One-dimensional magnetophotonic crystals with magnetooptical double layers
International Nuclear Information System (INIS)
Berzhansky, V. N.; Shaposhnikov, A. N.; Prokopov, A. R.; Karavainikov, A. V.; Mikhailova, T. V.; Lukienko, I. N.; Kharchenko, Yu. N.; Golub, V. O.; Salyuk, O. Yu.; Belotelov, V. I.
2016-01-01
One-dimensional magnetophotonic microcavity crystals with nongarnet dielectric mirrors are created and investigated. The defect layers in the magnetophotonic crystals are represented by two bismuth-substituted yttrium iron garnet Bi:YIG layers with various bismuth contents in order to achieve a high magnetooptical response of the crystals. The parameters of the magnetophotonic crystal layers are optimized by numerical solution of the Maxwell equations by the transfer matrix method to achieve high values of Faraday rotation angle Θ F and magnetooptical Q factor. The calculated and experimental data agree well with each other. The maximum values of Θ F =–20.6°, Q = 8.1° at a gain t = 16 are obtained for magnetophotonic crystals with m = 7 pairs of layers in Bragg mirrors, and the parameters obtained for crystals with m = 4 and t = 8.5 are Θ F =–12.5° and Q = 14.3°. It is shown that, together with all-garnet and multimicrocavities magnetophotonic crystals, such structures have high magnetooptical characteristics.
One-dimensional magnetophotonic crystals with magnetooptical double layers
Energy Technology Data Exchange (ETDEWEB)
Berzhansky, V. N., E-mail: v.n.berzhansky@gmail.com; Shaposhnikov, A. N.; Prokopov, A. R.; Karavainikov, A. V.; Mikhailova, T. V. [V.I. Vernadsky Crimean Federal University (Russian Federation); Lukienko, I. N.; Kharchenko, Yu. N., E-mail: kharcenko@ilt.kharkov.ua [National Academy of Sciences of Ukraine, Verkin Institute for Low Temperature Physics and Engineering (Ukraine); Golub, V. O., E-mail: v-o-golub@yahoo.com; Salyuk, O. Yu. [National Academy of Sciences of Ukraine, Institute of Magnetism (Ukraine); Belotelov, V. I., E-mail: belotelov@physics.msu.ru [Russian Quantum Center (Russian Federation)
2016-11-15
One-dimensional magnetophotonic microcavity crystals with nongarnet dielectric mirrors are created and investigated. The defect layers in the magnetophotonic crystals are represented by two bismuth-substituted yttrium iron garnet Bi:YIG layers with various bismuth contents in order to achieve a high magnetooptical response of the crystals. The parameters of the magnetophotonic crystal layers are optimized by numerical solution of the Maxwell equations by the transfer matrix method to achieve high values of Faraday rotation angle Θ{sub F} and magnetooptical Q factor. The calculated and experimental data agree well with each other. The maximum values of Θ{sub F} =–20.6°, Q = 8.1° at a gain t = 16 are obtained for magnetophotonic crystals with m = 7 pairs of layers in Bragg mirrors, and the parameters obtained for crystals with m = 4 and t = 8.5 are Θ{sub F} =–12.5° and Q = 14.3°. It is shown that, together with all-garnet and multimicrocavities magnetophotonic crystals, such structures have high magnetooptical characteristics.
Controllable Tamm states in magnetophotonic crystal
International Nuclear Information System (INIS)
Merzlikin, A.M.; Vinogradov, A.P.; Dorofeenko, A.V.; Inoue, M.; Levy, M.; Granovsky, A.B.
2007-01-01
We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field
Controllable Tamm states in magnetophotonic crystal
Energy Technology Data Exchange (ETDEWEB)
Merzlikin, A.M. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Vinogradov, A.P. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation)]. E-mail: a-vinogr@yandex.ru; Dorofeenko, A.V. [Institute for Theoretical and Applied Electromagnetics, Russian Academy of Science, 13/19 Izhorskaya ul., 125412 Moscow (Russian Federation); Inoue, M. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Levy, M. [Department of Physics, Michigan Technological University, 1400 Townsend Drive Houghton, MI 49931-1295 (United States); Granovsky, A.B. [Faculty of Physics, M.V. Lomonosov Moscow State University, Vorob' evy Gory, 119992 Moscow (Russian Federation)
2007-05-15
We study the Tamm states existing at the interface of a 1D magnetophotonic crystal made of magneto-optic material and a material with natural anisotropy. It is shown that in such a photonic crystal (PC) Yeh's band gap may exist, which causes a special type of the Tamm state. As this state is due to magneto-optic properties, it is controllable by an external magnetic field.
International Nuclear Information System (INIS)
Caicedo, J.M.; Taboada, E.; Hrabovsky, D.; Lopez-Garcia, M.; Herranz, G.; Roig, A.; Blanco, A.; Lopez, C.; Fontcuberta, J.
2010-01-01
We report here on the fabrication and characterization of magnetophotonic crystals obtained by infiltrating magnetic nanoparticles (maghemite) into silica-based inverse opals. Good quality opals, with adjustable photonic and magnetic characteristics have been obtained by this method. Magnetic and magneto-optic measurements, performed by using SQUID magnetometry and Kerr and Faraday effects, have been used to monitor the magnetic filling of the opals. It is observed that the Kerr rotation is not proportional to the overall magnetization of the magnetophotonic crystal. Possible scenarios for this unexpected result are discussed.
Three-dimensional magnetophotonic crystals based on artificial opals
Baryshev, A. V.; Kodama, T.; Nishimura, K.; Uchida, H.; Inoue, M.
2004-06-01
We fabricated and experimentally investigated three-dimensional magnetophotonic crystals (3D MPCs) based on artificial opals. Opal samples with three-dimensional dielectric lattices were impregnated with different types of magnetic material. Magnetic and structural properties of 3D MPCs were studied by field emission scanning electron microscopy, x-ray diffraction analysis, and vibrating sample magnetometer. We have shown that magnetic materials synthesized in voids of opal lattices and the composites obtained have typical magnetic properties.
Three-dimensional magnetophotonic crystals based on artificial opals
International Nuclear Information System (INIS)
Baryshev, A.V.; Kodama, T.; Nishimura, K.; Uchida, H.; Inoue, M.
2004-01-01
We fabricated and experimentally investigated three-dimensional magnetophotonic crystals (3D MPCs) based on artificial opals. Opal samples with three-dimensional dielectric lattices were impregnated with different types of magnetic material. Magnetic and structural properties of 3D MPCs were studied by field emission scanning electron microscopy, x-ray diffraction analysis, and vibrating sample magnetometer. We have shown that magnetic materials synthesized in voids of opal lattices and the composites obtained have typical magnetic properties
Magnetophotonics from theory to applications
Inoue, Mitsuteru; Baryshev, Alexander V
2013-01-01
Focused on light-to-artificial magnetic matter phenomena, this book explores magnetophotonics, describing and analyzing consequences of light interaction with non-reciprocal media. Covers light-to-artificial magnetic matter phenomena and related applications.
Optical Tamm states in one-dimensional magnetophotonic structures.
Goto, T; Dorofeenko, A V; Merzlikin, A M; Baryshev, A V; Vinogradov, A P; Inoue, M; Lisyansky, A A; Granovsky, A B
2008-09-12
We demonstrate the existence of a spectrally narrow localized surface state, the so-called optical Tamm state, at the interface between one-dimensional magnetophotonic and nonmagnetic photonic crystals. The state is spectrally located inside the photonic band gaps of each of the photonic crystals comprising this magnetophotonic structure. This state is associated with a sharp transmission peak through the sample and is responsible for the substantial enhancement of the Faraday rotation for the corresponding wavelength. The experimental results are in excellent agreement with the theoretical predictions.
The Faraday effect in two-dimensional magneto-photonic crystals
International Nuclear Information System (INIS)
Merzlikin, A.M.; Vinogradov, A.P.; Inoue, M.; Khanikaev, A.B.; Granovsky, A.B.
2006-01-01
The necessary conditions for the observation of the Faraday effect in 2D magneto-photonic crystals are discussed. It is found. that the Faraday effect may be observed in the directions where any couple of the wave vectors of the harmonics consisting the Bloch waves of TE and TM solutions in zero magnetic field are identical. This direction corresponds neither to Faraday nor to Voigt geometry
The Faraday effect in two-dimensional magneto-photonic crystals
Energy Technology Data Exchange (ETDEWEB)
Merzlikin, A.M. [Institute for Theoretical and Applied Electromagnetism, OIVT, Russian Academy of Sciences, Izhorskay 13/19, Moscow 125412 (Russian Federation)]. E-mail: merzlikin_a@mail.ru; Vinogradov, A.P. [Institute for Theoretical and Applied Electromagnetism, OIVT, Russian Academy of Sciences, Izhorskay 13/19, Moscow 125412 (Russian Federation); Inoue, M. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1, Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Khanikaev, A.B. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1, Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Granovsky, A.B. [Faculty of Physics, Lomonosov Moscow State University, Leninski Gory, Moscow 119992 (Russian Federation)
2006-05-15
The necessary conditions for the observation of the Faraday effect in 2D magneto-photonic crystals are discussed. It is found. that the Faraday effect may be observed in the directions where any couple of the wave vectors of the harmonics consisting the Bloch waves of TE and TM solutions in zero magnetic field are identical. This direction corresponds neither to Faraday nor to Voigt geometry.
Modeling and optimization of nonreciprocal transmission through 2D magnetophotonic crystal
Energy Technology Data Exchange (ETDEWEB)
Vanwolleghem, M; Halagacka, L; Magdenko, L; Beavillain, P; Dagens, B [Institut d' Electronique Fondamentale, UMR CNRS 8622, Universite Paris-Sud, Orsay (France); Postava, K, E-mail: mathias.vanwolleghem@u-psud.fr, E-mail: kamil.postava@vsb.cz [Department of Physics, Technical University of Ostrava, 708 33 Ostrava (Czech Republic)
2011-07-06
A combination of unique magneto-optic (MO) non-reciprocity and photonic band gap in periodic structures is promising for efficient enhancement of optical isolation and integrated isolator applications [M. Vanwolleghem et al, Phys. Rev. B 80 (2009) 121102(R)]. In this paper we model and optimize a novel magneto-photonic crystal structure consisting air holes in transparent magneto-optic material in transverse geometry (Bismuth iron garnet ({epsilon}{sub xx} = 6.25 and {epsilon}{sub yz} = 0.1 i) at wavelength {lambda} = 1300 nm). Such a system with reduced symmetry shows an unidirectional bandgap. The model is based on plane wave Fourier expansion of the field inside the periodic system using RCWA. While in the forward direction the structure transmit the light in the backward direction it shows a band gap and transmission is almost forbidden.
Energy Technology Data Exchange (ETDEWEB)
Inoue, M [Toyohashi University of Technology, Toyohashi, Aichi 441-8580 (Japan); Fujikawa, R [Toyohashi University of Technology, Toyohashi, Aichi 441-8580 (Japan); Baryshev, A [Toyohashi University of Technology, Toyohashi, Aichi 441-8580 (Japan); Khanikaev, A [Toyohashi University of Technology, Toyohashi, Aichi 441-8580 (Japan); Lim, P B [CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan (Japan); Uchida, H [Toyohashi University of Technology, Toyohashi, Aichi 441-8580 (Japan); Aktsipetrov, O [Lomonosov Moscow State University, Leninskie Gory, Moscow, 119992 (Russian Federation); Fedyanin, A [Lomonosov Moscow State University, Leninskie Gory, Moscow, 119992 (Russian Federation); Murzina, T [Lomonosov Moscow State University, Leninskie Gory, Moscow, 119992 (Russian Federation); Granovsky, A [Lomonosov Moscow State University, Leninskie Gory, Moscow, 119992 (Russian Federation)
2006-04-21
When the constitutive materials of photonic crystals (PCs) are magnetic, or even only a defect introduced in PCs is magnetic, the resultant PCs exhibit very unique optical and magneto-optical properties. The strong photon confinement in the vicinity of magnetic defects results in large enhancement in linear and nonlinear magneto-optical responses of the media. Novel functions, such as band Faraday effect, magnetic super-prism effect and non-reciprocal or magnetically controllable photonic band structure, are predicted to occur theoretically. All the unique features of the media arise from the existence of magnetization in media, and hence they are called magnetophotonic crystals providing the spin-dependent nature in PCs. (topical review)
International Nuclear Information System (INIS)
Inoue, M; Fujikawa, R; Baryshev, A; Khanikaev, A; Lim, P B; Uchida, H; Aktsipetrov, O; Fedyanin, A; Murzina, T; Granovsky, A
2006-01-01
When the constitutive materials of photonic crystals (PCs) are magnetic, or even only a defect introduced in PCs is magnetic, the resultant PCs exhibit very unique optical and magneto-optical properties. The strong photon confinement in the vicinity of magnetic defects results in large enhancement in linear and nonlinear magneto-optical responses of the media. Novel functions, such as band Faraday effect, magnetic super-prism effect and non-reciprocal or magnetically controllable photonic band structure, are predicted to occur theoretically. All the unique features of the media arise from the existence of magnetization in media, and hence they are called magnetophotonic crystals providing the spin-dependent nature in PCs. (topical review)
Permittivity disorder induced Anderson localization in magnetophotonic crystals
Energy Technology Data Exchange (ETDEWEB)
Abdi-Ghaleh, R., E-mail: r.abdi@bonabu.ac.ir [Department of Laser and Optical Engineering, University of Bonab, 5551761167 Bonab (Iran, Islamic Republic of); Namdar, A. [Faculty of Physics, University of Tabriz, 5166614766 Tabriz (Iran, Islamic Republic of)
2016-11-15
This theoretical study was carried out to investigate the permittivity disorder induced Anderson localization of light in one-dimensional magnetophotonic crystals. It was shown that the disorder create the resonant transmittance modes associated with enhanced Faraday rotations inside the photonic band gap. The average localization length of the right- and left-handed circular polarizations (RCP and LCP), the total transmittance together with the ensemble average of the RCP and LCP phases, and the Faraday rotation of the structure were also investigated. For this purpose, the off-diagonal elements of the permittivity tensor were varied for various wavelengths of incident light. The obtained results revealed the nonreciprocal property of circular eigen modes. This study can potentially open up a new aspect for utilizing the disorder magnetophotonic structures in nonreciprocal systems such as isolators and circulators. - Highlights: • We theoretically investigated the permittivity disorder induced Anderson localization of light in magnetophotonic crystals. • The disorder considered in the diagonal elements of the permittivity tensor of magneto-optical layers. • The disorder create the resonant transmittance modes associated with enhanced Faraday rotations in the photonic band gap. • The average localization length of the circular polarizations and the ensemble average of their phases were investigated. • The obtained results revealed the nonreciprocal property of circular eigen modes.
Giant photonic Hall effect in magnetophotonic crystals.
Merzlikin, A M; Vinogradov, A P; Inoue, M; Granovsky, A B
2005-10-01
We have considered a simple, square, two-dimensional (2D) PC built of a magneto-optic matrix with square holes. It is shown that using such a magnetophotonic crystal it is possible to deflect a light beam at very large angles by applying a nonzero external magnetic field. The effect is called the giant photonic Hall effect (GPHE) or the magnetic superprism effect. The GPHE is based on magneto-optical properties, as is the photonic Hall effect [B. A. van Tiggelen and G. L. J. A. Rikken, in, edited by V. M. Shalaev (Springer-Verlag, Berlin, 2002), p. 275]; however GPHE is not caused by asymmetrical light scattering but rather by the influence of an external magnetic field on the photonic band structure.
Enhancement of Faraday rotation at photonic-band-gap edge in garnet-based magnetophotonic crystals
International Nuclear Information System (INIS)
Zhdanov, A.G.; Fedyanin, A.A.; Aktsipetrov, O.A.; Kobayashi, D.; Uchida, H.; Inoue, M.
2006-01-01
Spectral dependences of Faraday rotation angle in one-dimensional garnet-based magnetophotonic crystals are considered. The enhancement of Faraday angle is demonstrated at the photonic band gap (PBG) edge both theoretically and experimentally. It is shown to be associated with the optical field localization in the magnetic layers of the structure. The advantages of magnetophotonic crystals in comparison with traditional magnetic microcavities are discussed. The specially designed microcavity structures optimized for the Faraday effect enhancement at the PBG edge are suggested
Zero-birefringence pressure-sensitive adhesives
Directory of Open Access Journals (Sweden)
Hiroto Ito
2012-06-01
Full Text Available We have developed zero-birefringence pressure-sensitive adhesives (PSAs that exhibit almost no birefringence at any orientation of polymer chains. To evaluate the birefringence of PSAs quantitatively, we report a novel birefringence-measurement method utilizing zero–zero-birefringence polymers that exhibit no birefringence at any orientation of polymer chains and in elastic deformation. By employing this method, we designed and synthesized poly(butyl acrylate/phenoxyethyl acrylate/acrylic acid/hydroxyethyl acrylate = 80.0:20.0:1.5:1.0 (by weight that contains 1.8 wt% isocyanate-type crosslinker that exhibited almost zero birefringence. Furthermore, we demonstrated that after the accelerated aging test by applying heat, this zero-birefringence PSA almost completely prevented light leakage through crossed polarizers.
Microdroplet-etched highly birefringent low-loss fiber tapers.
Mikkelsen, Jared C; Poon, Joyce K S
2012-07-01
We use hydrofluoric acid microdroplets to directly etch highly birefringent biconical fiber tapers from standard single-mode fibers. The fiber tapers have micrometer-sized cross sections, which are controlled by the etching condition. The characteristic teardrop cross section leads to a high group birefringence of B(G)≈0.017 and insertion losses <0.7 dB over waist lengths of about 2.1 mm.
International Nuclear Information System (INIS)
Madruga, Carla; Filho, Paulo Alliprandini; Andrade, Marta M.; Goncalves, Manuel; Raposo, Maria; Ribeiro, Paulo A.
2011-01-01
Photoinduced birefringence creation/decay dynamics in poly{1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt}cast films, has been characterized in the 5 to 100 mW writing laser power range at the wavelength of 514 nm. The maximum birefringence magnitude increased with laser beam power, being the largest value of 0.03, measured at 632.8 nm. Birefringence creation kinetics followed a biexponential behavior, where a slow process and a fast process could be clearly distinguished. The fast process accounted for more than 60% of birefringence. The time constants for both fast and slow processes decreased with increasing power of writing beam. Birefringence relaxation after removal of writing laser beam revealed to be independent of beam power and, was found to be ruled by two processes, described by a biexponential curve plus a constant term accounting for residual birefringence. A high residual birefringence signal of 85 ± 3% was attained, with the fast process contributing to 67% of decay from maximum value. The large values obtained for time constants for both birefringence creation and relaxation processes are believed to arise from stabilization of azo-group either by the formation of an ionic network, or by local short range interactions that are coming through as a result polyelectrolyte coiling due to its high degree of ionization.
Temporal coupled mode analysis of one-dimensional magneto-photonic crystals with cavity structures
Energy Technology Data Exchange (ETDEWEB)
Saghirzadeh Darki, Behnam, E-mail: b.saghirzadeh@ec.iut.ac.ir; Zeidaabadi Nezhad, Abolghasem; Firouzeh, Zaker Hossein
2016-12-01
In this paper, we propose the time-dependent coupled mode analysis of one-dimensional magneto-photonic crystals including one, two or multiple defect layers. The performance of the structures, namely the total transmission, Faraday rotation and ellipticity, is obtained using the proposed method. The results of the developed analytic approach are verified by comparing them to the results of the exact numerical transfer matrix method. Unlike the widely used numerical method, our proposed analytic method seems promising for the synthesis as well as the analysis purposes. Moreover, the proposed method has not the restrictions of the previously examined analytic methods. - Highlights: • A time-dependent coupled mode analysis is proposed for the cavity-type 1D MPCs. • Analytical formalism is presented for the single, double and multiple-defect MPCs. • Transmission, Faraday rotation and ellipticity are gained using the proposed method. • The proposed analytic method has advantages over the previously examined methods.
Transverse Kerr effect in one-dimensional magnetophotonic crystals: Experiment and theory
International Nuclear Information System (INIS)
Erokhin, S.; Boriskina, Yu.; Vinogradov, A.; Inoue, M.; Kobayashi, D.; Fedyanin, A.; Gan'shina, E.; Kochneva, M.; Granovsky, A.
2006-01-01
Magneto-optical transverse Kerr and Faraday effects are studied experimentally and theoretically in one-dimensional magnetophotonic crystals fabricated from a stack of four repetitions of layers of Bi-substituted yttrium iron garnet and SiO 2 layers. The results of theoretical calculations in the framework of modified matrices approach are consistent with the obtained experimental data with the exception of the one cusp at 480 nm in the transverse Kerr effect spectra. Possible mechanisms of this disagreement are discussed
International Nuclear Information System (INIS)
Shaposhnikov, A.N.; Karavainikov, A.V.; Prokopov, A.R.; Berzhansky, V.N.; Salyuk, O.Y.
2012-01-01
Graphical abstract: Faraday hysteresis loops for Bi 1.0 Y 0.5 Gd 1.5 Fe 4.2 Al 0.8 O 12 film on glass-ceramic substrate (a), Bi 2.8 Y 0.2 Fe 5 O 12 film on gallium–gadolinium garnet (b) and for glass-ceramic/SiO 2 /Bi 1.0 Y 0.5 Gd 1.5 Fe 4.2 Al 0.8 O 12 /Bi 2.8 Y 0.2 Fe 5 O 12 structure (c). Highlights: ► Bismuth-substituted iron garnet films as magneto-optical layers in magneto-photonic crystals. ► It is impossible to crystallize the films with high Bi content on amorphous substrates. ► The crystallization of the films can be achieved by their deposition on buffer layer with low bismuth content. -- Abstract: The crystallization processes in Bi 2.8 Y 0.2 Fe 5 O 12 , Bi 2.5 Gd 0.5 Fe 3.8 Al 1.2 O 12 , Bi 1.5 Gd 1.5 Fe 4.5 Al 0.5 O 12 and Bi 1.0 Y 0.5 Gd 1.5 Fe 4.2 Al 0.8 O 12 garnet films deposited by reactive ion beam sputtering on (1 1 1) gadolinium–gallium garnet substrates, optical glass-ceramic and SiO 2 films have been studied. Films were annealed at low pressure in oxygen atmosphere and in the air. The possibility of preparation of crystalline garnet films with high concentration of bismuth on the SiO 2 films using a buffer layer with low concentration of Bi has been shown. This allows to produce one-dimensional magneto-photonic crystals with high effective Faraday rotation (several tens of°/μm for the visible optical spectrum).
Transverse Kerr effect in one-dimensional magnetophotonic crystals: Experiment and theory
Energy Technology Data Exchange (ETDEWEB)
Erokhin, S. [Faculty of Physics, Lomonosov Moscow State University, 11992 Moscow (Russian Federation)]. E-mail: yerokhin@magn.ru; Boriskina, Yu. [Faculty of Physics, Lomonosov Moscow State University, 11992 Moscow (Russian Federation); Vinogradov, A. [Institute for Theoretical and Applied Electrodynamics, Izhorskaya 13/19, 127412 Moscow (Russian Federation); Inoue, M. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Kobayashi, D. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibari-Ga-Oka, Tempaku, Toyohashi 441-8580 (Japan); Fedyanin, A. [Faculty of Physics, Lomonosov Moscow State University, 11992 Moscow (Russian Federation); Gan' shina, E. [Faculty of Physics, Lomonosov Moscow State University, 11992 Moscow (Russian Federation); Kochneva, M. [Faculty of Physics, Lomonosov Moscow State University, 11992 Moscow (Russian Federation); Granovsky, A. [Faculty of Physics, Lomonosov Moscow State University, 11992 Moscow (Russian Federation)
2006-05-15
Magneto-optical transverse Kerr and Faraday effects are studied experimentally and theoretically in one-dimensional magnetophotonic crystals fabricated from a stack of four repetitions of layers of Bi-substituted yttrium iron garnet and SiO{sub 2} layers. The results of theoretical calculations in the framework of modified matrices approach are consistent with the obtained experimental data with the exception of the one cusp at 480 nm in the transverse Kerr effect spectra. Possible mechanisms of this disagreement are discussed.
Energy Technology Data Exchange (ETDEWEB)
Nakamura, K.; Takagi, H., E-mail: takagi@ee.tut.ac.jp; Lim, P. B.; Inoue, M., E-mail: inoue@tut.ac.jp [Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Aichi 441 8580 (Japan); Goto, Taichi [Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Aichi 441 8580 (Japan); JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012 (Japan); Horimai, H. [HolyMine Corporation, Atsugi, Kanagawa 243 0813 (Japan); Yoshikawa, H. [Department of Computer Engineering, College of Science and Technology, Nihon University, Funabashi, Chiba 274 8501 (Japan); Bove, V. M. [MIT Media Lab, Cambridge, Massachusetts 02139 (United States)
2016-01-11
We have developed three-dimensional magneto-optic spatial light modulators (3D-MOSLMs) that use magnetic domains as submicron scale pixels to represent holograms. Our display system uses a submicron-scale magnetic pixel array on an amorphous TbFe film to create a wide viewing angle hologram. However, in previous work the reconstructed images had a low intensity and a low optical contrast; brightness of the reconstructed image was 4.4 × 10{sup −2 }cd/m{sup 2} with 532 nm illumination light at 10.8 mW/cm{sup 2}, while display standard ISO13406 recommends 100 cd/m{sup 2} or more. In this paper, we describe our development of a 3D-MOSLM composed of an artificial magnetic lattice structure of magnetophotonic crystals (MPCs). The MPCs enhance the diffraction efficiency of reconstructed 3D images and reduce the power consumption for controlling the magnetic pixels by a light localization effect. We demonstrate reconstructed 3D images using the MPC and show significant brightness improvement.
High-birefringent photonic crystal fiber
DEFF Research Database (Denmark)
Libori, Stig E. Barkou; Broeng, Jes; Knudsen, Erik
2001-01-01
A highly birefringent photonic crystal fiber design is analysed. Birefringence up to 10-3 is found. Random fluctuations in the cladding design are analysed, and the fiber is found to be a feasible polarization maintaining fiber.......A highly birefringent photonic crystal fiber design is analysed. Birefringence up to 10-3 is found. Random fluctuations in the cladding design are analysed, and the fiber is found to be a feasible polarization maintaining fiber....
Energy Technology Data Exchange (ETDEWEB)
Shaposhnikov, A.N.; Karavainikov, A.V.; Prokopov, A.R.; Berzhansky, V.N. [Taurida National V.I. Vernadsky University, Vernadsky Av., 4, 95007 Simferopol (Ukraine); Salyuk, O.Y., E-mail: olga-saliuk@yandex.ru [Institute of Magnetizm NASU and MESU, 36-B Vernadsky Blvd., 03142 Kiev (Ukraine)
2012-06-15
Graphical abstract: Faraday hysteresis loops for Bi{sub 1.0}Y{sub 0.5}Gd{sub 1.5}Fe{sub 4.2}Al{sub 0.8}O{sub 12} film on glass-ceramic substrate (a), Bi{sub 2.8}Y{sub 0.2}Fe{sub 5}O{sub 12} film on gallium–gadolinium garnet (b) and for glass-ceramic/SiO{sub 2}/Bi{sub 1.0}Y{sub 0.5}Gd{sub 1.5}Fe{sub 4.2}Al{sub 0.8}O{sub 12}/Bi{sub 2.8}Y{sub 0.2}Fe{sub 5}O{sub 12} structure (c). Highlights: ► Bismuth-substituted iron garnet films as magneto-optical layers in magneto-photonic crystals. ► It is impossible to crystallize the films with high Bi content on amorphous substrates. ► The crystallization of the films can be achieved by their deposition on buffer layer with low bismuth content. -- Abstract: The crystallization processes in Bi{sub 2.8}Y{sub 0.2}Fe{sub 5}O{sub 12}, Bi{sub 2.5}Gd{sub 0.5}Fe{sub 3.8}Al{sub 1.2}O{sub 12}, Bi{sub 1.5}Gd{sub 1.5}Fe{sub 4.5}Al{sub 0.5}O{sub 12} and Bi{sub 1.0}Y{sub 0.5}Gd{sub 1.5}Fe{sub 4.2}Al{sub 0.8}O{sub 12} garnet films deposited by reactive ion beam sputtering on (1 1 1) gadolinium–gallium garnet substrates, optical glass-ceramic and SiO{sub 2} films have been studied. Films were annealed at low pressure in oxygen atmosphere and in the air. The possibility of preparation of crystalline garnet films with high concentration of bismuth on the SiO{sub 2} films using a buffer layer with low concentration of Bi has been shown. This allows to produce one-dimensional magneto-photonic crystals with high effective Faraday rotation (several tens of°/μm for the visible optical spectrum).
Magnetoelectric Jones birefringence and dichroism in a medium of free atoms
International Nuclear Information System (INIS)
Mironova, P V; Ovsiannikov, V D; Chernushkin, V V
2006-01-01
Theoretical treatment of the magnetoelectric Jones birefringence and dichroism is developed through the bilinearity in static electric and magnetic field dipole-forbidden corrections to the amplitude of Rayleigh scattering. In particular cases of orientation of the static fields relative to the polarization and wave vectors of monochromatic radiation, the amplitude determines corrections to the refractive index of atomic gas responsible for (i) the Jones birefringence and dichroism (ii) linear birefringence and dichroism and (iii) directional anisotropy for the monochromatic wave. The analytical equations and numerical data for the indicated corrections, calculated for alkaline-earth-like atoms, determine optimal conditions for observing the effects in vapours. For resonance on 1 D 2 state essential enhancement is discovered in the frequency dependence for the ratio of refractive index anisotropy of the Jones effect to the square-root product of corresponding anisotropies determining the Kerr and Cotton-Mouton effects
Energy Technology Data Exchange (ETDEWEB)
Fang, Yun-Tuan [Jiangsu Univ., Zhenjiang (China). School of Computer Science and Telecommunication Engineering; Han, Ling [The Second Military Medical Univ., Shanghai (China). Dept. of Radiation Medicine; Gao, Yong-Feng [Jiangsu Univ., Zhenjiang (China). School of Mechanical Engineering
2015-07-01
Evanescently coupled Tamm states are achieved through two magnetophotonic crystals (MPCs) with a pair of coupling prisms. At the wavelengths of coupled Tamm states, a double of nonreciprocal optical tunnelling channels is found through the transmission spectra obtained from a developed transfer matrix method. The nonreciprocal tunnelling wavelength and the interval between two nonreciprocal channels can be adjusted depending on the width of the air gap between two MPCs or the scale invariant of a PC. The nonreciprocal tunnelling is demonstrated through electromagnetic field distribution simulations based on finite element software. Such theoretical results may provide a new method to design tunable optical isolators with a double of channels.
Onuma, Takashi; Otani, Yukitoshi
2014-03-01
A two-dimensional birefringence distribution measurement system with a sampling rate of 1.3 MHz is proposed. A polarization image sensor is developed as core device of the system. It is composed of a pixelated polarizer array made from photonic crystal and a parallel read out circuit with a multi-channel analog to digital converter specialized for two-dimensional polarization detection. By applying phase shifting algorism with circularly-polarized incident light, birefringence phase difference and azimuthal angle can be measured. The performance of the system is demonstrated experimentally by measuring actual birefringence distribution and polarization device such as Babinet-Soleil compensator.
TM-TE hybridization and tunable refraction in magnetophotonic crystals
Energy Technology Data Exchange (ETDEWEB)
Khanikaev, A.B. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1, Hibari-Ga-Oka, Toyohashi 441-8580 (Japan)]. E-mail: khanikaev@maglab.eee.tut.ac.jp; Inoue, M. [Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1, Hibari-Ga-Oka, Toyohashi 441-8580 (Japan); Granovsky, A.B. [Faculty of Physics, Lomonosov Moscow State University, Leninski Gory, Moscow 119992 (Russian Federation)
2006-05-15
In the present work we study the photonic band structure (PBS) and the polarization state of the Bloch eigenmodes of a two-dimensional magnetophotonic crystal (MPC) with square lattice formed from magneto-optically (MO) active cylinders. The refraction of light at the boundary of the MPC is analyzed. We found that both-the PBS and eigenmodes of the MPC-are most significantly altered by the MO activity in the vicinity of the degeneracies. For this case we demonstrated the possibility of an abrupt change in the propagation direction of light by the application of a magnetic field. For the Bloch wave vectors and frequencies corresponding to non-degenerate branches, the alteration of the PBS is shown to be negligible and eigenmodes almost completely coincide with linearly TE- and/or TM-polarized eigenmodes of the non-magnetic photonic crystal.
TM-TE hybridization and tunable refraction in magnetophotonic crystals
International Nuclear Information System (INIS)
Khanikaev, A.B.; Inoue, M.; Granovsky, A.B.
2006-01-01
In the present work we study the photonic band structure (PBS) and the polarization state of the Bloch eigenmodes of a two-dimensional magnetophotonic crystal (MPC) with square lattice formed from magneto-optically (MO) active cylinders. The refraction of light at the boundary of the MPC is analyzed. We found that both-the PBS and eigenmodes of the MPC-are most significantly altered by the MO activity in the vicinity of the degeneracies. For this case we demonstrated the possibility of an abrupt change in the propagation direction of light by the application of a magnetic field. For the Bloch wave vectors and frequencies corresponding to non-degenerate branches, the alteration of the PBS is shown to be negligible and eigenmodes almost completely coincide with linearly TE- and/or TM-polarized eigenmodes of the non-magnetic photonic crystal
Sensing characteristics of birefringent microstructured polymer optical fiber
DEFF Research Database (Denmark)
Szczurowski, Marcin K.; Frazao, Orlando; Baptista, J. M.
2011-01-01
We experimentally studied several sensing characteristics of a birefringent microstructured polymer optical fiber. The fiber exhibits a birefringence of the order 2×10-5 at 1.3 μm because of two small holes adjacent to the core. In this fiber, we measured spectral dependence of phase and group mo...
A Linear Birefringence Measurement Method for an Optical Fiber Current Sensor.
Xu, Shaoyi; Shao, Haiming; Li, Chuansheng; Xing, Fangfang; Wang, Yuqiao; Li, Wei
2017-07-03
In this work, a linear birefringence measurement method is proposed for an optical fiber current sensor (OFCS). First, the optical configuration of the measurement system is presented. Then, the elimination method of the effect of the azimuth angles between the sensing fiber and the two polarizers is demonstrated. Moreover, the relationship of the linear birefringence, the Faraday rotation angle and the final output is determined. On these bases, the multi-valued problem on the linear birefringence is simulated and its solution is illustrated when the linear birefringence is unknown. Finally, the experiments are conducted to prove the feasibility of the proposed method. When the numbers of turns of the sensing fiber in the OFCS are about 15, 19, 23, 27, 31, 35, and 39, the measured linear birefringence obtained by the proposed method are about 1.3577, 1.8425, 2.0983, 2.5914, 2.7891, 3.2003 and 3.5198 rad. Two typical methods provide the references for the proposed method. The proposed method is proven to be suitable for the linear birefringence measurement in the full range without the limitation that the linear birefringence must be smaller than π/2.
Highly Nonlinear and Birefringent Spiral Photonic Crystal Fiber
Directory of Open Access Journals (Sweden)
S. Revathi
2014-01-01
Full Text Available We propose and design a spiral photonic crystal fiber with elliptical air holes for achieving high birefringence, large nonlinearity, and negative dispersion. The structure is designed using chalcogenide glass (As2S3 for different ellipticity ratios of air holes in the cladding and the effect on various properties is observed. The proposed structure has birefringence of the order 10−2, nonlinearity of 26739.42 W−1 m−1, and dispersion of −1136.69 at 0.85 μm. An accurate numerical approach based on finite element method is used for the design and simulation of the structure. Due to high birefringence and negative dispersion, the proposed structure can be used for polarization control and dispersion compensation, respectively.
Birefringence in ordered (Al)GaInP
International Nuclear Information System (INIS)
Wirth, R.; Moritz, A.; Geng, C.; Scholz, F.; Hangleiter, A.
1997-01-01
We report on a way to examine the birefringence introduced by chemical ordering in (Al)GaInP using waveguide structures. We find that ordered (Al)GaInP is positively birefringent far below the band gap, while approaching the band gap it becomes negatively birefringent. The dispersion of the measured birefringence is compared with calculations that take into account the strongly anisotropic absorption at the band gap due to the splitting of the valence bands. We will show how the polarization state of light traveling along the [011] direction in chemically ordered (Al)GaInP waveguides is affected by the reduced crystal symmetry introduced by CuPt B -type ordering. Birefringence leads to a conversion of transverse electric (TE) and transverse magnetic (TM) polarized light within 60 μm. This can be understood due to new modes in the waveguide, the open-quotes supermodes,close quotes with an orientation tilted with respect to the TE/TM orientation. In the [01 bar 1] direction, the common TE/TM modes stay unchanged. With a simple theory of mode coupling, it is possible to understand the observed polarization behavior. A transfer-matrix method for anisotropic planar waveguides is used to achieve a more detailed analysis. Consequences and possibilities for applications are considered. copyright 1997 The American Physical Society
Hu, Haocheng; Zheng, Baozhong; Liu, Qingming; Li, Yang; Wu, Li; Gu, Shijie
2011-11-21
We design and demonstrate a birefringent Michelson interferometer based interleaver with ultra-low dispersion and low cost. The interleaver consists of polarizing beam splitters (PBS's) and quarter-wave plates and half-wave plates. The PBS's based Michelson interferometers provide the optical path difference for interference between the two orthogonal polarization components and the half-wave plates provide the birefringent needed to minimize ripple of output. The designed interleaver with two-stage interferometer in a 50 GHz channel spacing application exhibits a 0.5 dB passband and a 25 dB stopband both 27 GHz; a channel isolation higher than 35 dB and chromatic dispersion less than ±5 ps/nm within 0.5 dB passband; 1.3 dB insertion loss and 0.3 dB PDL; 0.04 GHz/°C thermal stability. Since all of the optical components can be optically bonded together, the device is robust and easy to be aligned, which reduces labor cost. © 2011 Optical Society of America
Chui, T. C. P.; Shao, M.; Redding, D.; Gursel, Y.; Boden, A.
1995-01-01
We discuss the effect of mirror birefringence in two optical schemes designed to detect the quantum-electrodynamics (QED) predictions of vacuum birefringence under the influence of a strong magnetic field, B. Both schemes make use of a high finesse Fabry-Perot cavity (F-P) to increase the average path length of the light in the magnetic field. The first scheme, which we called the frequency scheme, is based on measurement of the beat frequency of two orthogonal polarized laser beams in the cavity. We show that mirror birefringence contributes to the detection uncertainties in first order, resulting in a high susceptibility to small thermal disturbances. We estimate that an unreasonably high thermal stability of 10-9 K is required to resolve the effect to 0.1%. In the second scheme, which we called the polarization rotation scheme, laser polarized at 45 relative to the B field is injected into the cavity.
Birefringent hollow core fibers
DEFF Research Database (Denmark)
Roberts, John
2007-01-01
Hollow core photonic crystal fiber (HC-PCF), fabricated according to a nominally non-birefringent design, shows a degree of un-controlled birefringence or polarization mode dispersion far in excess of conventional non polarization maintaining fibers. This can degrade the output pulse in many...... applications, and places emphasis on the development of polarization maintaining (PM) HC-PCF. The polarization cross-coupling characteristics of PM HC-PCF are very different from those of conventional PM fibers. The former fibers have the advantage of suffering far less from stress-field fluctuations...... and an increased overlap between the polarization modes at the glass interfaces. The interplay between these effects leads to a wavelength for optimum polarization maintenance, lambda(PM), which is detuned from the wavelength of highest birefringence. By a suitable fiber design involving antiresonance of the core...
Two-dimensional electronic spectroscopy with birefringent wedges
Energy Technology Data Exchange (ETDEWEB)
Réhault, Julien; Maiuri, Margherita; Oriana, Aurelio; Cerullo, Giulio [IFN-CNR, Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)
2014-12-15
We present a simple experimental setup for performing two-dimensional (2D) electronic spectroscopy in the partially collinear pump-probe geometry. The setup uses a sequence of birefringent wedges to create and delay a pair of phase-locked, collinear pump pulses, with extremely high phase stability and reproducibility. Continuous delay scanning is possible without any active stabilization or position tracking, and allows to record rapidly and easily 2D spectra. The setup works over a broad spectral range from the ultraviolet to the near-IR, it is compatible with few-optical-cycle pulses and can be easily reconfigured to two-colour operation. A simple method for scattering suppression is also introduced. As a proof of principle, we present degenerate and two-color 2D spectra of the light-harvesting complex 1 of purple bacteria.
Directory of Open Access Journals (Sweden)
Maasa Nakano
2013-04-01
Full Text Available Micrometer order magnetophotonic crystals with periodic arranged metallic glass and oxide glass composite materials were fabricated by stereolithographic method to reflect electromagnetic waves in terahertz frequency ranges through Bragg diffraction. In the fabrication process, the photo sensitive acrylic resin paste mixed with micrometer sized metallic glass of Fe72B14.4Si9.6Nb4 and oxide glass of B2O3·Bi2O3 particles was spread on a metal substrate, and cross sectional images of ultra violet ray were exposed. Through the layer by layer stacking, micro lattice structures with a diamond type periodic arrangement were successfully formed. The composite structures could be obtained through the dewaxing and sintering process with the lower temperature under the transition point of metallic glass. Transmission spectra of the terahertz waves through the magnetophotonic crystals were measured by using a terahertz time domain spectroscopy.
Murzina, T. V.; Kim, E. M.; Kapra, R. V.; Moshnina, I. V.; Aktsipetrov, O. A.; Kurdyukov, D. A.; Kaplan, S. F.; Golubev, V. G.; Bader, M. A.; Marowsky, G.
2006-01-01
Three-dimensional magnetophotonic crystals (MPCs) based on artificial opals infiltrated by yttrium iron garnet (YIG) are fabricated and their structural, optical, and nonlinear optical properties are studied. The formation of the crystalline YIG inside the opal matrix is checked by x-ray analysis. Two templates are used for the infiltration by YIG: bare opals and those covered by a thin platinum film. Optical second-harmonic generation (SHG) technique is used to study the magnetization-induced nonlinear-optical properties of the composed MPCs. A high nonlinear magneto-optical Kerr effect in the SHG intensity is observed at the edge of the photonic band gap of the MPCs.
Electro-optical tunable birefringent filter
Levinton, Fred M [Princeton, NJ
2012-01-31
An electrically tunable Lyot type filter is a Lyot that include one or more filter elements. Each filter element may have a planar, solid crystal comprised of a material that exhibits birefringence and is electro-optically active. Transparent electrodes may be coated on each face of the crystal. An input linear light polarizer may be located on one side of the crystal and oriented at 45 degrees to the optical axis of the birefringent crystal. An output linear light polarizer may be located on the other side of the crystal and oriented at -45 degrees with respect to the optical axis of the birefringent crystal. When an electric voltage is applied between the electrodes, the retardation of the crystal changes and so does the spectral transmission of the optical filter.
Analysis and synthesis of one-dimensional magneto-photonic crystals using coupled mode theory
Energy Technology Data Exchange (ETDEWEB)
Saghirzadeh Darki, Behnam, E-mail: b.saghirzadeh@ec.iut.ac.ir; Nezhad, Abolghasem Zeidaabadi; Firouzeh, Zaker Hossein
2017-03-15
We utilize our previously developed temporal coupled mode approach to investigate the performance of one-dimensional magneto-photonic crystals (MPCs). We analytically demonstrate that a double-defect MPC provides adequate degrees of freedom to design a structure for arbitrary transmittance and Faraday rotation. By using our developed analytic approach along with the numerical transfer matrix method, we present a procedure for the synthesis of an MPC to generate any desired transmittance and Faraday rotation in possible ranges. However it is seen that only discrete values of transmittance and Faraday rotation are practically obtainable. To remedy this problem along with having short structures, we introduce a class of MPC heterostructures which are combinations of stacks with high and low optical contrast ratios.
Transient birefringence effects in electromagnetically induced transparency
International Nuclear Information System (INIS)
Parshkov, O M
2015-01-01
We report the results of numerical modelling of transient birefringence that arises as a result of electromagnetically induced transparency on degenerate quantum transitions between the states with J = 0, 1 and 2 in the presence of the Doppler broadening of spectral lines. It is shown that in the case of a linearly polarised control field, the effect of transient birefringence leads to a decay of the input circularly polarised probe pulse into separate linearly polarised pulses inside a medium. In the case of a circularly polarised control field, the effect of transient birefringence manifests itself in a decay of the input linearly polarised probe pulse into separate circularly polarised pulses. It is shown that the distance that a probe pulse has to pass in a medium before decaying into subpulses is considerably greater in the first case than in the second. The influence of the input probe pulse power and duration on the process of spatial separation into individual pulses inside a medium is studied. A qualitative analysis of the obtained results is presented. (nonlinear optical phenomena)
Crystallographic cut that maximizes of the birefringence in photorefractive crystals
Rueda-Parada, Jorge Enrique
2017-01-01
The electro-optical birefringence effect depends on the crystal type, cut crystal, applied electric field and the incidence direction of light on the principal crystal faces. It is presented a study of maximizing the birefringence in photorefractive crystals of cubic crystallographic symmetry, in terms of these three parameters. General analytical expressions for the birefringence were obtained, from which birefringence can be established for any type of cut. A new crystallographic cut was en...
Energy Technology Data Exchange (ETDEWEB)
Della Valle, Federico; Milotti, Edoardo [INFN, Trieste (Italy); Universita di Trieste, Dipt. di Fisica, Trieste (Italy); Ejlli, Aldo; Messineo, Giuseppe; Zavattini, Guido [INFN, Ferrara (Italy); Universita di Ferrara, Dipt. di Fisica e Scienze della Terra, Ferrara (Italy); Gastaldi, Ugo [INFN, Ferrara (Italy); Pengo, Ruggero; Ruoso, Giuseppe [INFN, Lab. Nazionale di Legnaro, Legnaro (Italy)
2016-01-15
Vacuum magnetic birefringence was predicted long time ago and is still lacking a direct experimental confirmation. Several experimental efforts are striving to reach this goal, and the sequence of results promises a success in the next few years. This measurement generally is accompanied by the search for hypothetical light particles that couple to two photons. The PVLAS experiment employs a sensitive polarimeter based on a high finesse Fabry-Perot cavity. In this paper we report on the latest experimental results of this experiment. The data are analysed taking into account the intrinsic birefringence of the dielectric mirrors of the cavity. Besides a new limit on the vacuum magnetic birefringence, the measurements also allow the model-independent exclusion of new regions in the parameter space of axion-like and milli-charged particles. In particular, these last limits hold also for all types of neutrinos, resulting in a laboratory limit on their charge. (orig.)
Detecting strain in birefringent materials using spectral polarimetry
Garner, Harold R. (Inventor); Ragucci, Anthony J. (Inventor); Cisar, Alan J. (Inventor); Huebschman, Michael L. (Inventor)
2010-01-01
A method, computer program product and system for analyzing multispectral images from a plurality of regions of birefringent material, such as a polymer film, using polarized light and a corresponding polar analyzer to identify differential strain in the birefringent material. For example, the birefringement material may be low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyvinylidene chloride, polyester, nylon, or cellophane film. Optionally, the method includes generating a real-time quantitative strain map.
Nonperturbative QED vacuum birefringence
Energy Technology Data Exchange (ETDEWEB)
Denisov, V.I.; Dolgaya, E.E.; Sokolov, V.A. [Physics Department, Moscow State University,Moscow, 119991 (Russian Federation)
2017-05-19
In this paper we represent nonperturbative calculation for one-loop Quantum Electrodynamics (QED) vacuum birefringence in presence of strong magnetic field. The dispersion relations for electromagnetic wave propagating in strong magnetic field point to retention of vacuum birefringence even in case when the field strength greatly exceeds Sauter-Schwinger limit. This gives a possibility to extend some predictions of perturbative QED such as electromagnetic waves delay in pulsars neighbourhood or wave polarization state changing (tested in PVLAS) to arbitrary magnetic field values. Such expansion is especially important in astrophysics because magnetic fields of some pulsars and magnetars greatly exceed quantum magnetic field limit, so the estimates of perturbative QED effects in this case require clarification.
Sperm head's birefringence: a new criterion for sperm selection.
Gianaroli, Luca; Magli, M Cristina; Collodel, Giulia; Moretti, Elena; Ferraretti, Anna P; Baccetti, Baccio
2008-07-01
To investigate the characteristics of birefringence in human sperm heads and apply polarization microscopy for sperm selection at intracytoplasmic sperm injection (ICSI). Prospective randomized study. Reproductive Medicine Unit, Società Italiana Studi Medicina della Riproduzione, Bologna, Italy. A total of 112 male patients had birefringent sperm selected for ICSI (study group). The clinical outcome was compared with that obtained in 119 couples who underwent a conventional ICSI cycle (control group). The proportion of birefringent spermatozoa was evaluated before and after treatment in relation to the sperm sample quality. Embryo development and clinical outcome in the study group were compared with those in the controls. Proportion of birefringent sperm heads, rates of fertilization, cleavage, pregnancy, implantation, and ongoing implantation. The proportion of birefringent spermatozoa was significantly higher in normospermic samples when compared with oligoasthenoteratospermic samples with no progressive motility and testicular sperm extraction samples. Although fertilization and cleavage rates did not differ between the study and control groups, in the most severe male factor condition (oligoasthenoteratospermic with no progressive motility and testicular sperm extraction), the rates of clinical pregnancy, ongoing pregnancy, and implantation were significantly higher in the study group versus the controls. The analysis of birefringence in the sperm head could represent both a diagnostic tool and a novel method for sperm selection.
The Study of Birefringent Homogenous Medium with Geometric Phase
International Nuclear Information System (INIS)
Banerjee, Dipti
2010-12-01
The property of linear and circular birefringence at each point of the optical medium has been evaluated here from differential matrix N using the Jones calculus. This matrix lies on the OAM sphere for l = 1 orbital angular momentum. The geometric phase is developed by twisting the medium uniformly about the direction of propagation of the light ray. The circular birefringence of the medium, is visualized through the solid angle and the angular twist per unit thickness of the medium, k, that is equivalent to the topological charge of the optical element. (author)
A note on the birefringence angle estimation in CMB data analysis
Energy Technology Data Exchange (ETDEWEB)
Gruppuso, A. [INAF, Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via P. Gobetti 101, I-40129 Bologna (Italy); Maggio, G. [INAF, Osservatorio Astronomico di Trieste, Via G.B. Tiepolo 11, Trieste (Italy); Molinari, D.; Natoli, P., E-mail: gruppuso@iasbo.inaf.it, E-mail: maggio@oats.inaf.it, E-mail: molinari@iasfbo.inaf.it, E-mail: ntlpla@unife.it [Dipartimento di Fisica e Scienze della Terra and INFN, Università degli Studi di Ferrara, Via Saragat 1, I-44100 Ferrara (Italy)
2016-05-01
Parity violating physics beyond the standard model of particle physics induces a rotation of the linear polarization of photons. This effect, also known as cosmological birefringence (CB), can be tested with the observations of the cosmic microwave background (CMB) anisotropies which are linearly polarized at the level of 5–10%. In particular CB produces non-null CMB cross correlations between temperature and B mode-polarization, and between E- and B-mode polarization. Here we study the properties of the so called D-estimators, often used to constrain such an effect. After deriving the framework of both frequentist and Bayesian analysis, we discuss the interplay between birefringence and weak-lensing, which, albeit parity conserving, modifies pre-existing TB and EB cross correlation.
Note: Ultra-low birefringence dodecagonal vacuum glass cell
Energy Technology Data Exchange (ETDEWEB)
Brakhane, Stefan, E-mail: brakhane@iap.uni-bonn.de; Alt, Wolfgang; Meschede, Dieter; Robens, Carsten; Moon, Geol; Alberti, Andrea [Institut für Angewandte Physik, Universität Bonn, Wegelerstr. 8, D-53115 Bonn (Germany)
2015-12-15
We report on an ultra-low birefringence dodecagonal glass cell for ultra-high vacuum applications. The epoxy-bonded trapezoidal windows of the cell are made of SF57 glass, which exhibits a very low stress-induced birefringence. We characterize the birefringence Δn of each window with the cell under vacuum conditions, obtaining values around 10{sup −8}. After baking the cell at 150 °C, we reach a pressure below 10{sup −10} mbar. In addition, each window is antireflection coated on both sides, which is highly desirable for quantum optics experiments and precision measurements.
Linear birefringence and optical ativity in a magnetized plasma
International Nuclear Information System (INIS)
Vuolo, J.H.; Galvao, R.M.O.
1982-02-01
Linear birefringence and optical activity are considered separately to electromagnetic wave propagation in magnetized cold plasma, using frequency approximation much bigger than plasma frequency. It's showen that in some interesting cases, those phenomena could be independents. Explicit expressions are obtained for refraction indices to linear birefringency and optical activity. The correspondents indices attenuation aRe obtained in first orden of attenuation. It's showen that the characteristic states for linear dichroism coincide with the characteristic states for linear birefringence. The characteristic states for elliptic dichroism are obtained. (M.A.F.) [pt
First results from the new PVLAS apparatus: A new limit on vacuum magnetic birefringence
Della Valle, F.; Milotti, E.; Ejlli, A.; Messineo, G.; Piemontese, L.; Zavattini, G.; Gastaldi, U.; Pengo, R.; Ruoso, G.
2014-11-01
Several groups are carrying out experiments to observe and measure vacuum magnetic birefringence, predicted by quantum electrodynamics (QED). We have started running the new PVLAS apparatus installed in Ferrara, Italy, and have measured a noise floor value for the unitary field magnetic birefringence of vacuum Δ nu(vac )=(4 ±20 )×1 0-23 T-2 (the error represents a 1 σ deviation). This measurement is compatible with zero and hence represents a new limit on vacuum magnetic birefringence deriving from nonlinear electrodynamics. This result reduces to a factor of 50 the gap to be overcome to measure for the first time the value of Δ nu(vac ,QED ) predicted by QED: Δ nu(vac ,QED )=4 ×10-24 T-2 . These birefringence measurements also yield improved model-independent bounds on the coupling constant of axion-like particles to two photons, for masses greater than 1 meV, along with a factor-2 improvement of the fractional charge limit on millicharged particles (fermions and scalars), including neutrinos.
Anomalously temperature-independent birefringence in biaxial optical crystals
International Nuclear Information System (INIS)
Grechin, Sergei G; Dmitriev, Valentin G; Dyakov, Vladimir A; Pryalkin, Vladimir I
2000-01-01
Temperature-independent birefringence in a biaxial crystal was predicted theoretically and observed experimentally for the first time. The width of the plot against temperature (the range corresponding to the temperature independence of the birefringence) at a fundamental radiation wavelength of 632.8 nm in a KTP crystal 5.9 mm long was more than 160 0 C. (letters to the editor)
Controlling material birefringence in sapphire via self-assembled, sub-wavelength defects
Singh, Astha; Sharma, Geeta; Ranjan, Neeraj; Mittholiya, Kshitij; Bhatnagar, Anuj; Singh, B. P.; Mathur, Deepak; Vasa, Parinda
2018-02-01
Birefringence is the optical property of a material having a refractive index that depends on the polarization and propagation direction of light. Generally, this is an intrinsic optical property of a material and cannot be altered. Here, we report a novel technique—direct laser writing—that enables us to control the natural, material birefringence of sapphire over a broad range of wavelengths. The broadband form birefringence originating from self-assembled, periodic array of sub-wavelength (˜ 50-200 nm) defects created by laser writing, can enhance, suppress or maintain the material birefringence of sapphire without affecting its transparency range in visible or its surface quality.
Birefringence Polarimeter Using Dual LiNbO3 Electrooptic Crystal Modulators
Saitou, Takeshi; Nurdin Bin, Muhammad; Kowa, Hiroyuki; Umeda, Norihiro; Takizawa, Kuniharu; Kondoh, Eiichi; Jin, Lianhua
2012-08-01
A birefringence polarimeter that uses dual LiNbO3 electrooptic crystal modulators operating at a frequency ratio of 4:1 is described. The significance of this polarimeter is that the birefringent parameters of a sample are obtained only from the modulated polarization status. The measurement, therefore, avoids depolarization effects resulting from the sample itself and the rest of the optical system. The high speed and accuracy of this polarimeter are shown by measurements using a quarter-wave plate, a Babinet-Soleil compensator, and a phase modulator.
Genetic optimization of magneto-optic Kerr effect in lossy cavity-type magnetophotonic crystals
Energy Technology Data Exchange (ETDEWEB)
Ghanaatshoar, M., E-mail: m-ghanaat@cc.sbu.ac.i [Laser and Plasma Research Institute, Shahid Beheshti University, G.C., Evin 1983963113, Tehran (Iran, Islamic Republic of); Alisafaee, H. [Laser and Plasma Research Institute, Shahid Beheshti University, G.C., Evin 1983963113, Tehran (Iran, Islamic Republic of)
2011-07-15
We have demonstrated an optimization approach in order to obtain desired magnetophotonic crystals (MPCs) composed of a lossy magnetic layer (TbFeCo) placed within a multilayer structure. The approach is an amalgamation between a 4x4 transfer matrix method and a genetic algorithm. Our objective is to enhance the magneto-optic Kerr effect of TbFeCo at short visible wavelength of 405 nm. Through the optimization approach, MPC structures are found meeting definite criteria on the amount of reflectivity and Kerr rotation. The resulting structures are fitted more than 99.9% to optimization criteria. Computation of the internal electric field distribution shows energy localization in the vicinity of the magnetic layer, which is responsible for increased light-matter interaction and consequent enhanced magneto-optic Kerr effect. Versatility of our approach is also exhibited by examining and optimizing several MPC structures. - Research highlights: Structures comprising a highly absorptive TbFeCo layer are designed to work for data storage applications at 405 nm. Optimization algorithm resulted in structures fitted 99.9% to design criteria. More than 10 structures are found exhibiting magneto-optical response of about 1{sup o} rotation and 20% reflection. The ratio of the Kerr rotation to the Kerr ellipticity is enhanced by a factor of 30.
Angular tuning of the magnetic birefringence in rippled cobalt films
Energy Technology Data Exchange (ETDEWEB)
Arranz, Miguel A., E-mail: MiguelAngel.Arranz@uclm.es [Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, Avda. Camilo J. Cela 10, 13071 Ciudad Real (Spain); Colino, José M. [Instituto de Nanociencia, Nanotecnología y Materiales Moleculares, Universidad de Castilla-La Mancha, Campus de la Fábrica de Armas, 45071 Toledo (Spain)
2015-06-22
We report the measurement of magnetically induced birefringence in rippled Co films. For this purpose, the magneto-optical properties of ion beam eroded ferromagnetic films were studied using Kerr magnetometry and magnetic birefringence in the transmitted light intensity. Upon sufficient ion sculpting, these ripple surface nanostructures developed a defined uniaxial anisotropy in the in-plane magnetization, finely tuning the magnetic birefringence effect. We have studied its dependence on the relative orientation between the ripple direction and the magnetic field, and found this effect to be dramatically correlated with the capability to neatly distinguish the mechanisms for the in-plane magnetization reversal, i.e., rotation and nucleation. This double refraction corresponds univocally to the two magnetization axes, parallel and perpendicular to the ripples direction. We have also observed that tuned birefringence in stack assemblies of rippled Co films, which enables us to technically manipulate the number and direction of refraction axes.
Angular tuning of the magnetic birefringence in rippled cobalt films
International Nuclear Information System (INIS)
Arranz, Miguel A.; Colino, José M.
2015-01-01
We report the measurement of magnetically induced birefringence in rippled Co films. For this purpose, the magneto-optical properties of ion beam eroded ferromagnetic films were studied using Kerr magnetometry and magnetic birefringence in the transmitted light intensity. Upon sufficient ion sculpting, these ripple surface nanostructures developed a defined uniaxial anisotropy in the in-plane magnetization, finely tuning the magnetic birefringence effect. We have studied its dependence on the relative orientation between the ripple direction and the magnetic field, and found this effect to be dramatically correlated with the capability to neatly distinguish the mechanisms for the in-plane magnetization reversal, i.e., rotation and nucleation. This double refraction corresponds univocally to the two magnetization axes, parallel and perpendicular to the ripples direction. We have also observed that tuned birefringence in stack assemblies of rippled Co films, which enables us to technically manipulate the number and direction of refraction axes
Birefringent phononic structures
Directory of Open Access Journals (Sweden)
I. E. Psarobas
2014-12-01
Full Text Available Within the framework of elastic anisotropy, caused in a phononic crystal due to low crystallographic symmetry, we adopt a model structure, already introduced in the case of photonic metamaterials, and by analogy, we study the effect of birefringence and acoustical activity in a phononic crystal. In particular, we investigate its low-frequency behavior and comment on the factors which determine chirality by reference to this model.
Kasaragod, Deepa; Sugiyama, Satoshi; Ikuno, Yasushi; Alonso-Caneiro, David; Yamanari, Masahiro; Fukuda, Shinichi; Oshika, Tetsuro; Hong, Young-Joo; Li, En; Makita, Shuichi; Miura, Masahiro; Yasuno, Yoshiaki
2016-03-01
Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT that contrasts the polarization properties of tissues. It has been applied to ophthalmology, cardiology, etc. Proper quantitative imaging is required for a widespread clinical utility. However, the conventional method of averaging to improve the signal to noise ratio (SNR) and the contrast of the phase retardation (or birefringence) images introduce a noise bias offset from the true value. This bias reduces the effectiveness of birefringence contrast for a quantitative study. Although coherent averaging of Jones matrix tomography has been widely utilized and has improved the image quality, the fundamental limitation of nonlinear dependency of phase retardation and birefringence to the SNR was not overcome. So the birefringence obtained by PS-OCT was still not accurate for a quantitative imaging. The nonlinear effect of SNR to phase retardation and birefringence measurement was previously formulated in detail for a Jones matrix OCT (JM-OCT) [1]. Based on this, we had developed a maximum a-posteriori (MAP) estimator and quantitative birefringence imaging was demonstrated [2]. However, this first version of estimator had a theoretical shortcoming. It did not take into account the stochastic nature of SNR of OCT signal. In this paper, we present an improved version of the MAP estimator which takes into account the stochastic property of SNR. This estimator uses a probability distribution function (PDF) of true local retardation, which is proportional to birefringence, under a specific set of measurements of the birefringence and SNR. The PDF was pre-computed by a Monte-Carlo (MC) simulation based on the mathematical model of JM-OCT before the measurement. A comparison between this new MAP estimator, our previous MAP estimator [2], and the standard mean estimator is presented. The comparisons are performed both by numerical simulation and in vivo measurements of anterior and
Large tuning of birefringence in two strip silicon waveguides via optomechanical motion.
Ma, Jing; Povinelli, Michelle L
2009-09-28
We present an optomechanical method to tune phase and group birefringence in parallel silicon strip waveguides. We first calculate the deformation of suspended, parallel strip waveguides due to optical forces. We optimize the frequency and polarization of the pump light to obtain a 9 nm deformation for an optical power of 20 mW. Widely tunable phase and group birefringence can be achieved by varying the pump power, with maximum values of 0.026 and 0.13, respectively. The giant phase birefringence allows linear to circular polarization conversion within 30 microm for a pump power of 67 mW. The group birefringence gives a tunable differential group delay of 6fs between orthogonal polarizations. We also evaluate the tuning performance of waveguides with different cross sections.
International Nuclear Information System (INIS)
Gan, Ma; Kushtal, Gi; Skomorovsky, Vi; Domyshev, Gn; Sadokhin, Vp
2006-01-01
The finishing of birefringent plates consists of two processes: polishing and evaluation of a surface, which have been performed separately till now. The purpose of this work is achieving of high accuracy of the evaluation and machining of the plane-parallel plates from birefringent crystals, in particular of crystal plates of birefringent filters during their finishing. The developed process combines evaluation and polishing in an interactive way. We have found modes of treatment, shape of polisher, have designed interferometer, with a mirror arranged in polisher. Visual checking of optical thickness comparatively with reference plate was carried out using the interference fringes of equal birefringence, and checking of an optical wedge - by interference rings of an equal inclination. The automated processing of TV camera interference fringes was impossible, because of gaps of interference fringes on polishing cells above the mirror. Therefore a special software was developed for processing of a complex fringe pattern interferogram. Software FastInterf uses furrier analysis technique which allows to process an interferogram with multiply gaps. Interferograms are registered by a high resolution TV camera (1280 x1024). Automatic processing of a fringe interferogram using FastInterf software takes less then one second. The influence of gaps is excluded, and the flat field is taken into account. Software provides full 3D surface and wavefront maps. Aberration analysis of a wavefront gives information on thickness of a plate comparatively with a reference one, optical wedge of plate and azimuth of an inclination of wave front. Moreover, software provides a control of surface quality. The measuring device, features of the software are described and process of interferometric evaluation during polishing is illustrated
Quantification of birefringence readily measures the level of muscle damage in zebrafish
Energy Technology Data Exchange (ETDEWEB)
Berger, Joachim, E-mail: Joachim.Berger@Monash.edu [Australian Regenerative Medicine Institute, EMBL Australia, Monash University, Clayton (Australia); Sztal, Tamar; Currie, Peter D. [Australian Regenerative Medicine Institute, EMBL Australia, Monash University, Clayton (Australia)
2012-07-13
Highlights: Black-Right-Pointing-Pointer Report of an unbiased quantification of the birefringence of muscle of fish larvae. Black-Right-Pointing-Pointer Quantification method readily identifies level of overall muscle damage. Black-Right-Pointing-Pointer Compare zebrafish muscle mutants for level of phenotype severity. Black-Right-Pointing-Pointer Proposed tool to survey treatments that aim to ameliorate muscular dystrophy. -- Abstract: Muscular dystrophies are a group of genetic disorders that progressively weaken and degenerate muscle. Many zebrafish models for human muscular dystrophies have been generated and analysed, including dystrophin-deficient zebrafish mutants dmd that model Duchenne Muscular Dystrophy. Under polarised light the zebrafish muscle can be detected as a bright area in an otherwise dark background. This light effect, called birefringence, results from the diffraction of polarised light through the pseudo-crystalline array of the muscle sarcomeres. Muscle damage, as seen in zebrafish models for muscular dystrophies, can readily be detected by a reduction in the birefringence. Therefore, birefringence is a very sensitive indicator of overall muscle integrity within larval zebrafish. Unbiased documentation of the birefringence followed by densitometric measurement enables the quantification of the birefringence of zebrafish larvae. Thereby, the overall level of muscle integrity can be detected, allowing the identification and categorisation of zebrafish muscle mutants. In addition, we propose that the establish protocol can be used to analyse treatments aimed at ameliorating dystrophic zebrafish models.
Quantification of birefringence readily measures the level of muscle damage in zebrafish
International Nuclear Information System (INIS)
Berger, Joachim; Sztal, Tamar; Currie, Peter D.
2012-01-01
Highlights: ► Report of an unbiased quantification of the birefringence of muscle of fish larvae. ► Quantification method readily identifies level of overall muscle damage. ► Compare zebrafish muscle mutants for level of phenotype severity. ► Proposed tool to survey treatments that aim to ameliorate muscular dystrophy. -- Abstract: Muscular dystrophies are a group of genetic disorders that progressively weaken and degenerate muscle. Many zebrafish models for human muscular dystrophies have been generated and analysed, including dystrophin-deficient zebrafish mutants dmd that model Duchenne Muscular Dystrophy. Under polarised light the zebrafish muscle can be detected as a bright area in an otherwise dark background. This light effect, called birefringence, results from the diffraction of polarised light through the pseudo-crystalline array of the muscle sarcomeres. Muscle damage, as seen in zebrafish models for muscular dystrophies, can readily be detected by a reduction in the birefringence. Therefore, birefringence is a very sensitive indicator of overall muscle integrity within larval zebrafish. Unbiased documentation of the birefringence followed by densitometric measurement enables the quantification of the birefringence of zebrafish larvae. Thereby, the overall level of muscle integrity can be detected, allowing the identification and categorisation of zebrafish muscle mutants. In addition, we propose that the establish protocol can be used to analyse treatments aimed at ameliorating dystrophic zebrafish models.
Ultraviolet-induced birefringence in hydrogen-loaded optical fiber
DEFF Research Database (Denmark)
Canning, John; Deyerl, Hans-Jürgen; Sørensen, Henrik Rokkjær
2005-01-01
for the role of hydrogen and deuterium in the UV-induced process. Previous arguments for the origins are systematically ruled out by reviewing existing literature. We note that the birefringence is made up of at least two components with different thermal stabilities, one consistent simply with molecular...... hydrogen being present in the system. Overall the birefringence, by deduction, is associated with anisotropy in hydrogen reactions within the fiber. As a result they lead, through known mechanisms of dilation in glass, to anisotropic stress relaxation that can be annealed out, with or without hydrogen...
Birefringence Optical Feedback with a Folded Cavity in HeNe Laser
International Nuclear Information System (INIS)
Wu Yun; Tan Yi-Dong
2013-01-01
The birefringence optical feedback with a folded cavity in HeNe laser is investigated. A theory model based on the equivalent cavity of the Fabry—Perot interferometer is presented. The phase difference between the two intensities in birefringence feedback is twice the retardation of the wave plate. The phase difference is invariable when the length of the feedback cavity changes. With the adoption of a cube corner prism (CCP) to form a folded cavity, the fringe frequency is doubled, and the resolution of the displacement sensor based on birefringence optical feedback with a folded cavity is improved. A resistance chain of 5-fold subdivision and 4-fold logic subdivision is used as further subdivision. The resolution of λ/80 is obtained eventually; for 632.8 nm HeNe laser it is 7.91 nm. The displacement sensor based on birefringence optical feedback with a folded cavity is simple and of high resolution, large measurement range, low cost, and is of great application potential in industry
Hynninen, Ville; Hietala, Sami; McKee, Jason Robert; Murtomäki, Lasse; Rojas, Orlando J; Ikkala, Olli; Nonappa, Nonappa
2018-05-07
We show that composite hydrogels comprising methyl cellulose (MC) and cellulose nanocrystal (CNC) colloidal rods display a reversible and enhanced rheological storage modulus and optical birefringence upon heating, i.e., inverse thermoreversibility. Dynamic rheology, quantitative polarized optical microscopy (POM), isothermal titration calorimetry (ITC), circular dichroism (CD), and scanning and transmission electron microscopy (SEM and TEM) were used for characterization. The concentration of CNC in aqueous media was varied up to 3.5 wt % (i.e, keeping the concentration below the critical aq. concentration) while maintaining the MC aq. concentration at 1.0 wt %. At 20 °C, MC/CNC underwent gelation upon passing the CNC concentration of 1.5 wt %. At this point the storage modulus (G´) reached a plateau, and the birefringence underwent a stepwise increase, thus suggesting a percolative phenomenon. The storage modulus (G´) of the composite gels was an order of magnitude higher at 60 °C compared to that at 20 °C. ITC results suggested that at 60 °C, the CNC rods were entropically driven to interact with MC chains, which according to recent studies, collapse at this temperature into ring-like, colloidal-scale persistent fibrils with hollow cross-section. Consequently, the increased requirement for space and mutual alignment of components results in enhanced birefringence. At room temperature, ITC shows enthalpic binding between CNCs and MC with the latter comprising an aqueous, molecularly dispersed polymer chains that lead to looser and less birefringent material. TEM, SEM, and CD indicated CNC chiral fragments within MC/CNC composite gel. Thus, their space-filling, thermoreversible assembly within the MC network can be used to tune the rheological properties and to access liquid crystalline properties at low CNC concentrations.
Cosmological birefringence constraints from CMB and astrophysical polarization data
Energy Technology Data Exchange (ETDEWEB)
Galaverni, M. [Studio Teologico Interdiocesano, V.le Timavo 93, Reggio Emilia, 42121 Italy (Italy); Gubitosi, G. [Dipartimento di Fisica and sez. Roma1 INFN, Università di Roma ' La Sapienza' , P.le A. Moro 2, Rome, 00185 Italy (Italy); Paci, F. [SISSA, Scuola Internazionale Superiore di Studi Avanzati, Via Bonomea 265, Trieste, 34136 Italy (Italy); Finelli, F., E-mail: matteo.galaverni@gmail.com, E-mail: giulia.gubitosi@imperial.ac.uk, E-mail: fpaci@sissa.it, E-mail: finelli@iasfbo.inaf.it [INAF-IASF Bologna, via Gobetti 101, Bologna, I-40129 Italy (Italy)
2015-08-01
Cosmological birefringence is a rotation of the polarization plane of photons coming from sources of astrophysical and cosmological origin. The rotation can also depend on the energy of the photons and not only on the distance of the source and on the cosmological evolution of the underlying theoretical model. In this work, we constrain few selected models for cosmological birefringence, combining CMB and astrophysical data at radio, optical, X and γ wavelengths, taking into account the specific energy and distance dependences.
Energy Technology Data Exchange (ETDEWEB)
Raposo, Maria, E-mail: mfr@fct.unl.pt; Monteiro Timóteo, Ana Rita; Ribeiro, Paulo A. [CEFITEC, Departamento de Física, Faculdade de Ciências e Tecnologia, UNL, Campus de Caparica, 2829-516 Caparica (Portugal); Ferreira, Quirina [CEFITEC, Departamento de Física, Faculdade de Ciências e Tecnologia, UNL, Campus de Caparica, 2829-516 Caparica (Portugal); Instituto de Telecomunicações, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal); Botelho do Rego, Ana Maria [Centro de Química-Física Molecular and IN, Complexo Interdisciplinar, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisboa (Portugal)
2015-09-21
Photo induced birefringent materials can be used to develop optical and conversion energy devices, and consequently, the study of the variables that influences the creation and relaxation of birefringence should be carefully analyzed. In this work, the parameters of birefringence creation and relaxation kinetics curves obtained on layer-by-layer (LBL) films, prepared from azo-polyectrolyte poly[1-[4-(3-carboxy-4 hydroxyphenylazo) benzene sulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and poly(allylamine hydrochloride)(PAH), are related with the presence of counterions and the degree of ionization of the polyelectrolytes. Those kinetics curves obtained on PAH/PAZO LBL films, prepared from PAH solutions with different pHs and maintaining the pH of PAZO solution constant at pH = 9, were analyzed taking into account the films composition which was characterized by X-ray photoelectron spectroscopy. The creation and relaxation birefringence curves are justified by two processes: one associated to local mobility of the azobenzene with a characteristic time 30 s and intensity constant and other associated with polymeric chains mobility with the characteristic time and intensity decreasing with pH. These results allow us to conclude that the birefringence creation process, associated to local mobility of azobenzenes is independent of the degree of ionization and of number of counterions or co-ions present while the birefringence creation process associated to mobility of chains have its characteristic time and intensity dependent of both degree of ionization and number of counterions. The birefringence relaxation processes are dependent of the degree of ionization. The analysis of the films composition revealed, in addition, the presence of a protonated secondary or tertiary amine revealing that PAZO may have positive charges and consequently a zwitterionic behavior.
International Nuclear Information System (INIS)
Raposo, Maria; Monteiro Timóteo, Ana Rita; Ribeiro, Paulo A.; Ferreira, Quirina; Botelho do Rego, Ana Maria
2015-01-01
Photo induced birefringent materials can be used to develop optical and conversion energy devices, and consequently, the study of the variables that influences the creation and relaxation of birefringence should be carefully analyzed. In this work, the parameters of birefringence creation and relaxation kinetics curves obtained on layer-by-layer (LBL) films, prepared from azo-polyectrolyte poly[1-[4-(3-carboxy-4 hydroxyphenylazo) benzene sulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and poly(allylamine hydrochloride)(PAH), are related with the presence of counterions and the degree of ionization of the polyelectrolytes. Those kinetics curves obtained on PAH/PAZO LBL films, prepared from PAH solutions with different pHs and maintaining the pH of PAZO solution constant at pH = 9, were analyzed taking into account the films composition which was characterized by X-ray photoelectron spectroscopy. The creation and relaxation birefringence curves are justified by two processes: one associated to local mobility of the azobenzene with a characteristic time 30 s and intensity constant and other associated with polymeric chains mobility with the characteristic time and intensity decreasing with pH. These results allow us to conclude that the birefringence creation process, associated to local mobility of azobenzenes is independent of the degree of ionization and of number of counterions or co-ions present while the birefringence creation process associated to mobility of chains have its characteristic time and intensity dependent of both degree of ionization and number of counterions. The birefringence relaxation processes are dependent of the degree of ionization. The analysis of the films composition revealed, in addition, the presence of a protonated secondary or tertiary amine revealing that PAZO may have positive charges and consequently a zwitterionic behavior
Birefringence and dichroism of poly(vinyl-alcohol) foils containing phthalazinium ylids
Rogojanu, Alina; Dascalu, Carmen Felicia; Zelinschi, Beatrice Carmen; Caprosu, Maria; Dorohoi, Dana Ortansa
2011-10-01
Pure and colored with phthalazinium ylids poly(vinyl-alcohol) (PVA) foils were stretched under gentile heating. The birefringence of the thin foils was determined with a Babinet compensator standardized for yellow radiation of a Sodium lamp. The determined birefringence of the colored PVA foils is higher than that of the pure PVA foils. This fact indicates that the phthalazinium ylids facilitate the increase in the anisotropy of the stretched foils. The visible absorption electronic band of phthalazinium ylids was used to estimate the dichroic ratio and the degree of order of the ylid molecules in the stretched PVA foils. An increase in dichroism and birefringence with the degree of stretching has been evidenced for uncolored and colored PVA foils.
Differential diagnosis of periapical cyst using collagen birefringence pattern of the cyst wall
Directory of Open Access Journals (Sweden)
Hyo Jin Ji
2017-05-01
Full Text Available Objectives Periapical lesions, including periapical cyst (PC, periapical granuloma (PG, and periapical abscess (PA, are frequently affected by chemical/physical damage during root canal treatment or severe bacterial infection, and thus, the differential diagnosis of periapical lesions may be difficult due to the presence of severe inflammatory reaction. The aim of this study was to make differential diagnosis among PC, PG, and PA under polarizing microscope. Materials and Methods The collagen birefringence patterns of 319 cases of PC (n = 122, PG (n = 158, and PA (n = 39 obtained using a polarizing microscope were compared. In addition, 6 cases of periodontal fibroma (PF were used as positive controls. Results Collagen birefringence was condensed with a thick, linear band-like pattern in PC, but was short and irregularly scattered in PG, and scarce or absent in PA. PF showed intense collagen birefringence with a short, palisading pattern but no continuous band-like pattern. The linear band-like birefringence in PC was ascribed to pre-existing expansile tensile stress of the cyst wall. Conclusions In this study all PCs (n = 122 were distinguishable from PGs and PAs by their characteristic birefringence, despite the absence of lining epithelium (n = 20. Therefore, the authors suggest that the presence of linear band-like collagen birefringence of the cyst wall aids the diagnostic differentiation of PC from PG and PA.
Differential diagnosis of periapical cyst using collagen birefringence pattern of the cyst wall.
Ji, Hyo Jin; Park, Se-Hee; Cho, Kyung-Mo; Lee, Suk Keun; Kim, Jin Woo
2017-05-01
Periapical lesions, including periapical cyst (PC), periapical granuloma (PG), and periapical abscess (PA), are frequently affected by chemical/physical damage during root canal treatment or severe bacterial infection, and thus, the differential diagnosis of periapical lesions may be difficult due to the presence of severe inflammatory reaction. The aim of this study was to make differential diagnosis among PC, PG, and PA under polarizing microscope. The collagen birefringence patterns of 319 cases of PC ( n = 122), PG ( n = 158), and PA ( n = 39) obtained using a polarizing microscope were compared. In addition, 6 cases of periodontal fibroma (PF) were used as positive controls. Collagen birefringence was condensed with a thick, linear band-like pattern in PC, but was short and irregularly scattered in PG, and scarce or absent in PA. PF showed intense collagen birefringence with a short, palisading pattern but no continuous band-like pattern. The linear band-like birefringence in PC was ascribed to pre-existing expansile tensile stress of the cyst wall. In this study all PCs ( n = 122) were distinguishable from PGs and PAs by their characteristic birefringence, despite the absence of lining epithelium ( n = 20). Therefore, the authors suggest that the presence of linear band-like collagen birefringence of the cyst wall aids the diagnostic differentiation of PC from PG and PA.
International Nuclear Information System (INIS)
Koplow, Jeffrey P.; Goldberg, Lew; Moeller, Robert P.; Kliner, Dahv A. V.
2000-01-01
We report a new approach to obtaining linear-polarization operation of a rare-earth-doped fiber amplifier in which the gain fiber is coiled under tension to induce birefringence. We demonstrated this method by constructing an Er/Yb-doped, double-clad, single-mode fiber amplifier with an output power of 530 mW and a polarization extinction ratio of >17 dB (when seeded with linearly polarized light) at a wavelength of ∼1.5 μm . The technique is achromatic, permits single- or multiple-pass operation of the amplifier, requires no additional components in the optical path, leaves the fiber ends unobstructed, and is inexpensive to implement. (c) 2000 Optical Society of America
Relationships between birefringence and mineral content in artificial caries lesions of enamel.
Theuns, H.M.; Shellis, R.P.; Groeneveld, A.; Dijk, J.W. van; Poole, D.F.
1993-01-01
The microradiographic mineral content and birefringence in water and Thoulet's solution were measured at selected points in sections of caries-like lesions. Birefringence was not related to mineral content in sound superficial enamel immersed in Thoulet's solution or in the lesion body immersed in
Extremely High-Birefringent Asymmetric Slotted-Core Photonic Crystal Fiber in THz Regime
DEFF Research Database (Denmark)
Islam, Raonaqul; Habib, Selim; Hasanuzzaman, G.K.M.
2015-01-01
We present a thorough numerical analysis of a highly birefringent slotted porous-core circular photonic crystal fiber (PCF) for terahertz (THz) wave guidance. The slot shaped air-holes break the symmetry of the porous-core which offers a very high birefringence whereas the compact geometry of the...
Constraints on cosmological birefringence from PLANCK and Bicep2/Keck data
Energy Technology Data Exchange (ETDEWEB)
Gruppuso, A. [INAF-IASF Bologna, Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, Istituto Nazionale di Astrofisica, via Gobetti 101, I-40129 Bologna (Italy); Gerbino, M.; Pagano, L.; Melchiorri, A. [Dipartimento di Fisica and INFN, Università di Roma ' ' La Sapienza' ' , P.le Aldo Moro 2, 00185, Rome (Italy); Natoli, P.; Mandolesi, N.; Molinari, D., E-mail: gruppuso@iasbo.inaf.it, E-mail: martina.gerbino@roma1.infn.it, E-mail: ntlpla@unife.it, E-mail: luca.pagano@roma1.infn.it, E-mail: mandolesi@iasfbo.inaf.it, E-mail: alessandro.melchiorri@roma1.infn.it, E-mail: molinari@iasfbo.inaf.it [Dipartimento di Fisica e Scienze della Terra and INFN, Università degli Studi di Ferrara, Via Saragat 1, I-44100 Ferrara (Italy)
2016-06-01
The polarization of cosmic microwave background (CMB) can be used to constrain cosmological birefringence, the rotation of the linear polarization of CMB photons potentially induced by parity violating physics beyond the standard model. This effect produces non-null CMB cross correlations between temperature and B mode-polarization, and between E- and B-mode polarization. Both cross-correlations are otherwise null in the standard cosmological model. We use the recently released 2015 PLANCK likelihood in combination with the Bicep2/Keck/Planck (BKP) likelihood to constrain the birefringence angle α. Our findings, that are compatible with no detection, read α = 0.0° ± 1.3° (stat) ± 1° (sys) for PLANCK data and α = 0.30° ± 0.27° (stat) ± 1° (sys) for BKP data. We finally forecast the expected improvements over present constraints when the PLANCK BB, TB and EB spectra at high ℓ will be included in the analysis.
DEFF Research Database (Denmark)
Wei, Lei; Alkeskjold, Thomas Tanggaard; Bjarklev, Anders Overgaard
2009-01-01
We demonstrate the first compact electrically tunable and rotatable birefringence controller based on LCPBG fibers. The birefringence can be tuned electrically to work as a quarter-wave or a half-wave plate in the wavelength range 1520nm-1600nm.......We demonstrate the first compact electrically tunable and rotatable birefringence controller based on LCPBG fibers. The birefringence can be tuned electrically to work as a quarter-wave or a half-wave plate in the wavelength range 1520nm-1600nm....
Liu, Qiang; Gross, S; Dekker, P; Withford, M J; Steel, M J
2014-11-17
We consider the process of Faraday rotation in femtosecond laser direct-write waveguides. The birefringence commonly associated with such waveguides may be expected to impact the observable Faraday rotation. Here, we theoretically calculate and experimentally verify the competition between Faraday rotation and birefringence in two waveguides created by laser writing in a commercial magneto-optic glass. The magnetic field applied to induce Faraday rotation is nonuniform, and as a result, we find that the two effects can be clearly separated and used to accurately determine even weak birefringence. The birefringence in the waveguides was determined to be on the scale of Δn = 10(-6) to 10(-5). The reduction in Faraday rotation caused by birefringence of order Δn = 10(-6) was moderate and we obtained approximately 9° rotation in an 11 mm waveguide. In contrast, for birefringence of order 10(-5), a significant reduction in the polarization azimuth change was found and only 6° rotation was observed.
Energy Technology Data Exchange (ETDEWEB)
Martinez-Ponce, G.; Solano, Cristina [Centro de Investigaciones en Optica A.C, Guanajuato (Mexico)
2001-02-01
The propagation of a plane electromagnetic wave through a grating using the modal theory is analyzed. The eigenproblem is solved in function of the ratio illumination wavelength {lambda} to grating period (d). When this ratio is much greater than one (quasiestatic limit), the grating shows a response similar to an uniaxial film. It is possible to approximate the eigenfunction for calculating the effective refractive indices of the birefringent element. This effect is called form birefringence and can be used to design retardation plates. [Spanish] En este trabajo se analiza la propagacion de una onda electromagnetica plana a traves de una rejilla utilizando la teoria modal. Estableciendo el problema de valor caracteristico se determina que la solucion es dependiente de la razon longitud de onda de iluminacion {lambda} y el periodo de la rejilla (d). En el caso {lambda}/d mayor que 1, conocido como el limite cuasiestatico, la rejilla se comporta como una pelicula uniaxial, obteniendose los indices ordinario y extraordinario a partir de una aproximacion a la ecuacion caracteristica. Este fenomeno, llamado birrefringencia de forma, puede emplearse para disenar elementos birrefringentes.
A Novel Low Loss, Highly Birefringent Photonic Crystal Fiber in THz Regime
DEFF Research Database (Denmark)
Hasanuzzaman, G. K. M.; Rana, Sohel; Habib, Selim
2016-01-01
We present a new kind of dual-hole unit-based porous-core hexagonal photonic crystal fiber (H-PCF) with low loss and high birefringence in terahertz regime. The proposed fiber offers simultaneously high birefringence and low effective material loss (EML) in the frequency range of 0.5-0.85 THz wit...
Energy Technology Data Exchange (ETDEWEB)
Gan, Ma [State Optical Institute, Birzhevaya linia, 12 St. Petersburg (Russian Federation); Kushtal, Gi; Skomorovsky, Vi; Domyshev, Gn; Sadokhin, Vp [Institute of Solar-Terrestrial Physics Siberian Branch of Russian Academy of Sciences, 126 Lermontova Str., PO 4026, 664033, Irkutsk (Russian Federation)
2006-10-15
The finishing of birefringent plates consists of two processes: polishing and evaluation of a surface, which have been performed separately till now. The purpose of this work is achieving of high accuracy of the evaluation and machining of the plane-parallel plates from birefringent crystals, in particular of crystal plates of birefringent filters during their finishing. The developed process combines evaluation and polishing in an interactive way. We have found modes of treatment, shape of polisher, have designed interferometer, with a mirror arranged in polisher. Visual checking of optical thickness comparatively with reference plate was carried out using the interference fringes of equal birefringence, and checking of an optical wedge - by interference rings of an equal inclination. The automated processing of TV camera interference fringes was impossible, because of gaps of interference fringes on polishing cells above the mirror. Therefore a special software was developed for processing of a complex fringe pattern interferogram. Software FastInterf uses furrier analysis technique which allows to process an interferogram with multiply gaps. Interferograms are registered by a high resolution TV camera (1280 x1024). Automatic processing of a fringe interferogram using FastInterf software takes less then one second. The influence of gaps is excluded, and the flat field is taken into account. Software provides full 3D surface and wavefront maps. Aberration analysis of a wavefront gives information on thickness of a plate comparatively with a reference one, optical wedge of plate and azimuth of an inclination of wave front. Moreover, software provides a control of surface quality. The measuring device, features of the software are described and process of interferometric evaluation during polishing is illustrated.
Directory of Open Access Journals (Sweden)
Scott O’Meara
2013-05-01
Full Text Available In the western United States, federal, state, and local agencies have engaged in extensive efforts to detect the presence of larval dreissenid mussels (veligers in water bodies before such a presence becomes a full-scale infestation. Cross-polarized light microscopy (CPLM is commonly used to detect the veliger’s specific birefringence pattern, but the effect of sample preservation on dreissenid birefringence has not yet been determined. This study examined the effects of solution pH, ethanol concentration, and storage temperature on veliger birefringence loss. Birefringence loss was determined by examining veligers under CPLM at regular intervals over a 30 day period. Veliger birefringence loss was below five percent in all basic solutions, regardless of holding temperature or ethanol concentration. Veliger birefringence loss was also below five percent in acidic solutions that were refrigerated or contained 50–70 percent ethanol. Veligers in acidic solutions that were held at 25°C and 34°C with 0–25 percent ethanol had 7–25 percent veliger birefringence loss over a 30 day period. While ethanol addition and refrigeration are both important preservation methods, the results of this study indicate that samples collected for dreissenid veliger detection by CPLM must also be maintained at a basic pH in order to preserve veliger shell integrity and birefringence. Determining the best conditions for long-term preservation of veliger shells requires further investigation, and these results should not be assumed best for analyses other than CPLM.
Parametric resonance in quantum electrodynamics vacuum birefringence
Arza, Ariel; Elias, Ricardo Gabriel
2018-05-01
Vacuum magnetic birefringence is one of the most interesting nonlinear phenomena in quantum electrodynamics because it is a pure photon-photon result of the theory and it directly signalizes the violation of the classical superposition principle of electromagnetic fields in the full quantum theory. We perform analytical and numerical calculations when an electromagnetic wave interacts with an oscillating external magnetic field. We find that in an ideal cavity, when the external field frequency is around the electromagnetic wave frequency, the normal and parallel components of the wave suffer parametric resonance at different rates, producing a vacuum birefringence effect growing in time. We also study the case where there is no cavity and the oscillating magnetic field is spatially localized in a region of length L . In both cases we find also a rotation of the elliptical axis.
Polarisation Control of DFB Fibre Laser Using UV-Induced Birefringent Phase-Shift
DEFF Research Database (Denmark)
Philipsen, Jacob Lundgreen; Lauridsen, Vibeke Claudia; Berendt, Martin Ole
1998-01-01
The polarisation properties of a distributed feedback (DFB) fibre laser are investigated experimentally. A birefringent phase-shift is induced by side illumination of the centre part of the lasing structure with ultraviolet (UV) light and it is experimentally shown that the birefringence...... of the phase-shift is the dominating effect controlling the polarisation properties of the laser....
The measurement system of birefringence and Verdet constant of optical fiber
Huang, Yi; Chen, Li; Guo, Qiang; Pang, Fufei; Wen, Jianxiang; Shang, Yana; Wang, Tingyun
2013-12-01
The Faraday magneto-optical effect of optical fiber has many applications in monitoring magnetic field and electric current. When a linearly polarized light propagates in the direction of a magnetic field, the plane of polarization will rotate linearly proportional to the strength of the applied magnetic field, which following the relationship of θF =VBl. θF is the Faraday rotation angle, which is proportional to the magnetic flux density B and the Verdet constant V . However, when the optical fiber contains the effect of linear birefringence, the detection of Faraday rotation angle will depend on the line birefringence. In order to determine the Verdet constant of an optical fiber under a linear birefringence, the fiber birefringence needs to be accurately measured. In this work, a model is applied to analyze the polarization properties of an optical fiber by using the Jones matrix method. A measurement system based on the lock-in amplifier technology is designed to test the Verdet constant and the birefringence of optical fiber. The magnetic field is produced by a solenoid with a DC current. A tunable laser is intensity modulated with a motorized rotating chopper. The actuator supplies a signal as the phase-locked synchronization reference to the signal of the lock-in amplifier. The measurement accuracy is analyzed and the sensitivity of the system is optimized. In this measurement system, the Verdet constant of the SMF-28 fiber was measured to be 0.56±0.02 rad/T·m at 1550nm. This setup is well suitable for measuring the high signal-to-noise ratio (SNR) sensitivity for lock-in amplifier at a low magnetic field strength.
Magneto-optic current sensor with Faraday mirror for linear birefringence compensation
Arroyo Breña, Javier; Rodriguez Horche, Paloma; Martín Minguez, Alfredo
2012-01-01
Fiber optic sensors have some advantages in subjects related with electrical current and magnetic field measurement. In spite of the optical fiber utilization advantages we have to take into account undesirable effects, which are present in real non-ideal optical fibers. In telecommunication and sensor application fields the presence of inherent and induced birefringence is crucial. The presence of birefringence may cause an undesirable change in the polarization state. In order to compensate...
Cancellation of birefringence in DBR laser through principal axis offset by a rotation of 90°
Zaini, M. K. A.; Lai, M. H.; Islam, M. R.; Lim, K. S.; Ahmad, H.
2018-04-01
The cancellation of birefringence in the distributed Bragg reflector based on 90° rotation offset method is demonstrated. It is found that the birefringence, which causes the peak bifurcation has been eliminated and a single peak is produced at each resonance in the output spectrum. This modification is an economic solution for eliminating the birefringence of the optical fibre devices.
Pola Fossi, Armande; Ferrec, Yann; Guerineau, Nicolas; Roux, Nicolas; Kling, Emmanuel; Sauer, Hervé
2016-10-01
Hyperspectral imaging from unmanned aerial vehicles arouses a growing interest, as well for agriculture management as pollution monitoring or security purposes. Most of current instruments are in the visible or near infrared spectral range, but the midwave or longwave infrared may also be interesting. Among the available solutions for compact imaging spectrometers in this spectral range, static imaging Fourier transform spectrometers are well adapted, thanks to the absence of moving part, a 2D snapshot imaging, which can be useful for image registration, and a high flux collection efficiency. To reach a high compactness compliant with small UAVs, birefringent interferometers are good candidates. Indeed, they can be roughly seen as a plate which comes in front of the camera lens. We propose here firstly to expose the design rules of such instruments in the midwave or longwave infrared. The first point is about the material: highly birefringent uniaxial crystals materials are not so common in this spectral domain. For MWIR spectral imagers, TeO2 or YVO4 can be used. For LWIR instruments, current materials, like ZnGeP2 or AgGaS2 are available, but their birefringence is not so high. Calomel is a promising way, but not still available. The second point consists in defining the type of interferometer, like Savart interferometer, Wollaston interferometer, or other designs. To help this choice, we have developed a software tool to calculate the propagation of plane waves in a stack of birefringent plates. This allows us to choose the optimal assembly of the plates to reach the required spectral resolution. We will then present experimental results obtained with a MWIR prototype. This prototype, called SIBI,, works in the [3.7µm-4.8µm] spectral domain (or [2050cm 1-2700cm 1]), with a spectral resolution about 13cm 1. A first ground campaign was led in June 2015, on Mount Etna (Italy). This campaign was useful to emphasize the assets and drawbacks of this instrument
Stress induced birefringence in hybrid TIR/PBG guiding solid photonic crystal fibers
DEFF Research Database (Denmark)
Lyngsøe, Jens Kristian; Mangan, Brian Joseph; Olausson, Christina Bjarnal Thulin
2010-01-01
We report on two types of polarization maintaining solid photonic crystal fibers that guide light by a combination of a photonic bandgap and total internal reflection. Group and phase birefringence are studied experimentally and numerically for stress-applying parts made from B-doped and F......-doped silica. The stress field originating from Ge-doped cladding rods is shown to interfere with the stress field from the B-doped and F-doped rods. Since the differential expansion coefficients of B-doped and F-doped silica have opposite signs this interference is either destructive or constructive....... Consequently, we found that the fiber with F-doped stress applying parts has the highest modal phase birefringence, and polarization cross talk is characterized by an h-parameter below 3⋅10−5 m−1....
Correction of the phase retardation caused by intrinsic birefringence in deep UV lithography
Serebriakov, A.; Bociort, F.; Braat, J.
2005-01-01
In the year 2001 it was reported that the birefringence induced by spatial dispersion (BISD), sometimes also called intrinsic birefringence, had been measured and calculated for fluorides CaF2 and BaF2 in the deep UV range. It was also shown that the magnitude of the BISD in these cubic crystals is
Turnhout, van M.C.; Kranenbarg, S.; Leeuwen, van J.L.
2009-01-01
Quantitative polarized light microscopy (qPLM) is a popular tool for the investigation of birefringent architectures in biological tissues. Collagen, the most abundant protein in mammals, is such a birefringent material. Interpretation of results of qPLM in terms of collagen network architecture and
Liao, Jianfei; Xie, Yingmao; Wang, Xinghua; Li, Dongbo; Huang, Tianye
2017-07-01
A slot silicon photonic crystal fiber (PCF) is proposed to simultaneously achieve ultrahigh birefringence, large nonlinearity and ultra-flattened nearly-zero dispersion over a wide wavelength range. By taking advantage on the slot effect, ultrahigh birefringence up to 0.0736 and ultrahigh nonlinear coefficient up to 211.48 W-1 m-1 for quasi-TE mode can be obtained at the wavelength of 1.55 μm. Moreover, ultra-flattened dispersion of 0.49 ps/(nm km) for quasi-TE mode can be achieved over a 180 nm wavelength range with low dispersion slope of 1.85 × 10-3 ps/(nm2 km) at 1.55 μm. Leveraging on these advantages, the proposed slot PCF has great potential for efficient all-optical signal processing applications.
Imaging of irradiated human costal cartilage birefringence by PS-OCT
Energy Technology Data Exchange (ETDEWEB)
Martinho Junior, Antonio C.; Freitas, Anderson Z.; Santin, Stefany P.; Soares, Fernando A.N.; Mosca, Rodrigo C.; Bringel, Fabiana A.; Mathor, Monica B., E-mail: freitas.az@ipen.b, E-mail: rmosca@usp.b, E-mail: mathor@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)
2011-07-01
Sterilization by ionizing radiation is a technique used for tissue banks around the world to avoid transmission of infectious diseases by human allografts. However, high doses of ionizing radiation may cause undesirable changes in tissue structure, decreasing its mechanical properties, for example. Optical Coherence Tomography (OCT) is a non destructive, non ionizing and real time method to investigate biological tissues without promote any change in tissue structure. Polarization Sensitive Optical Coherence Tomography (PS-OCT) is an OCT technique that combines polarimetry with low coherence reflectometry to provide depth resolved measurements from birefringent structures as collagen. Costal cartilages from 15 cadaveric donors were preserved in high concentration glycerol and each individual sample was divided in 6 fragments. One of them was kept as a control group and the others were irradiated with gamma radiation from a Co-60 source with doses of 15, 25, 50, 75 and 100 kGy. OCT and PS-OCT images of the same region of the samples were obtained from a device OCS 1300 SS (Thorlabs, USA) with a coupling polarization module PSOCT 1300 (Thorlabs, USA). According with our results, birefringence may be visualized in all test groups as well in the control group, suggesting that sterilization by ionizing radiation does not affect the collagen structure significantly to cause total loss of birefringence, even if high doses as 75 and 100 kGy are used. The next step of our work is to develop a new method to quantify the birefringence using the optical properties of the tissue. (author)
Imaging of irradiated human costal cartilage birefringence by PS-OCT
International Nuclear Information System (INIS)
Martinho Junior, Antonio C.; Freitas, Anderson Z.; Santin, Stefany P.; Soares, Fernando A.N.; Mosca, Rodrigo C.; Bringel, Fabiana A.; Mathor, Monica B.
2011-01-01
Sterilization by ionizing radiation is a technique used for tissue banks around the world to avoid transmission of infectious diseases by human allografts. However, high doses of ionizing radiation may cause undesirable changes in tissue structure, decreasing its mechanical properties, for example. Optical Coherence Tomography (OCT) is a non destructive, non ionizing and real time method to investigate biological tissues without promote any change in tissue structure. Polarization Sensitive Optical Coherence Tomography (PS-OCT) is an OCT technique that combines polarimetry with low coherence reflectometry to provide depth resolved measurements from birefringent structures as collagen. Costal cartilages from 15 cadaveric donors were preserved in high concentration glycerol and each individual sample was divided in 6 fragments. One of them was kept as a control group and the others were irradiated with gamma radiation from a Co-60 source with doses of 15, 25, 50, 75 and 100 kGy. OCT and PS-OCT images of the same region of the samples were obtained from a device OCS 1300 SS (Thorlabs, USA) with a coupling polarization module PSOCT 1300 (Thorlabs, USA). According with our results, birefringence may be visualized in all test groups as well in the control group, suggesting that sterilization by ionizing radiation does not affect the collagen structure significantly to cause total loss of birefringence, even if high doses as 75 and 100 kGy are used. The next step of our work is to develop a new method to quantify the birefringence using the optical properties of the tissue. (author)
A bifunctional amorphous polymer exhibiting equal linear and circular photoinduced birefringences.
Royes, Jorge; Provenzano, Clementina; Pagliusi, Pasquale; Tejedor, Rosa M; Piñol, Milagros; Oriol, Luis
2014-11-01
The large and reversible photoinduced linear and circular birefringences in azo-compounds are at the basis of the interest in these materials, which are potentially useful for several applications. Since the onset of the linear and circular anisotropies relies on orientational processes, which typically occur on the molecular and supramolecular length scale, respectively, a circular birefringence at least one order of magnitude lower than the linear one is usually observed. Here, the synthesis and characterization of an amorphous polymer with a dimeric repeating unit containing a cyanoazobenzene and a cyanobiphenyl moiety are reported, in which identical optical linear and circular birefringences are induced for proper light dose and ellipticity. A pump-probe technique and an analytical method based on the Stokes-Mueller formalism are used to investigate the photoinduced effects and to evaluate the anisotropies. The peculiar photoresponse of the polymer makes it a good candidate for applications in smart functional devices. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
International Nuclear Information System (INIS)
Ohashi, M.; Kitayama, K.; Ishida, Y.; Uchida, N.
1982-01-01
A novel method to achieve phase-matched light amplification in a birefringent fiber via the three-wave mixing is proposed by using frequency shift change due to the stress applied to the fiber. It is confirmed that the signal power from a cw laser diode at lambda = 1.292 μm is amplified by 6.1 x 10 3 times in the birefringent fiber pumped with a Q-switched Nd: yttrium aluminum garnet laser at lambda = 1.064 μm. This will provide a new fiber-optic light signal amplifier having a good tolerance for variation of signal wavelengths
Determination of pitch rotation in a spherical birefringent microparticle
Roy, Basudev; Ramaiya, Avin; Schäffer, Erik
2018-03-01
Rotational motion of a three dimensional spherical microscopic object can happen either in pitch, yaw or roll fashion. Among these, the yaw motion has been conventionally studied using the intensity of scattered light from birefringent microspheres through crossed polarizers. Up until now, however, there is no way to study the pitch motion in spherical microspheres. Here, we suggest a new method to study the pitch motion of birefringent microspheres under crossed polarizers by measuring the 2-fold asymmetry in the scattered signal either using video microscopy or with optical tweezers. We show a couple of simple examples of pitch rotation determination using video microscopy for a microsphere attached with a kinesin molecule while moving along a microtubule and of a particle diffusing freely in water.
Cavity enhanced interference of orthogonal modes in a birefringent medium
Kolluru, Kiran; Saha, Sudipta; Gupta, S. Dutta
2018-03-01
Interference of orthogonal modes in a birefringent crystal mediated by a rotator is known to lead to interesting physical effects (Solli et al., 2003). In this paper we show that additional feedback offered by a Fabry-Perot cavity (containing the birefringent crystal and the rotator) can lead to a novel strong interaction regime. Usual signatures of the strong interaction regime like the normal mode splitting and avoided crossings, sensitive to the rotator orientation, are reported. A high finesse cavity is shown to offer an optical setup for measuring small angles. The results are based on direct calculations of the cavity transmissions along with an analysis of its dispersion relation.
The PVLAS experiment for measuring the magnetic birefringence of vacuum
International Nuclear Information System (INIS)
Zavattini, G.; Gastaldi, U.; Messineo, G.; Piemontese, L.; Della Valle, F.; Milotti, E.; Pengo, R.; Ruoso, G.
2013-01-01
We describe the principle and status of the PVLAS experiment being prepared at the Department of Physics and INFN section in Ferrara, Italy. The goal of the experiment is to measure the magnetic birefringence of vacuum. This effect is directly connected to the vacuum QED structure and can be detected by measuring the ellipticity acquired by a linearly polarized laser beam traversing a strong magnetic field. Vacuum magnetic birefringence is predicted by the Euler- Heisenberg effective Lagrangian. The experimental method is also sensitive to new physics and could place new laboratory limits to hypothetical particles coupling to two photons, such as axion like particles, or millicharged particles.
Nechifor, Cristina-Delia; Zelinschi, Carmen Beatrice; Dorohoi, Dana-Ortansa
2014-03-01
The aim of our paper is to evidence the influence of Gamma and UV radiations on the induced birefringence of poly(vinyl alcohol) stretched foils. Thin foils of PVA were prepared and dried without modifying their surfaces. The polymeric foils were irradiated from 15 min to 6 h using UV and Gamma radiations. The induced by stretching under heating birefringence of PVA films was measured at λ = 589.3 nm with a Babinet Compensator. Physico-chemical processes (photo stabilization, photo degradation, oxidation) induced by irradiation of polymer matrix influence both the stretching degree and the anisotropy of etired foils. An increase of birefringence versus the stretching ratio of the PVA foils was evidenced for all studied samples. The dependence of the birefringence on the exposure time, stretching ratio and nature of radiation was also confirmed.
Pirnstill, Casey W; Malik, Bilal H; Gresham, Vincent C; Coté, Gerard L
2012-09-01
Over the past 35 years considerable research has been performed toward the investigation of noninvasive and minimally invasive glucose monitoring techniques. Optical polarimetry is one noninvasive technique that has shown promise as a means to ascertain blood glucose levels through measuring the glucose concentrations in the anterior chamber of the eye. However, one of the key limitations to the use of optical polarimetry as a means to noninvasively measure glucose levels is the presence of sample noise caused by motion-induced time-varying corneal birefringence. In this article our group presents, for the first time, results that show dual-wavelength polarimetry can be used to accurately detect glucose concentrations in the presence of motion-induced birefringence in vivo using New Zealand White rabbits. In total, nine animal studies (three New Zealand White rabbits across three separate days) were conducted. Using the dual-wavelength optical polarimetric approach, in vivo, an overall mean average relative difference of 4.49% (11.66 mg/dL) was achieved with 100% Zone A+B hits on a Clarke error grid, including 100% falling in Zone A. The results indicate that dual-wavelength polarimetry can effectively be used to significantly reduce the noise due to time-varying corneal birefringence in vivo, allowing the accurate measurement of glucose concentration in the aqueous humor of the eye and correlating that with blood glucose.
CMB polarization systematics, cosmological birefringence, and the gravitational waves background
International Nuclear Information System (INIS)
Pagano, Luca; Bernardis, Paolo de; Gubitosi, Giulia; Masi, Silvia; Melchiorri, Alessandro; Piacentini, Francesco; De Troia, Grazia; Natoli, Paolo; Polenta, Gianluca
2009-01-01
Cosmic microwave background experiments must achieve very accurate calibration of their polarization reference frame to avoid biasing the cosmological parameters. In particular, a wrong or inaccurate calibration might mimic the presence of a gravitational wave background, or a signal from cosmological birefringence, a phenomenon characteristic of several nonstandard, symmetry breaking theories of electrodynamics that allow for in vacuo rotation of the polarization direction of the photon. Noteworthly, several authors have claimed that the BOOMERanG 2003 (B2K) published polarized power spectra of the cosmic microwave background may hint at cosmological birefringence. Such analyses, however, do not take into account the reported calibration uncertainties of the BOOMERanG focal plane. We develop a formalism to include this effect and apply it to the BOOMERanG dataset, finding a cosmological rotation angle α=-4.3 deg. ±4.1 deg. We also investigate the expected performances of future space borne experiment, finding that an overall miscalibration larger then 1 deg. for Planck and 0.2 deg. for the Experimental Probe of Inflationary Cosmology, if not properly taken into account, will produce a bias on the constraints on the cosmological parameters and could misleadingly suggest the presence of a gravitational waves background.
X-ray Birefringence: A New Strategy for Determining Molecular Orientation in Materials.
Palmer, Benjamin A; Edwards-Gau, Gregory R; Morte-Ródenas, Anabel; Kariuki, Benson M; Lim, Gin Keat; Harris, Kenneth D M; Dolbnya, Igor P; Collins, Stephen P
2012-11-01
While the phenomenon of birefringence is well-established in the case of visible radiation and is exploited in many fields (e.g., through the use of the polarizing optical microscope), the analogous phenomenon for X-rays has been a virtually neglected topic. Here, we demonstrate the scope and potential for exploiting X-ray birefringence to determine the orientational properties of specific types of bonds in solids. Specifically, orientational characteristics of C-Br bonds in the bromocyclohexane/thiourea inclusion compound are elucidated from X-ray birefringence measurements at energies close to the bromine K-edge, revealing inter alia the changes in the orientational distribution of the C-Br bonds associated with a low-temperature order-disorder phase transition. From fitting a theoretical model to the experimental data, reliable quantitative information on the orientational properties of the C-Br bonds is determined. The experimental strategy reported here represents the basis of a new approach for gaining insights into the orientational properties of molecules in anisotropic materials.
Jaspers, Mariëlle E. H.; Feroldi, Fabio; Vlig, Marcel; de Boer, Johannes F.; van Zuijlen, Paul P. M.
2017-12-01
Obtaining adequate information on scar characteristics is important for monitoring their evolution and the effectiveness of clinical treatment. The aberrant type of collagen in scars may give rise to specific birefringent properties, which can be determined using polarization-sensitive optical coherence tomography (PS-OCT). The aim of this pilot study was to evaluate a method to quantify the birefringence of the scanned volume and correlate it with the collagen density as measured from histological slides. Five human burn scars were measured in vivo using a handheld probe and custom-made PS-OCT system. The local retardation caused by the tissue birefringence was extracted using the Jones formalism. To compare the samples, histograms of birefringence values of each volume were produced. After imaging, punch biopsies were harvested from the scar area of interest and sent in for histological evaluation using Herovici polychrome staining. Two-dimensional en face maps showed higher birefringence in scars compared to healthy skin. The Pearson's correlation coefficient for the collagen density as measured by histology versus the measured birefringence was calculated at r=0.80 (p=0.105). In conclusion, the custom-made PS-OCT system was capable of in vivo imaging and quantifying the birefringence of human burn scars, and a nonsignificant correlation between PS-OCT birefringence and histological collagen density was found.
Constraints on cosmological birefringence energy dependence from CMB polarization data
International Nuclear Information System (INIS)
Gubitosi, G.; Paci, F.
2013-01-01
We study the possibility of constraining the energy dependence of cosmological birefringence by using CMB polarization data. We consider four possible behaviors, characteristic of different theoretical scenarios: energy-independent birefringence motivated by Chern-Simons interactions of the electromagnetic field, linear energy dependence motivated by a 'Weyl' interaction of the electromagnetic field, quadratic energy dependence, motivated by quantum gravity modifications of low-energy electrodynamics, and inverse quadratic dependence, motivated by Faraday rotation generated by primordial magnetic fields. We constrain the parameters associated to each kind of dependence and use our results to give constraints on the models mentioned. We forecast the sensitivity that Planck data will be able to achieve in this respect
Directory of Open Access Journals (Sweden)
Sergey V. Arkhipov
2017-09-01
Full Text Available Subject of Research.The paper deals with mutlipulse inscription comparative results of the type IBragg gratings in the birefringent optical fiber with elliptical stress cladding and increased GeO2 concentration at different birefringence axes positions. Method. The gratings were inscribed by the phase mask method. The excimer laser Coherent COMPexPro 102F, working with the gas mixture KrF (248 nm, was used as the radiation source. The phase mask Ibsen Photonics with a period of1065.3 nm was used. Main Results.The results have shown that the multipusle inscription is more effective and has better dynamics when the plane containing the fiber axis and its slow birefringence axis is parallel to the writing radiation incidence plane containing the fiber axis. Practical Relevance. The research results give the possibility to make recommendations for the multipulse Bragg gratings inscription efficiency enhancement in the specialty birefringent fibers. The preinscription positioning of birefringence axes also makes it possible to reduce the polarization fading that is the noise source in phase interferometric sensors.
Tsuchida, Satoshi; Kuratsuji, Hiroshi
2018-05-01
A stochastic theory is developed for the light transmitting the optical media exhibiting linear and nonlinear birefringence. The starting point is the two-component nonlinear Schrödinger equation (NLSE). On the basis of the ansatz of “soliton” solution for the NLSE, the evolution equation for the Stokes parameters is derived, which turns out to be the Langevin equation by taking account of randomness and dissipation inherent in the birefringent media. The Langevin equation is converted to the Fokker-Planck (FP) equation for the probability distribution by employing the technique of functional integral on the assumption of the Gaussian white noise for the random fluctuation. The specific application is considered for the optical rotation, which is described by the ellipticity (third component of the Stokes parameters) alone: (i) The asymptotic analysis is given for the functional integral, which leads to the transition rate on the Poincaré sphere. (ii) The FP equation is analyzed in the strong coupling approximation, by which the diffusive behavior is obtained for the linear and nonlinear birefringence. These would provide with a basis of statistical analysis for the polarization phenomena in nonlinear birefringent media.
Chanan, G. A.; Novick, R.; Silver, E. H.
1979-01-01
The birefringence of the vacuum in the presence of strong (of the order of 1 teragauss) magnetic fields will in general affect the polarization of X-rays propagating through these fields. Two of the four Stokes parameters will vary so rapidly with wavelength as to be 'washed out' and unobservable, but the remaining two parameters will be unaffected. These results show that one conclusion of an earlier work is incorrect: Polarized X-ray emission from the surface of a magnetic neutron star will not in general be completely depolarized by the effects of vacuum birefringence. In particular, this birefringence has no effect on the linear polarization of cyclotron emission from the poles of magnetic neutron stars, and a similar result holds for synchrotron emission. More general cases of the propagation of polarized X-rays in magnetic fields are also discussed.
Analysis of Indexed-Guided Highly Birefringent Photonic Crystal ...
African Journals Online (AJOL)
In this paper, a comparative study of three geometries of highly birefringent photonic crystal fibers (HB PCF) is presented. The proposed geometries are: V type PCF, Pseudo-Panda PCF and selectively liquid-filled PCF. Based on the famous Finite Difference Time Domain (FDTD) method with the perfectly matched layer ...
Polarization modulational instability in a birefringent optical fiber ...
Indian Academy of Sciences (India)
effects on PMI gain spectra of a linearly polarized intense pump wave which experiences periodic nonlinear polarization rotation in a birefringent optical fiber in both the anomalous and normal dispersion regimes. The paper is arranged as follows: In Ü2, we briefly discuss the basic equation. In Ü3, using Floquet theorem ...
Measurement of stress-induced birefringence in glasses based on reflective laser feedback effect
Haisha, Niu; YanXiong, Niu; Jiyang, Li
2017-02-01
A glass birefringence measurement system utilizing the reflective laser feedback (RLF) effect is presented. The measurement principle is analyzed based on the equivalent cavity of a Fabry-Perot interferometer, and the experiments are conducted with a piece of quartz glass with applied extrusion force. In the feedback system, aluminum film used as a feedback mirror is affixed to the back of the sample. When the light is reflected back into the cavity, as the reinjected light is imprinted with the birefringence information in the sample, the gain and polarization states of the laser are modulated. The variation of optical power and polarization states hopping is monitored to obtain the magnitude of the stress. The system has advantages such as simplicity and low-cost with a precision of 1.9 nm. Moreover, by adjusting the position of the aluminum, large-area samples can be measured anywhere at any place.
Wada, D.; Murayama, H.
2014-01-01
When Fiber Bragg gratings (FBGs) are used as strain sensors, both longitudinal and lateral strain can be applied uniformly or non-uniformly over the length of the FBGs. In order for the demodulation of such FBG signal, this paper investigates the response of birefringent FBGs which are monitored by distributed measurement system based on optical frequency domain reflectometry. A numerical model of the distributed measurement system is built based on piece-wise uniform approach, which considers polarization states of propagating lights. The numerical model simulates analytical response of birefringent FBGs especially when birefringence induces power fluctuations in the distributed spectra, which can be noise or new opportunity for sensitive monitoring of birefringence. Simulation results show the relationships between the power fluctuations and the polarization states of the propagating lights. Consequently, appropriate methods of polarization control for sensitive distributed birefringent FBG monitoring are discussed.
Spectral-Domain Measurement of Strain Sensitivity of a Two-Mode Birefringent Side-Hole Fiber
Directory of Open Access Journals (Sweden)
Waclaw Urbanczyk
2012-09-01
Full Text Available The strain sensitivity of a two-mode birefringent side-hole fiber is measured in the spectral domain. In a simple experimental setup comprising a broadband source, a polarizer, a two-mode birefringent side-hole fiber under varied elongations, an analyzer and a compact spectrometer, the spectral interferograms are resolved. These are characterized by the equalization wavelength at which spectral interference fringes have the highest visibility (the largest period due to the zero group optical path difference between the fundamental, the LP01 mode and the higher-order, the LP11 mode. The spectral interferograms with the equalization wavelength are processed to retrieve the phase as a function of the wavelength. From the retrieved phase functions corresponding to different elongations of a two-mode birefringent side-hole fiber under test, the spectral strain sensitivity is obtained. Using this approach, the intermodal spectral strain sensitivity was measured for both x and y polarizations. Moreover, the spectral polarimetric sensitivity to strain was measured for the fundamental mode when a birefringent delay line was used in tandem with the fiber. Its spectral dependence was also compared with that obtained from a shift of the spectral interferograms not including the equalization wavelength, and good agreement was confirmed.
Li, Y.; Zhou, X. M.; Cai, Y.; Liu, C. L.; Luo, S. N.
2018-04-01
[100] CaF2 single crystals are shock-compressed via symmetric planar impact, and the flyer plate-target interface velocity histories are measured with a laser displacement interferometry. The shock loading is slightly above the Hugoniot elastic limit to investigate incipient plasticity and its kinetics, and its effects on optical properties and deformation inhomogeneity. Fringe patterns demonstrate different features in modulation of fringe amplitude, including birefringence and complicated modulations. The birefringence is attributed to local lattice rotation accompanying incipient plasticity. Spatially resolved measurements show inhomogeneity in deformation, birefringence, and fringe pattern evolutions, most likely caused by the inhomogeneity associated with lattice rotation and dislocation slip. Transiently overdriven elastic states are observed, and the incubation time for incipient plasticity decreases inversely with increasing overdrive by the elastic shock.
Birefringent Microlens Array for Ultra High Resolution HMDs, Phase I
National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project will be used to analyze, design, model, and test a birefringent microlens array for use in a new type of...
Zi, Jianchen
2018-02-15
Metamaterials have been widely applied in the polarization conversion of terahertz (THz) waves. However, common plasmonic metamaterials usually work as reflective devices and have low transmissions. All-dielectric metamaterials can overcome these shortcomings. An all-dielectric metamaterial based on silicon with elliptical air holes is reported to achieve high artificial birefringence at THz frequencies. Simulations show that with appropriate structural parameters the birefringence of the dielectric metamaterial can remain flat and is above 0.7 within a broad band. Moreover, the metamaterial can be designed as a broadband quarter wave plate. A sample metamaterial was fabricated and tested to prove the validity of the simulations, and the sample could work as a quarter wave plate at 1.76 THz. The all-dielectric metamaterial that we proposed is of great significance for high performance THz polarization converters.
Directory of Open Access Journals (Sweden)
E. A. Nikulina
2015-03-01
Full Text Available Subject of study. A vector model for conversion of electromagnetic radiation in optical systems is considered, taking into account the influence of birefringence, as well as partially coherent illumination. Model. The proposed model is based on the representation of the complex amplitude of the monochromatic field through thesuperposition of basic plane waves. Transmitted light image with partially coherent illumination is performed by the sourceintegration method. Main results. The results of simulation for the point spread function are demonstrating the level of the birefringence influence on the image quality. In the presence of the wave aberration about 0.098 of the wavelength, the wave energy loss in the center of the Airy disk with an average birefringence of 4 nm/cm was 8%, and at 16 nm/cm it reached 30%. The calculation of the point spread function for a real sample of fluorite is given. The central peak of the PSF without birefringence was 0.722, with regard to birefringence it was equal to 0.701. Practical significance. The findings can be used in the development of photolithographic lenses, as well as for the manufacturing of any other optical systems that require consideration of the polarization properties of the materials.
Malykin, G. B.; Pozdnyakova, V. I.
2018-03-01
A linear transformation of orthogonal polarization modes in coiled optical spun-fibers with strong unperturbed linear birefringence, which causes the emergence of the dependences of the integrated elliptical birefringence and the ellipticity and azimuth of the major axis of the ellipse, as well as the polarization state of radiation (PSR), on the length of optical fiber has been considered. Optical spun-fibers are subjected to a strong mechanical twisting, which is frozen into the structure of the optical fiber upon cooling, in the process of being drawn out from the workpiece. Since the values of the local polarization parameters of coiled spunwaveguides vary according to a rather complex law, the calculations were carried out by numerical modeling of the parameters of the Jones matrices. Since the rotation speed of the axes of the birefringence is constant on a relatively short segment of a coiled optical spun-fiber in the accompanying torsion (helical) coordinate system, the so-called "Ginzburg helical polarization modes" (GHPMs)—two mutually orthogonal ellipses with the opposite directions of traversal, the axis of which rotate relative to the fixed coordinate system uniformly and unidirectionally—are approximately the local normal polarization modes of such optical fiber. It has been shown that, despite the fact that the unperturbed linear birefringence of the spun-fibers significantly exceeds the linear birefringence, which is caused by the winding on a coil, the integral birefringence of an extended segment of such a fiber coincides in order of magnitude with the linear birefringence, which is caused by the winding on the coil, and the integral polarization modes tend asymptotically to circular ones. It has been also shown that the values of the circular birefringence of twisted single-mode fibers, which were calculated in a nonrotating and torsion helical coordinate systems, differ significantly. It has been shown that the polarization phenomena occur
Hydrostatic Pressure Sensing with High Birefringence Photonic Crystal Fibers
Fávero, Fernando C.; Quintero, Sully M. M.; Martelli, Cicero; Braga, Arthur M.B.; Silva, Vinícius V.; Carvalho, Isabel C. S.; Llerena, Roberth W. A.; Valente, Luiz C. G.
2010-01-01
The effect of hydrostatic pressure on the waveguiding properties of high birefringence photonic crystal fibers (HiBi PCF) is evaluated both numerically and experimentally. A fiber design presenting form birefringence induced by two enlarged holes in the innermost ring defining the fiber core is investigated. Numerical results show that modal sensitivity to the applied pressure depends on the diameters of the holes, and can be tailored by independently varying the sizes of the large or small holes. Numerical and experimental results are compared showing excellent agreement. A hydrostatic pressure sensor is proposed and demonstrated using an in-fiber modal interferometer where the two orthogonally polarized modes of a HiBi PCF generate fringes over the optical spectrum of a broad band source. From the analysis of experimental results, it is concluded that, in principle, an operating limit of 92 MPa in pressure could be achieved with 0.0003% of full scale resolution. PMID:22163435
Birefringence induced by pp-wave modes in an electromagnetically active dynamic aether
International Nuclear Information System (INIS)
Alpin, Timur Yu.; Balakin, Alexander B.
2017-01-01
In the framework of the Einstein-Maxwell-aether theory we study the birefringence effect, which can occur in the pp-wave symmetric dynamic aether. The dynamic aether is considered to be a latently birefringent quasi-medium, which displays this hidden property if and only if the aether motion is non-uniform, i.e., when the aether flow is characterized by the non-vanishing expansion, shear, vorticity or acceleration. In accordance with the dynamo-optical scheme of description of the interaction between electromagnetic waves and the dynamic aether, we shall model the susceptibility tensors by the terms linear in the covariant derivative of the aether velocity four-vector. When the pp-wave modes appear in the dynamic aether, we deal with a gravitationally induced degeneracy removal with respect to hidden susceptibility parameters. As a consequence, the phase velocities of electromagnetic waves possessing orthogonal polarizations do not coincide, thus displaying the birefringence effect. Two electromagnetic field configurations are studied in detail: longitudinal and transversal with respect to the aether pp-wave front. For both cases the solutions are found, which reveal anomalies in the electromagnetic response on the action of the pp-wave aether mode. (orig.)
Birefringence induced by pp-wave modes in an electromagnetically active dynamic aether
Energy Technology Data Exchange (ETDEWEB)
Alpin, Timur Yu.; Balakin, Alexander B. [Kazan Federal University, Department of General Relativity and Gravitation, Institute of Physics, Kazan (Russian Federation)
2017-10-15
In the framework of the Einstein-Maxwell-aether theory we study the birefringence effect, which can occur in the pp-wave symmetric dynamic aether. The dynamic aether is considered to be a latently birefringent quasi-medium, which displays this hidden property if and only if the aether motion is non-uniform, i.e., when the aether flow is characterized by the non-vanishing expansion, shear, vorticity or acceleration. In accordance with the dynamo-optical scheme of description of the interaction between electromagnetic waves and the dynamic aether, we shall model the susceptibility tensors by the terms linear in the covariant derivative of the aether velocity four-vector. When the pp-wave modes appear in the dynamic aether, we deal with a gravitationally induced degeneracy removal with respect to hidden susceptibility parameters. As a consequence, the phase velocities of electromagnetic waves possessing orthogonal polarizations do not coincide, thus displaying the birefringence effect. Two electromagnetic field configurations are studied in detail: longitudinal and transversal with respect to the aether pp-wave front. For both cases the solutions are found, which reveal anomalies in the electromagnetic response on the action of the pp-wave aether mode. (orig.)
Infrared birefringence imaging of residual stress and bulk defects in multicrystalline silicon
Energy Technology Data Exchange (ETDEWEB)
Ganapati, Vidya; Schoenfelder, Stephan; Castellanos, Sergio; Oener, Sebastian; Koepge, Ringo; Sampson, Aaron; Marcus, Matthew A.; Lai, Barry; Morhenn, Humphrey; Hahn, Giso; Bagdahn, Joerg; Buonassisi1, Tonio
2010-05-05
This manuscript concerns the application of infrared birefringence imaging (IBI) to quantify macroscopic and microscopic internal stresses in multicrystalline silicon (mc-Si) solar cell materials. We review progress to date, and advance four closely related topics. (1) We present a method to decouple macroscopic thermally-induced residual stresses and microscopic bulk defect related stresses. In contrast to previous reports, thermally-induced residual stresses in wafer-sized samples are generally found to be less than 5 MPa, while defect-related stresses can be several times larger. (2) We describe the unique IR birefringence signatures, including stress magnitudes and directions, of common microdefects in mc-Si solar cell materials including: {beta}-SiC and {beta}-Si{sub 3}N{sub 4} microdefects, twin bands, nontwin grain boundaries, and dislocation bands. In certain defects, local stresses up to 40 MPa can be present. (3) We relate observed stresses to other topics of interest in solar cell manufacturing, including transition metal precipitation, wafer mechanical strength, and minority carrier lifetime. (4) We discuss the potential of IBI as a quality-control technique in industrial solar cell manufacturing.
Birefringent coherent diffraction imaging
Karpov, Dmitry; dos Santos Rolo, Tomy; Rich, Hannah; Kryuchkov, Yuriy; Kiefer, Boris; Fohtung, E.
2016-10-01
Directional dependence of the index of refraction contains a wealth of information about anisotropic optical properties in semiconducting and insulating materials. Here we present a novel high-resolution lens-less technique that uses birefringence as a contrast mechanism to map the index of refraction and dielectric permittivity in optically anisotropic materials. We applied this approach successfully to a liquid crystal polymer film using polarized light from helium neon laser. This approach is scalable to imaging with diffraction-limited resolution, a prospect rapidly becoming a reality in view of emergent brilliant X-ray sources. Applications of this novel imaging technique are in disruptive technologies, including novel electronic devices, in which both charge and spin carry information as in multiferroic materials and photonic materials such as light modulators and optical storage.
Towards a direct measurement of vacuum magnetic birefringence: PVLAS achievements
Della Valle, F.; Di Domenico, G.; Gastaldi, U.; Milotti, E.; Pengo, R.; Ruoso, G.; Zavattini, G.
2010-11-01
Nonlinear effects in vacuum have been predicted but never observed yet directly. The PVLAS collaboration has long been working on an apparatus aimed at detecting such effects by measuring vacuum magnetic birefringence. Unfortunately the sensitivity has been affected by unaccounted noise and systematics since the beginning. A new small prototype ellipsometer has been designed and characterized at the Department of Physics of the University of Ferrara, Italy entirely mounted on a single seismically isolated optical bench. With a finesse F = 414,000 and a cavity length L = 0.5 m we have reached the sensitivity of ψ=2ṡ101/√{Hz} given the laser power at the output of the ellipsometer of P = 24 mW. This record result, very close to the predicted limit, demonstrates the feasibility of reaching such sensitivities, and opens the way to designing a dedicated apparatus for a first detection of vacuum magnetic birefringence.
Improvement of chirped pulse contrast using electro-optic birefringence scanning filter method
International Nuclear Information System (INIS)
Zeng Shuguang; Wang Xianglin; Wang Qishan; Zhang Bin; Sun Nianchun; Wang Fei
2013-01-01
A method using scanning filter to improve the contrast of chirped pulse is proposed, and the principle of this method is analyzed. The scanning filter is compared with the existing pulse-picking technique and nonlinear filtering technique. The scanning filter is a temporal gate that is independent on the intensity of the pulses, but on the instantaneous wavelengths of light. Taking the electro-optic birefringence scanning filter as an example, the application of scanning filter methods is illustrated. Based on numerical simulation and experimental research, it is found that the electro-optic birefringence scanning filter can eliminate a prepulse which is several hundred picoseconds before the main pulse, and the main pulse can maintain a high transmissivity. (authors)
Highly birefringent phase-shifted fiber Bragg gratings inscribed with femtosecond laser.
He, Jun; Wang, Yiping; Liao, Changrui; Wang, Qiaoni; Yang, Kaiming; Sun, Bing; Yin, Guolu; Liu, Shen; Zhou, Jiangtao; Zhao, Jing
2015-05-01
We demonstrate a highly birefringent phase-shifted fiber Bragg grating (PS-FBG) inscribed in H2-free fiber with a near-infrared femtosecond Gaussian laser beam and uniform phase mask. The PS-FBG was fabricated from an ordinary fiber Bragg grating (FBG) in a case in which overexposure was applied. The spectral evolution from FBG to FS-FBG was observed experimentally with a decrease in transmission loss at dip wavelength, blueshift of the dip wavelength, decrease in the cladding mode loss, and an increase in the insertion loss. A high birefringence was demonstrated experimentally with the existence of PS-FBG only in TM polarization. The formation of the PS-FBG may be due to a negative index change induced by the higher intensity in the center of the Gaussian laser beam.
Constraints on direction-dependent cosmic birefringence from Planck polarization data
Contreras, Dagoberto; Boubel, Paula; Scott, Douglas
2017-12-01
Cosmic birefringence is the process that rotates the plane of polarization by an amount, α, as photons propagate through free space. Such an effect arises in parity-violating extensions to the electromagnetic sector, such as the Chern-Simons term common in axion models, quintessence models, or Lorentz-violating extensions to the standard model. Most studies consider the monopole of this rotation, but it is also possible for the effect to have spatial anisotropies. Paying particular attention to large scales, we implement a novel pixel-based method to extract the spherical harmonics for L 30. Our results are consistent with no detection and we set 95 % upper limits on the amplitude of a scale-invariant power spectrum of L(L+1)CL/2π<[2.2 (stat.)±0.7 (syst.)]×10-5=[0.07 (stat.)±0.02 (syst.)] deg2, on par with previous constraints. This implies specific limits on the dipole and quadrupole amplitudes to be √C1/4π lesssim 0.o2 and √C2/4π lesssim 0.o1, at 95 % CL, respectively, improving previous constraints by an order of magnitude. We further constrain a model independent M=0 quadrupole in an arbitrary direction to be α20 = 0.o02 ± 0.o21, with an unconstrained direction. However, we find an excess of dipolar power with an amplitude √3C1/4π = 0.o32±0.o10 (stat.)±0.o08 (syst.)], in the direction (l,b)=(295o,17o)±(22o,17o) (stat.)±(5o,16o) (syst.), larger than 1.4 % of simulations with no birefringence. We attribute part of this signal to the contamination of residual foregrounds not accounted for in our simulations, although this should be further investigated.
Kerr ellipticity effect in a birefringent optical fiber
International Nuclear Information System (INIS)
Ishiekwene, G.C.; Mensah, S.Y.; Brown, C.S.
2004-09-01
An intensity-dependent change in the ellipticity of an input light beam leads to a characteristic shift in polarization instability. Dichroism gives rise to a self-induced ellipticity effect in the polarization state of an intense input light oriented along the fast axis of a birefringent optical fiber. The critical power at which the fiber effective beat length becomes infinite is reduced considerably in the presence of dichroism. (author)
Golub, Ilya; Exir, Hourieh
2013-05-01
We present a left-right symmetry restoring method, which removes the detrimental birefringence in the single-mode fiber Sagnac interferometer, achieved with the aid of a half waveplate oriented at a specific angle. We show theoretically and demonstrate experimentally that adding a π-shift between clockwise and counterclockwise propagating, horizontally (in fiber loop plane) polarized field components, the Sagnac loop mirror's reflection becomes independent on birefringence of an element placed in the loop.
Exploring vacuum birefringence based on a 100 PW laser and an x-ray free electron laser beam
Shen, Baifei; Bu, Zhigang; Xu, Jiancai; Xu, Tongjun; Ji, Liangliang; Li, Ruxin; Xu, Zhizhan
2018-04-01
Exploring vacuum birefringence with the station of extreme light at Shanghai Coherent Light Facility is considered. Laser pulses of intensity beyond 1023 W cm-2 are capable of polarizing the vacuum due to the ultra-strong electro-magnetic fields. The subtle difference of the vacuum refractive indexes along electric and magnetic fields leads to a birefringence effect for lights propagating through. The vacuum birefringence effect can now be captured by colliding a hard x-ray free electron laser (XFEL) beam with a high-power laser. The initial XFEL beam of pure linear polarization is predicated to gain a very small ellipticity after passing through the laser stimulated vacuum. Various interaction geometries are considered, showing that the estimated ellipticity lies between 1.8 × 10-10 and 10-9 for a 100 PW laser interacting with a 12.9 keV XFEL beam, approaching the threshold for todays’ polarity detection technique. The detailed experimental set-up is designed, including the polarimeter, the focusing compound refractive lens and the optical path. When taking into account the efficiencies of the x-ray instruments, it is found that about 10 polarization-flipped x-ray photons can be detected for a single shot for our design. Considering the background noise level, accumulating runs are necessary to obtain high confident measurement.
LiTaO.sub.3./sub. crystals with near-zero birefringence
Czech Academy of Sciences Publication Activity Database
Glazier, A. M.; Zhang, N.; Bartasyte, A.; Keeble, D.S.; Huband, S.; Thomas, P.A.; Gregora, Ivan; Borodavka, Fedir; Margueron, S.; Hlinka, Jiří
2012-01-01
Roč. 45, č. 5 (2012), s. 1030-1037 ISSN 0021-8898 Institutional research plan: CEZ:AV0Z10100520 Keywords : lithium tantalate * birefringence * domains * Raman spectroscopy Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.343, year: 2012
DEFF Research Database (Denmark)
Tu, Haohua; Liu, Yuan; Liu, Xiaomin
2012-01-01
Dispersion-flattened dispersion-decreased all-normal dispersion (DFDD-ANDi) photonic crystal fibers have been identified as promising candidates for high-spectral-power coherent supercontinuum (SC) generation. However, the effects of the unintentional birefringence of the fibers on the SC generat...... of polarization-maintaining DFDD-ANDi fibers to avoid these adverse effects in pursuing a practical coherent fiber SC laser.......Dispersion-flattened dispersion-decreased all-normal dispersion (DFDD-ANDi) photonic crystal fibers have been identified as promising candidates for high-spectral-power coherent supercontinuum (SC) generation. However, the effects of the unintentional birefringence of the fibers on the SC...... generation have been ignored. This birefringence is widely present in nonlinear non-polarization maintaining fibers with a typical core size of 2 µm, presumably due to the structural symmetry breaks introduced in the fiber drawing process. We find that an intrinsic form-birefringence on the order of 10...
Distributed strain measurement using modal interference in a birefringent optical fiber
International Nuclear Information System (INIS)
Kumar, Dilip; Sengupta, S; Ghorai, S K
2008-01-01
We propose a method based on modal interference in a birefringent optical fiber for distributed strain measurement. A frequency-modulated optical signal from a laser diode was launched in a birefringent fiber whose 'V' number was set in the range 2.405–3.831. The beat signal produced due to the interference of two lower order modes LP 01 and LP 11 was detected in a photodetector. The change in propagation constants between two modes under loading conditions leads to a phase variation of interference signal. The amplitude of the beat frequency was measured in the frequency domain by varying the modulating frequency, and it provides the measurand distribution along the beam. Results for strain distribution of a simply supported beam (51.0 cm × 3.0 cm × 0.6 cm) for an applied load of 250–1500 g are presented
De Medeiros, R C G; Soares, J D; De Sousa, F B
2012-05-01
Lesion area measurement of enamel caries using polarized light microscopy (PLM) is currently performed in a large number of studies, but measurements are based mainly on a mislead qualitative interpretation of enamel birefringence in a single immersion medium. Here, five natural enamel caries lesions are analysed by microradiography and in PLM, and the differences in their histopathological features derived from a qualitative versus a quantitative interpretation of enamel birefringence are described. Enamel birefringence in different immersion media (air, water and quinoline) is interpreted by both qualitative and quantitative approaches, the former leading to an underestimation of the depth of enamel caries mainly when the criterion of validating sound enamel as a negatively birefringent area in immersion in water is used (a current common practice in dental research). Procedures to avoid the shortcomings of a qualitative interpretation of enamel birefringence are presented and discussed. © 2012 The Authors Journal of Microscopy © 2012 Royal Microscopical Society.
Helfer, Emmanuèle; Panine, Pierre; Carlier, Marie-France; Davidson, Patrick
2005-07-01
F-actin gels of increasing concentrations (25-300 microM) display in vitro a progressive onset of birefringence due to orientational ordering of actin filaments. At F-actin concentrations mechanical stresses stored in the gels. In contrast, at F-actin concentrations > or =100 microM, gels display spontaneous birefringence recovery, at rest, which is the sign of true nematic ordering, in good agreement with statistical physics models of the isotropic/nematic transition. Well-aligned samples of F-actin gels could be produced and their small-angle x-ray scattering patterns are quite anisotropic. These patterns show no sign of filament positional short-range order and could be modeled by averaging the form factor with the Maier-Saupe nematic distribution function. The derived nematic order parameter S of the gels ranged from S = 0.7 at 300 microM to S = 0.4 at 25 microM. Both birefringence and small-angle x-ray scattering data indicate that, even in absence of cross-linking proteins, spontaneous cooperative alignment of actin filaments may arise in motile regions of living cells where F-actin concentrations can reach values of a few 100 microM.
Directory of Open Access Journals (Sweden)
Fei Yu
2016-01-01
Full Text Available A novel high birefringence and nearly zero dispersion-flattened photonic crystal fiber (PCF with elliptical defected core (E-DC and equilateral pentagonal architecture is designed. By applying the full-vector finite element method (FEM, the characteristics of electric field distribution, birefringence, and chromatic dispersion of the proposed E-DC PCF are numerically investigated in detail. The simulation results reveal that the proposed PCF can realize high birefringence, ranging from 10-3 to 10-2 orders of magnitude, owing to the embedded elliptical air hole in the core center. However, the existence of the elliptical air hole gives rise to an extraordinary electric field distribution, where a V-shaped notch appears and the size of the V-shaped notch varies at different operating wavelengths. Also, the mode field diameter is estimated to be about 2 μm, which implies the small effective mode area and highly nonlinear coefficient. Furthermore, the investigation of the chromatic dispersion characteristic shows that the introduction of the elliptical air hole is helpful to control the chromatic dispersion to be negative or nearly zero flattened over a wide wavelength bandwidth.
Energy Technology Data Exchange (ETDEWEB)
Liu, Qingkun; Frazier, Allister W.; Zhao, Xinpeng; De La Cruz, Joshua A.; Hess, Andrew J.; Yang, Ronggui; Smalyukh, Ivan I.
2018-06-01
Experimental realization of optically transparent, mechanically robust and flexible aerogels has been a longstanding challenge, which limits their practical applications in energy-saving devices, such as thermally insulating films for enhancing energy efficiency of windows. The poor transparency precluded even hypothetical consideration of the possibility of birefringent aerogels. We develop birefringent and optically isotropic aerogels that combine properties of thermal super-insulation, mechanical robustness and flexibility, and transparency to visible-spectrum light. This unusual combination of physical properties is achieved by combining liquid crystalline self-organization of cellulose nanofibers with polysiloxane cross-linking and control of the nanoscale porosity to form hybrid organic-inorganic mesostructured aerogels. Potential applications of these inexpensive materials range from single pane window retrofitting to smart fabrics.
A polarisation modulation scheme for measuring vacuum magnetic birefringence with static fields
Energy Technology Data Exchange (ETDEWEB)
Zavattini, G.; Ejlli, A. [Universita di Ferrara, Dipt. di Fisica e Scienze della Terra (Italy); INFN, Sezione di Ferrara (Italy); Della Valle, F. [Universita di Trieste, Dipt. di Fisica, Trieste (Italy); INFN, Sezione di Trieste, TS (Italy); Ruoso, G. [INFN, Lab. Nazionali di Legnaro (Italy)
2016-05-15
A novel polarisation modulation scheme for polarimeters based on Fabry-Perot cavities is presented. The application to the measurement of the magnetic birefringence of vacuum with the HERA superconducting magnets in the ALPS-II configuration is discussed. (orig.)
Observation of ferroelastic domains in layered magnetic compounds using birefringence imaging
Miura, Yoko; Okumura, Kazuya; Manaka, Hirotaka
2018-03-01
The two-dimensional Heisenberg antiferromagnet (C2H5NH3)2CuCl4 is a candidate compound for the coexistence of ferroelectricity and ferroelasticity; however, the microscopic observations of multiferroic domains may still be unclear. In-plane birefringence imaging measurements were performed to observe the manner in which the ferroelectric and the ferroelastic domains change during phase transitions between 15 K and 300 K. It was found that 90° ferroelastic domains appeared in the ab-plane at 300 K. As the temperature decreased toward 15 K, each domain inverted at a certain temperature (T a) without structural or magnetic phase transitions. The value of T a was found to be significantly influenced by external stresses; therefore, birefringence imaging techniques are useful for investigating variations in ferroelastic domains with temperature. Furthermore, a structural phase transition from orthorhombic to monoclinic or triclinic occurred at 230 ~ 240 K; however, no spontaneous polarization appeared in the ab-plane over the entire investigated range.
Kawatsuki, Nobuhiro; Inada, Shogo; Fujii, Ryosuke; Kondo, Mizuho
2018-02-06
In situ formation of N-benzylideneaniline (NBA) side groups achieved photoinduced cooperative reorientation of photoinactive copolymers with phenylaldehyde (PA) and benzoic acid (BA) side groups doped with 4-methoxyaniline (AN) molecules. Thermally stimulated molecular reorientation of the side groups was generated due to the axis-selective photoreaction of the NBA moieties. Selective coating with AN on the copolymer film formed NBA moieties in the desired region, resulting in a photoinduced birefringent pattern. Additionally, postannealing at an elevated temperature for a long time attained photoinactivation of the reoriented film, and recoating with AN to form NBA achieved the multiple birefringent patterns and repatterning of the reoriented structures. The slow thermal hydrolysis of NBA, which was 50 times slower than the thermally stimulated self-organization of the side groups due to the presence of BA side groups, contributed to the photodurability of the reoriented film and multiple birefringent patterns.
Energy Technology Data Exchange (ETDEWEB)
Kurosaki, Yasuo; Satoh, Isao; Saito, Takushi [Tokyo Inst. of Tech. (Japan). Dept. of Mechanical Intelligent Systems Engineering
1995-12-31
Injection molding of polymers is currently utilized for numerous industrial applications. Because of high productivity and stable quality of molded products, the injection-molding process makes the production costs lower, and therefore, is expected to spread more widely in the future. This paper deals with a technique for improving the optical quality of injection molded polymer products using radiative heating. The birefringence frozen in a skin-layer of the molded part was reduced by CO{sub 2} laser heating, and the efficiency of this technique was investigated experimentally. Namely, a simple numerical calculation was performed to estimate the heating efficiency of CO{sub 2} laser in the polymer, effects of radiation heating on the skin-layer of the molded polymer were observed by using a mold with transparent windows, and the residual birefringence frozen in the final molded specimen was measured. The results clearly showed that the birefringence in the skin-layer of injection molded polymer strips was reduced with CO{sub 2} laser heating. The authors believe that the proposed method for reducing the birefringence frozen in injection-molded polymer products is suitable for practical molding, because process time required for the injection-molding is only slightly increased with this method.
DEFF Research Database (Denmark)
Naydenova, I; Nikolova, L; Ramanujam, P.S.
1999-01-01
We report the inducement of large circular birefringence (optical activity) in films of a cyanoazobenzene side-chain liquid-crystalline polyester on illumination with circularly polarized light. The polyester has no chiral groups and is initially isotropic. The induced optical rotation is up to 5...
A study of cooperative Jahn-Teller phase transitions in rare-earth vanadates by linear birefringence
International Nuclear Information System (INIS)
Gehring, G.A.; Harley, R.T.; Macfarlane, R.M.
1980-01-01
Changes in linear birefringence (Δn) associated with the cooperative Jahn-Teller phase transition of DyV04 near 14K as as a function of temperature and magnetic fields, B, between 0.024 and 0.095T have been measured. Theoretical arguments show that Δn is directly proportional to the order parameter of the transition and that B(2) is equivalent to the conjugate ordering field. By extrapolation to zero field the temperature dependence of the order parameter and the susceptibility were obtained. The data are compared with calculations based on a mean-field 'compressible' Ising model. For a reasonable choice of adjustable parameters this classical description gives a good fit to the data close to Tsub(D) consistent with general theoretical arguments and more detailed calculations, but it deviates progressively away from Tsub(D) presumably because of the known importance of short-range interactions in the system. (author)
Experiment to measure vacuum birefringence: Conceptual design
Mueller, Guido; Tanner, David; Doebrich, Babette; Poeld, Jan; Lindner, Axel; Willke, Benno
2016-03-01
Vacuum birefringence is another lingering challenge which will soon become accessible to experimental verification. The effect was first calculated by Euler and Heisenberg in 1936 and is these days described as a one-loop correction to the differential index of refraction between light which is polarized parallel and perpendicular to an external magnetic field. Our plan is to realize (and slightly modify) an idea which was originally published by Hall, Ye, and Ma using advanced LIGO and LISA technology and the infrastructure of the ALPS light-shining-through-walls experiment following the ALPS IIc science run. This work is supported by the Deutsche Forschungsgemeinschaft and the Heising-Simons Foundation.
The new PVLAS apparatus for detection of magnetic birefringence of vacuum
International Nuclear Information System (INIS)
Della Valle, F.; Di Domenico, G.; Gastaldi, U.; Milotti, E.; Messineo, G.; Pengo, R.; Piemontese, L.; Ruoso, G.; Zavattini, G.
2013-01-01
The PVLAS experiment aims at the observation and measurement of the effect of magnetic birefringence of vacuum (MBV) predicted by Quantum Electrodynamics. We describe here the new PVLAS apparatus which is currently being set up in INFN Ferrara. The apparatus features two rotating permanent dipole magnets and an ellipsometer operating under UHV with a high finesse Fabry–Perot cavity
Optical properties study of nano-composite filled D shape photonic crystal fibre
Directory of Open Access Journals (Sweden)
R. Udaiyakumar
2018-06-01
Full Text Available With the nano-composite materials gaining momentum in the optical field, a new nano-composite filled D shape Photonic Crystal Fiber (PCF is designed and the various optical properties are investigated with help of Finite Element Method. In the proposed structure the D-shape PCF is made up of silica with embedded silver nanoparticles and air holes are distributed along the fibre. The designed fibre shows various optical properties such as dispersion, birefringence, beat length and loss with respect to wavelength and compared with different filling factor like 0.1, 0.3 and 0.5. From our estimation and comparative analysis, it has been proved that the fibre loss has been decreased with increasing filling factor. Further this also showed flat dispersion at maximum filling factor. Keywords: Nanoparticles, Nano-composite, Dispersion, Birefringence, Beat length
DEFF Research Database (Denmark)
Cukras, Janusz; Kauczor, Joanna; Norman, Patrick
2016-01-01
A computational protocol for magneto-chiral dichroism and magneto-chiral birefringence dispersion is presented within the framework of damped response theory, also known as complex polarization propagator theory, at the level of time-dependent Hartree–Fock and time-dependent density functional th...
International Nuclear Information System (INIS)
Amjad, Jafar Mostafavi; Khalesifard, Hamid Reza; Slussarenko, Sergei; Karimi, Ebrahim; Santamato, Enrico; Marrucci, Lorenzo
2011-01-01
Samples of Ag + /Na + ion-exchanged glass that have been subject to intense laser irradiation may develop novel optical properties, as a consequence of the formation of patterns of silver nanoparticles and other structures. Here, we report the observation of a laser-induced permanent transverse birefringence, with the optical axis forming a radial pattern, as revealed by the spin-to-orbital angular momentum conversion occurring in a probe light beam. The birefringence pattern can be modeled well as resulting from thermally-induced stresses arising in the silver-doped glass during laser exposure, although the actual mechanism leading to the permanent anisotropy is probably more complex.
Directory of Open Access Journals (Sweden)
Alessandro Prudente
2016-06-01
Full Text Available ABSTRACT Objectives To describe acute and sub acute aspects of histological and immunohistochemical response to PP implant in a rat subcutaneous model based on objective methods. Materials and Methods Thirty rats had a PP mesh subcutaneously implanted and the same dissection on the other side of abdomen but without mesh (sham. The animals were euthanized after 4 and 30 days. Six slides were prepared using the tissue removed: one stained with hematoxylin-eosin (inflammation assessment; one unstained (birefringence evaluation and four slides for immunohistochemical processing: IL-1 and TNF-α (pro-inflammatory cytokines, MMP-2 (collagen metabolism and CD-31 (angiogenesis. The area of inflammation, the birefringence index, the area of immunoreactivity and the number of vessels were objectively measured. Results A larger area of inflammatory reaction was observed in PP compared to sham on the 4th and on the 30th day (p=0.0002. After 4 days, PP presented higher TNF (p=0.0001 immunoreactivity than sham and no differences were observed in MMP-2 (p=0.06 and IL-1 (p=0.08. After 30 days, a reduction of IL-1 (p=0.010 and TNF (p=0.016 for PP and of IL-1 (p=0.010 for sham were observed. Moreover, area of MMP-2 immunoreactivity decreased over time for PP group (p=0.018. Birefringence index and vessel counting showed no differences between PP and sham (p=0.27 and p=0.58, respectively. Conclusions The implantation of monofilament and macroporous polypropylene in the subcutaneous of rats resulted in increased inflammatory activity and higher TNF production in the early post implant phase. After 30 days, PP has similar cytokines immunoreactivity, vessel density and extracellular matrix organization.
Study of the Magnetically Induced QED Birefringence of the Vacuum in experiment OSQAR
AUTHOR|(CDS)2083980
Classical electrodynamics in a vacuum is a linear theory and does not foresee photon-photon scattering or other nonlinear effects between electromagnetic fields. In 1936 Euler, Heisenberg and Weisskopf put framework, in the earliest development of quantum electrodynamics (QED), that vacuum can behave as a birefringent medium in the presence of the external transverse magnetic field. This phenomenon is known as Vacuum Magnetic Birefringence (VMB) and it is still challenging for optical metrology since the first calculations in 1970. When linearly polarized light travels through the strong transverse magnetic field in vacuum, the polarization state of the light would change to elliptical. The difference in the refraction indexes of the ordinary and extraordinary ray is directly related to fundamental constants, such as fine structure constant or Compton wavelength. Contributions to VMB could also arise from the existence of light scalar or pseudoscalar particles, such as axions or axions like particles. Axions ...
Directory of Open Access Journals (Sweden)
Wen Zhao
2014-10-01
Full Text Available The B-mode polarization of the cosmic microwave background (CMB radiation is an excellent information channel for the detection of relic gravitational waves. However, the detection is contaminated by the B-mode polarization generated by some other effects. In this paper, we discuss the contaminations caused by the cosmological birefringence, which converts the CMB E-mode to the B-mode, and forms the effective noise for the detection of gravitational waves. We find that this contamination is significant, if the rotation angle is large. However, this kind of B-mode can be properly de-rotated, and the effective noises can be greatly reduced. We find that, comparing with the contaminations caused by cosmic weak lensing, the residual polarization generated by the cosmological birefringence is negligible for the detection of relic gravitational waves in the CMB.
International Nuclear Information System (INIS)
Taheri Qazvini, N.; Mohammadi, N.; Ghaffarian, R.; Assempour, H.; Haghighatkish, M.
2002-01-01
The effect of two important parameters of film blowing processes, i.e., take-up ration and blow-up ratio, on the overall orientation of low-density blown films have been investigated using birefringence measurements. Furthermore, by combining x-ray diffraction pole figure analysis and birefringence, the White and Spruiell biaxial orientation functions have been determined for aforementioned sample. Within the range of processing condition studied, increasing take-up ratio, increases orientation in both machine and transverse direction. Upon increasing blow-up ratio, orientation in the transverse direction increases and the overall orientation state approaches to equal biaxial one. Characterization of the crystalline regions by pole figure analysis reveals that a and b crystallographic axes preferentially orientate in the film plane and the direction normal to it, respectively. The amorphous regions do not have any preferential orientation
Wada, D.; Murayama, H.; Igawa, H.
2014-05-01
We investigate the capability of local birefringence detection in an embedded fiber Bragg grating (FBG) using optical frequency domain reflectometry. We embed an FBG into carbon fiber reinforced plastic specimen, and conduct 3-point bending test. The cross-sectional stresses are applied to the FBG at the loading location in addition to the non-uniform longitudinal strain distribution over the length of the FBG. The local birefringence due to the cross-sectional stresses was successfully detected while the non-uniform longitudinal strain distribution was accurately measured.
Isabettini, Stéphane; Baumgartner, Mirjam E; Fischer, Peter; Windhab, Erich J; Liebi, Marianne; Kuster, Simon
2018-01-03
Bicelles are tunable disk-like polymolecular assemblies formed from a large variety of lipid mixtures. Applications range from membrane protein structural studies by nuclear magnetic resonance (NMR) to nanotechnological developments including the formation of optically active and magnetically switchable gels. Such technologies require high control of the assembly size, magnetic response and thermal resistance. Mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and its lanthanide ion (Ln 3+ ) chelating phospholipid conjugate, 1,2-dimyristoyl-sn-glycero-3-phospho-ethanolamine-diethylene triaminepentaacetate (DMPE-DTPA), assemble into highly magnetically responsive assemblies such as DMPC/DMPE-DTPA/Ln 3+ (molar ratio 4:1:1) bicelles. Introduction of cholesterol (Chol-OH) and steroid derivatives in the bilayer results in another set of assemblies offering unique physico-chemical properties. For a given lipid composition, the magnetic alignability is proportional to the bicelle size. The complexation of Ln 3+ results in unprecedented magnetic responses in terms of both magnitude and alignment direction. The thermo-reversible collapse of the disk-like structures into vesicles upon heating allows tailoring of the assemblies' dimensions by extrusion through membrane filters with defined pore sizes. The magnetically alignable bicelles are regenerated by cooling to 5 °C, resulting in assembly dimensions defined by the vesicle precursors. Herein, this fabrication procedure is explained and the magnetic alignability of the assemblies is quantified by birefringence measurements under a 5.5 T magnetic field. The birefringence signal, originating from the phospholipid bilayer, further enables monitoring of polymolecular changes occurring in the bilayer. This simple technique is complementary to NMR experiments that are commonly employed to characterize bicelles.
Owiti, Edgar O.; Yang, Hanning; Liu, Peng; Ominde, Calvine F.; Sun, Xiudong
2018-02-01
Previous studies on hybrid dielectric-graphene metasurfaces have been used to implement induced transparency devices, while exhibiting high Q-factors based on trapped magnetic resonances. Typically, the transparency windows are single wavelength and less appropriate for polarization conversion structures. In this work, a quarter-wave plate based on a hybrid silicon-graphene metasurface with controllable birefringence is numerically designed. The phenomena of trapped magnetic mode resonance and high Q-factors are modulated by inserting graphene between silicon and silica. This results in a broader transmission wavelength in comparison to the all-dielectric structure without graphene. The birefringence tunability is based on the dimensions of silicon and the Fermi energy of graphene. Consequently, a linear-to-circular polarization conversion is achieved at a high degree of 96%, in the near-infrared. Moreover, the polarization state of the scattered light is switchable between right and left hand circular polarizations, based on an external gate biasing voltage. Unlike in plasmonic metasurfaces, these achievements demonstrate an efficient structure that is free from radiative and ohmic losses. Furthermore, the ultrathin thickness and the compactness of the structure are demonstrated as key components in realizing integrable and CMOS compatible photonic sensors.
Effect of birefringence of lens material on polarization status and optical imaging characteristics
Kim, Wan-Chin; Park, No-Cheol
2018-04-01
In most cases of molding with glass or optical polymers, it is expected that there will be birefringence caused by the internal mechanical stresses remaining in the molding material. The distribution of the residual stress can be annealed by slow cooling, but this approach is disadvantageous with respect to the shape accuracy and manufacturing time. In this study, we propose an analytical model to calculate the diffracted field near the focal plane by considering two primary parameters, the orientation angle of the fast axis and the path difference. In order to verify the reliability of the analytical model, we compared the measured beam spot of the F-theta lens of the laser scanning unit (LSU) with the analytical result. In addition, we analyzed the calculated result from the perspective of the polarization status in the exit pupil. The proposed analysis method can be applied to enhance the image quality for cases in which birefringence occurs in a lens material by suitably modeling the amplitude and phase of the incident light flux.
Energy Technology Data Exchange (ETDEWEB)
Sutter, John P., E-mail: john.sutter@diamond.ac.uk; Dolbnya, Igor P.; Collins, Stephen P. [Diamond Light Source Ltd, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE (United Kingdom); Harris, Kenneth D. M., E-mail: HarrisKDM@cardiff.ac.uk; Edwards-Gau, Gregory R.; Kariuki, Benson M. [School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT (United Kingdom); Palmer, Benjamin A. [Department of Structural Biology, Weizmann Institute of Science, 234 Herzl St., Rehovot 7610001 (Israel)
2016-07-27
Birefringence has been observed in anisotropic materials transmitting linearly polarized X-ray beams tuned close to an absorption edge of a specific element in the material. Synchrotron bending magnets provide X-ray beams of sufficiently high brightness and cross section for spatially resolved measurements of birefringence. The recently developed X-ray Birefringence Imaging (XBI) technique has been successfully applied for the first time using the versatile test beamline B16 at Diamond Light Source. Orientational distributions of the C–Br bonds of brominated “guest” molecules within crystalline “host” tunnel structures (in thiourea or urea inclusion compounds) have been studied using linearly polarized incident X-rays near the Br K-edge. Imaging of domain structures, changes in C–Br bond orientations associated with order-disorder phase transitions, and the effects of dynamic averaging of C–Br bond orientations have been demonstrated. The XBI setup uses a vertically deflecting high-resolution double-crystal monochromator upstream from the sample and a horizontally deflecting single-crystal polarization analyzer downstream, with a Bragg angle as close as possible to 45°. In this way, the ellipticity and rotation angle of the polarization of the beam transmitted through the sample is measured as in polarizing optical microscopy. The theoretical instrumental background calculated from the elliptical polarization of the bending-magnet X-rays, the imperfect polarization discrimination of the analyzer, and the correlation between vertical position and photon energy introduced by the monochromator agrees well with experimental observations. The background is calculated analytically because the region of X-ray phase space selected by this setup is sampled inefficiently by standard methods.
Nonlinear polarization effects in a birefringent single mode optical fiber
International Nuclear Information System (INIS)
Ishiekwene, G.C.; Mensah, S.Y.; Brown, C.S.
2001-04-01
The nonlinear polarization effects in a birefringent single mode optical fiber is studied using Jacobi elliptic functions. We find that the polarization state of the propagating beam depends on the initial polarization as well as the intensity of the input light in a complicated way. The Stokes polarization parameters are either periodic or aperiodic depending on the value of the Jacobian modulus. Our calculations suggest that the effective beat length of the fiber can become infinite at a higher critical value of the input power when polarization dependent losses are considered. (author)
International Nuclear Information System (INIS)
Bastwoeste, K.; Schwalenberg, S.; Baeumer, Ch.; Kraetzig, E.
2003-01-01
Iron-doped lithium-tantalate samples with different compositions ranging from the congruently melting to the stoichiometric one are analyzed by anisotropic holographic scattering. The temperature dependence of the birefringence yields information on the composition of the crystals. (copyright 2003 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)
Energy Technology Data Exchange (ETDEWEB)
Bastwoeste, K.; Schwalenberg, S.; Baeumer, Ch.; Kraetzig, E. [Fachbereich Physik, Universitaet Osnabrueck, D-49069 Osnabrueck (Germany)
2003-09-01
Iron-doped lithium-tantalate samples with different compositions ranging from the congruently melting to the stoichiometric one are analyzed by anisotropic holographic scattering. The temperature dependence of the birefringence yields information on the composition of the crystals. (copyright 2003 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)
Directory of Open Access Journals (Sweden)
Clint Zeringue
2010-01-01
Full Text Available A technique to tune a magnetic quasi-phase matching in-fiber isolator through the application of stress induced by two mutually orthogonal capillary tubes filled with liquid ethanol is investigated numerically. The results show that it is possible to “tune” the birefringence in these fibers over a limited range depending on the temperature at which the ethanol is loaded into the capillaries. Over this tuning range, the thermal sensitivity of the birefringence is an order-of-magnitude lower than conventional fibers, making this technique well suited for magnetic quasi-phase matching.
DEFF Research Database (Denmark)
Habib, Selim; Khandker, Emran
2015-01-01
We present a new cladding design for photonic crystal fiber (PCF) on a decagonal structure to simultaneously achieve ultra-flattened large negative dispersion and ultrahigh birefringence. Numerical results confirm that the proposed PCFexhibits ultra-flattened large negative dispersion over the S ...
Arabanian, Atoosa Sadat; Najafi, Somayeh; Ajami, Aliasghar; Husinsky, Wolfgang; Massudi, Reza
2018-02-01
We have succeeded in realizing a method to control the spatial distribution of optical retardation as a result of nanogratings in bulk-fused silica induced by ultrashort laser pulses. A colorimetry-based retardation measurement (CBRM) based on the Michel-Levy interference color chart using a polarization microscope is used to determine the profiles of the optical retardation. Effects of the spatial overlap of written regions as well as the energy and polarization of the writing pulses on the induced retardations are studied. It has been found that the spatial overlap of lines written by pulse trains with different energies and polarizations can result in an adjustment of the induced birefringence in the overlap region. This approach offers the possibility of designing polarization-sensitive components with a desired birefringence profile.
International Nuclear Information System (INIS)
Ishiekwene, G.C.; Brown, C.S.; Mensah, S.Y.; Bak, A.E.
2000-07-01
A theoretical analysis on the polarization effects of a light beam propagating in a birefringent single-mode fiber is presented. We derive a system of differential equations representing the evolution of Stokes parameters and illustrate their application to polarization effects in a straight birefringent single mode optical fiber. The solutions to the set of equations are obtained using specifically the methods of the unified formalism for polarization optics which adopt the use of the Stokes-Mueller equation and the Lorentz group to model polarization phenomena in media such as optical fibers. The analytical results presented using this approach are identical to results obtained from other conventional methods. We observe the characteristic exponential decrease in the total intensity of the input light due to attenuation by the fiber. (author)
Zhu, Mengshi; Murayama, Hideaki
2017-04-01
New approach in simultaneous measurement of dynamic strain and temperature has been done by using a high birefringence PANDA fiber Bragg grating sensor. By this technique, we have succeeded in discriminating dynamic strain and temperature distribution at the sampling rate of 800 Hz and the spatial resolution of 1 mm. The dynamic distribution of strain and temperature were measured with the deviation of 5mm spatially. In addition, we have designed an experimental setup by which we can apply quantitative dynamic strain and temperature distribution to the fiber under testing without bounding it to a specimen.
Viscosity and transient electric birefringence study of clay colloidal aggregation.
Bakk, Audun; Fossum, Jon O; da Silva, Geraldo J; Adland, Hans M; Mikkelsen, Arne; Elgsaeter, Arnljot
2002-02-01
We study a synthetic clay suspension of laponite at different particle and NaCl concentrations by measuring stationary shear viscosity and transient electrically induced birefringence (TEB). On one hand the viscosity data are consistent with the particles being spheres and the particles being associated with large amount bound water. On the other hand the viscosity data are also consistent with the particles being asymmetric, consistent with single laponite platelets associated with a very few monolayers of water. We analyze the TEB data by employing two different models of aggregate size (effective hydrodynamic radius) distribution: (1) bidisperse model and (2) log-normal distributed model. Both models fit, in the same manner, fairly well to the experimental TEB data and they indicate that the suspension consists of polydisperse particles. The models also appear to confirm that the aggregates increase in size vs increasing ionic strength. The smallest particles at low salt concentrations seem to be monomers and oligomers.
Provenzano, Clementina; Pagliusi, Pasquale; Cipparrone, Gabriella; Royes, Jorge; Piñol, Milagros; Oriol, Luis
2014-10-09
Light-controlled molecular alignment is a flexible and useful strategy introducing novelty in the fields of mechanics, self-organized structuring, mass transport, optics, and photonics and addressing the development of smart optical devices. Azobenzene-containing polymers are well-known photocontrollable materials with large and reversible photoinduced optical anisotropies. The vectorial holography applied to these materials enables peculiar optical devices whose properties strongly depend on the relative values of the photoinduced birefringences. Here is reported a polarization holographic recording based on the interference of two waves with orthogonal linear polarization on a bifunctional amorphous polymer that, exceptionally, exhibits equal values of linear and circular birefringence. The peculiar photoresponse of the material coupled with the holographic technique demonstrates an optical device capable of decomposing the light into a set of orthogonally polarized linear components. The holographic structures are theoretically described by the Jones matrices method and experimentally investigated.
Sutter, John P.; Dolbnya, Igor P.; Collins, Stephen P.; Harris, Kenneth D. M.; Edwards-Gau, Gregory R.; Palmer, Benjamin A.
2015-04-01
In the recently developed technique of X-ray Birefringence Imaging, molecular orientational order in anisotropic materials is studied by exploiting the birefringence of linearly polarized X-rays with energy close to an absorption edge of an element in the material. In the experimental setup, a vertically deflecting high-resolution double-crystal monochromator is used upstream from the sample to select the appropriate photon energy, and a horizontally deflecting X-ray polarization analyzer, consisting of a perfect single crystal with a Bragg reflection at Bragg angle of approximately 45°, is placed downstream from the sample to measure the resulting rotation of the X-ray polarization. However, if the experiment is performed on a synchrotron bending-magnet beamline, then the elliptical polarization of the X-rays out of the electron orbit plane affects the shape of the output beam. Also, because the monochromator introduces a correlation between vertical position and photon energy to the X-ray beam, the polarization analyzer does not select the entire beam, but instead selects a diagonal stripe, the slope of which depends on the Bragg angles of the monochromator and the polarization analyzer. In the present work, the final background intensity distribution is calculated analytically because the phase space sampling methods normally used in ray traces are too inefficient for this setup. X-ray Birefringence Imaging data measured at the Diamond Light Source beamline B16 agree well with the theory developed here.
Energy Technology Data Exchange (ETDEWEB)
Sutter, John P., E-mail: john.sutter@diamond.ac.uk; Dolbnya, Igor P.; Collins, Stephen P. [Diamond Light Source Ltd., Chilton, Didcot, Oxfordshire OX11 0DE (United Kingdom); Harris, Kenneth D. M.; Edwards-Gau, Gregory R. [School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, Wales (United Kingdom); Palmer, Benjamin A. [Department of Structural Biology, Weizmann Institute of Science, 234 Herzl St., Rehovot 7610001 (Israel)
2015-04-28
In the recently developed technique of X-ray Birefringence Imaging, molecular orientational order in anisotropic materials is studied by exploiting the birefringence of linearly polarized X-rays with energy close to an absorption edge of an element in the material. In the experimental setup, a vertically deflecting high-resolution double-crystal monochromator is used upstream from the sample to select the appropriate photon energy, and a horizontally deflecting X-ray polarization analyzer, consisting of a perfect single crystal with a Bragg reflection at Bragg angle of approximately 45°, is placed downstream from the sample to measure the resulting rotation of the X-ray polarization. However, if the experiment is performed on a synchrotron bending-magnet beamline, then the elliptical polarization of the X-rays out of the electron orbit plane affects the shape of the output beam. Also, because the monochromator introduces a correlation between vertical position and photon energy to the X-ray beam, the polarization analyzer does not select the entire beam, but instead selects a diagonal stripe, the slope of which depends on the Bragg angles of the monochromator and the polarization analyzer. In the present work, the final background intensity distribution is calculated analytically because the phase space sampling methods normally used in ray traces are too inefficient for this setup. X-ray Birefringence Imaging data measured at the Diamond Light Source beamline B16 agree well with the theory developed here.
DEFF Research Database (Denmark)
Gu, Bobo; Yuan, Wu; He, Sailing
2012-01-01
We demonstrate a temperature compensated strain sensor with two cascaded Sagnac interferometers, that provide strain sensing and temperature compensation, respectively. The Sagnac interferometers use an all-solid hybrid photonic crystal fiber with stress-induced birefringence. The stress-induced ...
Adams, David C.; Hariri, Lida P.; Holz, Jasmin A.; Szabari, Margit V.; Harris, R. Scott; Cho, Jocelyn L.; Hamilos, Daniel L.; Luster, Andrew D.; Medoff, Benjamin D.; Suter, Melissa J.
2016-03-01
The ability to observe airway dynamics is fundamental to forming a complete understanding of pulmonary diseases such as asthma. We have previously demonstrated that Optical Coherence Tomography (OCT) can be used to observe structural changes in the airway during bronchoconstriction, but standard OCT lacks the contrast to discriminate airway smooth muscle (ASM) bands- ASM being responsible for generating the force that drives airway constriction- from the surrounding tissue. Since ASM in general exhibits a greater degree of birefringence than the surrounding tissue, a potential solution to this problem lies in the implementation of polarization sensitivity (PS) to the OCT system. By modifying the OCT system so that it is sensitive to the birefringence of tissue under inspection, we can visualize the ASM with much greater clarity and definition. In this presentation we show that the force of contraction can be indirectly measured by an associated increase in the birefringence signal of the ASM. We validate this approach by attaching segments of swine trachea to an isometric force transducer and stimulating contraction, while simultaneously measuring the exerted force and imaging the segment with PS-OCT. We then show how our results may be used to extrapolate the force of contraction of closed airways in absence of additional measurement devices. We apply this technique to assess ASM contractility volumetrically and in vivo, in both asthmatic and non-asthmatic human volunteers.
International Nuclear Information System (INIS)
Power, J.G.; Jing, C.
2009-01-01
We report experimental investigations into a new technique for achieving temporal laser pulse shaping for RF photocathode gun applications using inexpensive UV birefringent crystals. Exploiting the group velocity mismatch between the two different polarizations of a birefringent crystal, a stack of UV pulses can be assembled into the desired temporal pulse shape. The scheme is capable of generating a variety of temporal pulse shapes including: (i) flat-top pulses with fast rise-time and variable pulse duration. (ii) microbunch trains, and (iii) ramped pulse generation. We will consider two applications for beam generation at the Argonne Wakefield Accelerator (AWA) including a flat-top laser pulse for low emittance production and matched bunch length for enhanced transformer ratio production. Streak camera measurements of the temporal profiles generated with a 2-crystal set and a 4-crystal set are presented.
Calculation of the mean differential group delay of periodically spun, randomly birefringent fibers
Galtarossa, Andrea; Griggio, Paola; Pizzinat, Anna; Palmieri, Luca
2002-05-01
Spinning is one of the most effective and well-known ways to reduce polarization mode dispersion of optical fibers. In spite of the popularity of spinning, a detailed theory of spin effects is still lacking. We report an analytical expression for the mean differential group delay of a randomly birefringent spun fiber. The result holds for any periodic spin function with a period shorter than the fiber's beat length.
Roy, Aradhana; Pathak, Govind; Herman, Jakub; Inamdar, Sanjeev R.; Srivastava, Atul; Manohar, Rajiv
2018-03-01
The present study investigates the influence of InP/ZnS core/shell QDs on various parameters of Nematic LC sample 1832A, based on 4-(4-alkyl-cyclohexyl)benzene isothiocyanates and 4-(4-alkyl-cyclohexyl)biphenyl isothiocyanates. Observations recorded consist of distinguished functioning of birefringence phenomenon along with characteristic response time measurement. Further study of rotational viscosity and splay elastic constant portrays stupendous behavior strengthening the appositeness of the composites for low-charge consumable devices. The addition of 0.2 ml of core/shell QDs producing more than two times faster response and enhanced birefringence at low-temperature range can be employed in development of thermostable photonic devices. In addition, dielectric properties comprising of relative permittivity and conductivity have been reported supporting the outcome of the investigation in applicative LC-based technologies.
Compensation for thermally induced birefringence in polycrystalline ceramic active elements
International Nuclear Information System (INIS)
Kagan, M A; Khazanov, E A
2003-01-01
Polycrystalline ceramics differ significantly from single crystals in that the crystallographic axes (and hence of the axes of thermally induced birefringence) are oriented randomly in each granule of the ceramic. The quaternion formalism is employed to calculate the depolarisation in the ceramics and the efficiency of its compensation. The obtained analytic expressions are in good agreement with the numerical relations. It is shown that the larger the ratio of the sample length to the granule size, the closer the properties of the ceramics to those of a single crystal with the [111] orientation (in particular, the uncompensated depolarisation is inversely proportional to this ratio). (active media)
Strong optical feedback in birefringent dual frequency laser
Institute of Scientific and Technical Information of China (English)
Mao Wei; Zhang Shu-Lian
2006-01-01
Strong optical feedback in a birefringent dual frequency He-Ne laser with a high reflectivity feedback mirror has been investigated for the first time. The output characteristics of two orthogonally polarized modes are demonstrated in two different optical feedback cases: one is for both modes being fed back and the other is for only one of the modes being fed back. Strong mode competition can be observed between the two modes with strong optical feedback. And when one mode's intensity is near its maximum, the other mode is nearly extinguished. When both modes are fed back into the laser cavity, the mode competition is stronger than when only one mode is fed back. The difference in initial intensity between the two orthogonally polarized modes plays an important role in the mode competition, which has been experimentally and theoretically demonstrated.
Vacuum birefringence and the x-ray polarization from black-hole accretion disks
Caiazzo, Ilaria; Heyl, Jeremy
2018-04-01
In the next decade, x-ray polarimetry will open a new window on the high-energy Universe, as several missions that include an x-ray polarimeter are currently under development. Observations of the polarization of x rays coming from the accretion disks of stellar-mass and supermassive black holes are among the new polarimeters' major objectives. In this paper, we show that these observations can be affected by the quantum electrodynamic (QED) effect of vacuum birefringence: after an x-ray photon is emitted from the accretion disk, its polarization changes as the photon travels through the accretion disk's magnetosphere, as a result of the vacuum becoming birefringent in the presence of a magnetic field. We show that this effect can be important for black holes in the energy band of the upcoming polarimeters and has to be taken into account in a complete model of the x-ray polarization that we expect to detect from black-hole accretion disks, both for stellar mass and for supermassive black holes. We find that, for a chaotic magnetic field in the disk, QED can significantly decrease the linear polarization fraction of edge-on photons, depending on the spin of the hole and on the strength of the magnetic field. This effect can provide, for the first time, a direct way to probe the magnetic field strength close to the innermost stable orbit of black-hole accretion disks and to study the role of magnetic fields in astrophysical accretion in general.
Pump Spectral Bandwidth, Birefringence, and Entanglement in Type-II Parametric Down Conversion
Directory of Open Access Journals (Sweden)
Daniel Erenso
2009-01-01
Full Text Available The twin photons produced by a type-II spontaneous parametric down conversion are well know as a potential source of photons for quantum teleportation due to the strong entanglement in polarization. This strong entanglement in polarization, however, depends on the spectral composition of the pump photon and the nature of optical isotropy of the crystal. By exact numerical calculation of the concurrence, we have shown that how pump photons spectral width and the birefringence nature of the crystal directly affect the degree of polarization entanglement of the twin photons.
Design of low-loss and highly birefringent hollow-core photonic crystal fiber
DEFF Research Database (Denmark)
Roberts, Peter John; Williams, D.P.; Sabert, H.
2006-01-01
A practical hollow-core photonic crystal fiber design suitable for attaining low-loss propagation is analyzed. The geometry involves a number of localized elliptical features positioned on the glass ring that surrounds the air core and separates the core and cladding regions. The size of each...... feature is tuned so that the composite core-surround geometry is antiresonant within the cladding band gap, thus minimizing the guided mode field intensity both within the fiber material and at material / air interfaces. A birefringent design, which involves a 2-fold symmetric arrangement of the features...
Energy Technology Data Exchange (ETDEWEB)
Estudillo-Ayala, J. M.; Kuzin, E. A.; Ibarra-Escamilla, B. [Instituto Nacional de Astrofisica, Optica y Electronica, Puebla (Mexico); Rojas-Laguna, R. [Universidad de Guanajuato, Guanajuato (Mexico)
2001-06-01
The fibre Sagnac interferometer of low birefringence and twist in the lineal region is examined numerically, a method is shown to measure the birefringence in the fibers and rotation of the axes inside of the interferometer fibre loop. [Spanish] El interferometro de Sagnac de fibra de baja birrefrigencia y torcida en la region lineal es numericamente examinado, se muestra un metodo para medir la birrefrigencia en las fibras y rotacion de los ejes dentro de la fibra del lazo del interferometro.
Directory of Open Access Journals (Sweden)
C. W. Su
2013-07-01
Full Text Available An experimental approach of inclined incidence magneto-optic Faraday effect observed in the polar plane is applied. Three samples containing ferromagnetic cobalt ultrathin films on a semiconductor zinc oxide (0001 single crystal substrate with in-plane and out-of-plane anisotropy are evaluated. Through the fine adjustment of crossed polarizers in the magneto-optic effect measurement completely recorded the detail optical and magneto-optical responses from the birefringent crystal substrate and the magnetic film, especially for the signal induced from the substrate with uniaxial optical axis. The angle dependency of interference phenomena periodically from the optical and magneto-optical responses is attributed to the birefringence even in the absence of a magnetic field. The new type of observation finds that the transmission Faraday intensity in the oblique incidence includes a combination of polarization rotations, which results from optical compensation from the substrate and magneto-optical Faraday effects from the film. The samples grown at different rates and examined by this method exhibit magnetic structure discriminations. This result can be applied in the advanced polarized-light technologies to enhance the spatial resolution of magnetic surfaces with microstructural information under various magnetic field direction.
Polarization holographic recording in Disperse Red1 doped polyurethane polymer film
Energy Technology Data Exchange (ETDEWEB)
Aleksejeva, J; Gerbreders, A; Gertners, U; Reinfelde, M; Teteris, J, E-mail: aleksejeva.jelena@gmail.com [Institute of Solid State Physics, University of Latvia, Kengaraga street 8, Riga (Latvia)
2011-06-23
In this report holographic recording of polarisation and surface relief gratings in Disperse Red 1 (DR1) doped polyurethane polymer films was studied. In this material DR1 is chemically bounded to polyurethane polymer main chain. Polarization holographic recording was performed by two orthogonal circularly polarized 532 nm laser beams. Photoinduced birefringence is a precondition for polarization holograms recording, therefore a detailed study of a photoinduced birefringence and changes of optical properties was performed. The lasers with wavelengths of 375nm, 448nm, 532 nm and 632.8 nm were used as pumping beam for sample excitation. The photoinduced birefringence {Delta}n was measured at 532 nm and 632.8 nm wavelengths. The photoinduced birefringence dependence on the pumping beam wavelength and intensity was investigated. Surface relief grating (SRG) formation was observed during polarization holographic recording process. A profile of SRG was studied by AFM. A relationship between SRG formation and photoinduced birefringence has been discussed.
Energy Technology Data Exchange (ETDEWEB)
Frins, E [Universidad de la Republica, Montevideo (Uruguay); Dultz, W [J.W.v.Goethe Universitaet Frankfurt/Main (Germany); Schmitzer, H, E-mail: requalivahanus@t-online.de [Xavier University, Cincinnati (United States)
2011-01-01
Rotating small birefringent particles with the spin angular momentum of light is a key experiment of quantum optics. We derive the equation of motion of small retarders in viscose liquids, demonstrate their some times irregular rotation in polarized light, and discuss possible technical applications.
Birefringence of single and bundled microtubules.
Oldenbourg, R; Salmon, E D; Tran, P T
1998-01-01
We have measured the birefringence of microtubules (MTs) and of MT-based macromolecular assemblies in vitro and in living cells by using the new Pol-Scope. A single microtubule in aqueous suspension and imaged with a numerical aperture of 1.4 had a peak retardance of 0.07 nm. The peak retardance of a small bundle increased linearly with the number of MTs in the bundle. Axonemes (prepared from sea urchin sperm) had a peak retardance 20 times higher than that of single MTs, in accordance with the nine doublets and two singlets arrangement of parallel MTs in the axoneme. Measured filament retardance decreased when the filament was defocused or the numerical aperture of the imaging system was decreased. However, the retardance "area," which we defined as the image retardance integrated along a line perpendicular to the filament axis, proved to be independent of focus and of numerical aperture. These results are in good agreement with a theory that we developed for measuring retardances with imaging optics. Our theoretical concept is based on Wiener's theory of mixed dielectrics, which is well established for nonimaging applications. We extend its use to imaging systems by considering the coherence region defined by the optical set-up. Light scattered from within that region interferes coherently in the image point. The presence of a filament in the coherence region leads to a polarization dependent scattering cross section and to a finite retardance measured in the image point. Similar to resolution measurements, the linear dimension of the coherence region for retardance measurements is on the order lambda/(2 NA), where lambda is the wavelength of light and NA is the numerical aperture of the illumination and imaging lenses.
Birefringence imaging of phase transitions: application to Na0.5Bi0.5TiO3
International Nuclear Information System (INIS)
Geday, M.; Kreisel, J.; Glazer, A.M.; Roleder, K.
2000-01-01
In recent years a number of imaging techniques to determine the optical properties of materials, either in reflection or in transmission, have been developed. Here the use of an imaging version of the so-called rotating-polarizer method in the study of phase transformations in crystals is demonstrated. This method creates false-coloured images representing the light transmission I 0 , the extinction angle φ (orientation of the optical indicatrix) and vertical stroke sin δ vertical stroke, a function of the retardation resulting from the birefringence (and a measure of the magnitude of optical anisotropy). When combined with a computer-controlled heating stage, this method provides an opportunity to create separate moving images of orientation and magnitude of optical anisotropy, showing the dynamics of twinning and domain-wall behaviour during temperature changes. It is believed that this is the first time that quantitative imaging of changes in birefringence has been used in this way to describe phase transitions. Two-phase transitions in a crystal of Na 0.5 Bi 0.5 TiO 3 (NBT) are presented as examples of the use of the system. (orig.)
Precise and versatile formula for birefringent filters
Shao, Zhongxing
1996-07-01
In an investigation of extraordinary-(E-) ray behavior and the index of refraction for E waves in a uniaxial crystal, a precise and versatile formula for birefringent filters, based on the exact construction of the optical path difference, is set up with neither the approximation Delta n = no - ne less than or equals no (or n e), nor the ambiguity sin( theta )/sin(rw) = ne. The exact construction gives the correct variation of the position and the dimension in each path, yielding the path difference while the filter is tuning. The formula is applicable not only to a filter with its optical axis parallel to the entrance surface (FAPS) but also to a filter with its axis inclined to the surface (FAIS). Also, the formula indicates that a FAIS allows laser wavelengths to be tuned over a wider range than does a FAPS. The origin of the wider range is interpreted to be the greater variation in the index for the FAIS while the filter is tuning. With the help of the formula we design a FAIS for tuning a cw 42.25.Lc.
2015-01-01
Background Selection of the best oocyte for subsequent steps of fertilization and embryo transfer was shown to be the crucial step in human infertility treatment procedure. Oocyte selection using morphological criteria mainly Zona pellucida (ZP) has been the gold standard method in assisted reproductive technologies (ART) clinics, but this selection approach has limitations in terms of accuracy, objectivity and constancy. Recent studies using OMICs-based approaches have allowed the identification of key molecular markers that quantitatively and non-invasively predict the oocyte quality for higher pregnancy rates and efficient infertility treatment. These biomarkers are a valuable reinforcement of the morphological selection criteria widely used in in vitro fertilization (IVF) clinics. In this context, this study was designed to investigate the relationship between transcriptomic predictors of oocyte quality found by our group and the conventional morphological parameters of oocyte quality mainly the ZP birefringence. Results Microarray data revealed that 48 and 27 differentially expressed candidate genes in cumulus cells (CCs) were respectively overexpressed and underexpressed in the ZGP (Zona Good Pregnant) versus ZBNP (Zona Bad Non Pregnant) groups. More than 70% of previously reported transcriptomic biomarkers of oocyte developmental competence were confirmed in this study. The analysis of possible association between ZP birefringence versus molecular markers approach showed an absence of correlation between them using the current set of markers. Conclusions This study suggested a new integrative approach that matches morphological and molecular approaches used to select developmentally competent oocytes able to lead to successful pregnancy and the delivery of healthy baby. For each ZP birefringence score, oocytes displayed a particular CCs' gene expression pattern. However, no correlations were found between the 7 gene biomarkers of oocyte developmental
Investigations on birefringence effects in polymer optical fiber Bragg gratings
DEFF Research Database (Denmark)
Hu, Xiaolian; Saez-Rodriguez, D.; Bang, Ole
2014-01-01
Step-index polymer optical fiber Bragg gratings (POFBGs) and microstructured polymer optical fiber Bragg gratings (mPOFBGs) present several attractive features, especially for sensing purposes. In comparison to FBGs written in silica fibers, they are more sensitive to temperature and pressure...... because of the larger thermo-optic coefficient and smaller Young's modulus of polymer materials. (M)POFBGs are most often photowritten in poly(methylmethacrylate) (PMMA) materials using a continuous-wave 325 nm HeCd laser. For the first time to the best of our knowledge, we study photoinduced...... birefringence effects in (m)POFBGs. To achieve this, highly reflective gratings were inscribed with the phase mask technique. They were then monitored in transmission with polarized light. For this, (m)POF sections a few cm in length containing the gratings were glued to angled silica fibers. Polarization...
Petersen, Claudia G; Vagnini, Laura D; Mauri, Ana L; Massaro, Fabiana C; Silva, Liliane F I; Cavagna, Mario; Baruffi, Ricardo L R; Oliveira, Joao B A; Franco, José G
2011-04-23
This study evaluated whether there is a relationship between the zona pellucida birefringence (ZP-BF) intensity and the nuclear (NM) and cytoplasmic (CM) in vitro maturation of human oocytes from stimulated cycles. The ZP-BF was evaluated under an inverted microscope with a polarizing optical system and was scored as high/positive (when the ZP image presented a uniform and intense birefringence) or low/negative (when the image presented moderate and heterogeneous birefringence). CM was analyzed by evaluating the distribution of cortical granules (CGs) throughout the ooplasm by immunofluorescence staining. CM was classified as: complete, when CG was localized in the periphery; incomplete, when oocytes presented a cluster of CGs in the center; or in transition, when oocytes had both in clusters throughout cytoplasm and distributed in a layer in the cytoplasm periphery Nuclear maturation: From a total of 83 germinal vesicle (GV) stage oocytes, 58 of oocytes (69.9%) reached NM at the metaphase II stage. From these 58 oocytes matured in vitro, the high/positively scoring ZP-BF was presented in 82.7% of oocytes at the GV stage, in 75.8% of oocytes when at the metaphase I, and in 82.7% when oocytes reached MII. No relationship was observed between NM and ZP-BF positive/negative scores (P = 0.55). These variables had a low Pearson's correlation coefficient (r = 0.081). Cytoplasmic maturation: A total of 85 in vitro-matured MII oocytes were fixed for CM evaluation. Forty-nine oocytes of them (57.6%) showed the complete CM, 30 (61.2%) presented a high/positively scoring ZP-BF and 19 (38.8%) had a low/negatively scoring ZP-BF. From 36 oocytes (42.3%) with incomplete CM, 18 (50%) presented a high/positively scoring ZPBF and 18 (50%) had a low/negatively scoring ZP-BF. No relationship was observed between CM and ZP-BF positive/negative scores (P = 0.42). These variables had a low Pearson's correlation coefficient (r = 0.11). The current study demonstrated an absence of
Directory of Open Access Journals (Sweden)
Silva Liliane FI
2011-04-01
Full Text Available Abstract Background This study evaluated whether there is a relationship between the zona pellucida birefringence (ZP-BF intensity and the nuclear (NM and cytoplasmic (CM in vitro maturation of human oocytes from stimulated cycles. Results The ZP-BF was evaluated under an inverted microscope with a polarizing optical system and was scored as high/positive (when the ZP image presented a uniform and intense birefringence or low/negative (when the image presented moderate and heterogeneous birefringence. CM was analyzed by evaluating the distribution of cortical granules (CGs throughout the ooplasm by immunofluorescence staining. CM was classified as: complete, when CG was localized in the periphery; incomplete, when oocytes presented a cluster of CGs in the center; or in transition, when oocytes had both in clusters throughout cytoplasm and distributed in a layer in the cytoplasm periphery Nuclear maturation: From a total of 83 germinal vesicle (GV stage oocytes, 58 of oocytes (69.9% reached NM at the metaphase II stage. From these 58 oocytes matured in vitro, the high/positively scoring ZP-BF was presented in 82.7% of oocytes at the GV stage, in 75.8% of oocytes when at the metaphase I, and in 82.7% when oocytes reached MII. No relationship was observed between NM and ZP-BF positive/negative scores (P = 0.55. These variables had a low Pearson's correlation coefficient (r = 0.081. Cytoplasmic maturation: A total of 85 in vitro-matured MII oocytes were fixed for CM evaluation. Forty-nine oocytes of them (57.6% showed the complete CM, 30 (61.2% presented a high/positively scoring ZP-BF and 19 (38.8% had a low/negatively scoring ZP-BF. From 36 oocytes (42.3% with incomplete CM, 18 (50% presented a high/positively scoring ZPBF and 18 (50% had a low/negatively scoring ZP-BF. No relationship was observed between CM and ZP-BF positive/negative scores (P = 0.42. These variables had a low Pearson's correlation coefficient (r = 0.11. Conclusions The current
International Nuclear Information System (INIS)
Manaka, Hirotaka; Nozaki, Hirofumi; Miura, Yoko
2017-01-01
Phase transitions in SrTiO 3 between quantum paraelectric, coherent paraelectric, and electric-field-induced ferroelectric states are governed by tetragonal domains with quantum fluctuations. However, their characteristics are still unclear. To observe the electric-field-induced ferroelectric state using birefringence imaging techniques, we developed a suitable sample holder to apply high electric fields of up to E ≃ 5 kV/cm and temperatures down to T = 20 K. From birefringence imaging measurements of the ferroelectric LiNbO 3 with varying electric field, distributions of the electric field in the sample stage were found to be negligible. In SrTiO 3 , a huge-retardance area corresponding to the ferroelectric domains appears at E > 2 kV/cm and T ≤ 60 K even though the paraelectric domains partially remain. Furthermore, the fast-axis direction rotates by 90° at the ferroelectric phase transition because of an electrostrictive effect in ferroelectrics. The phase diagram of the critical electric field and temperature agrees with previous reports obtained from dielectric and neutron scattering measurements. (author)
Experimental study on birefringence effect in high-tension bolts
International Nuclear Information System (INIS)
Kim, No You; Lee, Sang Soon; Jang, Kyung Young
2005-01-01
Bolts widely used in machine parts and assemblies are pre-loaded to prevent the parts from separating and to maintain the strength of the assemblies. Conventional technique for measurement of this axial stress applied to bolts is torque meter, but it has two disadvantages. The first one is its inherent inaccuracy. The second is that the stress cannot be determined after assembly without twisting bolts. The most promising technique for measurement of the axial stress is the acousto-elasticity. In this study, a new acousto-elasticity technique based on birefringence principle is proposed and tested to measure the axial stress in bolts which uses two longitudinal and shear waves instead of two horizontally polarized shear waves. From experimental results, the difference between the longitudinal and shear wave velocity is shown to be linearly related to the applied stress and be able to be used effectively to monitor the axial stress in bolts.
Repeating pulsed magnet system for axion-like particle searches and vacuum birefringence experiments
Energy Technology Data Exchange (ETDEWEB)
Yamazaki, T., E-mail: yamazaki@icepp.s.u-tokyo.ac.jp [International Center for Elementary Particle Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Inada, T.; Namba, T. [International Center for Elementary Particle Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Asai, S. [Department of Physics, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kobayashi, T. [International Center for Elementary Particle Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Matsuo, A.; Kindo, K. [The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa-shi, Chiba 277-8581 (Japan); Nojiri, H. [Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan)
2016-10-11
We have developed a repeating pulsed magnet system which generates magnetic fields of about 10 T in a direction transverse to an incident beam over a length of 0.8 m with a repetition rate of 0.2 Hz. Its repetition rate is by two orders of magnitude higher than usual pulsed magnets. It is composed of four low resistance racetrack coils and a 30 kJ transportable capacitor bank as a power supply. The system aims at axion-like particle searches with a pulsed light source and vacuum birefringence measurements. We report on the details of the system and its performances.
Zhang, Yibo; Lee, Seung Yoon Celine; Zhang, Yun; Furst, Daniel; Fitzgerald, John; Ozcan, Aydogan
2016-06-01
Gout is a form of crystal arthropathy where monosodium urate (MSU) crystals deposit and elicit inflammation in a joint. Diagnosis of gout relies on identification of MSU crystals under a compensated polarized light microscope (CPLM) in synovial fluid aspirated from the patient’s joint. The detection of MSU crystals by optical microscopy is enhanced by their birefringent properties. However, CPLM partially suffers from the high-cost and bulkiness of conventional lens-based microscopy, and its relatively small field-of-view (FOV) limits the efficiency and accuracy of gout diagnosis. Here we present a lens-free polarized microscope which adopts a novel differential and angle-mismatched polarizing optical design achieving wide-field and high-resolution holographic imaging of birefringent objects with a color contrast similar to that of a standard CPLM. The performance of this computational polarization microscope is validated by imaging MSU crystals made from a gout patient’s tophus and steroid crystals used as negative control. This lens-free polarized microscope, with its wide FOV (>20 mm2), cost-effectiveness and field-portability, can significantly improve the efficiency and accuracy of gout diagnosis, reduce costs, and can be deployed even at the point-of-care and in resource-limited clinical settings.
International Nuclear Information System (INIS)
Rodriguez, F.J.; Sanchez, C.; Villacampa, B.; Alcala, R.; Cases, R.; Millaruelo, M.; Oriol, L.
2005-01-01
Birefringence (Δn) induced in an azobenzene polymethacrylate by combination of biphotonic and thermotropic processes has subsequently been changed in sign by room temperature illumination with linearly polarized blue light. The sign of Δn can be reversed again, by simply heating up the film to 100 deg. C. This change of Δn between positive and negative values can be repeated several times. Besides, by appropriate choice of film thickness and blue light irradiation conditions the same absolute value for positive and negative Δn values can be obtained
Progress toward measuring the 6S1/2 5D3/2 magnetic-dipole transition moment in Ba+
Williams, Spencer; Jayakumar, Anupriya; Hoffman, Matthew; Blinov, Boris; Fortson, Norval
2015-05-01
We report the latest results from our effort to measure the magnetic-dipole transition moment (M1) between the 6S1 / 2 and 5D3 / 2 manifolds in Ba+. We describe a new technique for calibrating view-port birefringence and how we will use it to enhance the M1 signal. To access the transition moment we use a variation of a previously proposed technique that allows us to isolate the magnetic-dipole coupling from the much larger electric-quadrupole coupling in the transition rates between particular Zeeman sub-levels. Knowledge of M1 is crucial for a parity-nonconservation experiment in the ion where M1 will be a leading source of systematic errors. No measurement of this M1 has been made in Ba+, however, there are three calculations that predict it to be 80 ×10-5μB, 22 ×10-5μB, and 17 ×10-5μB. A precise measurement may help resolve this theoretical discrepancy which originates from their different estimations of many-body effects. Supported by NSF Grant No. 09-06494F.
International Nuclear Information System (INIS)
Khokhlov, N E; Belotelov, V I; Prokopov, A R; Shaposhnikov, A N; Berzhansky, V N; Kozhaev, M A; Andreev, S N; Zvezdin, A K; Ravishankar, Ajith P; Achanta, Venu Gopal; Bykov, D A
2015-01-01
A multilayer structure consisting of a magnetophotonic crystal with a rare-earth iron garnet microresonator layer and plasmonic grating deposited on it was fabricated and studied in order to combine functionalities of photonic and plasmonic crystals. The plasmonic pattern allows excitation of the hybrid plasmonic-waveguide modes localized in dielectric Bragg mirrors of the magnetophotonic crystal or waveguide modes inside its microresonator layer. These modes give rise to the additional resonances in the optical spectra of the structure and to the enhancement of the magneto-optical effects. The Faraday effect increases by about 50% at the microresonator modes while the transverse magneto-optical Kerr effect demonstrates pronounced peculiarities at both hybrid waveguide modes and microresonator modes and increases by several times with respect to the case of the bare magnetophotonic crystal without the metal grating. (paper)
Jia, Xiu-jie; Liu, Yan-ge; Si, Li-bin; Guo, Zhan-cheng; Fu, Sheng-gui; Kai, Gui-yun; Dong, Xiao-yi
2008-01-01
A novel multi-wavelength erbium-doped fiber laser operating in C-band is proposed and successfully demonstrated. The wavelength interval between the wavelengths is about 0.22 nm. The 3 dB bandwidth of the laser is about 0.012 nm, and the output power reaches 4.8 mW. By using a high birefringence fiber ring mirror (HiBi-FLM) and a tunable FBG, the laser realizes switchable and tunable characteristic. The mode hopping can be effectively prevented. Moreover, this laser can improve wavelength stability significantly by taking advantage of an un-pumped Er3+-doped fiber at the standing-wave section. The laser can operate in stable narrow-line-width with single-, dual-wavelength, and unstable triple-wavelength output at room temperature.
Directory of Open Access Journals (Sweden)
K. E. Zoiros
2014-07-01
Full Text Available We employ a birefringent fiber loop (BFL for enhancing the performance of a semiconductor optical amplifier (SOA which is directly modulated. By properly exploiting the BFL comb-like spectral response, we show that the SOA can be directly modulated at a data rate which is more than five times faster than that enabled by the SOA electrical bandwidth. The experimental results, which include chirp measurements, demonstrate the significant improvements achieved in the performance of the directly modulated SOA with the help of the BFL.
Measuring the Magnetic Birefringence of Vacuum: the Pvlas Experiment
Zavattini, G.; Gastaldi, U.; Pengo, R.; Ruoso, G.; Della Valle, F.; Milotti, E.
2012-06-01
We describe the principle and the status of the PVLAS experiment which is presently running at the INFN section of Ferrara, Italy, to detect the magnetic birefringence of vacuum. This is related to the QED vacuum structure and can be detected by measuring the ellipticity acquired by a linearly polarized light beam propagating through a strong magnetic field. Such an effect is predicted by the Euler-Heisenberg Lagrangian. The method is also sensitive to other hypothetical physical effects such as axion-like particles and in general to any fermion/boson millicharged particle. Here we report on the construction of our apparatus based on a high finesse (> 2·105) Fabry-Perot cavity and two 0.9 m long 2.5 T permanent dipole rotating magnets, and on the measurements performed on a scaled down test setup. With the test setup we have improved by about a factor 2 the limit on the parameter Ae describing nonlinear electrodynamic effects in vacuum: Ae < 2.9 · 10-21 T-2 @ 95% C.L.
Bjørnson; Steiner; Keddie
1997-03-01
In response to grower complaints of poor performance of Phytoseiulus persimilis, mites from 14 commercial insectaries and research colonies were examined for pathogens. Some were found to have abdominal discolorations, manifested initially as two white stripes along the dorsal sides of the body within the Malpighian tubules. Advanced signs appeared as a large, centrally located, white spot or U-shaped discoloration in the distal opisthosoma within the rectum/anal atrium. White material often accumulated and hardened within the anus and formed a rectal plug that inhibited further excretion. Most affected mites were lethargic. Adults and immatures with abdominal discoloration contained numerous densely packed, birefringent, dumbbell-shaped entities. Though occasionally observed in the colon, they occurred most frequently within the Malpighian tubules and/or rectum and anal atrium. Dumbbells measured 2-4 &mgr;m long and contained prominent concentric rings. When observed by transmission electron microscopy, the entities lacked cellular organelles. Asymptomatic mites contained few or no such entities. Dumbbell-shaped inclusions were observed in P. persimilis from all sources examined. High levels of potassium, low levels of phosphorous and sulfur, and traces of chlorine were detected by energy-dispersive X-ray analysis. Guanine and uric acid, known nitrogenous wastes of arachnids, do not contain these elements. The chemical composition and structure indicate that the dumbbells are crystals. Both asymptomatic mites and those specimens exhibiting abdominal discoloration were examined for pathogens using light and transmission electron microscopy. Microsporidia, virus-like particles, and a rickettsia (genus Wolbachia) were observed in some mites but showed no correlation with white abdominal discoloration or associated crystal formation. Neither were pathogens always detected in symptomatic mites. Although birefringent crystals may be naturally occurring excretory
Cladding defects in hollow core fibers for surface mode suppression and improved birefringence
DEFF Research Database (Denmark)
Michieletto, Mattia; Lyngso, J. K.; Lægsgaard, Jesper
2014-01-01
We demonstrate a novel polarization maintaining hollow-core photonic bandgap fiber geometry that reduces the impact of surface modes on fiber transmission. The cladding structure is modified with a row of partially collapsed holes to strip away unwanted surface modes. A theoretical investigation...... of the surface mode stripping is presented and compared to the measured performance of four 7-cells core fibers that were drawn with different collapse ratio of the defects. The varying pressure along the defect row in the cladding during drawing introduces an ellipticity of the core. This, combined...... with the presence of antiresonant features on the core wall, makes the fibers birefringent, with excellent polarization maintaining properties. (C) 2014 Optical Society of America...
Irsch, Kristina; Gramatikov, Boris I.; Wu, Yi-Kai; Guyton, David L.
2014-06-01
Amblyopia ("lazy eye") is a major public health problem, caused by misalignment of the eyes (strabismus) or defocus. If detected early in childhood, there is an excellent response to therapy, yet most children are detected too late to be treated effectively. Commercially available vision screening devices that test for amblyopia's primary causes can detect strabismus only indirectly and inaccurately via assessment of the positions of external light reflections from the cornea, but they cannot detect the anatomical feature of the eyes where fixation actually occurs (the fovea). Our laboratory has been developing technology to detect true foveal fixation, by exploiting the birefringence of the uniquely arranged Henle fibers delineating the fovea using retinal birefringence scanning (RBS), and we recently described a polarization-modulated approach to RBS that enables entirely direct and reliable detection of true foveal fixation, with greatly enhanced signal-to-noise ratio and essentially independent of corneal birefringence (a confounding variable with all polarization-sensitive ophthalmic technology). Here, we describe the design and operation of a new pediatric vision screener that employs polarization-modulated, RBS-based strabismus detection and bull's eye focus detection with an improved target system, and demonstrate the feasibility of this new approach.
Irsch, Kristina; Gramatikov, Boris I; Wu, Yi-Kai; Guyton, David L
2014-06-01
Amblyopia ("lazy eye") is a major public health problem, caused by misalignment of the eyes (strabismus) or defocus. If detected early in childhood, there is an excellent response to therapy, yet most children are detected too late to be treated effectively. Commercially available vision screening devices that test for amblyopia's primary causes can detect strabismus only indirectly and inaccurately via assessment of the positions of external light reflections from the cornea, but they cannot detect the anatomical feature of the eyes where fixation actually occurs (the fovea). Our laboratory has been developing technology to detect true foveal fixation, by exploiting the birefringence of the uniquely arranged Henle fibers delineating the fovea using retinal birefringence scanning (RBS), and we recently described a polarization-modulated approach to RBS that enables entirely direct and reliable detection of true foveal fixation, with greatly enhanced signal-to-noise ratio and essentially independent of corneal birefringence (a confounding variable with all polarization-sensitive ophthalmic technology). Here, we describe the design and operation of a new pediatric vision screener that employs polarization-modulated, RBS-based strabismus detection and bull's eye focus detection with an improved target system, and demonstrate the feasibility of this new approach.
Phan, Quoc-Hung; Lo, Yu-Lung
2017-04-01
A surface plasmon resonance (SPR)-enhanced method is proposed for measuring the circular dichroism (CD), circular birefringence (CB), and degree of polarization (DOP) of turbid media using a Stokes–Mueller matrix polarimetry technique. The validity of the analytical model is confirmed by means of numerical simulations. The simulation results show that the proposed detection method enables the CD and CB properties to be measured with a resolution of 10 ? 4 refractive index unit (RIU) and 10 ? 5 ?? RIU , respectively, for refractive indices in the range of 1.3 to 1.4. The practical feasibility of the proposed method is demonstrated by detecting the CB/CD/DOP properties of glucose–chlorophyllin compound samples containing polystyrene microspheres. It is shown that the extracted CB value decreases linearly with the glucose concentration, while the extracted CD value increases linearly with the chlorophyllin concentration. However, the DOP is insensitive to both the glucose concentration and the chlorophyllin concentration. Consequently, the potential of the proposed SPR-enhanced Stokes–Mueller matrix polarimetry method for high-resolution CB/CD/DOP detection is confirmed. Notably, in contrast to conventional SPR techniques designed to detect relative refractive index changes, the SPR technique proposed in the present study allows absolute measurements of the optical properties (CB/CD/DOP) to be obtained.
Optical properties study of nano-composite filled D shape photonic crystal fibre
Udaiyakumar, R.; Mohamed Junaid, K. A.; Janani, T.; Maheswar, R.; Yupapin, P.; Amiri, I. S.
2018-06-01
With the nano-composite materials gaining momentum in the optical field, a new nano-composite filled D shape Photonic Crystal Fiber (PCF) is designed and the various optical properties are investigated with help of Finite Element Method. In the proposed structure the D-shape PCF is made up of silica with embedded silver nanoparticles and air holes are distributed along the fibre. The designed fibre shows various optical properties such as dispersion, birefringence, beat length and loss with respect to wavelength and compared with different filling factor like 0.1, 0.3 and 0.5. From our estimation and comparative analysis, it has been proved that the fibre loss has been decreased with increasing filling factor. Further this also showed flat dispersion at maximum filling factor.
Generation and dynamics of quadratic birefringent spatial gap solitons
International Nuclear Information System (INIS)
Anghel-Vasilescu, P.; Dorignac, J.; Geniet, F.; Leon, J.; Taki, A.
2011-01-01
A method is proposed to generate and study the dynamics of spatial light solitons in a birefringent medium with quadratic nonlinearity. Although no analytical expression for propagating solitons has been obtained, our numerical simulations show the existence of stable localized spatial solitons in the frequency forbidden band gap of the medium. The dynamics of these objects is quite rich and manifests for instance elastic reflections, or inelastic collisions where two solitons merge and propagate as a single solitary wave. We derive the dynamics of the slowly varying envelopes of the three fields (second harmonic pump and two-component signal) and study this new system theoretically. We show that it does present a threshold for nonlinear supratransmission that can be calculated from a series expansion approach with a very high accuracy. Specific physical implications of our theoretical predictions are illustrated on LiGaTe 2 (LGT) crystals. Once irradiated by a cw laser beam of 10 μm wavelength, at an incidence beyond the extinction angle, such crystals will transmit light, in the form of spatial solitons generated in the nonlinear regime above the nonlinear supratransmission threshold.
Dubolazov, O. V.; Ushenko, V. O.; Trifoniuk, L.; Ushenko, Yu. O.; Zhytaryuk, V. G.; Prydiy, O. G.; Grytsyuk, M.; Kushnerik, L.; Meglinskiy, I.
2017-09-01
A new technique of Mueller-matrix mapping of polycrystalline structure of histological sections of biological tissues is suggested. The algorithms of reconstruction of distribution of parameters of linear and circular birefringence of prostate histological sections are found. The interconnections between such distributions and parameters of linear and circular birefringence of prostate tissue histological sections are defined. The comparative investigations of coordinate distributions of phase anisotropy parameters formed by fibrillar networks of prostate tissues of different pathological states (adenoma and carcinoma) are performed. The values and ranges of change of the statistical (moments of the 1st - 4th order) parameters of coordinate distributions of the value of linear and circular birefringence are defined. The objective criteria of cause of Benign and malignant conditions differentiation are determined.
Optical Search for QED vacuum magnetic birefringence, Axions and photon Regeneration
Pugnat, P; Hryczuk, A; Finger, M; Finger, M; Kral, M
2007-01-01
Since its prediction in 1936 by Euler, Heisenberg and Weisskopf in the earlier development of the Quantum Electrodynamic (QED) theory, the Vacuum Magnetic Birefringence (VMB) is still a challenge for optical metrology techniques. According to QED, the vacuum behaves as an optically active medium in the presence of an external magnetic field. It can be experimentally probed with a linearly polarized laser beam. After propagating through the vacuum submitted to a transverse magnetic field, the polarization of the laser beam will change to elliptical and the parameters of the polarization are directly related to fundamental constants such as the fine structure constant and the electron Compton wavelength. Contributions to the VMB could also arise from the existence of light scalar or pseudo-scalar particles like axions that couple to two photons and this would manifest itself as a sizeable deviation from the initial QED prediction. On one side, the interest in axion search, providing an answer to the strong-CP p...
Fabrication of birefringent nanocylinders for single-molecule force and torque measurement
Li, Ping-Chun; Chang, Jen-Chien; La Porta, Arthur; Yu, Edward T.
2014-06-01
Optically anisotropic subwavelength scale dielectric particles have been shown to enable studies of the mechanical properties of bio-molecules via optical trapping and manipulation. However, techniques emphasized to date for fabrication of such particles generally suffer from limited uniformity and control over particle dimensions, or low throughput and high cost. Here, an approach for rapid, low-cost, fabrication of large quantities of birefringent quartz nanocylinders with dimensions optimized for optical torque wrench experiments is described. For a typical process, 108 or more quartz cylinders with diameters of 500 nm and heights of 800 nm, with uniformity of ±5% in each dimension, can be fabricated over ˜10 cm2 areas, for binding to a single bio-molecule, and harvested for use in optical trapping experiments. Use of these structures to measure extensional and torsional dynamics of single DNA molecules is demonstrated with measured forces and torques shown to be in very good agreement with previously reported results.
Fabrication of birefringent nanocylinders for single-molecule force and torque measurement
International Nuclear Information System (INIS)
Li, Ping-Chun; T Yu, Edward; Chang, Jen-Chien; La Porta, Arthur
2014-01-01
Optically anisotropic subwavelength scale dielectric particles have been shown to enable studies of the mechanical properties of bio-molecules via optical trapping and manipulation. However, techniques emphasized to date for fabrication of such particles generally suffer from limited uniformity and control over particle dimensions, or low throughput and high cost. Here, an approach for rapid, low-cost, fabrication of large quantities of birefringent quartz nanocylinders with dimensions optimized for optical torque wrench experiments is described. For a typical process, 10 8 or more quartz cylinders with diameters of 500 nm and heights of 800 nm, with uniformity of ±5% in each dimension, can be fabricated over ∼10 cm 2 areas, for binding to a single bio-molecule, and harvested for use in optical trapping experiments. Use of these structures to measure extensional and torsional dynamics of single DNA molecules is demonstrated with measured forces and torques shown to be in very good agreement with previously reported results. (papers)
Interrogation and mitigation of polarization effects for standard and birefringent FBGs
Ibrahim, Selwan K.; Van Roosbroeck, Jan; O'Dowd, John A.; Van Hoe, Bram; Lindner, Eric; Vlekken, Johan; Farnan, Martin; Karabacak, Devrez M.; Singer, Johannes M.
2016-05-01
Optical sensors based on Fiber Bragg Gratings (FBGs) are used in several applications and industries. Several inscription techniques and type of fibers can be used. However, depending on the writing process, type of fiber used and the packaging of the sensor a Polarization Dependent Frequency Shift (PDFS) can often be observed with polarized tunable laser based optical interrogators. Here we study the PDFS of the FBG peak for the different FBG types. A PDFS of 20pm was observed across the FBGs. To mitigate and reduce this effect we propose a polarization mitigation technique which relies on a synchronous polarization switch to reduce the effect typically by a factor greater than 4. In other scenarios the sensor itself is designed to be birefringent (Bi-FBG) to allow pressure and/or simultaneous temperature and strain measurements. Using the same polarization switch we demonstrate how we can interrogate the Bi-FBGs with high accuracy to enable high performance of such sensors to be achievable.
Analysis of photoinduced birefringence in azo-dye doped films by a fast imaging technique
International Nuclear Information System (INIS)
Marino, Iari-Gabriel; Lottici, Pier Paolo
2010-01-01
In photo-birefringent films, the relationship ρ(I) between optical retardation ρ and pump irradiance I may be obtained with imaging techniques applied within a pump-probe setup. However, measurement of ρ(I) are reported only at long irradiation times and low time-resolution. In this paper we describe a polariscopic imaging technique with higher sensitivity (by a factor of ∼ 30), where the probe beam is focused on the entrance pupil of the camera ('Maxwellian view'). The technique is applied to an azo-dye doped polymeric film, obtaining the continuous ρ(I) curve after irradiation times from 10 ms to 240 ms. Exponential functions are fitted against the experimental data both as a function of time and irradiance.
Sun, Xuehuan; Wu, Yongxiao; Chen, Sanbin; Li, Jianlang
2018-05-01
In this paper, we demonstrated a passive Q-switched ytterbium-doped fiber laser with radially polarized beam emission by using a c-cut YVO4 birefringent crystal as the intracavity polarization discriminator, and a Cr4+:YAG crystal as the saturable absorber and output coupler. The maximum averaged laser power reached 3.89 W with a high slope efficiency of 66.5%. The laser pulse had a peak power of 161 W, 160 ns duration, and 151 kHz repetition rate at the absorbed pump power of 6.48 W. Such a radially polarized pulse would facilitate numerous applications.
Darrow, Chris; Seger, Tino
2003-09-30
A transparent flow channel fluidly communicates a fluid source and a collection reservoir. An interrogating light beam passes through a first polarizer having a first plane of polarization. The flow channel is orthogonal to the light beam. The light beam passes through a fluid sample as it flows through the flow channel, and is then filtered through a second polarizer having a second plane of polarization rotated 90.degree. from the first plane of polarization. An electronic photo-detector is aligned with the light beam, and signals the presence of birefringent microcrystals in the fluid sample by generating voltage pulses. A disposable containment fixture includes the flow channel and the collection reservoir. The fixture is adapted for removable insertion into an interrogation cradle that includes optical and data processing components. The cradle rigidly positions the centerline of the flow channel orthogonal to the light beam.
Unsal, E.; Drum, J.; Yucel, O.; Nugay, I. I.; Yalcin, B.; Cakmak, M.
2012-02-01
This paper describes the design and performance of a new instrument to track temporal changes in physical parameters during the drying behavior of solutions, as well as curing of monomers. This real-time instrument follows in-plane and out-of-plane birefringence, weight, thickness, and surface temperature during the course of solidification of coatings and films through solvent evaporation and thermal or photocuring in a controlled atmosphere. It is specifically designed to simulate behavior of polymer solutions inside an industrial size, continuous roll-to-roll solution casting line and other coating operations where resins are subjected to ultraviolet (UV) curing from monomer precursors. Controlled processing parameters include air speed, temperature, initial cast thickness, and solute concentration, while measured parameters are thickness, weight, film temperature, in-plane and out-of-plane birefringence. In this paper, we illustrate the utility of this instrument with solution cast and dried poly (amide-imide)/DMAc (Dimethylacetamide) solution, water based black paint, and organo-modified clay/NMP (N-Methylpyrrolidone) solution. In addition, the physical changes that take place during UV photo polymerization of a monomer are tracked. This instrument is designed to be generic and it can be used for tracking any drying/swelling/solidification systems including paper, foodstuffs such as; grains, milk as well as pharmaceutical thin paste and slurries.
He, Haijun; Shao, Liyang; Qian, Heng; Zhang, Xinpu; Liang, Jiawei; Luo, Bin; Pan, Wei; Yan, Lianshan
2017-03-20
A novel demodulation method for Sagnac loop interferometer based sensor has been proposed and demonstrated, by unwrapping the phase changes with birefringence interrogation. A temperature sensor based on Sagnac loop interferometer has been used to verify the feasibility of the proposed method. Several tests with 40 °C temperature range have been accomplished with a great linearity of 0.9996 in full range. The proposed scheme is universal for all Sagnac loop interferometer based sensors and it has unlimited linear measurable range which overwhelming the conventional demodulation method with peak/dip tracing. Furthermore, the influence of the wavelength sampling interval and wavelength span on the demodulation error has been discussed in this work. The proposed interrogation method has a great significance for Sagnac loop interferometer sensor and it might greatly enhance the availability of this type of sensors in practical application.
Rao, Harsha L; Yadav, Ravi K; Begum, Viquar U; Addepalli, Uday K; Senthil, Sirisha; Choudhari, Nikhil S; Garudadri, Chandra S
2015-03-01
To evaluate the effect of typical scan score (TSS), when within the acceptable limits, on the diagnostic performance of retinal nerve fibre layer (RNFL) parameters with the enhanced corneal compensation (ECC) protocol of scanning laser polarimetry (SLP) in glaucoma. In a cross-sectional study, 203 eyes of 160 glaucoma patients and 140 eyes of 104 control subjects underwent RNFL imaging with the ECC protocol of SLP. TSS was used to quantify atypical birefringence pattern (ABP) images. Influence of TSS on the diagnostic ability of SLP parameters was evaluated by receiver operating characteristic (ROC) regression models after adjusting for the effect of disease severity [based on mean deviation (MD)] on standard automated perimetry). Diagnostic abilities of all RNFL parameters of SLP increased when the TSS values were higher. This effect was statistically significant for TSNIT (coefficient: 0.08, p<0.001) and inferior average parameters (coefficient: 0.06, p=0.002) but not for nerve fibre indicator (NFI, coefficient: 0.03, p=0.21). In early glaucoma (MD of -5 dB), predicted area under ROC curve (AUC) for TSNIT average parameter improved from 0.642 at a TSS of 90 to 0.845 at a TSS of 100. In advanced glaucoma (MD of -15 dB), AUC for TSNIT average improved from 0.832 at a TSS of 90 to 0.947 at 100. Diagnostic performances of TSNIT and inferior average RNFL parameters with ECC protocol of SLP were significantly influenced by TSS even when the TSS values were within the acceptable limits. Diagnostic ability of NFI was unaffected by TSS values. © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
Energy Technology Data Exchange (ETDEWEB)
Popovic, Marta; Zaja, Roko [Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Rudjer Boskovic Institute, Bijenicka 54, 10 000 Zagreb (Croatia); Fent, Karl [University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz (Switzerland); Swiss Federal Institute of Technology (ETH Zürich), Department of Environmental System Sciences, Institute of Biogeochemistry and Pollution Dynamics, CH-8092 Zürich (Switzerland); Smital, Tvrtko, E-mail: smital@irb.hr [Laboratory for Molecular Ecotoxicology, Division for Marine and Environmental Research, Rudjer Boskovic Institute, Bijenicka 54, 10 000 Zagreb (Croatia)
2014-10-01
Polyspecific transporters from the organic anion transporting polypeptide (OATP/Oatp) superfamily mediate the uptake of a wide range of compounds. In zebrafish, Oatp1d1 transports conjugated steroid hormones and cortisol. It is predominantly expressed in the liver, brain and testes. In this study we have characterized the transport of xenobiotics by the zebrafish Oatp1d1 transporter. We developed a novel assay for assessing Oatp1d1 interactors using the fluorescent probe Lucifer yellow and transient transfection in HEK293 cells. Our data showed that numerous environmental contaminants interact with zebrafish Oatp1d1. Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17α-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor. Importantly, many environmental chemicals acted as strong inhibitors of Oatp1d1. A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17β-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. In this study we identified Oatp1d1 as a first Solute Carrier (SLC) transporter involved in the transport of a wide range of xenobiotics in fish. Considering that Oatps in zebrafish have not been characterized before, our work on zebrafish Oatp1d1 offers important new insights on the understanding of uptake processes of environmental contaminants, and contributes to the better characterization of zebrafish as a model species. - Highlights: • We optimized a novel assay for determination of Oatp1d1 interactors • Oatp1d1 is the first SLC characterized fish xenobiotic transporter • PFOS, nonylphenol, diclofenac, EE2, caffeine are high affinity Oatp1d1substrates • PFOA, chlorpyrifos
International Nuclear Information System (INIS)
Popovic, Marta; Zaja, Roko; Fent, Karl; Smital, Tvrtko
2014-01-01
Polyspecific transporters from the organic anion transporting polypeptide (OATP/Oatp) superfamily mediate the uptake of a wide range of compounds. In zebrafish, Oatp1d1 transports conjugated steroid hormones and cortisol. It is predominantly expressed in the liver, brain and testes. In this study we have characterized the transport of xenobiotics by the zebrafish Oatp1d1 transporter. We developed a novel assay for assessing Oatp1d1 interactors using the fluorescent probe Lucifer yellow and transient transfection in HEK293 cells. Our data showed that numerous environmental contaminants interact with zebrafish Oatp1d1. Oatp1d1 mediated the transport of diclofenac with very high affinity, followed by high affinity towards perfluorooctanesulfonic acid (PFOS), nonylphenol, gemfibrozil and 17α-ethinylestradiol; moderate affinity towards carbaryl, diazinon and caffeine; and low affinity towards metolachlor. Importantly, many environmental chemicals acted as strong inhibitors of Oatp1d1. A strong inhibition of Oatp1d1 transport activity was found by perfluorooctanoic acid (PFOA), chlorpyrifos-methyl, estrone (E1) and 17β-estradiol (E2), followed by moderate to low inhibition by diethyl phthalate, bisphenol A, 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4 tetrahydronapthalene and clofibrate. In this study we identified Oatp1d1 as a first Solute Carrier (SLC) transporter involved in the transport of a wide range of xenobiotics in fish. Considering that Oatps in zebrafish have not been characterized before, our work on zebrafish Oatp1d1 offers important new insights on the understanding of uptake processes of environmental contaminants, and contributes to the better characterization of zebrafish as a model species. - Highlights: • We optimized a novel assay for determination of Oatp1d1 interactors • Oatp1d1 is the first SLC characterized fish xenobiotic transporter • PFOS, nonylphenol, diclofenac, EE2, caffeine are high affinity Oatp1d1substrates • PFOA, chlorpyrifos
1,5-Anhydro-D-fructose from D-fructose
DEFF Research Database (Denmark)
Dekany, Gyula; Lundt, Inge; Niedermaier, Fabian
2007-01-01
1,5-Anhydro-D-fructose was efficiently prepared from D-fructose via regiospecific 1,5-anhydro ring formation of 2,3-O-isopropylidene-1-O-methyl(tolyl)sulfonyl-D-fructopyranose and subsequent deprotection.......1,5-Anhydro-D-fructose was efficiently prepared from D-fructose via regiospecific 1,5-anhydro ring formation of 2,3-O-isopropylidene-1-O-methyl(tolyl)sulfonyl-D-fructopyranose and subsequent deprotection....
Energy Technology Data Exchange (ETDEWEB)
Razamat, Shlomo S. [Physics Department, Technion,Haifa, 32000 (Israel); Vafa, Cumrun [Jefferson Physical Laboratory, Harvard University,Cambridge, MA 02138 (United States); Zafrir, Gabi [Physics Department, Technion,Haifa, 32000 (Israel); Kavli IPMU (WPI), UTIAS, the University of Tokyo,Kashiwa, Chiba 277-8583 (Japan)
2017-04-11
We study the geometry of 4d N=1 SCFT’s arising from compactification of 6d (1,0) SCFT’s on a Riemann surface. We show that the conformal manifold of the resulting theory is characterized, in addition to moduli of complex structure of the Riemann surface, by the choice of a connection for a vector bundle on the surface arising from flavor symmetries in 6d. We exemplify this by considering the case of 4d N=1 SCFT’s arising from M5 branes probing ℤ{sub k} singularity compactified on a Riemann surface. In particular, we study in detail the four dimensional theories arising in the case of two M5 branes on ℤ{sub 2} singularity. We compute the conformal anomalies and indices of such theories in 4d and find that they are consistent with expectations based on anomaly and the moduli structure derived from the 6 dimensional perspective.
Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose.
Dekany, Gyula; Lundt, Inge; Steiner, Andreas J; Stütz, Arnold E
2006-07-24
1,4-Anhydro-D-fructose and 1,4-anhydro-D-tagatose were prepared from 1,2-O-isopropylidene-D-glucofuranose via the common intermediate 3,5,6-tri-O-benzyl-D-glucitol. The title compounds may be interesting anti-oxidants and feature activities akin to their natural pyranoid counterpart, 1,5-anhydro-D-fructose.
Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose
DEFF Research Database (Denmark)
Dekany, Gyula; Lundt, Inge; Steiner, Andreas J.
2006-01-01
1,4-Anhydro-D-fructose and 1,4-anhydro-D-tagatose were prepared from 1,2-O-isopropylidene-D-glucofuranose via the common intermediate 3,5,6-tri-O-benzyl-D-glucitol. The title compounds may be interesting anti-oxidants and feature activities akin to their natural pyranoid counterpart, 1,5-anhydro-D-fructose....
International Nuclear Information System (INIS)
Yamato, H.; Matsumoto, T.; Fukumoto, S.; Ikeda, K.; Ishizuka, S.; Ogata, E.
1989-01-01
Previous studies revealed that administration of 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] to calcium (Ca)-deficient rats causes a dose-dependent reduction in markedly elevated serum 1,25-(OH)2D3 level. Although the results suggested that the metabolism of 1,25-(OH)2D3 was accelerated by 24,25-(OH)2D3, those experiments could not define whether the enhanced metabolism of 1,25-(OH)2D3 played a role in the reduction in the serum 1,25-(OH)2D3 level. In the present study, in order to address this issue more specifically, serum 1,25-(OH)2D3 was maintained solely by exogenous administration through miniosmotic pumps of 1,25-(OH)2D3 into vitamin D-deficient rats. Thus, by measuring the serum 1,25-(OH)2D3 concentration, the effect of 24,25-(OH)2D3 on the MCR of 1,25-(OH)2D3 could be examined. Administration of 24,25-(OH)2D3 caused a dose-dependent enhancement in the MCR of 1,25-(OH)2D3, and 1 microgram/100 g rat.day 24,25-(OH)2D3, which elevated serum 24,25-(OH)2D3 to 8.6 +/- 1.3 ng/ml, significantly increased MCR and suppressed serum levels of 1,25-(OH)2D3. The effect of 24,25-(OH)2D3 on 1,25-(OH)2D3 metabolism developed with a rapid time course, and the recovery of iv injected [1 beta-3H]1,25-(OH)2D3 in blood was significantly reduced within 1 h. In addition, there was an increase in radioactivity in the water-soluble fraction of serum as well as in urine, suggesting that 1,25-(OH)2D3 is rapidly degraded to a water-soluble metabolite(s). Furthermore, the reduction in serum 1,25-(OH)2D3 was associated with a reduction in both serum and urinary Ca levels. Because the conversion of [3H]24,25-(OH)2D3 to [3H]1,24,25-(OH)2D3 or other metabolites was minimal in these rats, 24,25-(OH)2D3 appears to act without being converted into other metabolites. These results demonstrate that 24,25-(OH)2D3 rapidly stimulates the metabolism of 1,25-(OH)2D3 and reduces its serum level
International Nuclear Information System (INIS)
Purdy, Kirstin R.; Dogic, Zvonimir; Fraden, Seth; Ruehm, Adrian; Lurio, Lawrence; Mochrie, Simon G. J.
2003-01-01
The orientational distribution function of the nematic phase of suspensions of the semiflexible rodlike virus fd is measured by x-ray diffraction as a function of concentration and ionic strength. X-ray diffraction from a single-domain nematic phase of fd is influenced by interparticle correlations at low angle, while only intraparticle scatter contributes at high angle. Consequently, the angular distribution of the scattered intensity arises from only the single-particle orientational distribution function at high angle but it also includes spatial and orientational correlations at low angle. Experimental measurements of the orientational distribution function from both the interparticle (structure factor) and intraparticle (form factor) scattering were made to test whether the correlations present in interparticle scatter influence the measurement of the single-particle orientational distribution function. It was found that the two types of scatter yield consistent values for the nematic order parameter. It was also found that x-ray diffraction is insensitive to the orientational distribution function's precise form, and the measured angular intensity distribution is described equally well by both Onsager's trial function and a Gaussian. At high ionic strength, the order parameter S of the nematic phase coexisting with the isotropic phase approaches theoretical predictions for long semiflexible rods S=0.55, but deviations from theory increase with decreasing ionic strength. The concentration dependence of the nematic order parameter also better agrees with theoretical predictions at high ionic strength indicating that electrostatic interactions have a measurable effect on the nematic order parameter. The x-ray order parameters are shown to be proportional to the measured birefringence, and the saturation birefringence of fd is determined enabling a simple, inexpensive way to measure the order parameter. Additionally, the spatial ordering of nematic fd was probed
Asraf, Sagie; Sintov, Yoav; Zalevsky, Zeev
2017-08-07
We propose a novel configuration for an improved and compact all fiber Faraday rotator based on phase matching between the Faraday rotation and bend-induced birefringence. The device utilizes a coiled fiber within two electro-magnetic toroids, such that the fiber length required for getting the beat length is quite long and several rounds of fiber are needed. Analysis of the capabilities of the proposed device and its sensitivity to different parameters is presented. Faraday rotation of 13° was experimentally measured in six meters of single mode silica fiber, with a magnetic field of about 0.06T at a wavelength of 1064nm. We show that phase matching between the two phenomena significantly improves the polarization rotation by a factor of 4-10. In addition, we demonstrate the ability to achieve higher rotation by using Fabry Perot resonator in low terbium doped glass.
Vidal, Marcos; Ramana, Chilakamarti V.; Dusso, Adriana S.
2002-01-01
The cytokine gamma interferon (IFN-γ) and the calcitropic steroid hormone 1,25-dihydroxyvitamin D (1,25D) are activators of macrophage immune function. In sarcoidosis, tuberculosis, and several granulomatoses, IFN-γ induces 1,25D synthesis by macrophages and inhibits 1,25D induction of 24-hydroxylase, a key enzyme in 1,25D inactivation, causing high levels of 1,25D in serum and hypercalcemia. This study delineates IFN-γ-1,25D cross talk in human monocytes-macrophages. Nuclear accumulation of Stat1 and vitamin D receptor (VDR) by IFN-γ and 1,25D promotes protein-protein interactions between Stat1 and the DNA binding domain of the VDR. This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene. In contrast, 1,25D enhances IFN-γ action. Stat1-VDR interactions, by preventing Stat1 deactivation by tyrosine dephosphorylation, cooperate with IFN-γ/Stat1-induced transcription. This novel 1,25D-IFN-γ cross talk explains the pathogenesis of abnormal 1,25D homeostasis in granulomatous processes and provides new insights into 1,25D immunomodulatory properties. PMID:11909970
D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860): candidates for 1D charmed-strange mesons
Energy Technology Data Exchange (ETDEWEB)
Song, Qin-Tao [Chinese Academy of Sciences, Nuclear Theory Group, Institute of Modern Physics, Lanzhou (China); Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); University of Chinese Academy of Sciences, Beijing (China); Chen, Dian-Yong [Chinese Academy of Sciences, Nuclear Theory Group, Institute of Modern Physics, Lanzhou (China); Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Liu, Xiang [Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Lanzhou University, School of Physical Science and Technology, Lanzhou (China); Matsuki, Takayuki [Tokyo Kasei University, Tokyo (Japan); RIKEN, Theoretical Research Division, Nishina Center, Saitama (Japan)
2015-01-01
Newly observed two charmed-strange resonances, D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860), are investigated by calculating their Okubo-Zweig-Iizuka-allowed strong decays, which shows that they are suitable candidates for the 1{sup 3}D{sub 1} and 1{sup 3}D{sub 3} states in the charmed-strange meson family. Our study also predicts other main decay modes of D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860), which can be accessible at the future experiment. In addition, the decay behaviors of the spin partners of D{sub s1}{sup *}(2860) and D{sub s3}{sup *}(2860), i.e., 1D(2{sup -}) and 1D'(2{sup -}), are predicted in this work, which are still missing at present. The experimental search for the missing 1D(2{sup -}) and 1D'(2{sup -}) charmed-strange mesons is an intriguing and challenging task for further experiments. (orig.)
Eternal 5D optical data storage in glass (Conference Presentation)
Kazansky, Peter G.; Cerkauskaite, Ausra; Drevinskas, Rokas; Zhang, Jingyu
2016-09-01
A decade ago it has been discovered that during femtosecond laser writing self-organized subwavelength structures with record small features of 20 nm, could be created in the volume of silica glass. On the macroscopic scale the self-assembled nanostructure behaves as a uniaxial optical crystal with negative birefringence. The optical anisotropy, which results from the alignment of nano-platelets, referred to as form birefringence, is of the same order of magnitude as positive birefringence in crystalline quartz. The two independent parameters describing birefringence, the slow axis orientation (4th dimension) and the strength of retardance (5th dimension), are explored for the optical encoding of information in addition to three spatial coordinates. The slow axis orientation and the retardance are independently manipulated by the polarization and intensity of the femtosecond laser beam. The data optically encoded into five dimensions is successfully retrieved by quantitative birefringence measurements. The storage allows unprecedented parameters including hundreds of terabytes per disc data capacity and thermal stability up to 1000°. Even at elevated temperatures of 160oC, the extrapolated decay time of nanogratings is comparable with the age of the Universe - 13.8 billion years. The recording of the digital documents, which will survive the human race, including the eternal copies of Universal Declaration of Human Rights, Newton's Opticks, Kings James Bible and Magna Carta, is a vital step towards an eternal archive. Additionally, a number of projects (such as Time Capsule to Mars, MoonMail, and the Google Lunar XPRIZE) could benefit from the technique's extreme durability, which fulfills a crucial requirement for storage on the Moon or Mars.
Vidal, Marcos; Ramana, Chilakamarti V.; Dusso, Adriana S.
2002-01-01
The cytokine gamma interferon (IFN-γ) and the calcitropic steroid hormone 1,25-dihydroxyvitamin D (1,25D) are activators of macrophage immune function. In sarcoidosis, tuberculosis, and several granulomatoses, IFN-γ induces 1,25D synthesis by macrophages and inhibits 1,25D induction of 24-hydroxylase, a key enzyme in 1,25D inactivation, causing high levels of 1,25D in serum and hypercalcemia. This study delineates IFN-γ-1,25D cross talk in human monocytes-macrophages. Nuclear accumulation of ...
DEFF Research Database (Denmark)
Pedersen, U B; Norby, B; Jensen, Anders A.
1994-01-01
Human dopamine D1a and D1b receptors were stably expressed in Baby Hamster Kidney (BHK) or Chinese Hamster Ovary (CHO) cells. [3H]SCH23390 saturation experiments indicated the presence of only a single binding site in the D1a expressing cell line with a Kd of 0.5 nM. In D1b expressing cell lines...
Freimuth, Paul I.
2010-04-06
The invention provides recombinant human CAR (coxsackievirus and adenovirus receptor) polypeptides which bind adenovirus. Specifically, polypeptides corresponding to adenovirus binding domain D1 and the entire extracellular domain of human CAR protein comprising D1 and D2 are provided. In another aspect, the invention provides nucleic acid sequences encoding these domains and expression vectors for producing the domains and bacterial cells containing such vectors. The invention also includes an isolated fusion protein comprised of the D1 polypeptide fused to a polypeptide which facilitates folding of D1 when expressed in bacteria. The functional D1 domain finds application in a therapeutic method for treating a patient infected with a CAR D1-binding virus, and also in a method for identifying an antiviral compound which interferes with viral attachment. The invention also provides a method for specifically targeting a cell for infection by a virus which binds to D1.
Directory of Open Access Journals (Sweden)
S. V. Arkhipov,
2016-05-01
Full Text Available The paper deals withpoint-by-point inscriptionof fiber Bragg gratings by the 800 nm Ti:Sa femtosecond laser pulses into a unique birefringent fiber with elliptical stress cladding of home manufacture. The proposed inscriptionmethod has advantages over the conventional phase mask method. The possibility to create complex grating structures and relatively high transparency of acrylate coating to the Ti:Sa femtosecond laser radiation of 800 nm gives the possibility for inscriptionof phase shifting gratings, chirped grating and superstructures without stripping the fiber. Also, this method makes it possible to inscribethese diffractive structures with and without co-doping of GeO2 in the fiber core. Achieved reflectance was 10%. The microscopic image of the diffractive structure in the fiber core is presented. The grating of 1.07 µm is realized by pulling the fiber with constant speed while the laser pulses are applied with a repetition frequency of 1 kHz. The results are usable in the sphere of creation of different fiber optic sensitive elements based on Bragg gratings.
International Nuclear Information System (INIS)
Mao Wei; Zhang Shulian
2007-01-01
Optical feedback effects are studied in a birefringence-Zeeman dual frequency laser at high optical feedback levels. The intensity modulation features of the two orthogonally polarized lights are investigated in both isotropic optical feedback (IOF) and polarized optical feedback (POF). In IOF, the intensities of both beams are modulated simultaneously, and four zones, i.e., the e-light zone, the o-light and e-light zone, the o-light zone, and the no-light zone, are formed in a period corresponding to a half laser wavelength displacement of the feedback mirror. In POF, the two orthogonally polarized lights will oscillate alternately. Strong mode competition can be observed, and it affects the phase difference between the two beams greatly. The theoretical analysis is presented, which is in good agreement with the experimental results. The potential use of the experimental results is also discussed
Mahmood, Tanvir
Considering the network size, bit rate, spectral and channel capacity limitations, different modulation formats may be selectively used in future optical networks. Although the traditional metropolitan area networks (MANs) still uses the non-return-to-zero on-off keying (NRZ-OOK) modulation format due to its technical simplicity and therefore low cost, QPSK format is more advantageous in spectrally efficient long-haul fiber optic transmission systems because of its constant power envelope, and robustness to various transmission impairments. Consequently, an important problem may arise, in particular how to route the OOK-data streams from MANs to long-haul backbone networks when the state of polarization (SOP) of the remotely generated OOK is unpredictable. Hence, the focus of this dissertation was to investigate a polarization insensitive (PI) all-optical nonlinear optical signal processing (NOSP) method that can be implemented at the network cross-connect (X-connect) to transfer data from a remotely and a locally generated OOK data simultaneously to more effectual QPSK format for long-haul transmission. By utilizing cross-phase modulation (XPM) and inherent birefringence of the device, the work demonstrated, for the first time, PI all-optical data transfer utilizing dual pump-phase transmultiplexing (DPTM) from 2 x 10-GBd OOKs to 10-GBd RZ-QPSK in a passive nonlinear birefringent photonic crystal fiber (PCF). Polarization insensitivity was achieved by scrambling the SOP of the remotely generated OOK pump and launching the locally generated OOK pump and the probe off-axis. To mitigate polarization induced power fluctuations and detrimental effects due to nearby partially degenerate and non-degenerate four wave mixings, an optimum pump-probe detuning was also utilized. The PI DPTM RZ-QPSK demonstrated a pre-amplified receiver sensitivity penalty < 5.5 dB at 10--9 bit-error-rate (BER), relative to relative to the FPGA-precoded RZ-DQPSK baseline in ASE
Quach, Holly P; Dzekic, Tamara; Bukuroshi, Paola; Pang, K Sandy
2018-04-01
Vitamin D 3 and the synthetic vitamin D analogs, 1α-hydroxyvitamin D 3 [1α(OH)D 3 ], 1α-hydroxyvitamin D 2 [1α(OH)D 2 ] and 25-hydroxyvitamin D 3 [25(OH)D 3 ] were appraised for their vitamin D receptor (VDR) associated-potencies as cholesterol lowering agents in mice in vivo. These precursors are activated in vivo: 1α(OH)D 3 and 1α(OH)D 2 are transformed by liver CYP2R1 and CYP27A1 to active VDR ligands, 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] and 1α,25-dihydroxyvitamin D 2 [1,25(OH) 2 D 2 ] , respectively. 1α(OH)D 2 may also be activated by CYP24A1 to 1α,24-dihydroxyvitamin D 2 [1,24(OH) 2 D 2 ], another active VDR ligand. 25(OH)D 3 , the metabolite formed via CYP2R1 and or CYP27A1 in liver from vitamin D 3 , is activated by CYP27B1 in the kidney to 1,25(OH) 2 D 3 . In C57BL/6 mice fed the high fat/high cholesterol Western diet for 3 weeks, vitamin D analogs were administered every other day intraperitoneally during the last week of the diet. The rank order for cholesterol lowering, achieved via mouse liver small heterodimer partner (Shp) inhibition and increased cholesterol 7α-hydroxylase (Cyp7a1) expression, was: 1.75 nmol/kg 1α(OH)D 3 > 1248 nmol/kg 25(OH)D 3 (dose ratio of 0.0014) > > 1625 nmol/kg vitamin D 3 . Except for 1.21 nmol/kg 1α(OH)D 2 that failed to lower liver and plasma cholesterol contents, a significant negative correlation was observed between the liver concentration of 1,25(OH) 2 D 3 formed from the precursors and liver cholesterol levels. The composite results show that vitamin D analogs 1α(OH)D 3 and 25(OH)D 3 exhibit cholesterol lowering properties upon activation to 1,25(OH) 2 D 3 : 1α(OH)D 3 is rapidly activated by liver enzymes and 25(OH)D 3 is slowly activated by renal Cyp27b1 in mouse. Copyright © 2018 John Wiley & Sons, Ltd.
D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860): candidates for 1D charmed-strange mesons
Energy Technology Data Exchange (ETDEWEB)
Song, Qin-Tao [Nuclear Theory Group, Institute of Modern Physics, Chinese Academy of Sciences, 730000, Lanzhou (China); Research Center for Hadron and CSR Physics, Lanzhou University & Institute of Modern Physics of CAS, 730000, Lanzhou (China); University of Chinese Academy of Sciences, 100049, Beijing (China); Chen, Dian-Yong, E-mail: chendy@impcas.ac.cn [Nuclear Theory Group, Institute of Modern Physics, Chinese Academy of Sciences, 730000, Lanzhou (China); Research Center for Hadron and CSR Physics, Lanzhou University & Institute of Modern Physics of CAS, 730000, Lanzhou (China); Liu, Xiang, E-mail: xiangliu@lzu.edu.cn [Research Center for Hadron and CSR Physics, Lanzhou University & Institute of Modern Physics of CAS, 730000, Lanzhou (China); School of Physical Science and Technology, Lanzhou University, 730000, Lanzhou (China); Matsuki, Takayuki, E-mail: matsuki@tokyo-kasei.ac.jp [Tokyo Kasei University, 1-18-1 Kaga, Itabashi, 173-8602, Tokyo (Japan); Theoretical Research Division, Nishina Center, RIKEN, 351-0198, Saitama (Japan)
2015-01-27
Newly observed two charmed-strange resonances, D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860), are investigated by calculating their Okubo–Zweig–Iizuka-allowed strong decays, which shows that they are suitable candidates for the 1{sup 3}D{sub 1} and 1{sup 3}D{sub 3} states in the charmed-strange meson family. Our study also predicts other main decay modes of D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860), which can be accessible at the future experiment. In addition, the decay behaviors of the spin partners of D{sub s1}{sup ∗}(2860) and D{sub s3}{sup ∗}(2860), i.e., 1D(2{sup -}) and 1D{sup ′}(2{sup -}), are predicted in this work, which are still missing at present. The experimental search for the missing 1D(2{sup -}) and 1D{sup ′}(2{sup -}) charmed-strange mesons is an intriguing and challenging task for further experiments.
International Nuclear Information System (INIS)
Fahleson, Tobias; Norman, Patrick; Coriani, Sonia; Rizzo, Antonio; Rikken, Geert L. J. A.
2013-01-01
We report on the results of a systematic ab initio study of the Jones birefringence of noble gases, of furan homologues, and of monosubstituted benzenes, in the gas phase, with the aim of analyzing the behavior and the trends within a list of systems of varying size and complexity, and of identifying candidates for a combined experimental/theoretical study of the effect. We resort here to analytic linear and nonlinear response functions in the framework of time-dependent density functional theory. A correlation is made between the observable (the Jones constant) and the atomic radius for noble gases, or the permanent electric dipole and a structure/chemical reactivity descriptor as the para Hammett constant for substituted benzenes
Ciret, Charles; Gorza, Simon-Pierre
2016-06-15
The scattering of a linear wave on an optical event horizon, induced by a cross-polarized soliton, is experimentally and numerically investigated in integrated structures. The experiments are performed in a dispersion-engineered birefringent silicon nanophotonic waveguide. In stark contrast with copolarized waves, the large difference between the group velocity of the two cross-polarized waves enables a frequency conversion almost independent of the soliton wavelength. It is shown that the generated idler is only shifted by 10 nm around 1550 nm over a pump tuning range of 350 nm. Simulations using two coupled full vectorial nonlinear Schrödinger equations fully support the experimental results.
Synthesis of 1-D ZnO nanorods and polypyrrole/1-D ZnO ...
Indian Academy of Sciences (India)
1-D ZnO nanorods and PPy/1-D ZnO nanocomposites were prepared by the surfactant-assisted precipitation and in situ polymerization method, respectively. The synthesized nanorods and nanocomposites were characterized by UV–Vis spectrophotometer, Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction ...
Microstates of D1–D5(-P) black holes, as interacting D-branes
Energy Technology Data Exchange (ETDEWEB)
Morita, Takeshi, E-mail: morita.takeshi@shizuoka.ac.jp [Department of Physics, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan); Shiba, Shotaro, E-mail: sshiba@cc.kyoto-su.ac.jp [Maskawa Institute for Science and Culture, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555 (Japan)
2015-07-30
In our previous study (Morita et al., 2014 [1]), we figured out that the thermodynamics of the near extremal black p-branes can be explained as the collective motions of gravitationally interacting elementary p-branes (the p-soup proposal). We test this proposal in the near-extremal D1–D5 and D1–D5-P black holes and show that their thermodynamics also can be explained in a similar fashion, i.e. via the collective motions of the interacting elementary D1-branes and D5-branes (and waves). It may imply that the microscopic origins of these intersecting black branes and the black p-brane are explained in the unified picture. We also argue the relation between the p-soup proposal and the conformal field theory calculations of the D1–D5(-P) black holes in superstring theory.
Microstates of D1–D5(-P black holes, as interacting D-branes
Directory of Open Access Journals (Sweden)
Takeshi Morita
2015-07-01
Full Text Available In our previous study (Morita et al., 2014 [1], we figured out that the thermodynamics of the near extremal black p-branes can be explained as the collective motions of gravitationally interacting elementary p-branes (the p-soup proposal. We test this proposal in the near-extremal D1–D5 and D1–D5-P black holes and show that their thermodynamics also can be explained in a similar fashion, i.e. via the collective motions of the interacting elementary D1-branes and D5-branes (and waves. It may imply that the microscopic origins of these intersecting black branes and the black p-brane are explained in the unified picture. We also argue the relation between the p-soup proposal and the conformal field theory calculations of the D1–D5(-P black holes in superstring theory.
Microstates of D1–D5(-P) black holes, as interacting D-branes
International Nuclear Information System (INIS)
Morita, Takeshi; Shiba, Shotaro
2015-01-01
In our previous study (Morita et al., 2014 [1]), we figured out that the thermodynamics of the near extremal black p-branes can be explained as the collective motions of gravitationally interacting elementary p-branes (the p-soup proposal). We test this proposal in the near-extremal D1–D5 and D1–D5-P black holes and show that their thermodynamics also can be explained in a similar fashion, i.e. via the collective motions of the interacting elementary D1-branes and D5-branes (and waves). It may imply that the microscopic origins of these intersecting black branes and the black p-brane are explained in the unified picture. We also argue the relation between the p-soup proposal and the conformal field theory calculations of the D1–D5(-P) black holes in superstring theory
Flood hazard assessment using 1D and 2D approaches
Petaccia, Gabriella; Costabile, Pierfranco; Macchione, Francesco; Natale, Luigi
2013-04-01
The EU flood risk Directive (Directive 2007/60/EC) prescribes risk assessment and mapping to develop flood risk management plans. Flood hazard mapping may be carried out with mathematical models able to determine flood-prone areas once realistic conditions (in terms of discharge or water levels) are imposed at the boundaries of the case study. The deterministic models are mainly based on shallow water equations expressed in their 1D or 2D formulation. The 1D approach is widely used, especially in technical studies, due to its relative simplicity, its computational efficiency and also because it requires topographical data not as expensive as the ones needed by 2D models. Even if in a great number of practical situations, such as modeling in-channel flows and not too wide floodplains, the 1D approach may provide results close to the prediction of a more sophisticated 2D model, it must be pointed out that the correct use of a 1D model in practical situations is more complex than it may seem. The main issues to be correctly modeled in a 1D approach are the definition of hydraulic structures such as bridges and buildings interacting with the flow and the treatment of the tributaries. Clearly all these aspects have to be taken into account also in the 2D modeling, but with fewer difficulties. The purpose of this paper is to show how the above cited issues can be described using a 1D or 2D unsteady flow modeling. In particular the Authors will show the devices that have to be implemented in 1D modeling to get reliable predictions of water levels and discharges comparable to the ones obtained using a 2D model. Attention will be focused on an actual river (Crati river) located in the South of Italy. This case study is quite complicated since it deals with the simulation of channeled flows, overbank flows, interactions with buildings, bridges and tributaries. Accurate techniques, intentionally developed by the Authors to take into account all these peculiarities in 1D and 2
Apyan, A.; Badelek, B.; Ballestrero, S.; Biino, C.; Birol, I.; Cenci, P.; Connell, S.H.; Eichblatt, S.; Fonseca, T.; Freund, A.; Gorini, B.; Groess, R.; Ispirian, K.; Ketel, T.J.; Kononets, Yu.V.; Lopez, A.; Mangiarotti, A.; van Rens, B.; Sellschop, J.P.F.; Shieh, M.; Sona, P.; Strakhovenko, V.; Uggerhoj, E.; Uggerhj, Ulrik Ingerslev; Unel, G.; Velasco, M.; Vilakazi, Z.Z.; Wessely, O.; Kononets, Yu.V.
2003-01-01
We present the first experimental results on the use of a thick aligned Si crystal acting as a quarter wave plate to induce a degree of circular polarisation in a high energy linearly polarised photon beam. The linearly polarised photon beam is produced from coherent bremsstrahlung radiation by 178 GeV unpolarised electrons incident on an aligned Si crystal, acting as a radiator. The linear polarisation of the photon beam is characterised by measuring the asymmetry in electron-positron pair production in a Ge crystal, for different crystal orientations. The Ge crystal therefore acts as an analyser. The birefringence phenomenon, which converts the linear polarisation to circular polarisation, is observed by letting the linearly polarised photons beam pass through a thick Si quarter wave plate crystal, and then measuring the asymmetry in electron-positron pair production again for a selection of relative angles between the crystallographic planes of the radiator, analyser and quarter wave plate. The systematics...
Measurements of vacuum magnetic birefringence using permanent dipole magnets: the PVLAS experiment
Della Valle, F.; Gastaldi, U.; Messineo, G.; Milotti, E.; Pengo, R.; Piemontese, L.; Ruoso, G.; Zavattini, G.
2013-05-01
The PVLAS collaboration is presently assembling a new apparatus (at the INFN section of Ferrara, Italy) to detect vacuum magnetic birefringence (VMB). VMB is related to the structure of the quantum electrodynamics (QED) vacuum and is predicted by the Euler-Heisenberg-Weisskopf effective Lagrangian. It can be detected by measuring the ellipticity acquired by a linearly polarized light beam propagating through a strong magnetic field. Using the very same optical technique it is also possible to search for hypothetical low-mass particles interacting with two photons, such as axion-like (ALP) or millicharged particles. Here we report the results of a scaled-down test setup and describe the new PVLAS apparatus. This latter is in construction and is based on a high-sensitivity ellipsometer with a high-finesse Fabry-Perot cavity (>4 × 105) and two 0.8 m long 2.5 T rotating permanent dipole magnets. Measurements with the test setup have improved, by a factor 2, the previous upper bound on the parameter Ae, which determines the strength of the nonlinear terms in the QED Lagrangian: A(PVLAS)e < 3.3 × 10-21 T-2 at 95% c.l. Furthermore, new laboratory limits have been put on the inverse coupling constant of ALPs to two photons and confirmation of previous limits on the fractional charge of millicharged particles is given.
Mixing between the 23S1 and 13D1 Ds
International Nuclear Information System (INIS)
Yuan Ling; Chen Bing; Zhang Ailin
2013-01-01
Mixing between the 2 3 S 1 and 1 3 D 1 D s is studied within the 3 P 0 model. If mixing between these two 1 - states exists, D s1 * (2700)± and D sJ * (2860)± could be interpreted as the two orthogonal mixed states with mixing angle θ≈-80° in the case of a special β for each meson. However, in the case of a universal β for all mesons, D s1 * (2700)± could be interpreted as the mixed state of 2 3 S 1 and 1 3 D 1 with mixing angle 12° < θ < 21° but D s * J (2860) ± seems difficult to interpret as the orthogonal partner of D s1 * (2700) ± . (authors)
dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.
Chavez, Joselyn; Murillo-Maldonado, Juan Manuel; Bahena, Vanessa; Cruz, Ana Karina; Castañeda-Sortibrán, América; Rodriguez-Arnaiz, Rosario; Zurita, Mario; Valadez-Graham, Viviana
2017-12-01
Telomeres are important contributors to genome stability, as they prevent linear chromosome end degradation and contribute to the avoidance of telomeric fusions. An important component of the telomeres is the heterochromatin protein 1a (HP1a). Mutations in Su(var)205, the gene encoding HP1a in Drosophila, result in telomeric fusions, retrotransposon regulation loss and larger telomeres, leading to chromosome instability. Previously, it was found that several proteins physically interact with HP1a, including dXNP and dAdd1 (orthologues to the mammalian ATRX gene). In this study, we found that mutations in the genes encoding the dXNP and dAdd1 proteins affect chromosome stability, causing chromosomal aberrations, including telomeric defects, similar to those observed in Su(var)205 mutants. In somatic cells, we observed that dXNP and dAdd1 participate in the silencing of the telomeric HTT array of retrotransposons, preventing anomalous retrotransposon transcription and integration. Furthermore, the lack of dAdd1 results in the loss of HP1a from the telomeric regions without affecting other chromosomal HP1a binding sites; mutations in dxnp also affected HP1a localization but not at all telomeres, suggesting a specialized role for dAdd1 and dXNP proteins in locating HP1a at the tips of the chromosomes. These results place dAdd1 as an essential regulator of HP1a localization and function in the telomere heterochromatic domain.
Meier-Abt, F; Hammann-Hänni, A; Stieger, B; Ballatori, N; Boyer, J L
2007-02-01
Organic anion transporting polypeptides (rodent Oatp; human OATP) mediate cellular uptake of numerous organic compounds including xenobiotic toxins into mammalian hepatocytes. In the little skate Leucoraja erinacea a liver-specific Oatp (Oatp1d1, also called sOatp) has been identified and suggested to represent an evolutionarily ancient precursor of the mammalian liver OATP1B1 (human), Oatp1b2 (rat), and OATP1B3 (human). The present study tested whether Oatp1d1 shares functional transport activity of the xenobiotic oligopeptide toxins phalloidin and microcystin with the mammalian liver Oatps/OATPs. The phalloidin analogue [(3)H]-demethylphalloin was taken up into skate hepatocytes with high affinity (Km approximately 0.4 microM), and uptake could be inhibited by phalloidin and a variety of typical Oatp/OATP substrates such as bromosulfophthalein, bile salts, estrone-3-sulfate, cyclosporine A and high concentrations of microcystin-LR (Ki approximately 150 microM). When expressed in Xenopus laevis oocytes Oatp1d1 increased uptake of demethylphalloin (Km approximately 2.2 microM) and microcystin-LR (Km approximately 27 microM) 2- to 3-fold over water-injected oocytes, whereas the alternative skate liver organic anion transporter, the dimeric Ostalpha/beta, exhibited no phalloidin and only minor microcystin-LR transport. Also, the closest mammalian Oatp1d1 orthologue, the human brain and testis OATP1C1, did not show any phalloidin transport activity. These results demonstrate that the evolutionarily ancient Oatp1d1 is able to mediate uptake of cyclic oligopeptide toxins into skate liver. The findings support the notion that Oatp1d1 is a precursor of the liver-specific mammalian Oatps/OATPs and that its transport properties are closely associated with certain forms of toxic liver injury such as for example protein phosphatase inhibition by the water-borne toxin microcystin.
International Nuclear Information System (INIS)
Meier-Abt, F.; Hammann-Haenni, A.; Stieger, B.; Ballatori, N.; Boyer, J.L.
2007-01-01
Organic anion transporting polypeptides (rodent Oatp; human OATP) mediate cellular uptake of numerous organic compounds including xenobiotic toxins into mammalian hepatocytes. In the little skate Leucoraja erinacea a liver-specific Oatp (Oatp1d1, also called sOatp) has been identified and suggested to represent an evolutionarily ancient precursor of the mammalian liver OATP1B1 (human), Oatp1b2 (rat), and OATP1B3 (human). The present study tested whether Oatp1d1 shares functional transport activity of the xenobiotic oligopeptide toxins phalloidin and microcystin with the mammalian liver Oatps/OATPs. The phalloidin analogue [ 3 H]-demethylphalloin was taken up into skate hepatocytes with high affinity (Km ∼ 0.4 μM), and uptake could be inhibited by phalloidin and a variety of typical Oatp/OATP substrates such as bromosulfophthalein, bile salts, estrone-3-sulfate, cyclosporine A and high concentrations of microcystin-LR (Ki ∼ 150 μM). When expressed in Xenopus laevis oocytes Oatp1d1 increased uptake of demethylphalloin (Km ∼ 2.2 μM) and microcystin-LR (Km ∼ 27 μM) 2- to 3-fold over water-injected oocytes, whereas the alternative skate liver organic anion transporter, the dimeric Ostα/β, exhibited no phalloidin and only minor microcystin-LR transport. Also, the closest mammalian Oatp1d1 orthologue, the human brain and testis OATP1C1, did not show any phalloidin transport activity. These results demonstrate that the evolutionarily ancient Oatp1d1 is able to mediate uptake of cyclic oligopeptide toxins into skate liver. The findings support the notion that Oatp1d1 is a precursor of the liver-specific mammalian Oatps/OATPs and that its transport properties are closely associated with certain forms of toxic liver injury such as for example protein phosphatase inhibition by the water-borne toxin microcystin
Underground storage tank 291-D1U1: Closure plan
Energy Technology Data Exchange (ETDEWEB)
Mancieri, S.; Giuntoli, N.
1993-09-01
The 291-D1U1 tank system was installed in 1983 on the north side of Building 291. It supplies diesel fuel to the Building 291 emergency generator and air compressor. The emergency generator and air compressor are located southwest and southeast, respectively, of the tank (see Appendix B, Figure 2). The tank system consists of a single-walled, 2,000- gallon, fiberglass tank and a fuel pump system, fill pipe, vent pipe, electrical conduit, and fuel supply and return piping. The area to be excavated is paved with asphalt and concrete. It is not known whether a concrete anchor pad is associated with this tank. Additionally, this closure plan assumes that the diesel tank is below the fill pad. The emergency generator and air compressor for Building 291 and its associated UST, 291-D1U1, are currently in use. The generator and air compressor will be supplied by a temporary above-ground fuel tank prior to the removal of 291-D1U1. An above-ground fuel tank will be installed as a permanent replacement for 291-D1U1. The system was registered with the State Water Resources Control Board on June 27, 1984, as 291-41D and has subsequently been renamed 291-D1U1. Figure 1 (see Appendix B) shows the location of the 291-D1U1 tank system in relation to the Lawrence Livermore National Laboratory (LLNL). Figure 2 (see Appendix B) shows the 291-D1U1 tank system in relation to Building 291. Figure 3 (see Appendix B) shows a plan view of the 291-D1U1 tank system.
Realization of low loss and polarization maintaining hollow core photonic crystal fibers
DEFF Research Database (Denmark)
Mangan, Brian Joseph; Lyngsøe, Jens Kristian; Roberts, John
2008-01-01
Antiresonant core wals in 7-cell hollow core fibers are used to reduce the attenuation to 9.3dB/km and create an intentionally hightly birefringent fiber with a beatlength as low as 0.2mm......Antiresonant core wals in 7-cell hollow core fibers are used to reduce the attenuation to 9.3dB/km and create an intentionally hightly birefringent fiber with a beatlength as low as 0.2mm...
DEFF Research Database (Denmark)
Jacque, C M; Baumann, N A; Bock, E
1976-01-01
Seven antigens specific to the nervous tissue were measured in both Jimpy and control mice. The D5 and the GFA protein, both components of the glia, are strongly increased in the mutant while the neuronal components 14-3-2, synaptin C1, D1, D2 and D3 are unchanged....
26 CFR 1.45D-1 - New markets tax credit.
2010-04-01
... 26 Internal Revenue 1 2010-04-01 2010-04-01 true New markets tax credit. 1.45D-1 Section 1.45D-1... Computing Credit for Investment in Certain Depreciable Property § 1.45D-1 New markets tax credit. (a) Table... of new markets tax credit (B) Recapture event (ii) CDE reporting requirements to Secretary (iii...
26 CFR 1.860D-1 - Definition of a REMIC.
2010-04-01
... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Definition of a REMIC. 1.860D-1 Section 1.860D-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860D-1 Definition of a REMIC. (a) In general. A real...
Treebak, Jonas T; Pehmøller, Christian; Kristensen, Jonas M; Kjøbsted, Rasmus; Birk, Jesper B; Schjerling, Peter; Richter, Erik A; Goodyear, Laurie J; Wojtaszewski, Jørgen F P
2014-01-15
We investigated the phosphorylation signatures of two Rab-GTPase activating proteins TBC1D1 and TBC1D4 in human skeletal muscle in response to physical exercise and physiological insulin levels induced by a carbohydrate rich meal using a paired experimental design. Eight healthy male volunteers exercised in the fasted or fed state and muscle biopsies were taken before and immediately after exercise. We identified TBC1D1/4 phospho-sites that (1) did not respond to exercise or postprandial increase in insulin (TBC1D4: S666), (2) responded to insulin only (TBC1D4: S318), (3) responded to exercise only (TBC1D1: S237, S660, S700; TBC1D4: S588, S751), and (4) responded to both insulin and exercise (TBC1D1: T596; TBC1D4: S341, T642, S704). In the insulin-stimulated leg, Akt phosphorylation of both T308 and S473 correlated significantly with multiple sites on both TBC1D1 (T596) and TBC1D4 (S318, S341, S704). Interestingly, in the exercised leg in the fasted state TBC1D1 phosphorylation (S237, T596) correlated significantly with the activity of the α2/β2/γ3 AMPK trimer, whereas TBC1D4 phosphorylation (S341, S704) correlated with the activity of the α2/β2/γ1 AMPK trimer. Our data show differential phosphorylation of TBC1D1 and TBC1D4 in response to physiological stimuli in human skeletal muscle and support the idea that Akt and AMPK are upstream kinases. TBC1D1 phosphorylation signatures were comparable between in vitro contracted mouse skeletal muscle and exercised human muscle, and we show that AMPK regulated phosphorylation of these sites in mouse muscle. Contraction and exercise elicited a different phosphorylation pattern of TBC1D4 in mouse compared with human muscle, and although different circumstances in our experimental setup may contribute to this difference, the observation exemplifies that transferring findings between species is problematic.
Exercise increases TBC1D1 phosphorylation in human skeletal muscle
Jessen, Niels; An, Ding; Lihn, Aina S.; Nygren, Jonas; Hirshman, Michael F.; Thorell, Anders
2011-01-01
Exercise and weight loss are cornerstones in the treatment and prevention of type 2 diabetes, and both interventions function to increase insulin sensitivity and glucose uptake into skeletal muscle. Studies in rodents demonstrate that the underlying mechanism for glucose uptake in muscle involves site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 (TBC1D4) and TBC1D1. Multiple kinases, including Akt and AMPK, phosphorylate TBC1D1 and AS160 on distinct residues, regulating their activity and allowing for GLUT4 translocation. In contrast to extensive rodent-based studies, the regulation of AS160 and TBC1D1 in human skeletal muscle is not well understood. In this study, we determined the effects of dietary intervention and a single bout of exercise on TBC1D1 and AS160 site-specific phosphorylation in human skeletal muscle. Ten obese (BMI 33.4 ± 2.4, M-value 4.3 ± 0.5) subjects were studied at baseline and after a 2-wk dietary intervention. Muscle biopsies were obtained from the subjects in the resting (basal) state and immediately following a 30-min exercise bout (70% V̇o2 max). Muscle lysates were analyzed for AMPK activity and Akt phosphorylation and for TBC1D1 and AS160 phosphorylation on known or putative AMPK and Akt sites as follows: AS160 Ser711 (AMPK), TBC1D1 Ser231 (AMPK), TBC1D1 Ser660 (AMPK), TBC1D1 Ser700 (AMPK), and TBC1D1 Thr590 (Akt). The diet intervention that consisted of a major shift in the macronutrient composition resulted in a 4.2 ± 0.4 kg weight loss (P < 0.001) and a significant increase in insulin sensitivity (M value 5.6 ± 0.6), but surprisingly, there was no effect on expression or phosphorylation of any of the muscle-signaling proteins. Exercise increased muscle AMPKα2 activity but did not increase Akt phosphorylation. Exercise increased phosphorylation on AS160 Ser711, TBC1D1 Ser231, and TBC1D1 Ser660 but had no effect on TBC1D1 Ser700. Exercise did not increase TBC1D1 Thr590 phosphorylation or TBC1D1/AS160 PAS
Yavuz, Aykut Evren; Masalci, Özgür; Kazanci, Nadide
2014-11-01
Morphological properties of tetradecyltrimethylammonium bromide (TTAB) + water + octanol system in different concentrations have been studied. In the process, isotropic phase (L1) and nematic calamitic (NC), nematic discotic (ND), hexagonal E and lamellar D anizotropic mesophases have been determined by polarizing microscopy method and partial ternary phase diagram of the system set up. Textural properties of the anisotropic mesophases of the system have been discussed and their birefringence values measured. Mechanical deformation has been applied to the mesophases. The textural properties and the birefringence values have been observed to be changed by the deformation, after and before which changes have been compared.
Design, synthesis, and characterization of 0-D, 1-D, and 2-D Zinc–Adeninate coordination assemblies
Energy Technology Data Exchange (ETDEWEB)
An, Ji Hyun [Dept. of Chemistry Education, Seoul National University, Seoul (Korea, Republic of); Geib, Steven J. [Dept. of Chemistry, University of Pittsburgh, Pittsburgh (United States); Kim, Myung Gil [Dept. of Chemistry, Chungang University, Seoul (Korea, Republic of)
2015-08-15
In this study, we demonstrate the synthesis and characterization of zinc– adeninate coordination polymers with 0-D, 1-D, and 2-D structures. We describe methods for controlling the structure of these materials by applying different synthetic conditions and discuss their structural relationships. 0-D, 1-D, and 2-D zinc–adeninate coordination polymers with the same metal–adeninate coordination mode were synthesized and characterized. By controlling the temperature, a material with 0-D macrocycle or 1-D chain coordination polymer was prepared. A replacement of pyridine with bipyridine formed 2-D sheet structure by connecting 1-D chains with each other. They exhibited an interesting relationship between synthetic methods and structures. Further study of metal–adeninate coordination chemistry will render a precise control of the structure in synthesis and will open a new venue to new materials with fascinating properties.
Production of the excited charm mesons D1 and D*2 at HERA
International Nuclear Information System (INIS)
Verbytskyi, Andrii
2013-02-01
The production of the excited charm mesons D 1 , D * 2 and D + s1 in ep collisions has been measured with the ZEUS detector at Hera. The data sample taken by the ZEUS detector in the years 2003-2007, corresponding to an integrated luminosity of 373 pb -1 has been used. The masses of the neutral, charged and strange states, the widths of the neutral states, the helicity parameters of D 0 1 and D + s1 were determined and compared with other measurements and with theoretical expectations. The measured helicity parameters of the D 0 1 and D + s1 allows for some mixing of S- and D-waves in their decays to D *± π -+ and D *± K 0 respectively. The measured value of the D 0 1 helicity parameter is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D *0 2 , D *± 2 and D + s1 states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D 1 , D * 2 and D + s1 were measured and are consistent with those obtained in e + e - annihilations. The Grid computing technology has a high importance for modern High Energy Physics. This technology has been successfully used in Zeus experiment for the MC simulations and data analysis. The dedicated infrastructure has been maintained by the author since 2010. In addition to continuous support, the author has upgraded and improved the performance of the Grid MC simulations and contributed to the Zeus data preservation project.
DEFF Research Database (Denmark)
Agoston, Karoly; Dekany, Gyula; Lundt, Inge
2009-01-01
Four novel disaccharides of glycosylated 1,5-anhydro-D-ketoses have been prepared: 1,5-anhydro-4-O-b-D-glucopyranosyl-D-fructose, 1,5-anhydro-4-O-b-D-galactopyranosyl-D-fructose, 1,5-anhydro-4-O-b-D-glucopyranosyl-D-tagatose and 1,5-anhydro-4-O-b-D-galactopyranosyl-D-tagatose. The common...... intermediate, 1,5-anhydro-2,3-O-isopropylidene-b-D-fructopyranose, was prepared from D-fructose and converted into the D-tagatose derivative by oxidation followed by stereoselective reduction to the 4-epimer. The prepared anhydro-ketoses were glycosylated and deprotected to the disaccharides....
Agoston, Károly; Dékány, Gyula; Lundt, Inge
2009-05-26
Four novel disaccharides of glycosylated 1,5-anhydro-D-ketoses have been prepared: 1,5-anhydro-4-O-beta-D-glucopyranosyl-D-fructose, 1,5-anhydro-4-O-beta-D-galactopyranosyl-D-fructose, 1,5-anhydro-4-O-beta-D-glucopyranosyl-D-tagatose, and 1,5-anhydro-4-O-beta-D-galactopyranosyl-D-tagatose. The common intermediate, 1,5-anhydro-2,3-O-isopropylidene-beta-D-fructopyranose, was prepared from D-fructose and was converted into the D-tagatose derivative by oxidation followed by stereoselective reduction to the 4-epimer. The anhydroketoses thus prepared were glycosylated and deprotected to give the disaccharides.
Cyclin D1 expression in prostate carcinoma
Energy Technology Data Exchange (ETDEWEB)
Pereira, R.A.; Ravinal, R.C.; Costa, R.S.; Lima, M.S. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Patologia, Ribeirão Preto, SP, Brasil, Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Tucci, S. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Cirurgia e Anatomia, Divisão de Urologia, Ribeirão Preto, SP, Brasil, Divisão de Urologia, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Muglia, V.F. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Medicina Interna (Centro de Ciência da Imagem), Ribeirão Preto, SP, Brasil, Departamento de Medicina Interna (Centro de Ciência da Imagem), Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Reis, R.B. Dos [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Cirurgia e Anatomia, Divisão de Urologia, Ribeirão Preto, SP, Brasil, Divisão de Urologia, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Silva, G.E.B. [Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Patologia, Ribeirão Preto, SP, Brasil, Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil)
2014-05-09
The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved from autopsies. We measured nuclear immunostaining in the entire tumor area and based the results on the percentage of positive tumor cells. The preoperative prostate-specific antigen (PSA) level was 8.68±5.16 ng/mL (mean±SD). Cyclin D1 staining was positive (cyclin D1 expression in >5% of tumor cells) in 64 cases (75.4%) and negative (cyclin D1 expression in ≤5% of tumor cells) in 21 cases (including 15 cases with no immunostaining). Normal prostate tissues were negative for cyclin D1. Among patients with a high-grade Gleason score (≥7), 86% of patients demonstrated cyclin D1 immunostaining of >5% (P<0.05). In the crude analysis of cyclin D1 expression, the high-grade Gleason score group showed a mean expression of 39.6%, compared to 26.9% in the low-grade Gleason score group (P<0.05). Perineural invasion tended to be associated with cyclin D1 expression (P=0.07), whereas cyclin D1 expression was not associated with PSA levels or other parameters. Our results suggest that high cyclin D1 expression could be a potential marker for tumor aggressiveness.
Cyclin D1 expression in prostate carcinoma
International Nuclear Information System (INIS)
Pereira, R.A.; Ravinal, R.C.; Costa, R.S.; Lima, M.S.; Tucci, S.; Muglia, V.F.; Reis, R.B. Dos; Silva, G.E.B.
2014-01-01
The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved from autopsies. We measured nuclear immunostaining in the entire tumor area and based the results on the percentage of positive tumor cells. The preoperative prostate-specific antigen (PSA) level was 8.68±5.16 ng/mL (mean±SD). Cyclin D1 staining was positive (cyclin D1 expression in >5% of tumor cells) in 64 cases (75.4%) and negative (cyclin D1 expression in ≤5% of tumor cells) in 21 cases (including 15 cases with no immunostaining). Normal prostate tissues were negative for cyclin D1. Among patients with a high-grade Gleason score (≥7), 86% of patients demonstrated cyclin D1 immunostaining of >5% (P<0.05). In the crude analysis of cyclin D1 expression, the high-grade Gleason score group showed a mean expression of 39.6%, compared to 26.9% in the low-grade Gleason score group (P<0.05). Perineural invasion tended to be associated with cyclin D1 expression (P=0.07), whereas cyclin D1 expression was not associated with PSA levels or other parameters. Our results suggest that high cyclin D1 expression could be a potential marker for tumor aggressiveness
Deyama, Satoshi; Ishikawa, Yuka; Yoshikawa, Kotomi; Shimoda, Kento; Ide, Soichiro; Satoh, Masamichi; Minami, Masabumi
2017-07-01
Resolvin D1 and D2 are bioactive lipid mediators that are generated from docosahexaenoic acid. Although recent preclinical studies suggest that these compounds have antidepressant effects, their mechanisms of action remain unclear. We investigated mechanisms underlying the antidepressant effects of resolvin D1 and resolvin D2 in lipopolysaccharide (0.8 mg/kg, i.p.)-induced depression model mice using a tail suspension test. I.c.v. infusion of resolvin D1 (10 ng) and resolvin D2 (10 ng) produced antidepressant effects; these effects were significantly blocked by a resolvin D1 receptor antagonist WRW4 (10 µg, i.c.v.) and a resolvin D2 receptor antagonist O-1918 (10 µg, i.c.v.), respectively. The mammalian target of rapamycin complex 1 inhibitor rapamycin (10 mg/kg, i.p.) and a mitogen-activated protein kinase kinase inhibitor U0126 (5 µg, i.c.v.) significantly blocked the antidepressant effects of resolvin D1 and resolvin D2. An AMPA receptor antagonist NBQX (10 mg/kg, i.p.) and a phosphoinositide 3-kinase inhibitor LY294002 (3 µg, i.c.v.) blocked the antidepressant effects of resolvin D1 significantly, but not of resolvin D2. Bilateral infusions of resolvin D1 (0.3 ng/side) or resolvin D2 (0.3 ng/side) into the medial prefrontal cortex or dentate gyrus of the hippocampus produced antidepressant effects. These findings demonstrate that resolvin D1 and resolvin D2 produce antidepressant effects via the mammalian target of rapamycin complex 1 signaling pathway, and that the medial prefrontal cortex and dentate gyrus are important brain regions for these antidepressant effects. These compounds and their receptors may be promising targets for the development of novel rapid-acting antidepressants, like ketamine and scopolamine. © The Author 2017. Published by Oxford University Press on behalf of CINP.
26 CFR 1.678(d)-1 - Renunciation of power.
2010-04-01
... (CONTINUED) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.678(d)-1 Renunciation of power. Section 678(a) does not apply to a power which has been renounced or disclaimed within a reasonable time... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Renunciation of power. 1.678(d)-1 Section 1.678...
Sariñana, Joshua; Tonegawa, Susumu
2017-01-01
Activation of prefrontal cortical (PFC), striatal, and hippocampal dopamine 1-class receptors (D1R and D5R) is necessary for normal spatial information processing. Yet the precise role of the D1R versus the D5R in the aforementioned structures, and their specific contribution to the water-maze spatial learning task remains unknown. D1R- and D5R- specific in situ hybridization probes showed that forebrain restricted D1R and D5R KO mice (F-D1R/D5R KO) displayed D1R mRNA deletion in the medial (m)PFC, dorsal and ventral striatum, and the dentate gyrus (DG) of the hippocampus. D5R mRNA deletion was limited to the mPFC, the CA1 and DG hippocampal subregions. F-D1R/D5R KO mice were given water-maze training and displayed subtle spatial latency differences between genotypes and spatial memory deficits during both regular and reversal training. To differentiate forebrain D1R from D5R activation, forebrain restricted D1R KO (F-D1R KO) and D5R KO (F-D5R KO) mice were trained on the water-maze task. F-D1R KO animals exhibited escape latency deficits throughout regular and reversal training as well as spatial memory deficits during reversal training. F-D1R KO mice also showed perseverative behavior during the reversal spatial memory probe test. In contrast, F-D5R KO animals did not present observable deficits on the water-maze task. Because F-D1R KO mice showed water-maze deficits we tested the necessity of hippocampal D1R activation for spatial learning and memory. We trained DG restricted D1R KO (DG-D1R KO) mice on the water-maze task. DG-D1R KO mice did not present detectable spatial memory deficit, but did show subtle deficits during specific days of training. Our data provides evidence that forebrain D5R activation plays a unique role in spatial learning and memory in conjunction with D1R activation. Moreover, these data suggest that mPFC and striatal, but not DG D1R activation are essential for spatial learning and memory. PMID:26174222
Cyclin D1, Id1 and EMT in breast cancer
International Nuclear Information System (INIS)
Tobin, Nicholas P; Sims, Andrew H; Lundgren, Katja L; Lehn, Sophie; Landberg, Göran
2011-01-01
Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer cells with concomitant increase in 'inhibitor of differentiation 1' (ID1) gene expression. Id1 is known to be associated with more invasive features of cancer and with the epithelial-mesenchymal transition (EMT). Here, we sought to determine if the increase in cell motility following cyclin D1 silencing was mediated by Id1 and enhanced EMT-features. To further substantiate these findings we aimed to delineate the link between CCND1, ID1 and EMT, as well as clinical properties in primary breast cancer. Protein and gene expression of ID1, CCND1 and EMT markers were determined in MDA-MB-231 and ZR75 cells by western blot and qPCR. Cell migration and promoter occupancy were monitored by transwell and ChIP assays, respectively. Gene expression was analysed from publicly available datasets. The increase in cell migration following cyclin D1 silencing in MDA-MB-231 cells was abolished by Id1 siRNA treatment and we observed cyclin D1 occupancy of the Id1 promoter region. Moreover, ID1 and SNAI2 gene expression was increased following cyclin D1 knock-down, an effect reversed with Id1 siRNA treatment. Similar migratory and SNAI2 increases were noted for the ER-positive ZR75-1 cell line, but in an Id1-independent manner. In a meta-analysis of 1107 breast cancer samples, CCND1 low /ID1 high tumours displayed increased expression of EMT markers and were associated with reduced recurrence free survival. Finally, a greater percentage of CCND1 low /ID1 high tumours were found in the EMT-like 'claudin-low' subtype of breast cancer than in other subtypes. These results indicate that increased migration of MDA-MB-231 cells following cyclin D1 silencing can be mediated by Id
Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis
Directory of Open Access Journals (Sweden)
Maryam Mukhtar
2017-01-01
Full Text Available Background. The vitamin D receptor (VDR gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. Polymorphism in VDR causes alterations in the functioning of vitamin D, leading to type 1 diabetes (T1D predisposition. The aim of the present study was to determine VDR gene polymorphism in association with T1D in Pakistanis. Methods. The association was evaluated by selecting rs2228570 (FokΙ, rs7975232 (ApaΙ, and rs731236 (TaqΙ polymorphic sites in 102 patients and 100 controls. Genotypes were identified by DNA sequencing and PCR-RFLP. Results. The allelic and genotypic frequencies of FokΙ and ApaI were significantly associated with T1D (p0.05. CCGC, CCGG, CCTC, and CCTG haplotypes were significantly associated with disease development (p<0.05. However, CTGG haplotype was protective towards T1D (p<0.01. Conclusion. VDR polymorphisms were identified as susceptible regions for T1D development in the Pakistani population.
26 CFR 1.1402(d)-1 - Employee and wages.
2010-04-01
... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Employee and wages. 1.1402(d)-1 Section 1.1402... (CONTINUED) INCOME TAXES Tax on Self-Employment Income § 1.1402(d)-1 Employee and wages. For the purpose of the tax on self-employment income, the term “employee” and the term “wages” shall have the same...
D1/D5 systems in N=4 string theories
International Nuclear Information System (INIS)
Gava, Edi; Hammou, Amine B.; Morales, Jose F.; Narain, Kumar S.
2001-01-01
We propose CFT descriptions of the D1/D5 system in a class of freely acting Z 2 orbifolds/orientifolds of type IIB theory, with sixteen unbroken supercharges. The CFTs describing D1/D5 systems involve N=(4,4) or N=(4,0) sigma models on (R 3 xS 1 xT 4 x(T 4 ) N /S N )/Z 2 , where the action of Z 2 is diagonal and its precise nature depends on the model. We also discuss D1(D5)-brane states carrying non-trivial Kaluza-Klein charges, which correspond to excitations of two-dimensional CFTs of the type (R 3 xS 1 xT 4 ) N /S N xZ 2 N . The resulting multiplicities for two-charge bound states are shown to agree with the predictions of U-duality. We raise a puzzle concerning the multiplicities of three-charge systems, which is generically present in all vacuum configurations with sixteen unbroken supercharges studied so far, including the more familiar type IIB on K3 case: the constraints put on BPS counting formulae by U-duality are apparently in contradiction with any CFT interpretation. We argue that the presence of RR backgrounds appearing in the symmetric product CFT may provide a resolution of this puzzle. Finally, we show that the whole tower of D-instanton corrections to certain 'BPS saturated couplings' in the low energy effective actions match with the corresponding one-loop threshold corrections on the dual fundamental string side
Design of a kJ-class HiLASE laser as a driver for inertial fusion energy
Czech Academy of Sciences Publication Activity Database
Lucianetti, Antonio; Sawicka, Magdalena; Slezák, Ondřej; Divoký, Martin; Pilař, Jan; Jambunathan, Venkatesan; Bonora, Stefano; Antipenkov, Roman; Mocek, Tomáš
2014-01-01
Roč. 2, e13 (2014), s. 1-10 ISSN 2095-4719 R&D Projects: GA MŠk ED1.1.00/02.0061 Grant - others:ELI Beamlines(XE) CZ.1.05/1.1.00/02.0061 Institutional support: RVO:68378271 Keywords : ASE * birefringence * cryogenic cooling * slab lasers * thermooptic effects Subject RIV: BH - Optics, Masers, Lasers
Vitamin D and 1,25(OH2D Regulation of T cells
Directory of Open Access Journals (Sweden)
Margherita T. Cantorna
2015-04-01
Full Text Available Vitamin D is a direct and indirect regulator of T cells. The mechanisms by which vitamin D directly regulates T cells are reviewed and new primary data on the effects of 1,25 dihydroxyvitamin D (1,25(OH2D on human invariant natural killer (iNKT cells is presented. The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-γ, IL-17 and induction of IL-4. Experiments in mice demonstrate that the effectiveness of 1,25(OH2D requires NKT cells, IL-10, the IL-10R and IL-4. Comparisons of mouse and human T cells show that 1,25(OH2D inhibits IL-17 and IFN-γ, and induces T regulatory cells and IL-4. IL-4 was induced by 1,25(OH2D in mouse and human iNKT cells. Activation for 72h was required for optimal expression of the vitamin D receptor (VDR in human and mouse T and iNKT cells. In addition, T cells are potential autocrine sources of 1,25(OH2D but again only 48–72h after activation. Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-γ, while inducing IL-4 and IL-10, would be beneficial.
International Nuclear Information System (INIS)
Yanqiu Zhu, Y.; Ma, R.; Whitby, R.; Acquah, S.
2013-01-01
We witnessed an initial hyped period and enthusiasm on carbon nano tubes in the 1990s later went through a significant expansion into nano tubes of other materials (metal di chalcogenides, boron nitride, etc.) as well as various nano wires and nano rods. While much of the hype might have gone, the research on one-dimensional (1D) nano materials has matured as one of the most active research areas within the nano science and nano technology community, flourishing with ample, exciting, and new research opportunities. Just like any other research frontier, researchers working in the 1D nano materials field are constantly striving to develop new fundamental science as well as potential applications. It remains a common belief that versatility and tunability of 1D nano materials would challenge many new rising tasks coming from our resource and energy demanding modern society. The traditional semiconductor industry has produced so many devices and systems from transistors, sensors, lasers, and LEDs to more sophisticated solar panels, which are now part of our daily lives. By down sizing the core components or parts to 1D form, one might wonder how fundamentally the dimensionality and morphology would impact the device performance, this is, as always, requiring us to fully understand the structure-property relationship in 1D nano materials. It may be equally crucial in connecting discovery-driven fundamental science to market-driven technology industry concerning potentially relevant findings derived from these novel materials. The importance of a platform that allows active researchers in this field to present their new development in a timely and efficient manner is therefore self-evident. Following the success of two early special issues devoted to 1D nano materials, this is the third one in a row organized by the same group of guest editors, attesting that such a platform has been well received by the readers
Production of the excited charm mesons D1 and D*2 at HERA
International Nuclear Information System (INIS)
Abramowicz, H.; Abt, I.; Adamczyk, L.
2012-08-01
The production of the excited charm mesons D 1 (2420) and D * 2 (2460) in ep collisions has been measured with the ZEUS detector at HERA using an integrated luminosity of 373 pb -1 . The masses of the neutral and charged states, the widths of the neutral states, and the helicity parameter of D 1 (2420) 0 were determined and compared with other measurements and with theoretical expectations. The measured helicity parameter of the D 0 1 allows for some mixing of S- and D-waves in its decay to D *± π -+ . The result is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D * 2 (2460) 0 and D * 2 (2460) ± states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D 1 and D * 2 were measured and are consistent with those obtained in e + e - annihilations.
Social exploration of 1D games
DEFF Research Database (Denmark)
Valente, Andrea; Marchetti, Emanuela
2013-01-01
In this paper the apparently meaningless concept of a 1 dimensional computer game is explored, via netnography. A small number of games was designed and implemented, in close contact with online communities of players and developers, providing evidence that 1 dimension is enough to produce...... interesting gameplay, to allow for level design and even to leave room for artistic considerations on 1D rendering. General techniques to re-design classic 2D games into 1D are also emerging from this exploration....
Directory of Open Access Journals (Sweden)
Nina eWeishaupt
2015-12-01
Full Text Available GM1 ganglioside plays a role in essential neuronal processes, including differentiation, survival and signaling. Yet, little is known about GM1 species with different sphingosine bases, such as the most abundant species containing 18 carbon atoms in the sphingosine chain (GM1d18:1, and the less abundant containing 20 carbon atoms (GM1d20:1. While absent in the early fetal brain, GM1d20:1 continues to increase throughout pre- and postnatal development and into old age, raising questions about the functional relevance of the GM1d18:1 to GM1d20:1 ratio. Matrix-assisted laser desorption/ionization (MALDI Imaging Mass Spectrometry is a novel technology that allows differentiation between these two GM1 species and quantification of their expression within an anatomical context. Using this technology, we find GM1d18:1/d20:1 expression ratios are highly specific to defined anatomical brain regions in adult rats. Thus, the ratio was significantly different among different thalamic nuclei and between the corpus callosum and internal capsule. Differential GM1d18:1/GM1d20:1 ratios measured in hippocampal subregions in rat brain complement previous studies conducted in mice. Across layers of the sensory cortex, opposing expression gradients were found for GM1d18:1 and GM1d20:1. Superficial layers demonstrated lower GM1d18:1 and higher GM1d20:1 signal than other layers, while in deep layers GM1d18:1 expression was relatively high and GM1d20:1 expression low. By far the highest GM1d18:1/d20:1 ratio was found in the amygdala. Differential expression of GM1 with d18:1- or d20:1-sphingosine bases in the adult rat brain suggests tight regulation of expression and points toward a distinct functional relevance for each of these GM1 species in neuronal processes.
Vitamin D receptor B1 and exon 1d: functional and evolutionary analysis.
Gardiner, Edith M; Esteban, Luis M; Fong, Colette; Allison, Susan J; Flanagan, Judith L; Kouzmenko, Alexander P; Eisman, John A
2004-05-01
The vitamin D receptor (VDR) shares a conserved structural and functional organization with other nuclear receptor (NR) superfamily members. For many NRs, N-terminal variant isoforms that display distinct cell-, stage- and promoter-specific actions have been identified. The novel VDR isoform VDRB1, with a 50 amino acid N-terminal extension, is produced from low abundance transcripts that contain exon 1d of the human VDR locus. There is evidence for the conservation of this exon in other mammalian and avian species. The transactivation differences between VDRB1 and the original VDR, clarified here, provide insights into mechanisms that may contribute to functional differences and potentially distinct physiological roles for these two VDR isoforms.
Band gaps in periodically magnetized homogeneous anisotropic media
Merzlikin, A. M.; Levy, M.; Vinogradov, A. P.; Wu, Z.; Jalali, A. A.
2010-11-01
In [A. M. Merzlikin, A. P. Vinogradov, A. V. Dorofeenko, M. Inoue, M. Levy, A. B. Granovsky, Physica B 394 (2007) 277] it is shown that in anisotropic magnetophotonic crystal made of anisotropic dielectric layers and isotropic magneto-optical layers the magnetization leads to formation of additional band gaps (BG) inside the Brillouin zones. Due to the weakness of the magneto-optical effects the width of these BG is much smaller than that of usual BG forming on the boundaries of Brillouin zones. In the present communication we show that though the anisotropy suppresses magneto-optical effects. An anisotropic magnetophotonic crystal made of anisotropic dielectric layers and anisotropic magneto-optical; the width of additional BG may be much greater than the width of the usual Brillouin BG. Anisotropy tends to suppress Brillouin zone boundary band gap formation because the anisotropy suppresses magneto-optical properties, while degenerate band gap formation occurs around points of effective isotropy and is not suppressed.
DEFF Research Database (Denmark)
van der Laan, Paul; Sørensen, Niels N.
2017-01-01
A one-dimensional version of EllipSys, labeled as EllipSys1D is presented. Three atmospheric boundary layer test cases are used to show that results of EllipSys1D are exactly the same or very similar as results of EllipSys3D, while EllipSys1D uses 3 to 4 orders of magnitude less CPU hours compared...
Major conformations of the ligand skeleton of a tetranuclear dysprosium (3) tartrate complex
International Nuclear Information System (INIS)
Chevela, V.V.; Semenov, V.Eh.; Bezryadin, S.G.; Savitskaya, T.V.; Kolesar, I.R.; Matveev, S.N.; Shamov, G.A.
1999-01-01
By the molecular mechanics method (MIND program, stoichiometry was studied and basic conformations of ligand frame of dysprosium (3) tetranuclear complex bis-(d-tartrato) bis-(l-tartrato)tetradysprosiate (3) - anion Dy 4 (d-L) 2 (l-L) 2 4- (1) (d-H 4 L = d-tartaric acid, l-H 4 L = l - tartaric acid) were revealed. It is shown that theoretically calculated mP τ constants for so-called compact conformations of 1, where tartratoligands are in gosh conformation, agree with experimentally obtained constant of paramagnetic birefringence (mP e ) of complex 1 [ru
1D to 3D diffusion-reaction kinetics of defects in crystals
DEFF Research Database (Denmark)
Trinkaus, H.; Heinisch, H.L.; Barashev, A.V.
2002-01-01
Microstructural features evolving in crystalline solids from diffusion-reaction kinetics of mobile components depend crucially on the dimension of the underlying diffusion process which is commonly assumed to be three-dimensional (3D). In metals, irradiation-induced displacement cascades produce...... clusters of self-interstitials performing 1D diffusion. Changes between equivalent 1D diffusion paths and transversal diffusion result in diffusion-reaction kinetics between one and three dimensions. An analytical approach suggests a single-variable function (master curve) interpolating between the 1D...
Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism
International Nuclear Information System (INIS)
Halloran, B.P.; Bikle, D.D.; Castro, M.E.; Gee, E.
1989-01-01
Isotope substitution can change the biochemical properties of vitamin D. To determine the effect of substituting 3H for 1H on the metabolism of 1,25(OH)2D3, we measured the metabolic clearance rate and renal metabolism of unlabeled and 3H-labeled 1,25(OH)2D3. Substitution of 3H for 1H on carbons 26 and 27 [1,25(OH)2[26,27(n)-3H]D3] or on carbons 23 and 24 [1,25(OH)2[23,24(n)-3H]D3] reduced the in vivo metabolic clearance rate of 1,25(OH)2D3 by 36% and 37%, respectively, and reduced the in vitro renal catabolism of 1,25(OH)2D3 by 11% and 54%, respectively. Substitutions of 3H for 1H on carbons 23 and 24 as opposed to carbons 26 and 27 reduced conversion of [3H]1,25(OH)2D3 to [3H]1,24,25(OH)2D3 by 25% and to putative 24-oxo-1,23,25-dihydroxyvitamin D3 by 1600%. These results indicate that substitution of 3H for 1H on carbons 26 and 27 or on carbons 23 and 24 can reduce the metabolic clearance rate and in vitro metabolism of 1,25(OH)2D3 and quantitatively alter the pattern of metabolic products produced
Pharmacokinetics of 1,25(OH)(2)D(3) and 1alpha(OH)D(3) in normal and uraemic men
DEFF Research Database (Denmark)
Brandi, Lisbet; Egfjord, Martin; Olgaard, Klaus
2002-01-01
,25(OH)(2)D(3) (n=6) protocol. RESULTS: After oral administration of 1,25(OH)(2)D(3) the bioavailability of 1,25(OH)(2)D(3) was 70.6+/-5.8/72.2+/-4.8% in healthy volunteers/uraemic patients (n.s.). After i.v. administration the volume of distribution of 1,25(OH)(2)D(3) was similar, 0.49+/-0.14 vs 0...
International Nuclear Information System (INIS)
Xin Lingyun; Liu Guangzhen; Wang Liya
2011-01-01
The hydrothermal reactions of Cd, Zn, or Cu(II) acetate salts with H 2 PHDA and BPP flexible ligands afford three new coordination polymers, including [Cd(PHDA)(BPP)(H 2 O)] n (1), [Zn(PHDA)(BPP)] n (2), and [Cu 2 (PHDA) 2 (BPP)] n (3) (H 2 PHDA=1,2-phenylenediacetic acid, BPP=1,3-bis(4-pyridyl)propane). The single-crystal X-ray diffractions reveal that all three complexes feature various metal carboxylate subunits extended further by the BPP ligands to form a diverse range of structures, displaying a remarked structural sensitivity to metal(II) cation. Complex 1 containing PHDA-bridged binuclear cadmium generates 1D double-stranded chain, complex 2 results in 2D→2D interpenetrated (4,4) grids, and complex 3 displays a 3D self-penetrated framework with 4 8 6 6 8 rob topology. In addition, fluorescent analyses show that both 1 and 2 exhibit intense blue-violet photoluminescence in the solid state. - Graphical Abstract: We show diverse supramolecular frameworks based on the same ligands (PHDA and BPP) and different metal acetate salts including 1D double-stranded chain, 2D → 2D twofold interpenetrated layer, and 3D self-penetration networks. Highlights: → Three metal(II = 2 /* ROMAN ) coordination polymers were synthesized using H 2 PHDA and BPP. → The diversity of structures show a remarked sensitivity to metal(II) center. → Complexes show the enhancement of fluorescence compared to that of free ligand.
International Nuclear Information System (INIS)
Wen Lili; Li Yizhi; Dang Dongbin; Tian Zhengfang; Ni Zhaoping; Meng Qingjin
2005-01-01
Two novel interesting d 1 metal coordination polymers, [Zn(H 2 bibzim)(BDC)] n (1) and [Cd(H 2 bibzim)(BDC)] n (2) [H 2 bibzim=2,2'-bibenzimidazole, BDC=1,4-benzenedicarboxylate] have been synthesized under solvothermal conditions and structurally characterized. Both 1 and 2 are constructed from infinite neutral zigzag-like one-dimensional (1D) chains. The π-π interactions and interchain hydrogen-bonding interactions further extend the 1D arrangement to generate a 3D supramolecular architecture for 1 and 2. Both complexes have high thermal stability and display strong blue fluorescent emissions in the solid state upon photo-excitation at 365 nm at room temperature. They are the first two examples that 2,2'-bibenzimidazole has been introduced into the d 1 coordination polymeric framework
Kombinace dvojlomných materiálů pro achromatické fázové destičky
Czech Academy of Sciences Publication Activity Database
Melich, Radek
2011-01-01
Roč. 56, č. 9 (2011), s. 242-244 ISSN 0447-6441 R&D Projects: GA MŠk(CZ) ED2.1.00/03.0079 Institutional research plan: CEZ:AV0Z20430508 Keywords : Phasic wafers * achromatic wafers * birefringent materials Subject RIV: BH - Optics, Masers, Lasers
Apyan, A; Badelek, B; Ballestrero, S; Biino, C; Birol, I; Cenci, P; Connell, S H; Eichblatt, S; Fonseca, T; Freund, A; Gorini, B; Groess, R; Ispirian, K; Ketel, T; Kononets, Y V; López, A; Mangiarotti, A; Sellschop, J P Friedel; Shieh, M; Sona, P; Strakhovenko, V M; Uggerhøj, U; Uggerhøj, Erik; Van Rens, B; Velasco, M; Vilakazi, Z Z; Wessely, O; Ünel, G; Kononets, Yu V
2008-01-01
The processes of coherent bremsstrahlung (CB) and coherent pair production (CPP) based on aligned crystal targets have been studied in the energy range 20-170 GeV. The experimental arrangement allowed these phenomena as well as their polarization dependence to be evaluated under conditions where single-photon cross-sections could be measured. This proved very important as the theoretical description of CB and CPP is an area of active theoretical debate and development. The theoretical approach used in this paper predicts both the cross sections and polarization observables very well for the experimental conditions investigated, indicating that the understanding of CB and CPP is reliable up to energies of 170 GeV. A birefringence effect in CPP was studied and it was demonstrated this enabled new technologies for high energy photon beam optics, such as polarimeters (for both linear and circular polarization) and phase plates. We also present new results regarding the features of coherent high energy photon emis...
Wu, E Y S; Ade, P; Bock, J; Bowden, M; Brown, M L; Cahill, G; Castro, P G; Church, S; Culverhouse, T; Friedman, R B; Ganga, K; Gear, W K; Gupta, S; Hinderks, J; Kovac, J; Lange, A E; Leitch, E; Melhuish, S J; Memari, Y; Murphy, J A; Orlando, A; Piccirillo, L; Pryke, C; Rajguru, N; Rusholme, B; Schwarz, R; O'Sullivan, C; Taylor, A N; Thompson, K L; Turner, A H; Zemcov, M
2009-04-24
We constrain parity-violating interactions to the surface of last scattering using spectra from the QUaD experiment's second and third seasons of observations by searching for a possible systematic rotation of the polarization directions of cosmic microwave background photons. We measure the rotation angle due to such a possible "cosmological birefringence" to be 0.55 degrees +/-0.82 degrees (random) +/-0.5 degrees (systematic) using QUaD's 100 and 150 GHz temperature-curl and gradient-curl spectra over the spectra over the multipole range 200
Development of a 3D consistent 1D neutronics model for reactor core simulation
International Nuclear Information System (INIS)
Lee, Ki Bog; Joo, Han Gyu; Cho, Byung Oh; Zee, Sung Quun
2001-02-01
In this report a 3D consistent 1D model based on nonlinear analytic nodal method is developed to reproduce the 3D results. During the derivation, the current conservation factor (CCF) is introduced which guarantees the same axial neutron currents obtained from the 1D equation as the 3D reference values. Furthermore in order to properly use 1D group constants, a new 1D group constants representation scheme employing tables for the fuel temperature, moderator density and boron concentration is developed and functionalized for the control rod tip position. To test the 1D kinetics model with CCF, several steady state and transient calculations were performed and compared with 3D reference values. The errors of K-eff values were reduced about one tenth when using CCF without significant computational overhead. And the errors of power distribution were decreased to the range of one fifth or tenth at steady state calculation. The 1D kinetics model with CCF and the 1D group constant functionalization employing tables as a function of control rod tip position can provide preciser results at the steady state and transient calculation. Thus it is expected that the 1D kinetics model derived in this report can be used in the safety analysis, reactor real time simulation coupled with system analysis code, operator support system etc.
Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.
Vichaiwong, Kanokwan; Purohit, Suneet; An, Ding; Toyoda, Taro; Jessen, Niels; Hirshman, Michael F; Goodyear, Laurie J
2010-10-15
TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab-GAP (GTPase-activating protein) that is highly expressed in skeletal muscle, but little is known about TBC1D1 regulation and function. We studied TBC1D1 phosphorylation on three predicted AMPK (AMP-activated protein kinase) phosphorylation sites (Ser231, Ser660 and Ser700) and one predicted Akt phosphorylation site (Thr590) in control mice, AMPKα2 inactive transgenic mice (AMPKα2i TG) and Akt2-knockout mice (Akt2 KO). Muscle contraction significantly increased TBC1D1 phosphorylation on Ser231 and Ser660, tended to increase Ser700 phosphorylation, but had no effect on Thr590. AICAR (5-aminoimidazole-4-carboxyamide ribonucleoside) also increased phosphorylation on Ser231, Ser660 and Ser700, but not Thr590, whereas insulin only increased Thr590 phosphorylation. Basal and contraction-stimulated TBC1D1 Ser231, Ser660 and Ser700 phosphorylation were greatly reduced in AMPKα2i TG mice, although contraction still elicited a small increase in phosphorylation. Akt2 KO mice had blunted insulin-stimulated TBC1D1 Thr590 phosphorylation. Contraction-stimulated TBC1D1 Ser231 and Ser660 phosphorylation were normal in high-fat-fed mice. Glucose uptake in vivo was significantly decreased in tibialis anterior muscles overexpressing TBC1D1 mutated on four predicted AMPK phosphorylation sites. In conclusion, contraction causes site-specific phosphorylation of TBC1D1 in skeletal muscle, and TBC1D1 phosphorylation on AMPK sites regulates contraction-stimulated glucose uptake. AMPK and Akt regulate TBC1D1 phosphorylation, but there must be additional upstream kinases that mediate TBC1D1 phosphorylation in skeletal muscle.
Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers
Navarro, Gemma; Moreno, Estefania; Bonaventura, Jordi; Brugarolas, Marc; Farré, Daniel; Aguinaga, David; Mallol, Josefa; Cortés, Antoni; Casadó, Vicent; Lluís, Carmen; Ferre, Sergi
2013-01-01
Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine receptors. Cocaine is able to subvert these balanced inputs by altering the cell signaling of these two pathways such that D1 reward seeking pathway dominates. Here, we provide an explanation at the cellular and biochemical level how cocaine may achieve this. Exploring the effect of cocaine on dopamine D2 receptors function, we present evidence of σ1 receptor molecular and functional interaction with dopamine D2 receptors. Using biophysical, biochemical, and cell biology approaches, we discovered that D2 receptors (the long isoform of the D2 receptor) can complex with σ1 receptors, a result that is specific to D2 receptors, as D3 and D4 receptors did not form heteromers. We demonstrate that the σ1-D2 receptor heteromers consist of higher order oligomers, are found in mouse striatum and that cocaine, by binding to σ1 -D2 receptor heteromers, inhibits downstream signaling in both cultured cells and in mouse striatum. In contrast, in striatum from σ1 knockout animals these complexes are not found and this inhibition is not seen. Taken together, these data illuminate the mechanism by which the initial exposure to cocaine can inhibit signaling via D2 receptor containing neurons, destabilizing the delicate signaling balance influencing drug seeking that emanates from the D1 and D2 receptor containing neurons in the brain. PMID:23637801
Styrylpyrylium Salts: 1H and 13C NMR High-Resolution Spectroscopy (1D and 2D
Directory of Open Access Journals (Sweden)
Jean Claude W. Ouédraogo
2010-01-01
Full Text Available 1H and 13C NMR high-resolution spectroscopy (1D and 2D (1H, 1H-COSY, HSQC, HMBC for four styrylpyrylium perchlorates were carried out and signal attributions are reported. Chemical shifts observed on 13C NMR spectra for the styrylpyrylium salts were compared with net atomic charge for carbon obtained by AM1 semiempirical calculations. The position of the styryl group present low effect on chemical shifts for carbon atoms, while the presence of methyl group led to the unshielding of the substituted carbon.
The vitamin D analogue ED71 but Not 1,25(OH2D3 targets HIF1α protein in osteoclasts.
Directory of Open Access Journals (Sweden)
Yuiko Sato
Full Text Available Although both an active form of the vitamin D metabolite, 1,25(OH2D3, and the vitamin D analogue, ED71 have been used to treat osteoporosis, anti-bone resorbing activity is reportedly seen only in ED71- but not in 1,25(OH2D3 -treated patients. In addition, how ED71 inhibits osteoclast activity in patients has not been fully characterized. Recently, HIF1α expression in osteoclasts was demonstrated to be required for development of post-menopausal osteoporosis. Here we show that ED71 but not 1,25(OH2D3, suppress HIF1α protein expression in osteoclasts in vitro. We found that 1,25(OH2D3 or ED71 function in osteoclasts requires the vitamin D receptor (VDR. ED71 was significantly less effective in inhibiting M-CSF and RANKL-stimulated osteoclastogenesis than was 1,25(OH2D3 in vitro. Downregulation of c-Fos protein and induction of Ifnβ mRNA in osteoclasts, both of which reportedly block osteoclastogenesis induced by 1,25(OH2D3 in vitro, were both significantly higher following treatment with 1,25(OH2D3 than with ED71. Thus, suppression of HIF1α protein activity in osteoclasts in vitro, which is more efficiently achieved by ED71 rather than by 1,25(OH2D3, could be a reliable read-out in either developing or screening reagents targeting osteoporosis.
Directory of Open Access Journals (Sweden)
Noirez Laurence
2017-03-01
Full Text Available This work points out the importance of the substrate boundary conditions to lower the dissipation in the dynamic measurement and access the closest dynamic characteristics of liquids, in particular to access the low frequency shear elasticity. The liquid/surface interface is a source of dissipation that enters and impacts the measurement. Examples of steady-state shear flows or flow birefringence are presented to highlight the non-universality of the behavior with respect to the nature of the substrate or the sheared thickness. Additionally the present development completes and extends the identification of low frequency shear elasticity made at sub-millimeter gaps in various one-component liquids to salt-free aqueous solutions (CTAB-water (Hexadecyl-TrimethylAmmonium Bromide.
Ds1*(2860) and Ds3*(2860): candidates for 1D charmed-strange mesons
International Nuclear Information System (INIS)
Song, Qin-Tao; Chen, Dian-Yong; Liu, Xiang; Matsuki, Takayuki
2015-01-01
Newly observed two charmed-strange resonances, D s1 * (2860) and D s3 * (2860), are investigated by calculating their Okubo-Zweig-Iizuka-allowed strong decays, which shows that they are suitable candidates for the 1 3 D 1 and 1 3 D 3 states in the charmed-strange meson family. Our study also predicts other main decay modes of D s1 * (2860) and D s3 * (2860), which can be accessible at the future experiment. In addition, the decay behaviors of the spin partners of D s1 * (2860) and D s3 * (2860), i.e., 1D(2 - ) and 1D'(2 - ), are predicted in this work, which are still missing at present. The experimental search for the missing 1D(2 - ) and 1D'(2 - ) charmed-strange mesons is an intriguing and challenging task for further experiments. (orig.)
The D1 parameter for the equatorial F1 region
International Nuclear Information System (INIS)
Adeniyi, J.O.; Radicella, S.M.
2002-01-01
This work is a contribution to the effort at improving the representation of the F1 equatorial ionospheric region in the International Reference Ionosphere (IRI) model. The D1 parameter has been proposed for describing the F1 layer. We have therefore produced a maiden table of D1 parameter for an equatorial station. Diurnal and seasonal effects were considered. (author)
Optical activity via Kerr nonlinearity in a spinning chiral medium
Energy Technology Data Exchange (ETDEWEB)
Khan, Anwar Ali, E-mail: anwarali@uom.edu.pk [Department of Physics, University of Malakand at Chakdara Dir(L) (Pakistan); Bacha, Bakht Amin, E-mail: aminoptics@gmail.com [Department of Physics, University of Malakand at Chakdara Dir(L) (Pakistan); Khan, Rahmat Ali, E-mail: rahmat_alipk@yahoo.com [Department of Mathematics, University of Malakand (Pakistan)
2016-11-11
Optical activity is investigated in a chiral medium by employing the four level cascade atomic model, in which the optical responses of the atomic medium are studied with Kerr nonlinearity. Light entering into a chiral medium splits into circular birefringent beams. The angle of divergence between the circular birefringent beams and the polarization states of the two light beams is manipulated with Kerr nonlinearity. In the stationary chiral medium the angle of divergence between the circular birefringent beams is calculated to be 1.3 radian. Furthermore, circular birefringence is optically controlled in a spinning chiral medium, where the maximum rotary photon drag angle for left (right) circularly polarized beam is ±1.1 (±1.5) microradian. The change in the angle of divergence between circular birefringent beams by rotary photon drag is calculated to be 0.4 microradian. The numerical results may help to understand image designing, image coding, discovery of photonic crystals and optical sensing technology. - Highlights: • Coherent control of a circular birefringence in a chiral medium is studied. • Angle of divergence between birefringent beams is modified with Kerr nonlinearity. • Rotary photon drag is controlled for birefringent beams and enhanced with Kerr nonlinearity in a spinning medium. • Rotation of the angle of divergence is observed with mechanical rotation of the medium about an axis and modified with Kerr effect. • A change in the angle of divergence is calculated by about a microradian with rotary photon drag.
TBC1D24 genotype–phenotype correlation
Balestrini, Simona; Milh, Mathieu; Castiglioni, Claudia; Lüthy, Kevin; Finelli, Mattea J.; Verstreken, Patrik; Cardon, Aaron; Stražišar, Barbara Gnidovec; Holder, J. Lloyd; Lesca, Gaetan; Mancardi, Maria M.; Poulat, Anne L.; Repetto, Gabriela M.; Banka, Siddharth; Bilo, Leonilda; Birkeland, Laura E.; Bosch, Friedrich; Brockmann, Knut; Cross, J. Helen; Doummar, Diane; Félix, Temis M.; Giuliano, Fabienne; Hori, Mutsuki; Hüning, Irina; Kayserili, Hulia; Kini, Usha; Lees, Melissa M.; Meenakshi, Girish; Mewasingh, Leena; Pagnamenta, Alistair T.; Peluso, Silvio; Mey, Antje; Rice, Gregory M.; Rosenfeld, Jill A.; Taylor, Jenny C.; Troester, Matthew M.; Stanley, Christine M.; Ville, Dorothee; Walkiewicz, Magdalena; Falace, Antonio; Fassio, Anna; Lemke, Johannes R.; Biskup, Saskia; Tardif, Jessica; Ajeawung, Norbert F.; Tolun, Aslihan; Corbett, Mark; Gecz, Jozef; Afawi, Zaid; Howell, Katherine B.; Oliver, Karen L.; Berkovic, Samuel F.; Scheffer, Ingrid E.; de Falco, Fabrizio A.; Oliver, Peter L.; Striano, Pasquale; Zara, Federico
2016-01-01
Objective: To evaluate the phenotypic spectrum associated with mutations in TBC1D24. Methods: We acquired new clinical, EEG, and neuroimaging data of 11 previously unreported and 37 published patients. TBC1D24 mutations, identified through various sequencing methods, can be found online (http://lovd.nl/TBC1D24). Results: Forty-eight patients were included (28 men, 20 women, average age 21 years) from 30 independent families. Eighteen patients (38%) had myoclonic epilepsies. The other patients carried diagnoses of focal (25%), multifocal (2%), generalized (4%), and unclassified epilepsy (6%), and early-onset epileptic encephalopathy (25%). Most patients had drug-resistant epilepsy. We detail EEG, neuroimaging, developmental, and cognitive features, treatment responsiveness, and physical examination. In silico evaluation revealed 7 different highly conserved motifs, with the most common pathogenic mutation located in the first. Neuronal outgrowth assays showed that some TBC1D24 mutations, associated with the most severe TBC1D24-associated disorders, are not necessarily the most disruptive to this gene function. Conclusions: TBC1D24-related epilepsy syndromes show marked phenotypic pleiotropy, with multisystem involvement and severity spectrum ranging from isolated deafness (not studied here), benign myoclonic epilepsy restricted to childhood with complete seizure control and normal intellect, to early-onset epileptic encephalopathy with severe developmental delay and early death. There is no distinct correlation with mutation type or location yet, but patterns are emerging. Given the phenotypic breadth observed, TBC1D24 mutation screening is indicated in a wide variety of epilepsies. A TBC1D24 consortium was formed to develop further research on this gene and its associated phenotypes. PMID:27281533
Partial breaking of N = 1, D = 10 supersymmetry
International Nuclear Information System (INIS)
Bellucci, S.
1999-01-01
In this paper is described the spontaneous partial breaking of N =1, D =10 supersymmetry to N = (1, 0), d = 6 and its dimensionally-reduced versions in the framework of nonlinear realizations. The basic Goldstone superfield is N = (1, 0), d = 6 hyper multiplet superfield satisfying a nonlinear generalization of the standard hyper multiplet constraint. It is here interpreted the generalized constraint as the manifestly world volume supersymmetric form of equations of motion of the type 1 super 5-brane in D 10. The related issues here addressed are a possible existence of brane extension of off-shell hyper multiplet actions, the possibility to utilize vector N = (1, 0), d =6 supermultiplet as the Goldstone one, and the description of 1/4 breaking of N =1, D = 11 supersymmetry
Dopamine D/sub 2/ and D/sub 1/ receptors: biochemical characterization
Energy Technology Data Exchange (ETDEWEB)
Niznik, H B
1986-01-01
In order to label dopamine D/sub 2/ receptors reversibly and selectively the potent substituted benzamide neuroleptic, YM-09151-2, was tritium labeled and its binding characteristics to striatal homogenates investigated. (/sup 3/H) YM-09151-2 bound to D/sub 2/ receptors with high affinity in a specific, saturable, reversible and sodium dependent fashion, displaying an appropriate pharmacological D/sub 2/ receptor profile. (/sup 3/H) YM-09151-2 appears to be the ligand of choice for labeling D/sub 2/ receptors since it displays approximately 20-fold lower affinity for serotonergic S/sub 2/ receptors than does (/sup 3/H) spiperone. As an initial step towards the molecular identification of the ligand binding subunit of the striatal D/sub 2/ receptor, photolabile analogues of the substituted benzamide clebopride were synthesized and their reversible and irreversible binding interactions to D/sub 2/ receptors characterized. D/sub 2/ receptor photoinactivation was prevented in a concentration and stereoselective manner by dopaminergic agonists and antagonists. In vivo biodistribution studies with (/sup 125/I) iodoazidoclebopride confirmed the ligand's ability to bind to D/sub 2/ receptor-rich regions and as such, may become a useful tool for the molecular characterization of D/sub 2/ receptor proteins. Digitonin solubilized striatal dopamine D/sub 2/ and D/sub 1/ receptors can be completely separated with full retention of biological activity by steric exclusion High Pressure Liquid Chromatography (HPLC) with corresponding Stokes radii of 7.1 and 5.6 nm.
Nested 1D-2D approach for urban surface flood modeling
Murla, Damian; Willems, Patrick
2015-04-01
Floods in urban areas as a consequence of sewer capacity exceedance receive increased attention because of trends in urbanization (increased population density and impermeability of the surface) and climate change. Despite the strong recent developments in numerical modeling of water systems, urban surface flood modeling is still a major challenge. Whereas very advanced and accurate flood modeling systems are in place and operation by many river authorities in support of flood management along rivers, this is not yet the case in urban water management. Reasons include the small scale of the urban inundation processes, the need to have very high resolution topographical information available, and the huge computational demands. Urban drainage related inundation modeling requires a 1D full hydrodynamic model of the sewer network to be coupled with a 2D surface flood model. To reduce the computational times, 0D (flood cones), 1D/quasi-2D surface flood modeling approaches have been developed and applied in some case studies. In this research, a nested 1D/2D hydraulic model has been developed for an urban catchment at the city of Gent (Belgium), linking the underground sewer (minor system) with the overland surface (major system). For the overland surface flood modelling, comparison was made of 0D, 1D/quasi-2D and full 2D approaches. The approaches are advanced by considering nested 1D-2D approaches, including infiltration in the green city areas, and allowing the effects of surface storm water storage to be simulated. An optimal nested combination of three different mesh resolutions was identified; based on a compromise between precision and simulation time for further real-time flood forecasting, warning and control applications. Main streets as mesh zones together with buildings as void regions constitute one of these mesh resolution (3.75m2 - 15m2); they have been included since they channel most of the flood water from the manholes and they improve the accuracy of
T-duality of Green-Schwarz superstrings on AdS_d×S"d×M"1"0"−"2"d
International Nuclear Information System (INIS)
Abbott, Michael C.; Murugan, Jeff; Penati, Silvia; Pittelli, Antonio; Sorokin, Dmitri; Sundin, Per; Tarrant, Justine; Wolf, Martin; Wulff, Linus
2015-01-01
We verify the self-duality of Green-Schwarz supercoset sigma models on AdS_d×S"d backgrounds (d=2,3,5) under combined bosonic and fermionic T-dualities without gauge fixing kappa symmetry. We also prove this property for superstrings on AdS_d×S"d×S"d(d=2,3) described by supercoset sigma models with the isometries governed by the exceptional Lie supergroups D(2,1;α) (d=2) and D(2,1;α)×D(2,1;α) (d=3), which requires an additional T-dualisation along one of the spheres. Then, by taking into account the contribution of non-supercoset fermionic modes (up to the second order), we provide evidence for the T-self-duality of the complete type IIA and IIB Green-Schwarz superstring theory on AdS_d×S"d×T"1"0"−"2"d (d=2,3) backgrounds with Ramond-Ramond fluxes. Finally, applying the Buscher-like rules to T-dualising supergravity fields, we prove the T-self-duality of the whole class of the AdS_d×S"d×M"1"0"−"2"d superbackgrounds with Ramond-Ramond fluxes in the context of supergravity.
Birefringence Bragg Binary (3B) grating, quasi-Bragg grating and immersion gratings
Ebizuka, Noboru; Morita, Shin-ya; Yamagata, Yutaka; Sasaki, Minoru; Bianco, Andorea; Tanabe, Ayano; Hashimoto, Nobuyuki; Hirahara, Yasuhiro; Aoki, Wako
2014-07-01
A volume phase holographic (VPH) grating achieves high angular dispersion and very high diffraction efficiency for the first diffraction order and for S or P polarization. However the VPH grating could not achieve high diffraction efficiency for non-polarized light at a large diffraction angle because properties of diffraction efficiencies for S and P polarizations are different. Furthermore diffraction efficiency of the VPH grating extinguishes toward a higher diffraction order. A birefringence binary Bragg (3B) grating is a thick transmission grating with optically anisotropic material such as lithium niobate or liquid crystal. The 3B grating achieves diffraction efficiency up to 100% for non-polarized light by tuning of refractive indices for S and P polarizations, even in higher diffraction orders. We fabricated 3B grating with liquid crystal and evaluated the performance of the liquid crystal grating. A quasi-Bragg (QB) grating, which consists long rectangle mirrors aligned in parallel precisely such as a window shade, also achieves high diffraction efficiency toward higher orders. We fabricated QB grating by laminating of silica glass substrates and glued by pressure fusion of gold films. A quasi-Bragg immersion (QBI) grating has smooth mirror hypotenuse and reflector array inside the hypotenuse, instead of step-like grooves of a conventional immersion grating. An incident beam of the QBI grating reflects obliquely at a reflector, then reflects vertically at the mirror surface and reflects again at the same reflector. We are going to fabricate QBI gratings by laminating of mirror plates as similar to fabrication of the QB grating. We will also fabricate silicon and germanium immersion gratings with conventional step-like grooves by means of the latest diamond machining methods. We introduce characteristics and performance of these gratings.
26 CFR 1.1503(d)-0 - Table of contents.
2010-04-01
... section lists the captions contained in §§ 1.1503(d)-1 through 1.1503(d)-8. § 1.1503(d)-1Definitions and... of a dual consolidated loss used in other taxable years. (5) Reconstituted net operating losses. (d...) Foreign currency gain or loss recognized under section 987. (vi) Recapture of dual consolidated loss. (d...
BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells
International Nuclear Information System (INIS)
Nakuci, Enkeleda; Mahner, Sven; DiRenzo, James; ElShamy, Wael M.
2006-01-01
The regulator of cell cycle progression, cyclin D1, is up-regulated in breast cancer cells; its expression is, in part, dependent on ERα signaling. However, many ERα-negative tumors and tumor cell lines (e.g., SKBR3) also show over-expression of cyclin D1. This suggests that, in addition to ERα signaling, cyclin D1 expression is under the control of other signaling pathways; these pathways may even be over-expressed in the ERα-negative cells. We previously noticed that both ERα-positive and -negative cell lines over-express BRCA1-IRIS mRNA and protein. Furthermore, the level of over-expression of BRCA1-IRIS in ERα-negative cell lines even exceeded its over-expression level in ERα-positive cell lines. In this study, we show that: (1) BRCA1-IRIS forms complex with two of the nuclear receptor co-activators, namely, SRC1 and SRC3 (AIB1) in an ERα-independent manner. (2) BRCA1-IRIS alone, or in connection with co-activators, is recruited to the cyclin D1 promoter through its binding to c-Jun/AP1 complex; this binding activates the cyclin D1 expression. (3) Over-expression of BRCA1-IRIS in breast cells over-activates JNK/c-Jun; this leads to the induction of cyclin D1 expression and cellular proliferation. (4) BRCA1-IRIS activation of JNK/c-Jun/AP1 appears to account for this, because in cells that were depleted from BRCA1-IRIS, JNK remained inactive. However, depletion of SRC1 or SRC3 instead reduced c-Jun expression. Our data suggest that this novel signaling pathway links BRCA1-IRIS to cellular proliferation through c-Jun/AP1 nuclear pathway; finally, this culminates in the increased expression of the cyclin D1 gene
Development of specific dopamine D-1 agonists and antagonists
International Nuclear Information System (INIS)
Sakolchai, S.
1987-01-01
To develop potentially selective dopamine D-1 agonists and to investigate on the structural requirement for D-1 activity, the derivatives of dibenzocycloheptadiene are synthesized and pharmacologically evaluated. The target compounds are 5-aminomethyl-10,11-dihydro-1,2-dihydroxy-5H-dibenzo[a,d]cycloheptene hydrobromide 10 and 9,10-dihydroxy-1,2,3,7,8,12b-hexahydrobenzo[1,2]cyclohepta[3,4,5d,e]isoquinoline hydrobromide 11. In a dopamine-sensitive rat retinal adenylate cyclase assay, a model for D-1 activity, compound 10 is essentially inert for both agonist and antagonist activity. In contrast, compound 11 is approximately equipotent to dopamine in activation of the D-1 receptor. Based on radioligand and binding data, IC 50 of compound 11 for displacement of 3 H-SCH 23390, a D-1 ligand, is about 7 fold less than that for displacement of 3 H-spiperone, a D-2 ligand. These data indicate that compound 11 is a potent selective dopamine D-1 agonist. This study provides a new structural class of dopamine D-1 acting agent: dihydroxy-benzocycloheptadiene analog which can serve as a lead compound for further drug development and as a probe for investigation on the nature of dopamine D-1 receptor
Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia.
Farré, Daniel; Muñoz, Ana; Moreno, Estefanía; Reyes-Resina, Irene; Canet-Pons, Júlia; Dopeso-Reyes, Iria G; Rico, Alberto J; Lluís, Carme; Mallol, Josefa; Navarro, Gemma; Canela, Enric I; Cortés, Antonio; Labandeira-García, José L; Casadó, Vicent; Lanciego, José L; Franco, Rafael
2015-12-01
Radioligand binding assays to rat striatal dopamine D1 receptors showed that brain lateralization of the dopaminergic system were not due to changes in expression but in agonist affinity. D1 receptor-mediated striatal imbalance resulted from a significantly higher agonist affinity in the left striatum. D1 receptors heteromerize with dopamine D3 receptors, which are considered therapeutic targets for dyskinesia in parkinsonian patients. Expression of both D3 and D1-D3 receptor heteromers were increased in samples from 6-hydroxy-dopamine-hemilesioned rats rendered dyskinetic by treatment with 3, 4-dihydroxyphenyl-L-alanine (L-DOPA). Similar findings were obtained using striatal samples from primates. Radioligand binding studies in the presence of a D3 agonist led in dyskinetic, but not in lesioned or L-DOPA-treated rats, to a higher dopamine sensitivity. Upon D3-receptor activation, the affinity of agonists for binding to the right striatal D1 receptor increased. Excess dopamine coming from L-DOPA medication likely activates D3 receptors thus making right and left striatal D1 receptors equally responsive to dopamine. These results show that dyskinesia occurs concurrently with a right/left striatal balance in D1 receptor-mediated neurotransmission.
Reconstruction of 3d grain boundaries from rock thin sections, using polarised light
Markus Hammes, Daniel; Peternell, Mark
2016-04-01
Grain boundaries affect the physical and chemical properties of polycrystalline materials significantly by initiating reactions and collecting impurities (Birchenall, 1959), and play an essential role in recrystallization (Doherty et al. 1997). In particular, the shape and crystallographic orientation of grain boundaries reveal the deformation and annealing history of rocks (Kruhl and Peternell 2002, Kuntcheva et al. 2006). However, there is a lack of non-destructive and easy-to-use computer supported methods to determine grain boundary geometries in 3D. The only available instrument using optical light to measure grain boundary angles is still the polarising microscope with attached universal stage; operated manually and time-consuming in use. Here we present a new approach to determine 3d grain boundary orientations from 2D rock thin sections. The data is recorded by using an automatic fabric analyser microscope (Peternell et al., 2010). Due to its unique arrangement of 9 light directions the highest birefringence colour due to each light direction and crystal orientation (retardation) can be determined at each pixel in the field of view. Retardation profiles across grain boundaries enable the calculation of grain boundary angle and direction. The data for all positions separating the grains are combined and further processed. In combination with the lateral position of the grain boundary, acquired using the FAME software (Hammes and Peternell, in review), the data is used to reconstruct a 3d grain boundary model. The processing of data is almost fully automatic by using MATLAB®. Only minor manual input is required. The applicability was demonstrated on quartzite samples, but the method is not solely restricted on quartz grains and other birefringent polycrystalline materials could be used instead. References: Birchenall, C.E., 1959: Physical Metallurgy. McGraw-Hill, New York. Doherty, R.D., Hughes, D.A., Humphreys, F.J., Jonas, J.J., Juul Jensen, D., Kassner, M
Infrared and swelling study of the hydration-induced phase transition of wet-spun hyaluronate films
Hoppe, A. D.; Marlowe, R. L.; Lee, S. A.; Powell, J. W.; Rupprecht, A.
1997-03-01
The hydration properties of wet-spun films of hyaluronate (HA) with four different counterions (Li^+, Cs^+, Mg^2+, and Ca^2+) have been studied using optical microscopy, optical birefringence and infrared (IR) spectroscopy. Small pieces of these films were found to be optically birefringent up to hydration levels near 90 % relative humidity (RH). All four kinds of films then became optically isotropic and display dramatic changes in size. These changes are consistent with the occurrence of an order-disorder (o-d) transition. IR spectroscopy of the backbone region (from 800 to 1000 cm-1) suggests that the Li^+, Cs^+ and Ca^2+ films are very similar. Two IR bands in this region are observed at low RH and show no dependence on hydration until the o-d transition. The IR spectra of CaHA show five bands in this region. These five bands are observed to 95 % RH.
Shape-Control of a 0D/1D NaFe0.9Mn0.1PO4 Nano-Complex by Electrospinning
Shin, Mi-Ra; Son, Jong-Tae
2018-03-01
NaFePO4 with a maricite structure was one of the most promising candidates for sodium ion batteries (SIBs) due to its advantages of environmental friendly and having low cost. However, it has low electrochemical conductivity and energy density, which impose limitations on its application as commercial cathode materials. In this study, other transition-metal ions such as Mn2+ were substituted into the iron (Fe2+) site in NaFePO4 to increase the surface area and the number of nanofibers in the prepared one-dimensional (1D) nano-sized material with 0D/1D dimensions to enhance the energy density. Also, the 0D/1D NaFe0.9Mn0.1PO4 cathode material has increased electrochemical conductivity because the fiber size was reduced to the nano-scale level by using the electrospinning method in order to decrease the diffusion path of Na-ions. The morphology of the 0D/1D nanofiber was evaluated by Field-emission scanning electron microscope and atomic force microscope analyses. The NaFe0.9Mn0.1PO4 nanofibers had a diameter of approximately 180 nm, while the spherical particle had a diameter 1 μm. The 0D/1D nano-sized cathode material show a discharge capacity of 27 mAhg -1 at a 0.05 C rate within the 2.0 4.5 V voltage range and a low R ct of 110 Ω.
International Nuclear Information System (INIS)
Reinhardt, T.A.; Horst, R.L.
1986-01-01
The authors examined the effect of 1,25-(OH) 2 D 3 on receptor concentration in cultured cells (T-47D). Two days prior to experiment, cells were fed with RPMI 1640 + 10% serum and 24-32 hours prior to experiment the media was replaced with RPMI 1640 + 25 mM Hepes + 1% serum. [ 3 H]-1,25-(OH) 2 D 3 +/- 100-fold molar excess cold hormone was used to treat the cells. Occupied receptors were measured in freshly prepared cytosols. Total receptors were measured following a 16-hour incubation of cytosols in the presence of 0.6 nM [ 3 H]-1,25-(OH) 2 D 3 +/- 100-fold molar excess of cold hormone at 4 0 C. Treatment of cell cultures for 16-18 hours with 0.5-1.0 nM [ 3 H]-1,25-(OH) 2 D 3 resulted in a 30-40% receptor occupancy by the hormone and a 2- to 3-fold increase in total cell receptor as compared to vehicle-treated controls. Time course studies showed a rapid increase in total receptors up to 16 hours post-treatment in the face of declining receptor occupancy. Actinomycin D blocked the [ 3 H]-1,25-(OH) 2 D 3 -dependent rise in cell receptor. The physiological significance of this receptor upregulation is not known nor is it known whether upregulation results from synthesis of new receptors and/or is the result of the activation of preformed receptors by a inducible activator protein
26 CFR 1.411(d)-1 - Coordination of vesting and discrimination requirements. [Reserved
2010-04-01
... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Coordination of vesting and discrimination requirements. [Reserved] 1.411(d)-1 Section 1.411(d)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF... Plans, Etc. § 1.411(d)-1 Coordination of vesting and discrimination requirements. [Reserved] ...
DEFF Research Database (Denmark)
Treebak, Jonas Thue; Pehmøller, Christian; Kristensen, Jonas Møller
2014-01-01
We investigated the phosphorylation signatures of two Rab GTPase activating proteins TBC1D1 and TBC1D4 in human skeletal muscle in response to physical exercise and physiological insulin levels induced by a carbohydrate rich meal using a paired experimental design. Eight healthy male volunteers e...
Imaging of THz waves in 2D photonic crystal structures embedded in a slab waveguide
International Nuclear Information System (INIS)
Peier, P; Merbold, H; Feurer, T; Pahinin, V; Nelson, K A
2010-01-01
We present space- and time-resolved simulations and measurements of single-cycle terahertz (THz) waves propagating through two-dimensional (2D) photonic crystal structures embedded in a slab waveguide. Specifically, we use a plane wave expansion technique to calculate the band structure and a time-dependent finite-element method to simulate the temporal evolution of the THz waves. Experimentally, we measure the space-time evolution of the THz waves through a coherent time-resolved imaging method. Three different structures are laser machined in LiNbO 3 crystal slabs and analyzing the transmitted as well as the reflected THz waveforms allows determination of the bandgaps. Comparing the results with the calculated band diagrams and the time-dependent simulations shows that the experiments are consistent with 3D simulations, which include the slab waveguide geometry, the birefringence of the material, and a careful analysis of the excited modes within the band diagrams.
Production of the excited charm mesons D{sub 1} and D{sup *}{sub 2} at HERA
Energy Technology Data Exchange (ETDEWEB)
Verbytskyi, Andrii
2013-02-15
The production of the excited charm mesons D{sub 1}, D{sup *}{sub 2} and D{sup +}{sub s1} in ep collisions has been measured with the ZEUS detector at Hera. The data sample taken by the ZEUS detector in the years 2003-2007, corresponding to an integrated luminosity of 373 pb{sup -1} has been used. The masses of the neutral, charged and strange states, the widths of the neutral states, the helicity parameters of D{sup 0}{sub 1} and D{sup +}{sub s1} were determined and compared with other measurements and with theoretical expectations. The measured helicity parameters of the D{sup 0}{sub 1} and D{sup +}{sub s1} allows for some mixing of S- and D-waves in their decays to D{sup *{+-}}{pi}{sup -+} and D{sup *{+-}}K{sup 0} respectively. The measured value of the D{sup 0}{sub 1} helicity parameter is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D{sup *0}{sub 2}, D{sup *{+-}}{sub 2} and D{sup +}{sub s1} states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D{sub 1}, D{sup *}{sub 2} and D{sup +}{sub s1} were measured and are consistent with those obtained in e{sup +}e{sup -} annihilations. The Grid computing technology has a high importance for modern High Energy Physics. This technology has been successfully used in Zeus experiment for the MC simulations and data analysis. The dedicated infrastructure has been maintained by the author since 2010. In addition to continuous support, the author has upgraded and improved the performance of the Grid MC simulations and contributed to the Zeus data preservation project.
Stability and accuracy of 3D neutron transport simulations using the 2D/1D method in MPACT
International Nuclear Information System (INIS)
Collins, Benjamin; Stimpson, Shane; Kelley, Blake W.; Young, Mitchell T.H.; Kochunas, Brendan; Graham, Aaron; Larsen, Edward W.; Downar, Thomas; Godfrey, Andrew
2016-01-01
A consistent “2D/1D” neutron transport method is derived from the 3D Boltzmann transport equation, to calculate fuel-pin-resolved neutron fluxes for realistic full-core Pressurized Water Reactor (PWR) problems. The 2D/1D method employs the Method of Characteristics to discretize the radial variables and a lower order transport solution to discretize the axial variable. This paper describes the theory of the 2D/1D method and its implementation in the MPACT code, which has become the whole-core deterministic neutron transport solver for the Consortium for Advanced Simulations of Light Water Reactors (CASL) core simulator VERA-CS. Several applications have been performed on both leadership-class and industry-class computing clusters. Results are presented for whole-core solutions of the Watts Bar Nuclear Power Station Unit 1 and compared to both continuous-energy Monte Carlo results and plant data.
Stability and accuracy of 3D neutron transport simulations using the 2D/1D method in MPACT
Energy Technology Data Exchange (ETDEWEB)
Collins, Benjamin, E-mail: collinsbs@ornl.gov [Oak Ridge National Laboratory, One Bethel Valley Rd., Oak Ridge, TN 37831 (United States); Stimpson, Shane, E-mail: stimpsonsg@ornl.gov [Oak Ridge National Laboratory, One Bethel Valley Rd., Oak Ridge, TN 37831 (United States); Kelley, Blake W., E-mail: kelleybl@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Young, Mitchell T.H., E-mail: youngmit@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Kochunas, Brendan, E-mail: bkochuna@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Graham, Aaron, E-mail: aarograh@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Larsen, Edward W., E-mail: edlarsen@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Downar, Thomas, E-mail: downar@umich.edu [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Godfrey, Andrew, E-mail: godfreyat@ornl.gov [Oak Ridge National Laboratory, One Bethel Valley Rd., Oak Ridge, TN 37831 (United States)
2016-12-01
A consistent “2D/1D” neutron transport method is derived from the 3D Boltzmann transport equation, to calculate fuel-pin-resolved neutron fluxes for realistic full-core Pressurized Water Reactor (PWR) problems. The 2D/1D method employs the Method of Characteristics to discretize the radial variables and a lower order transport solution to discretize the axial variable. This paper describes the theory of the 2D/1D method and its implementation in the MPACT code, which has become the whole-core deterministic neutron transport solver for the Consortium for Advanced Simulations of Light Water Reactors (CASL) core simulator VERA-CS. Several applications have been performed on both leadership-class and industry-class computing clusters. Results are presented for whole-core solutions of the Watts Bar Nuclear Power Station Unit 1 and compared to both continuous-energy Monte Carlo results and plant data.
International Nuclear Information System (INIS)
Lee, S.A.; Fairbank, W.M. Jr.; Toki, W.H.; Kraushaar, P.F. Jr.; Jaffery, T.S.
1994-01-01
The Colorado State Collaboration has studied the feasibility of a high sensitivity QED birefringence/axion search measurement. The objective of this work is to measure, for the first time, the birefringence induced in the vacuum on a light beam travelling in a powerful magnetic field. The same experimental setup also allows a highly sensitive search for axion or axion-like particles. The experiment would combined custom-designed optical heterodyne interferometry with a string of six SSC prototype superconducting dipole magnets at the N-15 site of the SSC Laboratory. With these powerful laser tools, sensitivity advances of 10 7 to 10 9 over previous optical experiments will be possible. The proposed experiment will be able to measure the QED light-by-light scattering effect with a 0.5% accuracy. The increased sensitivity for the axion-two photon interaction will result in a bound on this process rivaling the results based on astrophysical arguments. In the technical report the authors address the scientific significance of these experiments and examine the limiting technical parameters which control their feasibility. The proposed optical/electronic scheme is presented in the context of a background of the known and projected systematic problems which will confront any serious attempt to make such measurements
A facile route for 3D aerogels from nanostructured 1D and 2D materials
Jung, Sung Mi; Jung, Hyun Young; Dresselhaus, Mildred S.; Jung, Yung Joon; Kong, Jing
2012-01-01
Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of anisotropic nano-objects (one-dimensional (1D) nanotubes, nanowires, or two-dimensional (2D) nanosheets) into a cross-linking network from their colloidal suspensions at the transition from the semi-dilute to the isotropic concentrated regime. The resultant aerogels have highly porous and ultrafine three-dimensional (3D) networks consisting of 1D (Ag, Si, MnO2, single-walled carbon nanotubes (SWNTs)) and 2D materials (MoS2, graphene, h-BN) with high surface areas, low densities, and high electrical conductivities. This method opens up a facile route for aerogel production with a wide variety of materials and tremendous opportunities for bio-scaffold, energy storage, thermoelectric, catalysis, and hydrogen storage applications. PMID:23152940
D=1 supergravity and spinning particles
International Nuclear Information System (INIS)
Holten, J.W. van.
1995-01-01
In this paper I review the multiplet calculus of N-1, D=1 local supersymmetry with applications to the construction of models for spinning particles in background fields, and models with space-time supersymmetry. New features include a non-linear realization of the local supersymmetry algebra and the coupling to anti-symmetric tensor fields of both odd and even rank. The non-linear realization allows the construction of a D=1 cosmological-constant term, which provides a mass term in the equations of motion. (orig.)
Heeres, André; Van Doren, Henk A.; Gotlieb, Kees F.; Bleeker, Ido P.
1997-01-01
The title uronates were prepared by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) catalysed sodium hypochlorite oxidation of α- and β-D-glucopyranosylphosphate (α-/β-Glc-1-P) and α-D-glucopyranosyl fluoride (α-Glc-1-F). Quantitative recovery of the TEMPO catalyst was achieved by azeotropic
International Nuclear Information System (INIS)
Linderoth, T R; Horch, S; Petersen, L; Laegsgaard, E; Stensgaard, I; Besenbacher, F
2005-01-01
The technique of scanning tunnelling microscopy (STM) uniquely allows dynamic processes on surfaces to be followed directly in real space and at atomic resolution. Results for the 551225 surface diffusion of Pt adatoms and clusters on the anisotropic, missing row reconstructed Pt(110)-(1 x 2) surface are briefly reviewed. Mass transport in this system is entirely one-dimensional (1D) since, at low adatom coverage, atoms and clusters are confined to the missing row troughs. In this paper, we therefore address the question if Pt/Pt(110)-(1 x 2) is a 1D model system to study late stage growth phenomena such as island ripening? From STM measurements, we quantify the morphology changes resulting from annealing a surface configuration with small 1D Pt islands in the missing row troughs to temperatures in the interval 369-395 K. Interestingly, the resulting increase in island sizes (ripening) cannot be accounted for by the known island and adatom mobilities within a 1D model. An explanation is provided from dynamic, time-resolved 'STM-movies' that directly reveal two novel island-mediated mechanisms for inter-trough mass transport which cause the Pt/Pt(110)-(1 x 2) system not to be purely 1D at the higher surface coverage used in the annealing experiments
Comparison and analysis of 1D/2D/3D neutronics modeling for a fusion reactor
International Nuclear Information System (INIS)
Li, J.; Zeng, Q.; Chen, M.; Jiang, J.; Wu, Y.
2007-01-01
During the course of analyzing the characteristics for fusion reactors, the refined calculations are needed to confirm that the nuclear design requirements are met. Since the long computational time is consumed, the refined three-dimensional (3D) representation has been used primarily for establishing the baseline reference values, analyzing problems which cannot be reduced by symmetry considerations to lower dimensions, or where a high level of accuracy is desired locally. The two-dimensional (2D) or one-dimensional (1D) description leads itself readily to resolve many problems, such as the studies for the material fraction optimization, or for the blanket size optimization. The purpose of this paper is to find out the differences among different geometric descriptions, which can guide the way to approximate and simplify the computational model. The fusion power reactor named FDS-II was designed as an advanced fusion power reactor to demonstrate and validate the commercialization of fusion power by Institute of Plasma Physics, Chinese Academy of Science. In this contribution, the dual-cooled lithium lead (DLL) blanket of FDS-II was used as a reference for neutronics comparisons and analyses. The geometric descriptions include 1D concentric sphere model, 1D, 2D and 3D cylinder models. The home-developed multi-functional neutronics analysis code system VisualBUS, the Monte Carlo transport code MCNP and nuclear data library HENDL have been used for these analyses. The neutron wall loading distribution, tritium breeding ratio (TBR) and nuclear heat were calculated to evaluate the nuclear performance. The 3D calculation has been used as a comparison reference because it has the least errors in the treatment of geometry. It is suggested that the value of TBR calculated by the 1D approach should be greater than 1.3 to satisfy the practical need of tritium self-sufficiency. The distribution of nuclear heat based on the 2D and 3D models were similar since they all consider
Giant magnons in the D1-D5 system
International Nuclear Information System (INIS)
David, Justin R.; Sahoo, Bindusar
2008-01-01
We study giant magnons in the the D1-D5 system from both the boundary CFT and as classical solutions of the string sigma model in AdS 3 x S 3 x T 4 . Re-examining earlier studies of the symmetric product conformal field theory we argue that giant magnons in the symmetric product are BPS states in a centrally extended SU(1|1) x SU(1|1) superalgebra with two more additional central charges. The magnons carry these additional central charges locally but globally they vanish. Using a spin chain description of these magnons and the extended superalgebra we show that these magnons obey a dispersion relation which is periodic in momentum. We then identify these states on the string theory side and show that here too they are BPS in the same centrally extended algebra and obey the same dispersion relation which is periodic in momentum. This dispersion relation arises as the BPS condition for the extended algebra and is similar to that of magnons in N = 4 Yang-Mills
Analytic study of 1D diffusive relativistic shock acceleration
Energy Technology Data Exchange (ETDEWEB)
Keshet, Uri, E-mail: ukeshet@bgu.ac.il [Physics Department, Ben-Gurion University of the Negev, POB 653, Be' er-Sheva 84105 (Israel)
2017-10-01
Diffusive shock acceleration (DSA) by relativistic shocks is thought to generate the dN / dE ∝ E{sup −p} spectra of charged particles in various astronomical relativistic flows. We show that for test particles in one dimension (1D), p {sup −1}=1−ln[γ{sub d}(1+β{sub d})]/ln[γ{sub u}(1+β{sub u})], where β{sub u}(β{sub d}) is the upstream (downstream) normalized velocity, and γ is the respective Lorentz factor. This analytically captures the main properties of relativistic DSA in higher dimensions, with no assumptions on the diffusion mechanism. Unlike 2D and 3D, here the spectrum is sensitive to the equation of state even in the ultra-relativistic limit, and (for a J(üttner-Synge equation of state) noticeably hardens with increasing 1<γ{sub u}<57, before logarithmically converging back to p (γ{sub u→∞})=2. The 1D spectrum is sensitive to drifts, but only in the downstream, and not in the ultra-relativistic limit.
Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons.
Yapo, Cedric; Nair, Anu G; Clement, Lorna; Castro, Liliana R; Hellgren Kotaleski, Jeanette; Vincent, Pierre
2017-12-15
Brief dopamine events are critical actors of reward-mediated learning in the striatum; the intracellular cAMP-protein kinase A (PKA) response of striatal medium spiny neurons to such events was studied dynamically using a combination of biosensor imaging in mouse brain slices and in silico simulations. Both D1 and D2 medium spiny neurons can sense brief dopamine transients in the sub-micromolar range. While dopamine transients profoundly change cAMP levels in both types of medium spiny neurons, the PKA-dependent phosphorylation level remains unaffected in D2 neurons. At the level of PKA-dependent phosphorylation, D2 unresponsiveness depends on protein phosphatase-1 (PP1) inhibition by DARPP-32. Simulations suggest that D2 medium spiny neurons could detect transient dips in dopamine level. The phasic release of dopamine in the striatum determines various aspects of reward and action selection, but the dynamics of the dopamine effect on intracellular signalling remains poorly understood. We used genetically encoded FRET biosensors in striatal brain slices to quantify the effect of transient dopamine on cAMP or PKA-dependent phosphorylation levels, and computational modelling to further explore the dynamics of this signalling pathway. Medium-sized spiny neurons (MSNs), which express either D 1 or D 2 dopamine receptors, responded to dopamine by an increase or a decrease in cAMP, respectively. Transient dopamine showed similar sub-micromolar efficacies on cAMP in both D1 and D2 MSNs, thus challenging the commonly accepted notion that dopamine efficacy is much higher on D 2 than on D 1 receptors. However, in D2 MSNs, the large decrease in cAMP level triggered by transient dopamine did not translate to a decrease in PKA-dependent phosphorylation level, owing to the efficient inhibition of protein phosphatase 1 by DARPP-32. Simulations further suggested that D2 MSNs can also operate in a 'tone-sensing' mode, allowing them to detect transient dips in basal dopamine
Mossine, Valeri V.; Barnes, Charles L.; Mawhinney, Thomas P.
2018-05-01
Sorbosamine and psicosamine are the last two 1-amino-1-deoxy-hexuloses for which no structural data were available. We report on a13C NMR and a single crystal X-ray diffraction study of 1-deoxy-1-(N-methylphenylamino)-D-sorbose (1) and 1-deoxy-1-(N-methylphenylamino)-D-psicose (2). In solutions, both aminosugars are conformationally unstable and establish equilibria, with 90.7% α-pyranose, 3.8% α-furanose, 1.0% β-pyranose, 0.5% β-furanose, and 4.0% acyclic keto form for 1 and 32.4% α-furanose, 27.2% α-pyranose, 21.0% β-pyranose, 9.1% β-furanose, and 11.0% acyclic keto form for 2. X-ray diffraction data provided detailed structural information on 1 and 2 in the α-pyranose form. Both molecules adopt the 5C2 ring conformations, the bond distances and valence angles compare well with respective pyranose structures. All hydroxyl groups in crystal structures of both 1 and 2 participate in two-dimensional hydrogen bonding networks, the H-bonding pattern in 1 is dominated by co-crystallized water molecules. The Hirshfeld surface analysis revealed a significant contribution of non- or weakly polar interactions to the packing forces for both molecules, with crystal structure of 2 featuring short H⋯H contacts. Other structural features found in 2 are a significant planarity of the tertiary amino group (the pyramid heights are 0.127 Å in 2 vs 0.231 Å in 1), a concomitant non-involvement of the amine nitrogen in heteroatom contacts, and a unique anti-periplanar conformation around the C1sbnd C2 bond.
Birefringent dispersive FDTD subgridding scheme
De Deckere, B; Van Londersele, Arne; De Zutter, Daniël; Vande Ginste, Dries
2016-01-01
A novel 2D finite difference time domain (FDTD) subgridding method is proposed, only subject to the Courant limit of the coarse grid. By making mu or epsilon inside the subgrid dispersive, unconditional stability is induced at the cost of a sparse, implicit set of update equations. By only adding dispersion along preferential directions, it is possible to dramatically reduce the rank of the matrix equation that needs to be solved.
Xin, Ling-Yun; Liu, Guang-Zhen; Wang, Li-Ya
2011-06-01
The hydrothermal reactions of Cd, Zn, or Cu(II) acetate salts with H 2PHDA and BPP flexible ligands afford three new coordination polymers, including [Cd(PHDA)(BPP)(H 2O)] n(1), [Zn(PHDA)(BPP)] n(2), and [Cu 2(PHDA) 2(BPP)] n(3) (H 2PHDA=1,2-phenylenediacetic acid, BPP=1,3-bis(4-pyridyl)propane). The single-crystal X-ray diffractions reveal that all three complexes feature various metal carboxylate subunits extended further by the BPP ligands to form a diverse range of structures, displaying a remarked structural sensitivity to metal(II) cation. Complex 1 containing PHDA-bridged binuclear cadmium generates 1D double-stranded chain, complex 2 results in 2D→2D interpenetrated (4,4) grids, and complex 3 displays a 3D self-penetrated framework with 4 86 68 rob topology. In addition, fluorescent analyses show that both 1 and 2 exhibit intense blue-violet photoluminescence in the solid state.
Li, Jin Hua; Xu, Hui; Sun, Ting Ting; Pei, Shi Xin; Ren, Hai Dong
2018-05-01
We analyze in detail the effects of the intermode nonlinearity (IEMN) and intramode nonlinearity (IRMN) on modulation instability (MI) in randomly birefringent two-mode optical fibers (RB-TMFs). In the anomalous dispersion regime, the MI gain enhances significantly as the IEMN and IRMN coefficients increases. In the normal dispersion regime, MI can be generated without the differential mode group delay (DMGD) effect, as long as the IEMN coefficient between two distinct modes is above a critical value, or the IRMN coefficient inside a mode is below a critical value. This critical IEMN (IRMN) coefficient depends strongly on the given IRMN (IEMN) coefficient and DMGD for a given nonlinear RB-TMF structure, and is independent on the input total power, the power ratio distribution and the group velocity dispersion (GVD) ratio between the two modes. On the other hand, in contrast to the MI band arising from the pure effect of DMGD in the normal dispersion regime, where MI vanishes after a critical total power, the generated MI band under the combined effects of IEMN and IRMN without DMGD exists for any total power and enhances with the total power. The MI analysis is verified numerically by launching perturbed continuous waves (CWs) with wave propagation method.
Directory of Open Access Journals (Sweden)
2008-08-01
Full Text Available Two methacrylate monomers containing azo and electronical push and pull structure, e.g. 2-Methyl-acrylic-acid-2-{[4-(4-cyano-phenylazo-3-methyl-phenyl]-ethyl-amino-ethyl ester (MACP with cyano substituted and 2-Methylacrylic-acid-2-{ethyl-[4-(4-methoxy-phenylazo-3-methyl-phenyl]-amino}-ethyl ester (MAMP with methoxy substituted, were synthesized and polymerized using 2-cyanoprop-2-yl dithiobenzoate (CPDB as chain transfer agent and 2,2'-azobisisobutyronitrile (AIBN as initiator. The results showed that the polymerization displayed characteristics of ‘living’/controlled free radical polymerization. Thus, the obtained polymers, polyMACP (pMACP and polyMAMP (pMAMP, had controlled molecular weights and narrow molecular weights distribution. The chain extension experiments of pMACP and pMAMP using styrene as the second monomer were successfully carried out. The photo-induced trans-cis-trans isomerization kinetic of pMACP and pMAMP in chloroform solution were described. Marked differences in rate for the trans-cis and cis-trans isomerization of pMACP and pMAMP were observed in chloroform solution due to the different electronic effects in these two polymers. Photoinduced birefringence and surface relief grating (SRG of the pMACP and pMAMP were investigated in thin film state.
Gianaroli, Luca; Magli, M Cristina; Ferraretti, Anna P; Crippa, Andor; Lappi, Michela; Capitani, Serena; Baccetti, Baccio
2010-02-01
To verify clinical outcome after injection of spermatozoa that have undergone the acrosome reaction (reacted spermatozoa) vs. those still having an intact acrosome (nonreacted spermatozoa). Prospective, randomized study. Reproductive Medicine Unit, Italian Society for the Study of Reproductive Medicine, Bologna, Italy. According to a prospective randomization including 71 couples with severe male factor infertility, intracytoplasmic sperm injection (ICSI) was performed under polarized light that permitted analysis of the pattern of birefringence in the sperm head. Twenty-three patients had their oocytes injected with reacted spermatozoa, 26 patient's oocytes were injected with nonreacted spermatozoa, and in 22 patients both reacted and nonreacted spermatozoa were injected. Intracytoplasmic sperm injection was performed under polarized light to selectively inject acrosome-reacted and acrosome-nonreacted spermatozoa. Rates of fertilization, cleavage, pregnancy, implantation, and ongoing implantation. There was no effect on the fertilizing capacity and embryo development of either type of sperm, whereas the implantation rate was higher in oocytes injected with reacted spermatozoa (39.0%) vs. those injected with nonreacted spermatozoa (8.6%). The implantation rate was 24.4% in the group injected with both reacted and nonreacted spermatozoa. The delivery rate per cycle followed the same trend. Spermatozoa that have undergone the acrosome reaction seem to be more prone to supporting the development of viable ICSI embryos. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain
International Nuclear Information System (INIS)
Seeman, P.; Niznik, H.B.; Guan, H.C.; Booth, G.; Ulpian, C.
1989-01-01
Dopamine receptor types D 1 and D 2 can oppose enhance each other's actions for electrical, biochemical, and psychomotor effects. The authors report a D 1 -D 2 interaction in homogenized tissue as revealed by ligand binding. D 2 agonists lowered the binding of [ 3 H]raclopride to D 2 receptors in striatal and anterior pituitary tissues. Pretreating the tissue with the D 1 -selective antagonist SCH 23390 prevented the agonist-induced decrease in [ 3 H]raclopride binding to D 2 sites in the striatum but not in the anterior pituitary, which has no D 1 receptors. Conversely, a dopamine-induced reduction in the binding of [ 3 H]SCH 23390 to D 1 receptors could be prevented by the D 2 -selective antagonist eticlopride. Receptor photolabeling experiments confirmed both these D 1 -D 2 interactions. The blocking effect by SCH 23390 was similar to that produced by a nonhydrolyzable guanine nucleotide analogue, and SCH 23390 reduced the number of agonist-labeled D 2 receptors in the high-affinity state. Thus, the D 1 -D 2 link may be mediated by guanine nucleotide-binding protein components. The link may underlie D 1 -D 2 interactions influencing behavior, since the link was missing in over half the postmortem striata from patients with schizophrenia and Huntington disease (both diseases that show some hyperdopamine signs) but was present in human control, Alzheimer, and Parkinson striata
On QCD Q2-evolution of deuteron structure function F2D(xD, Q2) for xD>1
International Nuclear Information System (INIS)
Sidorov, A.V.; Tokarev, M.V.
1995-01-01
The deep-inelastic deuteron structure function (SF) F 2 D (x D ,Q 2 ) in the covariant approach in light-cone variables is considered. The x D and Q 2 -dependences of SF are calculated. The QCD analysis of generated data both for non-cumulative x D D >1 ranges was performed. It was shown that Q 2 -evolution of SF is valid for ranges 0.275 D D D -dependence of SF for the ranges is essentially different. 23 refs., 2 figs., 1 tab
Data of evolutionary structure change: 1A96D-1VDMG [Confc[Archive
Lifescience Database Archive (English)
Full Text Available 1A96D-1VDMG 1A96 1VDM D G -EKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGL...VPGALLARELGIRHVDTVCISSY-------RELKVLKRAEGDGEG--FIVIDDLVDTGGTAVAIREMYP-----KAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMG...Chain>G 1VDMG IEEVKKLGAKEIKIA G 1VDMG LREYK-PDVI...pdbID> G 1VDMG YVFRT--EKWIV
Sexual behavior modulates contextual fear memory through dopamine D1/D5 receptors.
Bai, Hua-Yi; Cao, Jun; Liu, Na; Xu, Lin; Luo, Jian-Hong
2009-03-01
Traumatic events always lead to aversive emotional memory, i.e., fear memory. In contrast, positive events in daily life such as sex experiences seem to reduce aversive memory after aversive events. Thus, we hypothesized that post-traumatic pleasurable experiences, especially instinctive behaviors such as sex, might modulate traumatic memory through a memory competition mechanism. Here, we first report that male rats persistently expressed much lower fear responses when exposed to females, but not when exposed to males, for 24 h immediately after contextual fear conditioning. Remarkably, this effect of sexual behavior was blocked by either systemic or intrahippocampal injection of the dopamine D1/D5 receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) and was mimicked by systemic but not intrahippocampal injection of the D1/D5 receptor agonist R(+)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrochloride (SKF39393). Furthermore, as a candidate mechanism underlying contextual fear memory, the impaired induction of hippocampal long-term potentiation (LTP) elicited by conditioned fear was rescued in male rats immediately exposed to female but not male rats for 24 h. Systemic injection of the dopamine D1/D5 receptor antagonist SCH23390 or agonist SKF38393 prevented or mimicked the effect of sexual behavior on the impaired induction of hippocampal LTP. Thus, our finding suggests that dopaminergic functions may, at least partially, govern competition between contextual fear and enjoyable memories through the modulation of hippocampal LTP.
Optical coherence tomography based 1D to 6D eye-in-hand calibration
DEFF Research Database (Denmark)
Antoni, Sven Thomas; Otte, Christoph; Savarimuthu, Thiusius Rajeeth
2017-01-01
and based on this introduce pivot+d, a new 1D to 6D eye-in-hand calibration. We provide detailed results on the convergence and accuracy of our method and use translational and rotational ground truth to show that our methods allow for submillimeter positioning accuracy of an OCT beam with a robot.......e., it can be easily integrated with instruments. However, to use OCT for intra-operative guidance its spatial alignment needs to be established. Hence, we consider eye-in-hand calibration between the 1D OCT imaging and a 6D robotic position system. We present a method to perform pivot calibration for OCT....... For pivot calibration we observe a mean translational error of 0.5161 ± 0.4549 mm while pivot+d shows 0.3772 ± 0.2383 mm. Additionally, pivot+d improves rotation detection by about 8° when compared to pivot calibration....
Fully digital 1-D, 2-D and 3-D multiscroll chaos as hardware pseudo random number generators
Mansingka, Abhinav S.
2012-10-07
This paper introduces the first fully digital implementation of 1-D, 2-D and 3-D multiscroll chaos using the sawtooth nonlinearity in a 3rd order ODE with the Euler approximation. Systems indicate chaotic behaviour through phase space boundedness and positive Lyapunov exponent. Low-significance bits form a PRNG and pass all tests in the NIST SP. 800-22 suite without post-processing. Real-time control of the number of scrolls allows distinct output streams with 2-D and 3-D multiscroll chaos enabling greater controllability. The proposed PRNGs are experimentally verified on a Xilinx Virtex 4 FPGA with logic utilization less than 1.25%, throughput up to 5.25 Gbits/s and up to 512 distinct output streams with low cross-correlation.
Fully digital 1-D, 2-D and 3-D multiscroll chaos as hardware pseudo random number generators
Mansingka, Abhinav S.; Radwan, Ahmed Gomaa; Salama, Khaled N.
2012-01-01
This paper introduces the first fully digital implementation of 1-D, 2-D and 3-D multiscroll chaos using the sawtooth nonlinearity in a 3rd order ODE with the Euler approximation. Systems indicate chaotic behaviour through phase space boundedness
1-/sup 11/C-D-glucose and related compounds
Energy Technology Data Exchange (ETDEWEB)
Shiue, C.Y.; Wolf, A.P.
1982-01-26
The novel compounds 1-/sup 11/C-D-glucose, 1-/sup 11/C-D-mannose, 1-/sup 11/C-D-galactose, 2-/sup 11/C-D-glucose, 2-/sup 11/C-D-mannose and 2-/sup 11/C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal /sup 11/C-labeled cyanide followed by reduction with a Raney alloy in formic acid.
1D ferromagnetic edge contacts to 2D graphene/h-BN heterostructures
Karpiak, Bogdan; Dankert, André; Cummings, Aron W.; Power, Stephen R.; Roche, Stephan; Dash, Saroj P.
2018-03-01
We report the fabrication of one-dimensional (1D) ferromagnetic edge contacts to two-dimensional (2D) graphene/h-BN heterostructures. While aiming to study spin injection/detection with 1D edge contacts, a spurious magnetoresistance signal was observed, which is found to originate from the local Hall effect in graphene due to fringe fields from ferromagnetic edge contacts and in the presence of charge current spreading in the nonlocal measurement configuration. Such behavior has been confirmed by the absence of a Hanle signal and gate-dependent magnetoresistance measurements that reveal a change in sign of the signal for the electron- and hole-doped regimes, which is in contrast to the expected behavior of the spin signal. Calculations show that the contact-induced fringe fields are typically on the order of hundreds of mT, but can be reduced below 100 mT with careful optimization of the contact geometry. There may be an additional contribution from magnetoresistance effects due to tunneling anisotropy in the contacts, which needs further investigation. These studies are useful for optimization of spin injection and detection in 2D material heterostructures through 1D edge contacts.
Production of the excited charm mesons D{sub 1} and D{sup *}{sub 2} at HERA
Energy Technology Data Exchange (ETDEWEB)
Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max Planck Institute for Physics, Munich (Germany); Abt, I. [Max Planck Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (Poland). Faculty of Physics and Applied Computer Science] [and others; Collaboration: ZEUS Collaboration
2012-08-15
The production of the excited charm mesons D{sub 1}(2420) and D{sup *}{sub 2}(2460) in ep collisions has been measured with the ZEUS detector at HERA using an integrated luminosity of 373 pb{sup -1}. The masses of the neutral and charged states, the widths of the neutral states, and the helicity parameter of D{sub 1}(2420){sup 0} were determined and compared with other measurements and with theoretical expectations. The measured helicity parameter of the D{sup 0}{sub 1} allows for some mixing of S- and D-waves in its decay to D{sup *{+-}}{pi}{sup -+}. The result is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D{sup *}{sub 2}(2460){sup 0} and D{sup *}{sub 2}(2460){sup {+-}} states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D{sub 1} and D{sup *}{sub 2} were measured and are consistent with those obtained in e{sup +}e{sup -} annihilations.
Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi
Directory of Open Access Journals (Sweden)
Peter M. Dracatos
2016-09-01
Full Text Available Nicotiana alata defensins 1 and 2 (NaD1 and NaD2 are plant defensins from the ornamental tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins interact with fungal cell wall O-glycosylated proteins. Therefore, we investigated if this was the case for NaD1 and NaD2, by assessing the sensitivity of the three Aspergillus nidulans (An O-mannosyltransferase (pmt knockout (KO mutants (An∆pmtA, An∆pmtB, and An∆pmtC. An∆pmtA was resistant to both defensins, while An∆pmtC was resistant to NaD2 only, suggesting NaD1 and NaD2 are unlikely to have a general interaction with O-linked side chains. Further evidence of this difference in the antifungal mechanism was provided by the dissimilarity of the NaD1 and NaD2 sensitivities of the Fusarium oxysporum f. sp. lycopersici (Fol signalling knockout mutants from the cell wall integrity (CWI and high osmolarity glycerol (HOG mitogen-activated protein kinase (MAPK pathways. HOG pathway mutants were sensitive to both NaD1 and NaD2, while CWI pathway mutants only displayed sensitivity to NaD2.
Data of evolutionary structure change: 1B26D-1AUPA [Confc[Archive
Lifescience Database Archive (English)
Full Text Available 1B26D-1AUPA 1B26 1AUP D A ------------------SLYEMAVEQFN----RA----...ine> GLU CA 284 LEU CA 369 1AUP A 1AUPA DPEGITTEEKINY ALA CA 419 ALA CA 500 1AUP... A 1AUPA RYGLGYNLVAGA
Experimental Conditions: SE24_S1_M1_D1 [Metabolonote[Archive
Lifescience Database Archive (English)
Full Text Available rometry with 13C‑Labeling for Chemical Assignment of Sulfur-Containing Metabolites ...SE24_S1_M1_D1 SE24 Combination of Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance-Mass Spect
Zikhali, Meluleki; Wingen, Luzie U.; Griffiths, Simon
2016-01-01
Earliness per se (Eps) genes account for the variation in flowering time when vernalization and photoperiod requirements are satisfied. Genomics and bioinformatics approaches were used to describe allelic variation for 40 Triticum aestivum genes predicted, by synteny with Brachypodium distachyon, to be in the 1DL Eps region. Re-sequencing 1DL genes revealed that varieties carrying early heading alleles at this locus, Spark and Cadenza, carry a subtelomeric deletion including several genes. The equivalent region in Rialto and Avalon is intact. A bimodal distribution in the segregating Spark X Rialto single seed descent (SSD) populations enabled the 1DL QTL to be defined as a discrete Mendelian factor, which we named Eps-D1. Near isogenic lines (NILs) and NIL derived key recombinants between markers flanking Eps-D1 suggest that the 1DL deletion contains the gene(s) underlying Eps-D1. The deletion spans the equivalent of the Triticum monoccocum Eps-A m 1 locus, and hence includes MODIFIER OF TRANSCRIPTION 1 (MOT1) and FTSH PROTEASE 4 (FTSH4), the candidates for Eps-A m 1. The deletion also contains T. aestivum EARLY FLOWERING 3-D1 (TaELF3-D1) a homologue of the Arabidopsis thaliana circadian clock gene EARLY FLOWERING 3. Eps-D1 is possibly a homologue of Eps-B1 on chromosome 1BL. NILs carrying the Eps-D1 deletion have significantly reduced total TaELF3 expression and altered TaGIGANTEA (TaGI) expression compared with wild type. Altered TaGI expression is consistent with an ELF3 mutant, hence we propose TaELF3-D1 as the more likely candidate for Eps-D1. This is the first direct fine mapping of Eps effect in bread wheat. PMID:26476691
Zikhali, Meluleki; Wingen, Luzie U; Griffiths, Simon
2016-01-01
Earliness per se (Eps) genes account for the variation in flowering time when vernalization and photoperiod requirements are satisfied. Genomics and bioinformatics approaches were used to describe allelic variation for 40 Triticum aestivum genes predicted, by synteny with Brachypodium distachyon, to be in the 1DL Eps region. Re-sequencing 1DL genes revealed that varieties carrying early heading alleles at this locus, Spark and Cadenza, carry a subtelomeric deletion including several genes. The equivalent region in Rialto and Avalon is intact. A bimodal distribution in the segregating Spark X Rialto single seed descent (SSD) populations enabled the 1DL QTL to be defined as a discrete Mendelian factor, which we named Eps-D1. Near isogenic lines (NILs) and NIL derived key recombinants between markers flanking Eps-D1 suggest that the 1DL deletion contains the gene(s) underlying Eps-D1. The deletion spans the equivalent of the Triticum monoccocum Eps-A (m) 1 locus, and hence includes MODIFIER OF TRANSCRIPTION 1 (MOT1) and FTSH PROTEASE 4 (FTSH4), the candidates for Eps-A (m) 1. The deletion also contains T. aestivum EARLY FLOWERING 3-D1 (TaELF3-D1) a homologue of the Arabidopsis thaliana circadian clock gene EARLY FLOWERING 3. Eps-D1 is possibly a homologue of Eps-B1 on chromosome 1BL. NILs carrying the Eps-D1 deletion have significantly reduced total TaELF3 expression and altered TaGIGANTEA (TaGI) expression compared with wild type. Altered TaGI expression is consistent with an ELF3 mutant, hence we propose TaELF3-D1 as the more likely candidate for Eps-D1. This is the first direct fine mapping of Eps effect in bread wheat. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.
Cell Migration in 1D and 2D Nanofiber Microenvironments.
Estabridis, Horacio M; Jana, Aniket; Nain, Amrinder; Odde, David J
2018-03-01
Understanding how cells migrate in fibrous environments is important in wound healing, immune function, and cancer progression. A key question is how fiber orientation and network geometry influence cell movement. Here we describe a quantitative, modeling-based approach toward identifying the mechanisms by which cells migrate in fibrous geometries having well controlled orientation. Specifically, U251 glioblastoma cells were seeded onto non-electrospinning Spinneret based tunable engineering parameters fiber substrates that consist of networks of suspended 400 nm diameter nanofibers. Cells were classified based on the local fiber geometry and cell migration dynamics observed by light microscopy. Cells were found in three distinct geometries: adhering two a single fiber, adhering to two parallel fibers, and adhering to a network of orthogonal fibers. Cells adhering to a single fiber or two parallel fibers can only move in one dimension along the fiber axis, whereas cells on a network of orthogonal fibers can move in two dimensions. We found that cells move faster and more persistently in 1D geometries than in 2D, with cell migration being faster on parallel fibers than on single fibers. To explain these behaviors mechanistically, we simulated cell migration in the three different geometries using a motor-clutch based model for cell traction forces. Using nearly identical parameter sets for each of the three cases, we found that the simulated cells naturally replicated the reduced migration in 2D relative to 1D geometries. In addition, the modestly faster 1D migration on parallel fibers relative to single fibers was captured using a correspondingly modest increase in the number of clutches to reflect increased surface area of adhesion on parallel fibers. Overall, the integrated modeling and experimental analysis shows that cell migration in response to varying fibrous geometries can be explained by a simple mechanical readout of geometry via a motor-clutch mechanism.
Impact of CD1d deficiency on metabolism.
Directory of Open Access Journals (Sweden)
Maya E Kotas
Full Text Available Invariant natural killer T cells (iNKTs are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d. Although capable of a myriad of responses, few essential functions have been described for iNKTs. Among the many cell types of the immune system implicated in metabolic control and disease, iNKTs seem ideally poised for such a role, yet little has been done to elucidate such a possible function. We hypothesized that lipid presentation by CD1d could report on metabolic status and engage iNKTs to regulate cellular lipid content through their various effector mechanisms. To test this hypothesis, we examined CD1d deficient mice in a variety of metabolically stressed paradigms including high fat feeding, choline-deficient feeding, fasting, and acute inflammation. CD1d deficiency led to a mild exacerbation of steatosis during high fat or choline-deficient feeding, accompanied by impaired hepatic glucose tolerance. Surprisingly, however, this phenotype was not observed in Jα18⁻/⁻ mice, which are deficient in iNKTs but express CD1d. Thus, CD1d appears to modulate some metabolic functions through an iNKT-independent mechanism.
Cyclin d1 expression in odontogenic cysts.
Taghavi, Nasim; Modabbernia, Shirin; Akbarzadeh, Alireza; Sajjadi, Samad
2013-01-01
In the present study expression of cyclin D1 in the epithelial lining of odontogenic keratocyst, radicular cyst, dentigerous cyst and glandular odontogenic cyst was investigated to compare proliferative activity in these lesions. Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n=23), dentigerous cysts (n=20), radicular cysts (n=20) and glandular odontogenic cysts (n=5) was performed by standard EnVision method. Then, slides were studied to evaluate the following parameters in epithelial lining of cysts: expression, expression pattern, staining intensity and localization of expression. The data analysis showed statistically significant difference in cyclin D1 expression in studied groups (p keratocysts, but difference was not statistically significant among groups respectively (p=0.204, 0.469). Considering expression localization, cyclin D1 positive cells in odontogenic keratocysts and dentigerous cysts were frequently confined in parabasal layer, different from radicular cysts and glandular odontogenic cysts. The difference was statistically significant (p keratocyst and the entire cystic epithelium of glandular odontogenic cysts comparing to dentigerous cysts and radicular cysts, implying the possible role of G1-S cell cycle phase disturbances in the aggressiveness of odontogenic keratocyst and glandular odontogenic cyst.
Moreno, Estefanía; Moreno-Delgado, David; Navarro, Gemma; Hoffmann, Hanne M.; Fuentes, Silvia; Rosell-Vilar, Santi; Gasperini, Paola; Rodríguez-Ruiz, Mar; Medrano, Mireia; Mallol, Josefa; Cortés, Antoni; Casadó, Vicent; Lluís, Carme; Ferré, Sergi; Ortiz, Jordi; Canela, Enric
2014-01-01
The general effects of cocaine are not well understood at the molecular level. What is known is that the dopamine D1 receptor plays an important role. Here we show that a key mechanism may be cocaine's blockade of the histamine H3 receptor-mediated inhibition of D1 receptor function. This blockade requires the σ1 receptor and occurs upon cocaine binding to σ1-D1-H3 receptor complexes. The cocaine-mediated disruption leaves an uninhibited D1 receptor that activates Gs, freely recruits β-arrestin, increases p-ERK 1/2 levels, and induces cell death when over activated. Using in vitro assays with transfected cells and in ex vivo experiments using both rats acutely treated or self-administered with cocaine along with mice depleted of σ1 receptor, we show that blockade of σ1 receptor by an antagonist restores the protective H3 receptor-mediated brake on D1 receptor signaling and prevents the cell death from elevated D1 receptor signaling. These findings suggest that a combination therapy of σ1R antagonists with H3 receptor agonists could serve to reduce some effects of cocaine. PMID:24599455
Energy Technology Data Exchange (ETDEWEB)
Maiuri, Margherita [CNR-IFN, Dipartimento di Fisica, Politecnico di Milano, P.zza L. da Vinci 32, Milano 20133 (Italy); Department of Chemistry, Princeton University, Washington Road, Princeton, New Jersey 08544 (United States); Réhault, Julien; Polli, Dario; Cerullo, Giulio, E-mail: giulio.cerullo@polimi.it [CNR-IFN, Dipartimento di Fisica, Politecnico di Milano, P.zza L. da Vinci 32, Milano 20133 (Italy); Carey, Anne-Marie; Hacking, Kirsty; Cogdell, Richard J. [Glasgow Biomedical Research Centre, IBLS, University of Glasgow, 126 Place, Glasgow G12 8TA, Scotland (United Kingdom); Garavelli, Marco [Dipartimento di Chimica “G. Ciamician,” Università di Bologna, Via Selmi 2, IT-40126 Bologna (Italy); CNRS, Institut de Chimie de Lyon, École Normale Supérieure de Lyon, Université de Lyon, 46 Allée d’Italie, F-69364 Lyon Cedex 07 (France); Lüer, Larry [Madrid Institute for Advanced Studies, IMDEA Nanociencia, Madrid (Spain)
2015-06-07
We investigate the excitation energy transfer (EET) pathways in the photosynthetic light harvesting 1 (LH1) complex of purple bacterium Rhodospirillum rubrum with ultra-broadband two-dimensional electronic spectroscopy (2DES). We employ a 2DES apparatus in the partially collinear geometry, using a passive birefringent interferometer to generate the phase-locked pump pulse pair. This scheme easily lends itself to two-color operation, by coupling a sub-10 fs visible pulse with a sub-15-fs near-infrared pulse. This unique pulse combination allows us to simultaneously track with extremely high temporal resolution both the dynamics of the photoexcited carotenoid spirilloxanthin (Spx) in the visible range and the EET between the Spx and the B890 bacterio-chlorophyll (BChl), whose Q{sub x} and Q{sub y} transitions peak at 585 and 881 nm, respectively, in the near-infrared. Global analysis of the one-color and two-color 2DES maps unravels different relaxation mechanisms in the LH1 complex: (i) the initial events of the internal conversion process within the Spx, (ii) the parallel EET from the first bright state S{sub 2} of the Spx towards the Q{sub x} state of the B890, and (iii) the internal conversion from Q{sub x} to Q{sub y} within the B890.
$D^{0}, D^{+}, D_{s}^{+}$, and $\\Lambda_{c}^{+}$ Fragmentation Functions from CERN LEP1
Kniehl, Bernd A; Kniehl, Bernd A.; Kramer, Gustav
2005-01-01
We present new sets of nonperturbative fragmentation functions for D^0, D^+, and D_s^+ mesons as well as for Lambda_c^+ baryons, both at leading and next-to-leading order in the MSbar factorization scheme with five massless quark flavors. They are determined by fitting data of e^+e^- annihilation taken by the OPAL Collaboration at CERN LEP1. We take the charm-quark fragmentation function to be of the form proposed by Peterson et al. and thus obtain new values of the epsilon_c parameter, which are specific for our choice of factorization scheme.
Jeevanandham, Balaji; Kalyanpur, Tejas; Gupta, Prashant; Cherian, Mathew
2017-06-01
This study was to assess the usefulness of newer three-dimensional (3D)-T 1 sampling perfection with application optimized contrast using different flip-angle evolutions (SPACE) and 3D-T 2 fluid-attenuated inversion recovery (FLAIR) sequences in evaluation of meningeal abnormalities. 78 patients who presented with high suspicion of meningeal abnormalities were evaluated using post-contrast 3D-T 2 -FLAIR, 3D-T 1 magnetization-prepared rapid gradient-echo (MPRAGE) and 3D-T 1 -SPACE sequences. The images were evaluated independently by two radiologists for cortical gyral, sulcal space, basal cisterns and dural enhancement. The diagnoses were confirmed by further investigations including histopathology. Post-contrast 3D-T 1 -SPACE and 3D-T 2 -FLAIR images yielded significantly more information than MPRAGE images (p evaluation of meningeal abnormalities and when used in combination have the maximum sensitivity for leptomeningeal abnormalities. The negative-predictive value is nearly 100%, where no leptomeningeal abnormality was detected on these sequences. Advances in knowledge: Post-contrast 3D-T 1 -SPACE and 3D-T 2 -FLAIR images are more useful than 3D-T 1 -MPRAGE images in evaluation of meningeal abnormalities.
Energy Device Applications of Synthesized 1D Polymer Nanomaterials.
Huang, Long-Biao; Xu, Wei; Hao, Jianhua
2017-11-01
1D polymer nanomaterials as emerging materials, such as nanowires, nanotubes, and nanopillars, have attracted extensive attention in academia and industry. The distinctive, various, and tunable structures in the nanoscale of 1D polymer nanomaterials present nanointerfaces, high surface-to-volume ratio, and large surface area, which can improve the performance of energy devices. In this review, representative fabrication techniques of 1D polymer nanomaterials are summarized, including electrospinning, template-assisted, template-free, and inductively coupled plasma methods. The recent advancements of 1D polymer nanomaterials in energy device applications are demonstrated. Lastly, existing challenges and prospects of 1D polymer nanomaterials for energy device applications are presented. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
International Nuclear Information System (INIS)
Foda, O.
1984-12-01
The effective potential of components of the curl of an antisymmetric tensor coupled to gravity in D dimensions is evaluated in a 1/D expansion. For large D, only highest-rank propagators contribute to leading order, while multiloop diagrams are suppressed by phase-space factors. Divergences are regulated by a cut-off LAMBDA, that we interpret as the mass-breaking scale of a larger theory that is finite. As an application we consider the bosonic sector of D=11, N=1 supergravity. If the full theory is finite, then LAMBDA is msub(SUSY): the scale below which the fermion sector decouples. For m 9 sub(SUSY)>1/akappa 2 , (kappa 2 : the D=11 Newton's coupling, a approx.= O(1)) the 11-dimensional symmetric vacuum is unstable under compactification. For m 9 sub(SUSY) 2 , it is metastable. To leading order in 1/D, all gauge dependence cancels identically, while ghosts as well as the graviton decouple. (author)
Vertically integrated ZnO-Based 1D1R structure for resistive switching
International Nuclear Information System (INIS)
Zhang Yang; Duan Ziqing; Li Rui; Ku, Chieh-Jen; Reyes, Pavel I; Ashrafi, Almamun; Zhong Jian; Lu Yicheng
2013-01-01
We report a ZnO-based 1D1R structure, which is formed by a vertical integration of a FeZnO/MgO switching resistor (1R) and an Ag/MgZnO Schottky diode (1D). The multifunctional ZnO and its compounds are grown through MOCVD with in situ doping. For the R element, the current ratio of the high-resistance state (HRS) over the low-resistance state (LRS) at 1 V is 2.4 × 10 6 . The conduction mechanisms of the HRS and LRS are Poole–Frenkel emission and resistive conduction, respectively. The D element shows the forward/reverse current ratio at ±1 V to be 2.4 × 10 7 . This 1D1R structure exhibits high R HRS /R LRS ratio, excellent rectifying characteristics and robust retention. (paper)
Severe Hypertriglyceridemia in Glut1D on Ketogenic Diet.
Klepper, Joerg; Leiendecker, Baerbel; Heussinger, Nicole; Lausch, Ekkehart; Bosch, Friedrich
2016-04-01
High-fat ketogenic diets are the only treatment available for Glut1 deficiency (Glut1D). Here, we describe an 8-year-old girl with classical Glut1D responsive to a 3:1 ketogenic diet and ethosuximide. After 3 years on the diet a gradual increase of blood lipids was followed by rapid, severe asymptomatic hypertriglyceridemia (1,910 mg/dL). Serum lipid apheresis was required to determine liver, renal, and pancreatic function. A combination of medium chain triglyceride-oil and a reduction of the ketogenic diet to 1:1 ratio normalized triglyceride levels within days but triggered severe myoclonic seizures requiring comedication with sultiam. Severe hypertriglyceridemia in children with Glut1D on ketogenic diets may be underdiagnosed and harmful. In contrast to congenital hypertriglyceridemias, children with Glut1D may be treated effectively by dietary adjustments alone. Georg Thieme Verlag KG Stuttgart · New York.
International Nuclear Information System (INIS)
Upadhyay, Santosh Kumar; Verone, Alissa; Shoemaker, Suzanne; Qin, Maochun; Liu, Song; Campbell, Moray; Hershberger, Pamela A.
2013-01-01
1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) exerts anti-proliferative activity by binding to the vitamin D receptor (VDR) and regulating gene expression. We previously reported that non-small cell lung cancer (NSCLC) cells which harbor epidermal growth factor receptor (EGFR) mutations display elevated VDR expression (VDR high ) and are vitamin D-sensitive. Conversely, those with K-ras mutations are VDR low and vitamin D-refractory. Because EGFR mutations are found predominately in NSCLC cells with an epithelial phenotype and K-ras mutations are more common in cells with a mesenchymal phenotype, we investigated the relationship between vitamin D signaling capacity and the epithelial mesenchymal transition (EMT). Using NSCLC cell lines and publically available lung cancer cell line microarray data, we identified a relationship between VDR expression, 1,25(OH) 2 D 3 sensitivity, and EMT phenotype. Further, we discovered that 1,25(OH) 2 D 3 induces E-cadherin and decreases EMT-related molecules SNAIL, ZEB1, and vimentin in NSCLC cells. 1,25(OH) 2 D 3 -mediated changes in gene expression are associated with a significant decrease in cell migration and maintenance of epithelial morphology. These data indicate that 1,25(OH) 2 D 3 opposes EMT in NSCLC cells. Because EMT is associated with increased migration, invasion, and chemoresistance, our data imply that 1,25(OH) 2 D 3 may prevent lung cancer progression in a molecularly defined subset of NSCLC patients
International Nuclear Information System (INIS)
Wan, Lingyu; Zhou, Yu; Liu, Liren; Sun, Jianfeng
2013-01-01
A free-space 2 × 4 90° optical hybrid with electro-optic modulation is presented. The hybrid principally consists of two pairs of electro-optic crystal plates coated with gold electrodes and a polarization analyzer. The optical hybrid uses the birefringence effect of a crystal to split and combine a signal beam and a local oscillator beam, uses the electro-optic effect to introduce a phase modulation and produce a phase shift, and outputs four-channel signal/local oscillator mixed beams whose phase difference can be adjusted continuously. A LiNbO 3 crystal is used to design and manufacture the space optical hybrid, and an experimental system is used to verify its performance. The results show that the output phase of the hybrid is continuously adjustable, enabling the hybrid to function perfectly as a 2 × 4 90° space optical hybrid under an appropriate electric field, and that the phase error can be compensated for by an electric field adjustment. (paper)
Energy Technology Data Exchange (ETDEWEB)
Ozaki, N.; Lappalainen, J.; Linnoila, M. [National Institute on Alcohol Abuse and Alcoholism, Rockville, MD (United States)] [and others
1995-04-24
Serotonin (5-HT){sub ID} receptors are 5-HT release-regulating autoreceptors in the human brain. Abnormalities in brain 5-HT function have been hypothesized in the pathophysiology of various psychiatric disorders, including obsessive-compulsive disorder, autism, mood disorders, eating disorders, impulsive violent behavior, and alcoholism. Thus, mutations occurring in 5-HT autoreceptors may cause or increase the vulnerability to any of these conditions. 5-HT{sub 1D{alpha}} and 5-HT{sub 1D{Beta}} subtypes have been previously localized to chromosomes 1p36.3-p34.3 and 6q13, respectively, using rodent-human hybrids and in situ localization. In this communication, we report the detection of a 5-HT{sub 1D{alpha}} receptor gene polymorphism by single strand conformation polymorphism (SSCP) analysis of the coding sequence. The polymorphism was used for fine scale linkage mapping of 5-HT{sub 1D{alpha}} on chromosome 1. This polymorphism should also be useful for linkage studies in populations and in families. Our analysis also demonstrates that functionally significant coding sequence variants of the 5-HT{sub 1D{alpha}} are probably not abundant either among alcoholics or in the general population. 14 refs., 1 fig., 1 tab.
CYP2R1 mutations causing vitamin D-deficiency rickets.
Thacher, Tom D; Levine, Michael A
2017-10-01
CYP2R1 is the principal hepatic 25-hydroxylase responsible for the hydroxylation of parent vitamin D to 25-hydroxyvitamin D [25(OH)D]. Serum concentrations of 25(OH)D reflect vitamin D status, because 25(OH)D is the major circulating metabolite of vitamin D. The 1α-hydroxylation of 25(OH)D in the kidney by CYP27B1 generates the fully active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH) 2 D). The human CYP2R1 gene, located at 11p15.2, has five exons, coding for an enzyme with 501 amino acids. In Cyp2r1-/- knockout mice, serum 25(OH)D levels were reduced by more than 50% compared wild-type mice. Genetic polymorphisms of CYP2R1 account for some of the individual variability of circulating 25(OH)D values in the population. We review the evidence that inactivating mutations in CYP2R1 can lead to a novel form of vitamin D-deficiency rickets resulting from impaired 25-hydroxylation of vitamin D. We sequenced the promoter, exons and intron-exon flanking regions of the CYP2R1 gene in members of 12 Nigerian families with rickets in more than one family member. We found missense mutations (L99P and K242N) in affected members of 2 of 12 families. The L99P mutation had previously been reported as a homozygous defect in an unrelated child of Nigerian origin with rickets. In silico analyses predicted impaired CYP2R1 folding or reduced interaction with substrate vitamin D by L99P and K242N mutations, respectively. In vitro studies of the mutant CYP2R1 proteins in HEK293 cells confirmed normal expression levels but completely absent or markedly reduced 25-hydroxylase activity by the L99P and K242N mutations, respectively. Heterozygous subjects had more moderate biochemical and clinical features of vitamin D deficiency than homozygous subjects. After an oral bolus dose of 50,000 IU of vitamin D 2 or vitamin D 3 , heterozygous subjects had lower increases in serum 25(OH)D than control subjects, and homozygous subjects had minimal increases, supporting a semidominant
Energy Technology Data Exchange (ETDEWEB)
Oria, M; Sorriaux, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires
1965-07-01
With a view to ease the work of research workers using 150 kV electrostatic accelerators, we have calculated the energy and the emission angle of particles emitted during the reactions {sub 1}{sup 3}T(d,n){sub 2}{sup 4}He, {sub 1}{sup 2}D(d,n){sub 2}{sup 3}He and {sub 1}{sup 2}D(d,p){sub 1}{sup 3}T. The results are classified in tables and arranged according to the acceleration energy of the deuterons. Since the energies considered are relatively low we have limited our study to the non-relativistic domain; this simplification results in a maximum energy variation with respect to the real energy values of 1 per cent. We give also two curves representing the variations in the total cross-sections for the reactions T (d,n){sub 2}{sup 4}He and D (d,n){sub 2}{sup 3}He. (authors) [French] De facon a faciliter la tache des experimentateurs utilisant des accelerateurs electrostatiques de 150 kV, nous avons calcule l'energie et l'angle d'emission des particules emises lors des reactions {sub 1}{sup 3}T(d,n){sub 2}{sup 4}He, {sub 1}{sup 2}D(d,n){sub 2}{sup 3}He and {sub 1}{sup 2}D(d,p){sub 1}{sup 3}T. Les resultats ont ete classes dans des tableaux, et ordonnes en fonction de l'energie d'acceleration des deuterons. Les energies considerees etant relativement peu elevees, nous avons limite notre etude au domaine non relativiste, cette simplification n'entraine qu'une variation maximale de 1 pour cent sur les valeurs reelles des energies. Nous avons joint a ce calcul deux courbes representant la variation des sections efficaces totales des reactions T (d,n){sub 2}{sup 4}He et D (d,n){sub 2}{sup 3}He. (auteurs)
Takanabe, Akifumi; Tanaka, Masahito; Taniguchi, Atsuo; Yamanaka, Hisashi; Asahi, Toru
2014-07-01
To improve our ability to identify single crystals causing arthritis, we have developed a practical measurement system of polarized light microscopy called advanced compensated polarized light microscopy (A-CPLM). The A-CPLM system is constructed by employing a conventional phase retardation plate, an optical fibre and a charge-coupled device spectrometer in a polarized light microscope. We applied the A-CPLM system to measure linear birefringence (LB) in the visible region, which is an optical anisotropic property, for tiny single crystals causing arthritis, i.e. monosodium urate monohydrate (MSUM) and calcium pyrophosphate dihydrate (CPPD). The A-CPLM system performance was evaluated by comparing the obtained experimental data using the A-CPLM system with (i) literature data for a standard sample, MgF2, and (ii) experimental data obtained using an established optical method, high-accuracy universal polarimeter, for the MSUM. The A-CPLM system was found to be applicable for measuring the LB spectra of the single crystals of MSUM and CPPD, which cause arthritis, in the visible regions. We quantitatively reveal the large difference in LB between MSUM and CPPD crystals. These results demonstrate the usefulness of the A-CPLM system for distinguishing the crystals causing arthritis.
Oral D-galactose supplementation in PGM1-CDG
Wong, S.Y.W.; Gadomski, T.; Scherpenzeel, M. van; Honzik, T.; Hansikova, H.; Holmefjord, K.S.B.; Mork, M.; Bowling, F.; Sykut-Cegielska, J.; Koch, D.; Hertecant, J.; Preston, G.; Jaeken, J.; Peeters, N.; Perez, S.; Nguyen, D.D.; Crivelly, K.; Emmerzaal, T.L.; Gibson, K.M.; Raymond, K.; Bakar, N. Abu; Foulquier, F.; Poschet, G.; Ackermann, A.M.; He, M.; Lefeber, D.J.; Thiel, C.; Kozicz, L.T.; Morava, E.
2017-01-01
PurposePhosphoglucomutase-1 deficiency is a subtype of congenital disorders of glycosylation (PGM1-CDG). Previous casereports in PGM1-CDG patients receiving oral D-galactose (D-gal) showed clinical improvement. So far no systematic in vitro and clinical studies have assessed safety and benefits of
1D Printing of Recyclable Robots
DEFF Research Database (Denmark)
Cellucci, Daniel; MacCurdy, Robert; Lipson, Hod
2017-01-01
Recent advances in 3D printing are revolutionizing manufacturing, enabling the fabrication of structures with unprecedented complexity and functionality. Yet biological systems are able to fabricate systems with far greater complexity using a process that involves assembling and folding a linear...... string. Here, we demonstrate a 1D printing system that uses an approach inspired by the ribosome to fabricate a variety of specialized robotic automata from a single string of source material. This proof-ofconcept system involves both a novel manufacturing platform that configures the source material...... using folding and a computational optimization tool that allows designs to be produced from the specification of high-level goals. We show that our 1D printing system is able to produce three distinct robots from the same source material, each of which is capable of accomplishing a specialized...
Differentiation-inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells
International Nuclear Information System (INIS)
Yasmin, Tania; Takahashi-Yanaga, Fumi; Mori, Jun; Miwa, Yoshikazu; Hirata, Masato; Watanabe, Yutaka; Morimoto, Sachio; Sasaguri, Toshiyuki
2005-01-01
To determine the mechanism by which differentiation-inducing factor-1 (DIF-1), a morphogen of Dictyostelium discoideum, inhibits tumor cell proliferation, we examined the effect of DIF-1 on the gene expression of cyclin D1. DIF-1 strongly reduced the expression of cyclin D1 mRNA and correspondingly decreased the amount of β-catenin in HeLa cells and squamous cell carcinoma cells. DIF-1 activated glycogen synthase kinase-3β (GSK-3β) and inhibition of GSK-3β attenuated the DIF-1-induced β-catenin degradation, indicating the involvement of GSK-3β in this effect. Moreover, DIF-1 reduced the activities of T-cell factor (TCF)/lymphoid enhancer factor (LEF) reporter plasmid and a reporter gene driven by the human cyclin D1 promoter. Eliminating the TCF/LEF consensus site from the cyclin D1 promoter diminished the effect of DIF-1. These results suggest that DIF-1 inhibits Wnt/β-catenin signaling, resulting in the suppression of cyclin D1 promoter activity
Role of the Caenorhabditis elegans multidrug resistance gene, mrp-4, in gut granule differentiation.
Currie, Erin; King, Brian; Lawrenson, Andrea L; Schroeder, Lena K; Kershner, Aaron M; Hermann, Greg J
2007-11-01
Caenorhabditis elegans gut granules are lysosome-related organelles with birefringent contents. mrp-4, which encodes an ATP-binding cassette (ABC) transporter homologous to mammalian multidrug resistance proteins, functions in the formation of gut granule birefringence. mrp-4(-) embryos show a delayed appearance of birefringent material in the gut granule but otherwise appear to form gut granules properly. mrp-4(+) activity is required for the extracellular mislocalization of birefringent material, body-length retraction, and NaCl sensitivity, phenotypes associated with defective gut granule biogenesis exhibited by embryos lacking the activity of GLO-1/Rab38, a putative GLO-1 guanine nucleotide exchange factor GLO-4, and the AP-3 complex. Multidrug resistance protein (MRP)-4 localizes to the gut granule membrane, consistent with it playing a direct role in the transport of molecules that compose and/or facilitate the formation of birefringent crystals within the gut granule. However, MRP-4 is also present in oocytes and early embryos, and our genetic analyses indicate that its site of action in the formation of birefringent material may not be limited to just the gut granule in embryos. In a search for genes that function similarly to mrp-4(+), we identified WHT-2, another ABC transporter that acts in parallel to MRP-4 for the formation of birefringent material in the gut granule.
Bogoliubov coefficients for the twist operator in the D1D5 CFT
Directory of Open Access Journals (Sweden)
Zaq Carson
2014-12-01
Full Text Available The D1D5 CFT is a holographic dual of a near-extremal black hole in string theory. The interaction in this theory involves a twist operator which joins together different copies of a free CFT. Given a large number of D1 and D5 branes, the effective length of the circle on which the CFT lives is very large. We develop a technique to study the effect of the twist operator in the limit where the wavelengths of excitations are short compared to this effective length, which we call the ‘continuum limit’. The method uses Bogoliubov coefficients to compute the effect of the twist operator in this limit. For bosonic fields, we use the method to reproduce recent results describing the effect of the twist operator when it links together CFT copies with windings M and N, producing a copy of winding M+N. We also comment on possible generalizations of our results. The methods developed here may help in understanding the twist interaction at higher orders. This in turn should provide insight into the thermalization process in the D1D5 CFT, which gives a holographic description of black hole formation.
Floodplain simulation for Musi River using integrated 1D/2D hydrodynamic model
Directory of Open Access Journals (Sweden)
Al Amin Muhammad B.
2017-01-01
Full Text Available This paper presents the simulation of floodplain at Musi River using integrated 1D and 2D hydrodynamic model. The 1D flow simulation was applied for the river channel with flow hydrograph as upstream boundary condition. The result of 1D flow simulation was integrated into 2D flow simulation in order to know the area and characteristics of flood inundation. The input data of digital terrain model which was used in this research had grid resolution of 10m×10m, but for 2D simulation the resolution was with grid resolution 50 m × 50 m so as to limit simulation time since the model size was big enough. The result of the simulation showed that the inundated area surrounding Musi River is about 107.44 km2 with maximum flood depth is 3.24 m, water surface velocity ranges from 0.00 to 0.83 m/s. Most of floodplain areas varied from middle to high flood hazard level, and only few areas had very high level of flood hazard especially on river side. The structural flood control measurement to be recommended to Palembang is to construct flood dike and flood gate. The non structural measurement one is to improve watershed management and socialization of flood awareness.
Simultaneous Multiple MS Binding Assays Addressing D1 and D2 Dopamine Receptors.
Schuller, Marion; Höfner, Georg; Wanner, Klaus T
2017-10-09
MS Binding Assays are a label-free alternative to radioligand binding assays. They provide basically the same capabilities as the latter, but use a non-labeled reporter ligand instead of a radioligand. In contrast to radioligand binding assays, MS Binding Assays offer-owing to the selectivity of mass spectrometric detection-the opportunity to monitor the binding of different reporter ligands at different targets simultaneously. The present study shows a proof of concept for this strategy as exemplified for MS Binding Assays selectively addressing D 1 and D 2 dopamine receptors in a single binding experiment. A highly sensitive, rapid and robust LC-ESI-MS/MS quantification method capable of quantifying both SCH23390 and raclopride, selectively addressing D 1 and D 2 receptors, respectively, was established and validated for this purpose. Based thereon, simultaneous saturation and competition experiments with SCH23390 and raclopride in the presence of both D 1 and D 2 receptors were performed and analyzed by LC-MS/MS within a single chromatographic cycle. The present study thus demonstrates the feasibility of this strategy and the high versatility of MS Binding Assays that appears to surpass that common for conventional radioligand binding assays. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Hepatitis B virus subgenotypes D1 and D3 are prevalent in Pakistan
Directory of Open Access Journals (Sweden)
Chakravarty Runu
2009-01-01
Full Text Available Abstract Background As the hepatitis B genotyping is important for assessing its clinical implications and geographical distribution, the sub-genotypes have been found useful for determination of specific genomic markers related to hepatocarcinogenesis. In Pakistan, there is no reported data on molecular evolutionary analysis of HBV. A study was, therefore, much needed to evaluate the spectra of mutations present in the strains prevalent here. Findings to confirm specificity of PCR typing, phylogenetic analysis of the pre-S1 region and the divergence was studied through 13 sequences of 362 bp (accession number EF432765 – EF432777. A total of 315 serum samples, selected from HBsAg positive patients representing the major ethnic groups, residing in Karachi, Sindh were tested for genotyping. Genotype D (219/315 was found to be the most prevalent (70% amongst our patients. The rest of the genotypes A and a mixture of A and D (AD were distributed as 20%, and 10% respectively. Phylogenetic tree demonstrated clustering of 11 samples with subgenotype D1 sequences and the remaining two strains on a branch within D3 samples. All samples intermixed with strains from other countries and were found to be closely related to Indian, Iranian and Egyptian HBV strains with 98.7 – 99.0% homology. Conclusion This study confirms the predominance of genotype D in southeastern Asia and presence of subgenotypes DI and D3 in the Pakistani infected patients. More studies are required to investigate the reason for fewer inclusions of D3 compared to the D1 in Pakistani HBV strains.
(1S-1,2-O-Benzylidene-α-d-glucurono-6,3-lactone
Directory of Open Access Journals (Sweden)
David J. Watkin
2009-02-01
Full Text Available X-ray crystallographic analysis has established that the major product from the protection of d-glucoronolactone with benzaldehyde is (1S-1,2-O-benzylidene-α-d-glucurono-6,3-lactone, C13H12O6, rather than the R epimer. The crystal structure exists as O—H...O hydrogen-bonded chains of molecules lying parallel to the a axis. The absolute configuration was determined by the use of d-glucuronolactone as the starting material.
Using one hybrid 3D-1D-3D approach for the conceptual design of WCCB blanket for CFETR
Energy Technology Data Exchange (ETDEWEB)
Jiang, Kecheng; Zhang, Xiaokang [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); University of Science and Technology of China, Hefei, Anhui, 230027 (China); Li, Jia [University of Science and Technology of China, Hefei, Anhui, 230027 (China); Ma, Xuebin [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); University of Science and Technology of China, Hefei, Anhui, 230027 (China); Liu, Songlin, E-mail: slliu@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); University of Science and Technology of China, Hefei, Anhui, 230027 (China)
2017-01-15
Highlights: • The Hybrid 3D-1D-3D approach is used for radial building design of WCCB. • Nuclear heat obtained by this method agrees well with 3D neutronics results. • The final results of temperature and TBR satisfy with the requirements. • All the results show that this approach is high efficiency and high reliability. - Abstract: A hybrid 3D-1D-3D approach is proposed for the conceptual design of a blanket. Firstly, the neutron wall loading (NWL) of each blanket module is obtained through a neutronics calculation employing a 3D model, which contains the geometry outline of in-vacuum vessel components and the exact neutron source distribution. Secondly, a 1D cylindrical model with the blanket module containing a detailed radial building is adopted for the neutronics analysis, with the aim of calculating the tritium breeding ratio (TBR) and nuclear heating. Being normalized to the NWL, the nuclear heating is transferred to a 2D model for thermal-hydraulics analysis using the FLUENT code. Through a series analysis of nuclear-thermal iterations that considers the tritium breeding ratio (TBR) and thermal performance as optimization objectives, the optimized radial building of each module surrounding plasma can be obtained. Thirdly, the 3D structural design of each module is established by adding side walls, cover plates, stiffening plates, and other components based on the radial building. The 3D neutronics and thermal-hydraulics using the detailed blanket modules are re-analyzed. This approach has been successfully applied to the design of a water-cooled ceramic breeder blanket for the Chinese Fusion Engineering Test Reactor (CFETR). The radial building of each blanket module surrounding plasma is optimized. The global tritium breeding ratio (TBR) calculated by the 3D neutronics analysis is 1.21, and the temperature of all materials in the 3D blanket structure is below the upper limits. As indicated by the comparison of the 1D and 3D neutronics and thermal
1985-05-30
data in terms of the damage frequency was made and compared to theoretical damage probability distributions from a degenerate defect ensemble model...diaseases affecting the macula . The polarized-light retinal pattern is attributed to birefringence in cone-photoreceptor outer segments. Haidinger’s
Biedron, Robert T.; Carlson, Jan-Renee; Derlaga, Joseph M.; Gnoffo, Peter A.; Hammond, Dana P.; Jones, William T.; Kleb, Bil; Lee-Rausch, Elizabeth M.; Nielsen, Eric J.; Park, Michael A.;
2017-01-01
This manual describes the installation and execution of FUN3D version 13.1, including optional dependent packages. FUN3D is a suite of computational fluid dynamics simulation and design tools that uses mixed-element unstructured grids in a large number of formats, including structured multiblock and overset grid systems. A discretely-exact adjoint solver enables efficient gradient-based design and grid adaptation to reduce estimated discretization error. FUN3D is available with and without a reacting, real-gas capability. This generic gas option is available only for those persons that qualify for its beta release status.
Subrahmanyam, Priyanka B; Carey, Gregory B; Webb, Tonya J
2014-09-01
NKT cells are a unique subset of T cells that recognize glycolipid Ags presented in the context of CD1d molecules. NKT cells mount strong antitumor responses and are a major focus in developing effective cancer immunotherapy. It is known that CD1d molecules are constantly internalized from the cell surface, recycled through the endocytic compartments, and re-expressed on the cell surface. However, little is known about the regulation of CD1d-mediated Ag processing and presentation in B cell lymphoma. Prosurvival factors of the Bcl-2 family, such as Bcl-xL, are often upregulated in B cell lymphomas and are intimately linked to sphingolipid metabolism, as well as the endocytic compartments. We hypothesized that Bcl-xL can regulate CD1d-mediated Ag presentation to NKT cells. We found that overexpression or induction of Bcl-xL led to increased Ag presentation to NKT cells. Conversely, the inhibition or knockdown of Bcl-xL led to decreased NKT cell activation. Furthermore, knockdown of Bcl-xL resulted in the loss of CD1d trafficking to lysosome-associated membrane protein 1(+) compartments. Rab7, a late endosomal protein, was upregulated and CD1d molecules accumulated in the Rab7(+) late endosomal compartment. These results demonstrate that Bcl-xL regulates CD1d-mediated Ag processing and presentation to NKT cells by altering the late endosomal compartment and changing the intracellular localization of CD1d. Copyright © 2014 by The American Association of Immunologists, Inc.
Guitart, Xavier; Navarro, Gemma; Moreno, Estefania; Yano, Hideaki; Cai, Ning-Sheng; Sánchez-Soto, Marta; Kumar-Barodia, Sandeep; Naidu, Yamini T; Mallol, Josefa; Cortés, Antoni; Lluís, Carme; Canela, Enric I; Casadó, Vicent; McCormick, Peter J; Ferré, Sergi
2014-10-01
The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies suggested that this heteromer could be involved in the ability of D3R agonists to potentiate locomotor activation induced by D1R agonists. It has also been postulated that its overexpression plays a role in L-dopa-induced dyskinesia and in drug addiction. However, little is known about its biochemical properties. By combining bioluminescence resonance energy transfer, bimolecular complementation techniques, and cell-signaling experiments in transfected cells, evidence was obtained for a tetrameric stoichiometry of the D1R-D3R heteromer, constituted by two interacting D1R and D3R homodimers coupled to Gs and Gi proteins, respectively. Coactivation of both receptors led to the canonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of β-arrestin-1, and to a positive cross talk of D1R and D3R agonists at the level of mitogen-activated protein kinase (MAPK) signaling. Furthermore, D1R or D3R antagonists counteracted β-arrestin-1 recruitment and MAPK activation induced by D3R and D1R agonists, respectively (cross-antagonism). Positive cross talk and cross-antagonism at the MAPK level were counteracted by specific synthetic peptides with amino acid sequences corresponding to D1R transmembrane (TM) domains TM5 and TM6, which also selectively modified the quaternary structure of the D1R-D3R heteromer, as demonstrated by complementation of hemiproteins of yellow fluorescence protein fused to D1R and D3R. These results demonstrate functional selectivity of allosteric modulations within the D1R-D3R heteromer, which can be involved with the reported behavioral synergism of D1R and D3R agonists. U.S. Government work not protected by U.S. copyright.
Guitart, Xavier; Navarro, Gemma; Moreno, Estefania; Yano, Hideaki; Cai, Ning-Sheng; Sánchez-Soto, Marta; Kumar-Barodia, Sandeep; Naidu, Yamini T.; Mallol, Josefa; Cortés, Antoni; Lluís, Carme; Canela, Enric I.; Casadó, Vicent; McCormick, Peter J.
2014-01-01
The dopamine D1 receptor–D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies suggested that this heteromer could be involved in the ability of D3R agonists to potentiate locomotor activation induced by D1R agonists. It has also been postulated that its overexpression plays a role in L-dopa–induced dyskinesia and in drug addiction. However, little is known about its biochemical properties. By combining bioluminescence resonance energy transfer, bimolecular complementation techniques, and cell-signaling experiments in transfected cells, evidence was obtained for a tetrameric stoichiometry of the D1R–D3R heteromer, constituted by two interacting D1R and D3R homodimers coupled to Gs and Gi proteins, respectively. Coactivation of both receptors led to the canonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of β-arrestin-1, and to a positive cross talk of D1R and D3R agonists at the level of mitogen-activated protein kinase (MAPK) signaling. Furthermore, D1R or D3R antagonists counteracted β-arrestin-1 recruitment and MAPK activation induced by D3R and D1R agonists, respectively (cross-antagonism). Positive cross talk and cross-antagonism at the MAPK level were counteracted by specific synthetic peptides with amino acid sequences corresponding to D1R transmembrane (TM) domains TM5 and TM6, which also selectively modified the quaternary structure of the D1R-D3R heteromer, as demonstrated by complementation of hemiproteins of yellow fluorescence protein fused to D1R and D3R. These results demonstrate functional selectivity of allosteric modulations within the D1R-D3R heteromer, which can be involved with the reported behavioral synergism of D1R and D3R agonists. PMID:25097189
17 CFR 240.15c3-1d - Satisfactory Subordination Agreements (Appendix D to 17 CFR 240.15c3-1).
2010-04-01
... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Satisfactory Subordination...-Counter Markets § 240.15c3-1d Satisfactory Subordination Agreements (Appendix D to 17 CFR 240.15c3-1). (a) Introduction. (1) This Appendix sets forth minimum and non-exclusive requirements for satisfactory...
Viana, Adriano G; Noseda, Miguel D; Gonçalves, Alan G; Duarte, Maria Eugênia R; Yokoya, Nair; Matulewicz, Maria C; Cerezo, Alberto S
2011-06-01
Xylans from five seaweeds belonging to the order Nemaliales (Galaxaura marginata, Galaxaura obtusata, Tricleocarpacylindrica, Tricleocarpa fragilis, and Scinaia halliae) and one of the order Palmariales (Palmaria palmata) collected on the Brazilian coasts were extracted with hot water and purified from acid xylomannans and/or xylogalactans through Cetavlon precipitation of the acid polysaccharides. The β-D-(1→4), β-D-(1→3) 'mixed linkage' structures were determined using methylation analysis and 1D and 2D NMR spectroscopy. The presence of large sequences of β-(1→4)-linked units suggests transient aggregates of ribbon- or helical-ordered structures that would explain the low optical rotations. Copyright © 2011 Elsevier Ltd. All rights reserved.
26 CFR 1.415(d)-1 - Cost-of-living adjustments.
2010-04-01
...)(A) dollar limitation pursuant to section 611(a)(1)(A) of the Economic Growth and Tax Relief... adjustments. (a) Defined benefit plans—(1) Dollar limitation—(i) Determination of adjusted limit. Under section 415(d)(1)(A), the dollar limitation described in section 415(b)(1)(A) applicable to defined...
D1/D5 system with B-field, noncommutative geometry and the CFT of the higgs branch
Dhar, A; Wadia, S R; Yogendran, K P; Dhar, Avinash; Mandal, Gautam; Wadia, Spenta R.
2000-01-01
The D1/D5 system is considered in the presence of the NS B field. An explicit supergravity solution in the asymptotically flat and near horizon limits is presented. Explicit mass formulae are presented in both cases. This solution has no D3 source branes and represents a true bound state of the D1/D5 system. We study the motion of a separated D1-brane in the background geometry described above and reproduce the Liouville potential that binds the D1 brane. A gauge theory analysis is also presented in the presence of Fayet-Iliopoulos (FI) parameters which can be identified with the self-dual part of the NS B field. In the case of a single D5-brane and an arbitrary number of D1 branes we can demonstrate the existence of a bound state in the Higgs branch. We also point out the connection of the SCFT on the resolved Sym$_{Q_1Q_5}(\\tilde T^4)$ with recent developments in non-commutative Yang-Mills theory.
The pathophysiological functions mediated by D-1 dopamine receptors
International Nuclear Information System (INIS)
Goldstein, M.; Kuga, S.; Meller, E.; SHimizu, Y.
1986-01-01
This chapter describes some behavioral responses which might be mediated by D 1 and D 2 DA receptors, and the authors discuss their clinical relevance. It was of considerable interest to determine whether a selective D 1 DA antagonist, such as SCH 23390, will induce catalepsy and whether this behavior is mediated by D 1 , or by both D 1 and D 2 DA receptors. Rats were used in the experiments. The authors examined whether the addition of the S 2 antagonist ketanserin affects the displacement of 3 H-Spi by SCH 23390. Induction of self-mutilating biting (SMB) behavior in monkeys with unilateral ventromedial tegmental (VMT) lesions by DA agonists and its prevention by DA antagonists is examined. The authors also discuss the possible relationships between abnormal guanine nucleotide metabolism and dopaminergic neuronal function through the implications in LeschNyhan syndrome and in some mental disorders
The Implications of 3D Thermal Structure on 1D Atmospheric Retrieval
Energy Technology Data Exchange (ETDEWEB)
Blecic, Jasmina; Dobbs-Dixon, Ian [NYU Abu Dhabi, Abu Dhabi (United Arab Emirates); Greene, Thomas, E-mail: jasmina@nyu.edu [NASA Ames Research Center, Space Sciece and Astrobiology Division, M.S. 245-6, Moffett Field, CA 94035 (United States)
2017-10-20
Using the atmospheric structure from a 3D global radiation-hydrodynamic simulation of HD 189733b and the open-source Bayesian Atmospheric Radiative Transfer (BART) code, we investigate the difference between the secondary-eclipse temperature structure produced with a 3D simulation and the best-fit 1D retrieved model. Synthetic data are generated by integrating the 3D models over the Spitzer , the Hubble Space Telescope ( HST ), and the James Web Space Telescope ( JWST ) bandpasses, covering the wavelength range between 1 and 11 μ m where most spectroscopically active species have pronounced features. Using the data from different observing instruments, we present detailed comparisons between the temperature–pressure profiles recovered by BART and those from the 3D simulations. We calculate several averages of the 3D thermal structure and explore which particular thermal profile matches the retrieved temperature structure. We implement two temperature parameterizations that are commonly used in retrieval to investigate different thermal profile shapes. To assess which part of the thermal structure is best constrained by the data, we generate contribution functions for our theoretical model and each of our retrieved models. Our conclusions are strongly affected by the spectral resolution of the instruments included, their wavelength coverage, and the number of data points combined. We also see some limitations in each of the temperature parametrizations, as they are not able to fully match the complex curvatures that are usually produced in hydrodynamic simulations. The results show that our 1D retrieval is recovering a temperature and pressure profile that most closely matches the arithmetic average of the 3D thermal structure. When we use a higher resolution, more data points, and a parametrized temperature profile that allows more flexibility in the middle part of the atmosphere, we find a better match between the retrieved temperature and pressure profile and
The Implications of 3D Thermal Structure on 1D Atmospheric Retrieval
Blecic, Jasmina; Dobbs-Dixon, Ian; Greene, Thomas
2017-10-01
Using the atmospheric structure from a 3D global radiation-hydrodynamic simulation of HD 189733b and the open-source Bayesian Atmospheric Radiative Transfer (BART) code, we investigate the difference between the secondary-eclipse temperature structure produced with a 3D simulation and the best-fit 1D retrieved model. Synthetic data are generated by integrating the 3D models over the Spitzer, the Hubble Space Telescope (HST), and the James Web Space Telescope (JWST) bandpasses, covering the wavelength range between 1 and 11 μm where most spectroscopically active species have pronounced features. Using the data from different observing instruments, we present detailed comparisons between the temperature-pressure profiles recovered by BART and those from the 3D simulations. We calculate several averages of the 3D thermal structure and explore which particular thermal profile matches the retrieved temperature structure. We implement two temperature parameterizations that are commonly used in retrieval to investigate different thermal profile shapes. To assess which part of the thermal structure is best constrained by the data, we generate contribution functions for our theoretical model and each of our retrieved models. Our conclusions are strongly affected by the spectral resolution of the instruments included, their wavelength coverage, and the number of data points combined. We also see some limitations in each of the temperature parametrizations, as they are not able to fully match the complex curvatures that are usually produced in hydrodynamic simulations. The results show that our 1D retrieval is recovering a temperature and pressure profile that most closely matches the arithmetic average of the 3D thermal structure. When we use a higher resolution, more data points, and a parametrized temperature profile that allows more flexibility in the middle part of the atmosphere, we find a better match between the retrieved temperature and pressure profile and the
Gross, Noah B; Duncker, Patrick C; Marshall, John F
2011-11-01
Methamphetamine (mAMPH) is an addictive psychostimulant drug that releases monoamines through nonexocytotic mechanisms. In animals, binge mAMPH dosing regimens deplete markers for monoamine nerve terminals, for example, dopamine and serotonin transporters (DAT and SERT), in striatum and cerebral cortex. Although the precise mechanism of mAMPH-induced damage to monoaminergic nerve terminals is uncertain, both dopamine D1 and D2 receptors are known to be important. Systemic administration of dopamine D1 or D2 receptor antagonists to rodents prevents mAMPH-induced damage to striatal dopamine nerve terminals. Because these studies employed systemic antagonist administration, the specific brain regions involved remain to be elucidated. The present study examined the contribution of dopamine D1 and D2 receptors in striatum to mAMPH-induced DAT and SERT neurotoxicities. In this experiment, either the dopamine D1 antagonist, SCH23390, or the dopamine D2 receptor antagonist, sulpiride, was intrastriatally infused during a binge mAMPH regimen. Striatal DAT and cortical, hippocampal, and amygdalar SERT were assessed as markers of mAMPH-induced neurotoxicity 1 week following binge mAMPH administration. Blockade of striatal dopamine D1 or D2 receptors during an otherwise neurotoxic binge mAMPH regimen produced widespread protection against mAMPH-induced striatal DAT loss and cortical, hippocampal, and amygdalar SERT loss. This study demonstrates that (1) dopamine D1 and D2 receptors in striatum, like nigral D1 receptors, are needed for mAMPH-induced striatal DAT reductions, (2) these same receptors are needed for mAMPH-induced SERT loss, and (3) these widespread influences of striatal dopamine receptor antagonists are likely attributable to circuits connecting basal ganglia to thalamus and cortex. Copyright © 2011 Wiley-Liss, Inc.
26 CFR 1.167(d)-1 - Agreement as to useful life and rates of depreciation.
2010-04-01
... depreciation. 1.167(d)-1 Section 1.167(d)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(d)-1 Agreement as to useful life and rates of depreciation. After August 16... respect to the estimated useful life, method and rate of depreciation and treatment of salvage of any...
André, Marion Agnès Emma; Manahan-Vaughan, Denise
2015-01-01
Dopamine contributes to the regulation of higher order information processing and executive control. It is important for memory consolidation processes, and for the adaptation of learned responses based on experience. In line with this, under aversive learning conditions, application of dopamine receptor antagonists prior to extinction result in enhanced memory reinstatement. Here, we investigated the contribution of the dopaminergic system to extinction and memory reinstatement (renewal) of an appetitive spatial learning task in rodents. Rats were trained for 3 days in a T-maze (context "A") to associate a goal arm with a food reward, despite low reward probability (acquisition phase). On day 4, extinction learning (unrewarded) occurred, that was reinforced by a context change ("B"). On day 5, re-exposure to the (unrewarded) "A" context took place (renewal of context "A", followed by extinction of context "A"). In control animals, significant extinction occurred on day 4, that was followed by an initial memory reinstatement (renewal) on day 5, that was, in turn, succeeded by extinction of renewal. Intracerebral treatment with a D1/D5-receptor antagonist prior to the extinction trials, elicited a potent enhancement of extinction in context "B". By contrast, a D1/D5-agonist impaired renewal in context "A". Extinction in the "A" context on day 5 was unaffected by the D1/D5-ligands. Treatment with a D2-receptor antagonist prior to extinction had no overall effect on extinction in context "B" or renewal in context "A", although extinction of the renewal effect was impaired on day 5, compared to controls. Taken together, these data suggest that dopamine acting on the D1/D5-receptor modulates both acquisition and consolidation of context-dependent extinction. By contrast, the D2-receptor may contribute to context-independent aspects of this kind of extinction learning.
Numerical simulation of Ge solar cells using D-AMPS-1D code
Energy Technology Data Exchange (ETDEWEB)
Barrera, Marcela, E-mail: barrera@tandar.cnea.gov.ar [Comision Nacional de Energia Atomica, Avenida General Paz 1499, San Martin 1650, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Argentina); Rubinelli, Francisco [Instituto de Desarrollo Tecnologico para la Industria Quimica (INTEC)-CONICET, Gueemes 3450, Santa Fe 3000 (Argentina); Rey-Stolle, Ignacio [Instituto de Energia Solar, Universidad Politecnica de Madrid, Avenida Complutense 30, Madrid 28040 (Spain); Pla, Juan [Comision Nacional de Energia Atomica, Avenida General Paz 1499, San Martin 1650, Buenos Aires (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Argentina)
2012-08-15
A solar cell is a solid state device that converts the energy of sunlight directly into electricity by the photovoltaic effect. When light with photon energies greater than the band gap is absorbed by a semiconductor material, free electrons and free holes are generated by optical excitation in the material. The main characteristic of a photovoltaic device is the presence of internal electric field able to separate the free electrons and holes so they can pass out of the material to the external circuit before they recombine. Numerical simulation of photovoltaic devices plays a crucial role in their design, performance prediction, and comprehension of the fundamental phenomena ruling their operation. The electrical transport and the optical behavior of the solar cells discussed in this work were studied with the simulation code D-AMPS-1D. This software is an updated version of the one-dimensional (1D) simulation program Analysis of Microelectronic and Photonic Devices (AMPS) that was initially developed at The Penn State University, USA. Structures such as homojunctions, heterojunctions, multijunctions, etc., resulting from stacking layers of different materials can be studied by appropriately selecting characteristic parameters. In this work, examples of cells simulation made with D-AMPS-1D are shown. Particularly, results of Ge photovoltaic devices are presented. The role of the InGaP buffer on the device was studied. Moreover, a comparison of the simulated electrical parameters with experimental results was performed.
Numerical simulation of Ge solar cells using D-AMPS-1D code
International Nuclear Information System (INIS)
Barrera, Marcela; Rubinelli, Francisco; Rey-Stolle, Ignacio; Plá, Juan
2012-01-01
A solar cell is a solid state device that converts the energy of sunlight directly into electricity by the photovoltaic effect. When light with photon energies greater than the band gap is absorbed by a semiconductor material, free electrons and free holes are generated by optical excitation in the material. The main characteristic of a photovoltaic device is the presence of internal electric field able to separate the free electrons and holes so they can pass out of the material to the external circuit before they recombine. Numerical simulation of photovoltaic devices plays a crucial role in their design, performance prediction, and comprehension of the fundamental phenomena ruling their operation. The electrical transport and the optical behavior of the solar cells discussed in this work were studied with the simulation code D-AMPS-1D. This software is an updated version of the one-dimensional (1D) simulation program Analysis of Microelectronic and Photonic Devices (AMPS) that was initially developed at The Penn State University, USA. Structures such as homojunctions, heterojunctions, multijunctions, etc., resulting from stacking layers of different materials can be studied by appropriately selecting characteristic parameters. In this work, examples of cells simulation made with D-AMPS-1D are shown. Particularly, results of Ge photovoltaic devices are presented. The role of the InGaP buffer on the device was studied. Moreover, a comparison of the simulated electrical parameters with experimental results was performed.
Sampling and analysis plan for Mount Plant D ampersand D soils packages, Revision 1
International Nuclear Information System (INIS)
1991-02-01
There are currently 682 containers of soils in storage at Mound Plant, generated between April 1 and October 31, 1990 as a result of excavation of soils containing plutonium-238 at two ongoing Decontamination and Decommissioning (D ampersand D) Program sites. These areas are known as Area 14, the waste transfer system (WTS) hillside, and Area 17, the Special Metallurgical (SM) Building area. The soils from these areas are part of Mound Plant waste stream number AMDM-000000010, Contaminated Soil, and are proposed for shipment to the Nevada Test Site (NTS) for disposal as low-level radioactive waste. The sealed waste packages, constructed of either wood or metal, are currently being stored in Building 31 and at other locations throughout the Mound facility. At a meeting in Las Vegas, Nevada on October, 26, 1990, DOE Nevada Operations Office (DOE-NV) and NTS representatives requested that the Mound Plant D ampersand D soils proposed for shipment to NTS be sampled for Toxicity Characteristic Leaching Procedure (TCLP) constituents. On December 14, 1990, DOE-NV also requested that additional analyses be performed on the soils from one of the soils boxes for polychlorinated biphenyls (PCBs), particle size distribution, and free liquids. The purpose of this plan is to document the proposed sampling and analyses of the packages of D ampersand D soils produced prior to October 31, 1990. In order to provide a thorough description of the soils excavated from the WTS and SM areas, sections 1.1 and 1.2 provide historical Information concerning the D ampersand D soils, including waste stream evaluations and past sampling data
The development of 99mTc-d, 1-HM-PAO
International Nuclear Information System (INIS)
Bai Lanqin; Huang Jinjie; Fan Li; Bai Suzhen; Li Guoli; Jing Hui; Xiao Lun
1991-12-01
The 99m Tc-d,1-HM-PAO is an ideal radiopharmaceutical for regional cerebral blood perfusion imaging. The improvement of synthesis and separation of diastereoisomers leads to obtain high purity (>99%) of d, 1-HM-PAO and meso-HM-PAO. During separation H NMR spectroscopy was used to monitor the relative composition of these two diastereoisomers that can ensure the purity of pligand of d,1-HM-PAO. The intravenous injection of 99m Tc-d,1-HM-PAO was formed by adding fresh 99m Tc washing liquor into a sterile. Pyrogen-free and freeze-dried vial. The radiochemical purity (RCP) of 99m Tc-d,1-HM-PAO was greater than 80%. From the experiments of 99m Tc-d,1-HM-PAO in mice, after two minutes of intravenously (I>V>) administration about 2.24% of injected dose (I.D.)appeared in the brain, and after 24 hours about 72% of radioactivity of injected dose still left in the brain. But for the 99m Tc-meso-HM-PAO after two minutes of i.v. administration, about 1.93% of I.D. appeared in the brain, and 24 hours later, 25% of radioactivity of I.D. was in the brain. This result shows that in the brain the radioactivity of 99m Tc-meso-HM-PAO declines faster than that of 99m Td-d,1-HM-PAO
Ghostine, Rabih; Hoteit, Ibrahim; Vazquez, Jose; Terfous, Abdelali; Ghenaim, Abdellah; Mose, Robert
2014-01-01
In open channel networks, flow is usually approximated by the one-dimensional (1D) Saint-Venant equations coupled with an empirical junction model. In this work, a comparison in terms of accuracy and computational cost between a coupled 1D-2D
The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism
DEFF Research Database (Denmark)
Szekeres, Ferenc; Chadt, Alexandra; Tom, Robby Z
2012-01-01
The Rab-GTPase-activating protein TBC1D1 has emerged as a novel candidate involved in metabolic regulation. Our aim was to determine whether TBC1D1 is involved in insulin as well as energy-sensing signals controlling skeletal muscle metabolism. TBC1D1-deficient congenic B6.SJL-Nob1.10 (Nob1.10(SJL...... be explained partly by a 50% reduction in GLUT4 protein, since proximal signaling at the level of Akt, AMPK, and acetyl-CoA carboxylase (ACC) was unaltered. Paradoxically, in vivo insulin-stimulated 2-deoxyglucose uptake was increased in EDL and tibialis anterior muscle from TBC1D1-deficient mice......)) and wild-type littermates were studied. Glucose and insulin tolerance, glucose utilization, hepatic glucose production, and tissue-specific insulin-mediated glucose uptake were determined. The effect of insulin, AICAR, or contraction on glucose transport was studied in isolated skeletal muscle. Glucose...
The D1-D2 region of the large subunit ribosomal DNA as barcode for ciliates.
Stoeck, T; Przybos, E; Dunthorn, M
2014-05-01
Ciliates are a major evolutionary lineage within the alveolates, which are distributed in nearly all habitats on our planet and are an essential component for ecosystem function, processes and stability. Accurate identification of these unicellular eukaryotes through, for example, microscopy or mating type reactions is reserved to few specialists. To satisfy the demand for a DNA barcode for ciliates, which meets the standard criteria for DNA barcodes defined by the Consortium for the Barcode of Life (CBOL), we here evaluated the D1-D2 region of the ribosomal DNA large subunit (LSU-rDNA). Primer universality for the phylum Ciliophora was tested in silico with available database sequences as well as in the laboratory with 73 ciliate species, which represented nine of 12 ciliate classes. Primers tested in this study were successful for all tested classes. To test the ability of the D1-D2 region to resolve conspecific and congeneric sequence divergence, 63 Paramecium strains were sampled from 24 mating species. The average conspecific D1-D2 variation was 0.18%, whereas congeneric sequence divergence averaged 4.83%. In pairwise genetic distance analyses, we identified a D1-D2 sequence divergence of DNA amplification of single cells and voucher deposition. In conclusion, the presented data pinpoint the D1-D2 region as an excellent candidate for an official CBOL barcode for ciliated protists. © 2013 John Wiley & Sons Ltd.
Galaj, Ewa; Ewing, Scott; Ranaldi, Robert
2018-06-01
In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting dopamine D1 or D3 receptors because of the involvement of these receptors in drug-related behaviors. D1-like and D3 receptor partial agonists and antagonists have been shown to reduce drug reward, reinstatement of drug seeking and conditioned place preference in rodents and non-human primates. However, translation of these encouraging results to clinical settings has been limited due to a number of factors including toxicity, poor pharmacokinetic properties and extrapyramidal and sedative side effects. This review highlights the role of D1 and D3 receptors in drug reward and seeking, the discovery of D1-D3 heteromers and their potential as targets in the treatment of addiction. Copyright © 2018 Elsevier Ltd. All rights reserved.
The influence of pressure on the birefringence in semiconductor compounds ZnS, CuGaS2, and InPS4
International Nuclear Information System (INIS)
Lavrentyev, A.A.; Gabrelian, B.V.; Kulagin, B.B.; Nikiforov, I.Ya.; Sobolev, V.V.
2007-01-01
Using the modified method of augmented plane waves and the code WIEN2k the calculations of the electron band structure, densities of electron states, and imaginary part of dielectric response function were carried out for different polarization of the vector of electrical field ε xx and ε zz for the semiconductor compounds ZnS, CuGaS 2 , and InPS 4 . The calculations were performed both for undisturbed crystals and for distorted crystals due to the applied pressure. The compounds studied have the similar crystallographic structures: ZnS - sphalerite, CuGaS 2 - chalcopyrite, and InPS 4 - twice defective chalcopyrite. It is known, that in cubic ZnS there is no birefringence, whereas in CuGaS 2 and InPS 4 there is one. But CuGaS 2 has so called isotropic point (where ε xx =ε zz ) in the visible optical range, and InPS 4 has no such point. Our calculations of ε xx and ε zz have shown that in ZnS under the pressure the isotropic points arise, but in InPS 4 they do not exist. (copyright 2007 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)
Measurement of circulating 1,25-dihydroxyvitamin D employing radioimmunoassay
International Nuclear Information System (INIS)
Yamamoto, Itsuo; Hamazu, Hisatoshi; Kigami, Yuusuke; Morita, Rikushi
1997-01-01
Measurement of serum 1,25-dihydroxyvitamin D levels is important for diagnosis of various calcium metabolism disorders. Conventional assays for 1,25-dihydroxyvitamin D employed specific 1,25-dihydroxyvitamin D receptor as binding site for the ligand and thus, biologically active 1,25-dihydroxyvitamin D ligand, which is labeled with 3 H, was required. Usage of 3 H made assays cumbersome works. A new assay which uses specific antibody as the binding site and the radioligand labeled with 125 I is now available as a commercial kit. Using these kits, we first studied basically the reproducibility, recovery, cross-reactivity and comparison with conventional assays. All of those results were satisfactory. Secondly, we measured clinically in 111 healthy adults and in patients with various disorders such as renal failure, primary hyperparathyroidism, hypoparathyroidism and sarcoidosis. This newly available kit for measurement of circulating 1,25-dihydroxyvitamin D is proved to be useful in clinical evaluation of calcium metabolic disorders. (author)
Far-Infrared Magneto-Optical Studies in Germanium and Indium-Antimonide at High Intensities
Leung, Michael
Observations of nonlinear magneto-optical phenomena occurring in p-type Germanium and n-type Indium Antimonide are reported. These include multi-photon ionization of impurity states, and a new observation, the magneto-photon ionization of impurity states, and a new observation, the magneto-photon drag effect. A novel source of far-infrared radiation has been used. This source uses a pulsed CO(,2) LASER to optically pump a super-radiant cell, generating light with intensities up to 100 KW/cm('2) and wavelengths from 66 (mu)m to 496 (mu)m in a pulse of 150 nanoseconds duration. The Germanium samples were doped with Gallium, which is a shallow acceptor with an ionization potential of 11 meV. At liquid Helium temperature virtually all charge carriers are bound to acceptor sites. However, the high intensity radiation unexpectedly ionizes the acceptors. This is demonstrated through measurements of photoconductivity, transmission and the photo-Hall Effect. This observation is unexpected because the photon energy is one-fourth the ionization potential. Rate equations describing sequential multiphoton excitations are in agreement with the experimental results. The intermediate states are postulated to be acceptor exciton band states. Studies of the photoexcited mobility at 496 (mu)m suggest that at non-saturating levels of photoexcitation, the primary scattering mechanism of hot holes in Germanium is by neutral impurities. A new magneto-optical effect, the magneto-photon drag effect, has been studied in both Germanium and Indium Antimonide. This is simply the absorption of momentum by free carriers, from an incident photon field. It has been found that the mechanism for this effect is different in the two materials. In Germanium, the effect occurs when carriers make optical transitions from the heavy hole band to the light hole band. Thus, the magneto-optical behavior depends heavily upon the band structure. On the other hand, a modified Drude model (independent electron
Energy Technology Data Exchange (ETDEWEB)
K. L. Vialetti
2008-05-20
This report presents the final hazard categorization for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site.
International Nuclear Information System (INIS)
Creighton, W.J.
1991-01-01
This paper reports on the 90 mm EMGWS D1 Projectile which is an unguided projectile that is designed for launch from an Electromagnetic gun to achieve significant armor penetration. It is being developed under the broader program called Electromagnetic Gun Weapon System (EMGWS) which is sponsored by DARPA, DNA, and the U.S. Army. The 90 mm D1 Type II 'workhorse' Projectile is used to prove out material strength, fabrication techniques, and projectile structural integrity. The type II flight projectile is designed to allow maximum stress levels of 100-ksi when launched at 100-kilogees peak acceleration. The total weight of the projectile is 2.0 kg to attain a muzzle velocity of 3.0 km/s from a 9-Megajoule EM Gun. The Type II projectile configuration employs a tungsten nosetip plus 12 segmented tungsten penetrators, a two-piece aluminum discarding sabot, an aluminum pusher plate, and a nylon obturator. The pusher plate can incorporate either a solid or plasma armature
Valley-symmetric quasi-1D transport in ballistic graphene
Lee, Hu-Jong
We present our recent studies on gate-defined valley-symmetric one-dimensional (1D) carrier guiding in ballistic monolayer graphene and valley-symmetry-protected topological 1D transport in ballistic bilayer graphene. Successful carrier guiding was realized in ballistic monolayer graphene even in the absence of a band gap by inducing a high distinction ( more than two orders of magnitude) in the carrier density between the region of a quasi-1D channel and the rest of the top-gated regions. Conductance of a channel shows quantized values in units of 4e2/ h, suggesting that the valley symmetry is preserved. For the latter, the topological 1D conduction was realized between two closely arranged insulating regions with inverted band gaps, induced under a pair of split dual gating with polarities opposite to each other. The maximum conductance along the boundary channel showed 4e2/ h, again with the preserved valley symmetry. The 1D topological carrier guiding demonstrated in this study affords a promising route to robust valleytronic applications and sophisticated valley-associated functionalities based on 2D materials. This work was funded by the National Research Foundation of Korea.
Comparison of 1D and 2D CSR Models with Application to the FERMI(at)ELETTRA Bunch Compressors
International Nuclear Information System (INIS)
Bassi, G.; Ellison, J.A.; Heinemann, K.
2011-01-01
We compare our 2D mean field (Vlasov-Maxwell) treatment of coherent synchrotron radiation (CSR) effects with 1D approximations of the CSR force which are commonly implemented in CSR codes. In our model we track particles in 4D phase space and calculate 2D forces (1). The major cost in our calculation is the computation of the 2D force. To speed up the computation and improve 1D models we also investigate approximations to our exact 2D force. As an application, we present numerical results for the Fermi(at)Elettra first bunch compressor with the configuration described in (1).
International Nuclear Information System (INIS)
Abachi, S.
1995-07-01
Measurement of the inclusive triple differential dijet cross section, d 3 σ/dE T d η1 d η2 , at a center of mass energy √s = 1.8 TeV with the D0 detector during the 1992--1993 run. The sensitivity of this measurement to different parton distribution functions is explored. A comparison of the data to NLO theory using different parton distributions functions indicates the need for a smaller gluon content in the x range accessible at the Tevatron than is predicted by current parton distribution sets
Robertson, Chelsea L; Ishibashi, Kenji; Mandelkern, Mark A; Brown, Amira K; Ghahremani, Dara G; Sabb, Fred; Bilder, Robert; Cannon, Tyrone; Borg, Jacqueline; London, Edythe D
2015-04-15
Motor response inhibition is mediated by neural circuits involving dopaminergic transmission; however, the relative contributions of dopaminergic signaling via D1- and D2-type receptors are unclear. Although evidence supports dissociable contributions of D1- and D2-type receptors to response inhibition in rats and associations of D2-type receptors to response inhibition in humans, the relationship between D1-type receptors and response inhibition has not been evaluated in humans. Here, we tested whether individual differences in striatal D1- and D2-type receptors are related to response inhibition in human subjects, possibly in opposing ways. Thirty-one volunteers participated. Response inhibition was indexed by stop-signal reaction time on the stop-signal task and commission errors on the continuous performance task, and tested for association with striatal D1- and D2-type receptor availability [binding potential referred to nondisplaceable uptake (BPND)], measured using positron emission tomography with [(11)C]NNC-112 and [(18)F]fallypride, respectively. Stop-signal reaction time was negatively correlated with D1- and D2-type BPND in whole striatum, with significant relationships involving the dorsal striatum, but not the ventral striatum, and no significant correlations involving the continuous performance task. The results indicate that dopamine D1- and D2-type receptors are associated with response inhibition, and identify the dorsal striatum as an important locus of dopaminergic control in stopping. Moreover, the similar contribution of both receptor subtypes suggests the importance of a relative balance between phasic and tonic dopaminergic activity subserved by D1- and D2-type receptors, respectively, in support of response inhibition. The results also suggest that the stop-signal task and the continuous performance task use different neurochemical mechanisms subserving motor response inhibition. Copyright © 2015 the authors 0270-6474/15/355990-08$15.00/0.
Directory of Open Access Journals (Sweden)
Karla A. Mark
2016-10-01
Full Text Available Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, including Alzheimer’s disease, Parkinson’s disease, cognitive impairment, and cancer. In this study, we utilized Caenorhabditis elegans to examine the mechanism by which vitamin D influences aging. We found that vitamin-D3-induced lifespan extension requires the stress response pathway genes skn-1, ire-1, and xbp-1. Vitamin D3 (D3 induced expression of SKN-1 target genes but not canonical targets of XBP-1. D3 suppressed an important molecular pathology of aging, that of widespread protein insolubility, and prevented toxicity caused by human β-amyloid. Our observation that D3 improves protein homeostasis and slows aging highlights the importance of maintaining appropriate vitamin D serum levels and may explain why such a wide variety of human age-related diseases are associated with vitamin D deficiency.
Directory of Open Access Journals (Sweden)
Marion Agnes Emma Andre
2016-01-01
Full Text Available Dopamine contributes to the regulation of higher order information processing and executive control. It is important for memory consolidation processes, and for the adaptation of learned responses based on experience. In line with this, under aversive learning conditions, application of dopamine receptor antagonists prior to extinction result in enhanced memory reinstatement. Here, we investigated the contribution of the dopaminergic system to extinction and memory reinstatement (renewal of an appetitive spatial learning task in rodents. Rats were trained for 3 days in a T-maze (context ‘A’ to associate a goal arm with a food reward, despite low reward probability (acquisition phase. On day 4, extinction learning (unrewarded occurred, that was reinforced by a context change (‘B’. On day 5, re-exposure to the (unrewarded ‘A’-context took place (renewal of context ‘A’, followed by extinction of context ‘A’. In control animals, significant extinction occurred on day 4, that was followed by an initial memory reinstatement (renewal on day 5, that was, in turn, succeeded by extinction of renewal. Intracerebral treatment with a D1/D5-receptor antagonist prior to the extinction trials, elicited a potent enhancement of extinction in context ‘B’. By contrast, a D1/D5-agonist impaired renewal in context ’A’. Extinction in the ‘A’ context on day 5 was unaffected by the D1/D5-ligands. Treatment with a D2-receptor antagonist prior to extinction had no overall effect on extinction in context ‘B or renewal in context ‘A’, although extinction of the renewal effect was impaired on day 5, compared to controls.Taken together, these data suggest that dopamine acting on the D1/D5-receptor modulates both acquisition and consolidation of context-dependent extinction. By contrast, the D2-receptor may contribute to context-independent aspects of this kind of extinction learning.
Wen, Li-Li; Dang, Dong-Bin; Duan, Chun-Ying; Li, Yi-Zhi; Tian, Zheng-Fang; Meng, Qing-Jin
2005-10-03
Five novel interesting d(10) metal coordination polymers, [Zn(PDCO)(H2O)2]n (PDCO = pyridine-2,6-dicarboxylic acid N-oxide) (1), [Zn2(PDCO)2(4,4'-bpy)2(H2O)2.3H2O]n (bpy = bipyridine) (2), [Zn(PDCO)(bix)]n (bix = 1,4-bis(imidazol-1-ylmethyl)benzene) (3), [Zn(PDCO)(bbi).0.5H2O]n (bbi = 1,1'-(1,4-butanediyl)bis(imidazole)) (4), and [Cd(PDCO)(bix)(1.5).1.5H2O]n (5), have been synthesized under hydrothermal conditions and structurally characterized. Polymer 1 possesses a one-dimensional (1D) helical chainlike structure with 4(1) helices running along the c-axis with a pitch of 10.090 Angstroms. Polymer 2 has an infinite chiral two-dimensional (2D) brick-wall-like layer structure in the ac plane built from achiral components, while both 3 and 4 exhibit an infinite 2D herringbone architecture, respectively extended in the ac and ab plane. Polymer 5 features a most remarkable and unique three-dimensional (3D) porous framework with 2-fold interpenetration related by symmetry, which contains channels in the b and c directions, both distributed in a rectangular grid fashion. Compounds 1-5, with systematic variation in dimensionality from 1D to 2D to 3D, are the first examples of d(10) metal coordination polymers into which pyridinedicarboxylic acid N-oxide has been introduced. In addition, polymers 1, 4, and 5 display strong blue fluorescent emissions in the solid state. Polymer 3 exhibits a strong SHG response, estimated to be approximately 0.9 times that of urea.
International Nuclear Information System (INIS)
Rodovsky, T.J.
2006-01-01
This report presents the final hazard categorization (FHC) for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site
Energy Technology Data Exchange (ETDEWEB)
T. J. Rodovsky
2006-12-06
This report presents the final hazard categorization (FHC) for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site.
Energy Technology Data Exchange (ETDEWEB)
T. J. Rodovsky
2007-04-12
This report presents the final hazard categorization (FHC) for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site.
International Nuclear Information System (INIS)
TRodovsky, T.J.
2007-01-01
This report presents the final hazard categorization (FHC) for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site
Immune Function of Vitamin D in Type 1 Diabetes Mellitus
Directory of Open Access Journals (Sweden)
Jingbo Li
2014-06-01
Full Text Available Vitamin D is a well-known fat-soluble vitamin which is essential in the homeostasis of calcium and phosphorus. Vitamin D deficiency causes skeletal disorders, including rickets, osteomalacia, and osteoporosis. However, recent studies revealing the immunomodulatory effects of vitamin D have opened up a new understanding and possibility in this field. It has been proved that vitamin D is related to a variety of autoimmune diseases. Type 1 diabetes mellitus (T1DM, being generally accepted as autoimmune mediated, is also proposed to be associated with the vitamin D status of the human body. Here, we reviewed briefly the epidemiological correlation between the vitamin D status and prevalence of T1DM, the possible mechanisms underlying this correlation, and clinical trials focusing on the therapeutic prospects of vitamin D in the treatment of T1DM.
Directory of Open Access Journals (Sweden)
Angela Cassese
Full Text Available Over-expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (PED/PEA-15 causes insulin resistance by interacting with the D4 domain of phospholipase D1 (PLD1. Indeed, the disruption of this association restores insulin sensitivity in cultured cells over-expressing PED/PEA-15. Whether the displacement of PLD1 from PED/PEA-15 improves insulin sensitivity in vivo has not been explored yet. In this work we show that treatment with a recombinant adenoviral vector containing the human D4 cDNA (Ad-D4 restores normal glucose homeostasis in transgenic mice overexpressing PED/PEA-15 (Tg ped/pea-15 by improving both insulin sensitivity and secretion. In skeletal muscle of these mice, D4 over-expression inhibited PED/PEA-15-PLD1 interaction, decreased Protein Kinase C alpha activation and restored insulin induced Protein Kinase C zeta activation, leading to amelioration of insulin-dependent glucose uptake. Interestingly, Ad-D4 administration improved insulin sensitivity also in high-fat diet treated obese C57Bl/6 mice. We conclude that PED/PEA-15-PLD1 interaction may represent a novel target for interventions aiming at improving glucose tolerance.
Directory of Open Access Journals (Sweden)
Markus eAxer
2011-12-01
Full Text Available Functional interactions between different brain regions require connecting fiber tracts, the structural basis of the human connectome. To assemble a comprehensive structural understanding of neural network elements from the microscopic to the macroscopic dimensions, a multimodal and multiscale approach has to be envisaged. However, the integration of results from complementary neuroimaging techniques poses a particular challenge. In this paper, we describe a steadily evolving neuroimaging technique referred to as three-dimensional polarized light imaging (3D-PLI. It is based on the birefringence of the myelin sheaths surrounding axons, and enables the high-resolution analysis of myelinated axons constituting the fiber tracts. 3D-PLI provides the mapping of spatial fiber architecture in the postmortem human brain at a sub-millimeter resolution, i.e. at the mesoscale. The fundamental data structure gained by 3D-PLI is a comprehensive 3D vector field description of fibers and fiber tract orientations – the basis for subsequent tractography. To demonstrate how 3D-PLI can contribute to unravel and assemble the human connectome, a multiscale approach with the same technology was pursued. Two complementary state-of-the-art polarimeters providing different sampling grids (pixel sizes of 100 μm and 1.6 μm were used. To exemplarily highlight the potential of this approach, fiber orientation maps and 3D fiber models were reconstructed in selected regions of the brain (e.g., Corpus callosum, Internal capsule, Pons. The results demonstrate that 3D-PLI is an ideal tool to serve as an interface between the microscopic and macroscopic levels of organization of the human connectome.
Lesnikova, Yu I.; Smetannikov, O. Yu; Trufanov, A. N.; Trufanov, N. A.
2017-02-01
The impact of contact transverse forces on the birefringence of the single-mode polarization-maintaining Panda-type fiber is numerically modeled. It has been established that with a single-row power winding on a cylindrical mandrel, the fiber tension at winding is the principal factor that influences birefringence. When coiling the fiber based on the local defect microbending, the birefringence at the microbending point differs from that of the free fiber by 1.3%.
Energy Technology Data Exchange (ETDEWEB)
Seeman, P.; Niznik, H.B.; Guan, H.C.; Booth, G.; Ulpian, C. (Univ. of Toronto (Canada))
1989-12-01
Dopamine receptor types D{sub 1} and D{sub 2} can oppose enhance each other's actions for electrical, biochemical, and psychomotor effects. The authors report a D{sub 1}-D{sub 2} interaction in homogenized tissue as revealed by ligand binding. D{sub 2} agonists lowered the binding of ({sup 3}H)raclopride to D{sub 2} receptors in striatal and anterior pituitary tissues. Pretreating the tissue with the D{sub 1}-selective antagonist SCH 23390 prevented the agonist-induced decrease in ({sup 3}H)raclopride binding to D{sub 2} sites in the striatum but not in the anterior pituitary, which has no D{sub 1} receptors. Conversely, a dopamine-induced reduction in the binding of ({sup 3}H)SCH 23390 to D{sub 1} receptors could be prevented by the D{sub 2}-selective antagonist eticlopride. Receptor photolabeling experiments confirmed both these D{sub 1}-D{sub 2} interactions. The blocking effect by SCH 23390 was similar to that produced by a nonhydrolyzable guanine nucleotide analogue, and SCH 23390 reduced the number of agonist-labeled D{sub 2} receptors in the high-affinity state. Thus, the D{sub 1}-D{sub 2} link may be mediated by guanine nucleotide-binding protein components. The link may underlie D{sub 1}-D{sub 2} interactions influencing behavior, since the link was missing in over half the postmortem striata from patients with schizophrenia and Huntington disease (both diseases that show some hyperdopamine signs) but was present in human control, Alzheimer, and Parkinson striata.
26 CFR 1.430(d)-1 - Determination of target normal cost and funding target.
2010-04-01
... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Determination of target normal cost and funding target. 1.430(d)-1 Section 1.430(d)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... of target normal cost and funding target. (a) In general—(1) Overview. This section sets forth rules...
Theoretical aspects of photonic band gap in 1D nano structure of LN: MgLN periodic layer
International Nuclear Information System (INIS)
Sisodia, Namita
2015-01-01
By using the transfer matrix method, we have analyzed the photonic band gap properties in a periodic layer of LN:MgLN medium. The Width of alternate layers of LN and MgLN is in the range of hundred nanometers. The birefringent and ferroelectric properties of the medium (i.e ordinary, extraordinary refractive indices and electric dipole moment) is given due considerations in the formulation of photonic band gap. Effect of electronic transition dipole moment of the medium on photonic band gap is also taken into account. We find that photonic band gap can be modified by the variation in the ratio of the width of two medium. We explain our findings by obtaining numerical values and the effect on the photonic band gap due to variation in the ratio of alternate medium is shown graphically
Feng, Zhengyu; Chandani Perera, A D L; Fukuda, Atsuo; Vij, Jagdish K; Ishikawa, Ken; Iida, Atsuo; Takanishi, Yoichi
2017-07-01
A mixture of two selenium-containing compounds, 80 wt. % AS657 and 20 wt. % AS620, are studied with two complementary methods, electric-field-induced birefringence (EFIB) and microbeam resonant x-ray scattering (μRXS). The mixture shows the typical phase sequence of Sm-C_{A}^{*}-1/3-1/2-Sm-C^{*}-Sm-C_{α}^{*}-Sm-A, where 1/3 and 1/2 are two prototypal ferrielectric and antiferroelectric subphases with three- and four-layer unit cells, respectively. Here we designate the subphase as its q_{T} number defined by the ratio of [F]/([F]+[A]), where [F] and [A] are the numbers of synclinic ferroelectric and anticlinic antiferroelectric orderings in the unit cell, respectively. The electric field vs temperature phase diagram with EFIB contours indicates the emergence of three additional subphases, an antiferroelectric one between Sm-C_{A}^{*} and 1/3 and antiferroelectric and apparently ferrielectric ones between 1/3 and 1/2. The simplest probable q_{T}'s for these additional subphases are 1/4, 2/5, and 3/7, respectively, in the order of increasing temperature. The μRXS profiles indicate that antiferroelectric 1/4 and 2/5 approximately have the eight-layer (FAAAFAAA) and ten-layer (FAFAAFAFAA) Ising unit cells, respectively. The remaining subphase may be ferrielectric 3/7 with a seven-layer unit cell, although the evidence is partial. These experimental results are compared with the phenomenological Landau model [P. V. Dolganov and E. I. Kats, Liq. Cryst. Rev. 1, 127 (2014)2168-039610.1080/21680396.2013.869667] and the quasimolecular model [A. V. Emelyanenko and M. A. Osipov, Phys. Rev. E 68, 051703 (2003)1063-651X10.1103/PhysRevE.68.051703].
Cyclin D1 and Ewing's sarcoma/PNET: A microarray analysis.
Fagone, Paolo; Nicoletti, Ferdinando; Salvatorelli, Lucia; Musumeci, Giuseppe; Magro, Gaetano
2015-10-01
Recent immunohistochemical analyses have showed that cyclin D1 is expressed in soft tissue Ewing's sarcoma/peripheral neuroectodermal tumor (PNET) of childhood and adolescents, while it is undetectable in both embryonal and alveolar rhabdomyosarcoma. In the present paper, microarray analysis provided evidence of a significant upregulation of cyclin D1 in Ewing's sarcoma as compared to normal tissues. In addition, we confirmed our previous findings of a significant over-expression of cyclin D1 in Ewing sarcoma as compared to rhabdomyosarcoma. Bioinformatic analysis also allowed to identify some other genes, strongly correlated to cyclin D1, which, although not previously studied in pediatric tumors, could represent novel markers for the diagnosis and prognosis of Ewing's sarcoma/PNET. The data herein provided support not only the use of cyclin D1 as a diagnostic marker of Ewing sarcoma/PNET but also the possibility of using drugs targeting cyclin D1 as potential therapeutic strategies. Copyright © 2015 Elsevier GmbH. All rights reserved.
Martin, Alexander T; Tan, Melissa; Nichols, Shane M; Timothy, Emily; Kahr, Bart
2018-07-01
Accurate polarimetric measurements of the optical activity of crystals along low symmetry directions are facilitated by isotropic points, frequencies where dispersion curves of eigenrays cross and the linear birefringence disappears. We report here the optical properties and structure of achiral, uniaxial (point group D 2d ) potassium trihydrogen di-(cis-4-cyclohexene-1,2-dicarboxylate) dihydrate, whose isotropic point was previously detected (S. A. Kim, C. Grieswatch, H. Küppers, Zeit. Krist. 1993; 208:219-222) and exploited for a singular measurement of optical activity normal to the optic axis. The crystal structure associated with the aforementioned study was never published. We report it here, confirming the space group assignment I 4¯c2, along with the frequency dependence of the fundamental optical properties and the constitutive tensors by fitting optical dispersion relations to measured Mueller matrix spectra. k-Space maps of circular birefringence and of the Mueller matrix near the isotropic wavelength are measured and simulated. The signs of optical rotation are correlated with the absolute crystallographic directions. © 2018 Wiley Periodicals, Inc.
Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression.
Directory of Open Access Journals (Sweden)
Zhaoming Li
Full Text Available Six1 is one of the transcription factors that act as master regulators of development and are frequently dysregulated in cancers. However, the role of Six1 in pancreatic cancer is not clear. Here we show that the relative expression of Six1 mRNA is increased in pancreatic cancer and correlated with advanced tumor stage. In vitro functional assays demonstrate that forced overexpression of Six1 significantly enhances the growth rate and proliferation ability of pancreatic cancer cells. Knockdown of endogenous Six1 decreases the proliferation of these cells dramatically. Furthermore, Six1 promotes the growth of pancreatic cancer cells in a xenograft assay. We also show that the gene encoding cyclin D1 is a direct transcriptional target of Six1 in pancreatic cancer cells. Overexpression of Six1 upregulates cyclin D1 mRNA and protein, and significantly enhances the activity of the cyclin D1 promoter in PANC-1 cells. We demonstrate that Six1 promotes cell cycle progression and proliferation by upregulation of cyclin D1. These data suggest that Six1 is overexpressed in pancreatic cancer and may contribute to the increased cell proliferation through upregulation of cyclin D1.
Coupled 1D-2D hydrodynamic inundation model for sewer overflow: Influence of modeling parameters
Directory of Open Access Journals (Sweden)
Adeniyi Ganiyu Adeogun
2015-10-01
Full Text Available This paper presents outcome of our investigation on the influence of modeling parameters on 1D-2D hydrodynamic inundation model for sewer overflow, developed through coupling of an existing 1D sewer network model (SWMM and 2D inundation model (BREZO. The 1D-2D hydrodynamic model was developed for the purpose of examining flood incidence due to surcharged water on overland surface. The investigation was carried out by performing sensitivity analysis on the developed model. For the sensitivity analysis, modeling parameters, such as mesh resolution Digital Elevation Model (DEM resolution and roughness were considered. The outcome of the study shows the model is sensitive to changes in these parameters. The performance of the model is significantly influenced, by the Manning's friction value, the DEM resolution and the area of the triangular mesh. Also, changes in the aforementioned modeling parameters influence the Flood characteristics, such as the inundation extent, the flow depth and the velocity across the model domain. Keywords: Inundation, DEM, Sensitivity analysis, Model coupling, Flooding
International Nuclear Information System (INIS)
Monsma, F.J. Jr.; Sibley, D.R.
1989-01-01
The presence of D1 dopamine receptors in the parathyroid gland has been proposed based on the demonstration of dopaminergic regulation of adenylate cyclase activity and parathyroid hormone release in dispersed bovine parathyroid cells. Using a radioiodinated D1 selective antagonist [125I]-SCH 23982, we have now directly labeled and characterized the D1 dopamine receptors in bovine parathyroid gland membranes. [125I]-SCH 23982 binds in a saturable manner with high affinity and low nonspecific binding to membranes prepared from bovine parathyroid glands. D1 dopamine receptors are present in this preparation at a concentration of approximately 130 fMoles/mg protein and [125I]-SCH 23982 binding increases with increasing protein concentration in a linear fashion. Determination of the Kd using the association (k1) and dissociation (k-1) rate constants revealed good agreement with the Kd determined by saturation analysis (390 pM vs. 682 pM, respectively). Inhibition of 0.3 nM [125I]-SCH 23982 binding by a series of dopaminergic antagonists verified the D1 nature of this binding site, exhibiting appropriate affinities and rank order of potency. The competition curves of all antagonists exhibited Hill coefficients that were not significantly different from 1. Inhibition of [125I]-SCH 23982 binding by dopamine and other dopaminergic agonists revealed the presence of high and low affinity agonist binding sites. Addition of 200 microM GppNHp effected a complete conversion of high affinity dopamine binding sites to a homogeneous population of low affinity dopamine sites. The D1 receptors identified in the parathyroid gland with [125I]-SCH 23982 appear to be pharmacologically identical with those previously characterized in the central nervous system
DEFF Research Database (Denmark)
Davidsen, Steffen; Löwe, Roland; Thrysøe, Cecilie
2017-01-01
Evaluation of pluvial flood risk is often based on computations using 1D/2D urban flood models. However, guidelines on choice of model complexity are missing, especially for one-dimensional (1D) network models. This study presents a new automatic approach for simplification of 1D hydraulic networ...
Comparing 1.5D ONETWO and 2D SOLPS analyses of inter-ELM H-mode plasma in DIII-D
International Nuclear Information System (INIS)
Owen, Larry W.; Canik, John; Groebner, R.; Callen, J.D.; Bonnin, X.; Osborne, T.H.
2010-01-01
A DIII-D inter-ELM H-mode plasma that is in approximate transport equilibrium is analysed with the 1.5D ONETWO core code and the 2D SOLPS code. In order to investigate the importance of core-edge coupling and 2D effects, including divertor fuelling across the X-point and poloidal asymmetries that are not explicitly included in ONETWO, the domain of SOLPS is extended to very near the magnetic axis. Two principal objectives are (1) to determine whether poloidal asymmetries in the plasma distributions are large enough to vitiate a core-type interpretive plasma transport analysis and (2) to determine whether the interpretive transport coefficients and neutral beam power and particle sources from ONETWO, when used in 2D SOLPS full plasma simulations, yield the same quality fits to the measured upstream density and temperature profiles as obtained with ONETWO. Results show that only a small increase in the separatrix value of the particle diffusion coefficient, and no change in the thermal diffusivities from ONETWO was needed to get excellent agreement of the upstream SOLPS density and temperature profiles and the Thomson scattering and CER data. Good agreement of the ONETWO and SOLPS flux surface averaged distributions of the core electron and D+ densities and temperatures are also obtained. Likewise the C6+ density, with a simple chemical sputtering model based on a constant fraction of the divertor D+ flux, the core heat and particle fluxes and the neutral density reveal no 2D effects in the core/pedestal region that would vitiate a 1.5D treatment of the inter-ELM H-mode plasma.
100-D Ponds closure plan. Revision 1
International Nuclear Information System (INIS)
Petersen, S.W.
1997-09-01
The 100-D Ponds is a Treatment, Storage, and Disposal (TSD) unit on the Hanford Facility that received both dangerous and nonregulated waste. This Closure Plan (Rev. 1) for the 100-D Ponds TSD unit consists of a RCRA Part A Dangerous Waste Permit Application (Rev. 3), a RCRA Closure Plan, and supporting information contained in the appendices to the plan. The closure plan consists of eight chapters containing facility description, process information, waste characteristics, and groundwater monitoring data. There are also chapters containing the closure strategy and performance standards. The strategy for the closure of the 100-D Ponds TSD unit is clean closure. Appendices A and B of the closure plan demonstrate that soil and groundwater beneath 100-D Ponds are below cleanup limits. All dangerous wastes or dangerous waste constituents or residues associated with the operation of the ponds have been removed, therefore, human health and the environment are protected. Discharges to the 100-D Ponds, which are located in the 100-DR-1 operable unit, were discontinued in June 1994. Contaminated sediment was removed from the ponds in August 1996. Subsequent sampling and analysis demonstrated that there is no contamination remaining in the ponds, therefore, this closure plan is a demonstration of clean closure
Sáinz, Neira; Rodríguez, Amaia; Catalán, Victoria; Becerril, Sara; Ramírez, Beatriz; Lancha, Andoni; Burgos-Ramos, Emma; Gómez-Ambrosi, Javier; Frühbeck, Gema
2012-01-01
Leptin improves insulin sensitivity in skeletal muscle. Our goal was to determine whether proteins controlling GLUT4 traffic are altered by leptin deficiency and in vivo leptin administration in skeletal muscle of wild type and ob/ob mice. Leptin-deficient ob/ob mice were divided in three groups: control, leptin-treated (1 mg/kg/d) and leptin pair-fed ob/ob mice. Microarray analysis revealed that 1,546 and 1,127 genes were regulated by leptin deficiency and leptin treatment, respectively. Among these, we identified 24 genes involved in intracellular vesicle-mediated transport in ob/ob mice. TBC1 domain family, member 1 (Tbc1d1), a negative regulator of GLUT4 translocation, was up-regulated (P = 0.001) in ob/ob mice as compared to wild types. Importantly, leptin treatment reduced the transcript levels of Tbc1d1 (P<0.001) and Tbc1d4 (P = 0.004) in the leptin-treated ob/ob as compared to pair-fed ob/ob animals. In addition, phosphorylation levels of TBC1D1 and TBC1D4 were enhanced in leptin-treated ob/ob as compared to control ob/ob (P = 0.015 and P = 0.023, respectively) and pair-fed ob/ob (P = 0.036 and P = 0.034, respectively) mice. Despite similar GLUT4 protein expression in wild type and ob/ob groups a different immunolocalization of this protein was evidenced in muscle sections. Leptin treatment increased GLUT4 immunoreactivity in gastrocnemius and extensor digitorum longus sections of leptin-treated ob/ob mice. Moreover, GLUT4 protein detected in immunoprecipitates from TBC1D4 was reduced by leptin replacement compared to control ob/ob (P = 0.013) and pair-fed ob/ob (P = 0.037) mice. Our findings suggest that leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4. PMID:22253718
Czech Academy of Sciences Publication Activity Database
Attolino, E.; Bonaccorsi, F.; Catelani, G.; D'Andrea, F.; Křenek, Karel; Bezouška, Karel; Křen, Vladimír
2008-01-01
Roč. 27, č. 3 (2008), s. 156-171 ISSN 0732-8303 R&D Projects: GA AV ČR IAA400200503; GA MŠk(CZ) LC06010; GA MŠk OC 136 Grant - others:GA MŠk(CZ) COST D34 Institutional research plan: CEZ:AV0Z50200510 Keywords : reductions * nkr-p1 receptor * nk cells Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.114, year: 2008
Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine.
Ares-Santos, S; Granado, N; Oliva, I; O'Shea, E; Martin, E D; Colado, M I; Moratalla, R
2012-02-01
Methamphetamine (METH) is a potent, highly addictive psychostimulant consumed worldwide. In humans and experimental animals, repeated exposure to this drug induces persistent neurodegenerative changes. Damage occurs primarily to dopaminergic neurons, accompanied by gliosis. The toxic effects of METH involve excessive dopamine (DA) release, thus DA receptors are highly likely to play a role in this process. To define the role of D(1) receptors in the neurotoxic effects of METH we used D(1) receptor knock-out mice (D(1)R(-/-)) and their WT littermates. Inactivation of D(1)R prevented METH-induced dopamine fibre loss and hyperthermia, and increases in gliosis and pro-inflammatory molecules such as iNOS in the striatum. In addition, D(1)R inactivation prevented METH-induced loss of dopaminergic neurons in the substantia nigra. To explore the relationship between hyperthermia and neurotoxicity, METH was given at high ambient temperature (29 °C). In this condition, D(1)R(-/-) mice developed hyperthermia following drug delivery and the neuroprotection provided by D(1)R inactivation at 23 °C was no longer observed. However, reserpine, which empties vesicular dopamine stores, blocked hyperthermia and strongly potentiated dopamine toxicity in D(1)R(-/-) mice, suggesting that the protection afforded by D(1)R inactivation is due to both hypothermia and higher stored vesicular dopamine. Moreover, electrical stimulation evoked higher DA overflow in D(1)R(-/-) mice as demonstrated by fast scan cyclic voltammetry despite their lower basal DA content, suggesting higher vesicular DA content in D(1)R(-/-) than in WT mice. Altogether, these results indicate that the D(1)R plays a significant role in METH-induced neurotoxicity by mediating drug-induced hyperthermia and increasing the releasable cytosolic DA pool. Copyright © 2011. Published by Elsevier Inc.
Koszewski, Nicholas J; Horst, Ronald L; Goff, Jesse P
2012-10-01
Synthetic conjugation of a glucuronide to 1,25-dihydroxyvitamin D3 (1,25D3) to produce β-25-monoglucuronide-1,25D3 (βGluc-1,25D3) renders the hormone biologically inactive and resistant to mammalian digestive enzymes. However, β-glucuronidase produced by bacteria in the lower intestinal tract can cleave off the glucuronide, releasing the active hormone. In mice given a single oral dose of 1,25D3, 24-hydroxylase (Cyp24a1) gene expression was strongly enhanced in the duodenum, but not in the colon, despite circulating concentrations of 1,25D3 that peaked at ∼3.0 nmol/l. In contrast, in mice treated with an equimolar dose of βGluc-1,25D3, Cyp24a1 gene expression increased 700-fold in the colon but was significantly weaker in the duodenum compared with mice treated with 1,25D3. Similar results were observed with another vitamin D-dependent gene. When administered subcutaneously, 1,25D3 weakly stimulated colon Cyp24a1 gene expression while βGluc-1,25D3 again resulted in strong enhancement. Surgical ligation to block passage of ingesta beyond the upper intestinal tract abolished upregulation of colon Cyp24a1 gene expression by orally and subcutaneously administered βGluc-1,25D3. Feeding βGluc-1,25D3 for 5 days revealed a linear, dose-dependent increase in colon Cyp24a1 gene expression but did not significantly increase plasma 1,25D3 or calcium concentrations. This study indicates that the colon is relatively insensitive to circulating concentrations of 1,25D3 and that the strongest gene enhancement occurs when the hormone reaches the colon via the lumen of the intestinal tract. These findings have broad implications for the use of vitamin D compounds in colon disorders and set the stage for future therapeutic studies utilizing βGluc-1,25D3 in their treatment.
Directory of Open Access Journals (Sweden)
Todd C. Pataky
2016-11-01
Full Text Available One-dimensional (1D kinematic, force, and EMG trajectories are often analyzed using zero-dimensional (0D metrics like local extrema. Recently whole-trajectory 1D methods have emerged in the literature as alternatives. Since 0D and 1D methods can yield qualitatively different results, the two approaches may appear to be theoretically distinct. The purposes of this paper were (a to clarify that 0D and 1D approaches are actually just special cases of a more general region-of-interest (ROI analysis framework, and (b to demonstrate how ROIs can augment statistical power. We first simulated millions of smooth, random 1D datasets to validate theoretical predictions of the 0D, 1D and ROI approaches and to emphasize how ROIs provide a continuous bridge between 0D and 1D results. We then analyzed a variety of public datasets to demonstrate potential effects of ROIs on biomechanical conclusions. Results showed, first, that a priori ROI particulars can qualitatively affect the biomechanical conclusions that emerge from analyses and, second, that ROIs derived from exploratory/pilot analyses can detect smaller biomechanical effects than are detectable using full 1D methods. We recommend regarding ROIs, like data filtering particulars and Type I error rate, as parameters which can affect hypothesis testing results, and thus as sensitivity analysis tools to ensure arbitrary decisions do not influence scientific interpretations. Last, we describe open-source Python and MATLAB implementations of 1D ROI analysis for arbitrary experimental designs ranging from one-sample t tests to MANOVA.
Ageev, E.S.; Alexandrov, Yu.; Alexeev, G.D.; Amoroso, A.; Badelek, B.; Balestra, F.; Ball, J.; Baum, G.; Bedfer, Y.; Berglund, P.; Bernet, C.; Bertini, R.; Birsa, R.; Bisplinghoff, J.; Bordalo, P.; Bradamante, F.; Bravar, A.; Bressan, A.; Burtin, E.; Bussa, M.P.; Bytchkov, V.N.; Cerini, L.; Chapiro, A.; Cicuttin, A.; Colantoni, M.; Colavita, A.A.; Costa, S.; Crespo, M.L.; d'Hose, N.; Dalla Torre, S.; Dasgupta, S.S.; De Masi, R.; Dedek, N.; Denisov, O.Yu.; Dhara, L.; Diaz Kavka, V.; Dinkelbach, A.M.; Dolgopolov, A.V.; Donskov, S.V.; Dorofeev, V.A.; Doshita, N.; Duic, V.; Dunnweber, W.; Ehlers, J.; Eversheim, P.D.; Eyrich, W.; Fabro, M.; Faessler, M.; Falaleev, V.; Fauland, P.; Ferrero, A.; Ferrero, L.; Finger, M.; Finger, M., Jr.; Fischer, H.; Franz, J.; Friedrich, J.M.; Frolov, V.; Fuchs, U.; Garfagnini, R.; Gautheron, F.; Gavrichtchouk, O.P.; Gerassimov, S.; Geyer, R.; Giorgi, M.; Gobbo, B.; Goertz, S.; Gorin, A.M.; Grajek, O.A.; Grasso, A.; Grube, B.; Grunemaier, A.; Hannappel, J.; von Harrach, D.; Hasegawa, T.; Hedicke, S.; Heinsius, F.H.; Hermann, R.; He, C.; Hinterberger, F.; von Hodenberg, M.; Horikawa, N.; Horikawa, S.; Ijaduola, R.B.; Ilgner, C.; Ioukaev, A.I.; Ishimoto, S.; Ivanov, O.; Iwata, T.; Jahn, R.; Janata, A.; Joosten, R.; Jouravlev, N.I.; Kabuss, E.; Kalinnikov, V.; Kang, D.; Karstens, F.; Kastaun, W.; Ketzer, B.; Khaustov, G.V.; Khokhlov, Yu.A.; Khomutov, N.V.; Kisselev, Yu.; Klein, F.; Koblitz, S.; Koivuniemi, J.H.; Kolosov, V.N.; Komissarov, E.V.; Kondo, K.; Konigsmann, Kay; Konoplyannikov, A.K.; Konorov, I.; Konstantinov, V.F.; Korentchenko, A.S.; Korzenev, A.; Kotzinian, A.M.; Koutchinski, N.A.; Kowalik, K.; Kravchuk, N.P.; Krivokhizhin, G.V.; Kroumchtein, Z.V.; Kuhn, R.; Kunne, F.; Kurek, K.; Ladygin, M.E.; Lamanna, M.; Le Goff, J.M.; Leberig, M.; Lichtenstadt, J.; Liska, T.; Ludwig, I.; Maggiora, A.; Maggiora, M.; Magnon, A.; Mallot, G.K.; Manuilov, I.V.; Marchand, C.; Marroncle, J.; Martin, A.; Marzec, J.; Matsuda, T.; Maximov, A.N.; Medved, K.S.; Meyer, W.; Mielech, A.; Mikhailov, Yu.V.; Moinester, M.A.; Nahle, O.; Nassalski, J.; Neliba, S.; Neyret, D.P.; Nikolaenko, V.I.; Nozdrin, A.A.; Obraztsov, V.F.; Olshevsky, A.G.; Ostrick, M.; Padee, A.; Pagano, P.; Panebianco, S.; Panzieri, D.; Paul, S.; Pereira, H.D.; Peshekhonov, D.V.; Peshekhonov, V.D.; Piragino, G.; Platchkov, S.; Platzer, K.; Pochodzalla, J.; Polyakov, V.A.; Popov, A.A.; Pretz, J.; Quintans, C.; Ramos, S.; Rebourgeard, P.C.; Reicherz, G.; Reymann, J.; Rith, K.; Rozhdestvensky, A.M.; Rondio, E.; Sadovski, A.B.; Saller, E.; Samoylenko, V.D.; Sandacz, A.; Sans, M.; Sapozhnikov, M.G.; Savin, Igor A.; Schiavon, P.; Schill, C.; Schmidt, T.; Schmitt, H.; Schmitt, L.; Shevchenko, O.Yu.; Shishkin, A.A.; Siebert, H.-W.; Sinha, L.; Sissakian, A.N.; Skachkova, A.; Slunecka, M.; Smirnov, G.I.; Sozzi, F.; Sugonyaev, V.P.; Srnka, A.; Stinzing, F.; Stolarski, M.; Sulc, M.; Sulej, R.; Takabayashi, N.; Tchalishev, V.V.; Tessarotto, F.; Teufel, A.; Thers, D.; Tkatchev, L.G.; Toeda, T.; Tretyak, V.I.; Trusov, Sergey V.; Varanda, M.; Virius, M.; Vlassov, N.V.; Wagner, M.; Webb, R.; Weise, E.; Weitzel, Q.; Wiedner, U.; Wiesmann, M.; Windmolders, R.; Wirth, S.; Wislicki, W.; Zanetti, A.M.; Zaremba, K.; Zhao, J.; Ziegler, R.; Zvyagin, A.
2007-01-01
We present a precise measurement of the deuteron longitudinal spin asymmetry $A_1^d$ and of the deuteron spin-dependent structure function $g_1^d$ at $Q^2 < $ 1~(GeV/$c$)$^2$ and $4\\cdot$10$^{-5} < x < $~2.5$\\cdot$10$^{-2}$ based on the data collected by the COMPASS experiment at CERN during the years 2002 and 2003. The statistical precision is tenfold better than that of the previous measurement in this region. The measured $A_1^d$ and $g_1^d$ are found to be consistent with zero in the whole range of $x$.
International Nuclear Information System (INIS)
Kim, Mi-Sun; Shin, Dong Hae
2010-01-01
In this study, d,d-heptose-1,7-bisphosphate phosphatase has been cloned, expressed, purified and crystallized. d,d-Heptose-1,7-bisphosphate phosphatase (GmhB), which is involved in the third step of the NDP-heptose biosynthesis pathway, converts d,d-heptose-1,7-bisphosphate to d,d-heptose-1-phosphate. This biosynthesis pathway is a target for new antibiotics or antibiotic adjuvants for Gram-negative pathogens. Burkholderia thailandensis is a useful surrogate organism for studying the pathogenicity of melioidosis owing to its extensive genomic similarity to B. pseudomallei. Melioidosis caused by B. pseudomallei is a serious invasive disease of animals and humans in tropical and subtropical areas. In this study, GmhB has been cloned, expressed, purified and crystallized. X-ray data have also been collected to 2.50 Å resolution using synchrotron radiation. The crystal belonged to space group P6, with unit-cell parameters a = 243.2, b = 243.2, c = 41.1 Å
Ghostine, Rabih
2014-12-01
In open channel networks, flow is usually approximated by the one-dimensional (1D) Saint-Venant equations coupled with an empirical junction model. In this work, a comparison in terms of accuracy and computational cost between a coupled 1D-2D shallow water model and a fully two-dimensional (2D) model is presented. The paper explores the ability of a coupled model to simulate the flow processes during supercritical flows in crossroads. This combination leads to a significant reduction in the computational time, as a 1D approach is used in branches and a 2D approach is employed in selected areas only where detailed flow information is essential. Overall, the numerical results suggest that the coupled model is able to accurately simulate the main flow processes. In particular, hydraulic jumps, recirculation zones, and discharge distribution are reasonably well reproduced and clearly identified. Overall, the proposed model leads to a 30% reduction in run times. © 2014 International Association for Hydro-Environment Engineering and Research.
Radiosynthesis, rodent biodistribution, and metabolism of 1-deoxy-1-[18F]fluoro-d-fructose
International Nuclear Information System (INIS)
Haradahira, Terushi; Tanaka, Akihiro; Maeda, Minoru; Kanazawa, Yoko; Ichiya, Yu-Ichi; Masuda, Kouji
1995-01-01
Fluorine-18 labeled analog of d-fructose, 1-deoxy-1-[ 18 F]fluoro-d-fructose (1-[ 18 F]FDFrc), was synthesized by nucleophilic substitution of [ 18 F]fluoride ion and the effect of the fluorine substitution on its in vivo metabolism was investigated. The tissue distributions of 1-[ 18 F]FDFrc in rats and tumor bearing mice showed initial high uptake and subsequent rapid washout of the radioactivity in the principal sites of d-fructose metabolism (kidneys, liver and small intestine). The uptakes in the brain and tumor (fibrosarcoma) were the lowest and moderate, respectively, but tended to increase with time. The in vivo metabolic studies of 1-[ 18 F]FDFrc and nonradiactive 1-FDFrc in mouse brain and tumor showed that the fluorinated analog remained unmetabolized in these tissues, indicating that the substitution of fluorine at the C-1 position produces a nonmetabolizable analog of d-fructose. Thus, 1-[ 18 F]FDFrc had no features of a metabolic trapping tracer without showing any appreciable organ or tumor specific localization
An interesting charmonium state formation and decay: p p-bar → 1 D2 → 1 P1γ
International Nuclear Information System (INIS)
Anselmino, M.; Caruso, F.; Universidade do Estado, Rio de Janeiro, RJ; Murgia, F.; Negrao, M.R.
1994-01-01
Massless perturbative QCD forbids, at leading order, the exclusive annihilation of proton-antiproton into some charmonium states, which however, have been observed in the pp channel, indicating the significance of higher order and non perturbative effects in the few GeV energy region. The most well known cases are those of the 1 S 0 (η c ) and the 1 P 1 . The case of the 1 D 2 is considered here and a way of detecting such a state through its typical angular distribution in the radiative decay 1 D 2 -> 1 D 2 -> 1 P 1 γ is suggested. Estimates of the branching ratio BR( 1 D 2 ->pp), as given by a quark-diquark model of the nucleon, mass corrections and an instanton induced process are presented. (author). 15 refs
Herpes simplex virus glycoprotein D relocates nectin-1 from intercellular contacts.
Bhargava, Arjun K; Rothlauf, Paul W; Krummenacher, Claude
2016-12-01
Herpes simplex virus (HSV) uses the cell adhesion molecule nectin-1 as a receptor to enter neurons and epithelial cells. The viral glycoprotein D (gD) is used as a non-canonical ligand for nectin-1. The gD binding site on nectin-1 overlaps with a functional adhesive site involved in nectin-nectin homophilic trans-interaction. Consequently, when nectin-1 is engaged with a cellular ligand at cell junctions, the gD binding site is occupied. Here we report that HSV gD is able to disrupt intercellular homophilic trans-interaction of nectin-1 and induce a rapid redistribution of nectin-1 from cell junctions. This movement does not require the receptor's interaction with the actin-binding adaptor afadin. Interaction of nectin-1 with afadin is also dispensable for virion surfing along nectin-1-rich filopodia. Cells seeded on gD-coated surfaces also fail to accumulate nectin-1 at cell contact. These data indicate that HSV gD affects nectin-1 locally through direct interaction and more globally through signaling. Copyright © 2016 Elsevier Inc. All rights reserved.
Proton density modulation of D atoms in PdD/sub 1-x/
International Nuclear Information System (INIS)
Mueller, M.H.; Brun, T.O.; Hitterman, R.L.; Knott, H.W.; Satterthwaite, C.B.; Ellis, T.E.
1979-01-01
Recent resistivity and neutron diffraction measurements have provided evidence for ordering of D(H) atoms on the octahedral interstitial sites of PdD/sub 1-x/. This order--disorder transition is responsible for the 50 K anomaly which has been reported in many of the physical properties. Neutron diffraction measurements on a PdD 0 76 single crystal revealed satellite reflection at (4/5,2/5,0) and equivalent positions. These satellites can be accounted for by a multi-domained tetragonal unit cell with a/sub t/ = a/sub c/ root 5/2 and c/sub t/ = c/sub a/. This ordered state can be described as a deuteron density wave along a cubic direction. This density is modulated such that four fully occupied planes (Pd and D) are followed by a vacant plane
Thermoelectric Power Factor Limit of a 1D Nanowire
Chen, I.-Ju; Burke, Adam; Svilans, Artis; Linke, Heiner; Thelander, Claes
2018-04-01
In the past decade, there has been significant interest in the potentially advantageous thermoelectric properties of one-dimensional (1D) nanowires, but it has been challenging to find high thermoelectric power factors based on 1D effects in practice. Here we point out that there is an upper limit to the thermoelectric power factor of nonballistic 1D nanowires, as a consequence of the recently established quantum bound of thermoelectric power output. We experimentally test this limit in quasiballistic InAs nanowires by extracting the maximum power factor of the first 1D subband through I -V characterization, finding that the measured maximum power factors conform to the theoretical limit. The established limit allows the prediction of the achievable power factor of a specific nanowire material system with 1D electronic transport based on the nanowire dimension and mean free path. The power factor of state-of-the-art semiconductor nanowires with small cross section and high crystal quality can be expected to be highly competitive (on the order of mW /m K2 ) at low temperatures. However, they have no clear advantage over bulk materials at, or above, room temperature.
Two-phase 1D+1D model of a DMFC: development and validation on extensive operating conditions range
Energy Technology Data Exchange (ETDEWEB)
Casalegno, A.; Marchesi, R.; Parenti, D. [Dipartimento di Energetica, Politecnico di Milano (Italy)
2008-02-15
A two-phase 1D+1D model of a direct methanol fuel cell (DMFC) is developed, considering overall mass balance, methanol transport in gas phase through anode diffusion layer, methanol and water crossover. The model is quantitatively validated on an extensive range of operating conditions, 24 polarisation curves. The model accurately reproduces DMFC performance in the validation range and, outside this, it is able to predict values under feasible operating conditions. Finally, the estimations of methanol crossover flux are qualitatively and quantitatively similar to experimental measures and the main local quantities' trends are coherent with results obtained with more complex models. (Abstract Copyright [2008], Wiley Periodicals, Inc.)
Kiss, Tibor; Balla, Krisztina; Veisz, Ottó; Láng, László; Bedő, Zoltán; Griffiths, Simon; Isaac, Peter; Karsai, Ildikó
2014-01-01
Heading of cereals is determined by complex genetic and environmental factors in which genes responsible for vernalization and photoperiod sensitivity play a decisive role. Our aim was to use diagnostic molecular markers to determine the main allele types in VRN - A1 , VRN - B1 , VRN - D1 , PPD - B1 and PPD - D1 in a worldwide wheat collection of 683 genotypes and to investigate the effect of these alleles on heading in the field. The dominant VRN - A1 , VRN - B1 and VRN - D1 alleles were present at a low frequency. The PPD - D1a photoperiod-insensitive allele was carried by 57 % of the cultivars and was most frequent in Asian and European cultivars. The PPD - B1 photoperiod-insensitive allele was carried by 22 % of the genotypes from Asia, America and Europe. Nine versions of the PPD - B1 -insensitive allele were identified based on gene copy number and intercopy structure. The allele compositions in PPD - D1 , PPD - B1 and VRN - D1 significantly influenced heading and together explained 37.5 % of the phenotypic variance. The role of gene model increased to 39.1 % when PPD - B1 intercopy structure was taken into account instead of overall PPD - B1 type (sensitive vs. insensitive). As a single component, PPD - D1 had the most important role (28.0 % of the phenotypic variance), followed by PPD - B1 (12.3 % for PPD - B1 _overall, and 15.1 % for PPD - B1 _intercopy) and VRN - D1 (2.2 %). Significant gene interactions were identified between the marker alleles within PPD - B1 and between VRN - D1 and the two PPD1 genes. The earliest heading genotypes were those with the photoperiod-insensitive allele in PPD - D1 and PPD - B1 , and with the spring allele for VRN - D1 and the winter alleles for VRN - A1 and VRN - B1 . This combination could only be detected in genotypes from Southern Europe and Asia. Late-heading genotypes had the sensitivity alleles for both PPD1 genes, regardless of the allelic composition of the VRN1 genes. There was a 10-day difference in
Comparison between 3D and 1D simulations of a regenerative blower for fuel cell applications
International Nuclear Information System (INIS)
Badami, M.; Mura, M.
2012-01-01
Highlights: ► A hydrogen recirculation blower for automotive fuel cells applications is studied. ► A 3D CFD analysis has been carried out to better understand the internal flows of the machine. ► The CFD results are compared to a 1D model set up by the authors in previous works. ► The main hypotheses put forward for the theoretical 1D model are compatible with the 3D analysis. - Abstract: A 3D Computational Fluid Dynamics (CFD) analysis has been carried out to better understand the internal fluid dynamics of a regenerative blower used for hydrogen recirculation in a Proton Exchange Membrane (PEM), Fuel Cell (FC) utilized for automotive applications. The obtained results are used to highlight the motion of the fluid in the vanes and in the side channel of the machine and to verify the main hypotheses put forward concerning the theoretical 1D model set up by the authors in previous works on the basis of the momentum exchange theory. Finally, the CFD analysis has been used to point out the effect of the slope of the vanes on the performance of the regenerative blower, and the results have been compared with those obtained using of the 1D model.
Energy Technology Data Exchange (ETDEWEB)
J.D. Ludowise
2009-06-17
This report presents the final hazard categorization for the remediation of the 118-D-1, 118-D-2, 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site. A material at risk calculation was performed that determined the radiological inventory for each burial ground to be Hazard Category 3.
Energy Technology Data Exchange (ETDEWEB)
Upadhyay, Santosh Kumar; Verone, Alissa; Shoemaker, Suzanne [Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263 (United States); Qin, Maochun; Liu, Song [Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263 (United States); Campbell, Moray; Hershberger, Pamela A., E-mail: pamela.hershberger@roswellpark.org [Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263 (United States)
2013-11-08
1,25-dihydroxyvitamin D{sub 3} (1,25(OH){sub 2}D{sub 3}) exerts anti-proliferative activity by binding to the vitamin D receptor (VDR) and regulating gene expression. We previously reported that non-small cell lung cancer (NSCLC) cells which harbor epidermal growth factor receptor (EGFR) mutations display elevated VDR expression (VDR{sup high}) and are vitamin D-sensitive. Conversely, those with K-ras mutations are VDR{sup low} and vitamin D-refractory. Because EGFR mutations are found predominately in NSCLC cells with an epithelial phenotype and K-ras mutations are more common in cells with a mesenchymal phenotype, we investigated the relationship between vitamin D signaling capacity and the epithelial mesenchymal transition (EMT). Using NSCLC cell lines and publically available lung cancer cell line microarray data, we identified a relationship between VDR expression, 1,25(OH){sub 2}D{sub 3} sensitivity, and EMT phenotype. Further, we discovered that 1,25(OH){sub 2}D{sub 3} induces E-cadherin and decreases EMT-related molecules SNAIL, ZEB1, and vimentin in NSCLC cells. 1,25(OH){sub 2}D{sub 3}-mediated changes in gene expression are associated with a significant decrease in cell migration and maintenance of epithelial morphology. These data indicate that 1,25(OH){sub 2}D{sub 3} opposes EMT in NSCLC cells. Because EMT is associated with increased migration, invasion, and chemoresistance, our data imply that 1,25(OH){sub 2}D{sub 3} may prevent lung cancer progression in a molecularly defined subset of NSCLC patients.
Directory of Open Access Journals (Sweden)
Verónica González Pardo
2012-04-01
Full Text Available La forma hormonalmente activa de la vitamina D, 1α,25(OH2-vitamina D3 (1α,25(OH2D3, además de desempeñar un rol crucial en el mantenimiento de la homeostasis de calcio en el cuerpo, también regula el crecimiento y la diferenciación de diferentes tipos celulares, incluyendo células cancerosas. Actualmente hay numerosos estudios que investigan los efectos de la hormona en estas células, debido al interés en el uso terapéutico del 1α,25(OH2D3 y de análogos con menor actividad calcémica para el tratamiento o prevención del cáncer. En este trabajo de revisión se describe el sistema endocrino de la vitamina D, su mecanismo de acción, su acción antineoplásica y se provee información sobre los últimos avances en el estudio de nuevos análogos de la hormona con menos actividad calcémica para el tratamiento del cáncer.The hormonal form of vitamin D, 1α,25(OH2-vitamin D3 (1α,25(OH2D3, in addition of playing a central role in the control of calcium homeostasis in the body, regulates the growth and differentiation of different cell types, including cancer cells. At present several epidemiologic and clinical studies investigate the effect of the hormone in these cells due to the interest in the therapeutic use of 1α,25(OH2D3 and analogues with less calcemic activity for prevention or treatment of cancer. This review describes vitamin D endocrine system, its mechanism of action, its antineoplastic activity and provides information about the latest advances in the study of new hormone analogues with less calcemic activity for cancer treatment.
In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward.
Calipari, Erin S; Bagot, Rosemary C; Purushothaman, Immanuel; Davidson, Thomas J; Yorgason, Jordan T; Peña, Catherine J; Walker, Deena M; Pirpinias, Stephen T; Guise, Kevin G; Ramakrishnan, Charu; Deisseroth, Karl; Nestler, Eric J
2016-03-08
The reinforcing and rewarding properties of cocaine are attributed to its ability to increase dopaminergic transmission in nucleus accumbens (NAc). This action reinforces drug taking and seeking and leads to potent and long-lasting associations between the rewarding effects of the drug and the cues associated with its availability. The inability to extinguish these associations is a key factor contributing to relapse. Dopamine produces these effects by controlling the activity of two subpopulations of NAc medium spiny neurons (MSNs) that are defined by their predominant expression of either dopamine D1 or D2 receptors. Previous work has demonstrated that optogenetically stimulating D1 MSNs promotes reward, whereas stimulating D2 MSNs produces aversion. However, we still lack a clear understanding of how the endogenous activity of these cell types is affected by cocaine and encodes information that drives drug-associated behaviors. Using fiber photometry calcium imaging we define D1 MSNs as the specific population of cells in NAc that encodes information about drug associations and elucidate the temporal profile with which D1 activity is increased to drive drug seeking in response to contextual cues. Chronic cocaine exposure dysregulates these D1 signals to both prevent extinction and facilitate reinstatement of drug seeking to drive relapse. Directly manipulating these D1 signals using designer receptors exclusively activated by designer drugs prevents contextual associations. Together, these data elucidate the responses of D1- and D2-type MSNs in NAc to acute cocaine and during the formation of context-reward associations and define how prior cocaine exposure selectively dysregulates D1 signaling to drive relapse.
Chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing.
Vasconcelos, Daniela P; Costa, Madalena; Neves, Nuno; Teixeira, José H; Vasconcelos, Daniel M; Santos, Susana G; Águas, Artur P; Barbosa, Mário A; Barbosa, Judite N
2018-06-01
The aim of this study was to investigate the effect chitosan (Ch) porous 3D scaffolds embedded with resolvin D1 (RvD1), an endogenous pro-resolving lipid mediator, on bone tissue healing. These scaffolds previous developed by us have demonstrated to have immunomodulatory properties namely in the modulation of the macrophage inflammatory phenotypic profile in an in vivo model of inflammation. Herein, results obtained in an in vivo rat femoral defect model demonstrated that two months after Ch + RvD1 scaffolds implantation, an increase in new bone formation, in bone trabecular thickness, and in collagen type I and Coll I/Coll III ratio were observed. These results suggest that Ch scaffolds embedded with RvD1 were able to lead to the formation of new bone with improvement of trabecular thickness. This study shows that the presence of RvD1 in the acute phase of the inflammatory response to the implanted biomaterial had a positive role in the subsequent bone tissue repair, thus demonstrating the importance of innovative approaches for the control of immune responses to biomedical implants in the design of advanced strategies for regenerative medicine. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1626-1633, 2018. © 2018 Wiley Periodicals, Inc.
International Nuclear Information System (INIS)
Ushenko, Yu A; Gorskii, M P; Dubolazov, A V; Motrich, A V; Ushenko, V A; Sidor, M I
2012-01-01
Theory of polarisation-correlation analysis of laser images of histological sections of biopsy material from cervix tissue based on spatial frequency selection of linear and circular birefringence mechanisms is formulated. Comparative results of measuring the coordinate distributions of the complex degree of mutual anisotropy (CDMA), produced by fibrillar networks formed by myosin and collagen fibres of cervix tissue in different pathological conditions, namely, pre-cancer (dysplasia) and cancer (adenocarcinoma), are presented. The values and variation ranges of statistical (moments of the first — fourth order), correlation (excess-autocorrelation functions), and fractal (slopes of approximating curves and dispersion of extrema of logarithmic dependences of power spectra) parameters of the CDMA coordinate distributions are studied. Objective criteria for pathology diagnostics and differentiation of its severity degree are determined. (image processing)
Fluorescence confocal polarizing microscopy
Indian Academy of Sciences (India)
Much of the modern understanding of orientational order in liquid crystals (LCs) is based on polarizing microscopy (PM). A PM image bears only two-dimensional (2D) information, integrating the 3D pattern of optical birefringence over the path of light. Recently, we proposed a technique to image 3D director patterns by ...
Fluorescence confocal polarizing microscopy: Three-dimensional ...
Indian Academy of Sciences (India)
Much of the modern understanding of orientational order in liquid crystals (LCs) is based on polarizing microscopy (PM). A PM image bears only two-dimensional (2D) information, integrating the 3D pattern of optical birefringence over the path of light. Recently, we proposed a technique to image 3D director patterns by ...
1D AND 2D NMR STUDIES OF BENZYL O–VANILLIN
Directory of Open Access Journals (Sweden)
Mohammed Hadi Al–Douh
2010-06-01
Full Text Available The reaction of o-vanillin A with benzyl bromide B2 in acetone as the solvent and K2CO3 as a base in the presence of tetra-n-butylammonium iodide (TBAI as catalyst formed benzyl o-vanillin, C. The complete assignments of C using PROTON, APT, DEPT-135, COSY, NOESY, HMQC and HMBC NMR in both CDCl3 and acetone-d6 are discussed, and the coupling constants J are reported in Hertz (Hz. Keywords: 1H NMR; 13C NMR; 2D NMR; Benzyl o-Vanillin
Cyclin K and cyclin D1b are oncogenic in myeloma cells
Directory of Open Access Journals (Sweden)
Renoir Jack-Michel
2010-05-01
Full Text Available Abstract Background Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM and always associated with mantle cell lymphoma (MCL. CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b. Both isoforms are present in MM cell lines and primary cells but their relative role in the tumorigenic process is still elusive. Results To test the tumorigenic potential of cyclin D1b in vivo, we generated cell clones derived from the non-CCND1 expressing MM LP-1 cell line, synthesizing either cyclin D1b or cyclin K, a structural homolog and viral oncogenic form of cyclin D1a. Immunocompromised mice injected s.c. with LP-1K or LP-1D1b cells develop tumors at the site of injection. Genome-wide analysis of LP-1-derived cells indicated that several cellular processes were altered by cyclin D1b and/or cyclin K expression such as cell metabolism, signal transduction, regulation of transcription and translation. Importantly, cyclin K and cyclin D1b have no major action on cell cycle or apoptosis regulatory genes. Moreover, they impact differently cell functions. Cyclin K-expressing cells have lost their migration properties and display enhanced clonogenic capacities. Cyclin D1b promotes tumorigenesis through the stimulation of angiogenesis. Conclusions Our study indicates that cyclin D1b participates into MM pathogenesis via previously unrevealed actions.
Westwood, Melissa; Al-Saghir, Khiria; Finn-Sell, Sarah; Tan, Cherlyn; Cowley, Elizabeth; Berneau, Stéphane; Adlam, Daman; Johnstone, Edward D
2017-12-01
Failure of trophoblast invasion and remodelling of maternal blood vessels leads to the pregnancy complication pre-eclampsia (PE). In other systems, the sphingolipid, sphingosine-1-phosphate (S1P), controls cell migration therefore this study determined its effect on extravillous trophoblast (EVT) function. A transwell migration system was used to assess the behaviour of three trophoblast cell lines, Swan-71, SGHPL-4, and JEG3, and primary human trophoblasts in the presence or absence of S1P, S1P pathway inhibitors and 1,25(OH) 2 D 3 . QPCR and immunolocalisation were used to demonstrate EVT S1P receptor expression. EVTs express S1P receptors 1, 2 and 3. S1P inhibited EVT migration. This effect was abolished in the presence of the specific S1PR2 inhibitor, JTE-013 (p S1P alone) whereas treatment with the S1R1/3 inhibitor, FTY720, had no effect. In other cell types S1PR2 is regulated by vitamin D; here we found that treatment with 1,25(OH) 2 D 3 for 48 or 72 h reduces S1PR2 (4-fold; S1P did not inhibit the migration of cells exposed to 1,25(OH) 2 D 3 (p S1P receptor isoforms, S1P predominantly signals through S1PR2/Gα 12/13 to activate Rho and thereby acts as potent inhibitor of EVT migration. Importantly, expression of S1PR2, and therefore S1P function, can be down-regulated by vitamin D. Our data suggest that vitamin D deficiency, which is known to be associated with PE, may contribute to the impaired trophoblast migration that underlies this condition. Copyright © 2017 Elsevier Ltd. All rights reserved.
Navon, M. I.; Stefanescu, R.; Fuelberg, H. E.; Marchand, M.
2012-12-01
NASA's launch of the GOES-R Lightning Mapper (GLM) in 2015 will provide continuous, full disc, high resolution total lightning (IC + CG) data. The data will be available at a horizontal resolution of approximately 9 km. Compared to other types of data, the assimilation of lightning data into operational numerical models has received relatively little attention. Previous efforts of lightning assimilation mostly have employed nudging. This paper will describe the implementation of 1D+3D/4D Var assimilation schemes of existing ground-based WTLN (Worldwide Total Lightning Network) lightning observations using non-linear observation operators in the incremental WRFDA system. To mimic the expected output of GLM, the WTLN data were used to generate lightning super-observations characterized by flash rates/81 km2/20 min. A major difficulty associated with variational approaches is the complexity of the observation operator that defines the model equivalent of lightning. We use Convective Available Potential Energy (CAPE) as a proxy between lightning data and model variables. This operator is highly nonlinear. Marecal and Mahfouf (2003) have shown that nonlinearities can prevent direct assimilation of rainfall rates in the ECMWF 4D-VAR (using the incremental formulation proposed by Courtier et al. (1994)) from being successful. Using data from the 2011 Tuscaloosa, AL tornado outbreak, we have proved that the direct assimilation of lightning data into the WRF 3D/4D - Var systems is limited due to this incremental approach. Severe threshold limits must be imposed on the innovation vectors to obtain an improved analysis. We have implemented 1D+3D/4D Var schemes to assimilate lightning observations into the WRF model. Their use avoids innovation vector constrains from preventing the inclusion of a greater number of lightning observations Their use also minimizes the problem that nonlinearities in the moist convective scheme can introduce discontinuities in the cost function
International Nuclear Information System (INIS)
Waddington, J.L.; Mashurano, M.; Molloy, A.G.; O'Boyle, K.M.
1986-01-01
The purposes of this article are to describe the properties of some newer selective D 1 agents, and to characterize behavioral responses to a D 1 agonist in the intact adult rat. R- and S-SKandF 83566 and other new 1-phenyl-1H-3-benzazephines as selective D 1 agents are discussed. The displacement of 3 H-SCH 23390 from human brain D 1 receptors, in comparison with displacement of 3 H-piflutixol and 3 H-spiperone is shown. Enantiomeric induction of grooming and other behaviors by R- and S-SKandF 38393 is examined. Sections are also devoted to pharmacological characterization of behavioral responses to SKandF 38393 and to D 1 : D 2 receptor systems and the regulation of dopaminergic behaviors
On the physiological role of 1,24,25-trihydroxyvitamin D/sub 3/
Energy Technology Data Exchange (ETDEWEB)
Castillo, L. (Univ. of Wisconsin, Madison); Tanaka, Y.; DeLuca, H.F.; Ikekawa, N.
1978-01-01
The extent, onset and duration of the biological activity of 1,24(R),25-trihydroxyvitamin D/sub 3/, 1,24(S),25-trihydroxyvitamin D/sub 3/ has been compared with that of 1,25-dihydroxyvitamin D/sub 3/ in the elevation of serum phosphorus, healing of rickets, stimulation of intestinal calcium transport, mobilization of calcium from bone in vitamin D-deficient rats and induction 25-hydroxyvitamin D/sub 3/-24-hydroxylase in chickens. The 1,24,25-trihydroxyvitamin D/sub 3/ S and R isomers are approximately equal in activity but both are less active than 1,25-dihydroxyvitamin D/sub 3/. In some systems their duration of activity is also less than that of 1,25-dihydroxyvitamin D/sub 3/. The time course of response to the 3 forms of vitamin D is approximately equal. These results strongly suggest that 1,24(R),25-trihydroxyvitamin D/sub 3/ is not a further activation product of 1,25-dihydroxyvitamin D/sub 3/, but is likely a product leading to inactivation.
Waiting time distribution in M/D/1 queueing systems
DEFF Research Database (Denmark)
Iversen, Villy Bæk; Staalhagen, Lars
1999-01-01
The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...
KCNE1 D85N polymorphism — a sex-specific modifier in type 1 long QT syndrome?
Directory of Open Access Journals (Sweden)
Marjamaa Annukka
2011-01-01
Full Text Available Abstract Background Long QT syndrome (LQTS is an inherited ion channel disorder manifesting with prolongation of the cardiac repolarization phase and severe ventricular arrhythmias. The common KCNE1 D85N potassium channel variant prolongs QT interval by inhibiting IKs (KCNQ1 and IKr (KCNH2 currents and is therefore a suitable candidate for a modifier gene in LQTS. Methods We studied the effect of D85N on age-, sex-, and heart rate-adjusted QT-interval duration by linear regression in LQTS patients carrying the Finnish founder mutations KCNQ1 G589D (n = 492, KCNQ1 IVS7-2A>G (n = 66, KCNH2 L552S (n = 73, and KCNH2 R176W (n = 88. We also investigated the association between D85N and clinical variables reflecting the severity of the disease. Results D85N was associated with a QT prolongation by 26 ms (SE 8.6, p = 0.003 in males with KCNQ1 G589D (n = 213, but not in females with G589D (n = 279. In linear regression, the interaction between D85N genotype and sex was significant (p = 0.028. Within the KCNQ1 G589D mutation group, KCNE1 D85N carriers were more often probands of the family (p = 0.042 and were more likely to use beta blocker medication (p = 0.010 than non-carriers. The number of D85N carriers in other founder mutation groups was too small to assess its effects. Conclusions We propose that KCNE1 D85N is a sex-specific QT-interval modifier in type 1 LQTS and may also associate with increased severity of disease. Our data warrant additional studies on the role of KCNE1 D85N in other genetically homogeneous groups of LQTS patients.
Haraguchi, Norihisa; Kaseda, Jun; Nakayama, Yasumune; Nagahama, Kazuhiro; Ogawa, Takahira; Matsuoka, Masayoshi
2018-06-08
Photosystem II complex embedded in thylakoid membrane performs oxygenic photosynthesis where the reaction center D1/D2 heterodimer accommodates all components of the electron transport chain. To express thermostable D1/D2 heterodimer in a cyanobacterium Synechococcus elongatus PCC 7942, we constructed a series of mutant strains whose psbA1 and psbD1 genes encoding, respectively, the most highly expressed D1 and D2 polypeptides were replaced with those of a thermophilic strain, Thermosynechococcus vulcanus. Because the C-terminal 16 amino acid sequences of D1 polypeptides should be processed prior to maturation but diverge from each other, we also constructed the psbA1ΔC-replaced strain expressing a thermostable D1 polypeptide devoid of the C-terminal extension. The psbA1/psbD1-replaced strain showed decreased growth rate and oxygen evolution rate, suggesting inefficient photosystem II. Immunoblot analyses for thermostable D1, D2 polypeptides revealed that the heterologous D1 protein was absent in thylakoid membrane from any mutant strains with psbA1, psbA1ΔC, and psbA1/psbD1-replacements, whereas the heterologous D2 protein was present in thylakoid membrane as well as purified photosystem II complex from the psbA1/psbD1-replaced strain. In the latter strain, the compensatory expression of psbA3 and psbD2 genes was elevated. These data suggest that heterologous D2 polypeptide could be combined with the host D1 polypeptide to form chimeric D1/D2 heterodimer, whereas heterologous D1 polypeptide even without the C-terminal extension was unable to make complex with the host D2 polypeptide. Since the heterologous D1 could not be detected even in the whole cells of psbA1/psbD1-replaced strain, the rapid degradation of unprocessed or unassembled heterologous D1 was implicated. Copyright © 2018 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.
Sempos, Christopher T; Heijboer, Annemieke C; Bikle, Daniel D; Bollerslev, Jens; Bouillon, Roger; Brannon, Patsy M; DeLuca, Hector F; Jones, Glenville; Munns, Craig F; Bilezikian, John P; Giustina, Andrea; Binkley, Neil
2018-05-31
The 1st International Conference on Controversies in Vitamin D was held in Pisa, Italy June 14-16, 2017. The meeting's purpose was to address controversies in vitamin D research, review data available to help resolve them and suggest a research agenda to clarify areas of uncertainty. Serum 25-hydroxyvitamin D (25 (OH)D) concentration, i.e., the sum of 25 (OH)D 3 and 25 (OH)D 2 , remains the critical measurement for defining vitamin D status. Assay variation for 25 (OH) D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop consensus on vitamin D status is that measurement of 25 (OH) D and, in the future, other potential vitamin D biomarkers, e.g., 1α,25 (OH) 2 D 3 , 3-epi-25 (OH) D, 24,25 (OH) 2 D 3, vitamin D binding protein (DBP), free/bioavailable 25 (OH) D and parathyroid hormone be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program (VDSP) tools are described and recommended for standardizing 25 (OH) D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology (NIST) Standard Reference Materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25 (OH) D values below 12 ng/mL (30 nmol/L) should be considered to be associated with an increased risk of rickets/osteomalacia while 25 (OH) D concentrations between 20-50 ng/mL (50-125 nmol/L) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed. This article is protected by copyright. All rights reserved.
International Nuclear Information System (INIS)
Govil, Karan; Gunaydin, Murat
2013-01-01
Quantization of the geometric quasiconformal realizations of noncompact groups and supergroups leads directly to their minimal unitary representations (minreps). Using quasiconformal methods massless unitary supermultiplets of superconformal groups SU(2,2|N) and OSp(8 ⁎ |2n) in four and six dimensions were constructed as minreps and their U(1) and SU(2) deformations, respectively. In this paper we extend these results to SU(2) deformations of the minrep of N=4 superconformal algebra D(2,1;λ) in one dimension. We find that SU(2) deformations can be achieved using n pair of bosons and m pairs of fermions simultaneously. The generators of deformed minimal representations of D(2,1;λ) commute with the generators of a dual superalgebra OSp(2n ⁎ |2m) realized in terms of these bosons and fermions. We show that there exists a precise mapping between symmetry generators of N=4 superconformal models in harmonic superspace studied recently and minimal unitary supermultiplets of D(2,1;λ) deformed by a pair of bosons. This can be understood as a particular case of a general mapping between the spectra of quantum mechanical quaternionic Kähler sigma models with eight super symmetries and minreps of their isometry groups that descends from the precise mapping established between the 4d, N=2 sigma models coupled to supergravity and minreps of their isometry groups.
MEASUREMENT OF THE B0 ---> D*- A+(1) BRANCHING FRACTION WITH PARTIALLY RECONSTRUCTED D*
Energy Technology Data Exchange (ETDEWEB)
Salvatore, Pasquale F
2002-07-26
The B{sup 0} {yields} D*{sup -} a{sub 1}{sup +} branching fraction has been measured with data collected by the BaBar experiment in 1999 and 2000 corresponding to a total integrated luminosity of 20.6 fb{sup -1}. Signal events have been selected using a partial reconstruction technique, in which only the a{sub 1}{sup +} and the slow pion ({pi}{sub s}) from the D*{sup -} decay are identified. A signal yield of 18400 {+-} 1200 events has been found, corresponding to a preliminary branching fraction of (1.20 {+-} 0.07(stat) {+-} 0.14(syst))%.
In vivo 1D and 2D correlation MR spectroscopy of the soleus muscle at 7T
Ramadan, Saadallah; Ratai, Eva-Maria; Wald, Lawrence L.; Mountford, Carolyn E.
2010-05-01
AimThis study aims to (1) undertake and analyse 1D and 2D MR correlation spectroscopy from human soleus muscle in vivo at 7T, and (2) determine T1 and T2 relaxation time constants at 7T field strength due to their importance in sequence design and spectral quantitation. MethodSix healthy, male volunteers were consented and scanned on a 7T whole-body scanner (Siemens AG, Erlangen, Germany). Experiments were undertaken using a 28 cm diameter detunable birdcage coil for signal excitation and an 8.5 cm diameter surface coil for signal reception. The relaxation time constants, T1 and T2 were recorded using a STEAM sequence, using the 'progressive saturation' method for the T1 and multiple echo times for T2. The 2D L-Correlated SpectroscopY (L-COSY) method was employed with 64 increments (0.4 ms increment size) and eight averages per scan, with a total time of 17 min. ResultsT1 and T2 values for the metabolites of interest were determined. The L-COSY spectra obtained from the soleus muscle provided information on lipid content and chemical structure not available, in vivo, at lower field strengths. All molecular fragments within multiple lipid compartments were chemically shifted by 0.20-0.26 ppm at this field strength. 1D and 2D L-COSY spectra were assigned and proton connectivities were confirmed with the 2D method. ConclusionIn vivo 1D and 2D spectroscopic examination of muscle can be successfully recorded at 7T and is now available to assess lipid alterations as well as other metabolites present with disease. T1 and T2 values were also determined in soleus muscle of male healthy volunteers.
1,25-Dihydroxyvitamin D3 Treatment Shrinks Uterine Leiomyoma Tumors in the Eker Rat Model1
Halder, Sunil K.; Sharan, Chakradhari; Al-Hendy, Ayman
2012-01-01
ABSTRACT Uterine leiomyomas (fibroids) are the most common benign tumors in women of reproductive age. These tumors are three to four times more prevalent in African American women, who also have a 10 times higher incidence of hypovitaminosis D than white women. Recent studies have demonstrated the antitumor effects of 1,25-dihydroxyvitamin D3 on several cancers, but its effects on uterine leiomyomas are still unknown. To determine the antitumor and therapeutic effects of 1,25-dihydroxyvitamin D3 on uterine leiomyomas, female Eker rats (14–16 mo old) harboring uterine leiomyomas were randomized into control and experimental groups and were given vehicle versus 1,25-dihydroxyvitamin D3 (0.5 μg/kg per day) subcutaneously for 3 wk, respectively. At the end of the experiment, the rats were euthanized, and the leiomyoma tumors were analyzed. Treatment with 1,25-dihydroxyvitamin D3 significantly reduced leiomyoma tumor size in Eker rats. It also reduced leiomyoma size by suppressing cell growth and proliferation-related genes (Pcna, cyclin D1 [Ccnd1], Myc, Cdk1, Cdk2, and Cdk4), antiapoptotic genes (Bcl2 and Bcl2l1 [Bcl-x]), and estrogen and progesterone receptors. Additionally, immunohistochemistry revealed decreased expression of PCNA and MKI67 (a marker of proliferation) and increased expression of caspase 3 in 1,25-dihydroxyvitamin D3-treated Eker rat leiomyomas. Toxicity analyses using serum samples showed similar levels of SGOT, SGPT, calcium, and total bilirubin in 1,25-dihydroxyvitamin D3-treated and vehicle-treated control Eker rats. These results support that 1,25-dihydroxyvitamin D3 is an antitumor agent that may be a potential safe, nonsurgical therapeutic option for the treatment of uterine leiomyomas. PMID:22302692
Review of Zero-D and 1-D Models of Blood Flow in the Cardiovascular System
2011-01-01
Background Zero-dimensional (lumped parameter) and one dimensional models, based on simplified representations of the components of the cardiovascular system, can contribute strongly to our understanding of circulatory physiology. Zero-D models provide a concise way to evaluate the haemodynamic interactions among the cardiovascular organs, whilst one-D (distributed parameter) models add the facility to represent efficiently the effects of pulse wave transmission in the arterial network at greatly reduced computational expense compared to higher dimensional computational fluid dynamics studies. There is extensive literature on both types of models. Method and Results The purpose of this review article is to summarise published 0D and 1D models of the cardiovascular system, to explore their limitations and range of application, and to provide an indication of the physiological phenomena that can be included in these representations. The review on 0D models collects together in one place a description of the range of models that have been used to describe the various characteristics of cardiovascular response, together with the factors that influence it. Such models generally feature the major components of the system, such as the heart, the heart valves and the vasculature. The models are categorised in terms of the features of the system that they are able to represent, their complexity and range of application: representations of effects including pressure-dependent vessel properties, interaction between the heart chambers, neuro-regulation and auto-regulation are explored. The examination on 1D models covers various methods for the assembly, discretisation and solution of the governing equations, in conjunction with a report of the definition and treatment of boundary conditions. Increasingly, 0D and 1D models are used in multi-scale models, in which their primary role is to provide boundary conditions for sophisticate, and often patient-specific, 2D and 3D models
Hoenderop, J.G.J.; Dardenne, O.; Abel, M. van; Kemp, J.W.C.M. van der; Os, C.H. van; Arnaud, R. St.; Bindels, R.J.M.
2002-01-01
Pseudovitamin D-deficiency rickets (PDDR) is an autosomal disease characterized by hyperparathyroidism, rickets, and undetectable levels of 1,25-dihydroxyvitaminD3 (1,25(OH)2D3). Mice in which the 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-OHase) gene was inactivated presented the same clinical
Arnt, J
1985-08-26
The effects of DA agonists and antagonists with different dopamine (DA) D-1 and D-2 receptor selectivity have been studied in rats with bilateral 6-OHDA lesions. The D-1 agonist SK & F 38393, the D-2 agonist pergolide and the mixed agonist apomorphine all induced marked hyperactivity in lesioned rats in doses which were without stimulant effect in sham-operated animals. The hyperactivity induced by SK & F 38393 was blocked by the DA D-1 antagonist SCH 23390, but unaffected by the D-2 antagonists spiroperidol or clebopride. Pergolide-induced hyperactivity showed the reverse selectivity. The mixed D-1/D-2 antagonists, cis(Z)-flupentixol and cis(Z)-clopenthixol, however blocked the effect of both agonists. Apomorphine-induced hyperactivity was neither blocked by selective D-1 nor D-2 antagonists, but was dose-dependently inhibited by cis(Z)-flupentixol and cis(Z)-clopenthixol. Potent blockade was also obtained by combined treatment with SCH 23390 and spiroperidol, indicating the need of blocking both D-1 and D-2 receptors simultaneously. The results indicate that D-1 and D-2 receptor function can be independently manipulated in denervated rats and they confirm similar results obtained in rats with unilateral 6-OHDA lesions using circling behaviour.
Energy Technology Data Exchange (ETDEWEB)
Marinot, R; Wallet, Ph [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires
1960-07-01
Test pieces of steel were irradiated in the reactor G1 at Marcoule, in convectors replacing fuel elements, and in vertical channels in furnace-heated containers. The apparatus designed for this irradiation is described: containers, converter-rods, suspension fixtures and clamps, temperature measurement devices, lead castles and unloading set-ups. (author) [French] Des eprouvettes d'acier ont ete irradiees dans le reacteur G1 de Marcoule dans des convertisseurs mis a la place d'elements combustibles, et dans des canaux verticaux, en conteneurs chauffes par four. Nous decrivons l'appareillage etudie pour cette irradiation: conteneurs, barreaux-convertisseurs, dispositifs de suspension et d'amarrage, dispositifs de regulation et de mesure de temperature, chateaux de plomb et montages de defournement. (auteur)
Diffusion and particle mobility in 1D system
International Nuclear Information System (INIS)
Borman, V.D.; Johansson, B.; Skorodumova, N.V.; Tronin, I.V.; Tronin, V.N.; Troyan, V.I.
2006-01-01
The transport properties of one-dimensional (1D) systems have been studied theoretically. Contradictory experimental results on molecular transport in quasi-1D systems, such as zeolite structures, when both diffusion transport acceleration and the existence of the diffusion mode with lower particle mobility (single-file diffusion ( 2 >∼t 1/2 )) have been reported, are consolidated in a consistent model. Transition from the single-file diffusion mode to an Einstein-like diffusion 2 >∼t with diffusion coefficient increasing with the density has been predicted to occur at large observation times
Thomsen, Morgane; Caine, Simon Barak
2016-04-05
Muscarinic and dopamine brain systems interact intimately, and muscarinic receptor ligands, like dopamine ligands, can modulate the reinforcing and discriminative stimulus (S(D)) effects of cocaine. To enlighten the dopamine/muscarinic interactions as they pertain to the S(D) effects of cocaine, we evaluated whether muscarinic M1, M2 or M4 receptors are necessary for dopamine D1 and/or D2 antagonist mediated modulation of the S(D) effects of cocaine. Knockout mice lacking M1, M2, or M4 receptors, as well as control wild-type mice and outbred Swiss-Webster mice, were trained to discriminate 10mg/kg cocaine from saline in a food-reinforced drug discrimination procedure. Effects of pretreatments with the dopamine D1 antagonist SCH 23390 and the dopamine D2 antagonist eticlopride were evaluated. In intact mice, both SCH 23390 and eticlopride attenuated the cocaine discriminative stimulus effect, as expected. SCH 23390 similarly attenuated the cocaine discriminative stimulus effect in M1 knockout mice, but not in mice lacking M2 or M4 receptors. The effects of eticlopride were comparable in each knockout strain. These findings demonstrate differences in the way that D1 and D2 antagonists modulate the S(D) effects of cocaine, D1 modulation being at least partially dependent upon activity at the inhibitory M2/M4 muscarinic subtypes, while D2 modulation appeared independent of these systems. Copyright © 2016 Elsevier B.V. All rights reserved.
1D Piezoelectric Material Based Nanogenerators: Methods, Materials and Property Optimization.
Li, Xing; Sun, Mei; Wei, Xianlong; Shan, Chongxin; Chen, Qing
2018-03-23
Due to the enhanced piezoelectric properties, excellent mechanical properties and tunable electric properties, one-dimensional (1D) piezoelectric materials have shown their promising applications in nanogenerators (NG), sensors, actuators, electronic devices etc. To present a clear view about 1D piezoelectric materials, this review mainly focuses on the characterization and optimization of the piezoelectric properties of 1D nanomaterials, including semiconducting nanowires (NWs) with wurtzite and/or zinc blend phases, perovskite NWs and 1D polymers. Specifically, the piezoelectric coefficients, performance of single NW-based NG and structure-dependent electromechanical properties of 1D nanostructured materials can be respectively investigated through piezoresponse force microscopy, atomic force microscopy and the in-situ scanning/transmission electron microcopy. Along with the introduction of the mechanism and piezoelectric properties of 1D semiconductor, perovskite materials and polymers, their performance improvement strategies are summarized from the view of microstructures, including size-effect, crystal structure, orientation and defects. Finally, the extension of 1D piezoelectric materials in field effect transistors and optoelectronic devices are simply introduced.
Directory of Open Access Journals (Sweden)
Ramesh eChandra
2013-05-01
Full Text Available Exposure to psychostimulants results in structural and synaptic plasticity in striatal medium spiny neurons (MSNs. These cellular adaptations arise from alterations in genes that are highly implicated in the rearrangement of the actin cytoskeleton, such as Tiam1. Previous studies have demonstrated a crucial role for dopamine receptor 1 (D1-containing striatal MSNs in mediating psychostimulant induced plasticity changes. These D1-MSNs in the nucleus accumbens (NAc positively regulate drug seeking, reward, and locomotor behavioral effects as well as the morphological adaptations of psychostimulant drugs. Here, we demonstrate that rats that actively self-administer cocaine display reduced levels of Tiam1 in the NAc. To further examine the cell type specific contribution to these changes in Tiam1 we used optogenetics to selectively manipulate NAc D1-MSNs or dopamine receptor 2 (D2 expressing MSNs. We find that repeated ChR2 activation of D1-MSNs but not D2-MSNs caused a down-regulation of Tiam1 levels similar to the effects of cocaine. Further, activation of D2-MSNs, which caused a late blunted cocaine-mediated locomotor behavioral response, did not alter Tiam1 levels. We then examined the contribution of D1-MSNs to the cocaine-mediated decrease of Tiam1. Using the light activated chloride pump, eNpHR3.0, we selectively inhibited D1-MSNs during cocaine exposure, which resulted in a behavioral blockade of cocaine-induced locomotor sensitization. Moreover, inhibiting these NAc D1-MSNs during cocaine exposure reversed the down-regulation of Tiam1 gene expression and protein levels. These data demonstrate that altering activity in specific neural circuits with optogenetics can impact the underlying molecular substrates of psychostimulant mediated behavior and function.
Mosquera, Ricardo A.; Rios, Miguel A.; Tovar, Clara A.; Maestro, Miguel
1989-10-01
The conformational analysis of vitamin D 3 derivatives, including the biologically active form 1α,25-dihydroxyvitamin D 3 (III) and several synthetic analogues: b-deoxy-1α,25-dihydroxyvitamin D 3 (IV), 3-deoxy-3α-methyl-1α,25-dihydroxyvitamin D 3 (V), 3-deoxy-3β-methyl-1α,25-dihydroxyvitamin D 3 (VI), and 3-deoxy-3,3-dimethyl-1α,25-dihydroxyvitamin D 3 (VII), has been carried out employing Allinger's molecular mechanics method. The results obtained for conformational equilibrium populations are found to be in good agreement with those provided by NMR studies. Comparison of the active form of vitamin D 3 (1α,25-dihydroxyvitamin D 3) with the other species reveals no important geometrical differences.
Byrnes, E M; Bruno, J P
1994-09-01
The D1- and D2-mediation of stimulated motor behavior was studied in pups (Days 10-11) and weanlings (Days 20-21) that had been depleted of dopamine (DA) on postnatal Day 3. Administration of the D1-like agonist SKF 38393 (30.0 mg/kg) or the D2-like agonist quinpirole (3.0 mg/kg) increased the incidence of sniffing and locomotion in intact and DA-depleted animals tested at either age. However, the ability of selective DA antagonists to reduce these stimulated responses interacted with both the depletion and the age at the time of testing. When tested as pups, both the D1 antagonist SCH 23390 (0.2 or 0.4 mg/kg) and the D2 antagonist clebopride (10.0 mg/kg) suppressed the behaviors induced by either class of DA agonist. When tested as weanlings, intact animals exhibited the profile of pups (i.e., either antagonist blocked each agonist). In DA-depleted weanlings, however, only the D1 antagonist blocked the D1 agonist-induced responses and only the D2 antagonist blocked the D2 agonist-induced responses. These data demonstrate that the interactions between D1 and D2 receptors in the expression of stimulated motor behaviors are altered following DA depletions in neonates. Moreover, this change in receptor function occurs sometime between 7 and 13 days after the DA depletion.
Anti-cytokine therapies in T1D
DEFF Research Database (Denmark)
Nepom, Gerald T; Ehlers, Mario; Mandrup-Poulsen, Thomas
2013-01-01
Therapeutic targeting of proinflammatory cytokines is clinically beneficial in several autoimmune disorders. Several of these cytokines are directly implicated in the pathogenesis of type 1 diabetes, suggesting opportunities for design of clinical trials in type 1 diabetes that incorporate select...... suitable for modulating the immune response in T1D....
Transverse magnetic field impact on waveguide modes of photonic crystals.
Sylgacheva, Daria; Khokhlov, Nikolai; Kalish, Andrey; Dagesyan, Sarkis; Prokopov, Anatoly; Shaposhnikov, Alexandr; Berzhansky, Vladimir; Nur-E-Alam, Mohammad; Vasiliev, Mikhail; Alameh, Kamal; Belotelov, Vladimir
2016-08-15
This Letter presents a theoretical and experimental study of waveguide modes of one-dimensional magneto-photonic crystals magnetized in the in-plane direction. It is shown that the propagation constants of the TM waveguide modes are sensitive to the transverse magnetization and the spectrum of the transverse magneto-optical Kerr effect has resonant features at mode excitation frequencies. Two types of structures are considered: a non-magnetic photonic crystal with an additional magnetic layer on top and a magneto-photonic crystal with a magnetic layer within each period. We found that the magneto-optical non-reciprocity effect is greater in the first case: it has a magnitude of δ∼10-4, while the second structure type demonstrates δ∼10-5 only, due to the higher asymmetry of the claddings of the magnetic layer. Experimental observations show resonant features in the optical and magneto-optical Kerr effect spectra. The measured dispersion properties are in good agreement with the theoretical predictions. An amplitude of light intensity modulation of up to 2.5% was observed for waveguide mode excitation within the magnetic top layer of the non-magnetic photonic crystal structure. The presented theoretical approach may be utilized for the design of magneto-optical sensors and modulators requiring pre-determined spectral features.
Energy Technology Data Exchange (ETDEWEB)
He, Jun [Nanjing Normal University, Department of Physics and Institute of Theoretical Physics, Nanjing (China); Chen, Dian-Yong [Southeast University, School of Physics, Nanjing (China)
2017-06-15
Invoked by the recent observation of Y(4390) at BESIII, which is about 40 MeV below the D*(2010) anti D{sub 1}(2420) threshold, we investigate possible bound and resonance states from the D*(2010) anti D{sub 1}(2420) interaction with the one-boson-exchange model in a quasipotential Bethe-Salpeter equation approach. A bound state with quantum number 0{sup -}(1{sup --}) is produced at 4384 MeV from the D*(2010) anti D{sub 1}(2420) interaction, which can be related to experimentally observed Y(4390). Another state with quantum number 1{sup +}(1{sup +}) is also produced at 4461 + i39 MeV from this interaction. Different from the 0{sup -}(1{sup --}) state, the 1{sup +}(1{sup +}) state is a resonance state above the D*(2010) anti D{sub 1}(2420) threshold. This resonance state can be related to the first observed charged charmonium-like state Z(4430), which has a mass about 4475 MeV measured above the threshold as observed at Belle and LHCb. Our result suggests that Y(4390) is an isoscalar partner of the Z(4430) as a hadronic-molecular state from the D*(2010) anti D{sub 1}(2420) interaction. (orig.)
Coupling of Nod1D and HOTCHANNEL: static case; Acoplamiento de Nod1D y HOTCHANNEL: caso estatico
Energy Technology Data Exchange (ETDEWEB)
Gomez T, A.M. [IPN-ESFM, 07738 Mexico D.F. (Mexico); Ovando C, R. [IIE-Gcia. de Energia Nuclear, Cuernavaca, Morelos (Mexico)]. e-mail: rovando@iie.org.mx
2003-07-01
In this work the joining of the programs Nod1D and HOTCHANNEL, developed in the National Polytechnic Institute (IPN) and in the Electrical Research Institute (IIE) respectively is described. The first one allows to study the neutronic of a nuclear reactor and the second one allows to carry out the analysis of hot channel of a Boiling Water Reactor (BWR). Nod1 D is a program that it solves by nodal methods type finite element those diffusion equations in multigroup, and it is the static part of Nod Kin that it solves the diffusion equation in their time dependent part. For another side HOTCHANNEL is based on a mathematical model constituted by four conservation equations (two of mass conservation, one of motion quantity and one of energy), which are solved applying one discretization in implicit finite differences. Both programs have been verified in independent form using diverse test problems. In this work the modifications that were necessary to carry out to both for obtaining a coupled program that it provides the axial distribution of the neutron flux, the power, the burnup and the void fraction, among others parameters as much as neutronic as thermal hydraulics are described. Those are also mentioned limitations, advantages and disadvantages of the final product to which has been designated Nod1 D-HotChn. Diverse results for the Cycle 1 of the Laguna Verde Unit 1 reactor of the Nucleo electric central comparing them with those obtained directly with the CoreMasterPresto code are provided. (Author)
International Nuclear Information System (INIS)
West, W.P.; Evans, T.E.; Brooks, N.H.
1996-10-01
NEWT1D, a one dimensional multifluid model of the scrape-off layer and divertor plasma, has been used to model the plasma including the distribution of carbon ionization states in the SOL and divertor of ELMing H-mode at two injected power levels in DIII-D. Comparison of the code predictions to the measured divertor and scrape-off layer (SOL) plasma density and temperature shows good agreement. Comparison of the predicted line emissions to the spectroscopic data suggests that physically sputtered carbon from the strike point is not transported up the flux tube; a distributed source of carbon a few centimeters up the flux tube is required to achieve reasonable agreement
Cao, Jing; Poumellec, Bertrand; Brisset, François; Lancry, Matthieu
2018-03-19
Femtosecond laser-induced refractive index changes in lithium niobium silicate glass were explored at high repetition rate (300 fs, 500 kHz) by polarized light microscopy, full-wave retardation plate, quantitative birefringence microscopy, and digital holographic microscopy. We found three regimes on energy increase. The first one corresponds to isotropic negative refractive index change (for pulse energy ranging 0.4-0.8 μJ/pulse, 0.6 NA, 5μm/s, 650μm focusing depth in the glass). The second one (0.8-1.2 μJ/pulse) corresponds to birefringence with well-defined slow axis orientation. The third one (above 1.2 μJ/pulse) is related to birefringence direction fluctuation. Interestingly, these regimes are consistent with crystallization ones. In addition, an asymmetric orientational writing effect has been detected on birefringence. These topics extend the possibility of controlling refractive index change in multi-component glasses.
Directory of Open Access Journals (Sweden)
Melissa L Perreault
Full Text Available In basal ganglia a significant subset of GABAergic medium spiny neurons (MSNs coexpress D1 and D2 receptors (D1R and D2R along with the neuropeptides dynorphin (DYN and enkephalin (ENK. These coexpressing neurons have been recently shown to have a region-specific distribution throughout the mesolimbic and basal ganglia circuits. While the functional relevance of these MSNs remains relatively unexplored, they have been shown to exhibit the unique property of expressing the dopamine D1-D2 receptor heteromer, a novel receptor complex with distinct pharmacology and cell signaling properties. Here we showed that MSNs coexpressing the D1R and D2R also exhibited a dual GABA/glutamate phenotype. Activation of the D1R-D2R heteromer in these neurons resulted in the simultaneous, but differential regulation of proteins involved in GABA and glutamate production or vesicular uptake in the nucleus accumbens (NAc, ventral tegmental area (VTA, caudate putamen and substantia nigra (SN. Additionally, activation of the D1R-D2R heteromer in NAc shell, but not NAc core, differentially altered protein expression in VTA and SN, regions rich in dopamine cell bodies. The identification of a MSN with dual inhibitory and excitatory intrinsic functions provides new insights into the neuroanatomy of the basal ganglia and demonstrates a novel source of glutamate in this circuit. Furthermore, the demonstration of a dopamine receptor complex with the potential to differentially regulate the expression of proteins directly involved in GABAergic inhibitory or glutamatergic excitatory activation in VTA and SN may potentially provide new insights into the regulation of dopamine neuron activity. This could have broad implications in understanding how dysregulation of neurotransmission within basal ganglia contributes to dopamine neuronal dysfunction.
Data of evolutionary structure change: 1ONAD-2D3RD [Confc[Archive
Lifescience Database Archive (English)
Full Text Available 1ONAD-2D3RD 1ONA 2D3R D D ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAK...WNMQNGKVGTAHIIYNSVDKRLSAVVSYPNADSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLK------TNALHFMFNQFSKDQKDLILQGDAT...n> 1ONA D 1ONAD TRVS
Data of evolutionary structure change: 1ONAD-2D3PD [Confc[Archive
Lifescience Database Archive (English)
Full Text Available 1ONAD-2D3PD 1ONA 2D3P D D ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAK...WNMQNGKVGTAHIIYNSVDKRLSAVVSYPNADSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKT------NALHFMFNQFSKDQKDLILQGDAT.../entryChain> 1ONA D 1ONAD
Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration.
Kim, Kang-Hyun; Park, Tai Sun; Kim, You-Sun; Lee, Jae Seung; Oh, Yeon-Mok; Lee, Sang-Do; Lee, Sei Won
2016-01-01
Emphysema is an irreversible disease that is characterized by destruction of lung tissue as a result of inflammation caused by smoking. Resolvin D1 (RvD1), derived from docosahexaenoic acid, is a novel lipid that resolves inflammation. The present study tested whether RvD1 prevents smoking-induced emphysema and promotes lung tissue regeneration. C57BL/6 mice, 8 weeks of age, were randomly divided into four groups: control, RvD1 only, smoking only, and smoking with RvD1 administration. Four different protocols were used to induce emphysema and administer RvD1: mice were exposed to smoking for 4 weeks with poly(I:C) or to smoking only for 24 weeks, and RvD1 was injected within the smoking exposure period to prevent regeneration or after completion of smoking exposure to assess regeneration. The mean linear intercept and inflammation scores were measured in the lung tissue, and inflammatory cells and cytokines were measured in the bronchoalveolar lavage fluid. Measurements of mean linear intercept showed that RvD1 significantly attenuated smoking-induced lung destruction in all emphysema models. RvD1 also reduced smoking-induced inflammatory cell infiltration, which causes the structural derangements observed in emphysema. In the 4-week prevention model, RvD1 reduced the smoking-induced increase in eosinophils and interleukin-6 in the bronchoalveolar lavage fluid. In the 24-week prevention model, RvD1 also reduced the increased neutrophils and total cell counts induced by smoking. RvD1 attenuated smoking-induced emphysema in vivo by reducing inflammation and promoting tissue regeneration. This result suggests that RvD1 may be useful in the prevention and treatment of emphysema.
Ashton, Gary
Commercial D-1 cassette tapes and their associated recorders were designed to operate in broadcast studios and record in accordance with the International Radio Consultative Committee (CCIR) 607 digital video standards. The D-1 recorder resulted in the Society of Motion Picture and Television Engineers (SMPTE) standards 224 to 228 and is the first digital video recorder to be standardized for the broadcast industry. The D-1 cassette and associated media are currently marketed for broadcast use. The recorder was redesigned for data applications and is in the early stages of being evaluated. The digital data formats used are specified in MIL-STD-2179 and the American National Standards Institute (ANSI) X3.175-190 standard. In early 1990, the National Media Laboratory (NML) was asked to study the effects of time, temperature, and relative humidity on commercial D-1 cassettes. The environmental range to be studied was the one selected for the Advanced Tactical Air Reconnaissance System (ATARS) program. Several discussions between NML personnel, ATARS representatives, recorder contractors, and other interested parties were held to decide upon the experimental plan to be implemented. Review meetings were held periodically during the course of the experiment. The experiments were designed to determine the dimensional stability of the media and cassette since this is one of the major limiting factors of helical recorders when the media or recorders are subjected to non-broadcasting environments. Measurements were also made to characterize each sample of cassettes to give preliminary information on which purchase specifications could be developed. The actual tests performed on the cassettes and media before and after aging fall into the general categories listed.
International Nuclear Information System (INIS)
Khalid S Aljabri; Somoa A Bokhari; Murtadha J. Khan
2010-01-01
A prospective, nonblinded and nonrandomized controlled trial was conducted to test the hypothesis that vitamin D supplementation would improve glycemic control in patients with type 1 diabetes mellitus who have vitamin D deficiency. Patients and 0 Eighty patients with type 1 diabetes mellitus who had 25-hydroxyvitamin D levels less than 50 nmol/L were assigned to receive 4000 IU of vitamin D3. Calcium supplements were provided to ensure a total calcium intake of 1200 mg/d. Glycosylated hemoglobin and 25-hydroxyvitamin D levels were measured at baseline and at 12 weeks.There was a significant difference in mean (SD) glycosylated hemoglobin level (%) between the groups that achieved 25-hydroxyvitamin D levels of 51 nmol/L at 12 weeks (P=.02). There was a significant difference in glycosylated hemoglobin change from baseline between the groups that achieved 25-hydroxyvitamin D levels of 51 nmol/L at 12 weeks (P=.04). There was a significant difference in 25-hydroxyvitamin D level between the groups that achieved glycosylated hemoglobin levels of 9.9 at 12 weeks (P=.001). Patients were more likely to achieve lower glycosylated hemoglobin levels at 12 weeks if they had higher 25-hydroxyvitamin D levels at 12 weeks (r=-0.4, P=.001).There was an observed effect of vitamin D supplementation on glycemic control in vitamin D-replete, type 1 diabetes mellitus patients. Further studies are needed to determine if these findings are applicable (Author).
Temperature dependence of the helium induced broadening and shift of the Rb D1 and D2 lines
Miller, Wooddy S.; Rice, Christopher A.; Perram, Glen P.
2018-02-01
The rates for collisional broadening and shifting of the Rb D1 (52S1/2 - 52P1/2) and D2 (52S1/2 - 52P3/2) transition induced by 4He have been measured at elevated temperatures of 373-723 K. The shift coefficients exhibit an increase of 20% from 4.36 MHz/Torr to 5.35 MHz/Torr for the D1 line and an 80% increase from 0.42 MHz/Torr to 0.99 MHz/Torr for the D2 line over the observed temperature range. Broadening coefficients exhibit a 6% increase from 17.8 MHz/Torr to 18.9 MHz/Torr and 10% from 18.5 MHz/Torr to 20.5 MHz/Torr for the D1 and D2 lines, respectively. The experimental values agree well with prior reported values within the temperature overlap regions of T < 394 K. Comparison to prior predictions from the Anderson-Talman theory using spin orbit multi reference (SOCI) ab initio potentials are superior to quantum treatments involving Allard and Baranger coupling.
Nishino, Hitoshi; Rajpoot, Subhash
2018-03-01
We formulate an N = (2 , 0) system in D = 3 + 3 dimensions consisting of a Yang-Mills (YM)-multiplet (ˆ μ ˆ IA, λˆI), a self-dual non-Abelian tensor multiplet (ˆ μ ˆ ν ˆ IB, χˆI ,φˆI), and an extra vector multiplet (C ˆ μ ˆ IC, ρˆI). We next perform the dimensional reductions of this system into D = 2 + 2, and obtain N = (1 , 1) systems with a self-dual YM-multiplet (AIμ ,λI), a self-dual tensor multiplet (BIμν , χI , φI), and an extra vector multiplet (CIμ , ρI). In D = 2 + 2, we reach two distinct theories: 'Theory-I' and 'Theory-II'. The former has the self-dual field-strength Hμν(+)I of CIμ already presented in our recent paper, while the latter has anti-self-dual field strength Hμν(-)I. As an application, we show that Theory-II actually generates supersymmetric-KdV equations in D = 1 + 1. Our result leads to a new conclusion that the D = 3 + 3 theory with non-Abelian tensor multiplet can be a 'Grand Master Theory' for self-dual multiplet and self-dual YM-multiplet in D = 2 + 2, that in turn has been conjectured to be the 'Master Theory' for all supersymmetric integrable theories in D ≤ 3.
Data of evolutionary structure change: 1GCWC-2QU0D [Confc[Archive
Lifescience Database Archive (English)
Full Text Available pdbID> D 2QU0D ence>ARHHGNEFTPVence> D 2QU0D ence>FWGKV--KVDEV...1GCWC-2QU0D 1GCW 2QU0 C D AFTACEKQTIGKIAQVLAKSPEAYGAECLARLFVTHPGS... 1GCW C 1GCWC ence>YKDYS-----AAGAK...2 LYS CA 240 2QU0 D 2QU
Production, purification, sequencing and activity spectra of mutacins D-123.1 and F-59.1.
Nicolas, Guillaume G; LaPointe, Gisèle; Lavoie, Marc C
2011-04-10
The increase in bacterial resistance to antibiotics impels the development of new anti-bacterial substances. Mutacins (bacteriocins) are small antibacterial peptides produced by Streptococcus mutans showing activity against bacterial pathogens. The objective of the study was to produce and characterise additional mutacins in order to find new useful antibacterial substances. Mutacin F-59.1 was produced in liquid media by S. mutans 59.1 while production of mutacin D-123.1 by S. mutans 123.1 was obtained in semi-solid media. Mutacins were purified by hydrophobic chromatography. The amino acid sequences of the mutacins were obtained by Edman degradation and their molecular mass was determined by mass spectrometry. Mutacin F-59.1 consists of 25 amino acids, containing the YGNGV consensus sequence of pediocin-like bacteriocins with a molecular mass calculated at 2719 Da. Mutacin D-123.1 has an identical molecular mass (2364 Da) with the same first 9 amino acids as mutacin I. Mutacins D-123.1 and F-59.1 have wide activity spectra inhibiting human and food-borne pathogens. The lantibiotic mutacin D-123.1 possesses a broader activity spectrum than mutacin F-59.1 against the bacterial strains tested. Mutacin F-59.1 is the first pediocin-like bacteriocin identified and characterised that is produced by Streptococcus mutans. Mutacin D-123.1 appears to be identical to mutacin I previously identified in different strains of S. mutans.
Production, purification, sequencing and activity spectra of mutacins D-123.1 and F-59.1
Directory of Open Access Journals (Sweden)
LaPointe Gisèle
2011-04-01
Full Text Available Abstract Background The increase in bacterial resistance to antibiotics impels the development of new anti-bacterial substances. Mutacins (bacteriocins are small antibacterial peptides produced by Streptococcus mutans showing activity against bacterial pathogens. The objective of the study was to produce and characterise additional mutacins in order to find new useful antibacterial substances. Results Mutacin F-59.1 was produced in liquid media by S. mutans 59.1 while production of mutacin D-123.1 by S. mutans 123.1 was obtained in semi-solid media. Mutacins were purified by hydrophobic chromatography. The amino acid sequences of the mutacins were obtained by Edman degradation and their molecular mass was determined by mass spectrometry. Mutacin F-59.1 consists of 25 amino acids, containing the YGNGV consensus sequence of pediocin-like bacteriocins with a molecular mass calculated at 2719 Da. Mutacin D-123.1 has an identical molecular mass (2364 Da with the same first 9 amino acids as mutacin I. Mutacins D-123.1 and F-59.1 have wide activity spectra inhibiting human and food-borne pathogens. The lantibiotic mutacin D-123.1 possesses a broader activity spectrum than mutacin F-59.1 against the bacterial strains tested. Conclusion Mutacin F-59.1 is the first pediocin-like bacteriocin identified and characterised that is produced by Streptococcus mutans. Mutacin D-123.1 appears to be identical to mutacin I previously identified in different strains of S. mutans.