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Sample records for bipolar tissue sealing

  1. Effect of collagen and elastin content on the burst pressure of human blood vessel seals formed with a bipolar tissue sealing system.

    Science.gov (United States)

    Latimer, Cassandra A; Nelson, Meghan; Moore, Camille M; Martin, Kimberly E

    2014-01-01

    Bipolar devices are routinely used to seal blood vessels instead of sutures and clips. Recent work examining the impact of vascular proteins on bipolar seal performance found that collagen and elastin (CE) content within porcine arteries was a significant predictor of a vessel's burst pressure (VBPr). This study examined seal performance across a range of human blood vessels to investigate whether a similar relationship existed. In addition, we compared VBPr and CE content between porcine and human blood vessels. Our primary hypothesis is that higher collagen-to-elastin ratio will predict higher VBPr in human vasculature. In six cadavers, 185 blood vessels from nine anatomic locations were sealed using a bipolar electrosurgical system. A linear mixed model framework was used to evaluate the impact of vessel diameter and CE content on VBPr. The effect of CE ratio on VBPr is modified by vessel size, with CE ratio having larger influence on VBPr in smaller diameter vessels. Seal burst pressure of vessels 2-5 mm in diameter was significantly associated with their CE content. Comparison of average VBPr between species revealed porcine carotid and iliac arteries (440-670 mmHg) to be the best vessel types for predicting the seal strength of most human blood vessels (420-570 mmHg) examined. CE content significantly modified the seal strength of small to medium sized blood vessels but had limited impact on vessels >5 mm. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Clinical effects of the use of a bipolar vessel sealing device for soft palate resection and tonsillectomy in dogs, with histological assessment of resected tonsillar tissue.

    Science.gov (United States)

    Cook, D A; Moses, P A; Mackie, J T

    2015-12-01

    To investigate whether soft palate resection and tonsillectomy with a bipolar vessel sealing device (BVSD) improves clinical respiratory score. To document histopathological changes to tonsillar tissue following removal with a BVSD. Case series of 22 dogs with clinical signs of upper respiratory obstruction related to brachycephalic airway syndrome. Soft palate and tonsils were removed using a BVSD. Alarplasty and saccullectomy were also performed if indicated. A clinical respiratory score was assigned preoperatively, 24-h postoperatively and 5 weeks postoperatively. Excised tonsillar samples were measured and then assessed histologically for depth of tissue damage deemed to be caused by the device. Depth of tissue damage was compared between two power settings of the device. Soft palate resection and tonsillectomy with a BVSD lead to a significant improvement in respiratory scores following surgery. Depth of tissue damage was significantly less for power setting 1 compared with power setting 2. Using power setting 1, median calculated depth of tonsillar tissue damage was 3.4 mm (range 1.2-8.0). One dog experienced major complications. Soft palate resection and tonsillectomy with a BVSD led to significant improvement in clinical respiratory score. © 2015 Australian Veterinary Association.

  3. Validation of a Laparoscopic Ferromagnetic Technology-based Vessel Sealing Device and Comparative Study to Ultrasonic and Bipolar Laparoscopic Devices.

    Science.gov (United States)

    Chen, Jennwood; Jensen, Curtis R; Manwaring, Preston K; Glasgow, Robert E

    2017-04-01

    Ferromagnetic heating is a new electrosurgery energy modality that has proven effective in hemostatic tissue dissection as well as sealing and dividing blood vessels and vascularized tissue. The purpose of this study was to evaluate a ferromagnetic-based laparoscopic vessel sealing device with respect to sealing and dividing vessels and vascularized tissue and to compare performance against current vessel sealing technologies. A laparoscopic vessel sealing device, Laparoscopic FMsealer (LFM), was studied for efficacy in sealing and dividing blood vessels and comparative studies against predicate ultrasonic, Harmonic Ace+(US), and/or bipolar, LigaSure 5 mm Blunt Tip and/or Maryland (BP), devices in vivo using a swine model and in vitro for comparison of seal burst pressure and reliability. Mann-Whitney and Student t test were used for statistical comparisons. In division of 10 cm swine small bowel mesentery in vivo, the laparoscopic FMsealer [12.4±1.8 sec (mean±SD)], was faster compared with US (26.8±2.5 s) and BP (30.0±2.7 s), Pburst strength and success of sealing 2 to 4 mm arteries were as follows (mean±SD mm Hg, % success burst strength >240 mm Hg): LFM (1079±494 mm Hg, 98.1% success) versus BP (1012±463, 99.0%), P=NS. For 5 to 7 mm arteries: LFM (1098±502 mm Hg, 95.3% success) versus BP (715±440, 91.8%), Pburst strength and P=NS in % success. Five 60 kg female swine underwent 21-day survival studies following ligation of vessels ranging from 1 to 7 mm in diameter (n=186 total vessels). Primary seal was successful in 97%, 99% including salvage seals. There was no evidence of postoperative bleeding at sealed vessels at 21-day necropsy. The Laparoscopic FMsealer is an effective tool for sealing and dividing blood vessels and vascularized tissue and compares favorably to current technologies in clinically relevant end points.

  4. Use of a bipolar vessel-sealing device in resection of canine insulinoma

    NARCIS (Netherlands)

    Wouters, E.G.H.; Buishand, F.O.; Kik, M.J.L.; Kirpensteijn, J.

    2011-01-01

    OBJECTIVES: To describe partial pancreatectomy using a bipolar vessel-sealing device (BVSD) and compare this novel technique to the conventional suture-fracture (SF) method for canine insulinoma. METHODS: Pre-, intra- and postoperative data of eight dogs with insulinoma, which underwent resection

  5. Electrosurgical bipolar vessel sealing versus conventional clamping and suturing for vaginal hysterectomy: a randomised controlled trial

    NARCIS (Netherlands)

    Lakeman, M. M. E.; The, S.; Schellart, R. P.; Dietz, V.; ter Haar, J. F.; Thurkow, A.; Scholten, P. C.; Dijkgraaf, M. G. W.; Roovers, J. P. W. R.

    2012-01-01

    Please cite this paper as: Lakeman M, The S, Schellart R, Dietz V, ter Haar J, Thurkow A, Scholten P, Dijkgraaf M, Roovers J. Electrosurgical bipolar vessel sealing versus conventional clamping and suturing for vaginal hysterectomy: a randomised controlled trial. BJOG 2012;119:14731482. Objective To

  6. A new bipolar feedback-controlled sealing system for closure of the cystic duct and artery.

    Science.gov (United States)

    Shamiyeh, A; Schrenk, P; Tulipan, L; Vattay, P; Bogner, S; Wayand, W

    2002-05-01

    Bile leaks are serious complications after laparoscopic cholecystectomy. The aim of this study was to evaluate the feasibility of closure of the cystic duct with a new feedback-controlled bipolar sealing system (LigaSure). Ten domestic pigs underwent open cholecystectomy with the cystic duct and artery dissected and sealed with the new bipolar sealing system (LigaSure). Four and 8 days postoperatively, 5 pigs each were sacrificed and the closure of the cystic duct was evaluated. The cystic stump and the common bile duct were excised for histological examination. None of the pigs had a bile leak or a biliary peritonitis. There were no signs of postoperative bleeding or inflammation in Calot's triangle. Histology showed total necrosis of the cystic duct in the first two pigs due to too much energy used. The remaining specimens showed a regularly scaling zone without necrosis in 7 cases, and in one case a partial necrosis in the mucosa only was found. Cystic artery and cystic duct closure with the new device may be an alternative to the clip. Further trials should evaluate the feasibility and safety of the new device in the clinical setting.

  7. Imaging the spectral reflectance properties of bipolar radiofrequency-fused bowel tissue

    Science.gov (United States)

    Clancy, Neil T.; Arya, Shobhit; Stoyanov, Danail; Du, Xiaofei; Hanna, George B.; Elson, Daniel S.

    2015-07-01

    Delivery of radiofrequency (RF) electrical energy is used during surgery to heat and seal tissue, such as vessels, allowing resection without blood loss. Recent work has suggested that this approach may be extended to allow surgical attachment of larger tissue segments for applications such as bowel anastomosis. In a large series of porcine surgical procedures bipolar RF energy was used to resect and re-seal the small bowel in vivo with a commercial tissue fusion device (Ligasure; Covidien PLC, USA). The tissue was then imaged with a multispectral imaging laparoscope to obtain a spectral datacube comprising both fused and healthy tissue. Maps of blood volume, oxygen saturation and scattering power were derived from the measured reflectance spectra using an optimised light-tissue interaction model. A 60% increase in reflectance of visible light (460-700 nm) was observed after fusion, with the tissue taking on a white appearance. Despite this the distinctive shape of the haemoglobin absorption spectrum was still noticeable in the 460-600 nm wavelength range. Scattering power increased in the fused region in comparison to normal serosa, while blood volume and oxygen saturation decreased. Observed fusion-induced changes in the reflectance spectrum are consistent with the biophysical changes induced through tissue denaturation and increased collagen cross-linking. The multispectral imager allows mapping of the spatial extent of these changes and classification of the zone of damaged tissue. Further analysis of the spectral data in parallel with histopathological examination of excised specimens will allow correlation of the optical property changes with microscopic alterations in tissue structure.

  8. In silico evaluation of geometry variations with respect to the thermal spread during coagulation of egg white using bipolar vessel sealing instruments.

    Science.gov (United States)

    Wagenpfeil, Jay; Schöllig, Christina; Mayer, Volker; Feuer, Ronny; Nold, Bernhard; Neugebauer, Alexander; Ederer, Michael; Rothmund, Ralf; Krämer, Bernhard; Brucker, Sara; Enderle, Markus; Sawodny, Oliver; Rex, Julia

    2016-11-02

    Bipolar vessel sealing is an efficient electrosurgical procedure for the occlusion of blood vessels particularly during minimally invasive surgery. Reliable knowledge of the thermal spread is crucial for a safe application of bipolar vessel sealing instruments when operating close to thermo-sensitive structures, such as nerves. The evolution of the thermal spread over time and space depends on a variety of parameters, such as the biological tissue, the energy applied to the tissue, and the geometry of the vessel sealing instrument. Mathematical modeling has proven useful for the prediction of the thermal spread. It is, thus, a promising tool for the systematic analysis of the influence of geometrical changes on the thermal spread. We present an experimentally validated in silico study to evaluate the impact of geometry variations on the progression of chicken egg white coagulation and the final shape of coagulated egg white as an approximation of the temporal and spatial evolution of the thermal spread during bipolar vessel sealing. Egg white has similar thermal and electrical properties to human tissue, with the advantage being that the spatial and temporal evolution of the thermal spread can be visually gauged. The simulations were performed using a mathematical model based on the finite element analysis of chicken egg white. The progression of egg white coagulation was predicted for two different peak voltages and various electrode geometries. Starting with two planar electrodes, one electrode was gradually changed to adopt a wedge shape. These changes to the geometry showed a distinct influence on the progression of egg white coagulation in the simulations. The predictions were successfully validated using an experimental setup with two different electrodes representing the extreme geometries. The predicted spatial temperature distributions were experimentally validated for two geometries. Our simulation study shows that the geometry has a pronounced influence

  9. LAPAROSCOPICALLY ASSISTED ANORECTOPLASTY AND THE USE OF THE BIPOLAR DEVICE TO SEAL THE RECTAL URINARY FISTULA.

    Science.gov (United States)

    Dutra, Robson Azevedo; Boscollo, Adriana Cartafina Perez

    2016-01-01

    The anorectal anomalies consist in a complex group of birth defects. Laparoscopic-assisted anorectoplasty improved visualization of the rectal fistula and the ability to place the pull-through segment within the elevator muscle complex with minimal dissection. There is no consensus on how the fistula should be managed. To evaluate the laparoscopic-assisted anorectoplasty and the treatment of the rectal urinary fistula by a bipolar sealing device. It was performed according to the original description by Georgeson1. Was used 10 mm infraumbilical access portal for 30º optics. The pneumoperitoneum was established with pressure 8-10 cm H2O. Two additional trocars of 5 mm were placed on the right and left of the umbilicus. The dissection started on peritoneal reflection using Ligasure(r). With the reduction in the diameter of the distal rectum was identified the fistula to the urinary tract. The location of the new anus was defined by the location of the external anal sphincter muscle complex, using electro muscle stimulator externally. Finally, it was made an anastomosis between the rectum and the new location of the anus. A Foley urethral probe was left for seven days. Seven males were operated, six with rectoprostatic and one with rectovesical fistula. The follow-up period ranged from one to four years. The last two patients operated underwent bipolar sealing of the fistula between the rectum and urethra without sutures or surgical ligation. No evidence of urethral leaks was identified. There are benefits of the laparoscopic-assisted anorectoplasty for the treatment of anorectal anomaly. The use of a bipolar energy source that seals the rectal urinary fistula has provided a significant decrease in the operating time and made the procedure be more elegant. As anomalias anorretais consistem de um grupo complexo de defeitos congênitos. A anorretoplastia laparoscópica permite melhor visualização da fístula retourinária e propicia o posicionamento do reto abaixado

  10. Electrothermal bipolar vessel sealing device vs. ultrasonic coagulating shears in laparoscopic colectomies: a comparative study.

    Science.gov (United States)

    Campagnacci, Roberto; de Sanctis, Angelo; Baldarelli, Maddalena; Rimini, Massimiliano; Lezoche, Giovanni; Guerrieri, Mario

    2007-09-01

    Many devices are available for vascular control during laparoscopic colorectal procedures. Ultrasonic coagulating shears (UCS), vascular staplers, titanium or plastic clips, and electrothermal bipolar vessel sealing (EBVS) are currently used according to the surgeon's preference. This study aimed to compare EBVS Ligasure with UCS. We report the outcome of 200 consecutive unselected patients who underwent laparoscopic colorectal resections of which 100 were performed with EBVS Ligasure (from September 2004 to December 2005, group 1) and 100 with UCS harmonic scalpel (from December 2002 to June 2004, group 2). Only the following three types of operation were performed: right colectomy (RC), left colectomy (LC), and low anterior resections (LAR). Emergency procedures have been excluded. The same attending surgical teams performed or supervised all procedures. Operating time, blood loss, complications, and postoperative hospital stay were investigated. Age, gender, previous surgical abdominal procedures, and ASA risk were similar between the two groups, as well as was the percentage of malignant cases (74% vs. 71%, respectively). There were 32 vs. 37 RC, 50 vs. 47 LC, and 18 vs. 16 LAR in groups 1 and 2, respectively. There was no mortality in either group. A conversion to open surgery and two major complications occurred in group 2. There were no statistically significant differences in mean operating time (111 vs. 133, 140 vs. 176, and 153 vs. 201 min) and in the mean postoperative hospital stay (5.2 vs. 6.1, 6.5 vs. 7.1, and 6.8 vs 7.3 days) for RC, LC, and LAR between group 1 and 2, respectively. We do report interesting data about statistically significant differences in the blood loss: 115 vs. 370, 150 vs. 455, and 185 vs. 495 ml for RC (p group 1 and group 2, respectively. In our laparoscopic colorectal experience, EBVS Ligasure has proven safe and effective in vessel sealing. Patients in whom this device was used had less blood loss and slight advantages in

  11. Modeling Unipolar and Bipolar Stimulation of Cardiac Tissue

    Science.gov (United States)

    Galappaththige, Suran Kokila

    Out of all non-communicable diseases, heart diseases have become the leading cause of death and disease burden worldwide. Heart diseases describe a variety of circumstances that affect your heart. One common condition is the heart rhythm problem often called an arrhythmia. The rhythmic beating of the human heart can be altered due to various reasons. This inconsistency in beating can lead to a lethal form of arrhythmia that we call ventricular fibrillation. We treat fibrillation by applying an electrical shock to the heart using a unipolar electrode or bipolar electrodes. To build better pace makers and defibrillators, we must understand how the heart responds to an electrical shock. One way to study cardiac arrhythmias is using a mathematical model. The computational biology of the heart is one of the most important recent applications of mathematical modeling in biology. By using mathematical models, we can understand the mechanisms responsible of the heart's electrical behavior. We investigate if the time-independent, inwardly rectifying potassium current through the cell membrane inhibits the hyperpolarization after a stimulus electrical pulse is applied to the resting heart tissue. The inhibition of hyperpolarization is due to long duration stimulus pulses, but not short duration pulses. We also investigate the minimum conditions required for the dip in strength-interval curves using a simple but not so simple parsimonious ionic current model coupled with the bidomain model. Unipolar anodal stimulations still results in the dip in the strength-interval curves and this explains the minimum conditions for this phenomenon to occur. Bipolar stimulation of cardiac tissue using the parsimonious ionic current model revels that the strength-interval curves are sensitive to the separation between electrodes and the electrode orientation relative to the fiber direction. One of the ionic currents in the parsimonious ionic current model mimics the time

  12. Fabrication of gas impervious edge seal for a bipolar gas distribution assembly for use in a fuel cell

    Science.gov (United States)

    Kaufman, Arthur; Werth, John

    1986-01-01

    A bipolar gas reactant distribution assembly for use in a fuel cell is disclosed, the assembly having a solid edge seal to prevent leakage of gaseous reactants wherein a pair of porous plates are provided with peripheral slits generally parallel to, and spaced apart from two edges of the plate, the slit being filled with a solid, fusible, gas impervious edge sealing compound. The plates are assembled with opposite faces adjacent one another with a layer of a fusible sealant material therebetween the slits in the individual plates being approximately perpendicular to one another. The plates are bonded to each other by the simultaneous application of heat and pressure to cause a redistribution of the sealant into the pores of the adjacent plate surfaces and to cause the edge sealing compound to flow and impregnate the region of the plates adjacent the slits and comingle with the sealant layer material to form a continuous layer of sealant along the edges of the assembled plates.

  13. Gas emission during laparoscopic colorectal surgery using a bipolar vessel sealing device: A pilot study on four patients

    Directory of Open Access Journals (Sweden)

    Gianella Michele

    2008-09-01

    Full Text Available Abstract Background Dissection during laparoscopic surgery produces smoke containing potentially toxic substances. The aim of the present study was to analyze smoke samples produced during laparoscopic colon surgery using a bipolar vessel sealing device (LigaSure™. Methods Four consecutive patients undergoing left-sided colectomy were enrolled in this pilot study. Smoke was produced by the use of LigaSure™. Samples (5,5l were evacuated from the pneumoperitoneum in a closed system into a reservoir. Analysis was performed with CO2-laser-based photoacoustic spectroscopy and confirmed by a Fourier-transform infrared spectrum. The detected spectra were compared to the available spectra of known toxins. Results Samples from four laparoscopic sigmoid resections were analyzed. No relevant differences were noted regarding patient and operation characteristics. The gas samples were stable over time proven by congruent control measurements as late as 24 h after sampling. The absorption spectra differed considerably between the patients. One broad absorption line at 100 ppm indicating H2O and several unknown molecules were detected. With a sensitivity of alpha min ca 10-5 cm-1 no known toxic substances like phenol or indole were identified. Conclusion The use of a vessel sealing device during laparoscopic surgery does not produce known toxic substances in relevant quantity. Further studies are needed to identify unknown molecules and to analyze gas emission under various conditions.

  14. Use of an electrothermal bipolar sealing device in ligation of major mesenteric vessels during laparoscopic colorectal resection.

    LENUS (Irish Health Repository)

    Martin, S T

    2012-02-01

    BACKGROUND: A variety of approaches are available for division of major vascular structures during laparoscopic colorectal resection. Ultrasonic coagulating shears (UCS), vascular staplers, plastic or titanium clips and electrothermal bipolar vessel sealing (EBVS) are currently available. We report our experience with an EBVS device, LigaSure (Covidien AG), used in division of the ileocolic, middle colic and inferior mesenteric arteries during laparoscopic colorectal resection. METHODS: We report the immediate outcome of 802 consecutive unselected patients who underwent elective laparoscopic colorectal cancer resection performed with use of the LigaSure (5 and 10 mm) at our institution over a 5-year period. Operative procedures included right hemicolectomy (n = 180), left hemicolectomy (n = 96), sigmoid colectomy (n = 347) and anterior resection (n = 179). Data were collected from a prospectively maintained cancer database and operative records. The procedures were performed primarily by three consultant surgeons with an interest in laparoscopic colorectal resection. RESULTS: Of 802 cases in which the LigaSure device was employed to divide major vascular structures, immediate effective vessel sealing was achieved in 99.8% (n = 800). Two patients experienced related adverse events both following division of the inferior mesenteric artery with a 5 mm LigaSure. Both patients had immediate uncontrolled haemorrhage that required laparotomy. CONCLUSIONS: Use of the LigaSure device to seal and divide the major mesenteric vessels during laparoscopic colorectal resection is very effective, with a high success rate of 99.8%. Caution should be exercised in elderly atherosclerotic patients, particularly when using the 5-mm LigaSure device.

  15. Seals

    International Nuclear Information System (INIS)

    Welsher, R.A.G.

    1982-01-01

    An aperture through a biological shield is sealed by a flexible sheath having a beading at one end located on an annular member slidable in the aperture such that the beading bears in sealing engagement against the sides of the aperture. The annular member is retained by a retractable latch and can be rejected by pushing it out of the aperture using a replacement annular member with a replacement sheath thereon to butt against the annular member to be rejected. The replacement annular member may be mounted on a tubular device having an outer co-axial member for operating the latch when the replacement annular member butts against the annular member to be rejected. Applications include effecting a seal between a remote handling equipment and a wall through which the equipment extends. (author)

  16. Cordless ultrasonic dissector versus advanced bipolar vessel sealing device for laparoscopic ovariectomy in dogs

    NARCIS (Netherlands)

    Spillebeen, Anneleen L; Janssens, Sara S D S; Thomas, Rachel E; Kirpensteijn, Jolle; van Nimwegen, Sebastiaan A

    OBJECTIVE: To compare Sonicision cordless ultrasonic dissector (SCUD) to LigaSure vessel sealing device (LVSD) for laparoscopic ovariectomy (Lap OVE) in dogs. STUDY DESIGN: Randomized, paired prospective clinical trial. ANIMALS: Client-owned dogs (n = 22) presented for elective Lap OVE. METHODS:

  17. Bipolar fracture dislocation of clavicle: A report of osteosynthesis and early soft tissue reconstruction

    Directory of Open Access Journals (Sweden)

    Renaldi Prasetia

    Full Text Available Introduction: Bipolar dislocation of the clavicle, also called bifocal or pan-articular dislocation or floating clavicle, is an uncommon traumatic injury. The injury of this case is also concomitant with distal third clavicle and coracoid fracture. This article aimed to report the experience of performing osteosynthesis and early soft tissue reconstruction on these injuries. Case report: We reported a case of bipolar clavicle fracture-dislocation in concomitant with coracoid fracture in a man, aged 32 years old, successfully treated 24 days after accident by fixation of both fractures and early simultaneous reconstruction of sternoclavicular- acromioclavicular-coracoclavicular joints. Discussion: These injuries are rare and capable of causing many complications if they are treated improperly. It is compulsory to carefully assess any fractured clavicle along its whole length, both clinically and radiologically. Various options, from non-operative to operative, have been reported to manage such of these cases. Early bony fixation and soft tissue reconstruction can correct the alignment of clavicle and recover the function of sterno-clavicular and acromio-clavicular- joints promptly. Conclusion: Fracture osteosynthesis and early soft tissue reconstruction can be regarded as an option treatment for bipolar fracture-dislocation of the clavicle to facilitate prompt treatment and early rehabilitation. Keywords: Bipolar dislocation, Floating clavicle, Early reconstruction, Soft tissue reconstruction

  18. Enantioselective gas chromatographic separation of methylsulfonyl PCBs in seal blubber, pelican muscle and human adipose tissues

    Energy Technology Data Exchange (ETDEWEB)

    Karasek, L.; Rosmus, J. [Veterinary Institute Prague (Czech Republic). Dept. of Chemistry; Hajslova, J. [Institute of Chemical Technology (Czech Republic). Dept. of Food Chemistry and Analysis; Huehnerfuss, H. [Hamburg Univ. (Germany). Inst. fuer Organische Chemie

    2004-09-15

    Methyl sulfone derivatives are known to represent primary metabolic products of PCBs (MeSO2- CB) and DDE (MeSO2-DDE). These metabolites are formed via mercapturic acid pathway and belong to persistent, lipophilic compounds which accumulate in the adipose, lung, liver and kidney tissues of mammals exposed to PCBs. In 1976 Jenssen and Jansson reported the identification of PCB methyl sulfones as metabolites of PCBs in Baltic grey seal blubber. Methyl sulfones are moderately polar compounds that are only slightly less hydrophobic than the parent PCBs, and their partition coefficients fulfill the requirements for bioaccumulation. The highest concentrations have been found in kidney and lung tissues of seals, otters, beluga whales, polar bears, fishes and in human tissues. In the present investigation two samples of seal blubber, two pelican muscles and eleven human adipose tissue samples were analysed with regard to their concentrations of PCB parent compounds as well as to the respective chiral methylsulfonyl metabolites.

  19. Bipolar fracture dislocation of clavicle: A report of osteosynthesis and early soft tissue reconstruction.

    Science.gov (United States)

    Prasetia, Renaldi; Rasyid, Hermawan Nagar

    2017-01-01

    Bipolar dislocation of the clavicle, also called bifocal or pan-articular dislocation or floating clavicle, is an uncommon traumatic injury. The injury of this case is also concomitant with distal third clavicle and coracoid fracture. This article aimed to report the experience of performing osteosynthesis and early soft tissue reconstruction on these injuries. We reported a case of bipolar clavicle fracture-dislocation in concomitant with coracoid fracture in a man, aged 32 years old, successfully treated 24days after accident by fixation of both fractures and early simultaneous reconstruction of sternoclavicular- acromioclavicular-coracoclavicular joints. These injuries are rare and capable of causing many complications if they are treated improperly. It is compulsory to carefully assess any fractured clavicle along its whole length, both clinically and radiologically. Various options, from non-operative to operative, have been reported to manage such of these cases. Early bony fixation and soft tissue reconstruction can correct the alignment of clavicle and recover the function of sterno-clavicular and acromio-clavicular- joints promptly. Fracture osteosynthesis and early soft tissue reconstruction can be regarded as an option treatment for bipolar fracture-dislocation of the clavicle to facilitate prompt treatment and early rehabilitation. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  20. Tissue reaction to sealing materials: different view at biocompatibility

    Directory of Open Access Journals (Sweden)

    Ghanaati S

    2010-11-01

    Full Text Available Abstract The biodegradability of root canal sealers in areas other than the root canal system is crucial to the overall success rate of endodontic treatment. The aim of the present study was to investigate, the cell and tissue reaction to GuttaFlow and AHPlus, both in vitro and in vivo. For the in vitro experiments the materials were incubated with Human Periodontal Ligament Fibroblasts and cell proliferation and cytotoxicity analyses were performed. Additional fluorescence-microscope stainings were carried out in order to visualize cell growth and morphology. For assessment of the tissue reaction to the materials a subcutaneous implantation model in Wistar rats was employed and the inflammatory response to the materials was visualized by means of general and specific histology after 6 weeks. Human gingival fibroblasts proliferation seemed to be dependent upon dental material and cultivation time. After an incubation period of 96 hrs AHPlus proved to be significantly (p

  1. A brief review of techniques used to seal corneal perforation using cyanoacrylate tissue adhesive.

    Science.gov (United States)

    Rana, M; Savant, V

    2013-08-01

    There are many modalities in use to treat corneal perforations. One of most commonly used modality these days is the use of tissue adhesive. Cyanoacrylate adhesive is the commonest type of tissue adhesive used. To describe various techniques used for corneal glueing with cyanoacrylate tissue adhesive and to suggest a new technique for the same. We describe here a brief review of different techniques of tissue glue application and suggest a modified new technique to apply tissue glue over the area of corneal perforation to achieve a nice smooth and stable seal. The importance of good glueing technique is to provide a stable and a closed wound so that it can help the epithelium grow and close the perforation. We present three different techniques of corneal glueing to seal corneal perforations. These different techniques of glueing can be used to seal corneal perforations. It is up to the reader to try all three techniques and then follow whichever gives the best and smooth results. Copyright © 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

  2. Closure of the cystic duct during laparoscopic cholecystectomy with a new feedback-controlled bipolar sealing system in case of biliary obstruction--an experimental study in pigs.

    Science.gov (United States)

    Shamiyeh, A; Vattay, P; Tulipan, L; Schrenk, P; Bogner, S; Danis, J; Wayand, W

    2004-01-01

    The excellent results of new devices like the new bipolar feedback-controlled sealing system (LigaSure) for closure of blood vessels encouraged surgeons to use these instruments for other structures like bile ducts. The aim of this study was to evaluate the feasibility of closure of cystic duct in case of biliary obstruction. Ten domestic pigs underwent laparoscopic cholecystectomy sealing the cystic duct with LigaSure. The common bile duct was closed with an endoclip to create a biliary hypertension. On the 12th postoperative day blood samples were taken for liver enzymes. At autopsy on day 15 the pigs were investigated for bile leaks or biliary peritonitis. The cystic duct was resected for histological examination. Seven pigs survived, one pig died during introduction of anesthesia, one on the 1st and one on the 2nd postoperative day without any findings at the autopsy. One pig out of 7 had a bile leak; the other 6 were without any sign of leakage. Histologically 3 pigs had a regular coagulation zone at the cystic duct, 3 had a total necrosis, one a partial necrosis of the mucosa only. Though there was only one insufficiency, the feedback-controlled bipolar vessel sealer cannot be recommended for biliary surgery with regard to the high rate of necrosis stated in our experiment.

  3. No effect of bipolar interferential electrotherapy and pulsed ultrasound for soft tissue shoulder disorders : a randomised controlled trial

    NARCIS (Netherlands)

    Van Der Heijden, G J; Leffers, P; Wolters, P J; Verheijden, J J; van Mameren, H; Houben, J P; Bouter, L M; Knipschild, P G

    OBJECTIVE: To assess the efficacy of bipolar interferential electrotherapy (ET) and pulsed ultrasound (US) as adjuvants to exercise therapy for soft tissue shoulder disorders (SD). METHODS: Randomised placebo controlled trial with a two by two factorial design plus an additional control group in 17

  4. Histological changes in connective tissue of rat tails after bipolar radiofrequency treatment.

    Science.gov (United States)

    Beltrán-Frutos, E; Bernal-Mañas, C M; Navarro, S; Zuasti, A; Ferrer, C; Canteras, M; Seco-Rovira, V; García-Collado, A J; Pastor, L M

    2012-09-01

    Radiofrequency (RF) has been included in the techniques used in aesthetic surgery/medicine. To date, no studies have performed a histological assessment of changes in the tissue after application of bipolar radiofrequency (BRF) with low energy and frequency. The aim of this study was to examine changes that are produced in connective tissue, principally in the fibroblasts, following BRF treatment. Four groups of rats received a different number of RF sessions (1, 2, 3 and 5). The following parameters were determined: the number of fibroblasts/unit area (FA), the proliferation index (PI), the Heat shock Protein 47 index (HSPI) and the percentage of connective tissue (PC). For statistical analysis, two subgroups (A and B) were made for the variables FA, PI and PC, and another two subgroups (C and D) for the variable HSPI. Significant differences for FA, PI and PC were observed between subgroups A and B, FA and PI having higher values in A, while PC had higher values in B. The HSPI in subgroup C showed significantly higher values than in D. Low energy and frequency BRF led to an increase in the number, proliferation and biosynthetic activity of fibroblasts. The resulting stress suffered by fibroblasts as a result of heat may be associated with the phenomenon of hormesis.

  5. Mercury concentrations in seabird tissues from Machias Seal Island, New Brunswick, Canada

    Energy Technology Data Exchange (ETDEWEB)

    Bond, Alexander L., E-mail: abond@mun.ca [Atlantic Cooperative Wildlife Ecology Research Network, University of New Brunswick, PO Box 4400, Fredericton, New Brunswick, E3B 5A3 (Canada); Department of Biology, University of New Brunswick, PO Box 4400, Fredericton, New Brunswick, E3B 5A3 (Canada); Diamond, Antony W. [Atlantic Cooperative Wildlife Ecology Research Network, University of New Brunswick, PO Box 4400, Fredericton, New Brunswick, E3B 5A3 (Canada); Department of Biology, University of New Brunswick, PO Box 4400, Fredericton, New Brunswick, E3B 5A3 (Canada)

    2009-07-01

    Mercury is a pervasive environmental contaminant, the anthropogenic portion of which is increasing globally, and in northeastern North America in particular. Seabirds frequently are used as indicators of the marine environment, including mercury contamination. We analysed paired samples for total mercury (Hg) concentrations in feathers and blood from adult and chick, albumen, and lipid-free yolk of seven seabirds breeding on Machias Seal Island, New Brunswick, Canada - Arctic Tern (Sterna paradisaea), Atlantic Puffin (Fratercula arctica), Common Eider (Somateria mollissima), Common Murre (Uria aalge), Common Tern (Sterna hirundo), Leach's Storm-petrel (Oceanodroma leucorhoa), and Razorbill (Alca torda). We also used stable-isotope ratios of carbon ({delta}{sup 13}C), and nitrogen ({delta}{sup 15}N) to evaluate the relationship between carbon source and trophic position and mercury. We found high Hg concentrations across tissue types in Leach's Storm-petrels, and Razorbills, with lower concentrations in other species, the lowest being in Common Eiders. Storm-petrels prey on mesopelagic fish that accumulate mercury, and Razorbills feed on larger, older fish that bioaccumulate heavy metals. Biomagnification of Hg, or the increase in Hg concentration with trophic position as measured by {delta}{sup 15}N, was significant and greater in albumen than other tissues, whereas in other tissues, {delta}{sup 15}N explained little of the overall variation in Hg concentration. Hg concentrations in egg components are higher on Machias Seal Island than other sites globally and in the Gulf of Maine region, but only for some species. Further detailed investigations are required to determine the cause of this trend.

  6. Use of an electrothermal, feedback-controlled, bipolar sealing device for resection of the elongated portion of the soft palate in dogs with obstructive upper airway disease.

    Science.gov (United States)

    Brdecka, David J; Rawlings, Clarence A; Perry, Amanda C; Anderson, Jonathon R

    2008-10-15

    To evaluate efficacy and safety of using an electrothermal, feedback-controlled, bipolar sealing device (BSD) for resection of the elongated portion of the soft palate in brachycephalic dogs with upper airway obstruction. Uncontrolled clinical trial. 24 brachycephalic dogs with airway obstruction and elongated soft palate. In all dogs, the excess portion of the soft palate was resected with a BSD. A score for severity of clinical signs of respiratory tract obstruction was assigned before surgery, during the first 24 hours after surgery, and at the time of final follow-up 12 to 23 months after surgery. Potential scores ranged from 0 (no clinical signs even with moderate to vigorous activity) to 4 (agonal breathing or severe cyanosis). None of the dogs died or developed life-threatening complications after surgery. Clinical scores after surgery (mean +/- SD, 0.3 +/- 0.6) and at the time of final follow-up (0.9 + 0.5) were significantly lower than preoperative scores (2.6 +/- 0.8). Results indicated that a BSD can be safely used for resection of the elongated portion of the soft palate in brachycephalic dogs with upper airway obstruction.

  7. Histology of selected tissues of the leopard seal and implications for functional adaptations to an aquatic lifestyle.

    Science.gov (United States)

    Gray, Rachael; Canfield, Paul; Rogers, Tracey

    2006-08-01

    The microscopic anatomy of the cardio-respiratory system, digestive system, kidney, lymphatic system and integument was investigated in the leopard seal, Hydrurga leptonyx, by examining histological sections of tissues collected from leopard seals in Antarctica and New South Wales, Australia. The majority of the tissues had similar histological features to those described in terrestrial mammals and other pinniped species, particularly phocid seals. Differences noted included readily identifiable Purkinje cells within the endocardium, muscular rather than cartilaginous reinforcement of the smaller airways, a single capillary layer within the alveolar septa, limited and variable keratinization of the oesophageal epithelium, few lymphoid follicles within the lamina propria of the gastrointestinal tract, and an absence of a sporta perimedullaris musculosa described in the kidney of cetaceans and some pinniped species. Adaptations of the lung, spleen and integument, similar to those described in other pinnipeds, including reinforcement of the pulmonary terminal airways, prominent pulmonary interlobular septa, ample smooth muscle in the capsule and trabeculae of the spleen, increased thickness of the epidermis, well-developed dermal sebaceous glands, and a thick blubber layer, appear to confer upon the leopard seal advantages related to its aquatic lifestyle.

  8. Decreased hippocampal 5-HT2A receptors in post mortem tissue from schizophrenic but not bipolar subjects

    International Nuclear Information System (INIS)

    Scarr, E.; Pavey, G.; Bradbury, R.; Copolov, D.L.; Dean, B.

    2001-01-01

    Full text: The hippocampus is important in cognition and sensory gating,both of which are thought to be impaired in schizophrenia. Since 5HT has also been implicated in cognition we investigated the hippocampal serotonergic system in subjects with either schizophrenia or bipolar mood disorder. Using autoradiography,we found significant (p 3 H] ketanserin binding in the CA3 (Mean ±SEM:29.6 ± 4.0 vs.46.6 ± 4.2 fmol/mgETE), the stratum radiatum (27.3 ± 2.7 vs.38.7 ± 3.9 fmol/mgETE) and pyramidal cell layer (35.6 ± 3.4 vs.51.4 ± 2.7 fmol/ mgETE) of CA1 as well as the outer (8.3 ± 1.5 vs.12.2 ± 1.4 fmol/mgETE) and pyramidal cell layer (16.4 ± 2.5 vs.32.1 ± 3.2 fmol/mgETE) of the subiculum in hippocampal tissue from schizophrenic subjects. No such differences were found in the dentate gyrus or CA2 region from schizophrenia subjects or in any hippocampal region from bipolar subjects. The lack of change in the bipolar cohort suggests that the decreased density of hippocampal 5-HT 2A receptors is disease specific and not a result of neuroleptic treatment, which both cohorts received. Copyright (2001) Australian Neuroscience Society

  9. Comparisons and Uncertainty in Fat and Adipose Tissue Estimation Techniques: The Northern Elephant Seal as a Case Study.

    Directory of Open Access Journals (Sweden)

    Lisa K Schwarz

    Full Text Available Fat mass and body condition are important metrics in bioenergetics and physiological studies. They can also link foraging success with demographic rates, making them key components of models that predict population-level outcomes of environmental change. Therefore, it is important to incorporate uncertainty in physiological indicators if results will lead to species management decisions. Maternal fat mass in elephant seals (Mirounga spp can predict reproductive rate and pup survival, but no one has quantified or identified the sources of uncertainty for the two fat mass estimation techniques (labeled-water and truncated cones. The current cones method can provide estimates of proportion adipose tissue in adult females and proportion fat of juveniles in northern elephant seals (M. angustirostris comparable to labeled-water methods, but it does not work for all cases or species. We reviewed components and assumptions of the technique via measurements of seven early-molt and seven late-molt adult females. We show that seals are elliptical on land, rather than the assumed circular shape, and skin may account for a high proportion of what is often defined as blubber. Also, blubber extends past the neck-to-pelvis region, and comparisons of new and old ultrasound instrumentation indicate previous measurements of sculp thickness may be biased low. Accounting for such differences, and incorporating new measurements of blubber density and proportion of fat in blubber, we propose a modified cones method that can isolate blubber from non-blubber adipose tissue and separate fat into skin, blubber, and core compartments. Lastly, we found that adipose tissue and fat estimates using tritiated water may be biased high during the early molt. Both the tritiated water and modified cones methods had high, but reducible, uncertainty. The improved cones method for estimating body condition allows for more accurate quantification of the various tissue masses and may

  10. Seals and sealing handbook

    CERN Document Server

    Flitney, Robert K

    2014-01-01

    Seals and Sealing Handbook, 6th Edition provides comprehensive coverage of sealing technology, bringing together information on all aspects of this area to enable you to make the right sealing choice. This includes detailed coverage on the seals applicable to static, rotary and reciprocating applications, the best materials to use in your sealing systems, and the legislature and regulations that may impact your sealing choices. Updated in line with current trends this updated reference provides the theory necessary for you to select the most appropriate seals for the job and with its 'Failur

  11. Tissue Distribution of Polychlorinated Biphenyls and Organochlorine Pesticides and Potential Toxicity to Alaskan Northern Fur Seals Assessed Using PCBs Congener Specific Mode of Action Schemes

    Science.gov (United States)

    The concentrations of 145 polychlorinated biphenyl (PCB) congeners were measured using gas chromatography-ion trap mass spectrometry in 8 different tissues (blubber, brain, heart, kidney, liver, lung, muscle, and reproductive tissues) of 10 Alaskan northern fur seals. The mean concentrations of bot...

  12. Effects of a tissue sealing-cutting device versus monopolar electrocautery on early pilonidal wound healing: a prospective randomized controlled trial.

    Science.gov (United States)

    Parlakgumus, Alper; Ezer, Ali; Caliskan, Kenan; Emeksiz, Servet; Karakaya, Jale; Colakoglu, Tamer; Belli, Sedat; Yildirim, Sedat

    2011-09-01

    Monopolar electrocauterization produces thermal effects on neighboring tissues, causing tissue damage. Recently, tissue sealing-cutting devices, which are easy to use and achieve simultaneous selective sealing and cutting with less production of heat, have been used. The aim of this study was to investigate the effects of a tissue sealing-cutting device vs monopolar electrocautery on wound healing in the early postoperative period after pilonidal sinus surgery. This study was a prospective randomized clinical trial. This study was conducted at Military Hospital, Eskisehir, Turkey. In total, 128 patients with chronic pilonidal disease were randomly assigned into 2 clinically comparable groups between December 2009 and June 2010. Pilonidal sinus excision was performed with monopolar electrocautery in the control group (n = 64) and with a tissue sealing-cutting device in the study group (n = 64). Data regarding wound healing, demographic variables, history, physical examination findings, defect dimensions, and scores for a visual analog scale were recorded. The main outcomes measured were surgical site infection, early wound failure (dehiscence), and unhealed wound rate. : Wound infection and dehiscence rates were significantly lower (P = .01 and .02), but the duration of surgery was significantly longer (P cutting group. The unhealed wound rate was 12.5% in the electrocautery group and 4.7% in the tissue sealing-cutting group (P = .01). When the distance from the lowest margin to the anus was 5 cm or less, wound infection and dehiscence rates were lower in the tissue sealing-cutting group (P cutting device in pilonidal sinus surgery yields better wound healing than monopolar electrocautery.

  13. Macro-analytical methods used to analyze tissues of the Hawaiian monk seal, Monachus schauinslandi, for organochlorine pesticides, polychlorobiphenyls, and pentachlorophenol

    Energy Technology Data Exchange (ETDEWEB)

    Takei, G.H.; Leong, G.H.

    1981-10-01

    Among the specimens which were processed as the results of poisoning incidents, were tissues of an adult male Hawaiian monk seal, Monachus schauinslandi, which had died while in captivity without known cause. Various tissues of the animal were analyzed to determine whether the death of the monk seal had any connection with exposures to environmental pesticides or pollutants, particularly to organochlorine compounds. The specimens included urine, parts of liver, lung and blubber, an entire testis, and an entire kidney. Solid tissues from the animal were from correspondingly large organs. Macro methods for representative analyses of these tissues for multiresidues of organochlorine pesticides, polychlorobiphenyls (PCBs) and pentachlorophenol (PCP) were devised. Results are tabulated. The death of the Hawaiian monk seal could not be attributed conclusively to the organochlorines and pentachlorophenol that were found in tissues of this mammal. Baseline (normal) data of residue levels for these pollutants in animal tissues in Hawaii are so limited that pathogenic levels in the fauna cannot be predicted. It is difficult to even speculate whether the residues detected in the monk seal tissues were due to exposures of earth's background (ambient) atmosphere or to exposures of the mammal's immediate (specific) environment.

  14. Endoscopic Sealing of Bronchopleural Fistulas with Submucosal Injection of a Tissue Expander: A Novel Technique

    Directory of Open Access Journals (Sweden)

    Cayo García-Polo

    2010-01-01

    Full Text Available The occurrence of a bronchopleural fistula (BPF continues to represent a challenging management problem, and is associated with high morbidity and mortality. A novel and successful technique that uses submucosal injection of a tissue expander for bronchoscopic occlusion of BPFs has been designed. This method may be used either alone or in combination with bronchoscopic instillation of n-butyl-cyanoacrylate glue. The occlusion technique is described, with a presentation of two patients who were successfully treated with this method. The submucosal injection of a tissue expander is an effective, economical and minimally invasive technique for managing BPFs.

  15. Seals and sealing handbook

    CERN Document Server

    Flitney, Robert K

    2007-01-01

    Wherever machinery operates there will be seals of some kind ensuring that the machine remains lubricated, the fluid being pumped does not leak, or the gas does not enter the atmosphere. Seals are ubiquitous, in industry, the home, transport and many other places. This 5th edition of a long-established title covers all types of seal by application: static, rotary, reciprocating etc. The book bears little resemblance to its predecessors, and Robert Flitney has re-planned and re-written every aspect of the subject. No engineer, designer or manufacturer of seals can afford to be without this uniq

  16. A Reversibly Sealed, Easy Access, Modular (SEAM Microfluidic Architecture to Establish In Vitro Tissue Interfaces.

    Directory of Open Access Journals (Sweden)

    Vinay V Abhyankar

    Full Text Available Microfluidic barrier tissue models have emerged as advanced in vitro tools to explore interactions with external stimuli such as drug candidates, pathogens, or toxins. However, the procedures required to establish and maintain these systems can be challenging to implement for end users, particularly those without significant in-house engineering expertise. Here we present a module-based approach that provides an easy-to-use workflow to establish, maintain, and analyze microscale tissue constructs. Our approach begins with a removable culture insert that is magnetically coupled, decoupled, and transferred between standalone, prefabricated microfluidic modules for simplified cell seeding, culture, and downstream analysis. The modular approach allows several options for perfusion including standard syringe pumps or integration with a self-contained gravity-fed module for simple cell maintenance. As proof of concept, we establish a culture of primary human microvascular endothelial cells (HMVEC and report combined surface protein imaging and gene expression after controlled apical stimulation with the bacterial endotoxin lipopolysaccharide (LPS. We also demonstrate the feasibility of incorporating hydrated biomaterial interfaces into the microfluidic architecture by integrating an ultra-thin (< 1 μm, self-assembled hyaluronic acid/peptide amphiphile culture membrane with brain-specific Young's modulus (~ 1kPa. To highlight the importance of including biomimetic interfaces into microscale models we report multi-tiered readouts from primary rat cortical cells cultured on the self-assembled membrane and compare a panel of mRNA targets with primary brain tissue signatures. We anticipate that the modular approach and simplified operational workflows presented here will enable a wide range of research groups to incorporate microfluidic barrier tissue models into their work.

  17. No effect of bipolar interferential electrotherapy and pulsed ultrasound for soft tissue shoulder disorders: a randomised controlled trial

    Science.gov (United States)

    van der Heijden, G. J M G; Leffers, P.; Wolters, P.; Verheijden, J.; van Mameren, H.; Houben, J.; Bouter, L.; Knipschild, P.

    1999-01-01

    OBJECTIVE—To assess the efficacy of bipolar interferential electrotherapy (ET) and pulsed ultrasound (US) as adjuvants to exercise therapy for soft tissue shoulder disorders (SD).
METHODS—Randomised placebo controlled trial with a two by two factorial design plus an additional control group in 17 primary care physiotherapy practices in the south of the Netherlands. Patients with shoulder pain and/or restricted shoulder mobility, because of a soft tissue impairment without underlying specific or generalised condition, were enrolled if they had not recovered after six sessions of exercise therapy in two weeks. They were randomised to receive (1) active ET plus active US; (2) active ET plus dummy US; (3) dummy ET plus active US; (4) dummy ET plus dummy US; or (5) no adjuvants. Additionally, they received a maximum of 12 sessions of exercise therapy in six weeks. Measurements at baseline, 6 weeks and 3, 6, 9, and 12 months later were blinded for treatment. Outcome measures: recovery, functional status, chief complaint, pain, clinical status, and range of motion.
RESULTS—After written informed consent 180 patients were randomised: both the active treatments were given to 73 patients, both the dummy treatments to 72 patients, and 35 patients received no adjuvants. Prognosis of groups appeared similar at baseline. Blinding was successfully maintained. At six weeks seven patients (20%) without adjuvants reported very large improvement (including complete recovery), 17 (23%) and 16 (22%) with active and dummy ET, and 19 (26%) and 14 (19%) with active and dummy US. These proportions increased to about 40% at three months, but remained virtually stable thereafter. Up to 12 months follow up the 95% CI for differences between groups for all outcomes include zero.
CONCLUSION—Neither ET nor US prove to be effective as adjuvants to exercise therapy for soft tissue SD.

 PMID:10460185

  18. Bipolar Disorder

    Science.gov (United States)

    Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go ... The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in families. ...

  19. Air atmospheric-pressure plasma-jet treatment enhances the attachment of human gingival fibroblasts for early peri-implant soft tissue seals on titanium dental implant abutments.

    Science.gov (United States)

    Lee, Jung-Hwan; Kim, Yong-Hee; Choi, Eun-Ha; Kim, Kwang-Mahn; Kim, Kyoung-Nam

    2015-01-01

    Although dental implants are commonly used for tooth restoration, there is a lack of studies of treatment regimens for preventing extra-oral infection and decreasing osseointegration failures by establishing early peri-implant soft tissue seals on titanium dental implant abutments. In this study, air atmospheric-pressure plasma-jet (AAPPJ) treatment was applied to titanium disks to assay the potential for early peri-implant soft tissue seals on titanium dental implant abutment. After titanium disks were treated with AAPPJ for 10 s at 250, 500, 1000 and 1500 sccm, surface analysis was performed; the control group received air only or no treatment. Human gingival fibroblasts (HGF) were seeded onto the specimens for evaluating cell attachment and proliferation and adherent-cell morphology was visualized via confocal microscopy. In AAPPJ-treated specimens, the water contact angle decreased according to increased flow rate. Oxygen composition increased in XPS, but no topographical changes were detected. The effect of AAPPJ treatment at 1000 sccm was apparent 2 mm from the treated spot, with a 20% increase in early cell attachment and proliferation. Adherent HGF on AAPPJ-treated specimens displayed a stretched phenotype with more vinculin formation than the control group. Within the limitations of this study, the results indicate that AAPPJ treatment may enhance the early attachment and proliferation of HGF for establishing early peri-implant soft tissue seals on titanium dental implant abutments with possible favorable effects of osseointegration of dental implant.

  20. Glass sealing

    Energy Technology Data Exchange (ETDEWEB)

    Brow, R.K.; Kovacic, L.; Chambers, R.S. [Sandia National Labs., Albuquerque, NM (United States)

    1996-04-01

    Hernetic glass sealing technologies developed for weapons component applications can be utilized for the design and manufacture of fuel cells. Design and processing of of a seal are optimized through an integrated approach based on glass composition research, finite element analysis, and sealing process definition. Glass sealing procedures are selected to accommodate the limits imposed by glass composition and predicted calculations.

  1. TISSUE DISTRIBUTION OF PCBS AND ORGANOCHLORINE PESTICIDES IN ALASKAN NORTHERN FUR SEALS: COMPARISON OF VARIOUS CONGENER CLASSIFICATION SCHEMES

    Science.gov (United States)

    Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are believed to adversely affect reproduction and cause health problems in Pinnipeds 1-4. In this study, 145 PCB congeners and OCPs were analyzed in 10 juvenile male northern fur seals, Callorhinus ursinus, collected from Alaskan...

  2. Mechanical seals

    CERN Document Server

    Mayer, E

    1977-01-01

    Mechanical Seals, Third Edition is a source of practical information on the design and use of mechanical seals. Topics range from design fundamentals and test rigs to leakage, wear, friction and power, reliability, and special designs. This text is comprised of nine chapters; the first of which gives a general overview of seals, including various types of seals and their applications. Attention then turns to the fundamentals of seal design, with emphasis on six requirements that must be considered: sealing effectiveness, length of life, reliability, power consumption, space requirements, and c

  3. Security seal

    Science.gov (United States)

    Gobeli, Garth W.

    1985-01-01

    Security for a package or verifying seal in plastic material is provided by a print seal with unique thermally produced imprints in the plastic. If tampering is attempted, the material is irreparably damaged and thus detectable. The pattern of the imprints, similar to "fingerprints" are recorded as a positive identification for the seal, and corresponding recordings made to allow comparison. The integrity of the seal is proved by the comparison of imprint identification records made by laser beam projection.

  4. "Why throw away something useful?": Attitudes and opinions of people treated for bipolar disorder and their relatives on organ and tissue donation.

    Science.gov (United States)

    Padoan, Carolina S; Garcia, Lucas F; Rodrigues, Aline A; Patusco, Lucas M; Atz, Mariana V; Kapczinski, Flavio; Goldim, José R; Magalhães, Pedro V S

    2017-03-01

    In regard to mental illness, brain donation is essential for the biological investigation of central pathology. Nevertheless, little is known about the thoughts of people with mental disorders on tissue donation for research. Here, our objective was to understand the attitudes and opinions of people treated for bipolar disorder and their relatives regarding donation in general, and particularly donation for research. This is a qualitative study that used in-depth interviews to determine the thoughts of participants regarding tissue donation for research. Theoretical sampling was used as a recruitment method. Grounded theory was used as a framework for content analyses of the interviews. A semi-structured interview guide was applied with the topics: donation in general; donation for research; mental health and body organs; opinion regarding donation; feelings aroused by the topic. Although all participants were aware of organ donation for transplant, they were surprised that tissue could be donated for research. Nevertheless, once they understood the concept they were usually in favor of the idea. Although participants demonstrated a general lack of knowledge on donation for research, they were willing to learn more and viewed it as a good thing, with altruistic reasons often cited as a motive for donation. We speculate that bridging this knowledge gap may be a fundamental step towards a more ethical postmortem tissue donation process.

  5. Bipolar disorder

    Science.gov (United States)

    ... of pleasure in activities once enjoyed Loss of self-esteem Thoughts of death or suicide Trouble getting to ... other. This is called rapid cycling. Exams and Tests To diagnose bipolar disorder, the provider may do ...

  6. Bipolar disorder

    Directory of Open Access Journals (Sweden)

    F Colin

    2013-08-01

    Full Text Available Bipolar disorder (BD presents in different phases over time and is oftencomplicated by comorbid conditions such as substance-use disordersand anxiety disorders. Treatment usually involves pharmacotherapywith combinations of different classes of medications and frequentmedication revisions.

  7. Nozzle seal

    International Nuclear Information System (INIS)

    Groff, R.D.; Vatovec, R.J.

    1978-01-01

    In an illustrative embodiment of the invention, a nuclear reactor pressure vessel, having an internal hoop from which the heated coolant emerges from the reactor core and passes through to the reactor outlet nozzles, is provided with annular sealing members operatively disposed between the outlet nozzle and the hoop and partly within a retaining annulus formed in the hoop. The sealing members are biased against the pressure vessel and the hoop and one of the sealing members is provided with a piston type pressure ring sealing member which effectively closes the path between the inlet and outlet coolants in the region about the outlet nozzle establishing a leak-proof condition. Furthermore, the flexible responsiveness of the seal assures that the seal will not structurally couple the hoop to the pressure vessel

  8. Comparative investigation of viability, metabolism and osteogenic capability of tissue-engineered bone preserved in sealed osteogenic media at 37 {sup 0}C and 4 {sup 0}C

    Energy Technology Data Exchange (ETDEWEB)

    Wang Hengjian; Liu Guangpeng; Zhou Guangdong; Cen Lian; Cui Lei; Cao Yilin, E-mail: cuileite@yahoo.com.c, E-mail: yilincao@yahoo.co [Department of Plastic and Reconstructive Surgery, Shanghai 9th People' s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011 (China)

    2010-06-01

    Preservation of tissue-engineered (TE) bone is one of the key problems needed to be solved for its clinic application and industrialization. Traditional cryopreservation has been restricted because of the damages caused by ice formation and solution. Hypothermic preservation at 4 {sup 0}C has been widely used for the preservation of transplanted organ despite potential negative effects on viability of cells and tissue. 37 {sup 0}C is the best temperature for maintaining cellular bioactivities. However, 37 {sup 0}C also has a potential negative effect on preserved cells due to consumption of nutrients and accumulation of by-products. No studies have reported which temperature is more suitable for the preservation of TE bone constructs. The current study explored the feasibility of preservation of TE bone constructs in sealed osteogenic media at 37 {sup 0}C and 4 {sup 0}C. Human bone marrow stromal cells (hBMSCs) were seeded into partially demineralized bone matrix (pDBM) scaffolds and cultured for 7 days to form TE bone constructs. The constructs were preserved in sealed osteogenic media at either 37 {sup 0}C or 4 {sup 0}C for 5, 7, 9 and 11 days, respectively. Growth kinetics, viability, metabolism and osteogenic capability were evaluated to explore the feasibility of preservation at 37 {sup 0}C and 4 {sup 0}C. The constructs cultured in osteogenic media at humidified 37 {sup 0}C/5%CO{sub 2} served as the positive control. The results demonstrated that all the constructs preserved at 4 {sup 0}C showed negative osteogenic capability at all time points with a much lower level of growth kinetics, viability and metabolism compared to the positive control. However, the constructs preserved at 37 {sup 0}C showed good osteogenic capability within 7 days with a certain level of growth kinetics, viability and metabolism, although an obvious decrease in osteogenic capability was observed in the constructs preserved at 37 {sup 0}C over 9 days. These results indicate that the

  9. Ferrules seals

    Science.gov (United States)

    Smith, J.L.

    1984-07-10

    A device is provided for sealing an inner tube and an outer tube without excessively deforming the tubes. The device includes two ferrules which cooperate to form a vacuum-tight seal between the inner tube and outer tube and having mating surfaces such that overtightening is not possible. 3 figs.

  10. Ceramic Seal.

    Energy Technology Data Exchange (ETDEWEB)

    Smartt, Heidi A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Romero, Juan A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Custer, Joyce Olsen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hymel, Ross W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Krementz, Dan [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Gobin, Derek [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Harpring, Larry [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Martinez-Rodriguez, Michael [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Varble, Don [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); DiMaio, Jeff [Tetramer Technologies, Pendleton, SC (United States); Hudson, Stephen [Tetramer Technologies, Pendleton, SC (United States)

    2016-11-01

    Containment/Surveillance (C/S) measures are critical to any verification regime in order to maintain Continuity of Knowledge (CoK). The Ceramic Seal project is research into the next generation technologies to advance C/S, in particular improving security and efficiency. The Ceramic Seal is a small form factor loop seal with improved tamper-indication including a frangible seal body, tamper planes, external coatings, and electronic monitoring of the seal body integrity. It improves efficiency through a self-securing wire and in-situ verification with a handheld reader. Sandia National Laboratories (SNL) and Savannah River National Laboratory (SRNL), under sponsorship from the U.S. National Nuclear Security Administration (NNSA) Office of Defense Nuclear Nonproliferation Research and Development (DNN R&D), have previously designed and have now fabricated and tested Ceramic Seals. Tests have occurred at both SNL and SRNL, with different types of tests occurring at each facility. This interim report will describe the Ceramic Seal prototype, the design and development of a handheld standalone reader and an interface to a data acquisition system, fabrication of the seals, and results of initial testing.

  11. Ferrules seals

    Science.gov (United States)

    Smith, James L.

    1984-01-01

    A device is provided for sealing an inner tube and an outer tube without excessively deforming the tubes. The device includes two ferrules which cooperate to form a vacuum-tight seal between the inner tube and outer tube and having mating surfaces such that overtightening is not possible.

  12. Sealing devices

    International Nuclear Information System (INIS)

    Coulson, R.A.

    1980-01-01

    A sealing device for minimising the leakage of toxic or radioactive contaminated environments through a biological shield along an opening through which a flexible component moves that penetrates the shield. The sealing device comprises an outer tubular member which extends over a length not less than the maximum longitudinal movement of the component along the opening. An inner sealing block is located intermediate the length of the component by connectors and is positioned in the bore of the outer tubular member to slide in the bore and effect a seal over the entire longitudinal movement of the component. The cross-section of the device may be circular and the block may be of polytetrafluoroethylene or of nylon impregnated with molybdenum or may be metallic. A number of the sealing devices may be combined into an assembly for a plurality of adjacent longitudinally movable components, each adapted to sustain a tensile load, providing the various drives of a master-slave manipulator. (author)

  13. Morphological Changes in the state of dental tissues in the treatment of deep caries with dentin-sealing liquid and low-intensity laser radiation (clinical and experimental research)

    OpenAIRE

    Kovaleva, M.; Britova, A.

    2011-01-01

    The article shows the results of morphological studies of dental hard tissues after the application of methods of treatment of deep caries with dentin-sealing liquid and low-intensity laser therapy. This new method is preventive measure against repeated and recurrent caries.

  14. Seal Counts

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Database of seal counts from aerial photography. Counts by image, site, species, and date are stored in the database along with information on entanglements and...

  15. [Christmas seals].

    Science.gov (United States)

    Loytved, G

    2006-11-01

    Christmas seals, i. e., special stamps used to decorate or seal Christmas and New Year's mail, were created by the Danish post office clerk E. Holboell. The proceeds from the sale of the stickers were meant to alleviate the suffering of children sick with tuberculosis. The first Christmas seal, showing a portrait of Queen Louise of Denmark, was issued on December 10, 1904. The demand at the post office was enormous. The funds raised exceeded all expectations and made it possible to finance the construction of a sanatorium for tuberculosis children. The idea of Christmas seals spread quickly around the world and ended up being copied in 130 countries. At the beginning of the 20 (th) century, the small stamp with the red double-barred cross became a banner for the crusade against tuberculosis. For many patients, it also represented a symbol of hope for recovery even though this hope, given the cure rates of a sanatorium treatment, only became a reality for a few. Worldwide, Christmas seals were and are colourful and imaginatively designed, mostly with Christmas symbols or motives relating to the fight against tuberculosis. The funds raised through the sale of the seals initially helped to build hospitals and were later also used to screen persons at risk for tuberculosis, to improve housing conditions of patients and for other measures of support. With the decrease of tuberculosis, some organisations discontinued fundraising through Christmas seals while others widened their intended purpose and supported, for example, the prevention of and research on lung diseases. In Germany, Christmas seals are closely connected with the German Central Committee against Tuberculosis. Today the "Kuratorium Tuberkulose in der Welt" is the only organisation in this country that still raises funds by this means. The funds are mostly used to assist developing countries with a high burden of tuberculosis.

  16. Bipolar Disorder (For Teens)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Bipolar Disorder KidsHealth / For Teens / Bipolar Disorder What's in this ... Disorder Print en español Trastorno bipolar What Is Bipolar Disorder? Bipolar disorders are one of several medical conditions ...

  17. Neutrality in bipolar structures

    DEFF Research Database (Denmark)

    Montero, Javier; Rodríguez, J. Tinguaro; Franco, Camilo

    2014-01-01

    In this paper, we want to stress that bipolar knowledge representation naturally allows a family of middle states which define as a consequence different kinds of bipolar structures. These bipolar structures are deeply related to the three types of bipolarity introduced by Dubois and Prade, but our...... approach offers a systematic explanation of how such bipolar structures appear and can be identified....

  18. Microradiographic investigations on experimentally provoked structural alterations in hard tooth tissues after sealing with plastic material in places where caries is apt to develop

    International Nuclear Information System (INIS)

    Falten, E.

    1981-01-01

    The aim of the present investigation was, after sealing three areas in extracted human teeth: fissures, dental necksand approximate areas and subsequent exposure to experimentally produced cariogenous noxae, to establish possible alterations in the area of transition between sealed and unsealed dental enamal. This would provide a further decision-taking aid with regard to the question whether also the remaining parts where caries is apt to develop should be sealed. (orig./MG) [de

  19. What is Bipolar Disorder?

    Science.gov (United States)

    ... affect friends and family? For More Information Share Bipolar Disorder Download PDF Download ePub Order a free hardcopy ... brochure will give you more information. What is bipolar disorder? Bipolar disorder is a serious brain illness. It ...

  20. Transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Alda Martin

    1999-01-01

    Full Text Available Os resultados de estudos de famílias sugerem que o transtorno bipolar tenha uma base genética. Essa hipótese foi reforçada em estudos de adoção e de gêmeos. A herança do transtorno bipolar é complexa, envolve vários genes, além de apresentar heterogeneidade e interação entre fatores genéticos e não-genéticos. Achados, que já foram replicados, já implicaram os cromossomos 4, 12, 18 e 21, entre outros, na busca por genes de suscetibilidade. Os resultados mais promissores foram obtidos através de estudos de ligação. Por outro lado, os estudos de associação geraram dados interessantes, mas ainda vagos. Os estudos de populações de pacientes homogêneos e a melhor definição do fenótipo deverão contribuir para avanços futuros. A identificação dos genes relacionados ao transtorno bipolar irá permitir o melhor entendimento e tratamento dessa doença.

  1. "Birdlime" technique using TachoSil tissue sealing sheet soaked with fibrin glue for sutureless vessel transposition in microvascular decompression: operative technique and nuances.

    Science.gov (United States)

    Otani, Naoki; Toyooka, Terushige; Fujii, Kazuya; Kumagai, Kosuke; Takeuchi, Satoru; Tomiyama, Arata; Nakao, Yasuaki; Yamamoto, Takuji; Wada, Kojiro; Mori, Kentaro

    2017-08-11

    OBJECTIVE Microvascular decompression (MVD) is effective for the treatment of trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia. The transposition technique is the standard procedure to avoid adhesions and granuloma around the decompression site but is more complex and difficult to perform than the interposition technique. The authors describe a simple and safe MVD transposition procedure they call the "birdlime" technique, which uses a tissue glue-coated collagen sponge soaked with fibrin glue, and the results of this technique. METHODS The authors retrospectively reviewed the medical charts and radiographic findings of 27 consecutive patients with TN (8 patients) and HFS (19 patients) who, between January 2012 and December 2015, had undergone an MVD transposition procedure utilizing a tissue glue-coated collagen sponge (TachoSil tissue sealing sheet) soaked with fibrin glue (Tisseel 2-component fibrin sealant, vapor heated). Offending arteries among the patients with TN were the superior cerebellar artery (SCA) in 5 patients, the SCA and anterior inferior cerebellar artery (AICA) in 2, and the AICA in 1. Those among the patients with HFS were the vertebral artery (VA) in 3 patients, the VA and AICA in 4, the VA and posterior inferior cerebellar artery (PICA) in 3, the PICA in 4, the AICA in 1, the AICA-PICA in 3, and the PICA and AICA in 1. Operations were performed according to the Jannetta procedure. The offending artery was transposed and fixed to the dura mater of the petrous bone using TachoSil pieces soaked with fibrin glue. Postoperative constructive interference in steady-state MRI was performed to evaluate the change in the position of the offending artery. RESULTS Transposition of the offending artery was easily and safely performed in all patients. All patients had total remission of symptoms directly after the procedure. No severe complications occurred. The postoperative course was uneventful. No recurrences, adhesions

  2. Analysis of thyroid hormones in serum of Baikal seals and humans by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassay methods: application of the LC-MS/MS method to wildlife tissues.

    Science.gov (United States)

    Kunisue, Tatsuya; Eguchi, Akifumi; Iwata, Hisato; Tanabe, Shinsuke; Kannan, Kurunthachalam

    2011-12-01

    Thyroid hormones (THs) are essential for the regulation of growth and development in both humans and wildlife. Until recently, TH concentrations in the tissues of animals have been examined by immunoassay (IA) methods. IA methods are sensitive, but for TH analysis, they are compromised by a lack of adequate specificity. In this study, we determined the concentrations of six THs, L-thyroxine (T(4)), 3,3',5-triiodo-L-thyronine (T(3)), 3,3',5'-triiodo-L-thyronine (rT(3)), 3,5-diiodo-L-thyronine (3,5-T(2)), 3,3'-diiodo-L-thyronine (3,3'-T(2)), and 3-iodo-L-thyronine (3-T(1)), in the serum of humans (n = 79) and wild Baikal seals (n = 37), by isotope ([(13)C(6)]-T(4))-dilution liquid chromatography (LC)-tandem mass spectrometry (MS/MS), and compared the TH levels with those measured by an electrochemiluminescent immunoassay (ECLIA) method. T(3) and T(4) were detected in all serum samples of both humans and Baikal seals, whereas T(1), 3,3'-T(2), and 3,5-T(2) were below the limit of detection (LOD). rT(3) was detected in Baikal seal sera at concentrations higher than T(3) in 28 seal samples, indicating an anomaly in deiodinase activity in Baikal seals. In humans, regression analyses of TH concentrations, measured by ECLIA and LC-MS/MS methods, showed significant correlations for T(4) (r = 0.852) and T(3) (r = 0.676; after removal of a serum sample with abnormal T(3) levels). In Baikal seals, a low correlation coefficient (r = 0.466) for T(4) levels and no correlation for T(3) levels (p = 0.093) were found between ECLIA and LC-MS/MS methods. These results suggest that interference by a nonspecific reaction against anti-T(3) and anti-T(4) antibodies used in the ECLIA can contribute to inaccuracies in TH measurement in Baikal seals. When the relationship between concentrations of THs in sera and dioxin-like toxic equivalents in blubber samples of Baikal seals (n = 19) was examined, a significantly negative correlation was found for serum T(4) levels measured by the LC

  3. Bipolar disorder: an overview

    African Journals Online (AJOL)

    which is the reason that up to 69% of patients with BD are misdiagnosed.1 Bipolar ... Cyclothymic disorder. • Substance/medication induced bipolar and related disorder. • Bipolar and related disorder due to another medical condition ... patients. Keywords: bipolar disorder, mania, depression, pharmacological management.

  4. Bipolar Items

    Directory of Open Access Journals (Sweden)

    Nishiguchi Sumiyo

    2016-12-01

    Full Text Available This article asserts that the Japanese wide-scope mo ‘even’ in simple sentences are bipolar items (BPIs antilicensed or forbidden by negation and licensed in a non-monotonic (NM environment. BPIs share the features of negative polarity items (NPIs as well as positive polarity items (PPIs. The Dutch ooit ‘ever’, the Serbo-Croatian i-series ‘and/even’, and the Hungarian is-series ‘and/even’ are antilicensed by clausemate negation and licensed by extraclausal negation (van der Wouden, 1997; Progovac, 1994; Szabolcsi, 2002 or non-monotonic negative (and positive, for Serbo-Croatian emotive predicates. Adding an NPI rescues BPIs in uncomfortable clausemate negation.

  5. Types of Bipolar Disorder

    Science.gov (United States)

    ... many people have bipolar disorder along with another illness such as anxiety disorder, substance abuse, or an eating disorder. People with ... are sometimes misdiagnosed with schizophrenia. Anxiety and ADHD: ... such as bipolar disorder. Risk Factors Scientists are ...

  6. Cytokines in bipolar disorder

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Vinberg, Maj; Vedel Kessing, Lars

    2012-01-01

    to affective state. METHODS: We conducted a systemtic review of studies measuring endogenous cytokine concentrations in patients with bipolar disorder and a meta-analysis, reporting results according to the PRISMA statement. RESULTS: Thirteen studies were included, comprising 556 bipolar disorder patients......BACKGROUND: Current research and hypothesis regarding the pathophysiology of bipolar disorder suggests the involvement of immune system dysfunction that is possibly related to disease activity. Our objective was to systematically review evidence of cytokine alterations in bipolar disorder according...

  7. Psychotic and Bipolar Disorders: Bipolar Disorder.

    Science.gov (United States)

    Holder, Sarah D

    2017-04-01

    Bipolar disorder is a severe chronic mental illness that affects a large number of individuals. This disorder is separated into two major types, bipolar I disorder, with mania and typically recurrent depression, and bipolar II disorder, with recurrent major depression and hypomania. Patients with bipolar disorder spend the majority of time experiencing depression, and this typically is the presenting symptom. Because outcomes are improved with earlier diagnosis and treatment, physicians should maintain a high index of suspicion for bipolar disorder. The most effective long-term treatments are lithium and valproic acid, although other drugs also are used. In addition to referral to a mental health subspecialist for initiation and management of drug treatment, patients with bipolar disorder should be provided with resources for psychotherapy. Several comorbidities commonly associated with bipolar disorder include other mental disorders, substance use disorders, migraine headaches, chronic pain, stroke, metabolic syndrome, and cardiovascular disease. Family physicians who care for patients with bipolar disorder should focus their efforts on prevention and management of comorbidities. These patients should be assessed continually for risk of suicide because they are at high risk and their suicide attempts tend to be successful. Written permission from the American Academy of Family Physicians is required for reproduction of this material in whole or in part in any form or medium.

  8. Nutrition and Bipolar Depression.

    Science.gov (United States)

    Beyer, John L; Payne, Martha E

    2016-03-01

    As with physical conditions, bipolar disorder is likely to be impacted by diet and nutrition. Patients with bipolar disorder have been noted to have relatively unhealthy diets, which may in part be the reason they also have an elevated risk of metabolic syndrome and obesity. An improvement in the quality of the diet should improve a bipolar patient's overall health risk profile, but it may also improve their psychiatric outcomes. New insights into biological dysfunctions that may be present in bipolar disorder have presented new theoretic frameworks for understanding the relationship between diet and bipolar disorder. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Bipolar Treatment: Are Bipolar I and Bipolar II Treated Differently?

    Science.gov (United States)

    ... management strategies. In addition to medications and other types of treatment, successful management of your bipolar disorder includes living a healthy lifestyle, such as getting enough sleep, eating a healthy diet and being physically active. ...

  10. New generation cut-and-seal devices in oral and oropharyngeal cancer resection: clinical and cost-effectiveness study.

    Science.gov (United States)

    Tirelli, G; Del Piero, G C; Valentinuz, G; Monte, A; Gatto, A; Rebelli, A; Quatela, E

    2017-12-18

    To evaluate the clinical efficacy and cost-effectiveness of ultrasonic shears and the electrothermal bipolar vessel sealing system, in comparison to the traditional cold knife and bipolar forceps, in oral and oropharyngeal cancer surgery. Patients who underwent oral or oropharyngeal cancer resection and neck dissection with either ultrasonic shears (n = 36) or electrothermal bipolar vessel sealing (n = 32) were enrolled. Surgical time, intra-operative bleeding, blood drainage, post-operative pain, neck oedema, complications and hospitalisation duration were compared to those of an historical cohort of 36 patients treated using a cold knife and bipolar forceps. Additionally, a cost-effectiveness evaluation was performed. Ultrasonic shears and, in particular, electrothermal bipolar vessel sealing, were advantageous compared to the traditional techniques. The cost of ultrasonic shears and electrothermal bipolar vessel sealing was completely offset by declining time-driven costs for the surgical team and operating theatre. Ultrasonic shears and, in particular, electrothermal bipolar vessel sealing, are more advantageous compared to the traditional techniques, from both a clinical and economic point of view.

  11. Mechanical Seal Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Kotlyar, Oleg M.

    1999-06-18

    An improved mechanical seal assembly is provided for sealing rotating shafts with respect to their shaft housings, wherein the rotating shafts are subject to substantial axial vibrations. The mechanical seal assembly generally includes a rotating sealing ring fixed to the shaft, a non-rotating sealing ring adjacent to and in close contact with the rotating sealing ring for forming an annular seal about the shaft, and a mechanical diode element that applies a biasing force to the non-rotating sealing ring by means of hemispherical joint. The alignment of the mechanical diode with respect to the sealing rings is maintained by a series of linear bearings positioned axially along a desired length of the mechanical diode. Alternative embodiments include mechanical or hydraulic amplification components for amplifying axial displacement of the non-rotating sealing ring and transferring it to the mechanical diode.

  12. Mechanical seal assembly

    Science.gov (United States)

    Kotlyar, Oleg M.

    2001-01-01

    An improved mechanical seal assembly is provided for sealing rotating shafts with respect to their shaft housings, wherein the rotating shafts are subject to substantial axial vibrations. The mechanical seal assembly generally includes a rotating sealing ring fixed to the shaft, a non-rotating sealing ring adjacent to and in close contact with the rotating sealing ring for forming an annular seal about the shaft, and a mechanical diode element that applies a biasing force to the non-rotating sealing ring by means of hemispherical joint. The alignment of the mechanical diode with respect to the sealing rings is maintained by a series of linear bearings positioned axially along a desired length of the mechanical diode. Alternative embodiments include mechanical or hydraulic amplification components for amplifying axial displacement of the non-rotating sealing ring and transferring it to the mechanical diode.

  13. Seal design alternatives study

    International Nuclear Information System (INIS)

    Van Sambeek, L.L.; Luo, D.D.; Lin, M.S.; Ostrowski, W.; Oyenuga, D.

    1993-06-01

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information

  14. Mechanical seal program

    International Nuclear Information System (INIS)

    Lowery, G.B.

    1983-01-01

    The experimental plans and timing for completion of the mechanical seal program for both the slurry and transfer pumps are given. The slurry pump seal program will be completed by April 1984 with turnover of two seals in pumps to SRP Tank 15H. Transfer pump seal design will be released for plant use by May 1984. Also included are various other pump and seal related tests

  15. Bipolar soft connected, bipolar soft disconnected and bipolar soft compact spaces

    Directory of Open Access Journals (Sweden)

    Muhammad Shabir

    2017-06-01

    Full Text Available Bipolar soft topological spaces are mathematical expressions to estimate interpretation of data frameworks. Bipolar soft theory considers the core features of data granules. Bipolarity is important to distinguish between positive information which is guaranteed to be possible and negative information which is forbidden or surely false. Connectedness and compactness are the most important fundamental topological properties. These properties highlight the main features of topological spaces and distinguish one topology from another. Taking this into account, we explore the bipolar soft connectedness, bipolar soft disconnectedness and bipolar soft compactness properties for bipolar soft topological spaces. Moreover, we introduce the notion of bipolar soft disjoint sets, bipolar soft separation, and bipolar soft hereditary property and study on bipolar soft connected and disconnected spaces. By giving the detailed picture of bipolar soft connected and disconnected spaces we investigate bipolar soft compact spaces and derive some results related to this concept.

  16. Nuclear reactor sealing system

    International Nuclear Information System (INIS)

    McEdwards, J.A.

    1983-01-01

    A liquid metal-cooled nuclear reactor sealing system is disclosed. The nuclear reactor includes a vessel sealed at its upper end by a closure head. The closure head comprises at least two components, one of which is rotatable; and the two components define an annulus therebetween. The sealing system includes at least a first and second inflatable seal disposed in series in an upper portion of the annulus. The system further includes a dip seal extending into a body of insulation located adjacent a bottom portion of the closure head. The dip seal comprises a trough formed by a lower portion of one of the components, and a seal blade pendently supported from the other component and extending downwardly into the trough. A body of liquid metal is contained in the trough which submerges a portion of the seal blade. The seal blade is provided with at least one aperture located above the body of liquid metal for providing fluid communication between the annulus intermediate the dip seal and the inflatable seals, and a body of cover gas located inside the vessel. There also is provided means for introducing a purge gas into the annulus intermediate the inflatable seals and the seal blade. The purge gas is introduced in an amount sufficient to substantially reduce diffusion of radioactive cover gas or sodium vapor up to the inflatable seals. The purge gas mixes with the cover gas in the reactor vessel where it can be withdrawn from the vessel for treatment and recycle to the vessel

  17. Photochemical tissue bonding

    Science.gov (United States)

    Redmond, Robert W [Brookline, MA; Kochevar, Irene E [Charlestown, MA

    2012-01-10

    Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.

  18. Magnetically Actuated Seal Project

    Data.gov (United States)

    National Aeronautics and Space Administration — FTT proposes development of a magnetically actuated dynamic seal. Dynamic seals are used throughout the turbopump in high-performance, pump-fed, liquid rocket...

  19. Seal coat research project

    Science.gov (United States)

    1999-12-01

    This study evaluates the use of seal coating as a method to protect bituminous pavements from oxidation, water infiltration, and raveling. The Minnesota Department of Transportation (Mn/DOT) applied seal coating to a roadway segment of Trunk Highway ...

  20. Magnetically Actuated Seal

    Science.gov (United States)

    Pinera, Alex

    2013-01-01

    This invention is a magnetically actuated seal in which either a single electromagnet, or multiple electromagnets, are used to control the seal's position. This system can either be an open/ close type of system or an actively controlled system.

  1. Reactor vessel sealing plug

    International Nuclear Information System (INIS)

    Dooley, R.A.

    1986-01-01

    This invention relates to an apparatus and method for sealing the cold leg nozzles of a nuclear reactor pressure vessel from a remote location during maintenance and inspection of associated steam generators and pumps while the pressure vessel and refueling canal are filled with water. The apparatus includes a sealing plug for mechanically sealing the cold leg nozzle from the inside of a reactor pressure vessel. The sealing plugs include a primary and a secondary O-ring. An installation tool is suspended within the reactor vessel and carries the sealing plug. The tool telescopes to insert the sealing plug within the cold leg nozzle, and to subsequently remove the plug. Hydraulic means are used to activate the sealing plug, and support means serve to suspend the installation tool within the reactor vessel during installation and removal of the sealing plug

  2. Hermetically Sealed Compressor

    Science.gov (United States)

    Holtzapple, Mark T.

    1994-01-01

    Proposed hermetically sealed pump compresses fluid to pressure up to 4,000 atm (400 MPa). Pump employs linear electric motor instead of rotary motor to avoid need for leakage-prone rotary seals. In addition, linear-motor-powered pump would not require packings to seal its piston. Concept thus eliminates major cause of friction and wear. Pump is double-ended diaphragm-type compressor. All moving parts sealed within compressor housing.

  3. Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs

    Science.gov (United States)

    Alfano, Robert R.; Tang, Jing; Evans, Jonathan M.; Ho, Peng Pei

    2006-04-25

    Laser tissue welding can be achieved using tunable Cr.sup.4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.

  4. Bipolar Disorder - Multiple Languages

    Science.gov (United States)

    ... MP3 Bipolar Disorder (An Introduction) - English MP4 Bipolar Disorder (An Introduction) - español (Spanish) MP4 Healthy Roads Media Characters not displaying correctly on this page? See language display issues . Return to the MedlinePlus Health Information ...

  5. Magnetic bipolar transistor

    OpenAIRE

    Fabian, Jaroslav; Zutic, Igor; Sarma, S. Das

    2003-01-01

    A magnetic bipolar transistor is a bipolar junction transistor with one or more magnetic regions, and/or with an externally injected nonequilibrium (source) spin. It is shown that electrical spin injection through the transistor is possible in the forward active regime. It is predicted that the current amplification of the transistor can be tuned by spin.

  6. Severe service sealing solutions

    International Nuclear Information System (INIS)

    Metcalfe, R.; Wensel, R.

    1994-09-01

    Successful sealing usually requires much more than initial leak-tightness. Friction and wear must also be acceptable, requiring a good understanding of tribology at the sealing interface. This paper describes various sealing solutions for severe service conditions. The CAN2A and CAN8 rotary face seals use tungsten carbide against carbon-graphite to achieve low leakage and long lifetime in nuclear main coolant pumps. The smaller CAN6 seal successfully uses tungsten carbide against silicon carbide in reactor water cleanup pump service. Where friction in CANDU fuelling machine rams must be essentially zero, a hydrostatic seal using two silicon carbide faces is the solution. In the NRU reactor moderator pumps, where pressure is much lower, eccentric seals that prevent boiling at the seal faces are giving excellent service. All these rotary face seals rely on supplementary elastomer seals between their parts. An integrated engineering approach to high performance sealing with O-rings is described. This is epitomized in critical Space Shuttle applications, but is increasingly being applied in CANDU plants. It includes gland design, selection and qualification of material, quality assurance, detection of defects and the effects of lubrication, surface finish, squeeze, stretch and volume constraints. In conclusion, for the severe service applications described, customized solutions have more than paid for themselves by higher reliability, lower maintenance requirements and reduced outage time. (author)

  7. High pressure shaft seal

    International Nuclear Information System (INIS)

    Martinson, A.R.; Rogers, V.D.

    1980-01-01

    In relation to reactor primary coolant pumps, mechanical seal assembly for a pump shaft is disclosed which features a rotating seal ring mounting system which utilizes a rigid support ring loaded through narrow annular projections in combination with centering non-sealing O-rings which effectively isolate the rotating seal ring from temperature and pressure transients while securely positioning the ring to adjacent parts. A stationary seal ring mounting configuration allows the stationary seal ring freedom of motion to follow shaft axial movement up to 3/4 of an inch and shaft tilt about the pump axis without any change in the hydraulic or pressure loading on the stationary seal ring or its carrier. (author)

  8. Properties of Bipolar Fuzzy Hypergraphs

    OpenAIRE

    Akram, M.; Dudek, W. A.; Sarwar, S.

    2013-01-01

    In this article, we apply the concept of bipolar fuzzy sets to hypergraphs and investigate some properties of bipolar fuzzy hypergraphs. We introduce the notion of $A-$ tempered bipolar fuzzy hypergraphs and present some of their properties. We also present application examples of bipolar fuzzy hypergraphs.

  9. Bipolar Disorder in Children

    Science.gov (United States)

    2014-01-01

    Although bipolar disorder historically was thought to only occur rarely in children and adolescents, there has been a significant increase in children and adolescents who are receiving this diagnosis more recently (Carlson, 2005). Nonetheless, the applicability of the current bipolar disorder diagnostic criteria for children, particularly preschool children, remains unclear, even though much work has been focused on this area. As a result, more work needs to be done to further the understanding of bipolar symptoms in children. It is hoped that this paper can assist psychologists and other health service providers in gleaning a snapshot of the literature in this area so that they can gain an understanding of the diagnostic criteria and other behaviors that may be relevant and be informed about potential approaches for assessment and treatment with children who meet bipolar disorder criteria. First, the history of bipolar symptoms and current diagnostic criteria will be discussed. Next, assessment strategies that may prove helpful for identifying bipolar disorder will be discussed. Then, treatments that may have relevance to children and their families will be discussed. Finally, conclusions regarding work with children who may have a bipolar disorder diagnosis will be offered. PMID:24800202

  10. Bipolar Disorder in Children

    Directory of Open Access Journals (Sweden)

    Kimberly Renk

    2014-01-01

    Full Text Available Although bipolar disorder historically was thought to only occur rarely in children and adolescents, there has been a significant increase in children and adolescents who are receiving this diagnosis more recently (Carlson, 2005. Nonetheless, the applicability of the current bipolar disorder diagnostic criteria for children, particularly preschool children, remains unclear, even though much work has been focused on this area. As a result, more work needs to be done to further the understanding of bipolar symptoms in children. It is hoped that this paper can assist psychologists and other health service providers in gleaning a snapshot of the literature in this area so that they can gain an understanding of the diagnostic criteria and other behaviors that may be relevant and be informed about potential approaches for assessment and treatment with children who meet bipolar disorder criteria. First, the history of bipolar symptoms and current diagnostic criteria will be discussed. Next, assessment strategies that may prove helpful for identifying bipolar disorder will be discussed. Then, treatments that may have relevance to children and their families will be discussed. Finally, conclusions regarding work with children who may have a bipolar disorder diagnosis will be offered.

  11. Flexible ring seal

    International Nuclear Information System (INIS)

    Abbes, Claude; Gournier, Andre; Rouaud, Christian; Villepoix, Raymond de.

    1976-01-01

    The invention concerns a flexible metal ring seal, able to ensure a perfect seal between two bearings due to the crushing and elastic deformation properties akin to similar properties in elastomers. Various designs of seal of this kind are already known, particularly a seal made of a core formed by a helical wire spring with close-wound turns and with high axial compression ratio, closed on itself and having the shape of an annulus. This wire ring is surrounded by at least one envelope having at rest the shape of a toroidal surface of which the generating circle does not close on itself. In a particular design mode, the seal in question can include, around the internal spring, two envelopes of which one in contact with the spring is composed of a low ductility elastic metal, such as mild steel or stainless steel and the other is, on the contrary, made of a malleable metal, such as copper or nickel. The first envelope evenly distributes the partial crushing of the spring, when the seal is tightened, on the second envelope which closely fits the two surfaces between which the seal operates. The stress-crushing curve characteristic of the seal comprises two separate parts, the first with a relatively sharp slope corresponds to the start of the seal compression phase, enabling at least some of these curves to reach the requisite seal threshold very quickly, then, beyond this, a second part, practically flat, where the stress is appreciably constant for a wide operating bracket [fr

  12. Seals in nuclear reactors

    International Nuclear Information System (INIS)

    1979-01-01

    The seals described are for use in a nuclear reactor where there are fuel assemblies in a vessel, an inlet and an outlet for circulating a coolant in heat transfer relationship with the fuel assemblies and a closure head on the vessel in a tight fluid relationship. The closure head comprises rotatable plugs which have mechanical seals disposed in the annulus around each plug while allowing free rotation of the plug when the seal is not actuated. The seal is usually an elastomer or copper. A means of actuating the seal is attached for drawing it vertically into the annulus for sealing. When the reactor coolant is liquid sodium, contact with oxygen must be avoided and argon cover gas fills the space between the bottom of the closure head and the coolant liquid level and the annuli in the closure head. (U.K.)

  13. Seals in nuclear reactors

    International Nuclear Information System (INIS)

    1979-01-01

    The aim of this invention is the provision of improved seals for reactor vessels in which fuel assemblies are located together with inlets and outlets for the circulation of a coolant. The object is to provide a seal arrangement for the rotatable plugs of nuclear reactor closure heads which has good sealing capacities over a wide gap during operation of the reactor but which also permits uninhibited rotation of the plugs for maintenance. (U.K.)

  14. Compliant seal development

    Science.gov (United States)

    Hendricks, Robert C.

    1993-10-01

    The compliant metallic seal combines the noncontact feature of the labyrinth seal, the low leakage of a mechanical seal, and the compliant nature of the brush seal. It consists of several thin metallic elements or leaves mounted within a ring which is press fit into the housing, and in form, sort of resembles a lip seal sections wiping the shaft. A second set of overlapping cover leaves are placed on top of the shaft riding leaves which reduces leakage and provides stiffness. The leaves can be straight or angle cut. The shaft riding fingers are designed with mismatched curvature to provide lift off similar to the Rayleigh lift pads in mechanical seals with leading edge clearances nearly twice those of the trailing edge as as shown by Fleming to be optimal for gas flows in convergent seal passages. Leading edge clearances range from 300 to 500 microinches. Balance pockets beneath the leaves provide fluid film feed to the 'Rayleigh lift' surface and the proper balance ratio (mechanical seal) when combined with the static pressure and film pressure. The leaves flex in the radial direction and accommodate thermomechanical behavior as well as axial motion and angular misalignment. In the static mode, there is a net closing force on the leaves. The seals were tested to 70 psi at speeds to 16,000 rpm or surface speeds to 330 fps and temperatures from ambient to 440 F. A slow cycle through the rig critical at 10,000 rpm induced a radial vibration response of 0.004 to 0.005 inch were accommodated by the seal. Preliminary performance data are encouraging demonstrating hydrodynamic liftoff and noncontacting operation at pressure and speeds typical of gas turbine engines. The leakage performance data are significantly better than commercial labyrinth and brush seals which should be expected as this design incorporates the features of the low leakage face or mechanical seal along with the flexibility of the brush configuration.

  15. Hypertensive Crisis From the Aquamantys Bipolar Sealing System.

    Science.gov (United States)

    Hardy, Brian C; Giordano, Christopher R

    2016-12-15

    Hypertension is a common occurrence during general anesthesia. Apart from pathological causes of hypertension, it is rarely extreme enough to be classified as a hypertensive crisis (systolic blood pressure >180 mm Hg or diastolic blood pressure >120 mm Hg). There is literature concerning the unintentional electrocauterization of the adrenal gland leading to hypertensive crisis, but to date, no reports have been made of adrenal stimulation from the use of an Aquamantys for hemostasis. Here, we report such a case when a hypertensive crisis (systolic blood pressure >300 mm Hg) occurred while using an Aquamantys during a liver transplant after unintentional stimulation of the adrenal glands.

  16. Genetics of bipolar disorder

    OpenAIRE

    Kerner, Berit

    2014-01-01

    Berit Kerner Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA Abstract: Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs) and bipolar ...

  17. Foil Face Seal Testing

    Science.gov (United States)

    Munson, John

    2009-01-01

    In the seal literature you can find many attempts by various researchers to adapt film riding seals to the gas turbine engine. None have been successful, potential distortion of the sealing faces is the primary reason. There is a film riding device that does accommodate distortion and is in service in aircraft applications, namely the foil bearing. More specifically a foil thrust bearing. These are not intended to be seals, and they do not accommodate large axial movement between shaft & static structure. By combining the 2 a unique type of face seal has been created. It functions like a normal face seal. The foil thrust bearing replaces the normal primary sealing surface. The compliance of the foil bearing allows the foils to track distortion of the mating seal ring. The foil seal has several perceived advantages over existing hydrodynamic designs, enumerated in the chart. Materials and design methodology needed for this application already exist. Also the load capacity requirements for the foil bearing are low since it only needs to support itself and overcome friction forces at the antirotation keys.

  18. Seal containment system

    International Nuclear Information System (INIS)

    Kugler, R.W.; Gerkey, K.S.; Kasner, W.H.

    1978-01-01

    An automated system for transporting nuclear fuel elements between fuel element assembly stations without contaminating the area outside the sealed assembly stations is described. The system comprises a plurality of assembly stations connected together by an elongated horizontal sealing mechanism and an automatic transport mechanism for transporting a nuclear fuel element in a horizontal attitude between the assembly stations while the open end of the fuel element extends through the sealing mechanism into the assembly station enclosure. The sealing mechanism allows the fuel element to be advanced by the transport mechanism while limiting the escape of radioactive particles from within the assembly station enclosure. 4 claims, 6 figures

  19. [Antidepressants in bipolar disorder].

    Science.gov (United States)

    Courtet, P; Samalin, L; Olié, E

    2011-12-01

    Whereas mania defines the bipolar disorder, depression is the major challenge of treatment. In general, depressions are more frequent, longer, with a major prognostic impact in terms of disability and suicide. How should we treat a patient with bipolar depression? Antidepressants are the treatment of choice for depression, but not in the bipolar disorder. In this context, we have traditionally accepted that antidepressants are effective but they were inducing a significant risk of destabilization of the bipolar disorder, because of the transitions to mania and rapid cycling. Current data reconsider both the two aspects of this risk-benefit ratio. The effectiveness of antidepressants finally seems very limited, especially after the more recent studies with a robust methodology. Manic switches and rapid cycling may not be increased, particularly with new antidepressants and mood stabilizer combinations. The current literature reminds us that these course's modalities are inherent to the disease, with numerous risk factors, and among them, exposure to antidepressants. Who are the bipolar patients who only get the benefits of antidepressant treatment? Research will tell. They are in any case limited. How to navigate in our treatment strategies ? By choosing first drugs that demonstrated efficacy in bipolar depression. When the situation is more complex, "primum non nocere" should lead to support the prescription of the antidepressant in association with mood stabilizer. Copyright © 2011 L’Encéphale. Published by Elsevier Masson SAS.. All rights reserved.

  20. High Test Peroxide High Sealing Conical Seal, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — High Test Peroxide (HTP) Highly Compatible High Sealing Conical Seals are necessary for ground test operations and space based applications. Current conical seals...

  1. Experimental toxoplasma gondii infection in grey seals (Halichoerus grypus)

    DEFF Research Database (Denmark)

    Gajadhar, A. A.; Measures, L.; Forbes, L. B.

    2004-01-01

    or muscle tissue collected from inoculated seals passed T. gondii oocysts in feces. This study demonstrates that T. gondii oocysts can establish viable infection in seals and supports the hypothesis that toxoplasmosis in marine mammals can be acquired from oocysts in surface water runoff and sewer discharge....

  2. Mercury and selenium in wild and experimental seals

    NARCIS (Netherlands)

    Ven, van de W.S.M.; Koeman, J.H.; Svenson, A.

    1979-01-01

    This paper describes the tissue distribution of inorganic mercury, organic mercury selenium in Dutch and British seals as well as in seals which were dosed with methylmercury under experimental conditions. In the experimental animals, a time-related increase of both mercury and selenium was found in

  3. Sealed radioactive sources toolkit

    International Nuclear Information System (INIS)

    Mac Kenzie, C.

    2005-09-01

    The IAEA has developed a Sealed Radioactive Sources Toolkit to provide information to key groups about the safety and security of sealed radioactive sources. The key groups addressed are officials in government agencies, medical users, industrial users and the scrap metal industry. The general public may also benefit from an understanding of the fundamentals of radiation safety

  4. Seals and Scrolls.

    Science.gov (United States)

    Macaulay, Sara Grove

    2000-01-01

    Describes an art unit in which students sculpt a signature seal out of clay and use Chinese brush painting techniques to paint a scroll. Discusses the seal and its historical use in China. Lists materials needed and explains the procedure. (CMK)

  5. Flexible Seal Accommodates Part Mismatch

    Science.gov (United States)

    Bobb, I.

    1983-01-01

    Chain of plates embedded in flexible seal enables it to withstand side loading of 2,300 psi (116MPa) while sealing gap of up to 0.5 inch (13 mm) between cylindrical chamber wall and test fixture. Pressure-actuated seal along inner edge forces seal into contact even though cylinder wall becomes eccentric as cylinder pressure increases. Seal has many industrial applications, particularly where heat or pressure causes distortion of chamber being sealed.

  6. Brush seal performance measurement system

    OpenAIRE

    Aksoy, Serdar; Akşit, Mahmut Faruk; Aksit, Mahmut Faruk; Duran, Ertuğrul Tolga; Duran, Ertugrul Tolga

    2009-01-01

    Brush seals are rapidly replacing conventional labyrinth seals in turbomachinery applications. Upon pressure application, seal stiffness increases drastically due to frictional bristle interlocking. Operating stiffness is critical to determine seal wear life. Typically, seal stiffness is measured by pressing a curved shoe to brush bore. The static-unpressurized measurement is extrapolated to pressurized and high speed operating conditions. This work presents a seal stiffness measurement syste...

  7. Reactor vessel sealing plug

    International Nuclear Information System (INIS)

    Dooley, R.A.

    1986-01-01

    An apparatus is described for sealing a cold leg nozzle of a nuclear reactor pressure vessel from a remote location comprising: at least one sealing plug for mechanically sealing the nozzle from the inside of the reactor pressure vessel. The sealing plug includes a plate and a cone assembly having an end part receptive in the nozzle, the plate being axially moveable relative to the cone assembly. The plate and cone assembly have confronting bevelled edges defining an opening therebetween. A primary O-ring is disposed about the opening and is supported on the bevelled edges, the plate being guidably mounted to the cone assembly for movement toward the cone assembly to radially expand the primary O-ring into sealing engagement with the nozzle. A means is included for providing relative movement between the outer plate and the cone assembly

  8. Depression and Bipolar Support Alliance

    Science.gov (United States)

    Depression and Bipolar Support Alliance Crisis Hotline Information Coping with a Crisis Suicide Prevention Information Psychiatric Hospitalization ... sign-up Education info, training, events Mood Disorders Depression Bipolar Disorder Anxiety Screening Center Co-occurring Illnesses/ ...

  9. Bipolar Affective Disorder and Migraine

    Directory of Open Access Journals (Sweden)

    Birk Engmann

    2012-01-01

    Full Text Available This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of comorbid migraine than bipolar I patients have. The literature on the common roots of migraine and bipolar disorder, including both genetic and neuropathological approaches, is broadly discussed. Moreover, bipolar disorder and migraine are often combined with a variety of other affective disorders, and, furthermore, behavioural factors also play a role in the origin and course of the diseases. Approach to treatment options is also difficult. Several papers point out possible remedies, for example, valproate, topiramate, which acts on both diseases, but no first-choice treatments have been agreed upon yet.

  10. Vacuum sealing and cooling as methods to preserve surgical specimens

    DEFF Research Database (Denmark)

    Kielsgaard Kristensen, Thomas; Engvad, Birte; Nielsen, Ole

    2011-01-01

    Recently, vacuum-based preservation of surgical specimens has been proposed as a safe alternative to formalin fixation at the surgical theater. The method seems feasible from a practical point of view, but no systematic study has examined the effect of vacuum sealing alone with respect to tissue...... preservation. In this study, we therefore subjected tissue samples from 5 different organs to treatments with and without vacuum sealing and cooling at 4°C to study the effect of vacuum sealing of surgical specimens with respect to tissue preservation and compare it with the effect of cooling. No preserving...... effect of vacuum sealing was observed with respect to cellular morphology, detection of immunohistochemical epitopes, or RNA integrity. In contrast, storage at 4°C was shown to preserve tissue to a higher degree than storage at room temperature for all included endpoints, independently of whether...

  11. Depressive and bipolar disorders

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Hansen, Hanne Vibe; Demyttenaere, Koen

    2005-01-01

    BACKGROUND: There is increasing evidence that attitudes and beliefs are important in predicting adherence to treatment and medication in depressive and bipolar disorders. However, these attitudes have received little study in patients whose disorders were sufficiently severe to require...... hospitalization. METHOD: The Antidepressant Compliance Questionnaire (ADCQ) was mailed to a large population of patients with depressive or bipolar disorder, representative of patients treated in hospital settings in Denmark. RESULTS: Of the 1005 recipients, 49.9% responded to the letter. A large proportion....... Moreover, their partners agreed on these negative views. Women had a more negative view of the doctor-patient relationship than men, and patients with a depressive disorder had a more negative view of antidepressants than patients with bipolar disorder. The number of psychiatric hospitalizations...

  12. SEALING SIMULATED LEAKS

    Energy Technology Data Exchange (ETDEWEB)

    Michael A. Romano

    2004-09-01

    This report details the testing equipment, procedures and results performed under Task 7.2 Sealing Simulated Leaks. In terms of our ability to seal leaks identified in the technical topical report, Analysis of Current Field Data, we were 100% successful. In regards to maintaining seal integrity after pigging operations we achieved varying degrees of success. Internal Corrosion defects proved to be the most resistant to the effects of pigging while External Corrosion proved to be the least resistant. Overall, with limitations, pressure activated sealant technology would be a viable option under the right circumstances.

  13. Computer modeling of electrical and thermal performance during bipolar pulsed radiofrequency for pain relief

    Energy Technology Data Exchange (ETDEWEB)

    Pérez, Juan J. [Instituto de Investigación Interuniversitario en Bioingeniería y Tecnología Orientada al Ser Humano, Universitat Politècnica de València, Valencia 46022 (Spain); Pérez-Cajaraville, Juan J. [Pain Unit and Department of Anesthesia and Critical Care, Clínica Universidad de Navarra, University of Navarra, Pamplona 31008 (Spain); Muñoz, Víctor [Neurotherm Spain, Barcelona 08303 (Spain); Berjano, Enrique, E-mail: eberjano@eln.upv.es [Biomedical Synergy, Electronic Engineering Department, Universitat Politècnica de València 46022 (Spain)

    2014-07-15

    Purpose: Pulsed RF (PRF) is a nonablative technique for treating neuropathic pain. Bipolar PRF application is currently aimed at creating a “strip lesion” to connect the electrode tips; however, the electrical and thermal performance during bipolar PRF is currently unknown. The objective of this paper was to study the temperature and electric field distributions during bipolar PRF. Methods: The authors developed computer models to study temperature and electric field distributions during bipolar PRF and to assess the possible ablative thermal effect caused by the accumulated temperature spikes, along with any possible electroporation effects caused by the electrical field. The authors also modeled the bipolar ablative mode, known as bipolar Continuous Radiofrequency (CRF), in order to compare both techniques. Results: There were important differences between CRF and PRF in terms of electrical and thermal performance. In bipolar CRF: (1) the initial temperature of the tissue impacts on temperature progress and hence on the thermal lesion dimension; and (2) at 37 °C, 6-min of bipolar CRF creates a strip thermal lesion between the electrodes when these are separated by a distance of up to 20 mm. In bipolar PRF: (1) an interelectrode distance shorter than 5 mm produces thermal damage (i.e., ablative effect) in the intervening tissue after 6 min of bipolar RF; and (2) the possible electroporation effect (electric fields higher than 150 kV m{sup −1}) would be exclusively circumscribed to a very small zone of tissue around the electrode tip. Conclusions: The results suggest that (1) the clinical parameters considered to be suitable for bipolar CRF should not necessarily be considered valid for bipolar PRF, and vice versa; and (2) the ablative effect of the CRF mode is mainly due to its much greater level of delivered energy than is the case in PRF, and therefore at same applied energy levels, CRF, and PRF are expected to result in same outcomes in terms of

  14. SRC seal testing

    Science.gov (United States)

    Miller, E. D.; Kohout, G. J.

    1973-01-01

    Small venthole drilled in semisealed silicon-controlled rectifier (SCR) cavity eliminates entrapped helium. Although these devices show slightly greater leak than those before lead installation, it is now possible to distinguish device with good hermetic seal from defective one.

  15. Turbine seal assembly

    Science.gov (United States)

    Little, David A.

    2013-04-16

    A seal assembly that limits gas leakage from a hot gas path to one or more disc cavities in a turbine engine. The seal assembly includes a seal apparatus that limits gas leakage from the hot gas path to a respective one of the disc cavities. The seal apparatus comprises a plurality of blade members rotatable with a blade structure. The blade members are associated with the blade structure and extend toward adjacent stationary components. Each blade member includes a leading edge and a trailing edge, the leading edge of each blade member being located circumferentially in front of the blade member's corresponding trailing edge in a direction of rotation of the turbine rotor. The blade members are arranged such that a space having a component in a circumferential direction is defined between adjacent circumferentially spaced blade members.

  16. [Sleep of Caspian seals].

    Science.gov (United States)

    Mukhametov, L M; Supin, A Ia; Poliakova, I G

    1984-01-01

    ECoG both hemispheres, EOG, neck EMG, ECG and electrical activity of olfactory bulbs were recorded in 4 free moving adult Caspean seals of both sexes. Their sleep on land and in water was compared. The wakefulness occupied 85,5 +/- 1,5% of total recording time, the slow wave sleep--12,8 +/- 1,4% and paradoxical sleep--1,7 +/- 0,2%. Unlike the dolphins, the Caspean seals possess no unihemispheric slow wave sleep. When the seals sleep on the land or on the water surface and do not change their posture for breathing they may breathe without awakening like the terrestrial mammals. But when the seals emerge or change their posture to get nostrils above the water they wake up briefly for respiration period.

  17. Core disruptive accident margin seal

    International Nuclear Information System (INIS)

    Golden, M.P.

    1979-01-01

    An apparatus for sealing the annulus defined within a substantially cylindrical rotatable riser assembly and plug combination of a nuclear reactor closure head is described. The apparatus comprises an inflatable sealing mechanism disposed in one portion of the riser assembly near the annulus such that upon inflation the sealing mechanism is radially actuated against the other portion of the riser assembly thereby sealing the annulus. The apparatus further comprises a connecting mechanism which places one end of the sealing mechanism in fluid communication with the reactor cover gas so that overpressurization of the reactor cover gas will increase the radial actuation of the sealing mechanism thus enhancing sealing of the annulus

  18. Ultra high vacuum seal arrangement

    Science.gov (United States)

    Flaherty, Robert

    1981-01-01

    Arrangement for demountably sealing two concentric metallic tubes in an ultra high vacuum system which facilitates remote actuation. A tubular seal includes integral spaced lips which circumferentially engage the metallic tubes. The lips plastically deform the metallic tubes by mechanical forces resulting from a martensite to austenite transformation of the tubular seal upon application of a predetermined temperature. The sealing force is released upon application of another temperature which causes a transformation from the stronger austenite to the weaker martensite. Use of a dual acting sealing ring and driving ring circumferentially contacting the sealing ring is particularly applicable to sealing larger diameter concentric metallic members.

  19. Titanium hermetic seals

    Science.gov (United States)

    Brow, Richard K.; Watkins, Randall D.

    1995-01-01

    Titanium is prenitrided by being heated in a nitrogen environment under conditions which give rise to the formation of a titanium-nitride surface layer on the titanium. Titanium thus prenitrided may be used in electrical components which are hermetically sealed using silicate glasses and standard glass sealing techniques. According to the method of the invention, alkali volatilization and formation of deleterious interfacial silicide are inhibited.

  20. Novel multiple criteria decision making methods based on bipolar neu trosophic sets and bipolar neutrosophic graphs

    OpenAIRE

    Muhammad Akram; Musavarah Sarwar

    2017-01-01

    In this research article, we present certain notions of bipolar neutrosophic graphs. We study the dominating and independent sets of bipolar neutrosophic graphs. We describe novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs.

  1. Discrete bipolar universal integrals

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.

    2014-01-01

    Roč. 252, č. 1 (2014), s. 55-65 ISSN 0165-0114 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : bipolar integral * universal integral * Choquet integral Subject RIV: BA - General Mathematics Impact factor: 1.986, year: 2014 http://library.utia.cas.cz/separaty/2014/E/mesiar-0432224.pdf

  2. [Spouses and bipolar disorder].

    Science.gov (United States)

    Ellouze, F; Ayedi, S; Cherif, W; Ben Abla, T; M'rad, M F

    2011-02-01

    To assess the quality of life of a population of spouses of bipolar patients compared with a control population. We conducted a cross-sectional study which included two groups: a group of 30 spouses of patients followed for bipolar I disorder according to DSM IV criteria and a second group of 30 subjects from the general population. Both groups were matched by age, sex, marital status and socioeconomic level. This device was designed to limit the differences between the two groups solely those of the bipolar illness. Evaluating the quality of life was achieved using the quality of life scale: SF-36. This is a scale that has already been translated and validated in dialect Arabic. Regarding sociodemographic variables, the two study groups differed only for: recreation, friendly relations and the couple relationship that included more and better skills among the control group. In the categorical approach, the quality of life was impaired in 60% of spouses and 40% of controls with a statistically significant difference. The following standardized dimensions: mental health (D4), limitation due to mental health (D5), life and relationship with others (D6) and perceived health (D8) and mental component (CM) were significantly altered in patients' spouses compared to controls. We found significant differences between the two groups for: overall average score (51.1 vs. 68.2), mental health (D4), limitation due to mental health (D5), life and relationship with others (D6), perceived health (D8) and perceived health (D8) standards. The impairment of quality of life of bipolar patients' spouses is related to the extra responsibility, stress, financial problems and health problems, stigma, and loss of security of the person loved. Considering the consequences that the appearance of bipolar disorder on the patient's spouse may have, certain measures must be proposed to improve their quality of life. Copyright © 2010 L'Encéphale, Paris. Published by Elsevier Masson SAS. All

  3. ON BIPOLAR SINGLE VALUED NEUTROSOPHIC GRAPHS

    OpenAIRE

    Broumi, Said; Talea, Mohamed; Bakali, Assia; Smarandache, Florentin

    2016-01-01

    In this article, we combine the concept of bipolar neutrosophic set and graph theory. We introduce the notions of bipolar single valued neutrosophic graphs, strong bipolar single valued neutrosophic graphs, complete bipolar single valued neutrosophic graphs, regular bipolar single valued neutrosophic graphs and investigate some of their related properties.

  4. Serum chemistry and antibodies against pathogens in antarctic fur seals, Weddell seals, crabeater seals, and Ross seals.

    Science.gov (United States)

    Tryland, Morten; Nymo, Ingebjørg H; Nielsen, Ole; Nordøy, Erling S; Kovacs, Kit M; Krafft, Bjørn A; Thoresen, Stein I; Åsbakk, Kjetil; Osterrieder, Klaus; Roth, Swaantje J; Lydersen, Christian; Godfroid, Jacques; Blix, Arnoldus S

    2012-07-01

    Information on health parameters, such as antibody prevalences and serum chemistry that can reveal exposure to pathogens, disease, and abnormal physiologic conditions, is scarce for Antarctic seal species. Serum samples from Antarctic fur seals (Arctocephalus gazella, n=88) from Bouvetøya (2000-2001 and 2001-2002), and from Weddell seals (Leptonychotes weddellii, n=20), Ross seals (Ommatophoca rossii, n=20), and crabeater seals (Lobodon carcinophagus, n=9) from the pack-ice off Queen Maud Land, Antarctica (2001) were analyzed for enzyme activity, and concentrations of protein, metabolites, minerals, and cortisol. Adult Antarctic fur seal males had elevated levels of total protein (range 64-99 g/l) compared to adult females and pups (range 52-79 g/l). Antarctic fur seals had higher enzyme activities of creatine kinase, lactate dehydrogenase, and amylase, compared to Weddell, Ross, and crabeater seals. Antibodies against Brucella spp. were detected in Weddell seals (37%), Ross seals (5%), and crabeater seals (11%), but not in Antarctic fur seals. Antibodies against phocine herpesvirus 1 were detected in all species examined (Antarctic fur seals, 58%; Weddell seals, 100%; Ross seals, 15%; and crabeater seals, 44%). No antibodies against Trichinella spp., Toxoplasma, or phocine distemper virus (PDV) were detected (Antarctic fur seals were not tested for PDV antibodies). Antarctic seals are challenged by reduced sea ice and increasing temperatures due to climate change, and increased anthropogenic activity can introduce new pathogens to these vulnerable ecosystems and represent a threat for these animals. Our data provide a baseline for future monitoring of health parameters of these Antarctic seal species, for tracking the impact of environmental, climatic, and anthropogenic changes in Antarctica over time.

  5. Early Intervention in Bipolar Disorder.

    Science.gov (United States)

    Vieta, Eduard; Salagre, Estela; Grande, Iria; Carvalho, André F; Fernandes, Brisa S; Berk, Michael; Birmaher, Boris; Tohen, Mauricio; Suppes, Trisha

    2018-01-24

    Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and usually has its onset during youth. Its chronic course is associated with high rates of morbidity and mortality, making bipolar disorder one of the main causes of disability among young and working-age people. The implementation of early intervention strategies may help to change the outcome of the illness and avert potentially irreversible harm to patients with bipolar disorder, as early phases may be more responsive to treatment and may need less aggressive therapies. Early intervention in bipolar disorder is gaining momentum. Current evidence emerging from longitudinal studies indicates that parental early-onset bipolar disorder is the most consistent risk factor for bipolar disorder. Longitudinal studies also indicate that a full-blown manic episode is often preceded by a variety of prodromal symptoms, particularly subsyndromal manic symptoms, therefore supporting the existence of an at-risk state in bipolar disorder that could be targeted through early intervention. There are also identifiable risk factors that influence the course of bipolar disorder, some of them potentially modifiable. Valid biomarkers or diagnosis tools to help clinicians identify individuals at high risk of conversion to bipolar disorder are still lacking, although there are some promising early results. Pending more solid evidence on the best treatment strategy in early phases of bipolar disorder, physicians should carefully weigh the risks and benefits of each intervention. Further studies will provide the evidence needed to finish shaping the concept of early intervention.

  6. Upgrading inflatable door seals

    International Nuclear Information System (INIS)

    Sykes, T.M.; Metcalfe, R.; Welch, L.A.; Josefowich, J.M.

    1997-01-01

    Inflatable door seals are used for airlocks in CANDU stations. They have been a significant source of unreliability and maintenance cost. A program is underway to improve their performance and reliability, backed by environmental qualification testing. Only commercial products and suppliers existed in 1993. For historical reasons, these 'existing products' did not use the most durable material then available. In hindsight, neither had they been adapted nor optimized to combat conditions often experienced in the plants-sagging doors, damaged sealing surfaces, and many thousands of openings and closings per year. Initial attempts to involve the two existing suppliers in efforts to upgrade these seals were unsuccessful. Another suitable supplier had therefore to be found, and a 'new,' COG-owned seal developed; this was completed in 1997. This paper summarizes its testing, along with that of the two existing products. Resistance to aging has been improved significantly. Testing has shown that an accident can be safely withstood after 10 years of service or 40,000 openings-closings, whichever comes first. AECL's Fluid Sealing Technology Unit (FSTU) has invested in the special moulds, test fixtures and other necessary tooling and documentation required to begin commercial manufacture of this new quality product. Accordingly, as with FSTU's other nuclear products such as pump seals, the long-term supply of door seals to CANDU plants is now protected from many external uncertainties-e.g., commercial products being discontinued, materials being changed, companies going out of business. Manufacturing to AECL's detailed specifications is being subcontracted to the new supplier. FSTU is performing the quality surveillance, inspection, testing, and customer service activities concomitant with direct responsibility for supply to the plants. (author)

  7. Laser Tissue Welding - Distal Pancreatectomy Sealing Study

    Science.gov (United States)

    2018-04-20

    Pancreatic Tumor, Benign; Pancreatic Neoplasms; Pancreatic Adenocarcinoma; Pancreatic Pseudocyst; Pancreatic Neuroendocrine Tumor; Pancreas; Insulinoma; Pancreatic Cyst; Pancreatic Teratoma; Pancreatic Polypeptide Tumor; Pancreatic Vipoma; Pancreatic Cystadenoma; Pancreas Injury; Pancreatic Gastrinoma; Pancreatic Glucagonoma

  8. Forged seal detection based on the seal overlay metric.

    Science.gov (United States)

    Lee, Joong; Kong, Seong G; Lee, Young-Soo; Moon, Ki-Woong; Jeon, Oc-Yeub; Han, Jong Hyun; Lee, Bong-Woo; Seo, Joong-Suk

    2012-01-10

    This paper describes a method for verifying the authenticity of a seal impression imprinted on a document based on the seal overlay metric, which refers to the ratio of an effective seal impression pattern and the noise in the neighborhood of the reference impression region. A reference seal pattern is obtained by taking the average of a number of high-quality impressions of a genuine seal. A target seal impression to be examined, often on paper with some background texts and lines, is segmented out from the background by an adaptive threshold applied to the histogram of color components. The segmented target seal impression is then spatially aligned with the reference by maximizing the count of matching pixels. Then the seal overlay metric is computed for the reference and the target. If the overlay metric of a target seal is below a predetermined limit for the similarity to the genuine, then the target is classified as a forged seal. To further reduce the misclassification rate, the seal overlay metric is adjusted by the filling rate, which reflects the quality of inked pattern of the target seal. Experiment results demonstrate that the proposed method can detect elaborate seal impressions created by advanced forgery techniques such as lithography and computer-aided manufacturing. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  9. Life expectancy in bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    OBJECTIVE: Life expectancy in patients with bipolar disorder has been reported to be decreased by 11 to 20 years. These calculations are based on data for individuals at the age of 15 years. However, this may be misleading for patients with bipolar disorder in general as most patients have a later...... onset of illness. The aim of the present study was to calculate the remaining life expectancy for patients of different ages with a diagnosis of bipolar disorder. METHODS: Using nationwide registers of all inpatient and outpatient contacts to all psychiatric hospitals in Denmark from 1970 to 2012 we...... remaining life expectancy in bipolar disorder and that of the general population decreased with age, indicating that patients with bipolar disorder start losing life-years during early and mid-adulthood. CONCLUSIONS: Life expectancy in bipolar disorder is decreased substantially, but less so than previously...

  10. Bipolar Disorder and Alcoholism: Are They Related?

    Science.gov (United States)

    ... Is there a connection between bipolar disorder and alcoholism? Answers from Daniel K. Hall-Flavin, M.D. Bipolar disorder and alcoholism often occur together. Although the association between bipolar ...

  11. Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder.

    Science.gov (United States)

    Dinsdale, Natalie L; Crespi, Bernard J

    2017-11-01

    Hippocrates attributed women's high emotionality - hysteria - to a 'wandering womb'. Although hysteria diagnoses were abandoned along with the notion that displaced wombs cause emotional disturbance, recent research suggests that elevated levels of oxytocin occur in both bipolar disorder and endometriosis, a gynecological condition involving migration of endometrial tissue beyond the uterus. We propose and evaluate the hypothesis that elevated oxytocinergic system activity jointly contributes to bipolar disorder and endometriosis. First, we provide relevant background on endometriosis and bipolar disorder, and then we examine evidence for comorbidity between these conditions. We next: (1) review oxytocin's associations with personality traits, especially extraversion and openness, and how they overlap with bipolar spectrum traits; (2) describe evidence for higher oxytocinergic activity in both endometriosis and bipolar disorder; (3) examine altered hypothalamic-pituitary-gonadal axis functioning in both conditions; (4) describe data showing that medications that treat one condition can improve symptoms of the other; (5) discuss fitness-related impacts of endometriosis and bipolar disorder; and (6) review a pair of conditions, polycystic ovary syndrome and autism, that show evidence of involving reduced oxytocinergic activity, in direct contrast to endometriosis and bipolar disorder. Considered together, the bipolar spectrum and endometriosis appear to involve dysregulated high extremes of normally adaptive pleiotropy in the female oxytocin system, whereby elevated levels of oxytocinergic activity coordinate outgoing sociality with heightened fertility, apparently characterizing, overall, a faster life history. These findings should prompt a re-examination of how mind-body interactions, and the pleiotropic endocrine systems that underlie them, contribute to health and disease. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Pool gateway seal

    International Nuclear Information System (INIS)

    Starr, J.A.; Steinert, L.A.

    1983-01-01

    A device for sealing a gateway between interconnectable pools in a nuclear facility comprising a frame supporting a liquid impermeable sheet positioned in a u-shaped gateway between the pools. An inflatable tube carried in a channel in the periphery of the frame and adjoining the gateway provides a seal therebetween when inflated. A restraining arrangement on the bottom edge of the frame is releasably engagable with an adjacent portion of the gateway to restrict the movement of the frame in the u-shaped gateway upon inflation of the tube, thereby enhancing the seal. The impermeable sheet is formed of an elastomer and thus is conformable to a liquid permeable supportive wall upon application of liquid pressure to the side of the sheet opposite the wall

  13. HMSRP Hawaiian Monk Seal Master Identification Records (seal)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains records of all individually identified Hawaiian monk seals since 1981. These seals were identified by PSD personnel and cooperating scientists...

  14. [Creativity and bipolar disorder].

    Science.gov (United States)

    Maçkalı, Zeynep; Gülöksüz, Sinan; Oral, Timuçin

    2014-01-01

    The relationship between creativity and bipolar disorder has been an intriguing topic since ancient times. Early studies focused on describing characteristics of creative people. From the last quarter of the twentieth century, researchers began to focus on the relationship between mood disorders and creativity. Initially, the studies were based on biographical texts and the obtained results indicated a relationship between these two concepts. The limitations of the retrospective studies led the researchers to develop systematic investigations into this area. The systematic studies that have focused on artistic creativity have examined both the prevalence of mood disorders and the creative process. In addition, a group of researchers addressed the relationship in terms of affective temperaments. Through the end of the 90's, the scope of creativity was widened and the notion of everyday creativity was proposed. The emergence of this notion led researchers to investigate the associations of the creative process in ordinary (non-artist) individuals. In this review, the descriptions of creativity and creative process are mentioned. Also, the creative process is addressed with regards to bipolar disorder. Then, the relationship between creativity and bipolar disorder are evaluated in terms of aforementioned studies (biographical, systematic, psychobiographical, affective temperaments). In addition, a new model, the "Shared Vulnerability Model" which was developed to explain the relationship between creativity and psychopathology is introduced. Finally, the methodological limitations and the suggestions for resolving these limitations are included.

  15. Bipolar Disorder and Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Sermin Kesebir

    2010-04-01

    Full Text Available Comorbid endocrine and cardiovascular situations with bipolar disorder usually result from the bipolar disorder itself or as a consequence of its treatment. With habits and lifestyle, genetic tendency and side effects, this situation is becoming more striking. Subpopulations of bipolar disorders patients should be considered at high risk for diabetes mellitus. The prevalence of diabetes mellitus in bipolar disorder may be three times greater than in the general population. Comorbidity of diabetes causes a pathophysiological overlapping in the neurobiological webs of bipolar cases. Signal mechanisms of glycocorticoid/insulin and immunoinflammatory effector systems are junction points that point out the pathophysiology between bipolar disorder and general medical cases susceptible to stress. Glycogen synthetase kinase (GSK-3 is a serine/treonine kinase and inhibits the transport of glucose stimulated by insulin. It is affected in diabetes, cancer, inflammation, Alzheimer disease and bipolar disorder. Hypoglycemic effect of lithium occurs via inhibiting glycogen synthetase kinase. When comorbid with diabetes, the other disease -for example bipolar disorder, especially during its acute manic episodes-, causes a serious situation that presents its influences for a lifetime. Choosing pharmacological treatment and treatment adherence are another important interrelated areas. The aim of this article is to discuss and review the etiological, clinical and therapeutic properties of diabetes mellitus and bipolar disorder comorbidity.

  16. Structural Design and Sealing Performance Analysis of Biomimetic Sealing Ring

    Directory of Open Access Journals (Sweden)

    Chuanjun Han

    2015-01-01

    Full Text Available In order to reduce the failure probability of rubber sealing rings in reciprocating dynamic seal, a new structure of sealing ring based on bionics was designed. The biomimetic ring has three concave ridges and convex bulges on each side which are very similar to earthworms. Bulges were circularly designed and sealing performances of the biomimetic ring in both static seal and dynamic seal were simulated by FEM. In addition, effects of precompression, medium pressure, speed, friction coefficient, and material parameters on sealing performances were discussed. The results show that von Mises stress of the biomimetic sealing ring distributed symmetrically in no-pressure static sealing. The maximum von Mises stress appears on the second bulge of the inner side. High contact stress concentrates on left bulges. Von Mises stress distribution becomes uneven under medium pressure. Both von Mises stress and contact stress increase when precompression, medium pressure, and rubber hardness increase in static sealing. Biomimetic ring can avoid rolling and distortion in reciprocating dynamic seal, and its working life is much longer than O-ring and rectangular ring. The maximum von Mises stress and contact stress increase with the precompression, medium pressure, rubber hardness, and friction coefficient in reciprocating dynamic seal.

  17. Blood temperature profiles of diving elephant seals.

    Science.gov (United States)

    Meir, Jessica U; Ponganis, Paul J

    2010-01-01

    Hypothermia-induced reductions in metabolic rate have been proposed to suppress metabolism and prolong the duration of aerobic metabolism during dives of marine mammals and birds. To determine whether core hypothermia might contribute to the repetitive long-duration dives of the northern elephant seal Mirounga angustirostris, blood temperature profiles were obtained in translocated juvenile elephant seals equipped with a thermistor and backpack recorder. Representative temperature (the y-intercept of the mean temperature vs. dive duration relationship) was 37.2 degrees C +/- 0.6 degrees C (n=3 seals) in the extradural vein, 38.1 degrees C +/- 0.7 degrees C (n = 4 seals) in the hepatic sinus, and 38.8 degrees +/- 1.6 degrees C (n = 6 deals) in the aorta. Mean temperature was significantly though weakly negatively related to dive duration in all but one seal. Mean venous temperatures of all dives of individual seals ranged between 36 degrees and 38 degrees C, while mean arterial temperatures ranged between 35 degrees and 39 degrees C. Transient decreases in venous and arterial temperatures to as low as 30 degrees -33 degrees C occurred in some dives >30 min (0.1% of dives in the study). The lack of significant core hypothermia during routine dives (10-30 min) and only a weak negative correlation of mean temperature with dive duration do not support the hypothesis that a cold-induced Q(10) effect contributes to metabolic suppression of central tissues during dives. The wide range of arterial temperatures while diving and the transient declines in temperature during long dives suggest that alterations in blood flow patterns and peripheral heat loss contribute to thermoregulation during diving.

  18. Static seal for turbine engine

    Science.gov (United States)

    Salazar, Santiago; Gisch, Andrew

    2014-04-01

    A seal structure for a gas turbine engine, the seal structure including first and second components located adjacent to each other and forming a barrier between high and low pressure zones. A seal cavity is defined in the first and second components, the seal cavity extending to either side of an elongated gap extending generally in a first direction between the first and second components. A seal member is positioned within the seal cavity and spans across the elongated gap. The seal member includes first and second side edges extending into each of the components in a second direction transverse to the first direction, and opposing longitudinal edges extending between the side edges generally parallel to the first direction. The side edges include a groove formed therein for effecting a reduction of gas flow around the seal member at the side edges.

  19. Magnetically Actuated Seal, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — FTT proposes development of a magnetically actuated dynamic seal. Dynamic seals are used throughout the turbopump in high-performance, pump-fed, liquid rocket...

  20. Magnetically Actuated Seal, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — FTT proposes development of a magnetically actuated dynamic seal. Dynamic seals are used throughout the turbopump in high-performance, pump-fed, liquid rocket...

  1. Continuous improvement of pump seals

    International Nuclear Information System (INIS)

    Wong, W.; Eyvindson, A.; Rhodes, D.B.

    2003-01-01

    Pump seal reliability continues to be an area needing improvement and ongoing vigilance. Methods have been developed for identifying and assessing factors relating to seal performance, selecting the most relevant ones for a specific station, and then focusing on the most significant aspects and how to improve. Discussion invariably addresses maintenance practices, seal design, monitoring capabilities, operating conditions, transients, and pump and motor design. Success in reliability improvement requires ongoing dialogue among the station operators, pump manufacturers and seal designers. AECL CAN-seals lead the nuclear industry in reliability and seal life. They effectively save operators millions of dollars in outage time and person-rem. This paper describes some of the significant developments in AECL's ongoing program in seal R and D, as well as recent new installations following the most demanding seal qualification programs to date. (author)

  2. GOLD PRESSURE VESSEL SEAL

    Science.gov (United States)

    Smith, A.E.

    1963-11-26

    An improved seal between the piston and die member of a piston-cylinder type pressure vessel is presented. A layer of gold, of sufficient thickness to provide an interference fit between the piston and die member, is plated on the contacting surface of at least one of the members. (AEC)

  3. Four Sided Seal Tester

    Science.gov (United States)

    2009-07-01

    The Center for Advanced Food Technology School of Enviromental and Biological Sciences New Brunswick, NJ 08903 FTR 216 Defense Logistics Agency...specification for four sided seal tester as function of confinement plate distance” The following modifications were issued :  Jul 18, 2007 0013/01

  4. Detection of grey seal

    NARCIS (Netherlands)

    van Bleijswijk, J.; Begeman, L.; Witte, H.J.; IJsseldijk, L.L.; Brasseur, S.M.J.M.; Gröne, A.; Leopold, M.F.

    2014-01-01

    DNA was analysed from external wounds on 3 dead harbour porpoises Phocoena phocoena that were stranded in the Netherlands. Puncture wounds as well as the edges of large open wounds were sampled with sterile cotton swabs. With specific primers that target the mtDNA control region of grey seal

  5. Ultrasonic dip seal maintenance system

    International Nuclear Information System (INIS)

    Poindexter, A.M.; Ricks, H.E.

    1978-01-01

    Disclosed is a system for removing impurities from the surfaces of liquid dip seals and for wetting the metal surfaces of liquid dip seals in nuclear components. The system comprises an ultrasonic transducer that transmits ultrasonic vibrations along an ultrasonic probe to the metal and liquid surfaces of the dip seal thereby loosening and removing those impurities

  6. Failure analysis and seal life prediction for contacting mechanical seals

    Science.gov (United States)

    Sun, J. J.; He, X. Y.; Wei, L.; Feng, X.

    2008-11-01

    Fault tree analysis method was applied to quantitatively investigate the causes of the leakage failure of mechanical seals. It is pointed out that the change of the surface topography is the main reasons causing the leakage of mechanical seals under the condition of constant preloads. Based on the fractal geometry theory, the relationship between the surface topography and working time were investigated by experiments, and the effects of unit load acting on seal face on leakage path in a mechanical seal were analyzed. The model of predicting seal life of mechanical seals was established on the basis of the relationship between the surface topography and working time and allowable leakage. The seal life of 108 mechanical seal operating at the system of diesel fuel storage and transportation was predicted and the problem of the condition monitoring for the long-period operation of mechanical seal was discussed by this method. The research results indicate that the method of predicting seal life of mechanical seals is feasible, and also is foundation to make scheduled maintenance time and to achieve safe-reliability and low-cost operation for industrial devices.

  7. The impact of bipolar depression.

    Science.gov (United States)

    Post, Robert M

    2005-01-01

    Bipolar disorder is a chronic, intermittent illness that is associated with high morbidity and mortality. In addition, patients with bipolar disorder often have comorbid psychiatric conditions (such as anxiety disorders, alcohol or substance abuse, and eating disorders) or medical disorders (such as obesity), which result in increased burden of illness for the patients, family members, and treating clinicians. Although bipolar disorder consists of recurring episodes of mania and depression, patients spend more time depressed than manic. Bipolar depression is associated with a greater risk of suicide and of impairment in work, social, or family life than mania. This health burden also results in direct and indirect economic costs to the individual and society at large. Bipolar depression is often undiagnosed or misdiagnosed as unipolar depression, resulting in incorrect or inadequate treatment. Available treatments for bipolar depression include medications such as lithium, selected anticonvulsants, and the atypical antipsychotics. Traditional antidepressants are not recommended as monotherapy for bipolar depression as they can induce switching to mania. Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder.

  8. Scientific attitudes towards bipolar disorders

    Directory of Open Access Journals (Sweden)

    Mohammad-Hossein Biglu

    2014-02-01

    Full Text Available Introduction: Bipolar disorder is a psychiatric condition that is also called manic-depressive disease. It causes unusual changes in mood, energy, activity levels, and the ability to carry out day-to-day tasks. In the present study, 3 sets of data were considered and analyzed: first, all papers categorized under Bipolar Disorders in Science Citation Index Expanded (SCI-E database through 2001-2011; second, papers published by the international journal of Bipolar Disorders indexed in SCI-E during a period of 11 years; and third, all papers distributed by the international journal of Bipolar Disorders indexed in MEDLINE during the period of study. Methods: The SCI-E database was used to extract all papers indexed with the topic of Bipolar Disorders as well as all papers published by The International Journal of Bipolar Disorders. Extraction of data from MEDLINE was restricted to the journals name from setting menu. The Science of Science Tool was used to map the co-authorship network of papers published by The International Journal of Bipolar Disorders through 2009-2011. Results: Analysis of data showed that the majority of publications in the subject area of bipolar disorders indexed in SCI-E were published by The International Journal of Bipolar Disorders. Although journal articles consisted of 59% of the total publication type in SCI-E, 65% of publications distributed by The Journal of Bipolar Disorders were in the form of meetingabstracts. Journal articles consisted of only 23% of the total publications. USA was the leading country regarding sharing data in the field of bipolar disorders followed by England, Canada, and Germany. Conclusion: The editorial policy of The International Journal of Bipolar Disorders has been focused on new themes and new ways of researching in the subject area of bipolar disorder. Regarding the selection of papers for indexing, the SCI-E database selects data more comprehensively than MEDLINE. The number of papers

  9. Genetics of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Kerner B

    2014-02-01

    Full Text Available Berit Kerner Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA Abstract: Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs and bipolar disorder. Currently, attempts are under way to translate these findings into clinical practice, genetic counseling, and predictive testing. However, some experts remain cautious. After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a “risk” allele are healthy. On the other hand, population-based genome-wide studies in psychiatric disorders have rediscovered rare structural variants and mutations in genes, which were previously known to cause genetic syndromes and monogenic Mendelian disorders. In many Mendelian syndromes, psychiatric symptoms are prevalent. Although these conditions do not fit the classic description of any specific psychiatric disorder, they often show nonspecific psychiatric symptoms that cross diagnostic boundaries, including intellectual disability, behavioral abnormalities, mood disorders, anxiety disorders, attention deficit, impulse control deficit, and psychosis. Although testing for chromosomal disorders and monogenic Mendelian disorders is well established, testing for common variants is still controversial. The standard concept of genetic testing includes at least three broad criteria that need to be fulfilled before new genetic tests should be introduced: analytical validity, clinical validity, and clinical utility. These criteria are

  10. Gulf and Dilmun Type seals

    DEFF Research Database (Denmark)

    Laursen, Steffen

    2011-01-01

    From around 2100 BC a glyptic tradition emerges in the Arabian Gulf, which is dependant on the well-established schools of the Indus Valley seal cutters. These circular hybrids of classic Harappan seals rapidly became popular amongst the merchants of Dilmun, centered on Bahrain Island. At first...... these Gulf Type‘ seals drew heavily on Indus Valley iconography and Indus script was occasionally employed in a pidgin-like manner. While the earliest circular seals incorporate features from Mesopotamian glyptic only to a lesser extent, this becomes a more important source of inspiration for later Dilmun...... Type seals....

  11. Novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs

    OpenAIRE

    Muhammad, Akram; Musavarah, Sarwar

    2016-01-01

    In this research study, we introduce the concept of bipolar neutrosophic graphs. We present the dominating and independent sets of bipolar neutrosophic graphs. We describe novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs. We also develop an algorithm for computing domination in bipolar neutrosophic graphs.

  12. Hermetic Seal Leak Detection Apparatus

    Science.gov (United States)

    Kelley, Anthony R. (Inventor)

    2013-01-01

    The present invention is a hermetic seal leak detection apparatus, which can be used to test for hermetic seal leaks in instruments and containers. A vacuum tight chamber is created around the unit being tested to minimize gas space outside of the hermetic seal. A vacuum inducing device is then used to increase the gas chamber volume inside the device, so that a slight vacuum is pulled on the unit being tested. The pressure in the unit being tested will stabilize. If the stabilized pressure reads close to a known good seal calibration, there is not a leak in the seal. If the stabilized pressure reads closer to a known bad seal calibration value, there is a leak in the seal. The speed of the plunger can be varied and by evaluating the resulting pressure change rates and final values, the leak rate/size can be accurately calculated.

  13. Seals Having Textured Portions for Protection in Space Environments

    Science.gov (United States)

    Daniels, Christopher (Inventor); Garafolo, Nicholas (Inventor)

    2016-01-01

    A sealing construct for a space environment includes a seal-bearing object, a seal on the seal-bearing object, and a seal-engaging object. The seal includes a seal body having a sealing surface, and a textured pattern at the sealing surface, the textured pattern defining at least one shaded channel surface. The seal-engaging object is selectively engaged with the seal-bearing object through the seal. The seal-engaging object has a sealing surface, wherein, when the seal-engaging object is selectively engaged with the seal-bearing object, the sealing surface of the seal-engaging object engages the sealing surface of the seal, and the seal is compressed between the seal-bearing object and the seal-engaging object such that at least one shaded channel surface engages the sealing surface of the seal-engaging object.

  14. Bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A.

    2008-10-21

    A bipolar pulse forming transmission line module for linear induction accelerators having first, second, third, fourth, and fifth planar conductors which form an interleaved stack with dielectric layers between the conductors. Each conductor has a first end, and a second end adjacent an acceleration axis. The first and second planar conductors are connected to each other at the second ends, the fourth and fifth planar conductors are connected to each other at the second ends, and the first and fifth planar conductors are connected to each other at the first ends via a shorting plate adjacent the first ends. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short a high voltage from the first end of the third planar conductor to the first end of the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  15. Radioactive waste sealing container

    International Nuclear Information System (INIS)

    Tozawa, S.; Kitamura, T.; Sugimoto, S.

    1984-01-01

    A low- to medium-level radioactive waste sealing container is constructed by depositing a foundation coating consisting essentially of zinc, cadmium or a zinc-aluminum alloy over a steel base, then coating an organic synthetic resin paint containing a metal phosphate over the foundation coating, and thereafter coating an acryl resin, epoxy resin, and/or polyurethane paint. The sealing container can consist of a main container body, a lid placed over the main body, and fixing members for clamping and fixing the lid to the main body. Each fixing member may consist of a material obtained by depositing a coating consisting essentially of cadmium or a zinc-aluminum alloy over a steel base

  16. Electromagnetic shaft seal

    International Nuclear Information System (INIS)

    Takahashi, Kenji.

    1994-01-01

    As an electromagnetic shaft seal, there are disposed outwarding electromagnetic induction devices having generating power directing to an electroconductive fluid as an object of sealing, and inwarding electromagnetic induction device added coaxially. There are disposed elongate rectangular looped first coils having a predetermined inner diameter, second coils having the same shape and shifted by a predetermined pitch relative to the first coil and third coil having the same shape and shifted by a predetermined pitch relative to the second coil respectively each at a predetermined inner diameter of clearance to the outwarding electromagnetic induction devices and the inwarding electromagnetic induction device. If the inwarding electromagnetic induction device and the outwarding electromagnetic induction device are operated, they are stopped at a point that the generating power of the former is equal with the sum of the generating power of the latter and a differential pressure. When three-phase AC is charged to the first coil, the second coil and the third coil successively, a force is generated in the advancing direction of the magnetic field in the electroconductive fluid by the similar effect to that of a linear motor, and the seal is maintained at high reliability. Moreover, the limit for the rotational angle of the shaft is not caused. (N.H.)

  17. Navy GTE seal development activity

    Science.gov (United States)

    Grala, Carl P.

    1993-10-01

    Under the auspices of the Integrated High Performance Turbine Engine Technology Initiative, the Naval Air Warfare Center conducts advanced development programs for demonstration in the next generation of air-breathing propulsion systems. Among the target technologies are gas path and lube oil seals. Two development efforts currently being managed by NAWCAD are the High Performance Compressor Discharge Film-Riding Face Seal and the Subsonic Core High Speed Air/Oil Seal. The High Performance Compressor Discharge Film-Riding Face Seal Program aims at reducing parasitic leakage through application of a film-riding face sea concept to the compressor discharge location of a Phase 2 IHPTET engine. An order-of-magnitude leakage reduction relative to current labyrinth seal configurations is expected. Performance goals for these seals are (1) 1200 F air temperature, (2) 800 feet-per-second surface velocity, and (3) 600 SPI differential pressure. The two designs chosen for fabrication and rig test are a spiral groove and a Rayleigh step seal. Rig testing is currently underway. The Subsonic Core High Speed Air/Oil Seal Program is developing shaft-to-ground seals for next-generation propulsion systems that will minimize leakage and provide full life. Significantly higher rotor speeds and temperatures will be experienced. Technologies being exploited include, hydrodynamic lift assist features, ultra light weight designs, and improved cooling schemes. Parametric testing has been completed; a final seal design is entering the endurance test phase.

  18. Closure and Sealing Design Calculation

    International Nuclear Information System (INIS)

    T. Lahnalampi; J. Case

    2005-01-01

    The purpose of the ''Closure and Sealing Design Calculation'' is to illustrate closure and sealing methods for sealing shafts, ramps, and identify boreholes that require sealing in order to limit the potential of water infiltration. In addition, this calculation will provide a description of the magma that can reduce the consequences of an igneous event intersecting the repository. This calculation will also include a listing of the project requirements related to closure and sealing. The scope of this calculation is to: summarize applicable project requirements and codes relating to backfilling nonemplacement openings, removal of uncommitted materials from the subsurface, installation of drip shields, and erecting monuments; compile an inventory of boreholes that are found in the area of the subsurface repository; describe the magma bulkhead feature and location; and include figures for the proposed shaft and ramp seals. The objective of this calculation is to: categorize the boreholes for sealing by depth and proximity to the subsurface repository; develop drawing figures which show the location and geometry for the magma bulkhead; include the shaft seal figures and a proposed construction sequence; and include the ramp seal figure and a proposed construction sequence. The intent of this closure and sealing calculation is to support the License Application by providing a description of the closure and sealing methods for the Safety Analysis Report. The closure and sealing calculation will also provide input for Post Closure Activities by describing the location of the magma bulkhead. This calculation is limited to describing the final configuration of the sealing and backfill systems for the underground area. The methods and procedures used to place the backfill and remove uncommitted materials (such as concrete) from the repository and detailed design of the magma bulkhead will be the subject of separate analyses or calculations. Post-closure monitoring will not

  19. TECHNOLOGY ROADMAPPING FOR IAEA SEALS.

    Energy Technology Data Exchange (ETDEWEB)

    HOFFHEINS,B.; ANNESE,C.; GOODMAN,M.; OCONNOR,W.; GUSHUE,S.; PEPPER,S.

    2003-07-13

    In the fall of 2002, the U.S. Support Program (USSP) initiated an effort to define a strategy or ''roadmap'' for future seals technologies and to develop a generalized process for planning safeguards equipment development, which includes seals and other safeguards equipment. The underlying objectives of the USSP include becoming more proactive than reactive in addressing safeguards equipment needs, helping the IAEA to maintain an inventory of cost-effective, reliable, and effective safeguards equipment, establishing a long-term planning horizon, and securing IAEA ownership in the process of effective requirements definition and timely transitioning of new or improved systems for IAEA use. At an initial workshop, seals, their functions, performance issues, and future embodiments were discussed in the following order: adhesive seals, metal seals, passive and active loop seals, ultrasonic seals, tamper indicating enclosures (including sample containers, equipment enclosures, and conduits). Suggested improvements to these technologies focused largely on a few themes: (1) The seals must be applied quickly, easily, and correctly; (2) Seals and their associated equipment should not unduly add bulk or weight to the inspectors load; (3) Rapid, in-situ verifiability of seals is desirable; and (4) Seal systems for high risk or high value applications should have two-way, remote communications. Based upon these observations and other insights, the participants constructed a skeletal approach for seals technology planning. The process begins with a top-level review of the fundamental safeguards requirements and extraction of required system features, which is followed by analysis of suitable technologies and identification of technology gaps, and finally by development of a planning schedule for system improvements and new technology integration. Development of a comprehensive procedure will require the partnership and participation of the IAEA. The

  20. TECHNOLOGY ROADMAPPING FOR IAEA SEALS

    International Nuclear Information System (INIS)

    HOFFHEINS, B.; ANNESE, C.; GOODMAN, M.; OCONNOR, W.; GUSHUE, S.; PEPPER, S.

    2003-01-01

    In the fall of 2002, the U.S. Support Program (USSP) initiated an effort to define a strategy or ''roadmap'' for future seals technologies and to develop a generalized process for planning safeguards equipment development, which includes seals and other safeguards equipment. The underlying objectives of the USSP include becoming more proactive than reactive in addressing safeguards equipment needs, helping the IAEA to maintain an inventory of cost-effective, reliable, and effective safeguards equipment, establishing a long-term planning horizon, and securing IAEA ownership in the process of effective requirements definition and timely transitioning of new or improved systems for IAEA use. At an initial workshop, seals, their functions, performance issues, and future embodiments were discussed in the following order: adhesive seals, metal seals, passive and active loop seals, ultrasonic seals, tamper indicating enclosures (including sample containers, equipment enclosures, and conduits). Suggested improvements to these technologies focused largely on a few themes: (1) The seals must be applied quickly, easily, and correctly; (2) Seals and their associated equipment should not unduly add bulk or weight to the inspectors' load; (3) Rapid, in-situ verifiability of seals is desirable; and (4) Seal systems for high risk or high value applications should have two-way, remote communications. Based upon these observations and other insights, the participants constructed a skeletal approach for seals technology planning. The process begins with a top-level review of the fundamental safeguards requirements and extraction of required system features, which is followed by analysis of suitable technologies and identification of technology gaps, and finally by development of a planning schedule for system improvements and new technology integration. Development of a comprehensive procedure will require the partnership and participation of the IAEA. The presentation will include a

  1. Asenapine for bipolar disorder

    Directory of Open Access Journals (Sweden)

    Scheidemantel T

    2015-12-01

    Full Text Available Thomas Scheidemantel,1 Irina Korobkova,2 Soham Rej,3,4 Martha Sajatovic1,2 1University Hospitals Case Medical Center, 2Case Western Reserve University School of Medicine, Cleveland, OH, USA; 3Department of Psychiatry, University of Toronto, Toronto, ON, 4Geri PARTy Research Group, Jewish General Hospital, Montreal, QC, Canada Abstract: Asenapine (Saphris® is an atypical antipsychotic drug which has been approved by the US Food and Drug Administration for the treatment of schizophrenia in adults, as well as the treatment of acute manic or mixed episodes of bipolar I in both adult and pediatric populations. Asenapine is a tetracyclic drug with antidopaminergic and antiserotonergic activity with a unique sublingual route of administration. In this review, we examine and summarize the available literature on the safety, efficacy, and tolerability of asenapine in the treatment of bipolar disorder (BD. Data from randomized, double-blind trials comparing asenapine to placebo or olanzapine in the treatment of acute manic or mixed episodes showed asenapine to be an effective monotherapy treatment in clinical settings; asenapine outperformed placebo and showed noninferior performance to olanzapine based on improvement in the Young Mania Rating Scale scores. There are limited data available on the use of asenapine in the treatment of depressive symptoms of BD, or in the maintenance phase of BD. The available data are inconclusive, suggesting the need for more robust data from prospective trials in these clinical domains. The most commonly reported adverse effect associated with use of asenapine is somnolence. However, the somnolence associated with asenapine use did not cause significant rates of discontinuation. While asenapine was associated with weight gain when compared to placebo, it appeared to be modest when compared to other atypical antipsychotics, and its propensity to cause increases in hemoglobin A1c or serum lipid levels appeared to be

  2. The influence of a gummy smile on lip seal.

    Science.gov (United States)

    dos Santos, Giselle Gasparino; Rego, Delane Maria

    2007-04-01

    The purpose of this study was to verify the influence of excessive gingival display on lip seal. Eighteen individuals with gummy smiles and poor lip seal were submitted to orofacial myofunctional assessment and surface electromyography in order to verify the action potential amplitude of mentalis muscle action generated during muscular exertion. Periodontal surgery was performed to remove excessive gingival tissue and bone volume from the pre-maxilla, and after 6 months, the patients were re-evaluated. Decreased contraction and tensing of the mentalis muscle (chin dimpling) was clinically observed when attempting lip seal and electromyographical analysis revealed a statistically significant difference among action potential values during muscular exertion to achieve lip contact. It was concluded that lip seal is influenced by gingival bone volume and that surgical removal contributed to a smoother contact between the lips.

  3. Ion bipolar junction transistors.

    Science.gov (United States)

    Tybrandt, Klas; Larsson, Karin C; Richter-Dahlfors, Agneta; Berggren, Magnus

    2010-06-01

    Dynamic control of chemical microenvironments is essential for continued development in numerous fields of life sciences. Such control could be achieved with active chemical circuits for delivery of ions and biomolecules. As the basis for such circuitry, we report a solid-state ion bipolar junction transistor (IBJT) based on conducting polymers and thin films of anion- and cation-selective membranes. The IBJT is the ionic analogue to the conventional semiconductor BJT and is manufactured using standard microfabrication techniques. Transistor characteristics along with a model describing the principle of operation, in which an anionic base current amplifies a cationic collector current, are presented. By employing the IBJT as a bioelectronic circuit element for delivery of the neurotransmitter acetylcholine, its efficacy in modulating neuronal cell signaling is demonstrated.

  4. Indirect bipolar electrodeposition.

    Science.gov (United States)

    Loget, Gabriel; Roche, Jérome; Gianessi, Eugenio; Bouffier, Laurent; Kuhn, Alexander

    2012-12-12

    Based on the principles of bipolar electrochemistry, localized pH gradients are generated at the surface of conducting particles in solution. This allows the toposelective deposition of inorganic and organic polymer layers via a pH-triggered precipitation mechanism. Due to the intrinsic symmetry breaking of the process, the concept can be used to generate in a straightforward way Janus particles, with one section consisting of deposits obtained from non-electroactive precursors. These indirect electrodeposits, such as SiO(2), TiO(2), or electrophoretic paints, can be further used as an immobilization matrix for other species like dyes or nanoparticles, thus opening promising perspectives for the synthesis of a variety of bifunctional objects with a controlled shape.

  5. Genetics of bipolar disorder.

    Science.gov (United States)

    Kerner, Berit

    2014-01-01

    Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs) and bipolar disorder. Currently, attempts are under way to translate these findings into clinical practice, genetic counseling, and predictive testing. However, some experts remain cautious. After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a "risk" allele are healthy. On the other hand, population-based genome-wide studies in psychiatric disorders have rediscovered rare structural variants and mutations in genes, which were previously known to cause genetic syndromes and monogenic Mendelian disorders. In many Mendelian syndromes, psychiatric symptoms are prevalent. Although these conditions do not fit the classic description of any specific psychiatric disorder, they often show nonspecific psychiatric symptoms that cross diagnostic boundaries, including intellectual disability, behavioral abnormalities, mood disorders, anxiety disorders, attention deficit, impulse control deficit, and psychosis. Although testing for chromosomal disorders and monogenic Mendelian disorders is well established, testing for common variants is still controversial. The standard concept of genetic testing includes at least three broad criteria that need to be fulfilled before new genetic tests should be introduced: analytical validity, clinical validity, and clinical utility. These criteria are currently not fulfilled for common genomic variants in psychiatric disorders. Further work is clearly needed before genetic testing for common variants in

  6. Giardia and Cryptosporidium in harp and hooded seals from the Gulf of St. Lawrence, Canada.

    Science.gov (United States)

    Appelbee, A J; Thompson, R C A; Measures, L M; Olson, M E

    2010-10-11

    Giardia and Cryptosporidium are protozoan parasites known to cause enteric disease in terrestrial wildlife species (mammals, reptiles and birds). Few surveys for Giardia and Cryptosporidium in marine wildlife species, such as pinnipeds, have been reported. The objective of this study was to determine the prevalence and genotype of Giardia and Cryptosporidium in two species of pinnipeds, harp seal (Phoca groenlandica) and hooded seal (Cystophora cristata), from the Gulf of St. Lawrence, Canada. Faecal samples were collected from pup and adult seals and examined for the presence of cysts of Giardia and oocysts of Cryptosporidium using microscopy and immunofluorescent staining. Tissues from the small intestine of adult seals were also collected and examined for infections using the polymerase chain reaction (PCR) technique. Giardia cysts were found in the faeces of 42% (16/38) of adult harp seals, but in none of the harp seal pups (0/20). Although Giardia cysts were not detected in faeces of adult hooded seals (0/10) using microscopy, 80% tested positive for Giardia using PCR of intestinal tissue indicative of a true replicating infection. Both harp and hooded seals harboured infections with the zoonotic strain, Giardia duodenalis Assemblage A, as determined using a nested-PCR technique to amplify a small subunit ribosomal (SSU-rRNA) gene of Giardia. Cryptosporidium was not detected by microscopy, nor using the PCR technique on intestinal tissues from any of the 68 seals examined. Copyright 2010 Elsevier B.V. All rights reserved.

  7. Modeling suicide in bipolar disorders.

    Science.gov (United States)

    Malhi, Gin S; Outhred, Tim; Das, Pritha; Morris, Grace; Hamilton, Amber; Mannie, Zola

    2018-02-19

    Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative that our current understanding be improved to facilitate prediction of suicide and its prevention. In this review, we provide a new perspective on the process of suicide in bipolar disorder, in the form of a novel integrated model that is derived from extant knowledge and recent evidence. A literature search of articles on suicide in bipolar disorder was conducted in recognized databases such as Scopus, PubMed, and PsycINFO using the keywords "suicide", "suicide in bipolar disorders", "suicide process", "suicide risk", "neurobiology of suicide" and "suicide models". Bibliographies of identified articles were further scrutinized for papers and book chapters of relevance. Risk factors for suicide in bipolar disorders are well described, and provide a basis for a framework of epigenetic mechanisms, moderated by neurobiological substrates, neurocognitive functioning, and social inferences within the environment. Relevant models and theories include the diathesis-stress model, the bipolar model of suicide and the ideation-to-action models, the interpersonal theory of suicide, the integrated motivational-volitional model, and the three-step theory. Together, these models provide a basis for the generation of an integrated model that illuminates the suicidal process, from ideation to action. Suicide is complex, and it is evident that a multidimensional and integrated approach is required to reduce its prevalence. The proposed model exposes and provides access to components of the suicide process that are potentially measurable and may serve as novel and specific therapeutic targets for interventions in the context of bipolar disorder. Thus, this model is useful not only

  8. Sealing of rock fractures

    International Nuclear Information System (INIS)

    Pusch, R.; Erlstroem, M.; Boergesson, L.

    1985-12-01

    The major water-bearing fractures in granite usually from fairly regular sets but the extension and degree of connectivity is varying. This means that only a few fractures that are interconnected with the deposition holes and larger water-bearing structures in a HLW repository are expected and if they can be identified and cut off through sealing it would be possible to improve the isolation of waste packages very effectively. Nature's own fracture sealing mechanisms may be simulated and a survey of the involved processes actually suggests a number of possible filling methods and substances. Most of them require high temperature and pressure and correspondingly sophisticated techniques, but some are of potential interest for immediate application with rather moderate effort. Such a technique is to fill the fractures with clayey substances which stay flexible and low-permeable provided that they remain physically and chemically intact. It is demonstrated in the report that effective grouting requires a very low viscosity and shear strength of the substance and this can be achieved by mechanical agitation as demonstrated in this report. Thus, by superimposing static pressure and shear waves induced by percussion hammering at a suitable frequency, clays and fine-grained silts as well as cement can be driven into fractures with an average aperture as small as 0.1 mm. Experiments were made in the laboratory using concrete and steel plates, and a field pilot test was also conducted under realistic conditions on site in Stripa. They all demonstrated the practicality of the 'dynamic injection technique' and that the fluid condition of the grouts yielded complete filling of the injected space to a considerable distance from the injection point. The field test indicated a good sealing ability as well as a surprisingly high resistance to erosion and piping. (author)

  9. Quetiapine monotherapy for bipolar depression

    Directory of Open Access Journals (Sweden)

    Michael E Thase

    2008-03-01

    Full Text Available Michael E ThaseDepartments of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; and the University of Pittsburgh Medical Center, Pittsburgh, PA, USAAbstract: Bipolar depression is more common, disabling, and difficult-to-treat than the manic and hypomanic phases that define bipolar disorder. Unlike the treatment of so-called “unipolar” depressions, antidepressants generally are not indicated as monotherapies for bipolar depressions and recent studies suggest that - even when used in combination with traditional mood stabilizers – antidepressants may have questionable value for bipolar depression. The current practice is that mood stabilizers are initiated first as monotherapies; however, the antidepressant efficacy of lithium and valproate is modest at best. Within this context the role of atypical antipsychotics is being evaluated. The combination of olanzapine and the antidepressant fluoxetine was the first treatment to receive regulatory approval in the US specifically for bipolar I depression. Quetiapine was the second medication to be approved for this indication, largely as the result of two pivotal trials known by the acronyms of BOLDER (BipOLar DEpRession I and II. Both studies demonstrated that two doses of quetiapine (300 mg and 600 mg given once daily at bedtime were significantly more effective than placebo, with no increased risk of patients switching into mania. Pooling the two studies, quetiapine was effective for both bipolar I and bipolar II depressions and for patients with (and without a history of rapid cycling. The two doses were comparably effective in both studies. Although the efficacy of quetiapine monotherapy has been established, much additional research is necessary. Further studies are needed to more fully investigate dose-response relationships and comparing quetiapine monotherapy to other mood stabilizers

  10. Non Destructive Seal Testing Polymeric Tray

    National Research Council Canada - National Science Library

    Bruins, Henderikus B

    2006-01-01

    .... The ND tester is based on a static compression force that reduces the volume of the tray and creates an internal pressure inside the tray and exposes the seal to forces that open the seal if the seal...

  11. One-piece modified gasket seal technique.

    Science.gov (United States)

    Wessell, Aaron; Singh, Ameet; Litvack, Zachary

    2013-10-01

    Objectives Review the effectiveness of a modified gasket seal technique utilizing a porous high-density polyethylene plate/rectus sheath fascia construct without fat grafting for primary closure of anterior defects following endoscopic skull base surgery. Design Retrospective review (2011-2012). Setting Single academic medical center. Methods A retrospective review of five patients who underwent expanded endoscopic endonasal surgery for various pathologies (two craniopharyngiomas, two tuberculum meningiomas, and one planum meningioma) was performed. Skull base closure was performed using a one-piece modified gasket seal technique. Primary outcome measures included postoperative cerebrospinal fluid (CSF) leaks and donor site morbidity. Results There were no postoperative CSF leaks. Two patients experienced aseptic meningitis treated with a 14-day course of steroids. Two patients experienced new postoperative chronic/recurrent sinusitis treated with oral antibiotics and topical nasal therapy. There was no donor site morbidity such as infection, hematoma, or hernias. Conclusions The one-piece modified gasket-seal closure is a safe and effective method for reconstruction of endonasal defects of the anterior skull base. Rectus sheath fascia is an appropriate dural substitute for free tissue grafting with low donor site morbidity. The construction of the one-piece graft significantly decreases operative time and lowers the learning curve for multilayered closure.

  12. Repository Closure and Sealing Approach

    International Nuclear Information System (INIS)

    A.T. Watkins

    2000-01-01

    The scope of this analysis will be to develop the conceptual design of the closure seals and their locations in the Subsurface Facilities. The design will be based on the recently established program requirements for transitioning to the Site Recommendation (SR) design as outlined by ''Approach to Implementing the Site Recommendation Baseline'' (Stroupe 2000) and the ''Monitored Geologic Repository Project Description Document'' (CRWMS M andO 1999b). The objective of this analysis will be to assist in providing a description for the Subsurface Facilities System Description Document, Section 2 and finally to document any conclusions reached in order to contribute and provide support to the SR. This analysis is at a conceptual level and is considered adequate to support the SR design. The final closure barriers and seals for the ventilation shafts, and the north and south ramps will require these openings to be permanently sealed to limit excessive air and water inflows and prevent human intrusion. The major tasks identified with closure in this analysis are: (1) Developing the overall subsurface seal layout and identifying design and operational interfaces for the Subsurface Facilities. (2) Summarizing the general site conditions and general rock characteristic with respect to seal location and describing the seal selected. (3) Identify seal construction materials, methodology of construction and strategic locations including design of the seal and plugs. (4) Discussing methods to prevent human intrusion

  13. High temperature autoclave vacuum seals

    Science.gov (United States)

    Hoffman, J. R.; Simpson, W. G.; Walker, H. M.

    1971-01-01

    Aluminum sheet forms effective sealing film at temperatures up to 728 K. Soft aluminum wire rings provide positive seal between foil and platen. For applications at temperatures above aluminum's service temperature, stainless steel is used as film material and copper wire as sealant.

  14. Cryogenic Pressure Seal for Wires

    Science.gov (United States)

    Ciana, J. J.

    1984-01-01

    High-pressure-seal formed by forcing polyurethane into space surrounding wire or cable in special fitting. Wire or cable routed through fitting then through a tightly fitting cap. Wire insulation left intact. Cap filled with sealant and forced onto the fitting: this pushes sealant into fitting so it seals wire or cable in fitting as well as in cap.

  15. Rotating plug bearing and seal

    International Nuclear Information System (INIS)

    Wade, E.E.

    1977-01-01

    Disclosed is a bearing and seal structure for nuclear reactors utilizing rotating plugs above the nuclear reactor vessel. The structure permits lubrication of bearings and seals of the rotating plugs without risk of the lubricant draining into the reactor vessel below. The structure permits lubrication by utilizing a rotating outer race bearing. 19 claims, 3 figures

  16. Seals. Grades 3-6.

    Science.gov (United States)

    New England Aquarium, Boston, MA.

    Explanations of a marine mammal rescue program and information on seals and sea lions are presented in this curriculum package for intermediate grade teachers. Activities are highlighted which focus on the natural history of harbor seals. This unit contains: (1) pre-trip activities (including fact sheets and worksheets on the different types of…

  17. Integrated neurobiology of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Vladimir eMaletic

    2014-08-01

    Full Text Available From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity—reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition—limits attempts to articulate an integrated perspective on bipolar disorder. However, despite these challenges, scientific findings in recent years are beginning to offer a provisional unified field theory of the disease. This theory sees bipolar disorder as a suite of related neurodevelopmental conditions with interconnected functional abnormalities that often appear early in life and worsen over time. In addition to accelerated loss of volume in brain areas known to be essential for mood regulation and cognitive function, consistent findings have emerged at a cellular level, providing evidence that bipolar disorder is reliably associated with dysregulation of glial-neuronal interactions. Among these glial elements are microglia—the brain’s primary immune elements, which appear to be overactive in the context of bipolarity. Multiple studies now indicate that inflammation is also increased in the periphery of the body in both the depressive and manic phases of the illness, with at least some return to normality in the euthymic state. These findings are consistent with changes in the HPA axis, which are known to drive inflammatory activation. In summary, the very fact that no single gene, pathway or brain abnormality is likely to ever account for the condition is itself an extremely important first step in better articulating an integrated perspective on both its ontological status and pathogenesis. Whether this perspective will translate into the discovery of innumerable more homogeneous forms of bipolarity is one of the great

  18. Modeling the thermal effect of the bipolar electrocautery for neurosurgery simulation.

    Science.gov (United States)

    Delorme, Sébastien; Cabral, Anne; Ayres, Fábio; Jiang, Di

    2011-01-01

    Real-time surgical simulation requires computationally-fast models describing the interaction between surgical instrument and tissues. In this study, a model for predicting the temperature distribution in brain tissue when using a bipolar electrocautery is proposed and validated against experimental in vitro animal data. Joule heat generation and heat conduction in the tissue are considered. The agreement between simulated temperature distributions and experimental data could be improved by modeling the output power as a function of electrical resistance between the electrodes, and by considering the heat exchange with surrounding air and bipolar tips.

  19. Aerodynamic seals for rotary machine

    Science.gov (United States)

    Bidkar, Rahul Anil; Cirri, Massimiliano; Thatte, Azam Mihir; Williams, John Robert

    2016-02-09

    An aerodynamic seal assembly for a rotary machine includes multiple sealing device segments disposed circumferentially intermediate to a stationary housing and a rotor. Each of the segments includes a shoe plate with a forward-shoe section and an aft-shoe section having multiple labyrinth teeth therebetween facing the rotor. The sealing device segment also includes multiple flexures connected to the shoe plate and to a top interface element, wherein the multiple flexures are configured to allow the high pressure fluid to occupy a forward cavity and the low pressure fluid to occupy an aft cavity. Further, the sealing device segments include a secondary seal attached to the top interface element at one first end and positioned about the flexures and the shoe plate at one second end.

  20. Turbine and Structural Seals Team Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — Seals Team Facilities conceive, develop, and test advanced turbine seal concepts to increase efficiency and durability of turbine engines. Current projects include...

  1. [Genetics of bipolar disorder].

    Science.gov (United States)

    Budde, M; Forstner, A J; Adorjan, K; Schaupp, S K; Nöthen, M M; Schulze, T G

    2017-07-01

    Bipolar disorder (BD) has a multifactorial etiology. Its development is influenced by genetic as well as environmental factors. Large genome-wide association studies (GWAS), in which genetic risk allelic variants for the disorder could be replicated for the first time, marked the breakthrough in the identification of the responsible risk genes. In addition to these common genetic variants with moderate effects identified by GWAS, rare variants with a higher penetrance are expected to play a role in disease development. The results of recent studies suggest that copy number variants might contribute to BD development, although to a lesser extent than in other psychiatric disorders, such as schizophrenia or autism. Results from the initial next generation sequencing studies indicate an enrichment of rare variants in pathways and genes that were previously found to be associated with BD. In the field of pharmacogenetics, a risk gene that influences the individual variance in the response to lithium treatment was identified for the first time in a recent large international GWAS. Currently the reported risk alleles do not sufficiently explain the phenotypic variance to be used for individual prediction of disease risk, disease course or response to medication. Future genetic research will provide important insights into the biological basis of BD by the identification of additional genes associated with BD. This knowledge of genetics will help identify potential etiological subgroups as well as cross-diagnostic disease mechanisms.

  2. Perfluorinated contaminants in fur seal pups and penguin eggs from South Shetland, Antarctica.

    Science.gov (United States)

    Schiavone, A; Corsolini, S; Kannan, K; Tao, L; Trivelpiece, W; Torres, D; Focardi, S

    2009-06-01

    Perfluorinated compounds (PFCs) have emerged as a new class of global environmental pollutants. In this study, the presence of perfluorochemicals (PFCs) in penguin eggs and Antarctic fur seals was reported for the first time. Tissue samples from Antarctic fur seal pups and penguin eggs were collected during the 2003/04 breeding season. Ten PFC contaminants were determined in seal and penguin samples. The PFC concentrations in seal liver were in the decreasing order, PFOS>PFNA>PFHpA>PFUnDA while in Adélie penguin eggs were PFHpA>PFUnDA>PFDA>PFDoDA, and in Gentoo penguin eggs were PFUnDA>PFOS>PFDoDA>PFHpA. The PFC concentrations differed significantly between seals and penguins (ppenguins (ppenguin eggs of 0.3 ng/g and 0.38 ng/g wet wt, respectively. PFCs detected in penguin eggs and seal pups suggested oviparous and viviparous transfer of PFOS to eggs and off-springs.

  3. Bipolar Disorder in Children and Teens

    Science.gov (United States)

    ... I do? Share Bipolar Disorder in Children and Teens Download PDF Download ePub Order a free hardcopy ... Think about death or suicide Can children and teens with bipolar disorder have other problems? Young people ...

  4. Tamper tape seals

    International Nuclear Information System (INIS)

    Wright, B.W.; Undem, H.A.

    1994-07-01

    Tamper tapes are appealing for many applications due to their ease of use and relative robustness. Applications include seals for temporary area denial, protection of sensitive equipment, chain-of-custody audit trails, and inventory control practices. A next generation of adhesive tamper tapes is being developed that combines the best features of commercially available devices with additional state-of-the-art features in tamper indication, tamper-resistance, and counterfeit-resistance. The additional features are based on U.S. Department of Energy (DOE) research and development (R ampersand D) activities that were originally associated with preparations for the Strategic Arms Reduction Treaty (START). New features include rapid-set, chemical-cure adhesive systems that allow user-friendly application and layered levels of counterfeit-resistance based on unique open-quotes fingerprintclose quotes characteristics that can be accessed as desired

  5. High pressure mechanical seal

    Science.gov (United States)

    Babel, Henry W. (Inventor); Anderson, Raymond H. (Inventor)

    1996-01-01

    A relatively impervious mechanical seal is formed between the outer surface of a tube and the inside surface of a mechanical fitting of a high pressure fluid or hydraulic system by applying a very thin soft metal layer onto the outer surface of the hard metal tube and/or inner surface of the hard metal fitting. The thickness of such thin metal layer is independent of the size of the tube and/or fittings. Many metals and alloys of those metals exhibit the requisite softness, including silver, gold, tin, platinum, indium, rhodium and cadmium. Suitably, the coating is about 0.0025 millimeters (0.10 mils) in thickness. After compression, the tube and fitting combination exhibits very low leak rates on the order or 10.sup.-8 cubic centimeters per second or less as measured using the Helium leak test.

  6. Molecular epidemiology of seal parvovirus, 1988-2014.

    Directory of Open Access Journals (Sweden)

    Rogier Bodewes

    Full Text Available A novel parvovirus was discovered recently in the brain of a harbor seal (Phoca vitulina with chronic meningo-encephalitis. Phylogenetic analysis of this virus indicated that it belongs to the genus Erythroparvovirus, to which also human parvovirus B19 belongs. In the present study, the prevalence, genetic diversity and clinical relevance of seal parvovirus (SePV infections was evaluated in both harbor and grey seals (Halichoerus grypus that lived in Northwestern European coastal waters from 1988 to 2014. To this end, serum and tissue samples collected from seals were tested for the presence of seal parvovirus DNA by real-time PCR and the sequences of the partial NS gene and the complete VP2 gene of positive samples were determined. Seal parvovirus DNA was detected in nine (8% of the spleen tissues tested and in one (0.5% of the serum samples tested, including samples collected from seals that died in 1988. Sequence analysis of the partial NS and complete VP2 genes of nine SePV revealed multiple sites with nucleotide substitutions but only one amino acid change in the VP2 gene. Estimated nucleotide substitution rates per year were 2.00 × 10(-4 for the partial NS gene and 1.15 × 10(-4 for the complete VP2 gene. Most samples containing SePV DNA were co-infected with phocine herpesvirus 1 or PDV, so no conclusions could be drawn about the clinical impact of SePV infection alone. The present study is one of the few in which the mutation rates of parvoviruses were evaluated over a period of more than 20 years, especially in a wildlife population, providing additional insights into the genetic diversity of parvoviruses.

  7. Molecular epidemiology of seal parvovirus, 1988-2014.

    Science.gov (United States)

    Bodewes, Rogier; Hapsari, Rebriarina; Rubio García, Ana; Sánchez Contreras, Guillermo J; van de Bildt, Marco W G; de Graaf, Miranda; Kuiken, Thijs; Osterhaus, Albert D M E

    2014-01-01

    A novel parvovirus was discovered recently in the brain of a harbor seal (Phoca vitulina) with chronic meningo-encephalitis. Phylogenetic analysis of this virus indicated that it belongs to the genus Erythroparvovirus, to which also human parvovirus B19 belongs. In the present study, the prevalence, genetic diversity and clinical relevance of seal parvovirus (SePV) infections was evaluated in both harbor and grey seals (Halichoerus grypus) that lived in Northwestern European coastal waters from 1988 to 2014. To this end, serum and tissue samples collected from seals were tested for the presence of seal parvovirus DNA by real-time PCR and the sequences of the partial NS gene and the complete VP2 gene of positive samples were determined. Seal parvovirus DNA was detected in nine (8%) of the spleen tissues tested and in one (0.5%) of the serum samples tested, including samples collected from seals that died in 1988. Sequence analysis of the partial NS and complete VP2 genes of nine SePV revealed multiple sites with nucleotide substitutions but only one amino acid change in the VP2 gene. Estimated nucleotide substitution rates per year were 2.00 × 10(-4) for the partial NS gene and 1.15 × 10(-4) for the complete VP2 gene. Most samples containing SePV DNA were co-infected with phocine herpesvirus 1 or PDV, so no conclusions could be drawn about the clinical impact of SePV infection alone. The present study is one of the few in which the mutation rates of parvoviruses were evaluated over a period of more than 20 years, especially in a wildlife population, providing additional insights into the genetic diversity of parvoviruses.

  8. Molecular Epidemiology of Seal Parvovirus, 1988–2014

    Science.gov (United States)

    Bodewes, Rogier; Hapsari, Rebriarina; Rubio García, Ana; Sánchez Contreras, Guillermo J.; van de Bildt, Marco W. G.; de Graaf, Miranda; Kuiken, Thijs; Osterhaus, Albert D. M. E.

    2014-01-01

    A novel parvovirus was discovered recently in the brain of a harbor seal (Phoca vitulina) with chronic meningo-encephalitis. Phylogenetic analysis of this virus indicated that it belongs to the genus Erythroparvovirus, to which also human parvovirus B19 belongs. In the present study, the prevalence, genetic diversity and clinical relevance of seal parvovirus (SePV) infections was evaluated in both harbor and grey seals (Halichoerus grypus) that lived in Northwestern European coastal waters from 1988 to 2014. To this end, serum and tissue samples collected from seals were tested for the presence of seal parvovirus DNA by real-time PCR and the sequences of the partial NS gene and the complete VP2 gene of positive samples were determined. Seal parvovirus DNA was detected in nine (8%) of the spleen tissues tested and in one (0.5%) of the serum samples tested, including samples collected from seals that died in 1988. Sequence analysis of the partial NS and complete VP2 genes of nine SePV revealed multiple sites with nucleotide substitutions but only one amino acid change in the VP2 gene. Estimated nucleotide substitution rates per year were 2.00×10−4 for the partial NS gene and 1.15×10−4 for the complete VP2 gene. Most samples containing SePV DNA were co-infected with phocine herpesvirus 1 or PDV, so no conclusions could be drawn about the clinical impact of SePV infection alone. The present study is one of the few in which the mutation rates of parvoviruses were evaluated over a period of more than 20 years, especially in a wildlife population, providing additional insights into the genetic diversity of parvoviruses. PMID:25390639

  9. Exercising control over bipolar disorder.

    Science.gov (United States)

    Malhi, Gin S; Byrow, Yulisha

    2016-11-01

    Following extensive research exercise has emerged as an effective treatment for major depressive disorder, and it is now a recognised therapy alongside other interventions. In contrast, there is a paucity of research examining the therapeutic effects of exercise for those with bipolar disorder. Given that dysfunctional reward processing is central to bipolar disorder, research suggests that exercise can perhaps be framed as a reward-related event that may have the potential to precipitate a manic episode. The behavioural activation system (BAS) is a neurobehavioural system that is associated with responding to reward and provides an appropriate framework to theoretically examine and better understand the effects of exercise treatment on bipolar disorder. This article discusses recent research findings and provides an overview of the extant literature related to the neurobiological underpinnings of BAS and exercise as they relate to bipolar disorder. This is important clinically because depending on mood state in bipolar disorder, we postulate that exercise could be either beneficial or deleterious with positive or negative effects on the illness. Clearly, this complicates the evaluation of exercise as a potential treatment in terms of identifying its optimal characteristics in this population. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. Comparison of two ultrasonic coagulating shears in sealing pulmonary vessels

    Directory of Open Access Journals (Sweden)

    Raghavan D

    2013-03-01

    Full Text Available Devanathan Raghavan,1 John A Howington,2 Duan Broughton,1 Cortney E Henderson,1 Jeffrey W Clymer1 1Preclinical Research, Ethicon Endo-Surgery, Cincinnati, OH, USA; 2NorthShore University HealthSystem, Chicago, IL, USA Abstract: Ultrasonic cutting and coagulating devices have been used successfully in thoracic applications such as pulmonary resection or artery harvesting, but few studies have evaluated their use in sealing pulmonary vessels. In this study we compared two commercially available devices, Harmonic Ace+ (HAR, Ethicon Endo-Surgery, Inc., Cincinnati OH, USA and SonoSurg (SS, Olympus America, Center Valley, PA, USA, in a canine preclinical model. There were three sections to the study: acute, survival, and ex vivo (burst pressure. Hemostasis of sealed pulmonary arteries and veins was assessed for the initial application and during a simulated hypertensive crisis, both immediately after vessel sealing and after a survival period of 30 days. Other intraoperative measures were also evaluated, including transection time, tissue sticking, tissue tags, and char on the seal. Histological evaluation was performed both after initial sealing and after the survival period. Burst pressure of sealed vessels was measured ex vivo. For both devices, hemostasis was excellent, including those measurements made under simulated hypertensive crisis. There were no differences in any of the intraoperative measures or thermal damage evaluated histologically. Wound healing was normal. The burst pressures for ex vivo vessels sealed by HAR (median 619.2 mmHg were significantly higher than those of SS (350.3 mmHg, P = 0.022. Both devices displayed acceptable characteristics in sealing canine pulmonary arteries and veins. The only difference observed was that HAR produced burst pressures 76.8% greater than SS, which may lead to a lower percentage of failures in the region of physiological interest. Use of ultrasonic devices in thoracic applications provides a high

  11. Imunologia do transtorno bipolar Immunology of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Izabela Guimarães Barbosa

    2009-01-01

    Full Text Available OBJETIVO: Pesquisas recentes têm implicado fatores imunes na patogênese de diversos transtornos neuropsiquiátricos. O objetivo do presente trabalho é revisar os trabalhos que investigaram a associação entre transtorno bipolar e alterações em parâmetros imunes. MÉTODOS: Artigos que incluíam as palavras-chave: "bipolar disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" e "tumor necrosis factor" foram selecionados em uma revisão sistemática da literatura. As bases de dados avaliadas foram MedLine e Scopus, entre os anos de 1980 e 2008. RESULTADOS: Foram identificados 28 trabalhos que estudaram alterações imunes em pacientes com transtorno bipolar. Seis artigos investigaram genes relacionados à resposta imune; cinco, autoanticorpos; quatro, populações leucocitárias; 13, citocinas e/ou moléculas relacionadas à resposta imune e seis, leucócitos de pacientes in vitro. CONCLUSÕES: Embora haja evidências na literatura correlacionando o transtorno bipolar a alterações imunes, os dados não são conclusivos. O transtorno bipolar parece estar associado a níveis mais elevados de autoanticorpos circulantes, assim como à tendência à ativação imune com produção de citocinas pró-inflamatórias e redução de parâmetros anti-inflamatórios.OBJECTIVE: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. METHODS: Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor necrosis factor" were selected in a systematic review of the literature. The evaluated databases were MedLine and Scopus in the period between 1980 and 2008. RESULTS: Twenty eight works were found. Six studies investigated immune response

  12. Rim seal arrangement having pumping feature

    Science.gov (United States)

    Lee, Ching-Pang; Myers, Caleb

    2017-04-25

    A rim seal arrangement for a gas turbine engine includes a first seal face on a rotor component, and a second seal face on a stationary annular rim centered about a rotation axis of the rotor component. The second seal face is spaced from the first seal face along an axial direction to define a seal gap. The seal gap is located between a radially outer hot gas path and a radially inner rotor cavity. The first seal face has a plurality of circumferentially spaced depressions, each having a depth in an axial direction and extending along a radial extent of the first seal face. The depressions influence flow in the seal gap such that during rotation of the rotor component, fluid in the seal gap is pumped in a radially outward direction to prevent ingestion of a gas path fluid from the hot gas path into the rotor cavity.

  13. Availability of prescription drugs for bipolar disorder at online pharmacies.

    Science.gov (United States)

    Monteith, Scott; Glenn, Tasha; Bauer, Rita; Conell, Jörn; Bauer, Michael

    2016-03-15

    There is increasing use of online pharmacies to purchase prescription drugs. While some online pharmacies are legitimate and safe, there are many unsafe and illegal so-called "rogue" online pharmacies. This study investigated the availability of psychotropic drugs online to consumers in the US, using 5 commonly prescribed drugs for bipolar disorder. Using the search term "buy [drug name]" in the Google, Yahoo and Bing search engines, the characteristics of the online pharmacies found on the first two pages of search results were investigated. The availability of the requested dosage and formulations of two brand (Seroquel XR, Abilify) and three generic drugs (lamotrigine, lithium carbonate and bupropion SR) were determined. Of 30 online pharmacies found, 17 (57%) were rated as rogue by LegitScript. Of the 30 pharmacies, 15 (50%) require a prescription, 21 (70%) claim to be from Canada, with 20 of these having a Canadian International Pharmacy association (CIPA) seal on the website. Only 13 of the 20 sites with a CIPA seal were active CIPA members. There were about the same number of trust verification seals on the rogue and legitimate pharmacy sites. Some rogue pharmacies are professional in appearance, and may be difficult for consumers to recognize as rogue. All five brand and generic drugs were offered for sale online, with or without a prescription. However, many substitutions were presented such as different strengths and formulations including products not approved by the FDA. No evaluation of product quality, packaging or purchasing. Psychotropic medications are available online with or without a prescription. The majority of online pharmacy websites were rogue. Physicians should ask about the use of online pharmacies. For those who choose to use online pharmacies, two measures to detect rogue pharmacies are recommended: (1) only purchase drugs from pharmacies that require a prescription, and (2) check all pharmacy verification seals directly on the website

  14. Mathematical models of bipolar disorder

    Science.gov (United States)

    Daugherty, Darryl; Roque-Urrea, Tairi; Urrea-Roque, John; Troyer, Jessica; Wirkus, Stephen; Porter, Mason A.

    2009-07-01

    We use limit cycle oscillators to model bipolar II disorder, which is characterized by alternating hypomanic and depressive episodes and afflicts about 1% of the United States adult population. We consider two non-linear oscillator models of a single bipolar patient. In both frameworks, we begin with an untreated individual and examine the mathematical effects and resulting biological consequences of treatment. We also briefly consider the dynamics of interacting bipolar II individuals using weakly-coupled, weakly-damped harmonic oscillators. We discuss how the proposed models can be used as a framework for refined models that incorporate additional biological data. We conclude with a discussion of possible generalizations of our work, as there are several biologically-motivated extensions that can be readily incorporated into the series of models presented here.

  15. Leak detection of KNI seals

    International Nuclear Information System (INIS)

    Baranyai, G.; Peter, A.; Windberg, P.

    1990-03-01

    In Unit 3 and 4 of the Paks Nuclear Power Plant, Hungary, KNI type seals are used as lead-throughs with conical nickel sealing rings. Their failure can be critical for the operation of the reactor. An Acoustical Leak Detection System (ALDS) was constructed and tested for the operational testing of the seals. Some individual papers are presented in this collection on the calibration and testing of the ALDS intended to be placed on the top of the reactor vessels. The papers include simulation measurements of Unit 3 of NPP, laboratory experiments, evaluation of measurements, and further development needs with the ALDS. (R.P.) 50 figs.; 19 tabs

  16. Transcultural aspects of bipolar disorder

    OpenAIRE

    Sanches, Marsal; Jorge, Miguel Roberto

    2004-01-01

    Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.Cultural variations in the expression of emotions have been described. Consequently, there are cross-cultural influences on the diagnosis and management o...

  17. Evaluation of a novel electrosurgical sealing mode in an ex vivo and in vivo porcine model.

    Science.gov (United States)

    Thiel, Karolin; Linzenbold, Walter; Enderle, Markus D; Nold, B; Königsrainer, Alfred; Schenk, Martin; Thiel, Christian

    2018-03-01

    Bipolar vessel sealing has been successfully introduced in a variety of procedures like prostatectomy, hysterectomy, and nephrectomy. In this study, we evaluated a new sealing mode-the thermoSEAL ® mode (TSM)-operated with the VIO3 generator in an ex vivo and in vivo animal study and compared the results with the commercially available BiClamp mode (BCM), operated with the VIO300D generator. Two different instruments were used in combination with both modes, BiCision ® and BiClamp ® 201T (Erbe Elektromedizin GmbH). In the ex vivo experiment, the sealing of renal arteries was evaluated using both instruments and modes. For the in vivo study, different types of arteries and veins were sealed using both modes and instruments in a side-by-side comparison for acute complications in a total of four animals. Mean burst pressure was in all cases significantly above 360 mmHg (p vivo setting was significantly shorter for TSM compared to BCM: BiCision ® (3.7 ± 0.4 vs. 7.1 ± 0.3 s; p vivo study was significantly shorter for TSM in combination with BiCision ® for arteries [TSM 3.0 ± 0.7 s vs. BCM 6.5 ± 1.3 s, (p 90%) were noted for both instruments and modes. While both modes used with two different instruments reveal high safety characterized by a high burst pressure, low thermal damage (ex vivo) zones, and high sealing rates (in vivo), the thermoSEAL ® mode convinces by its fast sealing speed probably helping to reduce operation time.

  18. Electronic monitoring in bipolar disorder.

    Science.gov (United States)

    Faurholt-Jepsen, Maria

    2018-03-01

    Major reasons for the insufficient effects of current treatment options in bipolar disorder include delayed intervention for prodromal depressive and manic symptoms and decreased adherence to psychopharmacological treatment. The reliance on subjective information and clinical evaluations when diagnosing and assessing the severity of depressive and manic symptoms calls for less biased and more objective markers. By using electronic devices, fine-grained data on complex psychopathological aspects of bipolar disorder can be evaluated unobtrusively over the long term. Moreover, electronic data could possibly represent candidate markers of diagnosis and illness activity in bipolar disorder and allow for early and individualized intervention for prodromal symptoms outside clinical settings. 
The present dissertation concerns the use of electronic monitoring as a marker and treatment intervention in bipolar disorder and investigated the scientific literature and body of evidence within the area, which includes ten original study reports and two systematic reviews, one of which included a meta-analysis, conducted by the author of the dissertation. 
Taken together, the literature presented in this dissertation illustrates that 1) smartphone-based electronic self-monitoring of mood seems to reflect clinically assessed depressive and manic symptoms and enables the long-term characterization of mood

instability in bipolar disorder; 2) preliminary results suggest that smartphone-based automatically generated data (e.g. the number of text messages sent/day; the number of incoming and outgoing calls/day; the number of changes in cell tower IDs/day; and voice features) seem to reflect clinically assessed depressive and manic symptoms in bipolar disorder; 3) smartphone-based electronic self-monitoring had no effects on the severity of depressive and manic symptoms in bipolar disorder, according to a randomized controlled trial; and 4) electronic monitoring of psychomotor

  19. 7 CFR 29.35 - Lot seal.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Lot seal. 29.35 Section 29.35 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.35 Lot seal. A seal approved by the Director for sealing lots of...

  20. 7 CFR 29.34 - Sample seal.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Sample seal. 29.34 Section 29.34 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.34 Sample seal. A seal approved by the Director for sealing official...

  1. Design considerations for mechanical face seals

    Science.gov (United States)

    Ludwig, L. P.; Greiner, H. F.

    1980-01-01

    Two companion reports deal with design considerations for improving performance of mechanical face seals, one of family of devices used in general area of fluid sealing of rotating shafts. One report deals with basic seal configuration and other with lubrication of seal.

  2. Epidemiologia do transtorno bipolar Epidemiology of bipolar disorders

    Directory of Open Access Journals (Sweden)

    Maurício Silva de Lima

    2005-01-01

    Full Text Available A formulação de políticas em saúde mental depende essencialmente de informações a respeito da freqüência e distribuição dos transtornos mentais. Nas últimas duas décadas, pesquisas de base populacional em epidemiologia psiquiátrica têm sido conduzidas, gerando informações detalhadas sobre freqüência, fatores de risco, incapacidade social e utilização de serviços de saúde. Neste artigo, dados sobre a epidemiologia do transtorno bipolar (TB são discutidos, a partir de resultados de recentes pesquisas populacionais: o estudo da Área de Captação Epidemiológica do Instituto Nacional de Saúde Mental dos Estados Unidos (ECA-NIMH, a Pesquisa Nacional de Comorbidade (NCS, a Pesquisa de Morbidade Psiquiátrica na Grã-Bretanha (OPCS, o Estudo Brasileiro Multicêntrico de Morbidade Psiquiátrica e os estudos longitudinais conduzidos por Angst, em Zurique. As estimativas de prevalências de transtorno bipolar são relativamente baixas, independentemente do lugar onde a pesquisa foi conduzida, do tipo de instrumento diagnóstico usado e dos períodos de tempo para os quais a prevalência se aplica. A partir da introdução do conceito de espectro bipolar, ampliando as fronteiras diagnósticas do TB, as estimativas de prevalências encontradas são substancialmente mais altas. Tais estimativas, entretanto, ainda carecem de validação em estudos populacionais. O transtorno afetivo bipolar é igualmente prevalente entre homens e mulheres, sendo mais freqüente entre solteiros ou separados. Indivíduos acometidos têm maiores taxas de desemprego e estão mais sujeitos a utilizarem serviços médicos e serem hospitalizados. O custo e a eficácia dos tratamentos do TB devem ser balanceados com o alto custo individual e social associados à enfermidade.Information about the epidemiology of bipolar disorders is essential for providing a framework for the formulation of effective mental health policy. In the last two decades, population

  3. Alaska Harbor Seal Glacial Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Floating glacial ice serves as a haul-out substrate for a significant number (10-15%) of Alaskan harbor seals, and thus surveying tidewater glacial fjords is an...

  4. Northern Fur Seal Food Habits

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains food habits samples, usually scats, collected opportunistically on northern fur seal rookeries and haulouts in Alaska from 1987 to present....

  5. M1 Abrams Seal Ring

    National Research Council Canada - National Science Library

    2004-01-01

    .... The 3.650-inch-diameter, 0.500-inch-wide seal, made of wrought A-286 nickel-iron super alloy, is difficult to clamp securely during machining, making it a challenge to maintain required roundness tolerances...

  6. Seals Research at AlliedSignal

    Science.gov (United States)

    Ullah, M. Rifat

    1996-01-01

    A consortium has been formed to address seal problems in the Aerospace sector of Allied Signal, Inc. The consortium is represented by makers of Propulsion Engines, Auxiliary Power Units, Gas Turbine Starters, etc. The goal is to improve Face Seal reliability, since Face Seals have become reliability drivers in many of our product lines. Several research programs are being implemented simultaneously this year. They include: Face Seal Modeling and Analysis Methodology; Oil Cooling of Seals; Seal Tracking Dynamics; Coking Formation & Prevention; and Seal Reliability Methods.

  7. Brush Seals for Improved Steam Turbine Performance

    Science.gov (United States)

    Turnquist, Norman; Chupp, Ray; Baily, Fred; Burnett, Mark; Rivas, Flor; Bowsher, Aaron; Crudgington, Peter

    2006-01-01

    GE Energy has retrofitted brush seals into more than 19 operating steam turbines. Brush seals offer superior leakage control compared to labyrinth seals, owing to their compliant nature and ability to maintain very tight clearances to the rotating shaft. Seal designs have been established for steam turbines ranging in size from 12 MW to over 1200 MW, including fossil, nuclear, combined-cycle and industrial applications. Steam turbines present unique design challenges that must be addressed to ensure that the potential performance benefits of brush seals are realized. Brush seals can have important effects on the overall turbine system that must be taken into account to assure reliable operation. Subscale rig tests are instrumental to understanding seal behavior under simulated steam-turbine operating conditions, prior to installing brush seals in the field. This presentation discusses the technical challenges of designing brush seals for steam turbines; subscale testing; performance benefits of brush seals; overall system effects; and field applications.

  8. Sealed can of spent fuel

    International Nuclear Information System (INIS)

    Suzuki, Yasuyuki.

    1976-01-01

    Object: To provide a seal plug cover with a gripping portion fitted to a canning machine and a gripping portion fitted to a gripper of the same configuration as a fuel body for handling the fuel body so as to facilitate the handling work. Structure: A sealed can comprises a vessel and a seal plug cover, said cover being substantially in the form of a bottomed cylinder, which is slipped on the vessel and air-tightly secured by a fastening bolt between it and a flange. The spent fuel body is received into the vessel together with coolant during the step of canning operation. Said seal plug cover has two gripping portions, one for opening and closing the plug cover of the canning machine as an exclusive use member, the other being in the form of a hook-shaped peripheral groove, whereby the gripping portions may be effectively used using the same gripper when the spent fuel body is transported while being received in the sealed can or when the fuel body is removed from the sealed can. (Kawakami, Y.)

  9. Reusable, tamper-indicating seal

    International Nuclear Information System (INIS)

    Ryan, M.J.

    1978-01-01

    A reusable, tamper-indicating seal is comprised of a drum confined within a fixed body and rotatable in one direction therewithin, the top of the drum constituting a tray carrying a large number of small balls of several different colors. The fixed body contains parallel holes for looping a seal wire therethrough. The base of the drums carries cams adapted to coact with cam followers to lock the wire within the seal at one angular position of the drum. A channel in the fixed body, visible from outside the seal, adjacent the tray constitutes a segregated location for a small plurality of the colored balls. A spring in the tray forces colored balls into the segregated location at one angular position of the drum, further rotation securing the balls in position and the wires in the seal. A wedge-shaped plough removes the balls from the segregated location, at a different angular position of the drum, the wire being unlocked at the same postion. A new pattern of colored balls will appear in the segregated location when the seal is relocked

  10. Mixed features in bipolar disorder.

    Science.gov (United States)

    Solé, Eva; Garriga, Marina; Valentí, Marc; Vieta, Eduard

    2017-04-01

    Mixed affective states, defined as the coexistence of depressive and manic symptoms, are complex presentations of manic-depressive illness that represent a challenge for clinicians at the levels of diagnosis, classification, and pharmacological treatment. The evidence shows that patients with bipolar disorder who have manic/hypomanic or depressive episodes with mixed features tend to have a more severe form of bipolar disorder along with a worse course of illness and higher rates of comorbid conditions than those with non-mixed presentations. In the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5), the definition of "mixed episode" has been removed, and subthreshold nonoverlapping symptoms of the opposite pole are captured using a "with mixed features" specifier applied to manic, hypomanic, and major depressive episodes. However, the list of symptoms proposed in the DSM-5 specifier has been widely criticized, because it includes typical manic symptoms (such as elevated mood and grandiosity) that are rare among patients with mixed depression, while excluding symptoms (such as irritability, psychomotor agitation, and distractibility) that are frequently reported in these patients. With the new classification, mixed depressive episodes are three times more common in bipolar II compared with unipolar depression, which partly contributes to the increased risk of suicide observed in bipolar depression compared to unipolar depression. Therefore, a specific diagnostic category would imply an increased diagnostic sensitivity, would help to foster early identification of symptoms and ensure specific treatment, as well as play a role in suicide prevention in this population.

  11. Exposure of harbour seals Phoca vitulina to Brucella in declining populations across Scotland.

    Science.gov (United States)

    Kershaw, Joanna L; Stubberfield, Emma J; Foster, Geoffrey; Brownlow, Andrew; Hall, Ailsa J; Perrett, Lorraine L

    2017-09-20

    Since 2000 there has been a major decline in the abundance of Scottish harbour seals Phoca vitulina. The causes of the decline remain uncertain. The aim of this study was to establish the extent to which the seals in the regions of greatest decline have been exposed to Brucella, a bacterial pathogen that causes reproductive failure in terrestrial mammalian hosts. Tissues from dead seals collected between 1992 and 2013 were cultured for Brucella (n = 150). Serum samples collected from live capture-released seals (n = 343) between 1997 and 2012 were tested for Brucella antibodies using the Rose Bengal plate agglutination test (RBT) and a competitive enzyme-linked immunosorbent assay (cELISA). In total, 16% of seals cultured had Brucella isolated from one or more tissues, but there were no pathological signs of infection. The cELISA results were more sensitive than the RBT results, showing that overall 25.4% of seals were seropositive, with the highest seroprevalence in juveniles. As there was no evidence of either a higher seroprevalence or higher circulating antibody levels in seropositive animals in the areas with the greatest declines, it was concluded that Brucella infection is likely not a major contributing factor to recent declines. However, the consistently high proportion of seals exposed to Brucella indicates possible endemicity in these populations, likely due to B. pinnipedialis, which has demonstrated a preference for pinniped hosts. Importantly, given the close proximity between seals, humans and livestock in many areas, there is the potential for cross-species infections.

  12. Integrated Neurobiology of Bipolar Disorder

    Science.gov (United States)

    Maletic, Vladimir; Raison, Charles

    2014-01-01

    From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity – reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition – limits attempts to articulate an integrated perspective on bipolar disorder. However, despite these challenges, scientific findings in recent years are beginning to offer a provisional “unified field theory” of the disease. This theory sees bipolar disorder as a suite of related neurodevelopmental conditions with interconnected functional abnormalities that often appear early in life and worsen over time. In addition to accelerated loss of volume in brain areas known to be essential for mood regulation and cognitive function, consistent findings have emerged at a cellular level, providing evidence that bipolar disorder is reliably associated with dysregulation of glial–neuronal interactions. Among these glial elements are microglia – the brain’s primary immune elements, which appear to be overactive in the context of bipolarity. Multiple studies now indicate that inflammation is also increased in the periphery of the body in both the depressive and manic phases of the illness, with at least some return to normality in the euthymic state. These findings are consistent with changes in the hypothalamic–pituitary–adrenal axis, which are known to drive inflammatory activation. In summary, the very fact that no single gene, pathway, or brain abnormality is likely to ever account for the condition is itself an extremely important first step in better articulating an integrated perspective on both its ontological status and pathogenesis. Whether this perspective will translate into the discovery of innumerable more homogeneous forms of

  13. Hydrodynamic perception in true seals (Phocidae) and eared seals (Otariidae).

    Science.gov (United States)

    Hanke, Wolf; Wieskotten, Sven; Marshall, Christopher; Dehnhardt, Guido

    2013-06-01

    Pinnipeds, that is true seals (Phocidae), eared seals (Otariidae), and walruses (Odobenidae), possess highly developed vibrissal systems for mechanoreception. They can use their vibrissae to detect and discriminate objects by direct touch. At least in Phocidae and Otariidae, the vibrissae can also be used to detect and analyse water movements. Here, we review what is known about this ability, known as hydrodynamic perception, in pinnipeds. Hydrodynamic perception in pinnipeds developed convergently to the hydrodynamic perception with the lateral line system in fish and the sensory hairs in crustaceans. So far two species of pinnipeds, the harbour seal (Phoca vitulina) representing the Phocidae and the California sea lion (Zalophus californianus) representing the Otariidae, have been studied for their ability to detect local water movements (dipole stimuli) and to follow hydrodynamic trails, that is the water movements left behind by objects that have passed by at an earlier point in time. Both species are highly sensitive to dipole stimuli and can follow hydrodynamic trails accurately. In the individuals tested, California sea lions were clearly more sensitive to dipole stimuli than harbour seals, and harbour seals showed a superior trail following ability as compared to California sea lions. Harbour seals have also been shown to derive additional information from hydrodynamic trails, such as motion direction, size and shape of the object that caused the trail (California sea lions have not yet been tested). The peculiar undulated shape of the harbour seals' vibrissae appears to play a crucial role in trail following, as it suppresses self-generated noise while the animal is swimming.

  14. Retroperitoneal Lumboaortic Lymphadenectomy Using a Vessel-Sealing Device in 10 Steps.

    Science.gov (United States)

    Schaub, Marie; Lecointre, Lise; Faller, Emilie; Boisramé, Thomas; Wattiez, Arnaud; Baldauf, Jean-Jacques; Akladios, Cherif

    2017-10-24

    Lumboaortic lymphadenectomy is frequently performed in the surgical management of different gynecologic pelvic malignancies: cervical endometrial and ovarian cancer. The retroperitoneal access presents a real advantage, allowing direct access to vascular axes, thus avoiding bowel segments. The use of a vessel-sealing device could facilitate the technique by providing an ergonomic alternative to conventional tools such as a bipolar grasper and scissors. Here the surgical technique of laparoscopic retroperitoneal lumboaortic lymphadenectomy using a vessel-sealing device in 10 steps is described. Educative video (Canadian Task Force classification III). Tertiary referral center in Strasbourg, France. Women undergoing lumboaortic lymphadenectomy. Laparoscopic retroperitoneal lumboaortic lymphadenectomy using a vessel-sealing device. The local institutional review board approved the video. The surgeon and assistant are positioned on the left of the patient and the column is placed in front. After peritoneal exploration 3 trocars are introduced in the left flank according to a very precise arrangement. We use a camera scope with a zero-degree view angle. After development of the extraperitoneal space and identification of the vascular landmarks, lymphadenectomy using a vessel-sealing device involves several steps in an anticlockwise direction starting from the left common iliac group. We first start with the lateroaortic group of lymph nodes. We then continue with the preaortic, interaorticocaval, and precaval supramesenteric group. After that, we perform the inframesenteric dissection of lymph nodes, the bifurcation of the aorta, and finally the right common iliac group. At the end of the procedure, in the absence of signs of metastatic lymph nodes, we open the peritoneum. Retroperitoneal lumboaortic lymphadenectomy using a vessel-sealing device is useful because of better ergonomics of the multitasking instrument, avoiding alternating between scissors and bipolar

  15. Development of borehole sealing technology

    International Nuclear Information System (INIS)

    Shimada, Kuniaki; Abe, Kenichi; Tanada, Masuakira; Fujii, Mitsuru

    2004-03-01

    As a part of the geoscientific research in JNC Tono Geoscience Center, we are conducting the borehole investigation as a method of surveying techniques to gain an understanding of geological environment characterization (geology/geological structure, rock hydraulic characteristics, ground water geochemical characteristics and rock mechanics) from surface to deep underground. The borehole for the borehole investigation is used for monitoring hole after the borehole investigation. Since the borehole may act as a passage of groundwater flow and disturb the geological environment artificially, it has to be sealed in finally. Moreover, the hydraulic testing and the geochemical analysis of groundwater that be conducted in the zones injected some kind of lost circulation materials might be impacted on the accuracy of test result. The actual technologies regarding to these themes was researched and evaluated. In the second step, clarification of problems and procedure of R and D for solution of these problems was examined. In order to estimate the effect of lost circulation materials on hydraulic testing, a laboratory test of borehole behavior was performed using a scale model that consisted of a borehole and a water-loss zone. In this test, we found out that the lost circulation material was desorbed from the water-loss zone by back-flow action. It was proved by the test that there is little influence from lost circulation materials on hydraulic testing. Investigation regarding borehole sealing technology was conducted in literature search and interview to overseas researchers. In consequent, three kinds of materials - bentonite clay, bentonite pellet, and ethanol bentonite, were selected as effective sealing material. Moreover, five kinds of methods were selected as effective sealing methods. In water permeability test of sealing material, three kinds of sealing materials indicated lower permeability - order of 10 -11 m/sec, and it was evaluated that it could be worked

  16. Spray sealing: A breakthrough in integral fuel tank sealing technology

    Science.gov (United States)

    Richardson, Martin D.; Zadarnowski, J. H.

    1989-11-01

    In a continuing effort to increase readiness, a new approach to sealing integral fuel tanks is being developed. The technique seals potential leak sources by spraying elastomeric materials inside the tank cavity. Laboratory evaluations project an increase in aircraft supportability and reliability, an improved maintainability, decreasing acquisition and life cycle costs. Increased usable fuel volume and lower weight than conventional bladders improve performance. Concept feasibility was demonstrated on sub-scale aircraft fuel tanks. Materials were selected by testing sprayable elastomers in a fuel tank environment. Chemical stability, mechanical properties, and dynamic durability of the elastomer are being evaluated at the laboratory level and in sub-scale and full scale aircraft component fatigue tests. The self sealing capability of sprayable materials is also under development. Ballistic tests show an improved aircraft survivability, due in part to the elastomer's mechanical properties and its ability to damp vibrations. New application equipment, system removal, and repair methods are being investigated.

  17. Harbour seals (Phoca vitulina and rehabilitation

    Directory of Open Access Journals (Sweden)

    Nynke Osinga

    2010-09-01

    Full Text Available Throughout the past few decades, rehabilitation of seals has become an activity that is anchored in the present day society of many countries. Seals are primarily rehabilitated to help individual animals in distress. At the same time, the release of seals which would have otherwise died can be considered as a contribution to the population. Most rehabilitated seals are animals under one year of age. They are mainly orphans, weaned seals with complications and seals with a parasiticbronchopneumonia. For the optimal handling of seals and their diseases, centralised operations with quality standards are essential. Rehabilitation provides an instrument to monitor the health of the seal population and its ecosystem. Changes in stranding trends or the appearance of new diseases can be monitored. Moreover, rehabilitation is important to show the general public thestate of the marine environment. In the Netherlands there is significant social support for the rehabilitation of seals. Experience obtained with seal care is of importance in countries where urgent help of threatened seal species is required. Here individual seals are also ambassadors to raise support for the protection of this species in general. Given that the anthropogenic impact on the seals and their environment is extensive in the Wadden Sea, rehabilitation centres can compensate the consequences of this impact on individual seals as well as the population as a whole.

  18. Turbine interstage seal with self-balancing capability

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Jacob A; Jones, Russell B; Sexton, Thomas D

    2017-09-26

    An interstage seal for a turbine of a gas turbine engine, the interstage seal having a seal carrier with an axial extending seal tooth movable with a stator of the engine, and a rotor with a seal surface that forms the interstage seal with the seal tooth, where a magnetic force produced by two magnets and a gas force produced by a gas pressure acting on the seal carrier forms a balancing force to maintain a close clearance of the seal without the seal tooth contacting the rotor seal surfaces during engine operation. In other embodiments, two pairs of magnets produce first and second magnetic forces that balance the seal in the engine.

  19. Bipolar polygenic loading and bipolar spectrum features in major depressive disorder

    NARCIS (Netherlands)

    Wiste, Anna; Robinson, Elise B.; Milaneschi, Yuri; Meier, Sandra; Ripke, Stephan; Clements, Caitlin C.; Fitzmaurice, Garrett M.; Rietschel, Marcella; Penninx, Brenda W.; Smoller, Jordan W.; Perlis, Roy H.

    Objectives Family and genetic studies indicate overlapping liability for major depressive disorder and bipolar disorder. The purpose of the present study was to determine whether this shared genetic liability influences clinical presentation. Methods A polygenic risk score for bipolar disorder,

  20. Monolithic LTCC seal frame and lid

    Energy Technology Data Exchange (ETDEWEB)

    Krueger, Daniel S.; Peterson, Kenneth A.; Stockdale, Dave; Duncan, James Brent; Riggs, Bristen

    2016-06-21

    A method for forming a monolithic seal frame and lid for use with a substrate and electronic circuitry comprises the steps of forming a mandrel from a ceramic and glass based material, forming a seal frame and lid block from a ceramic and glass based material, creating a seal frame and lid by forming a compartment and a plurality of sidewalls in the seal frame and lid block, placing the seal frame and lid on the mandrel such that the mandrel fits within the compartment, and cofiring the seal frame and lid block.

  1. EBR-II rotating plug seal maintenance

    International Nuclear Information System (INIS)

    Allen, K.J.

    1986-01-01

    The EBR-II rotating plug seals require frequent cleaning and maintenance to keep the plugs from sticking during fuel handling. Time consuming cleaning on the cover gas and air sides of the dip ring seal is required to remove oxidation and sodium reaction products that accumulate and stop plug rotation. Despite severely limited access, effective seal cleaning techniques have removed 11 800 lb (5 352 kg) of deposits from the seals since 1964. Temperature control modifications and repairs have also required major maintenance work. Suggested seal design recommendations could significantly reduce maintenance on future similar seals

  2. Unsplit bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A [Pleasanton, CA

    2011-05-24

    A bipolar pulse forming transmission line module and system for linear induction accelerators having first, second, third, and fourth planar conductors which form a sequentially arranged interleaved stack having opposing first and second ends, with dielectric layers between the conductors. The first and second planar conductors are connected to each other at the first end, and the first and fourth planar conductors are connected to each other at the second end via a shorting plate. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short at the first end a high voltage from the third planar conductor to the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  3. Mechanical seal with textured sidewall

    Energy Technology Data Exchange (ETDEWEB)

    Khonsari, Michael M.; Xiao, Nian

    2017-02-14

    The present invention discloses a mating ring, a primary ring, and associated mechanical seal having superior heat transfer and wear characteristics. According to an exemplary embodiment of the present invention, one or more dimples are formed onto the cylindrical outer surface of a mating ring sidewall and/or a primary ring sidewall. A stationary mating ring for a mechanical seal assembly is disclosed. Such a mating ring comprises an annular body having a central axis and a sealing face, wherein a plurality of dimples are formed into the outer circumferential surface of the annular body such that the exposed circumferential surface area of the annular body is increased. The texture added to the sidewall of the mating ring yields superior heat transfer and wear characteristics.

  4. Secondary seal effects in hydrostatic non-contact seals for reactor coolant pump shaft

    International Nuclear Information System (INIS)

    Fujita, T.; Koga, T.; Tanoue, H.; Hirabayashi, H.

    1987-01-01

    The paper presents a seal flow analysis in a hydrostatic non-contact seal for a PWR coolant pump shaft. A description is given of the non-contact seal for the reactor coolant pump. Results are presented for a distortion analysis of the seal ring, along with the seal flow characteristics and the contact pressure profiles of the secondary seals. The results of the work confirm previously reported findings that the seal ring distortion is sensitive to the o-ring location (which was placed between the ceramic seal face and the seal ring retainer). The paper concludes that the seal flow characteristics and the tracking performance depend upon the dynamic properties of the secondary seal. (U.K.)

  5. Course of Subthreshold Bipolar Disorder in Youth: Diagnostic Progression from Bipolar Disorder Not Otherwise Specified

    Science.gov (United States)

    Axelson, David A.; Birmaher, Boris; Strober, Michael A.; Goldstein, Benjamin I.; Ha, Wonho; Gill, Mary Kay; Goldstein, Tina R.; Yen, Shirley; Hower, Heather; Hunt, Jeffrey I.; Liao, Fangzi; Iyengar, Satish; Dickstein, Daniel; Kim, Eunice; Ryan, Neal D.; Frankel, Erica; Keller, Martin B.

    2011-01-01

    Objective: To determine the rate of diagnostic conversion from an operationalized diagnosis of bipolar disorder not otherwise specified (BP-NOS) to bipolar I disorder (BP-I) or bipolar II disorder (BP-II) in youth over prospective follow-up and to identify factors associated with conversion. Method: Subjects were 140 children and adolescents…

  6. Sealed source peer review plan

    International Nuclear Information System (INIS)

    Feldman, Alexander; Leonard, Lee; Burns, Ron

    2009-01-01

    Sealed sources are known quantities of radioactive materials that have been encapsulated in quantities that produce known radiation fields. Sealed sources have multiple uses ranging from instrument calibration sources to sources that produce radiation fields for experimental applications. The Off-Site Source Recovery (OSR) Project at Los Alamos National Laboratory (LANL), created in 1999, under the direction of the Waste Management Division of the U.S. Department of Energy (DOE) Albuquerque has been assigned the responsibility to recover and manage excess and unwanted radioactive sealed sources from the public and private sector. LANL intends to ship drums containing qualified sealed sources to the Waste Isolation Pilot Plant (WIPP) for disposal. Prior to shipping, these drums must be characterized with respect to radiological content and other parameters. The U. S. Environmental Protection Agency (EPA) requires that ten radionulcides be quantified and reported for every container of waste to be disposed in the WIPP. The methods traditionally approved by the EPA include non-destructive assay (NDA) in accordance with Appendix A of the Contact-Handled Transuranic Waste Acceptance Criteria for the Waste Isolation Pilot Plant (DOE, 2002) (CH WAC). However, because of the nature and pedigree of historical records for sealed sources and the technical infeasibility of performing NDA on these sources, LANL proposes to characterize the content of these waste drums using qualified existing radiological data in lieu of direct measurement. This plan describes the process and documentation requirements for the use of the peer review process to qualify existing data for sealed radiological sources in lieu of perfonning radioassay. The peer review process will be performed in accordance with criteria provided in 40 CFR (section) 194.22 which specifies the use of the NUREG 1297 guidelines. The plan defines the management approach, resources, schedule, and technical requirements

  7. Bipolar (spectrum) disorder and mood stabilization: standing at the crossroads?

    OpenAIRE

    De Fruyt, Jurgen; Demyttenaere, Koen

    2007-01-01

    Diagnosis and treatment of bipolar disorder has long been a neglected discipline. Recent years have shown an upsurge in bipolar research. When compared to major depressive disorder, bipolar research still remains limited and more expert based than evidence based. In bipolar diagnosis the focus is shifting from classic mania to bipolar depression and hypomania. There is a search for bipolar signatures in symptoms and course of major depressive episodes. The criteria for hypomania are softened,...

  8. Stabilizing geometry for hydrodynamic rotary seals

    Science.gov (United States)

    Dietle, Lannie L.; Schroeder, John E.

    2010-08-10

    A hydrodynamic sealing assembly including a first component having first and second walls and a peripheral wall defining a seal groove, a second component having a rotatable surface relative to said first component, and a hydrodynamic seal comprising a seal body of generally ring-shaped configuration having a circumference. The seal body includes hydrodynamic and static sealing lips each having a cross-sectional area that substantially vary in time with each other about the circumference. In an uninstalled condition, the seal body has a length defined between first and second seal body ends which varies in time with the hydrodynamic sealing lip cross-sectional area. The first and second ends generally face the first and second walls, respectively. In the uninstalled condition, the first end is angulated relative to the first wall and the second end is angulated relative to the second wall. The seal body has a twist-limiting surface adjacent the static sealing lip. In the uninstalled condition, the twist-limiting surface is angulated relative to the peripheral wall and varies along the circumference. A seal body discontinuity and a first component discontinuity mate to prevent rotation of the seal body relative to the first component.

  9. [Bipolar disorders in DSM-5].

    Science.gov (United States)

    Severus, E; Bauer, M

    2014-05-01

    In spring 2013 the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) edited by the American Psychiatric Association was published. The DSM-5 has also brought some important changes regarding bipolar disorders. The goal of this manuscript is to review the novelties in DSM-5 and to evaluate the implications of these changes. The diagnostic criteria as well as the additional remarks provided in the running text of DSM-5 were carefully appraised. For the first time diagnostic criteria are provided for disorders which up to now have been considered as subthreshold bipolar disorders. Furthermore, mixed episodes were eliminated and instead a mixed specifier was introduced. An increase in goal-directed activity/energy is now one of the obligatory symptoms for a (hypo)manic episode. Diagnostic guidance is provided as to when a (hypo)manic episode that has developed during treatment with an antidepressant has to be judged to be causally related to antidepressants and when this episode has only occurred coincidentally with antidepressant use. While some of the novelties are clearly useful, e.g. addition of increased goal-directed activity/energy as obligatory symptom for (hypo)manic episodes, this remains to be demonstrated for others, such as the definition of various subthreshold bipolar disorders.

  10. Self-Sealing Cryogenic Fitting

    Science.gov (United States)

    Jia, Lin Xiang; Chow, Wen Lung; Moslemian, Davood; Lin, Gary; Melton, Greg

    1994-01-01

    Self-sealing fitting for cryogenic tubes remains free of leakage from room temperature to liquid-helium temperature even at internal pressure as high as 2.7 MPa. Fitting comprises parts made of materials with different coefficients of thermal expansion to prevent leakage gaps from forming as temperature decreases. Consists of coupling nut, two flared tube ends, and flared O-ring spacer. Spacer contracts more than tube ends do as temperature decreases. This greater contraction seals tube ends more tightly, preventing leakage.

  11. Bipolar Disorder and Obsessive Compulsive Disorder Comorbidity

    Directory of Open Access Journals (Sweden)

    Necla Keskin

    2014-08-01

    Full Text Available The comorbidity of bipolar disorder and anxiety disorders is a well known concept. Obsessive-compulsive disorder is the most commonly seen comorbid anxiety disorder in bipolar patients. Some genetic variants, neurotransmitters especially serotonergic systems and second-messenger systems are thought to be responsible for its etiology. Bipolar disorder alters the clinical aspects of obsessive compulsive disorder and is associated with poorer outcome. The determination of comorbidity between bipolar disorder and obsessive compulsive disorder is quite important for appropriate clinical management and treatment. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(4.000: 429-437

  12. Seals in motion. How movements drive population development of harbour seals and grey seals in the North Sea

    OpenAIRE

    Brasseur, S.M.J.M.

    2017-01-01

    The harbour seal Phoca vitulina and the grey seal Halichoerus grypus have been inhabitants of the Wadden Sea since millennia. Prehistoric findings indicate the presence of both species around 5000 BC. This changed dramatically in the mid Middle-Ages as around 1500 AC, the grey seal disappeared from the Wadden Sea as a consequence of persecution. With growing hunting pressure, especially in the 20th century and concurrent habitat destruction and pollution, the harbour seals reached all time lo...

  13. Apollo Seals: A Basis for the Crew Exploration Vehicle Seals

    Science.gov (United States)

    Finkbeiner, Joshua R.; Dunlap, Patrick H., Jr.; Steinetz, Bruce M.; Daniels, Christopher C.

    2007-01-01

    NASA s Vision for Space Exploration Replace the Space Shuttle for missions to ISS. Return to the Moon. Allow manned exploration of Mars. Apollo-like configuration. Blunt-body heat shield. Conical backshell. CEV requires seal development. Prevent ingestion of reentry gases. Prevent loss of habitable atmosphere.

  14. Sealed osteons in animals and humans: low prevalence and lack of relationship with age.

    Science.gov (United States)

    Skedros, John G; Henrie, Tanner R; Doutré, Madison S; Bloebaum, Roy D

    2018-05-01

    Sealed osteons are unusual variants of secondary osteons that have received little attention, especially in non-human bones. Sealed osteons are characterized by central canals that are plugged with bone tissue. As with other variants of secondary osteons (e.g. drifting, dumbbell, multi-canal), understanding how and why sealed osteons form can shed light on the mechanisms that regulate normal bone remodeling and how this process can be perturbed with aging and some diseases. In a recent microscopic evaluation of human tibiae obtained after traumatic amputations, 4-5% of the osteons were sealed. It is suggested that this high prevalence reflects occasional localized microscopic ischemia from normal osteonal remodeling; hence sealed osteons are implicated in human skeletal fragility. Therefore, osteon prevalence would be expected to correlate with the bone remodeling seen with aging; for example, showing positive relationships between sealed osteons and the population density of typical secondary osteons (OPD). We evaluated the prevalence of partially sealed (80-99% sealed) and fully sealed osteons with respect to age and variations in OPD in 10 adult human femora (34-71 years) and in various non-human appendicular bones of mature animals that were not of advanced age, including deer calcanei, equine radii and equine third metacarpals. An additional sample of 10 bilateral human femora with unilateral non-cemented total hip replacements (F,+HR) and non-implanted contralateral femora (F,-HR) were evaluated (10 patients; 52-94 years). In non-human bones, sealed + partially sealed osteons were rare (~0.1%) even when having relatively high OPD. When considering sealed + partially sealed osteons in femora from patients without any HR, results showed that 1.6% of the osteons were sealed or partially sealed, which was much lower than anticipated, but this is 10- to 20-fold more than in any of the non-human bones. Additionally, in all bones, sealed + partially sealed

  15. Novel B19-like parvovirus in the brain of a harbor seal.

    Directory of Open Access Journals (Sweden)

    Rogier Bodewes

    Full Text Available Using random PCR in combination with next-generation sequencing, a novel parvovirus was detected in the brain of a young harbor seal (Phoca vitulina with chronic non-suppurative meningo-encephalitis that was rehabilitated at the Seal Rehabilitation and Research Centre (SRRC in the Netherlands. In addition, two novel viruses belonging to the family Anelloviridae were detected in the lungs of this animal. Phylogenetic analysis of the coding sequence of the novel parvovirus, tentatively called Seal parvovirus, indicated that this virus belonged to the genus Erythrovirus, to which human parvovirus B19 also belongs. Although no other seals with similar signs were rehabilitated in SRRC in recent years, a prevalence study of tissues of seals from the same area collected in the period 2008-2012 indicated that the Seal parvovirus has circulated in the harbor seal population at least since 2008. The presence of the Seal parvovirus in the brain was confirmed by real-time PCR and in vitro replication. Using in situ hybridization, we showed for the first time that a parvovirus of the genus Erythrovirus was present in the Virchow-Robin space and in cerebral parenchyma adjacent to the meninges. These findings showed that a parvovirus of the genus Erythrovirus can be involved in central nervous system infection and inflammation, as has also been suspected but not proven for human parvovirus B19 infection.

  16. Novel B19-like parvovirus in the brain of a harbor seal.

    Science.gov (United States)

    Bodewes, Rogier; Rubio García, Ana; Wiersma, Lidewij C M; Getu, Sarah; Beukers, Martijn; Schapendonk, Claudia M E; van Run, Peter R W A; van de Bildt, Marco W G; Poen, Marjolein J; Osinga, Nynke; Sánchez Contreras, Guillermo J; Kuiken, Thijs; Smits, Saskia L; Osterhaus, Albert D M E

    2013-01-01

    Using random PCR in combination with next-generation sequencing, a novel parvovirus was detected in the brain of a young harbor seal (Phoca vitulina) with chronic non-suppurative meningo-encephalitis that was rehabilitated at the Seal Rehabilitation and Research Centre (SRRC) in the Netherlands. In addition, two novel viruses belonging to the family Anelloviridae were detected in the lungs of this animal. Phylogenetic analysis of the coding sequence of the novel parvovirus, tentatively called Seal parvovirus, indicated that this virus belonged to the genus Erythrovirus, to which human parvovirus B19 also belongs. Although no other seals with similar signs were rehabilitated in SRRC in recent years, a prevalence study of tissues of seals from the same area collected in the period 2008-2012 indicated that the Seal parvovirus has circulated in the harbor seal population at least since 2008. The presence of the Seal parvovirus in the brain was confirmed by real-time PCR and in vitro replication. Using in situ hybridization, we showed for the first time that a parvovirus of the genus Erythrovirus was present in the Virchow-Robin space and in cerebral parenchyma adjacent to the meninges. These findings showed that a parvovirus of the genus Erythrovirus can be involved in central nervous system infection and inflammation, as has also been suspected but not proven for human parvovirus B19 infection.

  17. HMSRP Hawaiian Monk Seal Handling Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains records for all handling and measurement of Hawaiian monk seals since 1981. Live seals are handled and measured during a variety of events...

  18. Film riding seals for rotary machines

    Science.gov (United States)

    Bidkar, Rahul Anil; Sarawate, Neelesh Nandkumar; Wolfe, Christopher Edward; Ruggiero, Eric John; Raj Mohan, Vivek Raja

    2017-03-07

    A seal assembly for a rotary machine is provided. The seal assembly includes multiple sealing device segments disposed circumferentially intermediate to a stationary housing and a rotor. Each of the segments includes a shoe plate with a forward-shoe section and an aft-shoe section having one or more labyrinth teeth therebetween facing the rotor. The sealing device includes a stator interface element having a groove or slot for allowing disposal of a spline seal for preventing segment leakages. The sealing device segment also includes multiple bellow springs or flexures connected to the shoe plate and to the stator interface element. Further, the sealing device segments include a secondary seal integrated with the stator interface element at one end and positioned about the multiple bellow springs or flexures and the shoe plate at the other end.

  19. Legacy HMSRP Hawaiian Monk Seals Observers

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set documents observers that have collected monk seal data as part of the ongoing monk seal population assessment efforts by PSD personnel and cooperating...

  20. Dynamic analysis of noncontacting hydrostatic seals

    International Nuclear Information System (INIS)

    Kokarakis, J.E.; Thomas, J.M.

    1988-01-01

    A troublesome operating history for hydrostatic seals in reactor coolant pumps motivates an investigation of the dynamics of a typical seal system. A dynamic model of the seal ring is formulated and the response of the seal to transient and steady excitation is analyzed. The model is capable of treating response of the seal ring to excitation by both pressure fluctuations at the faceplate and/or axial motion of the shaft. It also includes the effects of friction between the secondary seal and the mating insert. Damping, inherent in the fluid film between the seal faceplates, is considered by including dynamic pressure variations due to squeeze. A typical hydrostatic seal is analyzed in the numerical applications to study the interrelation between the design parameters, the stability of the system, and the potential contact between the stationery and rotating faces

  1. HMSRP Hawaiian Monk Seal Entanglement data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data set contains records of all entanglements of Hawaiian monk seals in marine debris. The data set comprises records of seals entangled by derelict fishing...

  2. HMSRP Hawaiian Monk Seal Telemetry Tag Deployments

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project investigates foraging behavior of Hawaiian monk seals by conducting telemetry studies. During these studies, live seals are instrumented with dive...

  3. Legacy HMSRP Hawaiian Monk Seal Ultrasound Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Ultrasound images for measuring the condition of juvenile seals at Laysan Island during 2009-2010, collected when seals were handled as part of the De-Worming Project

  4. HMSRP Hawaiian Monk Seal Crittercam video

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project investigates foraging behavior of Hawaiian monk seals by conducting telemetry studies. During these studies, live seals are instrumented with dive...

  5. HMSRP Hawaiian Monk Seal Argos Location Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project investigates foraging behavior of Hawaiian monk seals by conducting telemetry studies. During these studies, live seals are instrumented with satellite...

  6. Seal Apparatus and Methods to Manufacture Thereof

    Science.gov (United States)

    Richard, James A. (Inventor)

    2013-01-01

    In some implementations, apparatus and methods are provided through which a dynamic cryogenic seal is manufactured. In some implementations, the seal includes a retainer and a spring-seal assembly, the assembly being comprised of a main spring housing and fluorine-containing polymer seals. In some implementations, either a radial seal, or an axial (or "piston seal") is provided. In some implementations, methods of manufacturing the dynamic cryogenic seal are also provided. In some implementations, the methods include assembling the components while either heated or cooled, taking advantage of thermal expansion and contraction, such that there is a strong interference fit between the components at room temperature. In some implementations, this process ensures that the weaker fluorine-containing polymer seal is forced to expand and contract with the stronger retainer and spring and is under constant preload. In some implementations, the fluorine-containing polymer is therefore fluidized and retained, and can not lift off.

  7. Overview of LIDS Docking Seals Development

    Science.gov (United States)

    Dunlap, Patrick; Steinetz, Bruce; Daniels, Christopher

    2009-01-01

    GRC is supporting JSC by developing LIDS main interface seals Seal development and testing is occurring at both sub-scale and full-scale levels: a) Small-scale tests performed to define seal materials and evaluate exposure to space environments. b) Medium-scale testing: 1) Permits evaluation of candidate seal designs at faster pace than for full-scale seals. 2) Leak rates and loads can be scaled up to full-scale for indication of seal performance. c) Full-scale test rigs used for seal development and flight qualification tests and to assess on-orbit anomalies if needed. GRC responsible for delivering flight hardware seals to JSC approx.2013 for integration into LIDS flight units.

  8. Bipolar mixed features - Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study.

    Science.gov (United States)

    Tohen, Mauricio; Gold, Alexandra K; Sylvia, Louisa G; Montana, Rebecca E; McElroy, Susan L; Thase, Michael E; Rabideau, Dustin J; Nierenberg, Andrew A; Reilly-Harrington, Noreen A; Friedman, Edward S; Shelton, Richard C; Bowden, Charles L; Singh, Vivek; Deckersbach, Thilo; Ketter, Terence A; Calabrese, Joseph R; Bobo, William V; McInnis, Melvin G

    2017-08-01

    DSM-5 changed the criteria from DSM-IV for mixed features in mood disorder episodes to include non-overlapping symptoms of depression and hypomania/mania. It is unknown if, by changing these criteria, the same group would qualify for mixed features. We assessed how those meeting DSM-5 criteria for mixed features compare to those meeting DSM-IV criteria. We analyzed data from 482 adult bipolar patients in Bipolar CHOICE, a randomized comparative effectiveness trial. Bipolar diagnoses were confirmed through the MINI International Neuropsychiatric Interview (MINI). Presence and severity of mood symptoms were collected with the Bipolar Inventory of Symptoms Scale (BISS) and linked to DSM-5 and DSM-IV mixed features criteria. Baseline demographics and clinical variables were compared between mood episode groups using ANOVA for continuous variables and chi-square tests for categorical variables. At baseline, the frequency of DSM-IV mixed episodes diagnoses obtained with the MINI was 17% and with the BISS was 20%. Using DSM-5 criteria, 9% of participants met criteria for hypomania/mania with mixed features and 12% met criteria for a depressive episode with mixed features. Symptom severity was also associated with increased mixed features with a high rate of mixed features in patients with mania/hypomania (63.8%) relative to those with depression (8.0%). Data on mixed features were collected at baseline only and thus do not reflect potential patterns in mixed features within this sample across the study duration. The DSM-5 narrower, non-overlapping definition of mixed episodes resulted in fewer patients who met mixed criteria compared to DSM-IV. Copyright © 2017. Published by Elsevier B.V.

  9. Magnetic resonance imaging and radiographic findings of seal finger

    International Nuclear Information System (INIS)

    Marjelund, S.; Tikkakoski, T.; Isokangas, M.; Raeisaenen, S.

    2006-01-01

    Purpose: To describe the magnetic resonance imaging (MRI) and radiographic findings of five patients with seal finger. Material and Methods: The MR images and radiographs of five patients with seal finger were retrospectively evaluated. MRI was performed on four patients in the subacute phase, and follow-up imaging was done on one of them at 5 months. One patient had MRI only at a later stage 5 years after onset. Radiographs were taken three times in the subacute phase and once at a later stage. One patient had had seal finger in another finger previously. Results: Short-tau inversion-recovery (STIR) sequence showed extensive subcutaneous soft tissue edema in all four patients in the subacute phase and tenosynovitis of the flexion tendons in two cases. Three patients had edema in 2-3 phalanges, and effusion in the distal interphalangeal (DIP) joint was seen in one case. At the later stage, no signal pathology in soft tissues or bones was seen in STIR images. In the subacute phase, radiographs showed digital soft-tissue swelling in three patients, and one patient had a narrowed DIP joint, periarticular osteoporosis, and a periosteal reaction. At the later stage, flexion contracture of the finger was seen. Conclusion: In addition to soft-tissue infection, seal finger causes bone marrow edema, tenosynovitis, and effusion in the interphalangeal joints visible as increased signal intensity in STIR images. Radiographs reveal periarticular osteoporosis with loss of cartilage in the subacute phase and flexion contracture at the later stage. MRI (STIR) allows more precise delineation of the inflammatory process compared to radiography

  10. Magnetic resonance imaging and radiographic findings of seal finger

    Energy Technology Data Exchange (ETDEWEB)

    Marjelund, S.; Tikkakoski, T.; Isokangas, M.; Raeisaenen, S. [Oulu Univ. Hospital (Finland). Dept. of Radiology

    2006-12-15

    Purpose: To describe the magnetic resonance imaging (MRI) and radiographic findings of five patients with seal finger. Material and Methods: The MR images and radiographs of five patients with seal finger were retrospectively evaluated. MRI was performed on four patients in the subacute phase, and follow-up imaging was done on one of them at 5 months. One patient had MRI only at a later stage 5 years after onset. Radiographs were taken three times in the subacute phase and once at a later stage. One patient had had seal finger in another finger previously. Results: Short-tau inversion-recovery (STIR) sequence showed extensive subcutaneous soft tissue edema in all four patients in the subacute phase and tenosynovitis of the flexion tendons in two cases. Three patients had edema in 2-3 phalanges, and effusion in the distal interphalangeal (DIP) joint was seen in one case. At the later stage, no signal pathology in soft tissues or bones was seen in STIR images. In the subacute phase, radiographs showed digital soft-tissue swelling in three patients, and one patient had a narrowed DIP joint, periarticular osteoporosis, and a periosteal reaction. At the later stage, flexion contracture of the finger was seen. Conclusion: In addition to soft-tissue infection, seal finger causes bone marrow edema, tenosynovitis, and effusion in the interphalangeal joints visible as increased signal intensity in STIR images. Radiographs reveal periarticular osteoporosis with loss of cartilage in the subacute phase and flexion contracture at the later stage. MRI (STIR) allows more precise delineation of the inflammatory process compared to radiography.

  11. Non Destructive Seal Testing Polymeric Tray

    Science.gov (United States)

    2006-10-01

    School of Enviromental and Biological Science Rutgers, The State University of New Jersey New Brunswick, New Jersey 08903 Principal Investigator...strength, tack seals and seal creep. The following modifications were issued : Jan 20, 2004 0008/01 Add incremental funding to increase total...Technologies”. Most of the “commercial off the shelf” systems are designed to detect seal integrity issues , such as seal contamination, cuts and holes. A

  12. Reactor coolant pump seals: improving their performance

    International Nuclear Information System (INIS)

    Pothier, N.E.; Metcalfe, R.

    1986-06-01

    Large CANDU plants are benefitting from transient-resistant four-year reliable reactor coolant pump seal lifetimes, a direct result of AECL's 20-year comprehensive seal improvement program involving R and D staff, manufacturers, and plant designers and operators. An overview of this program is presented, which covers seal modification design, testing, post-service examination, specialized maintenance and quality control. The relevancy of this technology to Light Water Reactor Coolant Pump Seals is also discussed

  13. Development of simplified rotating plug seal structure

    International Nuclear Information System (INIS)

    Ueta, M.; Ichimiya, M.; Kanaoka, T.; Sekiya, H.; Ueda, S.; Ishibashi, S.

    1991-01-01

    We studied a compact and simplified rotating plug seal structure and conducted experiments for key elements of the concept such us the mechanical seal structure and sodium deposit prevention system. Good characteristics were confirmed for the mechanical seal structure, which utilizes an elastomer seal and thin lathe bearing. Applicability of the density barrier concept was also confirmed as the sodium deposit prevention system. This concept can be applied to actual plants. (author)

  14. [Thinking organization and defense mechanisms in bipolar disorders. Clinical and psychopathological study on bipolar I and bipolar II].

    Science.gov (United States)

    Lo Baido, Rosa; Di Blasi, Marie; Alfano, Pietro; Audino, Palma; Bellavia, Carmela; Blando, Anna Antonia; Merendino, Adelaide; Messina, Rossana; Poma, Maria Luisa; La Grutta, Sabina

    2013-01-01

    The aim of this research is to explore the psychical functioning in bipolar I or bipolar II disorder people through the analysis and comparison of their thought styles and defense patterns. 29 bipolar I and bipolar II people afferent to Palermo University Policlinical Psychriatic Hospital Department were selected during the whole 2009-2010 year. The following tests were administred: Wechsler Adult Intelligent Scale-R (WAIS-R) in order to measure the general cognitive function; Defense Mechanisms Inventory (DMI) in order to measure defense patterns. Afterwards, the results of the two tests were analysed and compared. Bipolar disorder people use cognitive mechanisms and defense strategies that are very different from standard population. Bipolar I subjects show both wider and more serious cognitive deterioration and stricter defense mechanisms than bipolar II subjects. Generally bipolar patients show an immature personality based on archaic mechanisms that can be found in all the spheres of their personality: emotions, cognition, Ego-strength, adaptability to reality. The peculiar achieved cognitive and defense profile leads to important considerations about how psychological strategies can contribute to use "bespoke" treatments for these patients.

  15. Acoustic resonance spectroscopy intrinsic seals

    International Nuclear Information System (INIS)

    Olinger, C.T.; Burr, T.; Vnuk, D.R.

    1994-01-01

    We have begun to quantify the ability of acoustic resonance spectroscopy (ARS) to detect the removal and replacement of the lid of a simulated special nuclear materials drum. Conceptually, the acoustic spectrum of a container establishcs a baseline fingerprint, which we refer to as an intrinsic seal, for the container. Simply removing and replacing the lid changes some of the resonant frequencies because it is impossible to exactly duplicate all of the stress patterns between the lid and container. Preliminary qualitative results suggested that the ARS intrinsic seal could discriminate between cases where a lid has or has not been removed. The present work is directed at quantifying the utility of the ARS intrinsic seal technique, including the technique's sensitivity to ''nuisance'' effects, such as temperature swings, movement of the container, and placement of the transducers. These early quantitative tests support the potential of the ARS intrinsic seal application, but also reveal a possible sensitivity to nuisance effects that could limit environments or conditions under which the technique is effective

  16. Ergonomics and safety of manual bag sealing.

    NARCIS (Netherlands)

    Groot, M.D. de; Bosch, T.; Eikhout, S.M.; Vink, P.

    2005-01-01

    A variety of seals is used to close bags. Each seal has advantages and disadvantages. For shop assistants sealing bags could be a repetitive physically demanding action. Opening and closing the bags again can cause some discomfort or annoyance for consumers. Besides, it is an activity which can

  17. Annular Pressure Seals and Hydrostatic Bearings

    National Research Council Canada - National Science Library

    San Andres, Luis

    2006-01-01

    ..., in particular those handling large density fluids. Highlights on the bulk-flow analysis of annular seals are given with details on the performance of two water seals long and short, featuring the advantages of an anti-swirl brake to enhance the seal...

  18. 19 CFR 113.25 - Seals.

    Science.gov (United States)

    2010-04-01

    ... signatures of principal and surety, if individuals, and the corporate seal shall be affixed close to the... law of the state in which executed. However, when the charter or governing statute of a corporation requires its acts to be evidenced by its corporate seal, such seal is required. ...

  19. 36 CFR 901.6 - Seal.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Seal. 901.6 Section 901.6 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION BYLAWS OF THE CORPORATION § 901.6 Seal. The Corporation may adopt a corporate seal which shall have the name of the...

  20. Piston rod seal for a Stirling engine

    Science.gov (United States)

    Shapiro, Wilbur

    1984-01-01

    In a piston rod seal for a Stirling engine, a hydrostatic bearing and differential pressure regulating valve are utilized to provide for a low pressure differential across a rubbing seal between the hydrogen and oil so as to reduce wear on the seal.

  1. Aerodynamic seal assemblies for turbo-machinery

    Science.gov (United States)

    Bidkar, Rahul Anil; Wolfe, Christopher; Fang, Biao

    2015-09-29

    The present application provides an aerodynamic seal assembly for use with a turbo-machine. The aerodynamic seal assembly may include a number of springs, a shoe connected to the springs, and a secondary seal positioned about the springs and the shoe.

  2. Tribological Tuft Testing Candidate Brush Seal Materials

    Science.gov (United States)

    DellaCorte, Chris

    1999-01-01

    This paper presents a tribological tuft test method of candidate brush seal materials in viewgraph form. The goals of the research are: 1) To develop test method to tribologically brush seal materials; 2) To evaluate materials to identify potential improvements and trends; and 3) Guide seal material development and selection.

  3. Improved sealing for in-core systems

    International Nuclear Information System (INIS)

    Dunford, S.

    1989-01-01

    The in-core instrumentation sealing nozzles designed by Framatome have three mechanical seals in series instead of the one traditional seal, and are pressurized by simply tightening up the nozzle covers. They have been installed from the start on all Framatome PWRs, as well as having been backfitted on Belgium and Yugoslavian units and chosen for the Chinese Qinshan plant. (author)

  4. Dampers for Stationary Labyrinth Seals

    Science.gov (United States)

    El-Aini, Yehia; Mitchell, William; Roberts, Lawrence; Montgomery, Stuart; Davis, Gary

    2011-01-01

    Vibration dampers have been invented that are incorporated as components within the stationary labyrinth seal assembly. These dampers are intended to supplement other vibration-suppressing features of labyrinth seals in order to reduce the incidence of high-cycle-fatigue failures, which have been known to occur in the severe vibratory environments of jet engines and turbopumps in which labyrinth seals are typically used. A vibration damper of this type includes several leaf springs and/or a number of metallic particles (shot) all held in an annular seal cavity by a retaining ring. The leaf springs are made of a spring steel alloy chosen, in conjunction with design parameters, to maintain sufficient preload to ensure effectiveness of damping at desired operating temperatures. The cavity is vented via a small radial gap between the retaining ring and seal housing. The damping mechanism is complex. In the case of leaf springs, the mechanism is mainly friction in the slippage between the seal housing and individual dampers. In the case of a damper that contains shot, the damping mechanism includes contributions from friction between individual particles, friction between particles and cavity walls, and dissipation of kinetic energy of impact. The basic concept of particle/shot vibration dampers has been published previously; what is new here is the use of such dampers to suppress traveling-wave vibrations in labyrinth seals. Damping effectiveness depends on many parameters, including, but not limited to, coefficient of friction, mode shape, and frequency and amplitude of vibrational modes. In tests, preloads of the order of 6 to 15 lb (2.72 to 6.8 kilograms) per spring damper were demonstrated to provide adequate damping levels. Effectiveness of shot damping of vibrations having amplitudes from 20 to 200 times normal terrestrial gravitational acceleration (196 to 1,960 meters per square second) and frequencies up to 12 kHz was demonstrated for shot sizes from 0.032 to

  5. Comparative study on two different seal surface structure for reactor pressure vessel sealing behavior

    International Nuclear Information System (INIS)

    Chen Jun; Xiong Guangming; Deng Xiaoyun

    2014-01-01

    The seal surface structure is very important to reactor pressure vessel (RPV) sealing behavior. In this paper, two 3-D RPV sealing analysis finite models have been established with different seal surface structures, in order to study the influence of two structures. The separation of RPV upper and lower flanges, bolt loads and etc. are obtained, which are used to evaluate the sealing behavior of the RPV. Meanwhile, the comparative analysis of safety margin of two seal surface structural had been done, which provides the theoretical basis for RPV seal structure design optimization. (authors)

  6. Immobilisation of southern elephant seals and leopard seals with cyclohexamine anaesthetics and xylazine.

    Science.gov (United States)

    Mitchell, P J; Burton, H R

    1991-10-12

    Ketamine and xylazine were given to 55 southern elephant seals (Mirounga leonina) for stomach lavaging, and to three leopard seals (Hydrurga leptonyx). The elephant seals showed prolonged apnoea and two of them died owing to aspiration of stomach contents. Two of the leopard seals died from unknown causes. Tiletamine and zolazepam were given to five elephant seals and one leopard seal. Two of the elephant seals and the leopard seal died from unknown causes. Xylazine alone was administered to 34 leopard seals. Sedation was poor at low dose rates (less than 1.7 mg/kg) but four of the seals given higher dose rates died owing to the aspiration of stomach contents.

  7. Poorer sustained attention in bipolar I than bipolar II disorder

    Directory of Open Access Journals (Sweden)

    Chen Shih-Heng

    2010-02-01

    Full Text Available Abstract Background Nearly all information processing during cognitive processing takes place during periods of sustained attention. Sustained attention deficit is among the most commonly reported impairments in bipolar disorder (BP. The majority of previous studies have only focused on bipolar I disorder (BP I, owing to underdiagnosis or misdiagnosis of bipolar II disorder (BP II. With the refinement of the bipolar spectrum paradigm, the goal of this study was to compare the sustained attention of interepisode patients with BP I to those with BP II. Methods In all, 51 interepisode BP patients (22 with BP I and 29 with BP II and 20 healthy controls participated in this study. The severity of psychiatric symptoms was assessed by the 17-item Hamilton Depression Rating Scale and the Young Mania Rating Scale. All participants undertook Conners' Continuous Performance Test II (CPT-II to evaluate sustained attention. Results After controlling for the severity of symptoms, age and years of education, BP I patients had a significantly longer reaction times (F(2,68 = 7.648, P = 0.001, worse detectability (d' values (F(2,68 = 6.313, P = 0.003 and more commission errors (F(2,68 = 6.182, P = 0.004 than BP II patients and healthy controls. BP II patients and controls scored significantly higher than BP I patients for d' (F = 6.313, P = 0.003. No significant difference was found among the three groups in omission errors and no significant correlations were observed between CPT-II performance and clinical characteristics in the three groups. Conclusions These findings suggested that impairments in sustained attention might be more representative of BP I than BP II after controlling for the severity of symptoms, age, years of education and reaction time on the attentional test. A longitudinal follow-up study design with a larger sample size might be needed to provide more information on chronological sustained attention deficit in BP patients, and to illustrate

  8. Swimming in Deep Water: Childhood Bipolar Disorder

    Science.gov (United States)

    Senokossoff, Gwyn W.; Stoddard, Kim

    2009-01-01

    The authors focused on one parent's struggles in finding a diagnosis and intervention for a child who had bipolar disorder. The authors explain the process of identification, diagnosis, and intervention of a child who had bipolar disorder. In addition to the personal story, the authors provide information on the disorder and outline strategies…

  9. Bipolar disorder diagnosis: challenges and future directions

    Science.gov (United States)

    Phillips, Mary L; Kupfer, David J

    2018-01-01

    Bipolar disorder refers to a group of affective disorders, which together are characterised by depressive and manic or hypomanic episodes. These disorders include: bipolar disorder type I (depressive and manic episodes: this disorder can be diagnosed on the basis of one manic episode); bipolar disorder type II (depressive and hypomanic episodes); cyclothymic disorder (hypomanic and depressive symptoms that do not meet criteria for depressive episodes); and bipolar disorder not otherwise specified (depressive and hypomanic-like symptoms that do not meet the diagnostic criteria for any of the aforementioned disorders). Bipolar disorder type II is especially difficult to diagnose accurately because of the difficulty in differentiation of this disorder from recurrent unipolar depression (recurrent depressive episodes) in depressed patients. The identification of objective biomarkers that represent pathophysiologic processes that differ between bipolar disorder and unipolar depression can both inform bipolar disorder diagnosis and provide biological targets for the development of new and personalised treatments. Neuroimaging studies could help the identification of biomarkers that differentiate bipolar disorder from unipolar depression, but the problem in detection of a clear boundary between these disorders suggests that they might be better represented as a continuum of affective disorders. Innovative combinations of neuroimaging and pattern recognition approaches can identify individual patterns of neural structure and function that accurately ascertain where a patient might lie on a behavioural scale. Ultimately, an integrative approach, with several biological measurements using different scales, could yield patterns of biomarkers (biosignatures) to help identify biological targets for personalised and new treatments for all affective disorders. PMID:23663952

  10. Transient Stuttering in Catatonic Bipolar Patients

    Directory of Open Access Journals (Sweden)

    Anthony B. Joseph

    1991-01-01

    Full Text Available Two cases of transient stuttering occurring in association with catatonia and bipolar disorder are described. Affective decompensation has been associated with lateralized cerebral dysfunction, and it is hypothesized that in some bipolar catatonic patients a concomitant disorder of the lateralization of language function may lead to a variety of clinical presentations including aphasia, mutism, and stuttering.

  11. Cognitive behavioral therapy for bipolar disorders

    OpenAIRE

    Lotufo Neto, Francisco

    2004-01-01

    Descrição dos objetivos e principais técnicas da terapia comportamental cognitiva usadas para a psicoterapia das pessoas com transtorno bipolar.Objectives and main techniques of cognitive behavior therapy for the treatment of bipolar disorder patients are described.

  12. NO signaling in retinal bipolar cells.

    Science.gov (United States)

    Agurto, A; Vielma, A H; Cadiz, B; Couve, E; Schmachtenberg, O

    2017-08-01

    Nitric oxide (NO) is a neuromodulator involved in physiological and pathological processes in the retina. In the inner retina, a subgroup of amacrine cells have been shown to synthesize NO, but bipolar cells remain controversial as NO sources. This study correlates NO synthesis in dark-adapted retinas, through labeling with the NO marker DAF-FM, with neuronal nitric oxide synthase (nNOS) and inducible NOS expression, and presence of the NO receptor soluble guanylate cyclase in bipolar cells. NO containing bipolar cells were morphologically identified by dialysis of DAF fluorescent cells with intracellular dyes, or by DAF labeling followed by immunohistochemistry for nNOS and other cellular markers. DAF fluorescence was observed in all types of bipolar cells that could be identified, but the most intense DAF fluorescence was observed in bipolar cells with severed processes, supporting pathological NO signaling. Among nNOS expressing bipolar cells, type 9 was confirmed unequivocally, while types 2, 3a, 3b, 4, 5, 7, 8 and the rod bipolar cell were devoid of this enzyme. These results establish specific bipolar cell types as NO sources in the inner retina, and support the involvement of NO signaling in physiological and pathological processes in the inner retina. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Identification of local myocardial repolarization time by bipolar electrode potential.

    Science.gov (United States)

    Namba, Tsunetoyo; Todo, Takahiro; Yao, Takenori; Ashihara, Takashi; Haraguchi, Ryo; Nakazawa, Kazuo; Ikeda, Takanori; Ohe, Tohru

    2007-01-01

    The aim of this study was to investigate whether bipolar electrode potentials (BEPs) reflect local myocardial repolarization dynamics, using computer simulation. Simulated action potential and BEP mapping of myocardial tissue during fibrillation was performed. The BEP was modified to make all the fluctuations have the same polarity. Then, the modified BEP (mBEP) was transformed to "dynamic relative amplitude" (DRA) designed to make all the fluctuations have the similar amplitude. The repolarization end point corresponded to the end of the repolarization-related small fluctuation that clearly appeared in the DRA of mBEP. Using the DRA of mBEP, we could reproduce the repolarization dynamics in the myocardial tissue during fibrillation. The BEP may facilitate identifying the repolarization time. Furthermore, BEP mapping has the possibility that it would be available for evaluating repolarization behavior in myocardial tissue even during fibrillation. The accuracy of activation-recovery interval was also reconfirmed.

  14. Thyroid Functions and Bipolar Affective Disorder

    Directory of Open Access Journals (Sweden)

    Subho Chakrabarti

    2011-01-01

    Full Text Available Accumulating evidence suggests that hypothalamo-pituitary-thyroid (HPT axis dysfunction is relevant to the pathophysiology and clinical course of bipolar affective disorder. Hypothyroidism, either overt or more commonly subclinical, appears to the commonest abnormality found in bipolar disorder. The prevalence of thyroid dysfunction is also likely to be greater among patients with rapid cycling and other refractory forms of the disorder. Lithium-treatment has potent antithyroid effects and can induce hypothyroidism or exacerbate a preexisting hypothyroid state. Even minor perturbations of the HPT axis may affect the outcome of bipolar disorder, necessitating careful monitoring of thyroid functions of patients on treatment. Supplementation with high dose thyroxine can be considered in some patients with treatment-refractory bipolar disorder. Neurotransmitter, neuroimaging, and genetic studies have begun to provide clues, which could lead to an improved understanding of the thyroid-bipolar disorder connection, and more optimal ways of managing this potentially disabling condition.

  15. Diagnostic stability in pediatric bipolar disorder

    DEFF Research Database (Denmark)

    Vedel Kessing, Lars; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    BACKGROUND: The diagnostic stability of pediatric bipolar disorder has not been investigated previously. The aim was to investigate the diagnostic stability of the ICD-10 diagnosis of pediatric mania/bipolar disorder.METHODS: All patients below 19 years of age who got a diagnosis of mania/bipolar...... disorder at least once in a period from 1994 to 2012 at psychiatric inpatient or outpatient contact in Denmark were identified in a nationwide register.RESULTS: Totally, 354 children and adolescents got a diagnosis of mania/bipolar disorder at least once; a minority, 144 patients (40.7%) got the diagnosis...... at the first contact whereas the remaining patients (210; 59.3%) got the diagnosis at later contacts before age 19. For the latter patients, the median time elapsed from first treatment contact with the psychiatric service system to the first diagnosis with a manic episode/bipolar disorder was nearly 1 year...

  16. 2017 Bipolar Plate Workshop Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Kopasz, John P. [Argonne National Lab. (ANL), Argonne, IL (United States); Benjamin, Thomas G. [Argonne National Lab. (ANL), Argonne, IL (United States); Schenck, Deanna [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-08-17

    The Bipolar Plate (BP) Workshop was held at USCAR1 in Southfield, Michigan on February 14, 2017 and included 63 participants from industry, government agencies, universities, and national laboratories with expertise in the relevant fields. The objective of the workshop was to identify research and development (R&D) needs, in particular early-stage R&D, for bipolar plates for polymer electrolyte membrane (PEM) fuel cells for transportation applications. The focus of the workshop was on materials, manufacturing, and design aspects of bipolar plates with the goal of meeting DOE’s 2020 bipolar plate targets. Of special interest was the cost target of ≤$3/kW for the bipolar plate.

  17. Nanofluidic diode and bipolar transistor.

    Science.gov (United States)

    Daiguji, Hirofumi; Oka, Yukiko; Shirono, Katsuhiro

    2005-11-01

    Theoretical modeling of ionic distribution and transport in a nanochannel containing a surface charge on its wall, 30 nm high and 5 microm long, suggests that ionic current can be controlled by locally modifying the surface charge density through a gate electrode, even if the electrical double layers are not overlapped. When the surface charge densities at the right and left halves of a channel are the same absolute value but of different signs, this could form the basis of a nanofluidic diode. When the surface charge density at the middle part of a channel is modified, this could form the basis of a nanofluidic bipolar transistor.

  18. Development of the seal for nuclear material

    International Nuclear Information System (INIS)

    Lu Feng; Lu Zhao; Zhao Yonggang; Zhang Qixin; Xiao Xuefu

    2000-01-01

    Two kinds of double cap metallic seal and an adhesive seal are developed for the purpose of the accounting for and control of nuclear material. Two kinds of double cap metallic seal are made of stainless steel and copper, respectively and the self-locked technique is used. The number and the random pattern are carved out side and in side of a cap, respectively, for the seal. The random pattern carved inside of a cap for seal is taken a picture using numeral camera and memorized in computer. Special software is developed for verification of the random pattern memorized in computer. The adhesive seal is made of special adhesive paper for purpose of security, and a special pattern guarded against falsification is printed on seal paper using ultraviolet fluorescent light technique

  19. Air riding seal with purge cavity

    Science.gov (United States)

    Sexton, Thomas D; Mills, Jacob A

    2017-08-15

    An air riding seal for a turbine in a gas turbine engine, where an annular piston is axial moveable within an annular piston chamber formed in a stator of the turbine and forms a seal with a surface on the rotor using pressurized air that forms a cushion in a pocket of the annular piston. A purge cavity is formed on the annular piston and is connected to a purge hole that extends through the annular piston to a lower pressure region around the annular piston or through the rotor to an opposite side. The annular piston is sealed also with inner and outer seals that can be a labyrinth seal to form an additional seal than the cushion of air in the pocket to prevent the face of the air riding seal from overheating.

  20. Sealing system for a nuclear reactor

    International Nuclear Information System (INIS)

    McEdwards, J.A.

    1982-01-01

    A nuclear reactor is described which is cooled with a liquid metal and, in particular, the seal for such a nuclear reactor is described. The nuclear reactor includes a vessel, which is closed at the top by a top closure. The top closure consists of a least two components, one of which can rotate. There is an annular gap between the two components. The sealing system in the annular gap consists of at least a first and a second seal which can expand, which are situated in series in the top part of the annular gap. The system also includes an immersed seal: this is arranged in a body made of insulating material. The insulating material body is situated on the underside of the top closure. The immersed seal includes a trough at the lower end of one of the components and a sealing edge, which hangs from the other component and extends downwards into the trough. There is a liquid metal bath in the trough, into which part of the sealing edge projects. The sealing edge has at least one opening above the liquid metal bath. This permits a flow connection between the two spaces on the two sides of the sealing edge, i.e. the space between the immersed seal and the expanding seals on the one hand and the protective gas space within the vessel on the other hand. Further, there is a device by which flushing gas can be introduced into the annular gap between the expanding seals and the sealing edge. The flushing gas is provided to a sufficient extent, so that diffusion of radiaoctive protective gas and sodium vapour upwards to the expanding seals is considerably reduced. The flushing gas mixes with the protective gas in the reactor vessel and can be tapped off there, whereupon it is reprocessed and returned to the vessel. (orig.) [de

  1. Seal dynamics on the Swedish west coast: Scenarios of competition as Baltic grey seal intrude on harbour seal territory

    Science.gov (United States)

    Svensson, Carl Johan

    2012-07-01

    The Kattegat-Skagerrak region on the Swedish west coast is home to an abundant harbour seal population (Phoca vitulina) and a small scattered grey seal population (Halichoerus grypus). In addition, grey seal from the growing population in the Baltic Sea frequently migrate into the Kattegat-Skagerrak. Harbour seals on the west coast of Sweden show relatively high population growth (approximately 9%) compared to the Baltic grey seal in ice-free habitats (approximately 6%), which, in theory, makes harbour seal the stronger competitor of the two in this region. However, incidents of disease in harbour seals that lower population growth are becoming more frequent. These epidemics are primarily caused by the Phocine Distemper Virus (PDV), and may reduce population size with up to 70%. This study models the average development under potential scenarios of competing harbour- and Baltic grey seal populations using Leslie matrices and the Lotka-Volterra model of inter-specific competition. The model is parameterised with previously published data, and resource overlap is incorporated through density dependent pup survival. Using numerical methods short- and long-term abundances are simulated under weak, moderate and strong competition and for different frequencies of PDV epidemics. Results show that the harbour seals are resilient to competition while exerting a negative effect on grey seal abundance under moderate to strong competition. Hence Baltic grey seal benefit from weaker levels of competition. Under moderate and strong competition grey seal abundance is a direct function of the PDV frequency as this reduces the competitive strength of harbour seals. Theoretically this means that higher frequencies of PDV or other pathogens epidemics could facilitate an expansion of Baltic grey seal into Kattegat-Skagerrak. Independent of interaction strength and frequency of epidemics the projected changes to abundances are slow (50-100 years), and even in exceedingly stable

  2. DeepBipolar: Identifying genomic mutations for bipolar disorder via deep learning.

    Science.gov (United States)

    Laksshman, Sundaram; Bhat, Rajendra Rana; Viswanath, Vivek; Li, Xiaolin

    2017-09-01

    Bipolar disorder, also known as manic depression, is a brain disorder that affects the brain structure of a patient. It results in extreme mood swings, severe states of depression, and overexcitement simultaneously. It is estimated that roughly 3% of the population of the United States (about 5.3 million adults) suffers from bipolar disorder. Recent research efforts like the Twin studies have demonstrated a high heritability factor for the disorder, making genomics a viable alternative for detecting and treating bipolar disorder, in addition to the conventional lengthy and costly postsymptom clinical diagnosis. Motivated by this study, leveraging several emerging deep learning algorithms, we design an end-to-end deep learning architecture (called DeepBipolar) to predict bipolar disorder based on limited genomic data. DeepBipolar adopts the Deep Convolutional Neural Network (DCNN) architecture that automatically extracts features from genotype information to predict the bipolar phenotype. We participated in the Critical Assessment of Genome Interpretation (CAGI) bipolar disorder challenge and DeepBipolar was considered the most successful by the independent assessor. In this work, we thoroughly evaluate the performance of DeepBipolar and analyze the type of signals we believe could have affected the classifier in distinguishing the case samples from the control set. © 2017 Wiley Periodicals, Inc.

  3. Comparison of depressive episodes in bipolar disorder and in major depressive disorder within bipolar disorder pedigrees.

    Science.gov (United States)

    Mitchell, Philip B; Frankland, Andrew; Hadzi-Pavlovic, Dusan; Roberts, Gloria; Corry, Justine; Wright, Adam; Loo, Colleen K; Breakspear, Michael

    2011-10-01

    Although genetic epidemiological studies have confirmed increased rates of major depressive disorder among the relatives of people with bipolar affective disorder, no report has compared the clinical characteristics of depression between these two groups. To compare clinical features of depressive episodes across participants with major depressive disorder and bipolar disorder from within bipolar disorder pedigrees, and assess the utility of a recently proposed probabilistic approach to distinguishing bipolar from unipolar depression. A secondary aim was to identify subgroups within the relatives with major depression potentially indicative of 'genetic' and 'sporadic' subgroups. Patients with bipolar disorder types 1 and 2 (n = 246) and patients with major depressive disorder from bipolar pedigrees (n = 120) were assessed using the Diagnostic Interview for Genetic Studies. Logistic regression was used to identify distinguishing clinical features and assess the utility of the probabilistic approach. Hierarchical cluster analysis was used to identify subgroups within the major depressive disorder sample. Bipolar depression was characterised by significantly higher rates of psychomotor retardation, difficulty thinking, early morning awakening, morning worsening and psychotic features. Depending on the threshold employed, the probabilistic approach yielded a positive predictive value ranging from 74% to 82%. Two clusters within the major depressive disorder sample were found, one of which demonstrated features characteristic of bipolar depression, suggesting a possible 'genetic' subgroup. A number of previously identified clinical differences between unipolar and bipolar depression were confirmed among participants from within bipolar disorder pedigrees. Preliminary validation of the probabilistic approach in differentiating between unipolar and bipolar depression is consistent with dimensional distinctions between the two disorders and offers clinical utility in

  4. A YinYang bipolar fuzzy cognitive TOPSIS method to bipolar disorder diagnosis.

    Science.gov (United States)

    Han, Ying; Lu, Zhenyu; Du, Zhenguang; Luo, Qi; Chen, Sheng

    2018-05-01

    Bipolar disorder is often mis-diagnosed as unipolar depression in the clinical diagnosis. The main reason is that, different from other diseases, bipolarity is the norm rather than exception in bipolar disorder diagnosis. YinYang bipolar fuzzy set captures bipolarity and has been successfully used to construct a unified inference mathematical modeling method to bipolar disorder clinical diagnosis. Nevertheless, symptoms and their interrelationships are not considered in the existing method, circumventing its ability to describe complexity of bipolar disorder. Thus, in this paper, a YinYang bipolar fuzzy multi-criteria group decision making method to bipolar disorder clinical diagnosis is developed. Comparing with the existing method, the new one is more comprehensive. The merits of the new method are listed as follows: First of all, multi-criteria group decision making method is introduced into bipolar disorder diagnosis for considering different symptoms and multiple doctors' opinions. Secondly, the discreet diagnosis principle is adopted by the revised TOPSIS method. Last but not the least, YinYang bipolar fuzzy cognitive map is provided for the understanding of interrelations among symptoms. The illustrated case demonstrates the feasibility, validity, and necessity of the theoretical results obtained. Moreover, the comparison analysis demonstrates that the diagnosis result is more accurate, when interrelations about symptoms are considered in the proposed method. In a conclusion, the main contribution of this paper is to provide a comprehensive mathematical approach to improve the accuracy of bipolar disorder clinical diagnosis, in which both bipolarity and complexity are considered. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Core disruptive accident margin seal

    International Nuclear Information System (INIS)

    Garin, J.; Belsick, J.C.

    1978-01-01

    Disclosed is an apparatus for sealing the annulus defined between a substantially cylindrical rotatable first riser assembly and plug combination disposed in a substantially cylindrical second riser assembly and plug combination of a nuclear reactor system. The apparatus comprises a flexible member disposed between the first and second riser components and attached to a metal member which is attached to an actuating mechanism. When the actuating mechanism is not actuated, the flexible member does not contact the riser components thus allowing the free rotation of the riser components. When desired, the actuating mechanism causes the flexible member to contact the first and second riser components in a manner to block the annulus defined between the riser components, thereby sealing the annulus between the riser components

  6. Transport of multiassembly sealed canisters

    International Nuclear Information System (INIS)

    Quinn, R.D.; Lehnert, R.A.; Rosa, J.M.

    1992-01-01

    A significant portion of the commercial spent nuclear fuel in dry storage in the US will be stored in multiassembly sealed canisters before the DOE begins accepting fuel from utilities in 1998. This paper reports that it is desirable from economic and ALARA perspectives to transfer these canisters directly from the plant to the MRS. To this end, it is necessary that the multiassembly sealed canisters, which have been licensed for storage under 10CFR72, be qualified for shipment within a suitable shipping cask under the rules of 10CFR71. Preliminary work performed to date indicates that it is feasible to license a current canister design for transportation, and work is proceeding on obtaining NRC approval

  7. Seals for sealing a pressure vessel such as a nuclear reactor vessel or the like

    International Nuclear Information System (INIS)

    Bruns, H.J.; Huelsermann, K.H.

    1975-01-01

    A description is given of seals for sealing a pressure vessel such as a nuclear reactor vessel, steam boiler vessel, or any other vessel which is desirably sealed against pressure of the type including a housing and a housing closure that present opposed vertical sealing surfaces which define the sides of a channel. The seals of the present invention comprise at least one sealing member disposed in the channel, having at least one stop face, a base portion and two shank portions extending from the base portion to form a groove-like recess. The shank portions are provided with sealing surfaces arranged to mate with the opposed vertical pressure vessel sealing surfaces. A shank-spreading wedge element also disposed in the channel has at least one stop face and is engaged in the groove-like recess with the sealing member and wedge element stop face adjacent to each other

  8. Can neuroimaging disentangle bipolar disorder?

    Science.gov (United States)

    Hozer, Franz; Houenou, Josselin

    2016-05-01

    Bipolar disorder heterogeneity is large, leading to difficulties in identifying neuropathophysiological and etiological mechanisms and hindering the formation of clinically homogeneous patient groups in clinical trials. Identifying markers of clinically more homogeneous groups would help disentangle BD heterogeneity. Neuroimaging may aid in identifying such groups by highlighting specific biomarkers of BD subtypes or clinical dimensions. We performed a systematic literature search of the neuroimaging literature assessing biomarkers of relevant BD phenotypes (type-I vs. II, presence vs. absence of psychotic features, suicidal behavior and impulsivity, rapid cycling, good vs. poor medication response, age at onset, cognitive performance and circadian abnormalities). Consistent biomarkers were associated with suicidal behavior, i.e. frontal/anterior alterations (prefrontal and cingulate grey matter, prefrontal white matter) in patients with a history of suicide attempts; and with cognitive performance, i.e. involvement of frontal and temporal regions, superior and inferior longitudinal fasciculus, right thalamic radiation, and corpus callosum in executive dysfunctions. For the other dimensions and sub-types studied, no consistent biomarkers were identified. Studies were heterogeneous both in methodology and outcome. Though theoretically promising, neuroimaging has not yet proven capable of disentangling subtypes and dimensions of bipolar disorder, due to high between-study heterogeneity. We issue recommendations for future studies. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Seal for fluid forming tools

    Science.gov (United States)

    Golovashchenko, Sergey Fedorovich [Beverly Hills, MI; Bonnen, John Joseph Francis [Milford, MI

    2012-03-20

    An electro-hydraulic forming tool for forming a sheet metal blank in a one-sided die has first and second rigid rings that engage opposite sides of a sheet metal blank. The rigid rings are contained within slots on a die portion and a hydraulic force applicator portion of the forming tool. The seals are either resiliently biased by an elastomeric member or inherently resiliently biased into contact with the blank.

  10. Brief Report: A Family Risk Study Exploring Bipolar Spectrum Problems and Cognitive Biases in Adolescent Children of Bipolar Parents

    Science.gov (United States)

    Espie, Jonathan; Jones, Steven H.; Vance, Yvonne H.; Tai, Sara J.

    2012-01-01

    Children of parents with bipolar disorder are at increased risk of bipolar spectrum diagnoses. This cross-sectional study explores cognitive factors in the prediction of vulnerability to bipolar disorder. Adolescents at high-risk (with a parent with bipolar disorder; n = 23) and age and gender matched adolescents (n = 24) were recruited. Parent…

  11. Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants

    NARCIS (Netherlands)

    Altshuler, LL; Suppes, T; Nolen, WA; Leverich, G; Keck, PE; Frye, MA; Kupka, R; McElroy, SL; Grunze, H; Kitchen, CMR; Post, R; Black, D.O.

    Objectives: The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder. Method: In a 10-week trial, 184 outpatients with bipolar depression (134 with bipolar I disorder, 48 with

  12. Identification of ciguatoxins in Hawaiian monk seals Monachus schauinslandi from the Northwestern and Main Hawaiian Islands.

    Science.gov (United States)

    Bottein, Marie-Yasmine Dechraoui; Kashinsky, Lizabeth; Wang, Zhihong; Littnan, Charles; Ramsdell, John S

    2011-06-15

    Ciguatoxins are potent algal neurotoxins that concentrate in fish preyed upon by the critically endangered Hawaiian monk seal (Monachus schauinslandi). The only report for Hawaiian monk seal exposure to ciguatoxins occurred during a 1978 mortality event when two seal liver extracts tested positive by mouse bioassay. Ciguatoxins were thus proposed as a potential threat to the Hawaiian monk seal population. To reinvestigate monk seal exposure to ciguatoxins we utilized more selective detection methods, the Neuro-2A cytotoxicity assay, to quantify ciguatoxin activity and an analytical method LC-MS/MS to confirm the molecular structure. Tissue analysis from dead stranded animals revealed ciguatoxin activity in brain, liver, and muscle, whereas analysis of blood samples from 55 free-ranging animals revealed detectable levels of ciguatoxin activity (0.43 to 5.49 pg/mL P-CTX-1 equiv) in 19% of the animals. Bioassay-guided LC fractionation of two monk seal liver extracts identified several ciguatoxin-like peaks of activity including a peak corresponding to the P-CTX-3C which was confirmed present by LC-MS/MS. In conclusion, this work provides first confirmation that Hawaiian monk seals are exposed to significant levels of ciguatoxins and first evidence of transfer of ciguatoxin to marine mammals. This threat could pose management challenges for this endangered marine mammal species.

  13. Steam Turbine Flow Path Seals (a Review)

    Science.gov (United States)

    Neuimin, V. M.

    2018-03-01

    Various types of shroud, diaphragm, and end seals preventing idle leak of working steam are installed in the flow paths of steam turbine cylinders for improving their efficiency. Widely known labyrinth seals are most extensively used in the Russian turbine construction industry. The category of labyrinth seals also includes seals with honeycomb inserts. The developers of seals with honeycomb inserts state that the use of such seals makes it possible to achieve certain gain due to smaller leaks of working fluid and more reliable operation of the system under the conditions in which the rotor rotating parts may rub against the stator elements. However, a positive effect can only be achieved if the optimal design parameters of the honeycomb structure are fulfilled with due regard to the specific features of its manufacturing technology and provided that this structure is applied in a goal-seeking manner in the seals of steam and gas turbines and compressors without degrading their vibration stability. Calculated and preliminary assessments made by experts testify that the replacement of conventional labyrinth seals by seals with honeycomb inserts alone, due to which the radial gaps in the shroud seal can be decreased from 1.5 to 0.5 mm, allows the turbine cylinder efficiency to be increased at the initial stage by approximately 1% with the corresponding gain in the turbine set power output. The use of rectangular-cellular seals may result, according to estimates made by their developers, in a further improvement of turbine efficiency by 0.5-1.0%. The labor input required to fabricate such seals is six to eight times smaller than that to fabricate labyrinth seals with honeycomb inserts. Recent years have seen the turbine construction companies of the United States and Germany advertising the use of abradable (sealing) coatings (borrowed from the gas turbine construction technology) in the turbine designs instead of labyrinth seals. The most efficient performance of

  14. Design optimization of seal structure for sealing liquid by magnetic fluids

    International Nuclear Information System (INIS)

    Liu Tonggang; Cheng Yusheng; Yang Zhiyi

    2005-01-01

    The durability of the magnetic fluid seal clearly decreases when sealing another liquid because of the interface instability caused by the applied magnetic field and the velocity difference of the two liquids. With an intention to establish a stable interface during sealing liquid, a new magnetic fluid seal was developed in this paper. The parameters of the structure were optimized by a simulation apparatus. And the magnetic fluid seal designed based on the optimum parameters shows good performance and long life for sealing lubricating oil

  15. Violence in schizophrenia and bipolar disorder.

    Science.gov (United States)

    Volavka, Jan

    2013-03-01

    Although most psychiatric patients are not violent, serious mental illness is associated with increased risk of violent behavior. Most of the evidence available pertains to schizophrenia and bipolar disorder. MEDLINE data base was searched for articles published between 1966 and November 2012 using the combination of key words 'schizophrenia' or 'bipolar disorder' with 'aggression' or 'violence'. For the treatment searches, generic names were used in combination with key words 'schizophrenia' or 'bipolar disorder' and 'aggression' No language constraint was applied. Only articles dealing with adults were included. The lists of references were searched manually to find additional articles. There were statistically significant increases of risk of violence in schizophrenia and in bipolar disorder in comparison with general population. The evidence suggests that the risk of violence is greater in bipolar disorder than in schizophrenia. Most of the violence in bipolar disorder occurs during the manic phase. The risk of violence in schizophrenia and bipolar disorder is increased by comorbid substance use disorder. Violence among adults with schizophrenia may follow at least two distinct pathways-one associated with antisocial conduct, and another associated with the acute psychopathology of schizophrenia. Clozapine is the most effective treatment of aggressive behavior in schizophrenia. Emerging evidence suggests that olanzapine may be the second line of treatment. Treatment adherence is of key importance. Non-pharmacological methods of treatment of aggression in schizophrenia and bipolar disorder are increasingly important. Cognitive behavioral approaches appear to be effective in cases where pharmacotherapy alone does not suffice. Violent behavior of patients with schizophrenia and bipolar disorder is a public health problem. Pharmacological and non-pharmacological approaches should be used to treat not only violent behavior, but also contributing comorbidities such

  16. Quantitative differences in the pineal ultrastructure of perinatal and adult harp (Phoca groenlandica) and hooded seals (Cystophora cristata).

    Science.gov (United States)

    Aarseth, Jo Jorem; Stokkan, Karl-Arne

    2003-10-01

    Seals are unique among mammals in that newborns have a large pineal gland and extremely high plasma levels of melatonin at birth. Melatonin levels are also high in the seal fetus but decline rapidly during the first few days of life. The aim of the present study was to provide quantitative information about the ultrastructure of the seal pineal gland using fetal, newborn, and adult hooded seals (Cystophora cristata), and newborn and adult harp seals (Phoca groenlandica). The relative and absolute volumes of pinealocytes (Pi), arteries and veins, nerves, connective tissue, capillaries and glial cells, as well as mitocondria and lipid droplets in Pi, were calculated by use of point count analysis. Whereas the pineal ultrastructure was similar in fetuses and newborns, both seal species showed a pronounced and particular reduction in the volume of Pi and a similar reduction in pinealocyte mitochondria. There was also a shift from unmyelinated to myelinated pineal nerves in adults compared with fetal/newborns. The selective and marked reduction of Pi may explain the zonated pineal structure typical of the adult seal. The results demonstrate that the fetal gland is as large and active as that of the newborn seal and support the notion that the large size and high activity of the pineal gland in the newborn seal is a fading consequence of its prenatal condition.

  17. Tratamento do transtorno bipolar: eutimia Bipolar disorder treatment: euthymia

    Directory of Open Access Journals (Sweden)

    Fábio Gomes de Matos e Souza

    2005-01-01

    Full Text Available O transtorno bipolar é um quadro complexo caracterizado por episódios de depressão, mania ou hipomania e fases assintomáticas. O tratamento visa ao controle de episódios agudos e prevenção de novos episódios. O tratamento farmacológico iniciou-se com o lítio. Até o momento, o lítio permanece como o tratamento com mais evidências favoráveis na fase de manutenção. Outros tratamentos demonstram eficácia nessa fase, como o valproato, a carbamazepina e os antipsicóticos atípicos. Dos antipsicóticos atípicos o mais estudado nesta fase do tratamento é a olanzapina. Mais estudos prospectivos são necessários para confirmar a ação profilática de novos agentes.Bipolar disorder is a complex disorder characterized by depression episodes, mania or hypomania and asymptomatic phases. The treatment aims at the control of acute episodes and prevention of new episodes. The pharmacological treatment was inaugurated with lithium. Until the moment, lithium remains as the treatment with more favorable evidences in the maintenance phase. Other treatments demonstrate efficacy in this phase, as valproate, carbamazepine and atypical antipsychotics. Of the atypical antipsychotics, the most studied in this phase of treatment is olanzapine. More prospective studies are necessary to confirm prophylactic action of new agents.

  18. Ionizing radiations simulation on bipolar components

    International Nuclear Information System (INIS)

    Montagner, X.

    1999-01-01

    This thesis presents the ionizing radiation effects on bipolar components and more specially their behavior facing the total dose. The first part is devoted to the radiation environments with a special attention to the spatial environments and new emergent environments. The specificities of bipolar components are then presented and their behavior facing the interactions. The physical mechanisms bound to the dose rate are also discussed. The second part presents a physical analysis of degradations induced by the cumulated dosimetry on bipolar components and simulation with the ATLAS code. The third part exposes an electric empirical simulation induced by the cumulated dose in static conditions. (A.L.B.)

  19. Bipolar Disorder and Early Affective Trauma.

    Science.gov (United States)

    de Codt, Aloise; Monhonval, Pauline; Bongaerts, Xavier; Belkacemi, Ikram; Tecco, Juan Martin

    2016-09-01

    Bipolar disorder is a chronic psychiatric disease with a high prevalence and is a major psychosocial and medical burden. The exact etiological pathways of bipolar disorder are not fully understood. Genetic factors are known to play an important role in the etiology of bipolar disorder. However, high rates of discordance among identical twins and a growing body of evidence that environmental factors such as early stress can influence the onset and course of psychiatric diseases underline the importance of additional etiological mechanisms of bipolar disorders. There has been little investigation about early trauma in bipolar disorder. The aim of this study was to review the literature on the association between early traumatic interactions like child neglect, mistreatment, abuse or early parental separation and the occurrence of bipolar disorder in adulthood or impact on the course of the disease. Studies investigating associations between child neglect, mistreatment, abuse or early parental separation and occurrence of bipolar disorder in adulthood or impact on the course of the disease were searched in the Pubmed database. More than 700 articles were sorted independently by two of the authors using predefined criteria. Only research articles, reviews and meta-analyses were selected for this review. 53 articles met the inclusion criteria. To date, four systematic reviews partially addressed our research question. Early trauma is more frequently found in the past of bipolar patients than in the general population. Studies support a harmful effect of childhood trauma on the course of bipolar disease, with more anxious, depressive or psychotic symptoms, an early age of onset and a worse prognosis. Early trauma is more often found in the past of bipolar adult patients than the general population and studies support a harmful effect of childhood trauma on the course of bipolar disease, with more anxious, depressive or psychotic symptoms, an early age of onset and a

  20. Cognitive Behavioral Therapy in Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Zeynep Mackali

    2011-12-01

    Full Text Available Bipolar disorder is an early-onset, chronic disorder. It impairs occupational, social, and family functioning, which makes learning to adapt living with the disorder and its treatment critically important. Therefore, it has now become common knowledge that psychosocial interventions are also necessary in the treatment of bipolar disorder adjunctive to pharmacotherapy. Thus, whichever psychosocial interventions are more effective in bipolar disorder is a crucial research question. In this article, cognitive-behavioral therapy, which is applied adjunctive to pharmacotherapy, will be addressed and the findings of research about the effectiveness of these applications will be reviewed.

  1. Sexuality and Sexual Dysfunctions in Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Zeynep Namli

    2016-12-01

    Full Text Available In the clinical course of bipolar disorder, there is a reduction in sexual will during depressive episodes and inappopriate sexual experiences and hypersexuality occurs during manic episodes. Up to now, studies focused on sexual side effects of drugs. Sexual violence, sexually transmitted diseases, contraception methods, unplanned pregnancies need to be assessed carefully in bipolar disorder patients. This review focused on sexuality and sexual dysfunctions in the course of bipolar disorder. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(4.000: 309-320

  2. Evaluation of Marginal Sealing in Adhesives Restorations After the Use of a Papain Gel

    OpenAIRE

    Natália Costa ARAÚJO; Ana Paula Barbosa de OLIVEIRA; Verônica Maria de Sá RODRIGUES; Patrícia Maria M. da Silva ANDRADE

    2007-01-01

    Objective: Evaluate the sealing conditions of adhesive restorations after the chemomechanical removal of carious tissue with a papain gel (Papacarie®) and after the traditional method of caries removal utilizing rotatory instruments. Method: Seventeen human premolars with caries lesions envolving oclusal (enamel marginal) and cervical (dentin marginal) surfaces was used. The sample was divided in two groups: G1 removal of caries tissue with the traditional method G2 removal of caries tissue w...

  3. Progression along the Bipolar Spectrum: A Longitudinal Study of Predictors of Conversion from Bipolar Spectrum Conditions to Bipolar I and II Disorders

    Science.gov (United States)

    Alloy, Lauren B.; Urošević, Snežana; Abramson, Lyn Y.; Jager-Hyman, Shari; Nusslock, Robin; Whitehouse, Wayne G.; Hogan, Michael

    2011-01-01

    Little longitudinal research has examined progression to more severe bipolar disorders in individuals with “soft” bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a non-patient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of “soft” bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS) project. Of 57 individuals with initial cyclothymia or bipolar disorder not otherwise specified (BiNOS) diagnoses, 42.1% progressed to a bipolar II diagnosis and 10.5% progressed to a bipolar I diagnosis. Of 144 individuals with initial bipolar II diagnoses, 17.4% progressed to a bipolar I diagnosis. Consistent with hypotheses derived from the clinical literature and the Behavioral Approach System (BAS) model of bipolar disorder, and controlling for relevant variables (length of follow-up, initial depressive and hypomanic symptoms, treatment-seeking, and family history), high BAS sensitivity (especially BAS Fun Seeking) predicted a greater likelihood of progression to bipolar II disorder, whereas early age of onset and high impulsivity predicted a greater likelihood of progression to bipolar I (high BAS sensitivity and Fun-Seeking also predicted progression to bipolar I when family history was not controlled). The interaction of high BAS and high Behavioral Inhibition System (BIS) sensitivities also predicted greater likelihood of progression to bipolar I. We discuss implications of the findings for the bipolar spectrum concept, the BAS model of bipolar disorder, and early intervention efforts. PMID:21668080

  4. Actively controlled shaft seals for aerospace applications

    Science.gov (United States)

    Salant, Richard F.

    1995-07-01

    This study experimentally investigates an actively controlled mechanical seal for aerospace applications. The seal of interest is a gas seal, which is considerably more compact than previous actively controlled mechanical seals that were developed for industrial use. In a mechanical seal, the radial convergence of the seal interface has a primary effect on the film thickness. Active control of the film thickness is established by controlling the radial convergence of the seal interface with a piezoelectric actuator. An actively controlled mechanical seal was initially designed and evaluated using a mathematical model. Based on these results, a seal was fabricated and tested under laboratory conditions. The seal was tested with both helium and air, at rotational speeds up to 3770 rad/sec, and at sealed pressures as high as 1.48 x 10(exp 6) Pa. The seal was operated with both manual control and with a closed-loop control system that used either the leakage rate or face temperature as the feedback. The output of the controller was the voltage applied to the piezoelectric actuator. The seal operated successfully for both short term tests (less than one hour) and for longer term tests (four hours) with a closed-loop control system. The leakage rates were typically 5-15 slm (standard liters per minute), and the face temperatures were generally maintained below 100C. When leakage rate was used as the feedback signal, the setpoint leakage rate was typically maintained within 1 slm. However, larger deviations occurred during sudden changes in sealed pressure. When face temperature was used as the feedback signal, the setpoint face temperature was generally maintained within 3 C, with larger deviations occurring when the sealed pressure changes suddenly. the experimental results were compared to the predictions from the mathematical model. The model was successful in predicting the trends in leakage rate that occurred as the balance ratio and sealed pressure changed

  5. Vacuum sealing with a spiral grooved gas dynamic seal

    International Nuclear Information System (INIS)

    Sawada, Tadashi

    1979-01-01

    Gas dynamic seals with rectangular spiral grooves are studied theoretically taking the effects of sidewalls of the grooves and the effects of gas compressibility into account, and slip boundary conditions are employed. The results are compared with the existing experimental data and the validity of the theory is confirmed over a wide pressure range except for the extremely low pressures. Suggestions are made regarding the choice of the geometrical dimensions, i.e., aspect ratio, helix angle, clearance parameter and groove width ratio. (author)

  6. Seal analysis technology for reactor pressure vessel

    International Nuclear Information System (INIS)

    Zheng Liangang; Zhang Liping; Yang Yu; Zang Fenggang

    2009-01-01

    There is the coolant with radiation, high temperature and high pressure in the reactor pressure vessel (RPV). It is closely correlated to RPV sealing capability whether the whole nuclear system work well or not. The aim of this paper is to study the seal analysis method and technology, such as the pre-tensioning of the bolt, elastoplastic contact and coupled technology of thermal and structure. The 3 D elastoplastic seal analysis method really and generally consider the loads and model the contact problem with friction between the contact plates. This method is easier than the specialized seal program and used widely. And it is more really than the 2 D seal analysis method. This 3 D elastoplastic seal analysis method has been successfully used in the design and analysis of RPV. (authors)

  7. Guide to optimized replacement of equipment seals

    International Nuclear Information System (INIS)

    Gleason, J.F.

    1990-03-01

    A reevaluation of current scheduled replacement intervals of polymeric seals in plant equipment can achieve significant benefits. Information is provided which has the potential for increasing replacement intervals based on better information on how seals have performed through unique nuclear industry tests to qualify equipment, improved elastomers and increased knowledge of the failure mechanisms and related performance. The research was performed by reviewing applications of elastomeric seals in nuclear plants and practice associated with defining seal replacement intervals in the nuclear power and other industries. Performance indicators and how they predict degradation of seals were evaluated. Guidelines and a flow chart for reevaluating seal replacement intervals are provided. 29 refs., 38 figs., 8 tabs

  8. Bipolar Electrode Sample Preparation Devices

    Science.gov (United States)

    Wang, Yi (Inventor); Song, Hongjun (Inventor); Pant, Kapil (Inventor)

    2017-01-01

    An analyte selection device can include: a body defining a fluid channel having a channel inlet and channel outlet; a bipolar electrode (BPE) between the inlet and outlet; one of an anode or cathode electrically coupled with the BPE on a channel inlet side of the BPE and the other of the anode or cathode electrically coupled with the BPE on a channel outlet side of the BPE; and an electronic system operably coupled with the anode and cathode so as to polarize the BPE. The fluid channel can have any shape or dimension. The channel inlet and channel outlet can be longitudinal or lateral with respect to the longitudinal axis of the channel. The BPE can be any metallic member, such as a flat plate on a wall or mesh as a barrier BPE. The anode and cathode can be located at a position that polarizes the BPE.

  9. Composite substrate for bipolar electrodes

    Science.gov (United States)

    Tekkanat, Bora; Bolstad, James J.

    1992-12-22

    Substrates for electrode systems, particularly those to be used for bipolar electrodes in zinc-bromine batteries, are disclosed. The substrates preferably include carbon-black as a conductive filler in a polymeric matrix, with reinforcing materials such as glass fibers. Warpage of the zinc-bromine electrodes which was experienced in the prior art and which was believed to be caused by physical expansion of the electrodes due to bromine absorption by the carbon-black, is substantially eliminated when new substrate fabrication techniques are employed. In the pesent invention, substrates are prepared using a lamination process known as glass mat reinforced thermoplastics technology or, in an alternate embodiment, the substrate is made using a slurry process.

  10. A seal analyzer for testing container integrity

    International Nuclear Information System (INIS)

    McDaniel, P.; Jenkins, C.

    1988-01-01

    This paper reports on the development of laboratory and production seal analyzer that offers a rapid, nondestructive method of assuring the seal integrity of virtually any type of single or double sealed container. The system can test a broad range of metal cans, drums and trays, membrane-lidded vessels, flexible pouches, aerosol containers, and glass or metal containers with twist-top lids that are used in the chemical/pesticide (hazardous materials/waste), beverage, food, medical and pharmaceutical industries

  11. Bipolar disorder and neurophysiologic mechanisms

    Directory of Open Access Journals (Sweden)

    Simon M McCrea

    2008-11-01

    Full Text Available Simon M McCreaDepartments of Neurology and Neuroophthalmology, University of British Columbia, 2550 Willow Street, Vancouver, British Columbia, Canada V5Z 3N9Abstract: Recent studies have suggested that some variants of bipolar disorder (BD may be due to hyperconnectivity between orbitofrontal (OFC and temporal pole (TP structures in the dominant hemisphere. Some initial MRI studies noticed that there were corpus callosum abnormalities within specific regional areas and it was hypothesized that developmentally this could result in functional or effective connectivity changes within the orbitofrontal-basal ganglia-thalamocortical circuits. Recent diffusion tensor imaging (DTI white matter fiber tractography studies may well be superior to region of interest (ROI DTI in understanding BD. A “ventral semantic stream” has been discovered connecting the TP and OFC through the uncinate and inferior longitudinal fasciculi and the elusive TP is known to be involved in theory of mind and complex narrative understanding tasks. The OFC is involved in abstract valuation in goal and sub-goal structures and the TP may be critical in binding semantic memory with person–emotion linkages associated with narrative. BD patients have relative attenuation of performance on visuoconstructional praxis consistent with an atypical localization of cognitive functions. Multiple lines of evidence suggest that some BD alleles are being selected for which could explain the enhanced creativity in higher-ability probands. Associations between ROI’s that are not normally connected could explain the higher incidence of artistic aptitude, writing ability, and scientific achievements among some mood disorder subjects.Keywords: bipolar disorder, diffusion tensor imaging, white matter tractography, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, mood dysphoria, creativity, ventral semantic stream, writing ability, artistic aptitude

  12. Development of advanced seals for space propulsion turbomachinery

    Science.gov (United States)

    Hendricks, Robert C.; Liang, Anita D.; Childs, Dara W.; Proctor, Margaret P.

    1992-04-01

    Current activities in seals for space propulsion turbomachinery that NASA sponsors are surveyed. The overall objective is to provide the designer and researcher with the concepts and data to control seal dynamics and leakage. Included in the program are low-leakage seals, such as the brush seal, the 'ceramic rope' seal, low-leakage seals for liquid oxygen turbopumps, face seals for two phase flow, and swirl brakes for stability. Two major efforts are summarized: a seal dynamics in rotating machinery, and an effort in seal code development.

  13. Climatic factors and bipolar affective disorder

    DEFF Research Database (Denmark)

    Christensen, Ellen Margrethe; Larsen, Jens Knud; Gjerris, Annette

    2008-01-01

    In bipolar disorder, the factors provoking a new episode are unknown. As a seasonal variation has been noticed, it has been suggested that weather conditions may play a role. The aim of the study was to elucidate whether meteorological parameters influence the development of new bipolar phases....... A group of patients with at least three previous hospitalizations for bipolar disorder was examined every 3 months for up to 3 years. At each examination an evaluation of the affective phase was made according to the Hamilton Depression Scale (HAM-D(17)), and the Bech-Rafaelsen Mania Rating Scale (MAS......). In the same period, daily recordings from the Danish Meteorological Institute were received. We found no correlations between onset of bipolar episodes [defined as MAS score of 11 or more (mania) and as HAM-D(17) score of 12 or more (depression)] and any meteorological parameters. We found a statistical...

  14. Gene environment interactions in bipolar disorder.

    Science.gov (United States)

    Pregelj, Peter

    2011-09-01

    It has been estimated that the heritable component of bipolar disorder ranges between 80 and 90%. However, even genome-wide association studies explain only a fraction of phenotypic variability not resolving the problem of "lost heritability". Although direct evidence for epigenetic dysfunction in bipolar disorder is still limited, methodological technologies in epigenomic profiling have advanced, offering even single cell analysing and resolving the problem of cell heterogeneity in epigenetics research. Gene overlapping with other mental disorders represents another problem in identifying potential susceptibility genes in bipolar disorder. Better understanding of the interplay between multiple environmental and genetic factors involved in the patogenesis of bipolar disorder could provide relevant information for treatment of patients with this complex disorder. Future studies on the role of these factors in psychopathological conditions, subphenotypes and endophenotypes may greatly benefit by using more precise clinical data and a combined approach with multiple research tools incorporated into a single study.

  15. Are rates of pediatric bipolar disorder increasing?

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2014-01-01

    Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it is unclear whether an increase in rates reflects a true increase in the illness or more...... diagnostic attention. Using nationwide registers of all inpatients and outpatients contacts to all psychiatric hospitals in Denmark, we investigated (1) gender-specific rates of incident pediatric mania/bipolar disorder during a period from 1995 to 2012, (2) whether age and other characteristics...... for pediatric mania/bipolar disorder changed during the calendar period (1995 to 2003 versus 2004 to 2012), and (3) whether the diagnosis is more often made at first psychiatric contact in recent time compared to earlier according to gender. Totally, 346 patients got a main diagnosis of a manic episode (F30...

  16. Internet use by patients with bipolar disorder

    DEFF Research Database (Denmark)

    Bauer, Rita; Conell, Jörn; Glenn, Tasha

    2016-01-01

    There is considerable international interest in online education of patients with bipolar disorder, yet little understanding of how patients use the Internet and other sources to seek information. 1171 patients with a diagnosis of bipolar disorder in 17 countries completed a paper-based, anonymous...... survey. 81% of the patients used the Internet, a percentage similar to the general public. Older age, less education, and challenges in country telecommunications infrastructure and demographics decreased the odds of using the Internet. About 78% of the Internet users looked online for information...... for information on bipolar disorder consulted medical professionals plus a mean of 2.3 other information sources such as books, physician handouts, and others with bipolar disorder. Patients not using the Internet consulted medical professionals plus a mean of 1.6 other information sources. The percentage...

  17. Management of disused sealed sources

    International Nuclear Information System (INIS)

    Lukauskas, D.; Skridaila, N.

    2003-01-01

    The report presents the requirements on management of disused sealed sources in Lithuania; disused sealed source disposal facilities; performed safety analysis and planed repository safety improvements. The requirements on pre-disposal management of Disused Sealed Sources (DSS) are presented. The requirements on disposal of short lived VLLW and LILW (A, B and C classes) radioactive waste approved in 2002-2003. Generic Waste Acceptance Criteria for Near Surface Disposal, P-2003-01 approved in 2003. Requirements on disposal of Low and intermediate level long lived waste do not exist (D and E classes). Requirements for the disposal of disused sealed sources (F class) do not exist. Disposal method for the F class - Near Surface or Deep geological repository, depending on the waste acceptance criteria. Only one repository for institutional radioactive waste exist in Lithuania - Maisiagala repository. It is near surface RADON type disposal facility, built in 1963 and closed in 1988. It was constructed of the monolithic reinforced concrete with the dimensions 5 m x 15 m x 3 m, the thickness of the sidewalls is about 0.25 m and the thickness of the bottom is about 0.2 m. The overall volume is about 200 m 3 . At time of closure only three fifths of the volume had been filled. The empty two fifths of the vault were filled with concrete, then with sand, then with the concrete (0.01 m), hot bitumen and the 0.05 m asphalt layers. Monolithic concrete that was covered with bitumen and 0.05 m thick layer of asphalt closed the vault. Sand layer the thickness of which was not less than 1.2 m formed the cap. Disused radioactive sources embedded in a biological shielding were buried together with their shielding, the sources without the shielding were buried in two stainless steel containers. The total activity of buried radioactive nuclides is 3.42.10 -15 Bq (calculated according the documentation). There are some uncertainties about the inventory: from 1963 to 1973. After the

  18. The Bipolar Illness Onset study: research protocol for the BIO cohort study

    Science.gov (United States)

    Munkholm, Klaus; Faurholt-Jepsen, Maria; Miskowiak, Kamilla Woznica; Nielsen, Lars Bo; Frikke-Schmidt, Ruth; Ekstrøm, Claus; Winther, Ole; Pedersen, Bente Klarlund; Poulsen, Henrik Enghusen; McIntyre, Roger S; Kapczinski, Flavio; Gattaz, Wagner F; Bardram, Jakob; Frost, Mads; Mayora, Oscar; Knudsen, Gitte Moos; Phillips, Mary; Vinberg, Maj

    2017-01-01

    Introduction Bipolar disorder is an often disabling mental illness with a lifetime prevalence of 1%–2%, a high risk of recurrence of manic and depressive episodes, a lifelong elevated risk of suicide and a substantial heritability. The course of illness is frequently characterised by progressive shortening of interepisode intervals with each recurrence and increasing cognitive dysfunction in a subset of individuals with this condition. Clinically, diagnostic boundaries between bipolar disorder and other psychiatric disorders such as unipolar depression are unclear although pharmacological and psychological treatment strategies differ substantially. Patients with bipolar disorder are often misdiagnosed and the mean delay between onset and diagnosis is 5–10 years. Although the risk of relapse of depression and mania is high it is for most patients impossible to predict and consequently prevent upcoming episodes in an individual tailored way. The identification of objective biomarkers can both inform bipolar disorder diagnosis and provide biological targets for the development of new and personalised treatments. Accurate diagnosis of bipolar disorder in its early stages could help prevent the long-term detrimental effects of the illness. The present Bipolar Illness Onset study aims to identify (1) a composite blood-based biomarker, (2) a composite electronic smartphone-based biomarker and (3) a neurocognitive and neuroimaging-based signature for bipolar disorder. Methods and analysis The study will include 300 patients with newly diagnosed/first-episode bipolar disorder, 200 of their healthy siblings or offspring and 100 healthy individuals without a family history of affective disorder. All participants will be followed longitudinally with repeated blood samples and other biological tissues, self-monitored and automatically generated smartphone data, neuropsychological tests and a subset of the cohort with neuroimaging during a 5 to 10-year study period. Ethics

  19. Reusable tamper-indicating security seal

    International Nuclear Information System (INIS)

    Ryan, M.J.

    1981-01-01

    A reusable tamper-indicating mechanical security seal for use in safeguarding nuclear material has been developed. The high-security seal displays an unpredictable, randomly selected, five-digit code each time it is used. This five digit code serves the same purpose that the serial number does for conventional non-reusable seals - a unique identifier for each use or application. The newly developed reusable seal is completely enclosed within a seamless, tamper-indicating, plastic jacket. The jacket is designed to reveal any attempts to penetrate, section or to chemically remove and replace with a counterfeit for surreptitious purposes

  20. Seal for an object containing nuclear fuel

    International Nuclear Information System (INIS)

    Scheuerpflug, W.; Nentwich, D.

    1977-01-01

    This seal which cannot be counterfeited, specially for sealing nuclear objects, e.g. fuel rods, not only makes any damage which has taken place obvious, but makes identification according to a key possible. For this purpose a minimum number of 'particles' or small bodies, which are identical but of different permeability, are fixed inside a short tube during 'loading' of the seal in a certain or an accidental sequence. The sequence of the spheres, which represents a key, can only be determined by special electromagnetic measuring equipment. On first opening the seal, this key sequence is irrevocably destroyed. (HP) [de

  1. Upgrading primary heat transport pump seals

    International Nuclear Information System (INIS)

    Graham, T.; Metcalfe, R.; Rhodes, D.; McInnes, D.

    1995-01-01

    Changes in the operating environment at the Bruce-A Nuclear Generating Station created the need for an upgraded Primary Heat Transport Pump (PHTP) seal. In particular, the requirement for low pressure running during more frequent start-ups exposed a weakness of the CAN2 seal and reduced its reliability. The primary concern at Bruce-A was the rotation of the CAN2 No. 2 stators in their holders. The introduction of low pressure running exacerbated this problem, giving rapid wear of the stator back face, overheating, and thermocracking. In addition, the resulting increase in friction between the stator and its holder increased stationary-side hysteresis and thereby changed the seal characteristic to the point where interseal pressure oscillations became prevalent. The resultant increased hysteresis also led to hard rubbing of the seal faces during temperature transients. An upgraded seal was required for improved reliability to avoid forced outages and to reduce maintenance costs. This paper describes this upgraded 'replacement seal' and its performance history. In spite of the 'teething' problems detailed in this paper, there have been no forced outages due to the replacement seal, and in the words of a seal maintenance worker at Bruce-A, 'it allows me to go home and sleep at night instead of worrying about seal failures.' (author)

  2. Ductile alloys for sealing modular component interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Marra, John J.; Wessell, Brian J.; James, Allister W.; Marsh, Jan H.; Gear, Paul J.

    2017-08-08

    A vane assembly (10) having: an airfoil (12) and a shroud (14) held together without metallurgical bonding there between; a channel (22) disposed circumferentially about the airfoil (12), between the airfoil (12) and the shroud (14); and a seal (20) disposed in the channel (22), wherein during operation of a turbine engine having the vane assembly (10) the seal (20) has a sufficient ductility such that a force generated on the seal (20) resulting from relative movement of the airfoil (12) and the shroud (14) is sufficient to plastically deform the seal (20).

  3. Quick-sealing design for radiological containment

    International Nuclear Information System (INIS)

    Rampdla, D.S.; Speer, E.

    1991-01-01

    This patent describes a quick-sealing assembly and method for forming an adhesive seal on opposite sides of a mechanical seal for a flexible containment bag of the type used for working with radioactively contaminated objects. The assembly includes an elongated mechanical fastener having opposing engaging members affixed at a predetermined distance from each of the elongated edges, with an adhesive layer formed between the mechanical fastener and the elongated edge such that upon engagement of the mechanical fastener and adhesive layers to opposing containment fabric, a neat triple hermetic seal is formed

  4. Quick-sealing design for radiological containment

    International Nuclear Information System (INIS)

    Rampolia, D.S.; Speer, E.

    1990-01-01

    This patent describes a quick-sealing assembly and method for forming an adhesive seal on opposite sides of a mechanical seal for a flexible containment bag of the type used for working with radioactively contaminated objects. The assembly includes an elongated mechanical fastener having opposing engaging members affixed at a predetermined distance from each of the elongated edges, with an adhesive layer formed between the mechanical fastener and the elongated edge such that upon engagement of the mechanical fastener and adhesive layers to opposing containment fabric, a neat triple hermetic seal is formed

  5. Quick-sealing design for radiological containment

    Science.gov (United States)

    Rampolia, Donald S.; Speer, Elmer

    1990-01-01

    A quick-sealing assembly and method for forming an adhesive seal on opposite sides of a mechanical seal for a flexible containment bag of the type used for working with radioactively contaminated objects. The assembly includes an elongated mechanical fastener having opposing engaging members affixed at a predetermined distance from each of the elongated edges, with an adhesive layer formed between the mechanical fastener and the elongated edge such that upon engagement of the mechanical fastener and adhesive layers to opposing containment fabric, a neat triple hermetic seal is formed.

  6. Bingham Sealing and Application in Vacuum Clamping

    Science.gov (United States)

    Yao, S. M.; Teo, Wee Kin; Geng, Zunmin; Turner, Sam; Ridgway, Keith

    2011-12-01

    Vacuum clamping is extensively used in shell machining. In this paper a Bingham Sealing (BS) is presented and formulized based on Bingham plastic performance. The sealing capability of BS is evaluated in various cases. A new Bingham plastic is developed and the yield stress is measured. The performances of "O"ring sealing and BS with the developed Bingham plastic are compared to the static experiment. In this experiment the same vacuum is achieved and the distortion of the blade with BS is better than that with "O" ring sealing.

  7. Bingham Sealing and Application in Vacuum Clamping

    International Nuclear Information System (INIS)

    Yao, S M; Teo, Wee Kin; Geng Zunmin; Turner, Sam; Ridgway, Keith

    2011-01-01

    Vacuum clamping is extensively used in shell machining. In this paper a Bingham Sealing (BS) is presented and formulized based on Bingham plastic performance. The sealing capability of BS is evaluated in various cases. A new Bingham plastic is developed and the yield stress is measured. The performances of Or ing sealing and BS with the developed Bingham plastic are compared to the static experiment. In this experiment the same vacuum is achieved and the distortion of the blade with BS is better than that with 'O' ring sealing.

  8. Byzantine seals from the Ras fortress

    Directory of Open Access Journals (Sweden)

    Ivanišević Vujadin

    2013-01-01

    Full Text Available In this paper, seals found at the location of the Ras fortress (Tvrđava Ras have been published. Inscriptions on these seals show that they used to belong to persons which could be identified with certain military commanders who served under Alexios I Komnenos. The seals in question are: the seals of protonobelissimos Eustathios Kamytzes, Constantine Dalassenos Doukas, protoproedros and doux Constantine Kekaumenos and a certain person called Alexios. [Projekat Ministarstva nauke Republike Srbije, br. 177021 i br. 177032

  9. 48 CFR 14.101 - Elements of sealed bidding.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACT TYPES SEALED BIDDING Use of Sealed Bidding 14.101 Elements of sealed bidding. Sealed bidding is a method of contracting that employs competitive bids, public opening of bids, and... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Elements of sealed bidding...

  10. Ceramic/metal seals. [refractory materials for hermetic seals for lighium-metal sulfide batteries

    Science.gov (United States)

    Bredbenner, A. M.

    1977-01-01

    Design criteria are discussed for a hermetic seal capable of withstanding the 450 C operating temperature of a lithium-metal sulfide battery system. A mechanical seal consisting of two high strength alloy metal sleeves welded or brazed to a conductor assembly and pressed onto a ceramic is described. The conductor center passes through the ceramic but is not sealed to it. The seal is effected on the outside of the taper where the tubular part is pressed down over and makes contact.

  11. Thyroid Functions and Bipolar Affective Disorder

    OpenAIRE

    Chakrabarti, Subho

    2011-01-01

    Accumulating evidence suggests that hypothalamo-pituitary-thyroid (HPT) axis dysfunction is relevant to the pathophysiology and clinical course of bipolar affective disorder. Hypothyroidism, either overt or more commonly subclinical, appears to the commonest abnormality found in bipolar disorder. The prevalence of thyroid dysfunction is also likely to be greater among patients with rapid cycling and other refractory forms of the disorder. Lithium-treatment has potent antithyroid effects and c...

  12. Biological dysrhythm in remitted bipolar I disorder.

    Science.gov (United States)

    Iyer, Aishwarya; Palaniappan, Pradeep

    2017-12-01

    Recent treatment guidelines support treatment of biological rhythm abnormalities as a part of treatment of bipolar disorder, but still, literature examining various domains (Sleep, Activity, Social, and Eating) of biological rhythm and its clinical predictors are less. The main aim of our study is to compare various domains of biological rhythm among remitted bipolar I subjects and healthy controls. We also explored for any association between clinical variables and biological rhythm among bipolar subjects. 40 subjects with Bipolar I disorder and 40 healthy controls who met inclusion and exclusion criteria were recruited for the study. Diagnoses were ascertained by a qualified psychiatrist using MINI 5.0. Sociodemographic details, biological rhythm (BRIAN-Biological Rhythm Interview of assessment in Neuropsychiatry) and Sleep functioning (PSQI- Pittsburgh Sleep Quality Index) were assessed in all subjects. Mean age of the Bipolar subjects and controls were 41.25±11.84years and 38.25±11.25 years respectively. Bipolar subjects experienced more biological rhythm disturbance when compared to healthy controls (total BRIAN score being 34.25±9.36 vs 28.2±6.53) (p=0.002). Subsyndromal depressive symptoms (HDRS) had significant positive correlation with BRIAN global scores(r=0.368, p=0.02). Linear regression analysis showed that number of episodes which required hospitalization (β=0.601, t=3.106, P=0.004), PSQI (β=0.394, t=2.609, p=0.014), HDRS (β=0.376, t=2.34, t=0.036) explained 31% of variance in BRIAN scores in remitted bipolar subjects. Biological rhythm disturbances seem to persist even after clinical remission of bipolar illness. More studies to look into the impact of subsyndromal depressive symptoms on biological rhythm are needed. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Bipolar transistor in VESTIC technology: prototype

    Science.gov (United States)

    Mierzwiński, Piotr; Kuźmicz, Wiesław; Domański, Krzysztof; Tomaszewski, Daniel; Głuszko, Grzegorz

    2016-12-01

    VESTIC technology is an alternative for traditional CMOS technology. This paper presents first measurement data of prototypes of VES-BJT: bipolar transistors in VESTIC technology. The VES-BJT is a bipolar transistor on the SOI substrate with symmetric lateral structure and both emitter and collector made of polysilicon. The results indicate that VES-BJT can be a device with useful characteristics. Therefore, VESTIC technology has the potential to become a new BiCMOS-type technology with some unique properties.

  14. Transtorno afetivo bipolar: um enfoque transcultural

    OpenAIRE

    Sanches,Marsal; Jorge,Miguel Roberto

    2004-01-01

    Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.

  15. Seals at sea: modelling seal distribution in the German bight based on aerial survey data

    NARCIS (Netherlands)

    Herr, H.; Scheidat, M.; Lehnert, K.; Siebert, U.

    2009-01-01

    The Wadden Sea is an important habitat for harbour seals and grey seals. They regularly haul-out on sandbanks and islands along the coast. Comparably little is known about the time seals spend at sea and how they use the remainder of the North Sea. Yet, human activity in offshore waters is

  16. Albinistic common seals (Phoca vitulina) and melanistic grey seals (Halichoerus grypus) rehabilitated in the Netherlands

    NARCIS (Netherlands)

    Osinga, Nynke; 't Hart, Pieter; Vader, Pieter C. van Voorst

    2010-01-01

    The Seal Rehabilitation and Research Centre (SRRC) in Pieterburen, The Netherlands, rehabilitates seals from the waters of the Wadden Sea, North Sea and Southwest Delta area. Incidental observations of albinism and melanism in common and grey seals are known from countries surrounding the North Sea.

  17. O transtorno bipolar na mulher Bipolar disorder in women

    Directory of Open Access Journals (Sweden)

    Alexandro de Borja Gonçalves Guerra

    2005-01-01

    Full Text Available Diferenças sexuais, descritas em vários transtornos psiquiátricos, também parecem estar presentes no transtorno afetivo bipolar (TAB. A prevalência do TAB tipo I se distribui igualmente entre mulheres e homens. Mulheres parecem estar sujeitas a um risco maior de ciclagem rápida e mania mista, condições que fariam do TAB um transtorno com curso mais prejudicial no sexo feminino. Uma diátese depressiva mais marcante, uso excessivo de antidepressivos e diferenças hormonais surgem como hipóteses para explicar essas diferenças fenomenológicas, apesar das quais, mulheres e homens parecem responder igualmente ao tratamento medicamentoso. A indicação de anticonvulsivantes como primeira escolha em mulheres é controversa, a não ser para o tratamento da mania mista e, talvez, da ciclagem rápida. O tratamento do TAB na gravidez deve levar em conta tanto os riscos de exposição aos medicamentos quanto à doença materna. A profilaxia do TAB no puerpério está fortemente indicada em decorrência do grande risco de recorrência da doença nesse período. Embora, de modo geral, as medicações psicotrópicas estejam contra-indicadas durante a amamentação, entre os estabilizadores do humor, a carbamazepina e o valproato são mais seguros do que o lítio. Mais estudos são necessários para a confirmação das diferenças de curso do TAB entre mulheres e homens e a investigação de possíveis diferenças na efetividade dos tratamentos.Gender differences, described in several psychiatric disorders, seem to be also present in bipolar disorder (BD. The prevalence of bipolar I disorder is equally distributed between women and men. Women seem to be at higher risk for rapid cycling and mixed mania, conditions that could make BD a disorder with a more severe course in the female sex. A marked depressive diathesis among women, greatest use of antidepressants and hormonal differences have been mentioned as hypotheses to explain these

  18. Comorbidity bipolar disorder and personality disorders.

    Science.gov (United States)

    Latalova, Klara; Prasko, Jan; Kamaradova, Dana; Sedlackova, Jana; Ociskova, Marie

    2013-01-01

    Outcome in bipolar patients can be affected by comorbidity of other psychiatric disorders. Comorbid personality disorders are frequent and may complicate the course of bipolar illness. We have much information about treating patients with uncomplicated bipolar disorder (BD) but much less knowledge about possibilities for patients with the comorbidity of BD and personality disorder. We conducted a series of literature searches using, as key words or as items in indexed fields, bipolar disorder and personality disorder or personality traits. Articles were obtained by searching MEDLINE from 1970 to 2012. In addition, we used other papers cited in articles from these searches, or cited in articles used in our own work. Tests of personality traits indicated that euthymic bipolar patients have higher scores on harm avoidance, reward dependence, and novelty seeking than controls. Elevation of novelty seeking in bipolar patients is associated with substance abuse comorbidity. Comorbidity with personality disorders in BD patients is associated with a more difficult course of illness (such as longer episodes, shorter time euthymic, and earlier age at onset) and an increase in comorbid substance abuse, suicidality and aggression. These problems are particularly pronounced in comorbidity with borderline personality disorder. Comorbidity with antisocial personality disorder elicits a similar spectrum of difficulties; some of the antisocial behavior exhibited by patients with this comorbidity is mediated by increased impulsivity.

  19. Sexual health and women with bipolar disorder.

    Science.gov (United States)

    McCandless, Fiona; Sladen, Claire

    2003-10-01

    The aim of this paper is to illustrate the importance of sexual health promotion strategies for women with bipolar disorder in order to stimulate interest and debate in this area of care. Sexual health promotion is an important aspect of holistic nursing care. However, the literature indicates that nurses are reluctant to discuss sexual health and sexual behaviour with their clients. People with bipolar disorder warrant special consideration with regards to sexual health because the nature of the manic, or hypomanic, mood state is associated in some cases with sexually risky behaviour. For women with bipolar disorder, the associated risks include the threat of unplanned pregnancy or sexually transmitted diseases. To ignore sexual health and sexual behaviour in mental health care increases the vulnerability of women who may already be at risk of sexual exploitation. CASE EXAMPLE: A brief case example is included to demonstrate how the sexual health of a young woman with bipolar disorder was promoted. The sexual health promotion that was incorporated into her care enabled her to make a choice about appropriate contraception, and also provided her with the opportunity to explore acceptable boundaries in different types of interpersonal relationships. As a result of the episodic nature of Bipolar disorder, it is impossible to state whether the positive outcomes from this strategy will be enduring or not. Consideration of sexual health is an essential element of the care of women with Bipolar disorder. To ignore it is to neglect an important sphere of human behaviour that can be affected by the condition.

  20. The role of sleep in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Gold AK

    2016-06-01

    Full Text Available Alexandra K Gold,1 Louisa G Sylvia,1,2 1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School, Boston, MA, USA Abstract: Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C functioning and sleep–wake homeostasis (process S on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder. A convergence of evidence suggests that sleep problems in bipolar disorder result from dysregulation across both process C and process S systems. Biomarkers of depressive episodes include heightened fragmentation of rapid eye movement (REM sleep, reduced REM latency, increased REM density, and a greater percentage of awakenings, while biomarkers of manic episodes include reduced REM latency, greater percentage of stage I sleep, increased REM density, discontinuous sleep patterns, shortened total sleep time, and a greater time awake in bed. These findings highlight the importance of targeting novel treatments for sleep disturbance in bipolar disorder. Keywords: bipolar disorder, circadian rhythms, sleep–wake homeostasis

  1. Classification of cognitive performance in bipolar disorder.

    Science.gov (United States)

    Sparding, Timea; Silander, Katja; Pålsson, Erik; Östlind, Josefin; Ekman, Carl Johan; Sellgren, Carl M; Joas, Erik; Hansen, Stefan; Landén, Mikael

    2017-09-01

    To understand the etiology of cognitive impairment associated with bipolar disorder, we need to clarify potential heterogeneity in cognitive functioning. To this end, we used multivariate techniques to study if the correlation structure of cognitive abilities differs between persons with bipolar disorder and controls. Clinically stable patients with bipolar disorder (type I: n = 64; type II: n = 44) and healthy controls (n = 86) were assessed with a wide range of cognitive tests measuring executive function, speed, memory, and verbal skills. Data were analysed with multivariate techniques. A distinct subgroup (∼30%) could be identified that performed significantly poorer on tests concerning memory function. This cognitive phenotype subgroup did not differ from the majority of bipolar disorder patients with respect to other demographic or clinical characteristics. Whereas the majority of patients performed similar to controls, a subgroup of patients with bipolar disorder differed substantially from healthy controls in the correlation pattern of low-level cognitive abilities. This suggests that cognitive impairment is not a general trait in bipolar disorder but characteristic of a cognitive subgroup. This has important clinical implications for cognitive rehabilitation and remediation.

  2. Early maladaptive schemas in bipolar disorder.

    Science.gov (United States)

    Ak, Mehmet; Lapsekili, Nergis; Haciomeroglu, Bikem; Sutcigil, Levent; Turkcapar, Hakan

    2012-09-01

    According to the cognitive model of depression, negative schemas, formed in early life, increase susceptibility to depression. The objective of this study was to investigate schemas that are proposed to increase susceptibility of depression in bipolar disorder patients who have had depressive episodes. Eighteen patients diagnosed with bipolar disorder according to DSM-IV and a healthy control group (N= 20) constituted the sample of the study. The Beck Depression Inventory, Young Mania Rating Scale, and Young Schema Scale were applied to patients in order to determine the level of symptoms and schemas. When the scores obtained from Young Schema Scale were compared between groups, significant differences were observed between bipolar patients and control group on all the schemas except abandonment, emotional deprivation, defectiveness, vulnerability to harm or illness, and approval seeking. The negative schema scores of bipolar patients were significantly higher than those of the control group. Of all schemas included in the Young Schema Scale, the scores of bipolar group were higher than the scores of the control group. These findings suggest that, in cognitive-based psychotherapeutic approaches for patients with bipolar disorder, it would be more effective to focus on schemas related to the perception and allowance of feelings at the proper time and the instability of self-perceptions. © 2011 The British Psychological Society.

  3. Preparation of bipolar membranes by electrospinning

    International Nuclear Information System (INIS)

    Pan, Jiefeng; Hou, Linxiao; Wang, Qiuyue; He, Yubin; Wu, Liang; Mondal, Abhishek N.; Xu, Tongwen

    2017-01-01

    A new preparative pathway for the bipolar membranes was initiated via the electrospinning and hot-press process. The prepared bipolar membrane was consisting of sulfonated poly (phenylene oxide), polyethylene glycol, and quaternized poly (phenylene oxide). The above mentioned membrane was fabricated by the continuous electrospinning of the respective layer, followed by the solvent atmosphere treatment and hot-pressing, to obtain a transparent and dense structure. The thickness of each layer can be easily tuned by controlling the electrospinning parameters. The clear interfacial structure was observed and confirmed by the scanning electron microscope. The bipolar performance is evaluated by the current–voltage curves and production yield of acid and base. The final optimized bipolar membrane had similar yield of acid and base as the casting membrane. However, extremely lower potential drop value was observed when they are applied for the production of acid and base. The experimental results showed that, electrospinning is an effective and well controlled way to fabricate bipolar membranes, in which anion or cation exchange layer as well as interfacial layer can be easily changed or added as requested. - Highlights: • Bipolar membranes were prepared through electrospinning followed by post-treatment. • As-prepared membranes were successfully applied in electrodialysis for production of acid and base. • Electrospun membranes exhibit better performance than the casting ones.

  4. Preparation of bipolar membranes by electrospinning

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Jiefeng; Hou, Linxiao; Wang, Qiuyue; He, Yubin; Wu, Liang; Mondal, Abhishek N.; Xu, Tongwen, E-mail: twxu@ustc.edu.cn

    2017-01-15

    A new preparative pathway for the bipolar membranes was initiated via the electrospinning and hot-press process. The prepared bipolar membrane was consisting of sulfonated poly (phenylene oxide), polyethylene glycol, and quaternized poly (phenylene oxide). The above mentioned membrane was fabricated by the continuous electrospinning of the respective layer, followed by the solvent atmosphere treatment and hot-pressing, to obtain a transparent and dense structure. The thickness of each layer can be easily tuned by controlling the electrospinning parameters. The clear interfacial structure was observed and confirmed by the scanning electron microscope. The bipolar performance is evaluated by the current–voltage curves and production yield of acid and base. The final optimized bipolar membrane had similar yield of acid and base as the casting membrane. However, extremely lower potential drop value was observed when they are applied for the production of acid and base. The experimental results showed that, electrospinning is an effective and well controlled way to fabricate bipolar membranes, in which anion or cation exchange layer as well as interfacial layer can be easily changed or added as requested. - Highlights: • Bipolar membranes were prepared through electrospinning followed by post-treatment. • As-prepared membranes were successfully applied in electrodialysis for production of acid and base. • Electrospun membranes exhibit better performance than the casting ones.

  5. Fukushima derived radiocesium in subsistence-consumed northern fur seal and wild celery

    International Nuclear Information System (INIS)

    Ruedig, Elizabeth; Duncan, Colleen; Dickerson, Bobette; Williams, Michael; Gelatt, Thomas; Bell, Justin; Johnson, Thomas E.

    2016-01-01

    In July 2014, our investigative team traveled to St. Paul Island, Alaska to measure concentrations of radiocesium in wild-caught food products, primarily northern fur seal (Callorhinus ursinus). The 2011 Fukushima Daiichi Nuclear Power Plant accident released radiocesium into the atmosphere and into the western Pacific Ocean; other investigators have detected Fukushima-derived radionuclides in a variety of marine products harvested off the western coast of North America. We tested two subsistence-consumed food products from St. Paul Island, Alaska for Fukushima-derived radionuclides: 54 northern fur seal, and nine putchki (wild celery, Angelica lucida) plants. Individual northern fur seal samples were below minimum detectable activity concentrations of 137 Cs and 134 Cs, but when composited, northern fur seal tissues tested positive for trace quantities of both isotopes. Radiocesium was detected at an activity concentration of 37.2 mBq 134 Cs kg −1 f.w. (95% CI: 35.9–38.5) and 141.2 mBq 137 Cs kg −1 f.w. (95% CI: 135.5–146.8). The measured isotopic ratio, decay-corrected to the date of harvest, was 0.26 (95% CI: 0.25–0.28). The Fukushima nuclear accident released 134 Cs and 137 Cs in roughly equal quantities, but by the date of harvest in July 2014, this ratio was 0.2774, indicating that this population of seals has been exposed to small quantities of Fukushima-derived radiocesium. Activity concentrations of both 134 Cs and 137 Cs in putchki were below detection limits, even for composited samples. Northern fur seal is known to migrate between coastal Alaska and Japan and the trace 134 Cs in northern fur seal tissue suggests that the population under study had been minimally exposed Fukushima-derived radionuclides. Despite this inference, the radionuclide quantities detected are small and no impact is expected as a result of the measured radiation exposure, either in northern fur seal or human populations consuming this species. - Highlights:

  6. Corkscrew Seals: Grey Seal (Halichoerus grypus) Infanticide and Cannibalism May Indicate the Cause of Spiral Lacerations in Seals.

    Science.gov (United States)

    Brownlow, Andrew; Onoufriou, Joseph; Bishop, Amanda; Davison, Nicholas; Thompson, Dave

    2016-01-01

    Large numbers of dead seals with characteristic spiral lesions have been washing ashore around the North Atlantic over the past two decades. Interactions with ship propellers and shark predation have been suggested as the likely causal mechanisms. However, new evidence points towards a more likely candidate: grey seal predation. An adult male grey seal was observed and recorded catching, killing and eating five weaned grey seal pups over a period of one week on the Isle of May, Scotland. A further 9 carcasses found in the same area exhibited similar injuries. Post mortem analysis of lesions indicated the wound characteristics were similar to each other and in 12 of the 14 carcasses analysed, were indistinguishable from carcasses previously attributed to propeller interaction. We therefore propose that most of the seal carcasses displaying spiral lacerations in the UK are caused by grey seal predation. Cases in other locations should be re-evaluated using the scoring system presented here to identify whether grey seal predation is a major cause of mortality in phocid seals.

  7. Tratamento da depressão bipolar The treatment of bipolar depression

    Directory of Open Access Journals (Sweden)

    Beny Lafer

    2005-01-01

    Full Text Available O tratamento da depressão bipolar tem sido tema de debate. O uso de antidepressivos, principalmente tricíclicos, nestes pacientes está associado a piores desfechos clínicos. Estudos apontam para uma eficácia limitada de estabilizadores tradicionais como lítio, valproato e carbamazepina no tratamento da depressão bipolar. Em casos de depressão mais grave, há indicativos de que os antidepressivos podem ser úteis, sendo recomendado o uso concomitante de um estabilizador do humor. Novos agentes como a lamotrigina têm sido propostos como efetivos no tratamento da depressão bipolar. Estudos recentes utilizando lamotrigina sugerem a sua eficácia e seguraça no tratamento da depressão bipolar.The treatment of bipolar depression has been an area of debate. The use of antidepressants, particularly the triciclics, has been associated with worse clinical outcomes. Evidence points to a limited efficacy of traditional mood stabilizers such as lithium, valproate and carbamazepine in the treatment of bipolar depression. In cases where depression is more severe, there is evidence that antidepressants may be useful. The use of antidepressants should be in association with a mood stabilizer. New agents such as lamotrigine have been put forward as effective in the treatment of bipolar depression. Recent studies using lamotrigine suggest its efficacy and safety in the treatment of bipolar depression.

  8. Clinical, Demographic, and Familial Correlates of Bipolar Spectrum Disorders among Offspring of Parents with Bipolar Disorder

    Science.gov (United States)

    Goldstein, Benjamin I.; Shamseddeen, Wael; Axelson, David A.; Kalas, Cathy; Monk, Kelly; Brent, David A.; Kupfer, David J.; Birmaher, Boris

    2010-01-01

    Objective: Despite increased risk, most offspring of parents with bipolar disorder (BP) do not manifest BP. The identification of risk factors for BP among offspring could improve preventive and treatment strategies. We examined this topic in the Pittsburgh Bipolar Offspring Study (BIOS). Method: Subjects included 388 offspring, ages 7-17 years,…

  9. Terapia comportamental cognitiva para pessoas com transtorno bipolar Cognitive behavioral therapy for bipolar disorders

    Directory of Open Access Journals (Sweden)

    Francisco Lotufo Neto

    2004-10-01

    Full Text Available Descrição dos objetivos e principais técnicas da terapia comportamental cognitiva usadas para a psicoterapia das pessoas com transtorno bipolar.Objectives and main techniques of cognitive behavior therapy for the treatment of bipolar disorder patients are described.

  10. The miRNome of bipolar disorder.

    Science.gov (United States)

    Fries, Gabriel R; Carvalho, Andre F; Quevedo, Joao

    2018-06-01

    Epigenetic mechanisms have been suggested to play a key role in the pathophysiology of bipolar disorder (BD), among which microRNAs (miRNAs) may be of particular significance according to recent studies. We aimed to summarize miRNA studies in BD to identify consistent findings, limitations, and future directions of this emerging field. We performed a comprehensive search on PUBMED and Medline for studies investigating an association between BD and miRNAs. The included studies report miRNA alterations in postmortem brain tissues and in the periphery, cell culture and preclinical findings, genetic associations, and the effects of medications. Several studies report changes in miRNA expression levels in postmortem brain and in the periphery of patients, although most of the results so far have not been replicated and are not concordant between different populations. Genetic studies also suggest that miRNA genes are located within susceptibility loci of BD, and also a putative role of miRNAs in modulating genes previously shown to confer risk of BD. We did not perform a systematic review of the literature, and miRNAs represent only one facet of the plethora of epigenetic mechanisms that might be involved in BD's pathophysiology. miRNA findings in BD significantly vary between studies, but are consistent to suggest a key role for these molecules in BD's pathophysiology and treatment, particularly miR-34a and miR-137. Accordingly, miRNA might represent important biomarkers of illness to be used in the clinical settings, and potentially also for the development of novel therapeutics for BD in the near future. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. [Circadian markers and genes in bipolar disorder].

    Science.gov (United States)

    Yeim, S; Boudebesse, C; Etain, B; Belliviera, F

    2015-09-01

    Bipolar disorder is a severe and complex multifactorial disease, characterized by alternance of acute episodes of depression and mania/hypomania, interspaced by euthymic periods. The etiological determinants of bipolar disorder yet, are still poorly understood. For the last 30 years, chronobiology is an important field of investigation to better understand the pathophysiology of bipolar disorder. We conducted a review using Medline, ISI Database, EMBase, PsyInfo up to January 2015, using the following keywords combinations: "mood disorder", "bipolar disorder", "depression", "unipolar disorder", "major depressive disorder", "affective disorder", for psychiatric conditions; and "circadian rhythms", "circadian markers", "circadian gene", "clock gene", "melatonin" for circadian rhythms. The search critera was presence of word in any field of the article. Quantitative and qualitative circadian abnormalities are associated with bipolar disorders both during acute episodes and euthymic periods, suggesting that these altered circadian rhythms may represent biological trait markers of the disorder. These circadian dysfunctions were assessed by various validated tools including polysomnography, actigraphy, sleep diaries, chronotype assessments and blood melatonin/cortisol measures. Other altered endogenous circadian activities have also been reported in bipolar patients, such as hormones secretion, core body temperature or fibroblasts activity. Moreover, these markers were also altered in healthy relatives of bipolar patients, suggesting a degree of heritability. Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε. Thus, these circadian gene variants may contribute to the genetic susceptibility of the disease. Furthermore, the study of the clock system may help to better understand some phenotypic aspects like the

  12. A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex.

    Science.gov (United States)

    Wang, Jinglu; Qu, Susu; Wang, Weixiao; Guo, Liyuan; Zhang, Kunlin; Chang, Suhua; Wang, Jing

    2016-11-01

    Numbers of gene expression profiling studies of bipolar disorder have been published. Besides different array chips and tissues, variety of the data processes in different cohorts aggravated the inconsistency of results of these genome-wide gene expression profiling studies. By searching the gene expression databases, we obtained six data sets for prefrontal cortex (PFC) of bipolar disorder with raw data and combinable platforms. We used standardized pre-processing and quality control procedures to analyze each data set separately and then combined them into a large gene expression matrix with 101 bipolar disorder subjects and 106 controls. A standard linear mixed-effects model was used to calculate the differentially expressed genes (DEGs). Multiple levels of sensitivity analyses and cross validation with genetic data were conducted. Functional and network analyses were carried out on basis of the DEGs. In the result, we identified 198 unique differentially expressed genes in the PFC of bipolar disorder and control. Among them, 115 DEGs were robust to at least three leave-one-out tests or different pre-processing methods; 51 DEGs were validated with genetic association signals. Pathway enrichment analysis showed these DEGs were related with regulation of neurological system, cell death and apoptosis, and several basic binding processes. Protein-protein interaction network further identified one key hub gene. We have contributed the most comprehensive integrated analysis of bipolar disorder expression profiling studies in PFC to date. The DEGs, especially those with multiple validations, may denote a common signature of bipolar disorder and contribute to the pathogenesis of disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Machine Vision Inspection of Polymeric Traypack Seal Areas

    National Research Council Canada - National Science Library

    Coburn, John

    2002-01-01

    .... Since entrapped matter can lead to open seals, defects, and seal anomalies, a method of measurement for seal area contamination is useful in quantifying effects of filler changes, line speeds, and product formulations...

  14. Sealing of boreholes using natural, compatible materials: Granular salt

    International Nuclear Information System (INIS)

    Finley, R.E.; Zeuch, D.H.; Stormont, J.C.; Daemen, J.J.K.

    1994-01-01

    Granular salt can be used to construct high performance permanent seals in boreholes which penetrate rock salt formations. These seals are described as seal systems comprised of the host rock, the seal material, and the seal rock interface. The performance of these seal systems is defined by the complex interactions between these seal system components through time. The interactions are largely driven by the creep of the host formation applying boundary stress on the seal forcing host rock permeability with time. The immediate permeability of these seals is dependent on the emplaced density. Laboratory test results suggest that careful emplacement techniques could results in immediate seal system permeability on the order of 10 -16 m 2 to 10 -18 m 2 (10 -4 darcy to 10 -6 ). The visco-plastic behavior of the host rock coupled with the granular salts ability to ''heal'' or consolidate make granular salt an ideal sealing material for boreholes whose permanent sealing is required

  15. Performance oriented guidance for Mississippi chip seals - volume I.

    Science.gov (United States)

    2013-12-01

    A five year laboratory study was conducted to investigate near surface properties of flexible pavements in relation to : how they are affected by bituminous surface treatments. Chip seals and scrub seals (a specialized type of chip seal) : were the f...

  16. Processamento cognitivo "Teoria da Mente" no transtorno bipolar Cognitive "Theory of Mind" processing in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Hélio Anderson Tonelli

    2009-12-01

    Full Text Available OBJETIVO: O transtorno afetivo bipolar está associado ao comprometimento funcional persistente. Apesar de muitas pesquisas demonstrarem que bipolares podem apresentar déficits cognitivos, um número menor de trabalhos avaliou o papel de prejuízos no processamento cognitivo social, a Teoria da Mente (relacionado à capacidade de inferir estados mentais, no aparecimento de sintomas e complicações sociais em bipolares. O objetivo deste trabalho é o de revisar sistemática e criticamente a literatura sobre possíveis alterações do processamento Teoria da Mente no transtorno afetivo bipolar. MÉTODO: Foi realizada uma busca na base de dados Medline por trabalhos publicados em língua inglesa, alemã, espanhola ou portuguesa nos últimos 20 anos, utilizando a frase de busca "Bipolar Disorder"[Mesh] AND "Theory of Mind". Foram procurados por estudos clínicos envolvendo indivíduos bipolares e que empregaram uma ou mais tarefas cognitivas desenvolvidas para a avaliação de habilidades Teoria da Mente. Foram excluídos os relatos de caso e cartas ao editor. A busca inicial resultou em cinco artigos, sendo selecionados quatro. Outros quatro foram também selecionados a partir da leitura dos artigos acima. DISCUSSÃO: Os artigos selecionados avaliaram populações de bipolares adultos e pediátricos, incluindo indivíduos eutímicos, maníacos e deprimidos. A maioria dos trabalhos avaliados sugere que existam prejuízos no processamento Teoria da Mente em portadores de transtorno afetivo bipolar e que estes podem estar por trás dos sintomas e dos déficits funcionais do transtorno afetivo bipolar. CONCLUSÃO: Pesquisas futuras a respeito do tema em questão poderão esclarecer muito acerca do papel das alterações sociocognitivas no surgimento dos sintomas do transtorno afetivo bipolar, bem como ajudar no desenvolvimento de estratégias preventivas e terapêuticas do mesmo.OBJECTIVE: Bipolar disorder is associated to persistent functional

  17. Design, construction and testing of underground seals

    CSIR Research Space (South Africa)

    Cook, AP

    2000-01-01

    Full Text Available the structural design or material requirements for seals, but also require an overpressure of 140 kPa, and this within 24 hours of construction. Approved systems for seal construction from MSHA are concrete blocks, Omega 384 foam blocks, cementitious foam........................................................................................................................ 7 2.1.2 Masonry ....................................................................................................................... 7 2.1.3 Concrete...

  18. Space Environment's Effects on Seal Materials

    Science.gov (United States)

    deGroh, Henry C., III; Daniels, Christopher C.; Dunlap, Patrick; Miller, Sharon; Dever, Joyce; Waters, Deborah; Steinetz, Bruce M.

    2007-01-01

    A Low Impact Docking System (LIDS) is being developed by the NASA Johnson Space Center to support future missions of the Crew Exploration Vehicle (CEV). The LIDS is androgynous, such that each system half is identical, thus any two vehicles or modules with LIDS can be coupled. Since each system half is a replica, the main interface seals must seal against each other instead of a conventional flat metal surface. These sealing surfaces are also expected to be exposed to the space environment when vehicles are not docked. The NASA Glenn Research Center (NASA GRC) is supporting this project by developing the main interface seals for the LIDS and determining the durability of candidate seal materials in the space environment. In space, the seals will be exposed to temperatures of between 50 to 50 C, vacuum, atomic oxygen, particle and ultraviolet radiation, and micrometeoroid and orbital debris (MMOD). NASA GRC is presently engaged in determining the effects of these environments on our candidate elastomers. Since silicone rubber is the only class of seal elastomer that functions across the expected temperature range, NASA GRC is focusing on three silicone elastomers: two provided by Parker Hannifin (S0-899-50 and S0-383-70) and one from Esterline Kirkhill (ELA-SA-401). Our results from compression set, elastomer to elastomer adhesion, and seal leakage tests before and after various simulated space exposures will be presented.

  19. System for inspection of package seal integrity

    Science.gov (United States)

    Gibson, Terry G.

    1995-10-01

    There is an increasing acceptance of reduced waste packaging methods for pharmaceutical and medical products. The high level of product integrity must be maintained, while manufacturing lines are required to increase production rates. To ensure their confidence in these packaging methods, manufacturers have turned to process validation as one method of check. In addition to that effort, automated on-line inspection has become increasingly important. Automated inspection can be used to augment manual inspection techniques that are viable at slower production rates. In this paper we explore the elements of a systematic approach that can provide 100% automatic inspection of product seals at full production rates. The various materials used to seal packages effect the system configuration. One such package sealing material is highly specular (mirror-like) laminated foil. A characteristic of this packaging method is its ability to reflect nearly all of the light from the surface. However, the heat process required to bond the seal to the package creates a coining effect where a uniform, low to medium intensity light source, transmitted at a low incident angle, can be used to identify seal defects. It is equally difficult to inspect package seals that are opaque, translucent, or transparent. Each seal material requires a specific lighting solution. When using reflective material, great care must be taken to develop and integrate the lighting method to an automated package seal inspection system.

  20. Performance evaluation of chip seals in Idaho.

    Science.gov (United States)

    2010-08-01

    The intent of this research project is to identify a wide variety of parameters that influence the performance of pavements treated via chip seals within the State of Idaho. Chip sealing is currently one of the most popular methods of maintenance for...

  1. Population structure of ice-breeding seals.

    Science.gov (United States)

    Davis, Corey S; Stirling, Ian; Strobeck, Curtis; Coltman, David W

    2008-07-01

    The development of population genetic structure in ice-breeding seal species is likely to be shaped by a combination of breeding habitat and life-history characteristics. Species that return to breed on predictable fast-ice locations are more likely to exhibit natal fidelity than pack-ice-breeding species, which in turn facilitates the development of genetic differentiation between subpopulations. Other aspects of life history such as geographically distinct vocalizations, female gregariousness, and the potential for polygynous breeding may also facilitate population structure. Based on these factors, we predicted that fast-ice-breeding seal species (the Weddell and ringed seal) would show elevated genetic differentiation compared to pack-ice-breeding species (the leopard, Ross, crabeater and bearded seals). We tested this prediction using microsatellite analysis to examine population structure of these six ice-breeding species. Our results did not support this prediction. While none of the Antarctic pack-ice species showed statistically significant population structure, the bearded seal of the Arctic pack ice showed strong differentiation between subpopulations. Again in contrast, the fast-ice-breeding Weddell seal of the Antarctic showed clear evidence for genetic differentiation while the ringed seal, breeding in similar habitat in the Arctic, did not. These results suggest that the development of population structure in ice-breeding phocid seals is a more complex outcome of the interplay of phylogenetic and ecological factors than can be predicted on the basis of breeding substrate and life-history characteristics.

  2. Earlier pupping in harbour seals, Phoca vitulina

    NARCIS (Netherlands)

    Reijnders, P.J.H.; Brasseur, S.M.J.M.; Meesters, H.W.G.

    2010-01-01

    The annual reproductive cycle of most seal species is characterized by a tight synchrony of births. Typically, timing of birth shows little inter-annual variation. Here, however we show that harbour seals Phoca vitulina from the Wadden Sea (southeast North Sea) have shortened their yearly cycle,

  3. 39 CFR 2.4 - Seal.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Seal. 2.4 Section 2.4 Postal Service UNITED STATES... Secretary of State, and is required by 39 U.S.C. 207 to be judicially noticed. The Seal shall be in the... description of the Postal Service emblem is described at 39 CFR 221.7. ...

  4. Space Environment Effects on Silicone Seal Materials

    Science.gov (United States)

    deGroh, Henry C., III; Daniels, Christopher C.; Dever, Joyce A.; Miller, Sharon K.; Waters, Deborah L.; Finkbeiner, Joshua R.; Dunlap, Patrick H.; Steinetz, Bruce M.

    2010-01-01

    A docking system is being developed by the NASA to support future space missions. It is expected to use redundant elastomer seals to help contain cabin air during dockings between two spacecraft. The sealing surfaces are exposed to the space environment when vehicles are not docked. In space, the seals will be exposed to temperatures between 125 to -75 C, vacuum, atomic oxygen, particle and ultraviolet radiation, and micrometeoroid and orbital debris (MMOD). Silicone rubber is the only class of space flight-qualified elastomeric seal material that functions across the expected temperature range. NASA Glenn has tested three silicone elastomers for such seal applications: two provided by Parker (S0899-50 and S0383-70) and one from Esterline (ELA-SA-401). The effects of atomic oxygen (AO), UV and electron particle radiation, and vacuum on the properties of these three elastomers were examined. Critical seal properties such as leakage, adhesion, and compression set were measured before and after simulated space exposures. The S0899-50 silicone was determined to be inadequate for extended space seal applications due to high adhesion and intolerance to UV, but both S0383-70 and ELA-SA-401 seals were adequate.

  5. 19 CFR 101.7 - Customs seal.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Customs seal. 101.7 Section 101.7 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY GENERAL PROVISIONS § 101.7 Customs seal. (a) Design. According to the design furnished by the Department...

  6. Dura Seal recommendations for nuclear power plants

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    Reactor systems (BWR, PWR and Candu) are briefly reviewed with reference to the pumping services encountered in each system, to indicate the conditions imposed on mechanical seals for nuclear power plant liquid handling equipment. A description of the Dura Seals used in each service is included. (U.K.)

  7. Sealing Occlusal Dentin Caries in Permanent Molars

    DEFF Research Database (Denmark)

    Qvist, Vibeke; Borum, Mette Kit; Møller, Kirsten Dynes

    2017-01-01

    .001). The median survival time for sealings not replaced by restorations was 7.3 y (CI, 6.4 y to NA). Survival of sealings was increased in patients with low caries risk and/or excellent oral hygiene, second molars compared with first molars, and lesions not extending the middle one-third of the dentin. Survival...

  8. Some anatomical aspects of the cardiovascular system of Antarctic seals and their possible functional significance in diving.

    Science.gov (United States)

    Drabek, C M

    1975-01-01

    The hearts and ascending aortae of 11 Weddell seals, Leptonychotes weddelli, three adult Crabeater seals, Lobodon carcinophagus, two adult Ross seals, Ommatophoca rossi, and one adult Leopard seal, Hydrurga leptonyx, were examined for comparison with terrestrial forms. The Weddell seal specimens were from animals ranging in age from midterm in fetal development to mature adults. All specimens were collected in 1971, 1972, and 1973, from McMurdo Sound and the Ross Sea, Antarctica. The phocid hearts were characteristically broader and flatter than those of other carnivore families and they tended toward bifid apices. The heart form indices (height/circumference) averaged 31.5 compared to 39.0 for felids. The right ventricular chambers of the Antarctic seals were found to average longer in Weddells and narrower in all, than those reported for four other carnivore families. An elastic enlargement was present in the ascending aortae of all seals. The largest diameter of the aortic bulb averaged 25.5 mm more than the base of the aorta in the adult Weddell seals which represented an increase of 72.5% over the base. It is suggested that the general heart form, and especially the ascending aortae, are anatomical adaptations to diving. The compressed heart makes possible unimpaired function when the chest is compressed during deep dives. The aortic bulb maintains mean arterial blood pressure and perfusion of the brain and cardiac tissue during diving bradycardia.

  9. Seroprevalence of Antibodies against Seal Influenza A(H10N7) Virus in Harbor Seals and Gray Seals from the Netherlands

    NARCIS (Netherlands)

    Bodewes, Rogier; Garcia, Ana Rubio; Brasseur, Sophie M.; Conteras, Guillermo J.S.; De Bildt, Van Marco W.G.; Koopmans, Marion P.G.; Osterhaus, Albert D.M.E.; Kuiken, Thijs

    2015-01-01

    In the spring and summer 2014, an outbreak of seal influenza A(H10N7) virus infection occurred among harbor seals (Phoca vitulina) off the coasts of Sweden and Denmark. This virus subsequently spread to harbor seals off the coasts of Germany and the Netherlands. While thousands of seals were

  10. Seroprevalence of Antibodies against Seal Influenza A(H10N7) Virus in Harbor Seals and Gray Seals from the Netherlands

    NARCIS (Netherlands)

    Bodewes, Rogier; Rubio García, Ana; Brasseur, Sophie M; Sanchez Conteras, Guillermo J; van de Bildt, Marco W G; Koopmans, Marion P G; Osterhaus, Albert D M E; Kuiken, Thijs

    2015-01-01

    In the spring and summer 2014, an outbreak of seal influenza A(H10N7) virus infection occurred among harbor seals (Phoca vitulina) off the coasts of Sweden and Denmark. This virus subsequently spread to harbor seals off the coasts of Germany and the Netherlands. While thousands of seals were

  11. The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders

    Science.gov (United States)

    Pacchiarotti, Isabella; Bond, David J.; Baldessarini, Ross J.; Nolen, Willem A.; Grunze, Heinz; Licht, Rasmus W.; Post, Robert M.; Berk, Michael; Goodwin, Guy M.; Sachs, Gary S.; Tondo, Leonardo; Findling, Robert L.; Youngstrom, Eric A.; Tohen, Mauricio; Undurraga, Juan; González-Pinto, Ana; Goldberg, Joseph F.; Yildiz, Ayşegül; Altshuler, Lori L.; Calabrese, Joseph R.; Mitchell, Philip B.; Thase, Michael E.; Koukopoulos, Athanasios; Colom, Francesc; Frye, Mark A.; Malhi, Gin S.; Fountoulakis, Konstantinos N.; Vázquez, Gustavo; Perlis, Roy H.; Ketter, Terence A.; Cassidy, Frederick; Akiskal, Hagop; Azorin, Jean-Michel; Valentí, Marc; Mazzei, Diego Hidalgo; Lafer, Beny; Kato, Tadafumi; Mazzarini, Lorenzo; Martínez-Aran, Anabel; Parker, Gordon; Souery, Daniel; Özerdem, Ayşegül; McElroy, Susan L.; Girardi, Paolo; Bauer, Michael; Yatham, Lakshmi N.; Zarate, Carlos A.; Nierenberg, Andrew A.; Birmaher, Boris; Kanba, Shigenobu; El-Mallakh, Rif S.; Serretti, Alessandro; Rihmer, Zoltan; Young, Allan H.; Kotzalidis, Georgios D.; MacQueen, Glenda M.; Bowden, Charles L.; Ghaemi, S. Nassir; Lopez-Jaramillo, Carlos; Rybakowski, Janusz; Ha, Kyooseob; Perugi, Giulio; Kasper, Siegfried; Amsterdam, Jay D.; Hirschfeld, Robert M.; Kapczinski, Flávio; Vieta, Eduard

    2014-01-01

    Objective The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence is lacking, expert consensus can guide treatment decisions. The International Society for Bipolar Disorders (ISBD) convened a task force to seek consensus recommendations on the use of antidepressants in bipolar disorders. Method An expert task force iteratively developed consensus through serial consensus-based revisions using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new or reworded items and items that needed to be rerated. This process resulted in the final ISBD Task Force clinical recommendations on antidepressant use in bipolar disorder. Results There is striking incongruity between the wide use of and the weak evidence base for the efficacy and safety of antidepressant drugs in bipolar disorder. Few well-designed, long-term trials of prophylactic benefits have been conducted, and there is insufficient evidence for treatment benefits with antidepressants combined with mood stabilizers. A major concern is the risk for mood switch to hypomania, mania, and mixed states. Integrating the evidence and the experience of the task force members, a consensus was reached on 12 statements on the use of antidepressants in bipolar disorder. Conclusions Because of limited data, the task force could not make broad statements endorsing antidepressant use but acknowledged that individual bipolar patients may benefit from antidepressants. Regarding safety, serotonin reuptake inhibitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressants and norepinephrine-serotonin reuptake inhibitors. The frequency and severity of antidepressant-associated mood elevations appear to be greater in bipolar I than bipolar II disorder. Hence, in bipolar I patients antidepressants should be prescribed only as an adjunct to mood-stabilizing medications

  12. Effects of sonic booms on breeding gray seals and harbor seals on Sable Island, Canada.

    Science.gov (United States)

    Perry, Elizabeth A; Boness, Daryl J; Insley, Stephen J

    2002-01-01

    The Concorde produces audible sonic booms as it passes 15 km north of Sable Island, Nova Scotia, where gray and harbor seals occur year round. The purpose of this research was to assess how sonic booms affect these seals. The intensity of the booms was measured and three types of data (beach counts, frequency of behavior, and heart rate) were collected before and after booms during the breeding seasons of the two species. In addition to the data taken during breeding, beach counts were made before and after booms during the gray seal moult. The greatest range in overpressure within a single boom was 2.70 psf during gray seal breeding and 2.07 psf during harbor seal breeding. No significant differences were found in the behavior or beach counts of gray seals following sonic booms, regardless of the season. Beach counts and most behaviors of harbor seals also did not differ significantly following booms, however, harbor seals became more vigilant. The heart rates of four gray seal mothers and three pups showed no clear change as a result of booms, but six male harbor seals showed a nonsignificant tendency toward elevated heart rates during the 15-s interval of the boom. These results suggest sonic booms produced by the Concorde, in level flight at altitude and producing on average a sonic boom of 0.9 psf, do not substantially affect the breeding behavior of gray or harbor seals.

  13. Active Infrared Thermography for Seal Contamination Detection in Heat-Sealed Food Packaging

    Directory of Open Access Journals (Sweden)

    Karlien D’huys

    2016-11-01

    Full Text Available Packaging protects food products from environmental influences, assuring quality and safety throughout shelf life if properly performed. Packaging quality depends on the quality of the packaging material and of the closure or seal. A common problem possibly jeopardizing seal quality is the presence of seal contamination, which can cause a decreased seal strength, an increased packaging failure risk and leak formation. Therefore, early detection and removal of seal contaminated packages from the production chain is crucial. In this work, a pulsed-type active thermography method using the heated seal bars as an excitation source was studied for detecting seal contamination. Thermal image sequences of contaminated seals were recorded shortly after sealing. The detection performances of six thermal image processing methods, based on a single frame, a fit of the cooling profiles, thermal signal reconstruction, pulsed phase thermography, principal component thermography and a matched filter, were compared. High resolution digital images served as a reference to quantify seal contamination, and processed thermal images were mapped to these references. The lowest detection limit (equivalent diameter 0.60 mm was obtained for the method based on a fit of the cooling profiles. Moreover, the detection performance of this method did not depend strongly on the time after sealing at which recording of the thermal images was started, making it a robust and generally applicable method.

  14. Investigations of Shuttle Main Landing Gear Door Environmental Seals

    Science.gov (United States)

    Finkbeiner, Joshua; DeMange, Jeff; Dunlap, Pat; Steinetz, Bruce; Newswander, Daniel

    2006-01-01

    The Columbia Accident investigation Board (CAIB) requested an investigation into the MLG door seals. Initially, the MLG door seals were thought to have been a potential contributor to the loss of Columbia. These suspicions were later found to be untrue, but the seals remained as a cause for concern in future flights. MLG door seals comprised of thermal barrier and environmental seal. This study focuses on the environmental seal for the MLG door.

  15. Spatio-temporal variations and age effect on Toxoplasma gondii seroprevalence in seals from the Canadian Arctic.

    Science.gov (United States)

    Simon, A; Chambellant, M; Ward, B J; Simard, M; Proulx, J F; Levesque, B; Bigras-Poulin, M; Rousseau, A N; Ogden, N H

    2011-09-01

    Toxoplasmosis is a significant public health threat for Inuit in the Canadian Arctic. This study aimed to investigate arctic seals as a possible food-borne source of infection. Blood samples collected from 828 seals in 7 Canadian Arctic communities from 1999 to 2006 were tested for Toxoplasma gondii antibodies using a direct agglutination test. Polymerase chain reaction (PCR) was used to detect T. gondii DNA in tissues of a subsample of seals. Associations between seal age, sex, species, diet, community and year of capture, and serological test results were investigated by logistic regression. Overall seroprevalence was 10·4% (86/828). All tissues tested were negative by PCR. In ringed seals, seroprevalence was significantly higher in juveniles than in adults (odds ratio=2·44). Overall, seroprevalence varied amongst communities (P=0·0119) and by capture year (P=0·0001). Our study supports the hypothesis that consumption of raw seal meat is a significant source of infection for Inuit. This work raises many questions about the mechanism of transfer of this terrestrial parasite to the marine environment, the preponderance of infection in younger animals and the natural course of infection in seals. Further studies to address these questions are essential to fully understand the health risks for Inuit communities.

  16. [Methods for sealing of corneal perforations].

    Science.gov (United States)

    Samoilă, O; Totu, Lăcrămioara; Călugăru, M

    2012-01-01

    A variety of corneal pathology can lead to corneal ulcers and perforations. A deep corneal ulcer may need surgical treatment to allow good volume restoration and reepithelisation. Corneal perforation must be sealed and when the perforation is large, the task of repairing the defect can be underwhelming. The elegant solution is the corneal transplant, but this is not always readily available, especially in undeveloped countries. We present here two cases with different solutions to seal the perforated cornea: the first one has a large peripheral defect and it is successfully sealed with scleral patch and the second one is central with small perforation and is successfully sealed with multilayered amniotic membrane. Both cases are followed for over 12 months and demonstrate good corneal restoration (both on clinical examination and corneal topography). Sclera and amniotic membrane can be used to seal corneal defects when corneal transplant is not readily available.

  17. Properties of Sealing Materials in Groundwater Wells

    DEFF Research Database (Denmark)

    Köser, Claus

    boreholes which in some cases can act as direct openings down to aquifers. The reasons for this may include bad or missing seal. In this context, Schmidt (1999) concluded that there is no proven way to make a clay seal with the desired tightness. This thesis deals primarily with the properties of bentonite...... pellets as sealing material in groundwater wells. The way and the pattern, in which bentonite pellets are deposited, have been shown to have an effect on the swelling pressure of the bentonite seal. During the transport phase of pellets from the terrain to a given sedimentation depth, a sorting process...... on the maximum swelling pressure; i) the bulk density of the sample, and ii) whether the sample is sorted or unsorted. CT scans (Computed Tomography) have been used to evaluate certain properties of bentonite seals in a limited volume. In this context, a set of algorithms to convert CT numbers (HU unit...

  18. Bipolar postpartum depression: An update and recommendations.

    Science.gov (United States)

    Sharma, Verinder; Doobay, Minakshi; Baczynski, Christine

    2017-09-01

    Over the past few years there has been a surge of interest in the study of bipolar postpartum depression (PPD); however, questions remain about its prevalence, screening, clinical features, and treatment. Three electronic databases, MEDLINE/PubMed (1966-2016), PsycINFO (1806-2016), and the Cochrane Database of Systematic Reviews, were searched using a combination of the keywords bipolar, depression, postpartum, peripartum, prevalence, screening, diagnosis, treatment, drugs, and psychotherapy. The reference lists of articles identified were also searched. All relevant articles published in English were included. Depending on the population studied, 21.4-54% of women with PPD have a diagnosis of bipolar disorder (BD). Characteristic clinical features include younger age at illness onset, first onset of depression after childbirth, onset immediately after delivery, atypical depressive symptoms, psychotic features, mixed features, and history of BD in first-degree family members. Treatment should be guided by symptom acuity, safety concerns, the patient's response to past treatments, drug tolerability, and breastfeeding preference. In the absence of controlled treatment data, preference should be given to drugs normally indicated for bipolar depression including lithium, quetiapine and lamotrigine. Although antidepressants have been studied in combination with mood stabilizers in bipolar depression, these drugs should be avoided due to likelihood of elevated risk of induction of manic symptoms in the postpartum period. In the postpartum period, bipolar PPD is common, can be differentiated from unipolar PPD, and needs to be identified promptly in order to expedite appropriate treatment. Future studies on pharmacotherapy and psychotherapy should focus on the acute and preventative treatment of bipolar PPD. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone

    Directory of Open Access Journals (Sweden)

    Jiro Takito

    2018-03-01

    Full Text Available Osteoclasts form a specialized cell–matrix adhesion structure, known as the “sealing zone”, during bone resorption. The sealing zone is a dynamic actin-rich structure that defines the resorption area of the bone. The detailed dynamics and fine structure of the sealing zone have been elusive. Osteoclasts plated on glass do not form a sealing zone, but generate a separate supra-molecular structure called the “podosome belt”. Podosomes are integrin-based adhesion complexes involved in matrix adhesion, cell migration, matrix degradation, and mechanosensing. Invadopodia, podosome-like protrusions in cancer cells, are involved in cell invasion into other tissues by promoting matrix degradation. Both podosomes and invadopodia exhibit actin pattern transitions during maturation. We previously found that Arp2/3-dependent actin flow occurs in all observed assembly patterns of podosomes in osteoclasts on glass. It is known that the actin wave in Dictyostelium cells exhibits a similar pattern transition in its evolution. Because of significant advances in our understanding regarding the mechanism of podosomes/invadopodia formation over the last decade, we revisited the structure and function of the sealing zone in this review, highlighting the possible involvement of self-organized actin waves in the organogenesis of the sealing zone.

  20. The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone.

    Science.gov (United States)

    Takito, Jiro; Inoue, Satoshi; Nakamura, Masanori

    2018-03-26

    Osteoclasts form a specialized cell-matrix adhesion structure, known as the "sealing zone", during bone resorption. The sealing zone is a dynamic actin-rich structure that defines the resorption area of the bone. The detailed dynamics and fine structure of the sealing zone have been elusive. Osteoclasts plated on glass do not form a sealing zone, but generate a separate supra-molecular structure called the "podosome belt". Podosomes are integrin-based adhesion complexes involved in matrix adhesion, cell migration, matrix degradation, and mechanosensing. Invadopodia, podosome-like protrusions in cancer cells, are involved in cell invasion into other tissues by promoting matrix degradation. Both podosomes and invadopodia exhibit actin pattern transitions during maturation. We previously found that Arp2/3-dependent actin flow occurs in all observed assembly patterns of podosomes in osteoclasts on glass. It is known that the actin wave in Dictyostelium cells exhibits a similar pattern transition in its evolution. Because of significant advances in our understanding regarding the mechanism of podosomes/invadopodia formation over the last decade, we revisited the structure and function of the sealing zone in this review, highlighting the possible involvement of self-organized actin waves in the organogenesis of the sealing zone.

  1. Spring loaded compliant seal for high temperature use

    Science.gov (United States)

    Memmen, Robert L; Fedock, John A; Downs, James P

    2013-10-15

    A flexible seal having an X-shaped cross section that forms four contact points on four contact surfaces of two opposed seal slots. The flexible seal is used for a component in which the two seal slots undergo a large deflection such that the opposed slots are not aligned and a rigid seal will not form an adequate seal. The flexible seal can be used in a component of a combustor or a turbine in a gas turbine engine where opposed seal slots undergo the large deflection during operation.

  2. A hybrid floating brush seal (HFBS) for improved sealing and wear performance in turbomachinery applications

    Science.gov (United States)

    Lattime, Scott Byran

    A conceptually new type of seal has been developed for gas turbine applications which dramatically reduces wear and leakage associated with current labyrinth and brush seal technologies. The Hybrid Floating Brush Seal (HFBS) combines brush seal and film riding face seal technologies to create a hybrid seal that allows both axial and radial excursions of the sealed shaft, while simultaneously eliminating interface surface speeds (friction and heat) between the rotor and the brush material that characterize standard brush seal technology. A simple test rig was designed to evaluate feasibility of the HFBS under relatively low pressures and rotational speeds (50psig, 5krpm). A second test stand was created to study the effects of centrifugal force on bristle deflection. A third test facility was constructed for prototype development and extensive room temperature testing at moderate pressures and fairly high rotational speeds (100psig, 40krpm). This test rig also allowed the evaluation of the HFBS during axial movement of a rotating shaft. An analytical model to predict the effects of centrifugal force on the bristles of a rotating brush seal was developed. Room temperature analysis of the HFBS proved successful for relatively high operating rotational velocities at moderate pressures with very acceptable leakage rates for gas turbine engines. Brush seals were able to track rotor speeds up to 24krpm while maintaining sealing integrity. The HFBS's ability to function under axial shaft displacement and synchronous dynamic radial loading was also proven successful. Hydrodynamic performance of the face seal was proven to provide adequate stiffness and load carrying capacity to keep the brush seal from contacting the face seal at pressure drops across the brush of up to 100psi. Leakage performance over standard brush seal and labyrinth technology was quite dramatic. The HFBS showed its sealing advantage using much higher radial interference between the rotor and the bristle

  3. Does the seal licensing system in Scotland have a negative impact on seal welfare?

    Directory of Open Access Journals (Sweden)

    Laetitia Nunny

    2016-08-01

    Full Text Available This study examined the licensing system that permits seal shooting in Scotland, which was established under Part 6 Conservation of Seals of the Marine (Scotland Act 2010. Four approaches were used: data were collated and analyzed from both the Scottish Government and Scottish Marine Animal Stranding Scheme; a survey was sent to current license holders and informal interviews were conducted with key stakeholder types. Between February 2011 and the end of October 2015, 1229 gray seals and 275 common seals were reported shot under license to the Scottish Government. The numbers of seals reported as shot has reduced year-on-year since the licensing system was put in place. While some license holders, notably fish farms, were using some non-lethal forms of deterrent to reduce seal-related damage, these were often used alongside seal shooting. Of the seals reported as shot to the Scottish Government, only a small percentage were also reported to the Scottish Marine Animal Stranding Scheme, despite this being a licensing requirement. Only 2.3% of the shot gray seals and 4.5% of the shot common seals were necropsied. There is evidence from these necropsies that some seals had not died instantly or had not been shot in the manner recommended by the Scottish Seal Management Code of Practice. These preliminary results show that more carcasses need to be recovered and necropsied if the welfare implications of current seal shooting practice are to be properly assessed. The current legislation does not specify closed seasons to protect breeding seals and thirty-five per cent of necropsied seals were pregnant gray seals. Seals have also been shot during their lactation periods when pups are dependent on their mothers. This raises significant welfare concerns. The re-introduction of closed seasons specific to each species of seal is recommended along with greater effort to deploy non-lethal methods. Independent assessment of the number of seals being killed

  4. Levels of non-essential elements in muscle from harp seal (Phagophilus groenlandicus) and hooded seal (Cystophora cristata) caught in the Greenland Sea area

    International Nuclear Information System (INIS)

    Brunborg, Linn Anne; Graff, Ingvild Eide; Froyland, Livar; Julshamn, Kare

    2006-01-01

    The non-essential elements, arsenic, cadmium, mercury and lead, inevitably accumulate in marine top predators such as seals. The concentration of these elements and the essential element selenium, due to its proposed protective properties against mercury toxicity in marine mammals, were measured in muscle, liver and kidney from reproductive active females of harp seal (Phagophilus groenlandicus) and hooded seal (Cystophora cristata) caught in the drift ice between Iceland and East Greenland. Arsenic levels were below 1 μg/g w.w. in all analysed samples, and were therefore low compared to other seafood products. The concentrations of arsenic found in the present study were comparable to the results reported in a similar study from 1985. Mean concentrations of total mercury in muscle from the present study were higher than levels in other seafood products. The levels of total mercury from the present study showed a tendency of lower levels in all tissue samples compared to the study from 1985. Methyl mercury displayed a trend of a lower ratio of methyl mercury to total mercury as the concentration of total mercury increased, indicating a demethylation of methyl mercury at high total mercury concentrations (e.g. mercury in liver of hooded seal). The concentration ratio of methyl mercury to total mercury in muscle samples was more than 75%, with total mercury concentration less than 0.5 μg/g w.w., whereas the ratio for liver was as low as 0.2% with a total mercury concentration of 128 μg/g w.w. The molar concentration ratios of selenium to mercury showed that selenium was present in a molar surplus to mercury in all tissues with low mercury concentration. However, there seemed to be a general mobilisation of selenium in liver and kidney tissues of harp seal and hooded seal, whereas an extraordinary mobilisation seemed to take place at hepatic mercury concentrations exceeding 50 μg/g w.w. The mean concentrations of lead in muscles in the present study were higher

  5. Big data for bipolar disorder.

    Science.gov (United States)

    Monteith, Scott; Glenn, Tasha; Geddes, John; Whybrow, Peter C; Bauer, Michael

    2016-12-01

    The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big data and advances in the ability to analyze these data. The impact of big data on the routine treatment of bipolar disorder today and in the near future is discussed, with examples that relate to health policy, the discovery of new associations, and the study of rare events. The primary sources of big data today are electronic medical records (EMR), claims, and registry data from providers and payers. In the near future, data created by patients from active monitoring, passive monitoring of Internet and smartphone activities, and from sensors may be integrated with the EMR. Diverse data sources from outside of medicine, such as government financial data, will be linked for research. Over the long term, genetic and imaging data will be integrated with the EMR, and there will be more emphasis on predictive models. Many technical challenges remain when analyzing big data that relates to size, heterogeneity, complexity, and unstructured text data in the EMR. Human judgement and subject matter expertise are critical parts of big data analysis, and the active participation of psychiatrists is needed throughout the analytical process.

  6. Bipolar disorder and neurophysiologic mechanisms

    Science.gov (United States)

    McCrea, Simon M

    2008-01-01

    Recent studies have suggested that some variants of bipolar disorder (BD) may be due to hyperconnectivity between orbitofrontal (OFC) and temporal pole (TP) structures in the dominant hemisphere. Some initial MRI studies noticed that there were corpus callosum abnormalities within specific regional areas and it was hypothesized that developmentally this could result in functional or effective connectivity changes within the orbitofrontal-basal ganglia-thalamocortical circuits. Recent diffusion tensor imaging (DTI) white matter fiber tractography studies may well be superior to region of interest (ROI) DTI in understanding BD. A “ventral semantic stream” has been discovered connecting the TP and OFC through the uncinate and inferior longitudinal fasciculi and the elusive TP is known to be involved in theory of mind and complex narrative understanding tasks. The OFC is involved in abstract valuation in goal and sub-goal structures and the TP may be critical in binding semantic memory with person–emotion linkages associated with narrative. BD patients have relative attenuation of performance on visuoconstructional praxis consistent with an atypical localization of cognitive functions. Multiple lines of evidence suggest that some BD alleles are being selected for which could explain the enhanced creativity in higher-ability probands. Associations between ROI’s that are not normally connected could explain the higher incidence of artistic aptitude, writing ability, and scientific achievements among some mood disorder subjects. PMID:19337455

  7. Trends of perfluorochemicals in Greenland ringed seals and polar bears: indications of shifts to decreasing trends.

    Science.gov (United States)

    Rigét, Frank; Bossi, Rossana; Sonne, Christian; Vorkamp, Katrin; Dietz, Rune

    2013-11-01

    Time-series of perfluorinated alkylated substances (PFASs) in East Greenland polar bears and East and West Greenland ringed seals were updated in order to deduce whether a response to the major reduction in perfluoroalkyl production in the early 2000s had occurred. Previous studies had documented an exponential increase of perfluorooctane sulphonate (PFOS) in liver tissue from both species. In the present study, PFOS was still the far most dominant compound constituting 92% (West Greenland ringed seals), 88% (East Greenland ringed seals) and 85% (East Greenland polar bears). The PFOS concentrations increased up to 2006 with doubling times of approximately 6 years for the ringed seal populations and 14 years in case of polar bears. Since then a rapid decrease has occurred with clearing half-lives of approximately 1, 2 and 4 years, respectively. In polar bears perfluorohexane sulphonate (PFHxS) and perfluorooctane sulphonamide (PFOSA) also showed decreasing trends in recent years as do perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnA). For the West Greenland ringed seal population perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), PFDA and PFUnA peaked in the mid 2000s, whereas PFNA, PFDA and PFUnA in the East Greenland population have been stable or increasing in recent years. The peak of PFASs in Greenland ringed seals and polar bears occurred at a later time than in Canadian seals and polar bears and considerably later than observed in seal species from more southern latitudes. We suggest that this could be explained by the distance to emission hot-spots and differences in long-range transport to the Arctic. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. The effects of experimentally induced hyperthyroidism on the diving physiology of harbor seals (Phoca vitulina

    Directory of Open Access Journals (Sweden)

    Gundula M Weingartner

    2012-09-01

    Full Text Available Many phocid seals are expert divers that remain submerged longer than expected based on estimates of oxygen storage and utilization. This discrepancy is most likely due to an overestimation of diving metabolic rate. During diving, a selective redistribution of blood flow occurs, which may result in reduced metabolism in the hypoperfused tissues and a possible decline in whole-body metabolism to below the resting level (hypometabolism. Thyroid hormones are crucial in regulation of energy metabolism in vertebrates and therefore their control might be an important part of achieving a hypometabolic state during diving. To investigate the effect of thyroid hormones on diving physiology of phocid seals, we measured oxygen consumption, heart rate, and post-dive lactate concentrations in five harbor seals (Phoca vitulina conducting 5 min dives on command, in both euthyroid and experimentally induced hyperthyroid states. Oxygen consumption during diving was significantly reduced (by 25 % in both euthyroid and hyperthyroid states, confirming that metabolic rate during diving falls below resting levels. Hyperthyroidism increased oxygen consumption (by 7-8 % when resting in water and during diving, compared with the euthyroid state, illustrating the marked effect of thyroid hormones on metabolic rate. Consequently, post-dive lactate concentrations were significantly increased in the hyperthyroid state, suggesting that the greater oxygen consumption rates forced seals to make increased use of anaerobic metabolic pathways. During diving, hyperthyroid seals also exhibited a more profound decline in heart rate than seals in the euthyroid state, indicating that these seals were pushed towards their aerobic limit and required a more pronounced cardiovascular response. Our results demonstrate the powerful role of thyroid hormones in metabolic regulation and support the hypothesis that thyroid hormones play a role in modulating the at-sea metabolism of phocid seals.

  9. The effects of experimentally induced hyperthyroidism on the diving physiology of harbor seals (Phoca vitulina)

    Science.gov (United States)

    Weingartner, Gundula M.; Thornton, Sheila J.; Andrews, Russel D.; Enstipp, Manfred R.; Barts, Agnieszka D.; Hochachka, Peter W.

    2012-01-01

    Many phocid seals are expert divers that remain submerged longer than expected based on estimates of oxygen storage and utilization. This discrepancy is most likely due to an overestimation of diving metabolic rate. During diving, a selective redistribution of blood flow occurs, which may result in reduced metabolism in the hypoperfused tissues and a possible decline in whole-body metabolism to below the resting level (hypometabolism). Thyroid hormones are crucial in regulation of energy metabolism in vertebrates and therefore their control might be an important part of achieving a hypometabolic state during diving. To investigate the effect of thyroid hormones on diving physiology of phocid seals, we measured oxygen consumption, heart rate, and post-dive lactate concentrations in five harbor seals (Phoca vitulina) conducting 5 min dives on command, in both euthyroid and experimentally induced hyperthyroid states. Oxygen consumption during diving was significantly reduced (by 25%) in both euthyroid and hyperthyroid states, confirming that metabolic rate during diving falls below resting levels. Hyperthyroidism increased oxygen consumption (by 7–8%) when resting in water and during diving, compared with the euthyroid state, illustrating the marked effect of thyroid hormones on metabolic rate. Consequently, post-dive lactate concentrations were significantly increased in the hyperthyroid state, suggesting that the greater oxygen consumption rates forced seals to make increased use of anaerobic metabolic pathways. During diving, hyperthyroid seals also exhibited a more profound decline in heart rate than seals in the euthyroid state, indicating that these seals were pushed toward their aerobic limit and required a more pronounced cardiovascular response. Our results demonstrate the powerful role of thyroid hormones in metabolic regulation and support the hypothesis that thyroid hormones play a role in modulating the at-sea metabolism of phocid seals. PMID:23060807

  10. Bipolar disorder: an update | Outhoff | South African Family Practice

    African Journals Online (AJOL)

    Bipolar disorder, characterised by alternating discrete episodes of (hypo)mania and depression, provides unique diagnostic and treatment challenges. Updated diagnostic (DSM-5) and current pharmacological treatment recommendations are briefly reviewed here. Keywords: bipolar disorder; diagnosis; evidence-based ...

  11. Cytokines in bipolar disorder vs. healthy control subjects

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Braüner, Julie Vestergaard; Kessing, Lars Vedel

    2013-01-01

    Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states....

  12. Assessment of subjective and objective cognitive function in bipolar disorder

    DEFF Research Database (Denmark)

    Demant, Kirsa M; Vinberg, Maj; Kessing, Lars V

    2015-01-01

    Cognitive dysfunction is prevalent in bipolar disorder (BD). However, the evidence regarding the association between subjective cognitive complaints, objective cognitive performance and psychosocial function is sparse and inconsistent. Seventy seven patients with bipolar disorder who presented...

  13. Application of Bipolar Fuzzy Sets in Graph Structures

    Directory of Open Access Journals (Sweden)

    Muhammad Akram

    2016-01-01

    Full Text Available A graph structure is a useful tool in solving the combinatorial problems in different areas of computer science and computational intelligence systems. In this paper, we apply the concept of bipolar fuzzy sets to graph structures. We introduce certain notions, including bipolar fuzzy graph structure (BFGS, strong bipolar fuzzy graph structure, bipolar fuzzy Ni-cycle, bipolar fuzzy Ni-tree, bipolar fuzzy Ni-cut vertex, and bipolar fuzzy Ni-bridge, and illustrate these notions by several examples. We study ϕ-complement, self-complement, strong self-complement, and totally strong self-complement in bipolar fuzzy graph structures, and we investigate some of their interesting properties.

  14. Cardiovascular risk factors in outpatients with bipolar disorder

    NARCIS (Netherlands)

    Klumpers, U.M.H.; Boom, K.; Janssen, F.M.G.; Tulen, J.H.M.; Loonen, Anton J. M.

    2004-01-01

    Background: The mortality due to cardiovascular diseases in bipolar patients is much higher than in the general population. It is unclear whether lithium treatment contributes to this cardiovascular morbidity. Methods: The cardiovascular risk factors in outpatients with bipolar disorder on

  15. Distribution and coassociations of selected metals in seals of the Antarctic.

    Science.gov (United States)

    Szefer, P; Szefer, K; Pempkowiak, J; Skwarzec, B; Bojanowski, R; Holm, E

    1994-01-01

    Zinc, Cu, Cd, Pb, Ag, Ni, Co, Cr, Fe and Mn concentrations in some tissues of crabeater seal (Lobodon carcinophagus), leopard seal (Hydrurga leptonyx) and Weddell seal (Leptonychotes weddelli) from the Antarctic were determined. Distinct inter-tissue differences in metal concentrations in seals were observed; liver contained maximum levels of Zn, Cu, Ag and Mn, whilst kidney showed the highest levels of Cd, Ni and Co. Muscle was characterized by low concentrations of all the elements analyzed. The metal concentrations in the vertebrates analyzed were compared with those for organisms originating from various aquatic areas. Significant correlations were found between the levels of several of the metals analyzed, e.g. between renal and hepatic concentrations of Zn and Cd. Strong relationships between the hepatic concentrations of some metals were found, e.g. Cd-Zn. These two metals also showed a significant coassociation in their renal concentrations. The slope of the regression line for renal Cd/Zn was about three times higher than the hepatic one and this may reflect a relatively high Cd exposure, probably from specific food (squid and krill) provenance, of the seals analyzed.

  16. Ocean climate and seal condition

    Directory of Open Access Journals (Sweden)

    Crocker Daniel E

    2005-03-01

    Full Text Available Abstract Background The condition of many marine mammals varies with fluctuations in productivity and food supply in the ocean basin where they forage. Prey is impacted by physical environmental variables such as cyclic warming trends. The weaning weight of northern elephant seal pups, Mirounga angustirostris, being closely linked to maternal condition, indirectly reflects prey availability and foraging success of pregnant females in deep waters of the northeastern Pacific. The aim of this study was to examine the effect of ocean climate on foraging success in this deep-diving marine mammal over the course of three decades, using cohort weaning weight as the principal metric of successful resource accrual. Results The mean annual weaning weight of pups declined from 1975 to the late 1990s, a period characterized by a large-scale, basin-wide warm decadal regime that included multiple strong or long-duration El Niños; and increased with a return to a cool decadal regime from about 1999 to 2004. Increased foraging effort and decreased mass gain of adult females, indicative of reduced foraging success and nutritional stress, were associated with high ocean temperatures. Conclusion Despite ranging widely and foraging deeply in cold waters beyond coastal thermoclines in the northeastern Pacific, elephant seals are impacted significantly by ocean thermal dynamics. Ocean warming redistributes prey decreasing foraging success of females, which in turn leads to lower weaning mass of pups. Annual fluctuations in weaning mass, in turn, reflect the foraging success of females during the year prior to giving birth and signals changes in ocean temperature cycles.

  17. Study on sealing of boreholes

    International Nuclear Information System (INIS)

    1987-01-01

    A bibliographical research on the problem of the backfilling and sealing of boreholes, shafts and tunnels for radioactive waste disposal has been carried out. Various materials - both natural and artificial - like clay, industrial cement, polymer concrete, geothermical and magnesium cement have been examined. Their main physico-chemical and durability characteristics have been examined. The problem of the interaction between the sealing and the geological environment has been also dealt. The final subject discussed in the bibliography is the damage caused to the host formation by the excavation of shafts and tunnels. The laboratory tests have been performed on a natural clay and other types of material (cement grout, cement grout with expansive additive, cement mortar and remoulded clay) which have been used as plug materials. The main conclusions obtained from the tests are the following: - The permeability of the cement is lower than the permeability of the clay; - no adhesion was observed between clay and cement mortar, with or without expansive additive, when cured under different ambient conditions, but without any application of load; - When curing took place under load, good adhesion was observed between the clay and the cement mortar; - The flow of water in a specimen consisting of a clay core surrounded by remoulded clay is larger than in the natural clay. These results seem to be caused by the different permeabilities of the remoulded and undisturbed clay and not to depend on flow at the contact between the two materials. A remote instrumentation package for the in situ evaluation of the performance of a plug, has been developed. In order to get rid of the uncertainty associated with the infiltration of the cables through the plug a wireless data transmission system, based on acoustic waves, has been developed

  18. Bipolar magnetic semiconductor in silicene nanoribbons

    Energy Technology Data Exchange (ETDEWEB)

    Farghadan, Rouhollah, E-mail: rfarghadan@kashanu.ac.ir

    2017-08-01

    Highlights: • A new electronic phase for silicene nanoribbon in the presence of electric and magnetic fields. • Bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps in silicene. • Robust bipolar magnetic semiconductor features in a rough silicene. • Perfect and reversible spin polarization in silicene nanoribbon junctions. - Abstract: A theoretical study was presented on generation of spin polarization in silicene nanoribbons using the single-band tight-binding approximation and the non-equilibrium Green’s function formalism. We focused on the effect of electric and exchange magnetic fields on the spin-filter capabilities of zigzag-edge silicene nanoribbons in the presence of the intrinsic spin-orbit interaction. The results show that a robust bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps can be obtained when exchange magnetic and electric field strengths are both larger than the intrinsic spin-orbit interaction. Therefore, zigzag silicene nanoribbons could act as bipolar and perfect spin filter devices with a large spin-polarized current and a reversible spin polarization in the vicinity of the Fermi energy. We also investigated the effect of edge roughness and found that the bipolar magnetic semiconductor features are robust against edge disorder in silicene nanoribbon junctions. These results may be useful in multifunctional spin devices based on silicene nanoribbons.

  19. Family History in Patients with Bipolar Disorder.

    Science.gov (United States)

    Özdemir, Osman; Coşkun, Salih; Aktan Mutlu, Elif; Özdemir, Pınar Güzel; Atli, Abdullah; Yilmaz, Ekrem; Keskin, Sıddık

    2016-09-01

    In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients. Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital. Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother's or father's side, similar results were obtained: 25 patients were from the mother's side and 25 patients were from the father's side in 63 cases. The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility.

  20. [Drug Abuse Comorbidity in Bipolar Disorder].

    Science.gov (United States)

    Ortiz, Óscar Medina

    2012-06-01

    Drug use among patients with bipolar disorder is greater than the one observed in the general population; psychotic episodes are likely to occur after consumption. This has implications in the prevention, etiology, management, and treatment of the disease. Bipolar disorder pathology is likely to have positive response to pharmacological treatment. Therefore, identifying the strategies with better results to be applied in these patients is fundamental for psychiatrists and primary care physicians. Review literature in order to determine the prevalence and characteristics of drug abuse in patients with bipolar disorder and establish the pharmacological strategies that have produced better results. Literature review. A great variety of studies demonstrate the relationship between bipolar disorder and drug use disorder. These patients are hospitalized more frequently, have an earlier onset of the disease, and present a larger number of depressive episodes and suicide attempts which affect the course of the disease. The drug with better results in the treatment of these patients is Divalproate. Satisfactory results have been also obtained with other mood stabilizers such as carbamazepine, lamotrigine, and the antipsychotic aripiprazole. Substance abuse is present in a large number of patients with bipolar disorder. The Divalproate is the drug that has shown better results in the studies. Copyright © 2012 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  1. Bipolar magnetic semiconductor in silicene nanoribbons

    International Nuclear Information System (INIS)

    Farghadan, Rouhollah

    2017-01-01

    Highlights: • A new electronic phase for silicene nanoribbon in the presence of electric and magnetic fields. • Bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps in silicene. • Robust bipolar magnetic semiconductor features in a rough silicene. • Perfect and reversible spin polarization in silicene nanoribbon junctions. - Abstract: A theoretical study was presented on generation of spin polarization in silicene nanoribbons using the single-band tight-binding approximation and the non-equilibrium Green’s function formalism. We focused on the effect of electric and exchange magnetic fields on the spin-filter capabilities of zigzag-edge silicene nanoribbons in the presence of the intrinsic spin-orbit interaction. The results show that a robust bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps can be obtained when exchange magnetic and electric field strengths are both larger than the intrinsic spin-orbit interaction. Therefore, zigzag silicene nanoribbons could act as bipolar and perfect spin filter devices with a large spin-polarized current and a reversible spin polarization in the vicinity of the Fermi energy. We also investigated the effect of edge roughness and found that the bipolar magnetic semiconductor features are robust against edge disorder in silicene nanoribbon junctions. These results may be useful in multifunctional spin devices based on silicene nanoribbons.

  2. Comorbid medical illness in bipolar disorder.

    Science.gov (United States)

    Forty, Liz; Ulanova, Anna; Jones, Lisa; Jones, Ian; Gordon-Smith, Katherine; Fraser, Christine; Farmer, Anne; McGuffin, Peter; Lewis, Cathryn M; Hosang, Georgina M; Rivera, Margarita; Craddock, Nick

    2014-12-01

    Individuals with a mental health disorder appear to be at increased risk of medical illness. To examine rates of medical illnesses in patients with bipolar disorder (n = 1720) and to examine the clinical course of the bipolar illness according to lifetime medical illness burden. Participants recruited within the UK were asked about the lifetime occurrence of 20 medical illnesses, interviewed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and diagnosed according to DSM-IV criteria. We found significantly increased rates of several medical illnesses in our bipolar sample. A high medical illness burden was associated with a history of anxiety disorder, rapid cycling mood episodes, suicide attempts and mood episodes with a typically acute onset. Bipolar disorder is associated with high rates of medical illness. This comorbidity needs to be taken into account by services in order to improve outcomes for patients with bipolar disorder and also in research investigating the aetiology of affective disorder where shared biological pathways may play a role. Royal College of Psychiatrists.

  3. Soft tissue integration versus early biofilm formation on different dental implant materials

    NARCIS (Netherlands)

    Zhao, Bingran; van der Mei, Henderina; Subbiahdoss, Guruprakash; de Vries, Joop; Rustema-Abbing, Minie; Kuijer, Roel; Busscher, Henk J.; Qu-Ren, Yijin

    OBJECTIVE: Dental implants anchor in bone through a tight fit and osseo-integratable properties of the implant surfaces, while a protective soft tissue seal around the implants neck is needed to prevent bacterial destruction of the bone-implant interface. This tissue seal needs to form in the

  4. Rumination in bipolar disorder: evidence for an unquiet mind

    OpenAIRE

    Ghaznavi, Sharmin; Deckersbach, Thilo

    2012-01-01

    Abstract Depression in bipolar disorder has long been thought to be a state characterized by mental inactivity. However, recent research demonstrates that patients with bipolar disorder engage in rumination, a form of self-focused repetitive cognitive activity, in depressed as well as in manic states. While rumination has long been associated with depressed states in major depressive disorder, the finding that patients with bipolar disorder ruminate in manic states is unique to bipolar disord...

  5. Voltage regulator for battery power source. [using a bipolar transistor

    Science.gov (United States)

    Black, J. M. (Inventor)

    1979-01-01

    A bipolar transistor in series with the battery as the control element also in series with a zener diode and a resistor is used to maintain a predetermined voltage until the battery voltage decays to very nearly the predetermined voltage. A field effect transistor between the base of the bipolar transistor and a junction between the zener diode and resistor regulates base current of the bipolar transistor, thereby regulating the conductivity of the bipolar transistor for control of the output voltage.

  6. Design and development of face seal type sealing plug for advanced heavy water reactor

    International Nuclear Information System (INIS)

    Bansal, S.; Bhattacharyya, S.; Patel, R.J.; Agrawal, R.G.; Vaze, K.K.

    2005-09-01

    Advanced Heavy Water Reactor is a vertical pressure tube type reactor having light water as its coolant and heavy water as moderator. Sealing plug is required to close the pressure boundary of main heat transport system of the reactor by preventing escape of light water/steam From the coolant channel. There are 452 coolant channels in the reactor located in square lattice pitch. Sealing plug is located at the top of each coolant channel (in the top end fitting). Top end fitting is having a stepped bore to create a sealing face. Sealing plug is held through its expanded jaws in a specially provided groove of the end fitting. The plug was designed and prototypes were manufactured considering its functional importance, intricate design and precision machining requirements. Sealing plug consists of about 20 components mostly made up of precipitation hardening stainless steel, which is suitable for water environment and meets other requirements of strength and resistance to wear and galling. Seal disc is a critical component of the sealing plug as it is the pressure-retaining component. It is a circular disc with protruded stem. One face of the seal disc is nickel plated in the peripheral area that creates the sealing by abutting against the sealing face provided in the end fitting. The typical shape and profile of seal disc provides flexibility and allows elastic deformation to assist in locking of sealing plug and creating adequate seating force for effective sealing. Design and development aspects of the sealing plug have been detailed out in this report. Also results of stress analysis and experimental studies for seal disc have been mentioned in the report. Stress analysis and experimental testing was required for the seal disc because high stresses are developed due to its exposure to high pressure and temperature environment of Main Heat Transport system. Hot testing was carried out to simulate the reactor-simulated condition. The performance was found to be

  7. Numerical Investigation of the Effect of Radial Lip Seal Geometry on Sealing Performance

    Science.gov (United States)

    Tok, G.; Parlar, Z.; Temiz, V.

    2018-01-01

    Sealing elements are often needed in industry and especially in machine design. With the change and development of machine technology from day to day, sealing elements show continuous development and change in parallel with these developments. Many factors influence the performance of the sealing elements such as shaft surface roughness, radial force, lip geometry etc. In addition, the radial lip seals must have a certain pre-load and interference in order to provide a good sealing. This also affects the friction torque. Researchers are developing new seal designs to reduce friction losses in mechanical systems. In the presented study, the effect of the lip seal geometry on sealing performance will be examined numerically. The numerical model created for this purpose will be verified with experimental data firstly. In the numerical model, shaft and seal will be modeled as hyper-elastic in 2D and 3D. NBR (Nitrile Butadiene Rubber) as seal material will be analyzed for the rotating shaft state at constant speed by applying a uniform radial force.

  8. Actively controlled shaft seals for aerospace applications

    Science.gov (United States)

    Salant, Richard F.

    The objective of years 4 and 5 of this project (1992 and 1993) is to determine experimentally the behavior and operating characteristics of a controllable mechanical seal, and to identify potential problem areas. A controllable mechanical seal is one in which the thickness of the lubricating film separating the sealing surfaces is adjustable, and can be controlled by an electronic control system, based on information supplied by sensors that monitor the condition of the film. This work builds upon work done during years 1-3, in which a controllable mechanical seal was designed, analyzed, and fabricated. At the beginning of year 4, the mechanical seal and test rig was assembled, and preliminary testing begun. The five major tasks of years 4 and 5 encompass instrumentation, configuration changes of the mechanical seal to optimize its performance, systematic steady state tests, systematic transient tests, and a final report. During this reporting period, significant progress was made on instrumenting the test rig and modifying the design to optimize the seal's performance. Initial steady state tests were also performed.

  9. Family Functioning and the Course of Adolescent Bipolar Disorder

    Science.gov (United States)

    Sullivan, Aimee E.; Judd, Charles M.; Axelson, David A.; Miklowitz, David J.

    2012-01-01

    The symptoms of bipolar disorder affect and are affected by the functioning of family environments. Little is known, however, about the stability of family functioning among youth with bipolar disorder as they cycle in and out of mood episodes. This study examined family functioning and its relationship to symptoms of adolescent bipolar disorder,…

  10. Coping and personality in older patients with bipolar disorder

    NARCIS (Netherlands)

    Schouws, S.N.T.M.; Paans, N.P.G.; Comijs, H.C.; Dols, A.; Stek, M.L.

    2015-01-01

    Abstract Background Little is known about coping styles and personality traits in older bipolar patients. Adult bipolar patients show a passive coping style and higher neuroticism scores compared to the general population. Our aim is to investigate personality traits and coping in older bipolar

  11. Dealing with bipolar disorder in general practice | Rodseth | South ...

    African Journals Online (AJOL)

    ... it is in the general realm of specialist diagnosis and care, general practitioners can play an important role in early identification of the disorder and long-term management, in shared care with the psychiatrist. Keywords: bipolar disorder, mania, hypomania, depression, DSM-IV criteria, bipolar I disorder, bipolar II disorder ...

  12. Tamper-indicating quantum optical seals

    Energy Technology Data Exchange (ETDEWEB)

    Humble, Travis S [ORNL; Williams, Brian P [ORNL

    2015-01-01

    Confidence in the means for identifying when tampering occurs is critical for containment and surveillance technologies. Fiber-optic seals have proven especially useful for actively surveying large areas or inventories due to the extended transmission range and flexible layout of fiber. However, it is reasonable to suspect that an intruder could tamper with a fiber-optic sensor by accurately replicating the light transmitted through the fiber. In this contribution, we demonstrate a novel approach to using fiber-optic seals for safeguarding large-scale inventories with increased confidence in the state of the seal. Our approach is based on the use of quantum mechanical phenomena to offer unprecedented surety in the authentication of the seal state. In particular, we show how quantum entangled photons can be used to monitor the integrity of a fiber-optic cable - the entangled photons serve as active sensing elements whose non-local correlations indicate normal seal operation. Moreover, we prove using the quantum no-cloning theorem that attacks against the quantum seal necessarily disturb its state and that these disturbances are immediately detected. Our quantum approach to seal authentication is based on physical principles alone and does not require the use of secret or proprietary information to ensure proper operation. We demonstrate an implementation of the quantum seal using a pair of entangled photons and we summarize our experimental results including the probability of detecting intrusions and the overall stability of the system design. We conclude by discussing the use of both free-space and fiber-based quantum seals for surveying large areas and inventories.

  13. Surgical endodontic therapy: retrofilling of apex with amalgam and SuperSeal. Retrospective study.

    Science.gov (United States)

    Pljevljak, N; Minasi, R; Brauner, E; Galli, M

    2011-06-01

    The aim of this study was to make a retrospective analysis on teeth with apicectomized roots, closed off by retrograde with amalgam and SuperSeal-Ogna® (cement oxide of zinc and eugenol modified by acidity ethoxy-benzoic acid), in order to achieve clinical evaluation and radiographic evidence of treated dental elements and surrounding tissue SuperSeal (Ogna®). The study was conducted on 420 teeth, single and multi rooted, pertaining to 366 patients (189 women and 177 men) endodontically treated, in between 1998 and 2007. The teeth were treated with endodontic technique step-back and closed off with gutta-percha. Following the roots were apicectomyzed and then was prepared a retrograde cavity using retrotip steel mounted on the ultrasonic device. After carrying out the retrograde cavity all the samples were divided into two groups . The retrograde filling in Group A was made in Superseal, group B with amalgama. Both groups were divided in those teeths who was treated with use of optical microscope and in groups of teeths preformed without microscope. Nevertheless amalgam against the SuperSeal offers almost the same quality of the seal and the same prognosis. However SuperSeal as a material of choice, proved excellent, for carrying out the retrograde fillings free of some side effects, such as dimensional instability, mercury poisoning and pigmentation of tissues (tattoos from amalgam). In any case, whatever the type of material is, the operative microscope significantly affects the occurrence of failure. This demonstrates the importance of the microscope in order to obtain greater visibility and accuracy of the apex seal, more than minor sacrifice of healthy tissue.

  14. Concurrent hypokalemic periodic paralysis and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Chia-Lin Lin

    2015-01-01

    Full Text Available Primary periodic paralysis is a rare autosomal dominant disorder of ion-channel dysfunction, manifested by episodic flaccid paresis secondary to abnormal sarcolemma excitability. Membrane destabilization involving Na, K-ATPase has been hypothesized to be a biological etiology of the bipolar disorder (BD and the mechanisms underlying lithium therapy have been linked to it. To date, there has been only one reported case of BD comorbid with periodic paralysis. Herein, we reported another case of concurrent bipolar mania and hypokalemic periodic paralysis (HPP, one special form of periodic paralysis. Consistent with the previous case, our patient responded well to lithium treatment for both bipolar mania and HPP. This might provide some support to the hypothesis that the therapeutic effects of lithium in both BD and HPP could be due to the correction of the underlying common pathophysiology.

  15. Paired structures and bipolar knowledge representation

    DEFF Research Database (Denmark)

    Montero, Javier; Bustince, Humberto; Franco, Camilo

    In this strictly positional paper we propose a general approach to bipolar knowledge representation, where the meaning of concepts can be modelled by examining their decomposition into opposite and neutral categories. In particular, it is the semantic relationship between the opposite categories...... which suggests the emergence of a paired structure and its associated type of neutrality, being there three general types of neutral categories, namely indeterminacy, ambivalence and conflict. Hence, the key issue consists in identifying the semantic opposition characterizing the meaning of concepts...... and at the same time the type of neutrality rising in between opposites. Based on this first level of bipolar knowledge representation, paired structures in fact offer the means to characterize a specific bipolar valuation scale depending on the meaning of the concept that has to be verified. In this sense...

  16. Fenomenologia do tempo vivido no transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Virginia Moreira

    Full Text Available Com base na tradição da psicopatologia fenomenológica, este artigo se propõe a contribuir para a compreensão do mundo vivido do paciente bipolar, marcado por uma forte alteração do tempo vivido. Realizamos uma descrição deste tempo vivido significado de forma diferente nas oscilações de humor chamadas de fase maníaca e fase melancólica. Pensado a partir da temporalidade, na fase melancólica, o bipolar parece parar no tempo, não se lança em um devir. Na fase maníaca, o sujeito vive demasiadamente um agora como se tivesse explodido sua biografia. Concluímos que estas fases, ou dois pólos opostos no funcionamento temporal patológico do sofrimento bipolar, constituem fundamentalmente um mesmo mundo vivido.

  17. Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder.

    Science.gov (United States)

    Hare, Elizabeth; Contreras, Javier; Raventos, Henriette; Flores, Deborah; Jerez, Alvaro; Nicolini, Humberto; Ontiveros, Alfonso; Almasy, Laura; Escamilla, Michael

    2012-02-01

    Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I), the intermediate phenotype (schizoaffective bipolar, bipolar I, and bipolar II), and the broadest phenotype (schizoaffective bipolar, bipolar I, bipolar II, and recurrent depression), respectively. For the Big Five personality factors, heritabilities were 0.25 for agreeableness, 0.24 for conscientiousness, 0.24 for extraversion, 0.23 for neuroticism, and 0.32 for openness to experience. For the narrowest phenotype, a significant negative correlation (-0.32) with extraversion was found. For the broadest phenotype, negative correlations were found for agreeableness (-0.35), conscientiousness (-0.39), and extraversion (-0.44). A positive correlation (0.37) was found with neuroticism. It is not possible to determine whether aspects of personality are factors in the development of bipolar disorder or vice versa. The short form of the NEO does not provide the ability to examine in detail which facets of extraversion are most closely related to bipolar disorder or to compare our results with studies that have used the long version of the scale. This study establishes a partial genetic basis for the Big Five personality factors in this set of families, while the environmental variances demonstrate that non-genetic factors are also important in their influence on

  18. Systematic review of the prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies

    OpenAIRE

    Dell'Aglio Jr.,José Caetano; Basso,Lissia Ana; Argimon,Irani Iracema de Lima; Arteche,Adriane

    2013-01-01

    This paper describes the findings of a systematic literature review aimed at providing an overview of the lifetime prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies. Databases MEDLINE, ProQuest, Psychnet, and Web of Science were browsed for papers published in English between 1999 and May 2012 using the following search string: bipolar disorders OR bipolar spectrum disorders AND prevalence OR cross-sectional OR epidemiology AND population-based OR non-c...

  19. Prototypes of phosphorus-32 sealed sources for use in Brachytherapy

    International Nuclear Information System (INIS)

    Anaya Garro, Olgger; Vela Mora, Mariano; Revilla Silva, Angel Revilla

    2005-01-01

    It has developed prototypes of phosphorus-32 sealed sources for use in Brachytherapy. This one was made in two stages, at the first one, we designed and constructed the container (capsule), the filling system and the sealed system; at the second one, we made the irradiation of the capsules containing the 'target'. The prototypes was made of aluminum in cylindrical geometry. During the irradiation test was made using two different dimensions: one of 1 mm outer diameter and 1 cm length and another one of 0.8 mm outer diameter and 5 mm length. They were radiated in the core of the RP-10 research reactor, at 7.93 x10 13 n/cm 2 .s thermal neutron flux during 27 operation cycles. Activities of 144.53 MBq (3.91 mCi) and 107.67 MBq (2.91 mCi) was obtained for each case. This activities are adequate to restenosis and for some tumors treatment. We can observed that the capsules irradiated passed visual inspection in its physical integrity (leakage and geometry). It has been demonstrated, that the beta radiation for his minor power of penetration and its high interaction, causes major local damage to the malignant tissue, minimizing the damage of the healthy surrounding tissues. It has been advisable to use for the treatment of illnesses of the circulatory system and some tumors. At the present, the source of strontium-90 are the most beta ray source used, but of this one are obtained as fission product of uranium target, where valuable radioactive waste is generated, whereas if we were using phosphorus-32 that we propose, radioactive waste would not be generated since it would take place directly as sealed source, for reaction (n, β). (author)

  20. Compliant Glass Seals for SOFC Stacks

    Energy Technology Data Exchange (ETDEWEB)

    Chou, Yeong -Shyung [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Choi, Jung-Pyung [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Xu, Wei [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stephens, Elizabeth V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Koeppel, Brian J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stevenson, Jeffry W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lara-Curzio, Edgar [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-04-30

    This report summarizes results from experimental and modeling studies performed by participants in the Solid-State Energy Conversion Alliance (SECA) Core Technology Program, which indicate that compliant glass-based seals offer a number of potential advantages over conventional seals based on de-vitrifying glasses, including reduced stresses during stack operation and thermal cycling, and the ability to heal micro-damage induced during thermal cycling. The properties and composition of glasses developed and/or investigated in these studies are reported, along with results from long-term (up to 5,800h) evaluations of seals based on a compliant glass containing ceramic particles or ceramic fibers.

  1. Infiltrating/sealing proximal caries lesions

    DEFF Research Database (Denmark)

    Martignon, S; Ekstrand, K R; Gomez, J

    2012-01-01

    This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3...... differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference...

  2. Spraying for time - Abradable seals the key

    Science.gov (United States)

    Haines, S. A.

    1984-03-01

    Abradable seals are explained and a brief history of their development is given. Abradable seals are made of high-temperature-resistant composite powders, such as nickel-coated graphite, that constitute a core material coated with metal. They must abrade easily if struck by turbine blades and be soft enough to prevent engine damage should they be blown back. Research done to improve abradable seals with respect to hardness, oxidation, resistance and temperature changes is stressed. The end result is a composite powder with good insulating properties and the ability to withstand temperatures up to 850 C.

  3. Exercise in bipolar patients: A systematic review.

    Science.gov (United States)

    Melo, Matias Carvalho Aguiar; Daher, Elizabeth De Francesco; Albuquerque, Saulo Giovanni Castor; de Bruin, Veralice Meireles Sales

    2016-07-01

    Sedentary lifestyle is frequent in psychiatric disorders, however the directions of this association and benefits of physical activity are unclear. This is a systematic review about exercise in patients with bipolar disorder. We performed a systematic literature search of studies published in English (1995 Jan to 2016 Jan) in PubMed, and Cochrane Library combining the medical terms 'physical activity' or 'sedentary' or 'physical exercise' with 'bipolar disorder' or 'mania' or 'bipolar depression'. Thirty-one studies were selected and included 15,587 patients with bipolar disorder. Sedentary lifestyle varied from 40% to 64.9%. Physical activity was associated with less depressive symptoms, better quality of life and increased functioning. Some evidence indicates a relationship between vigorous exercises and mania. Three prospective cohorts were reported; and no prospective randomized controlled trial was identified. Three studies focused on biomarkers in bipolar patients; and one reported the relationship between exercise and sleep in this group. Two assessed physical exercise in adolescents. (1) Differences between studies preventing a unified analysis; (2) most studies were cross-sectional; (3) motivation for exercising is a selection bias in most studies; (4) no intervention study assessing only physical exercise; (5) lack of studies comparing exercise across mood states. Generally, exercise was associated with improved health measures including depressive symptoms, functioning and quality of life. Evidence was insufficient to establish a cause-effect relationship between mood and physical exercise. Future research including randomized trials is needed to clarify the role of physical activity in bipolar patients. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Fibromyalgia and bipolar disorder: extent of comorbidity and therapeutic implications.

    Science.gov (United States)

    Di Tommaso Morrison, M C; Carinci, F; Lessiani, G; Spinas, E; Kritas, S K; Ronconi, G; Caraffa, Al; Conti, P

    2017-01-01

    Fibromyalgia (FM) is a syndrome that affects muscles and soft tissues. Presenting symptoms include chronic muscle pain, fatigue, sleep problems and psychological symptoms, including depression and anxiety. There exists strong evidence of a comorbidity between FM and Bipolar Disorder (BD). In this study, papers from 2006 to February 2016 that examined the comorbidity and etiological similarities of FM and BD were reviewed, as well as the therapeutic implications of these findings. The reviewed articles showed that an adequate psychiatric screening for BD is recommended in FM patients with depressive symptoms, in order to decrease administration of antidepressants for BD, due to the lack of proven efficacy, and to limit antidepressant-induced mania. Alternative therapies, such as agomelatine, memantine and psychotherapic treatment should be considered.

  5. A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force

    DEFF Research Database (Denmark)

    Sajatovic, Martha; Strejilevich, Sergio A; Gildengers, Ariel G

    2015-01-01

    OBJECTIVES: In the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD). METHO...

  6. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder

    NARCIS (Netherlands)

    Kupka, Ralph W.; Altshuler, Lori L.; Nolen, Willem A.; Suppes, Trisha; Luckenbaugh, David A.; Leverich, Gabriele S.; Frye, Mark A.; Keck, Paul E.; McElroy, Susan L.; Grunze, Heinz; Post, Robert M.

    Objectives: To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder. Methods: Clinician-adjusted self-ratings of mood were

  7. Alcoholism and anxiety in bipolar illness : Differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism

    NARCIS (Netherlands)

    Levander, Eric; Frye, Mark A.; McElroy, Susan; Suppes, Trisha; Grunze, Heinz; Nolen, Willem A.; Kupka, Ralph; Keck, Paul E.; Leverich, Gabriele S.; Altshuler, Lori L.; Hwang, Sun; Mintz, Jim; Post, Robert M.

    Introduction: This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD). Methods: Bipolar men and women who entered the Stanley Foundation Bipolar Network (SFBN) underwent a Structured Clinical Interview for

  8. Fabrication of Sealed Nanostraw Microdevices for Oral Drug Delivery.

    Science.gov (United States)

    Fox, Cade B; Cao, Yuhong; Nemeth, Cameron L; Chirra, Hariharasudhan D; Chevalier, Rachel W; Xu, Alexander M; Melosh, Nicholas A; Desai, Tejal A

    2016-06-28

    The oral route is preferred for systemic drug administration and provides direct access to diseased tissue of the gastrointestinal (GI) tract. However, many drugs have poor absorption upon oral administration due to damaging enzymatic and pH conditions, mucus and cellular permeation barriers, and limited time for drug dissolution. To overcome these limitations and enhance oral drug absorption, micron-scale devices with planar, asymmetric geometries, termed microdevices, have been designed to adhere to the lining of the GI tract and release drug at high concentrations directly toward GI epithelium. Here we seal microdevices with nanostraw membranes-porous nanostructured biomolecule delivery substrates-to enhance the properties of these devices. We demonstrate that the nanostraws facilitate facile drug loading and tunable drug release, limit the influx of external molecules into the sealed drug reservoir, and increase the adhesion of devices to epithelial tissue. These findings highlight the potential of nanostraw microdevices to enhance the oral absorption of a wide range of therapeutics by binding to the lining of the GI tract, providing prolonged and proximal drug release, and reducing the exposure of their payload to drug-degrading biomolecules.

  9. 19 CFR 123.24 - Sealing of conveyances or compartments.

    Science.gov (United States)

    2010-04-01

    ...; DEPARTMENT OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO Shipments in Transit Through Canada or Mexico § 123.24 Sealing of conveyances or compartments. (a) Sealing required. Merchandise in transit...-bound seals may go forward without additional seals. (c) Carrier relieved of responsibility. The port...

  10. Sealing and monitoring a container containing heat generating materials

    International Nuclear Information System (INIS)

    Bourrelly, P.; Monier, J.; Parin, H.; Sanson, C.; Schoepp, R.

    1986-01-01

    The sealing system includes one or several seals on the container wall. These seals comprise resistors electrically connected and thermally insulated for monitoring heat transfer between the seal and the container or the environment by producing an electric signal to a remote monitor. Opening the container changes the heat flux which is detected. Application is made for monitoring radioactive waste containers [fr

  11. The southern elephant seal Mirounga leonina at Gough Island

    African Journals Online (AJOL)

    haul-out in December coincided with the elephant seal moulting season, the elephant seals were found on the vegetated areas whilst the majority of fur seals hauled out onto the boulder beach. No interactions between the two species were recorded. Potential predators of elephant seals, i.e. the killer whales Orcinus orca ...

  12. Application of radioisotope technique for investigation of pumps seals

    International Nuclear Information System (INIS)

    Antoszewski, B.; Zorawska, A.

    1988-01-01

    Radioisotope method of measuring the wear of rings of the face mechanical seals, bush in soft seals, and leakage in double mechanical seals is described. The examples are given. It is found that radioisotope technique can be used for investigation of the seals. (author)

  13. A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder

    Science.gov (United States)

    Sellgren, CM; Kegel, ME; Bergen, SE; Ekman, CJ; Olsson, S; Larsson, M; Vawter, MP; Backlund, L; Sullivan, PF; Sklar, P; Smoller, JW; Magnusson, PKE; Hultman, CM; Walther-Jallow, L; Svensson, CI; Lichtenstein, P; Schalling, M; Engberg, G; Erhardt, S; Landén, M

    2016-01-01

    Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we conducted a genome-wide association study based on CSF KYNA in bipolar disorder and found support for an association with a common variant within 1p21.3. After replication in an independent cohort, we linked this genetic variant—associated with reduced SNX7 expression—to positive psychotic symptoms and executive function deficits in bipolar disorder. A series of post-mortem brain tissue and in vitro experiments suggested SNX7 downregulation to result in a caspase-8-driven activation of interleukin-1β and a subsequent induction of the brain kynurenine pathway. The current study demonstrates the potential of using biomarkers in genetic studies of psychiatric disorders, and may help to identify novel drug targets in bipolar disorder. PMID:23459468

  14. HMSRP Hawaiian Monk Seal Necropsy Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains information on Hawaiian monk seal gross necropsy (in some cases only field notes or minimal information) and histopathology results beginning...

  15. HMSRP Hawaiian Monk Seal Survival Factors

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains records of survival factors recorded by PSD personnel and cooperating scientists as part of the ongoing monk seal population assessment...

  16. HMSRP Hawaiian Monk Seal Microsatellite Genotypes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Currently ~2,400 Hawaiian monk seal specimens have been analyzed genetically, providing genotypes at 18 microsatellite loci. These data are organized by individual,...

  17. Onboard Acoustic Recording from Diving Elephant Seals

    National Research Council Canada - National Science Library

    Fletcher, Stacia

    1996-01-01

    The aim of this project was to record sounds impinging on free-ranging northern elephant seals, Mirounga angustirostris, a first step in determining the importance of LFS to these animals as they dive...

  18. Cask systems development program seal technology

    International Nuclear Information System (INIS)

    Madsen, M.M.; Humphreys, D.L.; Edwards, K.R.

    1991-01-01

    General design or test performance requirements for radioactive materials (RAM) packages are specified in Title 10 of the US Code of Federal Regulations Part 71 (10 CFR 71). Seals that provide the containment system interface between the packaging body and the closure must function in both high- and low-temperature environments under dynamic and static conditions. Experiments were performed to characterize the performance of several seal materials at low temperatures. Helium leak tests on face seals were used to compare the materials. Materials tested include butyl, neoprene, ethylene propylene, fluorosilicone, silicone, Eypel, Kalrez, Teflon, fluorocarbon, and Teflon/silicone composites. Results show that the seal materials tested, with the exception of silicone S613-60, are not leak tight (1 x 10 -7 std cm 3 /s) at manufacturer low-temperature ratings

  19. Fuel cell cassette with compliant seal

    Science.gov (United States)

    Karl, Haltiner, Jr. J.; Anthony, Derose J.; Klotzbach, Darasack C.; Schneider, Jonathan R.

    2017-11-07

    A fuel cell cassette for forming a fuel cell stack along a fuel cell axis includes a cell retainer, a plate positioned axially to the cell retainer and defining a space axially with the cell retainer, and a fuel cell having an anode layer and a cathode layer separated by an electrolyte layer. The outer perimeter of the fuel cell is positioned in the space between the plate and the cell retainer, thereby retaining the fuel cell and defining a cavity between the cell retainer, the fuel cell, and the plate. The fuel cell cassette also includes a seal disposed within the cavity for sealing the edge of the fuel cell. The seal is compliant at operational temperatures of the fuel cell, thereby allowing lateral expansion and contraction of the fuel cell within the cavity while maintaining sealing at the edge of the fuel cell.

  20. Prevention of Stripping under Chip Seals

    Science.gov (United States)

    2017-10-01

    Eighteen chip-sealed roadways in eight cities and counties in Minnesota were evaluated both in the field (for condition surveys and density tests) and in the laboratory (for permeability, stripping, tensile-strength ratio, asphalt film thickness, and...

  1. Chip seal performance measures : best practices.

    Science.gov (United States)

    2015-03-01

    The Washington State Department of Transportation (WSDOT) has a long history of designing, constructing, : and maintaining chip seal or bituminous surface treatment pavements. However, to date WSDOT has not : developed pavement performance indicators...

  2. Sealing And Filling Cracks In Asphalt Pavements

    Science.gov (United States)

    1999-11-01

    The primary objective of the crack treatment experiment was to determine the most effective and economical materials and methods for conducting crack-sealing and crack-filling operations. Secondary objectives included the identification of performanc...

  3. Epoxy resins used to seal brachytherapy seed

    International Nuclear Information System (INIS)

    Ferreira, Natalia Carolina Camargos; Ferraz, Wilmar Barbosa; Reis, Sergio Carneiro dos; Santos, Ana Maria Matildes dos

    2013-01-01

    Prostate cancer treatment with brachytherapy is recommended for patients with cancer at an early stage. In this treatment, small radioactive seeds are implanted directly in the prostate gland. These seeds are composed at least of one radionuclide carrier and an X-ray marker enclosed within a metallic tube usually sealed by laser process. This process is expensive and, furthermore, it can provoke a partial volatilization of the radionuclide and change the isotropy in dose distribution around the seed. In this paper, we present a new sealing process using epoxy resin. Three kinds of resins were utilized and characterized by scanning electron microscopy (SEM), energy dispersive X ray (EDS) and by differential scanning calorimetry (DSC) after immersion in simulated body fluid (SBF) and in sodium iodine solution (NaI). The sealing process showed excellent potential to replace the sealing laser usually employed. (author)

  4. Management of spent sealed sources in Indonesia

    International Nuclear Information System (INIS)

    Wisnubroto, D.S.

    2002-01-01

    This paper describes the effort of the Center for Development of Radioactive Waste Management (CDRWM) to develop and implement activities in maintaining and improving the safety of spent sealed radiation sources and the security of radioactive materials over their life cycle. There is a wide variety of uses of radiation sources and radioactive materials in Indonesia, while the CDRWM plan to cover all spent radiation sources. Primary consideration is given to sealed radiation sources with relatively high levels of radioactivity which might necessitate interventional measures should control over them be lost. The policy of the Government of Indonesia for spent radiation sources is, whenever possible, spent sealed sources should be returned to the supplier. CDRWM has a general principle that sealed sources should not be removed from their holders, or the holders physically modified (except for Ra-226 needles, smoke detector and lighting preventer). (author)

  5. Inflatable Module Seal Interface Development and Testing

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop a repeatable low permeable sealing interface evaluating O-ring, RTV bond and flowed RTV bond methods. Advanced Bladder materials (ArmorFlex, Nanoclay, etc)...

  6. HMSRP Hawaiian Monk Seal Tag Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains records for all tags applied to Hawaiian monk seals since 1981. These tags were applied by PSD personnel and cooperating scientists as part of...

  7. Rotatable seal assembly. [Patent application; rotating targets

    Science.gov (United States)

    Logan, C.M.; Garibaldi, J.L.

    1980-11-12

    An assembly is provided for rotatably supporting a rotor on a stator so that vacuum chambers in the rotor and stator remain in communication while the chambers are sealed from ambient air, which enables the use of a ball bearing or the like to support most of the weight of the rotor. The apparatus includes a seal device mounted on the rotor to rotate therewith, but shiftable in position on the rotor while being sealed to the rotor as by an O-ring. The seal device has a flat face that is biased towards a flat face on the stator, and pressurized air is pumped between the faces to prevent contact between them while spacing them a small distance apart to avoid the inflow of large amounts of air between the faces and into the vacuum chambers.

  8. Diverse papillomaviruses identified in Weddell seals.

    Science.gov (United States)

    Smeele, Zoe E; Burns, Jennifer M; Van Doorsaler, Koenraad; Fontenele, Rafaela S; Waits, Kara; Stainton, Daisy; Shero, Michelle R; Beltran, Roxanne S; Kirkham, Amy L; Berngartt, Rachel; Kraberger, Simona; Varsani, Arvind

    2018-04-01

    Papillomaviridae is a diverse family of circular, double-stranded DNA (dsDNA) viruses that infect a broad range of mammalian, avian and fish hosts. While papillomaviruses have been characterized most extensively in humans, the study of non-human papillomaviruses has contributed greatly to our understanding of their pathogenicity and evolution. Using high-throughput sequencing approaches, we identified 7 novel papillomaviruses from vaginal swabs collected from 81 adult female Weddell seals (Leptonychotes weddellii) in the Ross Sea of Antarctica between 2014-2017. These seven papillomavirus genomes were amplified from seven individual seals, and six of the seven genomes represented novel species with distinct evolutionary lineages. This highlights the diversity of papillomaviruses among the relatively small number of Weddell seal samples tested. Viruses associated with large vertebrates are poorly studied in Antarctica, and this study adds information about papillomaviruses associated with Weddell seals and contributes to our understanding of the evolutionary history of papillomaviruses.

  9. Multi-Canister overpack sealing configuration

    International Nuclear Information System (INIS)

    SMITH, K.E.

    1998-01-01

    The Spent Nuclear Fuel (SNF) position regarding the Multi-Canister Overpack (MCO) sealing configuration is to initially rely on an American Society of Mechanical Engineers (ASME) Section III Subsection NB code compliant mechanical closure/sealing system to quickly and safely establish and maintain full confinement of radioactive materials prior to and during MCO fuel drying activities. Previous studies have shown the mechanical seal to be the preferred closure method, based on dose, cost, and schedule considerations. The cost and schedule impacts of redesigning the mechanical closure to a welded shield plug do not support changing the closure system. The SNF Project has determined that the combined mechanical/welded closure system meets or exceeds the regulatory requirements to provide redundant seals while accommodating key safety and schedule limitations that are unique to K Basins fuel removal effort

  10. HMSRP Hawaiian Monk Seal Photo Identification Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This photo collection contains identification and other images and video of Hawaiian monk seals taken by PSD personnel and cooperating scientists as part of the...

  11. HMSRP Hawaiian Monk Seal Fisheries Interactions data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data set contains records of all documented hookings and/or entanglements of Hawaiian monk seals with actively fished gear, both commercial and recreational. The...

  12. HMSRP Hawaiian Monk Seals on Social Media

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — As social media platforms develop, they potentially provide valuable information for wildlife researchers and managers. NOAA’s Hawaiian Monk Seal Research Program...

  13. Collyria seals in the Roman Empire.

    Science.gov (United States)

    Perez-Cambrodi, Rafael J; Pinero, David P; Mavrou, Ariadni; Cervino, Alejandro; Brautaset, Rune; Murube del Castillo, Juan

    2013-01-01

    Roman seals associated with collyria (Latin expression for eye drops/washes and lotions for eye maintenance) provide valuable information about eye care in the antiquity. These small, usually stone-made pieces bore engravings with the names of eye doctors and also the collyria used to treat an eye disease. The collyria seals have been found all over the Roman empire and Celtic territories in particular and were usually associated with military camps. In Hispania (Iberian Peninsula), only three collyria seals have been found. These findings speak about eye care in this ancient Roman province as well as about of the life of the time. This article takes a look at the utility and social significance of the collyria seals and seeks to give an insight in the ophthalmological practice of in the Roman Empire.

  14. HMSRP Hawaiian Monk Seal Survey Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains records of Hawaiian monk seal and green turtle sightings in the Northwestern Hawaiian Islands (NWHI) since 1982 at Lisianski Island, and since...

  15. Transtorno afetivo bipolar: um enfoque transcultural Transcultural aspects of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Marsal Sanches

    2004-10-01

    Full Text Available Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.Cultural variations in the expression of emotions have been described. Consequently, there are cross-cultural influences on the diagnosis and management of bipolar disorder. This article provides a review of the evidence regarding the main aspects of transcultural psychiatry and bipolar disorder.

  16. Tamper-indicating devices and safeguards seals evaluation test report

    International Nuclear Information System (INIS)

    Horton, P.R.V.; Waddoups, I.G.

    1993-12-01

    Sandia National Laboratories was asked to evaluate the seals used as tamper-indicating devices (TIDs) at DOE facilities. Initially, a survey determined what seal manufacturers were being used and what similar seal types were available. Once the required specifications for TIDs were defined, a test plan measured the currently available seals against the requirements. Environmental and physical type tests stressed the seals under two broad categories: (1) handling durability and (2) tamper resistance. Results of the testing provide comparative ratings for the various seals, recommendations for using currently available seals, and a new tamper-indicating technology

  17. Troubleshooting ProSeal LMA

    Directory of Open Access Journals (Sweden)

    Bimla Sharma

    2009-01-01

    Full Text Available Supraglottic devices have changed the face of the airway management. These devices have contributed in a big way in airway management especially, in the difficult airway scenario significantly decreasing the pharyngolaryngeal morbidity. There is a plethora of these devices, which has been well matched by their wider acceptance in clinical practice. ProSeal laryngeal mask airway (PLMA is one such frequently used device employed for spontaneous as well as controlled ventilation. However, the use of PLMAat tunes maybe associated with certain problems. Some of the problems related with its use are unique while others are akin to the classic laryngeal mask airway (eLMA. However, expertise is needed for its safe and judicious use, correct placement, recognition and management of its various malpositions and complications. The present article describes the tests employed for proper confirmation of placementto assess the ventilatooy and the drain tube functions of the mask, diagnosis of various malpositions and the management of these aspects. All these areas have been highlighted under the heading of troubleshooting PLMA. Many problems can be solved by proper patient and procedure selection, maintaining adequate depth of anaesthesia, diagnosis and management of malpositions. Proper fixation of the device and monitoring cuff pressure intraopera-tively may bring down the incidence of airway morbidity.

  18. Simulation of leakage through mechanical sealing device

    Science.gov (United States)

    Tikhomorov, V. P.; Gorlenko, O. A.; Izmerov, M. A.

    2018-03-01

    The procedure of mathematical modeling of leakage through the mechanical seal taking into account waviness and roughness is considered. The percolation process is represented as the sum of leakages through a gap between wavy surfaces and percolation through gaps formed by fractal roughness, i.e. the total leakage is determined by the slot model and filtration leakage. Dependences of leaks on the contact pressure of corrugated and rough surfaces of the mechanical seal elements are presented.

  19. Mechanical seal having a double-tier mating ring

    Science.gov (United States)

    Khonsari, Michael M.; Somanchi, Anoop K.

    2005-09-13

    An apparatus and method to enhance the overall performance of mechanical seals in one of the following ways: by reducing seal face wear, by reducing the contact surface temperature, or by increasing the life span of mechanical seals. The apparatus is a mechanical seal (e.g., single mechanical seals, double mechanical seals, tandem mechanical seals, bellows, pusher mechanical seals, and all types of rotating and reciprocating machines) comprising a rotating ring and a double-tier mating ring. In a preferred embodiment, the double-tier mating ring comprises a first and a second stationary ring that together form an agitation-inducing, guided flow channel to allow for the removal of heat generated at the seal face of the mating ring by channeling a coolant entering the mating ring to a position adjacent to and in close proximity with the interior surface area of the seal face of the mating ring.

  20. BIPOLAR DISORDER AND METABOLIC SYNDROME: COMORBIDITY OR SIDE EFFECTS OF TREATMENT OF BIPOLAR DISORDER

    OpenAIRE

    Babić, Dragan; Maslov, Boris; Nikolić, Katica; Martinac, Marko; Uzun, Suzana; Kozumplik, Oliver

    2010-01-01

    Objective: There is evidence that people with mental disorders are more likely to suffer from metabolic syndrome. In the last decades there has been an increase in interest for researching metabolic syndrome in psychiatric patients and plenty of evidence about their association. However, investigations on the prevalence of metabolic syndrome in patients with bipolar disorder are still surprisingly rare. The aim of this paper is to analyze comorbidity of bipolar disorder and metabolic syndrome...

  1. Behaviour of elastomeric seals at low temperature

    International Nuclear Information System (INIS)

    Weise, H.P.; Kowalewsky, H.; Wenz, R.

    1993-01-01

    The properties of elastomer O-ring seals (Viton, silicone rubber, EPDM) at low temperature have been investigated by measuring the gas leakage rate and the sealing force during thermal cycling between +20degC and -70degC. For all materials it has been found that at a well defined (critical) temperature the leakage rate sharply rises from permeation level to a high value which is determined by gas streaming through the leak path between the O-ring and the flange surfaces arising from thermal contraction of the elastomer in the glassy state. At the critical temperature the sealing force has been found to be zero or even negative due to adhesion between the elastomer material and the flanges. For all seals the critical temperature is well below the glass transition of the elastomer and also significantly below the temperature where the compression set becomes 100 %. Warming up the sealing system restores leak tightness. Low temperature cycle of elastomeric seals have been found to be entirely reversible. (author)

  2. Self-balancing air riding seal for a turbine

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Jacob A.

    2017-08-15

    A turbine of a gas turbine engine has an air riding seal that forms a seal between a rotor and a stator of the turbine, the air riding seal including an annular piston movable in an axial direction under the influence of a pressure on one side with a pressure acting on an opposite side that self-balances the air riding seal during the steady state condition of the engine and lifts off the seal during engine transients.

  3. Unblending Borderline Personality and Bipolar Disorders.

    Science.gov (United States)

    di Giacomo, Ester; Aspesi, Flora; Fotiadou, Maria; Arntz, Arnoud; Aguglia, Eugenio; Barone, Lavinia; Bellino, Silvio; Carpiniello, Bernardo; Colmegna, Fabrizia; Lazzari, Marina; Lorettu, Liliana; Pinna, Federica; Sicaro, Aldo; Signorelli, Maria Salvina; Clerici, Massimo

    2017-08-01

    Borderline Personality (BPD) and Bipolar (BP) disorders stimulate an academic debate between their distinction and the inclusion of Borderline in the Bipolar spectrum. Opponents to this inclusion attribute the important differences and possible diagnostic incomprehension to overlapping symptoms. We tested 248 Borderline and 113 Bipolar patients, consecutively admitted to the Psychiatric Unit, through DSM-IV Axis I and II Disorders (SCID-I/II), Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Young Mania Rating Scale (YMRS) and Borderline Personality Disorder Severity Index-IV (BPDSI-IV). All the tests statistically discriminated the disorders (p Borderline patients with manic features offer a privileged point of view for a deeper analysis. This allows for the possibility of a more precise examination of the nature and load of each symptom. Borderline Personality and Bipolar Disorders can be distinguished with high precision using common and time-sparing tests. The importance of discriminating these clinical features may benefit from this evidence. Copyright © 2017. Published by Elsevier Ltd.

  4. Bipolar disorder: Evidence for a major locus

    Energy Technology Data Exchange (ETDEWEB)

    Spence, M.A.; Flodman, P.L. [Univ. of California, Irvine, CA (United States); Sadovnick, A.D.; Ameli, H. [Univ. of British Columbia, Vancouver (Canada)] [and others

    1995-10-09

    Complex segregation analyses were conducted on families of bipolar I and bipolar II probands to delineate the mode of inheritance. The probands were ascertained from consecutive referrals to the Mood Disorder Service, University Hospital, University of British Columbia and diagnosed by DSM-III-R and Research Diagnostic Criteria. Data were available on over 1,500 first-degree relatives of the 186 Caucasian probands. The purpose of the analyses was to determine if, after correcting for age and birth cohort, there was evidence for a single major locus. Five models were fit to the data using the statistical package SAGE: (1) dominant, (2) recessive, (3) arbitrary mendelian inheritance, (4) environmental, and (5) no major effects. A single dominant, mendelian major locus was the best fitting of these models for the sample of bipolar I and II probands when only bipolar relatives were defined as affected (polygenic inheritance could not be tested). Adding recurrent major depression to the diagnosis {open_quotes}affected{close_quotes} for relatives reduced the evidence for a major locus effect. Our findings support the undertaking of linkage studies and are consistent with the analyses of the National Institutes of Mental Health (NIMH) Collaborative Study data by Rice et al. and Blangero and Elston. 39 refs., 4 tabs.

  5. Comorbidity of bipolar disorder and eating disorders.

    Science.gov (United States)

    Álvarez Ruiz, Eva M; Gutiérrez-Rojas, Luis

    2015-01-01

    The comorbidity of bipolar disorder and eating disorders has not been studied in depth. In addition, clinical implications involved in the appearance of both disorders are very important. A systematic literature review of MEDLINE published up to September 2013 was performed, analyzing all the articles that studied the comorbidity of both conditions (bipolar disorder and eating disorders) and others research that studied the efficacy of pharmacological treatment and psychotherapy to improve these illnesses. In this review we found a high comorbidity of bipolar disorder and eating disorders, especially of bulimia nervosa and binge eating disorder. Studies show that lithium and topiramate are 2 of the more effective pharmacological agents in the treatment of both disorders. There are a lot of studies that show evidence of comorbidity of bipolar disorder and eating disorders. However, further research is needed on assessment and treatment when these conditions co-exist, as well as study into the biopsychological aspects to determine the comorbid aetiology. Copyright © 2014 SEP y SEPB. Published by Elsevier España. All rights reserved.

  6. Radiation Damage In Advanced Bipolar Transistors

    Science.gov (United States)

    Zoutendyk, John A.; Goben, Charles A.; Berndt, Dale F.

    1989-01-01

    Report describes measurements of common-emitter current gains (hFE) of advanced bipolar silicon transistors before, during, and after irradiation with 275-MeV bromine ions, 2.5-MeV electrons, and conductivity rays from cobalt-60 atoms.

  7. Facial affect recognition deficits in bipolar disorder.

    Science.gov (United States)

    Getz, Glen E; Shear, Paula K; Strakowski, Stephen M

    2003-05-01

    Patients diagnosed with bipolar disorder (BPD), by definition, have problems with emotional regulation. However, it remains uncertain whether these patients are also deficient at processing other people's emotions, particularly while manic. The present study examined the ability of 25 manic bipolar patients and 25 healthy participants on tasks of facial recognition and facial affect recognition at three different presentation durations: 500 ms, 750 ms, and 1000 ms. The groups did not differ in terms of age, education, sex, ethnicity, or estimated IQ. The groups did not differ significantly on either a novel computerized facial recognition task or the Benton Facial Recognition Test. In contrast, the bipolar group performed significantly more poorly than did the comparison group on a novel facial affect labeling task. Although the patient group had slower reaction times on all 3 computerized tasks, the presentation duration did not have an effect on performance in the patients. This study suggests that patients with bipolar disorder are able to recognize faces, but have difficulty processing facial affective cues.

  8. Heart rate variability in bipolar disorder

    DEFF Research Database (Denmark)

    Faurholt-Jepsen, Maria; Kessing, Lars Vedel; Munkholm, Klaus

    2017-01-01

    Background Heart rate variability (HRV) has been suggested reduced in bipolar disorder (BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV differences in BD compared with HC, major depressive disorder or schizophrenia; HRV differences between affective states; HRV...

  9. Bipolarity and Ambivalence in Landscape Architecture

    NARCIS (Netherlands)

    Koh, J.

    2010-01-01

    Our discipline of landscape architecture contains bipolarity, not only in terms of landscape and architecture but also because the idea of landscape is both aesthetic and scientific. Furthermore, within landscape architecture there is a gap between design (as implied by architecture) and planning

  10. Oxide bipolar electronics: materials, devices and circuits

    Science.gov (United States)

    Grundmann, Marius; Klüpfel, Fabian; Karsthof, Robert; Schlupp, Peter; Schein, Friedrich-Leonhard; Splith, Daniel; Yang, Chang; Bitter, Sofie; von Wenckstern, Holger

    2016-06-01

    We present the history of, and the latest progress in, the field of bipolar oxide thin film devices. As such we consider primarily pn-junctions in which at least one of the materials is a metal oxide semiconductor. A wide range of n-type and p-type oxides has been explored for the formation of such bipolar diodes. Since most oxide semiconductors are unipolar, challenges and opportunities exist with regard to the formation of heterojunction diodes and band lineups. Recently, various approaches have led to devices with high rectification, namely p-type ZnCo2O4 and NiO on n-type ZnO and amorphous zinc-tin-oxide. Subsequent bipolar devices and applications such as photodetectors, solar cells, junction field-effect transistors and integrated circuits like inverters and ring oscillators are discussed. The tremendous progress shows that bipolar oxide electronics has evolved from the exploration of various materials and heterostructures to the demonstration of functioning integrated circuits. Therefore a viable, facile and high performance technology is ready for further exploitation and performance optimization.

  11. Unraveling the biology of bipolar disorder using induced pluripotent stem-derived neurons.

    Science.gov (United States)

    Miller, Nathaniel D; Kelsoe, John R

    2017-11-01

    Bipolar disorder has been studied from numerous angles, from pathological studies to large-scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder. We selectively reviewed the literature related to understanding bipolar disorder based on using neurons derived from iPS cells. So far, most work has used the prototypical iPS cells. However, others have been able to transdifferentiate fibroblasts directly to neurons. Others still have utilized olfactory epithelium tissue as a source of neural-like cells that do not need reprogramming. In general, iPS and related cells can be used for studies of disease pathology, drug discovery, or stem cell therapy. Published studies have primarily focused on understanding bipolar disorder pathology, but initial work is also being done to use iPS technology for drug discovery. In terms of disease pathology, some evidence is pointing toward a differentiation defect with more ventral cell types being prominent. Additionally, there is evidence for a calcium signaling defect, a finding that builds on the genome-wide association study results. Continued work with iPS cells will certainly help us understand bipolar disorder and provide a way forward for improved treatments. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Risky alcohol use in young persons with emerging bipolar disorder is associated with increased oxidative stress.

    Science.gov (United States)

    Chitty, Kate M; Lagopoulos, Jim; Hickie, Ian B; Hermens, Daniel F

    2013-09-25

    Alcohol misuse is highly prevalent in bipolar disorder (BD) and has been associated with increased formation of reactive oxygen species in the CNS. Proton magnetic resonance spectroscopy ((1)H-MRS) is an in vivo tissue-based imaging modality that allows the investigation of changes in the brains primary antioxidant, glutathione (GSH), as a result of alcohol use in this population. Thirty-three patients with BD and 17 controls aged 18-30 years were recruited. Participants completed the Alcohol Use Disorders Identification Test (AUDIT) and underwent (1)H-MRS. Levels of GSH in the anterior cingulate cortex (ACC) were determined. ANOVA was conducted to determine differences between high and low risk drinking bipolar participants and controls. ANOVA with all groups revealed a significant difference in GSH between bipolar high and low risk drinkers, with those in the high-risk group displaying reduced GSH levels. A significant negative correlation was found between total AUDIT score and GSH in bipolar (R=-0.478, p=0.005) which remained significant when controlling for age and medication status. Our participant sample consisted of a heterogeneous group of patients, most of whom were medicated at time of testing. Young people with emerging BD who drink at risky levels display reduced levels of ACC-GSH. Increased oxidative stress and its resulting neurotoxic effects may be especially detrimental in an emerging bipolar sample where the illness trajectory is unclear and the brain is still undergoing significant development. © 2013 Elsevier B.V. All rights reserved.

  13. Complete prevention of blood loss with self-sealing haemostatic needles

    Science.gov (United States)

    Shin, Mikyung; Park, Sung-Gurl; Oh, Byung-Chang; Kim, Keumyeon; Jo, Seongyeon; Lee, Moon Sue; Oh, Seok Song; Hong, Seon-Hui; Shin, Eui-Cheol; Kim, Ki-Suk; Kang, Sun-Woong; Lee, Haeshin

    2017-01-01

    Bleeding is largely unavoidable following syringe needle puncture of biological tissues and, while inconvenient, this typically causes little or no harm in healthy individuals. However, there are certain circumstances where syringe injections can have more significant side effects, such as uncontrolled bleeding in those with haemophilia, coagulopathy, or the transmission of infectious diseases through contaminated blood. Herein, we present a haemostatic hypodermic needle able to prevent bleeding following tissue puncture. The surface of the needle is coated with partially crosslinked catechol-functionalized chitosan that undergoes a solid-to-gel phase transition in situ to seal punctured tissues. Testing the capabilities of these haemostatic needles, we report complete prevention of blood loss following intravenous and intramuscular injections in animal models, and 100% survival in haemophiliac mice following syringe puncture of the jugular vein. Such self-sealing haemostatic needles and adhesive coatings may therefore help to prevent complications associated with bleeding in more clinical settings.

  14. Mercury and major essential elements in seals, penguins, and other representative fauna of the Antarctic.

    Science.gov (United States)

    Szefer, P; Czarnowski, W; Pempkowiak, J; Holm, E

    1993-11-01

    Concentrations of total Hg and major essential elements, Ca, Mg, Na, and K, were measured in the muscle, liver, and kidney of three species of seals, crabeater seal (Lobodon carcinophagus), leopard seal (Hydrurga leptonyx), and Weddell seal (Leptonychotes weddelli) collected in the Antarctic. The muscle and liver of three species of penguins, i.e., gentoo penguin (Pygoscelis papua), Adelie penguin (P. adeliae), chinstrap penguin (P. antarctica), and other representative fauna were also analyzed for the elements. Distinct inter-tissue differences in the metal concentration were observed; liver had the greatest concentrations of Hg, kidney showed maximum concentration of Ca and Na, while muscle was characterized by the greatest content of Mg and K. Inter-specimen differentiation of concentrations among the same species was distinctly visualized for Hg but not for the major essential elements. The Hg concentration in the seals analyzed are in keeping with those reported previously by other authors. Such comparison for Ca, Mg, Na, and K was impossible because of the lack of available literature data for their concentrations in marine seals. Numerous significant correlations were observed between concentrations of the several metals analyzed. There was no correlation between Hg, which is a non-essential element and both Zn and Cd which are essential and non-essential elements, respectively in the liver or kidney of seals. However, there were significant correlations between concentration of Zn and the sum of molar concentrations of Hg+Cd in kidney (r = 0.82) and liver (r = 0.76). The results suggest that several control mechanisms operate to maintain physiologically required levels that decreases any effect of heavy metal toxicants such as Hg and Cd.

  15. Seroprevalence of Antibodies against Seal Influenza A(H10N7) Virus in Harbor Seals and Gray Seals from the Netherlands.

    Science.gov (United States)

    Bodewes, Rogier; Rubio García, Ana; Brasseur, Sophie M; Sanchez Conteras, Guillermo J; van de Bildt, Marco W G; Koopmans, Marion P G; Osterhaus, Albert D M E; Kuiken, Thijs

    2015-01-01

    In the spring and summer 2014, an outbreak of seal influenza A(H10N7) virus infection occurred among harbor seals (Phoca vitulina) off the coasts of Sweden and Denmark. This virus subsequently spread to harbor seals off the coasts of Germany and the Netherlands. While thousands of seals were reported dead in Sweden, Denmark and Germany, only a limited number of seals were found dead in the Netherlands. To determine the extent of exposure of seals in the Netherlands to influenza A/H10N7 virus, we measured specific antibody titers in serum samples from live-captured seals and seals admitted for rehabilitation in the Netherlands by use of a hemagglutination inhibition assay and an ELISA. In harbor seals in 2015, antibodies against seal influenza A(H10N7) virus were detected in 41% (32 out of 78) pups, 10% (5 out of 52) weaners, and 58% (7 out of 12) subadults or adults. In gray seals (Halichoerus grypus) in 2015, specific antibodies were not found in the pups (n = 26), but in 26% (5 out of 19) of the older animals. These findings indicate that, despite apparent low mortality, infection with seal influenza A(H10N7) virus was geographically widespread and also occurred in grey seals.

  16. DEVELOPMENT OF A CERAMIC TAMPER INDICATING SEAL: SRNL CONTRIBUTIONS

    Energy Technology Data Exchange (ETDEWEB)

    Krementz, D.; Brinkman, K.; Martinez-Rodriguez, M.; Mendez-Torres, A.; Weeks, G.

    2013-06-03

    Savannah River National Laboratory (SRNL) and Sandia National Laboratories (SNL) are collaborating on development of a Ceramic Seal, also sometimes designated the Intrinsically Tamper Indicating Ceramic Seal (ITICS), which is a tamper indicating seal for international safeguards applications. The Ceramic Seal is designed to be a replacement for metal loop seals that are currently used by the IAEA and other safeguards organizations. The Ceramic Seal has numerous features that enhance the security of the seal, including a frangible ceramic body, protective and tamper indicating coatings, an intrinsic unique identifier using Laser Surface Authentication, electronics incorporated into the seal that provide cryptographic seal authentication, and user-friendly seal wire capture. A second generation prototype of the seal is currently under development whose seal body is of Low Temperature Co-fired Ceramic (LTCC) construction. SRNL has developed the mechanical design of the seal in an iterative process incorporating comments from the SNL vulnerability review team. SRNL is developing fluorescent tamper indicating coatings, with recent development focusing on optimizing the durability of the coatings and working with a vendor to develop a method to apply coatings on a 3-D surface. SRNL performed a study on the effects of radiation on the electronics of the seal and possible radiation shielding techniques to minimize the effects. SRNL is also investigating implementation of Laser Surface Authentication (LSA) as a means of unique identification of each seal and the effects of the surface coatings on the LSA signature.

  17. Temporal variation in isotopic composition and diet of Weddell seals in the western Ross Sea

    Science.gov (United States)

    Goetz, Kimberly T.; Burns, Jennifer M.; Hückstӓdt, Luis A.; Shero, Michelle R.; Costa, Daniel P.

    2017-06-01

    Weddell seals (Leptonychotes weddellii) are important predators in the Antarctic marine ecosystem, yet little is known about their diet. Previous studies have used scat and stomach content analyses to examine Weddell seal diet, however, these methods are biased towards prey with indigestible hard parts. To provide a more complete picture of their diet, we analyzed the stable isotope composition (δ13C and δ15N values) of red blood cells (RBC, n=96, representing a time scale of weeks to months) and vibrissae (n=45, representing months to a year) collected over a three year period (2010-2012). Our objectives were to (1) examine isotopic variation in relation to Weddell seal mass, sex, season, location, percent lipid, and age, and (2) quantify the contribution of prey items to overall diet. Body mass was a significant predictor of δ13C and δ15N values for both tissues, though the strength and direction of the relationship varied by year. The prey group consisting of Pleurogramma antarcticum and Trematomus newnesi was found to be an important dietary component, but its proportional contribution to Weddell seal diet varied with the timeframe represented by each tissue type [median RBC (range): 59.2% (40.2-8 1.1%); median mean vibrissae (range): 69.3% (43.9-89.6%)]. Results from mixing models ran for each seal indicate individual variation in diet. Overall, this study presents novel information on the isotopic variation and diet of Weddell seals over two time scales and provides insight into the feeding ecology of an important Antarctic predator.

  18. Gas-lubricated seal for sealing between a piston and a cylinder wall

    Science.gov (United States)

    Hoult, D.P.

    1985-09-10

    A piston-cylinder seal uses gas for a lubricant and has a runner supported on a gapless structure and placed in the space between the piston and the cylinder wall. The runner is deformed elastically under the influence of the operating pressures to follow and compensate for variations in the piston-cylinder fit and maintain a seal. 4 figs.

  19. Development of a Whole Container Seal

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, Michael J [ORNL; Pickett, Chris A [ORNL; Stinson, Brad J [ORNL; Rowe, Nathan C [ORNL

    2014-01-01

    This paper outlines a technique for utilizing electrically conductive textiles as a whole container seal. This method has the potential to provide more robustness for ensuring that the container has not been breached versus conventional sealing methods that only provide tamper indication at the area used for normal access. The conductive textile is used as a distributed sensor for detecting and localizing container tamper or breach. For sealing purposes, the conductive fabric represents a bounded, near-infinite grid of resistors. The well-known infinite resistance grid problem was used to model and confirm the expected accuracy and validity of this approach. An experimental setup was built that uses a multiplexed Wheatstone bridge measurement to determine the resistances of a coarse electrode grid across the conductive fabric. Non-uniform resistance values of the grid infer the presence of damage or tears in the fabric. Results suggest accuracy proportional to the electrode spacing in determining the presence and location of disturbances in conductive fabric samples. Current work is focused on constructing experimental prototypes for field and environmental testing to gauge the performance of these whole container seals in real world conditions. We are also developing software and hardware to interface with the whole container seals. The latest prototypes are expected to provide more accuracy in detecting and localizing events, although detection of a penetration should be adequate for most sealing applications. We are also developing smart sensing nodes that integrate digital hardware and additional sensors (e.g., motion, humidity) into the electrode nodes within the whole container seal.

  20. Materials for water pump mechanical seals

    International Nuclear Information System (INIS)

    Brousse, P.

    1992-01-01

    In view of the continually increasing power ratings of conventional and nuclear power plants and the related reliability and safety problems, plant builders have had to develop seal systems compatible with current water pump performances. In 1970, EDF/R and DD was already concerned by this problem. It soon became obvious that the nature of the materials used for the friction surfaces was decisive for seal durability. Exceptional loads (transients, high vibration levels, etc...) hasten aging. To begin with, friction surfaces consisted of a hard material (tungsten carbide) mated with a soft material (carbon). Resistance was unpredictable and not compatible with industrial requirements. Tests performed on the EDF/R and DD test benches evidenced the same types of degradation. The mechanical seal manufacturers then began to use ceramic materials (silicon carbide), which raised high expectations. Unfortunately, these were recent materials and their manufacturing process was not thoroughly understood. Hopes were soon dashed in many applications, including that of mechanical seals. Fluctuating results were obtained over the next few years. The raw material suppliers made progress, especially with regard to reducing fragility. On a parallel, the mechanical seal manufacturers initiated comparative tests on the friction resistance of materials. It has also been established that ceramics have to be stringently supervised at all levels: part design, inspection, assembly, use. EDF has much insisted that mechanical seal suppliers guarantee the constant quality of their products. EDF/R and DD has systematically tested new sensitive devices, under normal and exceptional conditions, prior to their installation at the plants. At the present time, the silicon carbides proposed by the mechanical seal suppliers are entirely satisfactory. The carbon mating surface was far less problematic. The required reliability was obtained by replacing resin binder carbons by the more resistant

  1. Three-dimension finite-element analyses of multiple electrodes bipolar RF global endometrial ablation

    Science.gov (United States)

    Hu, Tao; Panhao, Tang; Xiao, Jiahua

    2015-03-01

    Radio-frequency ablation (RFA) is a minimally invasive surgical procedure to thermally ablate the targeted diseased tissue. There have been many finite-element method (FEM) studies of cardiac and hepatic RFA, but hardly find any FEM study on endometrial ablation for abnormal uterine bleeding. In this paper, a FEM model was generated to analyze the temperature distribution of bipolar RF global endometrial ablation with three pairs of bipolar electrodes placed at the perimeter of the uterine cavity. COMSOL was utilized to calculate the RF electric fields and temperature fields by numerically solving the bioheat equation in the triangle uterine cavity range. The 55°C isothermal surfaces show the shape of the ablation dimensions (depth and width), which reasonably matched the experimental results.

  2. The relationship between borderline personality disorder and bipolar disorder

    Science.gov (United States)

    Zimmerman, Mark; Morgan, Theresa A.

    2013-01-01

    It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We reviewed the most studied question on the relationship between BPD and bipolar disorder: their diagnostic concordance. Across studies, approximately 10% of patients with BPD had bipolar I disorder and another 10% had bipolar II disorder. Likewise, approximately 20% of bipolar II patients were diagnosed with BPD, though only 10% of bipolar I patients were diagnosed with BPD. While the comorbidity rates are substantial, each disorder is nontheless diagnosed in the absence of the other in the vast majority of cases (80% to 90%). In studies examining personality disorders broadly, other personality disorders were more commonly diagnosed in bipolar patients than was BPD. Likewise, the converse is also true: other axis I disorders such as major depression, substance abuse, and post-traumatic stress disorder are also more commonly diagnosed in patients with BPD than is bipolar disorder. These findings challenge the notion that BPD is part of the bipolar spectrum. PMID:24174890

  3. Sleep study in Disruptive Mood Dysregulation Disorder and Bipolar children.

    Science.gov (United States)

    Estrada-Prat, Xavier; Álvarez-Guerrico, Ion; Bleda-Hernández, María J; Camprodon-Rosanas, Ester; Batlle-Vila, Santiago; Pujals-Altes, Elena; Nascimento-Osorio, María T; Martín-López, Luís M; Álvarez-Martínez, Enric; Pérez-Solá, Víctor; Romero-Cela, Soledad

    2017-01-01

    Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD). All participants underwent a psychiatric semi-structured interview to obtain the diagnosis, comorbidities and primary sleep disorders. DMDD’s sample was performed following DSM5 criteria. Perform polysomnography in a sample of bipolar, DMDD and ADHD children and compare their profiles to provide more evidence about the differences or similarities between bipolar disorder and DMDD. Bipolar group had the highest REM density values while ADHD had the lowest. REM density was not statiscally different between bipolar phenotypes. REM density was associated with antidepressant treatment, episodes of REM and their interaction. REM latency was associated with antipsychotic treatment and school performance. Bipolar patients had higher scores on the depression scale than DMDD and ADHD groups. No significant differences between the two compared affective disorders were found. However there were differences in REM density between bipolar and ADHD groups. REM sleep study could provide a new theoretical framework to better understand the pathogenesis of pediatric bipolar disorder.

  4. Solid oxide fuel cell having a glass composite seal

    Science.gov (United States)

    De Rose, Anthony J.; Mukerjee, Subhasish; Haltiner, Jr., Karl Jacob

    2013-04-16

    A solid oxide fuel cell stack having a plurality of cassettes and a glass composite seal disposed between the sealing surfaces of adjacent cassettes, thereby joining the cassettes and providing a hermetic seal therebetween. The glass composite seal includes an alkaline earth aluminosilicate (AEAS) glass disposed about a viscous glass such that the AEAS glass retains the viscous glass in a predetermined position between the first and second sealing surfaces. The AEAS glass provides geometric stability to the glass composite seal to maintain the proper distance between the adjacent cassettes while the viscous glass provides for a compliant and self-healing seal. The glass composite seal may include fibers, powders, and/or beads of zirconium oxide, aluminum oxide, yttria-stabilized zirconia (YSZ), or mixtures thereof, to enhance the desirable properties of the glass composite seal.

  5. Method and system to facilitate sealing in gas turbines

    Science.gov (United States)

    Morgan, Victor John; Foster, Gregory Thomas; Sarawate, Neelesh Nandkumar

    2017-09-12

    A method and system for sealing between components within a gas turbine is provided. A first recess defined in a first component receives a seal member. A second recess defined in a second component adjacent the first component also receives the seal member. The first and second recesses are located proximate a hot gas path defined through the gas turbine, and define circumferential paths about the turbine axis. The seal member includes a sealing face that extends in a direction substantially parallel to the turbine axis. The seal member also includes a plurality of seal layers, wherein at least one of the seal layers includes at least one stress relief region for facilitating flexing of the first seal member.

  6. Advanced Seal Development for Large Industrial Gas Turbines

    Science.gov (United States)

    Chupp, Raymond E.

    2006-01-01

    Efforts are in progress to develop advanced sealing for large utility industrial gas turbine engines (combustion turbines). Such seals have been under developed for some time for aero gas turbines. It is desired to transition this technology to combustion turbines. Brush seals, film riding face and circumferential seals, and other dynamic and static sealing approaches are being incorporated into gas turbines for aero applications by several engine manufacturers. These seals replace labyrinth or other seals with significantly reduced leakage rates. For utility industrial gas turbines, leakage reduction with advanced sealing can be even greater with the enormous size of the components. Challenges to transitioning technology include: extremely long operating times between overhauls; infrequent but large radial and axial excursions; difficulty in coating larger components; and maintenance, installation, and durability requirements. Advanced sealing is part of the Advanced Turbine Systems (ATS) engine development being done under a cooperative agreement between Westinghouse and the US Department of Energy, Office of Fossil Energy. Seal development focuses on various types of seals in the 501ATS engine both at dynamic and static locations. Each development includes rig testing of candidate designs and subsequent engine validation testing of prototype seals. This presentation gives an update of the ongoing ATS sealing efforts with special emphasis on brush seals.

  7. Transfer of PBDEs and chlorinated POPs from mother to pup during lactation in harp seals Phoca groenlandica.

    Science.gov (United States)

    Frouin, Héloïse; Lebeuf, Michel; Hammill, Mike; Fournier, Michel

    2012-02-15

    Seven mother-pup pairs of harp seal (Phoca groenlandica) were sampled during the lactation season near Magdalen Islands, QC, Canada. The blubber and serum of pups and mothers as well as the milk of mothers were analyzed for polybrominated diphenyl ethers and several chlorinated persistent organic pollutants (POPs) to evaluate their transfer prior to weaning. Principal component analysis demonstrated significant variations in contaminant distribution patterns between seal tissues of mothers and pups. The selectivity in the transfer of POPs between mothers and pups appeared mainly driven by their log K(ow) (octanol/water partition coefficient). The most selective transfer step for the POPs examined occurred between the blubber and the serum of the mother. A novel approach to examine temporal changes of POP concentrations in tissues of seals which take into account the contamination of mothers was developed. A general decrease of POP concentrations in pup tissues throughout lactation may suggest a growth dilution. A concomitant rise of POP concentrations was observed in maternal blubber and serum and in milk as lactation progresses. The intensive offloading of contaminants via lactation constitutes a major but selective excretory route for reproductive female seals and also a significant route of exposure for suckling pup seals. Copyright © 2011 Elsevier B.V. All rights reserved.

  8. Design Vulnerability Assessments for Safeguards Sealing Systems

    International Nuclear Information System (INIS)

    Brockman, Linda; Johnston, Roger; Kravtchenko, Victor; Undem, Halvor A.; Wishard, Bernard

    2010-01-01

    The International Atomic Energy Agency (the 'Agency') engages in a rigorous equipment authorization process prior to deploying Safeguards instrumentation, including Safeguards sealing systems, for world-wide use. A positive result from a vulnerability assessment is one of the many requirements that must be met prior to instrumentation deployment. Given the long time period in the Safeguards instrumentation development cycle, the substantial Member State investments made, and the significant Agency staff time required, a negative result for the vulnerability assessment can result in the loss of time, considerable additional expense, or even the failure to deploy an instrument or sealing system at all. First suggested in 1998 by the General Physics Institute in Moscow, an approach that incorporates a design vulnerability assessment minimizes the risk of deployment failure by teaming a public sector vulnerability assessment team with the instrument or sealing system design team in order to identify, at the earliest possible design stage, inherent vulnerabilities. Involving the vulnerability assessors early and often in the design and development process avoids many of the problems inherent in evaluating security vulnerabilities only after the design is finalized. The disadvantages include increased costs and time to deployment. An improved pressure-sensitive adhesive label seal, called the 'VOID-3 seal' was developed for the Agency using this design vulnerability assessment process.

  9. Modeling the rubbing contact in honeycomb seals

    Science.gov (United States)

    Fischer, Tim; Welzenbach, Sarah; Meier, Felix; Werner, Ewald; kyzy, Sonun Ulan; Munz, Oliver

    2018-03-01

    Metallic honeycomb labyrinth seals are commonly used as sealing systems in gas turbine engines. Because of their capability to withstand high thermo-mechanical loads and oxidation, polycrystalline nickel-based superalloys, such as Hastelloy X and Haynes 214, are used as sealing material. In addition, these materials must exhibit a tolerance against rubbing between the rotating part and the stationary seal component. The tolerance of the sealing material against rubbing preserves the integrity of the rotating part. In this article, the rubbing behavior at the rotor-stator interface is considered numerically. A simulation model is incorporated into the commercial finite element code ABAQUS/explicit and is utilized to simulate a simplified rubbing process. A user-defined interaction routine between the contact surfaces accounts for the thermal and mechanical interfacial behavior. Furthermore, an elasto-plastic constitutive material law captures the extreme temperature conditions and the damage behavior of the alloys. To validate the model, representative quantities of the rubbing process are determined and compared with experimental data from the literature. The simulation results correctly reproduce the observations made on a test rig with a reference stainless steel material (AISI 304). A parametric study using the nickel-based superalloys reveals a clear dependency of the rubbing behavior on the sliding and incursion velocity. Compared to each other, the two superalloys studied exhibit a different rubbing behavior.

  10. Modeling the rubbing contact in honeycomb seals

    Science.gov (United States)

    Fischer, Tim; Welzenbach, Sarah; Meier, Felix; Werner, Ewald; kyzy, Sonun Ulan; Munz, Oliver

    2017-12-01

    Metallic honeycomb labyrinth seals are commonly used as sealing systems in gas turbine engines. Because of their capability to withstand high thermo-mechanical loads and oxidation, polycrystalline nickel-based superalloys, such as Hastelloy X and Haynes 214, are used as sealing material. In addition, these materials must exhibit a tolerance against rubbing between the rotating part and the stationary seal component. The tolerance of the sealing material against rubbing preserves the integrity of the rotating part. In this article, the rubbing behavior at the rotor-stator interface is considered numerically. A simulation model is incorporated into the commercial finite element code ABAQUS/explicit and is utilized to simulate a simplified rubbing process. A user-defined interaction routine between the contact surfaces accounts for the thermal and mechanical interfacial behavior. Furthermore, an elasto-plastic constitutive material law captures the extreme temperature conditions and the damage behavior of the alloys. To validate the model, representative quantities of the rubbing process are determined and compared with experimental data from the literature. The simulation results correctly reproduce the observations made on a test rig with a reference stainless steel material (AISI 304). A parametric study using the nickel-based superalloys reveals a clear dependency of the rubbing behavior on the sliding and incursion velocity. Compared to each other, the two superalloys studied exhibit a different rubbing behavior.

  11. Tribological Studies of Dynamic Thermal Seal Materials

    Science.gov (United States)

    DeMange, Jeffrey J.; Taylor, Shawn C.

    2016-01-01

    Thermal seals are required on high-speed vehicles in many dynamic applications such as variable inlets in propulsion systems and control surfaces. These seals, often referred to as dynamic thermal seals, must not only mitigate inboard heat transfer, but must also exhibit sufficient durability when scrubbed against mating surfaces. For high-temperature high-speed vehicle applications, the mating surfaces are often made from thermal protection system (TPS) materials, which are typically rougher and more abrasive than TPS materials used at lower temperatures. The high-temperature TPS materials used can include non-ablative (e.g., lightweight porous oxides, ceramic matrix composites) andor ablative systems (e.g., phenolic systems). Due to the increased need for durable high-temperature dynamic seals, researchers working with the NASA Glenn Research Center embarked on an effort to (a) characterize the tribological performance of state-of-the-art thermal seal materials against a variety of TPS materials and (b) develop approaches for improved wear resistance. Tests were conducted using a recently upgraded high-temperature tribometer to assess wear resistance for a variety of tribopairs under multiple conditions. This data will begin to frame the challenges of using these materials and eventually permit an improved ability to design and implement these critical TPS components.

  12. No Child's Fate Is Sealed

    Science.gov (United States)

    Hawkes, T. Elijah

    2012-01-01

    A lot of children are suffering--from bullet wounds, car crashes, gashes in legs, and great tears in the social fabric. There are wounds to heal, hopes to foster, and scar tissue to form. Public school teachers and leaders, wherever we are, this is our work. And we can do a good job of it, if the school community is strong, and if we always work…

  13. Systematic review of the prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies.

    Science.gov (United States)

    Dell'Aglio, José Caetano; Basso, Lissia Ana; Argimon, Irani Iracema de Lima; Arteche, Adriane

    2013-01-01

    This paper describes the findings of a systematic literature review aimed at providing an overview of the lifetime prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies. Databases MEDLINE, ProQuest, Psychnet, and Web of Science were browsed for papers published in English between 1999 and May 2012 using the following search string: bipolar disorders OR bipolar spectrum disorders AND prevalence OR cross-sectional OR epidemiology AND population-based OR non-clinical OR community based. The search yielded a total of 434 papers, but only those published in peer-reviewed journals and with samples aged ≥ 18 years were included, resulting in a final sample of 18 papers. Results revealed rather heterogeneous findings concerning the prevalence of bipolar disorders and bipolar spectrum disorders. Lifetime prevalence of bipolar disorder ranged from 0.1 to 7.5%, whereas lifetime prevalence of bipolar spectrum disorders ranged from 2.4 to 15.1%. Differences in the rates of bipolar disorder and bipolar spectrum disorders may be related to the consideration of subthreshold criteria upon diagnosis. Differences in the prevalence of different subtypes of the disorder are discussed in light of diagnostic criteria and instruments applied.

  14. Systematic review of the prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies

    Directory of Open Access Journals (Sweden)

    José Caetano Dell'Aglio Jr.

    2013-01-01

    Full Text Available This paper describes the findings of a systematic literature review aimed at providing an overview of the lifetime prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies. Databases MEDLINE, ProQuest, Psychnet, and Web of Science were browsed for papers published in English between 1999 and May 2012 using the following search string: bipolar disorders OR bipolar spectrum disorders AND prevalence OR cross-sectional OR epidemiology AND population-based OR non-clinical OR community based. The search yielded a total of 434 papers, but only those published in peer-reviewed journals and with samples aged ≥ 18 years were included, resulting in a final sample of 18 papers. Results revealed rather heterogeneous findings concerning the prevalence of bipolar disorders and bipolar spectrum disorders. Lifetime prevalence of bipolar disorder ranged from 0.1 to 7.5%, whereas lifetime prevalence of bipolar spectrum disorders ranged from 2.4 to 15.1%. Differences in the rates of bipolar disorder and bipolar spectrum disorders may be related to the consideration of subthreshold criteria upon diagnosis. Differences in the prevalence of different subtypes of the disorder are discussed in light of diagnostic criteria and instruments applied.

  15. Abordagens psicoterápicas no transtorno bipolar Psychoterapeutic approach in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Paulo Knapp

    2005-01-01

    Full Text Available Embora o tratamento farmacológico seja essencial para o tratamento do transtorno bipolar, apenas 40% de todos os pacientes que aderem às medicações permanecem assintomáticos durante o período de seguimento, o que tem levado ao desenvolvimento de intervenções psicoterápicas associadas. O objetivo deste artigo é examinar as evidências atuais da eficácia de intervenções psicoterápicas no tratamento do transtorno bipolar. Foi realizada uma pesquisa bibliográfica por meio do MedLine, PsychoINFO, Lilacs e Cochrane Data Bank, até o ano de 2004, em que foram procurados artigos originais e revisões sobre as abordagens psicoterápicas utilizadas no tratamento do transtorno bipolar. Há várias abordagens que podem se mostrar úteis no tratamento do transtorno bipolar. A psicoeducação e a terapia cognitivo-comportamental apresentam as evidências mais consistentes e são as técnicas mais amplamente estudadas. As intervenções envolvendo familiares e a terapia interpessoal e de ritmo social se mostram tratamentos eficazes em determinadas situações. Há alguns estudos empregando a terapia psicodinâmica no transtorno bipolar, mas são estudos com limitações metodológicas. Apesar de haver evidências demonstrando a eficácia de determinadas abordagens psicoterápicas no transtorno bipolar, ainda é necessária a realização de estudos posteriores que comprovem tais dados e que desenvolvam tratamentos baseados em modelos etiológicos e que identifiquem tratamentos específicos para as diferentes fases e tipos de transtorno bipolar.Although pharmacological treatment is essential for treating bipolar disorder, less than half of all medication compliant patients are non-symptomatic during follow-up, which has led to developments of adjunctive psychosocial interventions. This paper examines the current evidence for effectiveness of psychotherapeutic interventions in the treatment of bipolar disorder. Searches were undertaken through Med

  16. 137Cs and 210Po in Pacific walrus and bearded seal from St. Lawrence Island, Alaska.

    Science.gov (United States)

    Hamilton, Terry; Seagars, Dana; Jokela, Terry; Layton, David

    2008-06-01

    The activity concentration of Cesium-137 ((137)Cs) and naturally-occurring Polonium-210 ((210)Po) were measured in the muscle tissue, kidney and liver of Pacific walrus (Odobenus rosmarus divergens) and bearded seal (Erignathus barbatus) collected by native hunters from the Bering Sea during May 1996. The mean (137)Cs concentrations in muscle, liver and kidney of Pacific walrus were 0.07, 0.09 and 0.07 Bq kg(-1) (n=5, wet weight), respectively, and 0.17, 0.10, and 0.17 Bq kg(-1) (n=2, wet weight), respectively, in bearded seal. In general, (137)Cs tissue concentrations are significantly lower than those previously reported for mammals from other regions. By comparison, (210)Po activity concentrations are more variable and appear to be higher level compared with mammal data from other regions. The mean (210)Po concentration in the muscle tissue, liver and kidney of Pacific walrus (n=5, wet weight) were 28.7, 189, and 174 Bq kg(-1), respectively. This compares with (210)Po concentration values (n=2, wet weight) of 27, 207 and 68 Bq kg(-1) measured in the muscle tissue, liver and kidney, of bearded seal, respectively. Estimated concentration factors--as defined by the radionuclide concentration ratio between the target tissue to that in sea water--were two to three orders of magnitude higher for (210)Po that those of (137)Cs. We conclude from radiological dose estimates that ingestion of (137)Cs in foods derived from walrus and seal will pose no threat to human health. This work has important implications for assessment of risks of Alaskan coastal communities concerned about the dumping of nuclear waste in the Russia Arctic.

  17. 137Cs and 210Po in Pacific Walrus and Bearded Seal from St. Lawrence Island, Alaska

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, T F; Seagars, D J; Jokela, T; Layton, D

    2005-02-02

    The activity concentration of Cesium-137 ({sup 137}Cs) and naturally-occurring Polonium-210 ({sup 210}Po) were measured in the muscle tissue, kidney and liver of Pacific walrus (Odobenus rosmarus divergens) and bearded seal (Erignathus barbatus) collected by native hunters from the Bering Sea. The mean {sup 137}Cs concentrations in muscle, liver and kidney of Pacific walrus were 0.07, 0.09 and 0.07 Bq kg{sup -1} (N= 5, wet weight), respectively, and 0.17, 0.10, and 0.17 Bq kg{sup -1} (N=2, wet weight), respectively, in bearded seal. In general, {sup 137}Cs tissue concentrations are significantly lower than those previously reported for mammals from other regions. By comparison, {sup 210}Po activity concentrations appear to be higher than those reported elsewhere but a larger variation. The mean {sup 210}Po concentration in the muscle tissue, liver and kidney of Pacific walrus (N=5, wet weight) were 28.7, 189, and 174 Bq kg{sup -1}, respectively. This compares with {sup 210}Po concentration values (N=2, wet weight) of 27, 207, and 68 Bq kg{sup -1} measured in the muscle tissue, liver and kidney, of bearded seal, respectively. Estimated bioaccumulation factors--as defined by the radionuclide concentration ratio between the target tissue to that in sea water--were two to three orders of magnitude higher for {sup 210}Po that those of {sup 137}Cs. We conclude from radiological dose estimates that ingestion of {sup 137}Cs in foods derived from walrus and seal will pose no threat to human health. This work has important implications for assessing health risks to Alaskan coastal communities concerned about the dumping of nuclear waste in the Russia Arctic.

  18. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye.

    Directory of Open Access Journals (Sweden)

    Aditi Bauskar

    Full Text Available Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating stress that mimics dry eye. Using this mouse model, we show here that CLU prevents and ameliorates ocular surface barrier disruption by a remarkable sealing mechanism dependent on attainment of a critical all-or-none concentration. When the CLU level drops below the critical all-or-none threshold, the barrier becomes vulnerable to desiccating stress. CLU binds selectively to the ocular surface subjected to desiccating stress in vivo, and in vitro to the galectin LGALS3, a key barrier component. Positioned in this way, CLU not only physically seals the ocular surface barrier, but it also protects the barrier cells and prevents further damage to barrier structure. These findings define a fundamentally new mechanism for ocular surface protection and suggest CLU as a biotherapeutic for dry eye.

  19. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye.

    Science.gov (United States)

    Bauskar, Aditi; Mack, Wendy J; Mauris, Jerome; Argüeso, Pablo; Heur, Martin; Nagel, Barbara A; Kolar, Grant R; Gleave, Martin E; Nakamura, Takahiro; Kinoshita, Shigeru; Moradian-Oldak, Janet; Panjwani, Noorjahan; Pflugfelder, Stephen C; Wilson, Mark R; Fini, M Elizabeth; Jeong, Shinwu

    2015-01-01

    Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating stress that mimics dry eye. Using this mouse model, we show here that CLU prevents and ameliorates ocular surface barrier disruption by a remarkable sealing mechanism dependent on attainment of a critical all-or-none concentration. When the CLU level drops below the critical all-or-none threshold, the barrier becomes vulnerable to desiccating stress. CLU binds selectively to the ocular surface subjected to desiccating stress in vivo, and in vitro to the galectin LGALS3, a key barrier component. Positioned in this way, CLU not only physically seals the ocular surface barrier, but it also protects the barrier cells and prevents further damage to barrier structure. These findings define a fundamentally new mechanism for ocular surface protection and suggest CLU as a biotherapeutic for dry eye.

  20. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye

    Science.gov (United States)

    Bauskar, Aditi; Mack, Wendy J.; Mauris, Jerome; Argüeso, Pablo; Heur, Martin; Nagel, Barbara A.; Kolar, Grant R.; Gleave, Martin E.; Nakamura, Takahiro; Kinoshita, Shigeru; Moradian-Oldak, Janet; Panjwani, Noorjahan; Pflugfelder, Stephen C.; Wilson, Mark R.; Fini, M. Elizabeth; Jeong, Shinwu

    2015-01-01

    Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating stress that mimics dry eye. Using this mouse model, we show here that CLU prevents and ameliorates ocular surface barrier disruption by a remarkable sealing mechanism dependent on attainment of a critical all-or-none concentration. When the CLU level drops below the critical all-or-none threshold, the barrier becomes vulnerable to desiccating stress. CLU binds selectively to the ocular surface subjected to desiccating stress in vivo, and in vitro to the galectin LGALS3, a key barrier component. Positioned in this way, CLU not only physically seals the ocular surface barrier, but it also protects the barrier cells and prevents further damage to barrier structure. These findings define a fundamentally new mechanism for ocular surface protection and suggest CLU as a biotherapeutic for dry eye. PMID:26402857