children of Pediatrics in our hospital from 2001 to 2010 and provide some examples for reducing birth defects. Methods Data of birth defects of all hospitalized children from January 1, 2001 to December 31,2010 were reviewed. Types of birth defects and prenatal exposure to risk factors were retrospectively analyzed. Results The prevalence rate of birth defects on hospitalized children over the past 10 years was 16.41 per 1000.The risk factors influencing the incidence of birth defects were the age of parturient under 20 and over 35 , preterm birth (birth less than 37 weeks after conception) ,sick in early pregnancy .taking medicine in early pregnancy, spontaneous abortion, current family history of congenital defect, but the prevalence rates were no significance between urban and suburb and between male and female.Congenital heart diseases were the most common types of birth defects. Conclusion The surveillance and intervention program of birth defects and tertiary preventions shall be performed to decrease preference of birth defects on perinatal fetuses.%目的 统计住院患儿出生缺陷的发生情况及影响因素,为有效预防出生缺陷提供借鉴.方法 收集2001-01-01-2010-12-31南京军区福州总医院儿科住院患儿29015例中发生出生缺陷的病例资料,对患儿出生缺陷构成状况、孕妇多种相关暴露因素进行回顾性分析.结果 10年间南京军区福州总医院儿科住院患儿出生缺陷发生率为16.41‰(476/29015).近4年(2007-2010年)与前6年(2001-2006年)出生缺陷发生率相比(25.24‰对8.83‰),呈明显增高且呈逐年增加趋势,差异有统计学意义(x2=26.30,P<0.05).产妇年龄<20岁和> 35岁、早产(胎龄<37周)、孕早期患病、孕早期用药、有自然流产史、有家族史为出生缺陷发生的危险因素,而城乡、不同性别间出生缺陷发生

  20. Surveillance of birth defect in Xiangshan peninsula in Zhejiang province, 2005-2009%2005-2009年浙江省象山半岛地区出生缺陷监测

    Institute of Scientific and Technical Information of China (English)

    吴美飞

    2011-01-01

    Objective To further understand the incidence of birth defects in Xiangshan and facilitate the implementation of birth defect intervention project. Methods The analysis was conducted on the surveillance data off birth defect detected during pregnancy and 7 days after birth from 1 January 2005 to 31 December 2009 in Xiangshan. Results Totally 24 863 infants were born during this period, the incidence of birth defect was 147. 61/lakh; 170 dead fetuses were detected, 65. 88% of which were caused by fetus defect. The fetus defect detected before and after 28 weeks of gestation accounted for 11. 99% and 88. 01% respectively. The first 5 birth defects were congenital deformity in circulatory system, congenital deformity in musculoskeletal system, congenital deformity of eye, ear, face and neck, congenital deformity in nervous system as well as cleft lip and cleft palate. Conclusion The overall incidence of birth defect increased in Xiangshan during this period. The incidence of fetus defect in dead fetuses was significantly higher than birth defect in live fetuses. The proportion of fetus defect detected before 28 gestation weeks increased by years. It is essential to conduct tertiary prevention of birth defect.%目的 进一步了解象山县出生缺陷发生情况,以利于实施出生缺陷干预工程.方法 监测2005年1月1日至2009年12月31日所有产妇分娩的胎儿在孕期和产后7 d内发现的出生缺陷的相关情况,统一上报,并进行调查、分析.结果 2005-2009年共出生24 863名胎儿,出生缺陷发生率为147.61/万;发生死胎170例,其中缺陷儿死胎占65.88%;孕28周后发现的出生缺陷占88.01%,孕28周前发现的占11.99%;按系统分类排在前5位的分别为循环系统先天性畸形,肌肉骨骼系统先天性畸形和变形,眼、耳、面和颈部先天性畸形,神经系统先天性畸形,唇裂和腭裂.结论 5年出生缺陷发生率总体呈逐年上升趋势,死胎出生缺陷发生率

  1. Assessing the Risk of Birth Defects Associated with Exposure to Fixed-Dose Combined Antituberculous Agents during Pregnancy in Rats

    Directory of Open Access Journals (Sweden)

    O. Awodele

    2012-01-01

    Full Text Available Due to the risks of disease progression and transmission to the newborn, treatment of tuberculosis is often pursued during pregnancy and fixed-dose combined antituberculous agents have been found to be beneficial. Unfortunately, there is paucity of data on the safety of the fixed-dose combined antituberculous drugs during pregnancy. This study intends to assess the teratogenic effect of fixed-dose combined antituberculous drugs on the organogenesis stage of fetal development and also investigate the possible roles of vitamin C in modulating the teratogenic effects of these agents on the fetus using animal model. Pregnant rats were divided into 3 groups with 12 animals per group: group 1 received distilled water (10 mL/kg orally; group 2 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents orally; group 3 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents plus vitamin C (10 mg/kg/day orally. Six rats in each group were randomly selected and sacrificed on day 20 by cervical dislocation prior to day 21 of gestation, and the foetuses were harvested through abdominal incision for physical examination. Blood samples were collected from the 1st filial rats of the remaining six animals for biochemical and hematological examination. The liver, kidney, heart, and brain of all the sacrificed animals were used for histopathological examination. There were significant (≤0.05 low birth weights of the foetuses of the animals that were treated with fixed-dose combined antituberculous agents. The haematological parameters also revealed a reduction in the platelets counts and neutrophiles at the first filial generation. Significant (≤0.05 elevations in the levels of aspartate aminotransferase (AST and alkaline phosphatase (ALP in the foetuses of the animals treated with fixed-dose combined antituberculous agents were also observed. However, the combination of vitamin C with fixed-dose combined antituberculous agents

  2. Assessing the risk of birth defects associated with exposure to fixed-dose combined antituberculous agents during pregnancy in rats.

    Science.gov (United States)

    Awodele, O; Patrick, E B; Oluwatoyin Agbaje, Esther; Oremosu, A A; Gbotolorun, S C

    2012-01-01

    Due to the risks of disease progression and transmission to the newborn, treatment of tuberculosis is often pursued during pregnancy and fixed-dose combined antituberculous agents have been found to be beneficial. Unfortunately, there is paucity of data on the safety of the fixed-dose combined antituberculous drugs during pregnancy. This study intends to assess the teratogenic effect of fixed-dose combined antituberculous drugs on the organogenesis stage of fetal development and also investigate the possible roles of vitamin C in modulating the teratogenic effects of these agents on the fetus using animal model. Pregnant rats were divided into 3 groups with 12 animals per group: group 1 received distilled water (10 mL/kg) orally; group 2 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents orally; group 3 received 51.4 mg/kg/day of fixed-dose combined antituberculous agents plus vitamin C (10 mg/kg/day) orally. Six rats in each group were randomly selected and sacrificed on day 20 by cervical dislocation prior to day 21 of gestation, and the foetuses were harvested through abdominal incision for physical examination. Blood samples were collected from the 1st filial rats of the remaining six animals for biochemical and hematological examination. The liver, kidney, heart, and brain of all the sacrificed animals were used for histopathological examination. There were significant (P ≤ 0.05) low birth weights of the foetuses of the animals that were treated with fixed-dose combined antituberculous agents. The haematological parameters also revealed a reduction in the platelets counts and neutrophiles at the first filial generation. Significant (P ≤ 0.05) elevations in the levels of aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in the foetuses of the animals treated with fixed-dose combined antituberculous agents were also observed. However, the combination of vitamin C with fixed-dose combined antituberculous agents significantly

  3. 闽东地区出生缺陷发展趋势及影响因素研究%Trends and affecting factors of birth defects in Mindong district, Fujian

    Institute of Scientific and Technical Information of China (English)

    林小远; 宋玮婷; 李华; 张凤珍; 林涛; 陈锋萍

    2011-01-01

    Objective To evaluate 10 years trends of birth defects and explore potential affecting factors for the control of the diseases in future. Methods The 2001-2010 surveillance data of birth defects were collected from all hospitals in Ningde, Fujian. A special designed database was developed for the data collection. Statistical analysis was performed with SPSS software. Results Birth defect rate increased from 0. 55% to 1. 1% in 10 years (2001-2010). However, birth defects greater than 28 weeks pregnancy decreased in the same period of time. The most occurred birth defects were congenital heart diseases, cleft lip with and without cleft palate. Ear deformity increased gradually, while congenital hy-drocephalus decreased. In general, birth defects occurred more frequently in male babies than in female babies. Birth defects were associated with the age of mothers. High rates of birth defects were seen in the age groups of mothers between 20 and 25 years as well as over 35 years. Down syndrome and congenital heart diseases increased with the age of mothers. Conclusion Birth defect prevention and medical care in early pregnancy, prenatal screening and diagnosis are essential to decrease birth defects.%目的 为掌握闽东地区的出生缺陷发生的消长情况及影响出生缺陷的可疑因素,为制定干预措施提供依据,进行本研究.方法 按监测方案要求收集2001-2010年宁德市出生缺陷医院监测资料,按要求质量控制,统一统计标准录入SPSS软件建立数据库,进行统计分析.结果 2001-2010年宁德市总出生缺陷发生率呈现上升趋势,≥28周重大出生缺陷发生率呈现下降趋势;主要出生缺陷顺位变化:先天性心脏病升至第一位,总唇裂降至二、三位,外耳其他畸形排序渐升;总唇裂、小耳、先心、马蹄内翻足增高趋势,而先天性脑积水呈下降趋势;男性高于女性;孕母各年龄组之间差异显著,以20~岁组和35~岁组发生率为高;随年

  4. 2000~2010年围产儿出生缺陷监测与分析%Monitoring and analysis on birth defects of perinatal infants from 2000 to 2010

    Institute of Scientific and Technical Information of China (English)

    陈炳兰; 孙丽洲; 田静

    2013-01-01

    Objective: To understand the high risk factors of birth defects in the area by retrospectively analyzing growth and decline of birth defects in the hospital, timely find out suspicious malformation - inducing factors, and provide a basis for carrying out prevention, early diagnosis, and intervention of birth defects. Methods: According to the monitoring project of birth defect in China, the data of parturient women and perinatal infants born in the hospital from 2000 to 2010 were analyzed retrospectively. Results: From 2000 to 2010, a total of 27 838 perinatal infants were monitored, 311 perinatal infants were found with birth defects, the incidence rate was 11. 17%c. The main types of birth defects were polydactyly, congenital heart disease, cleft lip, multi - malformation, digestive tract malformation, hypospa-dias, and hydrocephalus; the incidence rate of birth defects in boys was statistically significantly higher than that in girls; the risk of birth defects among perinatal infants born by parturient women ≥ 35 years old increased significantly, especially among perinatal infants born by parturient women < 20 years old. Conclusion: Enhancing prenatal screening and prenatal diagnosis and raising prenatal detection rate of birth defects can reduce incidence rate of birth defects.%目的:通过回顾分析该院出生缺陷的消长情况,了解该地区出生缺陷的高危高发因素,及时发现可疑的致畸因素,为开展出生缺陷的预防、早期诊断和干预提供依据.方法:依照《中国出生缺陷监测方案》,对2000 ~ 2010年在该院分娩的产妇及其围产儿的资料进行统计分析.结果:11年间共监测围产儿27838例,缺陷儿311例,发生率为11.17‰;主要出生缺陷为指(趾)畸形、先天性心脏病、总唇裂、复合畸形、消化道畸形、尿道下裂、脑积水;男婴出生缺陷发生率较女婴显著增加;产母年龄≥35岁,尤其是产母年龄< 20岁时出生缺陷发生率的危险

  5. Ethical aspects of soft tissue engineering for congenital birth defects in children--what do experts in the field say?

    Science.gov (United States)

    Oerlemans, Anke J M; Rodrigues, Catarina H C M L; Verkerk, Marian A; van den Berg, Paul P; Dekkers, Wim J M

    2010-08-01

    This article is part of the EuroSTEC project, which aims at developing tissue engineering-based treatments for structural disorders present at birth. EuroSTEC is positioned at the intersection of three areas with their own ethical issues: (1) regenerative medicine, (2) research with pregnant women and fetuses, and (3) research with neonates. Because of the overlap of these three areas in this project, we can expect to be confronted with new ethical challenges. To be able to respond adequately and timely to current and possible future ethical issues, a prospective and anticipatory ethical analysis is essential. To obtain a first survey of ethical issues that might arise during the different phases of the project, the Delphi method was used. The professionals directly involved in the EuroSTEC project were questioned about their views on possible ethical issues. The first round yielded 27 ethical issues, which the respondents were asked to prioritize in the second round. For the fundamental research phase, issues deemed most important were privacy and informed consent of the tissue donor. For the animal experimentation phase, three issues were mentioned (in order of decreasing priority): the suffering of animals, the use of animals as means to an end, and the limited adequacy of the animal models. Issues that were deemed most important during the clinical (trial) phase pertained to the problem of weighing risks and benefits for the fetus/child and the pregnant woman.

  6. Risk factors of birth defects in China:a Meta analysis%我国出生缺陷影响因素的M eta分析

    Institute of Scientific and Technical Information of China (English)

    万素馨; 罗亚玲; 周天津

    2015-01-01

    Objective To explore the main risk factors related to birth defects to provide the scientific basis for making the best prevention policy and implementing the effective interventions .Methods Totally 21 domestic research articles on the risk fac‐tors of birth defects were comprehensively analyzed by the meta analysis method ,including accumulated 6 112 patients and 15 741 control cases .The articles were screened preliminarily according to inclusion and exclusion standard ,and then the fixed and random effects model were selected according to the homogeneity test .The merged results were performed the chi‐square test .Results The main merged results OR values of single‐factor‐analysis were as follows:the family history of birth defects 36 .22 ,early pregnant in‐fectious disease 5 .62 ,early pregnancy exposure to chemicals 4 .19 ,paternal smoking 3 .89 ,contact sedatives during pregnancy 3 .19 , pregnancy complication 2 .94 ,high protein food during pregnancy 0 .37 ;the main merged results OR values of multiple‐factor‐analy‐sis were as follows :early pregnancy infectious disease 7 .65 ,poor prenatal mental state 5 .44 ,early pregnancy fever 4 .70 ,early preg‐nancy exposure to toxic chemical 3 .90 ,history of abortion 3 .59 ,supplement of multivitamin during pregnancy 0 .45 .Conclusion The main risk factors of birth defects in our country are family history of birth defects ,early pregnancy infectious disease ,early pregnancy exposure to chemicals ,paternal smoking and pregnancy complication;the protective factors are eating more high protein food during pregnancy ,supplement of multivitamin during pregnancy and taking folic acid during pregnancy .%目的:探讨影响我国出生缺陷发生的主要危险因素,为制定最佳预防控制决策、实行有效的干预措施提供科学依据。方法利用M eta分析方法综合分析国内关于出生缺陷发病危险因素的研究文献21篇,累计病例6112例,对照15741例。据纳

  7. 180例出生缺陷儿危险因素分析%Analysis of risk factors of birth defect in 180 cases

    Institute of Scientific and Technical Information of China (English)

    季静敏; 鲁巧珍; 何萍; 黄璧琨

    2012-01-01

    Objective To analyze the risk factors of birth defect ( BD ). Methods With case-control method 180 cases with birth defect and 180 normal newborns were selected through the medical history review. The differences in maternal age, maternal occupation, first check gestational age, medical history at early stage of pregnancy, antenatal examination times, drug use at pregnant period, pregnancy complications, history of abnormal pregnancy and delivery, family history of congenital defects, history of exposing to toxic and harmful substances, paternal age, paternal occupation and etc. Between them were analyzed. Results Univariate analysis revealed that five factors were different between case group and control group: the average age of mother ( t = 3. 255, P = 0. 001 ), the average age of father( t= 2.047, P = 0.041 ), maternal occupation(χ2= 11. 016, P =0. 026 ), history of abnormal pregnancy and delivery (χ2 =5. 767, P = 0.016), and family history of congenital defects (χ2 = 4. 405 , P = 0.044 ). Multivariate logistic analysis showed that maternal occupation ( education ) was protective factor. Conclusion BD is caused by complicated factors, including age of parents, maternal occupation, history of abnormal pregnancy and delivery and family history of congenital defects.%目的 分析引起出生缺陷儿的危险因素.方法 用病例对照的研究方法,比较分析180例出生缺陷儿(其中133例活产缺陷儿、47例引产缺陷儿)与180例出生正常儿的母亲年龄、母亲职业、初次孕检孕周、孕早期疾病史、产前检查次数、妊娠期用药、妊娠合并症并发症、异常孕产史、缺陷家族史、接触有毒有害物史、父亲年龄、父亲职业等因素的差异.结果 单因素分析显示以下5个因素在病例组和正常组之间存在显著性差异:母亲平均年龄(t=3.255,P=0.001)、父亲平均年龄(t=2.047,P=0.041)、母亲职业(χ2=11.016,P=0.026)、异常孕产史(χ2=5.767,P=0.016)

  8. Autosomal and X chromosome structural variants are associated with congenital heart defects in Turner syndrome: The NHLBI GenTAC registry.

    Science.gov (United States)

    Prakash, Siddharth K; Bondy, Carolyn A; Maslen, Cheryl L; Silberbach, Michael; Lin, Angela E; Perrone, Laura; Limongelli, Giuseppe; Michelena, Hector I; Bossone, Eduardo; Citro, Rodolfo; Lemaire, Scott A; Body, Simon C; Milewicz, Dianna M

    2016-12-01

    Turner Syndrome (TS) is a developmental disorder caused by partial or complete loss of one sex chromosome. Bicuspid aortic valve and other left-sided congenital heart lesions (LSL), including thoracic aortic aneurysms and acute aortic dissections, are 30-50 times more frequent in TS than in the general population. In 454 TS subjects, we found that LSL are significantly associated with reduced dosage of Xp genes and increased dosage of Xq genes. We also showed that genome-wide copy number variation is increased in TS and identify a common copy number variant (CNV) in chromosome 12p13.31 that is associated with LSL with an odds ratio of 3.7. This CNV contains three protein-coding genes (SLC2A3, SLC2A14, and NANOGP1) and was previously implicated in congenital heart defects in the 22q11 deletion syndrome. In addition, we identified a subset of rare and recurrent CNVs that are also enriched in non-syndromic BAV cases. These observations support our hypothesis that X chromosome and autosomal variants affecting cardiac developmental genes may interact to cause the increased prevalence of LSL in TS. © 2016 Wiley Periodicals, Inc.

  9. 早产对脑性瘫痪儿童乳牙釉质发育的影响%The developmental enamel defects in the primary dentition of cerebral palsied children with premature birth

    Institute of Scientific and Technical Information of China (English)

    林小波; 张笋; 吴卫红; 吴志文

    2011-01-01

    目的 研究早产因素对脑瘫儿童乳牙釉质发育缺陷的影响.方法 选择135名脑瘫患儿,与62名正常儿童对比,进行乳牙釉质发育缺陷状况的统计调查.同时比较脑瘫儿童中早产与乳牙釉质发育缺陷发生的关系.结果 脑瘫儿童组中早产儿童乳牙釉质发育缺陷的患病率明显高于足月组,有统计学差异(P<0.05).结论 早产的脑瘫儿童更容易发生乳牙釉质发育缺陷.%Objective To investigate the developmental enamel defects in the primary dentition of cerebral palsied children with premature birth. Methods One hundred and thirty-five children with cerebral palsy were examined for the clinical manifestation of the developmental enamel defects in the primary dentition. The relationship between the defects and cerebral palsied children's birth conditions were assessed. Results The prevalence of enamel defects in cerebral palsied children born premarurely was significantly higher than that in those with full term birth. Conclusion Enamel defects in the primary dentition are more likely to happen in cerebral palsied children with premature birth than those with full term birth.

  10. 龙岗区2004~2009年出生缺陷监测资料分析%Analysis on monitoring data of birth defects in Longgang district from 2004 to 2009

    Institute of Scientific and Technical Information of China (English)

    张绍强; 张玲; 邹丹玲; 陈文英; 夏洪波

    2012-01-01

    目的:了解近几年深圳市龙岗区围产儿出生缺陷发生率及变化趋势,为降低出生缺陷发生率、提高出生人口素质提供依据.方法:对2004~2009年出生缺陷监测资料进行回顾性分析.结果:2004~2009年龙岗区围产儿出生缺陷发生率为13.05‰,流动人口出生缺陷发生率高于常住人口;男性围产儿出生缺陷发生率为14.15‰,女性发生率为11.50‰,男性出生缺陷发生率比女性发生率高;常见出生缺陷类型为先天性心脏病、多指(趾)及总唇裂;出生缺陷中的死胎、死产导致死亡构成比呈下降趋势(x2=38.19,P <0.0001),新生儿存活构成比则呈上升趋势(x2=36.65,P<0.0001).结论:积极开展三级预防,采取综合干预措施,降低出生缺陷的发生率.%Objective: To understand the incidence and change trend of perinatal birth defects in Longgang district of Shenzhen cit-y in recent years, provide a basis for reducing the incidence of birth defects and improving the quality of birth population. Methods: The monitoring data of birth defects in Longgang district from 2004 to 2009 were analyzed retrospectively. Results; From 2004 to 2009, the incidence of birth defects in Longgang district was 13. 05%o, the prevalence of birth defects of floating population was higher than that of permanent resident population; the incidences of birth defects of male perinatal infants and female perinatal infants were 14. 15%o and 11. 50%e, respectively , the incidence of birth defects of male perinatal infants was higher than that of female perinatal infants; the common types of birth defects included congenital heart disease, polydactyly, cleft lip or/and cleft palate. The proportion of perinatal death induced by fetal death and stillbirth showed a decreasing trend (x2 =38. 19, P <0. 000 1 ) , the proportion of survival neonates showed a increasing trend (x2 = 36. 65, P <0. 000 1) . Conclusion; Carrying out tertiary prevention actively and adopting

  11. Investigation on birth defects of the newborn from 2006 to 2010 in Huangshan City, Anhui Province%2006~2010年安徽黄山市新生儿出生缺陷调查

    Institute of Scientific and Technical Information of China (English)

    杨怡; 章世妹; 胡红喜

    2013-01-01

    Objective To understand the birth defects of children aged 0—5 who were born during the 11th Five-Year Plan (from 2006 to 2010), and explore the risk factors of birth defects in the region. Methods The children aged 0~5 were screened in Huangshan City, and the children diagnosed with birth defects by screen or clinical examination were chosen as investigation objects, and the epidemiological factors were investigated and analyzed. Results A total of 61842 children were screened, and 981 of which were cases with birth defects, the incidence of birth defects was 158.63/ten thousand. The top 5 were congenital heart disease, limb malformations, total cleft lip and palate, cerebral atrophy and congenital hydrocephalus, respectively. The incidence of birth defects was significant different in maternal ages and birth regions. Conclusion The distribution characteristics of birth defects in this region indicates that the birth defects are closely related to the age of the pregnant women , the education conditions and the infection during pregnancy as well . The protection in the early pregnancy will play a significant role to prevent the birth defects.%目的 了解黄山市"十一五"期间(2006~2010 年)出生的0~5 岁新生儿出生缺陷的现况,探讨黄山地区人群出生缺陷的危险因素.方法 采用流行病学筛查方法,以黄山地区的0~5 岁儿童为筛查对象,对筛查出的具有明确诊断或经临床体检诊断出的出生缺陷儿作为调查对象,对人群出生缺陷流行因素进行调查分析.结果 共调查61842 人,筛查出生缺陷儿981 例,出生缺陷发生率为158.63/万.排在前5 位的是先天性心脏病、肢体畸形、总唇腭裂、脑萎缩和先天性脑积水.对比不同生育年龄产母、不同出生地区出生缺陷率,差异均有统计学意义.结论 本次结果 显示孕妇的年龄、文化程度、以及孕期感染等与新生儿出生缺陷有关.孕早期保护对于预防新生儿出生缺陷

  12. 0~1岁婴儿出生缺陷的流行病学调查%Epidemiological survey on 0-1 years old baby with birth defect

    Institute of Scientific and Technical Information of China (English)

    倪少义; 何洁壁; 陈少娜; 吴翔; 蔡幸生; 黄伟鹏; 王榕生; 洪艳苹; 倪少英; 卢晓航

    2012-01-01

    Objective To understand the incidence of birth defect in 0-1 years old baby in some regions of Jieyang, then to determine the focus groups for prevention. So that it can provide a foundation for birth defect prevention, pre-pregnancy and pregnancy care. Methods Those babies, who were born in Jiedong County, Puning City and Rongcheng District from March 3, 2011 to May 2, 2012 were surveyed by general investigation. Birth defect based on clinical diagnosis, its entity and statistical standard referred to the regulations of International Centre on Birth Defects and Prematurity. Results 238 cases of birth defect babies were found out of 10 773 cases of monitored new babies. The top five diseases of baby birth defects were congenital heart disease, talipes equinovarus, polydactyly, cleft lip and palate and fetal-edematous-syndrome. Some babies had higher incidence of birth defects, such as baby boy, low birth weight baby, and those babies whose mother did not take folic acid, vitamin and trace elements during pregnancy and whose family members smoking and excessive drinking (P < 0.05). Conclusion The incidence rate of birth defects in 0-1 years old baby is 220.92 per ten thousand in some regions of Jieyang City. It is slightly higher than the national average, so it needs attention from each side. Strengthening propaganda and education, screening and preventing birth defects are matters of great urgency.%目的 了解揭阳部分地区0~1岁婴儿出生缺陷的发病情况,确定预防的重点人群,为出生缺陷的预防和孕前、孕期保健提供依据.方法 采用普查的方式,对揭东县、普宁市、榕城区三地2011年3月3日~2012年5月2日出生的婴儿进行调查.出生缺陷以临床诊断为依据,病种及统计标准参照国际出生缺陷监测情报交换所的规定.结果 共监测10 773名婴儿,发现出生缺陷238例;婴儿出生缺陷排名前5位的疾病分别是先天性心脏病、马蹄内翻足、多指(趾)、唇(腭)裂

  13. Relationship of Birth Defects with Electromagnetic Radiation and Food Chain%出生缺陷与电磁辐射和食物链关系分析

    Institute of Scientific and Technical Information of China (English)

    苏花莉; 夏红卫; 韦红卫; 黄卫民; 孔琳; 黄琳

    2014-01-01

    Objective To investigate the relationship of birth defects with electromagnetic radiation and food chain.Methods One hundred and ninety-five mothers who had infants with birth defects were selected as study group ,and 195 mothers who had healthy infants were selected as control group .An investigation was conducted on the aspects of living environment ,the frequency of using mobile phone ,computer ,electromagnetic oven or microwave oven , and diet habit during pregnant period .The levels of estrogen ,gestagen and testosterone in maternal blood were detected after delivery .Results The mothers in the study group living near the electric transformer ,TV tower or communication transmission tower were more than those in the control group (all P<0.05),the frequencies of mothers′eating artificial feeding fowl,livestock or fish during pregnant period of study group were higher those of control group (all P<0.05). The frequencies of mothers′using mobile phone ,computer ,electromagnetic oven ,microwave oven or watching TV during pregnant period of study group were higher than those of control group (all P<0.05).Conclusion Electromagnetic radiation and eating artificial feeding fowl ,livestock and fish might have influence on birth defects .%目的:探讨出生缺陷与电磁辐射和食物链的关系。方法选择195例出生缺陷患儿母亲作为研究组,195例健康儿母亲为对照组,对两组孕期居住环境及使用手机、电脑、电磁炉、微波炉频率和饮食习惯等进行调查,并检测分娩时母血雌激素、孕酮、睾酮水平。结果研究组居住靠近变压器、电视塔、通讯转播塔比例高于对照组(P均<0.05),孕期食用人工饲料喂养的家禽、牲畜、鱼等的频率高于对照组(P均<0.05);研究组孕期使用手机、电脑、电磁炉、微波炉、观看电视的频率高于对照组( P均<0.05)。结论电磁辐射和食用人工饲料喂养的家禽、牲畜、鱼类

  14. 湖南省2009-2011年围产儿出生缺陷监测结果分析%Analysis on Monitoring Results of Perinatal Birth Defects in Hunan from 2009 to 2011

    Institute of Scientific and Technical Information of China (English)

    王爱华; 杜其云

    2013-01-01

    目的 分析围产儿出生缺陷监测结果,探讨出生缺陷干预措施,降低出生缺陷发生率. 方法 对2009-2011年围产儿出生缺陷医院监测资料用SPSS软件进行统计分析. 结果 监测293 053例围产儿中,出生缺陷发生数5 766例,出生缺陷发生率为196.76/万,3年出生缺陷率差异有统计学意义(P<0.05).前5位出生缺陷依次为:先天性心脏病、外耳其他畸形、多指(趾)、马蹄内翻足、唇裂合并腭裂.出生缺陷发生城市高于农村、孕母分娩无明显的季节分布、大于35岁组母亲出生缺陷发生率明显高于其他年龄组、男婴高于女婴. 结论 加强孕前、孕早期保健宣传,开展产前筛查、产前诊断和新生儿疾病筛查工作,避免和减少出生缺陷发生,提高出生人口素质.%Objective To analyze the monitoring results of perinatal birth defects and explore the interventions so as to reduce the incidence of birth defects. Methods SPSS software was used to analyze the monitoring data about birth defects among hospitals in Hunan from 2009 to 2011. Results A total of 293,053 perinatal infants were monitored. Birth defects occurred in 5,766 perinatal infants, and the incidence rate of birth defects was 196.76/10,000. There were statistically significant differences in the incidence rate of birth defects among the three years (P 35 years was significantly higher than those of other age groups. More male infants were involved than the female. Conclusions It is necessary to enhance health care propaganda before getting pregnant and during the early stages of pregnancy and popularize prenatal screening, prenatal diagnosis, and neonatal screening so as to avoid and reduce abnormal infants and improve the quality of births.

  15. Case-control study on influencing factors of perinatal birth defects%围产儿出生缺陷影响因素的病例对照研究

    Institute of Scientific and Technical Information of China (English)

    李媛媛; 张海鲲; 李忠良; 翟庆峰

    2011-01-01

    目的 探寻围产儿出生缺陷的影响因素,为出生缺陷干预提供科学依据.方法 按照1:1配对的原则选取出生缺陷围产儿和健康围产儿各807例,用单因素与多因素Logistic回归分析筛选出生缺陷的主要影响因素.结果 婚前参加体检,经常食用鱼虾肉蛋类、牛奶豆类食物等为出生缺陷的保护性因素;父母近亲结婚、家庭附近有污染、孕育期用药、孕育期接触有害物质、有生育畸形儿史、母亲吸烟饮酒为出生缺陷的危险因素.结论 出生缺陷干预可从控制环境有害因素、加强孕期营养保健、指导孕期合理用药、减少吸烟饮酒等不良行为生活方式、提倡婚前体检等方面综合入手.%Objective; To explore the influencing factors of perinatal birth defect. Methods; According to the birth date and sex matching principle, selected 807 perinatal birth defects infants and 807 normal infants. The influencing factors of perinatal birth defect were filtered with the Logistic regression analysis. Results: Regular intake of fish, shrimp, meat, eggs, milk, and beans during pregnancy , participating in pre-marital medical examination were the protective factors of birth defects. Consanguineous marriage, environment pollution sources near residence, suffering from chronic diseases before or during pregnancy, maternal exposure to occupational risk factors before or during pregnancy, abnormal reproductive history, and the habit of drinking and smoking were the risk factors of birth defects. Conclusion; To reduce infant birth defect incidence and improve national body diathesis, we must protect from environment risk factors, enhance pregnant nutrition, quit smoking and drinking, and advocate the premarital examination.

  16. 孝感市2007~2011年围产儿出生缺陷流行病学调查%Study on perinatal birth defects from 2007 to 2011 in Xiaogan City

    Institute of Scientific and Technical Information of China (English)

    邱越; 陆敏; 杨树杰; 刘景丽; 付汉东; 彭红华; 李君; 罗红英; 余小艳

    2013-01-01

    OBJECTIVE To master the epidemiology of birth defect in Xiaogan City,analysis the dynamic trends and try to find out the main factors that may affect birth defects so as to develop effective preventive measures to improve the quality of newborn births.METHODS All the perinatal birth defects monitoring data of year 2007-2011 that in all the midwifery unit of Xiaogan were collected by child birth defects registration card and analyzed retrospectively.RESULTS Five-year birth defects incidence was 4.26‰ and the rates among the 5 years had no statistic difference (P> 0.05).The common birth defects in the top five were multi-finger polydactyly (0.61‰),external ear malformation (0.47‰),cleft lip with cleft palate (0.45‰),cleft lip (0.39‰) and congenital heart disease (0.32‰).Prenatal diagnosis rate was 21.08%,of which B-ultrasound diagnosis was 14.46%.Age of the maternal was a factor to birth defects that when the mother was older than 35 or younger than 20 the incidence of birth defects was obviously higher than other age group.Male birth defects rate were higher than females.The defects rate in countries was higher than that in towns.There was a positive relationship between the maternal education level or lower household income and rate of perinatal birth defects.CONCLUSION The main birth defects in Xiaogan of the last five years are the surface defects and the high risk factor of the birth defects are mother age,education level,economic level and place of residence.The rural areas are the focus to make prevention.So we should strengthen promotion of marriage and pregnancy health and improve prenatal diagnostic techniques so as to reduce the incidence of birth defects effectively.%目的 掌握孝感市围产儿出生缺陷的流行病学特征,分析主要出生缺陷的高危因素,制定有效的预防措施,提高出生人口的素质.方法 采用《出生缺陷儿登记卡》收集孝感市所有助产技术单位2007~2011年围产儿出生

  17. The Virtual Observatory Registry

    CERN Document Server

    Demleitner, Markus; Sidaner, Pierre Le; Plante, Raymond L

    2014-01-01

    In the Virtual Observatory (VO), the Registry provides the mechanism with which users and applications discover and select resources -- typically, data and services -- that are relevant for a particular scientific problem. Even though the VO adopted technologies in particular from the bibliographic community where available, building the Registry system involved a major standardisation effort, involving about a dozen interdependent standard texts. This paper discusses the server-side aspects of the standards and their application, as regards the functional components (registries), the resource records in both format and content, the exchange of resource records between registries (harvesting), as well as the creation and management of the identifiers used in the system based on the notion of authorities. Registry record authors, registry operators or even advanced users thus receive a big picture serving as a guideline through the body of relevant standard texts. To complete this picture, we also mention comm...

  18. The virtual observatory registry

    Science.gov (United States)

    Demleitner, M.; Greene, G.; Le Sidaner, P.; Plante, R. L.

    2014-11-01

    In the Virtual Observatory (VO), the Registry provides the mechanism with which users and applications discover and select resources-typically, data and services-that are relevant for a particular scientific problem. Even though the VO adopted technologies in particular from the bibliographic community where available, building the Registry system involved a major standardisation effort, involving about a dozen interdependent standard texts. This paper discusses the server-side aspects of the standards and their application, as regards the functional components (registries), the resource records in both format and content, the exchange of resource records between registries (harvesting), as well as the creation and management of the identifiers used in the system based on the notion of authorities. Registry record authors, registry operators or even advanced users thus receive a big picture serving as a guideline through the body of relevant standard texts. To complete this picture, we also mention common usage patterns and open issues as appropriate.

  19. Analysis of birth defects monitoring data from 2009 to 2013 in Liuzhou City%柳州地区2009至2013年围产儿出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    刘静; 农铮; 邱萍; 覃海研; 关海滨; 刘成娟; 张玉; 林墨菊

    2014-01-01

    目的:了解柳州市出生缺陷发生的变化趋势及流行病学特征,为开展出生缺陷病因研究及制订出生缺陷综合干预措施提供参考依据。方法对2009~2013年柳州市范围内119家助产医院的围产儿出生缺陷监测资料进行统计分析。结果5年共监测围产儿239343例,发现出生缺陷儿4324例,出生缺陷总发生率为18.07‰,整体呈现上升趋势(χ2趋势=44.393,P<0.001)。出生缺陷发生率前5位顺位依次是先天性心脏病、多指/趾、外耳其他畸形、总唇裂、马蹄内翻足。缺陷发生率城镇(22.36‰)高于农村(14.94‰,(χ2=194.909,P<0.001);男性(20.34‰)高于女性(15.33‰)(χ2=84.584,P<0.001)。结论柳州市出生缺陷发生率处于较高水平,应有针对性的进一步加大出生缺陷的一、二级预防措施,加强优生优育宣传,提高孕前产前检查,以减少出生缺陷的发生与出生,提高人口素质。%Objective To analyze the variation and epidemiologic features of birth defects in Liuzhou City , so as to provide basis for analyzing etiology of birth defects and making interventional measures .Methods SPSS 13.0 software was used for statistical analysis of monitoring data of birth defects in 119 obstetric hospitals in Liuzhou city from 2009 to 2013.Results Totally 4 324 infants with birth defects were found among 239 343 perinatal infants, and the incidence was 18.07‰with an increasing trend ( χtrend2 =44.393, P<0.001).The top five in the sequence of birth defects was congenital heart disease , multiple fingers/toes, other outer ear deformities , total cleft lip and horseshoe varus foot.Incidence of birth defects in town (22.36‰) was higher than in countryside (14.94 ‰) (χ2 =194.909,P<0.001), and that of the male (20.34‰) was higher than the female (15.33‰) (χ2 =84.584,P<0.001).Conclusion The incidence of birth defects maintains

  20. 肇庆市2001-2010年围产儿出生缺陷监测资料分析%Data analysis of perinatal and infants with birth defects from 2001 to 2010 in Zhaoqing county

    Institute of Scientific and Technical Information of China (English)

    陈志玮; 刘楚芹; 梁云

    2012-01-01

    Objective To find out the incidence of birth defects and its variation in four hospitals of Zhaoqing, and to investigate the risk factors that causing birth defects, in order to provide references for formulating intervention measures. Methods According to the requirements of "Monitoring planning of birth defects in hospitals of Guangdong province", four hospitals in Zhaoqing were chosen for this investigation, and statistical analysis methods were used to analyze the birth defects data from 2001 to 2010 in Zhaoqing. Results 63 476 perinatal and infants were observed from 2001 to 2010, and 1 043 infants were found to have birth defects, and the incidence was 162.9 per ten thousand. There was an upward trend in general, and the incidence in 2010 was significantly higher than that in 2001 (χ2=21.635,P<0.001). The top three types of birth defects were congenital heart disease, fetal edema syndrome, and polydactyly malformation. Incidence of birth defect was associated with the sex, maternal age, and fetus number. Conclusion Birth defects have a great impact on the quality of the population, and the third class preventive measure should be continually strengthened to reduce the birth defects.%目的 了解肇庆市4家监测医院出生缺陷儿的发生率及其变化情况,研究出生缺陷发生的相关因素,为制定出生缺陷干预措施提供依据.方法 按照《广东省出生缺陷医院监测方案》的要求,以市内4家医院作为监测医院,对肇庆市2001-2010年的出生缺陷监测资料进行回顾性分析.结果 2001-2010年共监测围产儿63476名,其中出生缺陷儿1 034名,发生率为162.90/万,总体呈上升趋势,2010年的发生率比2001年高,差异有统计学意义(x2=21.635,P<0.001).前3位出生缺陷类型依次为先天性心脏病、胎儿水肿综合征、多指(趾)畸形.出生缺陷发生率与围产儿性别、孕母年龄、胎数有关.结论 出生缺陷严重影响出生人口的素质,应继续加强三

  1. 珠海市2011~2013年围产儿出生缺陷监测结果分析%Analysis on Monitoring Data of Birth Defects in Zhuhai City from 2011 to 2013

    Institute of Scientific and Technical Information of China (English)

    贝伟红; 戚小兵; 伍平; 黄斯娜; 于春荣; 郭胜男

    2014-01-01

    Objective To study the epidemic trends and distribution characteristics of birth defects in Zhuhai city from 2011 to 2013 ,and analyze the main relevant factors ,which could provide basic information for making prevention measures to reduce the incidence of birth defects.Methods The data of perinatal birth defects from all monitoring institutions in Zhuhai city from 2011 to 2013 were analyzed retrospectively.Results The incidence of birth defects was 16.23‰ in Zhuhai city from 2011 to 2013 with an increasing trend. The top five types of birth defects were heart disease ,polydactyly ,syndactylia ,talipes equinova‐rus ,and cleft lip with cleft palate. The prevalence rate of birth defects was significantly higher in urban and among boys(both P<0.01).The incidence of birth defects was relatively high for puerperas over 35 years(22.81‰)and those younger than 20 years old(17.21‰). The proportion of the live birth defects and the prenatal diagnosis was 83.88% and 18.76% ,respective‐ly.Clinical diagnosis and ultrasound were the main diagnostic methods.Conclusion A well‐planned monitor system ,tertiary prevention strategy and comprehensive interventional measures are sensible ways to lower the incidence of birth defects.%目的:了解珠海市2011~2013年围产儿出生缺陷的流行趋势及分布特点,并对出生缺陷的主要相关因素进行分析,为制订出生缺陷的预防措施提供依据。方法对珠海市2011~2013年所有监测机构的围产儿出生缺陷资料进行回顾性分析。结果珠海市2011~2013年间围产儿出生缺陷发生率为16.23‰,有逐年上升趋势( P<0.01);前5位出生缺陷类型依次为先天性心脏病、多指(趾)、并指(趾)、马蹄内翻足、唇裂合并腭裂;男性围产儿的出生缺陷发生率高于女性围产儿的发生率(P<0.01);城镇人口的出生缺陷发生率明显高于乡村(P<0.01)。产妇年龄大于35岁和小于20岁年龄组

  2. Facility Registry Service (FRS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Facility Registry Service (FRS) provides an integrated source of comprehensive (air, water, and waste) environmental information about facilities across EPA,...

  3. 重庆市涪陵区311例围生儿出生缺陷分析%Birth defects analysis of 311 perinatal infants at Fuling district in Chongqing

    Institute of Scientific and Technical Information of China (English)

    刘明会; 薛莹; 李红

    2015-01-01

    Objective To investigate the current status and change tendency of birth defects in the region to provide ref-erence for formulating reasonable prevention measures against birth defect. Methods A total of 311 monitoring data of birth de-fect from the hospitals including Fuling Central Hospital ,Puling Women and Children Health Care Hospital and Puling People′s Hospital from October 1,2010 to September 30,2013 at Fuling district in Chongqing were analyzed retrospectively,understanding the occurrence of birth defect,defect rate change trend as well as the related factors and birth defects (defects gender,age,residence and education level of lying-in women,etc.). Results Birth defect rate from the three monitoring organs of this region was de-creased annually. The occurrence of birth defects in 2013,accoutning for 1.846%(120/6 501),was significantly lower than that 2.046%(88/4 301) in 2011,whose difference had statistically significance(P0.05). The incidence of birth defect of the women aged less than 20 years old or over 35 years old were both higher than that of the women aged 20-35 years old. The lying-in women graduated from junior middle school or below had a higher occurrence in birth defect,and the difference had statistical significance(P<0.05). The prenatal diagnosis of birth defects,with the diagnostic rate of 21.54%(63/311) only,gave priority of ultrasonic diagnosis and chromo-some examination . Conclusion Paying attention to the occurrence of relevant factors of birth defect and improving the prenatal diagnosis of birth defects rate may effectively reduce the incidence of birth defect.%目的:探讨重庆市涪陵区出生缺陷儿的现状和变化趋势,为制订适合当地出生缺陷防治措施提供参考。方法选取该地区涪陵中心医院、涪陵区妇幼保健院、涪陵区人民医院3家监测机构2010年10月1日至2013年9月30日分娩的311例出生缺陷儿监测资料进行回顾性分析,了解出生缺陷发生率的

  4. Mortalidad por defectos al nacimiento en menores de 5 años de edad en México de 1998 a 2006 Birth defects mortality in five-year-old minors of age, Mexico, 1998-2006

    Directory of Open Access Journals (Sweden)

    Javier Valdés-Hernández

    2009-10-01

    Full Text Available OBJETIVOS: Analizar la mortalidad por defectos al nacimiento (DAN entre 1998 y 2006. Seleccionar los municipios con alta mortalidad en OBJECTIVE: To analyze mortality due to birth defects from 1998-2006. To select municipalities with high mortality among children under 5 years of age. MATERIAL AND METHODS: The source of information was mortality records from vital statistics collected by SSA/INEGI. We used the 2005 Municipal Geostatistical Framework by INEGI and SIGEPI for the spatial analysis. The selection criteria were municipalities with 80% and over of deaths due to birth defects. RESULTS: Deaths diminished 8% during 1998-2006 and rates decreased 20%. A total of 42.57% - 48% of deaths are due to circulatory system defects and 13.69% - 19.39% are due to the nervous system; the former rose 4% and the latter fell 32%. Eighty percent or more occur in children under 5 years and the rate in this group fell 8.63%. A total of 1 025 (41.82% municipalities are priorities, 104 (10.14% are high and 102 (9.95% are very high priorities, where 66% of deaths occur among children under 5 years old. DISCUSSION: The interventions to decrease mortality due to birth defects should be directed towards one-year-old children (75% and towards 8.4% of the municipalities that are a very high priority, since they represent 66% of the deaths.

  5. A STUDY ON PREVAL E NCE OF BIRTH DEFECTS AND ITS ASSOCIATION WITH RISK FACTORS IN FAKHRUDHIN ALI AH MED MEDICAL COLLEGE AND HOSPITAL

    Directory of Open Access Journals (Sweden)

    Alpana

    2015-07-01

    Full Text Available OBJECTIVE: Congenital anomalies or Birth Defects are a global problem. It is the most common cause of disability in developed and developing countries. This study aims to evaluate the overall prevalence of clinically detectable congenital anomalies in newborns along with the different forms of congenital anomalies and associated risk factors if any over a period of one year. MATERIALS AND METHOD S: I t’s an observational analytical cross sectional type of study. Seven thousand seven hundred and ninety eight babies born during the period from 1 st Nov, 2013 to 31 st Oct, 2014 were analyzed. Details of cases were recorded after parent’s interviews, clinical, radiological and laboratory evaluations. RESULTS: In our study, we have found that out of the total no. of 7798 babies born during the said period, the total number of congenital anomalies found were 53 0.7%. Cleft lip and palate was the most common anomaly followed by clubfoot. System wise, congenital anomaly of the musculoskeletal system was the highest (45.3%. A male preponderance is seen with M:F = 4:3. Maximum number of anomalies was found in the 20 - 25 y rs of age group. Moreover, anomalies were found more in primi gravida. Various risk factors were associated in 9 numbers of cases out of 53. CONCLUSIONS: Prevalence of congenital anomaly was found to be 0.7% and therefore awareness about preventable risk f actors should be created and early prenatal diagnosis and management of anomalies is recommended.

  6. 叶酸补充在出生缺陷一级预防措施中的应用%Use of folic acid in the primary prevention of birth defects

    Institute of Scientific and Technical Information of China (English)

    何晓蓉

    2013-01-01

      to eliminate the cause of diseases, prevent the occurrence of birth defects and improve the quality of newborns.Approach:Giving 1480 cases of women at childbearing age from pre-pregnancy or early stage of pregnancy a small dose of folic acid tablets"Serianen", as well as educational materials about the prevention of birth defects and eugenic trainings from January 2008 to December 2010.Results: the follow-up surveys on the 1480 cases of women after childbirth show, that non of their newborns has got birth defects such as neural tube defect or congenital heart disease, which means the preventive measures are 100% effective.Conclusion: Folic acid can effectively prevent birth defects such as neural tube defect and congenital heart disease. At the same time, the key of prevention of birth defects lies in taking primary preventive measures.%  目的:探讨叶酸补充在出生缺陷一级预防措施中的应用价值,预防出生缺陷的发生,提高人口出生素质。方法:2008年1月至2010年12月,让我区1480例准备生育的育龄女性从孕前及怀孕早期开始服用小剂量的叶酸增补剂斯利安,并为她们发放预防出生缺陷的宣传资料,对其进行分期优生培训。在1480例女性产后1个月至1年对其进行追踪调查。结果:调查结果显示,本组1480例女性所产小儿无一例发生神经管畸形及先天性心脏病等出生缺陷,预防出生缺陷的有效率为100%。结论:补充叶酸能有效地预防神经管畸形及先天性心脏病等出生缺陷。预防出生缺陷的关键在于采取一级预防措施。

  7. Prevalence of birth defects in the Tongzhou District of Beijing between 2006 and 2012%2006 ~ 2012年北京市通州区出生缺陷患病率的动态变化

    Institute of Scientific and Technical Information of China (English)

    郁静茹; 金蕾; 肖利华; 靳蕾

    2014-01-01

    目的:了解北京市通州区2006~2012年出生缺陷患病率的变化趋势和流行特征,为出生缺陷预防提供参考依据。方法依据2006~2012年北京市通州区出生缺陷监测系统资料,对出生缺陷的患病率及变化趋势等进行统计学分析,同时计算出生缺陷产前检出比例。结果7年间共监测到活产儿92340例,出生缺陷儿1165例,患病率为12.62‰,呈上升趋势(χ2=6.77,P<0.01)。户籍人口的出生缺陷患病率(11.55‰)低于流动人口(13.27‰),前者无趋势性变化,后者呈上升趋势(χ2=25.02,P<0.01)。出生缺陷患病率前5位分别是先天性心脏病、多指(趾)、唇腭裂、神经管缺陷、外耳畸形。先天性心脏病和“其他”类别的出生缺陷患病率呈上升趋势,而神经管缺陷患病率呈下降趋势。先天性心脏病产前检出比例逐年上升(χ2=14.80, P<0.01)。结论2006~2012年北京通州区出生缺陷患病率呈上升趋势,主要与流动人口出生缺陷率上升,监测出生缺陷类型不断扩展以及先天性心脏病诊断水平提高有关。%Objective To study the dynamic prevalence and epidemiological characteristics of birth defects distribution in the Tongzhou District of Beijing between 2006 and 2012. Methods Data collected from the birth defects surveillance system in the Tongzhou District of Beijing between 2006 and 2012 were used. The prevalence and trends of birth defects were analyzed, also the proportion of birth defects in prenatal diagnosis was calculated. Results Between 2006 and 2012, 1 165 cases of birth defects were identiifed among 92 340 births, with a prevalence of 12.62‰. The prevalence of birth defects showed an increased trend during the seven years (χ2=6.77, P<0.01). The prevalence in the lfowing population (13.27‰) was higher than that in the permanent residents (11.55‰), and the former showed an upward trend during the seven years (χ2

  8. EMI Registry Development Plan

    CERN Document Server

    Memon, S.; Szigeti, G.; Field, L.

    2012-01-01

    This documents describes the overall development plan of the EMI Registry product, the plan focuses on the realisation of the EMI Registry specification as defined in the document. It is understood that during the course of the development phase the specification will likely evolve and the changes will be fed into the specification document.

  9. Paper 6: EUROCAT member registries: organization and activities

    DEFF Research Database (Denmark)

    Greenlees, Ruth; Neville, Amanda; Addor, Marie-Claude

    2011-01-01

    anomalies covered by their region. Associate members transmit aggregate case counts for each EUROCAT anomaly subgroup by year and by type of birth. This article describes the organization and activities of each of the current 29 full member and 6 associate member registries of EUROCAT.......EUROCAT is a network of population-based congenital anomaly registries providing standardized epidemiologic information on congenital anomalies in Europe. There are three types of EUROCAT membership: full, associate, or affiliate. Full member registries send individual records of all congenital...

  10. Analysis of monitoring results of birth defects in Leshan city during 2006-2010%乐山市2006~2010年出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    吴敏

    2012-01-01

    OBJECTIVE To analyze the trend and risk factors of birth defects of 2006 - 2010 Leshan City. METHODS According to the require of the Sichuan birth monitoring program, 23 healthcare organizations were monitored in Leshan City and the results were collected and reported. RESULTS Total incidence rate of birth defects was 9.8 1‰ and the rate of perinatal birth defect in last five years declined significantly. The rate of birth defects of parturient aged from 20 to 35 was significantly higher. There was no significant difference of birth defects between male and female babies. In Leshan City, multi-finger/toe, small ear/no ear, external ear deformities, cleft lip and cleft palate, cleft lip and urethra hypospadias were most common defects; The rate of prenatal diagnosis was 12.26%. The incidence of birth defects associated with inheritance and pre-pregnancy or prenatal monitoring. CONCLUSION Health education, prevention and monitoring of pregnant women should be strengthened in Leshan to reduce the incidence of birth defects.%目的 分析乐山市2006~2010年出生缺陷发生趋势及其高危因素,制定干预措施,降低出生缺陷发生率.方法 按照《四川省出生缺陷监测方案》要求,对乐山市23所医疗保健机构出生缺陷进行监测,由县妇幼保健院收集汇总上报.结果 出生缺陷总发生率9.81%,5年来围产儿出生缺陷发生率历经波峰后稳步下降,差异有统计学意义;孕产妇20岁及35岁年龄组,出生缺陷率明显增高;男性与女性出生缺陷发生率差异无统计学意义;乐山市出生缺陷前6位是多指/趾、小耳/无耳、外耳其他畸形、唇裂并腭裂、唇裂、尿道下裂;产前诊断率12.26%;出生缺陷发生与遗传及孕前产前监测有一定关联.结论 进一步加强育龄妇女及其家庭健康教育促进,增强“三级预防”体系功能,重视婚前孕前检查与产前筛查(诊断)工作,做到早预防、早诊断、早处置,以降低

  11. 四川省双流县2010年~2014年围产儿出生缺陷监测分析%Analysis of birth defects surveillance data of perinatal babies from 2010 to 2014 in Shuangliu county, Sichuan province

    Institute of Scientific and Technical Information of China (English)

    徐珠屏; 王洋

    2016-01-01

    Objective:To understand the condition and causes of birth defects in Shuangliu county,thus provide the scientific basis for improving population quality and reducing birth defects.Methods:The birth defects surveillance data of perinatal babies from 2010 to 2014 in 3 hospitals on a county scale were arranged and analyzed.Results:From 2010 to 2014,The total incidence of birth defects was 9.71‰.The main birth defects types were,in order,congenital heart disease,polydactylism,microtia (including anotia),harelip,syndactylia,all the 5 types birth defects paid 53.23% of all.Among birth defects children,there had a higher ratio in male compared with female,also a higher ratio in town compared with rural area.The data also showed that the maternal ages which were less than 20 or be equal or greater than 35 had a higher ratio of birth defects.The birth defects were the leading cause of perinatal deaths.Conclusion:In order to reduce birth defects and improve population quality,we should carry out the work of birth defects surveillance and comprehensive interventionson a big scale,actively develop the "three-step-prevention" mode of birth defects.%目的 了解四川省双流县围产儿出生缺陷情况及影响因素,为提高人口素质、降低出生缺陷率提供科学依据.方法对2010年~2014年全县3家出生缺陷监测医院分娩的围产儿出生缺陷监测相关资料进行回顾性分析.结果双流县2010年~ 2014年围产儿出生缺陷发生率为9.71‰,是导致围产儿死亡的首要原因;主要出生缺陷依次为先天性心脏病、多指、小耳(包括无耳)、唇裂和并指,占全部缺陷类型的53.23%.结论 应大力开展国产儿出生缺陷监测与综合干预工作,积极开展三级预防工作,以减少出生缺陷的发生,提高人口素质.

  12. Analysis of birth defects supervision in obstetrical hospitals in Beijing Haidian District%北京市海淀区产科医院出生缺陷监测分析

    Institute of Scientific and Technical Information of China (English)

    钟赋真; 张雪峰; 周钰

    2012-01-01

    Objective To understand the incidence of birth defects in hospitals in Haidian District during recent years so as to provide management clue for supervision in the future. Methods From October 1 of 2006 to September 30 of 2010, fetus and newborns between 13 gestational weeks and 7d after delivery were supervised for birth defects in hospitals of Haidian district, and the supervision results were analyzed in terms of rate and cis position. Results There were 3 776 defected cases including 2 861 cases in perinatal period ( the incidence rate of birth defects in perinatal period was 17. 98‰ ) and 906 cases induced to abortion in second trimester. In floating population the incidence rate of birth defects showed a rising trend in perinatal period during these years( x2 =52. 250, P = 0. 000 ). The first five highest rates of birth defects were congenital heart disease, deformity of external ear, multi finger ( toe ), merged finger ( toe ) and hypospadias in order. The trend of neural tube defects rate was stable and the incidence of cleft lip dropped obviously. But the incidence of Trisomy 21 rose gradually, and there was no significant difference (x2 =6. 906, P =0. 075 ). Conclusion The incidence rate of birth defects is 17. 98‰ in hospitals of Haidian district, and the trend of birth defects rate is rising during 2006-2010 year especially in floating population. The primary prevention of folic acid supplement should be strengthened.%目的 了解近年来北京市海淀区医院出生缺陷的发生情况,为今后监测工作的管理重点提供依据.方法 对2006年10月1日至2010年9月30日期间北京市海淀区产科医院孕13周~产后7天的胎儿及新生儿进行出生缺陷监测,并对监测结果进行率及顺位等分析.结果 ①监测到出生缺陷儿3 776例,其中围产期2 861例(围产期出生缺陷儿发生率为17.98‰),中孕引产906例;②2006至2010年,外地户籍围产期出生缺陷发生率呈逐年上升的趋势(χ2

  13. Research Progress of Factors Related to Birth Defect and Interventional Measures%出生缺陷相关因素的研究进展及干预措施

    Institute of Scientific and Technical Information of China (English)

    祝轲

    2011-01-01

    Birth defect prevails worldwide as a heavy burden to the state, society and the family, and affects the quality of population and development of social civilization.It is a basic national policy to control and improve the quality of the population, whereas birth defect is an important factor which affects the quality of the population.In this paper,hereditary factors,environmental factors,drug factors,psychological factors of birth defect are described.The surveillance,tertiary prevention,government intervention,establishment of early warning systems and other research progress of interventional measures of birth defect are discussed,in aiming to improve the quality of the population and protect the population health.%出生缺陷在全世界占有相当高的比例,给国家、社会和家庭带来了沉重负担,影响到人口素质及社会文明的发展.控制人口数量,提高人口素质是我国的一项基本国策,而出生缺陷则是严重影响人口素质的一个重要因素.现从遗传因素、环境因素、药物因素、心理因素等方面阐述出生缺陷的相关因素,并从出生缺陷监测、三级预防、政府政策干预以及建立出生缺陷预警系统等方面探讨出生缺陷干预措施的研究进展,为提高人口素质,保护人群健康提供基础.

  14. Advanced molecular and cytogenetic technologies in birth defect diagnosis and prevention%分子和细胞遗传学新技术在出生缺陷诊断及防治中的应用

    Institute of Scientific and Technical Information of China (English)

    Marilyn M. LI

    2005-01-01

    SUMMARY Fluorescence in situ hybridization (FISH) has become an important diagnostic tool as an adjunct to classical cytogenetics. FISH utilizes DNA probes comprised of specific nucleic acid sequences tagged with fluorescent molecules to identify the number and location of specific DNA sequences in human cells. These probes can be used to determine various numerical and structural chromosomal aberrations, in many cases, gene dosage and/or structure alterations. Chromosomal abnormalities are responsible for a considerable number of birth defects, and more than 50% of spontaneous abortions. These numbers have been significantly higher since the advent of FISH technology that allows the detection of submicroscopic chromosome alterations. The clinic application of FISH technology in postnatal, prenatal, and preimplantation diagnoses has been playing an important role in the diagnosis and prevention of birth defects. As new technologies evolve, more and more new FISH techniques - such as subtelomeric FISH, multicolor FISH (M-FISH), comparative genomic hybridization (CGH), and microarray - are used in clinical diagnoses, the role of FISH technology in both research and clinical aspects of birth defects will surely continue to expand.

  15. 超声检查在出生缺陷预防中的应用%Ultrasonographic examination for prevention of fetal birth defect

    Institute of Scientific and Technical Information of China (English)

    Keong WONG

    2009-01-01

    During pregnancy, a unique and dramatic sequence of events occurs, defining the most remarkable transformation of a single cell into a recognizable human being. Uhrasonographic examination is play a important role for prevention of fetal birth defect. For some years, there have been dramatic advances in ultrasound technology, including improved spatial and contrast resolution, three-dimensionaland four-dimenstional imaging, harmonic imaging, new and improved ultrasound sanning probes, and improved digital review workstations, to name a few. Likewise, our knowledge of normal fetal anatomy and pathology, and the pathophysiology of disease have increased substantially. The internet has made communication among researcheres earier. There have been many collaborative studies and refinements of the guidelines for the performance of the obstetric ultrasound examination. But there are still some differences in the approach to the obstetric ultrasound examination from one group to the others. Some issues such as what constitutes a basic ultrasound examination, what structure should be perform and interpret the examination, how safe is ultrasound, how should it be recorded and documented, how should it be reported,and how accurate rate of diagnosis fetal congenital malformation. In conclusion is that, the appeal of the ultrasound examination is that it is a noninvasive, safe procedure that has a high degree of patient acceptance and can yield a wealth of information. It is always a delight to examine the obstetric patient and reassure her about her pregnancy, when appropriate. However, there are times when an abnormality is strongly suspected but it may be equivoal or may not fit into a specific category. Under these circumstances, the best pathway for the sonologist to is to do a follow-up examination and seek consultation. If time does not allow a follow-up examination, then the sonologist should communicate to the referring physician and the patient that a definiitve

  16. [Role of cancer registries].

    Science.gov (United States)

    Schaffer, P

    1995-05-01

    The first Cancer Registries were created in 1975 in France. Their ulterior development and their scientific production have been furthered by the apparition from 1986 under the aegis of the Health Ministry and of the INSERM, of a National Population Registry Committee. Cancer Registries have seriously contributed to a better knowledge of the cancer problem in our country and to describe the french specificities, in particular the importance of the mouth and pharynx cancers. They insure both a monitoring and an alert role; they also contribute to the medical supervision of the Chernobyl accident effects. French registries play a very active role concerning clinical research. They participate to many European studies of health care evaluation. In other respects, many etiological studies have been realized about professional risks of cancer, risks linked with nutritional habits, and on the etiologic role of the Tamoxifen. Finally, certain registries have created DNA banks. If nowadays their role in health planning remains modest, they very actively contribute in evaluating screening actions of breast, cervix and large bowel cancers. They also attracted the attention of Health Authorities on the cervix cancer screening's incoherencies. They evaluate the pilot project of the breast cancer and the registry of the Côte d'Or country evaluates the efficacity of a randomized colo rectal mass screening study. The main difficulties met by the registries are linked with the development of laws protecting more and more the individual freedoms, making it harder and harder the registration exhaustive character.

  17. 出生缺陷影响因素的meta分析%A meta -analysis of risk factors of birth defects

    Institute of Scientific and Technical Information of China (English)

    贺亚琴; 郑玉华; 王晓成; 梅志强

    2012-01-01

    Objective; To explore risk factors related to perinatal birth defects in order to provide evidence for birth defects prevention. Methods; Twelve papers were analyzed by a meta - analysis method. The cumulative cases and controls were 3 771 and 31 549, respectively. Results; The pooled odds ratio ( OR) values of single - factor - analysis were as follows; family genetic history (5.11), abnormal child - bearing history (2.94) , consanguineous marriage (7. 69) , the number of pregnancy (4. 67) , parity (1.77) , gestational age (0.71) , domestic contamination (2.22) , exposure to harmful substances (4. 37) , catching a cold during pregnancy (2.18) , fever during pregnancy (10.25), drug use (2.98) , pet contacting during pregnancy (3.12) , paternal smoking (2.32) and drinking(1. 90) , dietary intake of fresh vegetables(0. 59) and fruits ( 0.67). The pooled odds ratio ( OR) values of multiple - factor analysis were as follows: family genetic history (2.61), abnormal child - bearing history (2.87), drug use (5. 11), exposure to harmful substances (4.76), paternal smoking (1. 53 ). Conclusion; The risk factors of birth defects are family genetic history and abnormal child - bearing history, consanguineous marriage, the number of pregnancy, parity, and domestic contamination, exposure to harmful substances, catching a cold and fever during pregnancy, drug use, pet contacting during pregnancy, and paternal smoking and drinking. The protective factors are the gestational age and dietary intake of fresh vegetables and fruits.%目的:探讨出生缺陷发生的影响因素,为开展防治工作提供依据.方法:利用meta分析方法研究国内12篇关于出生缺陷发生影响因素的文献.累计病例3 771例,对照31 549例.结果:单因素分析中各因素及其合并比值比(OR)分别为:家族遗传史(5.11)、生育畸形史(2.94)、近亲结婚(7.69)、胎数(4.67)、产次(1.77)、胎龄(0.71)、家庭附近有污染(2.22)、孕期暴露于有害物质(4.37)

  18. 陕西省2006-2010年出生缺陷医院监测结果分析%Analvsis of monitoring results for birth defects in Shaanxi province from 2006 to 2010

    Institute of Scientific and Technical Information of China (English)

    李盘; 周晓娟; 甘露; 杨杨

    2012-01-01

    [Objective] To investigate the incidence and epidemiologic characteristics of birth defects in Shaanxi province, then to provide scientific evidences for the key of future work. [Methods] All perinatal infants aged from 28 weeks of gestation to 7 days after birth in 25 monitoring hospitals in Shaanxi province from 2006 to 2010 were monitored for birth defects. The data were entered by Excel 2003 and analyzed by SPSS 13. 0 software. [Results] The incidence of birth defects in Shaanxi province from 2006 to 2010 was 117. 8 per 10 000. There was an annual ascending tendency in incidence of birth defects(x2 =16. 81 ,P<0. 01). The first five main birth defects were total cleft lip,neural tube defects,congenital heart diseases,polydactyly, congenital hydrocephalus, respectively. The incidence of congenital heart diseases showed a year by year ascending trend(x2 =8. 58,Pbirth defects in rural areas was significantly higher than that in urban area(x2 =70. 72,P<0. 01). Single defects took up 83. 5%. There were 52. 2% cases diagnosed by ultrasound and 45. 9% cases diagnosed by clinical. The Prenatal diagnosis rate was 48. 1%. The perinatal mortality rate was 8. 3%o and showed a year by year descending trend(x2 =6. 91 ,P<0. 01). During the five years,the mortality among defective perinatal infants was significantly higher than that among non-defective perinatal infants, and the incidence of birth defects among dead perinatal infants was also significantly higher than the incidence of other cause of death. [Conclusions] The incidence of birth defect in Shaanxi province from 2006 to 2010 is lower than the nationwide contemporary level. Much attention should be paid to reduce the incidence of birth defects in rural areas, carr,y out the preventive work of neural tube defect and improve the prenatal diagnosis ability of all monitoring hospitals.%[目的]了解陕西省出生缺陷的发生水平及分布特征,为今后工

  19. Changing trend in congenital abdominal wall defects in Eastern region of Ireland.

    LENUS (Irish Health Repository)

    McDonnell, R

    2002-09-01

    In the past six years, there have been reports from abroad of an unexplained rise in the birth prevalence rate of the congenital abdominal wall defect gastroschisis, while rates for the macroscopically similar anomaly omphalocoele have remained stable. The Dublin EUROCAT Registry of congenital anomalies monitors trends in the birth prevalence of birth defects in the eastern region of Ireland. We analysed births of children with omphalocoele and gastroschisis born in the period 1981-2000, with comparisons of a number of demographic and obstetric variables. During the 20 year period the birth prevalence rate for omphalocoele remained stable at 2.5\\/10,000 births, whereas the rate for gastroschisis increased significantly during the 1990s from 1.0\\/10,000 in 1991 to 4.9\\/10,000 in 2000. Most of the increase occurred among mothers under 25 years of age. Omphalocoele was associated with a relatively high proportion of other major congenital anomalies. This study showed that there has been an unexpected rise in the birth prevalence of gastroschisis in the region, similar to that experienced in other countries in the same time period and likely to have common aetiological features.

  20. Analysis of the Relationship Between Pregnancy Checkups and Birth Defects Prevention%孕前优生健康检查与出生缺陷预防的关系分析

    Institute of Scientific and Technical Information of China (English)

    郭勇义

    2015-01-01

    Objective Analysis of the relationship between pre pregnancy checkups and birth defects prevention and its effect on the prevention of birth defects. Methods 355 women who did pre pregnancy health examination in our hospital from January 2010 to December 2013 as the observation group, the other to participate in investigation of 380 cases of women who not for pre pregnancy health examination as control group. Establish files for two groups of pregnant women, recorded follow-up situation, pregnancy outcome, the incidence of birth defects registration, compared incidence of birth defects of two groups. Results In observation group, the incidence of birth defects was 0.3%(1 cases of cleft lip and palate), was significantly lower than control group of 1.9%(3 cases of cleft lip and palate , 2 cases of neural tube defects, 1 cases of congenital heart disease, 1 cases of finger/toe deformity), difference was statistically significance (P0.05). Conclusion Using eugenic health before pregnancy in the application of married female school-age pregnancy before can effectively control their disease, through the analysis of the risk factor intervention, evaluate to prevent birth defects in situation, the maximum reduce the incidence of birth defects in newborns.%目的:探析孕前优生健康检查与出生缺陷预防关系及其在预防出生缺陷方面的效果。方法整群选择2010年1月-2013年12月期间于该院进行孕前优生健康检查355名妇女作为观察组,另以参与调查研究且未行孕前优生健康检查380例妇女作为对照组。为两组孕妇建立档案,对随访情况进行记录,登记妊娠结局、出生缺陷发生率,比较两组出生缺陷发生率。结果观察组出生缺陷发生率为0.3%(1例唇腭裂),显著低于对照组1.9%(3例唇腭裂、2例神经管畸形、1例先天性心脏病、1例指/趾畸形),对比差异有统计学意义(P0.05)。结论孕前优生健康在已婚适龄女性孕产前的应

  1. 昌吉州2005至2010年486例出生缺陷分析%Analysis of birth defects of 486 cases in 2005-2010 in Changji

    Institute of Scientific and Technical Information of China (English)

    陈筱萍; 李冬梅; 马彦华

    2011-01-01

    Objective To investigate the incidence of birth defects and related factors in Changji so as to provide some basis for working out preventive measures for birth defects. Methods A retrospective study was conducted to analyze the data of 486 cases of birth defects collected from each hospital in Changji from 2005 to 2010. Results The incidence of birth defects increased year by year from 2005 to 2010, and it increased in 2010 ( 10. 67‰ ) by 5. 61% compared with that in 2005 ( 5. 06 ‰). The incidence of birth defects when pregnant women were over 35 years and over 40 years was 8. 28% ‰ and 10. 67‰ respectively. The sequence of birth defects was neural tube defects, cleft lip and palate, polydactyly, congenital hydrocephalus, congenital heart disease and talipes equinovarus in order. Conclusion The advanced ages and rural areas are the focus of prevention work. Strengthening propaganda on prenatal and postnatal care, enhancing system management during pregnancy, taking low-dose folic acid tablets before pregnancy and at early pregnancy and improving prenatal diagnostic technique are the effective measures to reduce the incidence of birth defects.%目的 了解昌吉州出生缺陷发生情况及相关因素,为制订预防出生缺陷的措施提供依据.方法 收集昌吉州辖区内各家医院2005至2010年间出生的486例缺陷儿的资料,进行回顾性分析.结果 2005至2010年出生缺陷发生率呈逐年上升趋势,2005年(5.06‰)与2010年(10.67‰)相比上升了5.61‰;年龄大于35、40岁以上妊娠者缺陷发生率分别为8.28‰、10.67‰;出生缺陷的顺位依次为神经管畸形、唇腭裂、多指趾、先天性脑积水、先心病、马蹄内翻.结论 高龄孕妇、农村地区是出生缺陷工作预防的重点,加强优生优育宣传,加强孕期系统管理,在孕前、孕早期服用小剂量叶酸片,提高产前诊断技术,是降低出生缺陷发生率的有效措施.

  2. Retrospective Analysis of Perinatal Birth Defects in a City of Zhe Jiang Province during 2000-2010%浙江省兰溪市2000-2010年围产儿出生缺陷及相关因素分析

    Institute of Scientific and Technical Information of China (English)

    朱兰英

    2011-01-01

    Objective: To analyze the Zhejiang city of birth defects and dynamics in the basic situation, seek to influence the city's main reason for birth defects and prevention strategies. Methods: Maternal and Child Health Hospital of Obstetrics city 2000-2010 Statistical analysis of birth defects. Results: 9458 cases of perinatal birth defects occurred in 216 patients, the total incidence of birth defects 28.86‰; birth defects. child mortality rate 3.62 ‰.The top five birth defects are cleft lip and palate, neural tube development defects. no brain child, congemtal heart disease, umbilical hemia; the incidence of birth defects is proportional to matemal age, 36 years old pregnant women are high risk factors ofbirth defects occur;The incidence of birth defects in rural areas than urban . Conclusions: Prenatal screening of pregnant women of childbearing age, pregnant women of childbearing age in rural areas and knowledge of universal care, prenatal and postnatal care ofwomen during pregnancy bearing age to create a favorable social and cultural environment of birth, in health policy and health insurance system to give moderate tiltreduce the incidence of birth defects.%目的:分析浙江省兰溪市围产儿出生缺陷的基本情况及动态变化,探索影响该市围产儿出生缺陷的主要原因和预防策略.方法:对2000-2010年兰溪市妇幼保健院产科出生缺陷资料进行统计分析.结果:9458例围产儿中发生出生缺陷216例,总出生缺陷发生率28.86‰;出生缺陷儿死亡率3.62‰.出生缺陷前五位的是唇腭裂、神经管发育畸形、无脑儿、先天性心脏病、脐疝;出生缺陷发生率与孕产妇年龄成正比,36岁以上孕妇是发生出生缺陷的高危因素;农村出生缺陷的发生率高于城市.结论:加强育龄孕妇产前筛查、农村育龄妇女孕期护理和相关知识的普及,降低围产儿的出生缺陷发生率.

  3. Birth Defects Data and Statistics

    Science.gov (United States)

    ... or without cleft palate Limb deficiency Trisomy 18 (Edwards syndrome) Hypospadias Asian, Non-Hispanic Spina bifida without anencephaly ... Gastroschisis Omphalocele Black, Non-Hispanic Encephalocele Trisomy 18 (Edwards syndrome) Aortic valve stenosis Cleft lip with or without ...

  4. Reducing Risks of Birth Defects

    Science.gov (United States)

    ... all alcohol while you are pregnant. How can recreational drug use affect my pregnancy? Use of illegal drugs ( ... herpes, syphilis, and infection with human immunodeficiency virus (HIV, the cause of acquired immunodeficiency syndrome [AIDS]). Toxoplasmosis: ...

  5. Screening Tests for Birth Defects

    Science.gov (United States)

    ... condition and are done on cells obtained through amniocentesis , chorionic villus sampling , or, rarely, fetal blood sampling. ... and, in smaller amounts, in the mother’s blood. Amniocentesis: A procedure in which a needle is used ...

  6. Novel features of 3q29 deletion syndrome: Results from the 3q29 registry.

    Science.gov (United States)

    Glassford, Megan R; Rosenfeld, Jill A; Freedman, Alexa A; Zwick, Michael E; Mulle, Jennifer G

    2016-04-01

    3q29 deletion syndrome is caused by a recurrent, typically de novo heterozygous 1.6 Mb deletion, but because incidence of the deletion is rare (1 in 30,000 births) the phenotype is not well described. To characterize the range of phenotypic manifestations associated with 3q29 deletion syndrome, we have developed an online registry (3q29deletion.org) for ascertainment of study subjects and phenotypic data collection via Internet-based survey instruments. We report here on data collected during the first 18 months of registry operation, from 44 patients. This is the largest cohort of 3q29 deletion carriers ever assembled and surveyed in a systematic way. Our data reveal that 28% of registry participants report neuropsychiatric phenotypes, including anxiety disorder, panic attacks, depression, bipolar disorder, and schizophrenia. Other novel findings include a high prevalence (64%) of feeding problems in infancy and reduced weight at birth for 3q29 deletion carriers (average reduction 13.9 oz (394 g), adjusted for gestational age and sex, P = 6.5e-07). We further report on the frequency of heart defects, autism, recurrent ear infections, gastrointestinal phenotypes, and dental phenotypes, among others. We also report on the expected timing of delayed developmental milestones. This is the most comprehensive description of the 3q29 deletion phenotype to date. These results are clinically actionable toward improving patient care for 3q29 deletion carriers, and can guide the expectations of physicians and parents. These data also demonstrate the value of patient-reported outcomes to reveal the full phenotypic spectrum of rare genomic disorders.

  7. Monitoring and analysis of the Population Birth Defects in Tianjin Downtown from 2008 to 2010%天津市区2008~2010年人群出生缺陷监测资料分析

    Institute of Scientific and Technical Information of China (English)

    李宝娟

    2012-01-01

    OBJECTIVE To analyze the population birth defects prevalence and potential affecting factors in Tianjin downtown from 2008 to 2010. METHODS The data of fetus and infants in Tianjin city from 2008 to 2010 were collected and analyzed. RESULTS A total of 1 062 cases with birth defect were collected from 65 990 births, with an overall prevalence rate of 160.93/104 births. The rates in male and female births were 172.34/104 births and 146.65/104 births, and there was significant difference between the two groups (r = 6.902, P< 0.01). Compared with 20-29 years old, the rate was 189.61/104 births in an age ≥30 years group, especially, the rate was 482.76/104 births in an age ≥40 years group (χ2 = 18.849, P < 0.001). There was significant difference in premature delivery and low birth weight babies (χ2 = 404.491, P< 0.001; χ2 = 381.164, P < 0.001). The rate was 3 505.98 per 10 000 births in fetal death and stillbirth, early neonatal death and death with in 7-42 days. The rate was 25.91 times of live-births (χ2 = 3 663.76, P< 0.01). Birth defect risk factors included male births, elderly puerperal, premature delivery babies and babies with low birth weight. CONCLUSION Annual prevalence rate of birth defect in Tianjin presented an increasing trend. The improvement ability in diagnosis and monitoring should be partly accounted for it. Birth defects were more likely to occur in elderly puerpera's babies, premature and low birth weight babies. The babies were mortality in high and poor prognosis.%目的 了解2008~2010年天津市区人群出生缺陷的发生情况及其影响因素.方法 对2008~2010年居住在天津市市内6区的产妇所分娩的胎婴儿资料进行分析.结果 共收集围产儿65 990例,出生缺陷儿1 062例,发生率为160.93/万.男、女性胎婴儿出生缺陷发生率分别为172.34/万和146.65/万,差异有统计学意义(x2=6.902,P<0.01);与20~29岁相比,产妇年龄在30岁以上,尤其是40岁以上时,胎婴

  8. Data Element Registry Services

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data Element Registry Services (DERS) is a resource for information about value lists (aka code sets / pick lists), data dictionaries, data elements, and EPA data...

  9. Research on the influence factors of birth defect in Zhongshan City%中山市出生缺陷发生的相关影响因素调查分析

    Institute of Scientific and Technical Information of China (English)

    熊付兴; 王丹; 史妙丽

    2016-01-01

    目的:调查分析中山市出生缺陷的相关影响因素,为出生缺陷一级干预提供决策支持。方法选择2014年1月至2016年1月中山市105例出生缺陷儿作为缺陷组,同期选择105例无出生缺陷的新生儿作为对照组。对两组父母的“国家免费孕前优生健康检查项目”档案中疾病史、用药史、孕育史、家族史、饮食营养、生活习惯、环境毒害物接触、社会心理因素以及孕前的各种医学检验结果进行分析。结果两组父母文化程度、在孕产史、用药史、饮食营养、生活习惯、生活环境、疾病史、家族遗传病史等因素比较,差异有统计学意义(P <0.05)。家庭经济收入低、孕期营养状况差、早孕期自然流产、死胎死产、曾用避孕药、被动吸烟、接解放射线是出生缺陷的危险因素。结论新生儿出生缺陷的危险因素较多,临床医生需加强宣传,指导女性进行婚前、孕前检查,养成良好的生活习惯,从而减少新生儿出生缺陷的发生。%Objective To investigate and analyze the related influence factors of birth defect in Zhongshan City,Providing decision support for the first -level intervention.Methods 105 children with birth defect in Zhongshan City from January of 2014 to January of 2016 were selected as defect group,and 105 children without birth defect were selected as control group.The disease history,medication history,birth history,family history,diet,living habits,environmental poisonexposure,social psy-chological factors and pre -pregnancy medical testing results from "national free pre pregnancy health check"archives were ana-lyzed.Results The differences in the degree of education,history of gestation,history of pharmacy,diet nutrition,living hab-it,diseases history,history of family genetic disease and some other factors of parents between two goups were statistically signifi-cant (P <0.05).The low family income,bad nutriture at

  10. 产前超声诊断胎儿出生缺陷的临床分析%The Clinical Study on the Diagnosis of Fetal Birth Defect by Prenatal Ultrasound Examination

    Institute of Scientific and Technical Information of China (English)

    马澜竹

    2015-01-01

    目的:探究产前超声诊断对胎儿出生缺陷的临床分析。方法选取2012年4月~2013年12月在我院就诊的627例孕妇进行产前的超声诊断,观察超声检查的图像。结果产前超声诊断的符合率为95.12%,漏诊率为4.9%,符合率较高,准确率高,有统计学意义(P<0.05)。结论产前的超声诊断能够准确检查出胎儿的出生缺陷问题,提高优生优育,为胎儿出生缺陷干预重要有效的方法。%Objective Clinical study on the diagnosis of fetal birth defect by prenatal ultrasound examination is to be investigated. Methods Chose 627 pregnant women who were received and treated in hospital from April 2012 to December 2013 and get them tested by prenatal ultrasound examination. And then make an observation on ultrasound image. Results The accuracy of prenatal ultrasound examination was up to 95.12%,and misdiagnosis probability was 4.9%; the prenatal diagnosis was of high accuracy and its outcome had statistic value(P<0.05). Conclusion Prenatal ultrasound examination is of high accuracy in diagnosis of fetal birth defect which is beneficial to improve sound birth and superior nurture; it is a quite effective way to prevent from fetal birth defect.

  11. Analysis on the status of birth defects of Derinatal infants between 2001 and 2010 inZhoushan IslandsZheiiana Province%舟山群岛2001年~2010年围产儿出生缺陷资料分析

    Institute of Scientific and Technical Information of China (English)

    徐君球

    2011-01-01

    目的 了解舟山群岛10年间围产儿出生缺陷发生情况及变化趋势,探寻和分析出生缺陷发生因素.方法 采用纵向比较方法对舟山群岛出生缺陷资料进行分析.结果 出生缺陷发生率14.43‰,本地和流动经检验无差异,出生缺陷前10位顺位以先天性心脏病、唇腭裂、副耳等为主.结论 建立健全出生缺陷三级预防机制,多措施降低出生缺陷发生率.%Objective: To understand the status and trend of birth defects and explore and analyze the occurred factors of birth defects among ten years in Zhoushan Islands of Zhejiang Province. Methods: Longitudinal comparison method was used to analyze the data of birth defects in Zhoushan Islands. Results: The incidence of birth defects was 14. 43%e, there was no significant difference in the incidence of birth defects between local and mobile; the first ten diseases of birth defects were congenital heart disease, cleft lip with palate and vice ear and so on. Conclusion: The relevant departments should establish the mechanism of tertiary prevention of birth defects and make various measures to reduce the incidence of birth defects.

  12. 开封市出生缺陷影响因素病例对照研究%Case-control study on influencing factors of perinatal birth defects in Kaifeng city

    Institute of Scientific and Technical Information of China (English)

    王珊; 潘新娟; 余增丽

    2013-01-01

    [目的] 探讨开封市围产儿出生缺陷的影响因素,为出生缺陷干预提供科学依据. [方法] 2006年10月-2011年10月开封市468例出生缺陷儿的产妇为病例组,同一医院随机抽取646例于同时期分娩正常新生儿的产妇为对照组,进行回顾性调查,用单因素与多因素Logistic回归分析筛选出生缺陷的主要影响因素. [结果] 研究因素中,有12个影响因素的发生率病例组与对照组的差异有统计学意义(P<0.05),其中危险因素是7个,保护因素5个;对单因素分析中有统计学意义的变量进行多因素Logistic回归分析,其中,婚前体检(OR=0.65),经常食用鱼虾肉蛋类、牛奶豆类等优质蛋白类食物(OR=0.59)为出生缺陷的保护性因素;而母亲吸烟饮酒(OR=2.02)、母亲致畸因素接触史(OR=1.63)、孕育期用药(OR=4.23)、孕育期接触有害物质(OR=13.26)、居住地有污染源(OR=10.23)等5个因素为出生缺陷的危险因素. [结论] 母亲吸烟饮酒、母亲致畸因素接触史、孕育期用药、孕育期接触有害物质、居住地有污染源等因素为出生缺陷的主要危险因素.减少和控制孕期主要危险因素是预防出生缺陷的重要环节.%[Objective] To explore the influencing factors of perinatal birth defect,and provide scientific basis for intervention. [Methods] 468 perinatal birth defects infants were selected as case group,and 646 normal infants as control group. According to the birth date and sex matching principle,Logistic regression was used to analysis muti-factor. [Re-sults] Regular intake of fish,shrimp,meat,eggs,milk and beans during pregnancy(OR=0. 59) participating in pre-marital medical examination(OR = 0. 65) were the protective factors of birth defects. The habit of smoking and drinking(OR = 2. 02) , the history of mother exposure to teratogenic factors(OR= 1. 63) ,medication during pregnancy(OR = 4. 23) .exposure to harmful substances during pregnancy(OR = 13. 26

  13. Survey of knowledge, attitudes and practice of preventing birth defects in married reproduction women%已婚育龄妇女预防出生缺陷知识、态度和行为的调查

    Institute of Scientific and Technical Information of China (English)

    洪己东; 翁彦云; 徐沛金; 戴黎玫; 武英

    2015-01-01

    Objective To evaluate the effect of health education on preventing birth defects in community in terms of knowledge, attitude and practice (KAP) for married women in reproductive age. Method A self-designed general information form and a questionnaire on KAP of married women′s preventing birth defects were used to investigate the KAP among 300 married nulliparous women. Result The average rate of cognitive knowledge of birth defects was 60.8%, the average rate of cognitive behaviors was 59.2%, and the average rate of cognitive attitude was 67.4%. Conclusion In order to reduce the rate of birth defects and improve the quality of births, we should implement three-level prevention education system, enrich the health education methods to enhance the knowledge, attitude and behavior of married women.%目的:了解已婚育龄妇女预防出生缺陷知识、态度和行为情况,为制订相关的护理对策提供依据。方法采用自行设计的一般资料调查表和预防出生缺陷知识、态度和行为调查表对300名已婚育龄妇女进行调查。结果已婚育龄妇女预防出生缺陷知识平均认知率为60.8%,行为平均认知率为59.2%,态度平均认知率为67.4%。结论实施三级预防,采取多种形式的健康教育方法以提高已婚育龄妇女预防出生缺陷知识、态度和行为水平,从而降低出生缺陷率,提高出生人口的素质。

  14. Analysis on birth defect surveillance in south Xicheng District, Beijing%北京市西城南区围产儿出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    赵丽霞; 王淼

    2011-01-01

    Objective To analyze the birth defect of south Xicheng District, Beijing from 2008 to 2010, and observe the feature of the birth defect incidence. Methods Statistics and analysis of birth defect infants from 6 hospitals of south Xicheng district in Beijing were performed, 293 perinatal infants and 88 infants (induction of labour in second trimester) were found. Results The incidence of birth defect of south Xicheng district in Beijing from 2008 to 2010 was 14.51‰. There were 20190 perinatal infants, and 132 of them were dead. The mortality was 6.54‰. 25 of them were infants with birth defects. The percentage was 18. 98%. The incidence of birth defect in these 293 cases, from high to low, in turn were: congenital heart disease (3.37‰) , polysyndactyly (2.82‰) , deformity of external ear (1.04‰), syndactyly (0. 74‰) , anorectal atresia (0.45‰) , cleft lip(0.35‰) , microtia(0.35‰). Conclusion As the incidence rate of congenital heart disease and other defects were quite high, intensify health care in perinatal period should be promoted, and the level of antenatal diagnosis should be enhanced.%目的 分析北京市西城南区2008-2010年出生缺陷监测结果,了解本地区出生缺陷发生情况.方法 对2008-2010年北京市西城南区6家助产机构产科孕满28周至出生后7d的出生缺陷儿293例,以及因出生缺陷进行中期引产的胎儿88例进行出生缺陷结果分析.结果 2008-2010年北京市西城南区围产儿出生缺陷发生率为14.51‰;20190名围产儿中共132例围产儿死亡,死亡率为6.54‰,其中出生缺陷25例,占围产儿死亡的18.98%;293例出生缺陷发生率由高到低依次为先天性心脏病(3.37‰)、多指(趾)(2.82‰)、外耳其他畸形(1.04‰)、并指(0.74‰)、直肠肛门闭锁或狭窄(0.45‰)、唇裂(0.35‰)、小耳(0.35‰).结论 进一步提高产前诊断水平,增强围孕保健措施.

  15. Analysis of the trend in prevalence of birth defects in Guangxi from 2001 to 2010%2001-2010年广西壮族自治区围生儿出生缺陷分析

    Institute of Scientific and Technical Information of China (English)

    曾萼

    2012-01-01

    Objective To investigate the prevalence of birth defects and its variation from 2001 to 2010 in Guangxi.Methods According to national birth defect monitoring program,all perinatal infants in the birth defects monitoring hospitals in Guangxi from 2001 to 2010 were investigated and statistically analyzed for prevalenee of birth defects( per ten thousand),incidence rates of major birth defects,category and correlating factors.Results In recent 10 years,540 449 perinatal infants were monitored.And 10 897 cases of birth defects were identified with a prevalence rate of 201.63 per ten thousand.The main deformities were fetal edema syndrome,polydactyly,congenital heart disease,cleft lip and external ear malformation.The prevalence of birth defects among boys in the period of 2001-2010was significantly higher than that among girls and that in rural areas was significantly higher than that in the urban areas,and the differences were significant ( x2 =43.71,4.04 respectively,both P < 0.05 ).The prevalence rate of birth defects in 35 ~ age group was the highest and it was significantly higher than that in the < 20 age group,~ 25 age group,25 age group and 30 ~ age group ( x2 =9.17,41.33,58.77,29.10 respectively,all P < 0.05 ).There was an ascending tendencyin prevalence rate of birth defects in the period of 2001 and 2005,and there was a descending tendency in the period of 2005 and 2010.Conclusion Strengthening tertiary prevention measures,and improving skills of the medical wokers for prenatal diagnosis were effective measures to reduce the prevalence of birth defects.%目的 分析广西壮族自治区2001-2010年围生儿出生缺陷特征及变化趋势.方法 按照国家出生缺陷监测方案,对2001-2010年广西壮族自治区围生儿出生缺陷监测医院的围生儿进行出生缺陷监测,统计分析出生缺陷的发生率、类别和相关因素.结果 10年共监测围生儿540 449例,其中出生缺陷儿10 897例,发生率为201.63/万.出

  16. 三峡库区1386例出生缺陷鉴定结果分析%Analysis on the results of birth defects identification in 1386 cases in Three Gorges Reservoir Area

    Institute of Scientific and Technical Information of China (English)

    马明福; 李川海; 杨皓; 付新云; 李家菊; 崔蓉; 李练兵

    2012-01-01

    Objective: To provide a scientific basis for pregestational eugenics, genetic counseling, prevention, and reducing the recurrent risk of birth defects by understanding and grasping the current situations of birth defects and genetics, types, pathogenesis, and areal distribution in Three Gorges Reservoir area. Methods: The research objects received physical examination on the spot, assistant examination was performed; birth defects of the cases were identified and diagnosed definitely. Results; A total of 5 462 cases were identified, 75 kinds of birth defects were diagnosed definitely in 1 386 cases, the incidence of birth defects was 25. 38%. Among the cases with birth defects, 378 cases were found with monogenic inheritable diseases (38 kinds) , accounting for 27. 27% ; 146 cases were found with autosomal dominant inheritable diseases (18 kinds) , accounting for 10." 53% ; 130 cases were found with autosomal recessive dominant inheritable diseases (14 kinds) , accounting for 9. 38% ; 44 cases were found with X-linked dominant inheritable diseases (3 kinds) , accounting for 3. 17% ; 58 cases were found with X — linked recessive inheritable diseases (3 kinds) , accounting for 4. 18%. A total of 20 kinds of poly-genic inheritable diseases were diagnosed in 856 cases, accounting for 61. 76% of the total incidence. A total of 87 cases were found with chromosomal inheritance diseases (4 kinds) , accounting for 6. 28% of the total incidence. A total of 65 cases with other birth defects were found, accounting for 4. 69% of the total incidence. Conclusion: Many types of diseases were involved into birth defects in Three Gorges Reservoir Area; in order to prevent birth defects and reduce the incidences of birth defects, pregestational eugenics and health education, genetic counseling should be carried out actively, pregestational examination, prenatal screening and diagnosis should be strengthened.%目的:通过了解和掌握重庆所属三峡库区区县的出生缺陷

  17. 0~1岁婴儿出生缺陷的流行病学调查%Research on the epidemiology of birth defect for infants aged 0~1

    Institute of Scientific and Technical Information of China (English)

    肖德卫; 骆艳; 贺赞群; 刘树青

    2016-01-01

    目的::研究可对0~1岁婴儿出生缺陷产生影响的流行病学调查.方法:随机选取5394例我市2014.4-2015.4出生的婴儿,所有婴儿在进行研究调查时均为0~1岁,对婴儿一般资料进行收集,将有出生缺陷的婴儿设为 A组,将无出生缺陷的婴儿设为 B组,采用 Logistic回归分析探讨对婴儿出生缺陷的影响因素.结果:所有本文选取的5394例婴儿中,在出生后立即检查出出生缺陷的婴儿有117例,在随后的调查以及随访工作中发现出生缺陷的9例,共126例(A组),占比为2.34%,另B组无出生缺陷的婴儿为5268例(97.66%).A、B两组婴儿在性别、体重、孕母孕期服用叶酸、维生素、微量元素情况、家庭成员吸烟酗酒情况方面存在较大差异(P<0.05).将上诉有差异资料带入 Logistic回归方程中计算,结果发现,出生性别、体重、孕母孕期服用叶酸、维生素、微量元素情况、家庭成员吸烟酗酒情况均是婴儿出生缺陷的影响因素.结论孕妇孕期服用适量维生素、叶酸以及微量元素,对体重过低的新生儿进行焊钳检查,对孕妇进行孕期营养摄入的相关健康宣教,以上这些措施均可有效改善新生儿缺陷.%Objective:To conduct the epidemiology research of birth defect for infants aged 0~1.Method:5394 infants (aged 0~1)delivered from A-pril 2014 to April 2015 in our city were selected.The general data was collected.The infants with birth defect were selected as Group A;the infants without birth defect were selected as Group B.Through the Logistic regression equation,the influence factors of birth defects were analyzed.Result:For 5394 infants,there were 117 cases with birth defects;during the follow-up visits,there were 9 additional cases with birth defects.There were 126 cases with birth defects in total (Group A)(2.34%);Group B had 5268 cases without birth defects (97.66%).The infant’s gender and weight

  18. Analysis of perinatal birth defects monitoring results in Gansu province from 2001 to 2008%甘肃省2001年~2008年围产儿出生缺陷监测结果分析

    Institute of Scientific and Technical Information of China (English)

    丁秀琴; 郭瑛泉; 张玲; 廖丽萍

    2011-01-01

    Objective: To discuss the trend of birth defects incidence, species and changes in Gansu province, in order to provide evidence for preventive measure.Methods: According to Chinese Birth Defects Monitoring Program and Maternal and child health surveillance program in Gansu Province, to monitor perinatal birth in 43 hospitals in Gansu province from 2001 to 2008.Results:( 1 ) In 8 years, the birth defects average incidence is 11.043 per thousand, its trend began go up in 2004, but there is no statistical difference between every years.(2) And the birth defects average incidence no statistical difference between boys and girls ( P >0.05 ); The pregnant motheres age distribution characterized with "two side high and middle low", the lowest incidence (5.9 -9.7 per thousand ) is at 25 - 29 years age group, higher in country than in city ( P < 0.05 ).( 3 ) In 8 years, most common birth defects were neural tube defects, congenital hydrocephalus, cleftlip, talipes equinovarus, limb shorten, polydactyly and congenital heart disease.Neural tube defects and congenital hydrocephalus were always in first there birth defects in Gansu province.Conclusion: Neural tube defects, congenital hydrocephalus, cleftlip are high incidence in all birth defects, which are result of genetic or environmental factors, or interaction of both.Prevention is preior to therapy.Aiming at high detection rate of birth defects, to establish effective administrative intervention and medical care meature.%目的 探讨甘肃省出生缺陷的发生率、种类及变化趋势,为预防措施的制定提供依据.方法 按<中国出生缺陷监测方案>及<甘肃省妇幼卫生监测方案>,对甘肃省2001年~2008年间在43家监测医院住院分娩的围产儿进行监测.结果 (1)8年间的出生缺陷发生率平均为110.43/万,2004年起有明显上升趋势,各年份间出生缺陷发生率无显著的统计学差异.(2)胎儿性别间出生缺陷发生率

  19. How Suitable Are Registry Data for Recurrence Risk Calculations?

    DEFF Research Database (Denmark)

    Ellesøe, Sabrina Gade; Jensen, Anders Boeck; Ängquist, Lars Henrik

    2016-01-01

    identifier in the Danish registries, thus enabling connection of information from several registries. Utilizing the CPR number, we identified Danish patients with familial CHD and reviewed each patient's file. We compared diagnoses from the registries with those manually assigned, which enabled calculation......BACKGROUND: Congenital heart disease (CHD) occurs in approximately 1% of all live births, and 3% to 8% of these have until now been considered familial cases, defined as the occurrence of two or more affected individuals in a family. The validity of CHD diagnoses in Danish administrative registry...... data has only been studied previously in highly selected patient populations. These studies identified high positive predictive values (PPVs) and recurrence risk ratios (RRRs-ratio between probabilities of CHD given family history of CHD and no family history). However, the RRR can be distorted...

  20. Birth Control

    Science.gov (United States)

    Birth control, also known as contraception, is designed to prevent pregnancy. Birth control methods may work in a number of different ... eggs that could be fertilized. Types include birth control pills, patches, shots, vaginal rings, and emergency contraceptive ...

  1. Risk factors for birth defects:A community-based child survey%社区儿童的出生缺陷影响因素探讨

    Institute of Scientific and Technical Information of China (English)

    李敏; 赵丽萍; 商颖; 蔡建华; 周维谨; 车焱

    2011-01-01

    目的:了解以社区为基础的出生缺陷发生水平和有关影响因素,为出生缺陷的预防和孕期保健提供依据.方法:采用多阶段分层整群抽样方法,从我国东、中、西部地区9个中等发达省份中各抽取1个国家人口计生委信息采集抽样县,每个县抽取2个乡镇,再从中各抽取2~4个居委(村),调查其中所有已婚育龄妇女≤9岁子女的出生缺陷发生及相关信息,通过单因素分析和多元logistic回归分析,探讨出生缺陷的影响因素.结果:调查对象共3958例,出生缺陷发生率为1.80%.单因素卡方检验发现母亲产龄、文化程度、流产史、孕期微量营养素补充、产检机构与出生缺陷发生有关(P <0.05).多元logistic回归分析显示,产龄16~20岁(OR=2.53,95 % CI:1.25~5.10)、有人工流产史(OR=3.32,95% CI:1.69~6.51)、吸烟(OR=3.34,95 % CI:1.04~10.75)、孕期未补充微量元素(OR=1.84,95%CI:1.07~3.16)、在乡镇及以下机构产前检查(OR=1.70,95% CI:1.06~2.74)的母亲生育出生缺陷儿的危险较高.结论:出生缺陷预防干预应重点关注既往有人工流产史、低龄、吸烟孕妇对象,重视基层产前检查机构服务能力建设,提供优质孕期监测与营养保健咨询服务.%Objective; To explore the prevalence and risk factors for birth defects ( BD) among children in 9 provinces of China. Methods; By using stratified, random cluster sampling methods, 17 townships and 36 rural villages and urban neighbourhood were sampled from 9 provinces of China. All married women aged between 20 - 49 years old were investigated and a questionnaire survey on birth defects of their children under 9 year - old was conducted. Chi - square test and multivariate logistic regression analysis were used to evaluate the association between BD and maternal risk factors. Results: There were 3 958 respondents, and the prevalence of BD was 1.80%. Results of chi - square tests indicated that maternal age

  2. 2003-2010年南宁市婚前保健与出生缺陷发生状况分析%Premarital Health Care and Birth Defects Situation in Nanning,2003-2010

    Institute of Scientific and Technical Information of China (English)

    李颖; 龚祖康; 覃颛; 李芳

    2011-01-01

    Objective To analyze the pre - marital medical examination ( PME) and birth defects situation in Nanning, improve the quality of the newbom population, and provide the theoretical evidence for formulating birth defect preventive measure scientifically. Methods The PME and birth defects situation in Nanning from 2003 to 2010 was analyzed. Results The PME rate in 2002 was 70. 66%. From 2003 to 2010, totally 1 087 060 people registrated marriage, 167 931 people had accepted PME, the average rate of PME was 15.45% ;during 2004 - 2008 the PME rate maintains between 2% to 3. 37%. Free PME was conducted since June,2009, with the PME rate of 14. 73% , and by 2010, the PME rate reached 65. 70% . The detected prevalence rate was 15. 70% . There were totaUy 10 437 birth defects during 2003 - 2010, the incidence rate was 16. 24 ‰, in which fetal edema syndrome ( thalassemia children) ranked frist Birth defects rate in 2002 was 14.73‰, and in 2010 was 18. 72‰. Conclusion The PME rate in Nanning during 2003 - 2008 was low, which increased after implementation of free PME. PME has the positive sense to reduce the birth defects rate.%目的 分析南宁市婚前医学检查(婚检)与出生缺陷发生状况,提高出生人口素质,为科学制定出生缺陷预防措施提供理论依据.方法 对2003-2010年南宁市婚检与出生缺陷发生状况进行分析.结果 2002年婚检率为70.66%.2003-2010年南宁市结婚登记人数1087 060人,婚检人数167 931人,平均婚检率15.45%;2004-2008年婚检率持续在2%~3.37%,2009-06起实施免费婚检,婚检率14.73%,2010年婚检率达65.70%.检出患病率15.70%.2003-2010年出生缺陷儿共10 437人,发生率16.24 ‰,胎儿水肿综合症(地贫儿)排列出生缺陷第1位,2002年出生缺陷为14.73‰,2010年出生缺陷率18.72‰.结论 2003-2008年南宁市婚检率较低,免费婚检后高婚检率上升,婚检对降低出生缺陷有积极意义.

  3. The Danish Stroke Registry

    DEFF Research Database (Denmark)

    Johnsen, Søren Paaske; Ingeman, Annette; Hundborg, Heidi Holmager

    2016-01-01

    AIM OF DATABASE: The aim of the Danish Stroke Registry is to monitor and improve the quality of care among all patients with acute stroke and transient ischemic attack (TIA) treated at Danish hospitals. STUDY POPULATION: All patients with acute stroke (from 2003) or TIA (from 2013) treated...... at Danish hospitals. Reporting is mandatory by law for all hospital departments treating these patients. The registry included >130,000 events by the end of 2014, including 10,822 strokes and 4,227 TIAs registered in 2014. MAIN VARIABLES: The registry holds prospectively collected data on key processes...... of care, mainly covering the early phase after stroke, including data on time of delivery of the processes and the eligibility of the individual patients for each process. The data are used for assessing 18 process indicators reflecting recommendations in the national clinical guidelines for patients...

  4. 宜昌市城区2008~2010年医院出生缺陷补漏调查%Investigation on the mend Leakage on the birth defects in Yichang between 2008 and 2010

    Institute of Scientific and Technical Information of China (English)

    周小葵

    2012-01-01

    OBJECTIVE To understand the omissions and quality of report card on the birth defects in Yichang city between 2008 and 2010. METHODS We investigated the omissions and quality of report card on the birth defects in midwifery agency of Yichang city on the basis of the National monitoring project of health of mothers and children. RESULTS The leakage rate was 7.49%, and the mistaking rate was 1.26% in the tables and cards. The two rates decreased year by year. CONCLUSION The fundamental guarantee of improving the quality of monitoring in the birth defects was the strengthening of management and supervision , and the raising responsibility of medical staff.%目的 了解宜昌市城区2008~2010年医院出生缺陷漏报及报告卡质量情况.方法 根据《全国妇幼卫生监测方案》对出生缺陷监测质量的要求,对城区各助产机构出生缺陷漏报及报告卡质量情况进行调查.结果 2008~2010年宜昌市城区医院出生缺陷漏报率平均达7.49%;表、卡填写差错率平均达1.26%.漏报率和差错率都有逐年下降趋势.结论 加强管理,坚持督导,提高医务人员责任心,是提高出生缺陷监测质量的根本保证.

  5. Danish Hip Arthroscopy Registry

    DEFF Research Database (Denmark)

    Mygind-Klavsen, Bjarne; Grønbech Nielsen, Torsten; Maagaard, Niels

    2016-01-01

    and Pincer resection in 93.5% of the cases. Labral refixation or repair was done in 70.3% of the cases. The most common type of acetabular chondral damage was grade II lesions (36.6%). Grade III and IV changes were seen in 36.1% of the cases. The preoperative iHOT12 was 45 (mean) based on all 12 items. EQ-5D....... The problems with development and maintaining a large clinical registry are described and further studies are needed to validate data completeness. We consider the development of a national clinical registry for hip arthroscopy as a successful way of developing and maintaining a valuable clinical...

  6. The Danish Heart Registry

    DEFF Research Database (Denmark)

    Özcan, Cengiz; Juel, Knud; Flensted Lassen, Jens;

    2016-01-01

    AIM: The Danish Heart Registry (DHR) seeks to monitor nationwide activity and quality of invasive diagnostic and treatment strategies in patients with ischemic heart disease as well as valvular heart disease and to provide data for research. STUDY POPULATION: All adult (≥15 years) patients...... undergoing coronary angiography (CAG), percutaneous coronary intervention (PCI), coronary artery bypass grafting, and heart valve surgery performed across all Danish hospitals were included. MAIN VARIABLES: The DHR contains a subset of the data stored in the Eastern and Western Denmark Heart Registries (EDHR...

  7. Psoriatic Arthritis Registries.

    Science.gov (United States)

    Sarzi-Puttini, Piercarlo; Varisco, Valentina; Ditto, Maria Chiara; Benucci, Maurizio; Atzeni, Fabiola

    2015-11-01

    The introduction of new biological drugs for the treatment of rheumatoid arthritis and spondyloarthritis has led to the creation of a number of registries in Europe and the United States. Most of them are sponsored by national rheumatology societies, and provide information that is useful in clinical practice concerning the clinical characteristics, efficacy, and safety of all licensed biological drugs. Their findings also help to improve our understanding of the quality of life and working ability of patients receiving biological drugs, and suggest methods for allocating resources. However, there are only a few registries for psoriatic arthritis, and efforts should be made to increase their number to obtain further reliable and useful data.

  8. The Qingdao Twin Registry

    DEFF Research Database (Denmark)

    Duan, Haiping; Ning, Feng; Zhang, Dongfeng;

    2013-01-01

    In 1998, the Qingdao Twin Registry was initiated as the main part of the Chinese National Twin Registry. By 2005, a total of 10,655 twin pairs had been recruited. Since then new twin cohorts have been sampled, with one longitudinal cohort of adolescent twins selected to explore determinants...... of metabolic disorders and health behaviors during puberty and young adulthood. Adult twins have been sampled for studying heritability of multiple phenotypes associated with metabolic disorders. In addition, an elderly twin cohort has been recruited with a focus on genetic studies of aging-related phenotypes...

  9. Study of incidence and influencing factors of birth defect among perinatal infants in Tianhe District, Guangzhou%广州市天河区出生缺陷相关因素的病例对照研究

    Institute of Scientific and Technical Information of China (English)

    李绚; 赵晓骁; 陈温容

    2014-01-01

    目的:了解广州市天河区以医院为基础的围产儿出生缺陷发生水平及相关危险因素,为出生缺陷的干预提供科学依据。方法:以2011年10月1日至2012年9月30日在广州市天河区16家医院分娩或引产的孕28周至产后7 d的围产期出生缺陷患儿作为病例组,以1∶1配对方式选择同期在同一家医院分娩的正常新生儿作为对照组,对家长进行问卷调查,采用多因素Logistic回归分析筛选出生缺陷的危险因素。结果:出生缺陷发生率18.47‰,前3位出生缺陷依次为先天性心脏病、多指(趾)、唇裂。多因素Logistic回归分析显示,孕期放射线接触史(OR=2.205,95%CI:1.178~3.481,P=0.011)、孕期吸烟(OR=1.899,95%CI:1.270~2.839,P=0.002)、母亲先天性疾病史( OR=2.124,95%CI:1.243~3.629,P=0.006)、孕出生缺陷儿史(OR=3.893,95%CI:2.319~6.535,P<0.001)是出生缺陷的危险因素;孕期经常摄入优质蛋白(OR=0.874,95%CI:0.768~0.994,P=0.040)是出生缺陷的保护因素。结论:减少和控制孕期主要危险因素是预防出生缺陷的重要环节。%Objective:To explore the incidence and risk factors for birth defect among hospital-based perinatal infants and to provide scientific basis for intervention of birth defects .Methods:Perinatal infants in 16 hospitals in Tianhe District from October 2011 to September 2012 were selected as case group and normal newborn selected from same period and same hospital as control group , birth defect risk factors were analysed by multivariate Logistic regression .Results:Incidence of birth defects was 18.47‰, the former three birth defects were congenital heart disease, multi-finger(toe), cleft lip.Logistic regression analysis showed that the history of radiation exposure during pregnancy (OR=2.205,95%CI:1.178~3.481,P=0.011), smoking during pregnancy (OR=1.899, 95%CI:1.270 ~2

  10. 武汉地区1137例独生子女病残儿出生缺陷病种分析%Analize the disease of birth defect in 1137 cases of the one-child in wuhan

    Institute of Scientific and Technical Information of China (English)

    占丽娜

    2011-01-01

    目的 通过近l0年来武汉市独生子女病残儿鉴定出生缺陷情况分析,探讨减少出生缺陷疾病再发生的防治措施.方法 武汉市辖区中申请病残儿鉴定的独生子女,资料进行审查和分析,经现场体检及相关的辅助检查,专家对疾病作出鉴定结论并进行归类.结果 诊断为出生缺陷441例,占38.78%.其中遗传性疾病34种346例(78.45%),非遗传性疾病27种95例(21.06%),以神经系统为主.结论 出生缺陷涉及病种多,病因复杂,应根据不同原因引起的出生缺陷,寻找对应的防治措施.%Objective: To discuss the preventive treatment of reducing the birth defect by analizing the information of the disablement child of the one-child in the recent ten years. Methods: Analize and reviewed the information of the disablement child of the one-child , and classified them by the medical examination and the relevant supplementary examination. Results: There were 441 cases of birth defects in the 1137 cases of the one-child, which were accounts for 38. 78%. In those the hereditary diseases were 346 caess (78.45% ), which the diseases species were 34. And inhereditary diseases were 27, which mained in the nervous system. Conclusion: The diseases species is many as the causes is complicated in birth defects. Looking for the preventive and treat measures should according to different causes of birth defects,

  11. Analysis of the Monitoring Results of Perinatal Birth Defects and Related Risk Factors%围产儿出生缺陷及相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    余灵辉; 李海燕; 曹登成

    2016-01-01

    [Objective]To investigate the occurrence of birth defects in perinatal infants and to analyze the related risk factors .[Methods]From March 2011 to March 2015 ,110 cases of perinatal birth defect that occurred in our hos‐pital were selected as the observation group .According to 1:3 matching principle ,330 cases of normal newborn at the same time were regarded as the controls .Clinical data of birth defects were retrospectively analyzed ,and the possible factors associated with birth defects were evaluated by Logistic univariate and multivariate analysis .[Results]Com‐pared with the control group ,the proportion of high education ,high per capita income level ,and urban residence were lower in the observation group;the difference was statistically significant ( P < 0 .05 ) .Univariate analysis showed that smoking or alcohol drinking ,fever ,complications of pregnancy ,medication ,parity (counts of pregnancy and delivery) ,physical labor during pregnancy ,violence and chemical or X‐ray exposure ,adverse pregnancy history , and history of mental illness are risk factors for birth defects ,while pregnancy and premarital examinations ,good nu‐tritional condition ,and the use of folic acid are protective factors .Multivariate analysis also showed that the use of pregnancy and premarital tests were protective factors for birth defects ,while pregnancy complications ,exposure to chemicals or x‐ray ,and smoking or drinking alcohol were independent risk factors of birth defects and were statistical‐ly significant ( P <0 0.5) .[Conclusion]Birth defect is attributed to many factors .By means of advocating call for pre‐marital examination , pregnancy check‐up , reducing exposure to chemicals and other harmful substances in the periconceptional period and the occurrence of pregnancy complications ,the occurrence of birth defects can be reduced .%【目的】探讨围产儿出生缺陷的发生情况并分析与其相关的危险因素。【方法】选取2011

  12. Case-control study on physiological related factors on birth defects%生理相关因素对出生缺陷影响的病例对照研究

    Institute of Scientific and Technical Information of China (English)

    王香丽; 雷方良; 屈鹏飞; 李姗姗; 党少农

    2016-01-01

    Objective To explore the physiological related factors of birth defects .Methods A hospital based 1:2 matched case-control study was conducted among 147 cases of birth defects diagnosed in the First Affiliated Hospital of Xi ’ an Jiaotong University during the period of April 2009 to December 2013.Univariate and multivariate Logistic regression analyses were carried out to analyze the general condition, history of fertility, abnormal symptoms and disease during pregnancy .Results Univariate analysis results showed that advanced maternal age, frequent pregnancy, frequent spontaneous abortion, severe morning sickness, sickness history before and during pregnancy were the risk factors of birth defects .Multivariate Logistic regression analysis showed that severe morning sickness ( OR=2.197,95%CI:1.634-2.954), sickness before pregnancy (OR=2.089,95%CI:1.037-4.206) and during pregnancy (OR=1.562,95%CI:1.021-2.390 ) were the risk factors of birth defects .Conclusion Prenatal and perinatal health education should be strengthened .Great importance should be attached to prevent severe morning sickness and to carry out education and thorough treatment .The couples before marriage and pregnancy should be advocated to have physical examinations .Pregnancy care instruction should be provided aiming at different physical conditions of pregnant women , so as to effectively reduce the occurrence of birth defects and improve the birth quality .%目的:探讨出生缺陷的生理相关危险因素。方法收集2009年4月至2013年12月在西安交通大学第一附属医院诊断为出生缺陷的患儿147例,以医院为基础的1:2匹配病例对照研究,对产妇的一般情况、既往生育史、孕期异常状况及患病情况等资料,使用单因素分析和多因素条件Logistic回归进行比较分析。结果经单因素分析显示,高龄产妇、怀孕次数多、自然流产次数多、早孕反应严重、孕前和孕期有疾病史均为出生缺

  13. The Danish Heart Registry

    DEFF Research Database (Denmark)

    Özcan, Cengiz; Juel, Knud; Lassen, Jens Flensted

    2016-01-01

    AIM: The Danish Heart Registry (DHR) seeks to monitor nationwide activity and quality of invasive diagnostic and treatment strategies in patients with ischemic heart disease as well as valvular heart disease and to provide data for research. STUDY POPULATION: All adult (≥15 years) patients...

  14. Recent Decrease in the Prevalence of Congenital Heart Defects in Europe

    DEFF Research Database (Denmark)

    Khoshnood, Babak; Loane, Maria; Garne, Ester;

    2013-01-01

    OBJECTIVES: To examine trends in the prevalence of congenital heart defects (CHDs) in Europe and to compare these trends with the recent decrease in the prevalence of CHDs in Canada (Quebec) that was attributed to the policy of mandatory folic acid fortification. STUDY DESIGN: We used data...... for the period 1990-2007 for 47 508 cases of CHD not associated with a chromosomal anomaly from 29 population-based European Surveillance of Congenital Anomalies registries in 16 countries covering 7.3 million births. We estimated trends for all CHDs combined and separately for 3 severity groups using random...

  15. Analysis of influencing factors of birth defect based on health education%基于健康教育的出生缺陷影响因素分析

    Institute of Scientific and Technical Information of China (English)

    刘月芬; 李佳樾

    2012-01-01

    Teratogenic factors are closely related with living environment and human production and life, but are ignored easily. Therefore, the key link of reducing birth defect is to highlight public awareness effectively. This article indicated potential high-risk teratogenic factors in people' s life from the point of view of physics and chemistry so as to strengthen the concept of mass prevention and treatment and improve the effectiveness of preventing birth defects.%致畸因子与生存环境息息相关,其与人类生产生活密不可分,但却易被忽视.因此,降低出生缺陷至关重要的环节是有效地提高防范意识.该文从物理、化学等角度指出人们生活中潜在的高危致畸因素,强化群防群治理念,提高防范出生缺陷的效力.

  16. Five Facts about Congenital Heart Defects

    Science.gov (United States)

    ... Button Past Emails CDC Features Five Facts about Congenital Heart Defects Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir Congenital heart defects are the most common types of birth defects. ...

  17. Identifying associations between maternal medication use and birth defects using a case-population approach : an exploratory study on signal detection

    NARCIS (Netherlands)

    de Jonge, Linda; Zetstra-van der Woude, Priscilla A.; Bos, H. Jens; de Jong-van den Berg, Lolkje T. W.; Bakker, Marian K.

    2013-01-01

    Background The effects of many drugs on the unborn child are unknown. In a case-population design, drug exposure of cases is compared with that of a source population; this kind of study can be useful for generating signals. Objective To see whether a comparison of drug use rates from the birth defe

  18. 中枢神经系统出生缺陷相关因素的调查%Investigation on the Correlation Factors of Birth Defects of Central Nervous System

    Institute of Scientific and Technical Information of China (English)

    龙熙德; 丁华新; 舒仁和

    2009-01-01

    [Objective] To discuss the correlation factors of birth defects of central nervous system(CNS) in the area of Dongting Lake, and to provide the references for establishing intervention measures to prevent birth defects of CNS. [Methods] Among 89147 pregnant women who had been pregnant for at least 28 weeks and delivered after 7 days during the period from January 1997 to December 2006, mothers of 115 children patients who were confirmed to suffer from congenital malformation of CNS were collected as the case group. According to 1:2 matched, mothers of 230 normal newborns with the same condition were chosen as comparison group. Then, questionnaire investigation and match research were conducted. [Results] Family history of congenital malformation, father touching chemicals, fathers' drinking index, fever caused by cold, touching pesticide during pregnancy, smoking passively were main dangerous factors of birth defects of CNS, with OR value of 14.50, 10.10, 5.00, 4.53, 3.89 and 1.76, respectively. Education level, B-ultrasound in the middle of pregnancy and taking folic acid were protection factors, with βj value of -0.48, -2.36 and -2.51, respectively and OR value less than 1. The difference between scores of questionnaire of knowledge of birth defects obtained by patient case group and comparison group had statistical significance (P0.05). [Conclusion]Doing pre-marriage health education and pregnancy health care, and medically monitoring high risk population are keys to further reduce birth defects of CNS.%[目的]探讨中枢神经系统(CNS)出生缺陷的相关因素,为制定预防CNS出生缺陷干预措施提供参考依据.[方法]收集1997年1月至2006年12月期间孕满28周至产后7d的孕产妇89147例,其中确诊为CNS先天畸形患儿115例的母亲为病例组,按1:2配对,选取同等条件的230例正常新生儿的母亲为对照组,进行问卷调查、配对研究.[结果]先天畸形家族史、父接触化学物品、父饮酒指数、

  19. Rare birth defects associated with Morgagni hernia and segmental aplasia of uterine horn in bitch: Case reportDefeitos congênitos raros em cadela – relato de caso

    Directory of Open Access Journals (Sweden)

    Ricardo Santana de Lima

    2013-09-01

    Full Text Available Birth defects, deformities or abnormalities are terms used to describe developmental defects present at birth, most of which are rare in bitches. We report the case of a six-month old mongrel bitch corpse, which, when subjected to an anatomotopographic study revealed the presence of rare birth defects as Morgagni hernia and segmental aplasia of the right uterine horn with its attachment to the transverses muscle of abdominis. In association with HM, we observed the presence of dextrocardia and a defect of the abdominal wall supraumbilical characteristic of incompletely Pentalogy of Cantrell’s, syndrome so far described only in humans. In association with segmental aplasia of the uterine horn, we observed the ipsilateral presence of the renal hypoplasia and ureteral agenesis. The diagnosis of those abnormalities was based on anatomical findings and confirmed histologically. Despite the rarity and complexity of the abnormalities first described in bitches, the literature suggested that the prognosis may be favorable to the life of the animal. However, early diagnosis is essential to avoid the potential complications of those diseasesDefeitos congênitos, deformidades ou anormalidades são termos usados para descrever defeitos no desenvolvimento presentes ao nascimento. A maioria destes, como a aplasia segmentar uterina, é de ocorrência rara em cadelas. Relata-se o caso de um cadáver de cadela, sem raça definida, de seis meses de idade, que ao ser submetido ao estudo anatomotopográfico revelou a presença de aplasia segmentar uterina (ASU associada à hérnia de Morgagni (HM, agenesia ureteral (AU e hipoplasia renal direita (HR. Além destas anormalidades, foi observada a presença de dextrocardia e de um defeito da parede abdominal supraumbilical, que caracterizam a forma incompleta da pentalogia de Cantrell, só descrita em humanos. O diagnóstico destas anormalidades foi baseado nos achados anatômicos e confirmado histologicamente. A

  20. Monitoring of birth defects in Xixiang County in the period of 2008-2012%西乡县2008至2012年出生缺陷监测分析

    Institute of Scientific and Technical Information of China (English)

    张惠玲; 薛丽君

    2013-01-01

    目的了解西乡县出生缺陷的发生率、种类及动态变化情况,探索出生缺陷发生的相关因素,并采取针对性较强的干预措施,减少出生缺陷儿的发生。方法对西乡县22个镇卫生院2008至2012年上报的出生缺陷卡中孕28周到产后7天的围产儿资料进行回顾性分析。结果监测围产儿共15753例,出生缺陷儿92例,出生缺陷儿的发生率为5.84‰,5年出生缺陷发生率分别为4.56‰、6.63‰、6.93‰、5.03‰和5.87‰。男性与女性出生缺陷发生率、农村与城镇出生缺陷发生率比较均无显著性差异(χ2值分别为0.060和0.970,均P>0.05)。前5位出生缺陷依次为:唇腭裂、多指、先天性心脏病、神经管缺陷、先天性肛门闭锁。结论出生缺陷的干预应以预防为主,加强健康教育,普及优生优育知识,加强婚前、孕前、孕期保健指导,全面开展产前筛查、产前诊断、新生儿疾病筛查,做到早发现、早治疗、达到提高出生人口素质及生命质量的目的,是有效减少出生缺陷的根本途径。%Objective To understand the incidence , types and dynamic changes of birth defects in Xixiang County and explore the related factors, so as to take highly targeted interventions to reduce the incidence of birth defects .Methods Retrospective analysis was conducted on the data of perinatal infants from 28 weeks of pregnancy to 7 days after delivery reported by 22 county hospitals in Xixiang from 2008 to 2012.Results Of 15 753 monitored cases, 92 cases were reported with birth defects , and the incidence rate was 5.84‰.The incidence rate of these five years was 4.56‰, 6.63‰, 6.93‰, 5.03‰ and 5.87‰, respectively.There was no significant difference in the incidence of birth defects between male and female as well as urban and rural infants (χ2 value was 0.060 and 0.970, both P>0.05).The first five birth defects were cleft lip and palate

  1. Malaysian Twin Registry.

    Science.gov (United States)

    Jahanfar, Shayesteh; Jaffar, Sharifah Halimah

    2013-02-01

    The National Malaysian Twin Registry was established in Royal College of Medicine, Perak, University Kuala Lumpur (UniKL) in June 2008 through a grant provided by UniKL. The general objective is to facilitate scientific research involving participation of twins and their family members in order to answer questions of health and wellbeing relevant to Malaysians. Recruitment is done via mass media, poster, and pamphlets. We now have 266 adult and 204 children twins registered. Several research projects including reproductive health study of twins and the role of co-bedding on growth and development of children are carried out. Registry holds annual activities for twins and seeks to provide health-related information for twins. We seek international collaboration.

  2. Analysis of the report of perinatal birth defects monitoring in fengtai district of beijing from 2006 to 2010%北京市丰台区2006-2010年出生缺陷监测数据分析

    Institute of Scientific and Technical Information of China (English)

    唐艳; 张静; 房春玉

    2012-01-01

    Objective: By understanding the incidence of perinatal birth defect in Fengtai district of Beijing, in order to explore the influencing factors and develop interventions to reduce the incidence of birth defect. Methods; The data of perinatal birth defects from 2006 to 2010 were gathered from monitoring hospitals in Fengtai district. Results: The incidence of birth defect in Fengtai district was 110.5/10000 and there was a upward trend during 5 years. The perinatal birth defects stood on the first 3 rank of incidence list followed by Polydactyly, Congenital malformation of auricle, Congenital heart defects. There were certain correlation among birth defects, the mother's residence geography, gestational age, birth weight, gestational age of birth. Conclusion: It is valuable to reduce the incidence by a well - planned birth defects monitoring and preventive health care program.%目的 分析丰台区出生缺陷的发生情况及相关因素,探索降低出生缺陷发生的干预措施.方法 对2006~2010年北京市丰台区出生缺陷监测资料进行统计分析.结果 2006~2010年出生缺陷总发生率为110.5/万,各年的出生缺陷发生率呈上升趋势;按照出生缺陷病种分类,位于前3位的为多指(趾)、外耳畸形、先天性心脏病;男婴与女婴出生缺陷发生率比较具有显著性差异;母亲户籍、分娩年龄、婴儿出生体重、孕周等是出生缺陷发生的影响因素.结论 做好出生缺陷监测工作,加强出生缺陷三级预防,是降低出生缺陷发生的必要措施.

  3. 成都市某区六年来新生儿出生缺陷分析%The Analysis of Birth Defects of Newborns During the Past Six Years in a District of Chengdu

    Institute of Scientific and Technical Information of China (English)

    刘梅; 周礼英; 吴怀勇; 张志华; 张倩; 李青林; 汪渝; 杜彪; 王园

    2015-01-01

    Objective We studied puerperae from one district in Chengdu who registered, gave birth or had induced la-bor in our district during 2007 and 2013. For our sample,we investigated on subjects who had newborns with defects,or stillbirths. We summarized the factors on puerperae to have newborns with defects. We also summarized the examination methods and the de-velopment of newborn defects. We investigated newborns’ defects and the dynamic changes so that we can have a theoretical basis in preventing newborn defects. Methods We included puerperae from one district in Chengdu who registered,gave birth or had induced labor in our district during 2007 and 2013. All subjects were founded by using the registration information from pediatrics, obstetrics and health divisions. Puerperae with birth defects information were included. They were divided into two groups accord-ing to their due dates. We did retrospective survey on both groups,studied their medical records,and made records about puerperae who gave birth to defected newborns or had stillbirths. We used χ2test with collected data on both groups. Results During recent years,maternal health awareness might have increased. Puerperae in Group B were significantly better than puerperae in Group A in terms of premarital medical examinations,periodic medical examinations during pregnancy,and folic acid supplementation during pregnancy. Birth defects screening methods relied mainly on Down’s screening and fetal ultrasound examination. Birth defects were still mainly focused on eye,ear,face,or neck malformation,cryptorchidism,limbs,fingers or toes deformity. Conclusion During the past three years, chromosome abnormalities were found more frequently. It might suggest that there was a correlation with high-risk contacts.%目的:对成都市某区2007年至2013年在我区建卡、分娩或引产孕产妇,调查其中具有缺陷新生儿及死胎的产妇相关信息,总结近年来出生缺陷的产妇因素、检

  4. The Danish Schizophrenia Registry

    DEFF Research Database (Denmark)

    Baandrup, Lone; Cerqueira, Charlotte; Haller, Lea

    2016-01-01

    evaluation, antipsychotic treatment including adverse reactions, cardiovascular risk factors including laboratory values, family intervention, psychoeducation, postdischarge mental health care, assessment of suicide risk in relation to discharge, and assessment of global functioning. DESCRIPTIVE DATA......: The recorded data are available electronically for the reporting clinicians and responsible administrative personnel, and they are updated monthly. The registry publishes the national and regional results of all included quality measures in the annual audit reports. External researchers may obtain access...

  5. Disseminating Service Registry Records

    OpenAIRE

    A. Apps

    2006-01-01

    The JISC Information Environment Service Registry (IESR) contains descriptions of collections of resources available to researchers, learners and teachers in the UK, along with technical service access details. This paper describes the data model and metadata description schema of IESR, and the services IESR provides to disseminate its records. There is a particular focus on the Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH) interface, including a possible use scenario. I...

  6. The Brazilian Twin Registry.

    Science.gov (United States)

    Ferreira, Paulo H; Oliveira, Vinicius C; Junqueira, Daniela R; Cisneros, Lígia C; Ferreira, Lucas C; Murphy, Kate; Ordoñana, Juan R; Hopper, John L; Teixeira-Salmela, Luci F

    2016-12-01

    The Brazilian Twin Registry (BTR) was established in 2013 and has impelled twin research in South America. The main aim of the initiative was to create a resource that would be accessible to the Brazilian scientific community as well as international researchers interested in the investigation of the contribution of genetic and environmental factors in the development of common diseases, phenotypes, and human behavior traits. The BTR is a joint effort between academic and governmental institutions from Brazil and Australia. The collaboration includes the Federal University of Minas Gerais (UFMG) in Brazil, the University of Sydney and University of Melbourne in Australia, the Australian Twin Registry, as well as the research foundations CNPq and CAPES in Brazil. The BTR is a member of the International Network of Twin Registries. Recruitment strategies used to register twins have been through participation in a longitudinal study investigating genetic and environmental factors for low back pain occurrence, and from a variety of sources including media campaigns and social networking. Currently, 291 twins are registered in the BTR, with data on demographics, zygosity, anthropometrics, and health history having been collected from 151 twins using a standardized self-reported questionnaire. Future BTR plans include the registration of thousands of Brazilian twins identified from different sources and collaborate nationally and internationally with other research groups interested on twin studies.

  7. Air pollution and congenital heart defects.

    Science.gov (United States)

    Agay-Shay, Keren; Friger, Michael; Linn, Shai; Peled, Ammatzia; Amitai, Yona; Peretz, Chava

    2013-07-01

    Environmental factors such as ambient air pollution have been associated with congenital heart defects. The aim of this study was to investigate the association between gestational exposure to air pollution and the risk of congenital heart defects. We conducted a registry-based cohort study with a total of 135,527 live- and still-births in the Tel-Aviv region during 2000-2006. We used a Geographic Information System-based spatiotemporal approach with weekly inverse distance weighting modeling to evaluate associations between gestational exposure to ambient air pollution during weeks 3-8 of pregnancy and the risk for congenital heart defects. The following pollutants were studied: carbon monoxide, nitrogen-dioxide, ozone, sulfur-dioxide and particulate matter with aerodynamic diameter smaller than 10 μm and 2.5 μm (PM10, PM2.5 respectively). Logistic models, adjusted for socio-demographic covariates were used to evaluate the associations. We found that maternal exposure to increased concentrations of PM10 was associated with multiple congenital heart defects (adjusted OR 1.05, 95% CI: 1.01 to 1.10 for 10 μg/m(3) increment). An inverse association was observed between concentrations of PM2.5 and isolated patent ductus arteriosus (adjusted OR 0.78, 95% CI: 0.68 to 0.91 for 5 µg/m(3) increment). Sensitivity analyses showed that results were consistent. Generally there were no evidence for an association between gaseous air pollutants and congenital heart defects.Our results for PM10 and congenital heart defects confirm results from previous studies. The results for PM2.5 need further investigations.

  8. Preterm Birth

    Science.gov (United States)

    ... is born too early, before 37 weeks of pregnancy have been completed. In 2015, preterm birth affected about 1 of every 10 infants born in the United States. Preterm birth rates decreased from 2007 to 2014, and CDC research shows ...

  9. 北京平谷区三年出生缺陷产前超声筛查分析%Prenatal Ultrasound Screening Analysis for the Birth Defects within 3 Years in Pinggu District in Beijing

    Institute of Scientific and Technical Information of China (English)

    刘大平

    2013-01-01

    Objective Ultrasonography in prenatal screening for birth defects diagnosis,understanding of the region the incidence of birth defects,in order to reduce the occurrence of congenital malformation.Methods In 2007,2008,my area,2009 (statistical time for every year from October 1st to next September 30th) delivery within seven days after the diagnosis of birth defects and ultrasound examination results were analyzed.Results In three years the region a total of 162 infants with birth defects,a total of 60 cases of prenatal ultrasound screening detected fetal malformation,and confirmed after birth ultrasound diagnosis correctly,ultrasound screening for the detection rate for 37 %.Missed diagnosis of malformations mainly for cardiac malformation in 45 cases,means (toe) abnormalities in 26 cases,lip,palate 8 cases.Conclusions Ultrasound examination can be detected in the vast majority of congenital fetal malformations,at present this area for gastroschisis,anencephaly and other obvious fetal malformation high detection rate,on minor malformations such as finger (toe) abnormalities in three years has never been detected,on fetal cardiac abnormalities by ultrasonography technology needs to be further improved.%目的 探讨超声产前筛查对出生缺陷的诊断价值,了解本地区出生缺陷的发生动态,为减少先天畸形的发生提供依据.方法 将平谷区2007-2009年(统计时间为每年10月1日至次年9月30日)分娩后7d内诊断的出生缺陷儿与超声检查结果,进行对比分析.结果 3年全区共分娩畸形儿162例,产前超声共筛查出60例畸形胎儿,且出生后证实超声诊断正确,超声筛查的检出率为37%.漏诊心脏畸形45例,指(趾)异常26例,唇、腭裂8例等.结论 超声检查可以检出绝大多数的胎儿先天畸形,目前平谷区对腹裂、无脑儿等明显的胎儿畸形检出率高,对微小畸形如指(趾)异常3年从未检出过,对胎儿心脏异常的超声检查技术有待进一步提高.

  10. Birth Defects in Infants Born in 1998-2004 to Men and Women Serving in the US Military During the 1990-1991 Gulf War Era

    Science.gov (United States)

    2012-08-18

    exposure data and in-theater medical care were linked to birth data to investigate the potential for long-term teratogenicity of specific exposures...the National Personnel Records Center database. Furthermore, few data were available regarding other possible teratogens , such as depleted uranium...Arfsten et al., 2001), or known teratogens , such as smoking (Werler et al., 2005), alcohol consumption (Larkby and Day, 1997), and pesticide expo- sure

  11. The effect of health education on preventing birth defects in a community of Nanjing City%南京市社区预防出生缺陷健康教育的效果评价

    Institute of Scientific and Technical Information of China (English)

    许碧云; 胡娅莉; 崔晓宁; 姚敬; 洪红

    2012-01-01

    目的 评价南京市鼓楼区预防出生缺陷健康教育的效果,为以社区为基础的出生缺陷一级预防提供科学依据.方法 选择2008年3月~2009年7月在南京市鼓楼区建围产期保健小卡的孕妇作为调查对象并进行出生缺陷相关知识宣传教育,采用问卷调查早孕人群干预前后出生缺陷知识、态度和行为的变化,分析其影响因素.结果 干预后早孕人群对预防出生缺陷相关知识的总得分(34.43±3.10)高于干预前(29.56±4.77) (t=58.50,P<0.001).干预后21道题目回答正确率均高于干预前,其中仅1道题干预前后正确率的差异无统计学意义(P=0.458).年龄、文化程度、职业和家庭人均月收入对干预效果都有明显的影响(均有P<0.05).年龄大者比年龄小者,本科及以上文化程度比初中及以下者,医护人员比工人,家庭人均月收入1 001 ~元、2 001~元、3 001~元、4 001~元、≥5 001元比≤1 000元者对知识的掌握明显增多.结论 利用健康教育的模式对早孕人群进行干预,能提高其预防出生缺陷的能力.应对文化程度偏低、家庭收入较少的育龄妇女进行预防出生缺陷知识的普及.%Objective To evaluate the effect of health education on preventing birth defects in Gulou District of Nanjing City, in order to provide scientific evidence for the first-level prevention of the birth defect based on community. Methods Health education was conducted among the pregnant women who build card of perinatal health during March 2008 to July 2009 in Gulou District of Nanjing City. The questionnaire was used to investigate the knowledge, attitude and practice of birth defect prevention among the early pregnant women. The results were analyzed to find the changes of knowledge , attitude and practice of birth defect prevention before- and after- intervention, and to find the influencing factors of intervention effect. Results There was significant promotion (i = 58. 50

  12. Effect analysis of the surveillance and intervention of severe birth defects on decreasing the incidence of live birth with Down's syndrome in Zhongshan%中山地区重大出生缺陷监控和干预措施的实施对降低唐氏综合征出生率的效果分析

    Institute of Scientific and Technical Information of China (English)

    王莹; 江陵; 吴剑波; 陈昂; 陈咏莲; 李莉敏

    2012-01-01

    Objective; To analysize the effect of the surveillance and intervention of severe birth defects on decreasing the incidence of live birth with Down's syndrome in Zhongshan, 2010 -2011. Methods; Prenatal screening of Down's syndrome has been free in residents since January 1, 2010. The Surveillance and Intervention were carried out at the same time. Data of the surveillance were analyzed, 2008 -2011 , comparing the difference of the incidences. Results; After the surveillance and intervention, the rate of prenatal diagnosis of Down's syndrome increased significantly. The rate of live births with Down's syndrome decreased in 2010 -2011 (1. 63 -0. 64/ten thousand) compared with 2008 and 2009 (3. 5-3. 78/ten thousand). Conclusion; The Surveillance and intervention of severe birth defects on were effective on decreasing the incidence of live birth with Down's syndrome in Zhongshan.%目的 分析2010年-2011年中山地区对重大出生缺陷采取的监控和干预措施在降低唐氏综合征出生率方面的实际效果.方法 2010年1月1日始中山市对户籍人口实施免费产前筛查唐氏综合征,并进行监控和干预措施,通过2008年-2011年中山市出生缺陷监测网监测唐氏综合征儿数据,比较唐氏综合征出生率的差异.结果 实施重大出生缺陷监控和干预措施后,唐氏综合征的产前诊断率显著提高,唐氏综合征出生率2010年-2011年(1.63-0.64/万)较2008年-2009年(3.5-3.78/万)有明显下降(P =0.001).结论 2010年-2011年中山市对重大出生缺陷采取监控和干预措施在降低唐氏综合征出生率方面起到很好的效果.

  13. Estudo de prevalência de defeitos congênitos no Vale do Paraíba Paulista Prevalence study of birth defects in Vale do Paraíba, São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Cilene Otaviano Pinto

    2007-09-01

    Full Text Available OBJETIVO: Estimar a prevalência de anomalias congênitas no Vale do Paraíba Paulista em 2002 e 2003. MÉTODOS: Estudo transversal com base em dados constantes na Declaração de Nascido Vivo (DNV, cujas informações estavam no portal da Secretaria da Saúde do Estado de São Paulo. As malformações foram descritas de acordo com o capítulo XVII do Código Internacional de Doenças (CID 10, referente a variáveis maternas e do recém-nascido. A variável desfecho (dependente foi a presença de anomalia congênita; as demais informações das mães e do recém-nascido constantes na DNV (variáveis independentes foram analisadas para estimar as associações entre elas e a variável desfecho. Utilizou-se o programa Epi-Info 6.04d para análise estatística e o teste do qui-quadrado, do qui-quadrado de tendência linear e o teste t de Student. RESULTADOS: Foram analisados 41.838 dados com informações constantes nas DNVs, sendo identificados 618 (1,5% sem preenchimento do campo correspondente à anomalia congênita e 317 (0,76% nascidos com anomalia congênita. Houve associação positiva de anomalias congênitas com menor duração da gestação, maior número de filhos mortos, tipo de parto, baixo peso ao nascer e menor escore de Apgar. Os sistemas mais afetados foram o osteomuscular e o nervoso. CONCLUSÕES: A prevalência de malformações foi menor que a encontrada em outros estudos, possivelmente por sub-registro de informação.OBJECTIVE: Estimate the prevalence of birth defects in the Vale do Paraíba Paulista, São Paulo - Brazil, during the years of 2002 and 2003. METHODS: Cross-sectional study based on Birth Certificates available in the São Paulo Health Secretary site. The abnormalities were described according to chapter XVII of the International Classification of Diseases and Related Health Problems (ICD 10 for variables related to mothers and infants born alive at birth. The dependent variable was the presence of abnormalities

  14. Playing the role of preventing and curing birth defects in the second grade general hospitals%发挥二级综合医院在防治出生缺陷中的作用

    Institute of Scientific and Technical Information of China (English)

    张园园; 蔡慧兰; 吴晨

    2013-01-01

    目的 通过对6个县市二级综合医院产前筛查等情况进行调查研究,探讨预防出生缺陷的新途径.方法 采取定性定量相结合的办法、访谈法、问卷调查法等.结果 二级综合医院开展遗传咨询、产前筛查、产前诊断、新生儿疾病筛查等方面工作做得不够,婚检和婚前保健工作存在薄弱环节.结论 我国出生缺陷总发生率呈上升趋势,加强二级综合医院妇产科建设,充分发挥其产前筛查、遗传咨询、产前诊断职能,有利于帮助解决出生缺陷这一突出的公共卫生问题.%Objective To investigate and study the conditions of prenatal screening and other items in the second grade general hospitals of six counties and cities, and to explore a new way to prevent birth defects. Methods A combination of qualitative and quantitative ways, interviews, questionnaires and other approaches were taken. Results Carrying out genetic counseling, prenatal screening & diagnosis, neonatal disease screening and other items were not good enough in the second grade general hospitals. Meanwhile, the antemarital physical examination and premarital health service had weaknesses. Conclusion The total incidence rate of birth defects in China increases in the ascendant trend. Therefore, it is vital to strengthen the construction of the department of obstetrics and gynecology in the second grade general hospitals, and the hospitals should fully display its functional role in prenatal screening, genetic counseling, prenatal diagnosis which can help resolve the prominent public health problem of birth defects.

  15. Bladder Exstrophy : An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature

    NARCIS (Netherlands)

    Siffel, Csaba; Correa, Adolfo; Amar, Emmanuelle; Bakker, Marian K.; Bermejo-Sanchez, Eva; Bianca, Sebastiano; Castilla, Eduardo E.; Clementi, Maurizio; Cocchi, Guido; Csaky-Szunyogh, Melinda; Feldkamp, Marcia L.; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Marengo, Lisa K.; Mastroiacovo, Pierpaolo; Morgan, Margery; Mutchinick, Osvaldo M.; Pierini, Anna; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Olney, Richard S.

    2011-01-01

    Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We us

  16. Experience of reasons and intervention measures of 7 cases of birth defects of multi finger(toe)%出生缺陷多指(趾)儿7例原因分析及干预措施

    Institute of Scientific and Technical Information of China (English)

    呙明蓉

    2014-01-01

    目的:探讨出生缺陷多指(趾)儿的原因及干预措施。方法:2009年10月-2013年9月收治出生缺陷多指(趾)儿7例,针对其发生率、孕周、胎儿性别、孕妇的年龄、文化程度、孕早期情况、出生缺陷、转归等7个方面进行统计及分析。结果:发生率:出生缺陷儿的发生率70.63‰,围产儿的死亡率32.60‰;多指(趾)儿发生率26.92%,围产儿存活率100%。孕周:37周1例,38周3例,39周2例,40周1例,7例均为足月产。胎儿性别:男4例,女3例,性别没有差异。孕妇年龄:26岁1例,27岁1例,28岁2例,29岁2例,30岁1例,孕妇年龄没有差别。文化程度:小学1例,初中3例,大专3例。孕早期情况:感冒1例,发热1例,无异常5例。畸形部位:多指5例,多趾1例,右足并趾1例。转归:活产7例,均为活产。结论;对7例出生缺陷儿的原因分析,加强对优生优育的宣教,避免不良生活习惯,避免孕早期病毒感染和孕期的保健,提高生存质量的重要措施。%Objective:To explore the reasons and intervention measures of birth defects of multi finger(toe).Methods:7 cases with birth defects of multi finger(toe) were selected from October 2009 to September 2013.We analyzed the incidence,gestational weeks,fetus gender,maternal age,culture degree,early pregnancy,birth defects and prognosis.Results:The incidence rate of birth defects in children was 70.63‰,and perinatal mortality was 32.60‰.Multi finger(toe) rate was 26.92%,and the perinatal survival rate was 100%.Gestational age:1 case was 37 weeks,3 cases were 38 weeks,2 cases were 39 weeks,1 case were 40 weeks,7 cases were all full-term birth.The sex of the fetus:4 cases were male,3 cases were female,there was no gender differences.Age of pregnant women:1 case was 26 years old,1 case was 27 years old,2 cases were 28 years old,2 cases were 29 years old,1 case was 30 years old,there was no difference in

  17. Outcomes Among Pregnant Women Included in the Operation TOMODACHI Registry

    Science.gov (United States)

    2013-02-12

    Table 1 shows the status of potentially-exposed pregnancies. Pregnancy outcomes include live delivery, spontaneous loss, and induced abortion ...birth defects, which are defined according to the Case Definition of the National Birth Defects Prevention Network.3 Additional uses for these data...pregnancy outcome in the electronic medical data/records. Overall, the live delivery rates are quite high and the spontaneous loss rates are quite

  18. 2007-2014年潍坊市寒亭区围产儿出生缺陷监测结果分析%Analysis on monitoring results of perinatal birth defects in Hanting District of Weifang city from 2007 to 2014

    Institute of Scientific and Technical Information of China (English)

    杨丽; 张毅; 郭文星; 王立洁

    2016-01-01

    Objective To analyze the monitoring results of perinatal birth defects in Hanting District of Weifang city,put forward suggestions for prevention of birth defects in the region.Methods The monitoring data of perinatal birth defects from January 1 st,2007 to December 31st,2014 were researched,SPSS software was used for statistical analysis.Results From 2007 to 2014,there were 29 142 perinatal infants in the region,113 infants were diagnosed as birth defects,the average incidence rate of birth defects was 3.88‰.The top five types of birth defects were polydactylism,total cleft lip and palate,congenital heart disease,deformity,and hydrocephalus.Conclusion The incidence rate of birth defects in Hanting District of Weifang city in recent years showed a decreasing trend,corresponding intervention measures should be taken according to the change of rank of birth defects.%目的 分析潍坊市寒亭区出生缺陷的监测结果,有针对性地对该地区出生缺陷的预防提出建议.方法 研究2007年1月1日-2014年12月31日所有妊娠从28周到产后7d的围产儿的出生缺陷监测资料,用SPSS软件对围产儿出生缺陷医院监测资料进行统计分析.结果 2007-2014年该地区共有围产儿29 142例,出生缺陷113例,出生缺陷的平均发生率为3.88‰,前5位出生缺陷类型依次为多指(趾),总唇腭裂,先天性心脏病,总畸形和脑积水.结论 潍坊市寒亭区近几年出生缺陷的发生率总体呈下降趋势,应针对出生缺陷顺位统计的变化采取有针对性的干预措施.

  19. Birth outcomes of cases with unclassified multiple congenital abnormalities and pregnancy complications in their mothers depending on the number of component defects. Population-based case-control study.

    Science.gov (United States)

    Puhó, Erzsébet H; Czeizel, Andrew E; Acs, Nándor; Bánhidy, Ferenc

    2008-09-01

    Multiple congenital abnormalities (MCA) represent the most severe category of structural birth defects, (i.e. congenital abnormalities [CA]). Unfortunately, most MCA are not recognized and/or identified as MCA syndromes or MCA associations in the clinical practice. The term unclassified MCA (UMCA) is used for this category of MCA. We decided to evaluate the component CA of UMCA cases. The population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities (1980-1996) was evaluated. 'False' MCA, such as complex CA, polytopic field defects and sequences were excluded from the category of MCA. In addition, MCA syndromes caused by chromosomal aberrations and major mutant genes with preconceptional origin were excluded from the dataset of the Surveillance. MCA syndromes caused by teratogens and MCA associations with well-defined component CA were also excluded in the study. Thus, only UMCA cases (i) without the recognition of previously delineated MCA syndromes (ii) and/or without the identification of new MCA syndromes or (iii) caused by random combination of CA were included in the study. We compared data from 1349 cases with UMCA, 2405 matched population controls without any CA, and 21 494 malformed controls with isolated CA. There was a higher rate of stillbirth and a moderate male excess in UMCA cases, a somewhat shorter gestational age at delivery and an obvious reduction in birthweight. The intrauterine fetal growth retardation and rate of low-birthweight newborns showed an association with the number of component CA in UMCA cases. A similar association was not found with gestational age and the rate of preterm birth. UMCA represent one of the most severe categories of CA. The degree of intrauterine fetal growth retardation depends on number of component CA in UMCA cases.

  20. The New ADL Registry. ADL Registry Web Portal Changes

    Science.gov (United States)

    2009-08-19

    Approaches 18 19 Primary ADL Registry Contributors Contributor Records Entry Date Navy eLearning (US Navy) 2,086 08/05/2008 Joint Knowledge Development...ADL Registry  http://adlregistry.adlnet.gov/  Navy eLearning Content Team  https://www.netc.navy.mil/ile  Joint Knowledge Online  http

  1. Analysis on Effect of Thalassemia Interventions on Prevention of Birth Defects%地中海贫血干预措施预防出生缺陷的效果分析

    Institute of Scientific and Technical Information of China (English)

    王远流; 刘百灵; 樊钰辰

    2013-01-01

    目的:探讨地中海贫血干预措施预防出生缺陷的效果。方法对门诊所有产检孕妇及其丈夫27076例进行地中海贫血相关知识宣教,同时进行地中海贫血筛查,双方筛查阳性的夫妇均进行地中海贫血基因诊断,对高风险的孕妇进行产前诊断,确诊重型地中海贫血胎儿者建议终止妊娠。结果共筛查27076例,其中建卡孕妇筛查14877例,丈夫筛查12199例。地贫筛查双方均阳性的夫妇341对,其中高风险的孕妇148例进行产前诊断,确诊重型地中海贫血胎儿28例,均引产。结论孕期地中海贫血干预可以避免重度地中海贫血胎儿的出生,从而降低出生缺陷发生率。%Objective To investigate the effect of thalassemia interventions on the prevention of birth defects . Methods We performed the publicity and education of thalassemia-related knowledge in 27 076 cases ( including pregnant women and their husbands ) as well as a thalassemia screening in prenatal clinic .The couples whose thalassemia screening results showed positive were given a thalassemia gene diagnosis for both and prenatal diagnosis for high-risk pregnant women.The pregnant women with thalassemia major fetus were suggested to terminate pregnancy .Results A total of 27 076 cases were enrolled in the thalassemia screening ,including 14 877 pregnant women building the card and 12 199 husbands.The thalassemia screening results were positive for 341 couples.One hundred and forty-eight cases of high-risk pregnant women were given a prenatal diagnosis ,and 28 confirmed thalassemia major fetuses received induction of labor.Conclusion The thalassemia intervention during pregnancy can avoid the birth of thalassemia major fetuses , thereby it can reduce the incidence of birth defects .

  2. Living with a Congenital Heart Defect

    Science.gov (United States)

    ... to the dentist also can help prevent IE. Birth Control and Pregnancy Women who have heart defects should ... with their doctors about the safest type of birth control for them. Many of these women can safely ...

  3. Birth Injury

    Science.gov (United States)

    ... Commentary Recent News Scientists Working on Solar-Powered Prosthetic Limbs Exercise a Great Prescription to Help Older Hearts Bavencio Approved for Rare Skin Cancer Older Mothers May Raise Better-Behaved Kids, Study ... lying in an abnormal position in the uterus before birth. Overall, the rate of birth injuries is much lower now than in previous decades because of improved ...

  4. Birth Weight

    Science.gov (United States)

    ... baby, taken just after he or she is born. A low birth weight is less than 5.5 pounds. A high ... weight is more than 8.8 pounds. A low birth weight baby can be born too small, too early (premature), or both. This ...

  5. The Danish Twin Registry

    DEFF Research Database (Denmark)

    Skytthe, Axel; Christiansen, Lene; Kyvik, Kirsten Ohm;

    2013-01-01

    decade of combining questionnaire and survey data with national demographic, social, and health registers in Statistics Denmark. Second, we describe our most recent data collection effort, which was conducted during the period 2008-2011 and included both in-person assessments of 14,000+ twins born 1931......Over the last 60 years, the resources and the research in the Danish Twin Registry (DTR) have periodically been summarized. Here, we give a short overview of the DTR and a more comprehensive description of new developments in the twenty-first century. First, we outline our experience over the last......-1969 and sampling of biological material, hereby expanding and consolidating the DTR biobank. Third, two examples of intensively studied twin cohorts are given. The new developments in the DTR in the last decade have facilitated the ongoing research and laid the groundwork for new research directions....

  6. Danish National Lymphoma Registry

    DEFF Research Database (Denmark)

    Arboe, Bente; Josefsson, Pär; Jørgensen, Judit;

    2016-01-01

    AIM OF DATABASE: The Danish National Lymphoma Registry (LYFO) was established in order to monitor and improve the diagnostic evaluation and the quality of treatment of all lymphoma patients in Denmark. STUDY POPULATION: The LYFO database was established in 1982 as a seminational database including...... all lymphoma patients referred to the departments of hematology. The database became nationwide on January 1, 2000. MAIN VARIABLES: The main variables include both clinical and paraclinical variables as well as details of treatment and treatment evaluation. Up to four forms are completed for each...... patient: a primary registration form, a treatment form, a relapse form, and a follow-up form. Variables are used to calculate six result quality indicators (mortality 30 and 180 days after diagnosis, response to first-line treatment, and survival estimates 1, 3, and 5 years after the time of diagnosis...

  7. 2009-2010年北京市西城区德胜社区出生缺陷监测情况%Monitoring and analysis on birth defects in Desheng community in Xicheng district of Beijing 2009-2010

    Institute of Scientific and Technical Information of China (English)

    褚喆萍; 薄新生; 纪晋文

    2012-01-01

    目的 了解北京市西城区德胜社区出生缺陷发生特点,为干预措施提供科学依据.方法 对2009-2010年北京市西城区德胜社区的人群出生缺陷监测结果进行分析.结果 2009、2010年德胜社区出生缺陷发生率分别为25.91%、22.58%,出生缺陷发生顺位前3位的分别是先天性心脏病(52.50%)、外耳其他畸形(15.00%)、并指(趾)(10.00%),出生缺陷发生与孕周、孕妇年龄有关(P<0.05),出生缺陷的诊断手段主要为B超和临床.结论 要关注高龄孕妇围生期保健,做好孕产妇系统管理,规范产前检查和预防,降低出生缺陷发生率.%[Objective]To investigate the epidemiological characteristics of birth defects in Desheng community in Xicheng District of Beijing, provide the scientific basis for intervention measures. [Methods] The monitoring results of birth defects in Desheng community in Xicheng District of Beijing during 2009-2010 were analyzed. [Results] The incidence rate of birth defects in Desheng community in 2009 and 2010 was 25. 91‰ and 22. 58‰ respectively. The top three birth defects were congenital heart disease (52.50% ), congenital external ear malformations (15.00% ) and syndactyly (10.00% ). The birth defects were related to gesta-tional age and maternal age (P <0. 05). The main diagnostic methods of birth defects were B-ultrasound and clinical diagnosis. [Conclusion] It is necessary to pay attention to perinatal health care among senile gravida, carry out the system management among pregnant women, and improve the prenatal examination and prevention, in order to reduce the incidence rate of birth defects.

  8. Prevalence of Birth Defects Among Infants of Gulf War Veterans in Arkansas, Arizona, California, Georgia, Hawaii, and Iowa, 1989-1993

    Science.gov (United States)

    2003-01-01

    microtia 0 0 Common truncus 0 0 Transposition of great arteries 0 1 5.0 (0.3-32.3) Tetralogy of Fallot 0 4 19.9 (6.4-54.7) Ventricular septal defect 0...0.1-9.5) 9 5.0 (2.5-9.9) 0.3 (0.04-2.3) Congenital cataract 2 2.9 (0.5-11.7) 3 1.7 (0.4-5.3) 1.7 (0.3-10.4) Aniridia 0 0 "Anotia/ microtia 1 1.5 (0.1...cataract 0 0 Aniridia 0 0 Anotia/ microtia 0 1 5.1 (0.3-33.1) Common truncus 0 0 Transposition of great arteries 0 0 Tetralogy of Fallot 0 1 5.1 (0.3-33.1

  9. Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review.

    Directory of Open Access Journals (Sweden)

    Ibrahim Zaganjor

    Full Text Available Folate-sensitive neural tube defects (NTDs are an important, preventable cause of morbidity and mortality worldwide. There is a need to describe the current global burden of NTDs and identify gaps in available NTD data.We conducted a systematic review and searched multiple databases for NTD prevalence estimates and abstracted data from peer-reviewed literature, birth defects surveillance registries, and reports published between January 1990 and July 2014 that had greater than 5,000 births and were not solely based on mortality data. We classified countries according to World Health Organization (WHO regions and World Bank income classifications. The initial search yielded 11,614 results; after systematic review we identified 160 full text manuscripts and reports that met the inclusion criteria. Data came from 75 countries. Coverage by WHO region varied in completeness (i.e., % of countries reporting as follows: African (17%, Eastern Mediterranean (57%, European (49%, Americas (43%, South-East Asian (36%, and Western Pacific (33%. The reported NTD prevalence ranges and medians for each region were: African (5.2-75.4; 11.7 per 10,000 births, Eastern Mediterranean (2.1-124.1; 21.9 per 10,000 births, European (1.3-35.9; 9.0 per 10,000 births, Americas (3.3-27.9; 11.5 per 10,000 births, South-East Asian (1.9-66.2; 15.8 per 10,000 births, and Western Pacific (0.3-199.4; 6.9 per 10,000 births. The presence of a registry or surveillance system for NTDs increased with country income level: low income (0%, lower-middle income (25%, upper-middle income (70%, and high income (91%.Many WHO member states (120/194 did not have any data on NTD prevalence. Where data are collected, prevalence estimates vary widely. These findings highlight the need for greater NTD surveillance efforts, especially in lower-income countries. NTDs are an important public health problem that can be prevented with folic acid supplementation and fortification of staple foods.

  10. Tools and data services registry

    DEFF Research Database (Denmark)

    Ison, Jon; Rapacki, Kristoffer; Ménager, Hervé

    2016-01-01

    at hand.Here we present a community-driven curation effort, supported by ELIXIR-the European infrastructure for biological information-that aspires to a comprehensive and consistent registry of information about bioinformatics resources. The sustainable upkeep of this Tools and Data Services Registry...... is assured by a curation effort driven by and tailored to local needs, and shared amongst a network of engaged partners.As of September 2015, the registry includes 1633 resources, with depositions from 91 individual registrations including 40 institutional providers and 51 individuals. With community support...

  11. Iranian Joint Registry (Iranian National Hip and Knee Arthroplasty Registry).

    Science.gov (United States)

    Aslani, Hamidreza; Nourbakhsh, Seyed Taghi; Lahiji, Farivar A; Heydarian, Keykavoos; Jabalameli, Mahmood; Ghazavi, Mohammad Taghi; Tahmasebi, Mohammad Naghi; Fayyaz, Mahmoud Reza; Sazegari, Mohammad Ali; Mohaddes, Maziar; Rajabpour, Mojtaba; Emami, Mohammad; Jazayeri, Seyyed Mohammad; Madadi, Firooz; Farahini, Hossein; Mirzatoloee, Fardin; Gharahdaghi, Mohammad; Ebrahimzadeh, Mohammad Hossein; Ebrahimian, Mohammadreza; Mirvakili, Hossein; Bashti, Kaveh; Almasizadeh, Mohtasham; Abolghasemian, Mansour; Taheriazam, Afshin; Motififard, Mehdi; Yazdi, Hamidreza; Mobarakeh, Mahmood Karimi; Shayestehazar, Masoud; Moghtadae, Mehdi; Siavashi, Babak; Sajjadi, Mohammadreza M; Rasi, Alireza Manafi; Chabok, Seyyed Kazem; Zafarani, Zohreh; Salehi, Shahin; Ahmadi, Monireh; Mohammadi, Amin; Shahsavand, Mohammad Ebrahim

    2016-04-01

    Periodic evaluation and monitoring the health and economic outcome of joint replacement surgery is a common and popular process under the territory of joint registries in many countries. In this article we introduce the methodology used for the foundation of the National Iranian Joint Registry (IJR) with a joint collaboration of the Social Security Organization (SSO) and academic research departments considering the requirements of the Iran's Ministry of Health and Education.

  12. 孕前风险评估对出生缺陷的影响分析%Impact Analysis of Pre Pregnancy Risk Assessment on the Effect of Birth Defects

    Institute of Scientific and Technical Information of China (English)

    张国荣; 张红; 肖桂梅

    2015-01-01

    目的:探讨实施育龄妇女孕前风险评估对降低出生缺陷的干预效果。方法选择在我院进行免费孕前筛查的650例育龄妇女为干预组,进行孕前风险评估;随机抽取650例在县人民医院住院分娩,且未进行孕前风险评估的产妇为对照组。比较两组观察对象优生知识知晓情况、孕期营养指导、叶酸服用及出生缺陷发生情况等。结果干预组对象优生知识知晓率、孕期营养指导率、叶酸服用率均明显优于对照组,差异有统计学意义( P<0.05)。干预组围产儿出生缺陷的发生率为4.6‰(3/650),明显低于对照组的12.3‰(8/650),差异具有统计学意义( P<0.05)。结论孕前风险评估可有效识别出育龄妇女自身存在的危险因素,通过采取有针对性的干预,有效降低了出生缺陷率。%Objective To investigate the effect of intervention on implementation of pre pregnant women risk assessment on the effect of thebirthdefects.Methods 650casesofreproductiveagewomenoffreescreeningbeforepregnancyinthehospitalwereselectedasthein-tervention group , and the pre pregnancy risk assessment on them was done .650 patients in county -level people′s hospital who did not carry out pre pregnancy risk assessment were randomly selected as the control group .The eugenic knowledge , nutrition guidance during pregnancy , folic acid and birth defects incidence between the two groups were compared .Results Through comparing with the control group , the eugenic knowledge rate , nutrition guidance during pregnancy rate , the rate of folic acid in the intervention group were significant-ly better than that of the control group , and the difference was statistically significant (P<0.05).The perinatal birth defects incidence rate of intervention group was 4.6‰(3/650), and it was significantly lower than that of the control group of 12.3‰(8/650), with significant difference (P<0.05).Conclusion

  13. 江西省铅山地区出生缺陷监测结果分析及干预措施探讨%Analysis on birth defects monitoring result and discussion on its interventions in Yanshan county of Jiangxi Province

    Institute of Scientific and Technical Information of China (English)

    余愔; 陈祖林

    2012-01-01

    Objective: Birth defects situation in Yanshan County of Jiangxi Province were analyzed to provide the scientific basis for establishing interventions against birth defects. Methods: The monitoring database collected by Yanshan Medical and Health Service and Family Planning Service Station about 20 150 cases of perinatal fetus born from January 2004 to December 2009 in this area were analyzed by adopting epidemiological method based on population through three - stage network of women and children. Results: There were 20 150 cases of live births, 183 cases of perinatal fetus with birth defects and birth defects rate was 9. 08‰. The top sequent 5 birth defects are congenital; heart disease, congenital hydrocephalus, polydactylism, congenital deafness and cheilopalatognathus sequent. Conclusion: Birth defects rate can be reduced by strengthening pre - pregnancy monitoring and health education for maternal with prevention first to improve antenatal diagnosis technology and perform termination of pregnancy timely.%目的 分析江西省铅山县出生缺陷的发生情况,为本地区制定出生缺陷预防措施提供科学依据.方法 利用妇幼三级网络,采用以人群为基础的流行病学调查方法搜集出生缺陷资料,对2004年1月~2009年12月全县医疗保健单位和县计生服务站在该地区出生的围产儿共20 150例监测数据库资料进行分析.结果 活产儿20 150例,围产儿出生缺陷183例,出生缺陷发生率为9.08%.其前5顺位是先天性心脏病心(先心)、先天性脑积水、多指(趾)、先天性耳聋、唇腭裂.结论 加强孕前监测和孕产妇的孕前健康教育,预防为主,提高产前诊断技术,适时终止妊娠,可有效降低出生缺陷的发生率.

  14. DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues.

    Science.gov (United States)

    Liu, L; Wells, P G

    1995-11-01

    A considerable number of teratogens, including the anticonvulsant drug phenytoin and structurally related drugs and environmental chemicals, may be bioactivated by peroxidases, such as prostaglandin H synthase (PHS) and lipoxygenases (LPOs), to a reactive free radical intermediate that initiates birth defects. However, the molecular targets of the reactive free radical intermediates mediating chemical teratogenesis, and hence the fundamental determinants of susceptibility, are poorly understood. In these studies, a teratogenic dose of phenytoin (65 mg/kg), when injected into pregnant CD-1 mice during organogenesis on gestational day 12, initiated the oxidation of DNA in maternal hepatic and embryonic nuclei, forming 8-hydroxy-2'-deoxyguanosine. Significant maternal and embryonic DNA oxidation occurred at 6 and 3 h, respectively, suggesting relative embryonic deficiencies in free radical-related cytoprotective enzymes, although the rates appeared similar. Maximal DNA oxidation in both maternal and embryonic tissues occurred at 6 h, presumably reflecting the balance of DNA oxidation and repair, the latter of which appeared similar in both tissues. Inhibition of phenytoin-initiated embryonic DNA oxidation by the free radical spin trapping agent alpha-phenyl-N-t-butylnitrone (41.5 mg/kg), and by acetylsalicylic acid (10 mg/kg), an inhibitor of the cyclooxygenase component of PHS, was consistent with the previously reported reduction by these inhibitors of phenytoin-initiated murine birth defects. In vitro studies using a horseradish peroxidase (0.5 mg/ml)-H2O2 (5.45 micrograms/ml) bioactivating system for drug-initiated oxidation of 2'-deoxyguanosine (3.74 mM), indicated that the potency of xenobiotic-initiated formation of 8-hydroxy-2'-deoxyguanosine for the structurally related drugs and metabolites phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, trimethadione, dimethadione, l-mephenytoin, l-nirvanol, d-nirvanol (80 microM each), or thalidomide (64 micro

  15. Correlation analysis of 1206 cases of birth defects in prenatal screening and diagnosis%1206例出生缺陷产前筛查及产前诊断的相关情况分析

    Institute of Scientific and Technical Information of China (English)

    李东海

    2012-01-01

    OBJECTIVE To know the prenatal screening and diagnosis for maternal and infant health care sector, to provide reference for establishing corresponding prevention countermeasures. METHODS Selected a total of 1 206 infants with birth defect during the years of 2008-2011 in our hospital, retrospectively analyzed the prenatal screening and prenatal diagnosis results of birth defects, comparatively analyzed the ratio in different regions without prenatal screening. RESULTS The positive cases in antenatal screening accounted for 33.4% (403/1 206), positive in prenatal diagnosis accounted for 28.8% (347/ 1 206) , without prenatal screening accounted for 9.8% (118/1 206). Interim malformations induced accounted for 25.2% (304/1 206). The first 5 causes of prenatal diagnosis of defect were as follows: neural tube defects, congenital heart disease, cleft lip, chromosomal abnormalities and strephenopodia. The first 5 causes of defect was total 295 cases, proportion of 85.1%, which were as follows; 364 cases with congenital heart disease (53.1%) , ear deformity in 79 cases (11.5%) , cleft lip in 75 cases (10.9%), cryptorchidism in 62 cases (9.1%) , polydactyly in 49 patients (7.2%). The constituent ratio that without prenatal screening (1.4%) in towns was significant lower than in countries (15.4%) (P < 0.05). CONCLUSION In order to reduce the incidence of birth defects, it should strengthen exploration on limbs and features of five sense organs in prenatal screening and diagnosis, can not only concern about the value of screening, and ignore the importance of antenatal diagnosis.%目的 为了解本地区产前筛查及产前诊断状况,给妇婴保健部门制定相应的预防对策提供参考.方法 选择2008 ~2011年期间某院分娩的出生缺陷儿,共计1206例,回顾分析出出生缺陷儿产前筛查与产前诊断结果,对照分析不同区域未进行产前筛查者构成比.结果 产前筛查阳性者占33.4% (403/1206),产前诊断阳性者占28.8

  16. Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed.

    Science.gov (United States)

    Conlin, Ava Marie S; Bukowinski, Anna T; Gumbs, Gia R

    2015-08-26

    The National Smallpox Vaccine in Pregnancy Registry (NSVIPR) actively follows women inadvertently vaccinated with smallpox vaccine during or shortly before pregnancy to evaluate their reproductive health outcomes. Approximately 65% of NSVIPR participants also inadvertently received Anthrax Vaccine Adsorbed (AVA) while pregnant, providing a ready opportunity to evaluate pregnancy and infant health outcomes among these women. AVA-exposed pregnancies were ascertained using NSVIPR and electronic healthcare data. Rates of pregnancy loss and infant health outcomes, including major birth defects, were compared between AVA-exposed and AVA-unexposed pregnancies. Analyses included AVA-exposed and AVA-unexposed pregnant women who also received smallpox vaccine 28 days prior to or during pregnancy. Rates of adverse outcomes among the AVA-exposed group were similar to or lower than expected when compared with published reference rates and the AVA-unexposed population. The findings provide reassurance of the safety of AVA when inadvertently received by a relatively young and healthy population during pregnancy.

  17. The Importance of B Ultrasound Screening in the Prevention of Birth Defects%B超筛查在预防出生缺陷中的重要性探析

    Institute of Scientific and Technical Information of China (English)

    朱亚兰

    2015-01-01

    Objective To study the use of B-summary prenatal screening to prevent birth defects and improve the quality of birth. Methods 24 cases of abnormal fetus were selected as the study object in January 2010 to January 2014 in our hospital. Statistics B Super diagnosis. Results This study examined 1 702 women who were pregnant, 24 cases of congenital fetal malformation occurs, the incidence of 1.41%. Congenital defects decreased incidence of fetal year. Including: eight cases of anencephaly children (0.47%), 6 cases of hydrocephalus (0.35%), 2 cases of spinal fracture (0.12%), 3 cases of cleft lip and palate (0.18%), 5 cases of myelomeningocele (0.29%). 24 cases of congenital malformations in the fetus, 22 cases (91.67%) by the B-ultrasound diagnosis, 2 cases (8.33%) due to the family planning service station street conditions, it could not be accurately judged by ultrasound, introduced to the district or city hospitals diagnosed. 24 cases of congenital malformation fetus gestational age of 15~30 weeks, 15~27 weeks second trimester of fetal malformation 19 cases,the incidence of 79.17%, the third trimester of fetal malformation 28~30 weeks 5 cases, the incidence of 20.83%, the second trimester a higher proportion of fetal malformation detected. Conclusion Trimester prenatal care helps detecting congenital fetal malformation, using B-screening and prevention of congenital defects in the fetus, non-invasive, simple and effective. In clinical conduct and promotion of the prenatal examination methods, professional training and capacity building of ultrasound doctors, help to improve the quality of births to minimize the rate of birth defects is delivered.%目的:研究总结出生前使用B超筛查预防出生缺陷,提高人口出生素质。方法本文采取回顾性分析法进行研究。抽取我站妇产科2010年1月~2014年1月产检筛查出的24例畸形胎儿为研究对象。统计B超确诊率。结果本次研究中共检测1702名产妇

  18. Systematic analysis of influencing factors of birth defects in China during 2001-2011%2001-2011年我国出生缺陷影响因素的系统分析

    Institute of Scientific and Technical Information of China (English)

    徐莉娟; 任培丽; 王来; 王蘅; 李春伟; 叶珊珊; 邢秀伟

    2012-01-01

    [ Objective]To investigate the influencing factors to birth defects in Chinese population during 2001-2011, and provide scientific evidence for birth defects prevention. [ Methods ] Meta-analysis was adopted to systematically evaluate 24 papers published during 2001 -2011 about the influencing factors of birth defects in China. [ Results] The pooled OR values and 95% Cl were as follows; prenatal common cold and fever 2. 00 ( 1. 46-2. 73 ) ; exposure to toxic chemical materials in pregnancy 2.02(1.51-2.71); pollution sources in apartment 1. 86(1. 26-2. 73) ; exposure to pesticides in pregnancy 1.80(1.08-2.99); taking antibiotic and other medicine in pregnancy 1. 65 (1. 37-1. 98) ; spontaneous abortion history 1. 64 (1. 13-2. 38) ; bearing malformation child history 1. 61 (1. 30-2. 01) ; paternal exposure to toxic chemical materials 1. 51 (1. 08-2. 11) ; infections of TORCH in pregnancy 1.44 (1. 10-1. 88 ); parity≥2, 1. 41 ( 1. 00-2. 01 ) ; negative life events stimulus in pregnancy 1.11(1.04-1.19). [ Conclusion] The factors influencing the incidence of birth defects are prenatal common cold and fever in pregnancy, exposure to toxic chemical materials in pregnancy, taking antibiotic and other medicine in pregnancy, negative life events stimulus in pregnancy, exposure to pesticides in pregnancy, paternal exposure to toxic chemical materials, spontaneous abortion history, bearing malformation child history, parity≥2, pollution sources in living place, infections of TORCH in pregnancy and so on.%目的 探讨我国2001-2011年间出生缺陷的影响因素,为下一步的预防提供科学依据.方法 利用Meta分析的方法系统评价2001-2011年间公开发表的有关我国出生缺陷影响因素的24篇文献.结果 出生缺陷影响因素的合并比值比(OR值)及95% CI分别为孕期感冒发热2.00(1.46 ~2.73),孕期接触有害化学物质2.02(1.51 ~2.71),居住地有污染源1.86(1.26 ~2.73),孕期接触农药史1.80(1.08 ~2.99),

  19. Cerebral palsy in eastern Denmark: declining birth prevalence but increasing numbers of unilateral cerebral palsy in birth year period 1986-1998

    DEFF Research Database (Denmark)

    Ravn, Susanne Holst; Flachs, Esben Meulengracht; Uldall, Peter

    2010-01-01

    The Cerebral Palsy Registry in eastern Denmark has been collecting cases using a uniform data sampling procedure since birth year 1979. Children are included by two child neurologists and an obstetrician. Information on pregnancy, birth, neonatal period, impairments and demographic data...... are registered. The total cerebral palsy birth prevalence has been significantly decreasing since the birth period 1983-1986 with 3.0 per 1000 live births until the period 1995-1998 with 2.1 per 1000 live births. The overall decrease was seen in preterm infants (...

  20. Birth Control Methods

    Science.gov (United States)

    ... Home A-Z Health Topics Birth control methods Birth control methods > A-Z Health Topics Birth control methods ... To receive Publications email updates Enter email Submit Birth control methods Birth control (contraception) is any method, medicine, ...

  1. Ventricular Septal Defect (For Teens)

    Science.gov (United States)

    ... upper filling chambers are the atria . In normal circulation, blood that returns from the body to the ... Causes a VSD? Ventricular septal defects occur during fetal heart development and are present at birth. During ...

  2. Epidemiology of Multiple Congenital Anomalies in Europe : A EUROCAT Population-Based Registry Study

    NARCIS (Netherlands)

    Calzolari, Elisa; Barisic, Ingeborg; Loane, Maria; Morris, Joan; Wellesley, Diana; Dolk, Helen; Addor, Marie-Claude; Arriola, Larraitz; Bianchi, Fabrizio; Neville, Amanda J.; Budd, Judith L. S.; Klungsoyr, Kari; Khoshnood, Babak; McDonnell, Bob; Nelen, Vera; Queisser-Luft, Annette; Rankin, Judith; Rissmann, Anke; Rounding, Catherine; Tucker, David; Verellen-Dumoulin, Christine; de Walle, Hermien; Garne, Ester

    2014-01-01

    BackgroundThis study describes the prevalence, associated anomalies, and demographic characteristics of cases of multiple congenital anomalies (MCA) in 19 population-based European registries (EUROCAT) covering 959,446 births in 2004 and 2010. MethodsEUROCAT implemented a computer algorithm for clas

  3. Validity of the stage of lung cancer in records of the Maastricht Cancer Registry, the Netherlands

    NARCIS (Netherlands)

    Schouten, LJ; Langendijk, JA; Jager, JJ; vandenBrandt, PA

    1997-01-01

    Information collected in a clinical study on a random sample of 99 patients with inoperable lung cancer, treated with radiotherapy, was compared to the staging information in the Maastricht cancer registry. Validity of sex (0% disagreements), date of birth (0%), histology (1% major disagreements) an

  4. Paper 3: EUROCAT data quality indicators for population-based registries of congenital anomalies

    DEFF Research Database (Denmark)

    Loane, Maria; Dolk, Helen; Garne, Ester;

    2011-01-01

    The European Surveillance of Congenital Anomalies (EUROCAT) network of population-based congenital anomaly registries is an important source of epidemiologic information on congenital anomalies in Europe covering live births, fetal deaths from 20 weeks gestation, and terminations of pregnancy for...

  5. 宁夏育龄妇女出生缺陷知识和态度及行为的影响因素调查分析%Influencing Factors for Birth Defects-related Knowledge,Attitude and Behavior among Women of Reproductive Age in ;Ningxia

    Institute of Scientific and Technical Information of China (English)

    胡继宏; 胡卫东; 靳利梅; 刘兰; 赵燚; 吴海鹰

    2014-01-01

    Background The rate of birth defects increased recently in Ningxia. The knowledge,attitude and behav-ior of birth defects among women of reproductive age influence the birth defects. Objective To provide the basis for determining the key content and ways of reproductive health education by analysing the influencing factors for birth defects-related knowl-edge,attitude and behavior among women of reproductive age in Ningxia. Methods The survey was conducted between Decem-ber 2008 and January 2009 with stratified cluster random sampling method,focusing on the rate of birth defects of all babies born from January to December 2007 in 22 counties of 5 municipalities of Ningxia,selectively examining the scores on birth defects-related knowledge,attitude and behavior among women of reproductive age and analysing the influencing factors with multivariate Logistic regression analysis. Results A total of 10 928 households were investigated,including 10 792 babies and 5 383 women of reproductive age. The rate of birth defects was 12. 87‰(n=139). The scores of knowledge,attitude and behavior were re-spectively(16. 0 ±6. 1),(11. 2 ±2. 1),(10. 7 ±2. 4). Score of knowledge was positively related to the scores of attitude(r=0. 194,P<0. 05)and behavior(r=0. 581,P<0. 05);the score of attitude was positively related to the score of behavior (r=0. 436,P<0. 05). The main influencing factors for birth defects-related knowledge were nationality,economic income and educational level(P<0. 05);the main influencing factors for birth defects-related attitude were nationality,economic in-come and educational level(P<0. 05);the main influencing factors for birth defects-related behavior were nationality,eco-nomic income,educational background and fertility circumstances(P<0. 05). Conclusion The birth defects-related knowl-edge and behavior of Hui nationality was worse than that of Han nationality in Ningxia. Economic income and educational level were the main influencing factors for birth

  6. Environmental Agents Service (EAS) Registry System of Records

    Data.gov (United States)

    Department of Veterans Affairs — The Environmental Agent Service (EAS) Registries is the information system encompassing the Ionizing Radiation Registry (IRR), the Agent Orange Registry (AOR), and...

  7. Danish National Lymphoma Registry

    Directory of Open Access Journals (Sweden)

    Arboe B

    2016-10-01

    Full Text Available Bente Arboe,1 Pär Josefsson,2 Judit Jørgensen,3 Jacob Haaber,4 Paw Jensen,5 Christian Poulsen,6 Dorthe Rønnov-Jessen,7 Robert S Pedersen,8 Per Pedersen,9 Mikael Frederiksen,10 Michael Pedersen,1 Peter de Nully Brown1 1Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2Department of Hematology, Copenhagen University Hospital, Herlev Hospital, Copenhagen, 3Department of Hematology, Aarhus University Hospital, Aarhus, 4Department of Hematology, Odense University Hospital, Odense, 5Department of Hematology, Aalborg University Hospital, Aalborg, 6Department of Hematology, Roskilde Hospital, Roskilde, 7Department of Hematology, Vejle Hospital, Vejle, 8Department of Hematology, Holstebro Hospital, Holstebro, 9Department of Hematology, Esbjerg Hospital, Esbjerg, 10Department of Hematology, Haderslev Hospital, Haderslev, Denmark Aim of database: The Danish National Lymphoma Registry (LYFO was established in order to monitor and improve the diagnostic evaluation and the quality of treatment of all lymphoma patients in Denmark. Study population: The LYFO database was established in 1982 as a seminational database including all lymphoma patients referred to the departments of hematology. The database became nationwide on January 1, 2000. Main variables: The main variables include both clinical and paraclinical variables as well as details of treatment and treatment evaluation. Up to four forms are completed for each patient: a primary registration form, a treatment form, a relapse form, and a follow-up form. Variables are used to calculate six result quality indicators (mortality 30 and 180 days after diagnosis, response to first-line treatment, and survival estimates 1, 3, and 5 years after the time of diagnosis, and three process quality indicators (time from diagnosis until the start of treatment, the presence of relevant diagnostic markers, and inclusion rate in clinical protocols. Descriptive data: Approximately 23

  8. Gastroschisis and associated defects: an international study.

    LENUS (Irish Health Repository)

    Mastroiacovo, Pierpaolo

    2007-04-01

    Our objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.

  9. Birth Plans

    Science.gov (United States)

    ... These range from how you hope to handle pain relief to fetal monitoring. Think about the environment in which you ... include in your birth plan are preferences about fetal monitoring, extra ... during labor. Pain management. This is important for most women and ...

  10. Early Pregnancy Eugenic Screening Intervention of Birth Defects%孕期优生筛查对出生缺陷干预效果的影响分析

    Institute of Scientific and Technical Information of China (English)

    邹文霓; 王丽娟; 张盈; 吴玉璘

    2012-01-01

      Objective To investigate the maternal serum pregnancy-associated plasma protein-A, alpha-fetoprotein, beta-human chorionic gonadotrophin. Combination of B-ultrasound, amniotic fluid detection means for screening and diagnosis of Jiangsu province in an area of target diseases Down's syndrome, neural tube defects. Methods This screening using time-resolved fluorescence method for the determination of PAPPA the pregnant women, serum, AFP,β-HCG level, combined with a variety of related factors, risk assessment. Results 1807 cases of second trimester pregnant women receiving prenatal screening were screened in pregnancy high-risk 21-trisomy 18-body, neural tube defects in 110 cases, the positive rate of 6.09%; and screening of high risk pregnant women the positive rate increased with increasing maternal age. 110 cases of screening-positive pregnant women, 84 cases of pregnant women receiving amniotic fluid chromosome, check out chromosomal abnormalities in two cases, 21 of them-three-body one cases;18-one cases of trisomy;B ultrasound trance administered defect in one case (one cases of spina bifida), hydrocephalus one case, two cases of congenital heart disease. Underwent induction of labor, labor induction rate of 100%. Conclusion Take the detection of maternal serum pregnancy-related protein, alpha-fetoprotein, beta-human chorionic gonadotrophin level, combined with B ultrasound, amniotic fluid detection means screening for Down syndrome, neural tube defects, birth defects, to reduce its birth rate is important.%  目的 探讨检测孕妇血清中妊娠相关蛋白A(PAPPA)、甲胎蛋白(AFP)、绒毛膜促性腺激素(β-HCG)水平,结合B超检查、羊水检测等手段,对江苏省苏北某地区目标疾病唐氏综合征、神经管缺陷进行筛查

  11. 出生缺陷患儿对陪护人心理健康影响的调查研究%Investigation on the mental health of accompanying people of birth defects

    Institute of Scientific and Technical Information of China (English)

    高立; 关晶

    2012-01-01

    目的 了解出生缺陷患儿对陪护人心理健康的影响.方法 采用生活质量综合评定量表( generic quality of life inventory-74,GQOLI-74)作为测量工具,对79名出生缺陷患儿的174名陪护人及87名正常儿童的181名陪护人的生活质量进行评价,同时结合症状自评量表(symptom check list-90,SCL-90),对其心理健康状况进行综合研究.结果 出生缺陷患儿陪护人在GQOLI-74量表的4个维度的评分均低于一般人群,差异均有统计学意义(均有P<0.05);在SCL-90量表的所有因子的得分均高于一般人群,且在躯体化、人际关系、抑郁、焦虑和精神病性5个因子的差异均有统计学意义(均有P<0.05);患儿祖(外祖)父母在SCL-90量表各因子得分普遍高于患儿父母,且在躯体化、人际关系、精神病性3个因子上的得分差异均有统计学意义(均有P<0.05).结论 出生缺陷患儿对其陪护人心理健康的影响是一个不容忽视的问题,应该引起足够的重视.%Objective To understand the birth defects' influence on the mantal health of the accompanying people. Methods 174 accompanying people of 79 patients and 181 accompanying people of 87 normal children were assessed with generic quality of life inventory-74 ( GQOLI-74 ) to detect the quality of life, symptom check list-90 ( SCL-90 ) was used to study the qualification to the mental health. Results The score of GQOLI-74 of accompanying people was obviously lower than those of the general population (all P<0. 05). The 5 factors * scores of SCL-90 of accompanying people in so-matization, interpersonal relationship, depression, anxiety and psychosis-like symptoms were higher than those of the normal group (all P<0. 05). The 3 factors' scores of SCL-90 of grandparents in somatization, interpersonal relationship and psychosis-like symptoms were higher than the parents ( all P<0.05 ). Conclusions The children with birth defects might bring the accompanying people serious

  12. Breast and Colon Cancer Family Registries

    Science.gov (United States)

    The Breast Cancer Family Registry and the Colon Cancer Family Registry were established by the National Cancer Institute as a resource for investigators to use in conducting studies on the genetics and molecular epidemiology of breast and colon cancer.

  13. March of Dimes Birth Defects Foundation

    Science.gov (United States)

    ... Join us on Facebook Follow us on Twitter Instagram: behind the scenes Our research Research grants Prematurity ... Join us on Facebook Follow us on Twitter Instagram: behind the scenes Research & Professionals Our research Research ...

  14. What Are the Types of Birth Defects?

    Science.gov (United States)

    ... Z Topics Cerebral Palsy Congenital Adrenal Hyperplasia (CAH) Down Syndrome All related topics NICHD News and Spotlights No benefit in treating mildly low thyroid function in pregnancy, NIH Network study finds NIH workshop identifies complex health problems among ...

  15. The danish multiple sclerosis registry

    DEFF Research Database (Denmark)

    Brønnum-Hansen, Henrik; Koch-Henriksen, Nils; Stenager, Egon

    2011-01-01

    Introduction: The Danish Multiple Sclerosis (MS) Registry was established in 1956. Content: The register comprises data on all Danes who had MS in 1949 or who have been diagnosed since. Data on new cases and updated information on persons with an MS diagnosis already notified are continuously...

  16. The Danish National Quality Database for Births

    Directory of Open Access Journals (Sweden)

    Andersson CB

    2016-10-01

    Full Text Available Charlotte Brix Andersson,1 Christina Flems,2 Ulrik Schiøler Kesmodel3 1Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Denmark; 2Department of Obstetrics and Gynecology, Hvidovre Hospital, Copenhagen, Denmark; 3Department of Obstetrics and Gynecology, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark Aim of the database: The aim of the Danish National Quality Database for Births (DNQDB is to measure the quality of the care provided during birth through specific indicators. Study population: The database includes all hospital births in Denmark. Main variables: Anesthesia/pain relief, continuous support for women in the delivery room, lacerations (third and fourth degree, cesarean section, postpartum hemorrhage, establishment of skin-to-skin contact between the mother and the newborn infant, severe fetal hypoxia (proportion of live-born children with neonatal hypoxia, delivery of a healthy child after an uncomplicated birth, and anesthesia in case of cesarean section. Descriptive data: Data have been collected since 2010. As of August 2015, data on women and children representing 269,597 births and 274,153 children have been collected. All data for the DNQDB is collected from the Danish Medical Birth Registry. Registration to the Danish Medical Birth Registry is mandatory for all maternity units in Denmark. During the 5 years, performance has improved in the areas covered by the process indicators and for some of the outcome indicators. Conclusion: Measuring quality of care during childbirth has inspired and enabled staff to attend to the quality of the care they provide and has led to improvements in most of the areas covered. Keywords: DNQDB, Denmark, childbirth, anesthesia

  17. Lower Birth Weight and Diet in Taiwanese Girls More than Boys Predicts Learning Impediments

    Science.gov (United States)

    Lee, Meei-Shyuan; Huang, Lin-Yuan; Chang, Yu-Hung; Huang, Susana Tzy-Ying; Yu, Hsiao-Li; Wahlqvist, Mark L.

    2012-01-01

    Possible links between lower birth weight, childhood diet, and learning in Taiwan are evaluated. The population representative Elementary School Children's Nutrition and Health Survey in Taiwan 2001-2002 and the national birth registry were used to examine school and social performance using the modified Scale for Assessing Emotional Disturbance…

  18. Study on prenatal screening of birth defect and fetal chromosomal abnormality%产前筛查先天性缺陷与胎儿染色体异常的研究

    Institute of Scientific and Technical Information of China (English)

    钟可文; 陈朝轩; 潘景良; 张应华

    2011-01-01

    Objective; To explore the junction and value of serum markers during the second trimester of pregnancy in prenatal screening of birth defect and fetal chromosomal abnormality. Methods; The serum levels of alpha fetal protein ( AFT), β - human chorionic gonadotropin ( β - HCC) and unconjugated eslriol among 2 555 pregnant women during the second trimester of pregnancy (14-22 gestation-al weeks) were detected, then risk probability was calculated combining maternal age, gestational weeks, body weight, twin pregnancy or not, diabetes mellitus or not on software; the high risk pregnant women were defined by chromosomal examination. Results; Among 2 555 pregnant women, 210 pregnant women were found with high risk of Downs syndrome, accounting for 8. 2% ; 26 pregnant women were found with high risk of trisomy 18 syndrome, accounting for 1.0% ; 29 pregnant women were found with high risk of neural tube defect, accounting for 1. 1%. Among the high risk pregnant women, 207 pregnant women received chromosomal examination of amniotic fluid cells or chromosomal examination of fetal umbilical cord blood, 12 pregnant women were found with abnormal chromosomal karyotype, the abnormal rate was 5. 8%. Conclusion; Triple markers screening during the second trimester of pregnancy is an effective method to screen fetal congenital defects, which can be used as a conventional method for prenatal screening.%目的:探讨孕中期血清标志物在产前筛查先天性缺陷与胎儿染色体异常中的作用和价值.方法:对2 555例孕中期(14 ~22周)孕妇血清AFP、β- hCG、和uE3三项指标进行检测,并结合孕妇年龄、孕周、体重、是否双胎、有无糖尿病等,采用仪器配套软件计算风险概率,对高风险孕妇进行染色体检查确认.结果:2 555例孕妇中筛查出唐氏综合征高风险210例,占8.2%,18-三体高风险26例,占1.0%,NTD高风险29例,占1.1%,高风险孕妇中有207例自愿进行了羊水细胞染色体检查或胎

  19. Risk factors for perinatal mortality in Murmansk County, Russia: a registry-based study

    Science.gov (United States)

    Usynina, Anna A.; Grjibovski, Andrej M.; Krettek, Alexandra; Odland, Jon Øyvind; Kudryavtsev, Alexander V.; Anda, Erik Eik

    2017-01-01

    ABSTRACT Background: Factors contributing to perinatal mortality (PM) in Northwest Russia remain unclear. This study investigated possible associations between selected maternal and fetal characteristics and PM based on data from the population-based Murmansk County Birth Registry. Objective: This study investigated possible associations between selected maternal and fetal characteristics and PM based on data from the population-based Murmansk County Birth Registry. Methods: The study population consisted of all live- and stillbirths registered in the Murmansk County Birth Registry during 2006–2011 (n = 52,806). We excluded multiple births, births prior to 22 and after 45 completed weeks of gestation, infants with congenital malformations, and births with missing information regarding gestational age (a total of n = 3,666) and/or the studied characteristics (n = 2,356). Possible associations between maternal socio-demographic and lifestyle characteristics, maternal pre-pregnancy characteristics, pregnancy characteristics, and PM were studied by multivariable logistic regression. Crude and adjusted odds ratios with 95% confidence intervals were calculated. Results: Of the 49,140 births eligible for prevalence analysis, 338 were identified as perinatal deaths (6.9 per 1,000 births). After adjustment for other factors, maternal low education level, prior preterm delivery, spontaneous or induced abortions, antepartum hemorrhage, antenatally detected or suspected fetal growth retardation, and alcohol abuse during pregnancy all significantly increased the risk of PM. We observed a higher risk of PM in unmarried women, as well as overweight or obese mothers. Maternal underweight reduced the risk of PM. Conclusions: Our results suggest that both social and medical factors are important correlates of perinatal mortality in Northwest Russia. PMID:28156197

  20. Some Considerations on the Adoption Registration in the Civil Registry

    Directory of Open Access Journals (Sweden)

    Gabriela LUPŞAN

    2014-12-01

    Full Text Available Filiation is, in a broad sense, an identity element, dependent or not on the biological relationships, that represents, in some situations, either a condition for the existence of a right (e.g. the right to inheritance or for example to conclude a legal act (e.g. marriage. The proof of filiation is the birth certificate drawn up in civil registry or on the material basis of birth, or on the basis of the adoption judgment. In this paper, we aimed at analyzing the final part of the adoption procedure, the subsequent stage for becoming final the adoption judgment, which sets face to face the adopting person or family and the administrative authority, obliged to execute the judge's decision, i.e. to create a filiation relation between the adopted on the one hand and the adoptive parent or parents.

  1. 青龙满族自治县育龄妇女预防出生缺陷知识知晓情况现状及影响因素分析%Analysis of status and influence factors of women of childbearing age be-ing aware of birth defects knowledge in Qinglong Manchu Autonomous County

    Institute of Scientific and Technical Information of China (English)

    王民

    2015-01-01

    目的 了解青龙满族自治县育龄妇女预防出生缺陷知识知晓情况现状及影响因素,以便有针对性地开展出生缺陷预防工作,降低出生缺陷发生率. 方法 随机抽取青龙满族自治县2014年1月~2015年7月符合生育政策、计划怀孕并参加免费孕前优生健康检查的1200名育龄妇女,使用自行设计的统一调查问卷,进行预防出生缺陷知识知晓情况自填式问卷调查. 结果 育龄妇女获取预防出生缺陷知识的途径形式单一,依次为书籍杂志、医院、网络等,预防出生缺陷知识的总知晓率仅为68%;影响育龄妇女预防出生缺陷知识知晓情况的因素为年龄、文化水平、职业、经济条件等.其中20~32岁年龄段的人群高于33~39岁;大专及以上文化程度的人群高于其他文化长度的人群; 有固定工作的人群高于无固定工作的人群; 经济收入较高的人群高于经济收入较低的人群(P<0.01). 结论 青龙满族自治县育龄妇女预防出生缺陷知识知晓率较低,应引起有关部门重视,应根据影响育龄妇女预防出生缺陷知识知晓情况的因素,认真开展多种渠道的健康教育宣传,提高育龄妇女预防出生缺陷知识的知晓率,有效降低出生缺陷发生的风险.%Objective To know the status and influence factors of women of childbearing age being aware of birth de-fect knowledge in Qinglong Manchu Autonomous County to carry out targetedly the prevention work of birth defect and reduce the incidence rate of birth defect. Methods 1200 women of childbearing age who had met the requirement for pregnancy and were planning to have a baby and had participated in the free pre-pregnancy health examination for eu-genics from January 2014 to July 2015 were randomly selected.Self-designed and self-administrated unified question-naire was adopted to investigate the status of awareness of birth defect prevention knowledge. Results Women of child-bearing age got to

  2. A renal registry for Africa: first steps.

    Science.gov (United States)

    Davids, M Razeen; Eastwood, John B; Selwood, Neville H; Arogundade, Fatiu A; Ashuntantang, Gloria; Benghanem Gharbi, Mohammed; Jarraya, Faiçal; MacPhee, Iain A M; McCulloch, Mignon; Plange-Rhule, Jacob; Swanepoel, Charles R; Adu, Dwomoa

    2016-02-01

    There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African Association of Nephrology (AFRAN) and the African Paediatric Nephrology Association (AFPNA) recognize the importance of good registry data and plan to establish an African Renal Registry. This article reviews the elements needed for a successful renal registry and gives an overview of renal registries in developed and developing countries, with the emphasis on Africa. It then discusses the proposed African Renal Registry and the first steps towards its implementation. A registry requires a clear purpose, and agreement on inclusion and exclusion criteria, the dataset and the data dictionary. Ethical issues, data ownership and access, the dissemination of findings and funding must all be considered. Well-documented processes should guide data collection and ensure data quality. The ERA-EDTA Registry is the world's oldest renal registry. In Africa, registry data have been published mainly by North African countries, starting with Egypt and Tunisia in 1975. However, in recent years no African country has regularly reported national registry data. A shared renal registry would provide participating countries with a reliable technology platform and a common data dictionary to facilitate joint analyses and comparisons. In March 2015, AFRAN organized a registry workshop for African nephrologists and then took the decision to establish, for the first time, an African Renal Registry. In conclusion, African nephrologists have decided to establish a continental renal registry. This initiative could make a substantial impact on the practice of nephrology and the provision of services for adults and children with ESRD in many African countries.

  3. The investigate and research on the common birth defect children to the economic burden of the family in the rural area of Jining City%济宁农村地区常见出生缺陷患儿致家庭经济负担的调查研究

    Institute of Scientific and Technical Information of China (English)

    关晶; 高立

    2013-01-01

    目的 了解济宁农村地区常见出生缺陷患儿致家庭经济负担的情况.方法 对济宁农村地区4种常见出生缺陷共177名患儿的家庭进行调查,通过调查出生缺陷种类及治疗费用情况,结合生活质量综合问卷(GQOLI)调查,对农村地区出生缺陷患儿致家庭经济负担的情况进行综合评定.结果 177个家庭每年用于对患儿的各种医疗支出均超过家庭收入的90%以上,部分患儿当年医疗支出甚至超过了当年家庭总收入;出生缺陷患儿家庭成员在GQOLI量表的总分及物质生活维度、躯体健康维度、心理健康维度、社会功能维度4个方面得分均低于普通农村人口,且在物质生活维度方面差异最大,差异均有统计学意义(P<0.05).结论 各种出生缺陷在严重影响患者自身生命质量的同时,给农村家庭造成的负担不客忽视.%Objective:To understand the common birth defect children to the economic burden of the family in the rural area of Jining city.Methods:390 family members with 177 birth defect children were investigated with the kind of birth defect,family annual total income and disease treatment of expenditure,tested with GQOLI to relevant the qualification to the mental healthy and quality of life.Results:All families for birth defect children with medical expenses are more than 90% of the household total income,many birth defect children with medical spending even more than the total family income.The 4 scale of GQOLI of family members with birth defect children were all belower than the general rural population,especially in material life dimension,the difference has statistically significant (P < 0.01).Conslusion:All kinds of birth defect could not only heavily influenced the quality of the patients,but also caused great burden to the family in the rural rare.

  4. Reducing selection bias in case-control studies from rare disease registries

    Directory of Open Access Journals (Sweden)

    Mistry Pramod K

    2011-09-01

    Full Text Available Abstract Background In clinical research of rare diseases, where small patient numbers and disease heterogeneity limit study design options, registries are a valuable resource for demographic and outcome information. However, in contrast to prospective, randomized clinical trials, the observational design of registries is prone to introduce selection bias and negatively impact the validity of data analyses. The objective of the study was to demonstrate the utility of case-control matching and the risk-set method in order to control bias in data from a rare disease registry. Data from the International Collaborative Gaucher Group (ICGG Gaucher Registry were used as an example. Methods A case-control matching analysis using the risk-set method was conducted to identify two groups of patients with type 1 Gaucher disease in the ICGG Gaucher Registry: patients with avascular osteonecrosis (AVN and those without AVN. The frequency distributions of gender, decade of birth, treatment status, and splenectomy status were presented for cases and controls before and after matching. Odds ratios (and 95% confidence intervals were calculated for each variable before and after matching. Results The application of case-control matching methodology results in cohorts of cases (i.e., patients with AVN and controls (i.e., patients without AVN who have comparable distributions for four common parameters used in subject selection: gender, year of birth (age, treatment status, and splenectomy status. Matching resulted in odds ratios of approximately 1.00, indicating no bias. Conclusions We demonstrated bias in case-control selection in subjects from a prototype rare disease registry and used case-control matching to minimize this bias. Therefore, this approach appears useful to study cohorts of heterogeneous patients in rare disease registries.

  5. Paternity acknowledgment in 2 million birth records from Michigan.

    Directory of Open Access Journals (Sweden)

    Douglas Almond

    Full Text Available Out-of-wedlock childbearing is more common in the U.S. than in other countries and becoming more so. A growing share of such non-marital births identify the father, which can create a legal entitlement to child support. Relatively little is known about individual determinants of the decision to establish paternity, in part because of data limitations. In this paper, we evaluate all birth records in Michigan from 1993 to 2006, which have been merged to the paternity registry. In 2006, 30,231 Michigan children, almost one quarter of all Michigan births, were born to unmarried mothers and had paternity acknowledged. We find that births with paternity acknowledged have worse outcomes along various health and socio-economic dimensions relative to births to married parents, but better outcomes relative to births to unmarried parents without paternity acknowledgement. Furthermore, unmarried men who father sons are significantly more likely to acknowledge paternity than fathers of daughters.

  6. Forensic Analysis of Windows Registry Against Intrusion

    Directory of Open Access Journals (Sweden)

    Haoyang Xie

    2012-03-01

    Full Text Available Windows Registry forensics is an important branch of computer and network forensics. Windows Registry is often considered as the heart of Windows Operating Systems because it contains allof the configuration setting of specific users, groups, hardware, software, and networks. Therefore, Windows Registry can be viewed as a gold mine of forensic evidences which could be used in courts. This paper introduces the basics of Windows Registry, describes its structure and its keys and subkeys thathave forensic values. This paper also discusses how the Windows Registry forensic keys can be applied in intrusion detection.

  7. New registry: National Cancer Patient Registry--Colorectal Cancer.

    Science.gov (United States)

    Wendy, L; Radzi, M

    2008-09-01

    Colorectal cancer is emerging as one of the commonest cancers in Malaysia. Data on colorectal cancer from the National Cancer Registry is very limited. Comprehensive information on all aspects of colorectal cancer, including demographic details, pathology and treatment outcome are needed as the management of colorectal cancer has evolved rapidly over the years involving several disciplines including gastroenterology, surgery, radiology, pathology and oncology. This registry will be an important source of information that can help the development of guidelines to improve colorectal cancer care relevant to this country. The database will initially recruit all colorectal cancer cases from eight hospitals. The data will be stored on a customized web-based case report form. The database has begun collecting data from 1 October 2007 and will report on its first year findings at the end of 2008.

  8. 降低出生缺陷关键技术及干预措施的研究%Study on key techniques and intervention in reducing birth defects

    Institute of Scientific and Technical Information of China (English)

    朱宝生; 林克萍; 陈红; 李苏云; 苏洁; 卢晓红; 贺静; 朱姝; 焦存仙; 章锦曼; 唐新华; 陶滢

    2011-01-01

    低风险孕妇的妊娠结局,未发现活产儿中有上述目标疾病的患儿。血清学筛查对DS的检出率为84%( 27/32),假阳性率为6.153%( 1702/27 660)。结论孕前及孕早期补充叶酸可降低出生缺陷风险,但育龄期妇女主动补充叶酸者仅占1/3;血清学筛查可高效检出DS、ES和NTD;遗传咨询对诊断高风险和遗传病家族史的人群至关重要;以血清学筛查和产前诊断为关键技术,与常规产前检查相结合,可以降低严重出生缺陷的发生率,应成为我国的新型围产保健策略。%ObjectiveTo investigate key techniques and intervention in reducing birth defects. Method Down's syndrome (DS), trisomy-18 (Edwards syndrome, ES), neural tube defects (NTD), Duchenne muscular dystrophy (DMD), spinal muscular atrophy (SMA), thalassemia, and glucose-6-phosphate dehydrogenase deficiency (G6PD) were chosen as target disease. From Jan. 2007 to Dec. 2009, the condition of intake folie acid were investigated in 5004 pregnant women in Panlong District and Wuhua District of Kunming City. All of the 27 660 pregnant women undergoing prenatal examination were enrolled into the study from the First People's Hospital of Yunnan Province, the Second People's Hospital of Yunnan Province, the First People's Hospital of Qujing City, the Second People's of Qujing City, Qujing Women and Children's Hospital, People's Hospital of Lincang City, Kunming Maria Women's Hospital, Maternal and Infant's Care Unit of Panlong District of Kunming City, Maternal and Infant's Hospital of Dali City. The screening was performed on serum of those pregnant women at 8 -20 +6 gestational weeks. Prenatal cytogenetic analysis and fetal ultrasonogrspy were performed on the high risk or indicated women after genetic counseling. DNA analysis was administered on those women with family or childbearing history of DMD,SMA, thalassemia, or G6PD. Outcome of pregnancy was followed up to evaluate the effect of

  9. The origin of congenital heart defects and the epigenetic programming of the healthy child

    NARCIS (Netherlands)

    S.A. Obermann-Borst (Sylvia)

    2013-01-01

    textabstractBirth defects are a global burden affecting 7% of births worldwide. Congenital heart defects (CHD) are the most common congenital malformation with approximately 1 million children born each year. It is not only the most frequent group of birth defects in human, but also the leading caus

  10. Birth characteristics and Wilms tumors in children in the Nordic countries

    DEFF Research Database (Denmark)

    Schüz, Joachim; Schmidt, Lisbeth Samsø; Kogner, Per

    2011-01-01

    -for-gestational age girls also had a higher risk (2.48, 1.51-4.05), whereas no effect was seen for boys (1.12, 0.60-2.07). An association was seen with Apgar score at 5 min parental age and birth order. In our large-scale, registry......Little is known about causes of Wilms tumor. Because of the young age at diagnosis, several studies have looked at various birth characteristics. We conducted a registry-based case-control study involving 690 cases of Wilms tumor aged 0-14 years, occurring in Denmark, Finland, Norway or Sweden...... during 1985-2006, individually matched to five controls drawn randomly from the Nordic childhood population. Information on birth characteristics was obtained from the population-based medical birth registries. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic...

  11. On the Cooperation of Independent Registries

    CERN Document Server

    Miraz, Matteo

    2010-01-01

    Registries play a key role in service-oriented applications. Originally, they were neutral players between service providers and clients. The UDDI Business Registry (UBR) was meant to foster these concepts and provide a common reference for companies interested in Web services. The more Web services were used, the more companies started create their own local registries: more efficient discovery processes, better control over the quality of published information, and also more sophisticated publication policies motivated the creation of private repositories. The number and heterogeneity of the different registries - besides the decision to close the UBR are pushing for new and sophisticated means to make different registries cooperate. This paper proposes DIRE (DIstributed REgistry), a novel approach based on a publish and subscribe (P/S) infrastructure to federate different heterogeneous registries and make them exchange information about published services. The paper discusses the main motivations for the P...

  12. Client interfaces to the Virtual Observatory Registry

    Science.gov (United States)

    Demleitner, M.; Harrison, P.; Taylor, M.; Normand, J.

    2015-04-01

    The Virtual Observatory Registry is a distributed directory of information systems and other resources relevant to astronomy. To make it useful, facilities to query that directory must be provided to humans and machines alike. This article reviews the development and status of such facilities, also considering the lessons learnt from about a decade of experience with Registry interfaces. After a brief outline of the history of the standards development, it describes the use of Registry interfaces in some popular clients as well as dedicated UIs for interrogating the Registry. It continues with a thorough discussion of the design of the two most recent Registry interface standards, RegTAP on the one hand and a full-text-based interface on the other hand. The article finally lays out some of the less obvious conventions that emerged in the interaction between providers of registry records and Registry users as well as remaining challenges and current developments.

  13. Client Interfaces to the Virtual Observatory Registry

    CERN Document Server

    Demleitner, Markus; Taylor, Mark; Normand, Jonathan

    2015-01-01

    The Virtual Observatory Registry is a distributed directory of information systems and other resources relevant to astronomy. To make it useful, facilities to query that directory must be provided to humans and machines alike. This article reviews the development and status of such facilities, also considering the lessons learnt from about a decade of experience with Registry interfaces. After a brief outline of the history of the standards development, it describes the use of Registry interfaces in some popular clients as well as dedicated UIs for interrogating the Registry. It continues with a thorough discussion of the design of the two most recent Registry interface standards, RegTAP on the one hand and a full-text-based interface on the other hand. The article finally lays out some of the less obvious conventions that emerged in the interaction between providers of registry records and Registry users as well as remaining challenges and current developments.

  14. 孕妇红细胞叶酸水平与胎儿出生缺陷发病关系的研究%Red cell folate concentration in relation to birth defects

    Institute of Scientific and Technical Information of China (English)

    谭春英; 王燕; 楚严; 毛学群; 张邵勤

    2011-01-01

    Objective; Make know the relationship between the red cell folate concentration and the birth defeces. Methods; Subjects were women in their first trimester of pregnancy. The 1504 gravidas were invided into three groups; A group; have no folate supplement; B group; have folate supplement after pregnant; C group; have folate supplement before pregnant. A face - to - face questionnaire was administrated to each woman. 2 ml venous blood was drawn and red cell folat concentrations were determined and follow - up the fetus. Then analysis contrast amongst three groups. Results; (J) In A group the mean red cell folate concentration was 348. 88 ±93. 34nmol/L, B was 577.64 ±216. 14 nmol/L, C was 932.09 ±200. 25 nmol/L. There was significant difference among the three groups ( P<0.01). (2) In A group there were 35 fetus who were congenital defects (including congenital heart defects 9, chromosome disorder 3, orofacial clefts 5, urogenital system anomalies 10, NTDs 3, limb anomalies 2, alimentary system 1 and others were 3. In B group there were 8, including chromosome disorder 2, urogenital system anomalies 2, limb anomalies 2, orofacial clefts 1, congenital heart defects 1. In C group there were 7, including Down's syndrome 1, limb anomalies 2, urogenital system anomalies 2, orofacial clefts 1, pulmocystodeoma 1. Conclusion Periconceptional intake of folic acid can increase the red cell folate concentration and can low the morbility of congenital defects, especially in chromosome disorder and congenital heart defects.%目的 探讨孕妇红细胞叶酸水平与胎儿出生缺陷的发病关系.方法 选择2007年9月至2008年12月在北京市海淀区妇幼保健院行常规产检的孕妇1504例作为研究对象,初检孕周12~15周,根据口服叶酸的时间不同分为三组:A组:孕前、孕期从未口服叶酸者210例;B组:孕后口服叶酸组者480例;C组:孕前口服叶酸者801例.在孕妇初诊时抽取外周血检测红细胞叶酸水平,比较三

  15. A cohort study on the relationship between serum folic acid of pregnant women during the first trimester of pregnancy and onset of fetal birth defects%妊早期妇女血清叶酸水平与胎儿出生缺陷发病关系的队列研究

    Institute of Scientific and Technical Information of China (English)

    王珊; 潘新娟; 余增丽

    2012-01-01

    Objective: To explore the relationship between serum folic acid of pregnant women and onset of fetal birth defects. Methods: The pregnant women who received prenatal examination and met the inclusion criteria in the hospital from April 2007 to April 2010 were selected as respondents, then they were divided into group A (never taking folic acid before and during pregnancy) , group B (taking folic acid after pregnancy) , and group C ( taking folic acid before and after pregnancy) , the serum levels of folic acid in the three groups were compared; all the pregnant women were followed up till six months after birth, the pregnancy outcome was surveyed, and the incideuees of birth defects in the three groups were compared. Results: The serum level of folic acid in group A was significantly lower than those in group B and group C, the mean serum level of folic acid in group C was higher than that in group B ( P < 0. 05 ) . The incidence of fetal birth defects in group A was significantly higher than those in group B and group C ( P <0. 05) . Compared with pregnant women taking folic acid regularly during pregnancy, the relative risk ratio of fetuses with birth defects in the pregnant women not taking folic acid regularly was 3. 48 (2. 02/0. 58) , increasing by 2. 48 times. Conclusion: The folic acid level of pregnant women during the first trimester of pregnancy is related to birth defects, taking folic acid during pregnancy can reduce the risk of birth defects.%目的:探讨孕妇血清叶酸水平与胎儿出生缺陷发病的关系.方法:选择2007年4月~ 2010年4月在开封市妇产医院进行产检的、符合纳入标准的孕妇为调查对象,按其服用叶酸的情况分为A组(孕前、孕期从未口服叶酸)、B组(孕后口服叶酸)、C组(孕前、孕后均口服叶酸),比较三组血清叶酸水平;对其进行随访至胎儿出生6个月,调查出生结局,比较三组出生缺陷发生情况.结果:A组的血清叶酸平均水平明显低于B

  16. The Danish Lung Cancer Registry

    DEFF Research Database (Denmark)

    Jakobsen, Erik; Rasmussen, Torben Riis

    2016-01-01

    AIM OF DATABASE: The Danish Lung Cancer Registry (DLCR) was established by the Danish Lung Cancer Group. The primary and first goal of the DLCR was to improve survival and the overall clinical management of Danish lung cancer patients. STUDY POPULATION: All Danish primary lung cancer patients since...... 2000 are included into the registry and the database today contains information on more than 50,000 cases of lung cancer. MAIN VARIABLES: The database contains information on patient characteristics such as age, sex, diagnostic procedures, histology, tumor stage, lung function, performance...... the results are commented for local, regional, and national audits. Indicator results are supported by descriptive reports with details on diagnostics and treatment. CONCLUSION: DLCR has since its creation been used to improve the quality of treatment of lung cancer in Denmark and it is increasingly used...

  17. The Danish Shoulder Arthroplasty Registry

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe; Jakobsen, John; Brorson, Stig

    2012-01-01

    The Danish Shoulder Arthroplasty Registry (DSR) was established in 2004. Data are reported electronically by the surgeons. Patient-reported outcome is collected 10-14 months postoperatively using the Western Ontario osteoarthritis of the shoulder index (WOOS). 2,137 primary shoulder arthroplasties......% reverse shoulder arthroplasties, and 3% total arthroplasties. Median WOOS was 59% (IQR: 37-82). 5% had been revised by the end of June 2010. The most frequent indications for revision were dislocation or glenoid attrition....

  18. The Danish National Prescription Registry

    DEFF Research Database (Denmark)

    Kildemoes, Helle Wallach; Toft Sørensen, Henrik; Hallas, Jesper

    2011-01-01

    Introduction: Individual-level data on all prescription drugs sold in Danish community pharmacies has since 1994 been recorded in the Register of Medicinal Products Statistics of the Danish Medicines Agency. Content: The register subset, termed the Danish National Prescription Registry (DNPR...... on the dispensed drug. Conclusion: The possibility of linkage with many other nationwide individual-level data sources renders the DNPR a very powerful pharmacoepidemiological tool...

  19. The Danish Heart Failure Registry

    Directory of Open Access Journals (Sweden)

    Schjødt I

    2016-10-01

    Full Text Available Inge Schjødt,1 Anne Nakano,2,3 Kenneth Egstrup,4 Charlotte Cerqueira5 1Department of Cardiology, 2Department of Clinical Epidemiology, Aarhus University Hospital, 3Registry Support Centre of Clinical Quality and Health Informatics (West, Aarhus, 4Department of Cardiology, Odense University Hospital, Svendborg Hospital, Svendborg, 5Registry Support Centre of Epidemiology and Biostatistics (East, Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark Aim of database: The aim of the Danish Heart Failure Registry (DHFR is to monitor and improve the care of patients with incident heart failure (HF in Denmark. Study population: The DHFR includes inpatients and outpatients ($18 years with incident HF. Reporting to the DHFR is mandatory for the Danish hospital departments treating patients with incident HF. Final decision to register a patient in the DHFR is made by a cardiologist to ensure the validity of the diagnosis. Approximately 42,400 patients with incident HF were registered in the DHFR in July 2015. Main variables and descriptive data: The main variables recorded in the DHFR are related to the indicators for quality of care in patients with incident HF: performance of echocardiography, functional capacity (New York Heart Association functional classification, pharmacological therapy (angiotensin converting enzyme/angiotensin II antagonist inhibitors, beta-blockers, and mineralocorticoid receptor antagonist, nonpharmacological therapy (physical training, patient education, 4-week readmission rate, and 1-year mortality. Furthermore, basic patient characteristics and prognostic factors (eg, smoking and alcohol are recorded. At the annual national audit in the DHFR, the indicators and standards for good clinical quality of care for patients with HF are discussed, and recommendations are reported back to clinicians to promote quality improvement initiatives. Furthermore, results and recommendations are communicated

  20. Birth cohorts

    DEFF Research Database (Denmark)

    Andersen, Anne-Marie Nybo; Madsen, Mia

    2009-01-01

    ; provides practical guidance on how to set-up and maintain birth cohorts for completing family-based studies in life course epidemiology; describes how to undertake appropriate statistical analyses of family-based studies and correctly interpret results from these analyses; and provides examples...... that illustrate the ways in which family-based studies can enhance our understanding of life course epidemiology. In addition, there is discussion of difficulties specific to setting up such studies in low- and middle-income countries, and issues relating to proxy informants, where parents provide information...... on children and vice versa, or siblings provide information about each other. Examples of how family-based studies have been used in understanding the life course epidemiology of cardiovascular disease, mental health, and reproductive health illustrate the applicability of the research to these areas...

  1. Evaluation of institutional cancer registries in Colombia.

    Science.gov (United States)

    Cuervo, L G; Roca, S; Rodríguez, M N; Stein, J; Izquierdo, J; Trujillo, A; Mora, M

    1999-09-01

    The four primary objectives of this descriptive study were to: 1) design a quality-measurement instrument for institutional cancer registries (ICRs), 2) evaluate the existing ICRs in Colombia with the designed instrument, 3) categorize the different registries according to their quality and prioritize efforts that will efficiently promote better registries with the limited resources available, and 4) determine the institution with the greatest likelihood of successfully establishing Colombia's second population-based cancer registry. In 1990 the National Cancer Institute of Colombia developed 13 institution-based cancer registries in different Colombian cities in order to promote the collection of data from a large group of cancer diagnostic and treatment centers. During the first half of 1997, this evaluation reviewed 12 registries; one of the original 13 no longer existed. All of the Colombian institutions (hospitals) that maintain institution-based cancer registries were included in the study. At each institution, a brief survey was administered to the hospital director, the registry coordinator, and the registrar (data manager). Researchers investigated the institutions by looking at six domains that are in standard use internationally. Within each domain, questions were developed and selected through the Delphi method. Each domain and each question were assigned weights through a consensus process. In most cases, two interviewers went to each site to collect the information. The university hospitals in Cali, Pereira, and Medellín had substantially higher scores, reflecting a good level of performance. Four of the 12 institutions had almost no cancer registry work going on. Five of the 12 hospital directors considered that the information provided by the cancer registries influenced their administrative decisions. Three of the registries had patient survival data. Four of the institutions allocated specific resources to operate their cancer registries; in the

  2. 广东省深圳市龙岗区孕期妇女出生缺陷相关知信行调查%Survey on knowledge, attitudes and practices about birth defects among pregnant women in Longgang District of Shenzhen, Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    张绍强; 廖瑞容; 张玲; 陈文英; 夏洪波

    2012-01-01

    Objective To determine knowledge, attitude and practice about birth defects among pregnant women, and provide reasonable suggestions to improve perinatal health services and health education. Methods Stratified. Random sampling method was used to select 86 of pregnant women from three streets of Longgang District, Shenzhen City as participants in this study. Results There were 91. 86% of pregnant women had heard of birth defect before pregnancy. 80. 77% of them women said they supported the policy of distributing folic acid free by government 50% of respondents conducted premarital medical examination. In higher education level group, the participation rate in premarital medical examination of couples was significantly higher than that with low literacy. Moreover, pregnant women with higher literacy would pay more attention to prenatal care, prevention of birth defects and folic acid knowledge. The pregnant women with higher per capita monthly income of family would have higher degree of attention to you should get rid of contacting with pesticides/paint and reduce the opportunities of touching cats and dogs. The sources of knowledge about prevention birth defects before pregnancy were mainly from doctors and communication materials, with the proportion of 30.23% and 29.07% , respectively. Conclusion The findings showed that the level of general knowledge about birth defect and folic acid was relatively high among pregnant women in Longgang District. Literacy and per capita monthly income of family are influencing factors on knowledge about birth defects among pregnant women.%目的 了解广东省深圳市龙岗区孕期妇女对预防出生缺陷的知信行情况,为进一步完善围产期保健服务及健康教育工作提供合理化建议.方法 采用分层随机抽样方法,抽取86名孕期妇女进行面对面问卷调查.结果 91.86%的孕期妇女在怀孕前听说过出生缺陷,80.77%的孕期妇女对政府免费发放

  3. 杭州市余杭区人群基础出生缺陷普查及高危因素研究%Prevalence of birth defects and related risk factors among children age 0 - 3 years old in Yuhang District

    Institute of Scientific and Technical Information of China (English)

    王撬撬; 周任婧; 陈琴芳; 刘小芹; 袁伟; 王波

    2012-01-01

    Objective: To know about the prevalence of birth defects in Yuhang District of Hangzhou City and to explore the risk factors related to birth defects. Methods; A total of 21 713 children aged 0-3 years old were investigated in Yuhang District. A case - control study was used to determine potential risk factors. Results: A total of 365 children with birth defects were found. Low income, poor health during pregnancy, strenuous work for women three months before pregnancy and taking medicine during pregnancy could increase the risk of birth defects. Moreover, experience of second - smoking exposure for pregnant women, spouses'poor health status and elder age (above 35 years old) also contributed to birth defects. Conclusion; It is necessary to prevent birth defects by improving the knowledge about health care among pregnant women and providing primary prevention strategy.%目的:获得余杭区出生缺陷基本信息,寻找出生缺陷高危因素,为出生缺陷病因学研究及防治措施提供可靠依据.方法:对2007年6月1日~2010年5月31日分娩(孕周≥28周),在余杭区进行出生申报的21 713名0~3岁婴幼儿进行出生缺陷信息收集.根据基线调查结果,采用1:2病例对照研究方法,收集出生缺陷组及对照组孕母人口学特征、孕前及妊娠期精神情况、药物暴露史等信息.结果:共筛查出生缺陷儿365名.出生缺陷高危因素分析发现,家庭收入低、母亲健康状况差、孕前3个月工作强度高、精神压力大和妊娠期间服用药物等因素是余杭地区出生缺陷发生的高危因素.此外,孕妇妊娠期存在被动吸烟情况、配偶健康状况差及生育年龄>35岁也会增加出生缺陷发生危险.结论:进一步加强优生优育宣教,提高育龄妇女自我保健意识,深化出生缺陷一级预防干预策略,以降低出生缺陷发生风险.

  4. [Current registry studies of acute ischemic stroke].

    Science.gov (United States)

    Veltkamp, R; Jüttler, E; Pfefferkorn, T; Purrucker, J; Ringleb, P

    2012-10-01

    Study registries offer the opportunity to evaluate the effects of new therapies or to observe the consequences of new treatments in clinical practice. The SITS-MOST registry confirmed the validity of findings from randomized trials on intravenous thrombolysis concerning safety and efficacy in the clinical routine. Current study registries concerning new interventional thrombectomy techniques suggest a high recanalization rate; however, the clinical benefit can only be evaluated in randomized, controlled trials. Similarly, the experiences of the BASICS registry on basilar artery occlusion have led to the initiation of a controlled trial. The benefit of hemicraniectomy in malignant middle cerebral artery infarction has been demonstrated by the pooled analysis of three randomized trials. Numerous relevant aspects are currently documented in the DESTINY-R registry. Finally, the recently started RASUNOA registry examines diagnostic and therapeutic aspects of ischemic and hemorrhagic stroke occurring during therapy with new oral anticoagulants.

  5. ADVERSE PREGNANCY OUTCOMES IDENTIFIED BY THE POPULATION-BASED BIRTH DEFECTS SURVEILLANCE SYSTEMS IN MIANZHU AND EMEI OF SICHUAN PROVINCE%四川省绵竹县和峨眉山市出生缺陷人群监测的不良妊娠结局发生情况

    Institute of Scientific and Technical Information of China (English)

    牟祎; 代礼; 朱军; 梁娟; 王艳萍; 毛萌; 刘敬涛; 代蜀平; 李英

    2011-01-01

    [目的]了解四川省绵竹县和峨眉山市出生缺陷及其他不良妊娠结局的发生情况.[方法]2006年10月~2009年9月期间,采用以人群为基础的出生缺陷监测方法收集数据,调查监测区域内所有孕满28周的新生儿并随访至生后42 d.分析出生缺陷、围产儿死亡、婴儿死亡、低出生体重的发生情况以及出生缺陷患儿的监测期转归.[结果]绵竹县、峨眉山市的出生缺陷发生率分别为120.43/万和104.85/万.绵竹县出生缺陷患儿中死胎死产比例和监测期内死亡比例为15.38%和4.40%;峨眉山市的这两个比例为3.49%和13.95%.绵竹县出生人口中的死胎死产率、围产儿死亡率、监测期婴儿死亡率、低出生体重率分别为4.37‰、5.82‰、1.99‰和20.78‰;峨眉山市分别为1.95‰,5.85%,16.00‰和30.60‰.[结论]出生缺陷等不良妊娠结局在绵竹县和峨眉山市的分布不同,提示针对性的妇幼保健干预应注意影响因素的差异;研究结果也表明现有人群监测系统在评估出生人口素质方面起着重要作用.%[Objective] To investigate the occurrence of birth defects and other adverse pregnancy outcomes in Mianzhu county and Emei city. [Methods] During October 2007 to September 2009, population-based birth defects surveillance was adopted to collect data in Mianzhu county and Emei city, Sichuan, China. All births (aged 28 gestation weeks or more) born to mothers who lived in monitored areas were recruited, and followed up within 42 days by health professionals according to u-niform guide. The major birth defects, perinatal deaths, infant mortalities and low birth weights among these two populations were analyzed. The outcome of the newborns with birth defects was also assessed. [Results] The prevalence of gross birth defects in Mianzhu and Emei was 120.43/10 000 and 104.85/10 000, respectively. The stillbirth, infant death within 42 days accounted for 15.38%, 4.40 % of birth defect cases in

  6. Validity of preeclampsia-related diagnoses recorded in a national hospital registry and in a postpartum interview of the women

    DEFF Research Database (Denmark)

    Klemmensen, Ase K; Olsen, Sjurdur F; Osterdal, Marie Louise;

    2007-01-01

    In a population-based sample, the authors examined the validity of preeclampsia and related diagnoses recorded in a mandatory Danish national hospital discharge registry and in a standardized telephone interview of women who gave birth between 1998 and 2002. Using a "gold standard" for preeclamps...

  7. Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the Dutch and Danish biliary atresia registries

    DEFF Research Database (Denmark)

    Hasselt, P.M. van; Koning, T.J. de; Vries, E. de;

    2008-01-01

    in infants with biliary atresia. PATIENTS AND METHODS: From Dutch and Danish national biliary atresia registries, we retrieved infants who were either breastfed and received 1 mg of oral vitamin K at birth followed by 25 microg of daily oral vitamin K prophylaxis (Netherlands, 1991-2003), 2 mg of oral...

  8. Preterm Birth and Adult Wealth: Mathematics Skills Count.

    Science.gov (United States)

    Basten, Maartje; Jaekel, Julia; Johnson, Samantha; Gilmore, Camilla; Wolke, Dieter

    2015-10-01

    Each year, 15 million babies worldwide are born preterm. Preterm birth is associated with adverse neurodevelopmental outcomes across the life span. Recent registry-based studies suggest that preterm birth is associated with decreased wealth in adulthood, but the mediating mechanisms are unknown. This study investigated whether the relationship between preterm birth and low adult wealth is mediated by poor academic abilities and educational qualifications. Participants were members of two British population-based birth cohorts born in 1958 and 1970, respectively. Results showed that preterm birth was associated with decreased wealth at 42 years of age. This association was mediated by decreased intelligence, reading, and, in particular, mathematics attainment in middle childhood, as well as decreased educational qualifications in young adulthood. Findings were similar in both cohorts, which suggests that these mechanisms may be time invariant. Special educational support in childhood may prevent preterm children from becoming less wealthy as adults.

  9. Research on Difference in High-risk Birth Defect Epidemic Cause between Zhuang People and Han People in Nanning%南宁壮族与汉族高发出生缺陷流行病因差异研究

    Institute of Scientific and Technical Information of China (English)

    蒋武; 覃頔; 黄永全; 韦金露; 言京礼

    2016-01-01

    Objective To know whether there is a national difference in the incidence rate between different high-risk birth defects in Nanning and study its causes, and summarize the strategies of reducing the incidence rate of birth defects accord-ing to various risk factors and realize the sound child rearing in Nanning region. Methods The exposed risk factors of par-ents of 1274 perinatal infants with birth defects in Nanning were given 1 : 1 matched case-control study, the relevant influ-ence factors were studied and analyzed, and the case data base was established by Excel, and then the data was analyzed and treated by SPSS16.0 statistical software. Results In the defect group, 574 cases were Zhuang people, 666 cases were Han people, the incidence rates of congenital heart disease, cleft palate , harelip and cleft palate, hypospadias and gas-troschisis in Han people were higher than those in Zhuang people, the incidence rates of harelip, congenital hydrocephalus, neural tube defect, fetal edema syndrome, esophageal a-tresia or stenosis, anorectum atresia or stenosis and con-genital diaphragmatic hernia in Zhuang people were high-er than those in Han people, and the differences had sta-tistical significance, living in the polluted environment, exposure to radiation or toxic chemicals during pregnancy, medication without guidance of doctors during pregnancy, age of pregnant women more than 35, congenital disease family history, chemical exposure history of fathers, smoking and alcohol history of fathers, nutrition of pregnant women and dysthymia during pregnancy were related to the birth defects, and all of them were risk factors of birth defects. Conclusion There is a difference in the high-risk birth defect epidemic cause be-tween Zhuang people and Han people in Nanning with national specificity, the intervention in predicting birth defects in our region can be conducted from the aspects of environment, bad living habits, vocational factor and mental factor to reduce

  10. CDC WONDER: Births

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Births (Natality) online databases in CDC WONDER report birth rates, fertility rates and counts of live births occurring within the United States to U.S....

  11. Birth Control Explorer

    Science.gov (United States)

    ... STIs Media Facebook Twitter Tumblr Shares · 467 Birth Control Explorer Sort by all methods most effective methods ... You are here Home » Birth Control Explorer Birth Control Explorer If you’re having sex —or if ...

  12. Birth control pills - combination

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000655.htm Birth control pills - combination To use the sharing features on ... both progestin and estrogen. What Are Combination Birth Control Pills? Birth control pills help keep you from ...

  13. Essure Permanent Birth Control

    Science.gov (United States)

    ... Prosthetics Essure Permanent Birth Control Essure Permanent Birth Control Share Tweet Linkedin Pin it More sharing options ... System Essure is a a permanently implanted birth control device for women (female sterilization). Implantation of Essure ...

  14. The Danish Heart Failure Registry

    DEFF Research Database (Denmark)

    Schjødt, Inge; Nakano, Anne; Egstrup, Kenneth

    2016-01-01

    AIM OF DATABASE: The aim of the Danish Heart Failure Registry (DHFR) is to monitor and improve the care of patients with incident heart failure (HF) in Denmark. STUDY POPULATION: The DHFR includes inpatients and outpatients (≥18 years) with incident HF. Reporting to the DHFR is mandatory...... in an annual report. All standards for the quality indicators have been met at a national level since 2014. Indicators for treatment status 1 year after diagnosis are under consideration (now prevalent HF). CONCLUSION: The DHFR is a valuable tool for continuous improvement of quality of care in patients...

  15. 中国30个县(市)1993~2000年神经管畸形在出生人群中的患病率及变动趋势分析%Prevalence of neural tube defects at birth in 30 counties and cities of China, 1993-2000

    Institute of Scientific and Technical Information of China (English)

    叶荣伟; 李松; 郑俊池; 洪世欣; 陈新; 王太梅; 任爱国; 王丽娜; 李竹

    2002-01-01

    Objective:To describe the prevalence rates of neural tube defects (NTD) and yearly trends (1993-2000) in China. Methods: All the data were obtained from the Birth Defects Surveillance System in thirty counties/cities of China. The calculation of NTD prevalence rates and time trend analyses were based on the data for live (L) and stillbirths (S) only, the denominator used was total births (L+S). Linear regression analysis of the prevalence rate over years has been used to measure time trends. Results: In the period of 1993-2000, there were 1 264 neural tube defects among 1 189 126 total births in 30 counties/cities in China. The overall neural tube defects rate was 10.63 per 10000 births, and rates were higher (18.99 per 10 000 births) in the year 1993, lower (6.05 per 10 000 births) in 1998. The prevalence rates of anencephaly, spina bifida and encephalocele were 4.71,4.39 and 1.53 per 10 000 births respectively. Of all index NTD cases, anencephaly and spina bifida were most frequent, making up 44.3% and 41.3%, and encephalocele represented 14.4%. The stillbirth proportion was 69.3% over all index NTD cases, 95.4% in anencephaly cases, 43.7% in spina bifida, and 62.6% in encephalocele cases. Linear trend analysis indicated a significant decline for NTD rate (F=11.818, β=-0.814,P=0.014). Analysis by specific defect showed significant declines for the rates of anencephaly (P=0.004) and spina bifida (P=0.026), but no significant annual variation of encephalocele (P=0.227). Results of comparing with data reported from other surveillance systems (1994-1999) showed that the highest NTD rate (9.41 per 10000 births) was seen in China, nearly7 times the lowest rate (1.44 per 10000 births) in England and Wales. Conclusion: The overall neural tube defects rate in 30 counties/cities of China presented a significant downward trend between 1993 and 2000, and China still had the higher neural tube defects prevalence. %目的:描述中国30个县(市)1993

  16. Urban and rural difference and educational difference of cognition degree of birth defect prevention in uygur autonomous region%维吾尔族聚居区出生缺陷预防认知度的城乡区别及文化差异

    Institute of Scientific and Technical Information of China (English)

    杨涛

    2016-01-01

    Objective To summarize the relationship of geography and education and cognition degree of birth defect prevention in Uygur Autonomous Region investigated in Urumqi, Uygur Autonomous Region of Xinjiang from January 2006 to July 2013. Methods Statistics of 322 children with birth defects from January 2006 to July 2013 in Urumqi, Uygur Autonomous Region of Xinjiang were summarized. And it was received combined analysis with geography and education of pregnant women to explore the relationship of geography and education and cognition degree of birth defect prevention. Results The awareness rates of unban pregnant women with the high education of at least college about pregnancy folic acid intake, dietary intake of iodine, avoiding environmental pollution, avoiding rubella virus, avoiding the use of teratogenic drugs, genetic defects, avoiding consanguineous marriage, the best eugenic age, pets feeding before and during pregnancy, prenatal diagnosis, avoid smoking and secondhand smoke, the significance of alpha-fetoprotein test and pregnancy tome after taking contraceptive drugs were significantly higher than those of rural pregnant women with the education of at most college (P<0.05). Conclusion Cognition degree of birth defect prevention has certain educational and geographic difference and it is also related to special geographic environment of Urumqi. Prevent birth defects has a certain degree of education and regional differences, and also with the county special geographical environment.%目的:总结新疆维吾尔自治区乌鲁木齐市2006年1月~2013年7月调查维吾尔族聚居区生长地域和文化程度与出生缺陷预防认知度之间的关系。方法总结新疆维吾尔自治区乌鲁木齐市2006年1月~2013年7月322例出生缺陷儿数据,并将其与孕妇地域和文化程度进行结合分析,统计地域和文化程度与出生缺陷预防认知度之间的关系。结果大学专科及以上文化及城镇孕

  17. Private provider participation in statewide immunization registries

    Directory of Open Access Journals (Sweden)

    Cowan Anne E

    2006-02-01

    Full Text Available Abstract Background Population-based registries have been promoted as an effective method to improve childhood immunization rates, yet rates of registry participation in the private sector are low. We sought to describe, through a national overview, the perspectives of childhood immunization providers in private practice regarding factors associated with participation or non-participation in immunization registries. Methods Two mailed surveys, one for 264 private practices identified as registry non-participants and the other for 971 identified as registry participants, from 15 of the 31 states with population-based statewide immunization registries. Frequency distributions were calculated separately for non-participants and participants regarding the physician-reported factors that influenced decisions related to registry participation. Pearson chi-square tests of independence were used to assess associations among categorical variables. Results Overall response rate was 62% (N = 756. Among non-participants, easy access to records of vaccines provided at other sites (N = 101, 68% and printable immunization records (N = 82, 55% were most often cited as "very important" potential benefits of a registry, while the most commonly cited barriers to participation were too much cost/staff time (N = 36, 38% and that the practice has its own system for recording and monitoring immunizations (N = 35, 37%. Among registry participants, most reported using the registry to input data on vaccines administered (N = 326, 87% and to review immunization records of individual patients (N = 302, 81%. A minority reported using it to assess their practice's immunization coverage (N = 110, 29% or generate reminder/recall notices (N = 54, 14%. Few participants reported experiencing "significant" problems with the registry; the most often cited was cost/staff time to use the registry (N = 71, 20%. Conclusion Most registry participants report active participation with few

  18. Offspring preterm birth and birth size are related to long-term risk of maternal diabetes

    DEFF Research Database (Denmark)

    Naver, Klara Vinsand; Secher, Niels Jørgen; Ovesen, Per Glud;

    2013-01-01

    of diabetes (n = 100,669). Registries were used to extract information on patients with a hospital or outpatient diagnosis of diabetes, subsequent deliveries, and death/emigration in the period from the index delivery until the end of 2006. The association between the maternal risk of diabetes and the index...... gestational age and index offspring birth size (birth weight adjusted for gestational age) was investigated by using Cox proportional hazards regression models stratified according to young (≤33 years) and old age (>33 years). During a median follow-up period of 24 years, 2,021 women (2.0 %) were diagnosed...... as having diabetes. The risk of maternal diabetes was positively associated with increasing index birth size and negatively associated with increasing duration of index gestation in both age strata. Among young women, the highest hazard ratios were found for the exposure category of large index offspring...

  19. Birth Weight and Attention-Deficit/Hyperactivity Symptoms in Childhood and Early Adolescence: A Prospective Swedish Twin Study

    Science.gov (United States)

    Hultman, Christina M.; Torrang, Anna; Tuvblad, Catherine; Cnattingius, Sven; Larsson, Jan-Olov; Lichtenstein, Paul

    2007-01-01

    Objective: To determine whether low birth weight increases the risk of attention-deficit/hyperactivity disorder (ADHD) in childhood and early adolescence. Method: In a population-based sample of 1,480 twin pairs born in the period 1985-1986 ascertained from the Swedish Twin Registry, birth weight was collected prospectively through the Medical…

  20. Prevalence, prenatal diagnosis and clinical features of oculo-auriculo-vertebral spectrum: a registry-based study in Europe.

    LENUS (Irish Health Repository)

    Barisic, Ingeborg

    2014-01-08

    Oculo-auriculo-vertebral spectrum is a complex developmental disorder characterised mainly by anomalies of the ear, hemifacial microsomia, epibulbar dermoids and vertebral anomalies. The aetiology is largely unknown, and the epidemiological data are limited and inconsistent. We present the largest population-based epidemiological study to date, using data provided by the large network of congenital anomalies registries in Europe. The study population included infants diagnosed with oculo-auriculo-vertebral spectrum during the 1990-2009 period from 34 registries active in 16 European countries. Of the 355 infants diagnosed with oculo-auriculo-vertebral spectrum, there were 95.8% (340\\/355) live born, 0.8% (3\\/355) fetal deaths, 3.4% (12\\/355) terminations of pregnancy for fetal anomaly and 1.5% (5\\/340) neonatal deaths. In 18.9%, there was prenatal detection of anomaly\\/anomalies associated with oculo-auriculo-vertebral spectrum, 69.7% were diagnosed at birth, 3.9% in the first week of life and 6.1% within 1 year of life. Microtia (88.8%), hemifacial microsomia (49.0%) and ear tags (44.4%) were the most frequent anomalies, followed by atresia\\/stenosis of external auditory canal (25.1%), diverse vertebral (24.3%) and eye (24.3%) anomalies. There was a high rate (69.5%) of associated anomalies of other organs\\/systems. The most common were congenital heart defects present in 27.8% of patients. The prevalence of oculo-auriculo-vertebral spectrum, defined as microtia\\/ear anomalies and at least one major characteristic anomaly, was 3.8 per 100 000 births. Twinning, assisted reproductive techniques and maternal pre-pregnancy diabetes were confirmed as risk factors. The high rate of different associated anomalies points to the need of performing an early ultrasound screening in all infants born with this disorder.European Journal of Human Genetics advance online publication, 8 January 2014; doi:10.1038\\/ejhg.2013.287.

  1. Windows registry forensics advanced digital forensic analysis of the Windows registry

    CERN Document Server

    Carvey, Harlan

    2011-01-01

    Harlan Carvey brings readers an advanced book on Windows Registry - the most difficult part of Windows to analyze in forensics! Windows Registry Forensics provides the background of the Registry to help develop an understanding of the binary structure of Registry hive files. Approaches to live response and analysis are included, and tools and techniques for postmortem analysis are discussed at length. Tools and techniques will be presented that take the analyst beyond the current use of viewers and into real analysis of data contained in the Registry. This book also has a DVD containing tools, instructions and videos.

  2. [Local registries in general/family practice].

    Science.gov (United States)

    Cindrić, Jasna

    2007-02-01

    Entering medical records into registries of all sorts has always been a part of everyday work of a general/family physician. There is a distinction between public/population registries on the one hand, and internal, local registries on the other hand. Local registries refer to the catchment population of a particular general/family practice. While keeping population-registries has become a routine with a high level of uniformity in collecting, delivering, recording, analyzing and controlling information, there are no recommendations or standards for keeping local registries, although their importance as well as indisputable necessity have been recognized. They are invaluable for providing an insight into the condition and history of a particular disease in a particular area, planning and taking preventive measures and activities, supervising therapy and medical treatment, as well as for statistical analyses and scientific studies. The most important registry in the field of general practice is the one called "List of health care under the supervision of chosen general/family physicians", which can serve as an index for any other individual record or record of diseases by name kept at a particular general/family practice. Although local registries have "evolved" from notebooks into modern informatic databases, the problem of up-to-dateness cannot be solved until the whole health care system has been connected for competent and authorized persons to be able to record changes of data where and when they take place.

  3. 50 CFR 600.1410 - Registry process.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Registry process. 600.1410 Section 600.1410 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... United States § 600.1410 Registry process. (a) A person may register through the NMFS web site at...

  4. Service registry design: an information service approach

    NARCIS (Netherlands)

    Ferreira Pires, Luis; Oostrum, van Arjen; Wijnhoven, Fons; Wang, J.

    2010-01-01

    A service registry is a Service-Oriented Architecture (SOA) component that keeps a ‘catalogue’ of available services. It stores service specifications so that these specifications can be found by potential users. Discussions on the design of service registries currently focus on technical issues, wh

  5. An epidemiological study about air pollution exposure and the perinatal birth defects in six sentinel hospitals of a certain city in China%大气污染暴露与某市6家哨点医院围生儿出生缺陷的流行病学研究

    Institute of Scientific and Technical Information of China (English)

    汤俊; 姚慈将; 张健; 操基玉

    2015-01-01

    目的:探讨和分析某市大气污染对新生儿出生缺陷的影响。方法收集某市6家哨点医院2012—2013年期间分娩的孕满18周到出生后7 d 内的所有围产儿资料,包括分娩日期、孕产妇孕周以及孕天数和围生儿的性别等资料。同时收集该市2011—2013年的大气污染物日监测资料,包括二氧化硫、二氧化氮、可吸入污染和污染指数等。采用 SPSS16.0软件进行一般性描述、卡方检验、方差分析、Spearman 秩相关等统计分析。结果2年出生缺陷总发生率为11.63‰;2012年的出生缺陷发生率为10.49‰,2013年为12.76‰,但2年之间差异无统计学意义(P >0.05);不同性别出生缺陷患儿的发生率差异有统计学意义(P <0.05),男婴出生缺陷发生率高于女婴。出生缺陷发生率与大气污染物的 Spearman 秩相关分析结果显示:在孕前1月组和孕前2月组,出生缺陷发生率与可吸入颗粒物(PM10)和污染指数呈正相关。结论该次调查的该市妊娠期妇女在妊娠前期2个月内,大气 PM10暴露浓度和污染指数暴露水平与出生缺陷的发生存在统计学关联。%Objective Objective To investigate and analyze the city air pollution effects on birth defects.Methods Data of perinatal fetus from 18 -week gestation to 7 days after the birth,including date of delivery,maternal gestational weeks,days of pregnancy and gender,were collected from six sentinel hospitals of a city during 2012—2013.The daily monitoring data of air pollutants from 2011 to 2013,including sulfur dioxide,nitrogen dioxide,inhaled pollution and pollution index,were collected at the same time.SPSS16.0 soft-ware was used for general description,chisquare test,analysis of variance and Spearman rank correlation.Results The total incidence of birth defects was 11.63 per thousand in 2 years.The incidence of birth defects was 10.49 per thousand in 2012,12.76 per thousand in 2013

  6. Central registry in psychiatry: A structured review

    Directory of Open Access Journals (Sweden)

    Jyoti Prakash

    2014-01-01

    Full Text Available Background: Central registry in psychiatry is being practiced in few countries and has been found useful in research and clinical management. Role of central registry has also expanded over the years. Materials and Methods: All accessible internet database Medline, Scopus, Embase were accessed from 1990 till date. Available data were systematically reviewed in structured manner and analyzed. Results: Central registry was found useful in epidemiological analysis, association studies, outcome studies, comorbidity studies, forensic issue, effective of medication, qualitative analysis etc., Conclusion: Central registry proves to be effective tool in quantitative and qualitative understanding of psychiatry practice. Findings of studies from central registry can be useful in modifying best practice and evidence based treatment in psychiatry.

  7. The Danish National Chronic Lymphocytic Leukemia Registry

    DEFF Research Database (Denmark)

    da Cunha-Bang, Caspar; Geisler, Christian Hartmann; Enggaard, Lisbeth;

    2016-01-01

    , and for decision on treatment initiation as well as characteristics included in the CLL International Prognostic Index are collected. DESCRIPTIVE DATA: To ensure full coverage of Danish CLL patients in the registry, both continuous queries in case of missing data, and cross-referencing with the Danish National......, 3,082 patients have been registered. CONCLUSION: The Danish National CLL Registry is based within the Danish National Hematology Database. The registry covers a cohort of all patients diagnosed with CLL in Denmark since 2008. It forms the basis for quality assessment of CLL treatment in Denmark......AIM: In 2008, the Danish National Chronic Lymphocytic Leukemia Registry was founded within the Danish National Hematology Database. The primary aim of the registry is to assure quality of diagnosis and care of patients with chronic lymphocytic leukemia (CLL) in Denmark. Secondarily, to evaluate...

  8. 孕母血浆同型半胱氨酸水平与胎儿出生缺陷的关系及其临床意义%Relationship between Maternal Plasma Homocysteine Level and Fetal Birth Defects and It′s Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    吴瑕; 柳国胜; 万波; 冯强

    2011-01-01

    Objective To determine the relationship between plasma homocysteine (Hcy) level in gestational period and fetal malformation, and the clinical significance in prenatal screening and prenatal diagnosis of birth defects. Methods Fifty - one cases of pregnant women confirmed (gestation) fetal malformation by prenatal diagnosis or after birth were enrolled as the study group,and then they were subdivided into 4 groups according to the different types of birth defects:congenital heart malformation group( group A), neural tube defects group( group B) ,cleft lip and palate group( group C) and other sort of malformations group( group D,except for group A ,B and C). In addition ,another 30 cases of the normal pregnant women and the fetus were selected randomly as healthy control group. Maternal peripheral blood and the specimens of fetal cord blood specimens were collected to detect Hcy by enzymatic cycling assay. Results 1. Umbilical Hcy values in the study group was (13.43 ± 6.57 ) μmol · L-1, which was significantly higher than that in the healthy control group [ (6.30 ± 1.38 ) μmol · L- 1 ]( t=5. 687, P=0. 000). 2. Mean concentrations of plasma Hcy in group A, group B, group C and group D were ( 12.22 ± 4.60 ) μmol · L- 1,(22.78 ± 7.42) μmol · L - 1 , ( 11.24 ± 3.42 ) μmol · L- 1, ( 13.44 ± 6.57 ) μmol · L - 1 , respectively, which were significantly higher than that in the healthy control group [ (6.87 ± 1.43 ) μmol · L-1 ] ( Pa =0. 000). 3. There was a positive correlation of Hcy values between pregnant women and the fetuses in the study group and the healthy control group ( r = 0. 922, P=0. 000 ). Conclusions 1. Maternal hyperhomocysteinemia in the gestational period is one of the risk factors for fetus birth defects,especially in congenital heart malformations, neural tube defects and congenital cleft lip and palate defects. 2. It suggests that the plasma Hcy can be taken as an indicator of prenatal screening for birth defects, and that the

  9. Atenção aos defeitos congênitos no Brasil: características do atendimento e propostas para formulação de políticas públicas em genética clínica Birth defects in Brazil and health care: proposals for public policies in clinical genetics

    Directory of Open Access Journals (Sweden)

    Dafne Dain Gandelman Horovitz

    2006-12-01

    Full Text Available O impacto dos defeitos congênitos no Brasil vem aumentando, apontando para a necessidade de estratégias específicas na política de saúde. Apesar da íntima ligação da genética clínica com a atenção aos defeitos congênitos, menos de 30% da demanda vem sendo absorvida pelos serviços do país. São problemas na atenção aos defeitos congênitos: dificuldades de acesso aos serviços de genética com concentração destes no Sul/Sudeste e suporte laboratorial insuficiente. Para melhor abordagem aos defeitos congênitos, ações para o estabelecimento de política em genética clínica deveriam ser deflagradas, preferencialmente sob coordenação de grupo técnico vinculado ao Ministério da Saúde, tendo como objetivo organizar rede clínico-laboratorial na especialidade. Ações visando à otimização de recursos e ao aumento da cobertura deverão ser consideradas. Para suporte laboratorial são prementes arranjos visando o fluxo de exames e criação de mecanismos de financiamento. Ações complementares de prevenção e registro epidemiológico dos defeitos congênitos, educação médica e do usuário são recomendadas. Com tais propostas contempladas, será possível a estruturação de uma rede regionalizada, hierarquizada e funcional, além de mais justa e mais democrática, voltada à atenção aos defeitos congênitos no Brasil.The impact of birth defects in Brazil has increased steadily, indicating the need for specific health policy strategies. Despite the close relationship between clinical genetics and management of birth defects, less than 30% of the total demand is currently met by existing genetic services. The main problems are: difficult access to genetic services, services highly concentrated in the South and Southeast regions of the country, and insufficient laboratory support. With the aim of improving management of birth defects, a specific national policy coordinated by the Ministry of Health needs to be

  10. 妊娠合并症与妊娠期接触化学毒物对出生缺陷影响的系统评价%Effect of pregnancy complications and gestational exposure to toxic chemical on birth defect:a systematic ;evaluation

    Institute of Scientific and Technical Information of China (English)

    岳书华; 万素馨

    2016-01-01

    目的:探讨妊娠合并症与妊娠期接触化学毒物对出生缺陷的影响,为制定最佳预防控制决策,实行有效的干预措施提供科学依据。方法根据纳入与排除标准进行文献评价与筛选,11篇文献纳入此次Meta 分析,累计病例3248例,对照5722例。由异质性检验结果决定采用固定或随机效应模型,并对合并结果进行χ2检验,同时应用漏斗图综合评估纳入文献的发表性偏倚。结果妊娠合并症的单因素分析合并效应值及其95%CI 为1.074(0.926~1.222),表明妊娠合并症是导致出生缺陷的危险因素;妊娠期接触化学毒物的单因素和多因素分析合并效应值及其95%CI 分别为1.426(1.147~1.704)、1.421(1.174~1.668),提示妊娠期接触化学毒物也是导致出生缺陷的危险因素。结论妊娠合并症和妊娠期接触化学毒物都是导致出生缺陷发生的危险因素,这为针对性预防出生缺陷的发生提供了参考。%Objective To investigate the impact of pregnancy complications and gestational exposure to toxic chemical on birth defect,to provide scientific basis for effective intervention measures.Methods 11 studies were included,the quality evaluation and information extraction were carried out on the studies according to include and exclude standard.3 248 examples in case group and 5 722 examples in control group.Fixed or random effects model was used according to heterogeneity test results,and the combined result was analyzed by Chi -square test.The publi-cation bias of the studies was also evaluated.Results The combined results of single factor analysis of pregnancy complications was 1.074(0.926 -1.222),showed that pregnancy complications were risk factors of birth defects.The combined results of single factor and multiple factors analysis of gestational exposure to toxic chemical were 1.426 (1.147 -1.704),1.421(1.174 -1.668),also showed that gestational

  11. A Pleasing Birth

    NARCIS (Netherlands)

    Vries, De Raymond

    2005-01-01

    Women have long searched for a pleasing birth-a birth with a minimum of fear and pain, in the company of supportive family, friends, and caregivers, a birth that ends with a healthy mother and baby gazing into each other's eyes. For women in the Netherlands, such a birth is defined as one at home un

  12. The Danish adult diabetes registry

    DEFF Research Database (Denmark)

    Jørgensen, Marit Eika; Kristensen, Jette K.; Husted, Gitte Reventlov

    2016-01-01

    Aim of the database: The aim of the Danish Adult Diabetes Registry (DADR) is to provide data from both the primary health care sector (general practice [GP]) and the secondary sector (specialized outpatient clinics) to assess the quality of treatment given to patients with diabetes. The indicators...... represent process and outcome indicators selected from the literature. Study population: The total diabetes population in Denmark is estimated to be ∼300,000 adult diabetes patients. Approximately 10% have type 1 diabetes, which is managed mainly in the secondary sector, and 90% have type 2 diabetes......, glucose-, blood pressure-, and lipid-lowering treatment (yes/no), insulin pump treatment (yes/ no), and date of last eye and foot examination. Descriptive data: In 2014, the annual report included data regarding over 38,000 patients from outpatient clinics, which is assumed to have included almost all...

  13. 孕前保健对某地区出生缺陷及其他不良妊娠结局影响的观察%Effect of preconception care on birth defect and other adverse pregnancy outcomes in A certain area

    Institute of Scientific and Technical Information of China (English)

    温小鲜; 陈桂玲; 梁建文; 陈凤仪; 陶小君; 陈莲芬; 李建萍; 王耀强; 张伟强; 赖剑锋

    2014-01-01

    Objective To explore the effect of preconception care on birth defect and other adverse pregnancy outcomes in Fanyu District. Methods Select 1000 sample size for research, 500 people who used of preconception care as the observation group, and 500 people without preconception care as the control group. Eugenic knowledge and awareness, taking the case of folic acid, prenatal care and treatment, adverse pregnancy outcomes of two groups were compared. Results Aware of knowledge about eugenics, the rate of taking folic acid and the treatment of chronic diseases coverage of observation group were significantly higher than the control group(P < 0.05); At 4 weeks pregnancy diagnosis rate and birth defects in prenatal screening coverage were significantly higher than the control group(P < 0.05), and the main risk factor for early pregnancy exposure levels was significantly lower than the observation group(P < 0.05); Preterm birth and Expired pregnancy rates, the incidence of neonatal asphyxia, and the incidence of birth defects were significantly lower than the control group(P < 0.05), and the amount of postpartum bleeding was significantly lower than the control group(P<0.05), the difference is statistically significant. Conclusion Preconception care can reduce birth defects, and improve the pregnancy outcome, we should further promote the smooth development of preconception care work.%目的:探讨孕前保健对广州市番禺区出生缺陷及其他不良妊娠结局的影响。方法选择1000个样本量进行研究,将进行孕前保健的500例设为观察组,未进行孕前保健的500例设为对照组,比较两组观察对象优生知识知晓率、叶酸服用情况、产前检查与治疗及不良妊娠结局等指标。结果观察组优生知识知晓率、叶酸服用率、慢性病的治疗覆盖率均明显优于对照组(P<0.05);观察组孕4周内妊娠确诊率、出生缺陷产前筛查覆盖率明显高于对照组,妊娠早期主

  14. Hypospadias - prevalence, birth weight and associated major congenital anomalies

    DEFF Research Database (Denmark)

    Nissen, Karin Baekgaard; Udesen, Ann; Garne, Ester

    2015-01-01

    of 16.9 per 10,000 births. The prevalence was significantly higher in 2000-2009 compared to 1986-1999 (plow birth weight) infants among cases with hypospadias. Infants with isolated hypospadias were more likely to have mild hypospadias (68......AIM: The aim of this study was to determine the prevalence of hypospadias over 24 years in a Danish population and to describe the relation to birth weight and associated major congenital anomalies. METHODS: Population-based study of all cases (live births, fetal deaths and elective terminations...... of pregnancy) with hypospadias born in the period 1986-2009 in Funen County and reported to the EUROCAT registry of congenital anomalies. Cases were included only if surgery for hypospadias was performed. RESULTS: 223 cases of hypospadias were registered during the period 1986-2009 with an overall prevalence...

  15. Status of human assisted reproduction in Spain: results from the new registry of Catalonia.

    Science.gov (United States)

    Bosser, Roser; Gispert, Rosa; Torné, Mar; Calaf, Joaquim

    2009-11-01

    The FIVCAT. NET database in Catalonia is the only official obligatory registry of human assisted reproduction practitioners in Spain. The present study assessed the effectiveness and outcomes of assisted reproduction over the period 2001-2005 relative to other established worldwide registries. The data analysed were derived from all centres conducting assisted reproduction in Catalonia, and included users of the services (resident and non-resident); all cycles performed; descriptive characteristics of the assisted reproduction procedures; and sociodemographic characteristics of the women. Effectiveness of assisted reproduction was measured by standard indicators such as rates of pregnancy and rates of live births per pregnancy. The results indicated that the preferred number of embryos for transfer changed from three to two over this period. Pregnancies per transfer improved from 33.2% to 37.1% (from 36.9% to 40.2% using fresh embryos and from to 18.4% to 27.0% with frozen embryos). Multiple births decreased from 50.1% to 38.6%, premature births from 37.5% to 28.3% and low-birth-weight infants from 38.0% to 25.6%. It is concluded that the conduct of assisted reproduction in Catalonia has improved considerably and compares favourably with other countries, not only with respect to the level of activity, but also the effectiveness and outcomes achieved, although the quality of the sociodemographic information requires improvement.

  16. The season of birth of schizophrenic, neurotic and psychiatrically normal twins.

    Science.gov (United States)

    Kendler, K S

    1982-08-01

    The quarter of birth of 536 schizophrenic, 1,991 neurotic and 12,085 psychiatrically normal twin pairs from the National Academy of Sciences-National Research Council Twin Registry was compared. When either all twin pairs, or only monozygotic or dizygotic twin pairs, were considered, no significant differences were found in the quarter of birth between the 3 groups. No difference in quarter of birth was found for twin pairs concordant versus discordant for schizophrenia. Despite the increased risk for intrauterine and perinatal complications in twin births, schizophrenic twins appear (at least) to be no more vulnerable than schizophrenic singletons to the seasonal gestation and birth-related insults which probably underlie the seasonality in schizophrenic births. Controlling for season of birth probably has little effect on the results of twin studies of schizophrenia.

  17. Multilevel factors influencing preterm birth in an urban setting

    Directory of Open Access Journals (Sweden)

    Saba W. Masho

    2014-01-01

    Full Text Available Racial disparity in preterm is a major problem in the US. Although significant strides have been made in identifying some of the risk factors, the complexities between community and individual factors are not understood. This study examines the influence of individual and community level factors affecting preterm birth among Black and White women in an urban setting. A 10-year live birth registry dataset from a mid-sized, racially diverse city was analyzed (N = 30,591. Data were geocoded and merged with block group level Census data. Five hierarchical models were examined using PROC GLIMMIX. Education, illicit drug use, pregnancy complications, previous preterm birth, paternal presence, inadequate and adequate plus prenatal care, and poverty were associated with preterm births in both Blacks and Whites. In Black women, increasing maternal age, maternal smoking, and a previous infant death were significant predictors of preterm births, which was not the case for White women. Residing in medium or high poverty neighborhoods resulted in 19% and 28% higher odds, respectively, of preterm